locus-tag class description bcf_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) bcf_00015 ENOG410848D S4 domain protein YaaA bcf_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) bcf_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) bcf_00070 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) bcf_00105 ENOG4105ZMH deoxynucleoside kinase bcf_00115 ENOG4105GTG Isochorismatase bcf_00120 ENOG4108Z6B deaminase bcf_00125 ENOG4105C6E dna polymerase iii bcf_00145 ENOG41067KS pro-sigma K processing bcf_00180 ENOG4105CXN decarboxylase bcf_00190 ENOG4105FA2 dna polymerase iii bcf_00195 ENOG4105MA4 psp1 domain protein bcf_00205 ENOG41060K3 Methyltransferase bcf_00215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) bcf_00220 ENOG4105KRN Transcriptional regulator, abrb family bcf_00230 ENOG4105F8V Hydrolase, tatD family bcf_00235 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) bcf_00245 ENOG4105XFA sporulation peptidase YabG bcf_00250 ENOG4105W42 Veg protein bcf_00265 ENOG4105DFT pur operon repressor bcf_00275 ENOG4105KME endoribonuclease L-psp bcf_00290 ENOG4105C5T Phosphoribosyl pyrophosphate synthase bcf_00295 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) bcf_00305 ENOG4108JA2 transcriptioN-repair coupling factor bcf_00310 ENOG4108M14 stage v sporulation protein t bcf_00320 ENOG4108IY2 MazG family bcf_00325 ENOG41082I2 s4 domain protein bcf_00330 ENOG4105VYY sporulation protein yabp bcf_00345 ENOG41060GV RNA binding s1 domain protein bcf_00370 ENOG4108UGV hypoxanthine phosphoribosyltransferase bcf_00375 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) bcf_00390 ENOG4105C6T cysteine synthase bcf_00395 ENOG4105CRQ synthase (Component I) bcf_00400 ENOG4105DDQ anthranilate synthase bcf_00405 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 bcf_00410 ENOG4105EEI dihydropteroate synthase bcf_00415 ENOG4105KRF dihydroneopterin aldolase bcf_00420 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase bcf_00430 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) bcf_00520 ENOG4108Z0C Uvrb UvrC protein bcf_00535 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) bcf_00545 ENOG4105CTP PilT protein domain protein bcf_00565 ENOG4105D7W serine acetyltransferase bcf_00580 ENOG4105C2N RNA methyltransferase TrmH family group 3 bcf_00585 ENOG4105M0M Tetracycline resistance protein bcf_00590 ENOG4105QIV RNA polymerase bcf_00605 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) bcf_00630 ENOG4107Y49 methyltransferase bcf_00650 ENOG4105XPM ribosomal protein bcf_00755 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) bcf_00780 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) bcf_00790 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) bcf_00800 ENOG41067V7 50S ribosomal protein L36 bcf_00830 ENOG4108JJB ABC transporter bcf_00835 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) bcf_00840 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) bcf_00865 ENOG4105D1F ATP-binding protein bcf_00880 ENOG4108NMV polysaccharide deacetylase bcf_00960 ENOG4105C8B TIGR00159 family bcf_00965 ENOG4107U5W ybbr family bcf_00995 ENOG4105CMG Carbohydrate kinase bcf_01005 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) bcf_01040 ENOG4108PSK reductase bcf_01045 ENOG4108UMI ABC transporter, permease bcf_01050 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) bcf_01055 ENOG4105D01 (LipO)protein bcf_01060 ENOG4105EE1 crotonyl-CoA reductase bcf_01070 ENOG4105IQ5 FAD linked oxidase domain protein bcf_01085 ENOG4105C2C drug resistance transporter, Bcr CflA bcf_01105 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component bcf_01110 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component bcf_01115 ENOG4105C3U ABC transporter bcf_01120 ENOG4108JQ7 (ABC) transporter bcf_01145 ENOG4105U5Y Transcriptional regulator bcf_01155 ENOG4108J59 Extracellular solute-binding protein, family 5 bcf_01160 ENOG4108J59 Extracellular solute-binding protein, family 5 bcf_01170 ENOG4105II7 pyrroline-5-carboxylate reductase bcf_01175 ENOG4107XDY Nicotinamide Mononucleotide Transporter bcf_01185 ENOG4105E0C molybdate abc transporter bcf_01190 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein bcf_01195 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family bcf_01215 ENOG4105F6E Acyl-transferase bcf_01235 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) bcf_01250 ENOG4108RE7 deoxyribonuclease bcf_01260 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) bcf_01285 ENOG4105C5H ABC transporter bcf_01305 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein bcf_01315 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component bcf_01320 ENOG4105C3U ABC transporter bcf_01325 ENOG4108JQ7 (ABC) transporter bcf_01330 ENOG410667J hydrolase bcf_01345 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase bcf_01350 ENOG4105ERH Fumarylacetoacetate hydrolase bcf_01360 ENOG4105CUB amino acid bcf_01365 ENOG4108SC4 )-transporter bcf_01370 ENOG4105CPF Cell wall formation (By similarity) bcf_01375 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) bcf_01390 ENOG4107ZXI Rhomboid family bcf_01400 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein bcf_01405 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) bcf_01415 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) bcf_01510 ENOG4105K8N protein family UPF0079, ATPase bcf_01515 ENOG41072GX Peptidase M22 Glycoprotease bcf_01520 ENOG410801F ribosomal-protein-alanine acetyltransferase bcf_01530 ENOG4105C5H ABC transporter bcf_01545 ENOG4108TYN CAAX amino terminal protease family protein bcf_01570 ENOG4107EV6 Inherit from COG: YD repeat protein bcf_01585 ENOG4105C7N Xanthine uracil vitamin C permease bcf_01595 ENOG4105BZU Histidine kinase bcf_01620 ENOG4107ZXU DSBA oxidoreductase bcf_01640 ENOG4105SX7 Transporter bcf_01670 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) bcf_01675 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit bcf_01680 ENOG4105C83 adenylosuccinate lyase bcf_01690 ENOG4105VR9 phosphoribosylformylglycinamidine synthase bcf_01715 ENOG4108V3E phosphoribosylglycinamide formyltransferase bcf_01725 ENOG4105C12 Phosphoribosylglycinamide synthetase bcf_01750 ENOG4105C4R Atp-dependent dna helicase bcf_01780 ENOG4108W2Y isochorismatase bcf_01785 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) bcf_01790 ENOG4108UMI ABC transporter, permease bcf_01795 ENOG4105D01 (LipO)protein bcf_01815 ENOG41067TZ transcriptional regulator, MarR family bcf_01820 ENOG4107I77 yiaA/B two helix domain bcf_01840 ENOG4105CBD Diacylglycerol kinase bcf_01845 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) bcf_01850 ENOG4108JPW Aminotransferase bcf_01860 ENOG4105C26 Dehydrogenase bcf_01865 ENOG4105KPY Small multidrug resistance protein bcf_01885 ENOG4105D9N nucleoside bcf_01890 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) bcf_01900 ENOG4105BZU Histidine kinase bcf_01905 ENOG4108W15 Protein of unknown function (DUF1456) bcf_01925 ENOG4105DTQ mandelate racemase muconate lactonizing bcf_01935 ENOG4105DFD Na H antiporter bcf_01955 ENOG4105D3R alkyl hydroperoxide reductase bcf_01960 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) bcf_01970 ENOG4107W7X Aldolase bcf_01980 ENOG4105EHG Permease protein bcf_01985 ENOG4105DQ5 transport system permease protein bcf_01990 ENOG4108V5C ABC transporter bcf_02010 ENOG4106UIA bcf_02015 ENOG4106UIA bcf_02035 ENOG4105BZU Histidine kinase bcf_02055 ENOG410756H nucleotidyltransferase bcf_02060 ENOG4105D2S major facilitator superfamily bcf_02075 ENOG4105E5Q amino acid AbC transporter bcf_02080 ENOG4105EAB amino acid AbC transporter bcf_02090 ENOG4105C8Q Methyl-accepting chemotaxis bcf_02095 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer bcf_02105 ENOG4105CI1 PTS System bcf_02135 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter bcf_02150 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component bcf_02165 ENOG4105C5H ABC transporter bcf_02200 ENOG41062JF Transcriptional regulator bcf_02220 ENOG4105DEU major facilitator superfamily bcf_02250 ENOG4108N0M stress protein bcf_02255 ENOG4106FN3 tellurium resistance protein bcf_02260 ENOG4106FN3 tellurium resistance protein bcf_02265 ENOG4107TS3 membrane protein, TerC bcf_02270 ENOG4108TTB tellurium resistance protein bcf_02285 ENOG41068PA UPF0435 protein bcf_02290 ENOG4105KJF protein tyrosine phosphatase bcf_02300 ENOG4107U9T Pfam:Ribonuclease_BN bcf_02305 ENOG4105C59 p-type ATPase bcf_02310 ENOG4108IPJ Membrane bcf_02330 ENOG4107ZTW SNARE associated Golgi bcf_02345 ENOG410606W general stress protein bcf_02350 ENOG4105UPD Calcium Proton bcf_02400 ENOG4108JUB Transcriptional regulator bcf_02415 ENOG4108IQI permease bcf_02445 ENOG4105CSV Glutaminase bcf_02455 ENOG4108A04 Beta-lactamase bcf_02470 ENOG4105CKK Glycosyl transferase, family 2 bcf_02475 ENOG4107QQG Dehydrogenase bcf_02480 ENOG4105C3I Nad-dependent epimerase dehydratase bcf_02495 ENOG4105F1A Pyruvate formate-lyase bcf_02515 ENOG4105CI2 imidazolone-5-propionate hydrolase bcf_02520 ENOG4105ECP epimerase bcf_02550 ENOG41067AE Membrane-bound metal-dependent hydrolase bcf_02555 ENOG4105CEN a g-specific adenine glycosylase bcf_02560 ENOG4106BXE bcf_02585 ENOG4105BZ1 (ABC) transporter bcf_02590 ENOG4107NBY Membrane bcf_02595 ENOG4105CBC glutamate synthase bcf_02605 ENOG4108IUW ABC transporter bcf_02625 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen bcf_02630 ENOG4105G5W regulator Fur family bcf_02765 ENOG4105BZ1 (ABC) transporter bcf_02780 ENOG4108JQC penicillin-binding protein 1A bcf_02785 ENOG4107ZQN disulfide bond bcf_02800 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) bcf_02810 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) bcf_02815 ENOG4105BZU Histidine kinase bcf_02825 ENOG4105CYN Serine protein kinase bcf_02855 ENOG4105C94 Transporter bcf_02870 ENOG4105DZ6 Band 7 protein bcf_02880 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism bcf_02885 ENOG4108V9W transcriptional regulatory protein bcf_02890 ENOG4105D4T Citrate transporter bcf_02915 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) bcf_02920 ENOG4108STX response regulator bcf_02925 ENOG4105US7 Histidine kinase bcf_02950 ENOG4108MRH transcriptional regulatory protein bcf_02960 ENOG4105C6K Malic enzyme bcf_02970 ENOG4108UZ3 Transporter bcf_02975 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family bcf_02985 ENOG4105BZU Histidine kinase bcf_02990 ENOG4105CK6 Two component transcriptional regulator (Winged helix family bcf_03005 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) bcf_03010 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) bcf_03015 ENOG4108JB9 formate dehydrogenase bcf_03035 ENOG4105CUB amino acid bcf_03045 ENOG4105C59 p-type ATPase bcf_03050 ENOG4105DAP Nicotinate phosphoribosyltransferase bcf_03090 ENOG41073R8 VanW family bcf_03095 ENOG4108KGH TRANSCRIPTIONal bcf_03100 ENOG4105D9N nucleoside bcf_03105 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase bcf_03110 ENOG4105C37 (CBS) domain bcf_03115 ENOG4108IJ0 Aspartate ammonia-lyase bcf_03120 ENOG4105DAA L-lactate bcf_03135 ENOG4105DUX Transporter bcf_03140 ENOG4105DUX Transporter bcf_03145 ENOG4108MES Periplasmic binding protein bcf_03150 ENOG4105DQ5 transport system permease protein bcf_03155 ENOG4108IHU transport system permease protein bcf_03160 ENOG4105E0A ABC, transporter bcf_03165 ENOG4105DMQ Methyltransferase bcf_03175 ENOG4105EXW epimerase dehydratase bcf_03185 ENOG4107T89 von Willebrand factor, type A bcf_03190 ENOG4105GMT ATPase associated with various cellular activities aaa_5 bcf_03195 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) bcf_03205 ENOG4105BZU Histidine kinase bcf_03210 ENOG4105D5Q Arginine ornithine antiporter bcf_03215 ENOG4107414 GntR family transcriptional regulator bcf_03220 ENOG4105C5Y PTS System bcf_03225 ENOG4105CG3 alpha amylase, catalytic region bcf_03240 ENOG4105E1K spore germination protein bcf_03245 ENOG4108XG2 Histidine kinase bcf_03250 ENOG4105WH1 Two component transcriptional regulator luxr family bcf_03255 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin bcf_03275 ENOG4105CRN Aminoglycoside phosphotransferase bcf_03280 ENOG4105BZG amino acid carrier protein bcf_03285 ENOG4105CDA abc transporter atp-binding protein bcf_03290 ENOG4105CT1 (ABC) transporter bcf_03295 ENOG4105EAD ABC transporter bcf_03300 ENOG4105DRP amino acid AbC