locus-tag	class	description
M6D84_00010	COG0592	DNA-directed DNA polymerase activity
M6D84_00015	COG2501	S4 domain
M6D84_00025	COG0187	DNA topoisomerase II activity
M6D84_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M6D84_00065	COG0516	GMP reductase activity
M6D84_00065	COG0517	IMP dehydrogenase activity
M6D84_00070	COG1686	Belongs to the peptidase S11 family
M6D84_00100	COG1428	Deoxynucleoside kinase
M6D84_00105	COG1428	Deoxynucleoside kinase
M6D84_00110	COG1335	isochorismatase
M6D84_00115	COG0590	tRNA wobble adenosine to inosine editing
M6D84_00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M6D84_00180	COG1982	Orn Lys Arg decarboxylase major
M6D84_00190	COG0470	DNA polymerase III
M6D84_00195	COG1774	PSP1 C-terminal conserved region
M6D84_00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M6D84_00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M6D84_00220	COG2002	toxin-antitoxin pair type II binding
M6D84_00230	COG0084	hydrolase, TatD family'
M6D84_00250	COG4466	Protein conserved in bacteria
M6D84_00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M6D84_00270	COG0251	oxidation-reduction process
M6D84_00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M6D84_00305	COG2002	toxin-antitoxin pair type II binding
M6D84_00310	COG2244	polysaccharide biosynthetic process
M6D84_00315	COG3956	TIGRFAM MazG family protein
M6D84_00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M6D84_00340	COG1098	S1 RNA binding domain
M6D84_00355	COG2208	phosphoserine phosphatase activity
M6D84_00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M6D84_00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M6D84_00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M6D84_00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M6D84_00395	COG0512	Glutamine amidotransferase of anthranilate synthase
M6D84_00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M6D84_00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M6D84_00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M6D84_00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M6D84_00420	COG1396	sequence-specific DNA binding
M6D84_00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M6D84_00515	COG3880	PFAM UvrB UvrC protein
M6D84_00525	COG0542	response to heat
M6D84_00530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M6D84_00540	COG4956	integral membrane protein (PIN domain superfamily)
M6D84_00560	COG1045	serine acetyltransferase
M6D84_00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M6D84_00580	COG3688	RNA-binding protein containing a PIN domain
M6D84_00595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M6D84_00600	COG0250	Participates in transcription elongation, termination and antitermination
M6D84_00605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M6D84_00625	COG2813	Specifically methylates the guanine in position
M6D84_00640	COG1358	cellular component organization or biogenesis
M6D84_00645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M6D84_00710	COG0255	Belongs to the universal ribosomal protein uL29 family
M6D84_00770	COG0201	protein transport
M6D84_00780	COG0024	Methionine aminopeptidase
M6D84_00790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M6D84_00825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M6D84_00850	COG0860	N-Acetylmuramoyl-L-alanine amidase
M6D84_00855	COG0489	protein tyrosine kinase activity
M6D84_00865	COG2194	sulfuric ester hydrolase activity
M6D84_00870	COG0726	polysaccharide deacetylase
M6D84_00950	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M6D84_00955	COG4856	YbbR-like protein
M6D84_01005	COG1028	Short-chain dehydrogenase reductase Sdr
M6D84_01010	COG2011	ABC-type metal ion transport system permease component
M6D84_01015	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M6D84_01020	COG1464	Belongs to the NlpA lipoprotein family
M6D84_01025	COG0604	alcohol dehydrogenase
M6D84_01035	COG0277	FAD linked oxidase domain protein
M6D84_01040	COG2271	Major facilitator Superfamily
M6D84_01050	COG2814	Major facilitator Superfamily
M6D84_01065	COG0601	transmembrane transport
M6D84_01070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M6D84_01075	COG0444	Belongs to the ABC transporter superfamily
M6D84_01080	COG4608	Belongs to the ABC transporter superfamily
M6D84_01085	COG4166	transmembrane transport
M6D84_01095	COG2207	Transcriptional regulator
M6D84_01110	COG4166	transmembrane transport
M6D84_01115	COG4166	transmembrane transport
M6D84_01120	COG0656	L-ascorbic acid biosynthetic process
M6D84_01135	COG4149	molybdate abc transporter
M6D84_01140	COG0725	ABC transporter, periplasmic molybdate-binding protein
M6D84_01145	COG1910	domain protein
M6D84_01160	COG0697	spore germination
M6D84_01175	COG0204	Acyl-transferase
M6D84_01185	COG1609	Transcriptional regulator
M6D84_01195	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M6D84_01210	COG5298	Protein conserved in bacteria
M6D84_01235	COG0488	(ABC) transporter
M6D84_01245	COG0747	negative chemotaxis
M6D84_01250	COG0601	transmembrane transport
M6D84_01255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M6D84_01260	COG0444	Belongs to the ABC transporter superfamily
M6D84_01265	COG4608	Belongs to the ABC transporter superfamily
M6D84_01270	COG0561	phosphatase activity
M6D84_01300	COG3185	4-Hydroxyphenylpyruvate dioxygenase
M6D84_01305	COG0179	Fumarylacetoacetate (FAA) hydrolase
M6D84_01315	COG0531	amino acid
M6D84_01320	COG2814	Major facilitator Superfamily
M6D84_01330	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M6D84_01340	COG4294	response to UV
M6D84_01345	COG0705	Rhomboid family
M6D84_01355	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M6D84_01360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M6D84_01365	COG0864	Transcriptional regulator
M6D84_01370	COG2337	Toxic component of a toxin-antitoxin (TA) module
M6D84_01375	COG2183	response to ionizing radiation
M6D84_01475	COG0802	atpase or kinase
M6D84_01480	COG1214	PFAM Peptidase M22, glycoprotease
M6D84_01485	COG0456	acetyltransferase
M6D84_01495	COG0488	(ABC) transporter
M6D84_01510	COG1266	CAAX protease self-immunity
M6D84_01530	COG2252	PERMEase
M6D84_01540	COG5002	protein histidine kinase activity
M6D84_01565	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M6D84_01605	COG2205	protein histidine kinase activity
M6D84_01610	COG0745	RESPONSE REGULATOR receiver
M6D84_01635	COG2226	methyltransferase
M6D84_01645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M6D84_01655	COG0463	Glycosyl transferase, family 2
M6D84_01655	COG1216	Glycosyl transferase, family 2
M6D84_01675	COG0697	spore germination
M6D84_01705	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M6D84_01710	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M6D84_01715	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M6D84_01725	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M6D84_01740	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M6D84_01750	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M6D84_01760	COG0151	Belongs to the GarS family
M6D84_01785	COG0210	DNA helicase
M6D84_01795	COG4851	CamS sex pheromone cAM373 precursor
M6D84_01810	COG1335	isochorismatase
M6D84_01820	COG2011	ABC-type metal ion transport system permease component
M6D84_01825	COG1464	Belongs to the NlpA lipoprotein family
M6D84_01840	COG0003	Pfam Anion-transporting ATPase
M6D84_01845	COG1846	Transcriptional regulator
M6D84_01850	COG4682	membrane
M6D84_01870	COG1597	lipid kinase activity
M6D84_01880	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M6D84_01890	COG1012	belongs to the aldehyde dehydrogenase family
M6D84_01895	COG2076	Multidrug Resistance protein
M6D84_01905	COG2309	aminopeptidase activity
M6D84_01925	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M6D84_01935	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M6D84_01940	COG4807	Protein conserved in bacteria
M6D84_01965	COG1757	Na H antiporter
M6D84_01970	COG1473	amidohydrolase
M6D84_01985	COG0450	alkyl hydroperoxide reductase
M6D84_02005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M6D84_02010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M6D84_02015	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M6D84_02020	COG0492	ferredoxin-NADP+ reductase activity
M6D84_02030	COG0166	Belongs to the GPI family
M6D84_02055	COG5002	protein histidine kinase activity
M6D84_02075	COG3541	Predicted nucleotidyltransferase
M6D84_02080	COG2814	Major facilitator Superfamily
M6D84_02085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M6D84_02085	COG0723	plastoquinol--plastocyanin reductase activity
M6D84_02095	COG0765	amino acid transport
M6D84_02100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M6D84_02110	COG0840	transmembrane signaling receptor activity
M6D84_02135	COG0549	Belongs to the carbamate kinase family
M6D84_02140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M6D84_02150	COG0277	FAD linked oxidase domain protein
M6D84_02155	COG0366	Alpha amylase catalytic
M6D84_02160	COG2190	(PTS) system
M6D84_02160	COG1263	PTS System
M6D84_02160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M6D84_02190	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M6D84_02210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M6D84_02215	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M6D84_02220	COG1116	anion transmembrane transporter activity
M6D84_02270	COG2270	Major facilitator Superfamily
M6D84_02300	COG2310	stress, protein
M6D84_02305	COG2310	stress, protein
M6D84_02310	COG2310	stress, protein
M6D84_02315	COG0861	Integral membrane protein TerC family
M6D84_02325	COG3853	Toxic anion resistance protein (TelA)
M6D84_02340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M6D84_02350	COG1295	ribonuclease BN
M6D84_02355	COG2217	Heavy metal translocating P-type atpase
M6D84_02360	COG0697	spore germination
M6D84_02370	COG0681	Belongs to the peptidase S26 family
M6D84_02380	COG0586	Pfam SNARE associated Golgi protein
M6D84_02395	COG3871	stress protein (general stress protein 26)
M6D84_02400	COG0387	Pfam Sodium calcium exchanger
M6D84_02410	COG0535	radical SAM domain protein
M6D84_02430	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M6D84_02435	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M6D84_02450	COG3829	transcription factor binding
M6D84_02460	COG0833	amino acid
M6D84_02465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M6D84_02495	COG1263	PTS System
M6D84_02495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M6D84_02500	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M6D84_02515	COG0463	Glycosyl transferase, family 2
M6D84_02525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M6D84_02525	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M6D84_02545	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M6D84_02565	COG1228	amidohydrolase
M6D84_02570	COG1090	epimerase
M6D84_02600	COG1988	membrane-bound metal-dependent
M6D84_02605	COG1194	a g-specific adenine glycosylase
M6D84_02630	COG1132	(ABC) transporter
M6D84_02635	COG4129	membrane
M6D84_02640	COG0070	glutamate synthase
M6D84_02640	COG0069	glutamate synthase activity
M6D84_02640	COG0067	glutamate synthase
M6D84_02650	COG4555	ABC transporter
M6D84_02670	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M6D84_02675	COG0735	belongs to the Fur family
M6D84_02795	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M6D84_02820	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M6D84_02830	COG2766	serine protein kinase
M6D84_02850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M6D84_02860	COG1585	Membrane protein implicated in regulation of membrane protease activity
M6D84_02865	COG2268	Band 7 protein
M6D84_02875	COG3290	protein histidine kinase activity
M6D84_02880	COG4565	transcriptional regulatory protein
M6D84_02885	COG2851	Citrate transporter
M6D84_02910	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
M6D84_02915	COG3842	ATPase activity
M6D84_02920	COG1175	transmembrane transport
M6D84_02925	COG0395	ABC-type sugar transport system, permease component
M6D84_02935	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M6D84_02940	COG0745	RESPONSE REGULATOR receiver
M6D84_02945	COG5002	protein histidine kinase activity
M6D84_02945	COG3850	Histidine kinase
M6D84_02955	COG4990	cell redox homeostasis
M6D84_02965	COG3290	protein histidine kinase activity
M6D84_02970	COG4565	transcriptional regulatory protein
M6D84_02975	COG3493	citrate carrier protein
M6D84_02980	COG0281	malic enzyme
M6D84_02990	COG0697	spore germination
M6D84_02995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M6D84_03005	COG5002	protein histidine kinase activity
M6D84_03015	COG0456	acetyltransferase
M6D84_03015	COG0454	-acetyltransferase
M6D84_03020	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M6D84_03025	COG3383	formate dehydrogenase (NAD+) activity
M6D84_03030	COG2427	Protein of unknown function (DUF1641)
M6D84_03045	COG0531	amino acid
M6D84_03055	COG0640	Transcriptional regulator
M6D84_03060	COG2217	Heavy metal translocating P-type atpase
M6D84_03065	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M6D84_03080	COG3227	Zinc metalloprotease (Elastase)
M6D84_03100	COG2720	vancomycin resistance protein
M6D84_03105	COG1316	TRANSCRIPTIONal
M6D84_03110	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M6D84_03115	COG0346	lactoylglutathione lyase activity
M6D84_03120	COG1253	flavin adenine dinucleotide binding
M6D84_03125	COG1027	Aspartate ammonia-lyase
M6D84_03130	COG1620	l-lactate permease
M6D84_03145	COG3104	oligopeptide transport
M6D84_03150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M6D84_03155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M6D84_03160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M6D84_03170	COG2226	methyltransferase
M6D84_03180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M6D84_03190	COG4548	von Willebrand factor, type A
M6D84_03195	COG0714	Associated with various cellular activities
M6D84_03215	COG0531	amino acid
M6D84_03220	COG2188	Transcriptional regulator
M6D84_03225	COG1263	PTS System
M6D84_03225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M6D84_03230	COG0366	Alpha amylase catalytic
M6D84_03245	COG0697	spore germination
M6D84_03250	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M6D84_03255	COG1115	amino acid carrier protein
M6D84_03260	COG1126	abc transporter atp-binding protein
M6D84_03265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M6D84_03270	COG0765	amino acid transport
M6D84_03275	COG0765	amino acid transport
M6D84_03280	COG0833	amino acid
M6D84_03295	COG2378	regulation of single-species biofilm formation
M6D84_03300	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M6D84_03305	COG5002	protein histidine kinase activity
M6D84_03320	COG0659	secondary active sulfate transmembrane transporter activity
M6D84_03335	COG2271	Major facilitator Superfamily
M6D84_03340	COG1846	Transcriptional regulator
M6D84_03345	COG0477	Major facilitator Superfamily
M6D84_03350	COG1609	Transcriptional regulator
M6D84_03355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M6D84_03370	COG1172	Belongs to the binding-protein-dependent transport system permease family
