locus-tag class description AW22_1011 ENOG4105T6C Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps AW22_1014 ENOG4105BZ1 (ABC) transporter AW22_1015 ENOG4105BZ1 (ABC) transporter AW22_1018 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AW22_102 ENOG4105DR4 Methyltransferase AW22_1023 ENOG41067MG lrgb family AW22_1025 ENOG4107RSM transcriptional regulator AW22_1027 ENOG4105CJ1 ABC, transporter AW22_1029 ENOG4105CH2 amidohydrolase AW22_1031 ENOG4107QIV Cytochrome c biogenesis protein AW22_1034 ENOG4105EKQ RNA-directed DNA polymerase AW22_1042 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) AW22_1047 ENOG4108903 Formimidoylglutamase AW22_1048 ENOG4108VJ1 Transcriptional regulator (CarD family AW22_1049 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AW22_105 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AW22_1050 ENOG4105CBC glutamate synthase AW22_1051 ENOG4105CK7 Sodium proline symporter AW22_1052 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase AW22_1053 ENOG4105FBA Phospholipase Carboxylesterase AW22_1054 ENOG4105BZU Histidine kinase AW22_1056 ENOG4107AYK membrAne AW22_1066 ENOG4108IMY Transcriptional regulator AW22_1068 ENOG4105CEY Amp-dependent synthetase and ligase AW22_1069 ENOG4107ZYJ bioY protein AW22_1070 ENOG4107F3J Amp-dependent synthetase and ligase AW22_1074 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AW22_1076 ENOG4105E5W Transporter AW22_1082 ENOG4108I0Z Aconitate hydratase AW22_1083 ENOG4108JJA ABC, transporter AW22_1085 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AW22_1086 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AW22_1092 ENOG4105W8X HesB YadR YfhF-family protein AW22_1094 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase AW22_1095 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) AW22_1096 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW22_1097 ENOG4105C0H protease AW22_1098 ENOG4105K4P CoA-binding domain protein AW22_1099 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AW22_1101 ENOG4105D9R oxidoreductase AW22_1103 ENOG4105CIG ABC transporter AW22_1107 ENOG4105EMN RNA polymerase sigma factor AW22_1110 ENOG4108KGH TRANSCRIPTIONal AW22_1111 ENOG4107QJT sodium dicarboxylate symporter AW22_1125 ENOG4105E1K spore germination protein AW22_1127 ENOG4108JB9 formate dehydrogenase AW22_1129 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) AW22_113 ENOG4105S6R Iron-hydroxamate transporter permease subunit AW22_1130 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AW22_1132 ENOG4105TMB Formate nitrite transporter AW22_1133 ENOG4105D06 uba thif-type nad fad binding protein AW22_1134 ENOG4105CVM Molybdenum cofactor synthesis domain protein AW22_1135 ENOG4108ZAF Molybdopterin AW22_1137 ENOG4105D1F ATP-binding protein AW22_114 ENOG4105J76 Periplasmic binding protein AW22_1140 ENOG410696E Membrane AW22_1141 ENOG4105FR1 rard protein AW22_1143 ENOG4105EWU Squalene--hopene cyclase AW22_1145 ENOG4105CHR reductase AW22_1146 ENOG4105C26 Dehydrogenase AW22_1148 ENOG4108IA2 Sodium pantothenate symporter AW22_1151 ENOG4106IQC argininosuccinate lyase AW22_1153 ENOG410904N short-chain dehydrogenase reductase AW22_116 ENOG4105CEY Amp-dependent synthetase and ligase AW22_1162 ENOG4105VEQ Cold shock protein AW22_1165 ENOG4108R1P AW22_1167 ENOG41073R8 VanW family AW22_1168 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AW22_117 ENOG4107Z3H Transcriptional regulator, TetR family AW22_1170 ENOG4105KT7 mgtC SapB transporter AW22_1172 ENOG4105E39 Enoyl-CoA hydratase AW22_1173 ENOG4105K64 Glycosyl transferase, family 2 AW22_1175 ENOG4108UT6 Transferase hexapeptide repeat containing protein AW22_1179 ENOG4105CQB FAD linked oxidase domain protein AW22_118 ENOG41060WC Enoyl-CoA hydratase AW22_1180 ENOG4105C09 Bile acid AW22_1188 ENOG4105CIS alcohol dehydrogenase AW22_1189 ENOG41082BM Transcriptional regulator, arsr family AW22_119 ENOG4105BZJ Electron transfer flavoprotein AW22_1194 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AW22_120 ENOG4105C10 Electron transfer flavoprotein AW22_1200 ENOG4108A04 Beta-lactamase AW22_1201 ENOG4105DPN Oligoendopeptidase f AW22_1202 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AW22_1203 ENOG4105E5K Alpha-amylase AW22_1206 ENOG4105C98 muts2 protein AW22_121 ENOG4105K63 Thioredoxin AW22_1210 ENOG4107V2S Transcriptional regulator AW22_1214 ENOG4107ZY0 Phenazine biosynthesis-like protein AW22_1215 ENOG4105NX3 Membrane AW22_1216 ENOG4105DQ5 transport system permease protein AW22_1217 ENOG4105EHG Permease protein AW22_1218 ENOG4108MES Periplasmic binding protein AW22_1221 ENOG4107R3E Citrate transporter AW22_1223 ENOG4108TN2 lmbE family AW22_1229 ENOG4105CIS alcohol dehydrogenase AW22_1237 ENOG4105H3G oxidoreductase AW22_124 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit AW22_1244 ENOG4107YXZ hydrolase, family 25 AW22_1246 ENOG4105D7V transposase AW22_1247 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) AW22_1259 ENOG4108ZJ4 polysaccharide deacetylase AW22_126 ENOG4105E33 succinate dehydrogenase AW22_1261 ENOG4105KVH Transcriptional regulator AW22_1262 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AW22_1266 ENOG4105JAB phenazine biosynthesis protein, phzf family AW22_1274 ENOG4105D9R oxidoreductase AW22_1275 ENOG4108TZY GntR Family Transcriptional Regulator AW22_128 ENOG4108VXD carboxy-peptidase AW22_1281 ENOG4105C44 Serine transporter AW22_1287 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AW22_129 ENOG4105E14 MotA TolQ exbB proton channel AW22_1290 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AW22_1291 ENOG4105C6Z Gluconate AW22_1292 ENOG4105CMG Carbohydrate kinase AW22_1293 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AW22_1294 ENOG4105XDF Protein of unknown function (DUF1272) AW22_1295 ENOG4105DDN Pentapeptide repeat-containing protein AW22_1298 ENOG4105C37 (CBS) domain AW22_13 ENOG4105VZ8 Transcriptional regulator AW22_130 ENOG4105ER2 Ompa motb domain protein AW22_1304 ENOG4105EV4 Multidrug resistance protein mdtH AW22_1306 ENOG4105DMQ Methyltransferase AW22_131 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family AW22_1312 ENOG4105C31 Tryptophanyl-tRNA synthetase AW22_1314 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AW22_1317 ENOG4108UW5 maltose o-acetyltransferase AW22_1318 ENOG4105DKQ ROK family AW22_1319 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase AW22_132 ENOG4108IUX (ABC) transporter AW22_1327 ENOG4105D7V transposase AW22_133 ENOG4105RHA ABC transporter, permease AW22_1336 ENOG4105CJ1 ABC, transporter AW22_1338 ENOG4108PSK reductase AW22_134 ENOG4108Z40 Transcriptional regulator AW22_1342 ENOG4105CA9 Pyruvate kinase AW22_1344 ENOG4108RCM Nitroreductase AW22_1345 ENOG4105KVH Transcriptional regulator AW22_1349 ENOG4105WH1 Two component transcriptional regulator luxr family AW22_135 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AW22_1351 ENOG4108Z66 YbaK ebsC protein AW22_1352 ENOG4108K8S endonuclease I AW22_1357 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AW22_1364 ENOG4105DYS nad(p)h dehydrogenase (quinone) AW22_1366 ENOG4105CRW Short chain fatty acid transporter AW22_1368 ENOG4107AUC AW22_1369 ENOG4105KBX Transcriptional regulator, TetR family AW22_137 ENOG4108JCI Transcriptional regulator AW22_1370 ENOG4105KPY Small multidrug resistance protein AW22_1371 ENOG4105RXJ AW22_1373 ENOG41069JR AW22_1374 ENOG4105DA5 (ABC) transporter AW22_1378 ENOG4105CZM Major Facilitator AW22_1379 ENOG4107MII Sugar-specific transcriptional regulator TrmB AW22_1381 ENOG4108ISG Major Facilitator AW22_139 ENOG4105DZC cytosine deaminase AW22_1391 ENOG4108IG5 Transcriptional regulator AW22_1393 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AW22_1396 ENOG4108IBT Inherit from COG: transposase AW22_1399 ENOG410874W AraC family transcriptional regulator AW22_1400 ENOG41082W1 Cupin 2, conserved barrel domain protein AW22_1403 ENOG4108AEY RNA polymerase sigma factor AW22_1407 ENOG4108JQ1 Dehydrogenase AW22_141 ENOG4105PFC Transcriptional regulator AW22_1410 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AW22_1414 ENOG4106P55 Transcriptional regulator AW22_1416 ENOG4107QR9 Iron-sulfur cluster binding protein AW22_1417 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) AW22_1418 ENOG4105DJB Major Facilitator Superfamily AW22_1419 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AW22_1421 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 AW22_1422 ENOG4108U05 Transcriptional regulator AW22_1425 ENOG4105BZU Histidine kinase AW22_1428 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) AW22_1432 ENOG4105JQZ Methyltransferase AW22_1433 ENOG4105W1Y Transcriptional regulator AW22_1435 ENOG4105C88 aminopeptidase AW22_1438 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AW22_144 ENOG4105KBX Transcriptional regulator, TetR family AW22_1440 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase AW22_1441 ENOG4108NNI Beta-lactamase domain-containing protein AW22_1446 ENOG4105K6H D-cysteine desulfhydrase AW22_1451 ENOG41062D9 Histidine kinase AW22_1452 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW22_1455 ENOG4105IIP Membrane AW22_1457 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW22_1458 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AW22_146 ENOG4108PCX Major Facilitator AW22_1469 ENOG4105F7F Chaperone AW22_1473 ENOG41085FC arsR family transcriptional regulator AW22_1474 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase AW22_1475 ENOG4105D6J arsenicaL-resistance protein AW22_148 ENOG4108XJQ germination protein AW22_1481 ENOG4105DIK (ABC) transporter AW22_1482 ENOG4105CC5 ABC transporter AW22_1483 ENOG4105DSE periplasmic solute binding protein AW22_1484 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AW22_1485 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AW22_1486 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AW22_1489 ENOG4105GPN Uncharacterized conserved protein (DUF2294) AW22_1490 ENOG4108TWJ NADH dehydrogenase subunit 5 AW22_1495 ENOG4105CVP deoxyribo-dipyrimidine photolyase AW22_1496 ENOG4105CVP deoxyribo-dipyrimidine photolyase AW22_1497 ENOG4108606 TspO/MBR family AW22_15 ENOG41082W1 Cupin 2, conserved barrel domain protein AW22_150 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AW22_1501 ENOG4105YA8 Transcriptional regulator AW22_1502 ENOG4106A3M Cytochrome p-450 AW22_151 ENOG4105M59 Phosphodiesterase, mj0936 family AW22_1511 ENOG41061CK Antibiotic biosynthesis monooxygenase AW22_1512 ENOG4105CGH 5'-nucleotidase AW22_1515 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AW22_1518 ENOG4105E2A Dehydrogenase AW22_1533 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AW22_1538 ENOG4105DWD nucleoside recognition domain protein AW22_154 ENOG4108QCI YvbH-like oligomerisation region AW22_1542 ENOG4105FDT acyl-CoA dehydrogenase AW22_1544 ENOG4108ZHR arsR family transcriptional regulator AW22_1545 ENOG4108ZRV stage ii sporulation protein p AW22_1546 ENOG4106N3A copper homeostasis protein cutc AW22_1548 ENOG4107258 Transcriptional regulator AW22_1549 ENOG4105P4J Allophanate hydrolase, subunit 1 AW22_1556 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AW22_1558 ENOG4107RF6 penicillin-binding protein AW22_1565 ENOG4105F1N DNA alkylation repair AW22_1567 ENOG4108IQI permease AW22_1569 ENOG410635A Membrane AW22_1586 ENOG4108XET gCN5-related N-acetyltransferase AW22_1592 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AW22_1595 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AW22_160 ENOG4108IUQ atp-dependent protease AW22_1602 ENOG4105FS7 Transcriptional regulator AW22_1603 ENOG4108TVJ Nitroreductase AW22_1612 ENOG4105CH6 catalase AW22_1613 ENOG4105C8Y Acetylornithine aminotransferase AW22_1615 ENOG4105CKK Glycosyl transferase, family 2 AW22_1624 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AW22_1630 ENOG41068WN AW22_1635 ENOG4108WCX response regulator AW22_1637 ENOG41090T1 Membrane AW22_164 ENOG4105K56 Transcriptional regulator AW22_1640 ENOG4105VMP Transcriptional regulator AW22_1642 ENOG4105G6Z alkaline phosphatase AW22_1643 ENOG4105ECK Fatty Acid Desaturase