locus-tag	class	description
AW22_10	COG1028	Short-chain dehydrogenase reductase Sdr
AW22_1011	COG4932	domain protein
AW22_1011	COG4886	Leucine-rich repeat (LRR) protein
AW22_1014	COG1132	(ABC) transporter
AW22_1015	COG1132	(ABC) transporter
AW22_1018	COG3409	Peptidoglycan-binding domain 1 protein
AW22_1018	COG5632	N-Acetylmuramoyl-L-alanine amidase
AW22_102	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AW22_1020	COG0730	response to heat
AW22_1023	COG1346	cytolysis
AW22_1025	COG0583	DNA-binding transcription factor activity
AW22_1027	COG1131	(ABC) transporter
AW22_103	COG4895	conserved protein (DUF2196)
AW22_1031	COG0785	Cytochrome C biogenesis protein
AW22_1032	COG4846	Membrane protein involved in cytochrome C biogenesis
AW22_1034	COG3344	reverse transcriptase
AW22_1042	COG2226	methyltransferase
AW22_1047	COG0010	Belongs to the arginase family
AW22_1048	COG1329	Transcriptional regulator
AW22_1049	COG1902	pentaerythritol trinitrate reductase activity
AW22_105	COG0745	RESPONSE REGULATOR receiver
AW22_1050	COG0069	glutamate synthase activity
AW22_1051	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AW22_1052	COG0346	lactoylglutathione lyase activity
AW22_1053	COG0400	carboxylic ester hydrolase activity
AW22_1054	COG5002	protein histidine kinase activity
AW22_1056	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AW22_106	COG2205	protein histidine kinase activity
AW22_1066	COG1396	sequence-specific DNA binding
AW22_1068	COG0318	PFAM AMP-dependent synthetase and ligase
AW22_1069	COG1268	BioY protein
AW22_107	COG1131	(ABC) transporter
AW22_1070	COG0318	PFAM AMP-dependent synthetase and ligase
AW22_1071	COG0183	Belongs to the thiolase family
AW22_1074	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AW22_1076	COG2211	Major facilitator Superfamily
AW22_1080	COG0726	polysaccharide deacetylase
AW22_1082	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AW22_1083	COG2274	protein secretion by the type I secretion system
AW22_1085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AW22_1091	COG0824	Thioesterase
AW22_1092	COG4841	protein insertion into membrane
AW22_1096	COG0745	RESPONSE REGULATOR receiver
AW22_1097	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AW22_1098	COG1832	CoA-binding protein
AW22_1099	COG0187	DNA topoisomerase II activity
AW22_1100	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AW22_1101	COG0673	inositol 2-dehydrogenase activity
AW22_1103	COG1131	(ABC) transporter
AW22_1107	COG1595	DNA-templated transcription, initiation
AW22_1110	COG1316	TRANSCRIPTIONal
AW22_1111	COG1301	dicarboxylic acid transport
AW22_1112	COG4166	transmembrane transport
AW22_1113	COG4166	transmembrane transport
AW22_1116	COG4166	transmembrane transport
AW22_1117	COG2226	methyltransferase
AW22_112	COG2318	DinB family
AW22_1125	COG0697	spore germination
AW22_1127	COG3383	formate dehydrogenase (NAD+) activity
AW22_1128	COG2427	Protein of unknown function (DUF1641)
AW22_1129	COG5609	conserved protein (DUF2294)
AW22_1130	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AW22_1132	COG2116	formate transmembrane transporter activity
AW22_1133	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AW22_1134	COG0303	'Molybdopterin
AW22_1135	COG0314	molybdopterin synthase activity
AW22_1137	COG0489	protein tyrosine kinase activity
AW22_1140	COG3326	Membrane
AW22_1141	COG2962	Rard protein
AW22_1142	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AW22_1143	COG1657	PFAM Prenyltransferase squalene oxidase
AW22_1145	COG1028	Short-chain dehydrogenase reductase Sdr
AW22_1146	COG1012	belongs to the aldehyde dehydrogenase family
AW22_1148	COG4145	pantothenate transmembrane transporter activity
AW22_1151	COG0165	Argininosuccinate lyase
AW22_1153	COG1028	Short-chain dehydrogenase reductase Sdr
AW22_116	COG0318	PFAM AMP-dependent synthetase and ligase
AW22_1160	COG0716	FMN binding
AW22_1162	COG1278	Cold shock
AW22_1167	COG2720	vancomycin resistance protein
AW22_1168	COG2514	catechol 2,3-dioxygenase activity
AW22_117	COG1309	transcriptional regulator
AW22_1170	COG1285	pathogenesis
AW22_1172	COG1024	Enoyl-CoA hydratase
AW22_1173	COG1216	Glycosyl transferase, family 2
AW22_1179	COG0277	FAD linked oxidase domain protein
AW22_118	COG1024	Enoyl-CoA hydratase
AW22_1180	COG0385	Bile acid
AW22_1184	COG2808	Putative FMN-binding domain
AW22_1186	COG0457	Tetratricopeptide repeat
AW22_1188	COG0604	alcohol dehydrogenase
AW22_1189	COG0640	Transcriptional regulator
AW22_119	COG2086	electron transfer activity
AW22_1194	COG0584	glycerophosphoryl diester phosphodiesterase
AW22_120	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AW22_1200	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AW22_1201	COG1164	Oligoendopeptidase f
AW22_1202	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AW22_1206	COG1193	negative regulation of DNA recombination
AW22_121	COG3118	belongs to the thioredoxin family
AW22_1210	COG0583	DNA-binding transcription factor activity
AW22_1214	COG0384	phenazine biosynthesis protein PhzF
AW22_1215	COG3739	integral membrane protein
AW22_1216	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AW22_1217	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AW22_1218	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AW22_1221	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AW22_1222	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AW22_1227	COG2814	Major facilitator Superfamily
AW22_1228	COG1113	amino acid transport
AW22_123	COG1719	4-vinyl reductase, 4VR
AW22_1237	COG2072	flavoprotein involved in K transport
AW22_124	COG2009	succinate dehydrogenase
AW22_1244	COG3409	Peptidoglycan-binding domain 1 protein
AW22_1244	COG3757	hydrolase, family 25
AW22_1245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AW22_1247	COG1151	hydroxylamine reductase activity
AW22_125	COG1053	succinate dehydrogenase
AW22_1255	COG1309	transcriptional regulator
AW22_1256	COG1266	CAAX protease self-immunity
AW22_1257	COG1191	sigma factor activity
AW22_1259	COG0726	polysaccharide deacetylase
AW22_126	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AW22_1261	COG1733	regulation of RNA biosynthetic process
AW22_1262	COG2249	NAD(P)H dehydrogenase (quinone) activity
AW22_1263	COG0318	PFAM AMP-dependent synthetase and ligase
AW22_1266	COG0384	phenazine biosynthesis protein PhzF
AW22_127	COG0824	Thioesterase
AW22_1274	COG0673	inositol 2-dehydrogenase activity
AW22_1275	COG2188	Transcriptional regulator
AW22_1276	COG1393	Belongs to the ArsC family
AW22_128	COG1876	peptidase activity
AW22_1281	COG0814	amino acid
AW22_1287	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AW22_1289	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AW22_129	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AW22_1290	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AW22_1292	COG1070	Carbohydrate kinase
AW22_1293	COG2706	6-phosphogluconolactonase activity
AW22_1294	COG3813	Protein conserved in bacteria
AW22_1295	COG1357	PFAM Pentapeptide repeats (8 copies)
AW22_1296	COG0697	spore germination
AW22_1297	COG0789	Transcriptional regulator
AW22_1298	COG1253	flavin adenine dinucleotide binding
AW22_13	COG1476	TRANSCRIPTIONal
AW22_130	COG1360	Flagellar Motor Protein
AW22_1304	COG0477	Major facilitator Superfamily
AW22_1306	COG2226	methyltransferase
AW22_131	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AW22_1310	COG0628	permease
AW22_1312	COG0180	Tryptophanyl-tRNA synthetase
AW22_1314	COG0577	efflux transmembrane transporter activity
AW22_1314	COG1136	(ABC) transporter
AW22_1317	COG0110	maltose O-acetyltransferase activity
AW22_1318	COG1940	carbohydrate kinase activity
AW22_1319	COG0346	lactoylglutathione lyase activity
AW22_132	COG4152	abc transporter atp-binding protein
AW22_1328	COG1011	Hydrolase
AW22_133	COG1668	transmembrane transport
AW22_1336	COG1131	(ABC) transporter
AW22_1338	COG1028	Short-chain dehydrogenase reductase Sdr
AW22_134	COG1959	2 iron, 2 sulfur cluster binding
AW22_1342	COG0469	pyruvate kinase activity
AW22_1344	COG0778	Nitroreductase
AW22_1345	COG1733	regulation of RNA biosynthetic process
AW22_1349	COG2197	response regulator
AW22_1351	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AW22_1352	COG2356	endonuclease I
AW22_1353	COG1288	antiporter activity
AW22_1357	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AW22_136	COG0697	spore germination
AW22_1364	COG2249	NAD(P)H dehydrogenase (quinone) activity
AW22_1366	COG2031	fatty acid transporter
AW22_1369	COG1309	transcriptional regulator
AW22_137	COG1396	sequence-specific DNA binding
AW22_1370	COG2076	Multidrug Resistance protein
AW22_1374	COG1131	(ABC) transporter
AW22_1375	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AW22_1378	COG2814	Major facilitator Superfamily
AW22_1379	COG1846	Transcriptional regulator
AW22_1381	COG0477	Major facilitator Superfamily
AW22_139	COG0402	S-adenosylhomocysteine deaminase activity
AW22_1390	COG2814	Major facilitator Superfamily
AW22_1393	COG3409	Peptidoglycan-binding domain 1 protein
AW22_1393	COG5632	N-Acetylmuramoyl-L-alanine amidase
AW22_1399	COG2207	Transcriptional regulator
AW22_1399	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AW22_140	COG2233	PERMEase
AW22_1400	COG0662	Cupin 2, conserved barrel domain protein
AW22_1403	COG1595	DNA-templated transcription, initiation
AW22_1407	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AW22_141	COG2197	response regulator
AW22_1410	COG1619	proteins homologs of microcin C7 resistance protein MccF
AW22_1414	COG0583	DNA-binding transcription factor activity
AW22_1416	COG1139	Iron-sulfur cluster binding protein
AW22_1417	COG1556	Lactate utilization protein
AW22_1418	COG2271	Major facilitator Superfamily
AW22_1419	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AW22_1420	COG2808	Putative FMN-binding domain
AW22_1421	COG0456	acetyltransferase
AW22_1422	COG1846	Transcriptional regulator
AW22_1423	COG2364	Membrane
AW22_1425	COG5002	protein histidine kinase activity
AW22_1425	COG3850	Histidine kinase
AW22_1428	COG0577	efflux transmembrane transporter activity
AW22_1432	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AW22_1433	COG0789	Transcriptional regulator
AW22_1435	COG2309	aminopeptidase activity
AW22_1438	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AW22_144	COG1309	transcriptional regulator
AW22_1440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AW22_1441	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AW22_1446	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AW22_1451	COG5002	protein histidine kinase activity
AW22_1451	COG3850	Histidine kinase
AW22_1452	COG0745	RESPONSE REGULATOR receiver
AW22_1457	COG2814	Major facilitator Superfamily
AW22_1465	COG0346	lactoylglutathione lyase activity
AW22_1469	COG0443	Heat shock 70 kDa protein
AW22_1473	COG0640	Transcriptional regulator
AW22_1474	COG0346	lactoylglutathione lyase activity
AW22_1475	COG0798	PFAM Bile acid sodium symporter
AW22_148	COG5401	PFAM Sporulation and spore germination
AW22_1481	COG1121	(ABC) transporter
AW22_1482	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AW22_1483	COG0803	Belongs to the bacterial solute-binding protein 9 family
AW22_1484	COG2267	carboxylic ester hydrolase activity
AW22_1485	COG1575	Belongs to the MenA family. Type 1 subfamily
AW22_1486	COG0714	Associated with various cellular activities
AW22_1489	COG5609	conserved protein (DUF2294)
AW22_1490	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AW22_1492	COG0288	reversible hydration of carbon dioxide
AW22_1495	COG0415	Belongs to the DNA photolyase family
AW22_1496	COG0415	Belongs to the DNA photolyase family
AW22_15	COG0662	Cupin 2, conserved barrel domain protein
AW22_150	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AW22_1501	COG1309	transcriptional regulator
AW22_1502	COG2124	cytochrome p450
AW22_1504	COG1063	alcohol dehydrogenase
AW22_1509	COG0598	Magnesium transport protein CorA
AW22_151	COG0622	Phosphoesterase
AW22_1511	COG2329	Antibiotic biosynthesis monooxygenase
AW22_1512	COG0737	Belongs to the 5'-nucleotidase family
AW22_1515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AW22_1518	COG1063	alcohol dehydrogenase
AW22_1524	COG1113	amino acid transport
AW22_1525	COG1280	lysine exporter protein (LysE YggA)
AW22_1526	COG3403	YqcI/YcgG family
AW22_1528	COG5577	PFAM Coat F domain
AW22_1531	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AW22_1533	COG3848	Pyruvate phosphate dikinase
AW22_1533	COG0574	Belongs to the PEP-utilizing enzyme family
AW22_1542	COG1960	acyl-CoA dehydrogenase activity
AW22_1544	COG0640	Transcriptional regulator
AW22_1545	COG0860	N-Acetylmuramoyl-L-alanine amidase
AW22_1546	COG3142	Participates in the control of copper homeostasis
AW22_1548	COG1414	Transcriptional regulator
AW22_1549	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AW22_1550	COG1984	allophanate hydrolase subunit 2
AW22_1556	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AW22_1565	COG4335	DNA alkylation repair
AW22_1567	COG0833	amino acid
AW22_1569	COG0730	response to heat
AW22_1575	COG0596	Alpha beta hydrolase
AW22_1576	COG0745	RESPONSE REGULATOR receiver
AW22_1577	COG0642	Histidine kinase
AW22_1582	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AW22_1586	COG0456	acetyltransferase
AW22_1587	COG2207	Transcriptional regulator
AW22_1592	COG1136	(ABC) transporter
AW22_1592	COG0577	efflux transmembrane transporter activity
AW22_1595	COG1725	Transcriptional regulator
AW22_160	COG1067	ATP-dependent peptidase activity
AW22_160	COG0470	DNA polymerase III
AW22_1602	COG1846	Transcriptional regulator
AW22_1603	COG0778	Nitroreductase
AW22_1610	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AW22_1612	COG0753	catalase activity
AW22_1613	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AW22_1615	COG0463	Glycosyl transferase, family 2
AW22_1624	COG0714	Associated with various cellular activities
AW22_1629	COG0346	lactoylglutathione lyase activity
AW22_163	COG1764	response to oxidative stress
AW22_1630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AW22_1635	COG3279	Response regulator of the LytR AlgR family
AW22_1637	COG4377	Putative membrane peptidase family (DUF2324)
AW22_164	COG1846	Transcriptional regulator
AW22_1640	COG3655	Transcriptional regulator
AW22_1642	COG1785	Belongs to the alkaline phosphatase family
AW22_1643	COG3239	Fatty acid desaturase
AW22_1644	COG1690	Belongs to the RtcB family
AW22_1645	COG0833	amino acid
AW22_1646	COG1414	Transcriptional regulator
AW22_1647	COG4187	Peptidase family M20/M25/M40
AW22_1648	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AW22_1649	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AW22_1651	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AW22_1655	COG2329	Antibiotic biosynthesis monooxygenase
AW22_166	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AW22_1662	COG1070	Carbohydrate kinase
AW22_1663	COG2390	Transcriptional regulator
AW22_1665	COG1172	Belongs to the binding-protein-dependent transport system permease family
AW22_1667	COG1879	ABC-type sugar transport system periplasmic component