M6D84_03375	COG1879	ABC-type sugar transport system periplasmic component
M6D84_03400	COG1063	alcohol dehydrogenase
M6D84_03450	COG0840	transmembrane signaling receptor activity
M6D84_03455	COG1388	LysM domain
M6D84_03455	COG3584	3D domain protein
M6D84_03460	COG1476	TRANSCRIPTIONal
M6D84_03480	COG3104	oligopeptide transport
M6D84_03485	COG1114	Component of the transport system for branched-chain amino acids
M6D84_03500	COG1113	amino acid transport
M6D84_03505	COG2252	PERMEase
M6D84_03530	COG2153	protein acetylation
M6D84_03540	COG0569	domain protein
M6D84_03540	COG0475	glutathione-regulated potassium exporter activity
M6D84_03550	COG1845	cytochrome c oxidase, subunit III
M6D84_03555	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M6D84_03565	COG0833	amino acid
M6D84_03570	COG4990	cell redox homeostasis
M6D84_03585	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M6D84_03590	COG0697	spore germination
M6D84_03595	COG0531	amino acid
M6D84_03610	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
M6D84_03615	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
M6D84_03620	COG1918	ferrous iron import across plasma membrane
M6D84_03620	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
M6D84_03625	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M6D84_03630	COG0573	inorganic phosphate transmembrane transporter activity
M6D84_03635	COG0581	inorganic phosphate transmembrane transporter activity
M6D84_03640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M6D84_03760	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
M6D84_03780	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M6D84_03785	COG1116	anion transmembrane transporter activity
M6D84_03790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M6D84_03795	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M6D84_03800	COG0352	thiamine-phosphate diphosphorylase activity
M6D84_03805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M6D84_03810	COG2104	thiamine diphosphate biosynthetic process
M6D84_03820	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M6D84_03825	COG0351	phosphomethylpyrimidine kinase
M6D84_03865	COG2205	protein histidine kinase activity
M6D84_03870	COG2814	Major facilitator Superfamily
M6D84_03875	COG1846	Transcriptional regulator
M6D84_03885	COG2252	PERMEase
M6D84_03890	COG1028	Short-chain dehydrogenase reductase Sdr
M6D84_03905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M6D84_03910	COG1621	beta-fructofuranosidase activity
M6D84_03915	COG1263	PTS System
M6D84_03915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M6D84_03920	COG1609	Transcriptional regulator
M6D84_03970	COG0778	Nitroreductase
M6D84_03975	COG2719	SpoVR family
M6D84_03985	COG3591	Belongs to the peptidase S1B family
M6D84_03995	COG1414	Transcriptional regulator
M6D84_04010	COG0446	pyridine nucleotide-disulphide oxidoreductase
M6D84_04015	COG1937	Protein conserved in bacteria
M6D84_04020	COG0425	Belongs to the sulfur carrier protein TusA family
M6D84_04020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M6D84_04025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M6D84_04025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M6D84_04030	COG0425	Belongs to the sulfur carrier protein TusA family
M6D84_04035	COG0425	Belongs to the sulfur carrier protein TusA family
M6D84_04035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M6D84_04040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M6D84_04045	COG2210	Belongs to the sulfur carrier protein TusA family
M6D84_04050	COG0730	response to heat
M6D84_04060	COG1316	TRANSCRIPTIONal
M6D84_04065	COG0604	alcohol dehydrogenase
M6D84_04070	COG1283	sodium-dependent phosphate transmembrane transporter activity
M6D84_04085	COG3711	transcriptional antiterminator
M6D84_04085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M6D84_04090	COG1447	Phosphotransferase system cellobiose-specific component IIA
M6D84_04095	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M6D84_04120	COG3584	3D domain protein
M6D84_04120	COG1388	LysM domain
M6D84_04125	COG0577	efflux transmembrane transporter activity
M6D84_04130	COG1136	(ABC) transporter
M6D84_04140	COG5522	Integral membrane protein (intg_mem_TP0381)
M6D84_04155	COG1114	Component of the transport system for branched-chain amino acids
M6D84_04160	COG3546	catalase activity
M6D84_04195	COG0586	Pfam SNARE associated Golgi protein
M6D84_04230	COG0531	amino acid
M6D84_04235	COG0475	glutathione-regulated potassium exporter activity
M6D84_04245	COG1737	Transcriptional regulator
M6D84_04255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M6D84_04255	COG1263	PTS System
M6D84_04265	COG2259	Doxx family
M6D84_04285	COG1522	sequence-specific DNA binding
M6D84_04290	COG0165	Argininosuccinate lyase
M6D84_04290	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M6D84_04295	COG0300	oxidoreductase activity
M6D84_04315	COG1309	transcriptional regulator
M6D84_04320	COG2814	Major facilitator Superfamily
M6D84_04325	COG1733	regulation of RNA biosynthetic process
M6D84_04340	COG4533	DNA binding
M6D84_04345	COG2211	Major facilitator Superfamily
M6D84_04360	COG0693	protein deglycase activity
M6D84_04365	COG0753	catalase activity
M6D84_04365	COG0693	protein deglycase activity
M6D84_04375	COG0531	amino acid
M6D84_04380	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M6D84_04390	COG1012	belongs to the aldehyde dehydrogenase family
M6D84_04395	COG1132	(ABC) transporter
M6D84_04400	COG1132	(ABC) transporter
M6D84_04405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M6D84_04410	COG0765	amino acid transport
M6D84_04415	COG1126	abc transporter atp-binding protein
M6D84_04430	COG0189	ligase activity
M6D84_04465	COG0028	Belongs to the TPP enzyme family
M6D84_04470	COG3527	Alpha-acetolactate decarboxylase
M6D84_04480	COG0561	phosphatase activity
M6D84_04490	COG3409	Peptidoglycan-binding domain 1 protein
M6D84_04490	COG5632	N-Acetylmuramoyl-L-alanine amidase
M6D84_04495	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M6D84_04515	COG0659	secondary active sulfate transmembrane transporter activity
M6D84_04520	COG2244	polysaccharide biosynthetic process
M6D84_04540	COG1024	Enoyl-CoA hydratase
M6D84_04560	COG1363	Peptidase, m42
M6D84_04595	COG0601	transmembrane transport
M6D84_04600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M6D84_04605	COG0444	Belongs to the ABC transporter superfamily
M6D84_04610	COG4608	Belongs to the ABC transporter superfamily
M6D84_04620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M6D84_04635	COG1136	(ABC) transporter
M6D84_04635	COG0577	efflux transmembrane transporter activity
M6D84_04690	COG0477	Major facilitator Superfamily
M6D84_04695	COG3290	protein histidine kinase activity
M6D84_04700	COG4565	transcriptional regulatory protein
M6D84_04705	COG3181	Tripartite tricarboxylate transporter family receptor
M6D84_04725	COG3973	AAA domain
M6D84_04765	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M6D84_04790	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M6D84_04815	COG0305	Participates in initiation and elongation during chromosome replication
M6D84_04845	COG0477	Major facilitator Superfamily
M6D84_04865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M6D84_04875	COG1073	alpha beta
M6D84_04915	COG1183	phosphatidylcholine synthase activity
M6D84_04930	COG2376	Dihydroxyacetone kinase
M6D84_04940	COG2376	Dihydroxyacetone kinase
M6D84_04975	COG3584	3D domain protein
M6D84_04975	COG1388	LysM domain
M6D84_04980	COG1388	LysM domain
M6D84_04980	COG0791	NLP P60 protein
M6D84_04985	COG2373	Large extracellular alpha-helical protein
M6D84_05055	COG1191	sigma factor activity
M6D84_05065	COG2208	phosphoserine phosphatase activity
M6D84_05070	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M6D84_05075	COG0784	Response regulator, receiver
M6D84_05075	COG2205	protein histidine kinase activity
M6D84_05075	COG5002	protein histidine kinase activity
M6D84_05120	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
M6D84_05140	COG0420	3'-5' exonuclease activity
M6D84_05145	COG4717	serine-type aminopeptidase activity
M6D84_05155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M6D84_05170	COG0346	lactoylglutathione lyase activity
M6D84_05175	COG0346	lactoylglutathione lyase activity
M6D84_05180	COG0457	Tetratricopeptide repeat
M6D84_05190	COG2267	carboxylic ester hydrolase activity
M6D84_05215	COG2140	Oxalate decarboxylase
M6D84_05220	COG3620	sequence-specific DNA binding
M6D84_05225	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
M6D84_05230	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M6D84_05240	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M6D84_05245	COG1695	Transcriptional regulator
M6D84_05275	COG3973	AAA domain
M6D84_05305	COG4980	gas vesicle protein
M6D84_05310	COG0537	adenosine 5'-monophosphoramidase activity
M6D84_05315	COG1131	(ABC) transporter
M6D84_05320	COG4473	ABC transporter
M6D84_05345	COG3402	PFAM membrane-flanked domain
M6D84_05350	COG3428	Bacterial PH domain
M6D84_05385	COG0697	spore germination
M6D84_05390	COG3402	PFAM membrane-flanked domain
M6D84_05400	COG2329	Antibiotic biosynthesis monooxygenase
M6D84_05405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M6D84_05420	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
M6D84_05455	COG1309	transcriptional regulator
M6D84_05460	COG1511	domain protein
M6D84_05490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M6D84_05495	COG1609	Transcriptional regulator
M6D84_05505	COG1234	tRNA 3'-trailer cleavage
M6D84_05510	COG0095	Lipoate-protein ligase
M6D84_05520	COG0318	PFAM AMP-dependent synthetase and ligase
M6D84_05530	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M6D84_05540	COG4208	sulfate ABC transporter
M6D84_05635	COG1408	metallophosphoesterase
M6D84_05640	COG1078	dGTPase activity
M6D84_05650	COG1595	DNA-templated transcription, initiation
M6D84_05655	COG3708	Transcriptional regulator
M6D84_05655	COG2207	Transcriptional regulator
M6D84_05665	COG2205	protein histidine kinase activity
M6D84_05670	COG0745	RESPONSE REGULATOR receiver
M6D84_05690	COG0501	Belongs to the peptidase M48B family
M6D84_05695	COG0840	transmembrane signaling receptor activity
M6D84_05700	COG3693	PFAM glycoside hydrolase, family 10
M6D84_05710	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M6D84_05715	COG2224	Isocitrate lyase
M6D84_05730	COG1278	Cold shock
M6D84_05750	COG0398	Pfam SNARE associated Golgi protein
M6D84_05810	COG0179	Fumarylacetoacetate (FAA) hydrolase
M6D84_05835	COG0367	asparagine synthase
M6D84_05845	COG0753	catalase activity
M6D84_05850	COG0004	ammonium transporteR
M6D84_05870	COG2996	Protein conserved in bacteria
M6D84_05885	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M6D84_05900	COG0561	phosphatase activity
M6D84_05920	COG2267	carboxylic ester hydrolase activity
M6D84_05940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M6D84_05945	COG5504	Zn-dependent protease
M6D84_05955	COG0180	Tryptophanyl-tRNA synthetase
M6D84_05965	COG4166	transmembrane transport
M6D84_05970	COG0601	transmembrane transport
M6D84_05975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M6D84_05980	COG0444	Belongs to the ABC transporter superfamily
M6D84_05985	COG4608	Belongs to the ABC transporter superfamily
M6D84_05990	COG0534	Mate efflux family protein
M6D84_05995	COG4166	transmembrane transport
M6D84_06010	COG0861	Integral membrane protein TerC family
M6D84_06030	COG1164	Oligoendopeptidase f
M6D84_06045	COG2346	COG2346, Truncated hemoglobins
M6D84_06050	COG4116	CYTH
M6D84_06060	COG2357	RelA SpoT domain protein
M6D84_06070	COG0564	pseudouridine synthase activity
M6D84_06085	COG0772	Belongs to the SEDS family
M6D84_06090	COG1216	Glycosyl transferase, family 2
M6D84_06110	COG0457	Tetratricopeptide repeat
M6D84_06110	COG0463	Glycosyl transferase, family 2
M6D84_06130	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M6D84_06145	COG1091	dTDP-4-dehydrorhamnose reductase activity
M6D84_06190	COG2153	protein acetylation
M6D84_06200	COG2382	esterase
M6D84_06225	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M6D84_06235	COG0512	Glutamine amidotransferase of anthranilate synthase
M6D84_06235	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M6D84_06270	COG1620	l-lactate permease
M6D84_06275	COG5634	Uncharacterized conserved protein (DUF2278)
M6D84_06325	COG0508	dehydrogenase complex catalyzes the overall conversion of
M6D84_06335	COG1476	TRANSCRIPTIONal
M6D84_06395	COG1686	Belongs to the peptidase S11 family
M6D84_06400	COG0681	Belongs to the peptidase S26 family
M6D84_06435	COG1012	belongs to the aldehyde dehydrogenase family
M6D84_06445	COG1176	ABC-type spermidine putrescine transport system, permease component I
M6D84_06450	COG1177	transmembrane transport
M6D84_06465	COG2409	Drug exporters of the RND superfamily
M6D84_06475	COG0564	pseudouridine synthase activity
M6D84_06485	COG2340	Cysteine-rich secretory protein family
M6D84_06490	COG0247	lactate metabolic process
M6D84_06495	COG0277	FAD linked oxidase domain protein
M6D84_06500	COG3835	regulator
M6D84_06510	COG0745	RESPONSE REGULATOR receiver
M6D84_06515	COG5002	protein histidine kinase activity
M6D84_06520	COG2186	Transcriptional regulator
M6D84_06540	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M6D84_06550	COG2116	formate transmembrane transporter activity
M6D84_06555	COG0861	Integral membrane protein TerC family
M6D84_06560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M6D84_06570	COG2030	dehydratase
M6D84_06590	COG1028	Short-chain dehydrogenase reductase Sdr
M6D84_06595	COG3243	poly(R)-hydroxyalkanoic acid synthase
M6D84_06605	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M6D84_06620	COG1840	ABC-type Fe3 transport system, periplasmic component
M6D84_06625	COG3842	ATPase activity
M6D84_06650	COG1349	DNA-binding transcription factor activity
M6D84_06660	COG0235	Class ii aldolase
M6D84_06670	COG2861	carbohydrate metabolic process
M6D84_06680	COG3852	Histidine kinase
M6D84_06685	COG1846	Transcriptional regulator
M6D84_06695	COG2318	DinB family
M6D84_06705	COG5002	protein histidine kinase activity
M6D84_06715	COG0720	synthase
M6D84_06730	COG4873	Protein conserved in bacteria
M6D84_06755	COG1780	Probably involved in ribonucleotide reductase function
M6D84_06760	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M6D84_06765	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M6D84_06770	COG1725	Transcriptional regulator
M6D84_06775	COG1131	(ABC) transporter
M6D84_06785	COG1131	(ABC) transporter
M6D84_06790	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M6D84_06805	COG1522	sequence-specific DNA binding
M6D84_06815	COG1335	isochorismatase
M6D84_06825	COG1619	proteins homologs of microcin C7 resistance protein MccF
M6D84_06830	COG2070	2-Nitropropane dioxygenase
M6D84_06835	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
M6D84_06845	COG1696	Membrane protein involved in D-alanine export
M6D84_06870	COG0716	FMN binding
M6D84_06925	COG1846	Transcriptional regulator
M6D84_06935	COG1301	dicarboxylic acid transport
M6D84_06940	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M6D84_06945	COG4709	membrane