transporter bcf_03305 ENOG4108IQI permease bcf_03330 ENOG4105D29 Helix-turn-helix type 11 domain protein bcf_03335 ENOG4105NAE bifunctional deaminase-reductase domain protein bcf_03340 ENOG4105BZU Histidine kinase bcf_03355 ENOG4105CHH sulfate transporter bcf_03360 ENOG41068KF Universal stress protein bcf_03370 ENOG4105DEF Extracellular solute-binding protein, family 5 bcf_03380 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component bcf_03385 ENOG4108JQ7 (ABC) transporter bcf_03395 ENOG4105CXY transporter bcf_03400 ENOG41067TZ transcriptional regulator, MarR family bcf_03405 ENOG4105C0R drug resistance transporter emrb qaca subfamily bcf_03410 ENOG4105ETE Transcriptional regulator (LacI family bcf_03415 ENOG4108RVA ribokinase bcf_03425 ENOG4105C2J ABC transporter bcf_03430 ENOG4105CNN ABC, transporter bcf_03435 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator bcf_03440 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) bcf_03500 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer bcf_03505 ENOG41069ER domain protein bcf_03510 ENOG4105VZ8 Transcriptional regulator bcf_03515 ENOG4107D63 bcf_03525 ENOG4105DUX Transporter bcf_03550 ENOG4105C85 amino acid bcf_03555 ENOG4105C7N Xanthine uracil vitamin C permease bcf_03570 ENOG4105MA6 gCN5-related N-acetyltransferase bcf_03595 ENOG4105BZ9 Cytochrome C oxidase, subunit I bcf_03600 ENOG4105E2S oxidase) subunit II bcf_03615 ENOG4106CAD Protein of unknown function (DUF3311) bcf_03620 ENOG4105E1V na solute symporter bcf_03635 ENOG4108NHD germination protein bcf_03645 ENOG4105CE1 Ferrous iron transport protein b bcf_03650 ENOG4105CE1 Ferrous iron transport protein b bcf_03655 ENOG4105CE1 Ferrous iron transport protein b bcf_03660 ENOG4105CVA phosphate bcf_03665 ENOG4105C8U phosphate abc transporter bcf_03670 ENOG4105E2Z phosphate ABC transporter (Permease bcf_03800 ENOG41080XQ Signal transduction protein with cbs domains bcf_03825 ENOG4105ETU transcriptional activator (TenA bcf_03835 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component bcf_03845 ENOG4108VEU Thiamine monophosphate synthase bcf_03850 ENOG41080HI glycine oxidase bcf_03865 ENOG4105D06 uba thif-type nad fad binding protein bcf_03870 ENOG4105DWF phosphomethylpyrimidine kinase bcf_03915 ENOG4108INS Transcriptional regulator bcf_03940 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) bcf_03950 ENOG4105C7N Xanthine uracil vitamin C permease bcf_03960 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein bcf_03980 ENOG4105C5Y PTS System bcf_04015 ENOG4108B31 Spore germination protein bcf_04035 ENOG4107Y03 Nitroreductase bcf_04040 ENOG4105ED1 spovr family bcf_04045 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 bcf_04055 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase bcf_04060 ENOG4105XTG Pfam:DUF156 bcf_04065 ENOG4105VFE sira family bcf_04070 ENOG4107TPS domain protein bcf_04075 ENOG4105VFE sira family bcf_04080 ENOG41085GJ domain protein bcf_04090 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase bcf_04095 ENOG41087NI Sulfite exporter TauE/SafE bcf_04105 ENOG4108KGH TRANSCRIPTIONal bcf_04130 ENOG4105EMD TRANSCRIPTIONal bcf_04135 ENOG4105VCP PTS System bcf_04140 ENOG4105VZJ PTS System bcf_04160 ENOG41069ER domain protein bcf_04165 ENOG4107RBB ABC transporter, permease bcf_04170 ENOG4105C19 ABC transporter bcf_04205 ENOG4105WEF catalase bcf_04240 ENOG4107T5V SNARE associated Golgi bcf_04275 ENOG4105CUB amino acid bcf_04280 ENOG4107RWR Sodium hydrogen exchanger bcf_04290 ENOG4106KNT transcriptional regulator bcf_04335 ENOG4108YXU transcriptional regulator AsnC family bcf_04345 ENOG4105KPY Small multidrug resistance protein bcf_04350 ENOG4105KPY Small multidrug resistance protein bcf_04365 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) bcf_04370 ENOG4105E5W Transporter bcf_04380 ENOG4107RKG DJ-1/PfpI family bcf_04385 ENOG4105CH6 catalase bcf_04395 ENOG4105D5Q Arginine ornithine antiporter bcf_04400 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) bcf_04410 ENOG4105C26 Dehydrogenase bcf_04415 ENOG4105BZ1 (ABC) transporter bcf_04420 ENOG4105BZ1 (ABC) transporter bcf_04430 ENOG4105DRP amino acid AbC transporter bcf_04435 ENOG4105CDA abc transporter atp-binding protein bcf_04450 ENOG410839P bcf_04485 ENOG4107FQX Alpha-acetolactate decarboxylase bcf_04500 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase bcf_04505 ENOG4105D4P Coproporphyrinogen iii oxidase bcf_04520 ENOG4105CHH sulfate transporter bcf_04560 ENOG4106AKK s-layer domain-containing protein bcf_04565 ENOG4106AKK s-layer domain-containing protein bcf_04575 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein bcf_04585 ENOG4105CGU Enoyl-CoA hydratase bcf_04605 ENOG4105DER m42 family bcf_04625 ENOG4105CTU Proline racemase bcf_04630 ENOG4105CTU Proline racemase bcf_04650 ENOG4105CSH Transporter bcf_04660 ENOG4108MRH transcriptional regulatory protein bcf_04700 ENOG4107SCJ type I restriction enzyme EcoKI subunit R bcf_04745 ENOG4105CDU Replicative dna helicase bcf_04770 ENOG4105C0R drug resistance transporter emrb qaca subfamily bcf_04820 ENOG4107P5I polyketide synthase bcf_04825 ENOG4108IG5 Transcriptional regulator bcf_04840 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase bcf_04870 ENOG4105CMT Dihydroxyacetone kinase bcf_04880 ENOG4105CMT Dihydroxyacetone kinase bcf_04885 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) bcf_04890 ENOG410847I Transcriptional regulator, BadM Rrf2 family bcf_04905 ENOG410780I phosphoprotein phosphatase activity bcf_04915 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase bcf_04985 ENOG4105WN5 stage II sporulation protein bcf_04995 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) bcf_05005 ENOG4108MJI response regulator bcf_05010 ENOG4105BZU Histidine kinase bcf_05015 ENOG4105BZU Histidine kinase bcf_05040 ENOG4105K8R UPF0145 protein bcf_05060 ENOG4105ENE Histidine kinase bcf_05065 ENOG4108VB1 regulatoR bcf_05100 ENOG4107VRP DNA repair exonuclease bcf_05105 ENOG4106D4I domain protein bcf_05155 ENOG4108MUZ hydrolase bcf_05175 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator bcf_05190 ENOG4105C6V Glycerol-3-phosphate dehydrogenase bcf_05210 ENOG4105EMN RNA polymerase sigma factor bcf_05235 ENOG4105C57 major facilitator superfamily bcf_05240 ENOG4105C0R drug resistance transporter emrb qaca subfamily bcf_05250 ENOG4105EEM helicase bcf_05255 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) bcf_05280 ENOG4105K59 histidine triad (HIT) protein bcf_05350 ENOG410905X membrane-flanked domain protein bcf_05355 ENOG4105CKV Membrane bcf_05370 ENOG4108TVJ Nitroreductase bcf_05390 ENOG410905X membrane-flanked domain protein bcf_05395 ENOG4105CKV Membrane bcf_05400 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation bcf_05405 ENOG4105BZ4 penicillin-binding protein bcf_05420 ENOG4105C1Q protoporphyrinogen oxidase bcf_05450 ENOG4105NA0 Transcriptional regulator bcf_05465 ENOG4105ECB domain protein bcf_05490 ENOG4106AXD bcf_05495 ENOG4108RQ5 Beta-lactamase domain-containing protein bcf_05500 ENOG4105DF9 Lipoate-protein, ligase bcf_05510 ENOG4105CEY Amp-dependent synthetase and ligase bcf_05575 ENOG4105ST3 Transcriptional regulator bcf_05580 ENOG4105ENX hydrolase bcf_05585 ENOG4107RN3 metallophosphoesterase bcf_05595 ENOG4107TVP HD domain protein bcf_05605 ENOG4108AEY RNA polymerase sigma factor bcf_05610 ENOG41086D8 Transcriptional regulator bcf_05620 ENOG4105DPZ Two component transcriptional regulator (Winged helix family bcf_05640 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 bcf_05665 ENOG4105ZU5 s-layer protein bcf_05670 ENOG4107QP3 malate synthase g bcf_05685 ENOG4105VEQ Cold shock protein bcf_05700 ENOG4105XVF Competence transcription factor bcf_05765 ENOG4105ERH Fumarylacetoacetate hydrolase bcf_05790 ENOG4105CAQ asparagine synthetase bcf_05795 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) bcf_05800 ENOG4105CH6 catalase bcf_05805 ENOG4105BZU Histidine kinase bcf_05810 ENOG4105BZU Histidine kinase bcf_05830 ENOG4105QNR S1 RNA binding domain protein bcf_05840 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) bcf_05850 ENOG4107AYK membrAne bcf_05855 ENOG41073B9 bcf_05865 ENOG4108KP7 hydrolase bcf_05875 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit bcf_05900 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) bcf_05905 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) bcf_05910 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) bcf_05925 ENOG4105C31 Tryptophanyl-tRNA synthetase bcf_05940 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component bcf_05945 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component bcf_05955 ENOG4108JQ7 (ABC) transporter bcf_05960 ENOG4105UQX Mate efflux family protein bcf_05985 ENOG4108ZCF integral membrane protein bcf_05995 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) bcf_06005 ENOG4105DPN Oligoendopeptidase f bcf_06020 ENOG4108Z18 K06886 hemoglobin bcf_06025 ENOG4105MIX Adenylate cyclase bcf_06040 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) bcf_06045 ENOG4105EMS pseudouridine synthase bcf_06065 ENOG4105K64 Glycosyl transferase, family 2 bcf_06085 ENOG4107TVC Glycosyl transferase, family 2 bcf_06105 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) bcf_06110 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase bcf_06120 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase bcf_06195 ENOG4105CK7 Sodium proline symporter bcf_06205 ENOG4105CRQ synthase (Component I) bcf_06210 ENOG4105DDQ anthranilate synthase bcf_06300 ENOG4105C7S Dehydrogenase bcf_06310 ENOG4105VZ8 Transcriptional regulator bcf_06425 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) bcf_06440 ENOG4108IUX (ABC) transporter bcf_06445 ENOG4105RHA ABC transporter, permease bcf_06460 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) bcf_06470 ENOG4105DZ1 carboxypeptidase bcf_06475 ENOG4105VFR signal peptidase bcf_06510 ENOG4105C26 Dehydrogenase bcf_06520 ENOG4105F38 ABC transporter, permease bcf_06525 ENOG4105D38 putrescine abc transporter bcf_06530 ENOG4107RUE extracellular solute-binding protein family 1 bcf_06540 ENOG4105EYF MMPL domain protein bcf_06550 ENOG4108YBP pseudouridine synthase bcf_06560 ENOG4105K4I Scp-like extracellular bcf_06565 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) bcf_06570 ENOG4105CQB FAD linked oxidase domain protein bcf_06585 ENOG4105CK6 Two component transcriptional regulator (Winged helix family bcf_06590 ENOG4105BZU Histidine kinase bcf_06595 ENOG4105JXH GntR family transcriptional regulator bcf_06615 ENOG4106A3R peptidase bcf_06625 ENOG4108QTI )-transporter bcf_06630 ENOG4107TS3 membrane protein, TerC bcf_06635 ENOG4105CZN Potassium uptake protein bcf_06640 ENOG410681C small acid-soluble spore protein bcf_06645 ENOG4108Z7G MaoC domain protein dehydratase bcf_06665 ENOG4105CHR reductase bcf_06675 ENOG4105MWK D-amino acid dehydrogenase, small subunit bcf_06695 ENOG4105C4Y ABC transporter bcf_06700 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) bcf_06705 ENOG4107RCV ABC transporter, permease bcf_06710 ENOG4108KAZ Involved in phosphonate degradation (By similarity) bcf_06725 ENOG4105E98 transcriptional regulator DeoR family bcf_06740 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) bcf_06750 ENOG4105PXI polysaccharide deacetylase bcf_06760 ENOG4105BZU Histidine kinase bcf_06765 ENOG41090MY MarR family Transcriptional regulator bcf_06775 ENOG4106DF1 bcf_06785 ENOG4105BZU Histidine kinase bcf_06795 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase bcf_06800 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) bcf_06840 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) bcf_06845 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) bcf_06850 ENOG41079K6 HNH endonuclease bcf_06855 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) bcf_06860 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) bcf_06865 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family bcf_06870 ENOG4105CZV ABC transporter bcf_06880 ENOG4105CJ1 ABC, transporter bcf_06920 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A bcf_06925 ENOG4105EA8 2-Nitropropane dioxygenase bcf_06930 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD bcf_06940 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein bcf_06965 ENOG4105NQC Flavodoxin bcf_07000 ENOG4107QMU Mate efflux family protein bcf_07005 