locus-tag class description FOC74_00005 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FOC74_00045 ENOG4105C59 p-type ATPase FOC74_00050 ENOG4105VPX protein, conserved in bacteria FOC74_00055 ENOG4105DSE periplasmic solute binding protein FOC74_00085 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding FOC74_00170 ENOG4105K63 Thioredoxin FOC74_00180 ENOG4105EAB amino acid AbC transporter FOC74_00185 ENOG4105E5Q amino acid AbC transporter FOC74_00190 ENOG4105CDA abc transporter atp-binding protein FOC74_00200 ENOG4107R16 Multicopper oxidase FOC74_00205 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC74_00210 ENOG4105BZU Histidine kinase FOC74_00220 ENOG4108ZRV stage ii sporulation protein p FOC74_00275 ENOG4105D9M gamma-glutamylcysteine synthetase FOC74_00285 ENOG4105C4W S-formylglutathione hydrolase FOC74_00295 ENOG4105KVH Transcriptional regulator FOC74_00310 ENOG4105E1K spore germination protein FOC74_00315 ENOG4108B31 Spore germination protein FOC74_00335 ENOG4108QY0 Membrane FOC74_00350 ENOG4105CZ3 stage V sporulation protein ad FOC74_00355 ENOG41090VF Stage v sporulation protein ac FOC74_00370 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC74_00385 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FOC74_00425 ENOG41086D8 Transcriptional regulator FOC74_00445 ENOG4108W2Y isochorismatase FOC74_00455 ENOG4108NHD germination protein FOC74_00475 ENOG4107XGZ Hydrolase FOC74_00485 ENOG4105YWU small acid-soluble spore protein FOC74_00505 ENOG4107A6P FOC74_00515 ENOG4105EKQ RNA-directed DNA polymerase FOC74_00535 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC74_00540 ENOG41089BK Glutamine amido-transferase FOC74_00550 ENOG4106J6E FOC74_00585 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOC74_00670 ENOG4105EKQ RNA-directed DNA polymerase FOC74_00740 ENOG4105TQK DNA polymerase iii, delta' subunit FOC74_00750 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC74_00765 ENOG4105EKQ RNA-directed DNA polymerase FOC74_00820 ENOG4105EKQ RNA-directed DNA polymerase FOC74_00890 ENOG4105EKQ RNA-directed DNA polymerase FOC74_00910 ENOG4105K4H Nlp p60 protein FOC74_00945 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC74_01045 ENOG4105D7V transposase FOC74_01190 ENOG41067QW Transcriptional regulator FOC74_01220 ENOG4105C6E dna polymerase iii FOC74_01230 ENOG4105ENA helicase FOC74_01235 ENOG4105FA2 dna polymerase iii FOC74_01255 ENOG4108TF4 von Willebrand factor, type A FOC74_01260 ENOG4105KRN Transcriptional regulator, abrb family FOC74_01330 ENOG4105D6J arsenicaL-resistance protein FOC74_01335 ENOG41082YX Transcriptional regulator, arsr family FOC74_01350 ENOG4105CKI cobalamin synthesis protein FOC74_01355 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOC74_01365 ENOG41067QW Transcriptional regulator FOC74_01370 ENOG4105CJ3 phosphate transporter FOC74_01375 ENOG41085FC arsR family transcriptional regulator FOC74_01455 ENOG4105QBX endodeoxyribonuclease RusA FOC74_01555 ENOG4105CDU Replicative dna helicase FOC74_01575 ENOG4108PNI recT protein FOC74_01580 ENOG4108NF7 phage-type endonuclease FOC74_01640 ENOG4107QJE Chromosome Partitioning Protein FOC74_01680 ENOG4105PKS Excinuclease abc c subunit domain protein FOC74_01695 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC74_01765 ENOG41060SN FOC74_01795 ENOG4106CGH Phage Mu protein F like protein FOC74_01800 ENOG4108MDF Phage Portal Protein FOC74_01825 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC74_01845 ENOG410874W AraC family transcriptional regulator FOC74_01850 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC74_01865 ENOG4108AEY RNA polymerase sigma factor FOC74_01885 ENOG4108JQ1 Dehydrogenase FOC74_01900 ENOG4105DVH amino acid FOC74_01910 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FOC74_01915 ENOG4105C45 hydrogenase expression formation protein (HypE) FOC74_01925 ENOG4108JPW Aminotransferase FOC74_01940 ENOG4105EJQ L-serine dehydratase FOC74_01945 ENOG4105C44 Serine transporter FOC74_01980 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC74_02015 ENOG4105TRI Hydrolase FOC74_02045 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC74_02055 ENOG4106P55 Transcriptional regulator FOC74_02065 ENOG4107QR9 Iron-sulfur cluster binding protein FOC74_02070 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) FOC74_02075 ENOG4105DJB Major Facilitator Superfamily FOC74_02080 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC74_02090 ENOG4105BZU Histidine kinase FOC74_02105 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FOC74_02110 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC74_02125 ENOG4105JQZ Methyltransferase FOC74_02145 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC74_02155 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FOC74_02160 ENOG4108NNI Beta-lactamase domain-containing protein FOC74_02185 ENOG4105K6H D-cysteine desulfhydrase FOC74_02210 ENOG41062D9 Histidine kinase FOC74_02215 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC74_02230 ENOG4105IIP Membrane FOC74_02240 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC74_02245 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOC74_02330 ENOG4108YXU transcriptional regulator AsnC family FOC74_02335 ENOG4105CHR reductase FOC74_02340 ENOG4108IG5 Transcriptional regulator FOC74_02345 ENOG4107P5I polyketide synthase FOC74_02360 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC74_02365 ENOG4105BZU Histidine kinase FOC74_02385 ENOG41085FC arsR family transcriptional regulator FOC74_02390 ENOG4105D6J arsenicaL-resistance protein FOC74_02425 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FOC74_02430 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC74_02445 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FOC74_02450 ENOG4108TWJ NADH dehydrogenase subunit 5 FOC74_02465 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOC74_02470 ENOG4108606 TspO/MBR family FOC74_02505 ENOG41090MY MarR family Transcriptional regulator FOC74_02530 ENOG4105CHJ isochorismatase hydrolase FOC74_02540 ENOG4105CH6 catalase FOC74_02545 ENOG4105CGH 5'-nucleotidase FOC74_02560 ENOG4105CSV Glutaminase FOC74_02580 ENOG4108Q8B Spore germination protein FOC74_02585 ENOG4108NHD germination protein FOC74_02600 ENOG4105II7 pyrroline-5-carboxylate reductase FOC74_02610 ENOG4105CUB amino acid FOC74_02615 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC74_02625 ENOG4108IMY Transcriptional regulator FOC74_02630 ENOG4105HDK L-asparaginase FOC74_02635 ENOG4108IJ0 Aspartate ammonia-lyase FOC74_02645 ENOG4105E2A Dehydrogenase FOC74_02710 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOC74_02740 ENOG4105DWD nucleoside recognition domain protein FOC74_02755 ENOG4105FDT acyl-CoA dehydrogenase FOC74_02765 ENOG4108ZHR arsR family transcriptional regulator FOC74_02770 ENOG4108ZRV stage ii sporulation protein p FOC74_02775 ENOG4106N3A copper homeostasis protein cutc FOC74_02785 ENOG4107258 Transcriptional regulator FOC74_02790 ENOG4105P4J Allophanate hydrolase, subunit 1 FOC74_02825 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FOC74_02835 ENOG4107RF6 penicillin-binding protein FOC74_02865 ENOG4105F1N DNA alkylation repair FOC74_02875 ENOG4108IQI permease FOC74_02880 ENOG4105KNA -acetyltransferase FOC74_02885 ENOG410635A Membrane FOC74_02950 ENOG4108XET gCN5-related N-acetyltransferase FOC74_02980 ENOG4105C19 ABC transporter FOC74_02990 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC74_03020 ENOG4105EFZ amidohydrolase FOC74_03025 ENOG4105D2S major facilitator superfamily FOC74_03030 ENOG4105G9B Transcriptional regulator FOC74_03040 ENOG4105VZJ PTS System FOC74_03055 ENOG4108QVC Component IIC FOC74_03060 ENOG4105VCP PTS System FOC74_03065 ENOG4105CS2 ec 3.2.1.21 FOC74_03070 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC74_03075 ENOG4105E39 Enoyl-CoA hydratase FOC74_03080 ENOG4105CHU acetyl-coa acetyltransferase FOC74_03085 ENOG4105CEY Amp-dependent synthetase and ligase FOC74_03090 ENOG41082UD thioesterase Superfamily protein FOC74_03105 ENOG4105ERH Fumarylacetoacetate hydrolase FOC74_03125 ENOG4105FS7 Transcriptional regulator FOC74_03130 ENOG4108TVJ Nitroreductase FOC74_03175 ENOG4105C8Y Acetylornithine aminotransferase FOC74_03185 ENOG4105CKK Glycosyl transferase, family 2 FOC74_03215 ENOG4105CSH Transporter FOC74_03230 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC74_03255 ENOG41068WN FOC74_03265 ENOG4108WCX response regulator FOC74_03275 ENOG41090T1 Membrane FOC74_03290 ENOG4105VMP Transcriptional regulator FOC74_03300 ENOG4105G6Z alkaline phosphatase FOC74_03305 ENOG4105ECK Fatty Acid Desaturase FOC74_03310 ENOG4105E0Y RtcB Protein FOC74_03320 ENOG4107258 Transcriptional regulator FOC74_03350 ENOG4105II7 pyrroline-5-carboxylate reductase FOC74_03355 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FOC74_03385 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FOC74_03410 ENOG41061GT Aldolase FOC74_03420 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) FOC74_03425 ENOG4105DKT Transcriptional regulator FOC74_03435 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FOC74_03445 ENOG4105D4B ABC, transporter FOC74_03460 ENOG4108JUB Transcriptional regulator FOC74_03465 ENOG4105J5T Amp-dependent synthetase and ligase FOC74_03470 ENOG4105E39 Enoyl-CoA hydratase FOC74_03475 ENOG4105CY2 Citrate transporter FOC74_03485 ENOG41069ER domain protein FOC74_03500 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) FOC74_03520 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC74_03530 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC74_03550 ENOG41082JN Transcriptional regulator FOC74_03555 ENOG4105EYF MMPL domain protein FOC74_03565 ENOG4105C5H ABC transporter FOC74_03570 ENOG4105E0M Sulfatase FOC74_03575 ENOG4108ZCF integral membrane protein FOC74_03595 ENOG4107VC0 DNA alkylation repair enzyme FOC74_03645 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FOC74_03665 ENOG4105E09 nadh pyrophosphatase FOC74_03690 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FOC74_03695 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC74_03700 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOC74_03710 ENOG4105C02 permease FOC74_03760 ENOG4105DVE abc transporter atp-binding protein FOC74_03775 ENOG4108ZMI UPF0477 protein FOC74_03790 ENOG4105CHM Aminotransferase FOC74_03830 ENOG41089UC methyltransferase, type 11 FOC74_03845 ENOG4107BMA Transglycosylase associated protein FOC74_03865 ENOG4106K7D Major facilitator family transporter FOC74_03870 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC74_03910 ENOG4105EPR degv family FOC74_03920 ENOG4105DPN Oligoendopeptidase f FOC74_03955 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC74_03960 ENOG4105BZU Histidine kinase FOC74_03965 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FOC74_04010 ENOG4105DTQ mandelate racemase muconate lactonizing FOC74_04025 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC74_04030 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC74_04045 ENOG4107T5V SNARE associated Golgi FOC74_04075 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FOC74_04085 ENOG41080HI glycine oxidase FOC74_04090 ENOG4105CTU Proline racemase FOC74_04095 ENOG4105CTU Proline racemase FOC74_04100 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC74_04105 ENOG4105C26 Dehydrogenase FOC74_04110 ENOG4105BZG amino acid carrier protein FOC74_04130 ENOG4108M1A Chitin-binding protein FOC74_04175 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC74_04195 ENOG4105EEM helicase FOC74_04215 ENOG4108Z7F N-acetyltransferase FOC74_04245 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC74_04270 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC74_04290 ENOG41087PP glycosyltransferase MGT family FOC74_04295 ENOG4108M1A Chitin-binding protein FOC74_04300 ENOG41082BV acetyltransferase FOC74_04305 ENOG4105E66 phosphoriboisomerase A FOC74_04330 ENOG4108IJ7 Glycine betaine FOC74_04335 ENOG4107SQ8 Glycine betaine FOC74_04375 ENOG4105RHY Pfam:UPF0157 FOC74_04380 ENOG4105E1F short-chain dehydrogenase reductase FOC74_04390 ENOG4107RUY (E1 component), alpha subunit FOC74_04400 ENOG4107QKR Dehydrogenase FOC74_04425 ENOG4105E98 transcriptional regulator DeoR family FOC74_04445 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOC74_04465 ENOG4107Z3H Transcriptional regulator, TetR family FOC74_04500 ENOG4105MSI germination protein ypeb FOC74_04555 ENOG4105FDR Membrane FOC74_04565 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC74_04590 