AW22_1670	COG3290	protein histidine kinase activity
AW22_1670	COG3829	transcription factor binding
AW22_1672	COG1024	Enoyl-CoA hydratase
AW22_1673	COG2610	gluconate transmembrane transporter activity
AW22_1675	COG1388	LysM domain
AW22_1675	COG3584	3D domain protein
AW22_168	COG1587	Uroporphyrinogen-III synthase
AW22_1682	COG1605	Chorismate mutase
AW22_1682	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AW22_1684	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AW22_1685	COG0287	Prephenate dehydrogenase
AW22_1688	COG1309	transcriptional regulator
AW22_1689	COG2409	Drug exporters of the RND superfamily
AW22_1689	COG1033	growth of symbiont in host cell
AW22_169	COG0113	porphobilinogen synthase activity
AW22_1691	COG0488	(ABC) transporter
AW22_1692	COG1368	sulfuric ester hydrolase activity
AW22_1693	COG0861	Integral membrane protein TerC family
AW22_1701	COG2318	DinB family
AW22_1702	COG0697	spore germination
AW22_1708	COG2746	aminoglycoside 3-N-acetyltransferase activity
AW22_171	COG1388	LysM domain
AW22_1714	COG1116	anion transmembrane transporter activity
AW22_1715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AW22_1716	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AW22_1717	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AW22_1719	COG0628	permease
AW22_1727	COG1131	(ABC) transporter
AW22_173	COG0525	valine-tRNA ligase activity
AW22_1730	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AW22_1731	COG5146	pantothenate kinase activity
AW22_1732	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AW22_1733	COG0436	Aminotransferase
AW22_1739	COG2226	methyltransferase
AW22_174	COG0285	dihydrofolate synthase activity
AW22_1742	COG2261	transglycosylase associated protein
AW22_1746	COG0477	Major facilitator Superfamily
AW22_1746	COG2814	Major facilitator Superfamily
AW22_1747	COG4533	DNA binding
AW22_1748	COG0789	Transcriptional regulator
AW22_1749	COG1664	Polymer-forming cytoskeletal
AW22_1751	COG2814	Major facilitator Superfamily
AW22_1758	COG1307	EDD domain protein, DegV family
AW22_1759	COG1522	sequence-specific DNA binding
AW22_1760	COG0531	amino acid
AW22_1761	COG1164	Oligoendopeptidase f
AW22_1767	COG0745	RESPONSE REGULATOR receiver
AW22_1768	COG5002	protein histidine kinase activity
AW22_1769	COG2936	dipeptidyl-peptidase activity
AW22_1778	COG4948	Mandelate Racemase Muconate Lactonizing
AW22_178	COG1077	Cell shape determining protein MreB Mrl
AW22_1780	COG4166	transmembrane transport
AW22_1781	COG0519	Catalyzes the synthesis of GMP from XMP
AW22_1782	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AW22_1785	COG0586	Pfam SNARE associated Golgi protein
AW22_179	COG1792	Involved in formation and maintenance of cell shape
AW22_1793	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AW22_1794	COG3938	Belongs to the proline racemase family
AW22_1796	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AW22_1797	COG1012	belongs to the aldehyde dehydrogenase family
AW22_1798	COG1115	amino acid carrier protein
AW22_1799	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AW22_1801	COG3397	chitin binding
AW22_1806	COG4637	Psort location Cytoplasmic, score
AW22_1810	COG0514	ATP-dependent DNA helicase (RecQ)
AW22_1811	COG2105	PFAM AIG2 family protein
AW22_1814	COG3973	AAA domain
AW22_182	COG2894	cell division
AW22_1824	COG0658	competence protein
AW22_1824	COG2333	competence protein COMEC
AW22_1825	COG2153	protein acetylation
AW22_1826	COG2315	Protein conserved in bacteria
AW22_1827	COG2226	methyltransferase
AW22_1828	COG2205	protein histidine kinase activity
AW22_183	COG0739	heme binding
AW22_1830	COG3397	chitin binding
AW22_1831	COG2153	protein acetylation
AW22_1832	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AW22_1835	COG0740	serine-type endopeptidase activity
AW22_1837	COG4175	Glycine betaine
AW22_1837	COG0517	IMP dehydrogenase activity
AW22_1838	COG4176	ABC-type proline glycine betaine transport system permease component
AW22_1842	COG0494	nUDIX hydrolase
AW22_1844	COG0572	uridine kinase
AW22_1845	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AW22_1845	COG0456	acetyltransferase
AW22_1846	COG1028	Short-chain dehydrogenase reductase Sdr
AW22_1848	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AW22_1849	COG0022	dehydrogenase e1 component
AW22_1850	COG0508	dehydrogenase complex catalyzes the overall conversion of
AW22_1851	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AW22_1854	COG1959	2 iron, 2 sulfur cluster binding
AW22_1858	COG1349	DNA-binding transcription factor activity
AW22_1859	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AW22_186	COG1530	ribonuclease E activity
AW22_1862	COG3284	Transcriptional regulator
AW22_1867	COG1309	transcriptional regulator
AW22_1873	COG3773	Cell wall hydrolase
AW22_1873	COG3409	Peptidoglycan-binding domain 1 protein
AW22_1874	COG2959	enzyme of heme biosynthesis
AW22_1877	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AW22_188	COG2868	ribosomal protein
AW22_1884	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AW22_1885	COG0697	spore germination
AW22_1887	COG0201	protein transport
AW22_1888	COG0346	lactoylglutathione lyase activity
AW22_1893	COG3227	Zinc metalloprotease (Elastase)
AW22_1894	COG1523	belongs to the glycosyl hydrolase 13 family
AW22_1898	COG1011	Hydrolase
AW22_190	COG3290	protein histidine kinase activity
AW22_1903	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AW22_1910	COG0322	excinuclease ABC activity
AW22_1913	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AW22_1918	COG4667	esterase of the alpha-beta hydrolase superfamily
AW22_192	COG0745	RESPONSE REGULATOR receiver
AW22_1923	COG3878	Protein conserved in bacteria
AW22_1925	COG0406	alpha-ribazole phosphatase activity
AW22_193	COG5002	protein histidine kinase activity
AW22_1930	COG1051	belongs to the nudix hydrolase family
AW22_1931	COG0592	DNA-directed DNA polymerase activity
AW22_1932	COG2816	NAD+ diphosphatase activity
AW22_1933	COG2223	nitrite transmembrane transporter activity
AW22_194	COG1136	(ABC) transporter
AW22_1940	COG0697	spore germination
AW22_1941	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AW22_1945	COG0584	glycerophosphoryl diester phosphodiesterase
AW22_1949	COG2814	Major facilitator Superfamily
AW22_195	COG0577	efflux transmembrane transporter activity
AW22_1952	COG0693	protein deglycase activity
AW22_1958	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AW22_196	COG0577	efflux transmembrane transporter activity
AW22_1960	COG1028	Short-chain dehydrogenase reductase Sdr
AW22_1963	COG0671	phosphoesterase, PA-phosphatase related
AW22_1964	COG0604	alcohol dehydrogenase
AW22_1965	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AW22_1967	COG2205	protein histidine kinase activity
AW22_197	COG0077	Prephenate dehydratase
AW22_1972	COG1794	racemase activity, acting on amino acids and derivatives
AW22_1973	COG1819	glycosyl
AW22_1975	COG5002	protein histidine kinase activity
AW22_1976	COG0561	phosphatase activity
AW22_198	COG2258	MOSC domain
AW22_1983	COG2124	cytochrome p450
AW22_199	COG1827	regulation of RNA biosynthetic process
AW22_200	COG1104	cysteine desulfurase activity
AW22_2000	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AW22_2002	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AW22_2003	COG0460	homoserine dehydrogenase
AW22_2007	COG0577	efflux transmembrane transporter activity
AW22_2008	COG1136	(ABC) transporter
AW22_201	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AW22_2013	COG2205	protein histidine kinase activity
AW22_2014	COG0745	RESPONSE REGULATOR receiver
AW22_2016	COG3773	Cell wall hydrolase
AW22_2017	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
AW22_2019	COG3386	PFAM SMP-30 Gluconolaconase
AW22_202	COG0157	Belongs to the NadC ModD family
AW22_2023	COG1063	alcohol dehydrogenase
AW22_2027	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AW22_2036	COG2814	Major facilitator Superfamily
AW22_2041	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AW22_2041	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AW22_2045	COG3227	Zinc metalloprotease (Elastase)
AW22_2049	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AW22_2054	COG1686	Belongs to the peptidase S11 family
AW22_2055	COG2318	DinB family
AW22_2057	COG0572	uridine kinase
AW22_2058	COG1247	-acetyltransferase
AW22_2060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AW22_2061	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AW22_2062	COG1024	Enoyl-CoA hydratase
AW22_2063	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AW22_2064	COG0511	ligase activity, forming carbon-carbon bonds
AW22_2065	COG0439	Biotin carboxylase
AW22_2066	COG1960	acyl-CoA dehydrogenase activity
AW22_207	COG0640	Transcriptional regulator
AW22_2070	COG0675	Transposase, IS605 OrfB family
AW22_2071	COG1408	metallophosphoesterase
AW22_2072	COG2367	Beta-lactamase
AW22_2074	COG0768	penicillin binding
AW22_2076	COG1595	DNA-templated transcription, initiation
AW22_2080	COG2195	Cleaves the N-terminal amino acid of tripeptides
AW22_2086	COG1846	Transcriptional regulator
AW22_2087	COG3961	Belongs to the TPP enzyme family
AW22_2102	COG0582	viral genome integration into host DNA
AW22_2103	COG3961	Belongs to the TPP enzyme family
AW22_2105	COG3615	Tellurite resistance protein tehB
AW22_2105	COG0500	methyltransferase
AW22_2106	COG1136	(ABC) transporter
AW22_2106	COG0577	efflux transmembrane transporter activity
AW22_2109	COG1309	transcriptional regulator
AW22_211	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AW22_2114	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AW22_2119	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AW22_2121	COG2971	BadF BadG BcrA BcrD
AW22_2126	COG1649	PFAM Uncharacterised BCR, COG1649
AW22_2131	COG1595	DNA-templated transcription, initiation
AW22_2134	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AW22_2141	COG1396	sequence-specific DNA binding
AW22_2145	COG1132	(ABC) transporter
AW22_2146	COG1132	(ABC) transporter
AW22_2149	COG2258	MOSC domain
AW22_2150	COG0583	DNA-binding transcription factor activity
AW22_2153	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AW22_2154	COG0583	DNA-binding transcription factor activity
AW22_2156	COG0010	Belongs to the arginase family
AW22_217	COG1862	Preprotein translocase
AW22_219	COG2323	membrane
AW22_2199	COG0515	serine threonine protein kinase
AW22_2199	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AW22_220	COG2244	polysaccharide biosynthetic process
AW22_2201	COG2002	toxin-antitoxin pair type II binding
AW22_2216	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AW22_2216	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AW22_2217	COG0592	DNA-directed DNA polymerase activity
AW22_222	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AW22_222	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AW22_223	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AW22_2239	COG1278	Cold shock
AW22_224	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AW22_224	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AW22_2241	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AW22_2242	COG2226	methyltransferase
AW22_2250	COG1247	-acetyltransferase
AW22_2257	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AW22_226	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AW22_2266	COG2226	methyltransferase
AW22_2272	COG0596	Alpha beta hydrolase
AW22_2274	COG1136	(ABC) transporter
AW22_2276	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AW22_2277	COG1187	pseudouridine synthase activity
AW22_2278	COG2329	Antibiotic biosynthesis monooxygenase
AW22_2281	COG1115	amino acid carrier protein
AW22_2283	COG2318	DinB family
AW22_2285	COG0776	regulation of translation
AW22_2288	COG2814	Major facilitator Superfamily
AW22_2289	COG3251	PFAM MbtH domain protein
AW22_2290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AW22_2291	COG1535	isochorismatase
AW22_2291	COG3433	isochorismatase activity
AW22_2292	COG1021	2,3-dihydroxybenzoate-AMP ligase
AW22_2293	COG1169	isochorismate synthase
AW22_2294	COG1028	Short-chain dehydrogenase reductase Sdr
AW22_2295	COG2223	nitrite transmembrane transporter activity
AW22_2300	COG0420	3'-5' exonuclease activity
AW22_2303	COG1024	Enoyl-CoA hydratase
AW22_2304	COG1280	lysine exporter protein (LysE YggA)
AW22_2306	COG2084	Dehydrogenase
AW22_2307	COG1960	acyl-CoA dehydrogenase activity
AW22_2308	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AW22_2309	COG2079	MmgE PrpD family protein
AW22_231	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AW22_2310	COG0372	Belongs to the citrate synthase family
AW22_2311	COG4841	protein insertion into membrane
AW22_2312	COG2814	Major facilitator Superfamily
AW22_2314	COG4499	WXG100 protein secretion system (Wss), protein YukC
AW22_2314	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AW22_2318	COG0300	oxidoreductase activity
AW22_2325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AW22_233	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AW22_2337	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AW22_2338	COG0671	phosphoesterase, PA-phosphatase related
AW22_2339	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AW22_234	COG1959	2 iron, 2 sulfur cluster binding
AW22_2340	COG4326	sporulation control protein
AW22_2341	COG3064	Membrane
AW22_2341	COG4991	sh3 domain protein
AW22_2341	COG0515	serine threonine protein kinase
AW22_2348	COG1509	lysine 2,3-aminomutase activity
AW22_2349	COG3829	transcription factor binding
AW22_235	COG1104	cysteine desulfurase activity
AW22_2350	COG0456	acetyltransferase
AW22_2351	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AW22_2352	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AW22_2353	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AW22_2354	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AW22_2357	COG5506	Protein of unknown function (DUF1694)
AW22_2358	COG1012	belongs to the aldehyde dehydrogenase family
AW22_2359	COG1253	flavin adenine dinucleotide binding
AW22_2366	COG1174	glycine betaine transport
AW22_2367	COG0517	IMP dehydrogenase activity
AW22_2367	COG1125	glycine betaine transport
AW22_2374	COG1070	Carbohydrate kinase
AW22_2379	COG1064	alcohol dehydrogenase
AW22_238	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AW22_2380	COG1737	Transcriptional regulator
AW22_2381	COG2197	response regulator
AW22_2382	COG4585	Histidine kinase
AW22_2382	COG2203	Gaf domain
AW22_2383	COG0668	transmembrane transport
AW22_2385	COG1051	belongs to the nudix hydrolase family
AW22_2386	COG1335	isochorismatase
AW22_2390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AW22_2391	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AW22_2395	COG0367	asparagine synthase
AW22_2396	COG0071	Belongs to the small heat shock protein (HSP20) family
AW22_2397	COG1999	signal sequence binding
AW22_2398	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AW22_2399	COG1307	EDD domain protein, DegV family
AW22_24	COG0006	proline dipeptidase activity
AW22_2401	COG0805	protein transport
