locus-tag class description FOC92_00010 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC92_00015 ENOG4107QKG PfaD family FOC92_00020 ENOG4108151 Beta-lactamase domain protein FOC92_00045 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC92_00125 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC92_00150 ENOG41067FT ParB-like nuclease domain FOC92_00180 ENOG4105TRI Hydrolase FOC92_00220 ENOG4105IBP Cyclic peptide transporter FOC92_00225 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOC92_00230 ENOG4105C0W non-ribosomal peptide synthetase FOC92_00245 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) FOC92_00250 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC92_00265 ENOG4105C1G acyl-Coa dehydrogenase FOC92_00275 ENOG4105CEY Amp-dependent synthetase and ligase FOC92_00285 ENOG4105C0W non-ribosomal peptide synthetase FOC92_00285 ENOG4105C0W non-ribosomal peptide synthetase FOC92_00300 ENOG4107SDT Homocitrate synthase FOC92_00320 ENOG4105CUZ uba thif-type nad fad binding protein FOC92_00350 ENOG4107QJQ Mate efflux family protein FOC92_00355 ENOG4108WC5 Alpha Beta Hydrolase Fold protein FOC92_00360 ENOG41087PP glycosyltransferase MGT family FOC92_00365 ENOG4105KNA -acetyltransferase FOC92_00380 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) FOC92_00385 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) FOC92_00395 ENOG41080TC multidrug resistance protein FOC92_00420 ENOG4107SET aldo keto reductase FOC92_00440 ENOG4105CFF transcriptional regulator FOC92_00480 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FOC92_00495 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FOC92_00535 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC92_00590 ENOG4105K70 DNA-binding protein FOC92_00610 ENOG4107JM4 Tetratricopeptide repeat FOC92_00615 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC92_00690 ENOG4105CAQ asparagine synthetase FOC92_00695 ENOG4108RZE Tetr family transcriptional regulator FOC92_00785 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC92_00800 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FOC92_00805 ENOG4105DR5 peptidase FOC92_00810 ENOG41065S2 pneumococcal vaccine antigen FOC92_00900 ENOG4105E4C Lytic transglycosylase catalytic FOC92_00910 ENOG41069ER domain protein FOC92_00920 ENOG4107JM4 Tetratricopeptide repeat FOC92_00985 ENOG4105CJW magnesium transporter FOC92_01135 ENOG4105DQ6 Transposase FOC92_01205 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC92_01235 ENOG4105D7V transposase FOC92_01255 ENOG4105KRN Transcriptional regulator, abrb family FOC92_01320 ENOG4105D7V transposase FOC92_01345 ENOG4108IQI permease FOC92_01350 ENOG4108J5H Homocysteine s-methyltransferase FOC92_01360 ENOG4105BZU Histidine kinase FOC92_01365 ENOG4105C19 ABC transporter FOC92_01375 ENOG4105DNP FAD linked oxidase domain protein FOC92_01415 ENOG4105BZ4 penicillin-binding protein FOC92_01425 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC92_01445 ENOG4105DVH amino acid FOC92_01460 ENOG4105MZU cell filamentation protein FOC92_01465 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC92_01480 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC92_01490 ENOG4106A3M Cytochrome p-450 FOC92_01510 ENOG4107RA9 decarboxylase FOC92_01555 ENOG4107SCK Monooxygenase FOC92_01560 ENOG4108IFG nitrite reductase, (NAD(P)H) FOC92_01565 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOC92_01570 ENOG4107QHE Choloylglycine hydrolase FOC92_01580 ENOG4108NHD germination protein FOC92_01590 ENOG4105VEQ Cold shock protein FOC92_01610 ENOG4108VJ1 Transcriptional regulator (CarD family FOC92_01640 ENOG4105DRR Transcriptional regulator, GntR family FOC92_01665 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) FOC92_01675 ENOG4108JJA ABC, transporter FOC92_01705 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC92_01745 ENOG4105PF9 Transcriptional regulator FOC92_01750 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC92_01755 ENOG4105C0W non-ribosomal peptide synthetase FOC92_01760 ENOG4107SQU synthase FOC92_01765 ENOG4107SQU synthase FOC92_01770 ENOG4105C0W non-ribosomal peptide synthetase FOC92_01775 ENOG4105C0W non-ribosomal peptide synthetase FOC92_01780 ENOG4107SQU synthase FOC92_01785 ENOG4105C0W non-ribosomal peptide synthetase FOC92_01800 ENOG4108KS4 Spore coat protein FOC92_01805 ENOG4107SBE Glycosyl transferase (Group 1 FOC92_01825 ENOG4107SBE Glycosyl transferase (Group 1 FOC92_01830 ENOG4108IAJ Nad-dependent epimerase dehydratase FOC92_02060 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC92_02095 ENOG4105F6J Alpha beta hydrolase fold FOC92_02110 ENOG4105F6J Alpha beta hydrolase fold FOC92_02135 ENOG4105XT2 Transcriptional regulator FOC92_02160 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC92_02170 ENOG4107RSM transcriptional regulator FOC92_02175 ENOG4107AYK membrAne FOC92_02180 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC92_02190 ENOG4105K70 DNA-binding protein FOC92_02210 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC92_02245 ENOG4108W2Y isochorismatase FOC92_02265 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) FOC92_02275 ENOG4105ST3 Transcriptional regulator FOC92_02365 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC92_02370 ENOG4108BUD transposase FOC92_02380 ENOG4105C19 ABC transporter FOC92_02395 ENOG41081I9 integral membrane protein FOC92_02410 ENOG4108BUD transposase FOC92_02420 ENOG410780I phosphoprotein phosphatase activity FOC92_02500 ENOG4105NA0 Transcriptional regulator FOC92_02505 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC92_02550 ENOG4107SWG transcriptional regulator MERR family FOC92_02555 ENOG4105KNA -acetyltransferase FOC92_02565 ENOG4105CE7 Amidase, hydantoinase carbamoylase family FOC92_02575 ENOG4105G9B Transcriptional regulator FOC92_02685 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) FOC92_02700 ENOG4105BZ1 (ABC) transporter FOC92_02710 ENOG4108WUH Transcriptional regulator, TetR family FOC92_02730 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC92_02740 ENOG4107RN3 metallophosphoesterase FOC92_02775 ENOG4108VHC Short-chain dehydrogenase reductase Sdr FOC92_02780 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC92_02865 ENOG4105D7V transposase FOC92_02900 ENOG4108IAJ Nad-dependent epimerase dehydratase FOC92_02905 ENOG4107QQG Dehydrogenase FOC92_02965 ENOG4105CK5 oxidoreductase FOC92_02970 ENOG4105CK5 oxidoreductase FOC92_02990 ENOG4105CNU cell division protein FtsK FOC92_03150 ENOG4105CID antiterminator FOC92_03155 ENOG4105C5Y PTS System FOC92_03160 ENOG4105CS2 ec 3.2.1.21 FOC92_03260 ENOG4105EKQ RNA-directed DNA polymerase FOC92_03300 ENOG4105D7V transposase FOC92_03325 ENOG4105WKZ CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) FOC92_03340 ENOG4105DHF Membrane FOC92_03410 ENOG4105CSH Transporter FOC92_03420 ENOG4105CKK Glycosyl transferase, family 2 FOC92_03445 ENOG4105C8Y Acetylornithine aminotransferase FOC92_03490 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC92_03575 ENOG4108TVJ Nitroreductase FOC92_03580 ENOG4105FS7 Transcriptional regulator FOC92_03620 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) FOC92_03625 ENOG4108XET gCN5-related N-acetyltransferase FOC92_03640 ENOG4108PCN EamA-like transporter family FOC92_03685 ENOG410635A Membrane FOC92_03695 ENOG4108IQI permease FOC92_03705 ENOG4105F1N DNA alkylation repair FOC92_03740 ENOG4107RF6 penicillin-binding protein FOC92_03745 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FOC92_03765 ENOG4105E7W lamb ycsf family protein FOC92_03775 ENOG4105P4J Allophanate hydrolase, subunit 1 FOC92_03780 ENOG4107258 Transcriptional regulator FOC92_03790 ENOG4106N3A copper homeostasis protein cutc FOC92_03795 ENOG4108ZHR arsR family transcriptional regulator FOC92_03805 ENOG4105FDT acyl-CoA dehydrogenase FOC92_03820 ENOG4105DWD nucleoside recognition domain protein FOC92_03855 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOC92_03880 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC92_03905 ENOG4105E2A Dehydrogenase FOC92_03915 ENOG4108IJ0 Aspartate ammonia-lyase FOC92_03920 ENOG4105HDK L-asparaginase FOC92_03925 ENOG4108IMY Transcriptional regulator FOC92_03950 ENOG4108B31 Spore germination protein FOC92_03960 ENOG4105BZU Histidine kinase FOC92_03985 ENOG41075H3 AraC family transcriptional regulator FOC92_03995 ENOG4105YWU small acid-soluble spore protein FOC92_04000 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC92_04005 ENOG4105CUB amino acid FOC92_04010 ENOG4105II7 pyrroline-5-carboxylate reductase FOC92_04015 ENOG4108NHD germination protein FOC92_04020 ENOG4108Q8B Spore germination protein FOC92_04070 ENOG4105CGH 5'-nucleotidase FOC92_04080 ENOG4105CHJ isochorismatase hydrolase FOC92_04105 ENOG4105EQ0 Major Facilitator superfamily FOC92_04160 ENOG4105F6J Alpha beta hydrolase fold FOC92_04175 ENOG4108606 TspO/MBR family FOC92_04180 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOC92_04195 ENOG4108TWJ NADH dehydrogenase subunit 5 FOC92_04200 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FOC92_04205 ENOG4105F27 Major Facilitator FOC92_04210 ENOG4106P55 Transcriptional regulator FOC92_04225 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FOC92_04230 ENOG4105BZU Histidine kinase FOC92_04235 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC92_04260 ENOG4108VJ1 Transcriptional regulator (CarD family FOC92_04275 ENOG4105FR1 rard protein FOC92_04310 ENOG41062ES Transcriptional regulator FOC92_04315 ENOG4105C57 major facilitator superfamily FOC92_04330 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC92_04335 ENOG4105ECQ AraC Family Transcriptional Regulator FOC92_04340 ENOG4105Z7P Acetyltransferase (GNAT) family FOC92_04350 ENOG4105D6J arsenicaL-resistance protein FOC92_04355 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC92_04360 ENOG41085FC arsR family transcriptional regulator FOC92_04385 ENOG4105NAE bifunctional deaminase-reductase domain protein FOC92_04410 ENOG4107P5I polyketide synthase FOC92_04415 ENOG4108IG5 Transcriptional regulator FOC92_04420 ENOG4108JGH Tetr family transcriptional regulator FOC92_04425 ENOG4105EQ0 Major Facilitator superfamily FOC92_04445 ENOG4105F27 Major Facilitator FOC92_04450 ENOG4105M4P Tetr family transcriptional regulator FOC92_04455 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FOC92_04460 ENOG4108YXU transcriptional regulator AsnC family FOC92_04555 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOC92_04560 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC92_04575 ENOG4105K6H D-cysteine desulfhydrase FOC92_04585 ENOG4105E0Y RtcB Protein FOC92_04595 ENOG4105JQZ Methyltransferase FOC92_04615 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FOC92_04635 ENOG4105BZU Histidine kinase FOC92_04645 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC92_04680 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FOC92_04715 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC92_04835 ENOG4108VXD carboxy-peptidase FOC92_04840 ENOG4105PNM synthesis protein FOC92_04850 ENOG4108ISG Major Facilitator FOC92_04865 ENOG4107MII Sugar-specific transcriptional regulator TrmB FOC92_04870 ENOG4105CZM Major Facilitator FOC92_04885 ENOG4105CRW Short chain fatty acid transporter FOC92_04895 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC92_04955 ENOG4108K8S endonuclease I FOC92_04975 ENOG4108Z66 YbaK ebsC protein FOC92_04980 ENOG4105CUT histidyl-tRNA synthetase FOC92_04995 ENOG4105KVH Transcriptional regulator FOC92_05000 ENOG4108RCM Nitroreductase FOC92_05030 ENOG4108PSK reductase FOC92_05145 ENOG4105EV4 Multidrug resistance protein mdtH FOC92_05175 ENOG4105C37 (CBS) domain FOC92_05190 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FOC92_05195 ENOG4105FAW cDP-glucose 4,6-dehydratase FOC92_05225 ENOG4105DDN Pentapeptide repeat-containing protein FOC92_05230 ENOG4105XDF Protein of unknown function (DUF1272) FOC92_05235 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOC92_05240 ENOG4105CMG Carbohydrate kinase FOC92_05245 ENOG4105C6Z Gluconate FOC92_05250 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC92_05260 ENOG4105CV1 Transketolase (EC 2.2.1.1) FOC92_05265 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC92_05290 ENOG4105C8Q Methyl-accepting chemotaxis FOC92_05295 ENOG4108UX3 '-nucleotidase FOC92_05300 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC92_05305 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FOC92_05310 ENOG4105KVH Transcriptional regulator FOC92_05335 ENOG4105C44 Serine transporter FOC92_05365 ENOG4108TZY GntR Family Transcriptional Regulator FOC92_05370 ENOG4105D9R oxidoreductase FOC92_05410 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC92_05420 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FOC92_05425 ENOG4105KVH Transcriptional regulator FOC92_05480 ENOG410829K Lysine exporter protein (Lyse ygga) FOC92_05500 ENOG4105KAF membrAne FOC92_05530 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FOC92_05555 ENOG4105H3G oxidoreductase FOC92_05625 ENOG4108TN2 lmbE family FOC92_05635 ENOG4107R3E Citrate transporter FOC92_05645 ENOG4105WCN acetyltransferase FOC92_05650 ENOG4108MES Periplasmic binding protein FOC92_05655 ENOG4105EHG Permease protein FOC92_05660 ENOG4105DQ5 transport system permease protein FOC92_05685 ENOG41068WN FOC92_05690 ENOG4107CUJ Protein of unknown function (DUF2690) FOC92_05700 ENOG4107V2S Transcriptional regulator FOC92_05710 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC92_05725 ENOG4105C98 muts2 protein FOC92_05735 