M6D84_06950	COG3874	Sporulation protein YtfJ
M6D84_06970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M6D84_06975	COG0028	Belongs to the TPP enzyme family
M6D84_06980	COG0440	acetolactate synthase activity
M6D84_07055	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M6D84_07070	COG1183	phosphatidylcholine synthase activity
M6D84_07075	COG1368	sulfuric ester hydrolase activity
M6D84_07085	COG0019	diaminopimelate decarboxylase activity
M6D84_07105	COG0529	Catalyzes the synthesis of activated sulfate
M6D84_07110	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M6D84_07130	COG1648	precorrin-2 dehydrogenase activity
M6D84_07135	COG0733	neurotransmitter:sodium symporter activity
M6D84_07160	COG1757	Na H antiporter
M6D84_07175	COG4758	membrane
M6D84_07180	COG4585	Histidine kinase
M6D84_07185	COG2197	response regulator
M6D84_07195	COG1114	Component of the transport system for branched-chain amino acids
M6D84_07245	COG0730	response to heat
M6D84_07250	COG0306	phosphate transporter
M6D84_07255	COG1392	Phosphate transport regulator
M6D84_07260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M6D84_07275	COG3852	Histidine kinase
M6D84_07280	COG1801	Protein of unknown function DUF72
M6D84_07290	COG0582	viral genome integration into host DNA
M6D84_07295	COG5002	protein histidine kinase activity
M6D84_07310	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M6D84_07310	COG0392	lysyltransferase activity
M6D84_07325	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M6D84_07330	COG1686	Belongs to the peptidase S11 family
M6D84_07335	COG2715	membrane protein required for spore maturation
M6D84_07340	COG0700	Nucleoside recognition
M6D84_07345	COG1187	pseudouridine synthase activity
M6D84_07355	COG1333	cytochrome c biogenesis protein
M6D84_07360	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M6D84_07365	COG0745	RESPONSE REGULATOR receiver
M6D84_07370	COG5002	protein histidine kinase activity
M6D84_07375	COG2096	Adenosyltransferase
M6D84_07390	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
M6D84_07395	COG1141	Ferredoxin
M6D84_07405	COG0514	ATP-dependent DNA helicase (RecQ)
M6D84_07410	COG1266	CAAX protease self-immunity
M6D84_07420	COG1408	metallophosphoesterase
M6D84_07425	COG0789	Transcriptional regulator
M6D84_07435	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M6D84_07455	COG0492	ferredoxin-NADP+ reductase activity
M6D84_07460	COG0252	asparaginase activity
M6D84_07530	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M6D84_07545	COG0142	geranyltranstransferase activity
M6D84_07555	COG0142	geranyltranstransferase activity
M6D84_07580	COG0457	Tetratricopeptide repeat
M6D84_07600	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M6D84_07605	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M6D84_07605	COG2010	Cytochrome c
M6D84_07610	COG4347	Protein of unknown function (DUF1405)
M6D84_07625	COG2738	Putative neutral zinc metallopeptidase
M6D84_07640	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M6D84_07645	COG1694	Mazg nucleotide pyrophosphohydrolase
M6D84_07665	COG0438	transferase activity, transferring glycosyl groups
M6D84_07700	COG1199	ATP-dependent helicase activity
M6D84_07700	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M6D84_07720	COG3935	DnaD domain protein
M6D84_07725	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M6D84_07735	COG4499	WXG100 protein secretion system (Wss), protein YukC
M6D84_07735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M6D84_07790	COG0116	Belongs to the methyltransferase superfamily
M6D84_07810	COG0457	Tetratricopeptide repeat
M6D84_07830	COG1199	ATP-dependent helicase activity
M6D84_07835	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M6D84_07845	COG0024	Methionine aminopeptidase
M6D84_07855	COG2233	PERMEase
M6D84_07860	COG2311	Membrane
M6D84_07865	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M6D84_07875	COG0456	acetyltransferase
M6D84_07925	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M6D84_07940	COG3944	biosynthesis protein
M6D84_07950	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M6D84_07965	COG1215	transferase activity, transferring glycosyl groups
M6D84_07970	COG0438	transferase activity, transferring glycosyl groups
M6D84_07985	COG0454	-acetyltransferase
M6D84_08005	COG0328	RNA-DNA hybrid ribonuclease activity
M6D84_08040	COG3403	YqcI/YcgG family
M6D84_08045	COG1280	lysine exporter protein (LysE YggA)
M6D84_08065	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M6D84_08070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M6D84_08080	COG0475	glutathione-regulated potassium exporter activity
M6D84_08085	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M6D84_08090	COG0789	Transcriptional regulator
M6D84_08090	COG4978	Transcriptional regulator
M6D84_08100	COG2323	membrane
M6D84_08105	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M6D84_08155	COG1923	regulation of RNA biosynthetic process
M6D84_08165	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M6D84_08170	COG1360	Flagellar Motor Protein
M6D84_08175	COG2201	protein-glutamate methylesterase activity
M6D84_08180	COG2198	Histidine kinase
M6D84_08180	COG0643	Histidine kinase
M6D84_08185	COG1776	CheC inhibitor of MCP methylation
M6D84_08185	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M6D84_08200	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M6D84_08220	COG1256	bacterial-type flagellum assembly
M6D84_08225	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M6D84_08245	COG1815	bacterial-type flagellum-dependent cell motility
M6D84_08250	COG1558	bacterial-type flagellum-dependent cell motility
M6D84_08260	COG1766	The M ring may be actively involved in energy transduction
M6D84_08265	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M6D84_08275	COG1157	protein secretion by the type III secretion system
M6D84_08295	COG1749	Flagellar hook protein flgE
M6D84_08310	COG0784	Response regulator, receiver
M6D84_08310	COG0835	chemotaxis
M6D84_08325	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M6D84_08330	COG0741	lytic transglycosylase activity
M6D84_08340	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M6D84_08345	COG1776	CheC inhibitor of MCP methylation
M6D84_08345	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M6D84_08355	COG1338	Plays a role in the flagellum-specific transport system
M6D84_08360	COG1987	bacterial-type flagellum assembly
M6D84_08370	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M6D84_08375	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M6D84_08380	COG1419	protein localization to endoplasmic reticulum
M6D84_08385	COG4786	Flagellar basal body rod
M6D84_08390	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M6D84_08425	COG2329	Antibiotic biosynthesis monooxygenase
M6D84_08450	COG0583	DNA-binding transcription factor activity
M6D84_08455	COG3842	ATPase activity
M6D84_08465	COG1177	transmembrane transport
M6D84_08470	COG1234	tRNA 3'-trailer cleavage
M6D84_08500	COG0406	alpha-ribazole phosphatase activity
M6D84_08530	COG0367	asparagine synthase
M6D84_08565	COG0697	spore germination
M6D84_08575	COG0523	cobalamin synthesis protein
M6D84_08580	COG0701	Predicted permease
M6D84_08595	COG1757	Na H antiporter
M6D84_08600	COG0789	Transcriptional regulator
M6D84_08630	COG0534	Mate efflux family protein
M6D84_08635	COG3340	Belongs to the peptidase S51 family
M6D84_08655	COG0785	Cytochrome C biogenesis protein
M6D84_08660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M6D84_08680	COG2733	membrane
M6D84_08715	COG1131	(ABC) transporter
M6D84_08735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M6D84_08740	COG0528	UMP kinase activity
M6D84_08750	COG1027	Aspartate ammonia-lyase
M6D84_08755	COG0281	malic enzyme
M6D84_08760	COG4191	Histidine kinase
M6D84_08765	COG0784	Response regulator, receiver
M6D84_08770	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M6D84_08785	COG3620	sequence-specific DNA binding
M6D84_08820	COG2814	Major facilitator Superfamily
M6D84_08835	COG1695	Transcriptional regulator
M6D84_08850	COG0477	Major facilitator Superfamily
M6D84_08865	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M6D84_08870	COG2223	nitrite transmembrane transporter activity
M6D84_08875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M6D84_08895	COG0733	neurotransmitter:sodium symporter activity
M6D84_08905	COG5566	PFAM Mor transcription activator
M6D84_08910	COG2323	membrane
M6D84_08930	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M6D84_08940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M6D84_08945	COG0028	Belongs to the TPP enzyme family
M6D84_08965	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M6D84_08985	COG2814	Major facilitator Superfamily
M6D84_08990	COG3384	dioxygenase
M6D84_09000	COG3279	Response regulator of the LytR AlgR family
M6D84_09005	COG0427	acetyl-CoA hydrolase
M6D84_09025	COG4166	transmembrane transport
M6D84_09030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M6D84_09050	COG1914	H( )-stimulated, divalent metal cation uptake system
M6D84_09065	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M6D84_09070	COG0531	amino acid
M6D84_09090	COG2309	aminopeptidase activity
M6D84_09105	COG0456	acetyltransferase
M6D84_09115	COG1266	CAAX protease self-immunity
M6D84_09120	COG1309	transcriptional regulator
M6D84_09125	COG2390	Transcriptional regulator
M6D84_09135	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M6D84_09140	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M6D84_09155	COG4846	Membrane protein involved in cytochrome C biogenesis
M6D84_09165	COG0006	proline dipeptidase activity
M6D84_09175	COG2132	Multicopper oxidase
M6D84_09185	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M6D84_09205	COG1114	Component of the transport system for branched-chain amino acids
M6D84_09215	COG2372	response to copper ion
M6D84_09215	COG1276	copper resistance
M6D84_09220	COG4549	nuclear export factor GLE1
M6D84_09225	COG0697	spore germination
M6D84_09230	COG0583	DNA-binding transcription factor activity
M6D84_09235	COG1959	2 iron, 2 sulfur cluster binding
M6D84_09240	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M6D84_09245	COG0778	Nitroreductase
M6D84_09255	COG0628	permease
M6D84_09265	COG1231	oxidoreductase activity
M6D84_09270	COG0523	cobalamin synthesis protein
M6D84_09285	COG0411	ABC transporter
M6D84_09305	COG0583	DNA-binding transcription factor activity
M6D84_09340	COG1271	oxidase subunit
M6D84_09345	COG1294	oxidase, subunit
M6D84_09350	COG4988	ABC transporter
M6D84_09355	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M6D84_09365	COG1216	Glycosyl transferase, family 2
M6D84_09405	COG1686	Belongs to the peptidase S11 family
M6D84_09420	COG0791	NLP P60 protein
M6D84_09420	COG1388	LysM domain
M6D84_09430	COG1132	(ABC) transporter
M6D84_09435	COG0745	RESPONSE REGULATOR receiver
M6D84_09440	COG5002	protein histidine kinase activity
M6D84_09445	COG0300	oxidoreductase activity
M6D84_09475	COG0460	homoserine dehydrogenase
M6D84_09500	COG1316	TRANSCRIPTIONal
M6D84_09510	COG0745	RESPONSE REGULATOR receiver
M6D84_09515	COG5002	protein histidine kinase activity
M6D84_09530	COG1285	pathogenesis
M6D84_09535	COG1247	-acetyltransferase
M6D84_09555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M6D84_09565	COG1082	Xylose isomerase domain protein TIM barrel
M6D84_09575	COG2814	Major facilitator Superfamily
M6D84_09580	COG1279	arginine transmembrane transporter activity
M6D84_09585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M6D84_09595	COG1752	Esterase of the alpha-beta hydrolase superfamily
M6D84_09630	COG0577	efflux transmembrane transporter activity
M6D84_09635	COG2002	toxin-antitoxin pair type II binding
M6D84_09640	COG1404	Belongs to the peptidase S8 family
M6D84_09645	COG0640	Transcriptional regulator
M6D84_09650	COG0667	Aldo Keto reductase
M6D84_09655	COG2814	Major facilitator Superfamily
M6D84_09660	COG3152	Membrane
M6D84_09685	COG0840	transmembrane signaling receptor activity
M6D84_09700	COG3949	Membrane
M6D84_09705	COG0783	Belongs to the Dps family
M6D84_09720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M6D84_09730	COG1231	oxidoreductase activity
M6D84_09735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M6D84_09740	COG4989	oxidoreductase activity
M6D84_09745	COG0523	cobalamin synthesis protein
M6D84_09750	COG0456	acetyltransferase
M6D84_09755	COG0803	Belongs to the bacterial solute-binding protein 9 family
M6D84_09765	COG0702	epimerase
M6D84_09775	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M6D84_09785	COG4166	transmembrane transport
M6D84_09810	COG5337	Spore coat protein CotH
M6D84_09815	COG1051	belongs to the nudix hydrolase family
M6D84_09820	COG0586	Pfam SNARE associated Golgi protein
M6D84_09825	COG2244	polysaccharide biosynthetic process
M6D84_09835	COG0701	Predicted permease
M6D84_09840	COG3689	TIGRFAM TIGR03943 family protein
M6D84_09845	COG1607	acyl-coa hydrolase
M6D84_09855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M6D84_09870	COG0702	epimerase
M6D84_09875	COG2839	Protein conserved in bacteria
M6D84_09880	COG1253	flavin adenine dinucleotide binding
M6D84_09895	COG1114	Component of the transport system for branched-chain amino acids
M6D84_09900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M6D84_09920	COG0860	N-Acetylmuramoyl-L-alanine amidase
M6D84_09930	COG1876	peptidase activity
M6D84_09940	COG0154	amidase activity
M6D84_09945	COG2211	Major facilitator Superfamily
M6D84_09960	COG0860	N-Acetylmuramoyl-L-alanine amidase
M6D84_09970	COG0561	phosphatase activity
M6D84_09985	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M6D84_10005	COG1819	glycosyl
M6D84_10010	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M6D84_10015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M6D84_10045	COG0456	acetyltransferase
M6D84_10080	COG4499	WXG100 protein secretion system (Wss), protein YukC
M6D84_10170	COG3874	Sporulation protein YtfJ
M6D84_10195	COG2226	methyltransferase
M6D84_10225	COG0582	viral genome integration into host DNA
M6D84_10250	COG1396	sequence-specific DNA binding
M6D84_10285	COG2002	toxin-antitoxin pair type II binding
M6D84_10355	COG0582	viral genome integration into host DNA
M6D84_10475	COG5632	N-Acetylmuramoyl-L-alanine amidase
M6D84_10520	COG0604	alcohol dehydrogenase
M6D84_10525	COG1595	DNA-templated transcription, initiation
M6D84_10550	COG0386	Belongs to the glutathione peroxidase family
M6D84_10555	COG1305	Transglutaminase-like
M6D84_10560	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
M6D84_10565	COG0714	Associated with various cellular activities
M6D84_10570	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
M6D84_10575	COG1140	nitrate reductase beta subunit
M6D84_10580	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
M6D84_10585	COG2181	nitrate reductase activity
M6D84_10590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M6D84_10595	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M6D84_10600	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M6D84_10605	COG0303	'Molybdopterin
M6D84_10610	COG0314	molybdopterin synthase activity