AW22_2403	COG1272	protein, Hemolysin III
AW22_2404	COG0204	Acyl-transferase
AW22_2406	COG0768	penicillin binding
AW22_2410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AW22_2414	COG0546	phosphoglycolate phosphatase activity
AW22_2416	COG4473	ABC transporter
AW22_2417	COG1131	(ABC) transporter
AW22_2419	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AW22_242	COG0628	permease
AW22_2420	COG0456	acetyltransferase
AW22_2422	COG1794	racemase activity, acting on amino acids and derivatives
AW22_2423	COG1454	alcohol dehydrogenase
AW22_2424	COG2610	gluconate transmembrane transporter activity
AW22_2429	COG0733	neurotransmitter:sodium symporter activity
AW22_2432	COG5002	protein histidine kinase activity
AW22_2432	COG3850	Histidine kinase
AW22_2433	COG0745	RESPONSE REGULATOR receiver
AW22_2434	COG0471	metal ion transport
AW22_2435	COG1929	Belongs to the glycerate kinase type-1 family
AW22_2459	COG5444	nuclease activity
AW22_2464	COG1674	ftsk spoiiie
AW22_2468	COG0017	Asparaginyl-tRNA synthetase
AW22_2469	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AW22_2477	COG2521	methyltransferase
AW22_2477	COG2136	Putative SAM-dependent methyltransferase
AW22_248	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AW22_2480	COG1413	lyase activity
AW22_2483	COG0629	single-stranded DNA binding
AW22_2486	COG0488	(ABC) transporter
AW22_2487	COG1418	mRNA catabolic process
AW22_2492	COG5632	N-Acetylmuramoyl-L-alanine amidase
AW22_2501	COG2359	stage V sporulation protein S
AW22_2508	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
AW22_2509	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AW22_2510	COG2146	nitrite reductase [NAD(P)H] activity
AW22_2511	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AW22_2511	COG1587	Uroporphyrinogen-III synthase
AW22_2513	COG1648	precorrin-2 dehydrogenase activity
AW22_2515	COG2223	nitrite transmembrane transporter activity
AW22_2517	COG0314	molybdopterin synthase activity
AW22_2518	COG0303	'Molybdopterin
AW22_2519	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AW22_2520	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AW22_2521	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AW22_2522	COG2181	nitrate reductase activity
AW22_2523	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
AW22_2524	COG1140	nitrate reductase beta subunit
AW22_2525	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AW22_2528	COG0714	Associated with various cellular activities
AW22_2529	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
AW22_2530	COG1305	Transglutaminase-like
AW22_2531	COG0386	Belongs to the glutathione peroxidase family
AW22_2533	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AW22_2533	COG0426	domain, Protein
AW22_2536	COG1595	DNA-templated transcription, initiation
AW22_2539	COG0346	lactoylglutathione lyase activity
AW22_254	COG0768	penicillin binding
AW22_2540	COG1082	Xylose isomerase domain protein TIM barrel
AW22_2544	COG2226	methyltransferase
AW22_2549	COG3874	Sporulation protein YtfJ
AW22_2565	COG0456	acetyltransferase
AW22_2571	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AW22_2572	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AW22_2573	COG1819	glycosyl
AW22_2577	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AW22_2579	COG0561	phosphatase activity
AW22_2581	COG1942	4-Oxalocrotonate Tautomerase
AW22_2587	COG0251	oxidation-reduction process
AW22_259	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AW22_2590	COG0196	riboflavin kinase activity
AW22_2592	COG2368	4-hydroxyphenylacetate
AW22_2595	COG2211	Major facilitator Superfamily
AW22_2596	COG0154	amidase activity
AW22_2598	COG1876	peptidase activity
AW22_260	COG0626	cystathionine gamma-synthase activity
AW22_2600	COG0860	N-Acetylmuramoyl-L-alanine amidase
AW22_2603	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AW22_2604	COG1114	Component of the transport system for branched-chain amino acids
AW22_2607	COG1253	flavin adenine dinucleotide binding
AW22_2608	COG2839	Protein conserved in bacteria
AW22_2609	COG0702	epimerase
AW22_261	COG1454	alcohol dehydrogenase
AW22_261	COG1012	belongs to the aldehyde dehydrogenase family
AW22_2612	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AW22_2613	COG1607	acyl-coa hydrolase
AW22_2614	COG3689	TIGRFAM TIGR03943 family protein
AW22_2615	COG0701	Predicted permease
AW22_2617	COG2244	polysaccharide biosynthetic process
AW22_2618	COG0586	Pfam SNARE associated Golgi protein
AW22_2619	COG1051	belongs to the nudix hydrolase family
AW22_2620	COG5337	Spore coat protein CotH
AW22_2622	COG0406	alpha-ribazole phosphatase activity
AW22_2625	COG4166	transmembrane transport
AW22_2627	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AW22_2629	COG0702	epimerase
AW22_263	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AW22_2631	COG0803	Belongs to the bacterial solute-binding protein 9 family
AW22_2631	COG3443	Belongs to the bacterial solute-binding protein 9 family
AW22_2635	COG0456	acetyltransferase
AW22_2636	COG0523	cobalamin synthesis protein
AW22_2637	COG4989	oxidoreductase activity
AW22_2639	COG1231	oxidoreductase activity
AW22_2641	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AW22_2644	COG0783	Belongs to the Dps family
AW22_2645	COG3949	Membrane
AW22_2648	COG0840	transmembrane signaling receptor activity
AW22_2653	COG2814	Major facilitator Superfamily
AW22_2654	COG0667	Aldo Keto reductase
AW22_2655	COG0640	Transcriptional regulator
AW22_2656	COG1404	Belongs to the peptidase S8 family
AW22_2657	COG2002	toxin-antitoxin pair type II binding
AW22_2658	COG0577	efflux transmembrane transporter activity
AW22_2665	COG1752	Esterase of the alpha-beta hydrolase superfamily
AW22_2667	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AW22_2668	COG1279	arginine transmembrane transporter activity
AW22_2669	COG2814	Major facilitator Superfamily
AW22_2671	COG1082	Xylose isomerase domain protein TIM barrel
AW22_2674	COG0318	PFAM AMP-dependent synthetase and ligase
AW22_2675	COG4264	IucA IucC family
AW22_2677	COG1247	-acetyltransferase
AW22_2678	COG1285	pathogenesis
AW22_2680	COG0726	polysaccharide deacetylase
AW22_2681	COG5002	protein histidine kinase activity
AW22_2682	COG0745	RESPONSE REGULATOR receiver
AW22_2684	COG1316	TRANSCRIPTIONal
AW22_2689	COG0460	homoserine dehydrogenase
AW22_2693	COG0726	polysaccharide deacetylase
AW22_2696	COG0300	oxidoreductase activity
AW22_2698	COG5002	protein histidine kinase activity
AW22_2699	COG0745	RESPONSE REGULATOR receiver
AW22_27	COG4109	DRTGG domain
AW22_2700	COG1132	(ABC) transporter
AW22_2702	COG0791	NLP P60 protein
AW22_2702	COG1388	LysM domain
AW22_2704	COG1686	Belongs to the peptidase S11 family
AW22_2707	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AW22_2708	COG4988	ABC transporter
AW22_2709	COG1294	oxidase, subunit
AW22_271	COG2259	Doxx family
AW22_2710	COG1271	oxidase subunit
AW22_2714	COG1942	4-Oxalocrotonate Tautomerase
AW22_2716	COG0583	DNA-binding transcription factor activity
AW22_2718	COG0559	Belongs to the binding-protein-dependent transport system permease family
AW22_272	COG2514	catechol 2,3-dioxygenase activity
AW22_2720	COG0411	ABC transporter
AW22_2722	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AW22_2723	COG2030	dehydratase
AW22_2724	COG0318	PFAM AMP-dependent synthetase and ligase
AW22_2727	COG0523	cobalamin synthesis protein
AW22_2728	COG1231	oxidoreductase activity
AW22_2729	COG0039	L-malate dehydrogenase activity
AW22_2730	COG0628	permease
AW22_2733	COG0778	Nitroreductase
AW22_2734	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AW22_2735	COG1959	2 iron, 2 sulfur cluster binding
AW22_2736	COG0583	DNA-binding transcription factor activity
AW22_2737	COG0697	spore germination
AW22_2739	COG4549	nuclear export factor GLE1
AW22_274	COG3186	Phenylalanine-4-hydroxylase
AW22_2740	COG2372	response to copper ion
AW22_2740	COG1276	copper resistance
AW22_2742	COG1114	Component of the transport system for branched-chain amino acids
AW22_275	COG1404	Belongs to the peptidase S8 family
AW22_2752	COG0464	growth
AW22_2754	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AW22_2755	COG0076	glutamate decarboxylase activity
AW22_2757	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
AW22_2768	COG2132	Multicopper oxidase
AW22_2769	COG0006	proline dipeptidase activity
AW22_2774	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AW22_2775	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AW22_2777	COG2390	Transcriptional regulator
AW22_2778	COG2205	protein histidine kinase activity
AW22_2779	COG0745	RESPONSE REGULATOR receiver
AW22_2788	COG0531	amino acid
AW22_2790	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AW22_2793	COG1914	H( )-stimulated, divalent metal cation uptake system
AW22_2798	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AW22_2803	COG4166	transmembrane transport
AW22_281	COG2267	carboxylic ester hydrolase activity
AW22_2810	COG0427	acetyl-CoA hydrolase
AW22_2811	COG3279	Response regulator of the LytR AlgR family
AW22_2815	COG3384	dioxygenase
AW22_2816	COG2814	Major facilitator Superfamily
AW22_2820	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AW22_2822	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AW22_2824	COG0028	Belongs to the TPP enzyme family
AW22_2825	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AW22_2827	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AW22_283	COG1785	Belongs to the alkaline phosphatase family
AW22_2831	COG2084	Dehydrogenase
AW22_2834	COG2323	membrane
AW22_2835	COG5566	PFAM Mor transcription activator
AW22_2837	COG0733	neurotransmitter:sodium symporter activity
AW22_2838	COG2244	polysaccharide biosynthetic process
AW22_2841	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AW22_2842	COG2223	nitrite transmembrane transporter activity
AW22_2843	COG4166	transmembrane transport
AW22_2844	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AW22_2846	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AW22_2847	COG0477	Major facilitator Superfamily
AW22_2849	COG1966	Carbon starvation protein
AW22_285	COG2357	RelA SpoT domain protein
AW22_2854	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AW22_2857	COG1051	belongs to the nudix hydrolase family
AW22_286	COG0778	Nitroreductase
AW22_2867	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AW22_2868	COG0784	Response regulator, receiver
AW22_2869	COG4191	Histidine kinase
AW22_2870	COG0281	malic enzyme
AW22_2871	COG1027	Aspartate ammonia-lyase
AW22_2873	COG0528	UMP kinase activity
AW22_2874	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AW22_2877	COG1131	(ABC) transporter
AW22_288	COG1595	DNA-templated transcription, initiation
AW22_2884	COG2733	membrane
AW22_2890	COG0785	Cytochrome C biogenesis protein
AW22_2894	COG3340	Belongs to the peptidase S51 family
AW22_2895	COG0534	Mate efflux family protein
AW22_2898	COG0114	fumarate hydratase activity
AW22_2899	COG1757	Na H antiporter
AW22_290	COG1191	sigma factor activity
AW22_2902	COG0701	Predicted permease
AW22_2903	COG0523	cobalamin synthesis protein
AW22_2904	COG0697	spore germination
AW22_2905	COG1802	Transcriptional regulator
AW22_2911	COG0367	asparagine synthase
AW22_2913	COG1846	Transcriptional regulator
AW22_2916	COG0406	alpha-ribazole phosphatase activity
AW22_2918	COG1686	Belongs to the peptidase S11 family
AW22_2926	COG1028	Short-chain dehydrogenase reductase Sdr
AW22_2929	COG1234	tRNA 3'-trailer cleavage
AW22_293	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AW22_2930	COG1177	transmembrane transport
AW22_2932	COG3842	ATPase activity
AW22_2938	COG2329	Antibiotic biosynthesis monooxygenase
AW22_294	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AW22_2949	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AW22_2950	COG4786	Flagellar basal body rod
AW22_2951	COG1419	protein localization to endoplasmic reticulum
AW22_2952	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AW22_2953	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AW22_2955	COG1987	bacterial-type flagellum assembly
AW22_2956	COG1338	Plays a role in the flagellum-specific transport system
AW22_2958	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AW22_2958	COG1776	CheC inhibitor of MCP methylation
AW22_2959	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AW22_296	COG1534	Rna-binding protein
AW22_2961	COG0741	lytic transglycosylase activity
AW22_2962	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AW22_2963	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AW22_2965	COG0784	Response regulator, receiver
AW22_2965	COG0835	chemotaxis
AW22_2968	COG1749	Flagellar hook protein flgE
AW22_2972	COG1157	protein secretion by the type III secretion system
AW22_2974	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AW22_2975	COG1766	The M ring may be actively involved in energy transduction
AW22_2976	COG1677	Flagellar hook-basal body complex protein FliE
AW22_2977	COG1558	bacterial-type flagellum-dependent cell motility
AW22_2978	COG1815	bacterial-type flagellum-dependent cell motility
AW22_298	COG1713	HD superfamily hydrolase involved in NAD metabolism
AW22_2982	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AW22_2983	COG1256	bacterial-type flagellum assembly
AW22_2987	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AW22_299	COG0799	negative regulation of ribosome biogenesis
AW22_2990	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AW22_2990	COG1776	CheC inhibitor of MCP methylation
AW22_2991	COG2198	Histidine kinase
AW22_2991	COG0643	Histidine kinase
AW22_2992	COG2201	protein-glutamate methylesterase activity
AW22_2993	COG1360	Flagellar Motor Protein
AW22_2994	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AW22_2996	COG1923	regulation of RNA biosynthetic process
AW22_300	COG2226	methyltransferase
AW22_3007	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AW22_3008	COG2323	membrane
AW22_301	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AW22_3010	COG4978	Transcriptional regulator
AW22_3010	COG0789	Transcriptional regulator
AW22_3011	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AW22_3012	COG0475	glutathione-regulated potassium exporter activity
AW22_3014	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AW22_3015	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AW22_3016	COG3162	membrane
AW22_3019	COG1280	lysine exporter protein (LysE YggA)
AW22_302	COG1555	photosystem II stabilization
AW22_302	COG1596	polysaccharide export
AW22_3020	COG3403	YqcI/YcgG family
AW22_3027	COG0328	RNA-DNA hybrid ribonuclease activity
AW22_303	COG2131	deaminase
AW22_3031	COG0454	-acetyltransferase
AW22_304	COG0658	competence protein
AW22_304	COG2333	competence protein COMEC
AW22_3045	COG5632	N-Acetylmuramoyl-L-alanine amidase
AW22_306	COG1466	dna polymerase III delta subunit
AW22_3061	COG4626	Terminase
AW22_3061	COG1802	Transcriptional regulator
AW22_3086	COG3800	Transcriptional regulator
AW22_3086	COG1396	sequence-specific DNA binding
AW22_3091	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AW22_3094	COG0754	glutathionylspermidine amidase activity