AW22_1644 ENOG4105E0Y RtcB Protein AW22_1646 ENOG4107258 Transcriptional regulator AW22_1648 ENOG4105II7 pyrroline-5-carboxylate reductase AW22_1649 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AW22_1655 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) AW22_1660 ENOG41061GT Aldolase AW22_1662 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) AW22_1663 ENOG4105DKT Transcriptional regulator AW22_1665 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane AW22_1667 ENOG4105D4B ABC, transporter AW22_1670 ENOG4108JUB Transcriptional regulator AW22_1671 ENOG4105J5T Amp-dependent synthetase and ligase AW22_1672 ENOG4105E39 Enoyl-CoA hydratase AW22_1673 ENOG4105CY2 Citrate transporter AW22_1675 ENOG41069ER domain protein AW22_1682 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AW22_1684 ENOG4105CIH Imidazole acetol-phosphate transaminase AW22_1688 ENOG41082JN Transcriptional regulator AW22_1689 ENOG4105EYF MMPL domain protein AW22_169 ENOG4105D52 delta-aminolevulinic acid dehydratase AW22_1691 ENOG4105C5H ABC transporter AW22_1692 ENOG4105E0M Sulfatase AW22_1693 ENOG4108ZCF integral membrane protein AW22_1708 ENOG4108AQF aminoglycoside N(3)-acetyltransferase AW22_171 ENOG41068KH stage VI sporulation protein D AW22_1712 ENOG4105E09 nadh pyrophosphatase AW22_1715 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein AW22_1716 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AW22_1717 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AW22_1719 ENOG4105C02 permease AW22_1727 ENOG4105DVE abc transporter atp-binding protein AW22_173 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AW22_1730 ENOG4108ZMI UPF0477 protein AW22_1733 ENOG4105CHM Aminotransferase AW22_1739 ENOG41089UC methyltransferase, type 11 AW22_174 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AW22_1742 ENOG4107BMA Transglycosylase associated protein AW22_1746 ENOG4106K7D Major facilitator family transporter AW22_1747 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AW22_1758 ENOG4105EPR degv family AW22_1760 ENOG4105DVH amino acid AW22_1761 ENOG4105DPN Oligoendopeptidase f AW22_1767 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW22_1768 ENOG4105BZU Histidine kinase AW22_1769 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) AW22_1778 ENOG4105DTQ mandelate racemase muconate lactonizing AW22_178 ENOG4105DFF Rod shape-determining protein mreb AW22_1781 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AW22_1782 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AW22_1785 ENOG4107T5V SNARE associated Golgi AW22_179 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AW22_1791 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein AW22_1793 ENOG41080HI glycine oxidase AW22_1794 ENOG4105CTU Proline racemase AW22_1795 ENOG4105CTU Proline racemase AW22_1796 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AW22_1797 ENOG4105C26 Dehydrogenase AW22_1798 ENOG4105BZG amino acid carrier protein AW22_1801 ENOG4108M1A Chitin-binding protein AW22_1810 ENOG4105C9U ATP-dependent DNA helicase RecQ AW22_1814 ENOG4105EEM helicase AW22_1818 ENOG4108Z7F N-acetyltransferase AW22_182 ENOG4107QMS site-determining protein AW22_1824 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AW22_1825 ENOG4107YB6 acetyltransferase, (GNAT) family AW22_1826 ENOG4105MSB protein, conserved in bacteria AW22_1827 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AW22_1830 ENOG4108M1A Chitin-binding protein AW22_1831 ENOG41082BV acetyltransferase AW22_1832 ENOG4105E66 phosphoriboisomerase A AW22_1837 ENOG4108IJ7 Glycine betaine AW22_1838 ENOG4107SQ8 Glycine betaine AW22_1842 ENOG4108TIT dATP pyrophosphohydrolase AW22_1844 ENOG4105DBI uridine monophosphokinase AW22_1845 ENOG4105RHY Pfam:UPF0157 AW22_1846 ENOG4105E1F short-chain dehydrogenase reductase AW22_1848 ENOG4107RUY (E1 component), alpha subunit AW22_1850 ENOG4107QKR Dehydrogenase AW22_1854 ENOG41062ES Transcriptional regulator AW22_1858 ENOG4105E98 transcriptional regulator DeoR family AW22_1859 ENOG4108MK9 spermidine N(1)-acetyltransferase AW22_186 ENOG4105C03 ribonuclease AW22_1862 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AW22_1867 ENOG4107Z3H Transcriptional regulator, TetR family AW22_1874 ENOG4105MSI germination protein ypeb AW22_188 ENOG4105X36 (ribosomal) protein AW22_1885 ENOG4105FDR Membrane AW22_1887 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AW22_1888 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) AW22_1894 ENOG4108IUM Glycogen debranching enzyme AW22_1898 ENOG4105PAD Hydrolase AW22_1903 ENOG4107VFR oxidoreductase AW22_1910 ENOG4105PKS Excinuclease abc c subunit domain protein AW22_1917 ENOG4105KWG Pfam:DUF1696 AW22_1918 ENOG4108NRW Phospholipase, patatin family AW22_1923 ENOG4108XI2 Domain of unknown function (DUF1963) AW22_1925 ENOG4107TB6 phosphoglycerate mutase AW22_193 ENOG4105EWM Histidine kinase AW22_1930 ENOG4108Z4K mutator MutT protein AW22_1931 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AW22_1932 ENOG4105E09 nadh pyrophosphatase AW22_1933 ENOG4105FCD Major Facilitator AW22_1940 ENOG4107Y9U Membrane AW22_1945 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AW22_1949 ENOG4107Y80 Major Facilitator superfamily AW22_1952 ENOG4108V4B ThiJ pfpI AW22_1958 ENOG4105FQP Beta-lactamase AW22_1960 ENOG4105CHR reductase AW22_1961 ENOG4108IG5 Transcriptional regulator AW22_1962 ENOG4105CJN penicillin-binding protein AW22_1963 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AW22_1964 ENOG4105CB2 alcohol dehydrogenase AW22_1965 ENOG4105RHY Pfam:UPF0157 AW22_1967 ENOG4108HGU Histidine kinase AW22_197 ENOG4105CQC Prephenate dehydratase AW22_1974 ENOG4107RF6 penicillin-binding protein AW22_1975 ENOG4105BZU Histidine kinase AW22_1976 ENOG410667J hydrolase AW22_198 ENOG4108RPX mosc domain containing protein AW22_2000 ENOG4105ETU transcriptional activator (TenA AW22_201 ENOG4108IYU L-aspartate oxidase AW22_2017 ENOG4105DK7 lysyl-tRNA synthetase AW22_2019 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein AW22_202 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AW22_2023 ENOG4105CPQ Dehydrogenase AW22_2032 ENOG4105CUV Homoserine Kinase AW22_2036 ENOG4107Y80 Major Facilitator superfamily AW22_2041 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AW22_2041 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AW22_2049 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AW22_2051 ENOG4105T9C HD domain AW22_2057 ENOG4105DBI uridine monophosphokinase AW22_2058 ENOG4105WCN acetyltransferase AW22_2060 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AW22_2061 ENOG4107QX3 carboxylase AW22_2062 ENOG4105E39 Enoyl-CoA hydratase AW22_2063 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AW22_2064 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit AW22_2065 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AW22_2066 ENOG4105C1G acyl-Coa dehydrogenase AW22_207 ENOG41082BM Transcriptional regulator, arsr family AW22_2070 ENOG4105D7V transposase AW22_2071 ENOG4107RGJ metallophosphoesterase AW22_2073 ENOG4107RF6 penicillin-binding protein AW22_2074 ENOG4107RF6 penicillin-binding protein AW22_2076 ENOG4105EMN RNA polymerase sigma factor AW22_2080 ENOG4105CIN aminoacyl-histidine dipeptidase AW22_2086 ENOG41090HR transcriptional regulator AW22_2087 ENOG4107RA9 decarboxylase AW22_2102 ENOG4105VTR Integrase AW22_2103 ENOG4107RA9 decarboxylase AW22_2105 ENOG41088CC tellurite resistance protein tehB AW22_2109 ENOG4108RZE Tetr family transcriptional regulator AW22_211 ENOG4108HUF Transporter AW22_2111 ENOG4105C1J atp-dependent rna helicase AW22_2114 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AW22_2119 ENOG4107STF Involved in phosphonate degradation (By similarity) AW22_2121 ENOG4105RD7 BadF BadG BcrA BcrD AW22_2126 ENOG4105F32 YngK protein AW22_2131 ENOG4108KPJ rna polymerase sigma factor AW22_2134 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AW22_214 ENOG41061AI Protein of unknown function (DUF2905) AW22_2141 ENOG4108JCI Transcriptional regulator AW22_2145 ENOG4105BZ1 (ABC) transporter AW22_2146 ENOG4105BZ1 (ABC) transporter AW22_2149 ENOG4108RPX mosc domain containing protein AW22_2150 ENOG4105DND Transcriptional regulator AW22_2153 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AW22_2154 ENOG4107V2S Transcriptional regulator AW22_217 ENOG4105VIE preprotein translocase, subunit YajC AW22_219 ENOG4108QG2 Membrane AW22_2199 ENOG4107QPV Serine Threonine protein kinase AW22_220 ENOG4105CKP Polysaccharide Biosynthesis Protein AW22_2201 ENOG4105KRN Transcriptional regulator, abrb family AW22_2216 ENOG4105C2M dna polymerase I AW22_2217 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AW22_222 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AW22_223 ENOG41076HS cation diffusion facilitator family transporter AW22_2239 ENOG4105VEQ Cold shock protein AW22_224 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AW22_2241 ENOG41068WN AW22_2242 ENOG41089UC methyltransferase, type 11 AW22_2244 ENOG4105C1Q protoporphyrinogen oxidase AW22_2250 ENOG4105WCN acetyltransferase AW22_2255 ENOG4105EYF MMPL domain protein AW22_2257 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AW22_226 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AW22_2260 ENOG41081I9 integral membrane protein AW22_2266 ENOG4108D32 Methyltransferase AW22_2272 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AW22_2274 ENOG4105C19 ABC transporter AW22_2276 ENOG4105C22 threonyL-tRNA synthetase AW22_2277 ENOG4105FE9 pseudouridine synthase AW22_2281 ENOG4105BZG amino acid carrier protein AW22_2285 ENOG4105K70 DNA-binding protein AW22_2288 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW22_2289 ENOG4105WQT MbtH domain protein AW22_2290 ENOG4105CEY Amp-dependent synthetase and ligase AW22_2291 ENOG4105WQI isochorismatase AW22_2292 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AW22_2293 ENOG4105E4F Isochorismate synthase AW22_2294 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AW22_2295 ENOG4105FCD Major Facilitator AW22_2300 ENOG4107RFY SbcCD D subunit AW22_2303 ENOG4105E39 Enoyl-CoA hydratase AW22_2304 ENOG4105N14 lysine exporter protein LysE YggA AW22_2306 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AW22_2307 ENOG4105C1G acyl-Coa dehydrogenase AW22_2308 ENOG4105CR4 methylisocitrate lyase AW22_2309 ENOG4105DXD 2-methylcitrate dehydratase AW22_231 ENOG4105CUZ uba thif-type nad fad binding protein AW22_2311 ENOG4105W8X HesB YadR YfhF-family protein AW22_2312 ENOG4105CZM Major Facilitator AW22_2314 ENOG4105BZ4 penicillin-binding protein AW22_232 ENOG4108VCI transcription factor, rsfa family AW22_2325 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AW22_233 ENOG4105D1H recombination factor protein RarA AW22_2337 ENOG4105SZ6 Thioredoxin AW22_2338 ENOG410841Q phosphoesterase PA-phosphatase related protein AW22_2340 ENOG4108N23 SpoOM-related protein AW22_2348 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AW22_2349 ENOG4108JUB Transcriptional regulator AW22_235 ENOG4105C3J Cysteine desulfurase AW22_2350 ENOG4108TSC N-acetyltransferase AW22_2351 ENOG4107S4Y M20 DapE family protein YgeY AW22_2354 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AW22_2359 ENOG4105C37 (CBS) domain AW22_2366 ENOG4105E90 ABC transporter AW22_2367 ENOG4108IJ8 ABC transporter AW22_2373 ENOG4105CMG Carbohydrate kinase AW22_2374 ENOG4105CMG Carbohydrate kinase AW22_238 ENOG4105C7H Helicase, RecD TraA family AW22_2380 ENOG4106KNT transcriptional regulator AW22_2381 ENOG4105WH1 Two component transcriptional regulator luxr family AW22_2382 ENOG4105BZU Histidine kinase AW22_2383 ENOG4105D8X mechanosensitive ion channel AW22_239 ENOG41060CR AW22_2390 ENOG4105F0I Aminotransferase AW22_2391 ENOG4108MES Periplasmic binding protein AW22_2395 ENOG4105CAQ asparagine synthetase AW22_2396 ENOG4107Y70 Heat shock protein AW22_2397 ENOG4108KF3 Electron transport protein SCO1 SenC AW22_2398 ENOG4105E8R UPF0173 metal-dependent hydrolase AW22_2399 ENOG4108RCR degv family AW22_24 ENOG4105DC7 peptidase M24 AW22_2401 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AW22_2403 ENOG4108UT2 