locus-tag class description FOC75_00035 ENOG41060SN FOC75_00065 ENOG4106CGH Phage Mu protein F like protein FOC75_00070 ENOG4108MDF Phage Portal Protein FOC75_00110 ENOG4105QBX endodeoxyribonuclease RusA FOC75_00210 ENOG4105CDU Replicative dna helicase FOC75_00230 ENOG4108PNI recT protein FOC75_00235 ENOG4108NF7 phage-type endonuclease FOC75_00295 ENOG4107QJE Chromosome Partitioning Protein FOC75_00335 ENOG4105PKS Excinuclease abc c subunit domain protein FOC75_00350 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC75_00395 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC75_00400 ENOG4105ECP epimerase FOC75_00430 ENOG41067AE Membrane-bound metal-dependent hydrolase FOC75_00435 ENOG4105CEN a g-specific adenine glycosylase FOC75_00440 ENOG4106BXE FOC75_00460 ENOG4105BZ1 (ABC) transporter FOC75_00465 ENOG4107NBY Membrane FOC75_00470 ENOG4105CBC glutamate synthase FOC75_00480 ENOG4108IUW ABC transporter FOC75_00500 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC75_00505 ENOG4105G5W regulator Fur family FOC75_00620 ENOG4108JQC penicillin-binding protein 1A FOC75_00625 ENOG4107ZQN disulfide bond FOC75_00635 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOC75_00645 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOC75_00650 ENOG4105BZU Histidine kinase FOC75_00655 ENOG4105CYN Serine protein kinase FOC75_00685 ENOG4108IMY Transcriptional regulator FOC75_00720 ENOG4105CDU Replicative dna helicase FOC75_00745 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FOC75_00790 ENOG410682Q Phage transcriptional regulator, ArpU FOC75_00820 ENOG4105CAR Terminase, large subunit FOC75_00920 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FOC75_00950 ENOG4105C94 Transporter FOC75_00965 ENOG4105DZ6 Band 7 protein FOC75_00975 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOC75_00980 ENOG4108V9W transcriptional regulatory protein FOC75_00985 ENOG4105D4T Citrate transporter FOC75_01005 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC75_01010 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC75_01015 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOC75_01020 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FOC75_01025 ENOG4105BZ7 extracellular solute-binding protein family 1 FOC75_01030 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOC75_01035 ENOG4108STX response regulator FOC75_01040 ENOG4105US7 Histidine kinase FOC75_01065 ENOG4108MRH transcriptional regulatory protein FOC75_01075 ENOG4105C6K Malic enzyme FOC75_01085 ENOG4108UZ3 Transporter FOC75_01090 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC75_01100 ENOG4105BZU Histidine kinase FOC75_01105 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC75_01110 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC75_01115 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC75_01120 ENOG4108JB9 formate dehydrogenase FOC75_01140 ENOG4105CUB amino acid FOC75_01150 ENOG4105C59 p-type ATPase FOC75_01155 ENOG4105DAP Nicotinate phosphoribosyltransferase FOC75_01190 ENOG41073R8 VanW family FOC75_01195 ENOG4108KGH TRANSCRIPTIONal FOC75_01200 ENOG4105D9N nucleoside FOC75_01205 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOC75_01210 ENOG4105C37 (CBS) domain FOC75_01215 ENOG4108IJ0 Aspartate ammonia-lyase FOC75_01220 ENOG4105DAA L-lactate FOC75_01235 ENOG4105DUX Transporter FOC75_01240 ENOG4108MES Periplasmic binding protein FOC75_01245 ENOG4105DQ5 transport system permease protein FOC75_01250 ENOG4108IHU transport system permease protein FOC75_01255 ENOG4105E0A ABC, transporter FOC75_01270 ENOG4105EXW epimerase dehydratase FOC75_01280 ENOG4107T89 von Willebrand factor, type A FOC75_01285 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FOC75_01290 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC75_01305 ENOG4105BZU Histidine kinase FOC75_01310 ENOG4105D5Q Arginine ornithine antiporter FOC75_01315 ENOG4107414 GntR family transcriptional regulator FOC75_01320 ENOG4105C5Y PTS System FOC75_01325 ENOG4105CG3 alpha amylase, catalytic region FOC75_01340 ENOG4105E1K spore germination protein FOC75_01350 ENOG4105CRN Aminoglycoside phosphotransferase FOC75_01355 ENOG4105BZG amino acid carrier protein FOC75_01360 ENOG4105CDA abc transporter atp-binding protein FOC75_01365 ENOG4105CT1 (ABC) transporter FOC75_01370 ENOG4105EAD ABC transporter FOC75_01375 ENOG4105DRP amino acid AbC transporter FOC75_01380 ENOG4108IQI permease FOC75_01395 ENOG4105GFR rna polymerase sigma factor FOC75_01405 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC75_01410 ENOG4105NAE bifunctional deaminase-reductase domain protein FOC75_01415 ENOG4105BZU Histidine kinase FOC75_01420 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC75_01430 ENOG4105CHH sulfate transporter FOC75_01435 ENOG41068KF Universal stress protein FOC75_01445 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC75_01455 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC75_01460 ENOG4108JQ7 (ABC) transporter FOC75_01470 ENOG4105CXY transporter FOC75_01475 ENOG41067TZ transcriptional regulator, MarR family FOC75_01480 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC75_01485 ENOG4105ETE Transcriptional regulator (LacI family FOC75_01490 ENOG4108RVA ribokinase FOC75_01505 ENOG4105CNN ABC, transporter FOC75_01510 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOC75_01575 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC75_01580 ENOG41069ER domain protein FOC75_01585 ENOG4105VZ8 Transcriptional regulator FOC75_01590 ENOG4107D63 FOC75_01600 ENOG4105DUX Transporter FOC75_01620 ENOG4105C85 amino acid FOC75_01625 ENOG4105C7N Xanthine uracil vitamin C permease FOC75_01640 ENOG4105MA6 gCN5-related N-acetyltransferase FOC75_01665 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC75_01670 ENOG4105E2S oxidase) subunit II FOC75_01675 ENOG4108IQI permease FOC75_01690 ENOG4106CAD Protein of unknown function (DUF3311) FOC75_01695 ENOG4105E1V na solute symporter FOC75_01710 ENOG4108NHD germination protein FOC75_01715 ENOG4105CE1 Ferrous iron transport protein b FOC75_01720 ENOG4105CE1 Ferrous iron transport protein b FOC75_01725 ENOG4105CE1 Ferrous iron transport protein b FOC75_01730 ENOG4105CVA phosphate FOC75_01735 ENOG4105C8U phosphate abc transporter FOC75_01740 ENOG4105E2Z phosphate ABC transporter (Permease FOC75_01865 ENOG41080XQ Signal transduction protein with cbs domains FOC75_01885 ENOG4105ETU transcriptional activator (TenA FOC75_01895 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC75_01905 ENOG4108VEU Thiamine monophosphate synthase FOC75_01910 ENOG41080HI glycine oxidase FOC75_01925 ENOG4105D06 uba thif-type nad fad binding protein FOC75_01930 ENOG4105DWF phosphomethylpyrimidine kinase FOC75_01980 ENOG4108INS Transcriptional regulator FOC75_01995 ENOG4105C7N Xanthine uracil vitamin C permease FOC75_02005 ENOG4108PXI ErfK YbiS YcfS YnhG FOC75_02040 ENOG4108B31 Spore germination protein FOC75_02060 ENOG4107Y03 Nitroreductase FOC75_02065 ENOG4105ED1 spovr family FOC75_02075 ENOG4108TCS Glutamyl endopeptidase FOC75_02085 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FOC75_02090 ENOG4105XTG Pfam:DUF156 FOC75_02095 ENOG4105VFE sira family FOC75_02100 ENOG4107TPS domain protein FOC75_02105 ENOG4105VFE sira family FOC75_02110 ENOG41085GJ domain protein FOC75_02120 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FOC75_02125 ENOG41087NI Sulfite exporter TauE/SafE FOC75_02135 ENOG4108KGH TRANSCRIPTIONal FOC75_02160 ENOG4105EMD TRANSCRIPTIONal FOC75_02165 ENOG4105VCP PTS System FOC75_02170 ENOG4105VZJ PTS System FOC75_02190 ENOG41069ER domain protein FOC75_02195 ENOG4107RBB ABC transporter, permease FOC75_02200 ENOG4105C19 ABC transporter FOC75_02230 ENOG4105WEF catalase FOC75_02265 ENOG4107T5V SNARE associated Golgi FOC75_02300 ENOG4105CUB amino acid FOC75_02305 ENOG4107RWR Sodium hydrogen exchanger FOC75_02315 ENOG4106KNT transcriptional regulator FOC75_02355 ENOG4108YXU transcriptional regulator AsnC family FOC75_02370 ENOG4105KPY Small multidrug resistance protein FOC75_02395 ENOG4105NF4 modulator of drug activity FOC75_02405 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC75_02410 ENOG4105E5W Transporter FOC75_02420 ENOG4107RKG DJ-1/PfpI family FOC75_02425 ENOG4105CH6 catalase FOC75_02435 ENOG4105D5Q Arginine ornithine antiporter FOC75_02440 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOC75_02450 ENOG4105C26 Dehydrogenase FOC75_02455 ENOG4105BZ1 (ABC) transporter FOC75_02460 ENOG4105BZ1 (ABC) transporter FOC75_02470 ENOG4105DRP amino acid AbC transporter FOC75_02475 ENOG4105CDA abc transporter atp-binding protein FOC75_02490 ENOG410839P FOC75_02525 ENOG4107FQX Alpha-acetolactate decarboxylase FOC75_02545 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC75_02550 ENOG4105D4P Coproporphyrinogen iii oxidase FOC75_02565 ENOG4105CHH sulfate transporter FOC75_02615 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC75_02620 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC75_02635 ENOG4105CGU Enoyl-CoA hydratase FOC75_02655 ENOG4105DER m42 family FOC75_02675 ENOG4105CTU Proline racemase FOC75_02720 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC75_02730 ENOG4108JQ7 (ABC) transporter FOC75_02745 ENOG4105CSH Transporter FOC75_02755 ENOG4108MRH transcriptional regulatory protein FOC75_02765 ENOG4105M6F mutator MutT protein FOC75_02825 ENOG4105CDU Replicative dna helicase FOC75_02845 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC75_02920 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC75_02950 ENOG4105CMT Dihydroxyacetone kinase FOC75_02960 ENOG4105CMT Dihydroxyacetone kinase FOC75_02975 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOC75_03040 ENOG4105WN5 stage II sporulation protein FOC75_03050 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC75_03060 ENOG4108MJI response regulator FOC75_03065 ENOG4105BZU Histidine kinase FOC75_03070 ENOG4105BZU Histidine kinase FOC75_03130 ENOG4107VRP DNA repair exonuclease FOC75_03135 ENOG4106D4I domain protein FOC75_03190 ENOG4108MUZ hydrolase FOC75_03210 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC75_03225 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOC75_03240 ENOG4105EMN RNA polymerase sigma factor FOC75_03250 ENOG4105CNI cell division protein FtsW FOC75_03265 ENOG4105C57 major facilitator superfamily FOC75_03270 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC75_03280 ENOG4105EEM helicase FOC75_03285 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC75_03310 ENOG4105K59 histidine triad (HIT) protein FOC75_03385 ENOG410905X membrane-flanked domain protein FOC75_03390 ENOG4105CKV Membrane FOC75_03430 ENOG410905X membrane-flanked domain protein FOC75_03435 ENOG4105CKV Membrane FOC75_03440 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FOC75_03445 ENOG4105BZ4 penicillin-binding protein FOC75_03460 ENOG4105C1Q protoporphyrinogen oxidase FOC75_03495 ENOG4105ECB domain protein FOC75_03515 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) FOC75_03525 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC75_03535 ENOG4106AXD FOC75_03540 ENOG4108RQ5 Beta-lactamase domain-containing protein FOC75_03545 ENOG4105DF9 Lipoate-protein, ligase FOC75_03555 ENOG4105CEY Amp-dependent synthetase and ligase FOC75_03600 ENOG4105CNA YD repeat protein FOC75_03615 ENOG4105CNA YD repeat protein FOC75_03655 ENOG4107RN3 metallophosphoesterase FOC75_03665 ENOG4107TVP HD domain protein FOC75_03675 ENOG4108AEY RNA polymerase sigma factor FOC75_03680 ENOG41086D8 Transcriptional regulator FOC75_03700 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC75_03725 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FOC75_03750 ENOG4107QP3 malate synthase g FOC75_03780 ENOG4105XVF Competence transcription factor FOC75_03845 ENOG4105ERH Fumarylacetoacetate hydrolase FOC75_03870 ENOG4105CAQ asparagine synthetase FOC75_03875 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC75_03880 ENOG4105CH6 catalase FOC75_03885 ENOG4105BZU Histidine kinase FOC75_03905 ENOG4105QNR S1 RNA binding domain protein FOC75_03915 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC75_03925 ENOG4107AYK membrAne FOC75_03930 ENOG41073B9 FOC75_03940 ENOG4108KP7 hydrolase FOC75_03950 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC75_03975 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC75_03980 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC75_03995 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC75_04010 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC75_04015 