AW22_31	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AW22_3100	COG0456	acetyltransferase
AW22_3102	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AW22_3104	COG2311	Membrane
AW22_3105	COG2233	PERMEase
AW22_3107	COG0024	Methionine aminopeptidase
AW22_3108	COG3173	Aminoglycoside phosphotransferase
AW22_311	COG1733	regulation of RNA biosynthetic process
AW22_3110	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AW22_3111	COG1199	ATP-dependent helicase activity
AW22_3113	COG0116	Belongs to the methyltransferase superfamily
AW22_312	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AW22_3124	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AW22_3124	COG4499	WXG100 protein secretion system (Wss), protein YukC
AW22_3126	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AW22_3127	COG3935	DnaD domain protein
AW22_3131	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AW22_3131	COG1199	ATP-dependent helicase activity
AW22_3138	COG0438	transferase activity, transferring glycosyl groups
AW22_3139	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AW22_314	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AW22_3142	COG1694	Mazg nucleotide pyrophosphohydrolase
AW22_3143	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AW22_3145	COG2738	Putative neutral zinc metallopeptidase
AW22_3148	COG4347	Protein of unknown function (DUF1405)
AW22_3150	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AW22_3154	COG0457	Tetratricopeptide repeat
AW22_3155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AW22_3158	COG0105	UTP biosynthetic process
AW22_3159	COG0142	geranyltranstransferase activity
AW22_3161	COG0142	geranyltranstransferase activity
AW22_3164	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AW22_3178	COG0252	asparaginase activity
AW22_3179	COG0492	ferredoxin-NADP+ reductase activity
AW22_318	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AW22_3183	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AW22_3184	COG4862	establishment of competence for transformation
AW22_3186	COG1408	metallophosphoesterase
AW22_3188	COG1266	CAAX protease self-immunity
AW22_3189	COG0514	ATP-dependent DNA helicase (RecQ)
AW22_319	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AW22_3191	COG1141	Ferredoxin
AW22_3192	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AW22_3194	COG4942	peptidase
AW22_3195	COG2096	Adenosyltransferase
AW22_3196	COG5002	protein histidine kinase activity
AW22_3197	COG0745	RESPONSE REGULATOR receiver
AW22_3198	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AW22_3199	COG1333	cytochrome c biogenesis protein
AW22_3201	COG1187	pseudouridine synthase activity
AW22_3202	COG0700	Nucleoside recognition
AW22_3203	COG2715	membrane protein required for spore maturation
AW22_3204	COG1686	Belongs to the peptidase S11 family
AW22_3205	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AW22_3208	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AW22_3208	COG0392	lysyltransferase activity
AW22_321	COG1610	YqeY-like protein
AW22_3212	COG5002	protein histidine kinase activity
AW22_3213	COG0582	viral genome integration into host DNA
AW22_3215	COG1801	Protein of unknown function DUF72
AW22_3216	COG3852	Histidine kinase
AW22_3219	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AW22_3220	COG1392	Phosphate transport regulator
AW22_3221	COG0306	phosphate transporter
AW22_3222	COG0730	response to heat
AW22_3231	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AW22_3233	COG1114	Component of the transport system for branched-chain amino acids
AW22_3235	COG2197	response regulator
AW22_3236	COG4585	Histidine kinase
AW22_3237	COG4758	membrane
AW22_324	COG1702	phosphate starvation-inducible protein PhoH
AW22_3240	COG1757	Na H antiporter
AW22_3244	COG0733	neurotransmitter:sodium symporter activity
AW22_3245	COG1648	precorrin-2 dehydrogenase activity
AW22_3249	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AW22_325	COG1480	7TM receptor with intracellular HD hydrolase
AW22_3250	COG0529	Catalyzes the synthesis of activated sulfate
AW22_3254	COG0019	diaminopimelate decarboxylase activity
AW22_3256	COG1368	sulfuric ester hydrolase activity
AW22_3257	COG1183	phosphatidylcholine synthase activity
AW22_3260	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AW22_327	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AW22_3275	COG0440	acetolactate synthase activity
AW22_3276	COG0028	Belongs to the TPP enzyme family
AW22_3277	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AW22_328	COG0295	cytidine deaminase activity
AW22_3282	COG3874	Sporulation protein YtfJ
AW22_3283	COG4709	membrane
AW22_3284	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AW22_3285	COG1301	dicarboxylic acid transport
AW22_3287	COG1846	Transcriptional regulator
AW22_329	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AW22_3290	COG1968	undecaprenyl-diphosphatase activity
AW22_3291	COG0534	Mate efflux family protein
AW22_3298	COG0716	FMN binding
AW22_3303	COG1696	Membrane protein involved in D-alanine export
AW22_3305	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AW22_3306	COG2070	2-Nitropropane dioxygenase
AW22_3307	COG1619	proteins homologs of microcin C7 resistance protein MccF
AW22_3309	COG1335	isochorismatase
AW22_3311	COG1522	sequence-specific DNA binding
AW22_3314	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AW22_3315	COG1131	(ABC) transporter
AW22_3317	COG1131	(ABC) transporter
AW22_3318	COG1725	Transcriptional regulator
AW22_3319	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AW22_332	COG0517	IMP dehydrogenase activity
AW22_3320	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AW22_3320	COG1372	Participates in initiation and elongation during chromosome replication
AW22_3321	COG1403	HNH endonuclease
AW22_3322	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AW22_3323	COG1780	Probably involved in ribonucleotide reductase function
AW22_3329	COG4873	Protein conserved in bacteria
AW22_3332	COG0720	synthase
AW22_3334	COG5002	protein histidine kinase activity
AW22_3336	COG2318	DinB family
AW22_3338	COG1846	Transcriptional regulator
AW22_3339	COG3852	Histidine kinase
AW22_334	COG0358	DNA primase activity
AW22_3341	COG2861	carbohydrate metabolic process
AW22_3343	COG0235	Class ii aldolase
AW22_3346	COG1349	DNA-binding transcription factor activity
AW22_335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AW22_3351	COG3842	ATPase activity
AW22_3352	COG1840	ABC-type Fe3 transport system, periplasmic component
AW22_3355	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AW22_3357	COG3243	poly(R)-hydroxyalkanoic acid synthase
AW22_3358	COG1028	Short-chain dehydrogenase reductase Sdr
AW22_336	COG2010	Cytochrome c
AW22_3362	COG2030	dehydratase
AW22_3364	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AW22_3365	COG0861	Integral membrane protein TerC family
AW22_3366	COG2116	formate transmembrane transporter activity
AW22_3368	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AW22_337	COG2384	SAM-dependent methyltransferase
AW22_3372	COG2186	Transcriptional regulator
AW22_3373	COG5002	protein histidine kinase activity
AW22_3374	COG0745	RESPONSE REGULATOR receiver
AW22_3376	COG3835	regulator
AW22_3377	COG0277	FAD linked oxidase domain protein
AW22_3378	COG0247	lactate metabolic process
AW22_3379	COG2340	Cysteine-rich secretory protein family
AW22_338	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AW22_3381	COG0564	pseudouridine synthase activity
AW22_3383	COG2409	Drug exporters of the RND superfamily
AW22_3385	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AW22_3386	COG1177	transmembrane transport
AW22_3387	COG1176	ABC-type spermidine putrescine transport system, permease component I
AW22_3389	COG1012	belongs to the aldehyde dehydrogenase family
AW22_3395	COG0681	Belongs to the peptidase S26 family
AW22_3396	COG1686	Belongs to the peptidase S11 family
AW22_34	COG0587	DNA-directed DNA polymerase activity
AW22_3401	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AW22_3403	COG5293	efflux transmembrane transporter activity
AW22_3416	COG1476	TRANSCRIPTIONal
AW22_3418	COG0508	dehydrogenase complex catalyzes the overall conversion of
AW22_3422	COG2226	methyltransferase
AW22_3429	COG5634	Uncharacterized conserved protein (DUF2278)
AW22_3430	COG1620	l-lactate permease
AW22_3437	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AW22_3437	COG0512	Glutamine amidotransferase of anthranilate synthase
AW22_3439	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AW22_344	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AW22_3440	COG5492	domain, Protein
AW22_3443	COG2382	esterase
AW22_3445	COG2153	protein acetylation
AW22_345	COG1121	(ABC) transporter
AW22_3454	COG1091	dTDP-4-dehydrorhamnose reductase activity
AW22_3457	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AW22_346	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AW22_3461	COG0457	Tetratricopeptide repeat
AW22_3461	COG0463	Glycosyl transferase, family 2
AW22_3465	COG1216	Glycosyl transferase, family 2
AW22_3466	COG0772	Belongs to the SEDS family
AW22_3469	COG0564	pseudouridine synthase activity
AW22_347	COG0735	belongs to the Fur family
AW22_3470	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AW22_3471	COG2357	RelA SpoT domain protein
AW22_3473	COG4116	CYTH
AW22_3474	COG2346	COG2346, Truncated hemoglobins
AW22_3477	COG1164	Oligoendopeptidase f
AW22_3479	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AW22_3480	COG4862	establishment of competence for transformation
AW22_3481	COG0861	Integral membrane protein TerC family
AW22_3482	COG1393	Belongs to the ArsC family
AW22_3484	COG4166	transmembrane transport
AW22_3485	COG0534	Mate efflux family protein
AW22_3486	COG4608	Belongs to the ABC transporter superfamily
AW22_3487	COG0444	Belongs to the ABC transporter superfamily
AW22_3488	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AW22_3489	COG0601	transmembrane transport
AW22_3490	COG4166	transmembrane transport
AW22_3492	COG0180	Tryptophanyl-tRNA synthetase
AW22_3494	COG5504	Zn-dependent protease
AW22_3495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AW22_3496	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AW22_3499	COG2267	carboxylic ester hydrolase activity
AW22_35	COG0281	malic enzyme
AW22_3501	COG0542	response to heat
AW22_3503	COG0561	phosphatase activity
AW22_3506	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AW22_3508	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AW22_3510	COG2996	Protein conserved in bacteria
AW22_3514	COG0004	ammonium transporteR
AW22_3515	COG0753	catalase activity
AW22_3517	COG0367	asparagine synthase
AW22_352	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AW22_3522	COG0179	Fumarylacetoacetate (FAA) hydrolase
AW22_353	COG0477	Major facilitator Superfamily
AW22_3534	COG0398	Pfam SNARE associated Golgi protein
AW22_3536	COG4903	ComK protein
AW22_3539	COG1278	Cold shock
AW22_3541	COG2224	Isocitrate lyase
AW22_3542	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AW22_3543	COG0497	DNA recombination
AW22_3546	COG0697	spore germination
AW22_3547	COG0501	Belongs to the peptidase M48B family
AW22_355	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AW22_3552	COG0745	RESPONSE REGULATOR receiver
AW22_3553	COG2205	protein histidine kinase activity
AW22_3554	COG2207	Transcriptional regulator
AW22_3554	COG3708	Transcriptional regulator
AW22_3555	COG1595	DNA-templated transcription, initiation
AW22_3557	COG1078	dGTPase activity
AW22_3559	COG1408	metallophosphoesterase
AW22_356	COG0573	inorganic phosphate transmembrane transporter activity
AW22_3560	COG1073	alpha beta
AW22_357	COG0581	inorganic phosphate transmembrane transporter activity
AW22_3572	COG0318	PFAM AMP-dependent synthetase and ligase
AW22_3574	COG0095	Lipoate-protein ligase
AW22_3575	COG1234	tRNA 3'-trailer cleavage
AW22_3577	COG1609	Transcriptional regulator
AW22_358	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AW22_3582	COG1511	domain protein
AW22_3583	COG1309	transcriptional regulator
AW22_359	COG0704	Plays a role in the regulation of phosphate uptake
AW22_3594	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AW22_3595	COG2329	Antibiotic biosynthesis monooxygenase
AW22_3596	COG3428	Bacterial PH domain
AW22_3597	COG3402	PFAM membrane-flanked domain
AW22_36	COG1725	Transcriptional regulator
AW22_360	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AW22_3603	COG0778	Nitroreductase
AW22_3608	COG3428	Bacterial PH domain
AW22_3609	COG3402	PFAM membrane-flanked domain
AW22_3611	COG1309	transcriptional regulator
AW22_362	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AW22_3626	COG4473	ABC transporter
AW22_3627	COG1131	(ABC) transporter
AW22_3628	COG0537	adenosine 5'-monophosphoramidase activity
AW22_3629	COG4980	gas vesicle protein
AW22_363	COG4483	Protein conserved in bacteria
AW22_3633	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AW22_3634	COG3973	AAA domain
AW22_3636	COG0477	Major facilitator Superfamily
AW22_3637	COG0477	Major facilitator Superfamily
AW22_364	COG1940	carbohydrate kinase activity
AW22_3647	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AW22_3649	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AW22_3650	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AW22_3654	COG2267	carboxylic ester hydrolase activity
AW22_3656	COG0457	Tetratricopeptide repeat
AW22_3658	COG0346	lactoylglutathione lyase activity
AW22_3659	COG0346	lactoylglutathione lyase activity
AW22_366	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AW22_3665	COG4717	serine-type aminopeptidase activity
AW22_3666	COG0420	3'-5' exonuclease activity
AW22_3671	COG2197	response regulator
AW22_3672	COG4585	Histidine kinase
AW22_3675	COG0393	Putative heavy-metal-binding
AW22_3680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AW22_3680	COG0784	Response regulator, receiver
AW22_3680	COG2198	Histidine kinase
AW22_3680	COG2205	protein histidine kinase activity
AW22_3681	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AW22_3682	COG2208	phosphoserine phosphatase activity
AW22_3684	COG1191	sigma factor activity
AW22_369	COG0626	cystathionine gamma-synthase activity
AW22_370	COG0626	cystathionine gamma-synthase activity
AW22_3701	COG0457	Tetratricopeptide repeat
AW22_3704	COG1959	2 iron, 2 sulfur cluster binding
AW22_3705	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AW22_3706	COG2376	Dihydroxyacetone kinase
AW22_3708	COG2376	Dihydroxyacetone kinase
AW22_371	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AW22_371	COG0646	methionine synthase
AW22_3719	COG1183	phosphatidylcholine synthase activity
AW22_372	COG1410	methionine synthase
AW22_372	COG0646	methionine synthase
AW22_3723	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AW22_3723	COG3320	Male sterility
AW22_3741	COG1401	restriction endodeoxyribonuclease activity
AW22_3743	COG0305	Participates in initiation and elongation during chromosome replication
AW22_3746	COG0789	Transcriptional regulator
AW22_3746	COG4978	Transcriptional regulator