hemolysin iii AW22_2404 ENOG4105E9Q Acyl-transferase AW22_2406 ENOG4107RVG penicillin-binding protein AW22_2410 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) AW22_2414 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 AW22_2419 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase AW22_242 ENOG4105C02 permease AW22_2420 ENOG4105KD7 acetyltransferase AW22_2423 ENOG4105C0A alcohol dehydrogenase AW22_2424 ENOG4105CY2 Citrate transporter AW22_2425 ENOG4107XGZ Hydrolase AW22_2429 ENOG4105C8J )-transporter AW22_2432 ENOG41062D9 Histidine kinase AW22_2433 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW22_2434 ENOG4107QPK )-transporter AW22_2435 ENOG4105BZW Glycerate kinase AW22_2459 ENOG4107EV6 Inherit from COG: YD repeat protein AW22_2464 ENOG4105EC2 ftsk spoIIIe AW22_2468 ENOG4105C5S asparaginyl-tRNA synthetase AW22_2469 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AW22_2477 ENOG4107YX5 Pfam:DUF548 AW22_248 ENOG4105HHA aminodeoxychorismate lyase AW22_2483 ENOG4108UUM single-stranded DNA-binding protein AW22_2486 ENOG4105C5H ABC transporter AW22_249 ENOG4108VQJ O-methyltransferase AW22_2492 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AW22_250 ENOG4105XYU peptidase (U32 family) AW22_2501 ENOG4105MCT stage V sporulation protein S AW22_2508 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) AW22_2509 ENOG4108IFG nitrite reductase, (NAD(P)H) AW22_251 ENOG4105CFP Peptidase U32 AW22_2510 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit AW22_2511 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AW22_2512 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AW22_2513 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AW22_2517 ENOG4108ZAF Molybdopterin AW22_2518 ENOG4105CVM Molybdenum cofactor synthesis domain protein AW22_2519 ENOG4105D06 uba thif-type nad fad binding protein AW22_2520 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AW22_2521 ENOG4107V6Q Cyclic nucleotide-binding domain AW22_2523 ENOG4105R3A Nitrate reductase AW22_2524 ENOG4108IUE nitrate reductase beta subunit AW22_2528 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AW22_2531 ENOG4108V06 Glutathione peroxidase AW22_2533 ENOG4105CNW domain protein AW22_2536 ENOG4105EMN RNA polymerase sigma factor AW22_2537 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AW22_2539 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily AW22_254 ENOG4107XRG penicillin-binding protein AW22_2540 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) AW22_2544 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AW22_2549 ENOG4105KBJ sporulation protein ytfj AW22_2565 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AW22_2571 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AW22_2572 ENOG4108JYZ YitT family AW22_2573 ENOG41087PP glycosyltransferase MGT family AW22_2576 ENOG4107RBS Methyltransferase AW22_2577 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AW22_2579 ENOG4108X4Q Hydrolase AW22_2581 ENOG41069HH 4-oxalocrotonate tautomerase AW22_2587 ENOG4105KME endoribonuclease L-psp AW22_2590 ENOG4105U1N riboflavin AW22_2592 ENOG4105EFA 4-hydroxyphenylacetate AW22_2596 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AW22_2598 ENOG4108VXD carboxy-peptidase AW22_260 ENOG4105C28 cystathionine AW22_2600 ENOG4108ZRV stage ii sporulation protein p AW22_2603 ENOG4108Z7R Chaperone CsaA AW22_2607 ENOG4105C37 (CBS) domain AW22_2608 ENOG4105SXS Protein of unknown function (DUF456) AW22_261 ENOG4108EKI Dehydrogenase AW22_2612 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AW22_2613 ENOG4108S4H thioesterase Superfamily protein AW22_2615 ENOG4108PJD permease AW22_2618 ENOG4107T5V SNARE associated Golgi AW22_2622 ENOG4105CVJ phosphoglycerate mutase AW22_2627 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AW22_2629 ENOG4105K4T epimerase AW22_263 ENOG4108V5C ABC transporter AW22_2631 ENOG4105DSE periplasmic solute binding protein AW22_2632 ENOG4108IBT Inherit from COG: transposase AW22_2636 ENOG4105CKI cobalamin synthesis protein AW22_2637 ENOG4107QM2 Aldo Keto reductase AW22_264 ENOG4105S6R Iron-hydroxamate transporter permease subunit AW22_2641 ENOG4105DEN Luciferase family AW22_2644 ENOG4108WPJ Ferritin-like domain AW22_2645 ENOG4108K88 Membrane AW22_2648 ENOG4105C8Q Methyl-accepting chemotaxis AW22_2653 ENOG4107XZQ multidrug resistance protein AW22_2654 ENOG4107SET aldo keto reductase AW22_2655 ENOG4105YVS arsR family transcriptional regulator AW22_2657 ENOG4105KRN Transcriptional regulator, abrb family AW22_2667 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AW22_2668 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AW22_2670 ENOG4105YWU small acid-soluble spore protein AW22_2671 ENOG4108WBH protein TIM barrel AW22_2674 ENOG4105CEY Amp-dependent synthetase and ligase AW22_2675 ENOG4105DUU IucA IucC family protein AW22_2677 ENOG4105VRR gCN5-related N-acetyltransferase AW22_2678 ENOG4105KT7 mgtC SapB transporter AW22_2680 ENOG4107VMI polysaccharide deacetylase AW22_2681 ENOG4105BZU Histidine kinase AW22_2682 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AW22_2684 ENOG4108KGH TRANSCRIPTIONal AW22_2689 ENOG4105D6E homoserine dehydrogenase AW22_2693 ENOG4108ZJ4 polysaccharide deacetylase AW22_2694 ENOG41075D4 Aminoglycoside 6-adenylyltransferase AW22_2695 ENOG4108VQJ O-methyltransferase AW22_2698 ENOG4105BZU Histidine kinase AW22_2699 ENOG4105EFI regulatoR AW22_2700 ENOG4105BZ1 (ABC) transporter AW22_2707 ENOG4108JJ8 (ABC) transporter AW22_2708 ENOG4108JJ9 ABC, transporter AW22_2709 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AW22_2710 ENOG4105C4M (Ubiquinol oxidase) subunit I AW22_2714 ENOG4105MDS 4-oxalocrotonate tautomerase AW22_2716 ENOG4105EGI Transcriptional regulator AW22_2718 ENOG4105C32 Amino acid ABC transporter (Permease) AW22_2719 ENOG4108IV0 ABC, transporter AW22_272 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AW22_2720 ENOG4105C0Z ABC transporter AW22_2722 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AW22_2723 ENOG4108Z7G MaoC domain protein dehydratase AW22_2727 ENOG4105CKI cobalamin synthesis protein AW22_2729 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AW22_2730 ENOG4106F5Q Membrane AW22_2731 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AW22_2733 ENOG4108TVJ Nitroreductase AW22_2734 ENOG4107ZXU DSBA oxidoreductase AW22_2735 ENOG4108Z40 Transcriptional regulator AW22_2736 ENOG4105GZI Transcriptional regulator AW22_2737 ENOG4107RT3 EamA-like transporter family AW22_2739 ENOG4105KTB nuclear export factor GLE1 AW22_274 ENOG4105MIR Phenylalanine 4-monooxygenase AW22_2740 ENOG4108T5E Copper resistance protein AW22_275 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AW22_2754 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AW22_2755 ENOG4105DY8 decarboxylase AW22_2768 ENOG4107R16 Multicopper oxidase AW22_2769 ENOG4107RAQ aminopeptidase AW22_2774 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AW22_2775 ENOG4105D9N nucleoside AW22_2777 ENOG4107RHR regulatoR AW22_2779 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AW22_2788 ENOG4105C0X amino acid AW22_2790 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AW22_2793 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) AW22_2798 ENOG41068WN AW22_2806 ENOG4108IBT Inherit from COG: transposase AW22_281 ENOG4108MUZ hydrolase AW22_2810 ENOG4105CYC Transferase AW22_2811 ENOG4105DY9 regulatoR AW22_2815 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AW22_2816 ENOG4105C6X Major Facilitator AW22_2820 ENOG4105C7B Threonine dehydratase AW22_2822 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AW22_2824 ENOG4105C7K acetolactate synthase AW22_2825 ENOG4105CM2 brancheD-chain amino acid aminotransferase AW22_2826 ENOG4105CHR reductase AW22_2827 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AW22_283 ENOG4105G6Z alkaline phosphatase AW22_2831 ENOG4106KE4 Dehydrogenase AW22_2834 ENOG4105H67 Protein of unknown function (DUF421) AW22_2835 ENOG4105X5K response regulator receiver protein AW22_2837 ENOG4105C8J )-transporter AW22_2841 ENOG4105C6T cysteine synthase AW22_2842 ENOG4105EU0 Major facilitator Superfamily AW22_2844 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AW22_2847 ENOG4105DXI Major Facilitator superfamily AW22_2848 ENOG4105CSR polyphosphate kinase 2 AW22_2858 ENOG4105FVX AW22_286 ENOG4108TVJ Nitroreductase AW22_2870 ENOG4105C6K Malic enzyme AW22_2871 ENOG4108IJ0 Aspartate ammonia-lyase AW22_2873 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AW22_2877 ENOG4105CJ1 ABC, transporter AW22_2884 ENOG4106BRA Membrane AW22_2890 ENOG4107QIV Cytochrome c biogenesis protein AW22_2894 ENOG4105EC3 peptidase S51, dipeptidase E AW22_2895 ENOG4107QJQ Mate efflux family protein AW22_2898 ENOG4105C9Q fumarate hydratase class II AW22_2899 ENOG4105DFD Na H antiporter AW22_290 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW22_2902 ENOG4108PJD permease AW22_2903 ENOG4105CKI cobalamin synthesis protein AW22_2904 ENOG4108UZ3 Transporter AW22_2905 ENOG4105DRR Transcriptional regulator, GntR family AW22_2907 ENOG4105PGM cation diffusion facilitator family transporter AW22_2911 ENOG4105CAQ asparagine synthetase AW22_2913 ENOG4105K56 Transcriptional regulator AW22_2916 ENOG4105CVJ phosphoglycerate mutase AW22_2926 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr AW22_2929 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AW22_293 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase AW22_2930 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component AW22_2932 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AW22_2933 ENOG4105DUM transcriptional regulator, lysR family AW22_2938 ENOG4105KAC Antibiotic biosynthesis monooxygenase AW22_294 ENOG4105CQW ribosome biogenesis GTPase YqeH AW22_2944 ENOG41062JF Transcriptional regulator AW22_2949 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AW22_2950 ENOG4105KTQ flagellar basal-body rod protein AW22_2951 ENOG4105FZW flagellar biosynthesis regulator FlhF AW22_2952 ENOG4105D7B Flagellar biosynthesis protein flha AW22_2953 ENOG4105D00 flagellar biosynthetic protein flhB AW22_2955 ENOG4105VS8 Flagellar biosynthetic protein fliq AW22_2956 ENOG4105CN7 Flagellar biosynthetic protein FliP AW22_2958 ENOG4105DD5 Flagellar motor switch protein AW22_2959 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AW22_296 ENOG410812S Rna-binding protein AW22_2961 ENOG4105E4C Lytic transglycosylase catalytic AW22_2962 ENOG4105I03 Flagellin AW22_2963 ENOG4105I03 Flagellin AW22_2965 ENOG4107R88 Chemotaxis protein (CheV) AW22_2968 ENOG4105BZE flagellar hook protein, FlgE AW22_2974 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AW22_2975 ENOG4107U2N Flagellar M-ring protein AW22_2976 ENOG41075Z6 flagellar hook-basal body complex protein fliE AW22_2977 ENOG4108ZC9 flagellar basal-body rod protein flgc AW22_2978 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AW22_298 ENOG4108WF2 Metal Dependent Phosphohydrolase AW22_2981 ENOG4105DTS flagellar hook-associated AW22_2982 ENOG4105DTJ flagellar hook-associated protein AW22_2983 ENOG4105E1Q flagellar hook-associated protein AW22_2987 ENOG4105BZU Histidine kinase AW22_2990 ENOG4105DD5 Flagellar motor switch protein AW22_2991 ENOG4105CBS Chea signal transduction histidine kinase AW22_2992 ENOG4107YTP response regulator receiver protein AW22_2993 ENOG4105ER2 Ompa motb domain protein AW22_2994 ENOG4107R0U MotA TolQ exbB proton channel AW22_2996 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AW22_300 ENOG4105DXX methyltransferase AW22_3007 ENOG41080C8 DUF218 domain AW22_3008 ENOG4105H67 Protein of unknown function (DUF421) AW22_3010 ENOG4108Z5V transcriptional regulator, merr family AW22_3011 ENOG4105CN5 Metallo-Beta-Lactamase AW22_3012 ENOG4107RWR Sodium hydrogen exchanger AW22_3014 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AW22_302 ENOG4105KQC Competence protein AW22_3027 ENOG41081VK Ribonuclease AW22_303 ENOG4108UK2 deaminase AW22_3031 ENOG4108SZE gCN5-related N-acetyltransferase AW22_304 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AW22_3045 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AW22_306 