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FOC92_05740 ENOG4105DPN Oligoendopeptidase f FOC92_05745 ENOG4108A04 Beta-lactamase FOC92_05770 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC92_05780 ENOG41082BM Transcriptional regulator, arsr family FOC92_05785 ENOG4105CIS alcohol dehydrogenase FOC92_05810 ENOG4105CQB FAD linked oxidase domain protein FOC92_05835 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC92_05840 ENOG4107TPS domain protein FOC92_05845 ENOG4105CEP NADH dehydrogenase FOC92_05855 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C FOC92_05860 ENOG4108M1A Chitin-binding protein FOC92_05870 ENOG4105E1K spore germination protein FOC92_05890 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FOC92_05900 ENOG4108IAJ Nad-dependent epimerase dehydratase FOC92_05905 ENOG4105FAW cDP-glucose 4,6-dehydratase FOC92_05910 ENOG4105D7V transposase FOC92_05970 ENOG4105BZU Histidine kinase FOC92_05975 ENOG4105C5H ABC transporter FOC92_05985 ENOG4107DUR UPF0457 protein FOC92_06005 ENOG4105BZU Histidine kinase FOC92_06015 ENOG4105KT7 mgtC SapB transporter FOC92_06025 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC92_06030 ENOG41073R8 VanW family FOC92_06040 ENOG4108R1P FOC92_06055 ENOG4105VEQ Cold shock protein FOC92_06080 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOC92_06100 ENOG410904N short-chain dehydrogenase reductase FOC92_06110 ENOG4106IQC argininosuccinate lyase FOC92_06125 ENOG4108IA2 Sodium pantothenate symporter FOC92_06135 ENOG4105C26 Dehydrogenase FOC92_06140 ENOG4105CHR reductase FOC92_06150 ENOG4105EWU Squalene--hopene cyclase FOC92_06160 ENOG4105FR1 rard protein FOC92_06165 ENOG410696E Membrane FOC92_06180 ENOG4105D1F ATP-binding protein FOC92_06190 ENOG4108ZAF Molybdopterin FOC92_06195 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC92_06200 ENOG4105D06 uba thif-type nad fad binding protein FOC92_06205 ENOG4105TMB Formate nitrite transporter FOC92_06215 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC92_06220 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FOC92_06230 ENOG4108JB9 formate dehydrogenase FOC92_06235 ENOG4105E1K spore germination protein FOC92_06250 ENOG4105CUB amino acid FOC92_06305 ENOG4108KGH TRANSCRIPTIONal FOC92_06315 ENOG4105EMN RNA polymerase sigma factor FOC92_06325 ENOG4105CIG ABC transporter FOC92_06345 ENOG4105D9R oxidoreductase FOC92_06355 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC92_06360 ENOG4105K4P CoA-binding domain protein FOC92_06365 ENOG4105C0H protease FOC92_06370 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC92_06380 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOC92_06390 ENOG4105W8X HesB YadR YfhF-family protein FOC92_06420 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC92_06425 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC92_06440 ENOG4105BZ1 (ABC) transporter FOC92_06445 ENOG4108I0Z Aconitate hydratase FOC92_06475 ENOG4105E5W Transporter FOC92_06485 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC92_06505 ENOG4107F3J Amp-dependent synthetase and ligase FOC92_06510 ENOG4107ZYJ bioY protein FOC92_06515 ENOG4105CEY Amp-dependent synthetase and ligase FOC92_06520 ENOG4108IMY Transcriptional regulator FOC92_06545 ENOG4105D9G High-affinity FOC92_06550 ENOG4105IW1 AmiS UreI transporter FOC92_06565 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) FOC92_06605 ENOG4107AYK membrAne FOC92_06615 ENOG4105BZU Histidine kinase FOC92_06620 ENOG4105FBA Phospholipase Carboxylesterase FOC92_06625 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FOC92_06635 ENOG4105CBC glutamate synthase FOC92_06640 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC92_06645 ENOG4108VJ1 Transcriptional regulator (CarD family FOC92_06650 ENOG4108903 Formimidoylglutamase FOC92_06660 ENOG4105CGP Urocanate hydratase FOC92_06675 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) FOC92_06680 ENOG4108Z0Z intracellular protease Pfpi family FOC92_06705 ENOG4107QIV Cytochrome c biogenesis protein FOC92_06725 ENOG4105CJ1 ABC, transporter FOC92_06740 ENOG4107RSM transcriptional regulator FOC92_06750 ENOG41067MG lrgb family FOC92_06790 ENOG4105BZ1 (ABC) transporter FOC92_06795 ENOG4105BZ1 (ABC) transporter FOC92_06830 ENOG4108HW3 (ABC) transporter FOC92_06835 ENOG4105CGH 5'-nucleotidase FOC92_06845 ENOG4108SVB resolvase FOC92_06865 ENOG4105K7K Transcriptional regulator FOC92_06870 ENOG4105C5F glutamine synthetase FOC92_06875 ENOG4105KV4 Transcriptional regulator FOC92_06880 ENOG4105CXI aluminum resistance protein FOC92_06885 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC92_06890 ENOG4105EN6 Membrane FOC92_06900 ENOG4106F1P AAA ATPase, central domain protein FOC92_06930 ENOG41069ER domain protein FOC92_06935 ENOG4105DM4 PTS System FOC92_06940 ENOG4105DE4 1-phosphofructokinase FOC92_06945 ENOG4105E98 transcriptional regulator DeoR family FOC92_06950 ENOG4107QW4 alcohol dehydrogenase FOC92_06955 ENOG4108SJC Membrane FOC92_06965 ENOG4105C85 amino acid FOC92_06980 ENOG4105TMB Formate nitrite transporter FOC92_06985 ENOG4105K70 DNA-binding protein FOC92_06995 ENOG4105C59 p-type ATPase FOC92_07000 ENOG410681U heavy metal transport detoxification protein FOC92_07005 ENOG4105VPX protein, conserved in bacteria FOC92_07015 ENOG4105NIV Esterase FOC92_07020 ENOG4105E0A ABC, transporter FOC92_07050 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC92_07055 ENOG4105D03 DNA-3-methyladenine glycosylase II FOC92_07080 ENOG4105BZU Histidine kinase FOC92_07100 ENOG4105C5E polysaccharide biosynthesis protein FOC92_07120 ENOG41067MG lrgb family FOC92_07140 ENOG4108S3Y transcriptional regulator FOC92_07145 ENOG4105CS2 ec 3.2.1.21 FOC92_07150 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C FOC92_07160 ENOG4105F0V Cell wall hydrolase FOC92_07170 ENOG4105E0M Sulfatase FOC92_07175 ENOG410890F Dynamin family FOC92_07210 ENOG4105DQU oxidoreductase, subunit beta FOC92_07215 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FOC92_07220 ENOG4108IGT Dipeptidase FOC92_07225 ENOG4105MCT stage V sporulation protein S FOC92_07230 ENOG4105D48 metallophosphoesterase FOC92_07260 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOC92_07275 ENOG4105XZV Protein of unknown function (DUF3243) FOC92_07280 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FOC92_07300 ENOG4105UIB (ABC) transporter FOC92_07305 ENOG4108JQ9 ABC transporter FOC92_07310 ENOG4105DIH basic membrane FOC92_07315 ENOG4105FDP GntR family transcriptional regulator FOC92_07320 ENOG4105CNU cell division protein FtsK FOC92_07330 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FOC92_07340 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC92_07350 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC92_07355 ENOG4108S0H Dipicolinic acid synthetase, b subunit FOC92_07360 ENOG4105E35 Dipicolinate synthase subunit A FOC92_07370 ENOG4105C1V Peptidase, M16 FOC92_07390 ENOG4105DTN riboflavin biosynthesis protein ribF FOC92_07405 ENOG4105W7A Protein of unknown function (DUF503) FOC92_07415 ENOG4105VHM ribosomal protein FOC92_07420 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FOC92_07425 ENOG4105CHV Transcription elongation factor NusA FOC92_07435 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC92_07445 ENOG4105DZP Membrane-associated zinc metalloprotease FOC92_07450 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOC92_07455 ENOG4105KNE Phosphatidate cytidylyltransferase FOC92_07460 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FOC92_07470 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC92_07500 ENOG4108HE4 integrase family FOC92_07510 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOC92_07515 ENOG4105C79 DNA protecting protein DprA FOC92_07520 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOC92_07535 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FOC92_07560 ENOG4105VB6 UPF0109 protein FOC92_07580 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOC92_07585 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOC92_07600 ENOG4105CHR reductase FOC92_07605 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC92_07620 ENOG4105CB5 ATP-dependent DNA helicase recG FOC92_07625 ENOG4105DP4 dak2 domain fusion protein ylov FOC92_07630 ENOG4108ZAA Alkaline-shock protein FOC92_07645 ENOG4105FJ0 thiamine FOC92_07650 ENOG4105DJV ribulose-phosphate 3-epimerase FOC92_07655 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC92_07660 ENOG4105D9P serine threonine protein kinase FOC92_07665 ENOG4108ZF3 Phosphatase FOC92_07675 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOC92_07690 ENOG4105C25 Primosomal protein n' FOC92_07695 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOC92_07715 ENOG4105DSJ YicC domain protein FOC92_07735 ENOG4105DC7 peptidase M24 FOC92_07770 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) FOC92_07775 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FOC92_07785 ENOG4105CD3 dihydroorotase FOC92_07805 ENOG4105C34 Pseudouridine synthase FOC92_07830 ENOG4105DBK s4 domain protein FOC92_07835 ENOG41067XK integral membrane protein FOC92_07845 ENOG4105DFA alanine racemase domain protein FOC92_07850 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOC92_07855 ENOG4105WR5 sporulation protein, YlmC YmxH family FOC92_07865 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC92_07875 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOC92_07880 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOC92_07890 ENOG4105D4A Cell wall formation (By similarity) FOC92_07895 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC92_07900 ENOG4105CNI cell division protein FtsW FOC92_07915 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC92_07920 ENOG4105CJN penicillin-binding protein FOC92_07925 ENOG4105CJN penicillin-binding protein FOC92_07940 ENOG41074B2 UPF0747 protein FOC92_07965 ENOG4105KNH Nucleic acid-binding protein FOC92_07975 ENOG41063PX domain protein FOC92_07980 ENOG4105D78 K07001 NTE family protein FOC92_07985 ENOG4105H20 Sporulation integral membrane protein YlbJ FOC92_07995 ENOG4106H78 methyltransferase FOC92_08015 ENOG4107TB6 phosphoglycerate mutase FOC92_08030 ENOG4106UY4 Inherit from COG: Scp-like extracellular FOC92_08080 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FOC92_08085 ENOG4105CNI cell division protein FtsW FOC92_08100 ENOG4108IAB Phoh family FOC92_08120 ENOG4105QA2 FOC92_08125 ENOG4105CI3 gtp-binding protein typa FOC92_08135 ENOG4105ECY inositol monophosphatase FOC92_08155 ENOG4105CXN decarboxylase FOC92_08205 ENOG4105CPP Dehydrogenase, E1 component FOC92_08220 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC92_08225 ENOG4108X4Q Hydrolase FOC92_08235 ENOG4105CN5 Metallo-Beta-Lactamase FOC92_08240 ENOG4107ZYR domain protein FOC92_08275 ENOG4108XRC Protein of unknown function (DUF458) FOC92_08285 ENOG4107IN1 Protein of unknown function (DUF1797) FOC92_08300 ENOG4105EPM Diguanylate phosphodiesterase FOC92_08305 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FOC92_08320 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FOC92_08330 ENOG4105UIN FOC92_08365 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FOC92_08385 ENOG4108HGU Histidine kinase FOC92_08395 ENOG4105CHM Aminotransferase FOC92_08400 ENOG4105FKQ transcriptional regulator FOC92_08405 ENOG4105EG2 ABC transporter, permease FOC92_08415 ENOG4107FKK extracellular solute-binding protein family 1 FOC92_08425 ENOG4105CG3 alpha amylase, catalytic region FOC92_08470 ENOG4105CHU acetyl-coa acetyltransferase FOC92_08500 ENOG4105K7K Transcriptional regulator FOC92_08505 ENOG4105DTD Dehydrogenase FOC92_08525 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOC92_08550 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FOC92_08565 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC92_08575 ENOG4105BZU Histidine kinase FOC92_08595 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOC92_08610 ENOG4105CID antiterminator FOC92_08630 ENOG4105CE4 GlcNAc 6-P deacetylase FOC92_08665 ENOG4107ZE5 PPIases accelerate the folding of proteins FOC92_08670 ENOG4105PTM secreted protein FOC92_08675 ENOG4105J7I hydrolase FOC92_08685 ENOG4105G6R Stage v sporulation protein ae FOC92_08695 ENOG4105CZ3 stage V sporulation protein ad FOC92_08700 ENOG41090VF Stage v sporulation protein ac FOC92_08720 ENOG4105C8J )-transporter FOC92_08725 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC92_08735 ENOG41082AN stage II sporulation protein FOC92_08740 ENOG4105DZ1 carboxypeptidase FOC92_08745 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC92_08750 ENOG4105DVE abc transporter atp-binding protein FOC92_08780 ENOG4105D7N magnesium and cobalt transport protein CorA FOC92_08805 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC92_08815 ENOG4105I3K Ferric uptake regulator, Fur family FOC92_08820 ENOG4105MZ9 stage II sporulation protein m FOC92_08840 ENOG4105CPC Aldo Keto reductase FOC92_08850 ENOG4105RHY Pfam:UPF0157 FOC92_08870 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC92_08880 ENOG4105ETE Transcriptional regulator (LacI family FOC92_08885 ENOG4108YM7 Gcn5-related n-acetyltransferase FOC92_08905 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC92_08910 ENOG4108R6K riboflavin synthase, subunit alpha FOC92_08935 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC92_08940 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC92_08955 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC92_08965 ENOG4105DFD Na H antiporter FOC92_08970 ENOG4105CGH 5'-nucleotidase FOC92_08995 ENOG4105DBV ornithine carbamoyltransferase