AW22_3755	COG3181	Tripartite tricarboxylate transporter family receptor
AW22_3756	COG4565	transcriptional regulatory protein
AW22_3757	COG3290	protein histidine kinase activity
AW22_3758	COG0477	Major facilitator Superfamily
AW22_3762	COG3938	Belongs to the proline racemase family
AW22_3766	COG1363	Peptidase, m42
AW22_3770	COG1024	Enoyl-CoA hydratase
AW22_3774	COG4196	transglutaminase domain protein
AW22_3775	COG0860	N-Acetylmuramoyl-L-alanine amidase
AW22_3777	COG2244	polysaccharide biosynthetic process
AW22_3783	COG0659	secondary active sulfate transmembrane transporter activity
AW22_3786	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AW22_3787	COG5632	N-Acetylmuramoyl-L-alanine amidase
AW22_3787	COG3409	Peptidoglycan-binding domain 1 protein
AW22_3788	COG0561	phosphatase activity
AW22_3790	COG3527	Alpha-acetolactate decarboxylase
AW22_3791	COG0028	Belongs to the TPP enzyme family
AW22_3800	COG4585	Histidine kinase
AW22_3805	COG0189	ligase activity
AW22_3808	COG1126	abc transporter atp-binding protein
AW22_3809	COG0765	amino acid transport
AW22_3810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AW22_3811	COG1132	(ABC) transporter
AW22_3812	COG1132	(ABC) transporter
AW22_3813	COG1012	belongs to the aldehyde dehydrogenase family
AW22_3816	COG0531	amino acid
AW22_3818	COG0693	protein deglycase activity
AW22_3818	COG0753	catalase activity
AW22_3819	COG0693	protein deglycase activity
AW22_382	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AW22_3820	COG0693	protein deglycase activity
AW22_3822	COG2211	Major facilitator Superfamily
AW22_3823	COG4533	DNA binding
AW22_3824	COG2814	Major facilitator Superfamily
AW22_3825	COG1309	transcriptional regulator
AW22_3826	COG2076	Multidrug Resistance protein
AW22_3827	COG2076	Multidrug Resistance protein
AW22_3829	COG1522	sequence-specific DNA binding
AW22_383	COG1459	type II secretion system
AW22_3833	COG2259	Doxx family
AW22_3836	COG1263	PTS System
AW22_3836	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AW22_3838	COG1737	Transcriptional regulator
AW22_3840	COG0475	glutathione-regulated potassium exporter activity
AW22_3841	COG0531	amino acid
AW22_3848	COG0586	Pfam SNARE associated Golgi protein
AW22_385	COG4970	Tfp pilus assembly protein FimT
AW22_3855	COG3546	catalase activity
AW22_3856	COG1114	Component of the transport system for branched-chain amino acids
AW22_3857	COG0577	efflux transmembrane transporter activity
AW22_3860	COG5522	Integral membrane protein (intg_mem_TP0381)
AW22_3862	COG1136	(ABC) transporter
AW22_3863	COG0577	efflux transmembrane transporter activity
AW22_3864	COG1388	LysM domain
AW22_3864	COG3584	3D domain protein
AW22_3868	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AW22_3869	COG1447	Phosphotransferase system cellobiose-specific component IIA
AW22_3870	COG3711	transcriptional antiterminator
AW22_3870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AW22_3873	COG1283	sodium-dependent phosphate transmembrane transporter activity
AW22_3874	COG0604	alcohol dehydrogenase
AW22_3875	COG1316	TRANSCRIPTIONal
AW22_3877	COG0730	response to heat
AW22_3878	COG2210	Belongs to the sulfur carrier protein TusA family
AW22_3880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AW22_3881	COG0425	Belongs to the sulfur carrier protein TusA family
AW22_3882	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AW22_3882	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AW22_3883	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AW22_3883	COG0425	Belongs to the sulfur carrier protein TusA family
AW22_3884	COG1937	Protein conserved in bacteria
AW22_3885	COG0446	pyridine nucleotide-disulphide oxidoreductase
AW22_3894	COG2719	SpoVR family
AW22_3895	COG0778	Nitroreductase
AW22_3902	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AW22_3903	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AW22_3905	COG1609	Transcriptional regulator
AW22_3906	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AW22_3906	COG1263	PTS System
AW22_3907	COG1621	beta-fructofuranosidase activity
AW22_3908	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AW22_3911	COG1028	Short-chain dehydrogenase reductase Sdr
AW22_3912	COG2252	PERMEase
AW22_3914	COG1136	(ABC) transporter
AW22_3914	COG0577	efflux transmembrane transporter activity
AW22_3919	COG1846	Transcriptional regulator
AW22_3920	COG2814	Major facilitator Superfamily
AW22_3921	COG2205	protein histidine kinase activity
AW22_3928	COG0351	phosphomethylpyrimidine kinase
AW22_3929	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AW22_3931	COG2104	thiamine diphosphate biosynthetic process
AW22_3932	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AW22_3933	COG0352	thiamine-phosphate diphosphorylase activity
AW22_3934	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AW22_3935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AW22_3936	COG1116	anion transmembrane transporter activity
AW22_3937	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AW22_3941	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AW22_396	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AW22_3965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AW22_3967	COG0581	inorganic phosphate transmembrane transporter activity
AW22_3968	COG0573	inorganic phosphate transmembrane transporter activity
AW22_3969	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AW22_3970	COG1918	ferrous iron import across plasma membrane
AW22_3970	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AW22_3971	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AW22_3972	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AW22_3974	COG0531	amino acid
AW22_3975	COG0697	spore germination
AW22_3976	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AW22_3979	COG4990	cell redox homeostasis
AW22_3980	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AW22_3981	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AW22_3984	COG0475	glutathione-regulated potassium exporter activity
AW22_3984	COG0569	domain protein
AW22_3986	COG2153	protein acetylation
AW22_3989	COG2252	PERMEase
AW22_3990	COG1113	amino acid transport
AW22_3993	COG1114	Component of the transport system for branched-chain amino acids
AW22_3995	COG3104	oligopeptide transport
AW22_3998	COG1476	TRANSCRIPTIONal
AW22_3999	COG1388	LysM domain
AW22_3999	COG3584	3D domain protein
AW22_4000	COG0840	transmembrane signaling receptor activity
AW22_4006	COG3568	Endonuclease Exonuclease Phosphatase
AW22_4009	COG1063	alcohol dehydrogenase
AW22_4012	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AW22_4013	COG1879	ABC-type sugar transport system periplasmic component
AW22_4014	COG1172	Belongs to the binding-protein-dependent transport system permease family
AW22_4015	COG1129	ABC transporter
AW22_4017	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AW22_4018	COG1609	Transcriptional regulator
AW22_4019	COG0477	Major facilitator Superfamily
AW22_402	COG1725	Transcriptional regulator
AW22_4020	COG1846	Transcriptional regulator
AW22_4021	COG2271	Major facilitator Superfamily
AW22_4023	COG4608	Belongs to the ABC transporter superfamily
AW22_4024	COG0601	transmembrane transport
AW22_4026	COG0747	negative chemotaxis
AW22_4029	COG0659	secondary active sulfate transmembrane transporter activity
AW22_403	COG1131	(ABC) transporter
AW22_4032	COG5002	protein histidine kinase activity
AW22_4033	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AW22_4034	COG2378	regulation of single-species biofilm formation
AW22_4039	COG0833	amino acid
AW22_4040	COG0765	amino acid transport
AW22_4041	COG0765	amino acid transport
AW22_4042	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AW22_4043	COG1126	abc transporter atp-binding protein
AW22_4044	COG1115	amino acid carrier protein
AW22_4045	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AW22_4048	COG1404	Belongs to the peptidase S8 family
AW22_4049	COG2197	response regulator
AW22_4050	COG4585	Histidine kinase
AW22_4051	COG0697	spore germination
AW22_4054	COG0366	Alpha amylase catalytic
AW22_4055	COG1263	PTS System
AW22_4055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AW22_4056	COG2188	Transcriptional regulator
AW22_4057	COG0531	amino acid
AW22_4060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AW22_4061	COG0714	Associated with various cellular activities
AW22_4062	COG4548	von Willebrand factor, type A
AW22_4064	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AW22_4065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AW22_4066	COG0156	8-amino-7-oxononanoate synthase activity
AW22_4067	COG2226	methyltransferase
AW22_4069	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AW22_4070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AW22_4071	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AW22_4072	COG3104	oligopeptide transport
AW22_4075	COG1620	l-lactate permease
AW22_4076	COG1027	Aspartate ammonia-lyase
AW22_4077	COG1253	flavin adenine dinucleotide binding
AW22_4078	COG0346	lactoylglutathione lyase activity
AW22_4079	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AW22_4080	COG1316	TRANSCRIPTIONal
AW22_4081	COG2720	vancomycin resistance protein
AW22_4086	COG3227	Zinc metalloprotease (Elastase)
AW22_4089	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AW22_4090	COG2217	Heavy metal translocating P-type atpase
AW22_4091	COG0640	Transcriptional regulator
AW22_4092	COG0531	amino acid
AW22_4095	COG2427	Protein of unknown function (DUF1641)
AW22_4096	COG3383	formate dehydrogenase (NAD+) activity
AW22_4097	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AW22_4098	COG0454	-acetyltransferase
AW22_4098	COG0456	acetyltransferase
AW22_41	COG3030	protein affecting phage T7 exclusion by the F plasmid
AW22_410	COG2076	Multidrug Resistance protein
AW22_4100	COG0745	RESPONSE REGULATOR receiver
AW22_4101	COG5002	protein histidine kinase activity
AW22_4103	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AW22_4106	COG0281	malic enzyme
AW22_4107	COG3493	citrate carrier protein
AW22_4108	COG4565	transcriptional regulatory protein
AW22_4109	COG3290	protein histidine kinase activity
AW22_411	COG2076	Multidrug Resistance protein
AW22_4111	COG4990	cell redox homeostasis
AW22_4113	COG5002	protein histidine kinase activity
AW22_4114	COG0745	RESPONSE REGULATOR receiver
AW22_4115	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AW22_4117	COG0395	ABC-type sugar transport system, permease component
AW22_4118	COG1175	transmembrane transport
AW22_4119	COG3842	ATPase activity
AW22_4120	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AW22_4124	COG2851	Citrate transporter
AW22_4125	COG4565	transcriptional regulatory protein
AW22_4126	COG3290	protein histidine kinase activity
AW22_4128	COG2268	Band 7 protein
AW22_4129	COG1585	Membrane protein implicated in regulation of membrane protease activity
AW22_413	COG1609	Transcriptional regulator
AW22_4131	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AW22_4134	COG2766	serine protein kinase
AW22_4136	COG5001	Diguanylate cyclase
AW22_4136	COG1716	ATPase activity
AW22_4137	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AW22_4139	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AW22_414	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AW22_4141	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AW22_4142	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AW22_415	COG0095	Lipoate-protein ligase
AW22_4176	COG0735	belongs to the Fur family
AW22_4177	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AW22_418	COG1695	Transcriptional regulator
AW22_4181	COG4555	ABC transporter
AW22_4183	COG0070	glutamate synthase
AW22_4183	COG0067	glutamate synthase
AW22_4183	COG0069	glutamate synthase activity
AW22_4184	COG4129	membrane
AW22_4185	COG1132	(ABC) transporter
AW22_4190	COG1194	a g-specific adenine glycosylase
AW22_4191	COG1988	membrane-bound metal-dependent
AW22_4197	COG1090	epimerase
AW22_4198	COG1228	amidohydrolase
AW22_42	COG0628	permease
AW22_4202	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AW22_4205	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AW22_4205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AW22_4212	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AW22_4213	COG1263	PTS System
AW22_4213	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AW22_4214	COG2066	Belongs to the glutaminase family
AW22_4219	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AW22_422	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AW22_4225	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AW22_4229	COG0535	radical SAM domain protein
AW22_423	COG3872	metal-dependent enzyme
AW22_4231	COG0387	Pfam Sodium calcium exchanger
AW22_4232	COG3871	stress protein (general stress protein 26)
AW22_4235	COG0586	Pfam SNARE associated Golgi protein
AW22_4239	COG0697	spore germination
AW22_4240	COG2217	Heavy metal translocating P-type atpase
AW22_4241	COG1295	ribonuclease BN
AW22_4243	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AW22_4246	COG3853	Toxic anion resistance protein (TelA)
AW22_4248	COG0861	Integral membrane protein TerC family
AW22_4249	COG2310	stress, protein
AW22_4250	COG2310	stress, protein
AW22_4251	COG2310	stress, protein
AW22_4257	COG2270	Major facilitator Superfamily
AW22_426	COG0006	proline dipeptidase activity
AW22_4267	COG0488	(ABC) transporter
AW22_4269	COG1116	anion transmembrane transporter activity
AW22_4271	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AW22_4274	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AW22_4280	COG2190	(PTS) system
AW22_4280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AW22_4280	COG1263	PTS System
AW22_4281	COG0366	Alpha amylase catalytic
AW22_4282	COG0366	Alpha amylase catalytic
AW22_4283	COG0840	transmembrane signaling receptor activity
AW22_4284	COG0840	transmembrane signaling receptor activity
AW22_4286	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AW22_4287	COG0765	amino acid transport
AW22_4292	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AW22_4292	COG0723	plastoquinol--plastocyanin reductase activity
AW22_4293	COG2814	Major facilitator Superfamily
AW22_4294	COG3541	Predicted nucleotidyltransferase
AW22_4298	COG5002	protein histidine kinase activity
AW22_4304	COG0166	Belongs to the GPI family
AW22_4307	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AW22_4308	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AW22_4309	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AW22_431	COG3854	ATPases associated with a variety of cellular activities
AW22_4311	COG0235	Class ii aldolase
AW22_4313	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
AW22_4314	COG0450	alkyl hydroperoxide reductase
AW22_4317	COG1473	amidohydrolase
AW22_4323	COG4807	Protein conserved in bacteria
AW22_4324	COG5002	protein histidine kinase activity
AW22_4325	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AW22_4326	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AW22_4327	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AW22_4330	COG2309	aminopeptidase activity
AW22_4331	COG2076	Multidrug Resistance protein