M6D84_10620	COG2223	nitrite transmembrane transporter activity
M6D84_10640	COG1648	precorrin-2 dehydrogenase activity
M6D84_10650	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M6D84_10650	COG1587	Uroporphyrinogen-III synthase
M6D84_10655	COG2146	nitrite reductase [NAD(P)H] activity
M6D84_10660	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M6D84_10665	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
M6D84_10700	COG2359	stage V sporulation protein S
M6D84_10725	COG0457	Tetratricopeptide repeat
M6D84_10740	COG1418	mRNA catabolic process
M6D84_10745	COG0488	(ABC) transporter
M6D84_10760	COG0629	single-stranded DNA binding
M6D84_10765	COG1413	lyase activity
M6D84_10780	COG2521	methyltransferase
M6D84_10780	COG2136	Putative SAM-dependent methyltransferase
M6D84_10785	COG0018	arginyl-trna synthetase
M6D84_10835	COG0017	Asparaginyl-tRNA synthetase
M6D84_10840	COG0733	neurotransmitter:sodium symporter activity
M6D84_10865	COG2610	gluconate transmembrane transporter activity
M6D84_10875	COG1794	racemase activity, acting on amino acids and derivatives
M6D84_10885	COG0456	acetyltransferase
M6D84_10895	COG3655	Transcriptional regulator
M6D84_10900	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M6D84_10910	COG1131	(ABC) transporter
M6D84_10915	COG4473	ABC transporter
M6D84_10925	COG0546	phosphoglycolate phosphatase activity
M6D84_10940	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M6D84_10955	COG0768	penicillin binding
M6D84_10965	COG0204	Acyl-transferase
M6D84_10970	COG1272	protein, Hemolysin III
M6D84_10980	COG0805	protein transport
M6D84_10990	COG1307	EDD domain protein, DegV family
M6D84_11000	COG1999	signal sequence binding
M6D84_11005	COG0071	Belongs to the small heat shock protein (HSP20) family
M6D84_11010	COG0367	asparagine synthase
M6D84_11025	COG0860	N-Acetylmuramoyl-L-alanine amidase
M6D84_11030	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M6D84_11035	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M6D84_11050	COG1335	isochorismatase
M6D84_11065	COG0668	transmembrane transport
M6D84_11070	COG4585	Histidine kinase
M6D84_11070	COG2203	Gaf domain
M6D84_11075	COG2197	response regulator
M6D84_11080	COG1737	Transcriptional regulator
M6D84_11085	COG0384	phenazine biosynthesis protein PhzF
M6D84_11090	COG1064	alcohol dehydrogenase
M6D84_11115	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
M6D84_11150	COG0517	IMP dehydrogenase activity
M6D84_11150	COG1125	glycine betaine transport
M6D84_11155	COG1174	glycine betaine transport
M6D84_11190	COG1253	flavin adenine dinucleotide binding
M6D84_11195	COG1012	belongs to the aldehyde dehydrogenase family
M6D84_11200	COG5506	Protein of unknown function (DUF1694)
M6D84_11220	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M6D84_11225	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M6D84_11230	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M6D84_11235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M6D84_11240	COG0456	acetyltransferase
M6D84_11245	COG3829	transcription factor binding
M6D84_11250	COG1509	lysine 2,3-aminomutase activity
M6D84_11285	COG3064	Membrane
M6D84_11285	COG0515	serine threonine protein kinase
M6D84_11285	COG4991	sh3 domain protein
M6D84_11295	COG0671	phosphoesterase, PA-phosphatase related
M6D84_11300	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M6D84_11305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M6D84_11395	COG0300	oxidoreductase activity
M6D84_11415	COG4499	WXG100 protein secretion system (Wss), protein YukC
M6D84_11415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M6D84_11425	COG2814	Major facilitator Superfamily
M6D84_11430	COG4841	protein insertion into membrane
M6D84_11435	COG0372	Belongs to the citrate synthase family
M6D84_11440	COG2079	MmgE PrpD family protein
M6D84_11445	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
M6D84_11450	COG1960	acyl-CoA dehydrogenase activity
M6D84_11455	COG2084	Dehydrogenase
M6D84_11465	COG1280	lysine exporter protein (LysE YggA)
M6D84_11470	COG1024	Enoyl-CoA hydratase
M6D84_11485	COG0420	3'-5' exonuclease activity
M6D84_11490	COG0419	ATPase involved in DNA repair
M6D84_11515	COG2223	nitrite transmembrane transporter activity
M6D84_11520	COG1028	Short-chain dehydrogenase reductase Sdr
M6D84_11525	COG1169	isochorismate synthase
M6D84_11530	COG1021	2,3-dihydroxybenzoate-AMP ligase
M6D84_11535	COG3433	isochorismatase activity
M6D84_11535	COG1535	isochorismatase
M6D84_11540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M6D84_11545	COG3251	PFAM MbtH domain protein
M6D84_11550	COG2814	Major facilitator Superfamily
M6D84_11565	COG0776	regulation of translation
M6D84_11575	COG2318	DinB family
M6D84_11585	COG1115	amino acid carrier protein
M6D84_11605	COG1187	pseudouridine synthase activity
M6D84_11610	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M6D84_11615	COG1136	(ABC) transporter
M6D84_11640	COG0028	Belongs to the TPP enzyme family
M6D84_11680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M6D84_11705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M6D84_11735	COG1247	-acetyltransferase
M6D84_11760	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
M6D84_11770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M6D84_11800	COG0583	DNA-binding transcription factor activity
M6D84_11805	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M6D84_11825	COG0583	DNA-binding transcription factor activity
M6D84_11830	COG2258	MOSC domain
M6D84_11845	COG1132	(ABC) transporter
M6D84_11850	COG1132	(ABC) transporter
M6D84_11880	COG1396	sequence-specific DNA binding
M6D84_11910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M6D84_11915	COG1595	DNA-templated transcription, initiation
M6D84_11940	COG1649	PFAM Uncharacterised BCR, COG1649
M6D84_11965	COG2971	BadF BadG BcrA BcrD
M6D84_11985	COG1846	Transcriptional regulator
M6D84_12000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M6D84_12020	COG1309	transcriptional regulator
M6D84_12035	COG0582	viral genome integration into host DNA
M6D84_12060	COG3011	Protein conserved in bacteria
M6D84_12095	COG0582	viral genome integration into host DNA
M6D84_12130	COG0500	methyltransferase
M6D84_12130	COG3615	Tellurite resistance protein tehB
M6D84_12140	COG2226	methyltransferase
M6D84_12145	COG3961	Belongs to the TPP enzyme family
M6D84_12150	COG1846	Transcriptional regulator
M6D84_12180	COG2195	Cleaves the N-terminal amino acid of tripeptides
M6D84_12210	COG2002	toxin-antitoxin pair type II binding
M6D84_12225	COG0730	response to heat
M6D84_12230	COG0110	maltose O-acetyltransferase activity
M6D84_12235	COG1686	Belongs to the peptidase S11 family
M6D84_12250	COG2814	Major facilitator Superfamily
M6D84_12280	COG1028	Short-chain dehydrogenase reductase Sdr
M6D84_12310	COG0741	lytic transglycosylase activity
M6D84_12315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M6D84_12370	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M6D84_12375	COG0768	penicillin binding
M6D84_12380	COG1595	DNA-templated transcription, initiation
M6D84_12390	COG0768	penicillin binding
M6D84_12395	COG0768	penicillin binding
M6D84_12405	COG1408	metallophosphoesterase
M6D84_12415	COG1131	(ABC) transporter
M6D84_12425	COG1309	transcriptional regulator
M6D84_12440	COG1960	acyl-CoA dehydrogenase activity
M6D84_12445	COG0439	Biotin carboxylase
M6D84_12450	COG0511	ligase activity, forming carbon-carbon bonds
M6D84_12455	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M6D84_12460	COG1024	Enoyl-CoA hydratase
M6D84_12465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M6D84_12470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M6D84_12490	COG0572	uridine kinase
M6D84_12510	COG1686	Belongs to the peptidase S11 family
M6D84_12535	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M6D84_12550	COG3227	Zinc metalloprotease (Elastase)
M6D84_12555	COG2207	Transcriptional regulator
M6D84_12585	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M6D84_12595	COG2814	Major facilitator Superfamily
M6D84_12600	COG1028	Short-chain dehydrogenase reductase Sdr
M6D84_12605	COG1733	regulation of RNA biosynthetic process
M6D84_12650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M6D84_12660	COG2368	4-hydroxyphenylacetate
M6D84_12675	COG1063	alcohol dehydrogenase
M6D84_12685	COG2323	membrane
M6D84_12700	COG3386	PFAM SMP-30 Gluconolaconase
M6D84_12715	COG3773	Cell wall hydrolase
M6D84_12725	COG0745	RESPONSE REGULATOR receiver
M6D84_12730	COG2205	protein histidine kinase activity
M6D84_12740	COG0488	(ABC) transporter
M6D84_12755	COG0825	malonyl-CoA metabolic process
M6D84_12765	COG1136	(ABC) transporter
M6D84_12770	COG0577	efflux transmembrane transporter activity
M6D84_12790	COG0460	homoserine dehydrogenase
M6D84_12795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M6D84_12805	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M6D84_12865	COG2124	cytochrome p450
M6D84_12900	COG0561	phosphatase activity
M6D84_12905	COG5002	protein histidine kinase activity
M6D84_12910	COG0768	penicillin binding
M6D84_12920	COG1819	glycosyl
M6D84_12925	COG1794	racemase activity, acting on amino acids and derivatives
M6D84_12950	COG2205	protein histidine kinase activity
M6D84_12955	COG0582	viral genome integration into host DNA
M6D84_13005	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M6D84_13010	COG0604	alcohol dehydrogenase
M6D84_13015	COG0671	phosphoesterase, PA-phosphatase related
M6D84_13020	COG0768	penicillin binding
M6D84_13075	COG2814	Major facilitator Superfamily
M6D84_13080	COG4978	Transcriptional regulator
M6D84_13080	COG0789	Transcriptional regulator
M6D84_13100	COG0584	glycerophosphoryl diester phosphodiesterase
M6D84_13120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M6D84_13125	COG0697	spore germination
M6D84_13160	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M6D84_13170	COG2223	nitrite transmembrane transporter activity
M6D84_13185	COG0592	DNA-directed DNA polymerase activity
M6D84_13205	COG3878	Protein conserved in bacteria
M6D84_13215	COG3507	Belongs to the glycosyl hydrolase 43 family
M6D84_13215	COG2382	esterase
M6D84_13215	COG3693	PFAM glycoside hydrolase, family 10
M6D84_13230	COG4667	esterase of the alpha-beta hydrolase superfamily
M6D84_13270	COG0322	excinuclease ABC activity
M6D84_13310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M6D84_13340	COG1011	Hydrolase
M6D84_13345	COG0745	RESPONSE REGULATOR receiver
M6D84_13350	COG5002	protein histidine kinase activity
M6D84_13365	COG1136	(ABC) transporter
M6D84_13370	COG0577	efflux transmembrane transporter activity
M6D84_13375	COG1073	alpha beta
M6D84_13380	COG0657	acetylesterase activity
M6D84_13385	COG0076	glutamate decarboxylase activity
M6D84_13400	COG1523	belongs to the glycosyl hydrolase 13 family
M6D84_13405	COG3227	Zinc metalloprotease (Elastase)
M6D84_13410	COG0737	Belongs to the 5'-nucleotidase family
M6D84_13425	COG0201	protein transport
M6D84_13430	COG0697	spore germination
M6D84_13435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M6D84_13475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M6D84_13490	COG2959	enzyme of heme biosynthesis
M6D84_13530	COG1309	transcriptional regulator
M6D84_13560	COG3284	Transcriptional regulator
M6D84_13575	COG1349	DNA-binding transcription factor activity
M6D84_13590	COG1959	2 iron, 2 sulfur cluster binding
M6D84_13605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M6D84_13610	COG0508	dehydrogenase complex catalyzes the overall conversion of
M6D84_13615	COG0022	dehydrogenase e1 component
M6D84_13620	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M6D84_13630	COG1028	Short-chain dehydrogenase reductase Sdr
M6D84_13635	COG0456	acetyltransferase
M6D84_13635	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M6D84_13675	COG4176	ABC-type proline glycine betaine transport system permease component
M6D84_13680	COG0517	IMP dehydrogenase activity
M6D84_13680	COG4175	Glycine betaine
M6D84_13710	COG2153	protein acetylation
M6D84_13715	COG3397	chitin binding
M6D84_13720	COG1819	glycosyl
M6D84_13740	COG2205	protein histidine kinase activity
M6D84_13745	COG2226	methyltransferase
M6D84_13750	COG2315	Protein conserved in bacteria
M6D84_13795	COG3973	AAA domain
M6D84_13805	COG2105	PFAM AIG2 family protein
M6D84_13810	COG0514	ATP-dependent DNA helicase (RecQ)
M6D84_13845	COG4637	Psort location Cytoplasmic, score
M6D84_13860	COG3397	chitin binding
M6D84_13875	COG1162	GTPase activity
M6D84_13880	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M6D84_13885	COG1115	amino acid carrier protein
M6D84_13890	COG1012	belongs to the aldehyde dehydrogenase family
M6D84_13895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M6D84_13905	COG3938	Belongs to the proline racemase family
M6D84_13910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M6D84_13955	COG1078	dGTPase activity
M6D84_13960	COG0586	Pfam SNARE associated Golgi protein
M6D84_13970	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
M6D84_13980	COG4166	transmembrane transport
M6D84_13990	COG4948	Mandelate Racemase Muconate Lactonizing
M6D84_14005	COG0667	Aldo Keto reductase
M6D84_14050	COG3850	Histidine kinase
M6D84_14050	COG5002	protein histidine kinase activity
M6D84_14055	COG0745	RESPONSE REGULATOR receiver
M6D84_14095	COG1164	Oligoendopeptidase f
M6D84_14100	COG1307	EDD domain protein, DegV family
M6D84_14140	COG2814	Major facilitator Superfamily
M6D84_14150	COG1664	Polymer-forming cytoskeletal
M6D84_14155	COG0789	Transcriptional regulator
M6D84_14160	COG4533	DNA binding
M6D84_14165	COG2814	Major facilitator Superfamily
M6D84_14165	COG0477	Major facilitator Superfamily
M6D84_14185	COG2261	transglycosylase associated protein
M6D84_14235	COG0436	Aminotransferase
M6D84_14240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M6D84_14250	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M6D84_14290	COG0628	permease
M6D84_14305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M6D84_14310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M6D84_14315	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M6D84_14355	COG2746	aminoglycoside 3-N-acetyltransferase activity
M6D84_14365	COG0697	spore germination
M6D84_14375	COG2318	DinB family
M6D84_14395	COG4912	Dna alkylation repair
M6D84_14400	COG0346	lactoylglutathione lyase activity
M6D84_14415	COG0861	Integral membrane protein TerC family
M6D84_14420	COG1368	sulfuric ester hydrolase activity
M6D84_14425	COG0488	(ABC) transporter
M6D84_14430	COG1033	growth of symbiont in host cell
M6D84_14430	COG2409	Drug exporters of the RND superfamily
M6D84_14435	COG1309	transcriptional regulator
M6D84_14450	COG0287	Prephenate dehydrogenase
M6D84_14465	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M6D84_14465	COG1605	Chorismate mutase
M6D84_14510	COG1388	LysM domain
M6D84_14510	COG3584	3D domain protein
M6D84_14530	COG0277	FAD linked oxidase domain protein
M6D84_14535	COG0477	Major facilitator Superfamily
M6D84_14540	COG1309	transcriptional regulator
M6D84_14550	COG1595	DNA-templated transcription, initiation
M6D84_14580	COG1172	Belongs to the binding-protein-dependent transport system permease family
M6D84_14585	COG1172	Belongs to the binding-protein-dependent transport system permease family