ENOG4105TQK DNA polymerase iii, delta' subunit AW22_3061 ENOG4105CAR Terminase, large subunit AW22_3076 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW22_3086 ENOG4105CFF transcriptional regulator AW22_3094 ENOG4106032 Glutathionylspermidine synthase AW22_3098 ENOG4105KHC sulfurtransferase AW22_31 ENOG4105SFS phosphoesterase RecJ domain protein AW22_3100 ENOG4108W0I acetyltransferase AW22_3102 ENOG410890F Dynamin family AW22_3104 ENOG4105DHF Membrane AW22_3105 ENOG4105C2W permease AW22_3107 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AW22_311 ENOG4105KVH Transcriptional regulator AW22_3110 ENOG4105CTD carboxy-peptidase AW22_3111 ENOG4105DVT helicase AW22_3113 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AW22_312 ENOG4105CSA Coproporphyrinogen iii oxidase AW22_3124 ENOG4105BZ4 penicillin-binding protein AW22_3126 ENOG4105CSM endonuclease III AW22_3130 ENOG4105YAC AW22_3131 ENOG4105DVT helicase AW22_3138 ENOG4105CPK Glycosyl transferase (Group 1 AW22_3139 ENOG4105FJR Lmbe family AW22_314 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AW22_3142 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase AW22_3143 ENOG4108JYZ YitT family AW22_3149 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit AW22_3150 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AW22_3151 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) AW22_3154 ENOG41068YB TPR repeat-containing protein AW22_3155 ENOG4105CIH Imidazole acetol-phosphate transaminase AW22_3159 ENOG4105EAH synthase AW22_3161 ENOG4105XXQ heptaprenyl diphosphate synthase component I AW22_3164 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) AW22_3170 ENOG41065D1 AW22_3171 ENOG4105S2F AW22_3178 ENOG4107RB3 L-asparaginase AW22_3179 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase AW22_318 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AW22_3184 ENOG4108S6Z Negative regulator of genetic competence AW22_3185 ENOG4107X2D transcriptional regulator, merr family AW22_3186 ENOG4107RGJ metallophosphoesterase AW22_3188 ENOG4105I7S Abortive infection protein AW22_3189 ENOG4105C9U ATP-dependent DNA helicase RecQ AW22_319 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AW22_3192 ENOG4108SAX Membrane AW22_3194 ENOG41063SB peptidase AW22_3195 ENOG4108WBT adenosyltransferase AW22_3196 ENOG4105BZU Histidine kinase AW22_3197 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW22_3198 ENOG4105CRE cytochrome C AW22_3199 ENOG4107TWT Cytochrome c biogenesis protein AW22_3201 ENOG4105FE9 pseudouridine synthase AW22_3203 ENOG4108JIC nucleoside recognition domain protein AW22_3204 ENOG4105DZ1 carboxypeptidase AW22_3205 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AW22_321 ENOG4105KTH gatB Yqey AW22_3212 ENOG4105BZU Histidine kinase AW22_3215 ENOG4105I3N Conserved Protein AW22_3216 ENOG4105BZU Histidine kinase AW22_3219 ENOG4105BZ4 penicillin-binding protein AW22_322 ENOG41068P3 sporulation protein YqfC AW22_3220 ENOG4107GRR phosphate transport regulator AW22_3221 ENOG4105CJ3 phosphate transporter AW22_3231 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AW22_3235 ENOG4105WH1 Two component transcriptional regulator luxr family AW22_3236 ENOG4105ENE Histidine kinase AW22_324 ENOG4105C9A Phoh family AW22_3240 ENOG4105DFD Na H antiporter AW22_3244 ENOG4105C8J )-transporter AW22_3245 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AW22_3246 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AW22_3247 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AW22_3249 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AW22_325 ENOG4105CTJ Metal Dependent Phosphohydrolase AW22_3250 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AW22_3254 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AW22_3256 ENOG4105E0M Sulfatase AW22_3257 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AW22_3260 ENOG4107RVV histidinol phosphate phosphatase, hisj family AW22_327 ENOG4107YR5 Diacylglycerol kinase AW22_3275 ENOG4108ZP8 Acetolactate synthase small subunit AW22_3276 ENOG4105C7K acetolactate synthase AW22_3277 ENOG4105CM2 brancheD-chain amino acid aminotransferase AW22_328 ENOG4105KG3 cytidine deaminase AW22_3282 ENOG4105KBJ sporulation protein ytfj AW22_3283 ENOG41063Y9 AW22_3284 ENOG4105CZN Potassium uptake protein AW22_329 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AW22_3290 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AW22_3291 ENOG4107QMU Mate efflux family protein AW22_3298 ENOG4105NQC Flavodoxin AW22_33 ENOG4105VV2 AW22_3303 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AW22_3305 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AW22_3306 ENOG4105EA8 2-Nitropropane dioxygenase AW22_3307 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AW22_3315 ENOG4105CJ1 ABC, transporter AW22_3317 ENOG4105CZV ABC transporter AW22_3318 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AW22_3319 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AW22_3320 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AW22_3321 ENOG41079K6 HNH endonuclease AW22_3322 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AW22_3323 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AW22_3331 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AW22_3332 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase AW22_3334 ENOG4105BZU Histidine kinase AW22_3336 ENOG4106DF1 AW22_3338 ENOG41090MY MarR family Transcriptional regulator AW22_3339 ENOG4105BZU Histidine kinase AW22_334 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AW22_3341 ENOG4105PXI polysaccharide deacetylase AW22_3343 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) AW22_3346 ENOG4105E98 transcriptional regulator DeoR family AW22_335 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW22_3350 ENOG4107RCV ABC transporter, permease AW22_3351 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AW22_3352 ENOG4105C4Y ABC transporter AW22_3356 ENOG4105MWK D-amino acid dehydrogenase, small subunit AW22_3358 ENOG4105CHR reductase AW22_3362 ENOG4108Z7G MaoC domain protein dehydratase AW22_3363 ENOG410681C small acid-soluble spore protein AW22_3364 ENOG4105CZN Potassium uptake protein AW22_3365 ENOG4107TS3 membrane protein, TerC AW22_3366 ENOG4108QTI )-transporter AW22_3368 ENOG4106A3R peptidase AW22_3372 ENOG4105JXH GntR family transcriptional regulator AW22_3373 ENOG4105BZU Histidine kinase AW22_3374 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW22_3377 ENOG4105CQB FAD linked oxidase domain protein AW22_3378 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AW22_3379 ENOG4105K4I Scp-like extracellular AW22_338 ENOG4105EGD dinuclear metal center protein, YbgI family AW22_3381 ENOG4108YBP pseudouridine synthase AW22_3383 ENOG4105EYF MMPL domain protein AW22_3385 ENOG4107RUE extracellular solute-binding protein family 1 AW22_3386 ENOG4105D38 putrescine abc transporter AW22_3387 ENOG4105F38 ABC transporter, permease AW22_3389 ENOG4105C26 Dehydrogenase AW22_3395 ENOG4105VFR signal peptidase AW22_3396 ENOG4105DZ1 carboxypeptidase AW22_34 ENOG4105C0B DNA polymerase III (alpha subunit) AW22_3401 ENOG41069I7 AW22_3416 ENOG4105VZ8 Transcriptional regulator AW22_3418 ENOG4105C7S Dehydrogenase AW22_3422 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AW22_343 ENOG41069ZM Protein of unknown function (DUF2624) AW22_3437 ENOG4105DDQ anthranilate synthase AW22_3438 ENOG4105CRQ synthase (Component I) AW22_3439 ENOG4105CK7 Sodium proline symporter AW22_344 ENOG4108JYZ YitT family AW22_345 ENOG4105FDK ABC transporter AW22_3454 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase AW22_3456 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AW22_3457 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AW22_3461 ENOG4107TVC Glycosyl transferase, family 2 AW22_3465 ENOG4105K64 Glycosyl transferase, family 2 AW22_3469 ENOG4105EMS pseudouridine synthase AW22_347 ENOG4105N80 Ferric uptake regulator, Fur family AW22_3470 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AW22_3473 ENOG4105MIX Adenylate cyclase AW22_3474 ENOG4108Z18 K06886 hemoglobin AW22_3477 ENOG4105DPN Oligoendopeptidase f AW22_3479 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AW22_3481 ENOG4108ZCF integral membrane protein AW22_3485 ENOG4105UQX Mate efflux family protein AW22_3486 ENOG4108JQ7 (ABC) transporter AW22_3488 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AW22_3489 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AW22_3492 ENOG4105C31 Tryptophanyl-tRNA synthetase AW22_3495 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AW22_3496 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AW22_35 ENOG4105C6K Malic enzyme AW22_3501 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AW22_3503 ENOG4108KP7 hydrolase AW22_3505 ENOG41073B9 AW22_3506 ENOG4107AYK membrAne AW22_3508 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AW22_3510 ENOG4105QNR S1 RNA binding domain protein AW22_3514 ENOG4105BZU Histidine kinase AW22_3515 ENOG4105CH6 catalase AW22_3516 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AW22_3517 ENOG4105CAQ asparagine synthetase AW22_352 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AW22_3522 ENOG4105ERH Fumarylacetoacetate hydrolase AW22_3536 ENOG4105XVF Competence transcription factor AW22_3539 ENOG4105VEQ Cold shock protein AW22_354 ENOG4107RF6 penicillin-binding protein AW22_3542 ENOG4107QP3 malate synthase g AW22_3543 ENOG4105ZU5 s-layer protein AW22_3547 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 AW22_355 ENOG4105PWN phosphate abc transporter AW22_3552 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AW22_3554 ENOG41086D8 Transcriptional regulator AW22_3555 ENOG4108AEY RNA polymerase sigma factor AW22_3557 ENOG4107TVP HD domain protein AW22_3559 ENOG4107RN3 metallophosphoesterase AW22_356 ENOG4105C8U phosphate abc transporter AW22_3560 ENOG4105ENX hydrolase AW22_357 ENOG4105E2Z phosphate ABC transporter (Permease AW22_3572 ENOG4105CEY Amp-dependent synthetase and ligase AW22_3574 ENOG4105DF9 Lipoate-protein, ligase AW22_3575 ENOG4108RQ5 Beta-lactamase domain-containing protein AW22_3576 ENOG4106AXD AW22_358 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AW22_3582 ENOG4105ECB domain protein AW22_3585 ENOG4105NA0 Transcriptional regulator AW22_359 ENOG4108UTW Plays a role in the regulation of phosphate uptake AW22_3591 ENOG4105C1Q protoporphyrinogen oxidase AW22_3594 ENOG4105BZ4 penicillin-binding protein AW22_3595 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation AW22_3596 ENOG4105CKV Membrane AW22_3597 ENOG410905X membrane-flanked domain protein AW22_36 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AW22_3603 ENOG4108TVJ Nitroreductase AW22_3608 ENOG4105CKV Membrane AW22_3609 ENOG410905X membrane-flanked domain protein AW22_362 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AW22_3628 ENOG4105K59 histidine triad (HIT) protein AW22_3633 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AW22_3634 ENOG4105EEM helicase AW22_3636 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW22_3637 ENOG4105C57 major facilitator superfamily AW22_364 ENOG4105DKQ ROK family AW22_3642 ENOG4105EMN RNA polymerase sigma factor AW22_3647 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AW22_3650 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AW22_3654 ENOG4108MUZ hydrolase AW22_366 ENOG4105C5X domain protein AW22_3665 ENOG4106D4I domain protein AW22_3666 ENOG4107VRP DNA repair exonuclease AW22_3671 ENOG4108VB1 regulatoR AW22_3672 ENOG4105ENE Histidine kinase AW22_3675 ENOG4105K8R UPF0145 protein AW22_3680 ENOG4105BZU Histidine kinase AW22_3681 ENOG4105BZU Histidine kinase AW22_3682 ENOG4108MJI response regulator AW22_3684 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW22_3686 ENOG4105WN5 stage II sporulation protein AW22_369 ENOG4105C28 cystathionine AW22_3699 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AW22_370 ENOG4105C28 cystathionine AW22_3701 ENOG410780I phosphoprotein phosphatase activity AW22_3704 ENOG410847I Transcriptional regulator, BadM Rrf2 family AW22_3705 