AW22_4332	COG1012	belongs to the aldehyde dehydrogenase family
AW22_4334	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AW22_4335	COG0546	phosphoglycolate phosphatase activity
AW22_4336	COG1597	lipid kinase activity
AW22_4340	COG4682	membrane
AW22_4341	COG1846	Transcriptional regulator
AW22_4342	COG0003	Pfam Anion-transporting ATPase
AW22_4345	COG1464	Belongs to the NlpA lipoprotein family
AW22_4346	COG2011	ABC-type metal ion transport system permease component
AW22_4347	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AW22_4348	COG1335	isochorismatase
AW22_4352	COG4851	CamS sex pheromone cAM373 precursor
AW22_4354	COG0210	DNA helicase
AW22_4359	COG0151	Belongs to the GarS family
AW22_4361	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AW22_4363	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AW22_4366	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AW22_4368	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AW22_4369	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AW22_4370	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AW22_4376	COG0697	spore germination
AW22_4381	COG0745	RESPONSE REGULATOR receiver
AW22_4382	COG2205	protein histidine kinase activity
AW22_4395	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AW22_44	COG0372	Belongs to the citrate synthase family
AW22_440	COG0511	ligase activity, forming carbon-carbon bonds
AW22_4401	COG5002	protein histidine kinase activity
AW22_4403	COG2252	PERMEase
AW22_4406	COG5444	nuclease activity
AW22_4409	COG1266	CAAX protease self-immunity
AW22_441	COG0439	Biotin carboxylase
AW22_4412	COG0488	(ABC) transporter
AW22_4414	COG0456	acetyltransferase
AW22_4415	COG1214	PFAM Peptidase M22, glycoprotease
AW22_4416	COG0802	atpase or kinase
AW22_442	COG1302	Protein conserved in bacteria
AW22_4434	COG2183	response to ionizing radiation
AW22_4435	COG2337	Toxic component of a toxin-antitoxin (TA) module
AW22_4436	COG0864	Transcriptional regulator
AW22_4437	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AW22_4438	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AW22_4440	COG4294	response to UV
AW22_4441	COG0457	Tetratricopeptide repeat
AW22_4441	COG0705	Rhomboid family
AW22_4443	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AW22_4445	COG2814	Major facilitator Superfamily
AW22_4449	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AW22_4455	COG0561	phosphatase activity
AW22_4456	COG4608	Belongs to the ABC transporter superfamily
AW22_4457	COG0444	Belongs to the ABC transporter superfamily
AW22_4459	COG0601	transmembrane transport
AW22_4460	COG0747	negative chemotaxis
AW22_4463	COG0488	(ABC) transporter
AW22_4467	COG5298	Protein conserved in bacteria
AW22_4469	COG0084	hydrolase, TatD family'
AW22_447	COG0142	geranyltranstransferase activity
AW22_4472	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AW22_4474	COG1609	Transcriptional regulator
AW22_4476	COG0204	Acyl-transferase
AW22_4479	COG0697	spore germination
AW22_4483	COG1910	domain protein
AW22_4484	COG0725	ABC transporter, periplasmic molybdate-binding protein
AW22_4485	COG4149	molybdate abc transporter
AW22_4488	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AW22_4489	COG0656	L-ascorbic acid biosynthetic process
AW22_449	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AW22_4490	COG4166	transmembrane transport
AW22_4491	COG4166	transmembrane transport
AW22_4494	COG2207	Transcriptional regulator
AW22_4496	COG4166	transmembrane transport
AW22_4497	COG4608	Belongs to the ABC transporter superfamily
AW22_4498	COG0444	Belongs to the ABC transporter superfamily
AW22_4499	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AW22_45	COG0538	isocitrate dehydrogenase activity
AW22_4500	COG0601	transmembrane transport
AW22_4503	COG2814	Major facilitator Superfamily
AW22_4505	COG2271	Major facilitator Superfamily
AW22_4506	COG0277	FAD linked oxidase domain protein
AW22_4509	COG1464	Belongs to the NlpA lipoprotein family
AW22_451	COG0497	DNA recombination
AW22_4510	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AW22_4511	COG2011	ABC-type metal ion transport system permease component
AW22_4512	COG1028	Short-chain dehydrogenase reductase Sdr
AW22_452	COG0750	zinc metalloprotease
AW22_4520	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AW22_4528	COG4856	YbbR-like protein
AW22_4529	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AW22_453	COG0745	RESPONSE REGULATOR receiver
AW22_4546	COG0726	polysaccharide deacetylase
AW22_4547	COG2194	sulfuric ester hydrolase activity
AW22_4549	COG0489	protein tyrosine kinase activity
AW22_455	COG3093	addiction module antidote protein HigA
AW22_4550	COG0860	N-Acetylmuramoyl-L-alanine amidase
AW22_4554	COG0101	tRNA pseudouridine synthase activity
AW22_4555	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AW22_4556	COG1122	ATPase activity
AW22_456	COG0584	glycerophosphoryl diester phosphodiesterase
AW22_4562	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AW22_4564	COG0024	Methionine aminopeptidase
AW22_4566	COG0201	protein transport
AW22_4571	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AW22_458	COG3829	transcription factor binding
AW22_458	COG3290	protein histidine kinase activity
AW22_459	COG0280	phosphate acetyltransferase
AW22_4592	COG1358	cellular component organization or biogenesis
AW22_4595	COG2813	Specifically methylates the guanine in position
AW22_460	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AW22_4600	COG0250	Participates in transcription elongation, termination and antitermination
AW22_4601	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AW22_4603	COG3688	RNA-binding protein containing a PIN domain
AW22_4604	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AW22_4607	COG1045	serine acetyltransferase
AW22_4611	COG4956	integral membrane protein (PIN domain superfamily)
AW22_4613	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AW22_4614	COG0542	response to heat
AW22_4616	COG3880	PFAM UvrB UvrC protein
AW22_462	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AW22_463	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AW22_4636	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AW22_4637	COG1396	sequence-specific DNA binding
AW22_4638	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AW22_4639	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AW22_464	COG0022	dehydrogenase e1 component
AW22_4640	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AW22_4641	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AW22_4642	COG0512	Glutamine amidotransferase of anthranilate synthase
AW22_4643	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AW22_4644	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AW22_4647	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AW22_465	COG0508	dehydrogenase complex catalyzes the overall conversion of
AW22_4650	COG2208	phosphoserine phosphatase activity
AW22_4653	COG1098	S1 RNA binding domain
AW22_4657	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AW22_4658	COG3956	TIGRFAM MazG family protein
AW22_4659	COG2244	polysaccharide biosynthetic process
AW22_466	COG0772	Belongs to the SEDS family
AW22_4660	COG2002	toxin-antitoxin pair type II binding
AW22_4661	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AW22_4663	COG0193	aminoacyl-tRNA hydrolase activity
AW22_4664	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AW22_4667	COG0251	oxidation-reduction process
AW22_4668	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AW22_467	COG2816	NAD+ diphosphatase activity
AW22_4671	COG4466	Protein conserved in bacteria
AW22_4674	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AW22_4675	COG0084	hydrolase, TatD family'
AW22_4676	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AW22_4676	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AW22_4677	COG2002	toxin-antitoxin pair type II binding
AW22_4678	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AW22_4680	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AW22_4682	COG1774	PSP1 C-terminal conserved region
AW22_4683	COG0470	DNA polymerase III
AW22_4685	COG1982	Orn Lys Arg decarboxylase major
AW22_4697	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AW22_4698	COG0590	tRNA wobble adenosine to inosine editing
AW22_4699	COG1335	isochorismatase
AW22_470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AW22_4700	COG1428	Deoxynucleoside kinase
AW22_4701	COG1428	Deoxynucleoside kinase
AW22_4707	COG1686	Belongs to the peptidase S11 family
AW22_4708	COG0516	GMP reductase activity
AW22_4708	COG0517	IMP dehydrogenase activity
AW22_471	COG0765	amino acid transport
AW22_4716	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AW22_4717	COG0187	DNA topoisomerase II activity
AW22_4719	COG2501	S4 domain
AW22_472	COG1126	abc transporter atp-binding protein
AW22_4720	COG0592	DNA-directed DNA polymerase activity
AW22_4724	COG0706	membrane insertase activity
AW22_4725	COG1847	R3H domain protein
AW22_473	COG4129	membrane
AW22_4730	COG1192	Involved in chromosome partitioning
AW22_4731	COG1475	DNA binding
AW22_4733	COG0668	transmembrane transport
AW22_4734	COG4481	Protein conserved in bacteria
AW22_4735	COG0012	GTP binding
AW22_4737	COG0629	single-stranded DNA binding
AW22_4739	COG4241	membrane
AW22_474	COG1376	ErfK ybiS ycfS ynhG family protein
AW22_4740	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AW22_4742	COG0305	Participates in initiation and elongation during chromosome replication
AW22_4748	COG0745	RESPONSE REGULATOR receiver
AW22_4749	COG5002	protein histidine kinase activity
AW22_4750	COG4863	YycH protein
AW22_4752	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AW22_4753	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AW22_4757	COG1164	Oligoendopeptidase f
AW22_476	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AW22_4762	COG1272	protein, Hemolysin III
AW22_4763	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AW22_4767	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AW22_4768	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
AW22_4769	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AW22_477	COG2195	Cleaves the N-terminal amino acid of tripeptides
AW22_4770	COG2814	Major facilitator Superfamily
AW22_4771	COG3275	phosphorelay sensor kinase activity
AW22_4772	COG3279	Response regulator of the LytR AlgR family
AW22_4775	COG0628	permease
AW22_4776	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AW22_4776	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AW22_4777	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AW22_4778	COG1309	transcriptional regulator
AW22_4779	COG0463	Glycosyl transferase, family 2
AW22_478	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AW22_4783	COG0488	(ABC) transporter
AW22_4786	COG1607	acyl-coa hydrolase
AW22_4788	COG0840	transmembrane signaling receptor activity
AW22_4793	COG0477	Major facilitator Superfamily
AW22_4794	COG3279	Response regulator of the LytR AlgR family
AW22_4795	COG1966	Carbon starvation protein
AW22_4796	COG2879	small protein
AW22_4797	COG3706	GGDEF domain
AW22_4798	COG0351	phosphomethylpyrimidine kinase
AW22_4799	COG4585	Histidine kinase
AW22_4799	COG2203	Gaf domain
AW22_4800	COG2197	response regulator
AW22_4802	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AW22_4805	COG1011	Hydrolase
AW22_4808	COG0460	homoserine dehydrogenase
AW22_481	COG1760	l-serine dehydratase
AW22_4810	COG1609	Transcriptional regulator
AW22_4811	COG2755	lipolytic protein G-D-S-L family
AW22_4812	COG1131	(ABC) transporter
AW22_4813	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AW22_4815	COG2814	Major facilitator Superfamily
AW22_4816	COG0561	phosphatase activity
AW22_4817	COG2233	PERMEase
AW22_4818	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AW22_482	COG1760	l-serine dehydratase
AW22_4820	COG2363	Small membrane protein
AW22_4822	COG3773	Cell wall hydrolase
AW22_4825	COG0280	phosphate acetyltransferase
AW22_4826	COG0095	Lipoate-protein ligase
AW22_483	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AW22_4830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AW22_4831	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AW22_4832	COG1120	ATPase activity
AW22_4833	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AW22_4834	COG1078	dGTPase activity
AW22_4836	COG1994	Peptidase M50
AW22_4838	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AW22_4839	COG0584	glycerophosphoryl diester phosphodiesterase
AW22_484	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AW22_4840	COG0789	Transcriptional regulator
AW22_4841	COG2814	Major facilitator Superfamily
AW22_4842	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AW22_4843	COG0010	Belongs to the arginase family
AW22_4846	COG1619	proteins homologs of microcin C7 resistance protein MccF
AW22_4847	COG4506	Protein conserved in bacteria
AW22_4849	COG1595	DNA-templated transcription, initiation
AW22_485	COG0300	oxidoreductase activity
AW22_4853	COG2234	aminopeptidase activity
AW22_4855	COG0024	Methionine aminopeptidase
AW22_4856	COG1131	(ABC) transporter
AW22_4857	COG0842	Transport permease protein
AW22_4858	COG4585	Histidine kinase
AW22_4859	COG2197	response regulator
AW22_4863	COG3300	MHYT domain
AW22_4863	COG5001	Diguanylate cyclase
AW22_4865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AW22_4866	COG0247	lactate metabolic process
AW22_4866	COG2181	nitrate reductase activity
AW22_4867	COG0183	Belongs to the thiolase family
AW22_4868	COG1250	3-hydroxyacyl-CoA dehydrogenase
AW22_4869	COG1960	acyl-CoA dehydrogenase activity
AW22_4870	COG1960	acyl-CoA dehydrogenase activity
AW22_4874	COG4821	SIS domain
AW22_4877	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AW22_4878	COG1494	fructose-1,6-bisphosphatase
AW22_4879	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AW22_488	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AW22_4882	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AW22_4883	COG2890	protein-(glutamine-N5) methyltransferase activity
AW22_4886	COG0009	L-threonylcarbamoyladenylate synthase
AW22_4891	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AW22_4892	COG2259	Doxx family
AW22_4893	COG2190	(PTS) system
AW22_4895	COG0698	ribose 5-phosphate isomerase
AW22_490	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AW22_4901	COG0356	it plays a direct role in the translocation of protons across the membrane
AW22_4911	COG3300	MHYT domain
AW22_4911	COG5001	Diguanylate cyclase
AW22_4912	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AW22_4914	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AW22_4915	COG0649	NAD binding
AW22_4918	COG0839	Belongs to the complex I subunit 6 family
AW22_4920	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AW22_4921	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AW22_4922	COG1007	ATP synthesis coupled electron transport
AW22_4923	COG4836	Membrane
AW22_4925	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AW22_4926	COG2385	sporulation resulting in formation of a cellular spore