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC75_04025 ENOG4108JQ7 (ABC) transporter FOC75_04030 ENOG4105UQX Mate efflux family protein FOC75_04050 ENOG4108ZCF integral membrane protein FOC75_04060 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC75_04070 ENOG4105DPN Oligoendopeptidase f FOC75_04085 ENOG4108Z18 K06886 hemoglobin FOC75_04090 ENOG4105MIX Adenylate cyclase FOC75_04105 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FOC75_04110 ENOG4105EMS pseudouridine synthase FOC75_04130 ENOG4105K64 Glycosyl transferase, family 2 FOC75_04150 ENOG4107TVC Glycosyl transferase, family 2 FOC75_04170 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOC75_04175 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC75_04185 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOC75_04260 ENOG4105CK7 Sodium proline symporter FOC75_04270 ENOG4105DDQ anthranilate synthase FOC75_04375 ENOG4105C7S Dehydrogenase FOC75_04385 ENOG4105VZ8 Transcriptional regulator FOC75_04485 ENOG4108NE4 FOC75_04520 ENOG4105EFC phage portal protein HK97 family FOC75_04540 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC75_04555 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FOC75_04565 ENOG4105DZ1 carboxypeptidase FOC75_04570 ENOG4105VFR signal peptidase FOC75_04605 ENOG4105C26 Dehydrogenase FOC75_04615 ENOG4105F38 ABC transporter, permease FOC75_04620 ENOG4105D38 putrescine abc transporter FOC75_04625 ENOG4107RUE extracellular solute-binding protein family 1 FOC75_04635 ENOG4105EYF MMPL domain protein FOC75_04645 ENOG4108YBP pseudouridine synthase FOC75_04655 ENOG4105K4I Scp-like extracellular FOC75_04660 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOC75_04665 ENOG4105CQB FAD linked oxidase domain protein FOC75_04680 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC75_04685 ENOG4105BZU Histidine kinase FOC75_04690 ENOG4105JXH GntR family transcriptional regulator FOC75_04710 ENOG4106A3R peptidase FOC75_04720 ENOG4108QTI )-transporter FOC75_04725 ENOG4107TS3 membrane protein, TerC FOC75_04730 ENOG4105CZN Potassium uptake protein FOC75_04735 ENOG410681C small acid-soluble spore protein FOC75_04740 ENOG4108Z7G MaoC domain protein dehydratase FOC75_04760 ENOG4105CHR reductase FOC75_04770 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC75_04790 ENOG4105C4Y ABC transporter FOC75_04795 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC75_04800 ENOG4107RCV ABC transporter, permease FOC75_04820 ENOG4105E98 transcriptional regulator DeoR family FOC75_04830 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FOC75_04840 ENOG4105PXI polysaccharide deacetylase FOC75_04850 ENOG4105BZU Histidine kinase FOC75_04855 ENOG41090MY MarR family Transcriptional regulator FOC75_04865 ENOG4106DF1 FOC75_04870 ENOG4105BZU Histidine kinase FOC75_04880 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FOC75_04885 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOC75_04925 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOC75_04945 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC75_04950 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC75_04955 ENOG4105CZV ABC transporter FOC75_04965 ENOG4105CJ1 ABC, transporter FOC75_05005 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC75_05010 ENOG4105EA8 2-Nitropropane dioxygenase FOC75_05015 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC75_05025 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC75_05050 ENOG4105NQC Flavodoxin FOC75_05085 ENOG4107QMU Mate efflux family protein FOC75_05090 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC75_05120 ENOG4105CZN Potassium uptake protein FOC75_05125 ENOG41063Y9 FOC75_05130 ENOG4105KBJ sporulation protein ytfj FOC75_05150 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC75_05155 ENOG4105C7K acetolactate synthase FOC75_05160 ENOG4108ZP8 Acetolactate synthase small subunit FOC75_05235 ENOG4107RVV histidinol phosphate phosphatase, hisj family FOC75_05250 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC75_05255 ENOG4105E0M Sulfatase FOC75_05265 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOC75_05285 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FOC75_05290 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FOC75_05300 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC75_05305 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC75_05310 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC75_05315 ENOG4105C8J )-transporter FOC75_05335 ENOG4105DFD Na H antiporter FOC75_05355 ENOG4105ENE Histidine kinase FOC75_05360 ENOG4105WH1 Two component transcriptional regulator luxr family FOC75_05380 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOC75_05425 ENOG4105CJ3 phosphate transporter FOC75_05430 ENOG4107GRR phosphate transport regulator FOC75_05435 ENOG4105BZ4 penicillin-binding protein FOC75_05450 ENOG4105BZU Histidine kinase FOC75_05455 ENOG4105I3N Conserved Protein FOC75_05470 ENOG4105BZU Histidine kinase FOC75_05505 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC75_05510 ENOG4105DZ1 carboxypeptidase FOC75_05515 ENOG4108JIC nucleoside recognition domain protein FOC75_05525 ENOG4105FE9 pseudouridine synthase FOC75_05535 ENOG4107TWT Cytochrome c biogenesis protein FOC75_05540 ENOG4105CRE cytochrome C FOC75_05545 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC75_05550 ENOG4105BZU Histidine kinase FOC75_05555 ENOG4108WBT adenosyltransferase FOC75_05560 ENOG41063SB peptidase FOC75_05570 ENOG4108SAX Membrane FOC75_05585 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC75_05590 ENOG4105I7S Abortive infection protein FOC75_05600 ENOG4107RGJ metallophosphoesterase FOC75_05605 ENOG4107X2D transcriptional regulator, merr family FOC75_05610 ENOG4108S6Z Negative regulator of genetic competence FOC75_05635 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FOC75_05640 ENOG4105HDK L-asparaginase FOC75_05675 ENOG4105S2F FOC75_05680 ENOG41065D1 FOC75_05710 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FOC75_05725 ENOG4105XXQ heptaprenyl diphosphate synthase component I FOC75_05735 ENOG4105EAH synthase FOC75_05755 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC75_05760 ENOG41068YB TPR repeat-containing protein FOC75_05775 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FOC75_05780 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOC75_05785 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit FOC75_05815 ENOG4108JYZ YitT family FOC75_05820 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FOC75_05835 ENOG4105FJR Lmbe family FOC75_05840 ENOG4105CPK Glycosyl transferase (Group 1 FOC75_05875 ENOG4105DVT helicase FOC75_05880 ENOG4105YAC FOC75_05900 ENOG4105CSM endonuclease III FOC75_05910 ENOG4105BZ4 penicillin-binding protein FOC75_05970 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOC75_05980 ENOG4105DVT helicase FOC75_05985 ENOG4105CTD carboxy-peptidase FOC75_06000 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC75_06010 ENOG4105C2W permease FOC75_06015 ENOG4105DHF Membrane FOC75_06020 ENOG410890F Dynamin family FOC75_06030 ENOG4108W0I acetyltransferase FOC75_06040 ENOG4105KHC sulfurtransferase FOC75_06065 ENOG4106032 Glutathionylspermidine synthase FOC75_06125 ENOG4105CPK Glycosyl transferase (Group 1 FOC75_06140 ENOG4108SZE gCN5-related N-acetyltransferase FOC75_06160 ENOG41081VK Ribonuclease FOC75_06225 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC75_06235 ENOG4107RWR Sodium hydrogen exchanger FOC75_06240 ENOG4105CN5 Metallo-Beta-Lactamase FOC75_06245 ENOG4108Z5V transcriptional regulator, merr family FOC75_06255 ENOG4105H67 Protein of unknown function (DUF421) FOC75_06260 ENOG41080C8 DUF218 domain FOC75_06315 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC75_06325 ENOG4107R0U MotA TolQ exbB proton channel FOC75_06330 ENOG4105ER2 Ompa motb domain protein FOC75_06335 ENOG4107YTP response regulator receiver protein FOC75_06340 ENOG4105CBS Chea signal transduction histidine kinase FOC75_06345 ENOG4105DD5 Flagellar motor switch protein FOC75_06360 ENOG4105BZU Histidine kinase FOC75_06380 ENOG4105E1Q flagellar hook-associated protein FOC75_06385 ENOG4105DTJ flagellar hook-associated protein FOC75_06390 ENOG4107TPX flagellar hook-associated FOC75_06405 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOC75_06410 ENOG4108ZC9 flagellar basal-body rod protein flgc FOC75_06420 ENOG4107U2N Flagellar M-ring protein FOC75_06425 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC75_06455 ENOG4105BZE flagellar hook protein, FlgE FOC75_06470 ENOG4107R88 Chemotaxis protein (CheV) FOC75_06480 ENOG4105I03 Flagellin FOC75_06485 ENOG4105I03 Flagellin FOC75_06490 ENOG4105E4C Lytic transglycosylase catalytic FOC75_06500 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC75_06505 ENOG4105DD5 Flagellar motor switch protein FOC75_06515 ENOG4105CN7 Flagellar biosynthetic protein FliP FOC75_06520 ENOG4105VS8 Flagellar biosynthetic protein fliq FOC75_06530 ENOG4105D00 flagellar biosynthetic protein flhB FOC75_06535 ENOG4105D7B Flagellar biosynthesis protein flha FOC75_06540 ENOG4105FZW flagellar biosynthesis regulator FlhF FOC75_06545 ENOG4105KTQ flagellar basal-body rod protein FOC75_06550 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC75_06585 ENOG4105KAC Antibiotic biosynthesis monooxygenase FOC75_06615 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC75_06625 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FOC75_06630 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOC75_06670 ENOG4105CVJ phosphoglycerate mutase FOC75_06690 ENOG4105K56 Transcriptional regulator FOC75_06700 ENOG4105CAQ asparagine synthetase FOC75_06720 ENOG4105PGM cation diffusion facilitator family transporter FOC75_06730 ENOG4105DRR Transcriptional regulator, GntR family FOC75_06735 ENOG4108UZ3 Transporter FOC75_06740 ENOG4105CKI cobalamin synthesis protein FOC75_06745 ENOG4108PJD permease FOC75_06760 ENOG4105DFD Na H antiporter FOC75_06765 ENOG4105VUF Transcriptional regulator FOC75_06775 ENOG4105C9Q fumarate hydratase class II FOC75_06795 ENOG4107QJQ Mate efflux family protein FOC75_06800 ENOG4105EC3 peptidase S51, dipeptidase E FOC75_06820 ENOG4107QIV Cytochrome c biogenesis protein FOC75_06850 ENOG4106BRA Membrane FOC75_06885 ENOG4105CJ1 ABC, transporter FOC75_06905 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC75_06915 ENOG4108IJ0 Aspartate ammonia-lyase FOC75_06920 ENOG4105C6K Malic enzyme FOC75_06985 ENOG4105FVX FOC75_07025 ENOG4105CSR polyphosphate kinase 2 FOC75_07030 ENOG4105DXI Major Facilitator superfamily FOC75_07045 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC75_07055 ENOG4105EU0 Major facilitator Superfamily FOC75_07060 ENOG4105C6T cysteine synthase FOC75_07080 ENOG4105C8J )-transporter FOC75_07090 ENOG4105X5K response regulator receiver protein FOC75_07095 ENOG4105H67 Protein of unknown function (DUF421) FOC75_07110 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC75_07115 ENOG4105CHR reductase FOC75_07120 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC75_07125 ENOG4105C7K acetolactate synthase FOC75_07130 ENOG4108ZP8 Acetolactate synthase small subunit FOC75_07135 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC75_07145 ENOG4105C7B Threonine dehydratase FOC75_07170 ENOG4105C6X Major Facilitator FOC75_07175 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FOC75_07185 ENOG4105DY9 regulatoR FOC75_07190 ENOG4105CYC Transferase FOC75_07240 ENOG41068WN FOC75_07260 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOC75_07275 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOC75_07280 ENOG4105C0X amino acid FOC75_07305 ENOG4107RHR regulatoR FOC75_07315 ENOG4105D9N nucleoside FOC75_07320 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FOC75_07355 ENOG4107RAQ aminopeptidase FOC75_07360 ENOG4107R16 Multicopper oxidase FOC75_07405 ENOG4108T5E Copper resistance protein FOC75_07410 ENOG4105KTB nuclear export factor GLE1 FOC75_07415 ENOG4107RT3 EamA-like transporter family FOC75_07420 ENOG4105GZI Transcriptional regulator FOC75_07425 ENOG4108Z40 Transcriptional regulator FOC75_07430 ENOG4107ZXU DSBA oxidoreductase FOC75_07435 ENOG4108TVJ Nitroreductase FOC75_07445 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC75_07450 ENOG4106F5Q Membrane FOC75_07465 ENOG4105CKI cobalamin synthesis protein FOC75_07485 ENOG4108Z7G MaoC domain protein dehydratase FOC75_07490 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC75_07500 ENOG4105C0Z ABC