ENOG4108IUM Glycogen debranching enzyme FOC74_04605 ENOG4105DY8 decarboxylase FOC74_04655 ENOG4107VFR oxidoreductase FOC74_04695 ENOG4105PKS Excinuclease abc c subunit domain protein FOC74_04730 ENOG4105KWG Pfam:DUF1696 FOC74_04735 ENOG4108NRW Phospholipase, patatin family FOC74_04755 ENOG4108XI2 Domain of unknown function (DUF1963) FOC74_04790 ENOG4108Z4K mutator MutT protein FOC74_04795 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC74_04800 ENOG4105E09 nadh pyrophosphatase FOC74_04815 ENOG4105FCD Major Facilitator FOC74_04855 ENOG4107Y9U Membrane FOC74_04875 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC74_04890 ENOG4107Y80 Major Facilitator superfamily FOC74_04920 ENOG4108V4B ThiJ pfpI FOC74_04955 ENOG4105FQP Beta-lactamase FOC74_04965 ENOG4105CJN penicillin-binding protein FOC74_04970 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOC74_04975 ENOG4105CB2 alcohol dehydrogenase FOC74_04990 ENOG4108HGU Histidine kinase FOC74_05025 ENOG4107RF6 penicillin-binding protein FOC74_05030 ENOG4105BZU Histidine kinase FOC74_05035 ENOG410667J hydrolase FOC74_05115 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC74_05265 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein FOC74_05355 ENOG4105VTR Integrase FOC74_05390 ENOG4105ETU transcriptional activator (TenA FOC74_05475 ENOG4105DK7 lysyl-tRNA synthetase FOC74_05485 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FOC74_05505 ENOG4105CPQ Dehydrogenase FOC74_05540 ENOG4105CUV Homoserine Kinase FOC74_05560 ENOG4107Y80 Major Facilitator superfamily FOC74_05570 ENOG4105FQP Beta-lactamase FOC74_05620 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC74_05630 ENOG4105T9C HD domain FOC74_05645 ENOG4105DZ1 carboxypeptidase FOC74_05660 ENOG4105DBI uridine monophosphokinase FOC74_05665 ENOG4105WCN acetyltransferase FOC74_05675 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC74_05680 ENOG4107QX3 carboxylase FOC74_05685 ENOG4105E39 Enoyl-CoA hydratase FOC74_05690 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC74_05695 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FOC74_05700 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC74_05705 ENOG4105C1G acyl-Coa dehydrogenase FOC74_05720 ENOG4107Z3H Transcriptional regulator, TetR family FOC74_05730 ENOG4105CJ1 ABC, transporter FOC74_05745 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FOC74_05770 ENOG4105BZU Histidine kinase FOC74_05775 ENOG4105C5H ABC transporter FOC74_05780 ENOG41067SE Tetr family transcriptional regulator FOC74_05785 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity FOC74_05800 ENOG4108VXD carboxy-peptidase FOC74_05815 ENOG4105VZ8 Transcriptional regulator FOC74_05830 ENOG4105CGH 5'-nucleotidase FOC74_05845 ENOG4105DH8 myo-inositol catabolism FOC74_05850 ENOG4105D2N Aldolase FOC74_05875 ENOG4105CK5 oxidoreductase FOC74_05880 ENOG4105IE8 Alpha-ketoglutarate permease FOC74_05885 ENOG4105ETE Transcriptional regulator (LacI family FOC74_05890 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOC74_05900 ENOG4107RF6 penicillin-binding protein FOC74_05905 ENOG4107RF6 penicillin-binding protein FOC74_05930 ENOG4105CIN aminoacyl-histidine dipeptidase FOC74_05965 ENOG41090HR transcriptional regulator FOC74_05970 ENOG4107RA9 decarboxylase FOC74_05985 ENOG41088CC tellurite resistance protein tehB FOC74_06005 ENOG4108RZE Tetr family transcriptional regulator FOC74_06020 ENOG4105C1J atp-dependent rna helicase FOC74_06035 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC74_06070 ENOG4107STF Involved in phosphonate degradation (By similarity) FOC74_06080 ENOG4105RD7 BadF BadG BcrA BcrD FOC74_06105 ENOG4105F32 YngK protein FOC74_06130 ENOG4108KPJ rna polymerase sigma factor FOC74_06135 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B FOC74_06145 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC74_06175 ENOG4108JCI Transcriptional regulator FOC74_06195 ENOG4105BZ1 (ABC) transporter FOC74_06200 ENOG4105BZ1 (ABC) transporter FOC74_06215 ENOG4108RPX mosc domain containing protein FOC74_06220 ENOG4105DND Transcriptional regulator FOC74_06235 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC74_06240 ENOG4107V2S Transcriptional regulator FOC74_06285 ENOG410667J hydrolase FOC74_06305 ENOG4105VEQ Cold shock protein FOC74_06315 ENOG41068WN FOC74_06325 ENOG4105C1Q protoporphyrinogen oxidase FOC74_06355 ENOG4105WCN acetyltransferase FOC74_06380 ENOG4105EYF MMPL domain protein FOC74_06390 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC74_06405 ENOG41081I9 integral membrane protein FOC74_06425 ENOG4108D32 Methyltransferase FOC74_06445 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC74_06455 ENOG4105C19 ABC transporter FOC74_06460 ENOG4105C22 threonyL-tRNA synthetase FOC74_06465 ENOG4105FE9 pseudouridine synthase FOC74_06485 ENOG4105BZG amino acid carrier protein FOC74_06505 ENOG4105K70 DNA-binding protein FOC74_06520 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC74_06525 ENOG4105WQT MbtH domain protein FOC74_06530 ENOG4105CEY Amp-dependent synthetase and ligase FOC74_06535 ENOG4105WQI isochorismatase FOC74_06540 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FOC74_06545 ENOG4105E4F Isochorismate synthase FOC74_06550 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FOC74_06555 ENOG4105FCD Major Facilitator FOC74_06575 ENOG4105EYH Exonuclease FOC74_06580 ENOG4107RFY SbcCD D subunit FOC74_06595 ENOG4105E39 Enoyl-CoA hydratase FOC74_06600 ENOG4105N14 lysine exporter protein LysE YggA FOC74_06610 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC74_06615 ENOG4105C1G acyl-Coa dehydrogenase FOC74_06620 ENOG4105CR4 methylisocitrate lyase FOC74_06625 ENOG4105DXD 2-methylcitrate dehydratase FOC74_06635 ENOG4105W8X HesB YadR YfhF-family protein FOC74_06640 ENOG4105DP8 Major facilitator superfamily MFS_1 FOC74_06645 ENOG4105BZ4 penicillin-binding protein FOC74_06685 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC74_06790 ENOG4108IBT Inherit from COG: transposase FOC74_06805 ENOG4105SZ6 Thioredoxin FOC74_06815 ENOG410841Q phosphoesterase PA-phosphatase related protein FOC74_06820 ENOG4108N23 SpoOM-related protein FOC74_06860 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FOC74_06865 ENOG4108JUB Transcriptional regulator FOC74_06870 ENOG4108TSC N-acetyltransferase FOC74_06875 ENOG4107S4Y M20 DapE family protein YgeY FOC74_06890 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC74_06915 ENOG4105C37 (CBS) domain FOC74_06950 ENOG4105E90 ABC transporter FOC74_06955 ENOG4108IJ8 ABC transporter FOC74_06985 ENOG4105CMG Carbohydrate kinase FOC74_06990 ENOG4105CMG Carbohydrate kinase FOC74_07025 ENOG4105WH1 Two component transcriptional regulator luxr family FOC74_07030 ENOG4105BZU Histidine kinase FOC74_07035 ENOG4105D8X mechanosensitive ion channel FOC74_07040 ENOG4107Y70 Heat shock protein FOC74_07070 ENOG4105F0I Aminotransferase FOC74_07075 ENOG4108MES Periplasmic binding protein FOC74_07090 ENOG4105CAQ asparagine synthetase FOC74_07095 ENOG4107Y70 Heat shock protein FOC74_07100 ENOG4108KF3 Electron transport protein SCO1 SenC FOC74_07105 ENOG4105E8R UPF0173 metal-dependent hydrolase FOC74_07110 ENOG4108RCR degv family FOC74_07120 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOC74_07130 ENOG4108UT2 hemolysin iii FOC74_07135 ENOG4105E9Q Acyl-transferase FOC74_07145 ENOG4107RVG penicillin-binding protein FOC74_07160 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FOC74_07180 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FOC74_07205 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FOC74_07210 ENOG4105KD7 acetyltransferase FOC74_07230 ENOG4105CY2 Citrate transporter FOC74_07235 ENOG4107XGZ Hydrolase FOC74_07255 ENOG4105C8J )-transporter FOC74_07270 ENOG41062D9 Histidine kinase FOC74_07275 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC74_07280 ENOG4107QPK )-transporter FOC74_07285 ENOG4105BZW Glycerate kinase FOC74_07330 ENOG4105EC2 ftsk spoIIIe FOC74_07350 ENOG4105C5S asparaginyl-tRNA synthetase FOC74_07370 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FOC74_07390 ENOG4105C75 arginyL-tRNA synthetase FOC74_07400 ENOG4105EKQ RNA-directed DNA polymerase FOC74_07425 ENOG4105EKQ RNA-directed DNA polymerase FOC74_07430 ENOG4108UUM single-stranded DNA-binding protein FOC74_07445 ENOG4105C5H ABC transporter FOC74_07475 ENOG4105MCT stage V sporulation protein S FOC74_07510 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FOC74_07515 ENOG4108IFG nitrite reductase, (NAD(P)H) FOC74_07520 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOC74_07525 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC74_07530 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC74_07535 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC74_07555 ENOG4108ZAF Molybdopterin FOC74_07560 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC74_07565 ENOG4105D06 uba thif-type nad fad binding protein FOC74_07570 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC74_07575 ENOG4107V6Q Cyclic nucleotide-binding domain FOC74_07585 ENOG4105D3W isochorismatase FOC74_07590 ENOG4108X3M OsmC Ohr family protein FOC74_07595 ENOG4106HZJ FOC74_07600 ENOG4107QN2 dihydrolipoyl dehydrogenase FOC74_07605 ENOG4105K63 Thioredoxin FOC74_07610 ENOG4108Z40 Transcriptional regulator FOC74_07625 ENOG4105R3A Nitrate reductase FOC74_07630 ENOG4108IUE nitrate reductase beta subunit FOC74_07640 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC74_07655 ENOG4108V06 Glutathione peroxidase FOC74_07675 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) FOC74_07690 ENOG4105EMN RNA polymerase sigma factor FOC74_07695 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FOC74_07705 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FOC74_07730 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC74_07755 ENOG4105KBJ sporulation protein ytfj FOC74_07765 ENOG4105EKQ RNA-directed DNA polymerase FOC74_07825 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC74_07855 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC74_07860 ENOG4108JYZ YitT family FOC74_07865 ENOG41087PP glycosyltransferase MGT family FOC74_07885 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC74_07895 ENOG4108X4Q Hydrolase FOC74_07920 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC74_07930 ENOG4108VXD carboxy-peptidase FOC74_07940 ENOG4108ZRV stage ii sporulation protein p FOC74_07960 ENOG4108Z7R Chaperone CsaA FOC74_07980 ENOG4105C37 (CBS) domain FOC74_07985 ENOG4105SXS Protein of unknown function (DUF456) FOC74_08005 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC74_08015 ENOG4108S4H thioesterase Superfamily protein FOC74_08025 ENOG4108PJD permease FOC74_08040 ENOG4107T5V SNARE associated Golgi FOC74_08060 ENOG4107TB6 phosphoglycerate mutase FOC74_08085 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC74_08095 ENOG4105K4T epimerase FOC74_08105 ENOG4105DSE periplasmic solute binding protein FOC74_08165 ENOG4105CKI cobalamin synthesis protein FOC74_08170 ENOG4107QM2 Aldo Keto reductase FOC74_08190 ENOG4105DEN Luciferase family FOC74_08205 ENOG4108WPJ Ferritin-like domain FOC74_08210 ENOG4108K88 Membrane FOC74_08225 ENOG4105C8Q Methyl-accepting chemotaxis FOC74_08250 ENOG4107XZQ multidrug resistance protein FOC74_08255 ENOG4107SET aldo keto reductase FOC74_08260 ENOG4105YVS arsR family transcriptional regulator FOC74_08270 ENOG4105KRN Transcriptional regulator, abrb family FOC74_08320 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FOC74_08330 ENOG4105YWU small acid-soluble spore protein FOC74_08335 ENOG4108WBH protein TIM barrel FOC74_08350 ENOG4105CEY Amp-dependent synthetase and ligase FOC74_08355 ENOG4105DUU IucA IucC family protein FOC74_08365 ENOG4105VRR gCN5-related N-acetyltransferase FOC74_08370 ENOG4105KT7 mgtC SapB transporter FOC74_08385 ENOG4105BZU Histidine kinase FOC74_08390 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC74_08400 ENOG4108KGH TRANSCRIPTIONal FOC74_08425 ENOG4105D6E homoserine dehydrogenase FOC74_08440 ENOG4106AKJ FOC74_08450 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FOC74_08470 ENOG4105BZU Histidine kinase FOC74_08475 ENOG4105EFI regulatoR FOC74_08480 ENOG4105BZ1 (ABC) transporter FOC74_08525 ENOG4108JJ8 (ABC) transporter FOC74_08530 ENOG4108JJ9 ABC, transporter FOC74_08535 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC74_08540 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC74_08570 ENOG4105SKE transcriptional Regulator LysR family FOC74_08580 