AW22_4927	COG3279	Response regulator of the LytR AlgR family
AW22_4930	COG0739	heme binding
AW22_4931	COG1609	Transcriptional regulator
AW22_4934	COG0489	protein tyrosine kinase activity
AW22_4935	COG3944	biosynthesis protein
AW22_4936	COG0489	protein tyrosine kinase activity
AW22_4937	COG4464	protein tyrosine phosphatase activity
AW22_4938	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AW22_4939	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AW22_494	COG1522	sequence-specific DNA binding
AW22_4940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AW22_4945	COG0438	transferase activity, transferring glycosyl groups
AW22_4947	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AW22_4948	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AW22_4948	COG0662	Cupin 2, conserved barrel domain protein
AW22_4950	COG1482	cell wall glycoprotein biosynthetic process
AW22_4953	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AW22_4954	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AW22_4954	COG3711	transcriptional antiterminator
AW22_4955	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AW22_4955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AW22_4955	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AW22_4956	COG1482	cell wall glycoprotein biosynthetic process
AW22_4957	COG0745	RESPONSE REGULATOR receiver
AW22_496	COG0737	Belongs to the 5'-nucleotidase family
AW22_4965	COG1136	(ABC) transporter
AW22_4966	COG0577	efflux transmembrane transporter activity
AW22_4969	COG1191	sigma factor activity
AW22_4975	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AW22_4976	COG4715	Zinc finger, swim domain protein
AW22_4981	COG3584	3D domain protein
AW22_4981	COG1388	LysM domain
AW22_4982	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AW22_4984	COG1215	transferase activity, transferring glycosyl groups
AW22_4986	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AW22_4987	COG0791	NLP P60 protein
AW22_4987	COG1388	LysM domain
AW22_4989	COG1368	sulfuric ester hydrolase activity
AW22_499	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AW22_4991	COG2389	metal-binding protein
AW22_4994	COG1620	l-lactate permease
AW22_4996	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AW22_4997	COG1294	oxidase, subunit
AW22_4998	COG1271	oxidase subunit
AW22_50	COG0745	RESPONSE REGULATOR receiver
AW22_5000	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AW22_5001	COG0583	DNA-binding transcription factor activity
AW22_5002	COG1511	domain protein
AW22_5006	COG0346	lactoylglutathione lyase activity
AW22_5008	COG1301	dicarboxylic acid transport
AW22_5009	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AW22_5011	COG1447	Phosphotransferase system cellobiose-specific component IIA
AW22_5015	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AW22_5017	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AW22_5018	COG1447	Phosphotransferase system cellobiose-specific component IIA
AW22_5019	COG1486	melibiose metabolic process
AW22_502	COG2226	methyltransferase
AW22_502	COG1073	alpha beta
AW22_5023	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AW22_5023	COG3933	PFAM sigma-54 factor interaction domain-containing protein
AW22_5025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AW22_5026	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AW22_5027	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AW22_5028	COG1316	TRANSCRIPTIONal
AW22_5029	COG1739	Uncharacterized protein family UPF0029
AW22_503	COG4106	trans-aconitate 2-methyltransferase activity
AW22_5030	COG1307	EDD domain protein, DegV family
AW22_5031	COG1733	regulation of RNA biosynthetic process
AW22_5032	COG0791	NLP P60 protein
AW22_5032	COG1388	LysM domain
AW22_5033	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AW22_5034	COG1040	competence protein
AW22_5035	COG1278	Cold shock
AW22_5036	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AW22_5038	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AW22_5040	COG2884	Cell division ATP-binding protein ftsE
AW22_5041	COG2177	Part of the ABC transporter FtsEX involved in
AW22_5042	COG3409	Peptidoglycan-binding domain 1 protein
AW22_5042	COG0793	Belongs to the peptidase S41A family
AW22_5043	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AW22_5044	COG1132	(ABC) transporter
AW22_5046	COG0488	(ABC) transporter
AW22_5047	COG0655	NAD(P)H dehydrogenase (quinone) activity
AW22_5049	COG0583	DNA-binding transcription factor activity
AW22_5050	COG2855	membrane
AW22_5055	COG0789	Transcriptional regulator
AW22_5058	COG0556	nucleotide-excision repair
AW22_5059	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AW22_5061	COG1950	PFAM Membrane protein of
AW22_5065	COG0110	maltose O-acetyltransferase activity
AW22_5066	COG0457	Tetratricopeptide repeat
AW22_5067	COG0492	ferredoxin-NADP+ reductase activity
AW22_5069	COG1051	belongs to the nudix hydrolase family
AW22_5071	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AW22_5073	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AW22_5075	COG2323	membrane
AW22_5078	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AW22_508	COG0307	riboflavin synthase, alpha
AW22_5083	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AW22_5086	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AW22_509	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AW22_509	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AW22_5093	COG1346	cytolysis
AW22_5094	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AW22_5095	COG1647	Serine aminopeptidase, S33
AW22_5096	COG0557	exoribonuclease II activity
AW22_51	COG5002	protein histidine kinase activity
AW22_5106	COG3223	Belongs to the PsiE family
AW22_5107	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AW22_5108	COG0488	(ABC) transporter
AW22_5113	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AW22_5115	COG3290	protein histidine kinase activity
AW22_5115	COG0840	transmembrane signaling receptor activity
AW22_5117	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AW22_5118	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AW22_5119	COG1252	NADH dehydrogenase
AW22_512	COG1073	alpha beta
AW22_5121	COG1733	regulation of RNA biosynthetic process
AW22_5122	COG2814	Major facilitator Superfamily
AW22_5123	COG0656	L-ascorbic acid biosynthetic process
AW22_5126	COG2910	NAD(P)H-binding
AW22_5127	COG1115	amino acid carrier protein
AW22_5128	COG1115	amino acid carrier protein
AW22_5129	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AW22_513	COG0456	acetyltransferase
AW22_5130	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AW22_5134	COG1611	Belongs to the LOG family
AW22_5137	COG0783	Belongs to the Dps family
AW22_5138	COG1115	amino acid carrier protein
AW22_5139	COG0490	domain, Protein
AW22_514	COG1609	Transcriptional regulator
AW22_5140	COG0475	glutathione-regulated potassium exporter activity
AW22_5143	COG1741	Belongs to the pirin family
AW22_5144	COG3227	Zinc metalloprotease (Elastase)
AW22_5145	COG2151	metal-sulfur cluster biosynthetic enzyme
AW22_5146	COG0840	transmembrane signaling receptor activity
AW22_515	COG2056	Na+-H+ antiporter family
AW22_5152	COG5002	protein histidine kinase activity
AW22_5153	COG0745	RESPONSE REGULATOR receiver
AW22_5154	COG1376	ErfK ybiS ycfS ynhG family protein
AW22_5156	COG0586	Pfam SNARE associated Golgi protein
AW22_516	COG0596	Alpha beta hydrolase
AW22_5164	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AW22_5166	COG0706	membrane insertase activity
AW22_5169	COG0531	amino acid
AW22_5170	COG2814	Major facilitator Superfamily
AW22_5174	COG0840	transmembrane signaling receptor activity
AW22_5175	COG0011	TIGRFAM Protein of
AW22_5178	COG1686	Belongs to the peptidase S11 family
AW22_518	COG4085	toxin activity
AW22_518	COG1525	nuclease
AW22_518	COG0737	Belongs to the 5'-nucleotidase family
AW22_5180	COG1024	Enoyl-CoA hydratase
AW22_5180	COG1250	3-hydroxyacyl-CoA dehydrogenase
AW22_5181	COG0183	Belongs to the thiolase family
AW22_5182	COG1960	acyl-CoA dehydrogenase activity
AW22_5187	COG4555	ABC transporter
AW22_5190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AW22_5191	COG1309	transcriptional regulator
AW22_5196	COG0039	L-malate dehydrogenase activity
AW22_52	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AW22_52	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AW22_520	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AW22_520	COG0456	acetyltransferase
AW22_5205	COG1393	Belongs to the ArsC family
AW22_5207	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AW22_5208	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AW22_521	COG0656	L-ascorbic acid biosynthetic process
AW22_5211	COG2011	ABC-type metal ion transport system permease component
AW22_5212	COG1464	Belongs to the NlpA lipoprotein family
AW22_5213	COG1464	Belongs to the NlpA lipoprotein family
AW22_5214	COG0396	ATPase activity
AW22_5215	COG0719	Fe-S assembly protein
AW22_5216	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AW22_5217	COG0822	iron-sulfur transferase activity
AW22_5218	COG0719	Fe-S assembly protein
AW22_522	COG0667	Aldo Keto reductase
AW22_5220	COG1695	Transcriptional regulator
AW22_5221	COG0737	Belongs to the 5'-nucleotidase family
AW22_5222	COG3377	Domain of unknown function (DUF1805)
AW22_5224	COG0739	heme binding
AW22_5229	COG4377	Putative membrane peptidase family (DUF2324)
AW22_5230	COG0789	Transcriptional regulator
AW22_5232	COG4470	Protein conserved in bacteria
AW22_5235	COG1494	fructose-1,6-bisphosphatase
AW22_5236	COG2445	Protein of unknown function DUF86
AW22_5238	COG0647	UMP catabolic process
AW22_5239	COG2249	NAD(P)H dehydrogenase (quinone) activity
AW22_5240	COG1136	(ABC) transporter
AW22_5240	COG0577	efflux transmembrane transporter activity
AW22_5243	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AW22_5244	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AW22_5246	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AW22_5247	COG4837	Protein of unknown function (DUF1462)
AW22_5251	COG2824	Alkylphosphonate utilization operon protein PhnA
AW22_5252	COG0390	transport system, permease component
AW22_5253	COG2274	protein secretion by the type I secretion system
AW22_5254	COG1252	NADH dehydrogenase
AW22_5257	COG0316	Belongs to the HesB IscA family
AW22_526	COG1300	Membrane
AW22_5260	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AW22_527	COG0735	belongs to the Fur family
AW22_529	COG4974	Belongs to the 'phage' integrase family
AW22_53	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AW22_5306	COG5632	N-Acetylmuramoyl-L-alanine amidase
AW22_5311	COG1683	Conserved Protein
AW22_5314	COG3708	Transcriptional regulator
AW22_5317	COG1252	NADH dehydrogenase
AW22_5320	COG3584	3D domain protein
AW22_5323	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AW22_5324	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AW22_5325	COG1268	BioY protein
AW22_5327	COG2050	protein possibly involved in aromatic compounds catabolism
AW22_5328	COG0423	glycine-tRNA ligase activity
AW22_5331	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AW22_5332	COG5018	Exonuclease
AW22_5336	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AW22_5338	COG2267	carboxylic ester hydrolase activity
AW22_5339	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AW22_534	COG0598	Magnesium transport protein CorA
AW22_5340	COG1522	sequence-specific DNA binding
AW22_5341	COG0436	Aminotransferase
AW22_5342	COG1098	S1 RNA binding domain
AW22_5343	COG2155	Conserved Protein
AW22_5345	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AW22_5347	COG1285	pathogenesis
AW22_5355	COG0544	peptidyl-prolyl cis-trans isomerase activity
AW22_537	COG1846	Transcriptional regulator
AW22_5374	COG0039	L-malate dehydrogenase activity
AW22_5375	COG1404	Belongs to the peptidase S8 family
AW22_5379	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AW22_5381	COG0058	SHG alpha-glucan phosphorylase activity
AW22_5385	COG1278	Cold shock
AW22_5386	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AW22_5387	COG1575	Belongs to the MenA family. Type 1 subfamily
AW22_5388	COG1169	isochorismate synthase
AW22_5390	COG0596	Alpha beta hydrolase
AW22_5391	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AW22_5393	COG4948	Mandelate Racemase Muconate Lactonizing
AW22_5397	COG3964	amidohydrolase
AW22_54	COG1971	Probably functions as a manganese efflux pump
AW22_540	COG1131	(ABC) transporter
AW22_5404	COG0577	efflux transmembrane transporter activity
AW22_5405	COG1136	(ABC) transporter
AW22_5406	COG0577	efflux transmembrane transporter activity
AW22_5407	COG0577	efflux transmembrane transporter activity
AW22_5408	COG2205	protein histidine kinase activity
AW22_5409	COG0745	RESPONSE REGULATOR receiver
AW22_541	COG1725	Transcriptional regulator
AW22_5410	COG2207	Transcriptional regulator
AW22_5410	COG3708	Transcriptional regulator
AW22_5411	COG1136	(ABC) transporter
AW22_5412	COG0577	efflux transmembrane transporter activity
AW22_5414	COG0586	Pfam SNARE associated Golgi protein
AW22_5419	COG1597	lipid kinase activity
AW22_542	COG1686	Belongs to the peptidase S11 family
AW22_5425	COG0745	RESPONSE REGULATOR receiver
AW22_5426	COG5002	protein histidine kinase activity
AW22_5427	COG3859	Proton-coupled thiamine transporter YuaJ
AW22_5441	COG1842	Phage shock protein A
AW22_5446	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AW22_5450	COG1294	oxidase, subunit
AW22_5451	COG1271	oxidase subunit
AW22_5453	COG0288	reversible hydration of carbon dioxide
AW22_5458	COG0494	nUDIX hydrolase
AW22_546	COG0733	neurotransmitter:sodium symporter activity
AW22_5460	COG0546	phosphoglycolate phosphatase activity
AW22_5463	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AW22_5464	COG1116	anion transmembrane transporter activity
AW22_5465	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AW22_5468	COG1368	sulfuric ester hydrolase activity
AW22_5469	COG2267	carboxylic ester hydrolase activity
AW22_5470	COG4191	Histidine kinase
AW22_5471	COG5002	protein histidine kinase activity
AW22_5473	COG1349	DNA-binding transcription factor activity
AW22_5474	COG0546	phosphoglycolate phosphatase activity
AW22_5486	COG0521	Mo-molybdopterin cofactor biosynthetic process
AW22_5488	COG0438	transferase activity, transferring glycosyl groups
AW22_5489	COG0671	phosphoesterase, PA-phosphatase related
AW22_5490	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AW22_5491	COG2267	carboxylic ester hydrolase activity
AW22_5496	COG5504	Zn-dependent protease
AW22_5498	COG1794	racemase activity, acting on amino acids and derivatives
AW22_55	COG0237	dephospho-CoA kinase activity
AW22_5501	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AW22_5502	COG1242	4 iron, 4 sulfur cluster binding
AW22_5506	COG1136	(ABC) transporter
AW22_5509	COG0582	viral genome integration into host DNA
AW22_551	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AW22_5510	COG0490	domain, Protein
AW22_5511	COG0475	glutathione-regulated potassium exporter activity
AW22_5512	COG2814	Major facilitator Superfamily