transporter FOC75_07505 ENOG4108IV0 ABC, transporter FOC75_07510 ENOG4105C32 Amino acid ABC transporter (Permease) FOC75_07520 ENOG4105SKE transcriptional Regulator LysR family FOC75_07550 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC75_07555 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC75_07560 ENOG4108JJ9 ABC, transporter FOC75_07565 ENOG4108JJ8 (ABC) transporter FOC75_07610 ENOG4105BZ1 (ABC) transporter FOC75_07615 ENOG4105EFI regulatoR FOC75_07620 ENOG4105BZU Histidine kinase FOC75_07640 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FOC75_07650 ENOG4106AKJ FOC75_07665 ENOG4105D6E homoserine dehydrogenase FOC75_07690 ENOG4108KGH TRANSCRIPTIONal FOC75_07700 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC75_07705 ENOG4105BZU Histidine kinase FOC75_07720 ENOG4105KT7 mgtC SapB transporter FOC75_07725 ENOG4105VRR gCN5-related N-acetyltransferase FOC75_07735 ENOG4105DUU IucA IucC family protein FOC75_07740 ENOG4105CEY Amp-dependent synthetase and ligase FOC75_07755 ENOG4108WBH protein TIM barrel FOC75_07760 ENOG4105YWU small acid-soluble spore protein FOC75_07770 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FOC75_07820 ENOG4105KRN Transcriptional regulator, abrb family FOC75_07830 ENOG4105YVS arsR family transcriptional regulator FOC75_07835 ENOG4107SET aldo keto reductase FOC75_07840 ENOG4107XZQ multidrug resistance protein FOC75_07865 ENOG4105C8Q Methyl-accepting chemotaxis FOC75_07880 ENOG4108K88 Membrane FOC75_07885 ENOG4108WPJ Ferritin-like domain FOC75_07900 ENOG4105DEN Luciferase family FOC75_07920 ENOG4107QM2 Aldo Keto reductase FOC75_07925 ENOG4105CKI cobalamin synthesis protein FOC75_07985 ENOG4105DSE periplasmic solute binding protein FOC75_07995 ENOG4105K4T epimerase FOC75_08005 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC75_08030 ENOG4107TB6 phosphoglycerate mutase FOC75_08050 ENOG4107T5V SNARE associated Golgi FOC75_08065 ENOG4108PJD permease FOC75_08075 ENOG4108S4H thioesterase Superfamily protein FOC75_08085 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC75_08105 ENOG4105SXS Protein of unknown function (DUF456) FOC75_08110 ENOG4105C37 (CBS) domain FOC75_08130 ENOG4108Z7R Chaperone CsaA FOC75_08150 ENOG4108ZRV stage ii sporulation protein p FOC75_08160 ENOG4108VXD carboxy-peptidase FOC75_08170 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC75_08195 ENOG4108X4Q Hydrolase FOC75_08205 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC75_08225 ENOG41087PP glycosyltransferase MGT family FOC75_08230 ENOG4108JYZ YitT family FOC75_08235 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC75_08265 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC75_08325 ENOG4105EKQ RNA-directed DNA polymerase FOC75_08335 ENOG4105KBJ sporulation protein ytfj FOC75_08360 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC75_08385 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FOC75_08395 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FOC75_08400 ENOG4105EMN RNA polymerase sigma factor FOC75_08415 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) FOC75_08435 ENOG4108V06 Glutathione peroxidase FOC75_08450 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC75_08460 ENOG4108IUE nitrate reductase beta subunit FOC75_08465 ENOG4105R3A Nitrate reductase FOC75_08480 ENOG4108Z40 Transcriptional regulator FOC75_08485 ENOG4105K63 Thioredoxin FOC75_08490 ENOG4107QN2 dihydrolipoyl dehydrogenase FOC75_08495 ENOG4106HZJ FOC75_08500 ENOG4108X3M OsmC Ohr family protein FOC75_08505 ENOG4105D3W isochorismatase FOC75_08515 ENOG4107V6Q Cyclic nucleotide-binding domain FOC75_08520 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC75_08525 ENOG4105D06 uba thif-type nad fad binding protein FOC75_08530 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC75_08535 ENOG4108ZAF Molybdopterin FOC75_08555 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC75_08560 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC75_08565 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC75_08570 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOC75_08575 ENOG4108IFG nitrite reductase, (NAD(P)H) FOC75_08580 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FOC75_08615 ENOG4105MCT stage V sporulation protein S FOC75_08645 ENOG4105C5H ABC transporter FOC75_08660 ENOG4108UUM single-stranded DNA-binding protein FOC75_08665 ENOG4105EKQ RNA-directed DNA polymerase FOC75_08690 ENOG4105EKQ RNA-directed DNA polymerase FOC75_08700 ENOG4105C75 arginyL-tRNA synthetase FOC75_08720 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FOC75_08740 ENOG4105C5S asparaginyl-tRNA synthetase FOC75_08760 ENOG4105EC2 ftsk spoIIIe FOC75_08805 ENOG4105BZW Glycerate kinase FOC75_08810 ENOG4107QPK )-transporter FOC75_08815 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC75_08820 ENOG41062D9 Histidine kinase FOC75_08835 ENOG4105C8J )-transporter FOC75_08855 ENOG4107XGZ Hydrolase FOC75_08860 ENOG4105CY2 Citrate transporter FOC75_08880 ENOG4105KD7 acetyltransferase FOC75_08885 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FOC75_08910 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FOC75_08930 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FOC75_08945 ENOG4107RVG penicillin-binding protein FOC75_08955 ENOG4105E9Q Acyl-transferase FOC75_08960 ENOG4108UT2 hemolysin iii FOC75_08970 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOC75_08980 ENOG4108RCR degv family FOC75_08985 ENOG4105E8R UPF0173 metal-dependent hydrolase FOC75_08990 ENOG4108KF3 Electron transport protein SCO1 SenC FOC75_08995 ENOG4107Y70 Heat shock protein FOC75_09000 ENOG4105CAQ asparagine synthetase FOC75_09015 ENOG4108MES Periplasmic binding protein FOC75_09020 ENOG4105F0I Aminotransferase FOC75_09050 ENOG4107Y70 Heat shock protein FOC75_09055 ENOG4105D8X mechanosensitive ion channel FOC75_09060 ENOG4105BZU Histidine kinase FOC75_09065 ENOG4105WH1 Two component transcriptional regulator luxr family FOC75_09100 ENOG4105CMG Carbohydrate kinase FOC75_09105 ENOG4105CMG Carbohydrate kinase FOC75_09135 ENOG4108IJ8 ABC transporter FOC75_09140 ENOG4105E90 ABC transporter FOC75_09175 ENOG4105C37 (CBS) domain FOC75_09200 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC75_09215 ENOG4107S4Y M20 DapE family protein YgeY FOC75_09220 ENOG4108TSC N-acetyltransferase FOC75_09225 ENOG4108JUB Transcriptional regulator FOC75_09230 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FOC75_09270 ENOG4108N23 SpoOM-related protein FOC75_09275 ENOG410841Q phosphoesterase PA-phosphatase related protein FOC75_09285 ENOG4105SZ6 Thioredoxin FOC75_09300 ENOG4108IBT Inherit from COG: transposase FOC75_09405 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC75_09445 ENOG4105BZ4 penicillin-binding protein FOC75_09450 ENOG4105DP8 Major facilitator superfamily MFS_1 FOC75_09455 ENOG4105W8X HesB YadR YfhF-family protein FOC75_09465 ENOG4105DXD 2-methylcitrate dehydratase FOC75_09470 ENOG4105CR4 methylisocitrate lyase FOC75_09475 ENOG4105C1G acyl-Coa dehydrogenase FOC75_09480 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC75_09490 ENOG4105N14 lysine exporter protein LysE YggA FOC75_09495 ENOG4105E39 Enoyl-CoA hydratase FOC75_09510 ENOG4107RFY SbcCD D subunit FOC75_09515 ENOG4105EYH Exonuclease FOC75_09535 ENOG4105FCD Major Facilitator FOC75_09540 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FOC75_09545 ENOG4105E4F Isochorismate synthase FOC75_09550 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FOC75_09555 ENOG4105WQI isochorismatase FOC75_09560 ENOG4105CEY Amp-dependent synthetase and ligase FOC75_09565 ENOG4105WQT MbtH domain protein FOC75_09570 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC75_09585 ENOG4105K70 DNA-binding protein FOC75_09605 ENOG4105BZG amino acid carrier protein FOC75_09625 ENOG4105FE9 pseudouridine synthase FOC75_09630 ENOG4105C22 threonyL-tRNA synthetase FOC75_09635 ENOG4105C19 ABC transporter FOC75_09645 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC75_09665 ENOG4108D32 Methyltransferase FOC75_09685 ENOG41081I9 integral membrane protein FOC75_09700 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC75_09710 ENOG4105EYF MMPL domain protein FOC75_09735 ENOG4105WCN acetyltransferase FOC75_09765 ENOG4105C1Q protoporphyrinogen oxidase FOC75_09775 ENOG41068WN FOC75_09785 ENOG4105VEQ Cold shock protein FOC75_09805 ENOG410667J hydrolase FOC75_09850 ENOG4107V2S Transcriptional regulator FOC75_09855 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC75_09870 ENOG4105DND Transcriptional regulator FOC75_09875 ENOG4108RPX mosc domain containing protein FOC75_09890 ENOG4105BZ1 (ABC) transporter FOC75_09895 ENOG4105BZ1 (ABC) transporter FOC75_09915 ENOG4108JCI Transcriptional regulator FOC75_09945 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC75_09955 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B FOC75_09960 ENOG4108KPJ rna polymerase sigma factor FOC75_09985 ENOG4105F32 YngK protein FOC75_10010 ENOG4105RD7 BadF BadG BcrA BcrD FOC75_10020 ENOG4107STF Involved in phosphonate degradation (By similarity) FOC75_10055 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC75_10070 ENOG4105C1J atp-dependent rna helicase FOC75_10085 ENOG4108RZE Tetr family transcriptional regulator FOC75_10105 ENOG41088CC tellurite resistance protein tehB FOC75_10120 ENOG4107RA9 decarboxylase FOC75_10125 ENOG41090HR transcriptional regulator FOC75_10160 ENOG4105CIN aminoacyl-histidine dipeptidase FOC75_10185 ENOG4107RF6 penicillin-binding protein FOC75_10190 ENOG4107RF6 penicillin-binding protein FOC75_10200 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOC75_10205 ENOG4105ETE Transcriptional regulator (LacI family FOC75_10210 ENOG4105IE8 Alpha-ketoglutarate permease FOC75_10215 ENOG4105CK5 oxidoreductase FOC75_10240 ENOG4105D2N Aldolase FOC75_10245 ENOG4105DH8 myo-inositol catabolism FOC75_10260 ENOG4105CGH 5'-nucleotidase FOC75_10275 ENOG4105VZ8 Transcriptional regulator FOC75_10290 ENOG4108VXD carboxy-peptidase FOC75_10305 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity FOC75_10310 ENOG41067SE Tetr family transcriptional regulator FOC75_10315 ENOG4105C5H ABC transporter FOC75_10320 ENOG4105BZU Histidine kinase FOC75_10345 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FOC75_10360 ENOG4105CJ1 ABC, transporter FOC75_10370 ENOG4107Z3H Transcriptional regulator, TetR family FOC75_10385 ENOG4105C1G acyl-Coa dehydrogenase FOC75_10390 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC75_10395 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FOC75_10400 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC75_10405 ENOG4105E39 Enoyl-CoA hydratase FOC75_10410 ENOG4107QX3 carboxylase FOC75_10415 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC75_10425 ENOG4105WCN acetyltransferase FOC75_10430 ENOG4105DBI uridine monophosphokinase FOC75_10445 ENOG4105DZ1 carboxypeptidase FOC75_10460 ENOG4105T9C HD domain FOC75_10470 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC75_10520 ENOG4105FQP Beta-lactamase FOC75_10530 ENOG4107Y80 Major Facilitator superfamily FOC75_10550 ENOG4105CUV Homoserine Kinase FOC75_10585 ENOG4105CPQ Dehydrogenase FOC75_10605 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FOC75_10615 ENOG4105DK7 lysyl-tRNA synthetase FOC75_10700 ENOG4105ETU transcriptional activator (TenA FOC75_10735 ENOG4105VTR Integrase FOC75_10825 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein FOC75_10975 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC75_11055 ENOG410667J hydrolase FOC75_11060 ENOG4105BZU Histidine kinase FOC75_11065 ENOG4107RF6 penicillin-binding protein FOC75_11100 ENOG4108HGU Histidine kinase FOC75_11115 ENOG4105CB2 alcohol dehydrogenase FOC75_11120 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOC75_11125 ENOG4105CJN penicillin-binding protein FOC75_11135 ENOG4105FQP Beta-lactamase FOC75_11170 ENOG4108V4B ThiJ pfpI FOC75_11200 ENOG4107Y80 Major Facilitator superfamily FOC75_11215 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC75_11235 ENOG4107Y9U Membrane FOC75_11275 ENOG4105FCD Major Facilitator FOC75_11290 ENOG4105E09 nadh pyrophosphatase FOC75_11295 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC75_11300 ENOG4108Z4K mutator MutT protein FOC75_11335 ENOG4108XI2 Domain of unknown function (DUF1963) FOC75_11355 ENOG4108NRW Phospholipase, patatin family FOC75_11360 ENOG4105KWG Pfam:DUF1696 FOC75_11395 ENOG4105PKS Excinuclease abc c subunit domain protein FOC75_11435 ENOG4107VFR oxidoreductase