ENOG4105C32 Amino acid ABC transporter (Permease) FOC74_08585 ENOG4108IV0 ABC, transporter FOC74_08590 ENOG4105C0Z ABC transporter FOC74_08600 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC74_08605 ENOG4108Z7G MaoC domain protein dehydratase FOC74_08625 ENOG4105CKI cobalamin synthesis protein FOC74_08640 ENOG4106F5Q Membrane FOC74_08645 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC74_08655 ENOG4108TVJ Nitroreductase FOC74_08660 ENOG4107ZXU DSBA oxidoreductase FOC74_08665 ENOG4108Z40 Transcriptional regulator FOC74_08670 ENOG4105GZI Transcriptional regulator FOC74_08675 ENOG4107RT3 EamA-like transporter family FOC74_08680 ENOG4105KTB nuclear export factor GLE1 FOC74_08685 ENOG4108T5E Copper resistance protein FOC74_08730 ENOG4107R16 Multicopper oxidase FOC74_08735 ENOG4107RAQ aminopeptidase FOC74_08770 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FOC74_08775 ENOG4105D9N nucleoside FOC74_08785 ENOG4107RHR regulatoR FOC74_08810 ENOG4105C0X amino acid FOC74_08815 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOC74_08830 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOC74_08850 ENOG41068WN FOC74_08900 ENOG4105CYC Transferase FOC74_08905 ENOG4105DY9 regulatoR FOC74_08915 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FOC74_08920 ENOG4105C6X Major Facilitator FOC74_08945 ENOG4105C7B Threonine dehydratase FOC74_08955 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC74_08960 ENOG4108ZP8 Acetolactate synthase small subunit FOC74_08965 ENOG4105C7K acetolactate synthase FOC74_08970 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC74_08975 ENOG4105CHR reductase FOC74_08980 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC74_08995 ENOG4105H67 Protein of unknown function (DUF421) FOC74_09000 ENOG4105X5K response regulator receiver protein FOC74_09010 ENOG4105C8J )-transporter FOC74_09030 ENOG4105C6T cysteine synthase FOC74_09035 ENOG4105EU0 Major facilitator Superfamily FOC74_09045 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC74_09060 ENOG4105DXI Major Facilitator superfamily FOC74_09065 ENOG4105CSR polyphosphate kinase 2 FOC74_09105 ENOG4105FVX FOC74_09170 ENOG4105C6K Malic enzyme FOC74_09175 ENOG4108IJ0 Aspartate ammonia-lyase FOC74_09185 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC74_09205 ENOG4105CJ1 ABC, transporter FOC74_09240 ENOG4106BRA Membrane FOC74_09270 ENOG4107QIV Cytochrome c biogenesis protein FOC74_09290 ENOG4105EC3 peptidase S51, dipeptidase E FOC74_09295 ENOG4107QJQ Mate efflux family protein FOC74_09315 ENOG4105C9Q fumarate hydratase class II FOC74_09325 ENOG4105VUF Transcriptional regulator FOC74_09330 ENOG4105DFD Na H antiporter FOC74_09345 ENOG4108PJD permease FOC74_09350 ENOG4105CKI cobalamin synthesis protein FOC74_09355 ENOG4108UZ3 Transporter FOC74_09360 ENOG4105DRR Transcriptional regulator, GntR family FOC74_09370 ENOG4105PGM cation diffusion facilitator family transporter FOC74_09390 ENOG4105CAQ asparagine synthetase FOC74_09400 ENOG4105K56 Transcriptional regulator FOC74_09420 ENOG4105CVJ phosphoglycerate mutase FOC74_09460 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOC74_09465 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FOC74_09475 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC74_09505 ENOG4105KAC Antibiotic biosynthesis monooxygenase FOC74_09540 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC74_09545 ENOG4105KTQ flagellar basal-body rod protein FOC74_09550 ENOG4105FZW flagellar biosynthesis regulator FlhF FOC74_09555 ENOG4105D7B Flagellar biosynthesis protein flha FOC74_09560 ENOG4105D00 flagellar biosynthetic protein flhB FOC74_09570 ENOG4105VS8 Flagellar biosynthetic protein fliq FOC74_09575 ENOG4105CN7 Flagellar biosynthetic protein FliP FOC74_09585 ENOG4105DD5 Flagellar motor switch protein FOC74_09590 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC74_09600 ENOG4105E4C Lytic transglycosylase catalytic FOC74_09605 ENOG4105I03 Flagellin FOC74_09610 ENOG4105I03 Flagellin FOC74_09620 ENOG4107R88 Chemotaxis protein (CheV) FOC74_09635 ENOG4105BZE flagellar hook protein, FlgE FOC74_09665 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC74_09670 ENOG4107U2N Flagellar M-ring protein FOC74_09680 ENOG4108ZC9 flagellar basal-body rod protein flgc FOC74_09685 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOC74_09700 ENOG4107TPX flagellar hook-associated FOC74_09705 ENOG4105DTJ flagellar hook-associated protein FOC74_09710 ENOG4105E1Q flagellar hook-associated protein FOC74_09730 ENOG4105BZU Histidine kinase FOC74_09745 ENOG4105DD5 Flagellar motor switch protein FOC74_09750 ENOG4105CBS Chea signal transduction histidine kinase FOC74_09755 ENOG4107YTP response regulator receiver protein FOC74_09760 ENOG4105ER2 Ompa motb domain protein FOC74_09765 ENOG4107R0U MotA TolQ exbB proton channel FOC74_09775 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC74_09830 ENOG41080C8 DUF218 domain FOC74_09835 ENOG4105H67 Protein of unknown function (DUF421) FOC74_09845 ENOG4108Z5V transcriptional regulator, merr family FOC74_09850 ENOG4105CN5 Metallo-Beta-Lactamase FOC74_09855 ENOG4107RWR Sodium hydrogen exchanger FOC74_09865 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC74_09930 ENOG41081VK Ribonuclease FOC74_09950 ENOG4108SZE gCN5-related N-acetyltransferase FOC74_09965 ENOG4105CPK Glycosyl transferase (Group 1 FOC74_10025 ENOG4106032 Glutathionylspermidine synthase FOC74_10050 ENOG4105KHC sulfurtransferase FOC74_10060 ENOG4108W0I acetyltransferase FOC74_10070 ENOG410890F Dynamin family FOC74_10075 ENOG4105DHF Membrane FOC74_10080 ENOG4105C2W permease FOC74_10090 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC74_10105 ENOG4105CTD carboxy-peptidase FOC74_10110 ENOG4105DVT helicase FOC74_10120 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOC74_10180 ENOG4105BZ4 penicillin-binding protein FOC74_10190 ENOG4105CSM endonuclease III FOC74_10210 ENOG4105YAC FOC74_10215 ENOG4105DVT helicase FOC74_10250 ENOG4105CPK Glycosyl transferase (Group 1 FOC74_10255 ENOG4105FJR Lmbe family FOC74_10270 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FOC74_10275 ENOG4108JYZ YitT family FOC74_10305 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit FOC74_10310 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOC74_10315 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FOC74_10330 ENOG41068YB TPR repeat-containing protein FOC74_10335 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC74_10355 ENOG4105EAH synthase FOC74_10365 ENOG4105XXQ heptaprenyl diphosphate synthase component I FOC74_10380 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FOC74_10410 ENOG41065D1 FOC74_10415 ENOG4105S2F FOC74_10450 ENOG4105HDK L-asparaginase FOC74_10455 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FOC74_10480 ENOG4108S6Z Negative regulator of genetic competence FOC74_10485 ENOG4107X2D transcriptional regulator, merr family FOC74_10490 ENOG4107RGJ metallophosphoesterase FOC74_10500 ENOG4105I7S Abortive infection protein FOC74_10505 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC74_10520 ENOG4108SAX Membrane FOC74_10530 ENOG41063SB peptidase FOC74_10535 ENOG4108WBT adenosyltransferase FOC74_10540 ENOG4105BZU Histidine kinase FOC74_10545 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC74_10550 ENOG4105CRE cytochrome C FOC74_10555 ENOG4107TWT Cytochrome c biogenesis protein FOC74_10565 ENOG4105FE9 pseudouridine synthase FOC74_10575 ENOG4108JIC nucleoside recognition domain protein FOC74_10580 ENOG4105DZ1 carboxypeptidase FOC74_10585 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC74_10620 ENOG4105BZU Histidine kinase FOC74_10635 ENOG4105I3N Conserved Protein FOC74_10640 ENOG4105BZU Histidine kinase FOC74_10655 ENOG4105BZ4 penicillin-binding protein FOC74_10660 ENOG4107GRR phosphate transport regulator FOC74_10665 ENOG4105CJ3 phosphate transporter FOC74_10710 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOC74_10730 ENOG4105WH1 Two component transcriptional regulator luxr family FOC74_10735 ENOG4105ENE Histidine kinase FOC74_10755 ENOG4105DFD Na H antiporter FOC74_10775 ENOG4105C8J )-transporter FOC74_10780 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC74_10785 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC74_10790 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC74_10800 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FOC74_10805 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FOC74_10825 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOC74_10835 ENOG4105E0M Sulfatase FOC74_10840 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC74_10855 ENOG4107RVV histidinol phosphate phosphatase, hisj family FOC74_10930 ENOG4108ZP8 Acetolactate synthase small subunit FOC74_10935 ENOG4105C7K acetolactate synthase FOC74_10940 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC74_10960 ENOG4105KBJ sporulation protein ytfj FOC74_10965 ENOG41063Y9 FOC74_10970 ENOG4105CZN Potassium uptake protein FOC74_11000 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC74_11005 ENOG4107QMU Mate efflux family protein FOC74_11040 ENOG4105NQC Flavodoxin FOC74_11065 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC74_11075 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC74_11080 ENOG4105EA8 2-Nitropropane dioxygenase FOC74_11085 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC74_11125 ENOG4105CJ1 ABC, transporter FOC74_11135 ENOG4105CZV ABC transporter FOC74_11140 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC74_11145 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC74_11165 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOC74_11205 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOC74_11210 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FOC74_11220 ENOG4105BZU Histidine kinase FOC74_11225 ENOG4106DF1 FOC74_11235 ENOG41090MY MarR family Transcriptional regulator FOC74_11240 ENOG4105BZU Histidine kinase FOC74_11250 ENOG4105PXI polysaccharide deacetylase FOC74_11260 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FOC74_11270 ENOG4105E98 transcriptional regulator DeoR family FOC74_11290 ENOG4107RCV ABC transporter, permease FOC74_11295 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC74_11300 ENOG4105C4Y ABC transporter FOC74_11320 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC74_11330 ENOG4105CHR reductase FOC74_11350 ENOG4108Z7G MaoC domain protein dehydratase FOC74_11355 ENOG410681C small acid-soluble spore protein FOC74_11360 ENOG4105CZN Potassium uptake protein FOC74_11365 ENOG4107TS3 membrane protein, TerC FOC74_11370 ENOG4108QTI )-transporter FOC74_11380 ENOG4106A3R peptidase FOC74_11400 ENOG4105JXH GntR family transcriptional regulator FOC74_11405 ENOG4105BZU Histidine kinase FOC74_11410 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC74_11425 ENOG4105CQB FAD linked oxidase domain protein FOC74_11430 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOC74_11435 ENOG4105K4I Scp-like extracellular FOC74_11445 ENOG4108YBP pseudouridine synthase FOC74_11455 ENOG4105EYF MMPL domain protein FOC74_11465 ENOG4107RUE extracellular solute-binding protein family 1 FOC74_11470 ENOG4105D38 putrescine abc transporter FOC74_11475 ENOG4105F38 ABC transporter, permease FOC74_11485 ENOG4105C26 Dehydrogenase FOC74_11520 ENOG4105VFR signal peptidase FOC74_11525 ENOG4105DZ1 carboxypeptidase FOC74_11535 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FOC74_11550 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC74_11570 ENOG4105EFC phage portal protein HK97 family FOC74_11605 ENOG4108NE4 FOC74_11705 ENOG4105VZ8 Transcriptional regulator FOC74_11715 ENOG4105C7S Dehydrogenase FOC74_11820 ENOG4105DDQ anthranilate synthase FOC74_11830 ENOG4105CK7 Sodium proline symporter FOC74_11905 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOC74_11915 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC74_11920 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOC74_11940 ENOG4107TVC Glycosyl transferase, family 2 FOC74_11960 ENOG4105K64 Glycosyl transferase, family 2 FOC74_11980 ENOG4105EMS pseudouridine synthase FOC74_11985 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FOC74_12000 ENOG4105MIX Adenylate cyclase FOC74_12005 ENOG4108Z18 K06886 hemoglobin FOC74_12020 ENOG4105DPN Oligoendopeptidase f FOC74_12030 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC74_12040 ENOG4108ZCF integral membrane protein FOC74_12060 ENOG4105UQX Mate efflux family protein FOC74_12065 ENOG4108JQ7 (ABC) transporter FOC74_12075 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC74_12080 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC74_12095 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC74_12110 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC74_12115 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC74_12140 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC74_12150 ENOG4108KP7 hydrolase FOC74_12160 ENOG41073B9 FOC74_12165 ENOG4107AYK membrAne FOC74_12175 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC74_12185 ENOG4105QNR S1 RNA binding domain protein FOC74_12205 ENOG4105BZU Histidine kinase FOC74_12210 ENOG4105CH6 catalase FOC74_12215 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC74_12220 ENOG4105CAQ asparagine synthetase FOC74_12245 ENOG4105ERH Fumarylacetoacetate hydrolase FOC74_12310 ENOG4105XVF Competence transcription factor FOC74_12340 ENOG4107QP3 malate synthase g FOC74_12365 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FOC74_12390 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC74_12410 ENOG41086D8 Transcriptional regulator FOC74_12415 ENOG4108AEY RNA polymerase sigma factor FOC74_12425 ENOG4107TVP HD domain protein FOC74_12435 ENOG4107RN3 metallophosphoesterase FOC74_12475 ENOG4105CNA YD repeat protein FOC74_12490 ENOG4105CNA YD repeat protein FOC74_12535 ENOG4105CEY Amp-dependent synthetase and ligase FOC74_12545 ENOG4105DF9 Lipoate-protein, ligase FOC74_12550 ENOG4108RQ5 Beta-lactamase domain-containing protein FOC74_12555 ENOG4106AXD FOC74_12565 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC74_12575 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) FOC74_12595 ENOG4105ECB domain protein FOC74_12630 ENOG4105C1Q protoporphyrinogen oxidase FOC74_12645 ENOG4105BZ4 penicillin-binding protein FOC74_12650 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FOC74_12655 ENOG4105CKV Membrane FOC74_12660 ENOG410905X membrane-flanked domain protein FOC74_12700 ENOG4105CKV Membrane FOC74_12705 ENOG410905X membrane-flanked domain protein FOC74_12780 ENOG4105K59 histidine triad (HIT) protein FOC74_12805 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC74_12810 ENOG4105EEM helicase FOC74_12820 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC74_12825 ENOG4105C57 major facilitator superfamily FOC74_12840 ENOG4105CNI cell division protein FtsW FOC74_12850 ENOG4105EMN RNA polymerase sigma factor FOC74_12865 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOC74_12880 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC74_12900 ENOG4108MUZ hydrolase FOC74_12955 ENOG4106D4I domain protein FOC74_12960 ENOG4107VRP DNA repair exonuclease FOC74_13020 ENOG4105BZU Histidine kinase FOC74_13025 ENOG4105BZU Histidine kinase FOC74_13030 ENOG4108MJI response regulator FOC74_13040 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC74_13050 ENOG4105WN5 stage II sporulation protein FOC74_13115 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOC74_13130 ENOG4105CMT Dihydroxyacetone kinase FOC74_13140 ENOG4105CMT Dihydroxyacetone kinase FOC74_13170 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC74_13245 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC74_13265 ENOG4105CDU Replicative dna helicase FOC74_13325 ENOG4105M6F mutator MutT protein FOC74_13335 ENOG4108MRH transcriptional regulatory protein FOC74_13345 ENOG4105CSH Transporter FOC74_13360 ENOG4108JQ7 (ABC) transporter FOC74_13370 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC74_13415 ENOG4105CTU Proline racemase FOC74_13435 ENOG4105DER m42 family FOC74_13455 ENOG4105CGU Enoyl-CoA hydratase FOC74_13470 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC74_13475 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC74_13525 ENOG4105CHH sulfate transporter FOC74_13540 ENOG4105D4P Coproporphyrinogen iii oxidase FOC74_13545 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC74_13565 ENOG4107FQX Alpha-acetolactate decarboxylase FOC74_13600 ENOG410839P FOC74_13615 ENOG4105CDA abc transporter atp-binding protein FOC74_13620 ENOG4105DRP amino acid AbC transporter FOC74_13630 ENOG4105BZ1 (ABC) transporter FOC74_13635 ENOG4105BZ1 (ABC) transporter FOC74_13640 ENOG4105C26 Dehydrogenase FOC74_13650 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOC74_13655 ENOG4105D5Q Arginine ornithine antiporter FOC74_13665 ENOG4105CH6 catalase FOC74_13670 ENOG4107RKG DJ-1/PfpI family FOC74_13680 ENOG4105E5W Transporter FOC74_13685 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC74_13695 ENOG4105NF4 modulator of drug activity FOC74_13720 ENOG4105KPY Small multidrug resistance protein FOC74_13735 ENOG4108YXU transcriptional regulator AsnC family FOC74_13775 ENOG4106KNT transcriptional regulator FOC74_13785 ENOG4107RWR Sodium hydrogen exchanger FOC74_13790 ENOG4105CUB amino acid FOC74_13825 ENOG4107T5V SNARE associated Golgi FOC74_13860 ENOG4105WEF catalase FOC74_13890 ENOG4105C19 ABC transporter FOC74_13895 ENOG4107RBB ABC transporter, permease FOC74_13900 ENOG41069ER domain protein FOC74_13920 ENOG4105VZJ PTS System FOC74_13925 ENOG4105VCP PTS System FOC74_13930 ENOG4105EMD TRANSCRIPTIONal FOC74_13955 ENOG4108KGH TRANSCRIPTIONal FOC74_13965 ENOG41087NI Sulfite exporter TauE/SafE FOC74_13970 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FOC74_13980 ENOG41085GJ domain protein FOC74_13985 ENOG4105VFE sira family FOC74_13990 ENOG4107TPS domain protein FOC74_13995 ENOG4105VFE sira family FOC74_14000 ENOG4105XTG Pfam:DUF156 FOC74_14005 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FOC74_14015 ENOG4108TCS Glutamyl endopeptidase FOC74_14025 ENOG4105ED1 spovr family FOC74_14030 ENOG4107Y03 Nitroreductase FOC74_14050 ENOG4108B31 Spore germination protein FOC74_14085 ENOG4108PXI ErfK YbiS YcfS YnhG FOC74_14095 ENOG4105C7N Xanthine uracil vitamin C permease FOC74_14110 ENOG4108INS Transcriptional regulator FOC74_14160 ENOG4105DWF phosphomethylpyrimidine kinase FOC74_14165 ENOG4105D06 uba thif-type nad fad binding protein FOC74_14180 ENOG41080HI glycine oxidase FOC74_14185 ENOG4108VEU Thiamine monophosphate synthase FOC74_14195 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC74_14205 ENOG4105ETU transcriptional activator (TenA FOC74_14225 ENOG41080XQ Signal transduction protein with cbs domains FOC74_14350 ENOG4105E2Z phosphate ABC transporter (Permease FOC74_14355 ENOG4105C8U phosphate abc transporter FOC74_14360 ENOG4105CVA phosphate FOC74_14365 ENOG4105CE1 Ferrous iron transport protein b FOC74_14370 ENOG4105CE1 Ferrous iron transport protein b FOC74_14375 ENOG4105CE1 Ferrous iron transport protein b FOC74_14380 ENOG4108NHD germination protein FOC74_14395 ENOG4105E1V na solute symporter FOC74_14400 ENOG4106CAD Protein of unknown function (DUF3311) FOC74_14415 ENOG4108IQI permease FOC74_14420 ENOG4105E2S oxidase) subunit II FOC74_14425 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC74_14450 ENOG4105MA6 gCN5-related N-acetyltransferase FOC74_14465 ENOG4105C7N Xanthine uracil vitamin C permease FOC74_14470 ENOG4105C85 amino acid FOC74_14490 ENOG4105DUX Transporter FOC74_14500 ENOG4107D63 FOC74_14505 ENOG4105VZ8 Transcriptional regulator FOC74_14510 ENOG41069ER domain protein FOC74_14515 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC74_14580 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOC74_14585 ENOG4105CNN ABC, transporter FOC74_14600 ENOG4108RVA ribokinase FOC74_14605 ENOG4105ETE Transcriptional regulator (LacI family FOC74_14610 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC74_14615 ENOG41067TZ transcriptional regulator, MarR family FOC74_14620 ENOG4105CXY transporter FOC74_14630 ENOG4108JQ7 (ABC) transporter FOC74_14635 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC74_14645 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC74_14655 ENOG41068KF Universal stress protein FOC74_14660 ENOG4105CHH sulfate transporter FOC74_14670 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC74_14675 ENOG4105BZU Histidine kinase FOC74_14680 ENOG4105NAE bifunctional deaminase-reductase domain protein FOC74_14685 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC74_14695 ENOG4105GFR rna polymerase sigma factor FOC74_14710 ENOG4108IQI permease FOC74_14715 ENOG4105DRP amino acid AbC transporter FOC74_14720 ENOG4105EAD ABC transporter FOC74_14725 ENOG4105CT1 (ABC) transporter FOC74_14730 ENOG4105CDA abc transporter atp-binding protein FOC74_14735 ENOG4105BZG amino acid carrier protein FOC74_14740 ENOG4105CRN Aminoglycoside phosphotransferase FOC74_14750 ENOG4105E1K spore germination protein FOC74_14765 ENOG4105CG3 alpha amylase, catalytic region FOC74_14770 ENOG4105C5Y PTS System FOC74_14775 ENOG4107414 GntR family transcriptional regulator FOC74_14780 ENOG4105D5Q Arginine ornithine antiporter FOC74_14785 ENOG4105BZU Histidine kinase FOC74_14800 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC74_14805 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FOC74_14810 ENOG4107T89 von Willebrand factor, type A FOC74_14820 ENOG4105EXW epimerase dehydratase FOC74_14835 ENOG4105E0A ABC, transporter FOC74_14840 ENOG4108IHU transport system permease protein FOC74_14845 ENOG4105DQ5 transport system permease protein FOC74_14850 ENOG4108MES Periplasmic binding protein FOC74_14855 ENOG4105DUX Transporter FOC74_14870 ENOG4105DAA L-lactate FOC74_14875 ENOG4108IJ0 Aspartate ammonia-lyase FOC74_14880 ENOG4105C37 (CBS) domain FOC74_14885 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOC74_14890 ENOG4105D9N nucleoside FOC74_14895 ENOG4108KGH TRANSCRIPTIONal FOC74_14900 ENOG41073R8 VanW family FOC74_14935 ENOG4105DAP Nicotinate phosphoribosyltransferase FOC74_14940 ENOG4105C59 p-type ATPase FOC74_14950 ENOG4105CUB amino acid FOC74_14970 ENOG4108JB9 formate dehydrogenase FOC74_14975 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC74_14980 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC74_14985 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC74_14990 ENOG4105BZU Histidine kinase FOC74_15000 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC74_15005 ENOG4108UZ3 Transporter FOC74_15015 ENOG4105C6K Malic enzyme FOC74_15025 ENOG4108MRH transcriptional regulatory protein FOC74_15050 ENOG4105US7 Histidine kinase FOC74_15055 ENOG4108STX response regulator FOC74_15060 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOC74_15065 ENOG4105BZ7 extracellular solute-binding protein family 1 FOC74_15070 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FOC74_15075 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOC74_15080 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC74_15085 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC74_15105 ENOG4105D4T Citrate transporter FOC74_15110 ENOG4108V9W transcriptional regulatory protein FOC74_15115 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOC74_15125 ENOG4105DZ6 Band 7 protein FOC74_15140 ENOG4105C94 Transporter FOC74_15170 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FOC74_15270 ENOG4105CAR Terminase, large subunit FOC74_15300 ENOG410682Q Phage transcriptional regulator, ArpU FOC74_15345 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FOC74_15370 ENOG4105CDU Replicative dna helicase FOC74_15405 ENOG4108IMY Transcriptional regulator FOC74_15435 ENOG4105CYN Serine protein kinase FOC74_15440 ENOG4105BZU Histidine kinase FOC74_15445 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOC74_15455 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOC74_15465 ENOG4107ZQN disulfide bond FOC74_15470 ENOG4108JQC penicillin-binding protein 1A FOC74_15585 ENOG4105G5W regulator Fur family FOC74_15590 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC74_15610 ENOG4108IUW ABC transporter FOC74_15620 ENOG4105CBC glutamate synthase FOC74_15625 ENOG4107NBY Membrane FOC74_15630 ENOG4105BZ1 (ABC) transporter FOC74_15650 ENOG4106BXE FOC74_15655 ENOG4105CEN a g-specific adenine glycosylase FOC74_15660 ENOG41067AE Membrane-bound metal-dependent hydrolase FOC74_15690 ENOG4105ECP epimerase FOC74_15695 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC74_15715 ENOG4105F1A Pyruvate formate-lyase FOC74_15735 ENOG4105C3I Nad-dependent epimerase dehydratase FOC74_15740 ENOG4107QQG Dehydrogenase FOC74_15745 ENOG4105CKK Glycosyl transferase, family 2 FOC74_15760 ENOG4108A04 Beta-lactamase FOC74_15810 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC74_15845 ENOG4105UPD Calcium Proton FOC74_15850 ENOG410606W general stress protein FOC74_15865 ENOG4107ZTW SNARE