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) bcf_07035 ENOG4105CZN Potassium uptake protein bcf_07040 ENOG41063Y9 bcf_07045 ENOG4105KBJ sporulation protein ytfj bcf_07070 ENOG4105CM2 brancheD-chain amino acid aminotransferase bcf_07075 ENOG4105C7K acetolactate synthase bcf_07080 ENOG4108ZP8 Acetolactate synthase small subunit bcf_07155 ENOG4107RVV histidinol phosphate phosphatase, hisj family bcf_07170 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase bcf_07175 ENOG4105E0M Sulfatase bcf_07185 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) bcf_07205 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) bcf_07210 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) bcf_07220 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) bcf_07225 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein bcf_07230 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein bcf_07235 ENOG4105C8J )-transporter bcf_07260 ENOG4105DFD Na H antiporter bcf_07280 ENOG4105ENE Histidine kinase bcf_07285 ENOG4105WH1 Two component transcriptional regulator luxr family bcf_07290 ENOG4105WH1 Two component transcriptional regulator luxr family bcf_07310 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) bcf_07355 ENOG4105CJ3 phosphate transporter bcf_07360 ENOG4107GRR phosphate transport regulator bcf_07365 ENOG4105BZ4 penicillin-binding protein bcf_07380 ENOG4105BZU Histidine kinase bcf_07385 ENOG4105I3N Conserved Protein bcf_07400 ENOG4105BZU Histidine kinase bcf_07430 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) bcf_07435 ENOG4105DZ1 carboxypeptidase bcf_07440 ENOG4108JIC nucleoside recognition domain protein bcf_07450 ENOG4105FE9 pseudouridine synthase bcf_07460 ENOG4107TWT Cytochrome c biogenesis protein bcf_07465 ENOG4105CRE cytochrome C bcf_07470 ENOG4105CK6 Two component transcriptional regulator (Winged helix family bcf_07475 ENOG4105BZU Histidine kinase bcf_07480 ENOG4108WBT adenosyltransferase bcf_07485 ENOG41063SB peptidase bcf_07500 ENOG4108SAX Membrane bcf_07515 ENOG4105C9U ATP-dependent DNA helicase RecQ bcf_07520 ENOG4105I7S Abortive infection protein bcf_07530 ENOG4107RGJ metallophosphoesterase bcf_07535 ENOG4107X2D transcriptional regulator, merr family bcf_07540 ENOG4108S6Z Negative regulator of genetic competence bcf_07545 ENOG4108S6Z Negative regulator of genetic competence bcf_07570 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase bcf_07575 ENOG4107RB3 L-asparaginase bcf_07605 ENOG4105S2F bcf_07610 ENOG41065D1 bcf_07640 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) bcf_07655 ENOG4105XXQ heptaprenyl diphosphate synthase component I bcf_07665 ENOG4105EAH synthase bcf_07685 ENOG4105CIH Imidazole acetol-phosphate transaminase bcf_07690 ENOG41068YB TPR repeat-containing protein bcf_07705 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) bcf_07710 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) bcf_07715 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit bcf_07745 ENOG4108JYZ YitT family bcf_07750 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase bcf_07765 ENOG4105FJR Lmbe family bcf_07770 ENOG4105CPK Glycosyl transferase (Group 1 bcf_07805 ENOG4105DVT helicase bcf_07810 ENOG4105YAC bcf_07830 ENOG4105CSM endonuclease III bcf_07840 ENOG4105BZ4 penicillin-binding protein bcf_07900 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) bcf_07910 ENOG4105DVT helicase bcf_07915 ENOG4105CTD carboxy-peptidase bcf_07930 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) bcf_07940 ENOG4105C2W permease bcf_07945 ENOG4105DHF Membrane bcf_07955 ENOG410890F Dynamin family bcf_07965 ENOG4108W0I acetyltransferase bcf_07975 ENOG4105KHC sulfurtransferase bcf_07990 ENOG4106032 Glutathionylspermidine synthase bcf_08020 ENOG4108SZE gCN5-related N-acetyltransferase bcf_08040 ENOG41081VK Ribonuclease bcf_08105 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) bcf_08115 ENOG4107RWR Sodium hydrogen exchanger bcf_08120 ENOG4105CN5 Metallo-Beta-Lactamase bcf_08125 ENOG4108Z5V transcriptional regulator, merr family bcf_08135 ENOG4105H67 Protein of unknown function (DUF421) bcf_08145 ENOG41080C8 DUF218 domain bcf_08200 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) bcf_08210 ENOG4107R0U MotA TolQ exbB proton channel bcf_08215 ENOG4105ER2 Ompa motb domain protein bcf_08220 ENOG4107YTP response regulator receiver protein bcf_08225 ENOG4105CBS Chea signal transduction histidine kinase bcf_08230 ENOG4105DD5 Flagellar motor switch protein bcf_08245 ENOG4105BZU Histidine kinase bcf_08265 ENOG4105E1Q flagellar hook-associated protein bcf_08270 ENOG4105DTJ flagellar hook-associated protein bcf_08275 ENOG410804A Flagellar hook-associated 2 domain-containing protein bcf_08290 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) bcf_08295 ENOG4108ZC9 flagellar basal-body rod protein flgc bcf_08300 ENOG41075Z6 flagellar hook-basal body complex protein fliE bcf_08305 ENOG4107U2N Flagellar M-ring protein bcf_08310 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) bcf_08340 ENOG4105BZE flagellar hook protein, FlgE bcf_08355 ENOG4107R88 Chemotaxis protein (CheV) bcf_08380 ENOG4105I03 Flagellin bcf_08385 ENOG4105E4C Lytic transglycosylase catalytic bcf_08395 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) bcf_08400 ENOG4105DD5 Flagellar motor switch protein bcf_08410 ENOG4105CN7 Flagellar biosynthetic protein FliP bcf_08415 ENOG4105VS8 Flagellar biosynthetic protein fliq bcf_08425 ENOG4105D00 flagellar biosynthetic protein flhB bcf_08430 ENOG4105D7B Flagellar biosynthesis protein flha bcf_08435 ENOG4105FZW flagellar biosynthesis regulator FlhF bcf_08440 ENOG4105KTQ flagellar basal-body rod protein bcf_08445 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) bcf_08470 ENOG41062JF Transcriptional regulator bcf_08505 ENOG4105KAC Antibiotic biosynthesis monooxygenase bcf_08530 ENOG4105DUM transcriptional regulator, lysR family bcf_08535 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) bcf_08540 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein bcf_08545 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component bcf_08550 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) bcf_08565 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr bcf_08590 ENOG4105CVJ phosphoglycerate mutase bcf_08610 ENOG4105K56 Transcriptional regulator bcf_08620 ENOG4105CAQ asparagine synthetase bcf_08640 ENOG4105PGM cation diffusion facilitator family transporter bcf_08650 ENOG4105DRR Transcriptional regulator, GntR family bcf_08655 ENOG4108UZ3 Transporter bcf_08660 ENOG4105CKI cobalamin synthesis protein bcf_08670 ENOG4108PJD permease bcf_08685 ENOG4105DFD Na H antiporter bcf_08690 ENOG4105C9Q fumarate hydratase class II bcf_08715 ENOG4107QJQ Mate efflux family protein bcf_08720 ENOG4105EC3 peptidase S51, dipeptidase E bcf_08740 ENOG4107QIV Cytochrome c biogenesis protein bcf_08770 ENOG4106BRA Membrane bcf_08805 ENOG4105CJ1 ABC, transporter bcf_08825 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) bcf_08835 ENOG4108IJ0 Aspartate ammonia-lyase bcf_08840 ENOG4105C6K Malic enzyme bcf_08875 ENOG41067QW Transcriptional regulator bcf_08895 ENOG4105FVX bcf_08940 ENOG4105CSR polyphosphate kinase 2 bcf_08945 ENOG4105DXI Major Facilitator superfamily bcf_08960 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) bcf_08970 ENOG4105EU0 Major facilitator Superfamily bcf_08975 ENOG4105C6T cysteine synthase bcf_08995 ENOG4105C8J )-transporter bcf_09005 ENOG4105X5K response regulator receiver protein bcf_09010 ENOG4105H67 Protein of unknown function (DUF421) bcf_09025 ENOG4106KE4 Dehydrogenase bcf_09045 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) bcf_09050 ENOG4105CHR reductase bcf_09055 ENOG4105CM2 brancheD-chain amino acid aminotransferase bcf_09060 ENOG4105C7K acetolactate synthase bcf_09070 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase bcf_09080 ENOG4105C7B Threonine dehydratase bcf_09100 ENOG4105C6X Major Facilitator bcf_09105 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b bcf_09125 ENOG4105DY9 regulatoR bcf_09130 ENOG4105CYC Transferase bcf_09155 ENOG4108IBT Inherit from COG: transposase bcf_09200 ENOG41068WN bcf_09205 ENOG4105DPZ Two component transcriptional regulator (Winged helix family bcf_09225 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) bcf_09240 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) bcf_09255 ENOG4105C0X amino acid bcf_09305 ENOG4105DPZ Two component transcriptional regulator (Winged helix family bcf_09315 ENOG4107RHR regulatoR bcf_09325 ENOG4105D9N nucleoside bcf_09330 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) bcf_09335 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) bcf_09365 ENOG4107RAQ aminopeptidase bcf_09370 ENOG4107R16 Multicopper oxidase bcf_09415 ENOG4108T5E Copper resistance protein bcf_09420 ENOG4108T5E Copper resistance protein bcf_09425 ENOG4105KTB nuclear export factor GLE1 bcf_09430 ENOG4107RT3 EamA-like transporter family bcf_09435 ENOG4105GZI Transcriptional regulator bcf_09440 ENOG4108Z40 Transcriptional regulator bcf_09445 ENOG4107ZXU DSBA oxidoreductase bcf_09450 ENOG4108TVJ Nitroreductase bcf_09460 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) bcf_09465 ENOG4106F5Q Membrane bcf_09470 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) bcf_09485 ENOG4105CKI cobalamin synthesis protein bcf_09505 ENOG4108Z7G MaoC domain protein dehydratase bcf_09510 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) bcf_09520 ENOG4105C0Z ABC transporter bcf_09525 ENOG4108IV0 ABC, transporter bcf_09530 ENOG4105C32 Amino acid ABC transporter (Permease) bcf_09540 ENOG4105EGI Transcriptional regulator bcf_09550 ENOG4105MDS 4-oxalocrotonate tautomerase bcf_09570 ENOG4105C4M (Ubiquinol oxidase) subunit I bcf_09575 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii bcf_09580 ENOG4108JJ9 ABC, transporter bcf_09585 ENOG4108JJ8 (ABC) transporter bcf_09600 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A bcf_09630 ENOG4105BZ1 (ABC) transporter bcf_09635 ENOG4105EFI regulatoR bcf_09640 ENOG4105EB3 Histidine kinase bcf_09655 ENOG4108VQJ O-methyltransferase bcf_09660 ENOG41075D4 Aminoglycoside 6-adenylyltransferase bcf_09665 ENOG4108ZJ4 polysaccharide deacetylase bcf_09685 ENOG4105D6E homoserine dehydrogenase bcf_09710 ENOG4108KGH TRANSCRIPTIONal bcf_09720 ENOG4105DPZ Two component transcriptional regulator (Winged helix family bcf_09725 ENOG4105BZU Histidine kinase bcf_09730 ENOG4107VMI polysaccharide deacetylase bcf_09740 ENOG4105KT7 mgtC SapB transporter bcf_09745 ENOG4105VRR gCN5-related N-acetyltransferase bcf_09755 ENOG4105DUU IucA IucC family protein bcf_09760 ENOG4105CEY Amp-dependent synthetase and ligase bcf_09775 ENOG4108WBH protein TIM barrel bcf_09780 ENOG4105YWU small acid-soluble spore protein bcf_09790 ENOG4108ZUB Lysine exporter protein (Lyse ygga) bcf_09795 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family bcf_09845 ENOG4105KRN Transcriptional regulator, abrb family bcf_09855 ENOG4105YVS arsR family transcriptional regulator bcf_09860 ENOG4107SET aldo keto reductase bcf_09865 ENOG4107XZQ multidrug resistance protein bcf_09890 ENOG4105C8Q Methyl-accepting chemotaxis bcf_09905 ENOG4108K88 Membrane bcf_09910 ENOG4108WPJ Ferritin-like domain bcf_09925 ENOG4105DEN Luciferase family bcf_09940 ENOG4105VMI -acetyltransferase bcf_09945 ENOG4107QM2 Aldo Keto reductase bcf_09950 ENOG4105CKI cobalamin synthesis protein bcf_09970 ENOG4108IBT Inherit from COG: transposase bcf_09975 ENOG4105DSE periplasmic solute binding protein bcf_09985 ENOG4105K4T epimerase bcf_09995 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) bcf_10020 ENOG4105CVJ phosphoglycerate mutase bcf_10040 ENOG4107T5V SNARE associated Golgi bcf_10055 ENOG4108PJD permease bcf_10065 ENOG4108S4H thioesterase Superfamily protein bcf_10070 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) bcf_10090 ENOG4105SXS Protein of unknown function (DUF456) bcf_10095 ENOG4105C37 (CBS) domain bcf_10115 ENOG4108Z7R Chaperone CsaA bcf_10130 ENOG4108ZRV stage ii sporulation protein p bcf_10140 ENOG4108VXD carboxy-peptidase bcf_10170 ENOG4105EFA 4-hydroxyphenylacetate bcf_10180 ENOG4105U1N riboflavin bcf_10195 ENOG4105KME endoribonuclease L-psp bcf_10225 ENOG41069HH 4-oxalocrotonate tautomerase bcf_10235 ENOG4108X4Q Hydrolase bcf_10245 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) bcf_10250 ENOG4107RBS