FOC92_09010 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FOC92_09025 ENOG4108IXY short-chain dehydrogenase reductase FOC92_09030 ENOG41069FQ Metallo-beta-lactamase superfamily FOC92_09035 ENOG4105II7 pyrroline-5-carboxylate reductase FOC92_09040 ENOG4105EJQ L-serine dehydratase FOC92_09055 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOC92_09070 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FOC92_09085 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOC92_09090 ENOG4105D9U N-acetyltransferase FOC92_09105 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FOC92_09110 ENOG4108QEG Membrane FOC92_09115 ENOG4105CDA abc transporter atp-binding protein FOC92_09120 ENOG4105E5Q amino acid AbC transporter FOC92_09125 ENOG4108HW3 (ABC) transporter FOC92_09135 ENOG4105G7B Protein of unknown function (DUF2992) FOC92_09145 ENOG4108QY0 Membrane FOC92_09155 ENOG4105C7S Dehydrogenase FOC92_09160 ENOG4105CPP Dehydrogenase, E1 component FOC92_09180 ENOG4107RDP Dehydrogenase FOC92_09190 ENOG4108JUB Transcriptional regulator FOC92_09200 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC92_09215 ENOG4107QQR Sporulation FOC92_09220 ENOG4105S1Z Stage IV sporulation protein B FOC92_09225 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOC92_09230 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FOC92_09235 ENOG4105DX0 Hemolysin A FOC92_09245 ENOG4105CTB Polyprenyl synthetase FOC92_09260 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FOC92_09270 ENOG4108ZSR alkaline shock protein FOC92_09275 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC92_09300 ENOG410644B Stage III sporulation protein af FOC92_09310 ENOG4105KQ4 Stage iii sporulation protein ad FOC92_09315 ENOG4108CQH stage III sporulation protein AC FOC92_09320 ENOG4105KR5 Stage iii sporulation protein FOC92_09325 ENOG4105CD2 stage iii sporulation protein aa FOC92_09350 ENOG4105DC7 peptidase M24 FOC92_09355 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FOC92_09365 ENOG4105CBJ Metal-dependent enzyme FOC92_09375 ENOG4107YBY Hydrolase FOC92_09405 ENOG41082GG biotin lipoate A B protein ligase FOC92_09410 ENOG4105WZW rhodanese family FOC92_09435 ENOG41080TC multidrug resistance protein FOC92_09465 ENOG4105CJ1 ABC, transporter FOC92_09470 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC92_09500 ENOG4105C0D helicase FOC92_09620 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC92_09625 ENOG4105C3R Methionine synthase FOC92_09635 ENOG4105C28 cystathionine FOC92_09640 ENOG4105C28 cystathionine FOC92_09660 ENOG4105C5X domain protein FOC92_09670 ENOG4105DKQ ROK family FOC92_09680 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOC92_09695 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOC92_09700 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FOC92_09705 ENOG4105C8U phosphate abc transporter FOC92_09710 ENOG4105C8U phosphate abc transporter FOC92_09720 ENOG4107RF6 penicillin-binding protein FOC92_09730 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC92_09755 ENOG4105N80 Ferric uptake regulator, Fur family FOC92_09765 ENOG4105FDK ABC transporter FOC92_09770 ENOG4108JYZ YitT family FOC92_09775 ENOG41069ZM Protein of unknown function (DUF2624) FOC92_09800 ENOG4105EGD dinuclear metal center protein, YbgI family FOC92_09815 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC92_09820 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOC92_09850 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOC92_09855 ENOG4105KG3 cytidine deaminase FOC92_09860 ENOG4107YR5 Diacylglycerol kinase FOC92_09870 ENOG4105CTJ Metal Dependent Phosphohydrolase FOC92_09875 ENOG4105C9A Phoh family FOC92_09885 ENOG41068P3 sporulation protein YqfC FOC92_09890 ENOG4105KTH gatB Yqey FOC92_09900 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC92_09905 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOC92_09935 ENOG4105CSA Coproporphyrinogen iii oxidase FOC92_09940 ENOG4105KVH Transcriptional regulator FOC92_09965 ENOG4105TQK DNA polymerase iii, delta' subunit FOC92_09975 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC92_09980 ENOG4108UK2 deaminase FOC92_09985 ENOG4105KQC Competence protein FOC92_09995 ENOG4105DXX methyltransferase FOC92_10005 ENOG4108WF2 Metal Dependent Phosphohydrolase FOC92_10015 ENOG410812S Rna-binding protein FOC92_10025 ENOG4105CQW ribosome biogenesis GTPase YqeH FOC92_10030 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FOC92_10045 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC92_10065 ENOG4108TVJ Nitroreductase FOC92_10080 ENOG4105G6Z alkaline phosphatase FOC92_10085 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FOC92_10090 ENOG4108MUZ hydrolase FOC92_10120 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC92_10125 ENOG4105MIR Phenylalanine 4-monooxygenase FOC92_10135 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC92_10175 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC92_10180 ENOG4108V5C ABC transporter FOC92_10190 ENOG4105C0A alcohol dehydrogenase FOC92_10195 ENOG4105C28 cystathionine FOC92_10225 ENOG4107XRG penicillin-binding protein FOC92_10235 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FOC92_10245 ENOG4105CFP Peptidase U32 FOC92_10250 ENOG4105XYU peptidase (U32 family) FOC92_10260 ENOG4105HHA aminodeoxychorismate lyase FOC92_10280 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC92_10290 ENOG4105C02 permease FOC92_10305 ENOG41060CR FOC92_10310 ENOG4105C7H Helicase, RecD TraA family FOC92_10320 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FOC92_10325 ENOG4105C3J Cysteine desulfurase FOC92_10335 ENOG4105D1H recombination factor protein RarA FOC92_10340 ENOG4108VCI transcription factor, rsfa family FOC92_10345 ENOG4105CUZ uba thif-type nad fad binding protein FOC92_10355 ENOG4105CUT histidyl-tRNA synthetase FOC92_10365 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FOC92_10370 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC92_10380 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC92_10385 ENOG41076HS cation diffusion facilitator family transporter FOC92_10390 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC92_10400 ENOG4105CKP Polysaccharide Biosynthesis Protein FOC92_10405 ENOG4108QG2 Membrane FOC92_10415 ENOG4105VIE preprotein translocase, subunit YajC FOC92_10430 ENOG41061AI Protein of unknown function (DUF2905) FOC92_10445 ENOG4108HUF Transporter FOC92_10475 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FOC92_10480 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOC92_10485 ENOG4108IYU L-aspartate oxidase FOC92_10500 ENOG4108RPX mosc domain containing protein FOC92_10505 ENOG4105CQC Prephenate dehydratase FOC92_10520 ENOG4105C19 ABC transporter FOC92_10525 ENOG4105EWM Histidine kinase FOC92_10535 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FOC92_10550 ENOG4105X36 (ribosomal) protein FOC92_10560 ENOG4105C03 ribonuclease FOC92_10575 ENOG4107QMS site-determining protein FOC92_10595 ENOG4105DFF Rod shape-determining protein mreb FOC92_10615 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC92_10620 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FOC92_10630 ENOG41068KH stage VI sporulation protein D FOC92_10640 ENOG4105D52 delta-aminolevulinic acid dehydratase FOC92_10665 ENOG4105K56 Transcriptional regulator FOC92_10685 ENOG4108IUQ atp-dependent protease FOC92_10710 ENOG4108QCI YvbH-like oligomerisation region FOC92_10730 ENOG4105M59 Phosphodiesterase, mj0936 family FOC92_10745 ENOG4108XJQ germination protein FOC92_10760 ENOG4105PFC Transcriptional regulator FOC92_10770 ENOG4105DZC cytosine deaminase FOC92_10775 ENOG41067S9 phage shock protein C, PspC FOC92_10780 ENOG4108JCI Transcriptional regulator FOC92_10790 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOC92_10795 ENOG4108Z40 Transcriptional regulator FOC92_10800 ENOG4105RHA ABC transporter, permease FOC92_10805 ENOG4108IUX (ABC) transporter FOC92_10810 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FOC92_10815 ENOG4105ER2 Ompa motb domain protein FOC92_10820 ENOG4105E14 MotA TolQ exbB proton channel FOC92_10825 ENOG4108VXD carboxy-peptidase FOC92_10835 ENOG4105E33 succinate dehydrogenase FOC92_10845 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FOC92_10855 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC92_10860 ENOG4105K63 Thioredoxin FOC92_10865 ENOG4105C10 Electron transfer flavoprotein FOC92_10870 ENOG4105BZJ Electron transfer flavoprotein FOC92_10875 ENOG41060WC Enoyl-CoA hydratase FOC92_10880 ENOG4107Z3H Transcriptional regulator, TetR family FOC92_10885 ENOG4105CEY Amp-dependent synthetase and ligase FOC92_10950 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC92_10965 ENOG4105DR4 Methyltransferase FOC92_10975 ENOG4105KFN sortase, SrtB family FOC92_10980 ENOG4105E0A ABC, transporter FOC92_10995 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FOC92_11005 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FOC92_11015 ENOG4105FE9 pseudouridine synthase FOC92_11025 ENOG4105DCG PHP domain protein FOC92_11040 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FOC92_11060 ENOG4105C5S asparaginyl-tRNA synthetase FOC92_11065 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FOC92_11075 ENOG4108RWN rrna methyltransferase FOC92_11105 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC92_11110 ENOG4105CW7 secretion protein, HlyD family FOC92_11115 ENOG4108JGH Tetr family transcriptional regulator FOC92_11120 ENOG4105CN9 Peptidase m42 family protein FOC92_11140 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FOC92_11145 ENOG4105C22 threonyL-tRNA synthetase FOC92_11150 ENOG4108TDW sporulation protein YtxC FOC92_11180 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOC92_11185 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOC92_11195 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FOC92_11200 ENOG4105C2M dna polymerase I FOC92_11205 ENOG4105BZU Histidine kinase FOC92_11210 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC92_11230 ENOG4108HMX isocitrate dehydrogenase (NADP) FOC92_11235 ENOG4105BZN citrate synthase FOC92_11245 ENOG4108REF Sporulation integral membrane protein ytvi FOC92_11250 ENOG4105FS0 cytoplasmic membrane protein FOC92_11275 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC92_11280 ENOG4105C6K Malic enzyme FOC92_11285 ENOG4105C0B DNA polymerase III (alpha subunit) FOC92_11290 ENOG4105VV2 FOC92_11300 ENOG4105SFS phosphoesterase RecJ domain protein FOC92_11325 ENOG4105E8R UPF0173 metal-dependent hydrolase FOC92_11330 ENOG4105DC7 peptidase M24 FOC92_11370 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC92_11390 ENOG4107YZX Universal stress protein FOC92_11425 ENOG4108JYZ YitT family FOC92_11445 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FOC92_11455 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FOC92_11460 ENOG4105KBJ sporulation protein ytfj FOC92_11475 ENOG4105EFZ amidohydrolase FOC92_11485 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC92_11510 ENOG4105RQF LysR family Transcriptional regulator FOC92_11520 ENOG4105U5Y Transcriptional regulator FOC92_11530 ENOG4105C28 cystathionine FOC92_11685 ENOG4105EMN RNA polymerase sigma factor FOC92_11695 ENOG4108UW5 maltose o-acetyltransferase FOC92_11705 ENOG4105F1V Acetoin utilization protein FOC92_11710 ENOG4105W87 Cbs domain FOC92_11715 ENOG4105DGU Histone deacetylase FOC92_11730 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC92_11735 ENOG4105BZU Histidine kinase FOC92_11740 ENOG4107SNB ankyrin repeat protein YahD FOC92_11745 ENOG4105EP9 oxidoreductase FOC92_11765 ENOG4105ETE Transcriptional regulator (LacI family FOC92_11770 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC92_11790 ENOG4105C88 aminopeptidase FOC92_11825 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FOC92_11835 ENOG4108VDD TRNA binding domain protein FOC92_11865 ENOG4105C8F Beta-lactamase domain protein FOC92_11880 ENOG4108V15 phosphotransferase enzyme family FOC92_11885 ENOG4108IUM Glycogen debranching enzyme FOC92_11895 ENOG4107QSE Dipeptidase FOC92_11900 ENOG4105YW5 deoR family transcriptional regulator FOC92_11915 ENOG4105CBX hi0933 family FOC92_11950 ENOG4108VJ1 Transcriptional regulator (CarD family FOC92_11955 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC92_11960 ENOG4105CSC Glucose uptake protein FOC92_11975 ENOG4108ZAF Molybdopterin FOC92_11980 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FOC92_11985 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC92_11995 ENOG4105D06 uba thif-type nad fad binding protein FOC92_12000 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC92_12020 ENOG41085GJ domain protein FOC92_12030 ENOG4105DWV Homoserine O-trans-acetylase FOC92_12040 ENOG4108B31 Spore germination protein FOC92_12070 ENOG4105C8T Leucyl-tRNA synthetase FOC92_12075 ENOG410605W Major Facilitator FOC92_12080 ENOG4107S91 Sodium hydrogen exchanger FOC92_12085 ENOG4105NCW Trka-c domain protein FOC92_12100 ENOG4105C19 ABC transporter FOC92_12120 ENOG4105N5T Radical SAM Protein FOC92_12130 ENOG4105DA5 (ABC) transporter FOC92_12155 ENOG4105E8V Alpha Beta Hydrolase Fold protein FOC92_12160 ENOG4108Z0R Transferase FOC92_12165 ENOG4105YVM Phosphoesterase, PA-phosphatase related FOC92_12170 ENOG4105BZF Glycosyl transferase (Group 1 FOC92_12180 ENOG4105EPU Molybdenum cofactor synthesis domain protein FOC92_12190 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC92_12230 ENOG4105BZU Histidine kinase FOC92_12235 ENOG4105BZU Histidine kinase FOC92_12240 ENOG4107S9D Alpha beta hydrolase FOC92_12245 ENOG4107T7U