associated Golgi FOC74_15890 ENOG4108IPJ Membrane FOC74_15895 ENOG4105C59 p-type ATPase FOC74_15900 ENOG4107U9T Pfam:Ribonuclease_BN FOC74_15910 ENOG4105KJF protein tyrosine phosphatase FOC74_15930 ENOG4108TTB tellurium resistance protein FOC74_15935 ENOG4107TS3 membrane protein, TerC FOC74_15940 ENOG4106FN3 tellurium resistance protein FOC74_15945 ENOG4106FN3 tellurium resistance protein FOC74_15950 ENOG4108N0M stress protein FOC74_15980 ENOG4105DEU major facilitator superfamily FOC74_16000 ENOG41062JF Transcriptional regulator FOC74_16030 ENOG4105C5H ABC transporter FOC74_16045 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC74_16060 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FOC74_16090 ENOG4105CI1 PTS System FOC74_16110 ENOG4105C5B carbamate kinase FOC74_16135 ENOG4105C8Q Methyl-accepting chemotaxis FOC74_16145 ENOG4105EAB amino acid AbC transporter FOC74_16150 ENOG4105E5Q amino acid AbC transporter FOC74_16165 ENOG4105D2S major facilitator superfamily FOC74_16170 ENOG410756H nucleotidyltransferase FOC74_16190 ENOG4105BZU Histidine kinase FOC74_16215 ENOG4106UIA FOC74_16220 ENOG4106UIA FOC74_16240 ENOG4108V5C ABC transporter FOC74_16245 ENOG4105DQ5 transport system permease protein FOC74_16250 ENOG4105EHG Permease protein FOC74_16270 ENOG4105D3R alkyl hydroperoxide reductase FOC74_16290 ENOG4105DFD Na H antiporter FOC74_16300 ENOG4105DTQ mandelate racemase muconate lactonizing FOC74_16315 ENOG4108W15 Protein of unknown function (DUF1456) FOC74_16330 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC74_16335 ENOG4105D9N nucleoside FOC74_16355 ENOG4105KPY Small multidrug resistance protein FOC74_16360 ENOG4105C26 Dehydrogenase FOC74_16370 ENOG4108JPW Aminotransferase FOC74_16375 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC74_16380 ENOG4105CBD Diacylglycerol kinase FOC74_16400 ENOG4107I77 yiaA/B two helix domain FOC74_16405 ENOG410834F Transcriptional regulator FOC74_16425 ENOG4105D01 (LipO)protein FOC74_16430 ENOG4108UMI ABC transporter, permease FOC74_16435 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC74_16440 ENOG4108W2Y isochorismatase FOC74_16470 ENOG4105C4R Atp-dependent dna helicase FOC74_16495 ENOG4105C12 Phosphoribosylglycinamide synthetase FOC74_16505 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOC74_16530 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FOC74_16540 ENOG4105C83 adenylosuccinate lyase FOC74_16545 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOC74_16550 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOC74_16575 ENOG4105SX7 Transporter FOC74_16595 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC74_16640 ENOG4107ZXU DSBA oxidoreductase FOC74_16665 ENOG4105BZU Histidine kinase FOC74_16675 ENOG4105C7N Xanthine uracil vitamin C permease FOC74_16695 ENOG4108TYN CAAX amino terminal protease family protein FOC74_16710 ENOG4105C5H ABC transporter FOC74_16720 ENOG410801F ribosomal-protein-alanine acetyltransferase FOC74_16725 ENOG41072GX Peptidase M22 Glycoprotease FOC74_16730 ENOG4105K8N protein family UPF0079, ATPase FOC74_16830 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FOC74_16840 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC74_16845 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FOC74_16855 ENOG4107ZXI Rhomboid family FOC74_16870 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOC74_16875 ENOG4105CPF Cell wall formation (By similarity) FOC74_16880 ENOG4108SC4 )-transporter FOC74_16890 ENOG4105ERH Fumarylacetoacetate hydrolase FOC74_16895 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FOC74_16925 ENOG410667J hydrolase FOC74_16930 ENOG4108JQ7 (ABC) transporter FOC74_16935 ENOG4105C3U ABC transporter FOC74_16940 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC74_16950 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC74_16965 ENOG4108KYE ABC-2 type transporter FOC74_16970 ENOG41090VJ ABC-2 type transporter FOC74_16975 ENOG4105CJ1 ABC, transporter FOC74_16980 ENOG4105WH1 Two component transcriptional regulator luxr family FOC74_16985 ENOG4105BZU Histidine kinase FOC74_16990 ENOG4105C5H ABC transporter FOC74_17015 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FOC74_17020 ENOG4108RE7 deoxyribonuclease FOC74_17030 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC74_17050 ENOG4105F6E Acyl-transferase FOC74_17080 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FOC74_17085 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC74_17090 ENOG4105E0C molybdate abc transporter FOC74_17100 ENOG4107XDY Nicotinamide Mononucleotide Transporter FOC74_17105 ENOG4105II7 pyrroline-5-carboxylate reductase FOC74_17115 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC74_17120 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC74_17130 ENOG4105U5Y Transcriptional regulator FOC74_17155 ENOG4108JQ7 (ABC) transporter FOC74_17160 ENOG4105C3U ABC transporter FOC74_17165 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC74_17170 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC74_17185 ENOG4105C2C drug resistance transporter, Bcr CflA FOC74_17200 ENOG4105IQ5 FAD linked oxidase domain protein FOC74_17215 ENOG4105D01 (LipO)protein FOC74_17220 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC74_17225 ENOG4108UMI ABC transporter, permease FOC74_17230 ENOG4108PSK reductase FOC74_17260 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FOC74_17265 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FOC74_17275 ENOG4105CMG Carbohydrate kinase FOC74_17285 ENOG4108VQT Alpha beta hydrolase fold protein FOC74_17310 ENOG4107U5W ybbr family FOC74_17315 ENOG4105C8B TIGR00159 family FOC74_17395 ENOG4108NMV polysaccharide deacetylase FOC74_17410 ENOG4105D1F ATP-binding protein FOC74_17440 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC74_17485 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC74_17495 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC74_17625 ENOG4105XPM ribosomal protein FOC74_17640 ENOG4107Y49 methyltransferase FOC74_17665 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOC74_17680 ENOG4105QIV RNA polymerase FOC74_17685 ENOG4105M0M Tetracycline resistance protein FOC74_17690 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOC74_17705 ENOG4105D7W serine acetyltransferase FOC74_17725 ENOG4105CTP PilT protein domain protein FOC74_17735 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOC74_17750 ENOG4108Z0C Uvrb UvrC protein FOC74_17840 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC74_17850 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOC74_17855 ENOG4105KRF dihydroneopterin aldolase FOC74_17860 ENOG4105EEI dihydropteroate synthase FOC74_17865 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FOC74_17870 ENOG4105DDQ anthranilate synthase FOC74_17875 ENOG4105CRQ synthase (Component I) FOC74_17880 ENOG4105C6T cysteine synthase FOC74_17895 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC74_17900 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC74_17925 ENOG41060GV RNA binding s1 domain protein FOC74_17940 ENOG4105VYY sporulation protein yabp FOC74_17945 ENOG41082I2 s4 domain protein FOC74_17950 ENOG4108IY2 MazG family FOC74_17960 ENOG4108M14 stage v sporulation protein t FOC74_17965 ENOG4108JA2 transcriptioN-repair coupling factor FOC74_17995 ENOG4105KME endoribonuclease L-psp FOC74_18000 ENOG4105DFT pur operon repressor FOC74_18015 ENOG4105W42 Veg protein FOC74_18020 ENOG4105XFA sporulation peptidase YabG FOC74_18030 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FOC74_18035 ENOG4105F8V Hydrolase, tatD family FOC74_18045 ENOG4105KRN Transcriptional regulator, abrb family FOC74_18050 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOC74_18060 ENOG41060K3 Methyltransferase FOC74_18070 ENOG4105MA4 psp1 domain protein FOC74_18075 ENOG4105FA2 dna polymerase iii FOC74_18085 ENOG4105CXN decarboxylase FOC74_18120 ENOG41067KS pro-sigma K processing FOC74_18140 ENOG4105C6E dna polymerase iii FOC74_18150 ENOG4108Z6B deaminase FOC74_18155 ENOG4105GTG Isochorismatase FOC74_18165 ENOG4105ZMH deoxynucleoside kinase FOC74_18200 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOC74_18235 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC74_18250 ENOG410848D S4 domain protein YaaA FOC74_18255 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC74_18275 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC74_18305 ENOG4107QJE Chromosome Partitioning Protein FOC74_18310 ENOG4105FA0 parb-like partition protein FOC74_18315 ENOG4108ZDA Sporulation protein YyaC FOC74_18320 ENOG4105D8X mechanosensitive ion channel FOC74_18325 ENOG4105VDK protein, conserved in bacteria FOC74_18330 ENOG4105C3G gtp-binding protein FOC74_18340 ENOG4108UUM single-stranded DNA-binding protein FOC74_18350 ENOG4108XMW Membrane FOC74_18355 ENOG4105BZR domain protein FOC74_18365 ENOG4105CDU Replicative dna helicase FOC74_18395 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC74_18400 ENOG4105BZU Histidine kinase FOC74_18415 ENOG4105Q2H domain protein FOC74_18420 ENOG4105C0H protease FOC74_18440 ENOG4105DPN Oligoendopeptidase f FOC74_18455 ENOG4105C1J atp-dependent rna helicase FOC74_18465 ENOG4108UT2 hemolysin iii FOC74_18470 ENOG4105CMR udp-glucose 4-epimerase FOC74_18480 ENOG4105IW1 AmiS UreI transporter FOC74_18490 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC74_18505 ENOG4107RGD Major Facilitator superfamily FOC74_18510 ENOG4108HRK Histidine kinase FOC74_18515 ENOG4105DY9 regulatoR FOC74_18530 ENOG4106F5Q Membrane FOC74_18535 ENOG4105E0X reductase FOC74_18545 ENOG41067SE Tetr family transcriptional regulator FOC74_18550 ENOG4105CKK Glycosyl transferase, family 2 FOC74_18570 ENOG4105C5H ABC transporter FOC74_18575 ENOG4105JEU Glycosyl transferase, family 2 FOC74_18585 ENOG4108S4H thioesterase Superfamily protein FOC74_18595 ENOG4106YBV Methyl-accepting chemotaxis FOC74_18600 ENOG4105EN6 Membrane FOC74_18620 ENOG41079KZ Major Facilitator Superfamily FOC74_18625 ENOG4105DY9 regulatoR FOC74_18630 ENOG4105D22 carbon starvation protein FOC74_18635 ENOG4105VCD cytoplasmic protein FOC74_18640 ENOG4105BZU Histidine kinase FOC74_18645 ENOG4105DWF phosphomethylpyrimidine kinase FOC74_18650 ENOG4105BZU Histidine kinase FOC74_18655 ENOG4105WH1 Two component transcriptional regulator luxr family FOC74_18665 ENOG4108Y4K DNA-binding transcriptional activator FOC74_18690 ENOG4105D6E homoserine dehydrogenase FOC74_18705 ENOG41090WU lipolytic protein G-D-S-L family FOC74_18710 ENOG4105CJ1 ABC, transporter FOC74_18715 ENOG4108TU7 Inherit from COG: (ABC) transporter FOC74_18725 ENOG4105VCH membrane FOC74_18730 ENOG410667J hydrolase FOC74_18740 ENOG4107SVH Potassium channel protein FOC74_18760 ENOG4108VKI Cell wall hydrolase FOC74_18775 ENOG4108IJ2 phosphate acetyltransferase FOC74_18795 ENOG4108VCI transcription factor, rsfa family FOC74_18805 ENOG4105DQ5 transport system permease protein FOC74_18810 ENOG4105EHG Permease protein FOC74_18815 ENOG4105E0A ABC, transporter FOC74_18820 ENOG4108MES Periplasmic binding protein FOC74_18825 ENOG4105DCI Phosphohydrolase FOC74_18830 ENOG41069HH 4-oxalocrotonate tautomerase FOC74_18835 ENOG4108Z4T Peptidase M50 FOC74_18840 ENOG4108XFG YwhD family FOC74_18845 ENOG4105BZ4 penicillin-binding protein FOC74_18850 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC74_18855 ENOG4107SWG transcriptional regulator MERR family FOC74_18860 ENOG4105DXB Major Facilitator superfamily FOC74_18870 ENOG4105CYW agmatinase FOC74_18890 ENOG410684U Domain of unknown function (DUF1934) FOC74_18900 ENOG4105EMN RNA polymerase sigma factor FOC74_18920 ENOG4105IIU Aminopeptidase FOC74_18930 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FOC74_18960 ENOG4105BZU Histidine kinase FOC74_18975 ENOG4105DF6 Fe-S oxidoreductase FOC74_18985 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC74_18990 ENOG4105C1G acyl-Coa dehydrogenase FOC74_18995 ENOG4105C1G acyl-Coa dehydrogenase FOC74_19035 ENOG4105CBT Fructose-1,6-bisphosphatase FOC74_19040 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOC74_19060 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC74_19065 ENOG4108ZXQ stage ii sporulation protein r FOC74_19075 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC74_19090 ENOG4107XC4 flavin reductase domain protein, FMN-binding FOC74_19095 ENOG4108VGI doxx family FOC74_19110 ENOG4108YZG isomerase FOC74_19140 ENOG41062M3 atp synthase FOC74_19145 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FOC74_19195 ENOG4105BZU Histidine