FOC75_11485 ENOG4105DY8 decarboxylase FOC75_11500 ENOG4108IUM Glycogen debranching enzyme FOC75_11525 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC75_11535 ENOG4105FDR Membrane FOC75_11590 ENOG4105MSI germination protein ypeb FOC75_11625 ENOG4107Z3H Transcriptional regulator, TetR family FOC75_11645 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOC75_11665 ENOG4105E98 transcriptional regulator DeoR family FOC75_11690 ENOG4107QKR Dehydrogenase FOC75_11700 ENOG4107RUY (E1 component), alpha subunit FOC75_11710 ENOG4105E1F short-chain dehydrogenase reductase FOC75_11715 ENOG4105RHY Pfam:UPF0157 FOC75_11755 ENOG4107SQ8 Glycine betaine FOC75_11760 ENOG4108IJ7 Glycine betaine FOC75_11785 ENOG4105E66 phosphoriboisomerase A FOC75_11790 ENOG41082BV acetyltransferase FOC75_11795 ENOG4108M1A Chitin-binding protein FOC75_11800 ENOG41087PP glycosyltransferase MGT family FOC75_11820 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC75_11845 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC75_11875 ENOG4108Z7F N-acetyltransferase FOC75_11895 ENOG4105EEM helicase FOC75_11915 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC75_11960 ENOG4108M1A Chitin-binding protein FOC75_11980 ENOG4105BZG amino acid carrier protein FOC75_11985 ENOG4105C26 Dehydrogenase FOC75_11990 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC75_11995 ENOG4105CTU Proline racemase FOC75_12000 ENOG4105CTU Proline racemase FOC75_12005 ENOG41080HI glycine oxidase FOC75_12015 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FOC75_12045 ENOG4107T5V SNARE associated Golgi FOC75_12060 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC75_12065 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC75_12080 ENOG4105DTQ mandelate racemase muconate lactonizing FOC75_12125 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FOC75_12130 ENOG4105BZU Histidine kinase FOC75_12135 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC75_12170 ENOG4105DPN Oligoendopeptidase f FOC75_12180 ENOG4105EPR degv family FOC75_12220 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC75_12225 ENOG4106K7D Major facilitator family transporter FOC75_12245 ENOG4107BMA Transglycosylase associated protein FOC75_12260 ENOG41089UC methyltransferase, type 11 FOC75_12300 ENOG4105CHM Aminotransferase FOC75_12315 ENOG4108ZMI UPF0477 protein FOC75_12330 ENOG4105DVE abc transporter atp-binding protein FOC75_12380 ENOG4105C02 permease FOC75_12390 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOC75_12395 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC75_12400 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FOC75_12425 ENOG4105E09 nadh pyrophosphatase FOC75_12445 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FOC75_12495 ENOG4107VC0 DNA alkylation repair enzyme FOC75_12515 ENOG4108ZCF integral membrane protein FOC75_12520 ENOG4105E0M Sulfatase FOC75_12525 ENOG4105C5H ABC transporter FOC75_12535 ENOG4105EYF MMPL domain protein FOC75_12540 ENOG41082JN Transcriptional regulator FOC75_12560 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC75_12570 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC75_12590 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) FOC75_12605 ENOG41069ER domain protein FOC75_12615 ENOG4105CY2 Citrate transporter FOC75_12620 ENOG4105E39 Enoyl-CoA hydratase FOC75_12625 ENOG4105J5T Amp-dependent synthetase and ligase FOC75_12630 ENOG4108JUB Transcriptional regulator FOC75_12645 ENOG4105D4B ABC, transporter FOC75_12655 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FOC75_12665 ENOG4105DKT Transcriptional regulator FOC75_12670 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) FOC75_12680 ENOG41061GT Aldolase FOC75_12705 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FOC75_12735 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FOC75_12740 ENOG4105II7 pyrroline-5-carboxylate reductase FOC75_12770 ENOG4107258 Transcriptional regulator FOC75_12780 ENOG4105E0Y RtcB Protein FOC75_12785 ENOG4105ECK Fatty Acid Desaturase FOC75_12790 ENOG4105G6Z alkaline phosphatase FOC75_12800 ENOG4105VMP Transcriptional regulator FOC75_12815 ENOG41090T1 Membrane FOC75_12825 ENOG4108WCX response regulator FOC75_12835 ENOG41068WN FOC75_12860 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC75_12875 ENOG4105CSH Transporter FOC75_12905 ENOG4105CKK Glycosyl transferase, family 2 FOC75_12915 ENOG4105C8Y Acetylornithine aminotransferase FOC75_12960 ENOG4108TVJ Nitroreductase FOC75_12965 ENOG4105FS7 Transcriptional regulator FOC75_12985 ENOG4105ERH Fumarylacetoacetate hydrolase FOC75_13000 ENOG41082UD thioesterase Superfamily protein FOC75_13005 ENOG4105CEY Amp-dependent synthetase and ligase FOC75_13010 ENOG4105CHU acetyl-coa acetyltransferase FOC75_13015 ENOG4105E39 Enoyl-CoA hydratase FOC75_13020 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC75_13025 ENOG4105CS2 ec 3.2.1.21 FOC75_13030 ENOG4105VCP PTS System FOC75_13035 ENOG4108QVC Component IIC FOC75_13050 ENOG4105VZJ PTS System FOC75_13060 ENOG4105G9B Transcriptional regulator FOC75_13065 ENOG4105D2S major facilitator superfamily FOC75_13070 ENOG4105EFZ amidohydrolase FOC75_13100 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC75_13110 ENOG4105C19 ABC transporter FOC75_13140 ENOG4108XET gCN5-related N-acetyltransferase FOC75_13205 ENOG410635A Membrane FOC75_13210 ENOG4105KNA -acetyltransferase FOC75_13215 ENOG4108IQI permease FOC75_13225 ENOG4105F1N DNA alkylation repair FOC75_13255 ENOG4107RF6 penicillin-binding protein FOC75_13265 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FOC75_13300 ENOG4105P4J Allophanate hydrolase, subunit 1 FOC75_13305 ENOG4107258 Transcriptional regulator FOC75_13315 ENOG4106N3A copper homeostasis protein cutc FOC75_13320 ENOG4108ZRV stage ii sporulation protein p FOC75_13325 ENOG4108ZHR arsR family transcriptional regulator FOC75_13335 ENOG4105FDT acyl-CoA dehydrogenase FOC75_13350 ENOG4105DWD nucleoside recognition domain protein FOC75_13380 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOC75_13445 ENOG4105E2A Dehydrogenase FOC75_13455 ENOG4108IJ0 Aspartate ammonia-lyase FOC75_13460 ENOG4105HDK L-asparaginase FOC75_13465 ENOG4108IMY Transcriptional regulator FOC75_13475 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC75_13480 ENOG4105CUB amino acid FOC75_13490 ENOG4105II7 pyrroline-5-carboxylate reductase FOC75_13505 ENOG4108NHD germination protein FOC75_13510 ENOG4108Q8B Spore germination protein FOC75_13530 ENOG4105CSV Glutaminase FOC75_13545 ENOG4105CGH 5'-nucleotidase FOC75_13550 ENOG4105CH6 catalase FOC75_13560 ENOG4105CHJ isochorismatase hydrolase FOC75_13585 ENOG41090MY MarR family Transcriptional regulator FOC75_13620 ENOG4108606 TspO/MBR family FOC75_13625 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOC75_13640 ENOG4108TWJ NADH dehydrogenase subunit 5 FOC75_13645 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FOC75_13660 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC75_13665 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FOC75_13700 ENOG4105D6J arsenicaL-resistance protein FOC75_13705 ENOG41085FC arsR family transcriptional regulator FOC75_13725 ENOG4105BZU Histidine kinase FOC75_13730 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC75_13745 ENOG4107P5I polyketide synthase FOC75_13750 ENOG4108IG5 Transcriptional regulator FOC75_13755 ENOG4105CHR reductase FOC75_13760 ENOG4108YXU transcriptional regulator AsnC family FOC75_13845 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOC75_13850 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC75_13860 ENOG4105IIP Membrane FOC75_13875 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC75_13880 ENOG41062D9 Histidine kinase FOC75_13905 ENOG4105K6H D-cysteine desulfhydrase FOC75_13930 ENOG4108NNI Beta-lactamase domain-containing protein FOC75_13935 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FOC75_13945 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC75_13965 ENOG4105JQZ Methyltransferase FOC75_13980 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FOC75_13985 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FOC75_14000 ENOG4105BZU Histidine kinase FOC75_14010 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC75_14015 ENOG4105DJB Major Facilitator Superfamily FOC75_14020 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) FOC75_14025 ENOG4107QR9 Iron-sulfur cluster binding protein FOC75_14035 ENOG4106P55 Transcriptional regulator FOC75_14045 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC75_14075 ENOG4105TRI Hydrolase FOC75_14110 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC75_14145 ENOG4105C44 Serine transporter FOC75_14150 ENOG4105EJQ L-serine dehydratase FOC75_14165 ENOG4108JPW Aminotransferase FOC75_14175 ENOG4105C45 hydrogenase expression formation protein (HypE) FOC75_14180 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FOC75_14190 ENOG4105DVH amino acid FOC75_14205 ENOG4108JQ1 Dehydrogenase FOC75_14225 ENOG4108AEY RNA polymerase sigma factor FOC75_14240 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC75_14245 ENOG410874W AraC family transcriptional regulator FOC75_14265 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC75_14305 ENOG4108ISG Major Facilitator FOC75_14315 ENOG4107MII Sugar-specific transcriptional regulator TrmB FOC75_14320 ENOG4105CZM Major Facilitator FOC75_14330 ENOG4105RXJ FOC75_14335 ENOG4105KPY Small multidrug resistance protein FOC75_14340 ENOG4105KBX Transcriptional regulator, TetR family FOC75_14350 ENOG4105CRW Short chain fatty acid transporter FOC75_14360 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC75_14395 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC75_14430 ENOG4105EQ0 Major Facilitator superfamily FOC75_14435 ENOG4108IND Tetr family transcriptional regulator FOC75_14450 ENOG4105EKQ RNA-directed DNA polymerase FOC75_14455 ENOG4105K59 histidine triad (HIT) protein FOC75_14460 ENOG4108Z4K mutator MutT protein FOC75_14465 ENOG4105EKQ RNA-directed DNA polymerase FOC75_14470 ENOG4108Z66 YbaK ebsC protein FOC75_14490 ENOG4105KVH Transcriptional regulator FOC75_14495 ENOG4108RCM Nitroreductase FOC75_14515 ENOG4108PSK reductase FOC75_14525 ENOG4105CJ1 ABC, transporter FOC75_14585 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FOC75_14590 ENOG4105DKQ ROK family FOC75_14595 ENOG4106UW1 Major Facilitator superfamily FOC75_14600 ENOG4108UW5 maltose o-acetyltransferase FOC75_14610 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC75_14650 ENOG4105DMQ Methyltransferase FOC75_14660 ENOG4105EV4 Multidrug resistance protein mdtH FOC75_14690 ENOG4105C37 (CBS) domain FOC75_14705 ENOG4105DDN Pentapeptide repeat-containing protein FOC75_14710 ENOG4105XDF Protein of unknown function (DUF1272) FOC75_14715 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOC75_14720 ENOG4105CMG Carbohydrate kinase FOC75_14725 ENOG4105C6Z Gluconate FOC75_14730 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC75_14745 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC75_14760 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FOC75_14780 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FOC75_14785 ENOG4105D4Y metalloprotease FOC75_14820 ENOG4105C44 Serine transporter FOC75_14860 ENOG4108TZY GntR Family Transcriptional Regulator FOC75_14865 ENOG4105D9R oxidoreductase FOC75_14870 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FOC75_14875 ENOG4105KVH Transcriptional regulator FOC75_14880 ENOG4105KVH Transcriptional regulator FOC75_14915 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC75_14925 ENOG4105CHR reductase FOC75_14935 ENOG4105KNA -acetyltransferase FOC75_14945 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FOC75_14950 ENOG4105KVH Transcriptional regulator FOC75_15005 ENOG4105KAF membrAne FOC75_15030 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FOC75_15080 ENOG4105H3G oxidoreductase FOC75_15115 ENOG4105CIS alcohol dehydrogenase FOC75_15150 ENOG4108TN2 lmbE family FOC75_15160 ENOG4107R3E Citrate transporter FOC75_15175 ENOG4108MES Periplasmic binding protein FOC75_15180 ENOG4105EHG Permease protein FOC75_15185 ENOG4105DQ5 transport system permease protein FOC75_15190 ENOG4105NX3 Membrane FOC75_15195 ENOG4107ZY0 Phenazine biosynthesis-like protein FOC75_15220 ENOG4107CUJ Protein of unknown function (DUF2690) FOC75_15230 ENOG4107V2S Transcriptional regulator FOC75_15250 ENOG4105C98 muts2 protein FOC75_15260 ENOG4105E5K Alpha-amylase FOC75_15265 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FOC75_15270 