Sulfatase FOC92_12270 ENOG4105D2X ABC transporter substrate-binding protein FOC92_12280 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOC92_12345 ENOG4108V2W Carbonate dehydratase FOC92_12350 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC92_12355 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC92_12390 ENOG41087YS Phage shock protein A FOC92_12420 ENOG4105BZU Histidine kinase FOC92_12425 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC92_12450 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC92_12455 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FOC92_12485 ENOG4107ZTW SNARE associated Golgi FOC92_12500 ENOG4105C19 ABC transporter FOC92_12505 ENOG41086D8 Transcriptional regulator FOC92_12525 ENOG41082BM Transcriptional regulator, arsr family FOC92_12575 ENOG4105C6Z Gluconate FOC92_12600 ENOG41069H0 dihydroorotase EC 3.5.2.3 FOC92_12620 ENOG4105DTQ mandelate racemase muconate lactonizing FOC92_12630 ENOG4108IPT Naphthoate synthase FOC92_12635 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FOC92_12645 ENOG4105E4F Isochorismate synthase FOC92_12650 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC92_12660 ENOG4105VEQ Cold shock protein FOC92_12695 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FOC92_12810 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOC92_12845 ENOG4105KT7 mgtC SapB transporter FOC92_12850 ENOG4107PBV potassium channel FOC92_12865 ENOG4105WG9 Conserved Protein FOC92_12875 ENOG4105CHM Aminotransferase FOC92_12880 ENOG4108ZB6 transcriptional regulator AsnC family FOC92_12885 ENOG4105C5I Dehydrogenase FOC92_12890 ENOG4108MUZ hydrolase FOC92_12900 ENOG4105C87 Aminotransferase class I and II FOC92_12915 ENOG4105Y38 Kinase-associated protein B FOC92_12925 ENOG4107R3E Citrate transporter FOC92_12945 ENOG4105KA0 thioesterase Superfamily protein FOC92_12960 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC92_12980 ENOG41069ER domain protein FOC92_12995 ENOG4105CEP NADH dehydrogenase FOC92_13025 ENOG4105EWC Purine nucleoside phosphorylase FOC92_13040 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOC92_13065 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC92_13070 ENOG4105C4B ABC transporter, permease FOC92_13075 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOC92_13110 ENOG41083MR nifu domain-containing protein FOC92_13125 ENOG4108W5N phosphatidylglycerophosphatase a FOC92_13145 ENOG4105DAX Pfam:DUF2983 FOC92_13155 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC92_13160 ENOG4105D4U had-superfamily hydrolase, subfamily iia FOC92_13175 ENOG4105CBT Fructose-1,6-bisphosphatase FOC92_13190 ENOG4105MMD transcriptional regulator FOC92_13195 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FOC92_13200 ENOG4107TXC Transcriptional regulator FOC92_13205 ENOG41090T1 Membrane FOC92_13230 ENOG4105FAA peptidase M23 FOC92_13235 ENOG4108YTE sporulation protein YunB FOC92_13240 ENOG4105KZD Domain of unknown function (DUF1805) FOC92_13245 ENOG4107R8B 5'-nucleotidase FOC92_13250 ENOG4105DIW FeS assembly protein SUFB FOC92_13255 ENOG4108UNV SUF system FeS assembly protein, NifU family FOC92_13260 ENOG4105C9B Cysteine desulfurase FOC92_13265 ENOG4105JRK feS assembly protein SufD FOC92_13270 ENOG4105C3K feS assembly ATPase SufC FOC92_13275 ENOG4105D01 (LipO)protein FOC92_13280 ENOG4105D01 (LipO)protein FOC92_13285 ENOG4108UMI ABC transporter, permease FOC92_13290 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC92_13315 ENOG41080E8 Transcriptional regulator, Spx MgsR family FOC92_13335 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC92_13360 ENOG4108W8B Beta-lactamase domain protein FOC92_13365 ENOG4105C1G acyl-Coa dehydrogenase FOC92_13370 ENOG4105CHU acetyl-coa acetyltransferase FOC92_13385 ENOG4105DZ1 carboxypeptidase FOC92_13405 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC92_13420 ENOG4108SUT Major Facilitator Superfamily FOC92_13425 ENOG4107R7I amino acid FOC92_13440 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC92_13450 ENOG4107AYK membrAne FOC92_13485 ENOG4107ZTW SNARE associated Golgi FOC92_13495 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC92_13500 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC92_13505 ENOG4105BZU Histidine kinase FOC92_13520 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FOC92_13535 ENOG4105C8Q Methyl-accepting chemotaxis FOC92_13540 ENOG4105VG1 fes assembly suf system protein FOC92_13545 ENOG4105D4Y metalloprotease FOC92_13570 ENOG4107T5V SNARE associated Golgi FOC92_13575 ENOG4107S91 Sodium hydrogen exchanger FOC92_13580 ENOG4105NCW Trka-c domain protein FOC92_13590 ENOG4108RMU ferritin dps family protein FOC92_13605 ENOG4108URH decarboxylase FOC92_13615 ENOG41090A1 ferritin FOC92_13620 ENOG4105DHF Membrane FOC92_13625 ENOG4105D9N nucleoside FOC92_13630 ENOG4105D9N nucleoside FOC92_13645 ENOG4108RYK Nad-dependent epimerase dehydratase FOC92_13660 ENOG4105CV8 reductase FOC92_13665 ENOG4105F27 Major Facilitator FOC92_13670 ENOG4105KVH Transcriptional regulator FOC92_13685 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC92_13690 ENOG4105D4A Cell wall formation (By similarity) FOC92_13700 ENOG4105C8Q Methyl-accepting chemotaxis FOC92_13710 ENOG4105WMR Protein CrcB homolog FOC92_13715 ENOG4105WMR Protein CrcB homolog FOC92_13735 ENOG4105C5H ABC transporter FOC92_13740 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC92_13765 ENOG4108V2W Carbonate dehydratase FOC92_13770 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) FOC92_13785 ENOG4108IPW abc transporter atp-binding protein FOC92_13790 ENOG4105CM4 permease protein FOC92_13805 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC92_13845 ENOG4107RBB ABC transporter, permease FOC92_13850 ENOG4105C19 ABC transporter FOC92_13900 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOC92_13910 ENOG4105XZU Preprotein translocase, subunit SecG FOC92_13915 ENOG41067MG lrgb family FOC92_13965 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC92_13985 ENOG41090VF Stage v sporulation protein ac FOC92_13990 ENOG4105CZ3 stage V sporulation protein ad FOC92_14005 ENOG4108QY0 Membrane FOC92_14015 ENOG4105KRI phosphocarrier protein (HPr FOC92_14025 ENOG4105CHW UPF0052 protein FOC92_14035 ENOG4108Z4K mutator MutT protein FOC92_14045 ENOG4105C3M thioredoxin reductase FOC92_14055 ENOG4108S4C acetyltransferase FOC92_14075 ENOG41086DT Membrane protein of unknown function FOC92_14085 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC92_14090 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOC92_14105 ENOG4107TXC Transcriptional regulator FOC92_14125 ENOG4105DUM transcriptional regulator, lysR family FOC92_14135 ENOG4108WS4 fmn reductase FOC92_14150 ENOG4105BZ1 (ABC) transporter FOC92_14160 ENOG4105CN1 protease FOC92_14165 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOC92_14170 ENOG4105CAK Cell division ATP-binding protein ftsE FOC92_14195 ENOG4108RDQ ABC transporter FOC92_14225 ENOG4105MS2 ribosomal subunit Interface protein FOC92_14230 ENOG4105VEQ Cold shock protein FOC92_14235 ENOG41081UC Inherit from COG: Competence protein FOC92_14250 ENOG4105KVH Transcriptional regulator FOC92_14260 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOC92_14265 ENOG4108KGH TRANSCRIPTIONal FOC92_14270 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC92_14280 ENOG4105ESV Glycosyl transferase, family 4 FOC92_14290 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC92_14310 ENOG4105F8D glycoside hydrolase family 4 FOC92_14315 ENOG4105VCP PTS System FOC92_14320 ENOG4105CK1 PTS System FOC92_14330 ENOG4105VCP PTS System FOC92_14340 ENOG4105VZJ PTS System FOC92_14360 ENOG4105ECB domain protein FOC92_14365 ENOG4107RSM transcriptional regulator FOC92_14400 ENOG4105DAA L-lactate FOC92_14410 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FOC92_14420 ENOG4105E0M Sulfatase FOC92_14445 ENOG4107R8N Glycosyl transferase, family 2 FOC92_14450 ENOG4105C94 Transporter FOC92_14455 ENOG41069ER domain protein FOC92_14480 ENOG4105KBK Zinc finger, swim domain protein FOC92_14485 ENOG4105C0D helicase FOC92_14515 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC92_14525 ENOG4107RBB ABC transporter, permease FOC92_14530 ENOG4105C19 ABC transporter FOC92_14550 ENOG4105CXY transporter FOC92_14565 ENOG4105BZU Histidine kinase FOC92_14570 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC92_14580 ENOG4108KGH TRANSCRIPTIONal FOC92_14585 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOC92_14595 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC92_14600 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOC92_14610 ENOG4105CPK Glycosyl transferase (Group 1 FOC92_14615 ENOG4107EF8 Glycosyl transferase (Group 1 FOC92_14650 ENOG4107U9V N5-(Carboxyethyl)ornithine synthase FOC92_14660 ENOG4108PTS heparinase ii FOC92_14670 ENOG4105D3Q Sugar transferase FOC92_14675 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC92_14680 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FOC92_14685 ENOG4107YJ4 chain length determinant protein FOC92_14690 ENOG4105HTX biosynthesis protein FOC92_14695 ENOG4107YJ4 chain length determinant protein FOC92_14710 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FOC92_14720 ENOG4105FRN stage II sporulation protein FOC92_14735 ENOG4105DY9 regulatoR FOC92_14755 ENOG4106778 Protein of unknown function (DUF1146) FOC92_14760 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC92_14765 ENOG4105C8S subunit m FOC92_14770 ENOG4105D65 subunit l FOC92_14795 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC92_14800 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC92_14810 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC92_14815 ENOG4105BZU Histidine kinase FOC92_14865 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FOC92_14870 ENOG41062M3 atp synthase FOC92_14890 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FOC92_14895 ENOG4108UIC UPF0340 protein FOC92_14900 ENOG4108YZG isomerase FOC92_14915 ENOG4108VGI doxx family FOC92_14920 ENOG4107XC4 flavin reductase domain protein, FMN-binding FOC92_14935 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC92_14945 ENOG4108ZXQ stage ii sporulation protein r FOC92_14950 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC92_14955 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FOC92_14960 ENOG4107104 thymidine kinase FOC92_14970 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOC92_14975 ENOG4105CBT Fructose-1,6-bisphosphatase FOC92_14980 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FOC92_15000 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FOC92_15015 ENOG4105C1G acyl-Coa dehydrogenase FOC92_15020 ENOG4105C1G acyl-Coa dehydrogenase FOC92_15025 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC92_15035 ENOG4105DF6 Fe-S oxidoreductase FOC92_15050 ENOG4105BZU Histidine kinase FOC92_15065 ENOG4105D4Y metalloprotease FOC92_15075 ENOG4105BZU Histidine kinase FOC92_15080 ENOG4105KCT ABC transporter FOC92_15085 ENOG4108M15 ABC transporter FOC92_15090 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FOC92_15100 ENOG4105IIU Aminopeptidase FOC92_15120 ENOG4105JVQ RNA Polymerase FOC92_15130 ENOG410684U Domain of unknown function (DUF1934) FOC92_15150 ENOG4105CYW agmatinase FOC92_15160 ENOG4105DXB Major Facilitator superfamily FOC92_15165 ENOG4107SWG transcriptional regulator MERR family FOC92_15170 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC92_15175 ENOG4105BZ4 penicillin-binding protein FOC92_15180 ENOG4108XFG YwhD family FOC92_15185 ENOG4108Z4T Peptidase M50 FOC92_15190 ENOG41069HH 4-oxalocrotonate tautomerase FOC92_15195 ENOG4105DCI Phosphohydrolase FOC92_15200 ENOG4108MES Periplasmic binding protein FOC92_15205 ENOG4105E0A ABC, transporter FOC92_15210 ENOG4105EHG Permease protein FOC92_15215 ENOG4105DQ5 transport system permease protein FOC92_15225 ENOG4108VCI transcription factor, rsfa family FOC92_15230 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) FOC92_15235 ENOG4108IJ2 phosphate acetyltransferase FOC92_15250 ENOG4108VKI Cell wall hydrolase FOC92_15270 ENOG4107SVH Potassium channel protein FOC92_15280 ENOG410667J hydrolase FOC92_15285 ENOG4105VCH membrane FOC92_15295 ENOG4108TU7 Inherit from COG: (ABC) transporter FOC92_15300 ENOG4105CJ1 ABC, transporter FOC92_15305 ENOG41090WU lipolytic protein G-D-S-L family FOC92_15320 ENOG4105D6E homoserine dehydrogenase FOC92_15345 ENOG4108Y4K DNA-binding transcriptional activator FOC92_15355 ENOG4105WH1 Two component transcriptional regulator luxr family FOC92_15360 ENOG4105BZU Histidine kinase FOC92_15365 ENOG4105DWF phosphomethylpyrimidine kinase FOC92_15370 ENOG4105BZU Histidine kinase FOC92_15375 ENOG4105VCD cytoplasmic protein FOC92_15380 ENOG4105D22 carbon starvation protein FOC92_15385 ENOG4105DY9 regulatoR FOC92_15390 ENOG41079KZ Major Facilitator Superfamily FOC92_15400 ENOG4105CG5 Glycosyl transferase (Group 1 FOC92_15410 ENOG4105EN6 Membrane FOC92_15415 ENOG4106YBV Methyl-accepting chemotaxis FOC92_15425 ENOG4108S4H thioesterase Superfamily protein FOC92_15430 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) FOC92_15445 ENOG4105K64 Glycosyl transferase, family 2 FOC92_15455 ENOG4105EJV Membrane FOC92_15460 ENOG4105CKK Glycosyl transferase, family 2 FOC92_15465 ENOG4105C5H ABC transporter FOC92_15470 ENOG41067SE Tetr family transcriptional regulator FOC92_15480 ENOG4105E0X reductase FOC92_15485 ENOG4106F5Q Membrane FOC92_15500 ENOG4108NEV two component transcriptional regulator, LytTR family FOC92_15505 ENOG4108HRK Histidine kinase FOC92_15510 ENOG4107RGD