kinase FOC74_19210 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC74_19215 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC74_19240 ENOG4105D65 subunit l FOC74_19245 ENOG4105C8S subunit m FOC74_19250 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC74_19255 ENOG4106778 Protein of unknown function (DUF1146) FOC74_19275 ENOG4105DY9 regulatoR FOC74_19290 ENOG4105FRN stage II sporulation protein FOC74_19300 ENOG4107BJW polysaccharide deacetylase FOC74_19305 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FOC74_19315 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase FOC74_19320 ENOG4107RZX Teichoic acid biosynthesis protein FOC74_19325 ENOG4107SJB teichoic acid biosynthesis FOC74_19330 ENOG4107SJB teichoic acid biosynthesis FOC74_19340 ENOG4105EY8 ABC transporter FOC74_19345 ENOG4107VDP teichoic acid biosynthesis FOC74_19350 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC74_19365 ENOG4105CMR udp-glucose 4-epimerase FOC74_19370 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC74_19375 ENOG4105BZU Histidine kinase FOC74_19390 ENOG4105CXY transporter FOC74_19400 ENOG4105C19 ABC transporter FOC74_19405 ENOG4107RBB ABC transporter, permease FOC74_19420 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC74_19450 ENOG4105C0D helicase FOC74_19455 ENOG4105KBK Zinc finger, swim domain protein FOC74_19480 ENOG41069ER domain protein FOC74_19485 ENOG4105C94 Transporter FOC74_19490 ENOG4107R8N Glycosyl transferase, family 2 FOC74_19515 ENOG4105E0M Sulfatase FOC74_19525 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FOC74_19535 ENOG4105DAA L-lactate FOC74_19590 ENOG4107RSM transcriptional regulator FOC74_19595 ENOG4105ECB domain protein FOC74_19600 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FOC74_19615 ENOG4105VZJ PTS System FOC74_19625 ENOG4105VCP PTS System FOC74_19635 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FOC74_19645 ENOG4105CK1 PTS System FOC74_19650 ENOG4105VCP PTS System FOC74_19655 ENOG4105F8D glycoside hydrolase family 4 FOC74_19675 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC74_19685 ENOG4105ESV Glycosyl transferase, family 4 FOC74_19690 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC74_19695 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC74_19700 ENOG4108KGH TRANSCRIPTIONal FOC74_19705 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOC74_19715 ENOG4105KVH Transcriptional regulator FOC74_19730 ENOG41081UC Inherit from COG: Competence protein FOC74_19735 ENOG4105VEQ Cold shock protein FOC74_19740 ENOG4105MS2 ribosomal subunit Interface protein FOC74_19760 ENOG4105CAK Cell division ATP-binding protein ftsE FOC74_19765 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOC74_19770 ENOG4105CN1 protease FOC74_19780 ENOG4105BZ1 (ABC) transporter FOC74_19795 ENOG4108WS4 fmn reductase FOC74_19805 ENOG4105DUM transcriptional regulator, lysR family FOC74_19810 ENOG4105HMI Membrane FOC74_19840 ENOG4107TXC Transcriptional regulator FOC74_19855 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOC74_19860 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC74_19870 ENOG41086DT Membrane protein of unknown function FOC74_19890 ENOG4108S4C acetyltransferase FOC74_19900 ENOG4105C3M thioredoxin reductase FOC74_19910 ENOG4108Z4K mutator MutT protein FOC74_19920 ENOG4105CHW UPF0052 protein FOC74_19930 ENOG4105KRI phosphocarrier protein (HPr FOC74_19940 ENOG4105H67 Protein of unknown function (DUF421) FOC74_19955 ENOG4105CZ3 stage V sporulation protein ad FOC74_19960 ENOG41090VF Stage v sporulation protein ac FOC74_19980 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC74_20030 ENOG41067MG lrgb family FOC74_20035 ENOG4105XZU Preprotein translocase, subunit SecG FOC74_20045 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOC74_20065 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC74_20080 ENOG4105CM4 permease protein FOC74_20085 ENOG4108IPW abc transporter atp-binding protein FOC74_20105 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC74_20135 ENOG4105C8Q Methyl-accepting chemotaxis FOC74_20160 ENOG4105D4A Cell wall formation (By similarity) FOC74_20165 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC74_20180 ENOG4105KVH Transcriptional regulator FOC74_20185 ENOG4105F27 Major Facilitator FOC74_20190 ENOG4105CV8 reductase FOC74_20210 ENOG4108RYK Nad-dependent epimerase dehydratase FOC74_20220 ENOG4105D9N nucleoside FOC74_20225 ENOG4105D9N nucleoside FOC74_20245 ENOG4108URH decarboxylase FOC74_20260 ENOG4108RMU ferritin dps family protein FOC74_20270 ENOG4105NCW Trka-c domain protein FOC74_20275 ENOG4107S91 Sodium hydrogen exchanger FOC74_20295 ENOG4105D4Y metalloprotease FOC74_20300 ENOG4105VG1 fes assembly suf system protein FOC74_20305 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC74_20310 ENOG4105C8Q Methyl-accepting chemotaxis FOC74_20330 ENOG4105BZU Histidine kinase FOC74_20335 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC74_20340 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC74_20350 ENOG4107ZTW SNARE associated Golgi FOC74_20385 ENOG4107AYK membrAne FOC74_20395 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC74_20405 ENOG4107R7I amino acid FOC74_20410 ENOG4108SUT Major Facilitator Superfamily FOC74_20430 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC74_20450 ENOG4105DZ1 carboxypeptidase FOC74_20465 ENOG4105CHU acetyl-coa acetyltransferase FOC74_20475 ENOG4105C1G acyl-Coa dehydrogenase FOC74_20480 ENOG4108W8B Beta-lactamase domain protein FOC74_20490 ENOG4108IMY Transcriptional regulator FOC74_20560 ENOG41080E8 Transcriptional regulator, Spx MgsR family FOC74_20590 ENOG4108UMI ABC transporter, permease FOC74_20595 ENOG4105D01 (LipO)protein FOC74_20600 ENOG4105D01 (LipO)protein FOC74_20605 ENOG4105C3K feS assembly ATPase SufC FOC74_20610 ENOG4105JRK feS assembly protein SufD FOC74_20615 ENOG4105C9B Cysteine desulfurase FOC74_20620 ENOG4108UNV SUF system FeS assembly protein, NifU family FOC74_20625 ENOG4105DIW FeS assembly protein SUFB FOC74_20630 ENOG4107R8B 5'-nucleotidase FOC74_20635 ENOG4105KZD Domain of unknown function (DUF1805) FOC74_20645 ENOG4105FAA peptidase M23 FOC74_20670 ENOG41090T1 Membrane FOC74_20675 ENOG4107TXC Transcriptional regulator FOC74_20680 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FOC74_20685 ENOG4105MMD transcriptional regulator FOC74_20700 ENOG4105CBT Fructose-1,6-bisphosphatase FOC74_20715 ENOG4105D4U had-superfamily hydrolase, subfamily iia FOC74_20725 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC74_20735 ENOG4108W5N phosphatidylglycerophosphatase a FOC74_20750 ENOG41083MR nifu domain-containing protein FOC74_20775 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOC74_20780 ENOG4105C4B ABC transporter, permease FOC74_20785 ENOG4108JJA ABC, transporter FOC74_20810 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOC74_20820 ENOG4105EWC Purine nucleoside phosphorylase FOC74_20850 ENOG4105CEP NADH dehydrogenase FOC74_20870 ENOG41069ER domain protein FOC74_20890 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC74_20905 ENOG4105KA0 thioesterase Superfamily protein FOC74_20925 ENOG4107R3E Citrate transporter FOC74_20935 ENOG4105Y38 Kinase-associated protein B FOC74_20950 ENOG4105C87 Aminotransferase class I and II FOC74_20960 ENOG4108MUZ hydrolase FOC74_20965 ENOG4105C5I Dehydrogenase FOC74_20970 ENOG4108ZB6 transcriptional regulator AsnC family FOC74_20975 ENOG4105CHM Aminotransferase FOC74_20985 ENOG4105WG9 Conserved Protein FOC74_21000 ENOG4107PBV potassium channel FOC74_21005 ENOG4105KT7 mgtC SapB transporter FOC74_21040 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOC74_21135 ENOG4105JVQ RNA Polymerase FOC74_21195 ENOG4105VEQ Cold shock protein FOC74_21205 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC74_21210 ENOG4105E4F Isochorismate synthase FOC74_21220 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FOC74_21225 ENOG4108IPT Naphthoate synthase FOC74_21235 ENOG4105DTQ mandelate racemase muconate lactonizing FOC74_21265 ENOG41069H0 dihydroorotase EC 3.5.2.3 FOC74_21330 ENOG41086D8 Transcriptional regulator FOC74_21335 ENOG4105C19 ABC transporter FOC74_21350 ENOG4107ZTW SNARE associated Golgi FOC74_21375 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FOC74_21380 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC74_21405 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC74_21410 ENOG4105BZU Histidine kinase FOC74_21450 ENOG41087YS Phage shock protein A FOC74_21495 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC74_21500 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC74_21505 ENOG4108V2W Carbonate dehydratase FOC74_21550 ENOG4107XGZ Hydrolase FOC74_21565 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOC74_21575 ENOG4105D2X ABC transporter substrate-binding protein FOC74_21590 ENOG4107T7U Sulfatase FOC74_21595 ENOG4107S9D Alpha beta hydrolase FOC74_21600 ENOG4105BZU Histidine kinase FOC74_21605 ENOG4105BZU Histidine kinase FOC74_21610 ENOG4105EGD dinuclear metal center protein, YbgI family FOC74_21665 ENOG4108RIR Molybdenum cofactor biosynthesis protein FOC74_21675 ENOG4105BZF Glycosyl transferase (Group 1 FOC74_21680 ENOG4105YVM Phosphoesterase, PA-phosphatase related FOC74_21685 ENOG4108Z0R Transferase FOC74_21690 ENOG4105E8V Alpha Beta Hydrolase Fold protein FOC74_21720 ENOG4105CIG ABC transporter FOC74_21730 ENOG4105N5T Radical SAM Protein FOC74_21750 ENOG4105C19 ABC transporter FOC74_21765 ENOG4105NCW Trka-c domain protein FOC74_21770 ENOG4107S91 Sodium hydrogen exchanger FOC74_21775 ENOG410605W Major Facilitator FOC74_21805 ENOG4108B31 Spore germination protein FOC74_21815 ENOG4105DWV Homoserine O-trans-acetylase FOC74_21825 ENOG41085GJ domain protein FOC74_21845 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC74_21850 ENOG4105D06 uba thif-type nad fad binding protein FOC74_21860 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC74_21865 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FOC74_21870 ENOG4108ZAF Molybdopterin FOC74_21890 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC74_21895 ENOG4108VJ1 Transcriptional regulator (CarD family FOC74_21930 ENOG4105CBX hi0933 family FOC74_21945 ENOG4105YW5 deoR family transcriptional regulator FOC74_21950 ENOG4107QSE Dipeptidase FOC74_21960 ENOG4108IUM Glycogen debranching enzyme FOC74_21965 ENOG4108V15 phosphotransferase enzyme family FOC74_21980 ENOG4105C8F Beta-lactamase domain protein FOC74_22010 ENOG4108VDD TRNA binding domain protein FOC74_22060 ENOG4105C88 aminopeptidase FOC74_22080 ENOG4105ETE Transcriptional regulator (LacI family FOC74_22110 ENOG4105EP9 oxidoreductase FOC74_22115 ENOG4107SNB ankyrin repeat protein YahD FOC74_22125 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC74_22135 ENOG4106HB6 Alpha beta hydrolase FOC74_22140 ENOG4105DGU Histone deacetylase FOC74_22145 ENOG4105W87 Cbs domain FOC74_22150 ENOG4105F1V Acetoin utilization protein FOC74_22165 ENOG4105EMN RNA polymerase sigma factor FOC74_22195 ENOG4105C28 cystathionine FOC74_22205 ENOG4105U5Y Transcriptional regulator FOC74_22215 ENOG4106KR7 LysR family Transcriptional regulator FOC74_22240 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC74_22250 ENOG4105EFZ amidohydrolase FOC74_22265 ENOG4105KBJ sporulation protein ytfj FOC74_22270 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FOC74_22300 ENOG4108JYZ YitT family FOC74_22340 ENOG4107YZX Universal stress protein FOC74_22360 ENOG4105VZ8 Transcriptional regulator FOC74_22370 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC74_22415 ENOG4105DC7 peptidase M24 FOC74_22450 ENOG4105SFS phosphoesterase RecJ domain protein FOC74_22460 ENOG4105VV2 FOC74_22465 ENOG4105C0B DNA polymerase III (alpha subunit) FOC74_22470 ENOG4105C6K Malic enzyme FOC74_22475 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC74_22500 ENOG4105FS0 cytoplasmic membrane protein FOC74_22505 ENOG4108REF Sporulation integral membrane protein ytvi FOC74_22515 ENOG4105BZN citrate synthase FOC74_22520 ENOG4108HMX isocitrate dehydrogenase (NADP) FOC74_22540 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC74_22545 ENOG4105BZU Histidine kinase FOC74_22550 ENOG4105C2M dna polymerase I FOC74_22565 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOC74_22570 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOC74_22595 ENOG4108TDW sporulation protein YtxC FOC74_22600 ENOG4105C22 threonyL-tRNA synthetase FOC74_22625 ENOG4105CN9 Peptidase m42 family protein FOC74_22630 