M6D84_14595	COG2390	Transcriptional regulator
M6D84_14600	COG1070	Carbohydrate kinase
M6D84_14625	COG2329	Antibiotic biosynthesis monooxygenase
M6D84_14645	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M6D84_14660	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M6D84_14665	COG4187	Peptidase family M20/M25/M40
M6D84_14670	COG1414	Transcriptional regulator
M6D84_14675	COG0833	amino acid
M6D84_14685	COG3239	Fatty acid desaturase
M6D84_14695	COG2720	vancomycin resistance protein
M6D84_14700	COG1785	Belongs to the alkaline phosphatase family
M6D84_14710	COG3655	Transcriptional regulator
M6D84_14730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M6D84_14735	COG0346	lactoylglutathione lyase activity
M6D84_14760	COG0714	Associated with various cellular activities
M6D84_14790	COG0463	Glycosyl transferase, family 2
M6D84_14820	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M6D84_14825	COG0753	catalase activity
M6D84_14865	COG0714	Associated with various cellular activities
M6D84_14925	COG0778	Nitroreductase
M6D84_14930	COG1846	Transcriptional regulator
M6D84_14975	COG0456	acetyltransferase
M6D84_14990	COG0697	spore germination
M6D84_14995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M6D84_15010	COG0642	Histidine kinase
M6D84_15015	COG0745	RESPONSE REGULATOR receiver
M6D84_15020	COG0596	Alpha beta hydrolase
M6D84_15055	COG0730	response to heat
M6D84_15065	COG0833	amino acid
M6D84_15075	COG4335	DNA alkylation repair
M6D84_15085	COG5002	protein histidine kinase activity
M6D84_15090	COG0745	RESPONSE REGULATOR receiver
M6D84_15100	COG0577	efflux transmembrane transporter activity
M6D84_15100	COG1136	(ABC) transporter
M6D84_15130	COG0768	penicillin binding
M6D84_15160	COG1984	allophanate hydrolase subunit 2
M6D84_15165	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M6D84_15170	COG1414	Transcriptional regulator
M6D84_15185	COG0640	Transcriptional regulator
M6D84_15195	COG1960	acyl-CoA dehydrogenase activity
M6D84_15210	COG3314	Sporulation integral membrane protein YlbJ
M6D84_15230	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
M6D84_15255	COG0574	Belongs to the PEP-utilizing enzyme family
M6D84_15255	COG3848	Pyruvate phosphate dikinase
M6D84_15260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M6D84_15280	COG1063	alcohol dehydrogenase
M6D84_15285	COG1027	Aspartate ammonia-lyase
M6D84_15290	COG0252	asparaginase activity
M6D84_15295	COG1396	sequence-specific DNA binding
M6D84_15320	COG5002	protein histidine kinase activity
M6D84_15345	COG2207	Transcriptional regulator
M6D84_15360	COG0322	excinuclease ABC activity
M6D84_15365	COG0531	amino acid
M6D84_15370	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M6D84_15380	COG0531	amino acid
M6D84_15385	COG0697	spore germination
M6D84_15390	COG0784	Response regulator, receiver
M6D84_15395	COG4191	Histidine kinase
M6D84_15400	COG2066	Belongs to the glutaminase family
M6D84_15405	COG1115	amino acid carrier protein
M6D84_15430	COG0737	Belongs to the 5'-nucleotidase family
M6D84_15435	COG2267	carboxylic ester hydrolase activity
M6D84_15440	COG1335	isochorismatase
M6D84_15460	COG0583	DNA-binding transcription factor activity
M6D84_15465	COG1846	Transcriptional regulator
M6D84_15485	COG0598	Magnesium transport protein CorA
M6D84_15505	COG1073	alpha beta
M6D84_15525	COG0415	Belongs to the DNA photolyase family
M6D84_15535	COG2814	Major facilitator Superfamily
M6D84_15545	COG0657	acetylesterase activity
M6D84_15550	COG0288	reversible hydration of carbon dioxide
M6D84_15560	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M6D84_15565	COG5609	conserved protein (DUF2294)
M6D84_15575	COG0456	acetyltransferase
M6D84_15580	COG1575	Belongs to the MenA family. Type 1 subfamily
M6D84_15605	COG0798	PFAM Bile acid sodium symporter
M6D84_15610	COG0346	lactoylglutathione lyase activity
M6D84_15615	COG0640	Transcriptional regulator
M6D84_15625	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M6D84_15635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M6D84_15635	COG3320	Male sterility
M6D84_15640	COG1309	transcriptional regulator
M6D84_15655	COG0346	lactoylglutathione lyase activity
M6D84_15680	COG0745	RESPONSE REGULATOR receiver
M6D84_15685	COG5002	protein histidine kinase activity
M6D84_15685	COG3850	Histidine kinase
M6D84_15720	COG0277	FAD linked oxidase domain protein
M6D84_15730	COG1136	(ABC) transporter
M6D84_15770	COG2814	Major facilitator Superfamily
M6D84_15785	COG2515	1-aminocyclopropane-1-carboxylate deaminase
M6D84_15805	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
M6D84_15825	COG0577	efflux transmembrane transporter activity
M6D84_15845	COG5002	protein histidine kinase activity
M6D84_15845	COG3850	Histidine kinase
M6D84_15855	COG2364	Membrane
M6D84_15860	COG1846	Transcriptional regulator
M6D84_15865	COG0456	acetyltransferase
M6D84_15870	COG2808	Putative FMN-binding domain
M6D84_15875	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M6D84_15905	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M6D84_15945	COG3409	Peptidoglycan-binding domain 1 protein
M6D84_15945	COG5632	N-Acetylmuramoyl-L-alanine amidase
M6D84_15995	COG5444	nuclease activity
M6D84_16050	COG1876	peptidase activity
M6D84_16055	COG2843	Capsule synthesis protein
M6D84_16065	COG0477	Major facilitator Superfamily
M6D84_16080	COG1846	Transcriptional regulator
M6D84_16085	COG2814	Major facilitator Superfamily
M6D84_16095	COG2031	fatty acid transporter
M6D84_16105	COG2249	NAD(P)H dehydrogenase (quinone) activity
M6D84_16160	COG1288	antiporter activity
M6D84_16165	COG2356	endonuclease I
M6D84_16185	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M6D84_16205	COG1733	regulation of RNA biosynthetic process
M6D84_16210	COG0778	Nitroreductase
M6D84_16220	COG0469	pyruvate kinase activity
M6D84_16240	COG1028	Short-chain dehydrogenase reductase Sdr
M6D84_16250	COG1131	(ABC) transporter
M6D84_16275	COG1011	Hydrolase
M6D84_16280	COG2365	Tyrosine phosphatase family
M6D84_16315	COG0628	permease
M6D84_16345	COG0500	methyltransferase
M6D84_16385	COG1253	flavin adenine dinucleotide binding
M6D84_16390	COG0789	Transcriptional regulator
M6D84_16400	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M6D84_16425	COG0697	spore germination
M6D84_16435	COG1357	PFAM Pentapeptide repeats (8 copies)
M6D84_16440	COG3813	Protein conserved in bacteria
M6D84_16445	COG2706	6-phosphogluconolactonase activity
M6D84_16450	COG1070	Carbohydrate kinase
M6D84_16460	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M6D84_16465	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
M6D84_16470	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M6D84_16475	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M6D84_16510	COG0814	amino acid
M6D84_16540	COG2188	Transcriptional regulator
M6D84_16545	COG0673	inositol 2-dehydrogenase activity
M6D84_16565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M6D84_16590	COG0384	phenazine biosynthesis protein PhzF
M6D84_16600	COG0318	PFAM AMP-dependent synthetase and ligase
M6D84_16605	COG2249	NAD(P)H dehydrogenase (quinone) activity
M6D84_16610	COG1733	regulation of RNA biosynthetic process
M6D84_16635	COG1191	sigma factor activity
M6D84_16695	COG3209	COG3209 Rhs family protein
M6D84_16705	COG1151	hydroxylamine reductase activity
M6D84_16735	COG2072	flavoprotein involved in K transport
M6D84_16770	COG1113	amino acid transport
M6D84_16775	COG2814	Major facilitator Superfamily
M6D84_16810	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M6D84_16815	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M6D84_16825	COG1247	-acetyltransferase
M6D84_16830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M6D84_16835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M6D84_16840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M6D84_16845	COG3739	integral membrane protein
M6D84_16870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M6D84_16885	COG0583	DNA-binding transcription factor activity
M6D84_16905	COG1193	negative regulation of DNA recombination
M6D84_16915	COG2162	N-hydroxyarylamine O-acetyltransferase activity
M6D84_16920	COG1164	Oligoendopeptidase f
M6D84_16955	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M6D84_16980	COG0584	glycerophosphoryl diester phosphodiesterase
M6D84_16990	COG0640	Transcriptional regulator
M6D84_16995	COG0604	alcohol dehydrogenase
M6D84_17005	COG0457	Tetratricopeptide repeat
M6D84_17020	COG0277	FAD linked oxidase domain protein
M6D84_17045	COG1183	phosphatidylcholine synthase activity
M6D84_17050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M6D84_17050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M6D84_17055	COG1252	NADH dehydrogenase
M6D84_17065	COG0823	Involved in the tonB-independent uptake of proteins
M6D84_17070	COG3397	chitin binding
M6D84_17080	COG0697	spore germination
M6D84_17100	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M6D84_17110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M6D84_17120	COG0457	Tetratricopeptide repeat
M6D84_17180	COG0488	(ABC) transporter
M6D84_17210	COG3852	Histidine kinase
M6D84_17220	COG1285	pathogenesis
M6D84_17230	COG2514	catechol 2,3-dioxygenase activity
M6D84_17235	COG2720	vancomycin resistance protein
M6D84_17270	COG0716	FMN binding
M6D84_17280	COG0494	nUDIX hydrolase
M6D84_17300	COG1028	Short-chain dehydrogenase reductase Sdr
M6D84_17310	COG0165	Argininosuccinate lyase
M6D84_17325	COG4145	pantothenate transmembrane transporter activity
M6D84_17335	COG1012	belongs to the aldehyde dehydrogenase family
M6D84_17340	COG1028	Short-chain dehydrogenase reductase Sdr
M6D84_17350	COG1657	PFAM Prenyltransferase squalene oxidase
M6D84_17355	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
M6D84_17360	COG2962	Rard protein
M6D84_17365	COG3326	Membrane
M6D84_17380	COG0489	protein tyrosine kinase activity
M6D84_17390	COG0314	molybdopterin synthase activity
M6D84_17395	COG0303	'Molybdopterin
M6D84_17400	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M6D84_17405	COG2116	formate transmembrane transporter activity
M6D84_17415	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M6D84_17420	COG5609	conserved protein (DUF2294)
M6D84_17425	COG2427	Protein of unknown function (DUF1641)
M6D84_17430	COG3383	formate dehydrogenase (NAD+) activity
M6D84_17435	COG0697	spore germination
M6D84_17450	COG0531	amino acid
M6D84_17485	COG2226	methyltransferase
M6D84_17490	COG4166	transmembrane transport
M6D84_17495	COG4166	transmembrane transport
M6D84_17500	COG4166	transmembrane transport
M6D84_17505	COG1301	dicarboxylic acid transport
M6D84_17510	COG1316	TRANSCRIPTIONal
M6D84_17520	COG1595	DNA-templated transcription, initiation
M6D84_17530	COG1131	(ABC) transporter
M6D84_17540	COG0673	inositol 2-dehydrogenase activity
M6D84_17545	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M6D84_17550	COG0187	DNA topoisomerase II activity
M6D84_17555	COG1832	CoA-binding protein
M6D84_17560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M6D84_17565	COG0745	RESPONSE REGULATOR receiver
M6D84_17585	COG4841	protein insertion into membrane
M6D84_17590	COG0824	Thioesterase
M6D84_17620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M6D84_17635	COG1132	(ABC) transporter
M6D84_17640	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M6D84_17670	COG2211	Major facilitator Superfamily
M6D84_17680	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M6D84_17695	COG0183	Belongs to the thiolase family
M6D84_17700	COG0318	PFAM AMP-dependent synthetase and ligase
M6D84_17705	COG1268	BioY protein
M6D84_17710	COG0318	PFAM AMP-dependent synthetase and ligase
M6D84_17755	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M6D84_17765	COG5002	protein histidine kinase activity
M6D84_17770	COG0400	carboxylic ester hydrolase activity
M6D84_17775	COG0346	lactoylglutathione lyase activity
M6D84_17780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M6D84_17790	COG0069	glutamate synthase activity
M6D84_17795	COG1902	pentaerythritol trinitrate reductase activity
M6D84_17800	COG1329	Transcriptional regulator
M6D84_17805	COG0010	Belongs to the arginase family
M6D84_17855	COG4846	Membrane protein involved in cytochrome C biogenesis
M6D84_17860	COG0785	Cytochrome C biogenesis protein
M6D84_17870	COG1473	amidohydrolase
M6D84_17880	COG1131	(ABC) transporter
M6D84_17895	COG0583	DNA-binding transcription factor activity
M6D84_17905	COG1346	cytolysis
M6D84_17920	COG0730	response to heat
M6D84_17945	COG1132	(ABC) transporter
M6D84_17950	COG1132	(ABC) transporter
M6D84_17975	COG3639	organic phosphonate transmembrane transporter activity
M6D84_17985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M6D84_17990	COG0737	Belongs to the 5'-nucleotidase family
M6D84_18000	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M6D84_18020	COG1695	Transcriptional regulator
M6D84_18030	COG3409	Peptidoglycan-binding domain 1 protein
M6D84_18030	COG5632	N-Acetylmuramoyl-L-alanine amidase
M6D84_18030	COG1388	LysM domain
M6D84_18035	COG0739	heme binding
M6D84_18040	COG0741	lytic transglycosylase activity
M6D84_18070	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M6D84_18075	COG0174	glutamine synthetase
M6D84_18080	COG0789	Transcriptional regulator
M6D84_18085	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
M6D84_18090	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M6D84_18095	COG2860	membrane
M6D84_18105	COG0464	growth
M6D84_18135	COG3584	3D domain protein
M6D84_18135	COG1388	LysM domain
M6D84_18140	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M6D84_18140	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M6D84_18140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M6D84_18145	COG1105	Belongs to the carbohydrate kinase PfkB family
M6D84_18150	COG1349	DNA-binding transcription factor activity
M6D84_18155	COG1979	alcohol dehydrogenase
M6D84_18160	COG2322	membrane
M6D84_18170	COG1113	amino acid transport
M6D84_18180	COG1408	metallophosphoesterase
M6D84_18185	COG2116	formate transmembrane transporter activity
M6D84_18200	COG2217	Heavy metal translocating P-type atpase
M6D84_18205	COG2608	mercury ion transmembrane transporter activity
M6D84_18210	COG1937	Protein conserved in bacteria
M6D84_18220	COG2819	hydrolase of the alpha beta superfamily
M6D84_18225	COG1120	ATPase activity
M6D84_18230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M6D84_18235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M6D84_18240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M6D84_18250	COG2169	Transcriptional regulator
M6D84_18255	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M6D84_18260	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M6D84_18280	COG2267	carboxylic ester hydrolase activity
M6D84_18285	COG3300	MHYT domain
M6D84_18285	COG5001	Diguanylate cyclase
M6D84_18325	COG1346	cytolysis
M6D84_18335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M6D84_18345	COG2188	Transcriptional regulator
M6D84_18350	COG2723	6-phospho-beta-galactosidase activity
M6D84_18360	COG1404	Belongs to the peptidase S8 family
M6D84_18365	COG3773	Cell wall hydrolase
M6D84_18375	COG1368	sulfuric ester hydrolase activity