Methyltransferase bcf_10265 ENOG41087PP glycosyltransferase MGT family bcf_10270 ENOG4108JYZ YitT family bcf_10275 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family bcf_10305 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) bcf_10385 ENOG4105KBJ sporulation protein ytfj bcf_10410 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) bcf_10430 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) bcf_10435 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily bcf_10445 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein bcf_10450 ENOG4105EMN RNA polymerase sigma factor bcf_10465 ENOG4105CNW domain protein bcf_10475 ENOG4108V06 Glutathione peroxidase bcf_10490 ENOG4105C7R Atpase associated with various cellular activities aaa_3 bcf_10510 ENOG4108IUE nitrate reductase beta subunit bcf_10515 ENOG4105R3A Nitrate reductase bcf_10525 ENOG4107V6Q Cyclic nucleotide-binding domain bcf_10530 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) bcf_10535 ENOG4105D06 uba thif-type nad fad binding protein bcf_10540 ENOG4105CVM Molybdenum cofactor synthesis domain protein bcf_10545 ENOG4108ZAF Molybdopterin bcf_10570 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein bcf_10575 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein bcf_10580 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) bcf_10585 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit bcf_10590 ENOG4108IFG nitrite reductase, (NAD(P)H) bcf_10595 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) bcf_10620 ENOG4105MCT stage V sporulation protein S bcf_10660 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase bcf_10690 ENOG4105C5H ABC transporter bcf_10750 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes bcf_10770 ENOG4105CJ3 phosphate transporter bcf_10790 ENOG41067QW Transcriptional regulator bcf_10800 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) bcf_10825 ENOG41082YX Transcriptional regulator, arsr family bcf_10830 ENOG4105D6J arsenicaL-resistance protein bcf_10875 ENOG4108UUM single-stranded DNA-binding protein bcf_10905 ENOG4107YX5 Pfam:DUF548 bcf_10945 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) bcf_10950 ENOG4105C5S asparaginyl-tRNA synthetase bcf_10970 ENOG4105EC2 ftsk spoIIIe bcf_11085 ENOG4105BZW Glycerate kinase bcf_11090 ENOG4107QPK )-transporter bcf_11095 ENOG4105CK6 Two component transcriptional regulator (Winged helix family bcf_11100 ENOG41062D9 Histidine kinase bcf_11115 ENOG4105C8J )-transporter bcf_11135 ENOG4107XGZ Hydrolase bcf_11140 ENOG4105CY2 Citrate transporter bcf_11145 ENOG4105C0A alcohol dehydrogenase bcf_11160 ENOG4105KD7 acetyltransferase bcf_11165 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase bcf_11190 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 bcf_11210 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) bcf_11230 ENOG4107RVG penicillin-binding protein bcf_11240 ENOG4105E9Q Acyl-transferase bcf_11245 ENOG4108UT2 hemolysin iii bcf_11255 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) bcf_11265 ENOG4108RCR degv family bcf_11270 ENOG4105E8R UPF0173 metal-dependent hydrolase bcf_11275 ENOG4108KF3 Electron transport protein SCO1 SenC bcf_11280 ENOG4107Y70 Heat shock protein bcf_11285 ENOG4105CAQ asparagine synthetase bcf_11305 ENOG4108MES Periplasmic binding protein bcf_11310 ENOG4105F0I Aminotransferase bcf_11345 ENOG4105D8X mechanosensitive ion channel bcf_11350 ENOG4105BZU Histidine kinase bcf_11355 ENOG4105WH1 Two component transcriptional regulator luxr family bcf_11360 ENOG4106KNT transcriptional regulator bcf_11390 ENOG4105CMG Carbohydrate kinase bcf_11420 ENOG4108IJ8 ABC transporter bcf_11425 ENOG4105E90 ABC transporter bcf_11460 ENOG4105C37 (CBS) domain bcf_11490 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) bcf_11505 ENOG4107S4Y M20 DapE family protein YgeY bcf_11510 ENOG4108TSC N-acetyltransferase bcf_11515 ENOG4108JUB Transcriptional regulator bcf_11520 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein bcf_11560 ENOG4108N23 SpoOM-related protein bcf_11565 ENOG410841Q phosphoesterase PA-phosphatase related protein bcf_11575 ENOG4105SZ6 Thioredoxin bcf_11630 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) bcf_11680 ENOG4105BZ4 penicillin-binding protein bcf_11685 ENOG4105CZM Major Facilitator bcf_11690 ENOG4105W8X HesB YadR YfhF-family protein bcf_11700 ENOG4105DXD 2-methylcitrate dehydratase bcf_11705 ENOG4105CR4 methylisocitrate lyase bcf_11715 ENOG4105C1G acyl-Coa dehydrogenase bcf_11720 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase bcf_11730 ENOG4105N14 lysine exporter protein LysE YggA bcf_11735 ENOG4105E39 Enoyl-CoA hydratase bcf_11750 ENOG4107RFY SbcCD D subunit bcf_11775 ENOG4105FCD Major Facilitator bcf_11780 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase bcf_11785 ENOG4105E4F Isochorismate synthase bcf_11790 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase bcf_11795 ENOG4105WQI isochorismatase bcf_11800 ENOG4105CEY Amp-dependent synthetase and ligase bcf_11805 ENOG4105WQT MbtH domain protein bcf_11810 ENOG4105C0R drug resistance transporter emrb qaca subfamily bcf_11825 ENOG4105K70 DNA-binding protein bcf_11845 ENOG4105BZG amino acid carrier protein bcf_11865 ENOG4105FE9 pseudouridine synthase bcf_11875 ENOG4105C22 threonyL-tRNA synthetase bcf_11885 ENOG4105C19 ABC transporter bcf_11895 ENOG4107SKW Inherit from COG: Alpha beta hydrolase bcf_11920 ENOG4108D32 Methyltransferase bcf_11955 ENOG41081I9 integral membrane protein bcf_11970 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) bcf_11980 ENOG4105EYF MMPL domain protein bcf_12005 ENOG4105WCN acetyltransferase bcf_12035 ENOG4105C1Q protoporphyrinogen oxidase bcf_12045 ENOG41089UC methyltransferase, type 11 bcf_12050 ENOG41068WN bcf_12060 ENOG4105VEQ Cold shock protein bcf_12085 ENOG4107V2S Transcriptional regulator bcf_12090 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) bcf_12105 ENOG4105DND Transcriptional regulator bcf_12110 ENOG4108RPX mosc domain containing protein bcf_12125 ENOG4105BZ1 (ABC) transporter bcf_12130 ENOG4105BZ1 (ABC) transporter bcf_12145 ENOG4108JCI Transcriptional regulator bcf_12185 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) bcf_12200 ENOG4108KPJ rna polymerase sigma factor bcf_12230 ENOG4105F32 YngK protein bcf_12255 ENOG4105RD7 BadF BadG BcrA BcrD bcf_12265 ENOG4107STF Involved in phosphonate degradation (By similarity) bcf_12300 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) bcf_12315 ENOG4105C1J atp-dependent rna helicase bcf_12335 ENOG4108RZE Tetr family transcriptional regulator bcf_12350 ENOG41088CC tellurite resistance protein tehB bcf_12365 ENOG4107RA9 decarboxylase bcf_12370 ENOG4105VTR Integrase bcf_12450 ENOG4107RA9 decarboxylase bcf_12460 ENOG41090HR transcriptional regulator bcf_12500 ENOG4105CIN aminoacyl-histidine dipeptidase bcf_12515 ENOG4105EQK -acetyltransferase bcf_12530 ENOG4107RVG penicillin-binding protein bcf_12545 ENOG4107RF6 penicillin-binding protein bcf_12550 ENOG4107RF6 penicillin-binding protein bcf_12565 ENOG4105ETE Transcriptional regulator (LacI family bcf_12570 ENOG4105IE8 Alpha-ketoglutarate permease bcf_12575 ENOG4105CK5 oxidoreductase bcf_12600 ENOG4105D2N Aldolase bcf_12605 ENOG4105DH8 myo-inositol catabolism bcf_12630 ENOG4105CGH 5'-nucleotidase bcf_12640 ENOG4107JM4 Tetratricopeptide repeat bcf_12645 ENOG4105VZ8 Transcriptional regulator bcf_12655 ENOG4108VXD carboxy-peptidase bcf_12675 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity bcf_12680 ENOG41067SE Tetr family transcriptional regulator bcf_12685 ENOG4105C5H ABC transporter bcf_12695 ENOG4105BZU Histidine kinase bcf_12725 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) bcf_12750 ENOG4105C1G acyl-Coa dehydrogenase bcf_12755 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase bcf_12760 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit bcf_12765 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase bcf_12770 ENOG4105E39 Enoyl-CoA hydratase bcf_12775 ENOG4107QX3 carboxylase bcf_12780 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) bcf_12795 ENOG4105DBI uridine monophosphokinase bcf_12830 ENOG4105T9C HD domain bcf_12840 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) bcf_12880 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) bcf_12880 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) bcf_12905 ENOG4107Y80 Major Facilitator superfamily bcf_12915 ENOG41089UC methyltransferase, type 11 bcf_12995 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein bcf_13000 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein bcf_13010 ENOG4105DK7 lysyl-tRNA synthetase bcf_13095 ENOG4107VXM glycerophosphoryl diester phosphodiesterase bcf_13115 ENOG4107Y9U Membrane bcf_13155 ENOG4105FCD Major Facilitator bcf_13160 ENOG4105E09 nadh pyrophosphatase bcf_13165 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) bcf_13170 ENOG4108Z4K mutator MutT protein bcf_13190 ENOG4108XI2 Domain of unknown function (DUF1963) bcf_13215 ENOG4108NRW Phospholipase, patatin family bcf_13220 ENOG4105KWG Pfam:DUF1696 bcf_13260 ENOG4105PKS Excinuclease abc c subunit domain protein bcf_13300 ENOG4107VFR oxidoreductase bcf_13325 ENOG4105U0R haloacid dehalogenase-like hydrolase bcf_13350 ENOG4108IUM Glycogen debranching enzyme bcf_13355 ENOG4108IUM Glycogen debranching enzyme bcf_13380 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) bcf_13385 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) bcf_13395 ENOG4105FDR Membrane bcf_13450 ENOG4105MSI germination protein ypeb bcf_13485 ENOG4107Z3H Transcriptional regulator, TetR family bcf_13515 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family bcf_13530 ENOG4108MK9 spermidine N(1)-acetyltransferase bcf_13535 ENOG4105E98 transcriptional regulator DeoR family bcf_13555 ENOG41062ES Transcriptional regulator bcf_13575 ENOG4107QKR Dehydrogenase bcf_13585 ENOG4107RUY (E1 component), alpha subunit bcf_13595 ENOG4105E1F short-chain dehydrogenase reductase bcf_13600 ENOG4105RHY Pfam:UPF0157 bcf_13605 ENOG4105DBI uridine monophosphokinase bcf_13615 ENOG4105M6F mutator MutT protein bcf_13645 ENOG4108IJ7 Glycine betaine bcf_13670 ENOG4105E66 phosphoriboisomerase A bcf_13675 ENOG41082BV acetyltransferase bcf_13680 ENOG4108M1A Chitin-binding protein bcf_13700 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) bcf_13705 ENOG4105MSB protein, conserved in bacteria bcf_13710 ENOG4107YB6 acetyltransferase, (GNAT) family bcf_13715 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 bcf_13745 ENOG4108Z7F N-acetyltransferase bcf_13765 ENOG4105EEM helicase bcf_13785 ENOG4105C9U ATP-dependent DNA helicase RecQ bcf_13835 ENOG4108M1A Chitin-binding protein bcf_13850 ENOG4105BZG amino acid carrier protein bcf_13855 ENOG4105C26 Dehydrogenase bcf_13860 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) bcf_13865 ENOG4105CTU Proline racemase bcf_13870 ENOG4105CTU Proline racemase bcf_13875 ENOG41080HI glycine oxidase bcf_13885 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein bcf_13915 ENOG4107T5V SNARE associated Golgi bcf_13925 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD bcf_13930 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) bcf_13945 ENOG4105DTQ mandelate racemase muconate lactonizing bcf_13990 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) bcf_13995 ENOG4105BZU Histidine kinase bcf_14000 ENOG4105CK6 Two component transcriptional regulator (Winged helix family bcf_14030 ENOG4105DPN Oligoendopeptidase f bcf_14035 ENOG4105DVH amino acid bcf_14045 ENOG4105EPR degv family bcf_14100 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) bcf_14105 ENOG4106K7D Major facilitator family transporter bcf_14125 ENOG4107BMA Transglycosylase associated protein bcf_14140 ENOG41089UC methyltransferase, type 11 bcf_14170 ENOG4105CHM Aminotransferase bcf_14185 ENOG4108ZMI UPF0477 protein bcf_14200 ENOG4105DVE abc transporter atp-binding protein bcf_14240 ENOG4105C02 permease bcf_14250 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) bcf_14255 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component bcf_14260 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein bcf_14275 ENOG4105E09 nadh pyrophosphatase bcf_14295 ENOG4108AQF aminoglycoside N(3)-acetyltransferase bcf_14375 ENOG4108ZCF integral membrane protein bcf_14380 ENOG4105E0M Sulfatase bcf_14385 ENOG4105C5H ABC transporter bcf_14395 