ENOG4105DPN Oligoendopeptidase f FOC75_15275 ENOG4108A04 Beta-lactamase FOC75_15305 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC75_15330 ENOG41082BM Transcriptional regulator, arsr family FOC75_15335 ENOG4105CIS alcohol dehydrogenase FOC75_15360 ENOG4105RHY Pfam:UPF0157 FOC75_15370 ENOG4105C09 Bile acid FOC75_15400 ENOG4108UT6 Transferase hexapeptide repeat containing protein FOC75_15410 ENOG4105K64 Glycosyl transferase, family 2 FOC75_15415 ENOG4105E39 Enoyl-CoA hydratase FOC75_15425 ENOG4105KT7 mgtC SapB transporter FOC75_15440 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC75_15445 ENOG41073R8 VanW family FOC75_15455 ENOG4108R1P FOC75_15475 ENOG4105VEQ Cold shock protein FOC75_15495 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOC75_15515 ENOG410904N short-chain dehydrogenase reductase FOC75_15525 ENOG4106IQC argininosuccinate lyase FOC75_15540 ENOG4108IA2 Sodium pantothenate symporter FOC75_15550 ENOG4105C26 Dehydrogenase FOC75_15555 ENOG4105CHR reductase FOC75_15565 ENOG4105EWU Squalene--hopene cyclase FOC75_15575 ENOG4105FR1 rard protein FOC75_15595 ENOG4105D1F ATP-binding protein FOC75_15605 ENOG4108ZAF Molybdopterin FOC75_15610 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC75_15615 ENOG4105D06 uba thif-type nad fad binding protein FOC75_15620 ENOG4105TMB Formate nitrite transporter FOC75_15630 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC75_15635 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FOC75_15645 ENOG4108JB9 formate dehydrogenase FOC75_15650 ENOG4105E1K spore germination protein FOC75_15715 ENOG4107QJT sodium dicarboxylate symporter FOC75_15720 ENOG4108KGH TRANSCRIPTIONal FOC75_15730 ENOG4105EMN RNA polymerase sigma factor FOC75_15750 ENOG4105CIG ABC transporter FOC75_15760 ENOG4105D9R oxidoreductase FOC75_15770 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC75_15775 ENOG4105K4P CoA-binding domain protein FOC75_15780 ENOG4105C0H protease FOC75_15785 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC75_15795 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOC75_15805 ENOG4105W8X HesB YadR YfhF-family protein FOC75_15835 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC75_15840 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC75_15850 ENOG4108JJA ABC, transporter FOC75_15855 ENOG4108I0Z Aconitate hydratase FOC75_15895 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC75_15915 ENOG4107F3J Amp-dependent synthetase and ligase FOC75_15920 ENOG4107ZYJ bioY protein FOC75_15925 ENOG4105CEY Amp-dependent synthetase and ligase FOC75_15980 ENOG4107AYK membrAne FOC75_15990 ENOG4105BZU Histidine kinase FOC75_15995 ENOG4105FBA Phospholipase Carboxylesterase FOC75_16000 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FOC75_16005 ENOG4105CK7 Sodium proline symporter FOC75_16010 ENOG4105CBC glutamate synthase FOC75_16015 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC75_16020 ENOG4108VJ1 Transcriptional regulator (CarD family FOC75_16025 ENOG4108903 Formimidoylglutamase FOC75_16090 ENOG4107QIV Cytochrome c biogenesis protein FOC75_16110 ENOG4105CJ1 ABC, transporter FOC75_16120 ENOG4107RSM transcriptional regulator FOC75_16130 ENOG41067MG lrgb family FOC75_16155 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC75_16170 ENOG4105BZ1 (ABC) transporter FOC75_16175 ENOG4105BZ1 (ABC) transporter FOC75_16195 ENOG4105D7V transposase FOC75_16210 ENOG4105D5T phosphonate abc transporter FOC75_16220 ENOG4105CGH 5'-nucleotidase FOC75_16230 ENOG4108SVB resolvase FOC75_16250 ENOG4105K7K Transcriptional regulator FOC75_16280 ENOG4105C5F glutamine synthetase FOC75_16285 ENOG4105KV4 Transcriptional regulator FOC75_16290 ENOG4105CXI aluminum resistance protein FOC75_16295 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC75_16300 ENOG4105EN6 Membrane FOC75_16305 ENOG4106F1P AAA ATPase, central domain protein FOC75_16335 ENOG41069ER domain protein FOC75_16340 ENOG4105DM4 PTS System FOC75_16345 ENOG4105DE4 1-phosphofructokinase FOC75_16350 ENOG4105E98 transcriptional regulator DeoR family FOC75_16355 ENOG4107QW4 alcohol dehydrogenase FOC75_16360 ENOG4108SJC Membrane FOC75_16370 ENOG4105C85 amino acid FOC75_16390 ENOG4105TMB Formate nitrite transporter FOC75_16395 ENOG4105K70 DNA-binding protein FOC75_16405 ENOG4105C59 p-type ATPase FOC75_16410 ENOG410681U heavy metal transport detoxification protein FOC75_16415 ENOG4105VPX protein, conserved in bacteria FOC75_16425 ENOG4105NIV Esterase FOC75_16430 ENOG4105E0A ABC, transporter FOC75_16450 ENOG4105CGK Exodeoxyribonuclease III FOC75_16460 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC75_16465 ENOG4105D03 DNA-3-methyladenine glycosylase II FOC75_16495 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC75_16500 ENOG4105BZU Histidine kinase FOC75_16515 ENOG41067MG lrgb family FOC75_16530 ENOG4107TTQ Alpha beta hydrolase fold FOC75_16535 ENOG4107YEI lmbE family FOC75_16560 ENOG4105F0V Cell wall hydrolase FOC75_16565 ENOG4107R6R udp-galactopyranose mutase FOC75_16570 ENOG4105E0M Sulfatase FOC75_16575 ENOG410890F Dynamin family FOC75_16585 ENOG4107QHE Choloylglycine hydrolase FOC75_16615 ENOG4105DQU oxidoreductase, subunit beta FOC75_16620 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FOC75_16625 ENOG4108IGT Dipeptidase FOC75_16630 ENOG4105MCT stage V sporulation protein S FOC75_16635 ENOG4105D48 metallophosphoesterase FOC75_16660 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOC75_16675 ENOG4105XZV Protein of unknown function (DUF3243) FOC75_16680 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FOC75_16700 ENOG4105UIB (ABC) transporter FOC75_16705 ENOG4108JQ9 ABC transporter FOC75_16710 ENOG4105DIH basic membrane FOC75_16715 ENOG4105FDP GntR family transcriptional regulator FOC75_16720 ENOG4107QZI cell division protein FtsK FOC75_16730 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FOC75_16740 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC75_16750 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC75_16755 ENOG4108S0H Dipicolinic acid synthetase, b subunit FOC75_16760 ENOG4105E35 Dipicolinate synthase subunit A FOC75_16770 ENOG4105C1V Peptidase, M16 FOC75_16790 ENOG4105DTN riboflavin biosynthesis protein ribF FOC75_16795 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FOC75_16805 ENOG4105W7A Protein of unknown function (DUF503) FOC75_16815 ENOG4105VHM ribosomal protein FOC75_16820 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FOC75_16825 ENOG4105CHV Transcription elongation factor NusA FOC75_16835 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC75_16845 ENOG4105DZP Membrane-associated zinc metalloprotease FOC75_16855 ENOG4105KNE Phosphatidate cytidylyltransferase FOC75_16900 ENOG4108HE4 integrase family FOC75_16910 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOC75_16915 ENOG4105C79 DNA protecting protein DprA FOC75_16920 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOC75_16935 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FOC75_16960 ENOG4105VB6 UPF0109 protein FOC75_16980 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOC75_16985 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOC75_17000 ENOG4105CHR reductase FOC75_17005 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC75_17020 ENOG4105CB5 ATP-dependent DNA helicase recG FOC75_17025 ENOG4105DP4 dak2 domain fusion protein ylov FOC75_17030 ENOG4108ZAA Alkaline-shock protein FOC75_17045 ENOG4105FJ0 thiamine FOC75_17050 ENOG4105DJV ribulose-phosphate 3-epimerase FOC75_17055 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC75_17060 ENOG4105D9P serine threonine protein kinase FOC75_17065 ENOG4108ZF3 Phosphatase FOC75_17075 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOC75_17085 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC75_17090 ENOG4105C25 Primosomal protein n' FOC75_17095 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOC75_17115 ENOG4105DSJ YicC domain protein FOC75_17130 ENOG4105DC7 peptidase M24 FOC75_17210 ENOG4105C34 Pseudouridine synthase FOC75_17235 ENOG4105DBK s4 domain protein FOC75_17240 ENOG41067XK integral membrane protein FOC75_17250 ENOG4105DFA alanine racemase domain protein FOC75_17255 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOC75_17260 ENOG4105WR5 sporulation protein, YlmC YmxH family FOC75_17270 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC75_17280 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOC75_17285 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOC75_17290 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FOC75_17295 ENOG4105D4A Cell wall formation (By similarity) FOC75_17305 ENOG4105CNI cell division protein FtsW FOC75_17320 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC75_17325 ENOG4105CJN penicillin-binding protein FOC75_17330 ENOG4105CJN penicillin-binding protein FOC75_17335 ENOG41068DC Essential cell division protein (By similarity) FOC75_17370 ENOG4105KNH Nucleic acid-binding protein FOC75_17380 ENOG41063PX domain protein FOC75_17385 ENOG4105D78 K07001 NTE family protein FOC75_17390 ENOG4105H20 Sporulation integral membrane protein YlbJ FOC75_17400 ENOG4106H78 methyltransferase FOC75_17420 ENOG4107TB6 phosphoglycerate mutase FOC75_17435 ENOG4106UY4 Inherit from COG: Scp-like extracellular FOC75_17450 ENOG4105EKQ RNA-directed DNA polymerase FOC75_17495 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FOC75_17500 ENOG4105CNI cell division protein FtsW FOC75_17515 ENOG4108IAB Phoh family FOC75_17535 ENOG4105QA2 FOC75_17540 ENOG4105CI3 gtp-binding protein typa FOC75_17550 ENOG4105ECY inositol monophosphatase FOC75_17570 ENOG4105CXN decarboxylase FOC75_17620 ENOG4105CPP Dehydrogenase, E1 component FOC75_17635 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC75_17640 ENOG4108X4Q Hydrolase FOC75_17650 ENOG4105CN5 Metallo-Beta-Lactamase FOC75_17655 ENOG4107ZYR domain protein FOC75_17690 ENOG4108XRC Protein of unknown function (DUF458) FOC75_17700 ENOG4107IN1 Protein of unknown function (DUF1797) FOC75_17715 ENOG4105EPM Diguanylate phosphodiesterase FOC75_17720 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FOC75_17735 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FOC75_17745 ENOG4105UIN FOC75_17800 ENOG4108HGU Histidine kinase FOC75_17810 ENOG4105CHM Aminotransferase FOC75_17815 ENOG4105FKQ transcriptional regulator FOC75_17820 ENOG4105EG2 ABC transporter, permease FOC75_17830 ENOG4107FKK extracellular solute-binding protein family 1 FOC75_17840 ENOG4105CG3 alpha amylase, catalytic region FOC75_17885 ENOG4105CHU acetyl-coa acetyltransferase FOC75_17925 ENOG4105DTD Dehydrogenase FOC75_17945 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOC75_17985 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC75_17990 ENOG4106TD9 Diguanylate cyclase FOC75_18010 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOC75_18025 ENOG4105CID antiterminator FOC75_18045 ENOG4105CE4 GlcNAc 6-P deacetylase FOC75_18080 ENOG4107ZE5 PPIases accelerate the folding of proteins FOC75_18085 ENOG4105PTM secreted protein FOC75_18090 ENOG4105J7I hydrolase FOC75_18100 ENOG4105G6R Stage v sporulation protein ae FOC75_18110 ENOG4105CZ3 stage V sporulation protein ad FOC75_18115 ENOG41090VF Stage v sporulation protein ac FOC75_18135 ENOG4105C8J )-transporter FOC75_18140 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC75_18150 ENOG41082AN stage II sporulation protein FOC75_18155 ENOG4105DZ1 carboxypeptidase FOC75_18160 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC75_18165 ENOG4105DVE abc transporter atp-binding protein FOC75_18195 ENOG4105D7N magnesium and cobalt transport protein CorA FOC75_18220 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC75_18230 ENOG4105I3K Ferric uptake regulator, Fur family FOC75_18235 ENOG4105MZ9 stage II sporulation protein m FOC75_18255 ENOG4105CPC Aldo Keto reductase FOC75_18265 ENOG4105RHY Pfam:UPF0157 FOC75_18285 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC75_18295 ENOG4105ETE Transcriptional regulator (LacI family FOC75_18300 ENOG4108YM7 Gcn5-related n-acetyltransferase FOC75_18320 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC75_18325 ENOG4108R6K riboflavin synthase, subunit alpha FOC75_18350 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC75_18355 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC75_18370 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC75_18380 ENOG4105DFD Na H antiporter FOC75_18385 ENOG4105CGH 5'-nucleotidase FOC75_18425 