M6D84_18380	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M6D84_18405	COG4550	Control of competence regulator ComK, YlbF/YmcA
M6D84_18415	COG1013	pyruvate-flavodoxin oxidoreductase activity
M6D84_18420	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
M6D84_18420	COG0674	pyruvate-flavodoxin oxidoreductase activity
M6D84_18430	COG2359	stage V sporulation protein S
M6D84_18435	COG1692	metallophosphoesterase
M6D84_18455	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M6D84_18460	COG1426	Protein conserved in bacteria
M6D84_18475	COG0300	oxidoreductase activity
M6D84_18480	COG0612	Peptidase, M16
M6D84_18485	COG0612	Peptidase, M16
M6D84_18490	COG1079	Belongs to the binding-protein-dependent transport system permease family
M6D84_18495	COG4603	Belongs to the binding-protein-dependent transport system permease family
M6D84_18500	COG3845	ABC transporter
M6D84_18505	COG1744	ABC transporter substrate-binding protein PnrA-like
M6D84_18510	COG2188	Transcriptional regulator
M6D84_18530	COG0740	serine-type endopeptidase activity
M6D84_18535	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M6D84_18545	COG0527	aspartate kinase activity
M6D84_18550	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M6D84_18575	COG4824	toxin secretion phage lysis holin
M6D84_18695	COG0582	viral genome integration into host DNA
M6D84_18715	COG1192	Involved in chromosome partitioning
M6D84_18735	COG0305	Participates in initiation and elongation during chromosome replication
M6D84_18800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M6D84_18805	COG1873	PFAM PRC-barrel domain
M6D84_18810	COG0612	Peptidase, M16
M6D84_18815	COG0726	polysaccharide deacetylase
M6D84_18830	COG0196	riboflavin kinase activity
M6D84_18840	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M6D84_18845	COG1550	Protein conserved in bacteria
M6D84_18855	COG1358	cellular component organization or biogenesis
M6D84_18860	COG2740	Nucleic-acid-binding protein implicated in transcription termination
M6D84_18865	COG0195	Participates in both transcription termination and antitermination
M6D84_18885	COG0750	zinc metalloprotease
M6D84_18895	COG4589	Belongs to the CDS family
M6D84_18940	COG4974	Belongs to the 'phage' integrase family
M6D84_18950	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M6D84_18955	COG0758	DNA mediated transformation
M6D84_18960	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M6D84_19000	COG1837	Belongs to the UPF0109 family
M6D84_19010	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M6D84_19020	COG0552	protein localization to endoplasmic reticulum
M6D84_19025	COG1196	nuclear chromosome segregation
M6D84_19035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M6D84_19040	COG1028	Short-chain dehydrogenase reductase Sdr
M6D84_19045	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M6D84_19060	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M6D84_19065	COG1461	Dihydroxyacetone kinase
M6D84_19070	COG1302	Protein conserved in bacteria
M6D84_19085	COG1564	THIamine pyrophosphokinase
M6D84_19090	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M6D84_19100	COG2815	serine threonine protein kinase
M6D84_19100	COG0515	serine threonine protein kinase
M6D84_19105	COG0631	protein serine/threonine phosphatase activity
M6D84_19115	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M6D84_19115	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M6D84_19130	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M6D84_19135	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M6D84_19155	COG1561	YicC-like family, N-terminal region
M6D84_19160	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M6D84_19170	COG0006	proline dipeptidase activity
M6D84_19185	COG3069	C4-dicarboxylate transmembrane transporter activity
M6D84_19245	COG0564	pseudouridine synthase activity
M6D84_19265	COG3599	regulation of cell shape
M6D84_19270	COG2302	S4 RNA-binding domain
M6D84_19275	COG0762	integral membrane protein
M6D84_19285	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M6D84_19295	COG1873	PFAM PRC-barrel domain
M6D84_19300	COG1191	sigma factor activity
M6D84_19305	COG1191	sigma factor activity
M6D84_19315	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M6D84_19320	COG0849	cell division
M6D84_19340	COG0772	Belongs to the SEDS family
M6D84_19360	COG0768	penicillin binding
M6D84_19365	COG0768	penicillin binding
M6D84_19385	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M6D84_19400	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M6D84_19405	COG1399	metal-binding, possibly nucleic acid-binding protein
M6D84_19415	COG3480	Lon protease (S16) C-terminal proteolytic domain
M6D84_19420	COG1752	Esterase of the alpha-beta hydrolase superfamily
M6D84_19425	COG3314	Sporulation integral membrane protein YlbJ
M6D84_19435	COG0742	ribosomal rna small subunit methyltransferase
M6D84_19450	COG3679	Belongs to the UPF0342 family
M6D84_19455	COG0406	alpha-ribazole phosphatase activity
M6D84_19470	COG2340	Cysteine-rich secretory protein family
M6D84_19485	COG3336	cytochrome c oxidase
M6D84_19520	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
M6D84_19525	COG0772	Belongs to the SEDS family
M6D84_19535	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M6D84_19540	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M6D84_19550	COG4896	Protein conserved in bacteria
M6D84_19565	COG1217	gtp-binding protein TYPA
M6D84_19575	COG0483	inositol monophosphate 1-phosphatase activity
M6D84_19595	COG1982	Orn Lys Arg decarboxylase major
M6D84_19645	COG0022	dehydrogenase e1 component
M6D84_19650	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M6D84_19665	COG0561	phosphatase activity
M6D84_19675	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M6D84_19680	COG0569	domain protein
M6D84_19700	COG0583	DNA-binding transcription factor activity
M6D84_19705	COG0517	IMP dehydrogenase activity
M6D84_19715	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
M6D84_19725	COG4703	Protein of unknown function (DUF1797)
M6D84_19740	COG2200	EAL domain
M6D84_19745	COG1028	Short-chain dehydrogenase reductase Sdr
M6D84_19750	COG1408	metallophosphoesterase
M6D84_19795	COG2814	Major facilitator Superfamily
M6D84_19815	COG3209	COG3209 Rhs family protein
M6D84_19825	COG2205	protein histidine kinase activity
M6D84_19835	COG0436	Aminotransferase
M6D84_19840	COG1609	Transcriptional regulator
M6D84_19845	COG3833	ABC-type maltose transport systems, permease component
M6D84_19850	COG1175	transmembrane transport
M6D84_19855	COG2182	Extracellular solute-binding protein
M6D84_19865	COG0366	Alpha amylase catalytic
M6D84_19870	COG3842	ATPase activity
M6D84_19910	COG0183	Belongs to the thiolase family
M6D84_19945	COG1695	Transcriptional regulator
M6D84_19950	COG1028	Short-chain dehydrogenase reductase Sdr
M6D84_19970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M6D84_19975	COG0436	Aminotransferase
M6D84_20010	COG2084	Dehydrogenase
M6D84_20020	COG2199	diguanylate cyclase activity
M6D84_20025	COG0778	Nitroreductase
M6D84_20050	COG1263	PTS System
M6D84_20050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M6D84_20050	COG2190	(PTS) system
M6D84_20055	COG3711	transcriptional antiterminator
M6D84_20065	COG2188	Transcriptional regulator
M6D84_20075	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M6D84_20100	COG1547	Domain of unknown function (DUF309)
M6D84_20105	COG0456	acetyltransferase
M6D84_20110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M6D84_20115	COG4086	secreted protein
M6D84_20120	COG0561	phosphatase activity
M6D84_20125	COG0697	spore germination
M6D84_20140	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M6D84_20165	COG0733	neurotransmitter:sodium symporter activity
M6D84_20185	COG1686	Belongs to the peptidase S11 family
M6D84_20190	COG1725	Transcriptional regulator
M6D84_20195	COG1131	(ABC) transporter
M6D84_20215	COG1846	Transcriptional regulator
M6D84_20230	COG0598	Magnesium transport protein CorA
M6D84_20255	COG4974	Belongs to the 'phage' integrase family
M6D84_20265	COG0735	belongs to the Fur family
M6D84_20270	COG1300	Membrane
M6D84_20290	COG0667	Aldo Keto reductase
M6D84_20295	COG0656	L-ascorbic acid biosynthetic process
M6D84_20300	COG0456	acetyltransferase
M6D84_20300	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M6D84_20310	COG0737	Belongs to the 5'-nucleotidase family
M6D84_20310	COG1525	nuclease
M6D84_20310	COG4085	toxin activity
M6D84_20320	COG0596	Alpha beta hydrolase
M6D84_20325	COG2056	Na+-H+ antiporter family
M6D84_20330	COG1609	Transcriptional regulator
M6D84_20335	COG0456	acetyltransferase
M6D84_20340	COG1073	alpha beta
M6D84_20355	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M6D84_20355	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M6D84_20360	COG0307	riboflavin synthase, alpha
M6D84_20390	COG1073	alpha beta
M6D84_20390	COG2226	methyltransferase
M6D84_20405	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M6D84_20415	COG1757	Na H antiporter
M6D84_20420	COG0737	Belongs to the 5'-nucleotidase family
M6D84_20430	COG1522	sequence-specific DNA binding
M6D84_20475	COG0300	oxidoreductase activity
M6D84_20480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M6D84_20485	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M6D84_20490	COG1760	l-serine dehydratase
M6D84_20495	COG1760	l-serine dehydratase
M6D84_20525	COG1285	pathogenesis
M6D84_20535	COG2195	Cleaves the N-terminal amino acid of tripeptides
M6D84_20540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M6D84_20555	COG1376	ErfK ybiS ycfS ynhG family protein
M6D84_20560	COG4129	membrane
M6D84_20565	COG1126	abc transporter atp-binding protein
M6D84_20570	COG0765	amino acid transport
M6D84_20575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M6D84_20590	COG2816	NAD+ diphosphatase activity
M6D84_20595	COG2323	membrane
M6D84_20600	COG0772	Belongs to the SEDS family
M6D84_20605	COG0508	dehydrogenase complex catalyzes the overall conversion of
M6D84_20610	COG0022	dehydrogenase e1 component
M6D84_20615	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M6D84_20620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M6D84_20635	COG0280	phosphate acetyltransferase
M6D84_20640	COG3290	protein histidine kinase activity
M6D84_20640	COG3829	transcription factor binding
M6D84_20650	COG0584	glycerophosphoryl diester phosphodiesterase
M6D84_20655	COG3093	addiction module antidote protein HigA
M6D84_20670	COG0750	zinc metalloprotease
M6D84_20675	COG0497	DNA recombination
M6D84_20685	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
M6D84_20695	COG0142	geranyltranstransferase activity
M6D84_20720	COG1302	Protein conserved in bacteria
M6D84_20725	COG0439	Biotin carboxylase
M6D84_20730	COG0511	ligase activity, forming carbon-carbon bonds
M6D84_20775	COG3854	ATPases associated with a variety of cellular activities
M6D84_20800	COG0006	proline dipeptidase activity
M6D84_20815	COG3872	metal-dependent enzyme
M6D84_20825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M6D84_20840	COG1695	Transcriptional regulator
M6D84_20860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M6D84_20870	COG1609	Transcriptional regulator
M6D84_20880	COG2076	Multidrug Resistance protein
M6D84_20885	COG2076	Multidrug Resistance protein
M6D84_20915	COG1131	(ABC) transporter
M6D84_20920	COG1725	Transcriptional regulator
M6D84_20950	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M6D84_21015	COG1459	type II secretion system
M6D84_21020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M6D84_21075	COG0646	methionine synthase
M6D84_21075	COG1410	methionine synthase
M6D84_21080	COG0646	methionine synthase
M6D84_21080	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M6D84_21085	COG0626	cystathionine gamma-synthase activity
M6D84_21090	COG0626	cystathionine gamma-synthase activity
M6D84_21110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M6D84_21120	COG1940	carbohydrate kinase activity
M6D84_21125	COG4483	Protein conserved in bacteria
M6D84_21130	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M6D84_21135	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M6D84_21140	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M6D84_21145	COG0704	Plays a role in the regulation of phosphate uptake
M6D84_21155	COG0573	inorganic phosphate transmembrane transporter activity
M6D84_21160	COG0573	inorganic phosphate transmembrane transporter activity
M6D84_21165	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M6D84_21170	COG0768	penicillin binding
M6D84_21180	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M6D84_21190	COG5521	maltodextrose utilization protein MalA
M6D84_21205	COG0735	belongs to the Fur family
M6D84_21210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M6D84_21215	COG1121	(ABC) transporter
M6D84_21220	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M6D84_21250	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M6D84_21255	COG2384	SAM-dependent methyltransferase
M6D84_21265	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M6D84_21270	COG0358	DNA primase activity
M6D84_21285	COG0517	IMP dehydrogenase activity
M6D84_21300	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M6D84_21305	COG0295	cytidine deaminase activity
M6D84_21310	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M6D84_21320	COG1480	7TM receptor with intracellular HD hydrolase
M6D84_21325	COG1702	phosphate starvation-inducible protein PhoH
M6D84_21345	COG1610	YqeY-like protein
M6D84_21350	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M6D84_21355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M6D84_21360	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M6D84_21390	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M6D84_21395	COG1733	regulation of RNA biosynthetic process
M6D84_21420	COG1466	dna polymerase III delta subunit
M6D84_21430	COG2333	competence protein COMEC
M6D84_21430	COG0658	competence protein
M6D84_21435	COG2131	deaminase
M6D84_21440	COG1555	photosystem II stabilization
M6D84_21440	COG1596	polysaccharide export
M6D84_21445	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M6D84_21450	COG2226	methyltransferase
M6D84_21455	COG0799	negative regulation of ribosome biogenesis
M6D84_21460	COG1713	HD superfamily hydrolase involved in NAD metabolism
M6D84_21470	COG1534	Rna-binding protein
M6D84_21480	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M6D84_21485	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
M6D84_21520	COG0778	Nitroreductase
M6D84_21525	COG2357	RelA SpoT domain protein
M6D84_21535	COG1785	Belongs to the alkaline phosphatase family
M6D84_21545	COG2267	carboxylic ester hydrolase activity
M6D84_21580	COG1404	Belongs to the peptidase S8 family
M6D84_21585	COG3186	Phenylalanine-4-hydroxylase
M6D84_21595	COG2514	catechol 2,3-dioxygenase activity
M6D84_21600	COG2259	Doxx family
M6D84_21640	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M6D84_21650	COG1012	belongs to the aldehyde dehydrogenase family
M6D84_21650	COG1454	alcohol dehydrogenase
M6D84_21655	COG0626	cystathionine gamma-synthase activity
M6D84_21660	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M6D84_21685	COG0768	penicillin binding