ENOG4105EYF MMPL domain protein bcf_14400 ENOG41082JN Transcriptional regulator bcf_14420 ENOG4105CIH Imidazole acetol-phosphate transaminase bcf_14430 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase bcf_14470 ENOG41069ER domain protein bcf_14480 ENOG4105CY2 Citrate transporter bcf_14485 ENOG4105E39 Enoyl-CoA hydratase bcf_14490 ENOG4105J5T Amp-dependent synthetase and ligase bcf_14495 ENOG4108JUB Transcriptional regulator bcf_14510 ENOG4105D4B ABC, transporter bcf_14515 ENOG4105F5R ABC transporter bcf_14520 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane bcf_14530 ENOG4105DKT Transcriptional regulator bcf_14535 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) bcf_14545 ENOG41061GT Aldolase bcf_14575 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) bcf_14610 ENOG4105II7 pyrroline-5-carboxylate reductase bcf_14630 ENOG4107258 Transcriptional regulator bcf_14640 ENOG4105E0Y RtcB Protein bcf_14645 ENOG4105ECK Fatty Acid Desaturase bcf_14650 ENOG4105G6Z alkaline phosphatase bcf_14660 ENOG4105VMP Transcriptional regulator bcf_14675 ENOG41090T1 Membrane bcf_14685 ENOG4108WCX response regulator bcf_14695 ENOG41068WN bcf_14725 ENOG4105C7R Atpase associated with various cellular activities aaa_3 bcf_14760 ENOG4105CKK Glycosyl transferase, family 2 bcf_14770 ENOG4105C8Y Acetylornithine aminotransferase bcf_14775 ENOG4105CH6 catalase bcf_14815 ENOG4108TVJ Nitroreductase bcf_14820 ENOG4105FS7 Transcriptional regulator bcf_14855 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family bcf_14870 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) bcf_14905 ENOG4108XET gCN5-related N-acetyltransferase bcf_14965 ENOG410635A Membrane bcf_14970 ENOG4105KNA -acetyltransferase bcf_14975 ENOG4108IQI permease bcf_14985 ENOG4105F1N DNA alkylation repair bcf_15015 ENOG4107RF6 penicillin-binding protein bcf_15025 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) bcf_15055 ENOG4105P4J Allophanate hydrolase, subunit 1 bcf_15060 ENOG4107258 Transcriptional regulator bcf_15070 ENOG4106N3A copper homeostasis protein cutc bcf_15080 ENOG4108ZRV stage ii sporulation protein p bcf_15085 ENOG4108ZHR arsR family transcriptional regulator bcf_15095 ENOG4105FDT acyl-CoA dehydrogenase bcf_15115 ENOG4105DWD nucleoside recognition domain protein bcf_15150 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) bcf_15220 ENOG4105E2A Dehydrogenase bcf_15230 ENOG4108IJ0 Aspartate ammonia-lyase bcf_15235 ENOG4105HDK L-asparaginase bcf_15240 ENOG4108IMY Transcriptional regulator bcf_15260 ENOG4108B31 Spore germination protein bcf_15275 ENOG4105BZU Histidine kinase bcf_15300 ENOG41075H3 AraC family transcriptional regulator bcf_15310 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) bcf_15315 ENOG4105CUB amino acid bcf_15325 ENOG4105II7 pyrroline-5-carboxylate reductase bcf_15335 ENOG4105C6K Malic enzyme bcf_15345 ENOG4108NHD germination protein bcf_15350 ENOG4108Q8B Spore germination protein bcf_15375 ENOG4105CSV Glutaminase bcf_15410 ENOG4105CGH 5'-nucleotidase bcf_15415 ENOG41061CK Antibiotic biosynthesis monooxygenase bcf_15460 ENOG4108606 TspO/MBR family bcf_15465 ENOG4105CVP deoxyribo-dipyrimidine photolyase bcf_15515 ENOG4105F2M alpha beta hydrolase fold-3 domain protein bcf_15530 ENOG4108TWJ NADH dehydrogenase subunit 5 bcf_15535 ENOG4105GPN Uncharacterized conserved protein (DUF2294) bcf_15550 ENOG4105C7R Atpase associated with various cellular activities aaa_3 bcf_15555 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase bcf_15560 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) bcf_15570 ENOG4105C19 ABC transporter bcf_15580 ENOG4105EWM Histidine kinase bcf_15585 ENOG4108NEV two component transcriptional regulator, LytTR family bcf_15590 ENOG4105DSE periplasmic solute binding protein bcf_15595 ENOG4105CC5 ABC transporter bcf_15600 ENOG4105DIK (ABC) transporter bcf_15625 ENOG4105D6J arsenicaL-resistance protein bcf_15630 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase bcf_15635 ENOG41085FC arsR family transcriptional regulator bcf_15650 ENOG4105F7F Chaperone bcf_15685 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) bcf_15690 ENOG4105C0R drug resistance transporter emrb qaca subfamily bcf_15700 ENOG4105IIP Membrane bcf_15715 ENOG4105CK6 Two component transcriptional regulator (Winged helix family bcf_15720 ENOG41062D9 Histidine kinase bcf_15745 ENOG4105K6H D-cysteine desulfhydrase bcf_15775 ENOG4108NNI Beta-lactamase domain-containing protein bcf_15780 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase bcf_15790 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) bcf_15805 ENOG4105C88 aminopeptidase bcf_15840 ENOG4105C4R Atp-dependent dna helicase bcf_15860 ENOG4105JQZ Methyltransferase bcf_15880 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) bcf_15895 ENOG4105BZU Histidine kinase bcf_15910 ENOG4108U05 Transcriptional regulator bcf_15915 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 bcf_15925 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) bcf_15940 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A bcf_15960 ENOG4105CEP NADH dehydrogenase bcf_15975 ENOG4108QXE glycerophosphoryl diester phosphodiesterase bcf_16010 ENOG4106ANW SMI1_KNR4 bcf_16045 ENOG4105TRI Hydrolase bcf_16075 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) bcf_16100 ENOG4105C44 Serine transporter bcf_16105 ENOG4105EJQ L-serine dehydratase bcf_16115 ENOG4105MZU cell filamentation protein bcf_16120 ENOG4108JPW Aminotransferase bcf_16135 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) bcf_16145 ENOG4105DVH amino acid bcf_16165 ENOG4108JQ1 Dehydrogenase bcf_16185 ENOG41082W1 Cupin 2, conserved barrel domain protein bcf_16190 ENOG410874W AraC family transcriptional regulator bcf_16205 ENOG4108IBT Inherit from COG: transposase bcf_16220 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase bcf_16260 ENOG4108ISG Major Facilitator bcf_16270 ENOG4107MII Sugar-specific transcriptional regulator TrmB bcf_16275 ENOG4105CZM Major Facilitator bcf_16295 ENOG4105DA5 (ABC) transporter bcf_16300 ENOG41069JR bcf_16310 ENOG4105RXJ bcf_16315 ENOG4105KPY Small multidrug resistance protein bcf_16320 ENOG4105KBX Transcriptional regulator, TetR family bcf_16325 ENOG4107AUC bcf_16340 ENOG4105CRW Short chain fatty acid transporter bcf_16345 ENOG4105DYS nad(p)h dehydrogenase (quinone) bcf_16380 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) bcf_16425 ENOG4107TXC Transcriptional regulator bcf_16445 ENOG4105DSE periplasmic solute binding protein bcf_16450 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family bcf_16465 ENOG4108Z66 YbaK ebsC protein bcf_16475 ENOG4105WH1 Two component transcriptional regulator luxr family bcf_16495 ENOG4105KVH Transcriptional regulator bcf_16500 ENOG4108RCM Nitroreductase bcf_16525 ENOG4108PSK reductase bcf_16535 ENOG4105CJ1 ABC, transporter bcf_16565 ENOG4105D7V transposase bcf_16610 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase bcf_16615 ENOG4105DKQ ROK family bcf_16620 ENOG4108UW5 maltose o-acetyltransferase bcf_16645 ENOG4105DMQ Methyltransferase bcf_16655 ENOG4105EV4 Multidrug resistance protein mdtH bcf_16685 ENOG4105C37 (CBS) domain bcf_16700 ENOG4105DDN Pentapeptide repeat-containing protein bcf_16705 ENOG4105XDF Protein of unknown function (DUF1272) bcf_16710 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) bcf_16715 ENOG4105CMG Carbohydrate kinase bcf_16720 ENOG4105C6Z Gluconate bcf_16725 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) bcf_16740 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase bcf_16745 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase bcf_16785 ENOG4105C44 Serine transporter bcf_16815 ENOG4108TZY GntR Family Transcriptional Regulator bcf_16820 ENOG4105D9R oxidoreductase bcf_16855 ENOG4105JAB phenazine biosynthesis protein, phzf family bcf_16875 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein bcf_16880 ENOG4105KVH Transcriptional regulator bcf_16890 ENOG4108ZJ4 polysaccharide deacetylase bcf_16995 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) bcf_17000 ENOG4105D7V transposase bcf_17015 ENOG4107YXZ hydrolase, family 25 bcf_17050 ENOG4105H3G oxidoreductase bcf_17125 ENOG4108TN2 lmbE family bcf_17135 ENOG4107R3E Citrate transporter bcf_17150 ENOG4108MES Periplasmic binding protein bcf_17155 ENOG4105EHG Permease protein bcf_17160 ENOG4105DQ5 transport system permease protein bcf_17165 ENOG4105NX3 Membrane bcf_17170 ENOG4107ZY0 Phenazine biosynthesis-like protein bcf_17190 ENOG4107V2S Transcriptional regulator bcf_17210 ENOG4105C98 muts2 protein bcf_17225 ENOG4105E5K Alpha-amylase bcf_17230 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase bcf_17235 ENOG4105DPN Oligoendopeptidase f bcf_17240 ENOG4108A04 Beta-lactamase bcf_17270 ENOG4107VXM glycerophosphoryl diester phosphodiesterase bcf_17300 ENOG41082BM Transcriptional regulator, arsr family bcf_17305 ENOG4105CIS alcohol dehydrogenase bcf_17330 ENOG4105RHY Pfam:UPF0157 bcf_17340 ENOG4105C09 Bile acid bcf_17345 ENOG4105CQB FAD linked oxidase domain protein bcf_17365 ENOG4108UT6 Transferase hexapeptide repeat containing protein bcf_17375 ENOG4105K64 Glycosyl transferase, family 2 bcf_17380 ENOG4105E39 Enoyl-CoA hydratase bcf_17390 ENOG4105KT7 mgtC SapB transporter bcf_17400 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase bcf_17405 ENOG41073R8 VanW family bcf_17415 ENOG4108R1P bcf_17435 ENOG4105VEQ Cold shock protein bcf_17485 ENOG4105DQ6 Transposase bcf_17510 ENOG4105DR5 peptidase bcf_17515 ENOG41065S2 pneumococcal vaccine antigen bcf_17525 ENOG4107YXZ hydrolase, family 25 bcf_17530 ENOG4105DR5 peptidase bcf_17580 ENOG410904N short-chain dehydrogenase reductase bcf_17590 ENOG4106IQC argininosuccinate lyase bcf_17605 ENOG4108IA2 Sodium pantothenate symporter bcf_17610 ENOG4105RG0 Membrane bcf_17615 ENOG4105C26 Dehydrogenase bcf_17620 ENOG4105CHR reductase bcf_17630 ENOG4105EWU Squalene--hopene cyclase bcf_17640 ENOG4105FR1 rard protein bcf_17645 ENOG410696E Membrane bcf_17660 ENOG4105D1F ATP-binding protein bcf_17670 ENOG4108ZAF Molybdopterin bcf_17675 ENOG4105CVM Molybdenum cofactor synthesis domain protein bcf_17680 ENOG4105D06 uba thif-type nad fad binding protein bcf_17685 ENOG4105TMB Formate nitrite transporter bcf_17695 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) bcf_17700 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) bcf_17710 ENOG4108JB9 formate dehydrogenase bcf_17720 ENOG4105E1K spore germination protein bcf_17780 ENOG4107QJT sodium dicarboxylate symporter bcf_17785 ENOG4108KGH TRANSCRIPTIONal bcf_17795 ENOG4105EMN RNA polymerase sigma factor bcf_17815 ENOG4105CIG ABC transporter bcf_17825 ENOG4105D9R oxidoreductase bcf_17840 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) bcf_17845 ENOG4105K4P CoA-binding domain protein bcf_17850 ENOG4105C0H protease bcf_17855 ENOG4105CK6 Two component transcriptional regulator (Winged helix family bcf_17865 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase bcf_17880 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) bcf_17885 ENOG4105W8X HesB YadR YfhF-family protein bcf_17915 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) bcf_17925 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen bcf_17935 ENOG4108JJA ABC, transporter bcf_17940 ENOG4108I0Z Aconitate hydratase bcf_17970 ENOG4105E5W Transporter bcf_17980 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) bcf_18000 ENOG4107F3J Amp-dependent synthetase and ligase bcf_18005 ENOG4107ZYJ bioY protein bcf_18010 ENOG4105CEY Amp-dependent synthetase and ligase bcf_18060 ENOG4107AYK membrAne bcf_18070 ENOG4105BZU Histidine kinase bcf_18075 ENOG4105FBA Phospholipase Carboxylesterase bcf_18080 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase bcf_18085 ENOG4105CK7 Sodium proline symporter bcf_18090 ENOG4105CBC glutamate synthase bcf_18095 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase bcf_18100 ENOG4108VJ1 Transcriptional regulator (CarD family bcf_18105 ENOG4108903 Formimidoylglutamase bcf_18130 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) bcf_18195 ENOG4107QIV Cytochrome c biogenesis protein bcf_18205 ENOG4105CH2 amidohydrolase bcf_18215 ENOG4105CJ1 ABC, transporter bcf_18225 ENOG4107RSM transcriptional regulator bcf_18235 ENOG41067MG lrgb family bcf_18260 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase bcf_18275 ENOG4105BZ1 (ABC) transporter