Major Facilitator superfamily FOC92_15525 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC92_15535 ENOG4105IW1 AmiS UreI transporter FOC92_15540 ENOG4105CMR udp-glucose 4-epimerase FOC92_15545 ENOG4108UT2 hemolysin iii FOC92_15555 ENOG4105C1J atp-dependent rna helicase FOC92_15560 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) FOC92_15580 ENOG4105BZU Histidine kinase FOC92_15595 ENOG4105C0H protease FOC92_15600 ENOG4105Q2H domain protein FOC92_15615 ENOG4105BZU Histidine kinase FOC92_15620 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC92_15645 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FOC92_15650 ENOG4105CDU Replicative dna helicase FOC92_15660 ENOG4105BZR domain protein FOC92_15665 ENOG4108XMW Membrane FOC92_15675 ENOG4108UUM single-stranded DNA-binding protein FOC92_15685 ENOG4105C3G gtp-binding protein FOC92_15690 ENOG4105VDK protein, conserved in bacteria FOC92_15695 ENOG4105D8X mechanosensitive ion channel FOC92_15700 ENOG4108ZDA Sporulation protein YyaC FOC92_15705 ENOG4105FA0 parb-like partition protein FOC92_15710 ENOG4107QJE Chromosome Partitioning Protein FOC92_15730 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FOC92_15740 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC92_15760 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC92_15765 ENOG410848D S4 domain protein YaaA FOC92_15780 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC92_15815 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOC92_15850 ENOG4105ZMH deoxynucleoside kinase FOC92_15860 ENOG4105GTG Isochorismatase FOC92_15865 ENOG4108Z6B deaminase FOC92_15875 ENOG4105C6E dna polymerase iii FOC92_15895 ENOG41067KS pro-sigma K processing FOC92_15930 ENOG4105CXN decarboxylase FOC92_15940 ENOG4105FA2 dna polymerase iii FOC92_15945 ENOG4105MA4 psp1 domain protein FOC92_15955 ENOG41060K3 Methyltransferase FOC92_15965 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOC92_15970 ENOG4105KRN Transcriptional regulator, abrb family FOC92_15975 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FOC92_15980 ENOG4105F8V Hydrolase, tatD family FOC92_15985 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FOC92_15995 ENOG4105XFA sporulation peptidase YabG FOC92_16000 ENOG4105W42 Veg protein FOC92_16015 ENOG4105DFT pur operon repressor FOC92_16020 ENOG4105KME endoribonuclease L-psp FOC92_16040 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FOC92_16050 ENOG4108JA2 transcriptioN-repair coupling factor FOC92_16055 ENOG4108M14 stage v sporulation protein t FOC92_16065 ENOG4108IY2 MazG family FOC92_16070 ENOG41082I2 s4 domain protein FOC92_16075 ENOG4105VYY sporulation protein yabp FOC92_16090 ENOG41060GV RNA binding s1 domain protein FOC92_16110 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FOC92_16115 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC92_16120 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC92_16135 ENOG4105C6T cysteine synthase FOC92_16140 ENOG4105CRQ synthase (Component I) FOC92_16145 ENOG4105DDQ anthranilate synthase FOC92_16150 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FOC92_16155 ENOG4105EEI dihydropteroate synthase FOC92_16160 ENOG4105KRF dihydroneopterin aldolase FOC92_16165 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOC92_16175 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC92_16265 ENOG4108Z0C Uvrb UvrC protein FOC92_16280 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOC92_16290 ENOG4105CTP PilT protein domain protein FOC92_16295 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FOC92_16310 ENOG4105D7W serine acetyltransferase FOC92_16325 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOC92_16330 ENOG4105M0M Tetracycline resistance protein FOC92_16335 ENOG4105QIV RNA polymerase FOC92_16350 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOC92_16375 ENOG4107Y49 methyltransferase FOC92_16390 ENOG4105XPM ribosomal protein FOC92_16520 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC92_16530 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC92_16565 ENOG4108JJB ABC transporter FOC92_16570 ENOG4108JJB ABC transporter FOC92_16575 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC92_16580 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC92_16605 ENOG4105D1F ATP-binding protein FOC92_16620 ENOG4108NMV polysaccharide deacetylase FOC92_16700 ENOG4105C8B TIGR00159 family FOC92_16705 ENOG4107U5W ybbr family FOC92_16720 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FOC92_16745 ENOG4108PSK reductase FOC92_16750 ENOG4108UMI ABC transporter, permease FOC92_16755 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC92_16760 ENOG4105D01 (LipO)protein FOC92_16765 ENOG4105CB2 alcohol dehydrogenase FOC92_16775 ENOG4105IQ5 FAD linked oxidase domain protein FOC92_16790 ENOG4105C2C drug resistance transporter, Bcr CflA FOC92_16805 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC92_16810 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC92_16815 ENOG4105C3U ABC transporter FOC92_16820 ENOG4108JQ7 (ABC) transporter FOC92_16850 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC92_16855 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC92_16875 ENOG4105E0C molybdate abc transporter FOC92_16880 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC92_16885 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FOC92_16895 ENOG4105EGI Transcriptional regulator FOC92_16915 ENOG4105F6E Acyl-transferase FOC92_16935 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC92_16950 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FOC92_16970 ENOG4105C5H ABC transporter FOC92_16980 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FOC92_16990 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC92_16995 ENOG4105C3U ABC transporter FOC92_17000 ENOG4108JQ7 (ABC) transporter FOC92_17005 ENOG410667J hydrolase FOC92_17035 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FOC92_17040 ENOG4105ERH Fumarylacetoacetate hydrolase FOC92_17050 ENOG4105CUB amino acid FOC92_17055 ENOG4108SC4 )-transporter FOC92_17060 ENOG4105CPF Cell wall formation (By similarity) FOC92_17065 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOC92_17090 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FOC92_17095 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC92_17105 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FOC92_17210 ENOG4105K8N protein family UPF0079, ATPase FOC92_17215 ENOG41072GX Peptidase M22 Glycoprotease FOC92_17220 ENOG410801F ribosomal-protein-alanine acetyltransferase FOC92_17225 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC92_17230 ENOG4105C5H ABC transporter FOC92_17245 ENOG4108TYN CAAX amino terminal protease family protein FOC92_17265 ENOG4105C7N Xanthine uracil vitamin C permease FOC92_17275 ENOG4105BZU Histidine kinase FOC92_17300 ENOG4107ZXU DSBA oxidoreductase FOC92_17345 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC92_17385 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) FOC92_17395 ENOG4108SHN Glycosyl transferase, family 2 FOC92_17415 ENOG4105SX7 Transporter FOC92_17440 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOC92_17445 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOC92_17450 ENOG4105C83 adenylosuccinate lyase FOC92_17460 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FOC92_17485 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOC92_17495 ENOG4105C12 Phosphoribosylglycinamide synthetase FOC92_17520 ENOG4105C4R Atp-dependent dna helicase FOC92_17525 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FOC92_17545 ENOG4108W2Y isochorismatase FOC92_17550 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC92_17555 ENOG4108UMI ABC transporter, permease FOC92_17560 ENOG4105D01 (LipO)protein FOC92_17580 ENOG410834F Transcriptional regulator FOC92_17585 ENOG4107I77 yiaA/B two helix domain FOC92_17605 ENOG4105CBD Diacylglycerol kinase FOC92_17610 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC92_17615 ENOG4108JPW Aminotransferase FOC92_17625 ENOG4105C26 Dehydrogenase FOC92_17630 ENOG4105KPY Small multidrug resistance protein FOC92_17660 ENOG4105D9N nucleoside FOC92_17665 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC92_17685 ENOG4108W15 Protein of unknown function (DUF1456) FOC92_17700 ENOG4105DTQ mandelate racemase muconate lactonizing FOC92_17710 ENOG4105DFD Na H antiporter FOC92_17730 ENOG4105D3R alkyl hydroperoxide reductase FOC92_17750 ENOG4105EHG Permease protein FOC92_17755 ENOG4105DQ5 transport system permease protein FOC92_17760 ENOG4108V5C ABC transporter FOC92_17780 ENOG4106UIA FOC92_17785 ENOG4106UIA FOC92_17800 ENOG4105BZU Histidine kinase FOC92_17820 ENOG410756H nucleotidyltransferase FOC92_17825 ENOG4105D2S major facilitator superfamily FOC92_17840 ENOG4105E5Q amino acid AbC transporter FOC92_17845 ENOG4105EAB amino acid AbC transporter FOC92_17855 ENOG4105C8Q Methyl-accepting chemotaxis FOC92_17870 ENOG4105DBV ornithine carbamoyltransferase FOC92_17880 ENOG4105C5B carbamate kinase FOC92_17885 ENOG4108W63 CRP FNR family transcriptional regulator FOC92_17895 ENOG4105DNP FAD linked oxidase domain protein FOC92_17905 ENOG4105CI1 PTS System FOC92_17920 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC92_17935 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FOC92_17955 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC92_17995 ENOG41062JF Transcriptional regulator FOC92_18010 ENOG4105DEU major facilitator superfamily FOC92_18025 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FOC92_18040 ENOG4108N0M stress protein FOC92_18045 ENOG4106FN3 tellurium resistance protein FOC92_18050 ENOG4106FN3 tellurium resistance protein FOC92_18055 ENOG4107TS3 membrane protein, TerC FOC92_18060 ENOG4108TTB tellurium resistance protein FOC92_18080 ENOG4105KJF protein tyrosine phosphatase FOC92_18090 ENOG4107U9T Pfam:Ribonuclease_BN FOC92_18095 ENOG4105C59 p-type ATPase FOC92_18100 ENOG4108IPJ Membrane FOC92_18120 ENOG4107ZTW SNARE associated Golgi FOC92_18135 ENOG410606W general stress protein FOC92_18140 ENOG4105UPD Calcium Proton FOC92_18175 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC92_18180 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC92_18190 ENOG4108JUB Transcriptional regulator FOC92_18200 ENOG4108IQI permease FOC92_18240 ENOG4108A04 Beta-lactamase FOC92_18255 ENOG4105CKK Glycosyl transferase, family 2 FOC92_18260 ENOG4107QQG Dehydrogenase FOC92_18265 ENOG4105C3I Nad-dependent epimerase dehydratase FOC92_18285 ENOG4105F1A Pyruvate formate-lyase FOC92_18290 ENOG4108QBV Monogalactosyldiacylglycerol synthase FOC92_18305 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC92_18310 ENOG4105ECP epimerase FOC92_18340 ENOG41067AE Membrane-bound metal-dependent hydrolase FOC92_18345 ENOG4105CEN a g-specific adenine glycosylase FOC92_18350 ENOG4106BXE FOC92_18370 ENOG4105BZ1 (ABC) transporter FOC92_18375 ENOG4107NBY Membrane FOC92_18380 ENOG4105CBC glutamate synthase FOC92_18390 ENOG4108IUW ABC transporter FOC92_18410 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC92_18415 ENOG4105G5W regulator Fur family FOC92_18535 ENOG4108JQC penicillin-binding protein 1A FOC92_18540 ENOG4108R9S DSBA oxidoreductase FOC92_18550 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOC92_18560 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOC92_18570 ENOG4105CYN Serine protein kinase FOC92_18590 ENOG4105C94 Transporter FOC92_18605 ENOG4105DZ6 Band 7 protein FOC92_18615 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOC92_18620 ENOG4108V9W transcriptional regulatory protein FOC92_18625 ENOG4105D4T Citrate transporter FOC92_18650 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC92_18655 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC92_18660 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOC92_18665 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FOC92_18670 ENOG4105BZ7 extracellular solute-binding protein family 1 FOC92_18675 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOC92_18680 ENOG4108STX response regulator FOC92_18685 ENOG41062D9 Histidine kinase FOC92_18710 ENOG4108MRH transcriptional regulatory protein FOC92_18720 ENOG4105C6K Malic enzyme FOC92_18730 ENOG4108UZ3 Transporter FOC92_18735 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC92_18745 ENOG4105BZU Histidine kinase FOC92_18750 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC92_18755 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC92_18760 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC92_18765 ENOG4108JB9 formate dehydrogenase FOC92_18785 ENOG4105CUB amino acid FOC92_18800 ENOG4105C59 p-type ATPase FOC92_18805 ENOG4105DAP Nicotinate phosphoribosyltransferase FOC92_18840 ENOG41073R8 VanW family FOC92_18845 ENOG4108KGH TRANSCRIPTIONal FOC92_18850 ENOG4105D9N nucleoside FOC92_18855 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOC92_18860 ENOG4105C37 (CBS) domain FOC92_18865 ENOG4108IJ0 Aspartate ammonia-lyase FOC92_18870 ENOG4105DAA L-lactate FOC92_18885 ENOG4105DUX Transporter FOC92_18890 ENOG4108MES Periplasmic binding protein FOC92_18895 ENOG4105DQ5 transport system permease protein FOC92_18900 ENOG4108IHU transport system permease protein FOC92_18905 ENOG4105E0A ABC, transporter FOC92_18910 ENOG4105DMQ Methyltransferase FOC92_18915 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FOC92_18920 ENOG4105EXW epimerase dehydratase FOC92_18930 ENOG4107T89 von Willebrand factor, type A FOC92_18935 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FOC92_18940 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC92_18950 