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AW22_3706 ENOG4105CMT Dihydroxyacetone kinase AW22_3708 ENOG4105CMT Dihydroxyacetone kinase AW22_3709 ENOG4108NIW Leucine export protein LeuE AW22_3719 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AW22_372 ENOG4105C3R Methionine synthase AW22_3722 ENOG4108IG5 Transcriptional regulator AW22_3723 ENOG4107P5I polyketide synthase AW22_3741 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 AW22_3743 ENOG4105CDU Replicative dna helicase AW22_3756 ENOG4108MRH transcriptional regulatory protein AW22_3758 ENOG4105CSH Transporter AW22_3762 ENOG4105CTU Proline racemase AW22_3766 ENOG4105DER m42 family AW22_3770 ENOG4105CGU Enoyl-CoA hydratase AW22_3772 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AW22_3774 ENOG4106AKK s-layer domain-containing protein AW22_3783 ENOG4105CHH sulfate transporter AW22_3786 ENOG4105D4P Coproporphyrinogen iii oxidase AW22_3787 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AW22_3790 ENOG4107FQX Alpha-acetolactate decarboxylase AW22_3800 ENOG4105BZU Histidine kinase AW22_3805 ENOG410839P AW22_3808 ENOG4105CDA abc transporter atp-binding protein AW22_3809 ENOG4105DRP amino acid AbC transporter AW22_3811 ENOG4105BZ1 (ABC) transporter AW22_3812 ENOG4105BZ1 (ABC) transporter AW22_3813 ENOG4105C26 Dehydrogenase AW22_3815 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AW22_3816 ENOG4105D5Q Arginine ornithine antiporter AW22_3818 ENOG4105CH6 catalase AW22_3819 ENOG4107RKG DJ-1/PfpI family AW22_3820 ENOG4107RKG DJ-1/PfpI family AW22_3822 ENOG4105E5W Transporter AW22_3823 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AW22_3826 ENOG4105KPY Small multidrug resistance protein AW22_3827 ENOG4105KPY Small multidrug resistance protein AW22_3829 ENOG4108YXU transcriptional regulator AsnC family AW22_3838 ENOG4106KNT transcriptional regulator AW22_3840 ENOG4107RWR Sodium hydrogen exchanger AW22_3841 ENOG4105CUB amino acid AW22_3848 ENOG4107T5V SNARE associated Golgi AW22_3855 ENOG4105WEF catalase AW22_3862 ENOG4105C19 ABC transporter AW22_3863 ENOG4107RBB ABC transporter, permease AW22_3864 ENOG41069ER domain protein AW22_3868 ENOG4105VZJ PTS System AW22_3869 ENOG4105VCP PTS System AW22_3870 ENOG4105EMD TRANSCRIPTIONal AW22_3875 ENOG4108KGH TRANSCRIPTIONal AW22_3877 ENOG41087NI Sulfite exporter TauE/SafE AW22_3878 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase AW22_3880 ENOG41085GJ domain protein AW22_3881 ENOG4105VFE sira family AW22_3882 ENOG4107TPS domain protein AW22_3883 ENOG4105VFE sira family AW22_3884 ENOG4105XTG Pfam:DUF156 AW22_3885 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase AW22_3894 ENOG4105ED1 spovr family AW22_3895 ENOG4107Y03 Nitroreductase AW22_3899 ENOG4108B31 Spore germination protein AW22_3906 ENOG4105C5Y PTS System AW22_3910 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AW22_3912 ENOG4105C7N Xanthine uracil vitamin C permease AW22_3914 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AW22_3919 ENOG4108INS Transcriptional regulator AW22_3928 ENOG4105DWF phosphomethylpyrimidine kinase AW22_3929 ENOG4105D06 uba thif-type nad fad binding protein AW22_3932 ENOG41080HI glycine oxidase AW22_3933 ENOG4108VEU Thiamine monophosphate synthase AW22_3935 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AW22_3937 ENOG4105ETU transcriptional activator (TenA AW22_3941 ENOG41080XQ Signal transduction protein with cbs domains AW22_396 ENOG4105C0D helicase AW22_3967 ENOG4105E2Z phosphate ABC transporter (Permease AW22_3968 ENOG4105C8U phosphate abc transporter AW22_3969 ENOG4105CVA phosphate AW22_3970 ENOG4105CE1 Ferrous iron transport protein b AW22_3971 ENOG4105CE1 Ferrous iron transport protein b AW22_3972 ENOG4105CE1 Ferrous iron transport protein b AW22_3973 ENOG4108NHD germination protein AW22_3976 ENOG4105E1V na solute symporter AW22_3977 ENOG4106CAD Protein of unknown function (DUF3311) AW22_3980 ENOG4105E2S oxidase) subunit II AW22_3981 ENOG4105BZ9 Cytochrome C oxidase, subunit I AW22_3986 ENOG4105MA6 gCN5-related N-acetyltransferase AW22_3989 ENOG4105C7N Xanthine uracil vitamin C permease AW22_3990 ENOG4105C85 amino acid AW22_3995 ENOG4105DUX Transporter AW22_3997 ENOG4107D63 AW22_3998 ENOG4105VZ8 Transcriptional regulator AW22_3999 ENOG41069ER domain protein AW22_4000 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AW22_4012 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AW22_4013 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AW22_4014 ENOG4105CNN ABC, transporter AW22_4015 ENOG4105C2J ABC transporter AW22_4017 ENOG4108RVA ribokinase AW22_4018 ENOG4105ETE Transcriptional regulator (LacI family AW22_4019 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW22_402 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AW22_4020 ENOG41067TZ transcriptional regulator, MarR family AW22_4021 ENOG4105CXY transporter AW22_4023 ENOG4108JQ7 (ABC) transporter AW22_4024 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AW22_4026 ENOG4105DEF Extracellular solute-binding protein, family 5 AW22_4028 ENOG41068KF Universal stress protein AW22_4029 ENOG4105CHH sulfate transporter AW22_403 ENOG4105CJ1 ABC, transporter AW22_4032 ENOG4105BZU Histidine kinase AW22_4033 ENOG4105NAE bifunctional deaminase-reductase domain protein AW22_4034 ENOG4105D29 Helix-turn-helix type 11 domain protein AW22_4039 ENOG4108IQI permease AW22_4040 ENOG4105DRP amino acid AbC transporter AW22_4041 ENOG4105EAD ABC transporter AW22_4042 ENOG4105CT1 (ABC) transporter AW22_4043 ENOG4105CDA abc transporter atp-binding protein AW22_4044 ENOG4105BZG amino acid carrier protein AW22_4045 ENOG4105CRN Aminoglycoside phosphotransferase AW22_4048 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AW22_4049 ENOG4105WH1 Two component transcriptional regulator luxr family AW22_4050 ENOG4108XG2 Histidine kinase AW22_4051 ENOG4105E1K spore germination protein AW22_4054 ENOG4105CG3 alpha amylase, catalytic region AW22_4055 ENOG4105C5Y PTS System AW22_4056 ENOG4107414 GntR family transcriptional regulator AW22_4057 ENOG4105D5Q Arginine ornithine antiporter AW22_4058 ENOG4105BZU Histidine kinase AW22_4060 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AW22_4061 ENOG4105GMT ATPase associated with various cellular activities aaa_5 AW22_4062 ENOG4107T89 von Willebrand factor, type A AW22_4064 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) AW22_4065 ENOG4105EXW epimerase dehydratase AW22_4067 ENOG4105DMQ Methyltransferase AW22_4068 ENOG4105E0A ABC, transporter AW22_4069 ENOG4108IHU transport system permease protein AW22_4070 ENOG4105DQ5 transport system permease protein AW22_4071 ENOG4108MES Periplasmic binding protein AW22_4072 ENOG4105DUX Transporter AW22_4075 ENOG4105DAA L-lactate AW22_4076 ENOG4108IJ0 Aspartate ammonia-lyase AW22_4077 ENOG4105C37 (CBS) domain AW22_4078 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AW22_4079 ENOG4105D9N nucleoside AW22_4080 ENOG4108KGH TRANSCRIPTIONal AW22_4081 ENOG41073R8 VanW family AW22_4089 ENOG4105DAP Nicotinate phosphoribosyltransferase AW22_4090 ENOG4105C59 p-type ATPase AW22_4092 ENOG4105CUB amino acid AW22_4096 ENOG4108JB9 formate dehydrogenase AW22_4097 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AW22_4098 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AW22_41 ENOG4105FS0 cytoplasmic membrane protein AW22_410 ENOG41080TC multidrug resistance protein AW22_4100 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW22_4101 ENOG4105BZU Histidine kinase AW22_4103 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AW22_4104 ENOG4108UZ3 Transporter AW22_4106 ENOG4105C6K Malic enzyme AW22_4108 ENOG4108MRH transcriptional regulatory protein AW22_4113 ENOG4105US7 Histidine kinase AW22_4114 ENOG4108STX response regulator AW22_4115 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AW22_4116 ENOG4105BZ7 extracellular solute-binding protein family 1 AW22_4117 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component AW22_4118 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component AW22_4119 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AW22_4120 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AW22_4124 ENOG4105D4T Citrate transporter AW22_4125 ENOG4108V9W transcriptional regulatory protein AW22_4126 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AW22_4128 ENOG4105DZ6 Band 7 protein AW22_4131 ENOG4105C94 Transporter AW22_4134 ENOG4105CYN Serine protein kinase AW22_4137 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AW22_4139 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AW22_414 ENOG4105WZW rhodanese family AW22_4141 ENOG4107ZQN disulfide bond AW22_4142 ENOG4108JQC penicillin-binding protein 1A AW22_4148 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AW22_415 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) AW22_4176 ENOG4105G5W regulator Fur family AW22_4177 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AW22_418 ENOG4105K7K Transcriptional regulator AW22_4181 ENOG4108IUW ABC transporter AW22_4183 ENOG4105CBC glutamate synthase AW22_4184 ENOG4107NBY Membrane AW22_4185 ENOG4105BZ1 (ABC) transporter AW22_4189 ENOG4106BXE AW22_4190 ENOG4105CEN a g-specific adenine glycosylase AW22_4191 ENOG41067AE Membrane-bound metal-dependent hydrolase AW22_4197 ENOG4105ECP epimerase AW22_4198 ENOG4105CI2 imidazolone-5-propionate hydrolase AW22_42 ENOG4108REF Sporulation integral membrane protein ytvi AW22_4202 ENOG4105F1A Pyruvate formate-lyase AW22_4205 ENOG4105C3I Nad-dependent epimerase dehydratase AW22_4206 ENOG4107QQG Dehydrogenase AW22_4212 ENOG4108A04 Beta-lactamase AW22_4214 ENOG4105CSV Glutaminase AW22_422 ENOG4107YBY Hydrolase AW22_423 ENOG4105CBJ Metal-dependent enzyme AW22_4231 ENOG4105UPD Calcium Proton AW22_4232 ENOG410606W general stress protein AW22_4235 ENOG4107ZTW SNARE associated Golgi AW22_4239 ENOG4108IPJ Membrane AW22_4240 ENOG4105C59 p-type ATPase AW22_4241 ENOG4107U9T Pfam:Ribonuclease_BN AW22_4243 ENOG4105KJF protein tyrosine phosphatase AW22_4247 ENOG4108TTB tellurium resistance protein AW22_4248 ENOG4107TS3 membrane protein, TerC AW22_4249 ENOG4106FN3 tellurium resistance protein AW22_4250 ENOG4106FN3 tellurium resistance protein AW22_4251 ENOG4108N0M stress protein AW22_4257 ENOG4105DEU major facilitator superfamily AW22_426 ENOG4105DC7 peptidase M24 AW22_4261 ENOG41062JF Transcriptional regulator AW22_4267 ENOG4105C5H ABC transporter AW22_4271 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AW22_4274 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AW22_4280 ENOG4105CI1 PTS System AW22_4283 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AW22_4284 ENOG4105C8Q Methyl-accepting chemotaxis AW22_4286 ENOG4105EAB amino acid AbC transporter AW22_4287 ENOG4105E5Q amino acid AbC transporter AW22_4288 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AW22_4290 ENOG4107QJZ Glycosyl transferase, family 2 AW22_4293 ENOG4105D2S major facilitator superfamily AW22_4294 ENOG410756H nucleotidyltransferase AW22_4298 ENOG4105BZU Histidine kinase AW22_4302 ENOG4106UIA AW22_4303 ENOG4106UIA AW22_4307 ENOG4108V5C ABC transporter AW22_4308 ENOG4105DQ5 transport system permease protein AW22_4309 ENOG4105EHG Permease protein AW22_431 ENOG4105CD2 stage iii sporulation protein aa AW22_4311 ENOG4107W7X Aldolase AW22_4313 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) AW22_4314 ENOG4105D3R alkyl hydroperoxide reductase AW22_4319 ENOG4105DFD Na H antiporter AW22_432 ENOG4105KR5 Stage iii sporulation protein AW22_4320 ENOG4105DTQ mandelate racemase muconate lactonizing AW22_4323 ENOG4108W15 Protein of unknown function (DUF1456) AW22_4324 ENOG4105BZU Histidine kinase AW22_4326 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AW22_4327 ENOG4105D9N nucleoside AW22_433 ENOG4108CQH stage III sporulation protein AC AW22_4331 ENOG4105KPY Small multidrug resistance protein AW22_4332 ENOG4105C26 Dehydrogenase AW22_4334 ENOG4108JPW Aminotransferase AW22_4335 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AW22_4336 ENOG4105CBD Diacylglycerol kinase AW22_434 ENOG4105KQ4 Stage iii sporulation protein ad AW22_4340 ENOG4107I77 yiaA/B two helix domain AW22_4341 