bcf_18280 ENOG4105BZ1 (ABC) transporter bcf_18320 ENOG4105CGH 5'-nucleotidase bcf_18330 ENOG4108SVB resolvase bcf_18350 ENOG4105K7K Transcriptional regulator bcf_18360 ENOG4105C5F glutamine synthetase bcf_18365 ENOG4105KV4 Transcriptional regulator bcf_18370 ENOG4105CXI aluminum resistance protein bcf_18375 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) bcf_18380 ENOG4105EN6 Membrane bcf_18390 ENOG4106F1P AAA ATPase, central domain protein bcf_18420 ENOG41069ER domain protein bcf_18425 ENOG4105DM4 PTS System bcf_18430 ENOG4105DE4 1-phosphofructokinase bcf_18435 ENOG4105E98 transcriptional regulator DeoR family bcf_18440 ENOG4107QW4 alcohol dehydrogenase bcf_18445 ENOG4108SJC Membrane bcf_18460 ENOG4105C85 amino acid bcf_18480 ENOG4105TMB Formate nitrite transporter bcf_18485 ENOG4105K70 DNA-binding protein bcf_18490 ENOG4105C59 p-type ATPase bcf_18495 ENOG410681U heavy metal transport detoxification protein bcf_18500 ENOG4105VPX protein, conserved in bacteria bcf_18510 ENOG4105NIV Esterase bcf_18515 ENOG4105E0A ABC, transporter bcf_18540 ENOG4105CGK Exodeoxyribonuclease III bcf_18550 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) bcf_18555 ENOG4105D03 DNA-3-methyladenine glycosylase II bcf_18590 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase bcf_18595 ENOG4105BZU Histidine kinase bcf_18620 ENOG41067MG lrgb family bcf_18635 ENOG4108XEP Alpha Beta Hydrolase Fold protein bcf_18640 ENOG4107YEI lmbE family bcf_18665 ENOG4105F0V Cell wall hydrolase bcf_18675 ENOG4105E0M Sulfatase bcf_18680 ENOG410890F Dynamin family bcf_18690 ENOG4107QHE Choloylglycine hydrolase bcf_18720 ENOG4105DQU oxidoreductase, subunit beta bcf_18725 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein bcf_18730 ENOG4108IGT Dipeptidase bcf_18735 ENOG4105MCT stage V sporulation protein S bcf_18740 ENOG4105D48 metallophosphoesterase bcf_18760 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase bcf_18780 ENOG4105XZV Protein of unknown function (DUF3243) bcf_18785 ENOG4108RKS Short-chain dehydrogenase reductase Sdr bcf_18805 ENOG4105UIB (ABC) transporter bcf_18810 ENOG4108JQ9 ABC transporter bcf_18815 ENOG4105DIH basic membrane bcf_18820 ENOG4105DIH basic membrane bcf_18825 ENOG4105FDP GntR family transcriptional regulator bcf_18830 ENOG4107QZI cell division protein FtsK bcf_18840 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit bcf_18855 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) bcf_18865 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) bcf_18870 ENOG4108S0H Dipicolinic acid synthetase, b subunit bcf_18875 ENOG4105E35 Dipicolinate synthase subunit A bcf_18885 ENOG4105C1V Peptidase, M16 bcf_18905 ENOG4105DTN riboflavin biosynthesis protein ribF bcf_18920 ENOG4105W7A Protein of unknown function (DUF503) bcf_18930 ENOG4105VHM ribosomal protein bcf_18935 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination bcf_18940 ENOG4105CHV Transcription elongation factor NusA bcf_18950 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) bcf_18955 ENOG4105EKQ RNA-directed DNA polymerase bcf_18960 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) bcf_18970 ENOG4105DZP Membrane-associated zinc metalloprotease bcf_18975 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) bcf_18980 ENOG4105KNE Phosphatidate cytidylyltransferase bcf_19025 ENOG4108HE4 integrase family bcf_19035 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) bcf_19040 ENOG4105C79 DNA protecting protein DprA bcf_19045 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha bcf_19060 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) bcf_19100 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) bcf_19105 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) bcf_19120 ENOG4105CHR reductase bcf_19125 ENOG4105CHR reductase bcf_19130 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase bcf_19145 ENOG4105CB5 ATP-dependent DNA helicase recG bcf_19150 ENOG4105DP4 dak2 domain fusion protein ylov bcf_19155 ENOG4108ZAA Alkaline-shock protein bcf_19165 ENOG4105FJ0 thiamine bcf_19170 ENOG4105DJV ribulose-phosphate 3-epimerase bcf_19175 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) bcf_19180 ENOG4105D9P serine threonine protein kinase bcf_19185 ENOG4108ZF3 Phosphatase bcf_19195 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B bcf_19205 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) bcf_19210 ENOG4105C25 Primosomal protein n' bcf_19215 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase bcf_19235 ENOG4105DSJ YicC domain protein bcf_19245 ENOG4105F23 Fibronectin-binding protein bcf_19250 ENOG4105DC7 peptidase M24 bcf_19310 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain bcf_19335 ENOG4105C34 Pseudouridine synthase bcf_19360 ENOG4105DBK s4 domain protein bcf_19365 ENOG41067XK integral membrane protein bcf_19375 ENOG4105DFA alanine racemase domain protein bcf_19380 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase bcf_19385 ENOG4105WR5 sporulation protein, YlmC YmxH family bcf_19395 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) bcf_19400 ENOG4105FFI sigma-e processing peptidase spoiiga bcf_19405 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) bcf_19410 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) bcf_19415 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) bcf_19420 ENOG4105D4A Cell wall formation (By similarity) bcf_19425 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) bcf_19430 ENOG4105CNI cell division protein FtsW bcf_19445 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) bcf_19450 ENOG4105CJN penicillin-binding protein bcf_19455 ENOG4105CJN penicillin-binding protein bcf_19460 ENOG41068DC Essential cell division protein (By similarity) bcf_19495 ENOG4105KNH Nucleic acid-binding protein bcf_19505 ENOG41063PX domain protein bcf_19510 ENOG4105D78 K07001 NTE family protein bcf_19515 ENOG4105H20 Sporulation integral membrane protein YlbJ bcf_19525 ENOG4106H78 methyltransferase bcf_19545 ENOG4107TB6 phosphoglycerate mutase bcf_19560 ENOG4106UY4 Inherit from COG: Scp-like extracellular bcf_19610 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) bcf_19615 ENOG4105CNI cell division protein FtsW bcf_19630 ENOG4108IAB Phoh family bcf_19650 ENOG4105QA2 bcf_19655 ENOG4105CI3 gtp-binding protein typa bcf_19665 ENOG4105ECY inositol monophosphatase bcf_19685 ENOG4105CXN decarboxylase bcf_19730 ENOG4105CPP Dehydrogenase, E1 component bcf_19745 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) bcf_19750 ENOG4108X4Q Hydrolase bcf_19760 ENOG4105CN5 Metallo-Beta-Lactamase bcf_19765 ENOG4107ZYR domain protein bcf_19800 ENOG4108XRC Protein of unknown function (DUF458) bcf_19810 ENOG4107IN1 Protein of unknown function (DUF1797) bcf_19830 ENOG4105EPM Diguanylate phosphodiesterase bcf_19835 ENOG4105K6S Short-chain dehydrogenase reductase Sdr bcf_19850 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) bcf_19860 ENOG4105UIN bcf_19920 ENOG4108HGU Histidine kinase bcf_19930 ENOG4105CHM Aminotransferase bcf_19935 ENOG4105FKQ transcriptional regulator bcf_19945 ENOG4105EG2 ABC transporter, permease bcf_19955 ENOG4107FKK extracellular solute-binding protein family 1 bcf_19965 ENOG4105CG3 alpha amylase, catalytic region bcf_20010 ENOG4105CHU acetyl-coa acetyltransferase bcf_20040 ENOG4105K7K Transcriptional regulator bcf_20045 ENOG4105DTD Dehydrogenase bcf_20065 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase bcf_20105 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase bcf_20110 ENOG4106TD9 Diguanylate cyclase bcf_20130 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) bcf_20145 ENOG4105CID antiterminator bcf_20155 ENOG4105FDP GntR family transcriptional regulator bcf_20165 ENOG4105CE4 GlcNAc 6-P deacetylase bcf_20200 ENOG4107ZE5 PPIases accelerate the folding of proteins bcf_20205 ENOG4105PTM secreted protein bcf_20210 ENOG4105J7I hydrolase bcf_20220 ENOG4105G6R Stage v sporulation protein ae bcf_20230 ENOG4105CZ3 stage V sporulation protein ad bcf_20235 ENOG41090VF Stage v sporulation protein ac bcf_20255 ENOG4105C8J )-transporter bcf_20260 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) bcf_20270 ENOG41082AN stage II sporulation protein bcf_20275 ENOG4105DZ1 carboxypeptidase bcf_20280 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family bcf_20285 ENOG4105DVE abc transporter atp-binding protein bcf_20320 ENOG4105D7N magnesium and cobalt transport protein CorA bcf_20345 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) bcf_20355 ENOG4105I3K Ferric uptake regulator, Fur family bcf_20360 ENOG4105MZ9 stage II sporulation protein m bcf_20380 ENOG4105CPC Aldo Keto reductase bcf_20390 ENOG4105RHY Pfam:UPF0157 bcf_20410 ENOG4107SKW Inherit from COG: Alpha beta hydrolase bcf_20420 ENOG4105ETE Transcriptional regulator (LacI family bcf_20425 ENOG4108YM7 Gcn5-related n-acetyltransferase bcf_20445 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) bcf_20450 ENOG4108R6K riboflavin synthase, subunit alpha bcf_20475 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) bcf_20480 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) bcf_20495 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) bcf_20510 ENOG4105DFD Na H antiporter bcf_20515 ENOG4105CGH 5'-nucleotidase bcf_20555 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) bcf_20570 ENOG4108IXY short-chain dehydrogenase reductase bcf_20575 ENOG41069FQ Metallo-beta-lactamase superfamily bcf_20580 ENOG4105II7 pyrroline-5-carboxylate reductase bcf_20585 ENOG4105EJQ L-serine dehydratase bcf_20610 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) bcf_20615 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) bcf_20620 ENOG4105D9U N-acetyltransferase bcf_20630 ENOG4108VZI ErfK ybiS ycfS ynhG family protein bcf_20635 ENOG4108QEG Membrane bcf_20640 ENOG4105CDA abc transporter atp-binding protein bcf_20645 ENOG4105E5Q amino acid AbC transporter bcf_20650 ENOG4108HW3 (ABC) transporter bcf_20660 ENOG4105G7B Protein of unknown function (DUF2992) bcf_20665 ENOG4105E09 nadh pyrophosphatase bcf_20675 ENOG4105C7S Dehydrogenase bcf_20680 ENOG4105CPP Dehydrogenase, E1 component bcf_20700 ENOG4107RDP Dehydrogenase bcf_20710 ENOG4108JUB Transcriptional regulator bcf_20720 ENOG4108QXE glycerophosphoryl diester phosphodiesterase bcf_20735 ENOG4107QQR Sporulation bcf_20740 ENOG4105S1Z Stage IV sporulation protein B bcf_20745 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) bcf_20755 ENOG4105DX0 Hemolysin A bcf_20765 ENOG4105CTB Polyprenyl synthetase bcf_20790 ENOG4108ZSR alkaline shock protein bcf_20795 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase bcf_20820 ENOG410644B Stage III sporulation protein af bcf_20830 ENOG4105KQ4 Stage iii sporulation protein ad bcf_20835 ENOG4108CQH stage III sporulation protein AC bcf_20840 ENOG4105KR5 Stage iii sporulation protein bcf_20845 ENOG4105CD2 stage iii sporulation protein aa bcf_20865 ENOG4105DC7 peptidase M24 bcf_20880 ENOG4105CBJ Metal-dependent enzyme bcf_20890 ENOG4107YBY Hydrolase bcf_20905 ENOG4105K7K Transcriptional regulator bcf_20925 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) bcf_20930 ENOG4105WZW rhodanese family bcf_20950 ENOG41080TC multidrug resistance protein bcf_20985 ENOG4105CJ1 ABC, transporter bcf_20990 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family bcf_21020 ENOG4105C0D helicase bcf_21150 ENOG4105C3R Methionine synthase bcf_21160 ENOG4105C28 cystathionine bcf_21165 ENOG4105C28 cystathionine bcf_21185 ENOG4105C5X domain protein bcf_21195 ENOG4105DKQ ROK family bcf_21205 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase bcf_21220 ENOG4108UTW Plays a role in the regulation of phosphate uptake bcf_21225 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) bcf_21230 ENOG4105E2Z phosphate ABC transporter (Permease bcf_21235 ENOG4105C8U phosphate abc transporter bcf_21240 ENOG4105PWN phosphate abc transporter bcf_21245 ENOG4107RF6 penicillin-binding protein bcf_21255 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) bcf_21280 ENOG4105N80 Ferric uptake regulator, Fur family bcf_21290 ENOG4105FDK ABC transporter bcf_21295 ENOG4108JYZ YitT family bcf_21300 ENOG41069ZM Protein of unknown function (DUF2624) bcf_21325 ENOG4105EGD dinuclear metal center protein, YbgI family bcf_21340 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) bcf_21345 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) bcf_21380 