ENOG4105BZU Histidine kinase FOC92_18960 ENOG4105D5Q Arginine ornithine antiporter FOC92_18965 ENOG4107414 GntR family transcriptional regulator FOC92_18970 ENOG4105C5Y PTS System FOC92_18975 ENOG4105CG3 alpha amylase, catalytic region FOC92_18990 ENOG4105E1K spore germination protein FOC92_18995 ENOG4105CRN Aminoglycoside phosphotransferase FOC92_19005 ENOG4105CDA abc transporter atp-binding protein FOC92_19010 ENOG4105CT1 (ABC) transporter FOC92_19015 ENOG4105EAD ABC transporter FOC92_19020 ENOG4105DRP amino acid AbC transporter FOC92_19025 ENOG4108IQI permease FOC92_19040 ENOG4105GFR rna polymerase sigma factor FOC92_19050 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC92_19055 ENOG4105NAE bifunctional deaminase-reductase domain protein FOC92_19060 ENOG4105BZU Histidine kinase FOC92_19065 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC92_19075 ENOG4105CHH sulfate transporter FOC92_19080 ENOG41068KF Universal stress protein FOC92_19090 ENOG4105CXY transporter FOC92_19095 ENOG41067TZ transcriptional regulator, MarR family FOC92_19100 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC92_19105 ENOG4105ETE Transcriptional regulator (LacI family FOC92_19110 ENOG4108RVA ribokinase FOC92_19120 ENOG4105C2J ABC transporter FOC92_19125 ENOG4105CNN ABC, transporter FOC92_19130 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOC92_19135 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC92_19175 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) FOC92_19205 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC92_19210 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC92_19215 ENOG41069ER domain protein FOC92_19220 ENOG4105VZ8 Transcriptional regulator FOC92_19225 ENOG4107D63 FOC92_19240 ENOG4105DUX Transporter FOC92_19260 ENOG4105C85 amino acid FOC92_19265 ENOG4105C7N Xanthine uracil vitamin C permease FOC92_19280 ENOG4105MA6 gCN5-related N-acetyltransferase FOC92_19300 ENOG4105CCU oxidase (Subunit III) FOC92_19305 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC92_19310 ENOG4105E2S oxidase) subunit II FOC92_19335 ENOG4105E1V na solute symporter FOC92_19350 ENOG4108NHD germination protein FOC92_19360 ENOG4105CE1 Ferrous iron transport protein b FOC92_19365 ENOG4105CE1 Ferrous iron transport protein b FOC92_19370 ENOG4105CE1 Ferrous iron transport protein b FOC92_19375 ENOG4105CVA phosphate FOC92_19380 ENOG4105C8U phosphate abc transporter FOC92_19505 ENOG41080XQ Signal transduction protein with cbs domains FOC92_19525 ENOG4105ETU transcriptional activator (TenA FOC92_19535 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC92_19545 ENOG4108VEU Thiamine monophosphate synthase FOC92_19550 ENOG41080HI glycine oxidase FOC92_19565 ENOG4105D06 uba thif-type nad fad binding protein FOC92_19570 ENOG4105DWF phosphomethylpyrimidine kinase FOC92_19620 ENOG4108INS Transcriptional regulator FOC92_19645 ENOG4105C19 ABC transporter FOC92_19655 ENOG4105C7N Xanthine uracil vitamin C permease FOC92_19665 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC92_19680 ENOG4105K63 Thioredoxin FOC92_19700 ENOG4108B31 Spore germination protein FOC92_19720 ENOG4107Y03 Nitroreductase FOC92_19725 ENOG4105ED1 spovr family FOC92_19735 ENOG4108TCS Glutamyl endopeptidase FOC92_19740 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FOC92_19745 ENOG4105XTG Pfam:DUF156 FOC92_19750 ENOG4105VFE sira family FOC92_19755 ENOG4107TPS domain protein FOC92_19760 ENOG4105VFE sira family FOC92_19765 ENOG4105VFE sira family FOC92_19775 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FOC92_19780 ENOG41087NI Sulfite exporter TauE/SafE FOC92_19790 ENOG4108KGH TRANSCRIPTIONal FOC92_19815 ENOG4105EMD TRANSCRIPTIONal FOC92_19820 ENOG4105VCP PTS System FOC92_19825 ENOG4105VZJ PTS System FOC92_19850 ENOG41069ER domain protein FOC92_19855 ENOG4107RBB ABC transporter, permease FOC92_19860 ENOG4105C19 ABC transporter FOC92_19890 ENOG4105WEF catalase FOC92_19925 ENOG4107T5V SNARE associated Golgi FOC92_19960 ENOG4105CUB amino acid FOC92_19965 ENOG4107RWR Sodium hydrogen exchanger FOC92_19975 ENOG4106KNT transcriptional regulator FOC92_20015 ENOG4108YXU transcriptional regulator AsnC family FOC92_20020 ENOG4105CH7 arginosuccinase FOC92_20025 ENOG4105UBK short-chain dehydrogenase reductase FOC92_20070 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC92_20075 ENOG4105E5W Transporter FOC92_20090 ENOG4107RKG DJ-1/PfpI family FOC92_20095 ENOG4105CH6 catalase FOC92_20105 ENOG4105D5Q Arginine ornithine antiporter FOC92_20110 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOC92_20120 ENOG4105C26 Dehydrogenase FOC92_20125 ENOG4105BZ1 (ABC) transporter FOC92_20130 ENOG4105BZ1 (ABC) transporter FOC92_20140 ENOG4105DRP amino acid AbC transporter FOC92_20145 ENOG4105CDA abc transporter atp-binding protein FOC92_20160 ENOG410839P FOC92_20170 ENOG4108UH6 UPF0754 membrane protein FOC92_20185 ENOG4105BZU Histidine kinase FOC92_20190 ENOG4105WH1 Two component transcriptional regulator luxr family FOC92_20240 ENOG4107FQX Alpha-acetolactate decarboxylase FOC92_20250 ENOG4108VX5 3-methyladenine DNA glycosylase FOC92_20265 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC92_20270 ENOG4105D4P Coproporphyrinogen iii oxidase FOC92_20275 ENOG4105CEY Amp-dependent synthetase and ligase FOC92_20290 ENOG4105CHH sulfate transporter FOC92_20315 ENOG4105CGU Enoyl-CoA hydratase FOC92_20335 ENOG4105DER m42 family FOC92_20380 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC92_20390 ENOG4108JQ7 (ABC) transporter FOC92_20405 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein FOC92_20465 ENOG4108IBT Inherit from COG: transposase FOC92_20520 ENOG4105CSH Transporter FOC92_20530 ENOG4108MRH transcriptional regulatory protein FOC92_20550 ENOG4107SCJ type I restriction enzyme EcoKI subunit R FOC92_20595 ENOG4105CDU Replicative dna helicase FOC92_20620 ENOG4108Z86 Glutamine amidotransferase FOC92_20640 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC92_20660 ENOG4105D9U N-acetyltransferase FOC92_20715 ENOG4105F6J Alpha beta hydrolase fold FOC92_20765 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC92_20780 ENOG4108NIW Leucine export protein LeuE FOC92_20785 ENOG4105CMT Dihydroxyacetone kinase FOC92_20795 ENOG4105CMT Dihydroxyacetone kinase FOC92_20890 ENOG4105WN5 stage II sporulation protein FOC92_20900 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC92_20910 ENOG4108MJI response regulator FOC92_20915 ENOG4105BZU Histidine kinase FOC92_20920 ENOG4105BZU Histidine kinase FOC92_20960 ENOG4105D7V transposase FOC92_20970 ENOG4107QHE Choloylglycine hydrolase FOC92_20990 ENOG4107VRP DNA repair exonuclease FOC92_20995 ENOG4106D4I domain protein FOC92_21005 ENOG4105ED2 Beta-lactamase FOC92_21040 ENOG4108MUZ hydrolase FOC92_21060 ENOG4105F0F Oxalate decarboxylase FOC92_21070 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC92_21085 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOC92_21105 ENOG4105DU6 RNA polymerase FOC92_21115 ENOG4105CNI cell division protein FtsW FOC92_21120 ENOG4105EEM helicase FOC92_21125 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC92_21150 ENOG4105K59 histidine triad (HIT) protein FOC92_21185 ENOG410905X membrane-flanked domain protein FOC92_21190 ENOG4105CKV Membrane FOC92_21230 ENOG410905X membrane-flanked domain protein FOC92_21240 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FOC92_21245 ENOG4105BZ4 penicillin-binding protein FOC92_21255 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC92_21260 ENOG4105C1Q protoporphyrinogen oxidase FOC92_21285 ENOG4105NA0 Transcriptional regulator FOC92_21300 ENOG4105ECB domain protein FOC92_21300 ENOG4105ECB domain protein FOC92_21330 ENOG4106AXD FOC92_21335 ENOG4108RQ5 Beta-lactamase domain-containing protein FOC92_21340 ENOG4105DF9 Lipoate-protein, ligase FOC92_21350 ENOG4105CEY Amp-dependent synthetase and ligase FOC92_21360 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FOC92_21365 ENOG4108I5D sulfate abc transporter FOC92_21370 ENOG4105ECW sulfate abc transporter FOC92_21375 ENOG4108IJ6 ABC transporter FOC92_21390 ENOG4107RN3 metallophosphoesterase FOC92_21395 ENOG4107TVP HD domain protein FOC92_21405 ENOG4108AEY RNA polymerase sigma factor FOC92_21410 ENOG41086D8 Transcriptional regulator FOC92_21425 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC92_21445 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FOC92_21450 ENOG4105C8Q Methyl-accepting chemotaxis FOC92_21455 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) FOC92_21465 ENOG4107QP3 malate synthase g FOC92_21565 ENOG4105ERH Fumarylacetoacetate hydrolase FOC92_21575 ENOG4105C8Y Acetylornithine aminotransferase FOC92_21590 ENOG4105CAQ asparagine synthetase FOC92_21595 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC92_21600 ENOG4105CH6 catalase FOC92_21605 ENOG4105BZU Histidine kinase FOC92_21625 ENOG4105QNR S1 RNA binding domain protein FOC92_21630 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC92_21640 ENOG4107AYK membrAne FOC92_21645 ENOG41073B9 FOC92_21655 ENOG4108KP7 hydrolase FOC92_21665 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC92_21690 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC92_21695 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC92_21710 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC92_21725 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC92_21730 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC92_21740 ENOG4108JQ7 (ABC) transporter FOC92_21745 ENOG4105UQX Mate efflux family protein FOC92_21765 ENOG4108ZCF integral membrane protein FOC92_21775 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC92_21785 ENOG4105DPN Oligoendopeptidase f FOC92_21800 ENOG4108Z18 K06886 hemoglobin FOC92_21805 ENOG4105MIX Adenylate cyclase FOC92_21820 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FOC92_21825 ENOG4105EMS pseudouridine synthase FOC92_21845 ENOG4105K64 Glycosyl transferase, family 2 FOC92_21865 ENOG4107TVC Glycosyl transferase, family 2 FOC92_21885 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOC92_21890 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC92_21900 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOC92_21975 ENOG4105CK7 Sodium proline symporter FOC92_21985 ENOG4105DDQ anthranilate synthase FOC92_21995 ENOG4105DK0 Indole-3-glycerol phosphate synthase FOC92_22065 ENOG41089UC methyltransferase, type 11 FOC92_22085 ENOG4105C7S Dehydrogenase FOC92_22090 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FOC92_22125 ENOG4108IUX (ABC) transporter FOC92_22130 ENOG4105RHA ABC transporter, permease FOC92_22155 ENOG4105DZ1 carboxypeptidase FOC92_22160 ENOG4105VFR signal peptidase FOC92_22195 ENOG4105C26 Dehydrogenase FOC92_22200 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC92_22205 ENOG4105F38 ABC transporter, permease FOC92_22210 ENOG4105D38 putrescine abc transporter FOC92_22215 ENOG4108HM4 ABC transporter FOC92_22225 ENOG4105EYF MMPL domain protein FOC92_22235 ENOG4108YBP pseudouridine synthase FOC92_22245 ENOG4105K4I Scp-like extracellular FOC92_22250 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOC92_22255 ENOG4105CQB FAD linked oxidase domain protein FOC92_22270 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC92_22275 ENOG4105BZU Histidine kinase FOC92_22280 ENOG4105JXH GntR family transcriptional regulator FOC92_22300 ENOG4106A3R peptidase FOC92_22310 ENOG4108QTI )-transporter FOC92_22315 ENOG4107TS3 membrane protein, TerC FOC92_22320 ENOG4105CZN Potassium uptake protein FOC92_22325 ENOG410681C small acid-soluble spore protein FOC92_22330 ENOG4108Z7G MaoC domain protein dehydratase FOC92_22350 ENOG4105CHR reductase FOC92_22380 ENOG4105C4Y ABC transporter FOC92_22385 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC92_22390 ENOG4107RCV ABC transporter, permease FOC92_22410 ENOG4105E98 transcriptional regulator DeoR family FOC92_22420 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FOC92_22430 ENOG4105PXI polysaccharide deacetylase FOC92_22440 ENOG4105BZU Histidine kinase FOC92_22445 ENOG41090MY MarR family Transcriptional regulator FOC92_22455 ENOG4106DF1 FOC92_22460 ENOG4105BZU Histidine kinase FOC92_22465 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FOC92_22470 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FOC92_22475 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOC92_22510 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOC92_22515 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC92_22520 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC92_22525 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC92_22530 ENOG4105CZV ABC transporter FOC92_22540 ENOG4105CJ1 ABC, transporter FOC92_22580 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC92_22585 ENOG4105EA8 2-Nitropropane dioxygenase FOC92_22590 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC92_22600 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC92_22625 ENOG4105NQC Flavodoxin FOC92_22695 ENOG4105CZN Potassium uptake protein FOC92_22700 ENOG41063Y9 FOC92_22705 ENOG4105KBJ sporulation protein ytfj FOC92_22725 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC92_22730 ENOG4105C7K acetolactate synthase FOC92_22735 ENOG4108ZP8 Acetolactate synthase small subunit FOC92_22740 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC92_22755 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FOC92_22770 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FOC92_22775 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FOC92_22780 