ENOG410834F Transcriptional regulator AW22_4345 ENOG4105D01 (LipO)protein AW22_4346 ENOG4108UMI ABC transporter, permease AW22_4347 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AW22_4348 ENOG4108W2Y isochorismatase AW22_4354 ENOG4105C4R Atp-dependent dna helicase AW22_4359 ENOG4105C12 Phosphoribosylglycinamide synthetase AW22_436 ENOG410644B Stage III sporulation protein af AW22_4361 ENOG4108V3E phosphoribosylglycinamide formyltransferase AW22_4366 ENOG4105VR9 phosphoribosylformylglycinamidine synthase AW22_4368 ENOG4105C83 adenylosuccinate lyase AW22_4369 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AW22_4370 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AW22_4376 ENOG4105SX7 Transporter AW22_4381 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AW22_4395 ENOG4107ZXU DSBA oxidoreductase AW22_44 ENOG4105BZN citrate synthase AW22_4401 ENOG4105BZU Histidine kinase AW22_4403 ENOG4105C7N Xanthine uracil vitamin C permease AW22_4406 ENOG4107EV6 Inherit from COG: YD repeat protein AW22_4409 ENOG4108TYN CAAX amino terminal protease family protein AW22_441 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AW22_4412 ENOG4105C5H ABC transporter AW22_4414 ENOG410801F ribosomal-protein-alanine acetyltransferase AW22_4415 ENOG41072GX Peptidase M22 Glycoprotease AW22_4416 ENOG4105K8N protein family UPF0079, ATPase AW22_442 ENOG4108ZSR alkaline shock protein AW22_4435 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) AW22_4437 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AW22_4438 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein AW22_4441 ENOG4107ZXI Rhomboid family AW22_4443 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AW22_4444 ENOG4105CPF Cell wall formation (By similarity) AW22_4445 ENOG4108SC4 )-transporter AW22_4449 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase AW22_4455 ENOG410667J hydrolase AW22_4456 ENOG4108JQ7 (ABC) transporter AW22_4457 ENOG4105C3U ABC transporter AW22_4458 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AW22_4460 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein AW22_4463 ENOG4105C5H ABC transporter AW22_4467 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) AW22_4469 ENOG4108RE7 deoxyribonuclease AW22_447 ENOG4105CTB Polyprenyl synthetase AW22_4472 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AW22_4476 ENOG4105F6E Acyl-transferase AW22_4483 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family AW22_4484 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AW22_4485 ENOG4105E0C molybdate abc transporter AW22_4487 ENOG4107XDY Nicotinamide Mononucleotide Transporter AW22_4488 ENOG4105II7 pyrroline-5-carboxylate reductase AW22_449 ENOG4105DX0 Hemolysin A AW22_4490 ENOG4108J59 Extracellular solute-binding protein, family 5 AW22_4491 ENOG4108J59 Extracellular solute-binding protein, family 5 AW22_4497 ENOG4108JQ7 (ABC) transporter AW22_4498 ENOG4105C3U ABC transporter AW22_4499 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AW22_45 ENOG4108HMX isocitrate dehydrogenase (NADP) AW22_4500 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AW22_4503 ENOG4105C2C drug resistance transporter, Bcr CflA AW22_4506 ENOG4105IQ5 FAD linked oxidase domain protein AW22_4508 ENOG4105EE1 crotonyl-CoA reductase AW22_4509 ENOG4105D01 (LipO)protein AW22_451 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AW22_4510 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AW22_4511 ENOG4108UMI ABC transporter, permease AW22_4512 ENOG4108PSK reductase AW22_452 ENOG4105S1Z Stage IV sporulation protein B AW22_4520 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AW22_4522 ENOG4105CMG Carbohydrate kinase AW22_4528 ENOG4107U5W ybbr family AW22_4529 ENOG4105C8B TIGR00159 family AW22_453 ENOG4107QQR Sporulation AW22_4546 ENOG4108NMV polysaccharide deacetylase AW22_4549 ENOG4105D1F ATP-binding protein AW22_4554 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AW22_4555 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AW22_4556 ENOG4108JJB ABC transporter AW22_456 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AW22_4562 ENOG41067V7 50S ribosomal protein L36 AW22_4564 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AW22_4566 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AW22_4571 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AW22_458 ENOG4108JUB Transcriptional regulator AW22_4592 ENOG4105XPM ribosomal protein AW22_4595 ENOG4107Y49 methyltransferase AW22_460 ENOG4107RDP Dehydrogenase AW22_4600 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AW22_4602 ENOG4105QIV RNA polymerase AW22_4603 ENOG4105M0M Tetracycline resistance protein AW22_4604 ENOG4105C2N RNA methyltransferase TrmH family group 3 AW22_4607 ENOG4105D7W serine acetyltransferase AW22_4611 ENOG4105CTP PilT protein domain protein AW22_4613 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AW22_4616 ENOG4108Z0C Uvrb UvrC protein AW22_4636 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AW22_4638 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AW22_4639 ENOG4105KRF dihydroneopterin aldolase AW22_464 ENOG4105CPP Dehydrogenase, E1 component AW22_4640 ENOG4105EEI dihydropteroate synthase AW22_4641 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 AW22_4642 ENOG4105DDQ anthranilate synthase AW22_4643 ENOG4105CRQ synthase (Component I) AW22_4644 ENOG4105C6T cysteine synthase AW22_4647 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AW22_4648 ENOG4108UGV hypoxanthine phosphoribosyltransferase AW22_465 ENOG4105C7S Dehydrogenase AW22_4653 ENOG41060GV RNA binding s1 domain protein AW22_4656 ENOG4105VYY sporulation protein yabp AW22_4657 ENOG41082I2 s4 domain protein AW22_4658 ENOG4108IY2 MazG family AW22_4660 ENOG4108M14 stage v sporulation protein t AW22_4661 ENOG4108JA2 transcriptioN-repair coupling factor AW22_4663 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AW22_4664 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AW22_4667 ENOG4105KME endoribonuclease L-psp AW22_4668 ENOG4105DFT pur operon repressor AW22_467 ENOG4105E09 nadh pyrophosphatase AW22_4671 ENOG4105W42 Veg protein AW22_4672 ENOG4105XFA sporulation peptidase YabG AW22_4674 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) AW22_4675 ENOG4105F8V Hydrolase, tatD family AW22_4677 ENOG4105KRN Transcriptional regulator, abrb family AW22_4678 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AW22_468 ENOG4105G7B Protein of unknown function (DUF2992) AW22_4680 ENOG41060K3 Methyltransferase AW22_4682 ENOG4105MA4 psp1 domain protein AW22_4683 ENOG4105FA2 dna polymerase iii AW22_4685 ENOG4105CXN decarboxylase AW22_4693 ENOG41067KS pro-sigma K processing AW22_4697 ENOG4105C6E dna polymerase iii AW22_4698 ENOG4108Z6B deaminase AW22_4699 ENOG4105GTG Isochorismatase AW22_470 ENOG4108HW3 (ABC) transporter AW22_4701 ENOG4105ZMH deoxynucleoside kinase AW22_4708 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AW22_471 ENOG4105E5Q amino acid AbC transporter AW22_4716 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AW22_4719 ENOG410848D S4 domain protein YaaA AW22_472 ENOG4105CDA abc transporter atp-binding protein AW22_4720 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AW22_4724 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AW22_473 ENOG4108QEG Membrane AW22_4730 ENOG4107QJE Chromosome Partitioning Protein AW22_4731 ENOG4105FA0 parb-like partition protein AW22_4732 ENOG4108ZDA Sporulation protein YyaC AW22_4733 ENOG4105D8X mechanosensitive ion channel AW22_4734 ENOG4105VDK protein, conserved in bacteria AW22_4735 ENOG4105C3G gtp-binding protein AW22_4737 ENOG4108UUM single-stranded DNA-binding protein AW22_4739 ENOG4108XMW Membrane AW22_474 ENOG4108VZI ErfK ybiS ycfS ynhG family protein AW22_4740 ENOG4105BZR domain protein AW22_4742 ENOG4105CDU Replicative dna helicase AW22_4748 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW22_4749 ENOG4105BZU Histidine kinase AW22_4752 ENOG4105Q2H domain protein AW22_4753 ENOG4105C0H protease AW22_4757 ENOG4105DPN Oligoendopeptidase f AW22_476 ENOG4105D9U N-acetyltransferase AW22_4760 ENOG4105C1J atp-dependent rna helicase AW22_4762 ENOG4108UT2 hemolysin iii AW22_4763 ENOG4105CMR udp-glucose 4-epimerase AW22_4765 ENOG4105IW1 AmiS UreI transporter AW22_4767 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AW22_477 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AW22_4770 ENOG4107RGD Major Facilitator superfamily AW22_4771 ENOG4108HRK Histidine kinase AW22_4772 ENOG4105DY9 regulatoR AW22_4775 ENOG4106F5Q Membrane AW22_4776 ENOG4105E0X reductase AW22_4778 ENOG41067SE Tetr family transcriptional regulator AW22_4779 ENOG4105CKK Glycosyl transferase, family 2 AW22_478 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AW22_4783 ENOG4105C5H ABC transporter AW22_4784 ENOG4105JEU Glycosyl transferase, family 2 AW22_4786 ENOG4108S4H thioesterase Superfamily protein AW22_4788 ENOG4106YBV Methyl-accepting chemotaxis AW22_4789 ENOG4105EN6 Membrane AW22_4793 ENOG41079KZ Major Facilitator Superfamily AW22_4794 ENOG4105DY9 regulatoR AW22_4795 ENOG4105D22 carbon starvation protein AW22_4796 ENOG4105VCD cytoplasmic protein AW22_4797 ENOG4105BZU Histidine kinase AW22_4798 ENOG4105DWF phosphomethylpyrimidine kinase AW22_4799 ENOG4105BZU Histidine kinase AW22_4800 ENOG4105WH1 Two component transcriptional regulator luxr family AW22_4802 ENOG4108Y4K DNA-binding transcriptional activator AW22_4803 ENOG4105D7V transposase AW22_4808 ENOG4105D6E homoserine dehydrogenase AW22_4811 ENOG41090WU lipolytic protein G-D-S-L family AW22_4812 ENOG4105CJ1 ABC, transporter AW22_4813 ENOG4108TU7 Inherit from COG: (ABC) transporter AW22_4815 ENOG4105VCH membrane AW22_4816 ENOG410667J hydrolase AW22_4818 ENOG4107SVH Potassium channel protein AW22_482 ENOG4105EJQ L-serine dehydratase AW22_4822 ENOG4108VKI Cell wall hydrolase AW22_4825 ENOG4108IJ2 phosphate acetyltransferase AW22_4828 ENOG4108VCI transcription factor, rsfa family AW22_483 ENOG4105II7 pyrroline-5-carboxylate reductase AW22_4830 ENOG4105DQ5 transport system permease protein AW22_4831 ENOG4105EHG Permease protein AW22_4832 ENOG4105E0A ABC, transporter AW22_4833 ENOG4108MES Periplasmic binding protein AW22_4834 ENOG4105DCI Phosphohydrolase AW22_4835 ENOG41069HH 4-oxalocrotonate tautomerase AW22_4836 ENOG4108Z4T Peptidase M50 AW22_4837 ENOG4108XFG YwhD family AW22_4838 ENOG4105BZ4 penicillin-binding protein AW22_4839 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AW22_484 ENOG41069FQ Metallo-beta-lactamase superfamily AW22_4840 ENOG4107SWG transcriptional regulator MERR family AW22_4841 ENOG4105DXB Major Facilitator superfamily AW22_4843 ENOG4105CYW agmatinase AW22_4847 ENOG410684U Domain of unknown function (DUF1934) AW22_4849 ENOG4105EMN RNA polymerase sigma factor AW22_485 ENOG4108IXY short-chain dehydrogenase reductase AW22_4853 ENOG4105IIU Aminopeptidase AW22_4855 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) AW22_4856 ENOG4108M15 ABC transporter AW22_4857 ENOG4105KCT ABC transporter AW22_4858 ENOG4105BZU Histidine kinase AW22_4863 ENOG4105BZU Histidine kinase AW22_4866 ENOG4105DF6 Fe-S oxidoreductase AW22_4868 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AW22_4869 ENOG4105C1G acyl-Coa dehydrogenase AW22_4870 ENOG4105C1G acyl-Coa dehydrogenase AW22_4877 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AW22_4878 ENOG4105CBT Fructose-1,6-bisphosphatase AW22_4879 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AW22_488 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AW22_4882 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AW22_4883 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AW22_4884 ENOG4108ZXQ stage ii sporulation protein r AW22_4886 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AW22_4891 ENOG4107XC4 flavin reductase domain protein, FMN-binding AW22_4892 ENOG4108VGI doxx family AW22_4895 ENOG4108YZG isomerase AW22_4900 ENOG41062M3 atp synthase AW22_4901 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) AW22_4911 ENOG4105BZU Histidine kinase AW22_4912 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AW22_4914 