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FOC75_18440 ENOG4108IXY short-chain dehydrogenase reductase FOC75_18445 ENOG41069FQ Metallo-beta-lactamase superfamily FOC75_18450 ENOG4105II7 pyrroline-5-carboxylate reductase FOC75_18455 ENOG4105EJQ L-serine dehydratase FOC75_18480 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC75_18490 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOC75_18495 ENOG4105D9U N-acetyltransferase FOC75_18510 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FOC75_18515 ENOG4108QEG Membrane FOC75_18520 ENOG4105CDA abc transporter atp-binding protein FOC75_18525 ENOG4105E5Q amino acid AbC transporter FOC75_18530 ENOG4108HW3 (ABC) transporter FOC75_18540 ENOG4105G7B Protein of unknown function (DUF2992) FOC75_18545 ENOG4105E09 nadh pyrophosphatase FOC75_18555 ENOG4105C7S Dehydrogenase FOC75_18560 ENOG4105CPP Dehydrogenase, E1 component FOC75_18580 ENOG4107RDP Dehydrogenase FOC75_18590 ENOG4108JUB Transcriptional regulator FOC75_18600 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC75_18615 ENOG4107QQR Sporulation FOC75_18620 ENOG4105S1Z Stage IV sporulation protein B FOC75_18625 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOC75_18635 ENOG4105DX0 Hemolysin A FOC75_18645 ENOG4105CTB Polyprenyl synthetase FOC75_18670 ENOG4108ZSR alkaline shock protein FOC75_18675 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC75_18700 ENOG410644B Stage III sporulation protein af FOC75_18710 ENOG4105KQ4 Stage iii sporulation protein ad FOC75_18715 ENOG4108CQH stage III sporulation protein AC FOC75_18720 ENOG4105KR5 Stage iii sporulation protein FOC75_18725 ENOG4105CD2 stage iii sporulation protein aa FOC75_18750 ENOG4105DC7 peptidase M24 FOC75_18765 ENOG4105CBJ Metal-dependent enzyme FOC75_18775 ENOG4107YBY Hydrolase FOC75_18795 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FOC75_18800 ENOG4105WZW rhodanese family FOC75_18820 ENOG41080TC multidrug resistance protein FOC75_18855 ENOG4105CJ1 ABC, transporter FOC75_18860 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC75_18890 ENOG4105C0D helicase FOC75_19115 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC75_19120 ENOG4105C3R Methionine synthase FOC75_19130 ENOG4105C28 cystathionine FOC75_19135 ENOG4105C28 cystathionine FOC75_19155 ENOG4105C5X domain protein FOC75_19165 ENOG4105DKQ ROK family FOC75_19175 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOC75_19190 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOC75_19200 ENOG4105E2Z phosphate ABC transporter (Permease FOC75_19205 ENOG4105C8U phosphate abc transporter FOC75_19210 ENOG4105PWN phosphate abc transporter FOC75_19215 ENOG4107RF6 penicillin-binding protein FOC75_19225 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC75_19250 ENOG4105N80 Ferric uptake regulator, Fur family FOC75_19260 ENOG4105FDK ABC transporter FOC75_19265 ENOG4108JYZ YitT family FOC75_19270 ENOG41069ZM Protein of unknown function (DUF2624) FOC75_19295 ENOG4105EGD dinuclear metal center protein, YbgI family FOC75_19310 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC75_19315 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOC75_19345 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOC75_19350 ENOG4105KG3 cytidine deaminase FOC75_19355 ENOG4107YR5 Diacylglycerol kinase FOC75_19365 ENOG4105CTJ Metal Dependent Phosphohydrolase FOC75_19370 ENOG4105C9A Phoh family FOC75_19380 ENOG41068P3 sporulation protein YqfC FOC75_19385 ENOG4105KTH gatB Yqey FOC75_19395 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC75_19400 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOC75_19430 ENOG4105CSA Coproporphyrinogen iii oxidase FOC75_19435 ENOG4105KVH Transcriptional regulator FOC75_19460 ENOG4105TQK DNA polymerase iii, delta' subunit FOC75_19470 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC75_19475 ENOG4108UK2 deaminase FOC75_19480 ENOG4105KQC Competence protein FOC75_19490 ENOG4105DXX methyltransferase FOC75_19500 ENOG4108WF2 Metal Dependent Phosphohydrolase FOC75_19510 ENOG410812S Rna-binding protein FOC75_19520 ENOG4105CQW ribosome biogenesis GTPase YqeH FOC75_19525 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FOC75_19540 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC75_19560 ENOG4108TVJ Nitroreductase FOC75_19575 ENOG4105G6Z alkaline phosphatase FOC75_19585 ENOG4108MUZ hydrolase FOC75_19620 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC75_19625 ENOG4105MIR Phenylalanine 4-monooxygenase FOC75_19635 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC75_19675 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC75_19680 ENOG4108V5C ABC transporter FOC75_19690 ENOG4105C0A alcohol dehydrogenase FOC75_19695 ENOG4105C28 cystathionine FOC75_19725 ENOG4107XRG penicillin-binding protein FOC75_19740 ENOG4105CFP Peptidase U32 FOC75_19745 ENOG4105XYU peptidase (U32 family) FOC75_19755 ENOG4105HHA aminodeoxychorismate lyase FOC75_19785 ENOG4105C02 permease FOC75_19800 ENOG41060CR FOC75_19805 ENOG4105C7H Helicase, RecD TraA family FOC75_19820 ENOG4105C3J Cysteine desulfurase FOC75_19830 ENOG4105D1H recombination factor protein RarA FOC75_19835 ENOG4108VCI transcription factor, rsfa family FOC75_19840 ENOG4105CUZ uba thif-type nad fad binding protein FOC75_19870 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC75_19880 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC75_19885 ENOG41076HS cation diffusion facilitator family transporter FOC75_19890 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC75_19900 ENOG4105CKP Polysaccharide Biosynthesis Protein FOC75_19905 ENOG4108QG2 Membrane FOC75_19915 ENOG4105VIE preprotein translocase, subunit YajC FOC75_19930 ENOG41061AI Protein of unknown function (DUF2905) FOC75_19945 ENOG4108HUF Transporter FOC75_19975 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOC75_19980 ENOG4108IYU L-aspartate oxidase FOC75_19995 ENOG4108RPX mosc domain containing protein FOC75_20000 ENOG4105CQC Prephenate dehydratase FOC75_20020 ENOG4105EWM Histidine kinase FOC75_20045 ENOG4105X36 (ribosomal) protein FOC75_20055 ENOG4105C03 ribonuclease FOC75_20070 ENOG4107QMS site-determining protein FOC75_20090 ENOG4105DFF Rod shape-determining protein mreb FOC75_20110 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC75_20115 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FOC75_20125 ENOG41068KH stage VI sporulation protein D FOC75_20135 ENOG4105D52 delta-aminolevulinic acid dehydratase FOC75_20160 ENOG4105K56 Transcriptional regulator FOC75_20180 ENOG4108IUQ atp-dependent protease FOC75_20210 ENOG4108QCI YvbH-like oligomerisation region FOC75_20230 ENOG4105M59 Phosphodiesterase, mj0936 family FOC75_20245 ENOG4108XJQ germination protein FOC75_20255 ENOG4108PCX Major Facilitator FOC75_20265 ENOG4105KBX Transcriptional regulator, TetR family FOC75_20280 ENOG4105PFC Transcriptional regulator FOC75_20315 ENOG41089UC methyltransferase, type 11 FOC75_20320 ENOG410904A RNA polymerase FOC75_20345 ENOG41082YX Transcriptional regulator, arsr family FOC75_20360 ENOG4105D6J arsenicaL-resistance protein FOC75_20385 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC75_20410 ENOG4105PFC Transcriptional regulator FOC75_20425 ENOG4105DZC cytosine deaminase FOC75_20430 ENOG4105DZC cytosine deaminase FOC75_20435 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC75_20440 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC75_20455 ENOG4108JQ7 (ABC) transporter FOC75_20460 ENOG4108HRK Histidine kinase FOC75_20465 ENOG4105DY9 regulatoR FOC75_20475 ENOG41067S9 phage shock protein C, PspC FOC75_20480 ENOG4108JCI Transcriptional regulator FOC75_20490 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOC75_20495 ENOG4108Z40 Transcriptional regulator FOC75_20500 ENOG4105RHA ABC transporter, permease FOC75_20505 ENOG4108IUX (ABC) transporter FOC75_20510 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FOC75_20515 ENOG4105ER2 Ompa motb domain protein FOC75_20520 ENOG4105E14 MotA TolQ exbB proton channel FOC75_20525 ENOG4108VXD carboxy-peptidase FOC75_20535 ENOG4105E33 succinate dehydrogenase FOC75_20545 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FOC75_20560 ENOG4105K63 Thioredoxin FOC75_20565 ENOG4105C10 Electron transfer flavoprotein FOC75_20570 ENOG4105BZJ Electron transfer flavoprotein FOC75_20575 ENOG41060WC Enoyl-CoA hydratase FOC75_20580 ENOG4107Z3H Transcriptional regulator, TetR family FOC75_20585 ENOG4105CEY Amp-dependent synthetase and ligase FOC75_20595 ENOG4105J76 Periplasmic binding protein FOC75_20600 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC75_20640 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC75_20655 ENOG4105DR4 Methyltransferase FOC75_20670 ENOG4105KFN sortase, SrtB family FOC75_20675 ENOG4105E0A ABC, transporter FOC75_20690 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FOC75_20700 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FOC75_20710 ENOG4105FE9 pseudouridine synthase FOC75_20720 ENOG4105DCG PHP domain protein FOC75_20770 ENOG4108RWN rrna methyltransferase FOC75_20805 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC75_20810 ENOG4105CW7 secretion protein, HlyD family FOC75_20815 ENOG4108JGH Tetr family transcriptional regulator FOC75_20820 ENOG4105CN9 Peptidase m42 family protein FOC75_20845 ENOG4105C22 threonyL-tRNA synthetase FOC75_20850 ENOG4108TDW sporulation protein YtxC FOC75_20875 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOC75_20880 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOC75_20895 ENOG4105C2M dna polymerase I FOC75_20900 ENOG4105BZU Histidine kinase FOC75_20905 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC75_20925 ENOG4108HMX isocitrate dehydrogenase (NADP) FOC75_20930 ENOG4105BZN citrate synthase FOC75_20940 ENOG4108REF Sporulation integral membrane protein ytvi FOC75_20945 ENOG4105FS0 cytoplasmic membrane protein FOC75_20970 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC75_20975 ENOG4105C6K Malic enzyme FOC75_20980 ENOG4105C0B DNA polymerase III (alpha subunit) FOC75_20985 ENOG4105VV2 FOC75_20995 ENOG4105SFS phosphoesterase RecJ domain protein FOC75_21030 ENOG4105DC7 peptidase M24 FOC75_21075 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC75_21085 ENOG4105VZ8 Transcriptional regulator FOC75_21105 ENOG4107YZX Universal stress protein FOC75_21145 ENOG4108JYZ YitT family FOC75_21175 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FOC75_21180 ENOG4105KBJ sporulation protein ytfj FOC75_21195 ENOG4105EFZ amidohydrolase FOC75_21205 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC75_21230 ENOG4106KR7 LysR family Transcriptional regulator FOC75_21240 ENOG4105U5Y Transcriptional regulator FOC75_21250 ENOG4105C28 cystathionine FOC75_21280 ENOG4105EMN RNA polymerase sigma factor FOC75_21295 ENOG4105F1V Acetoin utilization protein FOC75_21300 ENOG4105W87 Cbs domain FOC75_21305 ENOG4105DGU Histone deacetylase FOC75_21310 ENOG4106HB6 Alpha beta hydrolase FOC75_21320 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC75_21330 ENOG4107SNB ankyrin repeat protein YahD FOC75_21335 ENOG4105EP9 oxidoreductase FOC75_21365 ENOG4105ETE Transcriptional regulator (LacI family FOC75_21385 ENOG4105C88 aminopeptidase FOC75_21435 ENOG4108VDD TRNA binding domain protein FOC75_21465 ENOG4105C8F Beta-lactamase domain protein FOC75_21480 ENOG4108V15 phosphotransferase enzyme family FOC75_21485 ENOG4108IUM Glycogen debranching enzyme FOC75_21495 ENOG4107QSE Dipeptidase FOC75_21500 ENOG4105YW5 deoR family transcriptional regulator FOC75_21515 ENOG4105CBX hi0933 family FOC75_21550 ENOG4108VJ1 Transcriptional regulator (CarD family FOC75_21555 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC75_21575 ENOG4108ZAF Molybdopterin FOC75_21580 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FOC75_21585 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC75_21595 ENOG4105D06 uba thif-type nad fad binding protein FOC75_21600 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC75_21620 ENOG41085GJ domain protein FOC75_21630 ENOG4105DWV Homoserine O-trans-acetylase FOC75_21640 ENOG4108B31 Spore germination protein FOC75_21670 ENOG410605W Major Facilitator FOC75_21675 ENOG4107S91 Sodium hydrogen exchanger FOC75_21680 ENOG4105NCW Trka-c domain protein FOC75_21695 ENOG4105C19 ABC transporter FOC75_21715 ENOG4105N5T Radical SAM Protein FOC75_21725 ENOG4105CIG ABC transporter FOC75_21755 ENOG4105E8V Alpha Beta Hydrolase Fold protein FOC75_21760 ENOG4108Z0R Transferase FOC75_21765 ENOG4105YVM