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) bcf_21385 ENOG4105KG3 cytidine deaminase bcf_21390 ENOG4107YR5 Diacylglycerol kinase bcf_21400 ENOG4105CTJ Metal Dependent Phosphohydrolase bcf_21405 ENOG4105C9A Phoh family bcf_21415 ENOG41068P3 sporulation protein YqfC bcf_21420 ENOG4105KTH gatB Yqey bcf_21430 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) bcf_21435 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) bcf_21455 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ bcf_21465 ENOG4105CSA Coproporphyrinogen iii oxidase bcf_21470 ENOG4105KVH Transcriptional regulator bcf_21500 ENOG4105TQK DNA polymerase iii, delta' subunit bcf_21510 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 bcf_21515 ENOG4108UK2 deaminase bcf_21520 ENOG4105KQC Competence protein bcf_21530 ENOG4105DXX methyltransferase bcf_21540 ENOG4108WF2 Metal Dependent Phosphohydrolase bcf_21550 ENOG410812S Rna-binding protein bcf_21560 ENOG4105CQW ribosome biogenesis GTPase YqeH bcf_21565 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase bcf_21580 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) bcf_21600 ENOG4108TVJ Nitroreductase bcf_21615 ENOG4105G6Z alkaline phosphatase bcf_21630 ENOG4108MUZ hydrolase bcf_21665 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin bcf_21675 ENOG4105MIR Phenylalanine 4-monooxygenase bcf_21685 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase bcf_21725 ENOG4105S6R Iron-hydroxamate transporter permease subunit bcf_21730 ENOG4108V5C ABC transporter bcf_21740 ENOG4108EKI Dehydrogenase bcf_21745 ENOG4105C28 cystathionine bcf_21775 ENOG4107XRG penicillin-binding protein bcf_21790 ENOG4105CFP Peptidase U32 bcf_21795 ENOG4105XYU peptidase (U32 family) bcf_21800 ENOG4108VQJ O-methyltransferase bcf_21805 ENOG4105HHA aminodeoxychorismate lyase bcf_21835 ENOG4105C02 permease bcf_21850 ENOG41060CR bcf_21855 ENOG4105C7H Helicase, RecD TraA family bcf_21870 ENOG4105C3J Cysteine desulfurase bcf_21880 ENOG4105D1H recombination factor protein RarA bcf_21885 ENOG4108VCI transcription factor, rsfa family bcf_21890 ENOG4105CUZ uba thif-type nad fad binding protein bcf_21900 ENOG4105CUT histidyl-tRNA synthetase bcf_21915 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) bcf_21925 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) bcf_21930 ENOG41076HS cation diffusion facilitator family transporter bcf_21935 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) bcf_21945 ENOG4105CKP Polysaccharide Biosynthesis Protein bcf_21950 ENOG4108QG2 Membrane bcf_21960 ENOG4105VIE preprotein translocase, subunit YajC bcf_21980 ENOG41061AI Protein of unknown function (DUF2905) bcf_21995 ENOG4108HUF Transporter bcf_22005 ENOG4108IPJ Membrane bcf_22010 ENOG41082BM Transcriptional regulator, arsr family bcf_22035 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase bcf_22040 ENOG4108IYU L-aspartate oxidase bcf_22055 ENOG4108RPX mosc domain containing protein bcf_22060 ENOG4105CQC Prephenate dehydratase bcf_22080 ENOG4105EWM Histidine kinase bcf_22105 ENOG4105X36 (ribosomal) protein bcf_22115 ENOG4105C03 ribonuclease bcf_22130 ENOG4107QMS site-determining protein bcf_22145 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) bcf_22150 ENOG4105DFF Rod shape-determining protein mreb bcf_22215 ENOG4105W5Q DNA repair protein (RadC bcf_22260 ENOG41082EK Restriction modification system DNA (Specificity bcf_22295 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase bcf_22300 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) bcf_22310 ENOG41068KH stage VI sporulation protein D bcf_22320 ENOG4105D52 delta-aminolevulinic acid dehydratase bcf_22345 ENOG4105K56 Transcriptional regulator bcf_22365 ENOG4108IUQ atp-dependent protease bcf_22395 ENOG4108QCI YvbH-like oligomerisation region bcf_22420 ENOG4105M59 Phosphodiesterase, mj0936 family bcf_22425 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) bcf_22435 ENOG4108XJQ germination protein bcf_22445 ENOG4108PCX Major Facilitator bcf_22460 ENOG4105KBX Transcriptional regulator, TetR family bcf_22475 ENOG4105PFC Transcriptional regulator bcf_22490 ENOG4105DZC cytosine deaminase bcf_22495 ENOG4105DZC cytosine deaminase bcf_22500 ENOG4105DEF Extracellular solute-binding protein, family 5 bcf_22505 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component bcf_22520 ENOG4108JQ7 (ABC) transporter bcf_22525 ENOG4108HRK Histidine kinase bcf_22535 ENOG41067S9 phage shock protein C, PspC bcf_22540 ENOG4108JCI Transcriptional regulator bcf_22550 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) bcf_22560 ENOG4108Z40 Transcriptional regulator bcf_22565 ENOG4105RHA ABC transporter, permease bcf_22570 ENOG4108IUX (ABC) transporter bcf_22575 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family bcf_22580 ENOG4105ER2 Ompa motb domain protein bcf_22585 ENOG4105E14 MotA TolQ exbB proton channel bcf_22590 ENOG4108VXD carboxy-peptidase bcf_22600 ENOG4105E33 succinate dehydrogenase bcf_22610 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit bcf_22625 ENOG4105K63 Thioredoxin bcf_22630 ENOG4105C10 Electron transfer flavoprotein bcf_22635 ENOG4105BZJ Electron transfer flavoprotein bcf_22640 ENOG41060WC Enoyl-CoA hydratase bcf_22645 ENOG4107Z3H Transcriptional regulator, TetR family bcf_22650 ENOG4105CEY Amp-dependent synthetase and ligase bcf_22665 ENOG4105J76 Periplasmic binding protein bcf_22670 ENOG4105S6R Iron-hydroxamate transporter permease subunit bcf_22710 ENOG4105DPZ Two component transcriptional regulator (Winged helix family bcf_22725 ENOG4105DR4 Methyltransferase bcf_22740 ENOG4105KFN sortase, SrtB family bcf_22745 ENOG4105E0A ABC, transporter bcf_22760 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) bcf_22765 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) bcf_22775 ENOG4105FE9 pseudouridine synthase bcf_22785 ENOG4105DCG PHP domain protein bcf_22815 ENOG4105C5S asparaginyl-tRNA synthetase bcf_22820 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) bcf_22830 ENOG4108RWN rrna methyltransferase bcf_22875 ENOG4105C0R drug resistance transporter emrb qaca subfamily bcf_22880 ENOG4105CW7 secretion protein, HlyD family bcf_22885 ENOG4108JGH Tetr family transcriptional regulator bcf_22890 ENOG4105CN9 Peptidase m42 family protein bcf_22915 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) bcf_22920 ENOG4105C22 threonyL-tRNA synthetase bcf_22925 ENOG4108TDW sporulation protein YtxC bcf_22945 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) bcf_22955 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase bcf_22960 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) bcf_22970 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) bcf_22975 ENOG4105C2M dna polymerase I bcf_22980 ENOG4105BZU Histidine kinase bcf_22985 ENOG4105DPZ Two component transcriptional regulator (Winged helix family bcf_23005 ENOG4108HMX isocitrate dehydrogenase (NADP) bcf_23010 ENOG4105BZN citrate synthase bcf_23020 ENOG4108REF Sporulation integral membrane protein ytvi bcf_23025 ENOG4105FS0 cytoplasmic membrane protein bcf_23050 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family bcf_23055 ENOG4105C6K Malic enzyme bcf_23060 ENOG4105C0B DNA polymerase III (alpha subunit) bcf_23065 ENOG4105VV2 bcf_23075 ENOG4105SFS phosphoesterase RecJ domain protein bcf_23120 ENOG4105DC7 peptidase M24 bcf_23165 ENOG41082W1 Cupin 2, conserved barrel domain protein bcf_23175 ENOG4105VZ8 Transcriptional regulator bcf_23195 ENOG4107YZX Universal stress protein bcf_23240 ENOG4108JYZ YitT family bcf_23275 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) bcf_23280 ENOG4105KBJ sporulation protein ytfj bcf_23295 ENOG4105EFZ amidohydrolase bcf_23305 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) bcf_23330 ENOG4106KR7 LysR family Transcriptional regulator bcf_23340 ENOG4105U5Y Transcriptional regulator bcf_23350 ENOG4105C28 cystathionine bcf_23395 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) bcf_23410 ENOG4105F1V Acetoin utilization protein bcf_23415 ENOG4105W87 Cbs domain bcf_23420 ENOG4105DGU Histone deacetylase bcf_23435 ENOG4105DPZ Two component transcriptional regulator (Winged helix family bcf_23440 ENOG4105BZU Histidine kinase bcf_23445 ENOG4107SNB ankyrin repeat protein YahD bcf_23450 ENOG4105EP9 oxidoreductase bcf_23480 ENOG4105ETE Transcriptional regulator (LacI family bcf_23500 ENOG4105C88 aminopeptidase bcf_23540 ENOG4108VDD TRNA binding domain protein bcf_23570 ENOG4105C8F Beta-lactamase domain protein bcf_23585 ENOG4108V15 phosphotransferase enzyme family bcf_23590 ENOG4108IUM Glycogen debranching enzyme bcf_23600 ENOG4107QSE Dipeptidase bcf_23605 ENOG4105YW5 deoR family transcriptional regulator bcf_23620 ENOG4105CBX hi0933 family bcf_23660 ENOG4108VJ1 Transcriptional regulator (CarD family bcf_23665 ENOG4107EXU Short-chain dehydrogenase reductase Sdr bcf_23685 ENOG4108ZAF Molybdopterin bcf_23690 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein bcf_23695 ENOG4105CVM Molybdenum cofactor synthesis domain protein bcf_23705 ENOG4105D06 uba thif-type nad fad binding protein bcf_23710 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) bcf_23730 ENOG41085GJ domain protein bcf_23740 ENOG4105DWV Homoserine O-trans-acetylase bcf_23750 ENOG4108B31 Spore germination protein bcf_23785 ENOG410605W Major Facilitator bcf_23790 ENOG4107S91 Sodium hydrogen exchanger bcf_23795 ENOG4105NCW Trka-c domain protein bcf_23810 ENOG4105C19 ABC transporter bcf_23830 ENOG4105N5T Radical SAM Protein bcf_23840 ENOG4105CIG ABC transporter bcf_23880 ENOG4105E8V Alpha Beta Hydrolase Fold protein bcf_23885 ENOG4108Z0R Transferase bcf_23890 ENOG4105YVM Phosphoesterase, PA-phosphatase related bcf_23895 ENOG4105BZF Glycosyl transferase (Group 1 bcf_23905 ENOG4108RIR Molybdenum cofactor biosynthesis protein bcf_23955 ENOG4105EGD dinuclear metal center protein, YbgI family bcf_23960 ENOG4105BZU Histidine kinase bcf_23965 ENOG4105BZU Histidine kinase bcf_23970 ENOG4107S9D Alpha beta hydrolase bcf_23975 ENOG4107T7U Sulfatase bcf_23990 ENOG4105D2X ABC transporter substrate-binding protein bcf_24000 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component bcf_24015 ENOG4107XGZ Hydrolase bcf_24060 ENOG4108V2W Carbonate dehydratase bcf_24065 ENOG4105C4M (Ubiquinol oxidase) subunit I bcf_24070 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii bcf_24115 ENOG41087YS Phage shock protein A bcf_24155 ENOG4105N67 Proton-coupled thiamine transporter YuaJ bcf_24160 ENOG4105BZU Histidine kinase bcf_24165 ENOG4105CK6 Two component transcriptional regulator (Winged helix family bcf_24190 ENOG4108UGV hypoxanthine phosphoribosyltransferase bcf_24195 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) bcf_24205 ENOG4105D7V transposase bcf_24220 ENOG4107ZTW SNARE associated Golgi bcf_24235 ENOG4105C19 ABC transporter bcf_24240 ENOG41086D8 Transcriptional regulator bcf_24280 ENOG4105C6Z Gluconate bcf_24285 ENOG4105FDP GntR family transcriptional regulator bcf_24305 ENOG41069H0 dihydroorotase EC 3.5.2.3 bcf_24325 ENOG4105DTQ mandelate racemase muconate lactonizing bcf_24335 ENOG4108IPT Naphthoate synthase bcf_24340 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) bcf_24350 ENOG4105E4F Isochorismate synthase bcf_24355 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase bcf_24365 ENOG4105VEQ Cold shock protein bcf_24395 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) bcf_24410 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin bcf_24415 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) bcf_24510 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation bcf_24545 ENOG4105KT7 mgtC SapB transporter bcf_24550 ENOG4107PBV potassium channel bcf_24565 ENOG4105WG9 Conserved Protein bcf_24575 ENOG4105CHM Aminotransferase bcf_24580 ENOG4108ZB6 transcriptional regulator AsnC family bcf_24585 ENOG4105C5I Dehydrogenase bcf_24590 ENOG4108MUZ hydrolase bcf_24600 ENOG4105C87 Aminotransferase class I and II bcf_24615 ENOG4105Y38 Kinase-associated protein B bcf_24625 ENOG4107R3E Citrate transporter bcf_24640 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) bcf_24645 ENOG4105KA0 thioesterase Superfamily protein bcf_24660 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase bcf_24680 ENOG41069ER domain protein bcf_24695 ENOG4105CEP NADH dehydrogenase bcf_24725 ENOG4105EWC Purine nucleoside phosphorylase bcf_24735 ENOG4108YX9 iron--sulfur cluster insertion protein erpA bcf_24760 ENOG4108JJA ABC, transporter bcf_24765 ENOG4105C4B ABC transporter, permease bcf_24770 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA bcf_24795 ENOG41083MR nifu domain-containing protein bcf_24810 ENOG4108W5N phosphatidylglycerophosphatase a bcf_24825 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) bcf_24830 ENOG4105DYS nad(p)h dehydrogenase (quinone) bcf_24840 ENOG4105D4U had-superfamily hydrolase, subfamily iia bcf_24855 ENOG4105CBT Fructose-1,6-bisphosphatase bcf_24870 ENOG4105MMD transcriptional regulator bcf_24875 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) bcf_24880 ENOG4107TXC Transcriptional regulator bcf_24885 ENOG41090T1 Membrane bcf_24910 ENOG4105FAA peptidase M23 bcf_24920 ENOG4105KZD Domain of unknown function (DUF1805) bcf_24925 ENOG4107R8B 5'-nucleotidase bcf_24945 ENOG4105DIW FeS assembly protein SUFB bcf_24950 ENOG4108UNV SUF system FeS assembly protein, NifU family bcf_24955 ENOG4105C9B Cysteine desulfurase bcf_24960 ENOG4105JRK feS assembly protein SufD bcf_24965 ENOG4105C3K feS assembly ATPase SufC bcf_24970 ENOG4105D01 (LipO)protein bcf_24975 ENOG4105D01 (LipO)protein bcf_24980 ENOG4108UMI ABC transporter, permease bcf_25020 ENOG41080E8 Transcriptional regulator, Spx MgsR family bcf_25060 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) bcf_25090 ENOG4108W8B Beta-lactamase domain protein bcf_25095 ENOG4108IUW ABC transporter bcf_25120 ENOG4105C1G acyl-Coa dehydrogenase bcf_25125 ENOG4105CHU acetyl-coa acetyltransferase bcf_25140 ENOG4105DZ1 carboxypeptidase bcf_25160 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer bcf_25180 ENOG4108SUT Major Facilitator Superfamily bcf_25185 ENOG4107R7I amino acid bcf_25200 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins bcf_25210 ENOG4107AYK membrAne bcf_25250 ENOG4107ZTW SNARE associated Golgi bcf_25260 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein bcf_25265 ENOG4105CK6 Two component transcriptional regulator (Winged helix family bcf_25270 ENOG4105BZU Histidine kinase bcf_25290 ENOG4105C8Q Methyl-accepting chemotaxis bcf_25295 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer bcf_25300 ENOG4105VG1 fes assembly suf system protein bcf_25305 ENOG4105D4Y metalloprotease bcf_25325 ENOG4107S91 Sodium hydrogen exchanger bcf_25330 ENOG4105NCW Trka-c domain protein bcf_25340 ENOG4108RMU ferritin dps family protein bcf_25355 ENOG4108URH decarboxylase bcf_25375 ENOG4105D9N nucleoside bcf_25385 ENOG4105D9N nucleoside bcf_25390 ENOG4105D9N nucleoside bcf_25410 ENOG4108RYK Nad-dependent epimerase dehydratase bcf_25425 ENOG4105CV8 reductase bcf_25430 ENOG4105F27 Major Facilitator bcf_25435 ENOG4105KVH Transcriptional regulator bcf_25450 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) bcf_25455 ENOG4105D4A Cell wall formation (By similarity) bcf_25475 ENOG4105C8Q Methyl-accepting chemotaxis bcf_25485 ENOG4105WMR Protein CrcB homolog bcf_25510 ENOG4105C5H ABC transporter bcf_25515 ENOG4108MK9 spermidine N(1)-acetyltransferase bcf_25520 ENOG4108VY7 phosphate-starvation-inducible protein PsiE bcf_25535 ENOG4108IPW abc transporter atp-binding protein bcf_25540 ENOG4105CM4 permease protein bcf_25570 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) bcf_25575 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) bcf_25585 ENOG4105XZU Preprotein translocase, subunit SecG bcf_25590 ENOG41067MG lrgb family bcf_25640 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) bcf_25695 ENOG41090VF Stage v sporulation protein ac bcf_25700 ENOG4105CZ3 stage V sporulation protein ad bcf_25715 ENOG4105H67 Protein of unknown function (DUF421) bcf_25720 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) bcf_25725 ENOG4105KRI phosphocarrier protein (HPr bcf_25735 ENOG4105CHW UPF0052 protein bcf_25745 ENOG4108Z4K mutator MutT protein bcf_25755 ENOG4105C3M thioredoxin reductase bcf_25765 ENOG4108S4C acetyltransferase bcf_25785 ENOG41086DT Membrane protein of unknown function bcf_25835 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) bcf_25840 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) bcf_25855 ENOG4107TXC Transcriptional regulator bcf_25880 ENOG4105HMI Membrane bcf_25885 ENOG4105DUM transcriptional regulator, lysR family bcf_25895 ENOG4108WS4 fmn reductase bcf_25900 ENOG4105C5H ABC transporter bcf_25910 ENOG4105BZ1 (ABC) transporter bcf_25920 ENOG4105CN1 protease bcf_25925 ENOG4105CRP Part of the ABC transporter FtsEX involved in bcf_25930 ENOG4105CAK Cell division ATP-binding protein ftsE bcf_25945 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) bcf_25960 ENOG4105MS2 ribosomal subunit Interface protein bcf_25970 ENOG4105VEQ Cold shock protein bcf_25975 ENOG41081UC Inherit from COG: Competence protein bcf_25990 ENOG4105KVH Transcriptional regulator bcf_26000 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein bcf_26005 ENOG4108KGH TRANSCRIPTIONal bcf_26010 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase bcf_26015 ENOG4105C6Y Udp-glucose 6-dehydrogenase bcf_26020 ENOG4105ESV Glycosyl transferase, family 4 bcf_26030 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family bcf_26050 ENOG4105F8D glycoside hydrolase family 4 bcf_26055 ENOG4105VCP PTS System bcf_26060 ENOG4105CK1 PTS System bcf_26070 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) bcf_26095 ENOG4105VCP PTS System bcf_26105 ENOG4105VZJ PTS System bcf_26120 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily bcf_26145 ENOG4105ECB domain protein bcf_26150 ENOG4107RSM transcriptional regulator bcf_26185 ENOG4105DAA L-lactate bcf_26190 ENOG4105D7V transposase bcf_26200 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) bcf_26210 ENOG4105E0M Sulfatase bcf_26235 ENOG4107R8N Glycosyl transferase, family 2 bcf_26245 ENOG4105C94 Transporter bcf_26250 ENOG41069ER domain protein bcf_26275 ENOG4105KBK Zinc finger, swim domain protein bcf_26280 ENOG4105C0D helicase bcf_26310 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) bcf_26320 ENOG4107RBB ABC transporter, permease bcf_26325 ENOG4105C19 ABC transporter bcf_26345 ENOG4105CXY transporter bcf_26360 ENOG4105BZU Histidine kinase bcf_26365 ENOG4105CK6 Two component transcriptional regulator (Winged helix family bcf_26370 ENOG4105DG6 mannose-6-phosphate isomerase bcf_26375 ENOG4105DM4 PTS System bcf_26385 ENOG4105CMR udp-glucose 4-epimerase bcf_26395 ENOG4108KGH TRANSCRIPTIONal bcf_26400 ENOG4105DG6 mannose-6-phosphate isomerase bcf_26405 ENOG4105CJT Mannose-1-phosphate guanylyltransferase bcf_26410 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) bcf_26415 ENOG4108TJN glycosyl transferase group 1 bcf_26420 ENOG4105C6Y Udp-glucose 6-dehydrogenase bcf_26440 ENOG4105D3Q Sugar transferase bcf_26445 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase bcf_26450 ENOG4108RB3 Capsular polysaccharide biosynthesis protein bcf_26455 ENOG4107YJ4 chain length determinant protein bcf_26460 ENOG4105HTX biosynthesis protein bcf_26465 ENOG4107YJ4 chain length determinant protein bcf_26480 ENOG4105MT0 Sporulation transcriptional regulator spoiiid bcf_26490 ENOG4105FRN stage II sporulation protein bcf_26505 ENOG4105DY9 regulatoR bcf_26525 ENOG4106778 Protein of unknown function (DUF1146) bcf_26530 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) bcf_26535 ENOG4105C8S subunit m bcf_26540 ENOG4105D65 subunit l bcf_26565 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) bcf_26570 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain bcf_26580 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain bcf_26585 ENOG4105BZU Histidine kinase bcf_26640 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) bcf_26645 ENOG41062M3 atp synthase bcf_26680 ENOG4108YZG isomerase bcf_26695 ENOG4108VGI doxx family bcf_26700 ENOG4107XC4 flavin reductase domain protein, FMN-binding bcf_26725 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) bcf_26735 ENOG4108ZXQ stage ii sporulation protein r bcf_26740 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) bcf_26745 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) bcf_26765 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) bcf_26770 ENOG4105CBT Fructose-1,6-bisphosphatase bcf_26775 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) bcf_26815 ENOG4105C1G acyl-Coa dehydrogenase bcf_26820 ENOG4105C1G acyl-Coa dehydrogenase bcf_26825 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase bcf_26835 ENOG4105DF6 Fe-S oxidoreductase bcf_26850 ENOG4105BZU Histidine kinase bcf_26875 ENOG4105BZU Histidine kinase bcf_26880 ENOG4105KCT ABC transporter bcf_26885 ENOG4108M15 ABC transporter bcf_26890 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) bcf_26900 ENOG4105IIU Aminopeptidase bcf_26920 ENOG4105EMN RNA polymerase sigma factor bcf_26930 ENOG410684U Domain of unknown function (DUF1934) bcf_26955 ENOG4105CYW agmatinase bcf_26965 ENOG4105DXB Major Facilitator superfamily bcf_26970 ENOG4107SWG transcriptional regulator MERR family bcf_26980 ENOG4108QXE glycerophosphoryl diester phosphodiesterase bcf_26985 ENOG4105BZ4 penicillin-binding protein bcf_26990 ENOG4108XFG YwhD family bcf_26995 ENOG4108Z4T Peptidase M50 bcf_27000 ENOG41069HH 4-oxalocrotonate tautomerase bcf_27005 ENOG4105DCI Phosphohydrolase bcf_27010 ENOG4108MES Periplasmic binding protein bcf_27015 ENOG4105E0A ABC, transporter bcf_27020 ENOG4105EHG Permease protein bcf_27025 ENOG4105DQ5 transport system permease protein bcf_27035 ENOG4108VCI transcription factor, rsfa family bcf_27050 ENOG4108IJ2 phosphate acetyltransferase bcf_27070 ENOG4108VKI Cell wall hydrolase bcf_27090 ENOG4107SVH Potassium channel protein bcf_27100 ENOG410667J hydrolase bcf_27105 ENOG4105VCH membrane bcf_27115 ENOG4108TU7 Inherit from COG: (ABC) transporter bcf_27120 ENOG4105CJ1 ABC, transporter bcf_27125 ENOG41090WU lipolytic protein G-D-S-L family bcf_27140 ENOG4105D6E homoserine dehydrogenase bcf_27160 ENOG4108Y4K DNA-binding transcriptional activator bcf_27170 ENOG4105WH1 Two component transcriptional regulator luxr family bcf_27175 ENOG4105BZU Histidine kinase bcf_27180 ENOG4105DWF phosphomethylpyrimidine kinase bcf_27190 ENOG4105BZU Histidine kinase bcf_27195 ENOG4105VCD cytoplasmic protein bcf_27200 ENOG4105D22 carbon starvation protein bcf_27205 ENOG4105DY9 regulatoR bcf_27215 ENOG41079KZ Major Facilitator Superfamily bcf_27235 ENOG4105EN6 Membrane bcf_27240 ENOG4106YBV Methyl-accepting chemotaxis bcf_27250 ENOG4108S4H thioesterase Superfamily protein bcf_27260 ENOG4105JEU Glycosyl transferase, family 2 bcf_27265 ENOG4105C5H ABC transporter bcf_27280 ENOG4105CKK Glycosyl transferase, family 2 bcf_27285 ENOG41067SE Tetr family transcriptional regulator bcf_27295 ENOG4105E0X reductase bcf_27305 ENOG4106F5Q Membrane bcf_27320 ENOG4105DY9 regulatoR bcf_27325 ENOG4108HRK Histidine kinase bcf_27330 ENOG4107RGD Major Facilitator superfamily bcf_27345 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) bcf_27355 ENOG4105IW1 AmiS UreI transporter bcf_27365 ENOG4105CMR udp-glucose 4-epimerase bcf_27370 ENOG4108UT2 hemolysin iii bcf_27380 ENOG4105C1J atp-dependent rna helicase bcf_27395 ENOG4105DPN Oligoendopeptidase f bcf_27415 ENOG4105C0H protease bcf_27420 ENOG4105Q2H domain protein bcf_27435 ENOG4105BZU Histidine kinase bcf_27440 ENOG4105CK6 Two component transcriptional regulator (Winged helix family bcf_27470 ENOG4105CDU Replicative dna helicase bcf_27480 ENOG4105BZR domain protein bcf_27485 ENOG4108XMW Membrane bcf_27495 ENOG4108UUM single-stranded DNA-binding protein bcf_27505 ENOG4105C3G gtp-binding protein bcf_27510 ENOG4105VDK protein, conserved in bacteria bcf_27515 ENOG4105D8X mechanosensitive ion channel bcf_27520 ENOG4108ZDA Sporulation protein YyaC bcf_27525 ENOG4105FA0 parb-like partition protein bcf_27530 ENOG4107QJE Chromosome Partitioning Protein bcf_27560 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins bcf_27605 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) bcf_27645 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) bcf_27680 ENOG4106CVF DNA replication protein bcf_27730 ENOG4105WXW Antirepressor bcf_27800 ENOG4107QJE Chromosome Partitioning Protein bcf_27855 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) bcf_27880 ENOG4105XSJ toxin secretion phage lysis holin bcf_27930 ENOG41060SN bcf_27965 ENOG4106CGH Phage Mu protein F like protein bcf_27970 ENOG4108MDF Phage Portal Protein