ENOG4108JGH Tetr family transcriptional regulator FOC74_22635 ENOG4105CW7 secretion protein, HlyD family FOC74_22640 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC74_22675 ENOG4108RWN rrna methyltransferase FOC74_22725 ENOG4105DCG PHP domain protein FOC74_22735 ENOG4105FE9 pseudouridine synthase FOC74_22745 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FOC74_22755 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FOC74_22770 ENOG4105E0A ABC, transporter FOC74_22775 ENOG4105KFN sortase, SrtB family FOC74_22790 ENOG4105DR4 Methyltransferase FOC74_22805 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC74_22845 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC74_22850 ENOG4105J76 Periplasmic binding protein FOC74_22860 ENOG4105CEY Amp-dependent synthetase and ligase FOC74_22865 ENOG4107Z3H Transcriptional regulator, TetR family FOC74_22870 ENOG41060WC Enoyl-CoA hydratase FOC74_22875 ENOG4105BZJ Electron transfer flavoprotein FOC74_22880 ENOG4105C10 Electron transfer flavoprotein FOC74_22885 ENOG4105K63 Thioredoxin FOC74_22900 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FOC74_22910 ENOG4105E33 succinate dehydrogenase FOC74_22920 ENOG4108VXD carboxy-peptidase FOC74_22925 ENOG4105E14 MotA TolQ exbB proton channel FOC74_22930 ENOG4105ER2 Ompa motb domain protein FOC74_22935 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FOC74_22940 ENOG4108IUX (ABC) transporter FOC74_22945 ENOG4105RHA ABC transporter, permease FOC74_22950 ENOG4108Z40 Transcriptional regulator FOC74_22955 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOC74_22965 ENOG4108JCI Transcriptional regulator FOC74_22970 ENOG41067S9 phage shock protein C, PspC FOC74_22980 ENOG4105DY9 regulatoR FOC74_22985 ENOG4108HRK Histidine kinase FOC74_22990 ENOG4108JQ7 (ABC) transporter FOC74_23005 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC74_23010 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC74_23015 ENOG4105DZC cytosine deaminase FOC74_23020 ENOG4105DZC cytosine deaminase FOC74_23035 ENOG4105PFC Transcriptional regulator FOC74_23060 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC74_23085 ENOG4105D6J arsenicaL-resistance protein FOC74_23100 ENOG41082YX Transcriptional regulator, arsr family FOC74_23125 ENOG410904A RNA polymerase FOC74_23130 ENOG41089UC methyltransferase, type 11 FOC74_23165 ENOG4105PFC Transcriptional regulator FOC74_23180 ENOG4105KBX Transcriptional regulator, TetR family FOC74_23190 ENOG4108PCX Major Facilitator FOC74_23200 ENOG4108XJQ germination protein FOC74_23215 ENOG4105M59 Phosphodiesterase, mj0936 family FOC74_23235 ENOG4108QCI YvbH-like oligomerisation region FOC74_23265 ENOG4108IUQ atp-dependent protease FOC74_23285 ENOG4105K56 Transcriptional regulator FOC74_23310 ENOG4105D52 delta-aminolevulinic acid dehydratase FOC74_23320 ENOG41068KH stage VI sporulation protein D FOC74_23330 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FOC74_23335 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC74_23355 ENOG4105DFF Rod shape-determining protein mreb FOC74_23375 ENOG4107QMS site-determining protein FOC74_23390 ENOG4105C03 ribonuclease FOC74_23400 ENOG4105X36 (ribosomal) protein FOC74_23425 ENOG4105EWM Histidine kinase FOC74_23445 ENOG4105CQC Prephenate dehydratase FOC74_23450 ENOG4108RPX mosc domain containing protein FOC74_23465 ENOG4108IYU L-aspartate oxidase FOC74_23470 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOC74_23500 ENOG4108HUF Transporter FOC74_23515 ENOG41061AI Protein of unknown function (DUF2905) FOC74_23530 ENOG4105VIE preprotein translocase, subunit YajC FOC74_23540 ENOG4108QG2 Membrane FOC74_23545 ENOG4105CKP Polysaccharide Biosynthesis Protein FOC74_23555 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC74_23560 ENOG41076HS cation diffusion facilitator family transporter FOC74_23565 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC74_23575 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC74_23605 ENOG4105CUZ uba thif-type nad fad binding protein FOC74_23610 ENOG4108VCI transcription factor, rsfa family FOC74_23615 ENOG4105D1H recombination factor protein RarA FOC74_23625 ENOG4105C3J Cysteine desulfurase FOC74_23640 ENOG4105C7H Helicase, RecD TraA family FOC74_23645 ENOG41060CR FOC74_23660 ENOG4105C02 permease FOC74_23690 ENOG4105HHA aminodeoxychorismate lyase FOC74_23700 ENOG4105XYU peptidase (U32 family) FOC74_23705 ENOG4105CFP Peptidase U32 FOC74_23720 ENOG4107XRG penicillin-binding protein FOC74_23750 ENOG4105C28 cystathionine FOC74_23755 ENOG4105C0A alcohol dehydrogenase FOC74_23765 ENOG4108V5C ABC transporter FOC74_23770 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC74_23810 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC74_23820 ENOG4105MIR Phenylalanine 4-monooxygenase FOC74_23825 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC74_23860 ENOG4108MUZ hydrolase FOC74_23870 ENOG4105G6Z alkaline phosphatase FOC74_23885 ENOG4108TVJ Nitroreductase FOC74_23905 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC74_23920 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FOC74_23925 ENOG4105CQW ribosome biogenesis GTPase YqeH FOC74_23935 ENOG410812S Rna-binding protein FOC74_23945 ENOG4108WF2 Metal Dependent Phosphohydrolase FOC74_23955 ENOG4105DXX methyltransferase FOC74_23965 ENOG4105KQC Competence protein FOC74_23970 ENOG4108UK2 deaminase FOC74_23975 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC74_23985 ENOG4105TQK DNA polymerase iii, delta' subunit FOC74_24010 ENOG4105KVH Transcriptional regulator FOC74_24015 ENOG4105CSA Coproporphyrinogen iii oxidase FOC74_24045 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOC74_24050 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC74_24060 ENOG4105KTH gatB Yqey FOC74_24065 ENOG41068P3 sporulation protein YqfC FOC74_24075 ENOG4105C9A Phoh family FOC74_24080 ENOG4105CTJ Metal Dependent Phosphohydrolase FOC74_24090 ENOG4107YR5 Diacylglycerol kinase FOC74_24095 ENOG4105KG3 cytidine deaminase FOC74_24100 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOC74_24130 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOC74_24135 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC74_24150 ENOG4105EGD dinuclear metal center protein, YbgI family FOC74_24175 ENOG41069ZM Protein of unknown function (DUF2624) FOC74_24180 ENOG4108JYZ YitT family FOC74_24185 ENOG4105FDK ABC transporter FOC74_24195 ENOG4105N80 Ferric uptake regulator, Fur family FOC74_24220 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC74_24230 ENOG4107RF6 penicillin-binding protein FOC74_24235 ENOG4105PWN phosphate abc transporter FOC74_24240 ENOG4105C8U phosphate abc transporter FOC74_24245 ENOG4105E2Z phosphate ABC transporter (Permease FOC74_24255 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOC74_24270 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOC74_24280 ENOG4105DKQ ROK family FOC74_24290 ENOG4105C5X domain protein FOC74_24310 ENOG4105C28 cystathionine FOC74_24315 ENOG4105C28 cystathionine FOC74_24325 ENOG4105C3R Methionine synthase FOC74_24330 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC74_24555 ENOG4105C0D helicase FOC74_24585 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC74_24590 ENOG4105CJ1 ABC, transporter FOC74_24625 ENOG41080TC multidrug resistance protein FOC74_24645 ENOG4105WZW rhodanese family FOC74_24650 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FOC74_24670 ENOG4107YBY Hydrolase FOC74_24680 ENOG4105CBJ Metal-dependent enzyme FOC74_24695 ENOG4105DC7 peptidase M24 FOC74_24720 ENOG4105CD2 stage iii sporulation protein aa FOC74_24725 ENOG4105KR5 Stage iii sporulation protein FOC74_24730 ENOG4108CQH stage III sporulation protein AC FOC74_24735 ENOG4105KQ4 Stage iii sporulation protein ad FOC74_24745 ENOG410644B Stage III sporulation protein af FOC74_24770 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC74_24775 ENOG4108ZSR alkaline shock protein FOC74_24800 ENOG4105CTB Polyprenyl synthetase FOC74_24810 ENOG4105DX0 Hemolysin A FOC74_24820 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOC74_24825 ENOG4105S1Z Stage IV sporulation protein B FOC74_24830 ENOG4107QQR Sporulation FOC74_24845 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC74_24855 ENOG4108JUB Transcriptional regulator FOC74_24865 ENOG4107RDP Dehydrogenase FOC74_24885 ENOG4105CPP Dehydrogenase, E1 component FOC74_24890 ENOG4105C7S Dehydrogenase FOC74_24900 ENOG4105E09 nadh pyrophosphatase FOC74_24905 ENOG4105G7B Protein of unknown function (DUF2992) FOC74_24915 ENOG4108HW3 (ABC) transporter FOC74_24920 ENOG4105E5Q amino acid AbC transporter FOC74_24925 ENOG4105CDA abc transporter atp-binding protein FOC74_24930 ENOG4108QEG Membrane FOC74_24935 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FOC74_24950 ENOG4105D9U N-acetyltransferase FOC74_24955 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOC74_24965 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC74_24990 ENOG4105EJQ L-serine dehydratase FOC74_24995 ENOG4105II7 pyrroline-5-carboxylate reductase FOC74_25000 ENOG41069FQ Metallo-beta-lactamase superfamily FOC74_25005 ENOG4108IXY short-chain dehydrogenase reductase FOC74_25020 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FOC74_25060 ENOG4105CGH 5'-nucleotidase FOC74_25065 ENOG4105DFD Na H antiporter FOC74_25075 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC74_25090 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC74_25095 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC74_25120 ENOG4108R6K riboflavin synthase, subunit alpha FOC74_25125 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC74_25145 ENOG4108YM7 Gcn5-related n-acetyltransferase FOC74_25150 ENOG4105ETE Transcriptional regulator (LacI family FOC74_25160 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC74_25180 ENOG4105RHY Pfam:UPF0157 FOC74_25190 ENOG4105CPC Aldo Keto reductase FOC74_25210 ENOG4105MZ9 stage II sporulation protein m FOC74_25215 ENOG4105I3K Ferric uptake regulator, Fur family FOC74_25225 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC74_25250 ENOG4105D7N magnesium and cobalt transport protein CorA FOC74_25280 ENOG4105DVE abc transporter atp-binding protein FOC74_25285 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC74_25290 ENOG4105DZ1 carboxypeptidase FOC74_25295 ENOG41082AN stage II sporulation protein FOC74_25305 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC74_25310 ENOG4105C8J )-transporter FOC74_25330 ENOG41090VF Stage v sporulation protein ac FOC74_25335 ENOG4105CZ3 stage V sporulation protein ad FOC74_25345 ENOG4105G6R Stage v sporulation protein ae FOC74_25355 ENOG4105J7I hydrolase FOC74_25360 ENOG4105PTM secreted protein FOC74_25365 ENOG4107ZE5 PPIases accelerate the folding of proteins FOC74_25400 ENOG4105CE4 GlcNAc 6-P deacetylase FOC74_25420 ENOG4105CID antiterminator FOC74_25435 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOC74_25455 ENOG4106TD9 Diguanylate cyclase FOC74_25460 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC74_25500 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOC74_25520 ENOG4105DTD Dehydrogenase FOC74_25560 ENOG4105CHU acetyl-coa acetyltransferase FOC74_25605 ENOG4105CG3 alpha amylase, catalytic region FOC74_25615 ENOG4107FKK extracellular solute-binding protein family 1 FOC74_25625 ENOG4105EG2 ABC transporter, permease FOC74_25630 ENOG4105FKQ transcriptional regulator FOC74_25635 ENOG4105CHM Aminotransferase FOC74_25645 ENOG4108HGU Histidine kinase FOC74_25700 ENOG4105UIN FOC74_25710 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FOC74_25725 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FOC74_25730 ENOG4105EPM Diguanylate phosphodiesterase FOC74_25745 ENOG4107IN1 Protein of unknown function (DUF1797) FOC74_25755 ENOG4108XRC Protein of unknown function (DUF458) FOC74_25790 ENOG4107ZYR domain protein FOC74_25795 ENOG4105CN5 Metallo-Beta-Lactamase FOC74_25805 ENOG4108X4Q Hydrolase FOC74_25810 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC74_25825 ENOG4105CPP Dehydrogenase, E1 component FOC74_25875 ENOG4105CXN decarboxylase FOC74_25895 ENOG4105ECY inositol monophosphatase FOC74_25905 ENOG4105CI3 gtp-binding protein typa FOC74_25910 ENOG4105QA2 FOC74_25930 ENOG4108IAB Phoh family FOC74_25945 ENOG4105CNI cell division protein FtsW FOC74_25950 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FOC74_25995 ENOG4105EKQ RNA-directed DNA polymerase FOC74_26010 ENOG4106UY4 Inherit from COG: Scp-like extracellular FOC74_26025 ENOG4107TB6 phosphoglycerate mutase FOC74_26045 ENOG4106H78 methyltransferase FOC74_26055 ENOG4105H20 Sporulation integral membrane protein YlbJ FOC74_26060 ENOG4105D78 K07001 NTE family protein FOC74_26065 ENOG41063PX domain protein FOC74_26075 ENOG4105KNH Nucleic acid-binding protein FOC74_26110 ENOG41068DC Essential cell division protein (By similarity) FOC74_26115 ENOG4105CJN penicillin-binding protein FOC74_26120 ENOG4105CJN penicillin-binding protein FOC74_26125 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC74_26140 ENOG4105CNI cell division protein FtsW FOC74_26150 ENOG4105D4A Cell wall formation (By similarity) FOC74_26155 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FOC74_26160 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOC74_26165 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOC74_26175 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC74_26185 ENOG4105WR5 sporulation protein, YlmC YmxH family FOC74_26190 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOC74_26195 ENOG4105DFA alanine racemase domain protein FOC74_26205 ENOG41067XK integral membrane protein FOC74_26210 ENOG4105DBK s4 domain protein FOC74_26235 ENOG4105C34 Pseudouridine synthase FOC74_26315 ENOG4105DC7 peptidase M24 FOC74_26330 ENOG4105DSJ YicC domain protein FOC74_26350 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOC74_26355 ENOG4105C25 Primosomal protein n' FOC74_26360 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC74_26370 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOC74_26380 ENOG4108ZF3 Phosphatase FOC74_26385 ENOG4105D9P serine threonine protein kinase FOC74_26390 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC74_26395 ENOG4105DJV ribulose-phosphate 3-epimerase FOC74_26400 ENOG4105FJ0 thiamine FOC74_26415 ENOG4108ZAA Alkaline-shock protein FOC74_26420 ENOG4105DP4 dak2 domain fusion protein ylov FOC74_26425 ENOG4105CB5 ATP-dependent DNA helicase recG FOC74_26440 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC74_26445 ENOG4105CHR reductase FOC74_26460 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOC74_26465 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOC74_26485 ENOG4105VB6 UPF0109 protein FOC74_26510 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FOC74_26525 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOC74_26530 ENOG4105C79 DNA protecting protein DprA FOC74_26535 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOC74_26545 ENOG4108HE4 integrase family FOC74_26590 ENOG4105KNE Phosphatidate cytidylyltransferase FOC74_26600 ENOG4105DZP Membrane-associated zinc metalloprotease FOC74_26610 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC74_26620 ENOG4105CHV Transcription elongation factor NusA FOC74_26625 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FOC74_26630 ENOG4105VHM ribosomal protein FOC74_26640 ENOG4105W7A Protein of unknown function (DUF503) FOC74_26650 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FOC74_26655 ENOG4105DTN riboflavin biosynthesis protein ribF FOC74_26675 ENOG4105C1V Peptidase, M16 FOC74_26685 ENOG4105E35 Dipicolinate synthase subunit A FOC74_26690 ENOG4108S0H Dipicolinic acid synthetase, b subunit FOC74_26695 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC74_26705 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC74_26715 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FOC74_26725 ENOG4107QZI cell division protein FtsK FOC74_26730 ENOG4105FDP GntR family transcriptional regulator FOC74_26735 ENOG4105DIH basic membrane FOC74_26740 ENOG4108JQ9 ABC transporter FOC74_26745 ENOG4105UIB (ABC) transporter FOC74_26765 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FOC74_26770 ENOG4105XZV Protein of unknown function (DUF3243) FOC74_26785 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOC74_26810 ENOG4105D48 metallophosphoesterase FOC74_26815 ENOG4105MCT stage V sporulation protein S FOC74_26820 ENOG4108IGT Dipeptidase FOC74_26825 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FOC74_26830 ENOG4105DQU oxidoreductase, subunit beta FOC74_26860 ENOG4107QHE Choloylglycine hydrolase FOC74_26870 ENOG410890F Dynamin family FOC74_26875 ENOG4105E0M Sulfatase FOC74_26880 ENOG4107R6R udp-galactopyranose mutase FOC74_26885 ENOG4105F0V Cell wall hydrolase FOC74_26910 ENOG4107YEI lmbE family FOC74_26915 ENOG4107TTQ Alpha beta hydrolase fold FOC74_26930 ENOG41067MG lrgb family FOC74_26945 ENOG4105BZU Histidine kinase FOC74_26950 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC74_26980 ENOG4105D03 DNA-3-methyladenine glycosylase II FOC74_26985 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC74_26995 ENOG4105CGK Exodeoxyribonuclease III FOC74_27015 ENOG4105E0A ABC, transporter FOC74_27020 ENOG4105NIV Esterase FOC74_27030 ENOG4105VPX protein, conserved in bacteria FOC74_27035 ENOG410681U heavy metal transport detoxification protein FOC74_27040 ENOG4105C59 p-type ATPase FOC74_27050 ENOG4105K70 DNA-binding protein FOC74_27055 ENOG4105TMB Formate nitrite transporter FOC74_27075 ENOG4105C85 amino acid FOC74_27085 ENOG4108SJC Membrane FOC74_27090 ENOG4107QW4 alcohol dehydrogenase FOC74_27095 ENOG4105E98 transcriptional regulator DeoR family FOC74_27100 ENOG4105DE4 1-phosphofructokinase FOC74_27105 ENOG4105DM4 PTS System FOC74_27110 ENOG41069ER domain protein FOC74_27140 ENOG4106F1P AAA ATPase, central domain protein FOC74_27145 ENOG4105EN6 Membrane FOC74_27150 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC74_27155 ENOG4105CXI aluminum resistance protein FOC74_27160 ENOG4105KV4 Transcriptional regulator FOC74_27165 ENOG4105C5F glutamine synthetase FOC74_27195 ENOG4105K7K Transcriptional regulator FOC74_27215 ENOG4108SVB resolvase FOC74_27225 ENOG4105CGH 5'-nucleotidase FOC74_27235 ENOG4105D5T phosphonate abc transporter FOC74_27250 ENOG4105D7V transposase FOC74_27270 ENOG4105BZ1 (ABC) transporter FOC74_27275 ENOG4105BZ1 (ABC) transporter FOC74_27290 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC74_27315 ENOG41067MG lrgb family FOC74_27325 ENOG4107RSM transcriptional regulator FOC74_27335 ENOG4105CJ1 ABC, transporter FOC74_27355 ENOG4107QIV Cytochrome c biogenesis protein FOC74_27420 ENOG4108903 Formimidoylglutamase FOC74_27425 ENOG4108VJ1 Transcriptional regulator (CarD family FOC74_27430 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC74_27435 ENOG4105CBC glutamate synthase FOC74_27440 ENOG4105CK7 Sodium proline symporter FOC74_27445 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FOC74_27450 ENOG4105FBA Phospholipase Carboxylesterase FOC74_27455 ENOG4105BZU Histidine kinase FOC74_27465 ENOG4107AYK membrAne FOC74_27520 ENOG4105CEY Amp-dependent synthetase and ligase FOC74_27525 ENOG4107ZYJ bioY protein FOC74_27530 ENOG4107F3J Amp-dependent synthetase and ligase FOC74_27550 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC74_27590 ENOG4108I0Z Aconitate hydratase FOC74_27595 ENOG4108JJA ABC, transporter FOC74_27605 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC74_27610 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC74_27640 ENOG4105W8X HesB YadR YfhF-family protein FOC74_27650 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOC74_27660 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC74_27665 ENOG4105C0H protease FOC74_27670 ENOG4105K4P CoA-binding domain protein FOC74_27675 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC74_27685 ENOG4105D9R oxidoreductase FOC74_27695 ENOG4105CIG ABC transporter FOC74_27715 ENOG4105EMN RNA polymerase sigma factor FOC74_27725 ENOG4108KGH TRANSCRIPTIONal FOC74_27730 ENOG4107QJT sodium dicarboxylate symporter FOC74_27795 ENOG4105E1K spore germination protein FOC74_27800 ENOG4108JB9 formate dehydrogenase FOC74_27810 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FOC74_27815 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC74_27825 ENOG4105TMB Formate nitrite transporter FOC74_27830 ENOG4105D06 uba thif-type nad fad binding protein FOC74_27835 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC74_27840 ENOG4108ZAF Molybdopterin FOC74_27850 ENOG4105D1F ATP-binding protein FOC74_27870 ENOG4105FR1 rard protein FOC74_27880 ENOG4105EWU Squalene--hopene cyclase FOC74_27890 ENOG4105CHR reductase FOC74_27895 ENOG4105C26 Dehydrogenase FOC74_27905 ENOG4108IA2 Sodium pantothenate symporter FOC74_27920 ENOG4106IQC argininosuccinate lyase FOC74_27930 ENOG410904N short-chain dehydrogenase reductase FOC74_27950 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOC74_27970 ENOG4105VEQ Cold shock protein FOC74_27990 ENOG4108R1P FOC74_28000 ENOG41073R8 VanW family FOC74_28005 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC74_28020 ENOG4105KT7 mgtC SapB transporter FOC74_28030 ENOG4105E39 Enoyl-CoA hydratase FOC74_28035 ENOG4105K64 Glycosyl transferase, family 2 FOC74_28045 ENOG4108UT6 Transferase hexapeptide repeat containing protein FOC74_28075 ENOG4105C09 Bile acid FOC74_28085 ENOG4105RHY Pfam:UPF0157 FOC74_28110 ENOG4105CIS alcohol dehydrogenase FOC74_28115 ENOG41082BM Transcriptional regulator, arsr family FOC74_28140 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC74_28170 ENOG4108A04 Beta-lactamase FOC74_28175 ENOG4105DPN Oligoendopeptidase f FOC74_28180 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FOC74_28185 ENOG4105E5K Alpha-amylase FOC74_28195 ENOG4105C98 muts2 protein FOC74_28215 ENOG4107V2S Transcriptional regulator FOC74_28225 ENOG4107CUJ Protein of unknown function (DUF2690) FOC74_28250 ENOG4107ZY0 Phenazine biosynthesis-like protein FOC74_28255 ENOG4105NX3 Membrane FOC74_28260 ENOG4105DQ5 transport system permease protein FOC74_28265 ENOG4105EHG Permease protein FOC74_28270 ENOG4108MES Periplasmic binding protein FOC74_28285 ENOG4107R3E Citrate transporter FOC74_28295 ENOG4108TN2 lmbE family FOC74_28330 ENOG4105CIS alcohol dehydrogenase FOC74_28365 ENOG4105H3G oxidoreductase FOC74_28415 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FOC74_28440 ENOG4105KAF membrAne FOC74_28495 ENOG4105KVH Transcriptional regulator FOC74_28500 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FOC74_28510 ENOG4105KNA -acetyltransferase FOC74_28520 ENOG4105CHR reductase FOC74_28530 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC74_28565 ENOG4105KVH Transcriptional regulator FOC74_28570 ENOG4105KVH Transcriptional regulator FOC74_28575 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FOC74_28580 ENOG4105D9R oxidoreductase FOC74_28585 ENOG4108TZY GntR Family Transcriptional Regulator FOC74_28625 ENOG4105C44 Serine transporter FOC74_28660 ENOG4105D4Y metalloprotease FOC74_28665 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FOC74_28685 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FOC74_28700 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC74_28715 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC74_28720 ENOG4105C6Z Gluconate FOC74_28725 ENOG4105CMG Carbohydrate kinase FOC74_28730 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOC74_28735 ENOG4105XDF Protein of unknown function (DUF1272) FOC74_28740 ENOG4105DDN Pentapeptide repeat-containing protein FOC74_28755 ENOG4105C37 (CBS) domain FOC74_28785 ENOG4105EV4 Multidrug resistance protein mdtH FOC74_28795 ENOG4105DMQ Methyltransferase FOC74_28835 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC74_28845 ENOG4108UW5 maltose o-acetyltransferase FOC74_28850 ENOG4106UW1 Major Facilitator superfamily FOC74_28855 ENOG4105DKQ ROK family FOC74_28860 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FOC74_28920 ENOG4105CJ1 ABC, transporter FOC74_28930 ENOG4108PSK reductase FOC74_28950 ENOG4108RCM Nitroreductase FOC74_28955 ENOG4105KVH Transcriptional regulator FOC74_28975 ENOG4108Z66 YbaK ebsC protein FOC74_28980 ENOG4105EKQ RNA-directed DNA polymerase FOC74_28985 ENOG4108Z4K mutator MutT protein FOC74_28990 ENOG4105K59 histidine triad (HIT) protein FOC74_28995 ENOG4105EKQ RNA-directed DNA polymerase FOC74_29010 ENOG4108IND Tetr family transcriptional regulator FOC74_29015 ENOG4105EQ0 Major Facilitator superfamily FOC74_29050 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC74_29085 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC74_29095 ENOG4105CRW Short chain fatty acid transporter FOC74_29105 ENOG4105KBX Transcriptional regulator, TetR family FOC74_29110 ENOG4105KPY Small multidrug resistance protein FOC74_29115 ENOG4105RXJ FOC74_29125 ENOG4105CZM Major Facilitator FOC74_29130 ENOG4107MII Sugar-specific transcriptional regulator TrmB FOC74_29140 ENOG4108ISG Major Facilitator