M6D84_21705	COG0826	peptidase U32
M6D84_21710	COG0826	peptidase U32
M6D84_21715	COG4122	O-methyltransferase activity
M6D84_21720	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M6D84_21750	COG0628	permease
M6D84_21770	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M6D84_21785	COG1104	cysteine desulfurase activity
M6D84_21790	COG1959	2 iron, 2 sulfur cluster binding
M6D84_21795	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M6D84_21805	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M6D84_21830	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M6D84_21840	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M6D84_21840	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
M6D84_21845	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M6D84_21850	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M6D84_21850	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M6D84_21860	COG2244	polysaccharide biosynthetic process
M6D84_21865	COG2323	membrane
M6D84_21875	COG1862	Preprotein translocase
M6D84_21905	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
M6D84_21935	COG0157	Belongs to the NadC ModD family
M6D84_21940	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M6D84_21945	COG1104	cysteine desulfurase activity
M6D84_21950	COG1827	regulation of RNA biosynthetic process
M6D84_21955	COG2258	MOSC domain
M6D84_21960	COG0077	Prephenate dehydratase
M6D84_21965	COG0577	efflux transmembrane transporter activity
M6D84_21970	COG0577	efflux transmembrane transporter activity
M6D84_21975	COG1136	(ABC) transporter
M6D84_21980	COG5002	protein histidine kinase activity
M6D84_21985	COG0745	RESPONSE REGULATOR receiver
M6D84_21995	COG3290	protein histidine kinase activity
M6D84_22005	COG2868	ribosomal protein
M6D84_22015	COG1530	ribonuclease E activity
M6D84_22020	COG1994	Peptidase M50
M6D84_22025	COG0739	heme binding
M6D84_22030	COG2894	cell division
M6D84_22050	COG1077	Cell shape determining protein MreB Mrl
M6D84_22070	COG0285	dihydrofolate synthase activity
M6D84_22085	COG1388	LysM domain
M6D84_22095	COG0113	porphobilinogen synthase activity
M6D84_22100	COG1587	Uroporphyrinogen-III synthase
M6D84_22110	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M6D84_22120	COG1846	Transcriptional regulator
M6D84_22125	COG1764	response to oxidative stress
M6D84_22140	COG1067	ATP-dependent peptidase activity
M6D84_22140	COG0470	DNA polymerase III
M6D84_22185	COG0622	Phosphoesterase
M6D84_22200	COG5401	PFAM Sporulation and spore germination
M6D84_22225	COG1309	transcriptional regulator
M6D84_22235	COG2197	response regulator
M6D84_22240	COG2233	PERMEase
M6D84_22245	COG0402	S-adenosylhomocysteine deaminase activity
M6D84_22250	COG1983	PspC domain protein
M6D84_22255	COG1396	sequence-specific DNA binding
M6D84_22260	COG0697	spore germination
M6D84_22270	COG1959	2 iron, 2 sulfur cluster binding
M6D84_22275	COG1668	transmembrane transport
M6D84_22280	COG4152	abc transporter atp-binding protein
M6D84_22285	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
M6D84_22290	COG1360	Flagellar Motor Protein
M6D84_22295	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M6D84_22300	COG1876	peptidase activity
M6D84_22305	COG0824	Thioesterase
M6D84_22310	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M6D84_22315	COG1053	succinate dehydrogenase
M6D84_22320	COG2009	succinate dehydrogenase
M6D84_22325	COG1719	4-vinyl reductase, 4VR
M6D84_22335	COG3118	belongs to the thioredoxin family
M6D84_22340	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M6D84_22345	COG2086	electron transfer activity
M6D84_22350	COG1024	Enoyl-CoA hydratase
M6D84_22355	COG1309	transcriptional regulator
M6D84_22360	COG0318	PFAM AMP-dependent synthetase and ligase
M6D84_22385	COG2318	DinB family
M6D84_22410	COG1131	(ABC) transporter
M6D84_22415	COG2205	protein histidine kinase activity
M6D84_22420	COG0745	RESPONSE REGULATOR receiver
M6D84_22430	COG4895	conserved protein (DUF2196)
M6D84_22435	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M6D84_22445	COG4509	Sortase family
M6D84_22450	COG1120	ATPase activity
M6D84_22465	COG5386	Cell surface protein
M6D84_22475	COG5386	Cell surface protein
M6D84_22480	COG1114	Component of the transport system for branched-chain amino acids
M6D84_22485	COG1187	pseudouridine synthase activity
M6D84_22495	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M6D84_22495	COG1796	DNA polymerase
M6D84_22500	COG1286	toxin biosynthetic process
M6D84_22545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M6D84_22555	COG1418	mRNA catabolic process
M6D84_22565	COG2814	Major facilitator Superfamily
M6D84_22570	COG1566	PFAM secretion protein HlyD family protein
M6D84_22575	COG1309	transcriptional regulator
M6D84_22580	COG1363	Peptidase, m42
M6D84_22605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M6D84_22620	COG1484	DNA-dependent DNA replication
M6D84_22625	COG3611	Membrane attachment protein
M6D84_22635	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
M6D84_22640	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M6D84_22650	COG1971	Probably functions as a manganese efflux pump
M6D84_22660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M6D84_22660	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M6D84_22665	COG5002	protein histidine kinase activity
M6D84_22670	COG0745	RESPONSE REGULATOR receiver
M6D84_22690	COG0538	isocitrate dehydrogenase activity
M6D84_22695	COG0372	Belongs to the citrate synthase family
M6D84_22705	COG0628	permease
M6D84_22710	COG3030	protein affecting phage T7 exclusion by the F plasmid
M6D84_22735	COG1725	Transcriptional regulator
M6D84_22740	COG0281	malic enzyme
M6D84_22745	COG0587	DNA-directed DNA polymerase activity
M6D84_22760	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M6D84_22775	COG4109	DRTGG domain
M6D84_22790	COG0006	proline dipeptidase activity
M6D84_22830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M6D84_22835	COG0662	Cupin 2, conserved barrel domain protein
M6D84_22850	COG1028	Short-chain dehydrogenase reductase Sdr
M6D84_22855	COG0589	response to stress
M6D84_22895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M6D84_22920	COG0827	DNA restriction-modification system
M6D84_22925	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M6D84_22930	COG3874	Sporulation protein YtfJ
M6D84_22945	COG1574	metal-dependent hydrolase with the TIM-barrel fold
M6D84_22955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M6D84_22970	COG1104	cysteine desulfurase activity
M6D84_22980	COG0583	DNA-binding transcription factor activity
M6D84_22985	COG0697	spore germination
M6D84_22990	COG1309	transcriptional regulator
M6D84_22995	COG1956	GAF domain-containing protein
M6D84_23000	COG0626	cystathionine gamma-synthase activity
M6D84_23050	COG0110	maltose O-acetyltransferase activity
M6D84_23055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M6D84_23060	COG0454	-acetyltransferase
M6D84_23065	COG0517	IMP dehydrogenase activity
M6D84_23070	COG0123	including yeast histone deacetylase and acetoin utilization protein
M6D84_23085	COG0745	RESPONSE REGULATOR receiver
M6D84_23095	COG0666	response to abiotic stimulus
M6D84_23130	COG1609	Transcriptional regulator
M6D84_23135	COG1605	Chorismate mutase
M6D84_23135	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M6D84_23140	COG4851	CamS sex pheromone cAM373 precursor
M6D84_23155	COG2309	aminopeptidase activity
M6D84_23170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M6D84_23185	COG1674	ftsk spoiiie
M6D84_23190	COG1388	LysM domain
M6D84_23190	COG0860	N-Acetylmuramoyl-L-alanine amidase
M6D84_23200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M6D84_23210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M6D84_23215	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
M6D84_23220	COG1363	Peptidase, m42
M6D84_23230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M6D84_23245	COG0510	thiamine kinase activity
M6D84_23250	COG1523	belongs to the glycosyl hydrolase 13 family
M6D84_23260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M6D84_23265	COG1349	DNA-binding transcription factor activity
M6D84_23270	COG1187	pseudouridine synthase activity
M6D84_23275	COG2244	polysaccharide biosynthetic process
M6D84_23280	COG2081	HI0933 family
M6D84_23285	COG2814	Major facilitator Superfamily
M6D84_23295	COG3832	glyoxalase III activity
M6D84_23315	COG1329	Transcriptional regulator
M6D84_23340	COG0314	molybdopterin synthase activity
M6D84_23345	COG1763	Mo-molybdopterin cofactor biosynthetic process
M6D84_23350	COG0303	'Molybdopterin
M6D84_23360	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M6D84_23365	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M6D84_23385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M6D84_23395	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M6D84_23435	COG2814	Major facilitator Superfamily
M6D84_23440	COG0475	glutathione-regulated potassium exporter activity
M6D84_23445	COG0490	domain, Protein
M6D84_23450	COG0582	viral genome integration into host DNA
M6D84_23460	COG1136	(ABC) transporter
M6D84_23480	COG1242	4 iron, 4 sulfur cluster binding
M6D84_23485	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
M6D84_23490	COG1794	racemase activity, acting on amino acids and derivatives
M6D84_23505	COG2267	carboxylic ester hydrolase activity
M6D84_23510	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M6D84_23515	COG0671	phosphoesterase, PA-phosphatase related
M6D84_23520	COG0438	transferase activity, transferring glycosyl groups
M6D84_23590	COG5002	protein histidine kinase activity
M6D84_23595	COG3852	Histidine kinase
M6D84_23600	COG0753	catalase activity
M6D84_23610	COG2267	carboxylic ester hydrolase activity
M6D84_23615	COG1368	sulfuric ester hydrolase activity
M6D84_23640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M6D84_23645	COG1116	anion transmembrane transporter activity
M6D84_23650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M6D84_23675	COG0494	nUDIX hydrolase
M6D84_23705	COG1854	S-ribosylhomocysteine lyase activity
M6D84_23715	COG0288	reversible hydration of carbon dioxide
M6D84_23720	COG1271	oxidase subunit
M6D84_23725	COG1294	oxidase, subunit
M6D84_23740	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M6D84_23765	COG1842	Phage shock protein A
M6D84_23795	COG5002	protein histidine kinase activity
M6D84_23800	COG0745	RESPONSE REGULATOR receiver
M6D84_23825	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M6D84_23830	COG1597	lipid kinase activity
M6D84_23875	COG0586	Pfam SNARE associated Golgi protein
M6D84_23885	COG0577	efflux transmembrane transporter activity
M6D84_23890	COG1136	(ABC) transporter
M6D84_23895	COG2207	Transcriptional regulator
M6D84_23895	COG3708	Transcriptional regulator
M6D84_23915	COG5658	integral membrane protein
M6D84_23920	COG0640	Transcriptional regulator
M6D84_23925	COG0745	RESPONSE REGULATOR receiver
M6D84_23930	COG2205	protein histidine kinase activity
M6D84_23935	COG0577	efflux transmembrane transporter activity
M6D84_23940	COG0577	efflux transmembrane transporter activity
M6D84_23945	COG1136	(ABC) transporter
M6D84_23950	COG0577	efflux transmembrane transporter activity
M6D84_23965	COG2188	Transcriptional regulator
M6D84_23985	COG3964	amidohydrolase
M6D84_24005	COG4948	Mandelate Racemase Muconate Lactonizing
M6D84_24015	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M6D84_24020	COG0596	Alpha beta hydrolase
M6D84_24030	COG1169	isochorismate synthase
M6D84_24035	COG1575	Belongs to the MenA family. Type 1 subfamily
M6D84_24040	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M6D84_24065	COG0058	SHG alpha-glucan phosphorylase activity
M6D84_24075	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M6D84_24190	COG0544	peptidyl-prolyl cis-trans isomerase activity
M6D84_24225	COG1285	pathogenesis
M6D84_24230	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M6D84_24245	COG2155	Conserved Protein
M6D84_24250	COG1098	S1 RNA binding domain
M6D84_24255	COG0436	Aminotransferase
M6D84_24260	COG1522	sequence-specific DNA binding
M6D84_24265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M6D84_24270	COG2267	carboxylic ester hydrolase activity
M6D84_24280	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M6D84_24300	COG5018	Exonuclease
M6D84_24305	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M6D84_24325	COG2050	protein possibly involved in aromatic compounds catabolism
M6D84_24335	COG1268	BioY protein
M6D84_24340	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M6D84_24345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M6D84_24365	COG2076	Multidrug Resistance protein
M6D84_24370	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M6D84_24380	COG3584	3D domain protein
M6D84_24395	COG1252	NADH dehydrogenase
M6D84_24410	COG3708	Transcriptional regulator
M6D84_24425	COG1683	Conserved Protein
M6D84_24445	COG0316	Belongs to the HesB IscA family
M6D84_24460	COG1252	NADH dehydrogenase
M6D84_24470	COG2274	protein secretion by the type I secretion system
M6D84_24475	COG0390	transport system, permease component
M6D84_24480	COG2824	Alkylphosphonate utilization operon protein PhnA
M6D84_24505	COG4837	Protein of unknown function (DUF1462)
M6D84_24510	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M6D84_24520	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M6D84_24525	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M6D84_24545	COG1358	cellular component organization or biogenesis
M6D84_24560	COG0577	efflux transmembrane transporter activity
M6D84_24560	COG1136	(ABC) transporter
M6D84_24565	COG2249	NAD(P)H dehydrogenase (quinone) activity
M6D84_24575	COG0647	UMP catabolic process
M6D84_24585	COG2445	Protein of unknown function DUF86
M6D84_24590	COG1494	fructose-1,6-bisphosphatase
M6D84_24610	COG4470	Protein conserved in bacteria
M6D84_24620	COG0789	Transcriptional regulator
M6D84_24625	COG4377	Putative membrane peptidase family (DUF2324)
M6D84_24650	COG0739	heme binding
M6D84_24660	COG3377	Domain of unknown function (DUF1805)
M6D84_24665	COG0737	Belongs to the 5'-nucleotidase family
M6D84_24670	COG0719	Fe-S assembly protein
M6D84_24675	COG0822	iron-sulfur transferase activity
M6D84_24680	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M6D84_24685	COG0719	Fe-S assembly protein
M6D84_24690	COG0396	ATPase activity
M6D84_24695	COG1464	Belongs to the NlpA lipoprotein family
M6D84_24700	COG1464	Belongs to the NlpA lipoprotein family
M6D84_24705	COG2011	ABC-type metal ion transport system permease component
M6D84_24720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M6D84_24725	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M6D84_24740	COG1393	Belongs to the ArsC family
M6D84_24780	COG1309	transcriptional regulator
M6D84_24785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M6D84_24790	COG1960	acyl-CoA dehydrogenase activity
M6D84_24795	COG0183	Belongs to the thiolase family
M6D84_24800	COG1024	Enoyl-CoA hydratase
M6D84_24800	COG1250	3-hydroxyacyl-CoA dehydrogenase
M6D84_24810	COG1686	Belongs to the peptidase S11 family
M6D84_24825	COG0011	TIGRFAM Protein of
M6D84_24830	COG0840	transmembrane signaling receptor activity