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AW22_4915 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AW22_4920 ENOG4105D65 subunit l AW22_4921 ENOG4105C8S subunit m AW22_4922 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AW22_4923 ENOG4106778 Protein of unknown function (DUF1146) AW22_4927 ENOG4105DY9 regulatoR AW22_4930 ENOG4105FRN stage II sporulation protein AW22_4931 ENOG4105MT0 Sporulation transcriptional regulator spoiiid AW22_4934 ENOG4107YJ4 chain length determinant protein AW22_4935 ENOG4105HTX biosynthesis protein AW22_4936 ENOG4107YJ4 chain length determinant protein AW22_4937 ENOG4108RB3 Capsular polysaccharide biosynthesis protein AW22_4938 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AW22_4939 ENOG4105D3Q Sugar transferase AW22_4940 ENOG4105C30 Nad-dependent epimerase dehydratase AW22_4941 ENOG4105C0K Gdp-mannose 4,6-dehydratase AW22_4945 ENOG4105CPK Glycosyl transferase (Group 1 AW22_4946 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase AW22_4947 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family AW22_4948 ENOG4105CJT Mannose-1-phosphate guanylyltransferase AW22_4950 ENOG4105DG6 mannose-6-phosphate isomerase AW22_4951 ENOG4108KGH TRANSCRIPTIONal AW22_4953 ENOG4105CMR udp-glucose 4-epimerase AW22_4955 ENOG4105DM4 PTS System AW22_4956 ENOG4105DG6 mannose-6-phosphate isomerase AW22_4957 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW22_496 ENOG4105CGH 5'-nucleotidase AW22_4961 ENOG4105CXY transporter AW22_4965 ENOG4105C19 ABC transporter AW22_4966 ENOG4107RBB ABC transporter, permease AW22_4969 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW22_497 ENOG4105DFD Na H antiporter AW22_4975 ENOG4105C0D helicase AW22_4976 ENOG4105KBK Zinc finger, swim domain protein AW22_4981 ENOG41069ER domain protein AW22_4982 ENOG4105C94 Transporter AW22_4984 ENOG4107R8N Glycosyl transferase, family 2 AW22_4989 ENOG4105E0M Sulfatase AW22_499 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AW22_4991 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) AW22_4993 ENOG4105D7V transposase AW22_4994 ENOG4105DAA L-lactate AW22_50 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AW22_5001 ENOG4107RSM transcriptional regulator AW22_5002 ENOG4105ECB domain protein AW22_5006 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily AW22_5009 ENOG4105VZJ PTS System AW22_5011 ENOG4105VCP PTS System AW22_5015 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AW22_5017 ENOG4105CK1 PTS System AW22_5018 ENOG4105VCP PTS System AW22_5019 ENOG4105F8D glycoside hydrolase family 4 AW22_502 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AW22_5023 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AW22_5025 ENOG4105ESV Glycosyl transferase, family 4 AW22_5026 ENOG4105C6Y Udp-glucose 6-dehydrogenase AW22_5027 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AW22_5028 ENOG4108KGH TRANSCRIPTIONal AW22_5029 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AW22_503 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AW22_5031 ENOG4105KVH Transcriptional regulator AW22_5034 ENOG41081UC Inherit from COG: Competence protein AW22_5035 ENOG4105VEQ Cold shock protein AW22_5036 ENOG4105MS2 ribosomal subunit Interface protein AW22_5038 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AW22_5040 ENOG4105CAK Cell division ATP-binding protein ftsE AW22_5041 ENOG4105CRP Part of the ABC transporter FtsEX involved in AW22_5042 ENOG4105CN1 protease AW22_5044 ENOG4105BZ1 (ABC) transporter AW22_5046 ENOG4105C5H ABC transporter AW22_5047 ENOG4108WS4 fmn reductase AW22_5049 ENOG4105DUM transcriptional regulator, lysR family AW22_5050 ENOG4105HMI Membrane AW22_5055 ENOG4107TXC Transcriptional regulator AW22_5058 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AW22_5059 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AW22_5061 ENOG41086DT Membrane protein of unknown function AW22_5065 ENOG4108S4C acetyltransferase AW22_5067 ENOG4105C3M thioredoxin reductase AW22_5069 ENOG4108Z4K mutator MutT protein AW22_5071 ENOG4105CHW UPF0052 protein AW22_5073 ENOG4105KRI phosphocarrier protein (HPr AW22_5074 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AW22_5075 ENOG4105H67 Protein of unknown function (DUF421) AW22_5078 ENOG4105CZ3 stage V sporulation protein ad AW22_5079 ENOG41090VF Stage v sporulation protein ac AW22_508 ENOG4108R6K riboflavin synthase, subunit alpha AW22_5083 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW22_5089 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AW22_509 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AW22_5093 ENOG41067MG lrgb family AW22_5094 ENOG4105XZU Preprotein translocase, subunit SecG AW22_5096 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AW22_51 ENOG4105BZU Histidine kinase AW22_5101 ENOG4105CM4 permease protein AW22_5102 ENOG4108IPW abc transporter atp-binding protein AW22_5106 ENOG4108VY7 phosphate-starvation-inducible protein PsiE AW22_5107 ENOG4108MK9 spermidine N(1)-acetyltransferase AW22_5108 ENOG4105C5H ABC transporter AW22_5113 ENOG4105WMR Protein CrcB homolog AW22_5115 ENOG4105C8Q Methyl-accepting chemotaxis AW22_5117 ENOG4105D4A Cell wall formation (By similarity) AW22_5118 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AW22_5121 ENOG4105KVH Transcriptional regulator AW22_5122 ENOG4105F27 Major Facilitator AW22_5123 ENOG4105CV8 reductase AW22_5126 ENOG4108RYK Nad-dependent epimerase dehydratase AW22_5129 ENOG4105D9N nucleoside AW22_513 ENOG4108YM7 Gcn5-related n-acetyltransferase AW22_5130 ENOG4105D9N nucleoside AW22_5134 ENOG4108URH decarboxylase AW22_5137 ENOG4108RMU ferritin dps family protein AW22_5139 ENOG4105NCW Trka-c domain protein AW22_514 ENOG4105ETE Transcriptional regulator (LacI family AW22_5140 ENOG4107S91 Sodium hydrogen exchanger AW22_5144 ENOG4105D4Y metalloprotease AW22_5145 ENOG4105VG1 fes assembly suf system protein AW22_5146 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AW22_5147 ENOG4105C8Q Methyl-accepting chemotaxis AW22_5152 ENOG4105BZU Histidine kinase AW22_5153 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW22_5154 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AW22_5156 ENOG4107ZTW SNARE associated Golgi AW22_516 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AW22_5164 ENOG4107AYK membrAne AW22_5166 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AW22_5169 ENOG4107R7I amino acid AW22_5170 ENOG4108SUT Major Facilitator Superfamily AW22_5174 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AW22_5178 ENOG4105DZ1 carboxypeptidase AW22_5181 ENOG4105CHU acetyl-coa acetyltransferase AW22_5182 ENOG4105C1G acyl-Coa dehydrogenase AW22_5187 ENOG4108IUW ABC transporter AW22_5190 ENOG4108W8B Beta-lactamase domain protein AW22_5196 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AW22_52 ENOG4105C2M dna polymerase I AW22_520 ENOG4105RHY Pfam:UPF0157 AW22_5205 ENOG41080E8 Transcriptional regulator, Spx MgsR family AW22_5211 ENOG4108UMI ABC transporter, permease AW22_5212 ENOG4105D01 (LipO)protein AW22_5213 ENOG4105D01 (LipO)protein AW22_5214 ENOG4105C3K feS assembly ATPase SufC AW22_5215 ENOG4105JRK feS assembly protein SufD AW22_5216 ENOG4105C9B Cysteine desulfurase AW22_5217 ENOG4108UNV SUF system FeS assembly protein, NifU family AW22_5218 ENOG4105DIW FeS assembly protein SUFB AW22_522 ENOG4105CPC Aldo Keto reductase AW22_5221 ENOG4107R8B 5'-nucleotidase AW22_5222 ENOG4105KZD Domain of unknown function (DUF1805) AW22_5224 ENOG4105FAA peptidase M23 AW22_5229 ENOG41090T1 Membrane AW22_5230 ENOG4107TXC Transcriptional regulator AW22_5231 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) AW22_5232 ENOG4105MMD transcriptional regulator AW22_5235 ENOG4105CBT Fructose-1,6-bisphosphatase AW22_5238 ENOG4105D4U had-superfamily hydrolase, subfamily iia AW22_5239 ENOG4105DYS nad(p)h dehydrogenase (quinone) AW22_5240 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AW22_5243 ENOG4108W5N phosphatidylglycerophosphatase a AW22_5246 ENOG41083MR nifu domain-containing protein AW22_5251 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AW22_5252 ENOG4105C4B ABC transporter, permease AW22_5253 ENOG4108JJA ABC, transporter AW22_5257 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AW22_526 ENOG4105MZ9 stage II sporulation protein m AW22_5260 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AW22_527 ENOG4105I3K Ferric uptake regulator, Fur family AW22_529 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AW22_53 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AW22_5306 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AW22_5311 ENOG4105EWC Purine nucleoside phosphorylase AW22_5317 ENOG4105CEP NADH dehydrogenase AW22_5320 ENOG41069ER domain protein AW22_5324 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AW22_5327 ENOG4105KA0 thioesterase Superfamily protein AW22_5328 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) AW22_5331 ENOG4107R3E Citrate transporter AW22_5333 ENOG4105Y38 Kinase-associated protein B AW22_5336 ENOG4105C87 Aminotransferase class I and II AW22_5338 ENOG4108MUZ hydrolase AW22_5339 ENOG4105C5I Dehydrogenase AW22_534 ENOG4105D7N magnesium and cobalt transport protein CorA AW22_5340 ENOG4108ZB6 transcriptional regulator AsnC family AW22_5341 ENOG4105CHM Aminotransferase AW22_5343 ENOG4105WG9 Conserved Protein AW22_5345 ENOG4107PBV potassium channel AW22_5347 ENOG4105KT7 mgtC SapB transporter AW22_5355 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AW22_5374 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AW22_5375 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AW22_5385 ENOG4105VEQ Cold shock protein AW22_5387 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AW22_5388 ENOG4105E4F Isochorismate synthase AW22_5390 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) AW22_5391 ENOG4108IPT Naphthoate synthase AW22_5393 ENOG4105DTQ mandelate racemase muconate lactonizing AW22_5397 ENOG41069H0 dihydroorotase EC 3.5.2.3 AW22_540 ENOG4105DVE abc transporter atp-binding protein AW22_5401 ENOG4105FDP GntR family transcriptional regulator AW22_5402 ENOG4105C6Z Gluconate AW22_541 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AW22_5410 ENOG41086D8 Transcriptional regulator AW22_5411 ENOG4105C19 ABC transporter AW22_5414 ENOG4107ZTW SNARE associated Golgi AW22_5418 ENOG4105D7V transposase AW22_5419 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) AW22_542 ENOG4105DZ1 carboxypeptidase AW22_5420 ENOG4108UGV hypoxanthine phosphoribosyltransferase AW22_5425 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW22_5426 ENOG4105BZU Histidine kinase AW22_5427 ENOG4105N67 Proton-coupled thiamine transporter YuaJ AW22_543 ENOG41082AN stage II sporulation protein AW22_5435 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin AW22_5441 ENOG41087YS Phage shock protein A AW22_545 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW22_5450 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AW22_5451 ENOG4105C4M (Ubiquinol oxidase) subunit I AW22_5453 ENOG4108V2W Carbonate dehydratase AW22_546 ENOG4105C8J )-transporter AW22_5460 ENOG4107XGZ Hydrolase AW22_5463 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component AW22_5465 ENOG4105D2X ABC transporter substrate-binding protein AW22_5468 ENOG4107T7U Sulfatase AW22_5469 ENOG4107S9D Alpha beta hydrolase AW22_5470 ENOG4105BZU Histidine kinase AW22_5471 ENOG4105BZU Histidine kinase AW22_5473 ENOG4105E98 transcriptional regulator DeoR family AW22_5474 ENOG4107XGZ Hydrolase AW22_5486 ENOG4108RIR Molybdenum cofactor biosynthesis protein AW22_5488 ENOG4105BZF Glycosyl transferase (Group 1 AW22_5489 ENOG4105YVM Phosphoesterase, PA-phosphatase related AW22_5490 ENOG4108Z0R Transferase AW22_5491 ENOG4105E8V Alpha Beta Hydrolase Fold protein AW22_55 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AW22_550 ENOG41090VF Stage v sporulation protein ac AW22_5500 ENOG4105CIG ABC transporter AW22_5502 ENOG4105N5T Radical SAM Protein AW22_5506 ENOG4105C19 ABC transporter AW22_551 ENOG4105CZ3 stage V sporulation protein ad AW22_5510 ENOG4105NCW Trka-c domain protein AW22_5511 ENOG4107S91 Sodium hydrogen exchanger AW22_5512 ENOG410605W Major Facilitator AW22_5518 ENOG4108B31 Spore germination protein AW22_5520 ENOG4105DWV Homoserine O-trans-acetylase AW22_5522 ENOG41085GJ domain protein AW22_5526 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AW22_5527 ENOG4105D06 uba thif-type nad fad binding protein AW22_5529 ENOG4105CVM Molybdenum cofactor synthesis domain protein AW22_553 ENOG4105G6R Stage v sporulation protein ae AW22_5530 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein AW22_5531 ENOG4108ZAF Molybdopterin AW22_5535 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AW22_5536 ENOG4108VJ1 Transcriptional regulator (CarD family AW22_5543 ENOG4105CBX hi0933 family AW22_5546 ENOG4105YW5 deoR family transcriptional regulator AW22_5547 ENOG4107QSE Dipeptidase AW22_5549 ENOG4108IUM Glycogen debranching enzyme AW22_555 ENOG4105J7I hydrolase AW22_5550 ENOG4108V15 phosphotransferase enzyme family AW22_5553 ENOG4105C8F Beta-lactamase domain protein AW22_5559 ENOG4108VDD TRNA binding domain protein AW22_556 ENOG4105PTM secreted protein AW22_5565 ENOG4105K7K Transcriptional regulator AW22_557 ENOG4107ZE5 PPIases accelerate the folding of proteins AW22_5573 ENOG4105C88 aminopeptidase AW22_5577 ENOG4105ETE Transcriptional regulator (LacI family AW22_5583 ENOG4105EP9 oxidoreductase AW22_5584 ENOG4107SNB ankyrin repeat protein YahD AW22_5585 ENOG4105BZU Histidine kinase AW22_5586 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW22_5589 ENOG4105DGU Histone deacetylase AW22_5590 ENOG4105W87 Cbs domain AW22_5591 ENOG4105F1V Acetoin utilization protein AW22_5594 ENOG4105EMN RNA polymerase sigma factor AW22_56 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AW22_5600 ENOG4105C28 cystathionine AW22_5602 ENOG4105U5Y Transcriptional regulator AW22_5603 ENOG4105U5Y Transcriptional regulator AW22_5605 ENOG4106KR7 LysR family Transcriptional regulator AW22_5610 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AW22_5612 ENOG4105EFZ amidohydrolase AW22_5615 ENOG4105KBJ sporulation protein ytfj AW22_5616 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AW22_5618 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AW22_5622 ENOG4105C3M thioredoxin reductase AW22_564 ENOG4105CE4 GlcNAc 6-P deacetylase AW22_5659 ENOG41086D8 Transcriptional regulator AW22_566 ENOG4105FDP GntR family transcriptional regulator AW22_5665 ENOG4105DHF Membrane AW22_5671 ENOG4105K70 DNA-binding protein AW22_568 ENOG4105CID antiterminator AW22_5682 ENOG4105KRN Transcriptional regulator, abrb family AW22_5685 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AW22_5694 ENOG4108J59 Extracellular solute-binding protein, family 5 AW22_5697 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AW22_57 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AW22_571 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AW22_5713 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) AW22_5724 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AW22_5732 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AW22_575 ENOG4106TD9 Diguanylate cyclase AW22_576 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AW22_5767 ENOG4105EKQ RNA-directed DNA polymerase AW22_5779 ENOG4105EKQ RNA-directed DNA polymerase AW22_5790 ENOG4105EKQ RNA-directed DNA polymerase AW22_5791 ENOG4107QZI cell division protein FtsK AW22_5797 ENOG4105D7V transposase AW22_5825 ENOG41085FC arsR family transcriptional regulator AW22_5826 ENOG4105CAY ferredoxin--nadp reductase AW22_5827 ENOG4105H3G oxidoreductase AW22_5829 ENOG4105CN5 Metallo-Beta-Lactamase AW22_5830 ENOG4107YZX Universal stress protein AW22_5831 ENOG4105CHH sulfate transporter AW22_5835 ENOG4105CHH sulfate transporter AW22_5838 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AW22_584 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AW22_5845 ENOG41082YX Transcriptional regulator, arsr family AW22_5846 ENOG4105D6J arsenicaL-resistance protein AW22_588 ENOG4105DTD Dehydrogenase AW22_589 ENOG4105K7K Transcriptional regulator AW22_595 ENOG4105CHU acetyl-coa acetyltransferase AW22_604 ENOG4105CG3 alpha amylase, catalytic region AW22_606 ENOG4107FKK extracellular solute-binding protein family 1 AW22_608 ENOG4105EG2 ABC transporter, permease AW22_609 ENOG4105FKQ transcriptional regulator AW22_61 ENOG4108TDW sporulation protein YtxC AW22_610 ENOG4105CHM Aminotransferase AW22_612 ENOG4108HGU Histidine kinase AW22_62 ENOG4105C22 threonyL-tRNA synthetase AW22_623 ENOG4105UIN AW22_625 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AW22_628 ENOG4105K6S Short-chain dehydrogenase reductase Sdr AW22_629 ENOG4105EPM Diguanylate phosphodiesterase AW22_63 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AW22_632 ENOG4107IN1 Protein of unknown function (DUF1797) AW22_634 ENOG4108XRC Protein of unknown function (DUF458) AW22_641 ENOG4107ZYR domain protein AW22_642 ENOG4105CN5 Metallo-Beta-Lactamase AW22_644 ENOG4108X4Q Hydrolase AW22_645 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AW22_648 ENOG4105CPP Dehydrogenase, E1 component AW22_657 ENOG4105CXN decarboxylase AW22_661 ENOG4105ECY inositol monophosphatase AW22_663 ENOG4105CI3 gtp-binding protein typa AW22_664 ENOG4105QA2 AW22_668 ENOG4108IAB Phoh family AW22_67 ENOG4105CN9 Peptidase m42 family protein AW22_671 ENOG4105CNI cell division protein FtsW AW22_672 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) AW22_68 ENOG4108JGH Tetr family transcriptional regulator AW22_682 ENOG4106UY4 Inherit from COG: Scp-like extracellular AW22_685 ENOG4107TB6 phosphoglycerate mutase AW22_689 ENOG4106H78 methyltransferase AW22_69 ENOG4105CW7 secretion protein, HlyD family AW22_690 ENOG4105H20 Sporulation integral membrane protein YlbJ AW22_692 ENOG4105D78 K07001 NTE family protein AW22_693 ENOG41063PX domain protein AW22_695 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) AW22_70 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW22_702 ENOG4108IMY Transcriptional regulator AW22_732 ENOG4105CAR Terminase, large subunit AW22_735 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AW22_749 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AW22_751 ENOG41086D8 Transcriptional regulator AW22_757 ENOG4105KNH Nucleic acid-binding protein AW22_764 ENOG41068DC Essential cell division protein (By similarity) AW22_765 ENOG4105CJN penicillin-binding protein AW22_766 ENOG4105CJN penicillin-binding protein AW22_767 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AW22_770 ENOG4105CNI cell division protein FtsW AW22_771 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AW22_772 ENOG4105D4A Cell wall formation (By similarity) AW22_773 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) AW22_774 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AW22_775 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AW22_777 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW22_779 ENOG4105WR5 sporulation protein, YlmC YmxH family AW22_780 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AW22_781 ENOG4105DFA alanine racemase domain protein AW22_783 ENOG41067XK integral membrane protein AW22_784 ENOG4105DBK s4 domain protein AW22_789 ENOG4105C34 Pseudouridine synthase AW22_79 ENOG4108RWN rrna methyltransferase AW22_794 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AW22_805 ENOG4105DC7 peptidase M24 AW22_806 ENOG4105F23 Fibronectin-binding protein AW22_807 ENOG4105F23 Fibronectin-binding protein AW22_809 ENOG4105DSJ YicC domain protein AW22_81 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AW22_813 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AW22_814 ENOG4105C25 Primosomal protein n' AW22_815 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AW22_817 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AW22_819 ENOG4108ZF3 Phosphatase AW22_82 ENOG4105C5S asparaginyl-tRNA synthetase AW22_820 ENOG4105D9P serine threonine protein kinase AW22_821 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AW22_822 ENOG4105DJV ribulose-phosphate 3-epimerase AW22_823 ENOG4105FJ0 thiamine AW22_825 ENOG4108ZAA Alkaline-shock protein AW22_826 ENOG4105DP4 dak2 domain fusion protein ylov AW22_827 ENOG4105CB5 ATP-dependent DNA helicase recG AW22_830 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AW22_831 ENOG4105CHR reductase AW22_834 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AW22_835 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AW22_839 ENOG4105VB6 UPF0109 protein AW22_844 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AW22_847 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AW22_848 ENOG4105C79 DNA protecting protein DprA AW22_849 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AW22_851 ENOG4108HE4 integrase family AW22_860 ENOG4105KNE Phosphatidate cytidylyltransferase AW22_861 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AW22_862 ENOG4105DZP Membrane-associated zinc metalloprotease AW22_864 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AW22_866 ENOG4105EKQ RNA-directed DNA polymerase AW22_867 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AW22_869 ENOG4105CHV Transcription elongation factor NusA AW22_870 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination AW22_871 ENOG4105VHM ribosomal protein AW22_873 ENOG4105W7A Protein of unknown function (DUF503) AW22_876 ENOG4105DTN riboflavin biosynthesis protein ribF AW22_880 ENOG4105C1V Peptidase, M16 AW22_882 ENOG4105E35 Dipicolinate synthase subunit A AW22_883 ENOG4108S0H Dipicolinic acid synthetase, b subunit AW22_884 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AW22_886 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AW22_888 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit AW22_89 ENOG4105DCG PHP domain protein AW22_890 ENOG4107QZI cell division protein FtsK AW22_891 ENOG4105FDP GntR family transcriptional regulator AW22_892 ENOG4105DIH basic membrane AW22_893 ENOG4108JQ9 ABC transporter AW22_894 ENOG4105UIB (ABC) transporter AW22_898 ENOG4108RKS Short-chain dehydrogenase reductase Sdr AW22_899 ENOG4105XZV Protein of unknown function (DUF3243) AW22_9 ENOG4107YZX Universal stress protein AW22_902 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AW22_907 ENOG4105D48 metallophosphoesterase AW22_908 ENOG4105MCT stage V sporulation protein S AW22_909 ENOG4108IGT Dipeptidase AW22_910 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein AW22_911 ENOG4105DQU oxidoreductase, subunit beta AW22_917 ENOG4107QHE Choloylglycine hydrolase AW22_919 ENOG410890F Dynamin family AW22_92 ENOG4105FE9 pseudouridine synthase AW22_920 ENOG4105E0M Sulfatase AW22_922 ENOG4105F0V Cell wall hydrolase AW22_936 ENOG4105BZU Histidine kinase AW22_937 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase AW22_94 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) AW22_943 ENOG4105D03 DNA-3-methyladenine glycosylase II AW22_944 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AW22_946 ENOG4105CGK Exodeoxyribonuclease III AW22_95 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) AW22_950 ENOG4105E0A ABC, transporter AW22_951 ENOG4105NIV Esterase AW22_954 ENOG4105VPX protein, conserved in bacteria AW22_955 ENOG410681U heavy metal transport detoxification protein AW22_956 ENOG4105C59 p-type ATPase AW22_957 ENOG4105K70 DNA-binding protein AW22_958 ENOG4105TMB Formate nitrite transporter AW22_962 ENOG4105C85 amino acid AW22_965 ENOG4108SJC Membrane AW22_966 ENOG4107QW4 alcohol dehydrogenase AW22_967 ENOG4105E98 transcriptional regulator DeoR family AW22_968 ENOG4105DE4 1-phosphofructokinase AW22_969 ENOG4105DM4 PTS System AW22_970 ENOG41069ER domain protein AW22_976 ENOG4106F1P AAA ATPase, central domain protein AW22_978 ENOG4105EN6 Membrane AW22_979 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AW22_98 ENOG4105E0A ABC, transporter AW22_980 ENOG4105CXI aluminum resistance protein AW22_981 ENOG4105KV4 Transcriptional regulator AW22_982 ENOG4105C5F glutamine synthetase AW22_983 ENOG4105K7K Transcriptional regulator AW22_987 ENOG4108SVB resolvase AW22_989 ENOG4105CGH 5'-nucleotidase AW22_99 ENOG4105KFN sortase, SrtB family AW22_997 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)