AW22_5520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AW22_5522	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AW22_5526	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AW22_5527	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AW22_5529	COG0303	'Molybdopterin
AW22_5530	COG1763	Mo-molybdopterin cofactor biosynthetic process
AW22_5531	COG0314	molybdopterin synthase activity
AW22_5536	COG1329	Transcriptional regulator
AW22_554	COG0697	spore germination
AW22_5540	COG3832	glyoxalase III activity
AW22_5542	COG2814	Major facilitator Superfamily
AW22_5543	COG2081	HI0933 family
AW22_5544	COG2244	polysaccharide biosynthetic process
AW22_5545	COG1187	pseudouridine synthase activity
AW22_5546	COG1349	DNA-binding transcription factor activity
AW22_5547	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AW22_5549	COG1523	belongs to the glycosyl hydrolase 13 family
AW22_555	COG0561	phosphatase activity
AW22_5550	COG0510	thiamine kinase activity
AW22_5553	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AW22_5555	COG1363	Peptidase, m42
AW22_5556	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AW22_5557	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AW22_5559	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AW22_556	COG4086	secreted protein
AW22_5561	COG1674	ftsk spoiiie
AW22_5565	COG1695	Transcriptional regulator
AW22_5566	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AW22_5569	COG1136	(ABC) transporter
AW22_557	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AW22_5570	COG0577	efflux transmembrane transporter activity
AW22_5573	COG2309	aminopeptidase activity
AW22_5575	COG3118	belongs to the thioredoxin family
AW22_5576	COG4851	CamS sex pheromone cAM373 precursor
AW22_5577	COG1609	Transcriptional regulator
AW22_558	COG0456	acetyltransferase
AW22_5584	COG0666	response to abiotic stimulus
AW22_5585	COG5002	protein histidine kinase activity
AW22_5586	COG0745	RESPONSE REGULATOR receiver
AW22_5589	COG0123	including yeast histone deacetylase and acetoin utilization protein
AW22_559	COG1547	Domain of unknown function (DUF309)
AW22_5590	COG0517	IMP dehydrogenase activity
AW22_5591	COG0454	-acetyltransferase
AW22_5592	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AW22_5594	COG1595	DNA-templated transcription, initiation
AW22_56	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AW22_5600	COG0626	cystathionine gamma-synthase activity
AW22_5601	COG1956	GAF domain-containing protein
AW22_5602	COG1309	transcriptional regulator
AW22_5603	COG1309	transcriptional regulator
AW22_5604	COG0697	spore germination
AW22_5605	COG0583	DNA-binding transcription factor activity
AW22_5607	COG1104	cysteine desulfurase activity
AW22_5610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AW22_5612	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AW22_5613	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AW22_5615	COG3874	Sporulation protein YtfJ
AW22_5616	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AW22_5617	COG0827	DNA restriction-modification system
AW22_5618	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AW22_564	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AW22_5659	COG3708	Transcriptional regulator
AW22_5659	COG2207	Transcriptional regulator
AW22_5665	COG2311	Membrane
AW22_5671	COG0776	regulation of translation
AW22_568	COG3711	transcriptional antiterminator
AW22_5682	COG2002	toxin-antitoxin pair type II binding
AW22_5685	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AW22_569	COG2190	(PTS) system
AW22_569	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AW22_569	COG1263	PTS System
AW22_5694	COG4166	transmembrane transport
AW22_5697	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AW22_57	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AW22_5713	COG4974	Belongs to the 'phage' integrase family
AW22_5720	COG2192	nodulation
AW22_5724	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AW22_5730	COG0457	Tetratricopeptide repeat
AW22_5732	COG1923	regulation of RNA biosynthetic process
AW22_574	COG0778	Nitroreductase
AW22_575	COG3706	GGDEF domain
AW22_576	COG2084	Dehydrogenase
AW22_5790	COG3344	reverse transcriptase
AW22_5791	COG1674	ftsk spoiiie
AW22_5825	COG0640	Transcriptional regulator
AW22_5827	COG2072	flavoprotein involved in K transport
AW22_5829	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AW22_583	COG0436	Aminotransferase
AW22_5830	COG0589	response to stress
AW22_5831	COG0659	secondary active sulfate transmembrane transporter activity
AW22_5832	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AW22_5835	COG0659	secondary active sulfate transmembrane transporter activity
AW22_5838	COG2824	Alkylphosphonate utilization operon protein PhnA
AW22_584	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AW22_5845	COG0640	Transcriptional regulator
AW22_5846	COG0798	PFAM Bile acid sodium symporter
AW22_588	COG1028	Short-chain dehydrogenase reductase Sdr
AW22_589	COG1695	Transcriptional regulator
AW22_59	COG3611	Membrane attachment protein
AW22_595	COG0183	Belongs to the thiolase family
AW22_60	COG1484	DNA-dependent DNA replication
AW22_603	COG3842	ATPase activity
AW22_604	COG0366	Alpha amylase catalytic
AW22_606	COG2182	Extracellular solute-binding protein
AW22_607	COG1175	transmembrane transport
AW22_608	COG3833	ABC-type maltose transport systems, permease component
AW22_609	COG1609	Transcriptional regulator
AW22_610	COG0436	Aminotransferase
AW22_612	COG2205	protein histidine kinase activity
AW22_614	COG3209	COG3209 Rhs family protein
AW22_618	COG2814	Major facilitator Superfamily
AW22_62	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AW22_625	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AW22_627	COG1408	metallophosphoesterase
AW22_628	COG1028	Short-chain dehydrogenase reductase Sdr
AW22_629	COG2200	EAL domain
AW22_63	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AW22_632	COG4703	Protein of unknown function (DUF1797)
AW22_634	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
AW22_636	COG0517	IMP dehydrogenase activity
AW22_637	COG0583	DNA-binding transcription factor activity
AW22_641	COG0569	domain protein
AW22_642	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AW22_644	COG0561	phosphatase activity
AW22_645	COG0242	peptide deformylase activity
AW22_647	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AW22_648	COG0022	dehydrogenase e1 component
AW22_657	COG1982	Orn Lys Arg decarboxylase major
AW22_661	COG0483	inositol monophosphate 1-phosphatase activity
AW22_666	COG4896	Protein conserved in bacteria
AW22_668	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AW22_669	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AW22_67	COG1363	Peptidase, m42
AW22_671	COG0772	Belongs to the SEDS family
AW22_672	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AW22_679	COG3336	cytochrome c oxidase
AW22_68	COG1309	transcriptional regulator
AW22_682	COG2340	Cysteine-rich secretory protein family
AW22_685	COG0406	alpha-ribazole phosphatase activity
AW22_686	COG3679	Belongs to the UPF0342 family
AW22_689	COG0742	ribosomal rna small subunit methyltransferase
AW22_69	COG1566	PFAM secretion protein HlyD family protein
AW22_690	COG3314	Sporulation integral membrane protein YlbJ
AW22_692	COG1752	Esterase of the alpha-beta hydrolase superfamily
AW22_693	COG3480	Lon protease (S16) C-terminal proteolytic domain
AW22_695	COG0582	viral genome integration into host DNA
AW22_698	COG1396	sequence-specific DNA binding
AW22_70	COG2814	Major facilitator Superfamily
AW22_702	COG1396	sequence-specific DNA binding
AW22_708	COG1484	DNA-dependent DNA replication
AW22_724	COG0582	viral genome integration into host DNA
AW22_732	COG4626	Terminase
AW22_732	COG1802	Transcriptional regulator
AW22_735	COG0740	serine-type endopeptidase activity
AW22_749	COG5632	N-Acetylmuramoyl-L-alanine amidase
AW22_751	COG3708	Transcriptional regulator
AW22_751	COG2207	Transcriptional regulator
AW22_757	COG1399	metal-binding, possibly nucleic acid-binding protein
AW22_761	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AW22_764	COG4839	cell division protein FtsL
AW22_766	COG0768	penicillin binding
AW22_767	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AW22_77	COG1418	mRNA catabolic process
AW22_770	COG0772	Belongs to the SEDS family
AW22_771	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AW22_772	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AW22_773	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AW22_774	COG0849	cell division
AW22_775	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AW22_777	COG1191	sigma factor activity
AW22_778	COG1191	sigma factor activity
AW22_779	COG1873	PFAM PRC-barrel domain
AW22_781	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AW22_783	COG0762	integral membrane protein
AW22_784	COG2302	S4 RNA-binding domain
AW22_785	COG3599	regulation of cell shape
AW22_789	COG0564	pseudouridine synthase activity
AW22_79	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AW22_794	COG0505	Belongs to the CarA family
AW22_801	COG3069	C4-dicarboxylate transmembrane transporter activity
AW22_805	COG0006	proline dipeptidase activity
AW22_808	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AW22_809	COG1561	YicC-like family, N-terminal region
AW22_81	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AW22_81	COG0072	phenylalanine-tRNA ligase activity
AW22_811	COG0194	GDP metabolic process
AW22_813	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AW22_814	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AW22_815	COG0242	peptide deformylase activity
AW22_817	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AW22_817	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AW22_819	COG0631	protein serine/threonine phosphatase activity
AW22_82	COG0017	Asparaginyl-tRNA synthetase
AW22_820	COG2815	serine threonine protein kinase
AW22_820	COG0515	serine threonine protein kinase
AW22_821	COG1162	GTPase activity
AW22_822	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AW22_823	COG1564	THIamine pyrophosphokinase
AW22_825	COG1302	Protein conserved in bacteria
AW22_826	COG1461	Dihydroxyacetone kinase
AW22_827	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AW22_830	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AW22_831	COG1028	Short-chain dehydrogenase reductase Sdr
AW22_834	COG1196	nuclear chromosome segregation
AW22_835	COG0552	protein localization to endoplasmic reticulum
AW22_837	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AW22_839	COG1837	Belongs to the UPF0109 family
AW22_847	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AW22_848	COG0758	DNA mediated transformation
AW22_849	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AW22_851	COG4974	Belongs to the 'phage' integrase family
AW22_857	COG0528	UMP kinase activity
AW22_860	COG4589	Belongs to the CDS family
AW22_861	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AW22_862	COG0750	zinc metalloprotease
AW22_869	COG0195	Participates in both transcription termination and antitermination
AW22_870	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AW22_871	COG1358	cellular component organization or biogenesis
AW22_873	COG1550	Protein conserved in bacteria
AW22_876	COG0196	riboflavin kinase activity
AW22_879	COG0726	polysaccharide deacetylase
AW22_88	COG1286	toxin biosynthetic process
AW22_880	COG0612	Peptidase, M16
AW22_881	COG1873	PFAM PRC-barrel domain
AW22_882	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AW22_883	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AW22_884	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AW22_885	COG0527	aspartate kinase activity
AW22_887	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AW22_888	COG0740	serine-type endopeptidase activity
AW22_89	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AW22_89	COG1796	DNA polymerase
AW22_890	COG1674	ftsk spoiiie
AW22_891	COG2188	Transcriptional regulator
AW22_896	COG0612	Peptidase, M16
AW22_897	COG0612	Peptidase, M16
AW22_898	COG0300	oxidoreductase activity
AW22_9	COG0589	response to stress
AW22_901	COG1426	Protein conserved in bacteria
AW22_902	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AW22_907	COG1692	metallophosphoesterase
AW22_908	COG2359	stage V sporulation protein S
AW22_910	COG0674	pyruvate-flavodoxin oxidoreductase activity
AW22_910	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AW22_911	COG1013	pyruvate-flavodoxin oxidoreductase activity
AW22_913	COG4550	Control of competence regulator ComK, YlbF/YmcA
AW22_917	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
AW22_919	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AW22_92	COG1187	pseudouridine synthase activity
AW22_920	COG1368	sulfuric ester hydrolase activity
AW22_922	COG3773	Cell wall hydrolase
AW22_923	COG1404	Belongs to the peptidase S8 family
AW22_926	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AW22_93	COG1114	Component of the transport system for branched-chain amino acids
AW22_932	COG1086	Polysaccharide biosynthesis protein
AW22_936	COG5001	Diguanylate cyclase
AW22_936	COG3300	MHYT domain
AW22_937	COG0346	lactoylglutathione lyase activity
AW22_938	COG2267	carboxylic ester hydrolase activity
AW22_94	COG5386	Cell surface protein
AW22_941	COG2364	Membrane
AW22_943	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AW22_944	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AW22_945	COG2169	Transcriptional regulator
AW22_946	COG0708	Exodeoxyribonuclease III
AW22_947	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AW22_948	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AW22_949	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AW22_95	COG5386	Cell surface protein
AW22_950	COG1120	ATPase activity
AW22_951	COG2819	hydrolase of the alpha beta superfamily
AW22_954	COG1937	Protein conserved in bacteria
AW22_955	COG2608	mercury ion transmembrane transporter activity
AW22_956	COG2217	Heavy metal translocating P-type atpase
AW22_958	COG2116	formate transmembrane transporter activity
AW22_959	COG1408	metallophosphoesterase
AW22_962	COG1113	amino acid transport
AW22_965	COG2322	membrane
AW22_966	COG1979	alcohol dehydrogenase
AW22_967	COG1349	DNA-binding transcription factor activity
AW22_968	COG1105	Belongs to the carbohydrate kinase PfkB family
AW22_969	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AW22_969	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AW22_969	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AW22_970	COG1388	LysM domain
AW22_970	COG3584	3D domain protein
AW22_976	COG0464	growth
AW22_978	COG2860	membrane
AW22_979	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AW22_98	COG1120	ATPase activity
AW22_980	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AW22_981	COG0789	Transcriptional regulator
AW22_982	COG0174	glutamine synthetase
AW22_983	COG1695	Transcriptional regulator
AW22_987	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AW22_989	COG0737	Belongs to the 5'-nucleotidase family
AW22_99	COG4509	Sortase family
AW22_992	COG3639	organic phosphonate transmembrane transporter activity