M6D84_24845	COG2814	Major facilitator Superfamily
M6D84_24850	COG0531	amino acid
M6D84_24875	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M6D84_24910	COG0586	Pfam SNARE associated Golgi protein
M6D84_24920	COG1376	ErfK ybiS ycfS ynhG family protein
M6D84_24925	COG0745	RESPONSE REGULATOR receiver
M6D84_24930	COG5002	protein histidine kinase activity
M6D84_24960	COG0840	transmembrane signaling receptor activity
M6D84_24965	COG2151	metal-sulfur cluster biosynthetic enzyme
M6D84_24970	COG3227	Zinc metalloprotease (Elastase)
M6D84_24975	COG1741	Belongs to the pirin family
M6D84_24990	COG0475	glutathione-regulated potassium exporter activity
M6D84_24995	COG0490	domain, Protein
M6D84_25000	COG1115	amino acid carrier protein
M6D84_25005	COG0783	Belongs to the Dps family
M6D84_25020	COG1611	Belongs to the LOG family
M6D84_25030	COG1528	Iron-storage protein
M6D84_25040	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M6D84_25045	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M6D84_25050	COG1115	amino acid carrier protein
M6D84_25055	COG1115	amino acid carrier protein
M6D84_25060	COG2910	NAD(P)H-binding
M6D84_25075	COG0656	L-ascorbic acid biosynthetic process
M6D84_25080	COG2814	Major facilitator Superfamily
M6D84_25085	COG1733	regulation of RNA biosynthetic process
M6D84_25095	COG1252	NADH dehydrogenase
M6D84_25150	COG0488	(ABC) transporter
M6D84_25155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M6D84_25200	COG0745	RESPONSE REGULATOR receiver
M6D84_25215	COG0557	exoribonuclease II activity
M6D84_25220	COG1647	Serine aminopeptidase, S33
M6D84_25225	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M6D84_25230	COG1346	cytolysis
M6D84_25265	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M6D84_25280	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M6D84_25285	COG1668	transmembrane transport
M6D84_25290	COG4152	abc transporter atp-binding protein
M6D84_25295	COG4585	Histidine kinase
M6D84_25325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M6D84_25340	COG2323	membrane
M6D84_25350	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M6D84_25360	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M6D84_25370	COG1051	belongs to the nudix hydrolase family
M6D84_25380	COG0492	ferredoxin-NADP+ reductase activity
M6D84_25385	COG0457	Tetratricopeptide repeat
M6D84_25390	COG0110	maltose O-acetyltransferase activity
M6D84_25410	COG1950	PFAM Membrane protein of
M6D84_25420	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M6D84_25425	COG0556	nucleotide-excision repair
M6D84_25440	COG0789	Transcriptional regulator
M6D84_25470	COG0583	DNA-binding transcription factor activity
M6D84_25480	COG0655	NAD(P)H dehydrogenase (quinone) activity
M6D84_25485	COG0488	(ABC) transporter
M6D84_25495	COG1132	(ABC) transporter
M6D84_25500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M6D84_25505	COG3409	Peptidoglycan-binding domain 1 protein
M6D84_25505	COG0793	Belongs to the peptidase S41A family
M6D84_25510	COG2177	Part of the ABC transporter FtsEX involved in
M6D84_25515	COG2884	Cell division ATP-binding protein ftsE
M6D84_25540	COG1131	(ABC) transporter
M6D84_25570	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M6D84_25575	COG1278	Cold shock
M6D84_25580	COG1040	competence protein
M6D84_25585	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
M6D84_25590	COG0791	NLP P60 protein
M6D84_25590	COG1388	LysM domain
M6D84_25595	COG1733	regulation of RNA biosynthetic process
M6D84_25600	COG1307	EDD domain protein, DegV family
M6D84_25605	COG1739	Uncharacterized protein family UPF0029
M6D84_25610	COG1316	TRANSCRIPTIONal
M6D84_25615	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M6D84_25620	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M6D84_25625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M6D84_25635	COG3933	PFAM sigma-54 factor interaction domain-containing protein
M6D84_25635	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M6D84_25655	COG1486	melibiose metabolic process
M6D84_25660	COG1447	Phosphotransferase system cellobiose-specific component IIA
M6D84_25665	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M6D84_25685	COG1447	Phosphotransferase system cellobiose-specific component IIA
M6D84_25695	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M6D84_25700	COG1301	dicarboxylic acid transport
M6D84_25715	COG1511	domain protein
M6D84_25720	COG0583	DNA-binding transcription factor activity
M6D84_25725	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
M6D84_25735	COG1271	oxidase subunit
M6D84_25740	COG1294	oxidase, subunit
M6D84_25745	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M6D84_25770	COG1620	l-lactate permease
M6D84_25780	COG2389	metal-binding protein
M6D84_25790	COG1368	sulfuric ester hydrolase activity
M6D84_25800	COG0791	NLP P60 protein
M6D84_25800	COG1388	LysM domain
M6D84_25805	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M6D84_25815	COG1215	transferase activity, transferring glycosyl groups
M6D84_25820	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M6D84_25825	COG3584	3D domain protein
M6D84_25825	COG1388	LysM domain
M6D84_25850	COG4715	Zinc finger, swim domain protein
M6D84_25855	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M6D84_25895	COG0577	efflux transmembrane transporter activity
M6D84_25900	COG1136	(ABC) transporter
M6D84_25925	COG5002	protein histidine kinase activity
M6D84_25930	COG0745	RESPONSE REGULATOR receiver
M6D84_25935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M6D84_25945	COG1316	TRANSCRIPTIONal
M6D84_25955	COG0438	transferase activity, transferring glycosyl groups
M6D84_25960	COG0463	Glycosyl transferase, family 2
M6D84_25960	COG1216	Glycosyl transferase, family 2
M6D84_25995	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M6D84_26000	COG4464	protein tyrosine phosphatase activity
M6D84_26005	COG0489	protein tyrosine kinase activity
M6D84_26010	COG3944	biosynthesis protein
M6D84_26015	COG0489	protein tyrosine kinase activity
M6D84_26030	COG1609	Transcriptional regulator
M6D84_26040	COG0739	heme binding
M6D84_26055	COG3279	Response regulator of the LytR AlgR family
M6D84_26060	COG2385	sporulation resulting in formation of a cellular spore
M6D84_26075	COG4836	Membrane
M6D84_26085	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M6D84_26090	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M6D84_26100	COG0839	Belongs to the complex I subunit 6 family
M6D84_26120	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M6D84_26135	COG5001	Diguanylate cyclase
M6D84_26135	COG3300	MHYT domain
M6D84_26185	COG0356	it plays a direct role in the translocation of protons across the membrane
M6D84_26220	COG0698	ribose 5-phosphate isomerase
M6D84_26235	COG2259	Doxx family
M6D84_26240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M6D84_26255	COG0009	L-threonylcarbamoyladenylate synthase
M6D84_26290	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M6D84_26295	COG1494	fructose-1,6-bisphosphatase
M6D84_26315	COG4821	SIS domain
M6D84_26325	COG3343	RNA polymerase activity
M6D84_26335	COG1960	acyl-CoA dehydrogenase activity
M6D84_26340	COG1960	acyl-CoA dehydrogenase activity
M6D84_26345	COG1250	3-hydroxyacyl-CoA dehydrogenase
M6D84_26350	COG0183	Belongs to the thiolase family
M6D84_26355	COG2181	nitrate reductase activity
M6D84_26355	COG0247	lactate metabolic process
M6D84_26360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M6D84_26370	COG5001	Diguanylate cyclase
M6D84_26370	COG3300	MHYT domain
M6D84_26385	COG3227	Zinc metalloprotease (Elastase)
M6D84_26390	COG2197	response regulator
M6D84_26395	COG4585	Histidine kinase
M6D84_26400	COG0842	Transport permease protein
M6D84_26405	COG1131	(ABC) transporter
M6D84_26410	COG0024	Methionine aminopeptidase
M6D84_26420	COG2234	aminopeptidase activity
M6D84_26450	COG4506	Protein conserved in bacteria
M6D84_26455	COG1619	proteins homologs of microcin C7 resistance protein MccF
M6D84_26480	COG2814	Major facilitator Superfamily
M6D84_26485	COG0789	Transcriptional regulator
M6D84_26490	COG0584	glycerophosphoryl diester phosphodiesterase
M6D84_26495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M6D84_26505	COG1994	Peptidase M50
M6D84_26515	COG1078	dGTPase activity
M6D84_26520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M6D84_26525	COG1120	ATPase activity
M6D84_26530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M6D84_26535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M6D84_26555	COG0280	phosphate acetyltransferase
M6D84_26570	COG3773	Cell wall hydrolase
M6D84_26580	COG2363	Small membrane protein
M6D84_26590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M6D84_26595	COG2233	PERMEase
M6D84_26600	COG0561	phosphatase activity
M6D84_26605	COG2814	Major facilitator Superfamily
M6D84_26615	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M6D84_26620	COG1131	(ABC) transporter
M6D84_26625	COG2755	lipolytic protein G-D-S-L family
M6D84_26630	COG1609	Transcriptional regulator
M6D84_26640	COG0460	homoserine dehydrogenase
M6D84_26650	COG2873	o-acetylhomoserine
M6D84_26660	COG1011	Hydrolase
M6D84_26665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M6D84_26675	COG2197	response regulator
M6D84_26680	COG2203	Gaf domain
M6D84_26680	COG4585	Histidine kinase
M6D84_26685	COG0351	phosphomethylpyrimidine kinase
M6D84_26690	COG3706	GGDEF domain
M6D84_26695	COG2879	small protein
M6D84_26700	COG1966	Carbon starvation protein
M6D84_26705	COG3279	Response regulator of the LytR AlgR family
M6D84_26710	COG0477	Major facilitator Superfamily
M6D84_26715	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
M6D84_26720	COG0438	transferase activity, transferring glycosyl groups
M6D84_26735	COG0840	transmembrane signaling receptor activity
M6D84_26745	COG1607	acyl-coa hydrolase
M6D84_26750	COG1216	Glycosyl transferase, family 2
M6D84_26760	COG1216	Glycosyl transferase, family 2
M6D84_26770	COG4485	Bacterial membrane protein, YfhO
M6D84_26775	COG0463	Glycosyl transferase, family 2
M6D84_26780	COG0488	(ABC) transporter
M6D84_26785	COG1309	transcriptional regulator
M6D84_26790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M6D84_26795	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M6D84_26805	COG0628	permease
M6D84_26825	COG3275	phosphorelay sensor kinase activity
M6D84_26830	COG2814	Major facilitator Superfamily
M6D84_26835	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M6D84_26840	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
M6D84_26860	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M6D84_26865	COG1272	protein, Hemolysin III
M6D84_26885	COG1164	Oligoendopeptidase f
M6D84_26895	COG5002	protein histidine kinase activity
M6D84_26910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M6D84_26915	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M6D84_26920	COG4853	Protein conserved in bacteria
M6D84_26930	COG5002	protein histidine kinase activity
M6D84_26935	COG0745	RESPONSE REGULATOR receiver
M6D84_26965	COG0305	Participates in initiation and elongation during chromosome replication
M6D84_26975	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
M6D84_27000	COG0012	GTP binding
M6D84_27005	COG4481	Protein conserved in bacteria
M6D84_27010	COG0668	transmembrane transport
M6D84_27020	COG1475	DNA binding
M6D84_27025	COG1192	Involved in chromosome partitioning
M6D84_27050	COG1847	R3H domain protein
M6D84_27065	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M6D84_27275	COG2323	membrane
M6D84_27280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M6D84_27295	COG3655	Transcriptional regulator
M6D84_27370	COG2207	Transcriptional regulator
M6D84_27370	COG3708	Transcriptional regulator
M6D84_27420	COG0789	Transcriptional regulator
M6D84_27490	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M6D84_27505	COG4166	transmembrane transport
M6D84_27565	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
M6D84_27610	COG4974	Belongs to the 'phage' integrase family
M6D84_27630	COG2002	toxin-antitoxin pair type II binding
M6D84_27700	COG2311	Membrane
M6D84_27860	COG0798	PFAM Bile acid sodium symporter
M6D84_27865	COG0640	Transcriptional regulator
M6D84_27880	COG2824	Alkylphosphonate utilization operon protein PhnA
M6D84_27895	COG0659	secondary active sulfate transmembrane transporter activity
M6D84_27910	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M6D84_27915	COG0659	secondary active sulfate transmembrane transporter activity
M6D84_27920	COG0589	response to stress
M6D84_27925	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M6D84_27935	COG2072	flavoprotein involved in K transport
M6D84_27950	COG0640	Transcriptional regulator
M6D84_28265	COG3344	reverse transcriptase
M6D84_28285	COG0583	DNA-binding transcription factor activity
M6D84_28290	COG2814	Major facilitator Superfamily
M6D84_28350	COG0546	phosphoglycolate phosphatase activity
M6D84_28365	COG0167	dihydroorotate dehydrogenase activity
M6D84_28370	COG3238	Protein conserved in bacteria
M6D84_28375	COG1611	Belongs to the LOG family
M6D84_28380	COG1475	DNA binding
M6D84_28385	COG2368	4-hydroxyphenylacetate
M6D84_28390	COG0494	nUDIX hydrolase
M6D84_28405	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M6D84_28475	COG1073	alpha beta
M6D84_28485	COG1388	LysM domain
M6D84_28485	COG3103	Sh3 type 3 domain protein
M6D84_28485	COG0791	NLP P60 protein
M6D84_28525	COG3397	chitin binding
M6D84_28555	COG4974	Belongs to the 'phage' integrase family
M6D84_28560	COG1396	sequence-specific DNA binding
M6D84_28615	COG3344	reverse transcriptase
M6D84_28735	COG0457	Tetratricopeptide repeat
M6D84_28750	COG4974	Belongs to the 'phage' integrase family
M6D84_28760	COG0860	N-Acetylmuramoyl-L-alanine amidase
M6D84_28770	COG5002	protein histidine kinase activity
M6D84_28775	COG0745	RESPONSE REGULATOR receiver
M6D84_28780	COG2132	Multicopper oxidase
M6D84_28785	COG2304	oxidoreductase activity
M6D84_28790	COG1126	abc transporter atp-binding protein
M6D84_28795	COG0765	amino acid transport
M6D84_28800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M6D84_28810	COG3118	belongs to the thioredoxin family
M6D84_28850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M6D84_28870	COG3443	Belongs to the bacterial solute-binding protein 9 family
M6D84_28870	COG0803	Belongs to the bacterial solute-binding protein 9 family
M6D84_28875	COG1937	Protein conserved in bacteria
M6D84_28880	COG2217	Heavy metal translocating P-type atpase
M6D84_28920	COG1846	Transcriptional regulator
M6D84_28935	COG0640	Transcriptional regulator
M6D84_28940	COG0306	phosphate transporter
M6D84_28945	COG3620	sequence-specific DNA binding
M6D84_28955	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M6D84_28975	COG0640	Transcriptional regulator
M6D84_28980	COG0798	PFAM Bile acid sodium symporter
M6D84_29035	COG0745	RESPONSE REGULATOR receiver
M6D84_29040	COG4990	cell redox homeostasis
M6D84_29045	COG1335	isochorismatase
M6D84_29075	COG2918	glutathione biosynthetic process
M6D84_29075	COG1181	Belongs to the D-alanine--D-alanine ligase family
M6D84_29085	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
M6D84_29095	COG1733	regulation of RNA biosynthetic process
M6D84_29110	COG0697	spore germination