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FOC92_22785 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FOC92_22790 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FOC92_22795 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FOC92_22810 ENOG4107RVV histidinol phosphate phosphatase, hisj family FOC92_22825 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC92_22830 ENOG4105E0M Sulfatase FOC92_22840 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOC92_22855 ENOG4107S4M Sulfate adenylate transferase FOC92_22860 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FOC92_22865 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FOC92_22875 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC92_22880 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC92_22885 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC92_22890 ENOG4105C8J )-transporter FOC92_22920 ENOG4105DFD Na H antiporter FOC92_22940 ENOG4105ENE Histidine kinase FOC92_22945 ENOG4105WH1 Two component transcriptional regulator luxr family FOC92_22965 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC92_22990 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FOC92_23010 ENOG4105CJ3 phosphate transporter FOC92_23015 ENOG4107GRR phosphate transport regulator FOC92_23020 ENOG4105BZ4 penicillin-binding protein FOC92_23035 ENOG4105BZU Histidine kinase FOC92_23040 ENOG4105I3N Conserved Protein FOC92_23055 ENOG4105BZU Histidine kinase FOC92_23085 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC92_23090 ENOG4105DZ1 carboxypeptidase FOC92_23095 ENOG4108JIC nucleoside recognition domain protein FOC92_23105 ENOG4105FE9 pseudouridine synthase FOC92_23110 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC92_23115 ENOG4107TWT Cytochrome c biogenesis protein FOC92_23120 ENOG4105CRE cytochrome C FOC92_23125 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC92_23130 ENOG4105BZU Histidine kinase FOC92_23135 ENOG4108WBT adenosyltransferase FOC92_23150 ENOG4108SAX Membrane FOC92_23165 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC92_23170 ENOG4105I7S Abortive infection protein FOC92_23180 ENOG4107RGJ metallophosphoesterase FOC92_23185 ENOG4108XDN Transcriptional regulator FOC92_23190 ENOG4108S6Z Negative regulator of genetic competence FOC92_23215 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FOC92_23220 ENOG4107RB3 L-asparaginase FOC92_23240 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FOC92_23255 ENOG4105S2F FOC92_23260 ENOG41065D1 FOC92_23290 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FOC92_23305 ENOG4105XXQ heptaprenyl diphosphate synthase component I FOC92_23315 ENOG4105EAH synthase FOC92_23320 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FOC92_23325 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FOC92_23340 ENOG41068YB TPR repeat-containing protein FOC92_23355 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FOC92_23360 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOC92_23395 ENOG4108JYZ YitT family FOC92_23400 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FOC92_23415 ENOG4105FJR Lmbe family FOC92_23420 ENOG4105CPK Glycosyl transferase (Group 1 FOC92_23440 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FOC92_23455 ENOG4105DVT helicase FOC92_23460 ENOG4105YAC FOC92_23480 ENOG4105CSM endonuclease III FOC92_23490 ENOG4105BZ4 penicillin-binding protein FOC92_23545 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOC92_23555 ENOG4105DVT helicase FOC92_23560 ENOG4105CTD carboxy-peptidase FOC92_23570 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC92_23580 ENOG4105C2W permease FOC92_23585 ENOG4105DHF Membrane FOC92_23595 ENOG410890F Dynamin family FOC92_23605 ENOG4108W0I acetyltransferase FOC92_23615 ENOG4105KHC sulfurtransferase FOC92_23670 ENOG4105HTX biosynthesis protein FOC92_23700 ENOG4105CPK Glycosyl transferase (Group 1 FOC92_23715 ENOG4108SZE gCN5-related N-acetyltransferase FOC92_23735 ENOG41081VK Ribonuclease FOC92_23800 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC92_23810 ENOG4107RWR Sodium hydrogen exchanger FOC92_23815 ENOG4105CN5 Metallo-Beta-Lactamase FOC92_23820 ENOG4108Z5V transcriptional regulator, merr family FOC92_23830 ENOG4105H67 Protein of unknown function (DUF421) FOC92_23835 ENOG41080C8 DUF218 domain FOC92_23875 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC92_23885 ENOG4107R0U MotA TolQ exbB proton channel FOC92_23890 ENOG4105ER2 Ompa motb domain protein FOC92_23895 ENOG4107YTP response regulator receiver protein FOC92_23900 ENOG4105CBS Chea signal transduction histidine kinase FOC92_23905 ENOG4105DD5 Flagellar motor switch protein FOC92_23920 ENOG4105BZU Histidine kinase FOC92_23940 ENOG4105E1Q flagellar hook-associated protein FOC92_23945 ENOG4105DTJ flagellar hook-associated protein FOC92_23950 ENOG4105DTS flagellar hook-associated FOC92_23965 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOC92_23970 ENOG4108ZC9 flagellar basal-body rod protein flgc FOC92_23980 ENOG4107U2N Flagellar M-ring protein FOC92_23985 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC92_24015 ENOG4105BZE flagellar hook protein, FlgE FOC92_24030 ENOG4107R88 Chemotaxis protein (CheV) FOC92_24040 ENOG4105I03 Flagellin FOC92_24045 ENOG4105I03 Flagellin FOC92_24050 ENOG4105E4C Lytic transglycosylase catalytic FOC92_24060 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC92_24065 ENOG4105DD5 Flagellar motor switch protein FOC92_24075 ENOG4105CN7 Flagellar biosynthetic protein FliP FOC92_24080 ENOG4105VS8 Flagellar biosynthetic protein fliq FOC92_24090 ENOG4105D00 flagellar biosynthetic protein flhB FOC92_24095 ENOG4105D7B Flagellar biosynthesis protein flha FOC92_24100 ENOG4105FZW flagellar biosynthesis regulator FlhF FOC92_24105 ENOG4105KTQ flagellar basal-body rod protein FOC92_24110 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC92_24145 ENOG4105KAC Antibiotic biosynthesis monooxygenase FOC92_24180 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC92_24185 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FOC92_24220 ENOG4105CVJ phosphoglycerate mutase FOC92_24230 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FOC92_24250 ENOG4105CAQ asparagine synthetase FOC92_24270 ENOG4105PGM cation diffusion facilitator family transporter FOC92_24280 ENOG4105DRR Transcriptional regulator, GntR family FOC92_24285 ENOG4108UZ3 Transporter FOC92_24295 ENOG4105CKI cobalamin synthesis protein FOC92_24300 ENOG4108PJD permease FOC92_24315 ENOG4105DFD Na H antiporter FOC92_24320 ENOG4105VUF Transcriptional regulator FOC92_24330 ENOG4105C9Q fumarate hydratase class II FOC92_24350 ENOG4107QJQ Mate efflux family protein FOC92_24355 ENOG4105EC3 peptidase S51, dipeptidase E FOC92_24380 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC92_24565 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC92_24605 ENOG4105K63 Thioredoxin FOC92_24630 ENOG4105C2M dna polymerase I FOC92_24690 ENOG4106BRA Membrane FOC92_24725 ENOG4105CJ1 ABC, transporter FOC92_24750 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC92_24760 ENOG4108IJ0 Aspartate ammonia-lyase FOC92_24765 ENOG4105C6K Malic enzyme FOC92_24815 ENOG4105FVX FOC92_24830 ENOG4105CSR polyphosphate kinase 2 FOC92_24835 ENOG4105U3E Transcriptional regulator FOC92_24845 ENOG4105DXI Major Facilitator superfamily FOC92_24855 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC92_24860 ENOG4105EU0 Major facilitator Superfamily FOC92_24865 ENOG4105C6T cysteine synthase FOC92_24885 ENOG4105C8J )-transporter FOC92_24890 ENOG4105X5K response regulator receiver protein FOC92_24895 ENOG4105H67 Protein of unknown function (DUF421) FOC92_24915 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC92_24920 ENOG4105CHR reductase FOC92_24925 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC92_24930 ENOG4105C7K acetolactate synthase FOC92_24940 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC92_24945 ENOG4105C01 Dihydroxy-acid dehydratase FOC92_24950 ENOG4105C7B Threonine dehydratase FOC92_24975 ENOG4105C6X Major Facilitator FOC92_24980 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FOC92_24990 ENOG4105DY9 regulatoR FOC92_24995 ENOG4105CYC Transferase FOC92_25000 ENOG4105K5X acetyltransferase FOC92_25020 ENOG41068WN FOC92_25040 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOC92_25055 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOC92_25060 ENOG4105C0X amino acid FOC92_25085 ENOG4105K8R UPF0145 protein FOC92_25100 ENOG4107RHR regulatoR FOC92_25110 ENOG4105D9N nucleoside FOC92_25115 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FOC92_25135 ENOG4108IBT Inherit from COG: transposase FOC92_25165 ENOG4107RAQ aminopeptidase FOC92_25175 ENOG4107R16 Multicopper oxidase FOC92_25215 ENOG4108T5E Copper resistance protein FOC92_25220 ENOG4105KTB nuclear export factor GLE1 FOC92_25225 ENOG4107RT3 EamA-like transporter family FOC92_25230 ENOG4105GZI Transcriptional regulator FOC92_25235 ENOG4108Z40 Transcriptional regulator FOC92_25240 ENOG4107ZXU DSBA oxidoreductase FOC92_25245 ENOG4108TVJ Nitroreductase FOC92_25250 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC92_25255 ENOG4106F5Q Membrane FOC92_25260 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC92_25270 ENOG4105CKI cobalamin synthesis protein FOC92_25280 ENOG4105C0Z ABC transporter FOC92_25285 ENOG4108IV0 ABC, transporter FOC92_25290 ENOG4105C32 Amino acid ABC transporter (Permease) FOC92_25300 ENOG4105SKE transcriptional Regulator LysR family FOC92_25320 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC92_25325 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC92_25330 ENOG4108JJ9 ABC, transporter FOC92_25335 ENOG4108JJ8 (ABC) transporter FOC92_25345 ENOG4105K64 Glycosyl transferase, family 2 FOC92_25355 ENOG4108UT6 Transferase hexapeptide repeat containing protein FOC92_25410 ENOG4105BZ1 (ABC) transporter FOC92_25415 ENOG4105EFI regulatoR FOC92_25420 ENOG4105BZU Histidine kinase FOC92_25430 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FOC92_25455 ENOG4105D6E homoserine dehydrogenase FOC92_25465 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FOC92_25480 ENOG4108KGH TRANSCRIPTIONal FOC92_25490 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC92_25495 ENOG4105BZU Histidine kinase FOC92_25510 ENOG4105KT7 mgtC SapB transporter FOC92_25525 ENOG4105DUU IucA IucC family protein FOC92_25530 ENOG4105CEY Amp-dependent synthetase and ligase FOC92_25545 ENOG4108WBH protein TIM barrel FOC92_25550 ENOG4105YWU small acid-soluble spore protein FOC92_25560 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FOC92_25565 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC92_25615 ENOG4105KRN Transcriptional regulator, abrb family FOC92_25625 ENOG4105YVS arsR family transcriptional regulator FOC92_25630 ENOG4105CPC Aldo Keto reductase FOC92_25635 ENOG4107XZQ multidrug resistance protein FOC92_25660 ENOG4105C8Q Methyl-accepting chemotaxis FOC92_25675 ENOG4108K88 Membrane FOC92_25680 ENOG4108WPJ Ferritin-like domain FOC92_25695 ENOG4105DEN Luciferase family FOC92_25710 ENOG4105VMI -acetyltransferase FOC92_25715 ENOG4107QM2 Aldo Keto reductase FOC92_25720 ENOG4105CKI cobalamin synthesis protein FOC92_25730 ENOG4105DSE periplasmic solute binding protein FOC92_25740 ENOG4105K4T epimerase FOC92_25750 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC92_25795 ENOG4107T5V SNARE associated Golgi FOC92_25810 ENOG4108PJD permease FOC92_25820 ENOG4108S4H thioesterase Superfamily protein FOC92_25830 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC92_25850 ENOG4105SXS Protein of unknown function (DUF456) FOC92_25855 ENOG4105C37 (CBS) domain FOC92_25875 ENOG4108Z7R Chaperone CsaA FOC92_25895 ENOG4108ZRV stage ii sporulation protein p FOC92_25905 ENOG4108VXD carboxy-peptidase FOC92_25935 ENOG4108ZRV stage ii sporulation protein p FOC92_25945 ENOG4108X4Q Hydrolase FOC92_25960 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC92_25975 ENOG41087PP glycosyltransferase MGT family FOC92_25980 ENOG4108JYZ YitT family FOC92_25985 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC92_26015 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC92_26050 ENOG4108MGT Required for secretion of EsxA and EsxB FOC92_26135 ENOG4105D7V transposase FOC92_26140 ENOG4105KBJ sporulation protein ytfj FOC92_26165 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC92_26185 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FOC92_26195 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FOC92_26200 ENOG4105EMN RNA polymerase sigma factor FOC92_26215 ENOG4105CNW domain protein FOC92_26225 ENOG4108V06 Glutathione peroxidase FOC92_26240 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC92_26250 ENOG4108IUE nitrate reductase beta subunit FOC92_26255 ENOG4105R3A Nitrate reductase FOC92_26265 ENOG4107V6Q Cyclic nucleotide-binding domain FOC92_26270 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC92_26275 ENOG4105D06 uba thif-type nad fad binding protein FOC92_26280 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC92_26285 ENOG4108ZAF Molybdopterin FOC92_26290 ENOG41067WU Molybdopterin converting factor (Subunit 1) FOC92_26315 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC92_26320 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC92_26325 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC92_26330 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOC92_26335 ENOG4108IFG nitrite reductase, (NAD(P)H) FOC92_26340 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FOC92_26375 ENOG4105MCT stage V sporulation protein S FOC92_26415 ENOG4105C5H ABC transporter FOC92_26430 ENOG4108UUM single-stranded DNA-binding protein FOC92_26455 ENOG4107YX5 Pfam:DUF548 FOC92_26460 ENOG4105C75 arginyL-tRNA synthetase FOC92_26485 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FOC92_26510 ENOG4105C5S asparaginyl-tRNA synthetase FOC92_26515 ENOG4105C8J )-transporter FOC92_26535 ENOG4107XGZ Hydrolase FOC92_26540 ENOG4105CY2 Citrate transporter FOC92_26560 ENOG4105KD7 acetyltransferase FOC92_26570 ENOG4105VMP Transcriptional regulator FOC92_26575 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FOC92_26600 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FOC92_26615 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FOC92_26620 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FOC92_26630 ENOG4107RVG penicillin-binding protein FOC92_26635 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC92_26640 ENOG4105E9Q Acyl-transferase FOC92_26645 ENOG4108UT2 hemolysin iii FOC92_26655 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOC92_26665 ENOG4108RCR degv family FOC92_26675 ENOG4108KF3 Electron transport protein SCO1 SenC FOC92_26680 ENOG4107Y70 Heat shock protein FOC92_26685 ENOG4105CAQ asparagine synthetase FOC92_26705 ENOG4108MES Periplasmic binding protein FOC92_26710 ENOG4105F0I Aminotransferase FOC92_26745 ENOG4105D8X mechanosensitive ion channel FOC92_26750 ENOG4105BZU Histidine kinase FOC92_26755 ENOG4105WH1 Two component transcriptional regulator luxr family FOC92_26760 ENOG4106KNT transcriptional regulator FOC92_26765 ENOG4107ZY0 Phenazine biosynthesis-like protein FOC92_26785 ENOG4105CMG Carbohydrate kinase FOC92_26790 ENOG4105C6Z Gluconate FOC92_26800 ENOG4108YV3 Protein of unknown function (DUF2711) FOC92_26830 ENOG4108IJ8 ABC transporter FOC92_26835 ENOG4105E90 ABC transporter FOC92_26870 ENOG4105C37 (CBS) domain FOC92_26895 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC92_26910 ENOG4107S4Y M20 DapE family protein YgeY FOC92_26915 ENOG4108TSC N-acetyltransferase FOC92_26920 ENOG4108JUB Transcriptional regulator FOC92_26925 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FOC92_26970 ENOG410841Q phosphoesterase PA-phosphatase related protein FOC92_26980 ENOG4105SZ6 Thioredoxin FOC92_27015 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC92_27080 ENOG4105BZ4 penicillin-binding protein FOC92_27090 ENOG4105CZM Major Facilitator FOC92_27095 ENOG4105W8X HesB YadR YfhF-family protein FOC92_27105 ENOG4105DXD 2-methylcitrate dehydratase FOC92_27110 ENOG4105CR4 methylisocitrate lyase FOC92_27115 ENOG4105C1G acyl-Coa dehydrogenase FOC92_27120 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC92_27130 ENOG4105N14 lysine exporter protein LysE YggA FOC92_27135 ENOG4105E39 Enoyl-CoA hydratase FOC92_27150 ENOG4107RFY SbcCD D subunit FOC92_27155 ENOG4105EYH Exonuclease FOC92_27175 ENOG4105FCD Major Facilitator FOC92_27180 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FOC92_27185 ENOG4105E4F Isochorismate synthase FOC92_27190 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FOC92_27195 ENOG4105WQI isochorismatase FOC92_27200 ENOG4105CEY Amp-dependent synthetase and ligase FOC92_27205 ENOG4105WQT MbtH domain protein FOC92_27210 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC92_27225 ENOG4105K70 DNA-binding protein FOC92_27245 ENOG4105BZG amino acid carrier protein FOC92_27265 ENOG4105FE9 pseudouridine synthase FOC92_27270 ENOG4105C22 threonyL-tRNA synthetase FOC92_27275 ENOG4105C19 ABC transporter FOC92_27315 ENOG41081I9 integral membrane protein FOC92_27340 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC92_27350 ENOG4105EYF MMPL domain protein FOC92_27380 ENOG4105WCN acetyltransferase FOC92_27405 ENOG4105C1Q protoporphyrinogen oxidase FOC92_27415 ENOG41068WN FOC92_27445 ENOG4107V2S Transcriptional regulator FOC92_27450 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC92_27470 ENOG4105DND Transcriptional regulator FOC92_27475 ENOG4108RPX mosc domain containing protein FOC92_27490 ENOG4105BZ1 (ABC) transporter FOC92_27495 ENOG4105BZ1 (ABC) transporter FOC92_27520 ENOG4108JCI Transcriptional regulator FOC92_27555 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) FOC92_27585 ENOG4105F32 YngK protein FOC92_27610 ENOG4105RD7 BadF BadG BcrA BcrD FOC92_27615 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FOC92_27620 ENOG4107STF Involved in phosphonate degradation (By similarity) FOC92_27630 ENOG4108INS Transcriptional regulator FOC92_27645 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC92_27655 ENOG4105C1J atp-dependent rna helicase FOC92_27665 ENOG4108RZE Tetr family transcriptional regulator FOC92_27690 ENOG41088CC tellurite resistance protein tehB FOC92_27700 ENOG4108I0C methyltransferase FOC92_27705 ENOG4107RA9 decarboxylase FOC92_27710 ENOG4105K56 Transcriptional regulator FOC92_27715 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FOC92_27740 ENOG4105CIN aminoacyl-histidine dipeptidase FOC92_27765 ENOG4105KRN Transcriptional regulator, abrb family FOC92_27775 ENOG4105EJ9 Membrane FOC92_27780 ENOG4105EQK -acetyltransferase FOC92_27820 ENOG4105W8Z 4'-phosphopantetheinyl transferase FOC92_27830 ENOG4105CHR reductase FOC92_27895 ENOG4108IMY Transcriptional regulator FOC92_27915 ENOG4108RZE Tetr family transcriptional regulator FOC92_27920 ENOG4105CAQ asparagine synthetase FOC92_27925 ENOG4108XG2 Histidine kinase FOC92_27935 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC92_27960 ENOG4105EJQ L-serine dehydratase FOC92_27965 ENOG4105C44 Serine transporter FOC92_27985 ENOG4105F6S Spore photoproduct lyase FOC92_27995 ENOG4105CVK Glutamate decarboxylase FOC92_28005 ENOG4107QHE Choloylglycine hydrolase FOC92_28030 ENOG4107RVG penicillin-binding protein FOC92_28045 ENOG4107RF6 penicillin-binding protein FOC92_28050 ENOG4107RF6 penicillin-binding protein FOC92_28060 ENOG4105DIN metallophosphoesterase FOC92_28070 ENOG4105CJ1 ABC, transporter FOC92_28080 ENOG4107Z3H Transcriptional regulator, TetR family FOC92_28095 ENOG4105C1G acyl-Coa dehydrogenase FOC92_28100 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC92_28105 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FOC92_28110 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC92_28115 ENOG4105E39 Enoyl-CoA hydratase FOC92_28120 ENOG4107QX3 carboxylase FOC92_28125 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC92_28155 ENOG4105DBI uridine monophosphokinase FOC92_28175 ENOG4105DZ1 carboxypeptidase FOC92_28190 ENOG4105T9C HD domain FOC92_28200 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC92_28220 ENOG41075H3 AraC family transcriptional regulator FOC92_28250 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC92_28275 ENOG4107Y80 Major Facilitator superfamily FOC92_28285 ENOG4105KVH Transcriptional regulator FOC92_28290 ENOG41089UC methyltransferase, type 11 FOC92_28335 ENOG4105EFA 4-hydroxyphenylacetate FOC92_28350 ENOG4105CPQ Dehydrogenase FOC92_28360 ENOG410900G Protein of unknown function (DUF421) FOC92_28365 ENOG4108V4B ThiJ pfpI FOC92_28375 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FOC92_28445 ENOG4105D6E homoserine dehydrogenase FOC92_28455 ENOG4105CPF Cell wall formation (By similarity) FOC92_28460 ENOG4105ETU transcriptional activator (TenA FOC92_28485 ENOG4105VTR Integrase FOC92_28510 ENOG4108IMY Transcriptional regulator FOC92_28540 ENOG4108NF7 phage-type endonuclease FOC92_28550 ENOG4108PNI recT protein FOC92_28575 ENOG4108SXZ UPF0302 protein FOC92_28605 ENOG4105KNA -acetyltransferase FOC92_28700 ENOG4108TFU terminase (Small subunit) FOC92_28795 ENOG4105XSJ toxin secretion phage lysis holin FOC92_28925 ENOG410667J hydrolase FOC92_28930 ENOG4105BZU Histidine kinase FOC92_28935 ENOG4107RF6 penicillin-binding protein FOC92_28960 ENOG4108JJB ABC transporter FOC92_28975 ENOG4108HGU Histidine kinase FOC92_29050 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC92_29055 ENOG4105GR3 Histidine kinase FOC92_29060 ENOG4105CB2 alcohol dehydrogenase FOC92_29065 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOC92_29070 ENOG4105CJN penicillin-binding protein FOC92_29115 ENOG4107SWG transcriptional regulator MERR family FOC92_29140 ENOG4107TXC Transcriptional regulator FOC92_29145 ENOG4105F27 Major Facilitator FOC92_29165 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC92_29185 ENOG4107Y9U Membrane FOC92_29205 ENOG4105EGD dinuclear metal center protein, YbgI family FOC92_29230 ENOG4105FCD Major Facilitator FOC92_29245 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC92_29280 ENOG4108XI2 Domain of unknown function (DUF1963) FOC92_29300 ENOG4108NRW Phospholipase, patatin family FOC92_29305 ENOG4105KWG Pfam:DUF1696 FOC92_29330 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC92_29340 ENOG4105PKS Excinuclease abc c subunit domain protein FOC92_29380 ENOG4107VFR oxidoreductase FOC92_29415 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC92_29420 ENOG4105BZU Histidine kinase FOC92_29440 ENOG4107WD8 ABC transporter, permease FOC92_29455 ENOG4105DY8 decarboxylase FOC92_29470 ENOG4108IUM Glycogen debranching enzyme FOC92_29480 ENOG4105CGH 5'-nucleotidase FOC92_29495 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC92_29500 ENOG4105FDR Membrane FOC92_29505 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC92_29555 ENOG4105MSI germination protein ypeb FOC92_29585 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) FOC92_29590 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FOC92_29595 ENOG4107Z3H Transcriptional regulator, TetR family FOC92_29625 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOC92_29640 ENOG4105E98 transcriptional regulator DeoR family FOC92_29655 ENOG41062ES Transcriptional regulator FOC92_29675 ENOG4107QKR Dehydrogenase FOC92_29685 ENOG4107RUY (E1 component), alpha subunit FOC92_29695 ENOG4105JHE Major Facilitator Superfamily FOC92_29705 ENOG4105E1F short-chain dehydrogenase reductase FOC92_29710 ENOG4105RHY Pfam:UPF0157 FOC92_29750 ENOG4107SQ8 Glycine betaine FOC92_29755 ENOG4108IJ7 Glycine betaine FOC92_29780 ENOG4105E66 phosphoriboisomerase A FOC92_29785 ENOG41082BV acetyltransferase FOC92_29790 ENOG4108M1A Chitin-binding protein FOC92_29820 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC92_29825 ENOG4105MSB protein, conserved in bacteria FOC92_29850 ENOG4108Z7F N-acetyltransferase FOC92_29870 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FOC92_29875 ENOG4105EEM helicase FOC92_29885 ENOG41066HZ AIG2-like family FOC92_29890 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC92_29945 ENOG4108M1A Chitin-binding protein FOC92_29960 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC92_29970 ENOG4105BZG amino acid carrier protein FOC92_29975 ENOG4105C26 Dehydrogenase FOC92_29980 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC92_29990 ENOG4105CTU Proline racemase FOC92_29995 ENOG41080HI glycine oxidase FOC92_30005 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FOC92_30040 ENOG4105DCI Phosphohydrolase FOC92_30045 ENOG4107T5V SNARE associated Golgi FOC92_30055 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC92_30075 ENOG4105DTQ mandelate racemase muconate lactonizing FOC92_30090 ENOG4107SET aldo keto reductase FOC92_30125 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FOC92_30130 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC92_30135 ENOG4105BZU Histidine kinase FOC92_30140 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC92_30160 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 FOC92_30175 ENOG4105DPN Oligoendopeptidase f FOC92_30180 ENOG4105EPR degv family FOC92_30240 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC92_30245 ENOG4106K7D Major facilitator family transporter FOC92_30270 ENOG4107BMA Transglycosylase associated protein FOC92_30285 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FOC92_30320 ENOG4105CHM Aminotransferase FOC92_30350 ENOG4105DVE abc transporter atp-binding protein FOC92_30400 ENOG4105C02 permease FOC92_30410 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOC92_30415 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC92_30420 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FOC92_30425 ENOG4105D7T ABC transporter FOC92_30450 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FOC92_30500 ENOG4107VC0 DNA alkylation repair enzyme FOC92_30505 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC92_30520 ENOG4108ZCF integral membrane protein FOC92_30525 ENOG4105E0M Sulfatase FOC92_30530 ENOG4105C5H ABC transporter FOC92_30535 ENOG4105EYF MMPL domain protein FOC92_30540 ENOG41082JN Transcriptional regulator FOC92_30565 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FOC92_30570 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC92_30590 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) FOC92_30615 ENOG41069ER domain protein FOC92_30625 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FOC92_30630 ENOG4105DNP FAD linked oxidase domain protein FOC92_30660 ENOG4105D4B ABC, transporter FOC92_30670 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FOC92_30680 ENOG4105DKT Transcriptional regulator FOC92_30695 ENOG41061GT Aldolase FOC92_30705 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FOC92_30740 ENOG4105II7 pyrroline-5-carboxylate reductase FOC92_30750 ENOG4107258 Transcriptional regulator FOC92_30770 ENOG4105ECK Fatty Acid Desaturase FOC92_30780 ENOG4107RBI VanW family FOC92_30785 ENOG4105G6Z alkaline phosphatase FOC92_30795 ENOG4105VMP Transcriptional regulator FOC92_30815 ENOG41068WN FOC92_30840 ENOG4105C7R Atpase associated with various cellular activities aaa_3