Phosphoesterase, PA-phosphatase related FOC75_21770 ENOG4105BZF Glycosyl transferase (Group 1 FOC75_21780 ENOG4108RIR Molybdenum cofactor biosynthesis protein FOC75_21835 ENOG4105EGD dinuclear metal center protein, YbgI family FOC75_21840 ENOG4105BZU Histidine kinase FOC75_21845 ENOG4105BZU Histidine kinase FOC75_21850 ENOG4107S9D Alpha beta hydrolase FOC75_21855 ENOG4107T7U Sulfatase FOC75_21870 ENOG4105D2X ABC transporter substrate-binding protein FOC75_21880 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOC75_21895 ENOG4107XGZ Hydrolase FOC75_21940 ENOG4108V2W Carbonate dehydratase FOC75_21945 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC75_21950 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC75_21995 ENOG41087YS Phage shock protein A FOC75_22035 ENOG4105BZU Histidine kinase FOC75_22040 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC75_22065 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC75_22070 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FOC75_22095 ENOG4107ZTW SNARE associated Golgi FOC75_22110 ENOG4105C19 ABC transporter FOC75_22115 ENOG41086D8 Transcriptional regulator FOC75_22180 ENOG41069H0 dihydroorotase EC 3.5.2.3 FOC75_22210 ENOG4105DTQ mandelate racemase muconate lactonizing FOC75_22220 ENOG4108IPT Naphthoate synthase FOC75_22225 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FOC75_22235 ENOG4105E4F Isochorismate synthase FOC75_22240 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC75_22250 ENOG4105VEQ Cold shock protein FOC75_22310 ENOG4105JVQ RNA Polymerase FOC75_22405 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOC75_22440 ENOG4105KT7 mgtC SapB transporter FOC75_22445 ENOG4107PBV potassium channel FOC75_22460 ENOG4105WG9 Conserved Protein FOC75_22470 ENOG4105CHM Aminotransferase FOC75_22475 ENOG4108ZB6 transcriptional regulator AsnC family FOC75_22480 ENOG4105C5I Dehydrogenase FOC75_22485 ENOG4108MUZ hydrolase FOC75_22495 ENOG4105C87 Aminotransferase class I and II FOC75_22510 ENOG4105Y38 Kinase-associated protein B FOC75_22520 ENOG4107R3E Citrate transporter FOC75_22540 ENOG4105KA0 thioesterase Superfamily protein FOC75_22555 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC75_22575 ENOG41069ER domain protein FOC75_22595 ENOG4105CEP NADH dehydrogenase FOC75_22625 ENOG4105EWC Purine nucleoside phosphorylase FOC75_22635 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOC75_22660 ENOG4108JJA ABC, transporter FOC75_22665 ENOG4105C4B ABC transporter, permease FOC75_22670 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOC75_22695 ENOG41083MR nifu domain-containing protein FOC75_22710 ENOG4108W5N phosphatidylglycerophosphatase a FOC75_22720 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC75_22730 ENOG4105D4U had-superfamily hydrolase, subfamily iia FOC75_22745 ENOG4105CBT Fructose-1,6-bisphosphatase FOC75_22760 ENOG4105MMD transcriptional regulator FOC75_22765 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FOC75_22770 ENOG4107TXC Transcriptional regulator FOC75_22775 ENOG41090T1 Membrane FOC75_22800 ENOG4105FAA peptidase M23 FOC75_22810 ENOG4105KZD Domain of unknown function (DUF1805) FOC75_22815 ENOG4107R8B 5'-nucleotidase FOC75_22820 ENOG4105DIW FeS assembly protein SUFB FOC75_22825 ENOG4108UNV SUF system FeS assembly protein, NifU family FOC75_22830 ENOG4105C9B Cysteine desulfurase FOC75_22835 ENOG4105JRK feS assembly protein SufD FOC75_22840 ENOG4105C3K feS assembly ATPase SufC FOC75_22845 ENOG4105D01 (LipO)protein FOC75_22850 ENOG4105D01 (LipO)protein FOC75_22855 ENOG4108UMI ABC transporter, permease FOC75_22885 ENOG41080E8 Transcriptional regulator, Spx MgsR family FOC75_22955 ENOG4108IMY Transcriptional regulator FOC75_22965 ENOG4108W8B Beta-lactamase domain protein FOC75_22970 ENOG4105C1G acyl-Coa dehydrogenase FOC75_22980 ENOG4105CHU acetyl-coa acetyltransferase FOC75_22995 ENOG4105DZ1 carboxypeptidase FOC75_23015 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC75_23035 ENOG4108SUT Major Facilitator Superfamily FOC75_23040 ENOG4107R7I amino acid FOC75_23050 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC75_23060 ENOG4107AYK membrAne FOC75_23095 ENOG4107ZTW SNARE associated Golgi FOC75_23105 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC75_23110 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC75_23115 ENOG4105BZU Histidine kinase FOC75_23135 ENOG4105C8Q Methyl-accepting chemotaxis FOC75_23140 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC75_23145 ENOG4105VG1 fes assembly suf system protein FOC75_23150 ENOG4105D4Y metalloprotease FOC75_23170 ENOG4107S91 Sodium hydrogen exchanger FOC75_23175 ENOG4105NCW Trka-c domain protein FOC75_23185 ENOG4108RMU ferritin dps family protein FOC75_23200 ENOG4108URH decarboxylase FOC75_23220 ENOG4105D9N nucleoside FOC75_23225 ENOG4105D9N nucleoside FOC75_23235 ENOG4108RYK Nad-dependent epimerase dehydratase FOC75_23255 ENOG4105CV8 reductase FOC75_23260 ENOG4105F27 Major Facilitator FOC75_23265 ENOG4105KVH Transcriptional regulator FOC75_23280 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC75_23285 ENOG4105D4A Cell wall formation (By similarity) FOC75_23310 ENOG4105C8Q Methyl-accepting chemotaxis FOC75_23340 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC75_23360 ENOG4108IPW abc transporter atp-binding protein FOC75_23365 ENOG4105CM4 permease protein FOC75_23380 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC75_23400 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOC75_23410 ENOG4105XZU Preprotein translocase, subunit SecG FOC75_23415 ENOG41067MG lrgb family FOC75_23465 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC75_23485 ENOG41090VF Stage v sporulation protein ac FOC75_23490 ENOG4105CZ3 stage V sporulation protein ad FOC75_23505 ENOG4105H67 Protein of unknown function (DUF421) FOC75_23515 ENOG4105KRI phosphocarrier protein (HPr FOC75_23525 ENOG4105CHW UPF0052 protein FOC75_23535 ENOG4108Z4K mutator MutT protein FOC75_23545 ENOG4105C3M thioredoxin reductase FOC75_23555 ENOG4108S4C acetyltransferase FOC75_23575 ENOG41086DT Membrane protein of unknown function FOC75_23585 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC75_23590 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOC75_23605 ENOG4107TXC Transcriptional regulator FOC75_23635 ENOG4105HMI Membrane FOC75_23640 ENOG4105DUM transcriptional regulator, lysR family FOC75_23650 ENOG4108WS4 fmn reductase FOC75_23665 ENOG4105BZ1 (ABC) transporter FOC75_23675 ENOG4105CN1 protease FOC75_23680 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOC75_23685 ENOG4105CAK Cell division ATP-binding protein ftsE FOC75_23705 ENOG4105MS2 ribosomal subunit Interface protein FOC75_23710 ENOG4105VEQ Cold shock protein FOC75_23715 ENOG41081UC Inherit from COG: Competence protein FOC75_23730 ENOG4105KVH Transcriptional regulator FOC75_23740 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOC75_23745 ENOG4108KGH TRANSCRIPTIONal FOC75_23750 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC75_23755 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC75_23760 ENOG4105ESV Glycosyl transferase, family 4 FOC75_23770 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC75_23790 ENOG4105F8D glycoside hydrolase family 4 FOC75_23795 ENOG4105VCP PTS System FOC75_23800 ENOG4105CK1 PTS System FOC75_23810 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FOC75_23820 ENOG4105VCP PTS System FOC75_23830 ENOG4105VZJ PTS System FOC75_23845 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FOC75_23850 ENOG4105ECB domain protein FOC75_23855 ENOG4107RSM transcriptional regulator FOC75_23910 ENOG4105DAA L-lactate FOC75_23920 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FOC75_23930 ENOG4105E0M Sulfatase FOC75_23955 ENOG4107R8N Glycosyl transferase, family 2 FOC75_23960 ENOG4105C94 Transporter FOC75_23965 ENOG41069ER domain protein FOC75_23990 ENOG4105KBK Zinc finger, swim domain protein FOC75_23995 ENOG4105C0D helicase FOC75_24025 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC75_24040 ENOG4107RBB ABC transporter, permease FOC75_24045 ENOG4105C19 ABC transporter FOC75_24055 ENOG4105CXY transporter FOC75_24070 ENOG4105BZU Histidine kinase FOC75_24075 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC75_24080 ENOG4105CMR udp-glucose 4-epimerase FOC75_24095 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC75_24100 ENOG4107VDP teichoic acid biosynthesis FOC75_24105 ENOG4105EY8 ABC transporter FOC75_24115 ENOG4107SJB teichoic acid biosynthesis FOC75_24120 ENOG4107SJB teichoic acid biosynthesis FOC75_24125 ENOG4107RZX Teichoic acid biosynthesis protein FOC75_24130 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase FOC75_24140 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FOC75_24145 ENOG4107BJW polysaccharide deacetylase FOC75_24155 ENOG4105FRN stage II sporulation protein FOC75_24170 ENOG4105DY9 regulatoR FOC75_24190 ENOG4106778 Protein of unknown function (DUF1146) FOC75_24195 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC75_24200 ENOG4105C8S subunit m FOC75_24205 ENOG4105D65 subunit l FOC75_24230 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC75_24235 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC75_24250 ENOG4105BZU Histidine kinase FOC75_24300 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FOC75_24305 ENOG41062M3 atp synthase FOC75_24335 ENOG4108YZG isomerase FOC75_24350 ENOG4108VGI doxx family FOC75_24355 ENOG4107XC4 flavin reductase domain protein, FMN-binding FOC75_24370 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC75_24380 ENOG4108ZXQ stage ii sporulation protein r FOC75_24385 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC75_24405 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOC75_24410 ENOG4105CBT Fructose-1,6-bisphosphatase FOC75_24450 ENOG4105C1G acyl-Coa dehydrogenase FOC75_24455 ENOG4105C1G acyl-Coa dehydrogenase FOC75_24460 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC75_24470 ENOG4105DF6 Fe-S oxidoreductase FOC75_24485 ENOG4105BZU Histidine kinase FOC75_24515 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FOC75_24525 ENOG4105IIU Aminopeptidase FOC75_24545 ENOG4105EMN RNA polymerase sigma factor FOC75_24555 ENOG410684U Domain of unknown function (DUF1934) FOC75_24575 ENOG4105CYW agmatinase FOC75_24585 ENOG4105DXB Major Facilitator superfamily FOC75_24590 ENOG4107SWG transcriptional regulator MERR family FOC75_24595 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC75_24600 ENOG4105BZ4 penicillin-binding protein FOC75_24605 ENOG4108XFG YwhD family FOC75_24610 ENOG4108Z4T Peptidase M50 FOC75_24615 ENOG41069HH 4-oxalocrotonate tautomerase FOC75_24620 ENOG4105DCI Phosphohydrolase FOC75_24625 ENOG4108MES Periplasmic binding protein FOC75_24630 ENOG4105E0A ABC, transporter FOC75_24635 ENOG4105EHG Permease protein FOC75_24640 ENOG4105DQ5 transport system permease protein FOC75_24650 ENOG4108VCI transcription factor, rsfa family FOC75_24670 ENOG4108IJ2 phosphate acetyltransferase FOC75_24685 ENOG4108VKI Cell wall hydrolase FOC75_24705 ENOG4107SVH Potassium channel protein FOC75_24715 ENOG410667J hydrolase FOC75_24720 ENOG4105VCH membrane FOC75_24730 ENOG4108TU7 Inherit from COG: (ABC) transporter FOC75_24735 ENOG4105CJ1 ABC, transporter FOC75_24740 ENOG41090WU lipolytic protein G-D-S-L family FOC75_24755 ENOG4105D6E homoserine dehydrogenase FOC75_24780 ENOG4108Y4K DNA-binding transcriptional activator FOC75_24790 ENOG4105WH1 Two component transcriptional regulator luxr family FOC75_24795 ENOG4105BZU Histidine kinase FOC75_24800 ENOG4105DWF phosphomethylpyrimidine kinase FOC75_24805 ENOG4105BZU Histidine kinase FOC75_24810 ENOG4105VCD cytoplasmic protein FOC75_24815 ENOG4105D22 carbon starvation protein FOC75_24820 ENOG4105DY9 regulatoR FOC75_24825 ENOG41079KZ Major Facilitator Superfamily FOC75_24845 ENOG4105EN6 Membrane FOC75_24850 ENOG4106YBV Methyl-accepting chemotaxis FOC75_24860 ENOG4108S4H thioesterase Superfamily protein FOC75_24870 ENOG4105JEU Glycosyl transferase, family 2 FOC75_24875 ENOG4105C5H ABC transporter FOC75_24895 ENOG4105CKK Glycosyl transferase, family 2 FOC75_24900 ENOG41067SE Tetr family transcriptional regulator FOC75_24910 ENOG4105E0X reductase FOC75_24915 ENOG4106F5Q Membrane FOC75_24930 ENOG4105DY9 regulatoR FOC75_24935 ENOG4108HRK Histidine kinase FOC75_24940 ENOG4107RGD Major Facilitator superfamily FOC75_24955 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC75_24965 ENOG4105IW1 AmiS UreI transporter FOC75_24975 ENOG4105CMR udp-glucose 4-epimerase FOC75_24980 ENOG4108UT2 hemolysin iii FOC75_24990 ENOG4105C1J atp-dependent rna helicase FOC75_25005 ENOG4105DPN Oligoendopeptidase f FOC75_25025 ENOG4105C0H protease FOC75_25030 ENOG4105Q2H domain protein FOC75_25045 ENOG4105BZU Histidine kinase FOC75_25050 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC75_25080 ENOG4105CDU Replicative dna helicase FOC75_25090 ENOG4105BZR domain protein FOC75_25095 ENOG4108XMW Membrane FOC75_25105 ENOG4108UUM single-stranded DNA-binding protein FOC75_25115 ENOG4105C3G gtp-binding protein FOC75_25120 ENOG4105VDK protein, conserved in bacteria FOC75_25125 ENOG4105D8X mechanosensitive ion channel FOC75_25130 ENOG4108ZDA Sporulation protein YyaC FOC75_25135 ENOG4105FA0 parb-like partition protein FOC75_25140 ENOG4107QJE Chromosome Partitioning Protein FOC75_25170 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC75_25190 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC75_25195 ENOG410848D S4 domain protein YaaA FOC75_25210 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC75_25245 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOC75_25280 ENOG4105ZMH deoxynucleoside kinase FOC75_25290 ENOG4105GTG Isochorismatase FOC75_25295 ENOG4108Z6B deaminase FOC75_25305 ENOG4105C6E dna polymerase iii FOC75_25325 ENOG41067KS pro-sigma K processing FOC75_25360 ENOG4105CXN decarboxylase FOC75_25370 ENOG4105FA2 dna polymerase iii FOC75_25375 ENOG4105MA4 psp1 domain protein FOC75_25385 ENOG41060K3 Methyltransferase FOC75_25395 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOC75_25400 ENOG4105KRN Transcriptional regulator, abrb family FOC75_25410 ENOG4105F8V Hydrolase, tatD family FOC75_25415 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FOC75_25425 ENOG4105XFA sporulation peptidase YabG FOC75_25430 ENOG4105W42 Veg protein FOC75_25445 ENOG4105DFT pur operon repressor FOC75_25450 ENOG4105KME endoribonuclease L-psp FOC75_25480 ENOG4108JA2 transcriptioN-repair coupling factor FOC75_25485 ENOG4108M14 stage v sporulation protein t FOC75_25495 ENOG4108IY2 MazG family FOC75_25500 ENOG41082I2 s4 domain protein FOC75_25505 ENOG4105VYY sporulation protein yabp FOC75_25520 ENOG41060GV RNA binding s1 domain protein FOC75_25545 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC75_25550 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC75_25565 ENOG4105C6T cysteine synthase FOC75_25570 ENOG4105CRQ synthase (Component I) FOC75_25575 ENOG4105DDQ anthranilate synthase FOC75_25580 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FOC75_25585 ENOG4105EEI dihydropteroate synthase FOC75_25590 ENOG4105KRF dihydroneopterin aldolase FOC75_25595 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOC75_25605 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC75_25695 ENOG4108Z0C Uvrb UvrC protein FOC75_25710 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOC75_25720 ENOG4105CTP PilT protein domain protein FOC75_25740 ENOG4105D7W serine acetyltransferase FOC75_25755 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOC75_25760 ENOG4105M0M Tetracycline resistance protein FOC75_25765 ENOG4105QIV RNA polymerase FOC75_25780 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOC75_25805 ENOG4107Y49 methyltransferase FOC75_25820 ENOG4105XPM ribosomal protein FOC75_25950 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC75_25960 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC75_26005 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC75_26035 ENOG4105D1F ATP-binding protein FOC75_26050 ENOG4108NMV polysaccharide deacetylase FOC75_26130 ENOG4105C8B TIGR00159 family FOC75_26135 ENOG4107U5W ybbr family FOC75_26160 ENOG4108VQT Alpha beta hydrolase fold protein FOC75_26170 ENOG4105CMG Carbohydrate kinase FOC75_26180 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FOC75_26185 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FOC75_26215 ENOG4108PSK reductase FOC75_26220 ENOG4108UMI ABC transporter, permease FOC75_26225 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC75_26230 ENOG4105D01 (LipO)protein FOC75_26245 ENOG4105IQ5 FAD linked oxidase domain protein FOC75_26260 ENOG4105C2C drug resistance transporter, Bcr CflA FOC75_26275 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC75_26280 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC75_26285 ENOG4105C3U ABC transporter FOC75_26290 ENOG4108JQ7 (ABC) transporter FOC75_26315 ENOG4105U5Y Transcriptional regulator FOC75_26325 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC75_26330 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC75_26340 ENOG4105II7 pyrroline-5-carboxylate reductase FOC75_26345 ENOG4107XDY Nicotinamide Mononucleotide Transporter FOC75_26355 ENOG4105E0C molybdate abc transporter FOC75_26360 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC75_26365 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FOC75_26395 ENOG4105F6E Acyl-transferase FOC75_26415 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC75_26425 ENOG4108RE7 deoxyribonuclease FOC75_26430 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FOC75_26455 ENOG4105C5H ABC transporter FOC75_26460 ENOG4105BZU Histidine kinase FOC75_26465 ENOG4105WH1 Two component transcriptional regulator luxr family FOC75_26470 ENOG4105CJ1 ABC, transporter FOC75_26475 ENOG41090VJ ABC-2 type transporter FOC75_26480 ENOG4108KYE ABC-2 type transporter FOC75_26495 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC75_26505 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC75_26510 ENOG4105C3U ABC transporter FOC75_26515 ENOG4108JQ7 (ABC) transporter FOC75_26520 ENOG410667J hydrolase FOC75_26550 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FOC75_26555 ENOG4105ERH Fumarylacetoacetate hydrolase FOC75_26565 ENOG4108SC4 )-transporter FOC75_26570 ENOG4105CPF Cell wall formation (By similarity) FOC75_26575 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOC75_26590 ENOG4107ZXI Rhomboid family FOC75_26600 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FOC75_26605 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC75_26615 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FOC75_26715 ENOG4105K8N protein family UPF0079, ATPase FOC75_26720 ENOG41072GX Peptidase M22 Glycoprotease FOC75_26725 ENOG410801F ribosomal-protein-alanine acetyltransferase FOC75_26735 ENOG4105C5H ABC transporter FOC75_26750 ENOG4108TYN CAAX amino terminal protease family protein FOC75_26770 ENOG4105C7N Xanthine uracil vitamin C permease FOC75_26780 ENOG4105BZU Histidine kinase FOC75_26805 ENOG4107ZXU DSBA oxidoreductase FOC75_26850 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC75_26870 ENOG4105SX7 Transporter FOC75_26895 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOC75_26900 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOC75_26905 ENOG4105C83 adenylosuccinate lyase FOC75_26915 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FOC75_26940 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOC75_26950 ENOG4105C12 Phosphoribosylglycinamide synthetase FOC75_26975 ENOG4105C4R Atp-dependent dna helicase FOC75_27005 ENOG4108W2Y isochorismatase FOC75_27010 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC75_27015 ENOG4108UMI ABC transporter, permease FOC75_27020 ENOG4105D01 (LipO)protein FOC75_27040 ENOG410834F Transcriptional regulator FOC75_27045 ENOG4107I77 yiaA/B two helix domain FOC75_27065 ENOG4105CBD Diacylglycerol kinase FOC75_27070 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC75_27075 ENOG4108JPW Aminotransferase FOC75_27085 ENOG4105C26 Dehydrogenase FOC75_27090 ENOG4105KPY Small multidrug resistance protein FOC75_27110 ENOG4105D9N nucleoside FOC75_27115 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC75_27130 ENOG4108W15 Protein of unknown function (DUF1456) FOC75_27145 ENOG4105DTQ mandelate racemase muconate lactonizing FOC75_27155 ENOG4105DFD Na H antiporter FOC75_27175 ENOG4105D3R alkyl hydroperoxide reductase FOC75_27195 ENOG4105EHG Permease protein FOC75_27200 ENOG4105DQ5 transport system permease protein FOC75_27205 ENOG4108V5C ABC transporter FOC75_27225 ENOG4106UIA FOC75_27230 ENOG4106UIA FOC75_27255 ENOG4105BZU Histidine kinase FOC75_27275 ENOG410756H nucleotidyltransferase FOC75_27280 ENOG4105D2S major facilitator superfamily FOC75_27295 ENOG4105E5Q amino acid AbC transporter FOC75_27300 ENOG4105EAB amino acid AbC transporter FOC75_27310 ENOG4105C8Q Methyl-accepting chemotaxis FOC75_27335 ENOG4105C5B carbamate kinase FOC75_27355 ENOG4105CI1 PTS System FOC75_27385 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FOC75_27400 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC75_27415 ENOG4105C5H ABC transporter FOC75_27445 ENOG41062JF Transcriptional regulator FOC75_27465 ENOG4105DEU major facilitator superfamily FOC75_27495 ENOG4108N0M stress protein FOC75_27500 ENOG4106FN3 tellurium resistance protein FOC75_27505 ENOG4106FN3 tellurium resistance protein FOC75_27510 ENOG4107TS3 membrane protein, TerC FOC75_27515 ENOG4108TTB tellurium resistance protein FOC75_27535 ENOG4105KJF protein tyrosine phosphatase FOC75_27545 ENOG4107U9T Pfam:Ribonuclease_BN FOC75_27550 ENOG4105C59 p-type ATPase FOC75_27555 ENOG4108IPJ Membrane FOC75_27580 ENOG4107ZTW SNARE associated Golgi FOC75_27595 ENOG410606W general stress protein FOC75_27600 ENOG4105UPD Calcium Proton FOC75_27635 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC75_27685 ENOG4108A04 Beta-lactamase FOC75_27700 ENOG4105CKK Glycosyl transferase, family 2 FOC75_27705 ENOG4107QQG Dehydrogenase FOC75_27710 ENOG4105C3I Nad-dependent epimerase dehydratase FOC75_27730 ENOG4105F1A Pyruvate formate-lyase FOC75_27825 ENOG4105K63 Thioredoxin FOC75_27835 ENOG4105EAB amino acid AbC transporter FOC75_27840 ENOG4105E5Q amino acid AbC transporter FOC75_27845 ENOG4105CDA abc transporter atp-binding protein FOC75_27855 ENOG4107R16 Multicopper oxidase FOC75_27860 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC75_27865 ENOG4105BZU Histidine kinase FOC75_27875 ENOG4108ZRV stage ii sporulation protein p FOC75_27930 ENOG4105D9M gamma-glutamylcysteine synthetase FOC75_27940 ENOG4105C4W S-formylglutathione hydrolase FOC75_27950 ENOG4105KVH Transcriptional regulator FOC75_27965 ENOG4105E1K spore germination protein FOC75_27970 ENOG4108B31 Spore germination protein FOC75_27990 ENOG4108QY0 Membrane FOC75_28005 ENOG4105CZ3 stage V sporulation protein ad FOC75_28010 ENOG41090VF Stage v sporulation protein ac FOC75_28025 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC75_28040 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FOC75_28080 ENOG41086D8 Transcriptional regulator FOC75_28100 ENOG4108W2Y isochorismatase FOC75_28110 ENOG4108NHD germination protein FOC75_28130 ENOG4107XGZ Hydrolase FOC75_28140 ENOG4105YWU small acid-soluble spore protein FOC75_28160 ENOG4107A6P FOC75_28170 ENOG4105EKQ RNA-directed DNA polymerase FOC75_28190 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC75_28195 ENOG41089BK Glutamine amido-transferase FOC75_28205 ENOG4106J6E FOC75_28240 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOC75_28325 ENOG4105EKQ RNA-directed DNA polymerase FOC75_28395 ENOG4105TQK DNA polymerase iii, delta' subunit FOC75_28405 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC75_28420 ENOG4105EKQ RNA-directed DNA polymerase FOC75_28475 ENOG4105EKQ RNA-directed DNA polymerase FOC75_28545 ENOG4105EKQ RNA-directed DNA polymerase FOC75_28565 ENOG4105K4H Nlp p60 protein FOC75_28600 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC75_28700 ENOG4105D7V transposase FOC75_28845 ENOG41067QW Transcriptional regulator FOC75_28875 ENOG4105C6E dna polymerase iii FOC75_28885 ENOG4105ENA helicase FOC75_28890 ENOG4105FA2 dna polymerase iii FOC75_28910 ENOG4108TF4 von Willebrand factor, type A FOC75_28915 ENOG4105KRN Transcriptional regulator, abrb family FOC75_28985 ENOG4105D6J arsenicaL-resistance protein FOC75_28990 ENOG41082YX Transcriptional regulator, arsr family FOC75_29005 ENOG4105CKI cobalamin synthesis protein FOC75_29010 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOC75_29020 ENOG41067QW Transcriptional regulator FOC75_29025 ENOG4105CJ3 phosphate transporter FOC75_29030 ENOG41085FC arsR family transcriptional regulator FOC75_29045 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FOC75_29085 ENOG4105C59 p-type ATPase FOC75_29090 ENOG4105VPX protein, conserved in bacteria FOC75_29095 ENOG4105DSE periplasmic solute binding protein FOC75_29125 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding