locus-tag class description FOC91_00100 ENOG4105D7V transposase FOC91_00130 ENOG4105CNU cell division protein FtsK FOC91_00135 ENOG4105EKQ RNA-directed DNA polymerase FOC91_00190 ENOG4105EKQ RNA-directed DNA polymerase FOC91_00250 ENOG4105EKQ RNA-directed DNA polymerase FOC91_00410 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC91_00450 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC91_00570 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC91_00585 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC91_00625 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC91_00640 ENOG4105KRN Transcriptional regulator, abrb family FOC91_00695 ENOG4105K70 DNA-binding protein FOC91_00725 ENOG4105DHF Membrane FOC91_00755 ENOG41086D8 Transcriptional regulator FOC91_00925 ENOG4105C3M thioredoxin reductase FOC91_00945 ENOG4105D6J arsenicaL-resistance protein FOC91_00950 ENOG41082YX Transcriptional regulator, arsr family FOC91_00985 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOC91_01000 ENOG4105CHH sulfate transporter FOC91_01020 ENOG4105CHH sulfate transporter FOC91_01025 ENOG4107YZX Universal stress protein FOC91_01030 ENOG4105CN5 Metallo-Beta-Lactamase FOC91_01040 ENOG4105H3G oxidoreductase FOC91_01045 ENOG4105CAY ferredoxin--nadp reductase FOC91_01050 ENOG41085FC arsR family transcriptional regulator FOC91_01165 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC91_01215 ENOG4105CFF transcriptional regulator FOC91_01285 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC91_01360 ENOG4105CAR Terminase, large subunit FOC91_01435 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC91_01485 ENOG4105CFF transcriptional regulator FOC91_01520 ENOG4106032 Glutathionylspermidine synthase FOC91_01550 ENOG4105KHC sulfurtransferase FOC91_01560 ENOG4108W0I acetyltransferase FOC91_01570 ENOG410890F Dynamin family FOC91_01575 ENOG4105DHF Membrane FOC91_01580 ENOG4105C2W permease FOC91_01590 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC91_01605 ENOG4105CTD carboxy-peptidase FOC91_01610 ENOG4105DVT helicase FOC91_01620 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOC91_01680 ENOG4105BZ4 penicillin-binding protein FOC91_01690 ENOG4105CSM endonuclease III FOC91_01710 ENOG4105YAC FOC91_01715 ENOG4105DVT helicase FOC91_01750 ENOG4105CPK Glycosyl transferase (Group 1 FOC91_01755 ENOG4105FJR Lmbe family FOC91_01770 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FOC91_01775 ENOG4108JYZ YitT family FOC91_01805 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit FOC91_01810 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOC91_01815 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FOC91_01830 ENOG41068YB TPR repeat-containing protein FOC91_01835 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC91_01855 ENOG4105EAH synthase FOC91_01865 ENOG4105XXQ heptaprenyl diphosphate synthase component I FOC91_01880 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FOC91_01910 ENOG41065D1 FOC91_01915 ENOG4105S2F FOC91_01950 ENOG4105HDK L-asparaginase FOC91_01955 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FOC91_01980 ENOG4108S6Z Negative regulator of genetic competence FOC91_01985 ENOG4107X2D transcriptional regulator, merr family FOC91_01990 ENOG4107RGJ metallophosphoesterase FOC91_02000 ENOG4105I7S Abortive infection protein FOC91_02005 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC91_02020 ENOG4108SAX Membrane FOC91_02030 ENOG41063SB peptidase FOC91_02035 ENOG4108WBT adenosyltransferase FOC91_02040 ENOG4105BZU Histidine kinase FOC91_02045 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC91_02050 ENOG4105CRE cytochrome C FOC91_02055 ENOG4107TWT Cytochrome c biogenesis protein FOC91_02065 ENOG4105FE9 pseudouridine synthase FOC91_02075 ENOG4108JIC nucleoside recognition domain protein FOC91_02080 ENOG4105DZ1 carboxypeptidase FOC91_02085 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC91_02120 ENOG4105BZU Histidine kinase FOC91_02135 ENOG4105I3N Conserved Protein FOC91_02140 ENOG4105BZU Histidine kinase FOC91_02155 ENOG4105BZ4 penicillin-binding protein FOC91_02160 ENOG4107GRR phosphate transport regulator FOC91_02165 ENOG4105CJ3 phosphate transporter FOC91_02210 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOC91_02230 ENOG4105WH1 Two component transcriptional regulator luxr family FOC91_02235 ENOG4105ENE Histidine kinase FOC91_02255 ENOG4105DFD Na H antiporter FOC91_02275 ENOG4105C8J )-transporter FOC91_02280 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC91_02285 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC91_02290 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC91_02300 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FOC91_02305 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FOC91_02325 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOC91_02335 ENOG4105E0M Sulfatase FOC91_02340 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC91_02345 ENOG4105C5I Dehydrogenase FOC91_02355 ENOG4107RVV histidinol phosphate phosphatase, hisj family FOC91_02430 ENOG4108ZP8 Acetolactate synthase small subunit FOC91_02435 ENOG4105C7K acetolactate synthase FOC91_02440 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC91_02465 ENOG4105KBJ sporulation protein ytfj FOC91_02470 ENOG41063Y9 FOC91_02475 ENOG4105CZN Potassium uptake protein FOC91_02505 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC91_02510 ENOG4107QMU Mate efflux family protein FOC91_02545 ENOG4105NQC Flavodoxin FOC91_02570 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC91_02580 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC91_02585 ENOG4105EA8 2-Nitropropane dioxygenase FOC91_02590 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC91_02630 ENOG4105CJ1 ABC, transporter FOC91_02640 ENOG4105CZV ABC transporter FOC91_02645 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC91_02650 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC91_02660 ENOG41079K6 HNH endonuclease FOC91_02665 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC91_02670 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOC91_02710 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOC91_02715 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FOC91_02725 ENOG4105BZU Histidine kinase FOC91_02730 ENOG4106DF1 FOC91_02740 ENOG41090MY MarR family Transcriptional regulator FOC91_02745 ENOG4105BZU Histidine kinase FOC91_02755 ENOG4105PXI polysaccharide deacetylase FOC91_02765 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FOC91_02775 ENOG4105E98 transcriptional regulator DeoR family FOC91_02795 ENOG4107RCV ABC transporter, permease FOC91_02800 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC91_02805 ENOG4105C4Y ABC transporter FOC91_02825 ENOG4105MWK D-amino acid dehydrogenase, small subunit FOC91_02835 ENOG4105CHR reductase FOC91_02855 ENOG4108Z7G MaoC domain protein dehydratase FOC91_02860 ENOG410681C small acid-soluble spore protein FOC91_02865 ENOG4105CZN Potassium uptake protein FOC91_02870 ENOG4107TS3 membrane protein, TerC FOC91_02875 ENOG4108QTI )-transporter FOC91_02885 ENOG4106A3R peptidase FOC91_02905 ENOG4105JXH GntR family transcriptional regulator FOC91_02910 ENOG4105BZU Histidine kinase FOC91_02915 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC91_02930 ENOG4105CQB FAD linked oxidase domain protein FOC91_02935 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOC91_02940 ENOG4105K4I Scp-like extracellular FOC91_02950 ENOG4108YBP pseudouridine synthase FOC91_02960 ENOG4105EYF MMPL domain protein FOC91_02970 ENOG4107RUE extracellular solute-binding protein family 1 FOC91_02975 ENOG4105D38 putrescine abc transporter FOC91_02980 ENOG4105F38 ABC transporter, permease FOC91_02990 ENOG4105C26 Dehydrogenase FOC91_03025 ENOG4105VFR signal peptidase FOC91_03030 ENOG4105DZ1 carboxypeptidase FOC91_03055 ENOG41069I7 FOC91_03120 ENOG4105VZ8 Transcriptional regulator FOC91_03130 ENOG4105C7S Dehydrogenase FOC91_03150 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC91_03230 ENOG4105DDQ anthranilate synthase FOC91_03240 ENOG4105CK7 Sodium proline symporter FOC91_03335 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC91_03340 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOC91_03360 ENOG4107TVC Glycosyl transferase, family 2 FOC91_03380 ENOG4105K64 Glycosyl transferase, family 2 FOC91_03400 ENOG4105EMS pseudouridine synthase FOC91_03420 ENOG4105MIX Adenylate cyclase FOC91_03425 ENOG4108Z18 K06886 hemoglobin FOC91_03440 ENOG4105DPN Oligoendopeptidase f FOC91_03450 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC91_03460 ENOG4108ZCF integral membrane protein FOC91_03480 ENOG4105UQX Mate efflux family protein FOC91_03485 ENOG4108JQ7 (ABC) transporter FOC91_03495 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC91_03500 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC91_03515 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC91_03530 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC91_03535 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC91_03560 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC91_03570 ENOG4108KP7 hydrolase FOC91_03580 ENOG41073B9 FOC91_03585 ENOG4107AYK membrAne FOC91_03595 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC91_03605 ENOG4105QNR S1 RNA binding domain protein FOC91_03625 ENOG4105BZU Histidine kinase FOC91_03630 ENOG4105CH6 catalase FOC91_03635 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC91_03640 ENOG4105CAQ asparagine synthetase FOC91_03665 ENOG4105ERH Fumarylacetoacetate hydrolase FOC91_03730 ENOG4105XVF Competence transcription factor FOC91_03760 ENOG4107QP3 malate synthase g FOC91_03785 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FOC91_03810 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC91_03820 ENOG41086D8 Transcriptional regulator FOC91_03825 ENOG4108AEY RNA polymerase sigma factor FOC91_03835 ENOG4107TVP HD domain protein FOC91_03845 ENOG4107RN3 metallophosphoesterase FOC91_03850 ENOG4105ENX hydrolase FOC91_03910 ENOG4105CEY Amp-dependent synthetase and ligase FOC91_03920 ENOG4105DF9 Lipoate-protein, ligase FOC91_03925 ENOG4108RQ5 Beta-lactamase domain-containing protein FOC91_03930 ENOG4106AXD FOC91_03960 ENOG4105ECB domain protein FOC91_03975 ENOG4105NA0 Transcriptional regulator FOC91_04000 ENOG4105C1Q protoporphyrinogen oxidase FOC91_04015 ENOG4105BZ4 penicillin-binding protein FOC91_04020 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FOC91_04025 ENOG4105CKV Membrane FOC91_04030 ENOG410905X membrane-flanked domain protein FOC91_04080 ENOG4105CKV Membrane FOC91_04085 ENOG410905X membrane-flanked domain protein FOC91_04170 ENOG4105K59 histidine triad (HIT) protein FOC91_04195 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC91_04200 ENOG4105EEM helicase FOC91_04210 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC91_04215 ENOG4105C57 major facilitator superfamily FOC91_04240 ENOG4105EMN RNA polymerase sigma factor FOC91_04260 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOC91_04275 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC91_04295 ENOG4108MUZ hydrolase FOC91_04350 ENOG4106D4I domain protein FOC91_04355 ENOG4107VRP DNA repair exonuclease FOC91_04380 ENOG4108VB1 regulatoR FOC91_04385 ENOG4105ENE Histidine kinase FOC91_04425 ENOG4105BZU Histidine kinase FOC91_04430 ENOG4105BZU Histidine kinase FOC91_04435 ENOG4108MJI response regulator FOC91_04445 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC91_04455 ENOG4105WN5 stage II sporulation protein FOC91_04520 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOC91_04530 ENOG410780I phosphoprotein phosphatase activity FOC91_04545 ENOG410847I Transcriptional regulator, BadM Rrf2 family FOC91_04550 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC91_04555 ENOG4105CMT Dihydroxyacetone kinase FOC91_04565 ENOG4105CMT Dihydroxyacetone kinase FOC91_04570 ENOG4108NIW Leucine export protein LeuE FOC91_04625 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC91_04640 ENOG4108IG5 Transcriptional regulator FOC91_04645 ENOG4107P5I polyketide synthase FOC91_04730 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 FOC91_04740 ENOG4105CDU Replicative dna helicase FOC91_04800 ENOG4108MRH transcriptional regulatory protein FOC91_04810 ENOG4105CSH Transporter FOC91_04830 ENOG4105CTU Proline racemase FOC91_04850 ENOG4105DER m42 family FOC91_04870 ENOG4105CGU Enoyl-CoA hydratase FOC91_04880 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC91_04890 ENOG4106AKK s-layer domain-containing protein FOC91_04935 ENOG4105CHH sulfate transporter FOC91_04950 ENOG4105D4P Coproporphyrinogen iii oxidase FOC91_04955 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC91_04970 ENOG4107FQX Alpha-acetolactate decarboxylase FOC91_05020 ENOG4105BZU Histidine kinase FOC91_05045 ENOG410839P FOC91_05060 ENOG4105CDA abc transporter atp-binding protein FOC91_05065 ENOG4105DRP amino acid AbC transporter FOC91_05075 ENOG4105BZ1 (ABC) transporter FOC91_05080 ENOG4105BZ1 (ABC) transporter FOC91_05085 ENOG4105C26 Dehydrogenase FOC91_05095 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOC91_05100 ENOG4105D5Q Arginine ornithine antiporter FOC91_05110 ENOG4105CH6 catalase FOC91_05115 ENOG4107RKG DJ-1/PfpI family FOC91_05125 ENOG4105E5W Transporter FOC91_05130 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC91_05145 ENOG4105KPY Small multidrug resistance protein FOC91_05160 ENOG4108YXU transcriptional regulator AsnC family FOC91_05205 ENOG4106KNT transcriptional regulator FOC91_05215 ENOG4107RWR Sodium hydrogen exchanger FOC91_05220 ENOG4105CUB amino acid FOC91_05255 ENOG4107T5V SNARE associated Golgi FOC91_05290 ENOG4105WEF catalase FOC91_05325 ENOG4105C19 ABC transporter FOC91_05330 ENOG4107RBB ABC transporter, permease FOC91_05335 ENOG41069ER domain protein FOC91_05355 ENOG4105VZJ PTS System FOC91_05360 ENOG4105VCP PTS System FOC91_05365 ENOG4105EMD TRANSCRIPTIONal FOC91_05390 ENOG4108KGH TRANSCRIPTIONal FOC91_05400 ENOG41087NI Sulfite exporter TauE/SafE FOC91_05405 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FOC91_05415 ENOG41085GJ domain protein FOC91_05420 ENOG4105VFE sira family FOC91_05425 ENOG4107TPS domain protein FOC91_05430 ENOG4105VFE sira family FOC91_05435 ENOG4105XTG Pfam:DUF156 FOC91_05440 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FOC91_05485 ENOG4105ED1 spovr family FOC91_05490 ENOG4107Y03 Nitroreductase FOC91_05510 ENOG4108B31 Spore germination protein FOC91_05545 ENOG4105C5Y PTS System FOC91_05565 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC91_05575 ENOG4105C7N Xanthine uracil vitamin C permease FOC91_05585 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC91_05610 ENOG4108INS Transcriptional regulator FOC91_05660 ENOG4105DWF phosphomethylpyrimidine kinase FOC91_05665 ENOG4105D06 uba thif-type nad fad binding protein FOC91_05680 ENOG41080HI glycine oxidase FOC91_05685 ENOG4108VEU Thiamine monophosphate synthase FOC91_05695 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC91_05705 ENOG4105ETU transcriptional activator (TenA FOC91_05725 ENOG41080XQ Signal transduction protein with cbs domains FOC91_05855 ENOG4105E2Z phosphate ABC transporter (Permease FOC91_05860 ENOG4105C8U phosphate abc transporter FOC91_05865 ENOG4105CVA phosphate FOC91_05870 ENOG4105CE1 Ferrous iron transport protein b FOC91_05875 ENOG4105CE1 Ferrous iron transport protein b FOC91_05880 ENOG4105CE1 Ferrous iron transport protein b FOC91_05885 ENOG4108NHD germination protein FOC91_05900 ENOG4105E1V na solute symporter FOC91_05905 ENOG4106CAD Protein of unknown function (DUF3311) FOC91_05920 ENOG4105E2S oxidase) subunit II FOC91_05925 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC91_05950 ENOG4105MA6 gCN5-related N-acetyltransferase FOC91_05965 ENOG4105C7N Xanthine uracil vitamin C permease FOC91_05970 ENOG4105C85 amino acid FOC91_05990 ENOG4105DUX Transporter FOC91_06000 ENOG4107D63 FOC91_06005 ENOG4105VZ8 Transcriptional regulator FOC91_06010 ENOG41069ER domain protein FOC91_06015 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC91_06080 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOC91_06085 ENOG4105CNN ABC, transporter FOC91_06100 ENOG4108RVA ribokinase FOC91_06105 ENOG4105ETE Transcriptional regulator (LacI family FOC91_06110 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC91_06115 ENOG41067TZ transcriptional regulator, MarR family FOC91_06120 ENOG4105CXY transporter FOC91_06130 ENOG4108JQ7 (ABC) transporter FOC91_06135 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC91_06145 ENOG4105DEF Extracellular solute-binding protein, family 5 FOC91_06155 ENOG41068KF Universal stress protein FOC91_06160 ENOG4105CHH sulfate transporter FOC91_06170 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC91_06175 ENOG4105BZU Histidine kinase FOC91_06180 ENOG4105NAE bifunctional deaminase-reductase domain protein FOC91_06185 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC91_06210 ENOG4108IQI permease FOC91_06215 ENOG4105DRP amino acid AbC transporter FOC91_06220 ENOG4105EAD ABC transporter FOC91_06225 ENOG4105CT1 (ABC) transporter FOC91_06230 ENOG4105CDA abc transporter atp-binding protein FOC91_06235 ENOG4105BZG amino acid carrier protein FOC91_06240 ENOG4105CRN Aminoglycoside phosphotransferase FOC91_06255 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC91_06260 ENOG4105WH1 Two component transcriptional regulator luxr family FOC91_06265 ENOG4108XG2 Histidine kinase FOC91_06270 ENOG4105E1K spore germination protein FOC91_06285 ENOG4105CG3 alpha amylase, catalytic region FOC91_06290 ENOG4105C5Y PTS System FOC91_06295 ENOG4107414 GntR family transcriptional regulator FOC91_06300 ENOG4105D5Q Arginine ornithine antiporter FOC91_06305 ENOG4105BZU Histidine kinase FOC91_06315 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC91_06320 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FOC91_06325 ENOG4107T89 von Willebrand factor, type A FOC91_06335 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FOC91_06340 ENOG4105EXW epimerase dehydratase FOC91_06350 ENOG4105DMQ Methyltransferase FOC91_06355 ENOG4105E0A ABC, transporter FOC91_06360 ENOG4108IHU transport system permease protein FOC91_06365 ENOG4105DQ5 transport system permease protein FOC91_06370 ENOG4108MES Periplasmic binding protein FOC91_06375 ENOG4105DUX Transporter FOC91_06390 ENOG4105DAA L-lactate FOC91_06395 ENOG4108IJ0 Aspartate ammonia-lyase FOC91_06400 ENOG4105C37 (CBS) domain FOC91_06405 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOC91_06410 ENOG4105D9N nucleoside FOC91_06415 ENOG4108KGH TRANSCRIPTIONal FOC91_06420 ENOG41073R8 VanW family FOC91_06455 ENOG4105DAP Nicotinate phosphoribosyltransferase FOC91_06460 ENOG4105C59 p-type ATPase FOC91_06470 ENOG4105CUB amino acid FOC91_06490 ENOG4108JB9 formate dehydrogenase FOC91_06495 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC91_06500 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC91_06505 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC91_06510 ENOG4105BZU Histidine kinase FOC91_06520 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC91_06525 ENOG4108UZ3 Transporter FOC91_06535 ENOG4105C6K Malic enzyme FOC91_06545 ENOG4108MRH transcriptional regulatory protein FOC91_06570 ENOG4105US7 Histidine kinase FOC91_06575 ENOG4108STX response regulator FOC91_06580 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOC91_06585 ENOG4105BZ7 extracellular solute-binding protein family 1 FOC91_06590 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FOC91_06595 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOC91_06600 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC91_06605 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC91_06625 ENOG4105D4T Citrate transporter FOC91_06630 ENOG4108V9W transcriptional regulatory protein FOC91_06635 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOC91_06645 ENOG4105DZ6 Band 7 protein FOC91_06660 ENOG4105C94 Transporter FOC91_06680 ENOG4105CYN Serine protein kinase FOC91_06690 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOC91_06700 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOC91_06710 ENOG4107ZQN disulfide bond FOC91_06715 ENOG4108JQC penicillin-binding protein 1A FOC91_06745 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC91_06880 ENOG4105G5W regulator Fur family FOC91_06885 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC91_06905 ENOG4108IUW ABC transporter FOC91_06915 ENOG4105CBC glutamate synthase FOC91_06920 ENOG4107NBY Membrane FOC91_06925 ENOG4105BZ1 (ABC) transporter FOC91_06945 ENOG4106BXE FOC91_06950 ENOG4105CEN a g-specific adenine glycosylase FOC91_06955 ENOG41067AE Membrane-bound metal-dependent hydrolase FOC91_06985 ENOG4105ECP epimerase FOC91_06990 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC91_07010 ENOG4105F1A Pyruvate formate-lyase FOC91_07030 ENOG4105C3I Nad-dependent epimerase dehydratase FOC91_07035 ENOG4107QQG Dehydrogenase FOC91_07040 ENOG4105CKK Glycosyl transferase, family 2 FOC91_07055 ENOG4108A04 Beta-lactamase FOC91_07150 ENOG4105UPD Calcium Proton FOC91_07155 ENOG410606W general stress protein FOC91_07170 ENOG4107ZTW SNARE associated Golgi FOC91_07190 ENOG4108IPJ Membrane FOC91_07195 ENOG4105C59 p-type ATPase FOC91_07200 ENOG4107U9T Pfam:Ribonuclease_BN FOC91_07210 ENOG4105KJF protein tyrosine phosphatase FOC91_07230 ENOG4108TTB tellurium resistance protein FOC91_07235 ENOG4107TS3 membrane protein, TerC FOC91_07240 ENOG4106FN3 tellurium resistance protein FOC91_07245 ENOG4106FN3 tellurium resistance protein FOC91_07250 ENOG4108N0M stress protein FOC91_07280 ENOG4105DEU major facilitator superfamily FOC91_07300 ENOG41062JF Transcriptional regulator FOC91_07330 ENOG4105C5H ABC transporter FOC91_07350 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC91_07365 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FOC91_07395 ENOG4105CI1 PTS System FOC91_07405 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC91_07410 ENOG4105C8Q Methyl-accepting chemotaxis FOC91_07420 ENOG4105EAB amino acid AbC transporter FOC91_07425 ENOG4105E5Q amino acid AbC transporter FOC91_07430 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOC91_07440 ENOG4107QJZ Glycosyl transferase, family 2 FOC91_07455 ENOG4105D2S major facilitator superfamily FOC91_07460 ENOG410756H nucleotidyltransferase FOC91_07480 ENOG4105BZU Histidine kinase FOC91_07500 ENOG4106UIA FOC91_07505 ENOG4106UIA FOC91_07525 ENOG4108V5C ABC transporter FOC91_07530 ENOG4105DQ5 transport system permease protein FOC91_07535 ENOG4105EHG Permease protein FOC91_07560 ENOG4105D3R alkyl hydroperoxide reductase FOC91_07580 ENOG4105DFD Na H antiporter FOC91_07590 ENOG4105DTQ mandelate racemase muconate lactonizing FOC91_07605 ENOG4108W15 Protein of unknown function (DUF1456) FOC91_07610 ENOG4105BZU Histidine kinase FOC91_07620 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC91_07625 ENOG4105D9N nucleoside FOC91_07645 ENOG4105KPY Small multidrug resistance protein FOC91_07650 ENOG4105C26 Dehydrogenase FOC91_07660 ENOG4108JPW Aminotransferase FOC91_07665 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC91_07670 ENOG4105CBD Diacylglycerol kinase FOC91_07690 ENOG4107I77 yiaA/B two helix domain FOC91_07695 ENOG410834F Transcriptional regulator FOC91_07715 ENOG4105D01 (LipO)protein FOC91_07720 ENOG4108UMI ABC transporter, permease FOC91_07725 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC91_07730 ENOG4108W2Y isochorismatase FOC91_07760 ENOG4105C4R Atp-dependent dna helicase FOC91_07785 ENOG4105C12 Phosphoribosylglycinamide synthetase FOC91_07795 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOC91_07820 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FOC91_07830 ENOG4105C83 adenylosuccinate lyase FOC91_07835 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOC91_07840 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOC91_07865 ENOG4105SX7 Transporter FOC91_07885 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC91_07960 ENOG4107ZXU DSBA oxidoreductase FOC91_07985 ENOG4105BZU Histidine kinase FOC91_07995 ENOG4105C7N Xanthine uracil vitamin C permease FOC91_08010 ENOG4107EV6 Inherit from COG: YD repeat protein FOC91_08025 ENOG4108TYN CAAX amino terminal protease family protein FOC91_08040 ENOG4105C5H ABC transporter FOC91_08050 ENOG410801F ribosomal-protein-alanine acetyltransferase FOC91_08055 ENOG41072GX Peptidase M22 Glycoprotease FOC91_08060 ENOG4105K8N protein family UPF0079, ATPase FOC91_08160 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FOC91_08170 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC91_08175 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FOC91_08185 ENOG4107ZXI Rhomboid family FOC91_08200 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOC91_08205 ENOG4105CPF Cell wall formation (By similarity) FOC91_08210 ENOG4108SC4 )-transporter FOC91_08220 ENOG4105ERH Fumarylacetoacetate hydrolase FOC91_08225 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FOC91_08255 ENOG410667J hydrolase FOC91_08260 ENOG4108JQ7 (ABC) transporter FOC91_08265 ENOG4105C3U ABC transporter FOC91_08270 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC91_08280 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FOC91_08295 ENOG4105C5H ABC transporter FOC91_08320 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FOC91_08330 ENOG4108RE7 deoxyribonuclease FOC91_08340 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC91_08360 ENOG4105F6E Acyl-transferase FOC91_08390 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FOC91_08395 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC91_08400 ENOG4105E0C molybdate abc transporter FOC91_08410 ENOG4107XDY Nicotinamide Mononucleotide Transporter FOC91_08415 ENOG4105II7 pyrroline-5-carboxylate reductase FOC91_08425 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC91_08430 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC91_08460 ENOG4108JQ7 (ABC) transporter FOC91_08465 ENOG4105C3U ABC transporter FOC91_08470 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC91_08475 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC91_08490 ENOG4105C2C drug resistance transporter, Bcr CflA FOC91_08505 ENOG4105IQ5 FAD linked oxidase domain protein FOC91_08520 ENOG4105D01 (LipO)protein FOC91_08525 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC91_08530 ENOG4108UMI ABC transporter, permease FOC91_08570 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FOC91_08580 ENOG4105CMG Carbohydrate kinase FOC91_08615 ENOG4107U5W ybbr family FOC91_08620 ENOG4105C8B TIGR00159 family FOC91_08700 ENOG4108NMV polysaccharide deacetylase FOC91_08715 ENOG4105D1F ATP-binding protein FOC91_08745 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC91_08790 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC91_08800 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC91_08930 ENOG4105XPM ribosomal protein FOC91_08945 ENOG4107Y49 methyltransferase FOC91_08970 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOC91_08985 ENOG4105QIV RNA polymerase FOC91_08990 ENOG4105M0M Tetracycline resistance protein FOC91_08995 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOC91_09010 ENOG4105D7W serine acetyltransferase FOC91_09030 ENOG4105CTP PilT protein domain protein FOC91_09040 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOC91_09055 ENOG4108Z0C Uvrb UvrC protein FOC91_09145 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC91_09155 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOC91_09160 ENOG4105KRF dihydroneopterin aldolase FOC91_09165 ENOG4105EEI dihydropteroate synthase FOC91_09170 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FOC91_09175 ENOG4105DDQ anthranilate synthase FOC91_09180 ENOG4105CRQ synthase (Component I) FOC91_09185 ENOG4105C6T cysteine synthase FOC91_09200 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC91_09205 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC91_09230 ENOG41060GV RNA binding s1 domain protein FOC91_09245 ENOG4105VYY sporulation protein yabp FOC91_09250 ENOG41082I2 s4 domain protein FOC91_09255 ENOG4108IY2 MazG family FOC91_09265 ENOG4108M14 stage v sporulation protein t FOC91_09270 ENOG4108JA2 transcriptioN-repair coupling factor FOC91_09300 ENOG4105KME endoribonuclease L-psp FOC91_09305 ENOG4105DFT pur operon repressor FOC91_09320 ENOG4105W42 Veg protein FOC91_09325 ENOG4105XFA sporulation peptidase YabG FOC91_09335 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FOC91_09340 ENOG4105F8V Hydrolase, tatD family FOC91_09350 ENOG4105KRN Transcriptional regulator, abrb family FOC91_09355 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOC91_09365 ENOG41060K3 Methyltransferase FOC91_09375 ENOG4105MA4 psp1 domain protein FOC91_09380 ENOG4105FA2 dna polymerase iii FOC91_09390 ENOG4105CXN decarboxylase FOC91_09425 ENOG41067KS pro-sigma K processing FOC91_09445 ENOG4105C6E dna polymerase iii FOC91_09455 ENOG4108Z6B deaminase FOC91_09460 ENOG4105GTG Isochorismatase FOC91_09470 ENOG4105ZMH deoxynucleoside kinase FOC91_09505 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOC91_09540 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC91_09555 ENOG410848D S4 domain protein YaaA FOC91_09560 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC91_09580 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC91_09610 ENOG4107QJE Chromosome Partitioning Protein FOC91_09615 ENOG4105FA0 parb-like partition protein FOC91_09620 ENOG4108ZDA Sporulation protein YyaC FOC91_09625 ENOG4105D8X mechanosensitive ion channel FOC91_09630 ENOG4105VDK protein, conserved in bacteria FOC91_09635 ENOG4105C3G gtp-binding protein FOC91_09645 ENOG4108UUM single-stranded DNA-binding protein FOC91_09655 ENOG4108XMW Membrane FOC91_09660 ENOG4105BZR domain protein FOC91_09670 ENOG4105CDU Replicative dna helicase FOC91_09700 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC91_09705 ENOG4105BZU Histidine kinase FOC91_09720 ENOG4105Q2H domain protein FOC91_09725 ENOG4105C0H protease FOC91_09745 ENOG4105DPN Oligoendopeptidase f FOC91_09760 ENOG4105C1J atp-dependent rna helicase FOC91_09770 ENOG4108UT2 hemolysin iii FOC91_09775 ENOG4105CMR udp-glucose 4-epimerase FOC91_09785 ENOG4105IW1 AmiS UreI transporter FOC91_09795 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC91_09810 ENOG4107RGD Major Facilitator superfamily FOC91_09815 ENOG4108HRK Histidine kinase FOC91_09820 ENOG4105DY9 regulatoR FOC91_09835 ENOG4106F5Q Membrane FOC91_09840 ENOG4105E0X reductase FOC91_09850 ENOG41067SE Tetr family transcriptional regulator FOC91_09855 ENOG4105CKK Glycosyl transferase, family 2 FOC91_09875 ENOG4105C5H ABC transporter FOC91_09880 ENOG4105JEU Glycosyl transferase, family 2 FOC91_09890 ENOG4108S4H thioesterase Superfamily protein FOC91_09900 ENOG4106YBV Methyl-accepting chemotaxis FOC91_09905 ENOG4105EN6 Membrane FOC91_09925 ENOG41079KZ Major Facilitator Superfamily FOC91_09930 ENOG4105DY9 regulatoR FOC91_09935 ENOG4105D22 carbon starvation protein FOC91_09940 ENOG4105VCD cytoplasmic protein FOC91_09945 ENOG4105BZU Histidine kinase FOC91_09950 ENOG4105DWF phosphomethylpyrimidine kinase FOC91_09955 ENOG4105BZU Histidine kinase FOC91_09960 ENOG4105WH1 Two component transcriptional regulator luxr family FOC91_09970 ENOG4108Y4K DNA-binding transcriptional activator FOC91_09975 ENOG4105D7V transposase FOC91_10000 ENOG4105D6E homoserine dehydrogenase FOC91_10015 ENOG41090WU lipolytic protein G-D-S-L family FOC91_10020 ENOG4105CJ1 ABC, transporter FOC91_10025 ENOG4108TU7 Inherit from COG: (ABC) transporter FOC91_10035 ENOG4105VCH membrane FOC91_10040 ENOG410667J hydrolase FOC91_10050 ENOG4107SVH Potassium channel protein FOC91_10070 ENOG4108VKI Cell wall hydrolase FOC91_10085 ENOG4108IJ2 phosphate acetyltransferase FOC91_10100 ENOG4108VCI transcription factor, rsfa family FOC91_10110 ENOG4105DQ5 transport system permease protein FOC91_10115 ENOG4105EHG Permease protein FOC91_10120 ENOG4105E0A ABC, transporter FOC91_10125 ENOG4108MES Periplasmic binding protein FOC91_10130 ENOG4105DCI Phosphohydrolase FOC91_10135 ENOG41069HH 4-oxalocrotonate tautomerase FOC91_10140 ENOG4108Z4T Peptidase M50 FOC91_10145 ENOG4108XFG YwhD family FOC91_10150 ENOG4105BZ4 penicillin-binding protein FOC91_10155 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC91_10160 ENOG4107SWG transcriptional regulator MERR family FOC91_10165 ENOG4105DXB Major Facilitator superfamily FOC91_10175 ENOG4105CYW agmatinase FOC91_10195 ENOG410684U Domain of unknown function (DUF1934) FOC91_10205 ENOG4105EMN RNA polymerase sigma factor FOC91_10225 ENOG4105IIU Aminopeptidase FOC91_10235 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FOC91_10240 ENOG4108M15 ABC transporter FOC91_10245 ENOG4105KCT ABC transporter FOC91_10250 ENOG4105BZU Histidine kinase FOC91_10275 ENOG4105BZU Histidine kinase FOC91_10290 ENOG4105DF6 Fe-S oxidoreductase FOC91_10300 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC91_10305 ENOG4105C1G acyl-Coa dehydrogenase FOC91_10310 ENOG4105C1G acyl-Coa dehydrogenase FOC91_10350 ENOG4105CBT Fructose-1,6-bisphosphatase FOC91_10355 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOC91_10375 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC91_10380 ENOG4108ZXQ stage ii sporulation protein r FOC91_10390 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC91_10410 ENOG4107XC4 flavin reductase domain protein, FMN-binding FOC91_10415 ENOG4108VGI doxx family FOC91_10430 ENOG4108YZG isomerase FOC91_10460 ENOG41062M3 atp synthase FOC91_10465 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FOC91_10515 ENOG4105BZU Histidine kinase FOC91_10530 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC91_10535 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC91_10560 ENOG4105D65 subunit l FOC91_10565 ENOG4105C8S subunit m FOC91_10570 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC91_10575 ENOG4106778 Protein of unknown function (DUF1146) FOC91_10595 ENOG4105DY9 regulatoR FOC91_10610 ENOG4105FRN stage II sporulation protein FOC91_10620 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FOC91_10635 ENOG4107YJ4 chain length determinant protein FOC91_10640 ENOG4105HTX biosynthesis protein FOC91_10645 ENOG4107YJ4 chain length determinant protein FOC91_10650 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FOC91_10655 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC91_10665 ENOG4105C30 Nad-dependent epimerase dehydratase FOC91_10670 ENOG4105C0K Gdp-mannose 4,6-dehydratase FOC91_10690 ENOG4105CPK Glycosyl transferase (Group 1 FOC91_10695 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase FOC91_10700 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family FOC91_10705 ENOG4105CJT Mannose-1-phosphate guanylyltransferase FOC91_10715 ENOG4105DG6 mannose-6-phosphate isomerase FOC91_10720 ENOG4108KGH TRANSCRIPTIONal FOC91_10730 ENOG4105CMR udp-glucose 4-epimerase FOC91_10740 ENOG4105DM4 PTS System FOC91_10745 ENOG4105DG6 mannose-6-phosphate isomerase FOC91_10750 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC91_10770 ENOG4105CXY transporter FOC91_10790 ENOG4105C19 ABC transporter FOC91_10795 ENOG4107RBB ABC transporter, permease FOC91_10810 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC91_10840 ENOG4105C0D helicase FOC91_10845 ENOG4105KBK Zinc finger, swim domain protein FOC91_10870 ENOG41069ER domain protein FOC91_10875 ENOG4105C94 Transporter FOC91_10880 ENOG4107R8N Glycosyl transferase, family 2 FOC91_10905 ENOG4105E0M Sulfatase FOC91_10915 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FOC91_10925 ENOG4105D7V transposase FOC91_10930 ENOG4105DAA L-lactate FOC91_10965 ENOG4107RSM transcriptional regulator FOC91_10970 ENOG4105ECB domain protein FOC91_10990 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FOC91_11005 ENOG4105VZJ PTS System FOC91_11015 ENOG4105VCP PTS System FOC91_11035 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FOC91_11045 ENOG4105CK1 PTS System FOC91_11050 ENOG4105VCP PTS System FOC91_11055 ENOG4105F8D glycoside hydrolase family 4 FOC91_11075 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC91_11085 ENOG4105ESV Glycosyl transferase, family 4 FOC91_11090 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOC91_11095 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC91_11100 ENOG4108KGH TRANSCRIPTIONal FOC91_11105 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOC91_11115 ENOG4105KVH Transcriptional regulator FOC91_11130 ENOG41081UC Inherit from COG: Competence protein FOC91_11135 ENOG4105VEQ Cold shock protein FOC91_11140 ENOG4105MS2 ribosomal subunit Interface protein FOC91_11160 ENOG4105CAK Cell division ATP-binding protein ftsE FOC91_11165 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOC91_11170 ENOG4105CN1 protease FOC91_11180 ENOG4105BZ1 (ABC) transporter FOC91_11190 ENOG4105C5H ABC transporter FOC91_11195 ENOG4108WS4 fmn reductase FOC91_11205 ENOG4105DUM transcriptional regulator, lysR family FOC91_11210 ENOG4105HMI Membrane FOC91_11235 ENOG4107TXC Transcriptional regulator FOC91_11250 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOC91_11255 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC91_11265 ENOG41086DT Membrane protein of unknown function FOC91_11285 ENOG4108S4C acetyltransferase FOC91_11295 ENOG4105C3M thioredoxin reductase FOC91_11305 ENOG4108Z4K mutator MutT protein FOC91_11315 ENOG4105CHW UPF0052 protein FOC91_11325 ENOG4105KRI phosphocarrier protein (HPr FOC91_11335 ENOG4105H67 Protein of unknown function (DUF421) FOC91_11350 ENOG4105CZ3 stage V sporulation protein ad FOC91_11355 ENOG41090VF Stage v sporulation protein ac FOC91_11375 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC91_11425 ENOG41067MG lrgb family FOC91_11430 ENOG4105XZU Preprotein translocase, subunit SecG FOC91_11440 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOC91_11455 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC91_11470 ENOG4105CM4 permease protein FOC91_11475 ENOG4108IPW abc transporter atp-binding protein FOC91_11495 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC91_11500 ENOG4105C5H ABC transporter FOC91_11525 ENOG4105WMR Protein CrcB homolog FOC91_11535 ENOG4105C8Q Methyl-accepting chemotaxis FOC91_11550 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC91_11565 ENOG4105KVH Transcriptional regulator FOC91_11570 ENOG4105F27 Major Facilitator FOC91_11575 ENOG4105CV8 reductase FOC91_11590 ENOG4108RYK Nad-dependent epimerase dehydratase FOC91_11605 ENOG4105D9N nucleoside FOC91_11610 ENOG4105D9N nucleoside FOC91_11630 ENOG4108URH decarboxylase FOC91_11645 ENOG4108RMU ferritin dps family protein FOC91_11655 ENOG4105NCW Trka-c domain protein FOC91_11660 ENOG4107S91 Sodium hydrogen exchanger FOC91_11680 ENOG4105D4Y metalloprotease FOC91_11685 ENOG4105VG1 fes assembly suf system protein FOC91_11690 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC91_11695 ENOG4105C8Q Methyl-accepting chemotaxis FOC91_11715 ENOG4105BZU Histidine kinase FOC91_11720 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC91_11725 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC91_11735 ENOG4107ZTW SNARE associated Golgi FOC91_11770 ENOG4107AYK membrAne FOC91_11780 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC91_11795 ENOG4107R7I amino acid FOC91_11800 ENOG4108SUT Major Facilitator Superfamily FOC91_11820 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC91_11840 ENOG4105DZ1 carboxypeptidase FOC91_11855 ENOG4105CHU acetyl-coa acetyltransferase FOC91_11860 ENOG4105C1G acyl-Coa dehydrogenase FOC91_11885 ENOG4108IUW ABC transporter FOC91_11895 ENOG4108W8B Beta-lactamase domain protein FOC91_11920 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC91_11965 ENOG41080E8 Transcriptional regulator, Spx MgsR family FOC91_11995 ENOG4108UMI ABC transporter, permease FOC91_12000 ENOG4105D01 (LipO)protein FOC91_12005 ENOG4105D01 (LipO)protein FOC91_12010 ENOG4105C3K feS assembly ATPase SufC FOC91_12015 ENOG4105JRK feS assembly protein SufD FOC91_12020 ENOG4105C9B Cysteine desulfurase FOC91_12025 ENOG4108UNV SUF system FeS assembly protein, NifU family FOC91_12030 ENOG4105DIW FeS assembly protein SUFB FOC91_12045 ENOG4107R8B 5'-nucleotidase FOC91_12050 ENOG4105KZD Domain of unknown function (DUF1805) FOC91_12060 ENOG4105FAA peptidase M23 FOC91_12085 ENOG41090T1 Membrane FOC91_12090 ENOG4107TXC Transcriptional regulator FOC91_12095 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FOC91_12100 ENOG4105MMD transcriptional regulator FOC91_12115 ENOG4105CBT Fructose-1,6-bisphosphatase FOC91_12130 ENOG4105D4U had-superfamily hydrolase, subfamily iia FOC91_12135 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC91_12140 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC91_12155 ENOG4108W5N phosphatidylglycerophosphatase a FOC91_12170 ENOG41083MR nifu domain-containing protein FOC91_12195 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOC91_12200 ENOG4105C4B ABC transporter, permease FOC91_12205 ENOG4108JJA ABC, transporter FOC91_12230 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOC91_12245 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FOC91_12470 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC91_12495 ENOG4105EWC Purine nucleoside phosphorylase FOC91_12525 ENOG4105CEP NADH dehydrogenase FOC91_12540 ENOG41069ER domain protein FOC91_12560 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC91_12575 ENOG4105KA0 thioesterase Superfamily protein FOC91_12595 ENOG4107R3E Citrate transporter FOC91_12605 ENOG4105Y38 Kinase-associated protein B FOC91_12620 ENOG4105C87 Aminotransferase class I and II FOC91_12630 ENOG4108MUZ hydrolase FOC91_12635 ENOG4105C5I Dehydrogenase FOC91_12640 ENOG4108ZB6 transcriptional regulator AsnC family FOC91_12645 ENOG4105CHM Aminotransferase FOC91_12655 ENOG4105WG9 Conserved Protein FOC91_12670 ENOG4107PBV potassium channel FOC91_12675 ENOG4105KT7 mgtC SapB transporter FOC91_12710 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOC91_12810 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC91_12855 ENOG4105VEQ Cold shock protein FOC91_12865 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC91_12870 ENOG4105E4F Isochorismate synthase FOC91_12880 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FOC91_12885 ENOG4108IPT Naphthoate synthase FOC91_12895 ENOG4105DTQ mandelate racemase muconate lactonizing FOC91_12915 ENOG41069H0 dihydroorotase EC 3.5.2.3 FOC91_12940 ENOG4105C6Z Gluconate FOC91_12980 ENOG41086D8 Transcriptional regulator FOC91_12985 ENOG4105C19 ABC transporter FOC91_13000 ENOG4107ZTW SNARE associated Golgi FOC91_13020 ENOG4105D7V transposase FOC91_13030 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FOC91_13035 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC91_13060 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC91_13065 ENOG4105BZU Histidine kinase FOC91_13070 ENOG4105N67 Proton-coupled thiamine transporter YuaJ FOC91_13135 ENOG41087YS Phage shock protein A FOC91_13180 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC91_13185 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC91_13190 ENOG4108V2W Carbonate dehydratase FOC91_13245 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOC91_13255 ENOG4105D2X ABC transporter substrate-binding protein FOC91_13270 ENOG4107T7U Sulfatase FOC91_13275 ENOG4107S9D Alpha beta hydrolase FOC91_13280 ENOG4105BZU Histidine kinase FOC91_13285 ENOG4105BZU Histidine kinase FOC91_13295 ENOG4105E98 transcriptional regulator DeoR family FOC91_13300 ENOG4107XGZ Hydrolase FOC91_13365 ENOG4108RIR Molybdenum cofactor biosynthesis protein FOC91_13375 ENOG4105BZF Glycosyl transferase (Group 1 FOC91_13380 ENOG4105YVM Phosphoesterase, PA-phosphatase related FOC91_13385 ENOG4108Z0R Transferase FOC91_13390 ENOG4105E8V Alpha Beta Hydrolase Fold protein FOC91_13435 ENOG4105CIG ABC transporter FOC91_13445 ENOG4105N5T Radical SAM Protein FOC91_13465 ENOG4105C19 ABC transporter FOC91_13480 ENOG4105NCW Trka-c domain protein FOC91_13485 ENOG4107S91 Sodium hydrogen exchanger FOC91_13490 ENOG410605W Major Facilitator FOC91_13525 ENOG4108B31 Spore germination protein FOC91_13535 ENOG4105DWV Homoserine O-trans-acetylase FOC91_13545 ENOG41085GJ domain protein FOC91_13565 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC91_13570 ENOG4105D06 uba thif-type nad fad binding protein FOC91_13580 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC91_13585 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FOC91_13590 ENOG4108ZAF Molybdopterin FOC91_13610 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC91_13615 ENOG4108VJ1 Transcriptional regulator (CarD family FOC91_13650 ENOG4105CBX hi0933 family FOC91_13665 ENOG4105YW5 deoR family transcriptional regulator FOC91_13670 ENOG4107QSE Dipeptidase FOC91_13680 ENOG4108IUM Glycogen debranching enzyme FOC91_13685 ENOG4108V15 phosphotransferase enzyme family FOC91_13700 ENOG4105C8F Beta-lactamase domain protein FOC91_13730 ENOG4108VDD TRNA binding domain protein FOC91_13760 ENOG4105K7K Transcriptional regulator FOC91_13805 ENOG4105C88 aminopeptidase FOC91_13825 ENOG4105ETE Transcriptional regulator (LacI family FOC91_13855 ENOG4105EP9 oxidoreductase FOC91_13860 ENOG4107SNB ankyrin repeat protein YahD FOC91_13865 ENOG4105BZU Histidine kinase FOC91_13870 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC91_13885 ENOG4105DGU Histone deacetylase FOC91_13890 ENOG4105W87 Cbs domain FOC91_13895 ENOG4105F1V Acetoin utilization protein FOC91_13910 ENOG4105EMN RNA polymerase sigma factor FOC91_13940 ENOG4105C28 cystathionine FOC91_13950 ENOG4105U5Y Transcriptional regulator FOC91_13960 ENOG4106KR7 LysR family Transcriptional regulator FOC91_13985 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC91_13995 ENOG4105EFZ amidohydrolase FOC91_14010 ENOG4105KBJ sporulation protein ytfj FOC91_14015 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FOC91_14025 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FOC91_14045 ENOG4108JYZ YitT family FOC91_14085 ENOG4107YZX Universal stress protein FOC91_14105 ENOG4105VZ8 Transcriptional regulator FOC91_14115 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC91_14160 ENOG4105DC7 peptidase M24 FOC91_14195 ENOG4105SFS phosphoesterase RecJ domain protein FOC91_14205 ENOG4105VV2 FOC91_14210 ENOG4105C0B DNA polymerase III (alpha subunit) FOC91_14215 ENOG4105C6K Malic enzyme FOC91_14220 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC91_14245 ENOG4105FS0 cytoplasmic membrane protein FOC91_14250 ENOG4108REF Sporulation integral membrane protein ytvi FOC91_14260 ENOG4105BZN citrate synthase FOC91_14265 ENOG4108HMX isocitrate dehydrogenase (NADP) FOC91_14285 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC91_14290 ENOG4105BZU Histidine kinase FOC91_14295 ENOG4105C2M dna polymerase I FOC91_14310 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOC91_14315 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOC91_14340 ENOG4108TDW sporulation protein YtxC FOC91_14345 ENOG4105C22 threonyL-tRNA synthetase FOC91_14370 ENOG4105CN9 Peptidase m42 family protein FOC91_14375 ENOG4108JGH Tetr family transcriptional regulator FOC91_14380 ENOG4105CW7 secretion protein, HlyD family FOC91_14385 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC91_14430 ENOG4108RWN rrna methyltransferase FOC91_14480 ENOG4105DCG PHP domain protein FOC91_14490 ENOG4105FE9 pseudouridine synthase FOC91_14500 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FOC91_14505 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FOC91_14520 ENOG4105E0A ABC, transporter FOC91_14525 ENOG4105KFN sortase, SrtB family FOC91_14540 ENOG4105DR4 Methyltransferase FOC91_14555 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC91_14595 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC91_14600 ENOG4105J76 Periplasmic binding protein FOC91_14610 ENOG4105CEY Amp-dependent synthetase and ligase FOC91_14615 ENOG4107Z3H Transcriptional regulator, TetR family FOC91_14620 ENOG41060WC Enoyl-CoA hydratase FOC91_14625 ENOG4105BZJ Electron transfer flavoprotein FOC91_14630 ENOG4105C10 Electron transfer flavoprotein FOC91_14635 ENOG4105K63 Thioredoxin FOC91_14650 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FOC91_14660 ENOG4105E33 succinate dehydrogenase FOC91_14670 ENOG4108VXD carboxy-peptidase FOC91_14675 ENOG4105E14 MotA TolQ exbB proton channel FOC91_14680 ENOG4105ER2 Ompa motb domain protein FOC91_14685 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FOC91_14690 ENOG4108IUX (ABC) transporter FOC91_14695 ENOG4105RHA ABC transporter, permease FOC91_14700 ENOG4108Z40 Transcriptional regulator FOC91_14705 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOC91_14715 ENOG4108JCI Transcriptional regulator FOC91_14725 ENOG4105DZC cytosine deaminase FOC91_14735 ENOG4105PFC Transcriptional regulator FOC91_14750 ENOG4105KBX Transcriptional regulator, TetR family FOC91_14760 ENOG4108PCX Major Facilitator FOC91_14770 ENOG4108XJQ germination protein FOC91_14785 ENOG4105M59 Phosphodiesterase, mj0936 family FOC91_14800 ENOG4108QCI YvbH-like oligomerisation region FOC91_14830 ENOG4108IUQ atp-dependent protease FOC91_14850 ENOG4105K56 Transcriptional regulator FOC91_14875 ENOG4105D52 delta-aminolevulinic acid dehydratase FOC91_14885 ENOG41068KH stage VI sporulation protein D FOC91_14900 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC91_14920 ENOG4105DFF Rod shape-determining protein mreb FOC91_14940 ENOG4107QMS site-determining protein FOC91_14955 ENOG4105C03 ribonuclease FOC91_14965 ENOG4105X36 (ribosomal) protein FOC91_14990 ENOG4105EWM Histidine kinase FOC91_15010 ENOG4105CQC Prephenate dehydratase FOC91_15015 ENOG4108RPX mosc domain containing protein FOC91_15030 ENOG4108IYU L-aspartate oxidase FOC91_15035 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOC91_15060 ENOG41082BM Transcriptional regulator, arsr family FOC91_15065 ENOG4108IPJ Membrane FOC91_15075 ENOG4108HUF Transporter FOC91_15090 ENOG41061AI Protein of unknown function (DUF2905) FOC91_15105 ENOG4105VIE preprotein translocase, subunit YajC FOC91_15115 ENOG4108QG2 Membrane FOC91_15120 ENOG4105CKP Polysaccharide Biosynthesis Protein FOC91_15130 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC91_15135 ENOG41076HS cation diffusion facilitator family transporter FOC91_15140 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC91_15150 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC91_15175 ENOG4105CUZ uba thif-type nad fad binding protein FOC91_15180 ENOG4108VCI transcription factor, rsfa family FOC91_15185 ENOG4105D1H recombination factor protein RarA FOC91_15195 ENOG4105C3J Cysteine desulfurase FOC91_15210 ENOG4105C7H Helicase, RecD TraA family FOC91_15215 ENOG41060CR FOC91_15230 ENOG4105C02 permease FOC91_15260 ENOG4105HHA aminodeoxychorismate lyase FOC91_15270 ENOG4105XYU peptidase (U32 family) FOC91_15275 ENOG4105CFP Peptidase U32 FOC91_15290 ENOG4107XRG penicillin-binding protein FOC91_15320 ENOG4105C28 cystathionine FOC91_15325 ENOG4105C0A alcohol dehydrogenase FOC91_15335 ENOG4108V5C ABC transporter FOC91_15340 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC91_15380 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC91_15390 ENOG4105MIR Phenylalanine 4-monooxygenase FOC91_15395 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC91_15430 ENOG4108MUZ hydrolase FOC91_15440 ENOG4105G6Z alkaline phosphatase FOC91_15455 ENOG4108TVJ Nitroreductase FOC91_15475 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC91_15490 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FOC91_15495 ENOG4105CQW ribosome biogenesis GTPase YqeH FOC91_15505 ENOG410812S Rna-binding protein FOC91_15515 ENOG4108WF2 Metal Dependent Phosphohydrolase FOC91_15525 ENOG4105DXX methyltransferase FOC91_15535 ENOG4105KQC Competence protein FOC91_15540 ENOG4108UK2 deaminase FOC91_15545 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC91_15555 ENOG4105TQK DNA polymerase iii, delta' subunit FOC91_15580 ENOG4105KVH Transcriptional regulator FOC91_15585 ENOG4105CSA Coproporphyrinogen iii oxidase FOC91_15615 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOC91_15620 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC91_15630 ENOG4105KTH gatB Yqey FOC91_15635 ENOG41068P3 sporulation protein YqfC FOC91_15645 ENOG4105C9A Phoh family FOC91_15650 ENOG4105CTJ Metal Dependent Phosphohydrolase FOC91_15660 ENOG4107YR5 Diacylglycerol kinase FOC91_15665 ENOG4105KG3 cytidine deaminase FOC91_15670 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOC91_15695 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOC91_15700 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC91_15715 ENOG4105EGD dinuclear metal center protein, YbgI family FOC91_15740 ENOG41069ZM Protein of unknown function (DUF2624) FOC91_15745 ENOG4108JYZ YitT family FOC91_15750 ENOG4105FDK ABC transporter FOC91_15760 ENOG4105N80 Ferric uptake regulator, Fur family FOC91_15785 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC91_15795 ENOG4107RF6 penicillin-binding protein FOC91_15800 ENOG4105PWN phosphate abc transporter FOC91_15805 ENOG4105C8U phosphate abc transporter FOC91_15810 ENOG4105E2Z phosphate ABC transporter (Permease FOC91_15820 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOC91_15835 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOC91_15845 ENOG4105DKQ ROK family FOC91_15855 ENOG4105C5X domain protein FOC91_15875 ENOG4105C28 cystathionine FOC91_15880 ENOG4105C28 cystathionine FOC91_15890 ENOG4105C3R Methionine synthase FOC91_16010 ENOG4105C0D helicase FOC91_16040 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC91_16045 ENOG4105CJ1 ABC, transporter FOC91_16080 ENOG41080TC multidrug resistance protein FOC91_16100 ENOG4105WZW rhodanese family FOC91_16105 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FOC91_16120 ENOG4105K7K Transcriptional regulator FOC91_16135 ENOG4107YBY Hydrolase FOC91_16145 ENOG4105CBJ Metal-dependent enzyme FOC91_16160 ENOG4105DC7 peptidase M24 FOC91_16185 ENOG4105CD2 stage iii sporulation protein aa FOC91_16190 ENOG4105KR5 Stage iii sporulation protein FOC91_16195 ENOG4108CQH stage III sporulation protein AC FOC91_16200 ENOG4105KQ4 Stage iii sporulation protein ad FOC91_16210 ENOG410644B Stage III sporulation protein af FOC91_16235 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC91_16240 ENOG4108ZSR alkaline shock protein FOC91_16265 ENOG4105CTB Polyprenyl synthetase FOC91_16275 ENOG4105DX0 Hemolysin A FOC91_16285 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOC91_16290 ENOG4105S1Z Stage IV sporulation protein B FOC91_16295 ENOG4107QQR Sporulation FOC91_16310 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC91_16320 ENOG4108JUB Transcriptional regulator FOC91_16330 ENOG4107RDP Dehydrogenase FOC91_16350 ENOG4105CPP Dehydrogenase, E1 component FOC91_16355 ENOG4105C7S Dehydrogenase FOC91_16365 ENOG4105E09 nadh pyrophosphatase FOC91_16370 ENOG4105G7B Protein of unknown function (DUF2992) FOC91_16380 ENOG4108HW3 (ABC) transporter FOC91_16385 ENOG4105E5Q amino acid AbC transporter FOC91_16390 ENOG4105CDA abc transporter atp-binding protein FOC91_16395 ENOG4108QEG Membrane FOC91_16400 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FOC91_16415 ENOG4105D9U N-acetyltransferase FOC91_16420 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOC91_16430 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC91_16455 ENOG4105EJQ L-serine dehydratase FOC91_16460 ENOG4105II7 pyrroline-5-carboxylate reductase FOC91_16465 ENOG41069FQ Metallo-beta-lactamase superfamily FOC91_16470 ENOG4108IXY short-chain dehydrogenase reductase FOC91_16485 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FOC91_16525 ENOG4105CGH 5'-nucleotidase FOC91_16530 ENOG4105DFD Na H antiporter FOC91_16540 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC91_16555 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC91_16560 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC91_16585 ENOG4108R6K riboflavin synthase, subunit alpha FOC91_16590 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC91_16610 ENOG4108YM7 Gcn5-related n-acetyltransferase FOC91_16615 ENOG4105ETE Transcriptional regulator (LacI family FOC91_16625 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC91_16645 ENOG4105RHY Pfam:UPF0157 FOC91_16655 ENOG4105CPC Aldo Keto reductase FOC91_16675 ENOG4105MZ9 stage II sporulation protein m FOC91_16680 ENOG4105I3K Ferric uptake regulator, Fur family FOC91_16690 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC91_16715 ENOG4105D7N magnesium and cobalt transport protein CorA FOC91_16745 ENOG4105DVE abc transporter atp-binding protein FOC91_16750 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC91_16755 ENOG4105DZ1 carboxypeptidase FOC91_16760 ENOG41082AN stage II sporulation protein FOC91_16770 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC91_16775 ENOG4105C8J )-transporter FOC91_16795 ENOG41090VF Stage v sporulation protein ac FOC91_16800 ENOG4105CZ3 stage V sporulation protein ad FOC91_16810 ENOG4105G6R Stage v sporulation protein ae FOC91_16820 ENOG4105J7I hydrolase FOC91_16825 ENOG4105PTM secreted protein FOC91_16830 ENOG4107ZE5 PPIases accelerate the folding of proteins FOC91_16865 ENOG4105CE4 GlcNAc 6-P deacetylase FOC91_16885 ENOG4105CID antiterminator FOC91_16900 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOC91_16920 ENOG4105BZU Histidine kinase FOC91_16925 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC91_16965 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOC91_16985 ENOG4105DTD Dehydrogenase FOC91_16990 ENOG4105K7K Transcriptional regulator FOC91_17020 ENOG4105CHU acetyl-coa acetyltransferase FOC91_17070 ENOG4105CG3 alpha amylase, catalytic region FOC91_17080 ENOG4107FKK extracellular solute-binding protein family 1 FOC91_17090 ENOG4105EG2 ABC transporter, permease FOC91_17095 ENOG4105FKQ transcriptional regulator FOC91_17100 ENOG4105CHM Aminotransferase FOC91_17110 ENOG4108HGU Histidine kinase FOC91_17165 ENOG4105UIN FOC91_17175 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FOC91_17190 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FOC91_17195 ENOG4105EPM Diguanylate phosphodiesterase FOC91_17210 ENOG4107IN1 Protein of unknown function (DUF1797) FOC91_17220 ENOG4108XRC Protein of unknown function (DUF458) FOC91_17255 ENOG4107ZYR domain protein FOC91_17260 ENOG4105CN5 Metallo-Beta-Lactamase FOC91_17270 ENOG4108X4Q Hydrolase FOC91_17275 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC91_17290 ENOG4105CPP Dehydrogenase, E1 component FOC91_17340 ENOG4105CXN decarboxylase FOC91_17360 ENOG4105ECY inositol monophosphatase FOC91_17370 ENOG4105CI3 gtp-binding protein typa FOC91_17375 ENOG4105QA2 FOC91_17395 ENOG4108IAB Phoh family FOC91_17410 ENOG4105CNI cell division protein FtsW FOC91_17415 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FOC91_17465 ENOG4106UY4 Inherit from COG: Scp-like extracellular FOC91_17480 ENOG4107TB6 phosphoglycerate mutase FOC91_17500 ENOG4106H78 methyltransferase FOC91_17510 ENOG4105H20 Sporulation integral membrane protein YlbJ FOC91_17515 ENOG4105D78 K07001 NTE family protein FOC91_17520 ENOG41063PX domain protein FOC91_17530 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) FOC91_17560 ENOG4108IMY Transcriptional regulator FOC91_17705 ENOG4105CAR Terminase, large subunit FOC91_17715 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOC91_17790 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC91_17800 ENOG41086D8 Transcriptional regulator FOC91_17830 ENOG4105KNH Nucleic acid-binding protein FOC91_17865 ENOG41068DC Essential cell division protein (By similarity) FOC91_17870 ENOG4105CJN penicillin-binding protein FOC91_17875 ENOG4105CJN penicillin-binding protein FOC91_17880 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC91_17895 ENOG4105CNI cell division protein FtsW FOC91_17905 ENOG4105D4A Cell wall formation (By similarity) FOC91_17910 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FOC91_17915 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOC91_17920 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOC91_17930 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC91_17940 ENOG4105WR5 sporulation protein, YlmC YmxH family FOC91_17945 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOC91_17950 ENOG4105DFA alanine racemase domain protein FOC91_17960 ENOG41067XK integral membrane protein FOC91_17965 ENOG4105DBK s4 domain protein FOC91_17990 ENOG4105C34 Pseudouridine synthase FOC91_18070 ENOG4105DC7 peptidase M24 FOC91_18085 ENOG4105DSJ YicC domain protein FOC91_18105 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOC91_18110 ENOG4105C25 Primosomal protein n' FOC91_18115 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC91_18125 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOC91_18135 ENOG4108ZF3 Phosphatase FOC91_18140 ENOG4105D9P serine threonine protein kinase FOC91_18145 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC91_18150 ENOG4105DJV ribulose-phosphate 3-epimerase FOC91_18155 ENOG4105FJ0 thiamine FOC91_18170 ENOG4108ZAA Alkaline-shock protein FOC91_18175 ENOG4105DP4 dak2 domain fusion protein ylov FOC91_18180 ENOG4105CB5 ATP-dependent DNA helicase recG FOC91_18195 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC91_18200 ENOG4105CHR reductase FOC91_18215 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOC91_18220 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOC91_18240 ENOG4105VB6 UPF0109 protein FOC91_18265 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FOC91_18280 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOC91_18285 ENOG4105C79 DNA protecting protein DprA FOC91_18290 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOC91_18300 ENOG4108HE4 integrase family FOC91_18345 ENOG4105KNE Phosphatidate cytidylyltransferase FOC91_18355 ENOG4105DZP Membrane-associated zinc metalloprotease FOC91_18370 ENOG4105EKQ RNA-directed DNA polymerase FOC91_18375 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC91_18385 ENOG4105CHV Transcription elongation factor NusA FOC91_18390 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FOC91_18395 ENOG4105VHM ribosomal protein FOC91_18405 ENOG4105W7A Protein of unknown function (DUF503) FOC91_18420 ENOG4105DTN riboflavin biosynthesis protein ribF FOC91_18440 ENOG4105C1V Peptidase, M16 FOC91_18450 ENOG4105E35 Dipicolinate synthase subunit A FOC91_18455 ENOG4108S0H Dipicolinic acid synthetase, b subunit FOC91_18460 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC91_18470 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC91_18480 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FOC91_18490 ENOG4107QZI cell division protein FtsK FOC91_18495 ENOG4105FDP GntR family transcriptional regulator FOC91_18500 ENOG4105DIH basic membrane FOC91_18505 ENOG4108JQ9 ABC transporter FOC91_18510 ENOG4105UIB (ABC) transporter FOC91_18530 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FOC91_18535 ENOG4105XZV Protein of unknown function (DUF3243) FOC91_18550 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOC91_18575 ENOG4105D48 metallophosphoesterase FOC91_18580 ENOG4105MCT stage V sporulation protein S FOC91_18585 ENOG4108IGT Dipeptidase FOC91_18590 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FOC91_18595 ENOG4105DQU oxidoreductase, subunit beta FOC91_18625 ENOG4107QHE Choloylglycine hydrolase FOC91_18635 ENOG410890F Dynamin family FOC91_18640 ENOG4105E0M Sulfatase FOC91_18650 ENOG4105F0V Cell wall hydrolase FOC91_18740 ENOG4105BZU Histidine kinase FOC91_18745 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC91_18775 ENOG4105D03 DNA-3-methyladenine glycosylase II FOC91_18780 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC91_18790 ENOG4105CGK Exodeoxyribonuclease III FOC91_18810 ENOG4105E0A ABC, transporter FOC91_18815 ENOG4105NIV Esterase FOC91_18835 ENOG4105VPX protein, conserved in bacteria FOC91_18840 ENOG410681U heavy metal transport detoxification protein FOC91_18845 ENOG4105C59 p-type ATPase FOC91_18850 ENOG4105K70 DNA-binding protein FOC91_18855 ENOG4105TMB Formate nitrite transporter FOC91_18875 ENOG4105C85 amino acid FOC91_18885 ENOG4108SJC Membrane FOC91_18890 ENOG4107QW4 alcohol dehydrogenase FOC91_18895 ENOG4105E98 transcriptional regulator DeoR family FOC91_18900 ENOG4105DE4 1-phosphofructokinase FOC91_18905 ENOG4105DM4 PTS System FOC91_18910 ENOG41069ER domain protein FOC91_18940 ENOG4106F1P AAA ATPase, central domain protein FOC91_18945 ENOG4105EN6 Membrane FOC91_18950 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC91_18955 ENOG4105CXI aluminum resistance protein FOC91_18960 ENOG4105KV4 Transcriptional regulator FOC91_18965 ENOG4105C5F glutamine synthetase FOC91_18975 ENOG4105K7K Transcriptional regulator FOC91_18995 ENOG4108SVB resolvase FOC91_19005 ENOG4105CGH 5'-nucleotidase FOC91_19045 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC91_19115 ENOG4105T6C Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps FOC91_19135 ENOG4105BZ1 (ABC) transporter FOC91_19140 ENOG4105BZ1 (ABC) transporter FOC91_19155 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC91_19180 ENOG41067MG lrgb family FOC91_19190 ENOG4107RSM transcriptional regulator FOC91_19200 ENOG4105CJ1 ABC, transporter FOC91_19220 ENOG4107QIV Cytochrome c biogenesis protein FOC91_19235 ENOG4105EKQ RNA-directed DNA polymerase FOC91_19275 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) FOC91_19300 ENOG4108903 Formimidoylglutamase FOC91_19305 ENOG4108VJ1 Transcriptional regulator (CarD family FOC91_19310 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC91_19315 ENOG4105CBC glutamate synthase FOC91_19320 ENOG4105CK7 Sodium proline symporter FOC91_19325 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FOC91_19330 ENOG4105FBA Phospholipase Carboxylesterase FOC91_19335 ENOG4105BZU Histidine kinase FOC91_19345 ENOG4107AYK membrAne FOC91_19395 ENOG4108IMY Transcriptional regulator FOC91_19405 ENOG4105CEY Amp-dependent synthetase and ligase FOC91_19410 ENOG4107ZYJ bioY protein FOC91_19415 ENOG4107F3J Amp-dependent synthetase and ligase FOC91_19435 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC91_19475 ENOG4108I0Z Aconitate hydratase FOC91_19480 ENOG4108JJA ABC, transporter FOC91_19490 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC91_19495 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC91_19525 ENOG4105W8X HesB YadR YfhF-family protein FOC91_19535 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOC91_19540 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) FOC91_19545 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC91_19550 ENOG4105C0H protease FOC91_19555 ENOG4105K4P CoA-binding domain protein FOC91_19560 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC91_19570 ENOG4105D9R oxidoreductase FOC91_19580 ENOG4105CIG ABC transporter FOC91_19600 ENOG4105EMN RNA polymerase sigma factor FOC91_19610 ENOG4108KGH TRANSCRIPTIONal FOC91_19615 ENOG4107QJT sodium dicarboxylate symporter FOC91_19680 ENOG4105E1K spore germination protein FOC91_19685 ENOG4108JB9 formate dehydrogenase FOC91_19695 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FOC91_19700 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC91_19710 ENOG4105TMB Formate nitrite transporter FOC91_19715 ENOG4105D06 uba thif-type nad fad binding protein FOC91_19720 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC91_19725 ENOG4108ZAF Molybdopterin FOC91_19735 ENOG4105D1F ATP-binding protein FOC91_19750 ENOG410696E Membrane FOC91_19755 ENOG4105FR1 rard protein FOC91_19765 ENOG4105EWU Squalene--hopene cyclase FOC91_19775 ENOG4105CHR reductase FOC91_19780 ENOG4105C26 Dehydrogenase FOC91_19790 ENOG4108IA2 Sodium pantothenate symporter FOC91_19805 ENOG4106IQC argininosuccinate lyase FOC91_19815 ENOG410904N short-chain dehydrogenase reductase FOC91_19855 ENOG4105VEQ Cold shock protein FOC91_19870 ENOG4108R1P FOC91_19880 ENOG41073R8 VanW family FOC91_19885 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC91_19900 ENOG4105KT7 mgtC SapB transporter FOC91_19910 ENOG4105E39 Enoyl-CoA hydratase FOC91_19915 ENOG4105K64 Glycosyl transferase, family 2 FOC91_19925 ENOG4108UT6 Transferase hexapeptide repeat containing protein FOC91_19950 ENOG4105CQB FAD linked oxidase domain protein FOC91_19955 ENOG4105C09 Bile acid FOC91_19990 ENOG4105CIS alcohol dehydrogenase FOC91_19995 ENOG41082BM Transcriptional regulator, arsr family FOC91_20020 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC91_20050 ENOG4108A04 Beta-lactamase FOC91_20055 ENOG4105DPN Oligoendopeptidase f FOC91_20060 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FOC91_20065 ENOG4105E5K Alpha-amylase FOC91_20080 ENOG4105C98 muts2 protein FOC91_20100 ENOG4107V2S Transcriptional regulator FOC91_20120 ENOG4107ZY0 Phenazine biosynthesis-like protein FOC91_20125 ENOG4105NX3 Membrane FOC91_20130 ENOG4105DQ5 transport system permease protein FOC91_20135 ENOG4105EHG Permease protein FOC91_20140 ENOG4108MES Periplasmic binding protein FOC91_20155 ENOG4107R3E Citrate transporter FOC91_20165 ENOG4108TN2 lmbE family FOC91_20195 ENOG4105CIS alcohol dehydrogenase FOC91_20235 ENOG4105H3G oxidoreductase FOC91_20270 ENOG4107YXZ hydrolase, family 25 FOC91_20285 ENOG4105D7V transposase FOC91_20290 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FOC91_20365 ENOG4105KVH Transcriptional regulator FOC91_20370 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FOC91_20390 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC91_20425 ENOG4105D9R oxidoreductase FOC91_20430 ENOG4108TZY GntR Family Transcriptional Regulator FOC91_20465 ENOG4105C44 Serine transporter FOC91_20500 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC91_20505 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC91_20520 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC91_20525 ENOG4105C6Z Gluconate FOC91_20530 ENOG4105CMG Carbohydrate kinase FOC91_20535 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOC91_20540 ENOG4105XDF Protein of unknown function (DUF1272) FOC91_20545 ENOG4105DDN Pentapeptide repeat-containing protein FOC91_20560 ENOG4105C37 (CBS) domain FOC91_20590 ENOG4105EV4 Multidrug resistance protein mdtH FOC91_20600 ENOG4105DMQ Methyltransferase FOC91_20640 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC91_20650 ENOG4108UW5 maltose o-acetyltransferase FOC91_20655 ENOG4105DKQ ROK family FOC91_20660 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FOC91_20700 ENOG4105D7V transposase FOC91_20750 ENOG4105CJ1 ABC, transporter FOC91_20760 ENOG4108PSK reductase FOC91_20780 ENOG4105CA9 Pyruvate kinase FOC91_20790 ENOG4108RCM Nitroreductase FOC91_20795 ENOG4105KVH Transcriptional regulator FOC91_20815 ENOG4105WH1 Two component transcriptional regulator luxr family FOC91_20825 ENOG4108Z66 YbaK ebsC protein FOC91_20830 ENOG4108K8S endonuclease I FOC91_20855 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC91_20890 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC91_20900 ENOG4105CRW Short chain fatty acid transporter FOC91_20910 ENOG4107AUC FOC91_20915 ENOG4105KBX Transcriptional regulator, TetR family FOC91_20920 ENOG4105KPY Small multidrug resistance protein FOC91_20925 ENOG4105RXJ FOC91_20935 ENOG41069JR FOC91_20940 ENOG4105DA5 (ABC) transporter FOC91_20955 ENOG4105CZM Major Facilitator FOC91_20960 ENOG4107MII Sugar-specific transcriptional regulator TrmB FOC91_20970 ENOG4108ISG Major Facilitator FOC91_21015 ENOG4108IG5 Transcriptional regulator FOC91_21025 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC91_21040 ENOG4108IBT Inherit from COG: transposase FOC91_21055 ENOG410874W AraC family transcriptional regulator FOC91_21060 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC91_21075 ENOG4108AEY RNA polymerase sigma factor FOC91_21095 ENOG4108JQ1 Dehydrogenase FOC91_21110 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC91_21130 ENOG4106P55 Transcriptional regulator FOC91_21140 ENOG4107QR9 Iron-sulfur cluster binding protein FOC91_21145 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) FOC91_21150 ENOG4105DJB Major Facilitator Superfamily FOC91_21155 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC91_21165 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 FOC91_21170 ENOG4108U05 Transcriptional regulator FOC91_21185 ENOG4105BZU Histidine kinase FOC91_21200 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FOC91_21220 ENOG4105JQZ Methyltransferase FOC91_21225 ENOG4105W1Y Transcriptional regulator FOC91_21235 ENOG4105C88 aminopeptidase FOC91_21250 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC91_21260 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FOC91_21265 ENOG4108NNI Beta-lactamase domain-containing protein FOC91_21290 ENOG4105K6H D-cysteine desulfhydrase FOC91_21315 ENOG41062D9 Histidine kinase FOC91_21320 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC91_21335 ENOG4105IIP Membrane FOC91_21345 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC91_21350 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOC91_21405 ENOG4105F7F Chaperone FOC91_21420 ENOG41085FC arsR family transcriptional regulator FOC91_21425 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC91_21430 ENOG4105D6J arsenicaL-resistance protein FOC91_21460 ENOG4105DIK (ABC) transporter FOC91_21465 ENOG4105CC5 ABC transporter FOC91_21470 ENOG4105DSE periplasmic solute binding protein FOC91_21475 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FOC91_21480 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC91_21490 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC91_21505 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FOC91_21510 ENOG4108TWJ NADH dehydrogenase subunit 5 FOC91_21540 ENOG4108606 TspO/MBR family FOC91_21560 ENOG4105YA8 Transcriptional regulator FOC91_21565 ENOG4106A3M Cytochrome p-450 FOC91_21610 ENOG41061CK Antibiotic biosynthesis monooxygenase FOC91_21615 ENOG4105CGH 5'-nucleotidase FOC91_21630 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC91_21645 ENOG4105E2A Dehydrogenase FOC91_21710 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOC91_21735 ENOG4105DWD nucleoside recognition domain protein FOC91_21750 ENOG4105FDT acyl-CoA dehydrogenase FOC91_21760 ENOG4108ZHR arsR family transcriptional regulator FOC91_21765 ENOG4108ZRV stage ii sporulation protein p FOC91_21770 ENOG4106N3A copper homeostasis protein cutc FOC91_21780 ENOG4107258 Transcriptional regulator FOC91_21785 ENOG4105P4J Allophanate hydrolase, subunit 1 FOC91_21820 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FOC91_21825 ENOG4107RF6 penicillin-binding protein FOC91_21855 ENOG4105F1N DNA alkylation repair FOC91_21865 ENOG4108IQI permease FOC91_21875 ENOG410635A Membrane FOC91_21960 ENOG4108XET gCN5-related N-acetyltransferase FOC91_21990 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FOC91_22005 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC91_22040 ENOG4105FS7 Transcriptional regulator FOC91_22045 ENOG4108TVJ Nitroreductase FOC91_22085 ENOG4105CH6 catalase FOC91_22090 ENOG4105C8Y Acetylornithine aminotransferase FOC91_22100 ENOG4105CKK Glycosyl transferase, family 2 FOC91_22125 ENOG4105CSH Transporter FOC91_22140 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC91_22165 ENOG41068WN FOC91_22190 ENOG4108WCX response regulator FOC91_22200 ENOG41090T1 Membrane FOC91_22215 ENOG4105VMP Transcriptional regulator FOC91_22225 ENOG4105G6Z alkaline phosphatase FOC91_22230 ENOG4105ECK Fatty Acid Desaturase FOC91_22235 ENOG4105E0Y RtcB Protein FOC91_22245 ENOG4107258 Transcriptional regulator FOC91_22255 ENOG4105II7 pyrroline-5-carboxylate reductase FOC91_22260 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FOC91_22290 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FOC91_22315 ENOG41061GT Aldolase FOC91_22325 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) FOC91_22330 ENOG4105DKT Transcriptional regulator FOC91_22340 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FOC91_22350 ENOG4105D4B ABC, transporter FOC91_22365 ENOG4108JUB Transcriptional regulator FOC91_22370 ENOG4105J5T Amp-dependent synthetase and ligase FOC91_22375 ENOG4105E39 Enoyl-CoA hydratase FOC91_22380 ENOG4105CY2 Citrate transporter FOC91_22390 ENOG41069ER domain protein FOC91_22405 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) FOC91_22425 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC91_22435 ENOG4105CIH Imidazole acetol-phosphate transaminase FOC91_22455 ENOG41082JN Transcriptional regulator FOC91_22460 ENOG4105EYF MMPL domain protein FOC91_22470 ENOG4105C5H ABC transporter FOC91_22475 ENOG4105E0M Sulfatase FOC91_22480 ENOG4108ZCF integral membrane protein FOC91_22550 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FOC91_22570 ENOG4105E09 nadh pyrophosphatase FOC91_22585 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FOC91_22590 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC91_22595 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOC91_22605 ENOG4105C02 permease FOC91_22650 ENOG4105DVE abc transporter atp-binding protein FOC91_22665 ENOG4108ZMI UPF0477 protein FOC91_22680 ENOG4105CHM Aminotransferase FOC91_22710 ENOG41089UC methyltransferase, type 11 FOC91_22725 ENOG4107BMA Transglycosylase associated protein FOC91_22745 ENOG4106K7D Major facilitator family transporter FOC91_22750 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC91_22805 ENOG4105EPR degv family FOC91_22815 ENOG4105DVH amino acid FOC91_22820 ENOG4105DPN Oligoendopeptidase f FOC91_22850 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC91_22855 ENOG4105BZU Histidine kinase FOC91_22860 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FOC91_22905 ENOG4105DTQ mandelate racemase muconate lactonizing FOC91_22920 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOC91_22925 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC91_22940 ENOG4107T5V SNARE associated Golgi FOC91_22970 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FOC91_22980 ENOG41080HI glycine oxidase FOC91_22985 ENOG4105CTU Proline racemase FOC91_22990 ENOG4105CTU Proline racemase FOC91_22995 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC91_23000 ENOG4105C26 Dehydrogenase FOC91_23005 ENOG4105BZG amino acid carrier protein FOC91_23025 ENOG4108M1A Chitin-binding protein FOC91_23075 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC91_23095 ENOG4105EEM helicase FOC91_23115 ENOG4108Z7F N-acetyltransferase FOC91_23145 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC91_23150 ENOG4107YB6 acetyltransferase, (GNAT) family FOC91_23155 ENOG4105MSB protein, conserved in bacteria FOC91_23160 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC91_23175 ENOG4108M1A Chitin-binding protein FOC91_23180 ENOG41082BV acetyltransferase FOC91_23210 ENOG4108IJ7 Glycine betaine FOC91_23215 ENOG4107SQ8 Glycine betaine FOC91_23240 ENOG4108TIT dATP pyrophosphohydrolase FOC91_23250 ENOG4105DBI uridine monophosphokinase FOC91_23255 ENOG4105RHY Pfam:UPF0157 FOC91_23260 ENOG4105E1F short-chain dehydrogenase reductase FOC91_23270 ENOG4107RUY (E1 component), alpha subunit FOC91_23280 ENOG4107QKR Dehydrogenase FOC91_23300 ENOG41062ES Transcriptional regulator FOC91_23320 ENOG4105E98 transcriptional regulator DeoR family FOC91_23325 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC91_23340 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOC91_23375 ENOG4107Z3H Transcriptional regulator, TetR family FOC91_23410 ENOG4105MSI germination protein ypeb FOC91_23465 ENOG4105FDR Membrane FOC91_23475 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC91_23480 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FOC91_23505 ENOG4108IUM Glycogen debranching enzyme FOC91_23525 ENOG4105PAD Hydrolase FOC91_23550 ENOG4107VFR oxidoreductase FOC91_23585 ENOG4105PKS Excinuclease abc c subunit domain protein FOC91_23620 ENOG4105KWG Pfam:DUF1696 FOC91_23625 ENOG4108NRW Phospholipase, patatin family FOC91_23645 ENOG4108XI2 Domain of unknown function (DUF1963) FOC91_23655 ENOG4107TB6 phosphoglycerate mutase FOC91_23680 ENOG4108Z4K mutator MutT protein FOC91_23685 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC91_23690 ENOG4105E09 nadh pyrophosphatase FOC91_23695 ENOG4105FCD Major Facilitator FOC91_23730 ENOG4107Y9U Membrane FOC91_23755 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC91_23770 ENOG4107Y80 Major Facilitator superfamily FOC91_23790 ENOG4108V4B ThiJ pfpI FOC91_23825 ENOG4105FQP Beta-lactamase FOC91_23835 ENOG4105CHR reductase FOC91_23840 ENOG4108IG5 Transcriptional regulator FOC91_23845 ENOG4105CJN penicillin-binding protein FOC91_23850 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOC91_23855 ENOG4105CB2 alcohol dehydrogenase FOC91_23860 ENOG4105RHY Pfam:UPF0157 FOC91_23870 ENOG4108HGU Histidine kinase FOC91_23905 ENOG4107RF6 penicillin-binding protein FOC91_23910 ENOG4105BZU Histidine kinase FOC91_23915 ENOG410667J hydrolase FOC91_24025 ENOG4105ETU transcriptional activator (TenA FOC91_24110 ENOG4105DK7 lysyl-tRNA synthetase FOC91_24120 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FOC91_24140 ENOG4105CPQ Dehydrogenase FOC91_24180 ENOG4105CUV Homoserine Kinase FOC91_24200 ENOG4107Y80 Major Facilitator superfamily FOC91_24225 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC91_24225 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC91_24265 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC91_24275 ENOG4105T9C HD domain FOC91_24305 ENOG4105DBI uridine monophosphokinase FOC91_24310 ENOG4105WCN acetyltransferase FOC91_24320 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC91_24325 ENOG4107QX3 carboxylase FOC91_24330 ENOG4105E39 Enoyl-CoA hydratase FOC91_24335 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC91_24340 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FOC91_24345 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC91_24350 ENOG4105C1G acyl-Coa dehydrogenase FOC91_24375 ENOG4105D7V transposase FOC91_24380 ENOG4107RGJ metallophosphoesterase FOC91_24390 ENOG4107RF6 penicillin-binding protein FOC91_24395 ENOG4107RF6 penicillin-binding protein FOC91_24405 ENOG4105EMN RNA polymerase sigma factor FOC91_24420 ENOG4105CIN aminoacyl-histidine dipeptidase FOC91_24455 ENOG41090HR transcriptional regulator FOC91_24555 ENOG41088CC tellurite resistance protein tehB FOC91_24575 ENOG4108RZE Tetr family transcriptional regulator FOC91_24590 ENOG4105C1J atp-dependent rna helicase FOC91_24605 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC91_24640 ENOG4107STF Involved in phosphonate degradation (By similarity) FOC91_24650 ENOG4105RD7 BadF BadG BcrA BcrD FOC91_24675 ENOG4105F32 YngK protein FOC91_24700 ENOG4108KPJ rna polymerase sigma factor FOC91_24705 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B FOC91_24715 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC91_24745 ENOG4108JCI Transcriptional regulator FOC91_24765 ENOG4105BZ1 (ABC) transporter FOC91_24770 ENOG4105BZ1 (ABC) transporter FOC91_24785 ENOG4108RPX mosc domain containing protein FOC91_24790 ENOG4105DND Transcriptional regulator FOC91_24805 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC91_24810 ENOG4107V2S Transcriptional regulator FOC91_25035 ENOG4107QPV Serine Threonine protein kinase FOC91_25050 ENOG4105KRN Transcriptional regulator, abrb family FOC91_25125 ENOG4105C2M dna polymerase I FOC91_25130 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC91_25245 ENOG4105VEQ Cold shock protein FOC91_25255 ENOG41068WN FOC91_25260 ENOG41089UC methyltransferase, type 11 FOC91_25270 ENOG4105C1Q protoporphyrinogen oxidase FOC91_25300 ENOG4105WCN acetyltransferase FOC91_25325 ENOG4105EYF MMPL domain protein FOC91_25335 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC91_25350 ENOG41081I9 integral membrane protein FOC91_25380 ENOG4108D32 Methyltransferase FOC91_25410 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC91_25420 ENOG4105C19 ABC transporter FOC91_25430 ENOG4105C22 threonyL-tRNA synthetase FOC91_25435 ENOG4105FE9 pseudouridine synthase FOC91_25455 ENOG4105BZG amino acid carrier protein FOC91_25475 ENOG4105K70 DNA-binding protein FOC91_25490 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC91_25495 ENOG4105WQT MbtH domain protein FOC91_25500 ENOG4105CEY Amp-dependent synthetase and ligase FOC91_25505 ENOG4105WQI isochorismatase FOC91_25510 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FOC91_25515 ENOG4105E4F Isochorismate synthase FOC91_25520 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FOC91_25525 ENOG4105FCD Major Facilitator FOC91_25550 ENOG4107RFY SbcCD D subunit FOC91_25565 ENOG4105E39 Enoyl-CoA hydratase FOC91_25570 ENOG4105N14 lysine exporter protein LysE YggA FOC91_25580 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC91_25585 ENOG4105C1G acyl-Coa dehydrogenase FOC91_25590 ENOG4105CR4 methylisocitrate lyase FOC91_25595 ENOG4105DXD 2-methylcitrate dehydratase FOC91_25605 ENOG4105W8X HesB YadR YfhF-family protein FOC91_25610 ENOG4105CZM Major Facilitator FOC91_25620 ENOG4105BZ4 penicillin-binding protein FOC91_25670 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC91_25730 ENOG4105SZ6 Thioredoxin FOC91_25740 ENOG410841Q phosphoesterase PA-phosphatase related protein FOC91_25745 ENOG4108N23 SpoOM-related protein FOC91_25785 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FOC91_25790 ENOG4108JUB Transcriptional regulator FOC91_25795 ENOG4108TSC N-acetyltransferase FOC91_25800 ENOG4107S4Y M20 DapE family protein YgeY FOC91_25815 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC91_25840 ENOG4105C37 (CBS) domain FOC91_25875 ENOG4105E90 ABC transporter FOC91_25880 ENOG4108IJ8 ABC transporter FOC91_25910 ENOG4105CMG Carbohydrate kinase FOC91_25915 ENOG4105CMG Carbohydrate kinase FOC91_25950 ENOG4105WH1 Two component transcriptional regulator luxr family FOC91_25955 ENOG4105BZU Histidine kinase FOC91_25960 ENOG4105D8X mechanosensitive ion channel FOC91_25995 ENOG4105F0I Aminotransferase FOC91_26000 ENOG4108MES Periplasmic binding protein FOC91_26020 ENOG4105CAQ asparagine synthetase FOC91_26025 ENOG4107Y70 Heat shock protein FOC91_26030 ENOG4108KF3 Electron transport protein SCO1 SenC FOC91_26035 ENOG4105E8R UPF0173 metal-dependent hydrolase FOC91_26040 ENOG4108RCR degv family FOC91_26050 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOC91_26060 ENOG4108UT2 hemolysin iii FOC91_26065 ENOG4105E9Q Acyl-transferase FOC91_26075 ENOG4107RVG penicillin-binding protein FOC91_26095 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FOC91_26115 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FOC91_26140 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FOC91_26145 ENOG4105KD7 acetyltransferase FOC91_26160 ENOG4105C0A alcohol dehydrogenase FOC91_26165 ENOG4105CY2 Citrate transporter FOC91_26170 ENOG4107XGZ Hydrolase FOC91_26190 ENOG4105C8J )-transporter FOC91_26205 ENOG41062D9 Histidine kinase FOC91_26210 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC91_26215 ENOG4107QPK )-transporter FOC91_26220 ENOG4105BZW Glycerate kinase FOC91_26340 ENOG4107EV6 Inherit from COG: YD repeat protein FOC91_26365 ENOG4105EC2 ftsk spoIIIe FOC91_26385 ENOG4105C5S asparaginyl-tRNA synthetase FOC91_26430 ENOG4107YX5 Pfam:DUF548 FOC91_26460 ENOG4108UUM single-stranded DNA-binding protein FOC91_26475 ENOG4105C5H ABC transporter FOC91_26540 ENOG4105MCT stage V sporulation protein S FOC91_26575 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FOC91_26580 ENOG4108IFG nitrite reductase, (NAD(P)H) FOC91_26585 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOC91_26590 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC91_26595 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC91_26600 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC91_26620 ENOG4108ZAF Molybdopterin FOC91_26625 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC91_26630 ENOG4105D06 uba thif-type nad fad binding protein FOC91_26635 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC91_26640 ENOG4107V6Q Cyclic nucleotide-binding domain FOC91_26650 ENOG4105R3A Nitrate reductase FOC91_26655 ENOG4108IUE nitrate reductase beta subunit FOC91_26675 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC91_26690 ENOG4108V06 Glutathione peroxidase FOC91_26700 ENOG4105CNW domain protein FOC91_26715 ENOG4105EMN RNA polymerase sigma factor FOC91_26720 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FOC91_26730 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FOC91_26755 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC91_26780 ENOG4105KBJ sporulation protein ytfj FOC91_26855 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC91_26885 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC91_26890 ENOG4108JYZ YitT family FOC91_26895 ENOG41087PP glycosyltransferase MGT family FOC91_26915 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC91_26925 ENOG4108X4Q Hydrolase FOC91_26935 ENOG41069HH 4-oxalocrotonate tautomerase FOC91_26955 ENOG4105IKQ hydratase FOC91_26965 ENOG4105KME endoribonuclease L-psp FOC91_26980 ENOG4105U1N riboflavin FOC91_26990 ENOG4105EFA 4-hydroxyphenylacetate FOC91_27010 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC91_27020 ENOG4108VXD carboxy-peptidase FOC91_27030 ENOG4108ZRV stage ii sporulation protein p FOC91_27050 ENOG4108Z7R Chaperone CsaA FOC91_27070 ENOG4105C37 (CBS) domain FOC91_27075 ENOG4105SXS Protein of unknown function (DUF456) FOC91_27095 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC91_27105 ENOG4108S4H thioesterase Superfamily protein FOC91_27115 ENOG4108PJD permease FOC91_27130 ENOG4107T5V SNARE associated Golgi FOC91_27150 ENOG4105CVJ phosphoglycerate mutase FOC91_27175 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC91_27185 ENOG4105K4T epimerase FOC91_27195 ENOG4105DSE periplasmic solute binding protein FOC91_27200 ENOG4108IBT Inherit from COG: transposase FOC91_27220 ENOG4105CKI cobalamin synthesis protein FOC91_27225 ENOG4107QM2 Aldo Keto reductase FOC91_27245 ENOG4105DEN Luciferase family FOC91_27260 ENOG4108WPJ Ferritin-like domain FOC91_27265 ENOG4108K88 Membrane FOC91_27280 ENOG4105C8Q Methyl-accepting chemotaxis FOC91_27305 ENOG4107XZQ multidrug resistance protein FOC91_27310 ENOG4107SET aldo keto reductase FOC91_27315 ENOG4105YVS arsR family transcriptional regulator FOC91_27325 ENOG4105KRN Transcriptional regulator, abrb family FOC91_27375 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC91_27380 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FOC91_27390 ENOG4105YWU small acid-soluble spore protein FOC91_27395 ENOG4108WBH protein TIM barrel FOC91_27410 ENOG4105CEY Amp-dependent synthetase and ligase FOC91_27415 ENOG4105DUU IucA IucC family protein FOC91_27425 ENOG4105VRR gCN5-related N-acetyltransferase FOC91_27430 ENOG4105KT7 mgtC SapB transporter FOC91_27445 ENOG4105BZU Histidine kinase FOC91_27450 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC91_27460 ENOG4108KGH TRANSCRIPTIONal FOC91_27485 ENOG4105D6E homoserine dehydrogenase FOC91_27510 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FOC91_27530 ENOG4105BZU Histidine kinase FOC91_27535 ENOG4105EFI regulatoR FOC91_27540 ENOG4105BZ1 (ABC) transporter FOC91_27585 ENOG4108JJ8 (ABC) transporter FOC91_27590 ENOG4108JJ9 ABC, transporter FOC91_27595 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC91_27600 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC91_27630 ENOG4105EGI Transcriptional regulator FOC91_27640 ENOG4105C32 Amino acid ABC transporter (Permease) FOC91_27645 ENOG4108IV0 ABC, transporter FOC91_27650 ENOG4105C0Z ABC transporter FOC91_27660 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC91_27665 ENOG4108Z7G MaoC domain protein dehydratase FOC91_27685 ENOG4105CKI cobalamin synthesis protein FOC91_27700 ENOG4106F5Q Membrane FOC91_27705 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC91_27710 ENOG4108TVJ Nitroreductase FOC91_27715 ENOG4107ZXU DSBA oxidoreductase FOC91_27720 ENOG4108Z40 Transcriptional regulator FOC91_27725 ENOG4105GZI Transcriptional regulator FOC91_27730 ENOG4107RT3 EamA-like transporter family FOC91_27740 ENOG4105KTB nuclear export factor GLE1 FOC91_27745 ENOG4108T5E Copper resistance protein FOC91_27815 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC91_27820 ENOG4105DY8 decarboxylase FOC91_27885 ENOG4107R16 Multicopper oxidase FOC91_27890 ENOG4107RAQ aminopeptidase FOC91_27920 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FOC91_27925 ENOG4105D9N nucleoside FOC91_27935 ENOG4107RHR regulatoR FOC91_27945 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC91_27990 ENOG4105C0X amino acid FOC91_27995 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOC91_28010 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOC91_28035 ENOG41068WN FOC91_28080 ENOG4108IBT Inherit from COG: transposase FOC91_28100 ENOG4105CYC Transferase FOC91_28105 ENOG4105DY9 regulatoR FOC91_28125 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FOC91_28130 ENOG4105C6X Major Facilitator FOC91_28155 ENOG4105C7B Threonine dehydratase FOC91_28165 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC91_28175 ENOG4105C7K acetolactate synthase FOC91_28180 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC91_28185 ENOG4105CHR reductase FOC91_28190 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC91_28205 ENOG4106KE4 Dehydrogenase FOC91_28220 ENOG4105H67 Protein of unknown function (DUF421) FOC91_28225 ENOG4105X5K response regulator receiver protein FOC91_28235 ENOG4105C8J )-transporter FOC91_28255 ENOG4105C6T cysteine synthase FOC91_28260 ENOG4105EU0 Major facilitator Superfamily FOC91_28270 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC91_28285 ENOG4105DXI Major Facilitator superfamily FOC91_28290 ENOG4105CSR polyphosphate kinase 2 FOC91_28340 ENOG4105FVX FOC91_28405 ENOG4105C6K Malic enzyme FOC91_28410 ENOG4108IJ0 Aspartate ammonia-lyase FOC91_28420 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC91_28440 ENOG4105CJ1 ABC, transporter FOC91_28475 ENOG4106BRA Membrane FOC91_28505 ENOG4107QIV Cytochrome c biogenesis protein FOC91_28525 ENOG4105EC3 peptidase S51, dipeptidase E FOC91_28530 ENOG4107QJQ Mate efflux family protein FOC91_28550 ENOG4105C9Q fumarate hydratase class II FOC91_28555 ENOG4105DFD Na H antiporter FOC91_28570 ENOG4108PJD permease FOC91_28575 ENOG4105CKI cobalamin synthesis protein FOC91_28580 ENOG4108UZ3 Transporter FOC91_28585 ENOG4105DRR Transcriptional regulator, GntR family FOC91_28595 ENOG4105PGM cation diffusion facilitator family transporter FOC91_28615 ENOG4105CAQ asparagine synthetase FOC91_28625 ENOG4105K56 Transcriptional regulator FOC91_28640 ENOG4105CVJ phosphoglycerate mutase FOC91_28690 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr FOC91_28705 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOC91_28710 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FOC91_28720 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC91_28750 ENOG4105KAC Antibiotic biosynthesis monooxygenase FOC91_28780 ENOG41062JF Transcriptional regulator FOC91_28805 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC91_28810 ENOG4105KTQ flagellar basal-body rod protein FOC91_28815 ENOG4105FZW flagellar biosynthesis regulator FlhF FOC91_28820 ENOG4105D7B Flagellar biosynthesis protein flha FOC91_28825 ENOG4105D00 flagellar biosynthetic protein flhB FOC91_28835 ENOG4105VS8 Flagellar biosynthetic protein fliq FOC91_28840 ENOG4105CN7 Flagellar biosynthetic protein FliP FOC91_28850 ENOG4105DD5 Flagellar motor switch protein FOC91_28855 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC91_28865 ENOG4105E4C Lytic transglycosylase catalytic FOC91_28870 ENOG4105I03 Flagellin FOC91_28875 ENOG4105I03 Flagellin FOC91_28885 ENOG4107R88 Chemotaxis protein (CheV) FOC91_28900 ENOG4105BZE flagellar hook protein, FlgE FOC91_28930 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC91_28935 ENOG4107U2N Flagellar M-ring protein FOC91_28945 ENOG4108ZC9 flagellar basal-body rod protein flgc FOC91_28950 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOC91_28965 ENOG4105DTS flagellar hook-associated FOC91_28970 ENOG4105DTJ flagellar hook-associated protein FOC91_28975 ENOG4105E1Q flagellar hook-associated protein FOC91_28995 ENOG4105BZU Histidine kinase FOC91_29010 ENOG4105DD5 Flagellar motor switch protein FOC91_29015 ENOG4105CBS Chea signal transduction histidine kinase FOC91_29020 ENOG4107YTP response regulator receiver protein FOC91_29025 ENOG4105ER2 Ompa motb domain protein FOC91_29030 ENOG4107R0U MotA TolQ exbB proton channel FOC91_29040 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC91_29095 ENOG41080C8 DUF218 domain FOC91_29100 ENOG4105H67 Protein of unknown function (DUF421) FOC91_29110 ENOG4108Z5V transcriptional regulator, merr family FOC91_29115 ENOG4105CN5 Metallo-Beta-Lactamase FOC91_29120 ENOG4107RWR Sodium hydrogen exchanger FOC91_29130 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC91_29195 ENOG41081VK Ribonuclease FOC91_29215 ENOG4108SZE gCN5-related N-acetyltransferase FOC91_29285 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase