locus-tag class description FOC93_00010 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC93_00030 ENOG4105DVH amino acid FOC93_00045 ENOG4105MZU cell filamentation protein FOC93_00050 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC93_00065 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC93_00075 ENOG4106A3M Cytochrome p-450 FOC93_00095 ENOG4107RA9 decarboxylase FOC93_00140 ENOG4107SCK Monooxygenase FOC93_00145 ENOG4108IFG nitrite reductase, (NAD(P)H) FOC93_00150 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOC93_00155 ENOG4107QHE Choloylglycine hydrolase FOC93_00165 ENOG4108NHD germination protein FOC93_00175 ENOG4105VEQ Cold shock protein FOC93_00195 ENOG4108VJ1 Transcriptional regulator (CarD family FOC93_00225 ENOG4105DRR Transcriptional regulator, GntR family FOC93_00250 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) FOC93_00260 ENOG4108JJA ABC, transporter FOC93_00290 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC93_00330 ENOG4105PF9 Transcriptional regulator FOC93_00335 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC93_00340 ENOG4105C0W non-ribosomal peptide synthetase FOC93_00345 ENOG4107SQU synthase FOC93_00350 ENOG4107SQU synthase FOC93_00355 ENOG4105C0W non-ribosomal peptide synthetase FOC93_00360 ENOG4105C0W non-ribosomal peptide synthetase FOC93_00365 ENOG4107SQU synthase FOC93_00370 ENOG4105C0W non-ribosomal peptide synthetase FOC93_00375 ENOG4105C0W non-ribosomal peptide synthetase FOC93_00380 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC93_00385 ENOG4107QKG PfaD family FOC93_00390 ENOG4108151 Beta-lactamase domain protein FOC93_00415 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC93_00495 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC93_00520 ENOG41067FT ParB-like nuclease domain FOC93_00550 ENOG4105TRI Hydrolase FOC93_00590 ENOG4105IBP Cyclic peptide transporter FOC93_00595 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOC93_00600 ENOG4105C0W non-ribosomal peptide synthetase FOC93_00615 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) FOC93_00620 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC93_00635 ENOG4105C1G acyl-Coa dehydrogenase FOC93_00645 ENOG4105CEY Amp-dependent synthetase and ligase FOC93_00655 ENOG4105C0W non-ribosomal peptide synthetase FOC93_00655 ENOG4105C0W non-ribosomal peptide synthetase FOC93_00670 ENOG4107SDT Homocitrate synthase FOC93_00690 ENOG4105CUZ uba thif-type nad fad binding protein FOC93_00720 ENOG4107QJQ Mate efflux family protein FOC93_00725 ENOG4108WC5 Alpha Beta Hydrolase Fold protein FOC93_00730 ENOG41087PP glycosyltransferase MGT family FOC93_00735 ENOG4105KNA -acetyltransferase FOC93_00750 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) FOC93_00755 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) FOC93_00765 ENOG41080TC multidrug resistance protein FOC93_00790 ENOG4107SET aldo keto reductase FOC93_00810 ENOG4105CFF transcriptional regulator FOC93_00850 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FOC93_00865 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FOC93_00905 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC93_00960 ENOG4105K70 DNA-binding protein FOC93_00980 ENOG4107JM4 Tetratricopeptide repeat FOC93_00985 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC93_01060 ENOG4105CAQ asparagine synthetase FOC93_01065 ENOG4108RZE Tetr family transcriptional regulator FOC93_01160 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC93_01175 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FOC93_01180 ENOG4105DR5 peptidase FOC93_01185 ENOG41065S2 pneumococcal vaccine antigen FOC93_01275 ENOG4105E4C Lytic transglycosylase catalytic FOC93_01285 ENOG41069ER domain protein FOC93_01295 ENOG4107JM4 Tetratricopeptide repeat FOC93_01360 ENOG4105CJW magnesium transporter FOC93_01510 ENOG4105DQ6 Transposase FOC93_01580 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC93_01610 ENOG4105D7V transposase FOC93_01635 ENOG4105KRN Transcriptional regulator, abrb family FOC93_01700 ENOG4105D7V transposase FOC93_01725 ENOG4108IQI permease FOC93_01730 ENOG4108J5H Homocysteine s-methyltransferase FOC93_01740 ENOG4105BZU Histidine kinase FOC93_01745 ENOG4105C19 ABC transporter FOC93_01755 ENOG4105DNP FAD linked oxidase domain protein FOC93_01795 ENOG4105BZ4 penicillin-binding protein FOC93_01840 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC93_01845 ENOG4108BUD transposase FOC93_01855 ENOG4105C19 ABC transporter FOC93_01870 ENOG41081I9 integral membrane protein FOC93_01885 ENOG4108BUD transposase FOC93_01895 ENOG410780I phosphoprotein phosphatase activity FOC93_01975 ENOG4105NA0 Transcriptional regulator FOC93_01980 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC93_02025 ENOG4107SWG transcriptional regulator MERR family FOC93_02030 ENOG4105KNA -acetyltransferase FOC93_02040 ENOG4105CE7 Amidase, hydantoinase carbamoylase family FOC93_02050 ENOG4105G9B Transcriptional regulator FOC93_02160 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) FOC93_02175 ENOG4105BZ1 (ABC) transporter FOC93_02185 ENOG4108WUH Transcriptional regulator, TetR family FOC93_02205 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC93_02215 ENOG4107RN3 metallophosphoesterase FOC93_02250 ENOG4108VHC Short-chain dehydrogenase reductase Sdr FOC93_02255 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC93_02340 ENOG4105D7V transposase FOC93_02375 ENOG4108IAJ Nad-dependent epimerase dehydratase FOC93_02380 ENOG4107QQG Dehydrogenase FOC93_02440 ENOG4105CK5 oxidoreductase FOC93_02445 ENOG4105CK5 oxidoreductase FOC93_02465 ENOG4105CNU cell division protein FtsK FOC93_02625 ENOG4105CID antiterminator FOC93_02630 ENOG4105C5Y PTS System FOC93_02635 ENOG4105CS2 ec 3.2.1.21 FOC93_02735 ENOG4105EKQ RNA-directed DNA polymerase FOC93_02775 ENOG4105D7V transposase FOC93_02800 ENOG4105WKZ CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) FOC93_02815 ENOG4105DHF Membrane FOC93_02885 ENOG4108KS4 Spore coat protein FOC93_02890 ENOG4107SBE Glycosyl transferase (Group 1 FOC93_02910 ENOG4107SBE Glycosyl transferase (Group 1 FOC93_02915 ENOG4108IAJ Nad-dependent epimerase dehydratase FOC93_03145 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC93_03180 ENOG4105F6J Alpha beta hydrolase fold FOC93_03190 ENOG4105F6J Alpha beta hydrolase fold FOC93_03215 ENOG4105XT2 Transcriptional regulator FOC93_03240 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOC93_03250 ENOG4107RSM transcriptional regulator FOC93_03255 ENOG4107AYK membrAne FOC93_03260 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC93_03270 ENOG4105K70 DNA-binding protein FOC93_03290 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC93_03325 ENOG4108W2Y isochorismatase FOC93_03345 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) FOC93_03355 ENOG4105ST3 Transcriptional regulator FOC93_03405 ENOG4108903 Formimidoylglutamase FOC93_03410 ENOG4108VJ1 Transcriptional regulator (CarD family FOC93_03415 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOC93_03420 ENOG4105CBC glutamate synthase FOC93_03430 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FOC93_03435 ENOG4105FBA Phospholipase Carboxylesterase FOC93_03440 ENOG4105BZU Histidine kinase FOC93_03450 ENOG4107AYK membrAne FOC93_03490 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) FOC93_03505 ENOG4105IW1 AmiS UreI transporter FOC93_03510 ENOG4105D9G High-affinity FOC93_03535 ENOG4108IMY Transcriptional regulator FOC93_03540 ENOG4105CEY Amp-dependent synthetase and ligase FOC93_03545 ENOG4107ZYJ bioY protein FOC93_03550 ENOG4107F3J Amp-dependent synthetase and ligase FOC93_03570 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC93_03580 ENOG4105E5W Transporter FOC93_03610 ENOG4108I0Z Aconitate hydratase FOC93_03615 ENOG4105BZ1 (ABC) transporter FOC93_03630 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC93_03635 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC93_03665 ENOG4105W8X HesB YadR YfhF-family protein FOC93_03675 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOC93_03685 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC93_03690 ENOG4105C0H protease FOC93_03695 ENOG4105K4P CoA-binding domain protein FOC93_03700 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC93_03710 ENOG4105D9R oxidoreductase FOC93_03730 ENOG4105CIG ABC transporter FOC93_03740 ENOG4105EMN RNA polymerase sigma factor FOC93_03750 ENOG4108KGH TRANSCRIPTIONal FOC93_03805 ENOG4105CUB amino acid FOC93_03820 ENOG4105E1K spore germination protein FOC93_03825 ENOG4108JB9 formate dehydrogenase FOC93_03835 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FOC93_03840 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC93_03850 ENOG4105TMB Formate nitrite transporter FOC93_03855 ENOG4105D06 uba thif-type nad fad binding protein FOC93_03860 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC93_03865 ENOG4108ZAF Molybdopterin FOC93_03875 ENOG4105D1F ATP-binding protein FOC93_03890 ENOG410696E Membrane FOC93_03895 ENOG4105FR1 rard protein FOC93_03905 ENOG4105EWU Squalene--hopene cyclase FOC93_03915 ENOG4105CHR reductase FOC93_03920 ENOG4105C26 Dehydrogenase FOC93_03930 ENOG4108IA2 Sodium pantothenate symporter FOC93_03945 ENOG4106IQC argininosuccinate lyase FOC93_03955 ENOG410904N short-chain dehydrogenase reductase FOC93_03975 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOC93_04000 ENOG4105VEQ Cold shock protein FOC93_04015 ENOG4108R1P FOC93_04025 ENOG41073R8 VanW family FOC93_04030 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC93_04040 ENOG4105KT7 mgtC SapB transporter FOC93_04050 ENOG4105BZU Histidine kinase FOC93_04070 ENOG4107DUR UPF0457 protein FOC93_04080 ENOG4105C5H ABC transporter FOC93_04085 ENOG4105BZU Histidine kinase FOC93_04145 ENOG4105D7V transposase FOC93_04150 ENOG4105FAW cDP-glucose 4,6-dehydratase FOC93_04155 ENOG4108IAJ Nad-dependent epimerase dehydratase FOC93_04165 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FOC93_04185 ENOG4105E1K spore germination protein FOC93_04195 ENOG4108M1A Chitin-binding protein FOC93_04200 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C FOC93_04210 ENOG4105CEP NADH dehydrogenase FOC93_04215 ENOG4107TPS domain protein FOC93_04220 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC93_04245 ENOG4105CQB FAD linked oxidase domain protein FOC93_04270 ENOG4105CIS alcohol dehydrogenase FOC93_04275 ENOG41082BM Transcriptional regulator, arsr family FOC93_04285 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC93_04310 ENOG4108A04 Beta-lactamase FOC93_04315 ENOG4105DPN Oligoendopeptidase f FOC93_04320 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FOC93_04330 ENOG4105C98 muts2 protein FOC93_04345 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC93_04355 ENOG4107V2S Transcriptional regulator FOC93_04365 ENOG4107CUJ Protein of unknown function (DUF2690) FOC93_04370 ENOG41068WN FOC93_04395 ENOG4105DQ5 transport system permease protein FOC93_04400 ENOG4105EHG Permease protein FOC93_04405 ENOG4108MES Periplasmic binding protein FOC93_04410 ENOG4105WCN acetyltransferase FOC93_04420 ENOG4107R3E Citrate transporter FOC93_04430 ENOG4108TN2 lmbE family FOC93_04500 ENOG4105H3G oxidoreductase FOC93_04525 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FOC93_04555 ENOG4105KAF membrAne FOC93_04575 ENOG410829K Lysine exporter protein (Lyse ygga) FOC93_04630 ENOG4105KVH Transcriptional regulator FOC93_04635 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FOC93_04645 ENOG4105JAB phenazine biosynthesis protein, phzf family FOC93_04685 ENOG4105D9R oxidoreductase FOC93_04690 ENOG4108TZY GntR Family Transcriptional Regulator FOC93_04720 ENOG4105C44 Serine transporter FOC93_04745 ENOG4105KVH Transcriptional regulator FOC93_04750 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FOC93_04755 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC93_04760 ENOG4108UX3 '-nucleotidase FOC93_04765 ENOG4105C8Q Methyl-accepting chemotaxis FOC93_04790 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOC93_04795 ENOG4105CV1 Transketolase (EC 2.2.1.1) FOC93_04805 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC93_04810 ENOG4105C6Z Gluconate FOC93_04815 ENOG4105CMG Carbohydrate kinase FOC93_04820 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOC93_04825 ENOG4105XDF Protein of unknown function (DUF1272) FOC93_04830 ENOG4105DDN Pentapeptide repeat-containing protein FOC93_04860 ENOG4105FAW cDP-glucose 4,6-dehydratase FOC93_04865 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FOC93_04880 ENOG4105C37 (CBS) domain FOC93_04910 ENOG4105EV4 Multidrug resistance protein mdtH FOC93_05025 ENOG4108PSK reductase FOC93_05055 ENOG4108RCM Nitroreductase FOC93_05060 ENOG4105KVH Transcriptional regulator FOC93_05075 ENOG4105CUT histidyl-tRNA synthetase FOC93_05080 ENOG4108Z66 YbaK ebsC protein FOC93_05100 ENOG4108K8S endonuclease I FOC93_05160 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC93_05170 ENOG4105CRW Short chain fatty acid transporter FOC93_05185 ENOG4105CZM Major Facilitator FOC93_05190 ENOG4107MII Sugar-specific transcriptional regulator TrmB FOC93_05205 ENOG4108ISG Major Facilitator FOC93_05215 ENOG4105PNM synthesis protein FOC93_05220 ENOG4108VXD carboxy-peptidase FOC93_05335 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC93_05370 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FOC93_05405 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC93_05415 ENOG4105BZU Histidine kinase FOC93_05435 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FOC93_05455 ENOG4105JQZ Methyltransferase FOC93_05465 ENOG4105E0Y RtcB Protein FOC93_05475 ENOG4105K6H D-cysteine desulfhydrase FOC93_05490 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC93_05495 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOC93_05590 ENOG4108YXU transcriptional regulator AsnC family FOC93_05595 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FOC93_05600 ENOG4105M4P Tetr family transcriptional regulator FOC93_05605 ENOG4105F27 Major Facilitator FOC93_05625 ENOG4105EQ0 Major Facilitator superfamily FOC93_05630 ENOG4108JGH Tetr family transcriptional regulator FOC93_05635 ENOG4108IG5 Transcriptional regulator FOC93_05640 ENOG4107P5I polyketide synthase FOC93_05665 ENOG4105NAE bifunctional deaminase-reductase domain protein FOC93_05690 ENOG41085FC arsR family transcriptional regulator FOC93_05695 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC93_05700 ENOG4105D6J arsenicaL-resistance protein FOC93_05710 ENOG4105Z7P Acetyltransferase (GNAT) family FOC93_05715 ENOG4105ECQ AraC Family Transcriptional Regulator FOC93_05720 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC93_05735 ENOG4105C57 major facilitator superfamily FOC93_05740 ENOG41062ES Transcriptional regulator FOC93_05775 ENOG4105FR1 rard protein FOC93_05790 ENOG4108VJ1 Transcriptional regulator (CarD family FOC93_05815 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC93_05820 ENOG4105BZU Histidine kinase FOC93_05825 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FOC93_05840 ENOG4106P55 Transcriptional regulator FOC93_05845 ENOG4105F27 Major Facilitator FOC93_05850 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FOC93_05855 ENOG4108TWJ NADH dehydrogenase subunit 5 FOC93_05870 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOC93_05875 ENOG4108606 TspO/MBR family FOC93_05890 ENOG4105F6J Alpha beta hydrolase fold FOC93_05945 ENOG4105EQ0 Major Facilitator superfamily FOC93_05970 ENOG4105CHJ isochorismatase hydrolase FOC93_05980 ENOG4105CGH 5'-nucleotidase FOC93_06030 ENOG4108Q8B Spore germination protein FOC93_06035 ENOG4108NHD germination protein FOC93_06040 ENOG4105II7 pyrroline-5-carboxylate reductase FOC93_06045 ENOG4105CUB amino acid FOC93_06050 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC93_06055 ENOG4105YWU small acid-soluble spore protein FOC93_06065 ENOG41075H3 AraC family transcriptional regulator FOC93_06090 ENOG4105BZU Histidine kinase FOC93_06100 ENOG4108B31 Spore germination protein FOC93_06125 ENOG4108IMY Transcriptional regulator FOC93_06130 ENOG4105HDK L-asparaginase FOC93_06135 ENOG4108IJ0 Aspartate ammonia-lyase FOC93_06145 ENOG4105E2A Dehydrogenase FOC93_06170 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC93_06195 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOC93_06230 ENOG4105DWD nucleoside recognition domain protein FOC93_06245 ENOG4105FDT acyl-CoA dehydrogenase FOC93_06255 ENOG4108ZHR arsR family transcriptional regulator FOC93_06260 ENOG4106N3A copper homeostasis protein cutc FOC93_06270 ENOG4107258 Transcriptional regulator FOC93_06275 ENOG4105P4J Allophanate hydrolase, subunit 1 FOC93_06285 ENOG4105E7W lamb ycsf family protein FOC93_06305 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FOC93_06310 ENOG4107RF6 penicillin-binding protein FOC93_06345 ENOG4105F1N DNA alkylation repair FOC93_06355 ENOG4108IQI permease FOC93_06365 ENOG410635A Membrane FOC93_06410 ENOG4108PCN EamA-like transporter family FOC93_06425 ENOG4108XET gCN5-related N-acetyltransferase FOC93_06430 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) FOC93_06470 ENOG4105FS7 Transcriptional regulator FOC93_06475 ENOG4108TVJ Nitroreductase FOC93_06560 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC93_06605 ENOG4105C8Y Acetylornithine aminotransferase FOC93_06630 ENOG4105CKK Glycosyl transferase, family 2 FOC93_06640 ENOG4105CSH Transporter FOC93_06655 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC93_06680 ENOG41068WN FOC93_06700 ENOG4105VMP Transcriptional regulator FOC93_06710 ENOG4105G6Z alkaline phosphatase FOC93_06715 ENOG4107RBI VanW family FOC93_06725 ENOG4105ECK Fatty Acid Desaturase FOC93_06740 ENOG4107258 Transcriptional regulator FOC93_06750 ENOG4105II7 pyrroline-5-carboxylate reductase FOC93_06785 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FOC93_06795 ENOG41061GT Aldolase FOC93_06810 ENOG4105DKT Transcriptional regulator FOC93_06820 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FOC93_06830 ENOG4105D4B ABC, transporter FOC93_06860 ENOG4105DNP FAD linked oxidase domain protein FOC93_06865 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FOC93_06875 ENOG41069ER domain protein FOC93_06900 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) FOC93_06920 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC93_06925 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FOC93_06950 ENOG41082JN Transcriptional regulator FOC93_06955 ENOG4105EYF MMPL domain protein FOC93_06960 ENOG4105C5H ABC transporter FOC93_06965 ENOG4105E0M Sulfatase FOC93_06970 ENOG4108ZCF integral membrane protein FOC93_06985 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FOC93_06990 ENOG4107VC0 DNA alkylation repair enzyme FOC93_07040 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FOC93_07065 ENOG4105D7T ABC transporter FOC93_07070 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FOC93_07075 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOC93_07080 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOC93_07090 ENOG4105C02 permease FOC93_07140 ENOG4105DVE abc transporter atp-binding protein FOC93_07170 ENOG4105CHM Aminotransferase FOC93_07205 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FOC93_07220 ENOG4107BMA Transglycosylase associated protein FOC93_07245 ENOG4106K7D Major facilitator family transporter FOC93_07250 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC93_07310 ENOG4105EPR degv family FOC93_07315 ENOG4105DPN Oligoendopeptidase f FOC93_07330 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 FOC93_07350 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC93_07355 ENOG4105BZU Histidine kinase FOC93_07360 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC93_07365 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FOC93_07400 ENOG4107SET aldo keto reductase FOC93_07415 ENOG4105DTQ mandelate racemase muconate lactonizing FOC93_07435 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC93_07445 ENOG4107T5V SNARE associated Golgi FOC93_07450 ENOG4105DCI Phosphohydrolase FOC93_07485 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FOC93_07495 ENOG41080HI glycine oxidase FOC93_07500 ENOG4105CTU Proline racemase FOC93_07510 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC93_07515 ENOG4105C26 Dehydrogenase FOC93_07520 ENOG4105BZG amino acid carrier protein FOC93_07530 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC93_07545 ENOG4108M1A Chitin-binding protein FOC93_07600 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC93_07605 ENOG41066HZ AIG2-like family FOC93_07615 ENOG4105EEM helicase FOC93_07620 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FOC93_07640 ENOG4108Z7F N-acetyltransferase FOC93_07665 ENOG4105MSB protein, conserved in bacteria FOC93_07670 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC93_07700 ENOG4108M1A Chitin-binding protein FOC93_07705 ENOG41082BV acetyltransferase FOC93_07710 ENOG4105E66 phosphoriboisomerase A FOC93_07735 ENOG4108IJ7 Glycine betaine FOC93_07740 ENOG4107SQ8 Glycine betaine FOC93_07780 ENOG4105RHY Pfam:UPF0157 FOC93_07785 ENOG4105E1F short-chain dehydrogenase reductase FOC93_07795 ENOG4105JHE Major Facilitator Superfamily FOC93_07805 ENOG4107RUY (E1 component), alpha subunit FOC93_07815 ENOG4107QKR Dehydrogenase FOC93_07835 ENOG41062ES Transcriptional regulator FOC93_07850 ENOG4105E98 transcriptional regulator DeoR family FOC93_07865 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOC93_07895 ENOG4107Z3H Transcriptional regulator, TetR family FOC93_07900 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FOC93_07905 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) FOC93_07935 ENOG4105MSI germination protein ypeb FOC93_07985 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC93_07990 ENOG4105FDR Membrane FOC93_07995 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC93_08010 ENOG4105CGH 5'-nucleotidase FOC93_08020 ENOG4108IUM Glycogen debranching enzyme FOC93_08035 ENOG4105DY8 decarboxylase FOC93_08050 ENOG4107WD8 ABC transporter, permease FOC93_08070 ENOG4105BZU Histidine kinase FOC93_08075 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC93_08110 ENOG4107VFR oxidoreductase FOC93_08150 ENOG4105PKS Excinuclease abc c subunit domain protein FOC93_08160 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC93_08185 ENOG4105KWG Pfam:DUF1696 FOC93_08190 ENOG4108NRW Phospholipase, patatin family FOC93_08210 ENOG4108XI2 Domain of unknown function (DUF1963) FOC93_08245 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC93_08260 ENOG4105FCD Major Facilitator FOC93_08285 ENOG4105EGD dinuclear metal center protein, YbgI family FOC93_08305 ENOG4107Y9U Membrane FOC93_08325 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOC93_08345 ENOG4105F27 Major Facilitator FOC93_08370 ENOG4107TXC Transcriptional regulator FOC93_08375 ENOG4107SWG transcriptional regulator MERR family FOC93_08420 ENOG4105CJN penicillin-binding protein FOC93_08425 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOC93_08430 ENOG4105CB2 alcohol dehydrogenase FOC93_08435 ENOG4105GR3 Histidine kinase FOC93_08440 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC93_08515 ENOG4108HGU Histidine kinase FOC93_08530 ENOG4108JJB ABC transporter FOC93_08560 ENOG4105BZU Histidine kinase FOC93_08565 ENOG410667J hydrolase FOC93_08695 ENOG4105XSJ toxin secretion phage lysis holin FOC93_08790 ENOG4108TFU terminase (Small subunit) FOC93_08885 ENOG4105KNA -acetyltransferase FOC93_08915 ENOG4108SXZ UPF0302 protein FOC93_08940 ENOG4108PNI recT protein FOC93_08950 ENOG4108NF7 phage-type endonuclease FOC93_08980 ENOG4108IMY Transcriptional regulator FOC93_09005 ENOG4105VTR Integrase FOC93_09030 ENOG4105ETU transcriptional activator (TenA FOC93_09035 ENOG4105CPF Cell wall formation (By similarity) FOC93_09045 ENOG4105D6E homoserine dehydrogenase FOC93_09115 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FOC93_09125 ENOG4108V4B ThiJ pfpI FOC93_09130 ENOG410900G Protein of unknown function (DUF421) FOC93_09140 ENOG4105CPQ Dehydrogenase FOC93_09155 ENOG4105EFA 4-hydroxyphenylacetate FOC93_09200 ENOG41089UC methyltransferase, type 11 FOC93_09205 ENOG4105KVH Transcriptional regulator FOC93_09215 ENOG4107Y80 Major Facilitator superfamily FOC93_09240 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC93_09270 ENOG41075H3 AraC family transcriptional regulator FOC93_09290 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FOC93_09300 ENOG4105T9C HD domain FOC93_09315 ENOG4105DZ1 carboxypeptidase FOC93_09335 ENOG4105DBI uridine monophosphokinase FOC93_09365 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC93_09370 ENOG4107QX3 carboxylase FOC93_09375 ENOG4105E39 Enoyl-CoA hydratase FOC93_09380 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOC93_09385 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FOC93_09390 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC93_09395 ENOG4105C1G acyl-Coa dehydrogenase FOC93_09410 ENOG4107Z3H Transcriptional regulator, TetR family FOC93_09420 ENOG4105CJ1 ABC, transporter FOC93_09430 ENOG4105DIN metallophosphoesterase FOC93_09440 ENOG4107RF6 penicillin-binding protein FOC93_09445 ENOG4107RF6 penicillin-binding protein FOC93_09460 ENOG4107RVG penicillin-binding protein FOC93_09485 ENOG4107QHE Choloylglycine hydrolase FOC93_09495 ENOG4105CVK Glutamate decarboxylase FOC93_09505 ENOG4105F6S Spore photoproduct lyase FOC93_09525 ENOG4105C44 Serine transporter FOC93_09530 ENOG4105EJQ L-serine dehydratase FOC93_09555 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC93_09565 ENOG4108XG2 Histidine kinase FOC93_09570 ENOG4105CAQ asparagine synthetase FOC93_09575 ENOG4108RZE Tetr family transcriptional regulator FOC93_09595 ENOG4108IMY Transcriptional regulator FOC93_09660 ENOG4105CHR reductase FOC93_09670 ENOG4105W8Z 4'-phosphopantetheinyl transferase FOC93_09710 ENOG4105EQK -acetyltransferase FOC93_09715 ENOG4105EJ9 Membrane FOC93_09725 ENOG4105KRN Transcriptional regulator, abrb family FOC93_09750 ENOG4105CIN aminoacyl-histidine dipeptidase FOC93_09775 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FOC93_09780 ENOG4105K56 Transcriptional regulator FOC93_09785 ENOG4107RA9 decarboxylase FOC93_09790 ENOG4108I0C methyltransferase FOC93_09800 ENOG41088CC tellurite resistance protein tehB FOC93_09830 ENOG4108RZE Tetr family transcriptional regulator FOC93_09840 ENOG4105C1J atp-dependent rna helicase FOC93_09850 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC93_09865 ENOG4108INS Transcriptional regulator FOC93_09875 ENOG4107STF Involved in phosphonate degradation (By similarity) FOC93_09880 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FOC93_09885 ENOG4105RD7 BadF BadG BcrA BcrD FOC93_09910 ENOG4105F32 YngK protein FOC93_09940 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) FOC93_09975 ENOG4108JCI Transcriptional regulator FOC93_10000 ENOG4105BZ1 (ABC) transporter FOC93_10005 ENOG4105BZ1 (ABC) transporter FOC93_10020 ENOG4108RPX mosc domain containing protein FOC93_10025 ENOG4105DND Transcriptional regulator FOC93_10045 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC93_10050 ENOG4107V2S Transcriptional regulator FOC93_10080 ENOG41068WN FOC93_10090 ENOG4105C1Q protoporphyrinogen oxidase FOC93_10115 ENOG4105WCN acetyltransferase FOC93_10145 ENOG4105EYF MMPL domain protein FOC93_10155 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOC93_10180 ENOG41081I9 integral membrane protein FOC93_10220 ENOG4105C19 ABC transporter FOC93_10225 ENOG4105C22 threonyL-tRNA synthetase FOC93_10230 ENOG4105FE9 pseudouridine synthase FOC93_10250 ENOG4105BZG amino acid carrier protein FOC93_10270 ENOG4105K70 DNA-binding protein FOC93_10285 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC93_10290 ENOG4105WQT MbtH domain protein FOC93_10295 ENOG4105CEY Amp-dependent synthetase and ligase FOC93_10300 ENOG4105WQI isochorismatase FOC93_10305 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FOC93_10310 ENOG4105E4F Isochorismate synthase FOC93_10315 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FOC93_10320 ENOG4105FCD Major Facilitator FOC93_10340 ENOG4105EYH Exonuclease FOC93_10345 ENOG4107RFY SbcCD D subunit FOC93_10360 ENOG4105E39 Enoyl-CoA hydratase FOC93_10365 ENOG4105N14 lysine exporter protein LysE YggA FOC93_10375 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC93_10380 ENOG4105C1G acyl-Coa dehydrogenase FOC93_10385 ENOG4105CR4 methylisocitrate lyase FOC93_10390 ENOG4105DXD 2-methylcitrate dehydratase FOC93_10400 ENOG4105W8X HesB YadR YfhF-family protein FOC93_10405 ENOG4105CZM Major Facilitator FOC93_10415 ENOG4105BZ4 penicillin-binding protein FOC93_10480 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC93_10515 ENOG4105SZ6 Thioredoxin FOC93_10525 ENOG410841Q phosphoesterase PA-phosphatase related protein FOC93_10570 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FOC93_10575 ENOG4108JUB Transcriptional regulator FOC93_10580 ENOG4108TSC N-acetyltransferase FOC93_10585 ENOG4107S4Y M20 DapE family protein YgeY FOC93_10600 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC93_10625 ENOG4105C37 (CBS) domain FOC93_10660 ENOG4105E90 ABC transporter FOC93_10665 ENOG4108IJ8 ABC transporter FOC93_10695 ENOG4108YV3 Protein of unknown function (DUF2711) FOC93_10705 ENOG4105C6Z Gluconate FOC93_10710 ENOG4105CMG Carbohydrate kinase FOC93_10730 ENOG4107ZY0 Phenazine biosynthesis-like protein FOC93_10735 ENOG4106KNT transcriptional regulator FOC93_10740 ENOG4105WH1 Two component transcriptional regulator luxr family FOC93_10745 ENOG4105BZU Histidine kinase FOC93_10750 ENOG4105D8X mechanosensitive ion channel FOC93_10785 ENOG4105F0I Aminotransferase FOC93_10790 ENOG4108MES Periplasmic binding protein FOC93_10810 ENOG4105CAQ asparagine synthetase FOC93_10815 ENOG4107Y70 Heat shock protein FOC93_10820 ENOG4108KF3 Electron transport protein SCO1 SenC FOC93_10830 ENOG4108RCR degv family FOC93_10840 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOC93_10850 ENOG4108UT2 hemolysin iii FOC93_10855 ENOG4105E9Q Acyl-transferase FOC93_10860 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOC93_10865 ENOG4107RVG penicillin-binding protein FOC93_10875 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FOC93_10880 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FOC93_10895 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FOC93_10920 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FOC93_10925 ENOG4105VMP Transcriptional regulator FOC93_10935 ENOG4105KD7 acetyltransferase FOC93_10955 ENOG4105CY2 Citrate transporter FOC93_10960 ENOG4107XGZ Hydrolase FOC93_10980 ENOG4105C8J )-transporter FOC93_10985 ENOG4105C5S asparaginyl-tRNA synthetase FOC93_11010 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FOC93_11035 ENOG4105C75 arginyL-tRNA synthetase FOC93_11040 ENOG4107YX5 Pfam:DUF548 FOC93_11065 ENOG4108UUM single-stranded DNA-binding protein FOC93_11080 ENOG4105C5H ABC transporter FOC93_11120 ENOG4105MCT stage V sporulation protein S FOC93_11155 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FOC93_11160 ENOG4108IFG nitrite reductase, (NAD(P)H) FOC93_11165 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOC93_11170 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC93_11175 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC93_11180 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC93_11205 ENOG41067WU Molybdopterin converting factor (Subunit 1) FOC93_11210 ENOG4108ZAF Molybdopterin FOC93_11215 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC93_11220 ENOG4105D06 uba thif-type nad fad binding protein FOC93_11225 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC93_11230 ENOG4107V6Q Cyclic nucleotide-binding domain FOC93_11240 ENOG4105R3A Nitrate reductase FOC93_11245 ENOG4108IUE nitrate reductase beta subunit FOC93_11255 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOC93_11270 ENOG4108V06 Glutathione peroxidase FOC93_11280 ENOG4105CNW domain protein FOC93_11295 ENOG4105EMN RNA polymerase sigma factor FOC93_11300 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FOC93_11310 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FOC93_11330 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC93_11355 ENOG4105KBJ sporulation protein ytfj FOC93_11360 ENOG4105D7V transposase FOC93_11445 ENOG4108MGT Required for secretion of EsxA and EsxB FOC93_11480 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC93_11510 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC93_11515 ENOG4108JYZ YitT family FOC93_11520 ENOG41087PP glycosyltransferase MGT family FOC93_11535 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC93_11550 ENOG4108X4Q Hydrolase FOC93_11560 ENOG4108ZRV stage ii sporulation protein p FOC93_11590 ENOG4108VXD carboxy-peptidase FOC93_11600 ENOG4108ZRV stage ii sporulation protein p FOC93_11620 ENOG4108Z7R Chaperone CsaA FOC93_11640 ENOG4105C37 (CBS) domain FOC93_11645 ENOG4105SXS Protein of unknown function (DUF456) FOC93_11665 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC93_11675 ENOG4108S4H thioesterase Superfamily protein FOC93_11685 ENOG4108PJD permease FOC93_11700 ENOG4107T5V SNARE associated Golgi FOC93_11745 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC93_11755 ENOG4105K4T epimerase FOC93_11765 ENOG4105DSE periplasmic solute binding protein FOC93_11775 ENOG4105CKI cobalamin synthesis protein FOC93_11780 ENOG4107QM2 Aldo Keto reductase FOC93_11785 ENOG4105VMI -acetyltransferase FOC93_11800 ENOG4105DEN Luciferase family FOC93_11815 ENOG4108WPJ Ferritin-like domain FOC93_11820 ENOG4108K88 Membrane FOC93_11835 ENOG4105C8Q Methyl-accepting chemotaxis FOC93_11860 ENOG4107XZQ multidrug resistance protein FOC93_11865 ENOG4105CPC Aldo Keto reductase FOC93_11870 ENOG4105YVS arsR family transcriptional regulator FOC93_11880 ENOG4105KRN Transcriptional regulator, abrb family FOC93_11930 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC93_11935 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FOC93_11945 ENOG4105YWU small acid-soluble spore protein FOC93_11950 ENOG4108WBH protein TIM barrel FOC93_11965 ENOG4105CEY Amp-dependent synthetase and ligase FOC93_11970 ENOG4105DUU IucA IucC family protein FOC93_11985 ENOG4105KT7 mgtC SapB transporter FOC93_12000 ENOG4105BZU Histidine kinase FOC93_12005 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC93_12015 ENOG4108KGH TRANSCRIPTIONal FOC93_12030 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FOC93_12040 ENOG4105D6E homoserine dehydrogenase FOC93_12065 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FOC93_12075 ENOG4105BZU Histidine kinase FOC93_12080 ENOG4105EFI regulatoR FOC93_12085 ENOG4105BZ1 (ABC) transporter FOC93_12140 ENOG4108UT6 Transferase hexapeptide repeat containing protein FOC93_12150 ENOG4105K64 Glycosyl transferase, family 2 FOC93_12160 ENOG4108JJ8 (ABC) transporter FOC93_12165 ENOG4108JJ9 ABC, transporter FOC93_12170 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC93_12175 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC93_12195 ENOG4105SKE transcriptional Regulator LysR family FOC93_12205 ENOG4105C32 Amino acid ABC transporter (Permease) FOC93_12210 ENOG4108IV0 ABC, transporter FOC93_12215 ENOG4105C0Z ABC transporter FOC93_12225 ENOG4105CKI cobalamin synthesis protein FOC93_12240 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC93_12245 ENOG4106F5Q Membrane FOC93_12250 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOC93_12255 ENOG4108TVJ Nitroreductase FOC93_12260 ENOG4107ZXU DSBA oxidoreductase FOC93_12265 ENOG4108Z40 Transcriptional regulator FOC93_12270 ENOG4105GZI Transcriptional regulator FOC93_12275 ENOG4107RT3 EamA-like transporter family FOC93_12280 ENOG4105KTB nuclear export factor GLE1 FOC93_12285 ENOG4108T5E Copper resistance protein FOC93_12325 ENOG4107R16 Multicopper oxidase FOC93_12335 ENOG4107RAQ aminopeptidase FOC93_12365 ENOG4108IBT Inherit from COG: transposase FOC93_12385 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FOC93_12390 ENOG4105D9N nucleoside FOC93_12400 ENOG4107RHR regulatoR FOC93_12415 ENOG4105K8R UPF0145 protein FOC93_12440 ENOG4105C0X amino acid FOC93_12445 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOC93_12460 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOC93_12480 ENOG41068WN FOC93_12500 ENOG4105K5X acetyltransferase FOC93_12505 ENOG4105CYC Transferase FOC93_12510 ENOG4105DY9 regulatoR FOC93_12520 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FOC93_12525 ENOG4105C6X Major Facilitator FOC93_12550 ENOG4105C7B Threonine dehydratase FOC93_12555 ENOG4105C01 Dihydroxy-acid dehydratase FOC93_12560 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC93_12570 ENOG4105C7K acetolactate synthase FOC93_12575 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC93_12580 ENOG4105CHR reductase FOC93_12585 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOC93_12605 ENOG4105H67 Protein of unknown function (DUF421) FOC93_12610 ENOG4105X5K response regulator receiver protein FOC93_12615 ENOG4105C8J )-transporter FOC93_12635 ENOG4105C6T cysteine synthase FOC93_12640 ENOG4105EU0 Major facilitator Superfamily FOC93_12645 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC93_12655 ENOG4105DXI Major Facilitator superfamily FOC93_12665 ENOG4105U3E Transcriptional regulator FOC93_12670 ENOG4105CSR polyphosphate kinase 2 FOC93_12685 ENOG4105FVX FOC93_12735 ENOG4105C6K Malic enzyme FOC93_12740 ENOG4108IJ0 Aspartate ammonia-lyase FOC93_12750 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC93_12775 ENOG4105CJ1 ABC, transporter FOC93_12810 ENOG4106BRA Membrane FOC93_12870 ENOG4105C2M dna polymerase I FOC93_12895 ENOG4105K63 Thioredoxin FOC93_12935 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC93_13120 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC93_13145 ENOG4105EC3 peptidase S51, dipeptidase E FOC93_13150 ENOG4107QJQ Mate efflux family protein FOC93_13170 ENOG4105C9Q fumarate hydratase class II FOC93_13180 ENOG4105VUF Transcriptional regulator FOC93_13185 ENOG4105DFD Na H antiporter FOC93_13200 ENOG4108PJD permease FOC93_13205 ENOG4105CKI cobalamin synthesis protein FOC93_13215 ENOG4108UZ3 Transporter FOC93_13220 ENOG4105DRR Transcriptional regulator, GntR family FOC93_13230 ENOG4105PGM cation diffusion facilitator family transporter FOC93_13250 ENOG4105CAQ asparagine synthetase FOC93_13270 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FOC93_13280 ENOG4105CVJ phosphoglycerate mutase FOC93_13315 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FOC93_13320 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC93_13355 ENOG4105KAC Antibiotic biosynthesis monooxygenase FOC93_13390 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC93_13395 ENOG4105KTQ flagellar basal-body rod protein FOC93_13400 ENOG4105FZW flagellar biosynthesis regulator FlhF FOC93_13405 ENOG4105D7B Flagellar biosynthesis protein flha FOC93_13410 ENOG4105D00 flagellar biosynthetic protein flhB FOC93_13420 ENOG4105VS8 Flagellar biosynthetic protein fliq FOC93_13425 ENOG4105CN7 Flagellar biosynthetic protein FliP FOC93_13435 ENOG4105DD5 Flagellar motor switch protein FOC93_13440 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC93_13450 ENOG4105E4C Lytic transglycosylase catalytic FOC93_13455 ENOG4105I03 Flagellin FOC93_13460 ENOG4105I03 Flagellin FOC93_13470 ENOG4107R88 Chemotaxis protein (CheV) FOC93_13485 ENOG4105BZE flagellar hook protein, FlgE FOC93_13515 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOC93_13520 ENOG4107U2N Flagellar M-ring protein FOC93_13530 ENOG4108ZC9 flagellar basal-body rod protein flgc FOC93_13535 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOC93_13550 ENOG4105DTS flagellar hook-associated FOC93_13555 ENOG4105DTJ flagellar hook-associated protein FOC93_13560 ENOG4105E1Q flagellar hook-associated protein FOC93_13580 ENOG4105BZU Histidine kinase FOC93_13595 ENOG4105DD5 Flagellar motor switch protein FOC93_13600 ENOG4105CBS Chea signal transduction histidine kinase FOC93_13605 ENOG4107YTP response regulator receiver protein FOC93_13610 ENOG4105ER2 Ompa motb domain protein FOC93_13615 ENOG4107R0U MotA TolQ exbB proton channel FOC93_13625 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOC93_13665 ENOG41080C8 DUF218 domain FOC93_13670 ENOG4105H67 Protein of unknown function (DUF421) FOC93_13680 ENOG4108Z5V transcriptional regulator, merr family FOC93_13685 ENOG4105CN5 Metallo-Beta-Lactamase FOC93_13690 ENOG4107RWR Sodium hydrogen exchanger FOC93_13700 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC93_13765 ENOG41081VK Ribonuclease FOC93_13785 ENOG4108SZE gCN5-related N-acetyltransferase FOC93_13800 ENOG4105CPK Glycosyl transferase (Group 1 FOC93_13830 ENOG4105HTX biosynthesis protein FOC93_13885 ENOG4105KHC sulfurtransferase FOC93_13895 ENOG4108W0I acetyltransferase FOC93_13905 ENOG410890F Dynamin family FOC93_13915 ENOG4105DHF Membrane FOC93_13920 ENOG4105C2W permease FOC93_13930 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC93_13940 ENOG4105CTD carboxy-peptidase FOC93_13945 ENOG4105DVT helicase FOC93_13955 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOC93_14010 ENOG4105BZ4 penicillin-binding protein FOC93_14020 ENOG4105CSM endonuclease III FOC93_14040 ENOG4105YAC FOC93_14045 ENOG4105DVT helicase FOC93_14060 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FOC93_14080 ENOG4105CPK Glycosyl transferase (Group 1 FOC93_14085 ENOG4105FJR Lmbe family FOC93_14100 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FOC93_14105 ENOG4108JYZ YitT family FOC93_14140 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOC93_14145 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FOC93_14160 ENOG41068YB TPR repeat-containing protein FOC93_14175 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FOC93_14180 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FOC93_14185 ENOG4105EAH synthase FOC93_14195 ENOG4105XXQ heptaprenyl diphosphate synthase component I FOC93_14210 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FOC93_14240 ENOG41065D1 FOC93_14245 ENOG4105S2F FOC93_14260 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FOC93_14280 ENOG4107RB3 L-asparaginase FOC93_14285 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FOC93_14310 ENOG4108S6Z Negative regulator of genetic competence FOC93_14315 ENOG4108XDN Transcriptional regulator FOC93_14320 ENOG4107RGJ metallophosphoesterase FOC93_14330 ENOG4105I7S Abortive infection protein FOC93_14335 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC93_14350 ENOG4108SAX Membrane FOC93_14365 ENOG4108WBT adenosyltransferase FOC93_14370 ENOG4105BZU Histidine kinase FOC93_14375 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC93_14380 ENOG4105CRE cytochrome C FOC93_14385 ENOG4107TWT Cytochrome c biogenesis protein FOC93_14390 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC93_14395 ENOG4105FE9 pseudouridine synthase FOC93_14405 ENOG4108JIC nucleoside recognition domain protein FOC93_14410 ENOG4105DZ1 carboxypeptidase FOC93_14415 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC93_14445 ENOG4105BZU Histidine kinase FOC93_14460 ENOG4105I3N Conserved Protein FOC93_14465 ENOG4105BZU Histidine kinase FOC93_14480 ENOG4105BZ4 penicillin-binding protein FOC93_14485 ENOG4107GRR phosphate transport regulator FOC93_14490 ENOG4105CJ3 phosphate transporter FOC93_14510 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FOC93_14535 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOC93_14555 ENOG4105WH1 Two component transcriptional regulator luxr family FOC93_14560 ENOG4105ENE Histidine kinase FOC93_14580 ENOG4105DFD Na H antiporter FOC93_14610 ENOG4105C8J )-transporter FOC93_14615 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOC93_14620 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOC93_14625 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOC93_14635 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FOC93_14640 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FOC93_14645 ENOG4107S4M Sulfate adenylate transferase FOC93_14660 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOC93_14670 ENOG4105E0M Sulfatase FOC93_14675 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC93_14690 ENOG4107RVV histidinol phosphate phosphatase, hisj family FOC93_14705 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FOC93_14710 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FOC93_14715 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FOC93_14720 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FOC93_14725 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FOC93_14730 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FOC93_14745 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FOC93_14760 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOC93_14765 ENOG4108ZP8 Acetolactate synthase small subunit FOC93_14770 ENOG4105C7K acetolactate synthase FOC93_14775 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOC93_14795 ENOG4105KBJ sporulation protein ytfj FOC93_14800 ENOG41063Y9 FOC93_14805 ENOG4105CZN Potassium uptake protein FOC93_14875 ENOG4105NQC Flavodoxin FOC93_14900 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOC93_14910 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOC93_14915 ENOG4105EA8 2-Nitropropane dioxygenase FOC93_14920 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOC93_14960 ENOG4105CJ1 ABC, transporter FOC93_14970 ENOG4105CZV ABC transporter FOC93_14975 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC93_14980 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC93_14985 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOC93_14990 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOC93_15030 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOC93_15035 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FOC93_15040 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FOC93_15045 ENOG4105BZU Histidine kinase FOC93_15050 ENOG4106DF1 FOC93_15060 ENOG41090MY MarR family Transcriptional regulator FOC93_15065 ENOG4105BZU Histidine kinase FOC93_15075 ENOG4105PXI polysaccharide deacetylase FOC93_15085 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FOC93_15095 ENOG4105E98 transcriptional regulator DeoR family FOC93_15115 ENOG4107RCV ABC transporter, permease FOC93_15120 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC93_15125 ENOG4105C4Y ABC transporter FOC93_15155 ENOG4105CHR reductase FOC93_15175 ENOG4108Z7G MaoC domain protein dehydratase FOC93_15180 ENOG410681C small acid-soluble spore protein FOC93_15185 ENOG4105CZN Potassium uptake protein FOC93_15190 ENOG4107TS3 membrane protein, TerC FOC93_15195 ENOG4108QTI )-transporter FOC93_15205 ENOG4106A3R peptidase FOC93_15225 ENOG4105JXH GntR family transcriptional regulator FOC93_15230 ENOG4105BZU Histidine kinase FOC93_15235 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC93_15250 ENOG4105CQB FAD linked oxidase domain protein FOC93_15255 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOC93_15260 ENOG4105K4I Scp-like extracellular FOC93_15270 ENOG4108YBP pseudouridine synthase FOC93_15280 ENOG4105EYF MMPL domain protein FOC93_15290 ENOG4108HM4 ABC transporter FOC93_15295 ENOG4105D38 putrescine abc transporter FOC93_15300 ENOG4105F38 ABC transporter, permease FOC93_15305 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC93_15310 ENOG4105C26 Dehydrogenase FOC93_15345 ENOG4105VFR signal peptidase FOC93_15350 ENOG4105DZ1 carboxypeptidase FOC93_15375 ENOG4105RHA ABC transporter, permease FOC93_15380 ENOG4108IUX (ABC) transporter FOC93_15415 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FOC93_15420 ENOG4105C7S Dehydrogenase FOC93_15440 ENOG41089UC methyltransferase, type 11 FOC93_15510 ENOG4105DK0 Indole-3-glycerol phosphate synthase FOC93_15520 ENOG4105DDQ anthranilate synthase FOC93_15530 ENOG4105CK7 Sodium proline symporter FOC93_15605 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOC93_15615 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC93_15620 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOC93_15640 ENOG4107TVC Glycosyl transferase, family 2 FOC93_15660 ENOG4105K64 Glycosyl transferase, family 2 FOC93_15680 ENOG4105EMS pseudouridine synthase FOC93_15685 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FOC93_15700 ENOG4105MIX Adenylate cyclase FOC93_15705 ENOG4108Z18 K06886 hemoglobin FOC93_15720 ENOG4105DPN Oligoendopeptidase f FOC93_15730 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC93_15740 ENOG4108ZCF integral membrane protein FOC93_15760 ENOG4105UQX Mate efflux family protein FOC93_15765 ENOG4108JQ7 (ABC) transporter FOC93_15775 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC93_15780 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC93_15795 ENOG4105C31 Tryptophanyl-tRNA synthetase FOC93_15810 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOC93_15815 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOC93_15840 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FOC93_15850 ENOG4108KP7 hydrolase FOC93_15860 ENOG41073B9 FOC93_15865 ENOG4107AYK membrAne FOC93_15875 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC93_15880 ENOG4105QNR S1 RNA binding domain protein FOC93_15900 ENOG4105BZU Histidine kinase FOC93_15905 ENOG4105CH6 catalase FOC93_15910 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC93_15915 ENOG4105CAQ asparagine synthetase FOC93_15930 ENOG4105C8Y Acetylornithine aminotransferase FOC93_15940 ENOG4105ERH Fumarylacetoacetate hydrolase FOC93_16040 ENOG4107QP3 malate synthase g FOC93_16050 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) FOC93_16055 ENOG4105C8Q Methyl-accepting chemotaxis FOC93_16060 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FOC93_16080 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC93_16095 ENOG41086D8 Transcriptional regulator FOC93_16100 ENOG4108AEY RNA polymerase sigma factor FOC93_16110 ENOG4107TVP HD domain protein FOC93_16115 ENOG4107RN3 metallophosphoesterase FOC93_16130 ENOG4108IJ6 ABC transporter FOC93_16135 ENOG4105ECW sulfate abc transporter FOC93_16140 ENOG4108I5D sulfate abc transporter FOC93_16145 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FOC93_16155 ENOG4105CEY Amp-dependent synthetase and ligase FOC93_16165 ENOG4105DF9 Lipoate-protein, ligase FOC93_16170 ENOG4108RQ5 Beta-lactamase domain-containing protein FOC93_16175 ENOG4106AXD FOC93_16205 ENOG4105ECB domain protein FOC93_16205 ENOG4105ECB domain protein FOC93_16220 ENOG4105NA0 Transcriptional regulator FOC93_16245 ENOG4105C1Q protoporphyrinogen oxidase FOC93_16250 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOC93_16260 ENOG4105BZ4 penicillin-binding protein FOC93_16265 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FOC93_16275 ENOG410905X membrane-flanked domain protein FOC93_16315 ENOG4105CKV Membrane FOC93_16320 ENOG410905X membrane-flanked domain protein FOC93_16355 ENOG4105K59 histidine triad (HIT) protein FOC93_16380 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOC93_16385 ENOG4105EEM helicase FOC93_16390 ENOG4105CNI cell division protein FtsW FOC93_16420 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOC93_16435 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC93_16445 ENOG4105F0F Oxalate decarboxylase FOC93_16465 ENOG4108MUZ hydrolase FOC93_16500 ENOG4105ED2 Beta-lactamase FOC93_16510 ENOG4106D4I domain protein FOC93_16515 ENOG4107VRP DNA repair exonuclease FOC93_16535 ENOG4107QHE Choloylglycine hydrolase FOC93_16545 ENOG4105D7V transposase FOC93_16585 ENOG4105BZU Histidine kinase FOC93_16590 ENOG4105BZU Histidine kinase FOC93_16595 ENOG4108MJI response regulator FOC93_16605 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC93_16615 ENOG4105WN5 stage II sporulation protein FOC93_16710 ENOG4105CMT Dihydroxyacetone kinase FOC93_16720 ENOG4105CMT Dihydroxyacetone kinase FOC93_16725 ENOG4108NIW Leucine export protein LeuE FOC93_16740 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOC93_16790 ENOG4105F6J Alpha beta hydrolase fold FOC93_16845 ENOG4105D9U N-acetyltransferase FOC93_16865 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC93_16885 ENOG4108Z86 Glutamine amidotransferase FOC93_16910 ENOG4105CDU Replicative dna helicase FOC93_16955 ENOG4107SCJ type I restriction enzyme EcoKI subunit R FOC93_16975 ENOG4108MRH transcriptional regulatory protein FOC93_16985 ENOG4105CSH Transporter FOC93_17040 ENOG4108IBT Inherit from COG: transposase FOC93_17100 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein FOC93_17115 ENOG4108JQ7 (ABC) transporter FOC93_17125 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC93_17170 ENOG4105DER m42 family FOC93_17190 ENOG4105CGU Enoyl-CoA hydratase FOC93_17215 ENOG4105CHH sulfate transporter FOC93_17230 ENOG4105CEY Amp-dependent synthetase and ligase FOC93_17235 ENOG4105D4P Coproporphyrinogen iii oxidase FOC93_17240 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOC93_17255 ENOG4108VX5 3-methyladenine DNA glycosylase FOC93_17265 ENOG4107FQX Alpha-acetolactate decarboxylase FOC93_17315 ENOG4105WH1 Two component transcriptional regulator luxr family FOC93_17320 ENOG4105BZU Histidine kinase FOC93_17335 ENOG4108UH6 UPF0754 membrane protein FOC93_17345 ENOG410839P FOC93_17360 ENOG4105CDA abc transporter atp-binding protein FOC93_17365 ENOG4105DRP amino acid AbC transporter FOC93_17375 ENOG4105BZ1 (ABC) transporter FOC93_17380 ENOG4105BZ1 (ABC) transporter FOC93_17385 ENOG4105C26 Dehydrogenase FOC93_17395 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOC93_17405 ENOG4105D5Q Arginine ornithine antiporter FOC93_17415 ENOG4105CH6 catalase FOC93_17420 ENOG4107RKG DJ-1/PfpI family FOC93_17435 ENOG4105E5W Transporter FOC93_17440 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOC93_17485 ENOG4105UBK short-chain dehydrogenase reductase FOC93_17490 ENOG4105CH7 arginosuccinase FOC93_17495 ENOG4108YXU transcriptional regulator AsnC family FOC93_17535 ENOG4106KNT transcriptional regulator FOC93_17545 ENOG4107RWR Sodium hydrogen exchanger FOC93_17550 ENOG4105CUB amino acid FOC93_17585 ENOG4107T5V SNARE associated Golgi FOC93_17620 ENOG4105WEF catalase FOC93_17650 ENOG4105C19 ABC transporter FOC93_17655 ENOG4107RBB ABC transporter, permease FOC93_17660 ENOG41069ER domain protein FOC93_17685 ENOG4105VZJ PTS System FOC93_17690 ENOG4105VCP PTS System FOC93_17695 ENOG4105EMD TRANSCRIPTIONal FOC93_17720 ENOG4108KGH TRANSCRIPTIONal FOC93_17730 ENOG41087NI Sulfite exporter TauE/SafE FOC93_17735 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FOC93_17745 ENOG4105VFE sira family FOC93_17750 ENOG4105VFE sira family FOC93_17755 ENOG4107TPS domain protein FOC93_17760 ENOG4105VFE sira family FOC93_17765 ENOG4105XTG Pfam:DUF156 FOC93_17770 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FOC93_17775 ENOG4108TCS Glutamyl endopeptidase FOC93_17785 ENOG4105ED1 spovr family FOC93_17790 ENOG4107Y03 Nitroreductase FOC93_17810 ENOG4108B31 Spore germination protein FOC93_17830 ENOG4105K63 Thioredoxin FOC93_17845 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC93_17855 ENOG4105C7N Xanthine uracil vitamin C permease FOC93_17865 ENOG4105C19 ABC transporter FOC93_17890 ENOG4108INS Transcriptional regulator FOC93_17940 ENOG4105DWF phosphomethylpyrimidine kinase FOC93_17945 ENOG4105D06 uba thif-type nad fad binding protein FOC93_17960 ENOG41080HI glycine oxidase FOC93_17965 ENOG4108VEU Thiamine monophosphate synthase FOC93_17975 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC93_17985 ENOG4105ETU transcriptional activator (TenA FOC93_18005 ENOG41080XQ Signal transduction protein with cbs domains FOC93_18135 ENOG4105C8U phosphate abc transporter FOC93_18140 ENOG4105CVA phosphate FOC93_18145 ENOG4105CE1 Ferrous iron transport protein b FOC93_18150 ENOG4105CE1 Ferrous iron transport protein b FOC93_18155 ENOG4105CE1 Ferrous iron transport protein b FOC93_18165 ENOG4108NHD germination protein FOC93_18180 ENOG4105E1V na solute symporter FOC93_18205 ENOG4105E2S oxidase) subunit II FOC93_18210 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOC93_18215 ENOG4105CCU oxidase (Subunit III) FOC93_18235 ENOG4105MA6 gCN5-related N-acetyltransferase FOC93_18250 ENOG4105C7N Xanthine uracil vitamin C permease FOC93_18255 ENOG4105C85 amino acid FOC93_18275 ENOG4105DUX Transporter FOC93_18290 ENOG4107D63 FOC93_18295 ENOG4105VZ8 Transcriptional regulator FOC93_18300 ENOG41069ER domain protein FOC93_18305 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC93_18310 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FOC93_18340 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) FOC93_18380 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOC93_18385 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOC93_18390 ENOG4105CNN ABC, transporter FOC93_18395 ENOG4105C2J ABC transporter FOC93_18405 ENOG4108RVA ribokinase FOC93_18410 ENOG4105ETE Transcriptional regulator (LacI family FOC93_18415 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC93_18420 ENOG41067TZ transcriptional regulator, MarR family FOC93_18425 ENOG4105CXY transporter FOC93_18435 ENOG41068KF Universal stress protein FOC93_18440 ENOG4105CHH sulfate transporter FOC93_18450 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC93_18455 ENOG4105BZU Histidine kinase FOC93_18460 ENOG4105NAE bifunctional deaminase-reductase domain protein FOC93_18465 ENOG4105D29 Helix-turn-helix type 11 domain protein FOC93_18475 ENOG4105GFR rna polymerase sigma factor FOC93_18490 ENOG4108IQI permease FOC93_18495 ENOG4105DRP amino acid AbC transporter FOC93_18500 ENOG4105EAD ABC transporter FOC93_18505 ENOG4105CT1 (ABC) transporter FOC93_18510 ENOG4105CDA abc transporter atp-binding protein FOC93_18520 ENOG4105CRN Aminoglycoside phosphotransferase FOC93_18525 ENOG4105E1K spore germination protein FOC93_18540 ENOG4105CG3 alpha amylase, catalytic region FOC93_18545 ENOG4105C5Y PTS System FOC93_18550 ENOG4107414 GntR family transcriptional regulator FOC93_18555 ENOG4105D5Q Arginine ornithine antiporter FOC93_18565 ENOG4105BZU Histidine kinase FOC93_18575 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOC93_18580 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FOC93_18585 ENOG4107T89 von Willebrand factor, type A FOC93_18595 ENOG4105EXW epimerase dehydratase FOC93_18600 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FOC93_18605 ENOG4105DMQ Methyltransferase FOC93_18610 ENOG4105E0A ABC, transporter FOC93_18615 ENOG4108IHU transport system permease protein FOC93_18620 ENOG4105DQ5 transport system permease protein FOC93_18625 ENOG4108MES Periplasmic binding protein FOC93_18630 ENOG4105DUX Transporter FOC93_18645 ENOG4105DAA L-lactate FOC93_18650 ENOG4108IJ0 Aspartate ammonia-lyase FOC93_18655 ENOG4105C37 (CBS) domain FOC93_18660 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOC93_18665 ENOG4105D9N nucleoside FOC93_18670 ENOG4108KGH TRANSCRIPTIONal FOC93_18675 ENOG41073R8 VanW family FOC93_18710 ENOG4105DAP Nicotinate phosphoribosyltransferase FOC93_18715 ENOG4105C59 p-type ATPase FOC93_18730 ENOG4105CUB amino acid FOC93_18750 ENOG4108JB9 formate dehydrogenase FOC93_18755 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOC93_18760 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOC93_18765 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC93_18770 ENOG4105BZU Histidine kinase FOC93_18780 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOC93_18785 ENOG4108UZ3 Transporter FOC93_18795 ENOG4105C6K Malic enzyme FOC93_18805 ENOG4108MRH transcriptional regulatory protein FOC93_18830 ENOG41062D9 Histidine kinase FOC93_18835 ENOG4108STX response regulator FOC93_18840 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOC93_18845 ENOG4105BZ7 extracellular solute-binding protein family 1 FOC93_18850 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FOC93_18855 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOC93_18860 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOC93_18865 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOC93_18890 ENOG4105D4T Citrate transporter FOC93_18895 ENOG4108V9W transcriptional regulatory protein FOC93_18900 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOC93_18910 ENOG4105DZ6 Band 7 protein FOC93_18925 ENOG4105C94 Transporter FOC93_18945 ENOG4105CYN Serine protein kinase FOC93_18955 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOC93_18965 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOC93_18975 ENOG4108R9S DSBA oxidoreductase FOC93_18980 ENOG4108JQC penicillin-binding protein 1A FOC93_19100 ENOG4105G5W regulator Fur family FOC93_19105 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOC93_19125 ENOG4108IUW ABC transporter FOC93_19135 ENOG4105CBC glutamate synthase FOC93_19140 ENOG4107NBY Membrane FOC93_19145 ENOG4105BZ1 (ABC) transporter FOC93_19165 ENOG4106BXE FOC93_19170 ENOG4105CEN a g-specific adenine glycosylase FOC93_19175 ENOG41067AE Membrane-bound metal-dependent hydrolase FOC93_19205 ENOG4105ECP epimerase FOC93_19210 ENOG4105CI2 imidazolone-5-propionate hydrolase FOC93_19225 ENOG4108QBV Monogalactosyldiacylglycerol synthase FOC93_19230 ENOG4105F1A Pyruvate formate-lyase FOC93_19250 ENOG4105C3I Nad-dependent epimerase dehydratase FOC93_19255 ENOG4107QQG Dehydrogenase FOC93_19260 ENOG4105CKK Glycosyl transferase, family 2 FOC93_19275 ENOG4108A04 Beta-lactamase FOC93_19315 ENOG4108IQI permease FOC93_19325 ENOG4108JUB Transcriptional regulator FOC93_19335 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC93_19340 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC93_19375 ENOG4105UPD Calcium Proton FOC93_19380 ENOG410606W general stress protein FOC93_19395 ENOG4107ZTW SNARE associated Golgi FOC93_19415 ENOG4108IPJ Membrane FOC93_19420 ENOG4105C59 p-type ATPase FOC93_19425 ENOG4107U9T Pfam:Ribonuclease_BN FOC93_19435 ENOG4105KJF protein tyrosine phosphatase FOC93_19455 ENOG4108TTB tellurium resistance protein FOC93_19460 ENOG4107TS3 membrane protein, TerC FOC93_19465 ENOG4106FN3 tellurium resistance protein FOC93_19470 ENOG4106FN3 tellurium resistance protein FOC93_19475 ENOG4108N0M stress protein FOC93_19490 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FOC93_19505 ENOG4105DEU major facilitator superfamily FOC93_19520 ENOG41062JF Transcriptional regulator FOC93_19560 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOC93_19580 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FOC93_19595 ENOG4105C9U ATP-dependent DNA helicase RecQ FOC93_19610 ENOG4105CI1 PTS System FOC93_19620 ENOG4105DNP FAD linked oxidase domain protein FOC93_19630 ENOG4108W63 CRP FNR family transcriptional regulator FOC93_19635 ENOG4105C5B carbamate kinase FOC93_19645 ENOG4105DBV ornithine carbamoyltransferase FOC93_19660 ENOG4105C8Q Methyl-accepting chemotaxis FOC93_19670 ENOG4105EAB amino acid AbC transporter FOC93_19675 ENOG4105E5Q amino acid AbC transporter FOC93_19690 ENOG4105D2S major facilitator superfamily FOC93_19695 ENOG410756H nucleotidyltransferase FOC93_19715 ENOG4105BZU Histidine kinase FOC93_19730 ENOG4106UIA FOC93_19735 ENOG4106UIA FOC93_19755 ENOG4108V5C ABC transporter FOC93_19760 ENOG4105DQ5 transport system permease protein FOC93_19765 ENOG4105EHG Permease protein FOC93_19785 ENOG4105D3R alkyl hydroperoxide reductase FOC93_19805 ENOG4105DFD Na H antiporter FOC93_19815 ENOG4105DTQ mandelate racemase muconate lactonizing FOC93_19830 ENOG4108W15 Protein of unknown function (DUF1456) FOC93_19850 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOC93_19855 ENOG4105D9N nucleoside FOC93_19885 ENOG4105KPY Small multidrug resistance protein FOC93_19890 ENOG4105C26 Dehydrogenase FOC93_19900 ENOG4108JPW Aminotransferase FOC93_19905 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOC93_19910 ENOG4105CBD Diacylglycerol kinase FOC93_19930 ENOG4107I77 yiaA/B two helix domain FOC93_19935 ENOG410834F Transcriptional regulator FOC93_19955 ENOG4105D01 (LipO)protein FOC93_19960 ENOG4108UMI ABC transporter, permease FOC93_19965 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC93_19970 ENOG4108W2Y isochorismatase FOC93_19990 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FOC93_19995 ENOG4105C4R Atp-dependent dna helicase FOC93_20020 ENOG4105C12 Phosphoribosylglycinamide synthetase FOC93_20030 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOC93_20055 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FOC93_20065 ENOG4105C83 adenylosuccinate lyase FOC93_20070 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOC93_20075 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOC93_20100 ENOG4105SX7 Transporter FOC93_20120 ENOG4108SHN Glycosyl transferase, family 2 FOC93_20130 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) FOC93_20170 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC93_20215 ENOG4107ZXU DSBA oxidoreductase FOC93_20240 ENOG4105BZU Histidine kinase FOC93_20250 ENOG4105C7N Xanthine uracil vitamin C permease FOC93_20270 ENOG4108TYN CAAX amino terminal protease family protein FOC93_20285 ENOG4105C5H ABC transporter FOC93_20290 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC93_20295 ENOG410801F ribosomal-protein-alanine acetyltransferase FOC93_20300 ENOG41072GX Peptidase M22 Glycoprotease FOC93_20305 ENOG4105K8N protein family UPF0079, ATPase FOC93_20410 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FOC93_20420 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOC93_20425 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FOC93_20450 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOC93_20455 ENOG4105CPF Cell wall formation (By similarity) FOC93_20460 ENOG4108SC4 )-transporter FOC93_20465 ENOG4105CUB amino acid FOC93_20475 ENOG4105ERH Fumarylacetoacetate hydrolase FOC93_20480 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FOC93_20510 ENOG410667J hydrolase FOC93_20515 ENOG4108JQ7 (ABC) transporter FOC93_20520 ENOG4105C3U ABC transporter FOC93_20525 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC93_20535 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FOC93_20545 ENOG4105C5H ABC transporter FOC93_20565 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FOC93_20580 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOC93_20600 ENOG4105F6E Acyl-transferase FOC93_20620 ENOG4105EGI Transcriptional regulator FOC93_20630 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FOC93_20635 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOC93_20640 ENOG4105E0C molybdate abc transporter FOC93_20660 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC93_20665 ENOG4108J59 Extracellular solute-binding protein, family 5 FOC93_20695 ENOG4108JQ7 (ABC) transporter FOC93_20700 ENOG4105C3U ABC transporter FOC93_20705 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOC93_20710 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOC93_20725 ENOG4105C2C drug resistance transporter, Bcr CflA FOC93_20740 ENOG4105IQ5 FAD linked oxidase domain protein FOC93_20750 ENOG4105CB2 alcohol dehydrogenase FOC93_20755 ENOG4105D01 (LipO)protein FOC93_20760 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC93_20765 ENOG4108UMI ABC transporter, permease FOC93_20770 ENOG4108PSK reductase FOC93_20795 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FOC93_20810 ENOG4107U5W ybbr family FOC93_20815 ENOG4105C8B TIGR00159 family FOC93_20895 ENOG4108NMV polysaccharide deacetylase FOC93_20910 ENOG4105D1F ATP-binding protein FOC93_20935 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FOC93_20940 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOC93_20945 ENOG4108JJB ABC transporter FOC93_20950 ENOG4108JJB ABC transporter FOC93_20985 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOC93_20995 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOC93_21125 ENOG4105XPM ribosomal protein FOC93_21140 ENOG4107Y49 methyltransferase FOC93_21165 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOC93_21180 ENOG4105QIV RNA polymerase FOC93_21185 ENOG4105M0M Tetracycline resistance protein FOC93_21190 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOC93_21205 ENOG4105D7W serine acetyltransferase FOC93_21220 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FOC93_21225 ENOG4105CTP PilT protein domain protein FOC93_21235 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOC93_21250 ENOG4108Z0C Uvrb UvrC protein FOC93_21340 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOC93_21350 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOC93_21355 ENOG4105KRF dihydroneopterin aldolase FOC93_21360 ENOG4105EEI dihydropteroate synthase FOC93_21365 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FOC93_21370 ENOG4105DDQ anthranilate synthase FOC93_21375 ENOG4105CRQ synthase (Component I) FOC93_21380 ENOG4105C6T cysteine synthase FOC93_21395 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOC93_21400 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC93_21405 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FOC93_21425 ENOG41060GV RNA binding s1 domain protein FOC93_21440 ENOG4105VYY sporulation protein yabp FOC93_21445 ENOG41082I2 s4 domain protein FOC93_21450 ENOG4108IY2 MazG family FOC93_21460 ENOG4108M14 stage v sporulation protein t FOC93_21465 ENOG4108JA2 transcriptioN-repair coupling factor FOC93_21475 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FOC93_21495 ENOG4105KME endoribonuclease L-psp FOC93_21500 ENOG4105DFT pur operon repressor FOC93_21515 ENOG4105W42 Veg protein FOC93_21520 ENOG4105XFA sporulation peptidase YabG FOC93_21530 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FOC93_21535 ENOG4105F8V Hydrolase, tatD family FOC93_21540 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FOC93_21545 ENOG4105KRN Transcriptional regulator, abrb family FOC93_21550 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOC93_21560 ENOG41060K3 Methyltransferase FOC93_21570 ENOG4105MA4 psp1 domain protein FOC93_21575 ENOG4105FA2 dna polymerase iii FOC93_21585 ENOG4105CXN decarboxylase FOC93_21620 ENOG41067KS pro-sigma K processing FOC93_21640 ENOG4105C6E dna polymerase iii FOC93_21650 ENOG4108Z6B deaminase FOC93_21655 ENOG4105GTG Isochorismatase FOC93_21665 ENOG4105ZMH deoxynucleoside kinase FOC93_21700 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOC93_21735 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOC93_21750 ENOG410848D S4 domain protein YaaA FOC93_21755 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOC93_21775 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC93_21785 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FOC93_21805 ENOG4107QJE Chromosome Partitioning Protein FOC93_21810 ENOG4105FA0 parb-like partition protein FOC93_21815 ENOG4108ZDA Sporulation protein YyaC FOC93_21820 ENOG4105D8X mechanosensitive ion channel FOC93_21825 ENOG4105VDK protein, conserved in bacteria FOC93_21830 ENOG4105C3G gtp-binding protein FOC93_21840 ENOG4108UUM single-stranded DNA-binding protein FOC93_21850 ENOG4108XMW Membrane FOC93_21855 ENOG4105BZR domain protein FOC93_21865 ENOG4105CDU Replicative dna helicase FOC93_21870 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FOC93_21895 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC93_21900 ENOG4105BZU Histidine kinase FOC93_21915 ENOG4105Q2H domain protein FOC93_21920 ENOG4105C0H protease FOC93_21935 ENOG4105BZU Histidine kinase FOC93_21955 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) FOC93_21960 ENOG4105C1J atp-dependent rna helicase FOC93_21970 ENOG4108UT2 hemolysin iii FOC93_21975 ENOG4105CMR udp-glucose 4-epimerase FOC93_21980 ENOG4105IW1 AmiS UreI transporter FOC93_21990 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC93_22005 ENOG4107RGD Major Facilitator superfamily FOC93_22010 ENOG4108HRK Histidine kinase FOC93_22015 ENOG4108NEV two component transcriptional regulator, LytTR family FOC93_22030 ENOG4106F5Q Membrane FOC93_22035 ENOG4105E0X reductase FOC93_22045 ENOG41067SE Tetr family transcriptional regulator FOC93_22050 ENOG4105C5H ABC transporter FOC93_22055 ENOG4105CKK Glycosyl transferase, family 2 FOC93_22060 ENOG4105EJV Membrane FOC93_22070 ENOG4105K64 Glycosyl transferase, family 2 FOC93_22085 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) FOC93_22090 ENOG4108S4H thioesterase Superfamily protein FOC93_22100 ENOG4106YBV Methyl-accepting chemotaxis FOC93_22105 ENOG4105EN6 Membrane FOC93_22115 ENOG4105CG5 Glycosyl transferase (Group 1 FOC93_22125 ENOG41079KZ Major Facilitator Superfamily FOC93_22130 ENOG4105DY9 regulatoR FOC93_22135 ENOG4105D22 carbon starvation protein FOC93_22140 ENOG4105VCD cytoplasmic protein FOC93_22145 ENOG4105BZU Histidine kinase FOC93_22150 ENOG4105DWF phosphomethylpyrimidine kinase FOC93_22155 ENOG4105BZU Histidine kinase FOC93_22160 ENOG4105WH1 Two component transcriptional regulator luxr family FOC93_22170 ENOG4108Y4K DNA-binding transcriptional activator FOC93_22195 ENOG4105D6E homoserine dehydrogenase FOC93_22210 ENOG41090WU lipolytic protein G-D-S-L family FOC93_22215 ENOG4105CJ1 ABC, transporter FOC93_22220 ENOG4108TU7 Inherit from COG: (ABC) transporter FOC93_22230 ENOG4105VCH membrane FOC93_22235 ENOG410667J hydrolase FOC93_22245 ENOG4107SVH Potassium channel protein FOC93_22265 ENOG4108VKI Cell wall hydrolase FOC93_22280 ENOG4108IJ2 phosphate acetyltransferase FOC93_22285 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) FOC93_22290 ENOG4108VCI transcription factor, rsfa family FOC93_22300 ENOG4105DQ5 transport system permease protein FOC93_22305 ENOG4105EHG Permease protein FOC93_22310 ENOG4105E0A ABC, transporter FOC93_22315 ENOG4108MES Periplasmic binding protein FOC93_22320 ENOG4105DCI Phosphohydrolase FOC93_22325 ENOG41069HH 4-oxalocrotonate tautomerase FOC93_22330 ENOG4108Z4T Peptidase M50 FOC93_22335 ENOG4108XFG YwhD family FOC93_22340 ENOG4105BZ4 penicillin-binding protein FOC93_22345 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC93_22350 ENOG4107SWG transcriptional regulator MERR family FOC93_22355 ENOG4105DXB Major Facilitator superfamily FOC93_22365 ENOG4105CYW agmatinase FOC93_22385 ENOG410684U Domain of unknown function (DUF1934) FOC93_22395 ENOG4105JVQ RNA Polymerase FOC93_22415 ENOG4105IIU Aminopeptidase FOC93_22425 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FOC93_22430 ENOG4108M15 ABC transporter FOC93_22435 ENOG4105KCT ABC transporter FOC93_22440 ENOG4105BZU Histidine kinase FOC93_22450 ENOG4105D4Y metalloprotease FOC93_22465 ENOG4105BZU Histidine kinase FOC93_22480 ENOG4105DF6 Fe-S oxidoreductase FOC93_22490 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FOC93_22495 ENOG4105C1G acyl-Coa dehydrogenase FOC93_22500 ENOG4105C1G acyl-Coa dehydrogenase FOC93_22515 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FOC93_22535 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FOC93_22540 ENOG4105CBT Fructose-1,6-bisphosphatase FOC93_22545 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FOC93_22555 ENOG4107104 thymidine kinase FOC93_22560 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FOC93_22565 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FOC93_22570 ENOG4108ZXQ stage ii sporulation protein r FOC93_22580 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FOC93_22595 ENOG4107XC4 flavin reductase domain protein, FMN-binding FOC93_22600 ENOG4108VGI doxx family FOC93_22615 ENOG4108YZG isomerase FOC93_22620 ENOG4108UIC UPF0340 protein FOC93_22625 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FOC93_22645 ENOG41062M3 atp synthase FOC93_22650 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FOC93_22700 ENOG4105BZU Histidine kinase FOC93_22705 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC93_22715 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FOC93_22720 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC93_22745 ENOG4105D65 subunit l FOC93_22750 ENOG4105C8S subunit m FOC93_22755 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FOC93_22760 ENOG4106778 Protein of unknown function (DUF1146) FOC93_22780 ENOG4105DY9 regulatoR FOC93_22795 ENOG4105FRN stage II sporulation protein FOC93_22805 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FOC93_22820 ENOG4107YJ4 chain length determinant protein FOC93_22825 ENOG4105HTX biosynthesis protein FOC93_22830 ENOG4107YJ4 chain length determinant protein FOC93_22835 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FOC93_22840 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC93_22845 ENOG4105D3Q Sugar transferase FOC93_22855 ENOG4108PTS heparinase ii FOC93_22865 ENOG4107U9V N5-(Carboxyethyl)ornithine synthase FOC93_22900 ENOG4107EF8 Glycosyl transferase (Group 1 FOC93_22905 ENOG4105CPK Glycosyl transferase (Group 1 FOC93_22915 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOC93_22920 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOC93_22930 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOC93_22935 ENOG4108KGH TRANSCRIPTIONal FOC93_22945 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC93_22950 ENOG4105BZU Histidine kinase FOC93_22965 ENOG4105CXY transporter FOC93_22985 ENOG4105C19 ABC transporter FOC93_22990 ENOG4107RBB ABC transporter, permease FOC93_23000 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC93_23030 ENOG4105C0D helicase FOC93_23035 ENOG4105KBK Zinc finger, swim domain protein FOC93_23060 ENOG41069ER domain protein FOC93_23065 ENOG4105C94 Transporter FOC93_23070 ENOG4107R8N Glycosyl transferase, family 2 FOC93_23095 ENOG4105E0M Sulfatase FOC93_23105 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FOC93_23115 ENOG4105DAA L-lactate FOC93_23150 ENOG4107RSM transcriptional regulator FOC93_23155 ENOG4105ECB domain protein FOC93_23175 ENOG4105VZJ PTS System FOC93_23185 ENOG4105VCP PTS System FOC93_23195 ENOG4105CK1 PTS System FOC93_23200 ENOG4105VCP PTS System FOC93_23205 ENOG4105F8D glycoside hydrolase family 4 FOC93_23225 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOC93_23235 ENOG4105ESV Glycosyl transferase, family 4 FOC93_23245 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOC93_23250 ENOG4108KGH TRANSCRIPTIONal FOC93_23255 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOC93_23265 ENOG4105KVH Transcriptional regulator FOC93_23280 ENOG41081UC Inherit from COG: Competence protein FOC93_23285 ENOG4105VEQ Cold shock protein FOC93_23290 ENOG4105MS2 ribosomal subunit Interface protein FOC93_23320 ENOG4108RDQ ABC transporter FOC93_23345 ENOG4105CAK Cell division ATP-binding protein ftsE FOC93_23350 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOC93_23355 ENOG4105CN1 protease FOC93_23365 ENOG4105BZ1 (ABC) transporter FOC93_23380 ENOG4108WS4 fmn reductase FOC93_23390 ENOG4105DUM transcriptional regulator, lysR family FOC93_23410 ENOG4107TXC Transcriptional regulator FOC93_23425 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FOC93_23430 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOC93_23440 ENOG41086DT Membrane protein of unknown function FOC93_23460 ENOG4108S4C acetyltransferase FOC93_23470 ENOG4105C3M thioredoxin reductase FOC93_23480 ENOG4108Z4K mutator MutT protein FOC93_23490 ENOG4105CHW UPF0052 protein FOC93_23500 ENOG4105KRI phosphocarrier protein (HPr FOC93_23510 ENOG4108QY0 Membrane FOC93_23525 ENOG4105CZ3 stage V sporulation protein ad FOC93_23530 ENOG41090VF Stage v sporulation protein ac FOC93_23550 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC93_23600 ENOG41067MG lrgb family FOC93_23605 ENOG4105XZU Preprotein translocase, subunit SecG FOC93_23615 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOC93_23665 ENOG4105C19 ABC transporter FOC93_23670 ENOG4107RBB ABC transporter, permease FOC93_23710 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC93_23725 ENOG4105CM4 permease protein FOC93_23730 ENOG4108IPW abc transporter atp-binding protein FOC93_23745 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) FOC93_23750 ENOG4108V2W Carbonate dehydratase FOC93_23775 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC93_23780 ENOG4105C5H ABC transporter FOC93_23800 ENOG4105WMR Protein CrcB homolog FOC93_23805 ENOG4105WMR Protein CrcB homolog FOC93_23815 ENOG4105C8Q Methyl-accepting chemotaxis FOC93_23825 ENOG4105D4A Cell wall formation (By similarity) FOC93_23830 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOC93_23845 ENOG4105KVH Transcriptional regulator FOC93_23850 ENOG4105F27 Major Facilitator FOC93_23855 ENOG4105CV8 reductase FOC93_23870 ENOG4108RYK Nad-dependent epimerase dehydratase FOC93_23885 ENOG4105D9N nucleoside FOC93_23890 ENOG4105D9N nucleoside FOC93_23895 ENOG4105DHF Membrane FOC93_23900 ENOG41090A1 ferritin FOC93_23910 ENOG4108URH decarboxylase FOC93_23925 ENOG4108RMU ferritin dps family protein FOC93_23935 ENOG4105NCW Trka-c domain protein FOC93_23940 ENOG4107S91 Sodium hydrogen exchanger FOC93_23945 ENOG4107T5V SNARE associated Golgi FOC93_23970 ENOG4105D4Y metalloprotease FOC93_23975 ENOG4105VG1 fes assembly suf system protein FOC93_23980 ENOG4105C8Q Methyl-accepting chemotaxis FOC93_23995 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FOC93_24010 ENOG4105BZU Histidine kinase FOC93_24015 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC93_24020 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOC93_24030 ENOG4107ZTW SNARE associated Golgi FOC93_24065 ENOG4107AYK membrAne FOC93_24075 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOC93_24090 ENOG4107R7I amino acid FOC93_24095 ENOG4108SUT Major Facilitator Superfamily FOC93_24110 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOC93_24130 ENOG4105DZ1 carboxypeptidase FOC93_24145 ENOG4105CHU acetyl-coa acetyltransferase FOC93_24150 ENOG4105C1G acyl-Coa dehydrogenase FOC93_24155 ENOG4108W8B Beta-lactamase domain protein FOC93_24180 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOC93_24200 ENOG41080E8 Transcriptional regulator, Spx MgsR family FOC93_24225 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC93_24230 ENOG4108UMI ABC transporter, permease FOC93_24235 ENOG4105D01 (LipO)protein FOC93_24240 ENOG4105D01 (LipO)protein FOC93_24245 ENOG4105C3K feS assembly ATPase SufC FOC93_24250 ENOG4105JRK feS assembly protein SufD FOC93_24255 ENOG4105C9B Cysteine desulfurase FOC93_24260 ENOG4108UNV SUF system FeS assembly protein, NifU family FOC93_24265 ENOG4105DIW FeS assembly protein SUFB FOC93_24270 ENOG4107R8B 5'-nucleotidase FOC93_24275 ENOG4105KZD Domain of unknown function (DUF1805) FOC93_24280 ENOG4108YTE sporulation protein YunB FOC93_24285 ENOG4105FAA peptidase M23 FOC93_24310 ENOG41090T1 Membrane FOC93_24315 ENOG4107TXC Transcriptional regulator FOC93_24320 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FOC93_24325 ENOG4105MMD transcriptional regulator FOC93_24340 ENOG4105CBT Fructose-1,6-bisphosphatase FOC93_24355 ENOG4105D4U had-superfamily hydrolase, subfamily iia FOC93_24360 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOC93_24370 ENOG4105DAX Pfam:DUF2983 FOC93_24390 ENOG4108W5N phosphatidylglycerophosphatase a FOC93_24405 ENOG41083MR nifu domain-containing protein FOC93_24440 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOC93_24445 ENOG4105C4B ABC transporter, permease FOC93_24450 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FOC93_24475 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOC93_24490 ENOG4105EWC Purine nucleoside phosphorylase FOC93_24520 ENOG4105CEP NADH dehydrogenase FOC93_24535 ENOG41069ER domain protein FOC93_24555 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOC93_24570 ENOG4105KA0 thioesterase Superfamily protein FOC93_24590 ENOG4107R3E Citrate transporter FOC93_24600 ENOG4105Y38 Kinase-associated protein B FOC93_24615 ENOG4105C87 Aminotransferase class I and II FOC93_24625 ENOG4108MUZ hydrolase FOC93_24630 ENOG4105C5I Dehydrogenase FOC93_24635 ENOG4108ZB6 transcriptional regulator AsnC family FOC93_24640 ENOG4105CHM Aminotransferase FOC93_24650 ENOG4105WG9 Conserved Protein FOC93_24665 ENOG4107PBV potassium channel FOC93_24670 ENOG4105KT7 mgtC SapB transporter FOC93_24705 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOC93_24820 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FOC93_24855 ENOG4105VEQ Cold shock protein FOC93_24865 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOC93_24870 ENOG4105E4F Isochorismate synthase FOC93_24880 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FOC93_24885 ENOG4108IPT Naphthoate synthase FOC93_24895 ENOG4105DTQ mandelate racemase muconate lactonizing FOC93_24915 ENOG41069H0 dihydroorotase EC 3.5.2.3 FOC93_24940 ENOG4105C6Z Gluconate FOC93_24990 ENOG41082BM Transcriptional regulator, arsr family FOC93_25010 ENOG41086D8 Transcriptional regulator FOC93_25015 ENOG4105C19 ABC transporter FOC93_25030 ENOG4107ZTW SNARE associated Golgi FOC93_25060 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FOC93_25065 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOC93_25090 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOC93_25095 ENOG4105BZU Histidine kinase FOC93_25125 ENOG41087YS Phage shock protein A FOC93_25160 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOC93_25165 ENOG4105C4M (Ubiquinol oxidase) subunit I FOC93_25170 ENOG4108V2W Carbonate dehydratase FOC93_25235 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOC93_25245 ENOG4105D2X ABC transporter substrate-binding protein FOC93_25270 ENOG4107T7U Sulfatase FOC93_25275 ENOG4107S9D Alpha beta hydrolase FOC93_25280 ENOG4105BZU Histidine kinase FOC93_25285 ENOG4105BZU Histidine kinase FOC93_25325 ENOG4108MK9 spermidine N(1)-acetyltransferase FOC93_25335 ENOG4105EPU Molybdenum cofactor synthesis domain protein FOC93_25345 ENOG4105BZF Glycosyl transferase (Group 1 FOC93_25350 ENOG4105YVM Phosphoesterase, PA-phosphatase related FOC93_25355 ENOG4108Z0R Transferase FOC93_25360 ENOG4105E8V Alpha Beta Hydrolase Fold protein FOC93_25385 ENOG4105DA5 (ABC) transporter FOC93_25395 ENOG4105N5T Radical SAM Protein FOC93_25415 ENOG4105C19 ABC transporter FOC93_25430 ENOG4105NCW Trka-c domain protein FOC93_25435 ENOG4107S91 Sodium hydrogen exchanger FOC93_25440 ENOG410605W Major Facilitator FOC93_25445 ENOG4105C8T Leucyl-tRNA synthetase FOC93_25475 ENOG4108B31 Spore germination protein FOC93_25485 ENOG4105DWV Homoserine O-trans-acetylase FOC93_25495 ENOG41085GJ domain protein FOC93_25515 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOC93_25520 ENOG4105D06 uba thif-type nad fad binding protein FOC93_25530 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOC93_25535 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FOC93_25540 ENOG4108ZAF Molybdopterin FOC93_25555 ENOG4105CSC Glucose uptake protein FOC93_25560 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOC93_25565 ENOG4108VJ1 Transcriptional regulator (CarD family FOC93_25600 ENOG4105CBX hi0933 family FOC93_25615 ENOG4105YW5 deoR family transcriptional regulator FOC93_25620 ENOG4107QSE Dipeptidase FOC93_25630 ENOG4108IUM Glycogen debranching enzyme FOC93_25635 ENOG4108V15 phosphotransferase enzyme family FOC93_25650 ENOG4105C8F Beta-lactamase domain protein FOC93_25680 ENOG4108VDD TRNA binding domain protein FOC93_25690 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FOC93_25725 ENOG4105C88 aminopeptidase FOC93_25745 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOC93_25750 ENOG4105ETE Transcriptional regulator (LacI family FOC93_25770 ENOG4105EP9 oxidoreductase FOC93_25775 ENOG4107SNB ankyrin repeat protein YahD FOC93_25780 ENOG4105BZU Histidine kinase FOC93_25785 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC93_25800 ENOG4105DGU Histone deacetylase FOC93_25805 ENOG4105W87 Cbs domain FOC93_25810 ENOG4105F1V Acetoin utilization protein FOC93_25820 ENOG4108UW5 maltose o-acetyltransferase FOC93_25830 ENOG4105EMN RNA polymerase sigma factor FOC93_25985 ENOG4105C28 cystathionine FOC93_25995 ENOG4105U5Y Transcriptional regulator FOC93_26005 ENOG4105RQF LysR family Transcriptional regulator FOC93_26030 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOC93_26040 ENOG4105EFZ amidohydrolase FOC93_26055 ENOG4105KBJ sporulation protein ytfj FOC93_26060 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FOC93_26070 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FOC93_26090 ENOG4108JYZ YitT family FOC93_26125 ENOG4107YZX Universal stress protein FOC93_26145 ENOG41082W1 Cupin 2, conserved barrel domain protein FOC93_26185 ENOG4105DC7 peptidase M24 FOC93_26190 ENOG4105E8R UPF0173 metal-dependent hydrolase FOC93_26215 ENOG4105SFS phosphoesterase RecJ domain protein FOC93_26225 ENOG4105VV2 FOC93_26230 ENOG4105C0B DNA polymerase III (alpha subunit) FOC93_26235 ENOG4105C6K Malic enzyme FOC93_26240 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOC93_26265 ENOG4105FS0 cytoplasmic membrane protein FOC93_26270 ENOG4108REF Sporulation integral membrane protein ytvi FOC93_26280 ENOG4105BZN citrate synthase FOC93_26285 ENOG4108HMX isocitrate dehydrogenase (NADP) FOC93_26305 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC93_26310 ENOG4105BZU Histidine kinase FOC93_26315 ENOG4105C2M dna polymerase I FOC93_26320 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FOC93_26330 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOC93_26335 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOC93_26365 ENOG4108TDW sporulation protein YtxC FOC93_26370 ENOG4105C22 threonyL-tRNA synthetase FOC93_26375 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FOC93_26395 ENOG4105CN9 Peptidase m42 family protein FOC93_26400 ENOG4108JGH Tetr family transcriptional regulator FOC93_26405 ENOG4105CW7 secretion protein, HlyD family FOC93_26410 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOC93_26440 ENOG4108RWN rrna methyltransferase FOC93_26450 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FOC93_26455 ENOG4105C5S asparaginyl-tRNA synthetase FOC93_26475 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FOC93_26490 ENOG4105DCG PHP domain protein FOC93_26500 ENOG4105FE9 pseudouridine synthase FOC93_26510 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FOC93_26520 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FOC93_26535 ENOG4105E0A ABC, transporter FOC93_26540 ENOG4105KFN sortase, SrtB family FOC93_26550 ENOG4105DR4 Methyltransferase FOC93_26565 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOC93_26630 ENOG4105CEY Amp-dependent synthetase and ligase FOC93_26635 ENOG4107Z3H Transcriptional regulator, TetR family FOC93_26640 ENOG41060WC Enoyl-CoA hydratase FOC93_26645 ENOG4105BZJ Electron transfer flavoprotein FOC93_26650 ENOG4105C10 Electron transfer flavoprotein FOC93_26655 ENOG4105K63 Thioredoxin FOC93_26660 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOC93_26670 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FOC93_26680 ENOG4105E33 succinate dehydrogenase FOC93_26690 ENOG4108VXD carboxy-peptidase FOC93_26695 ENOG4105E14 MotA TolQ exbB proton channel FOC93_26700 ENOG4105ER2 Ompa motb domain protein FOC93_26705 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FOC93_26710 ENOG4108IUX (ABC) transporter FOC93_26715 ENOG4105RHA ABC transporter, permease FOC93_26720 ENOG4108Z40 Transcriptional regulator FOC93_26725 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOC93_26735 ENOG4108JCI Transcriptional regulator FOC93_26740 ENOG41067S9 phage shock protein C, PspC FOC93_26745 ENOG4105DZC cytosine deaminase FOC93_26755 ENOG4105PFC Transcriptional regulator FOC93_26770 ENOG4108XJQ germination protein FOC93_26785 ENOG4105M59 Phosphodiesterase, mj0936 family FOC93_26805 ENOG4108QCI YvbH-like oligomerisation region FOC93_26830 ENOG4108IUQ atp-dependent protease FOC93_26850 ENOG4105K56 Transcriptional regulator FOC93_26875 ENOG4105D52 delta-aminolevulinic acid dehydratase FOC93_26885 ENOG41068KH stage VI sporulation protein D FOC93_26895 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FOC93_26900 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOC93_26920 ENOG4105DFF Rod shape-determining protein mreb FOC93_26940 ENOG4107QMS site-determining protein FOC93_26955 ENOG4105C03 ribonuclease FOC93_26965 ENOG4105X36 (ribosomal) protein FOC93_26980 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FOC93_26990 ENOG4105EWM Histidine kinase FOC93_26995 ENOG4105C19 ABC transporter FOC93_27010 ENOG4105CQC Prephenate dehydratase FOC93_27015 ENOG4108RPX mosc domain containing protein FOC93_27030 ENOG4108IYU L-aspartate oxidase FOC93_27035 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FOC93_27040 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FOC93_27070 ENOG4108HUF Transporter FOC93_27085 ENOG41061AI Protein of unknown function (DUF2905) FOC93_27100 ENOG4105VIE preprotein translocase, subunit YajC FOC93_27110 ENOG4108QG2 Membrane FOC93_27115 ENOG4105CKP Polysaccharide Biosynthesis Protein FOC93_27125 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOC93_27130 ENOG41076HS cation diffusion facilitator family transporter FOC93_27135 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOC93_27145 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOC93_27150 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FOC93_27160 ENOG4105CUT histidyl-tRNA synthetase FOC93_27170 ENOG4105CUZ uba thif-type nad fad binding protein FOC93_27175 ENOG4108VCI transcription factor, rsfa family FOC93_27180 ENOG4105D1H recombination factor protein RarA FOC93_27190 ENOG4105C3J Cysteine desulfurase FOC93_27195 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FOC93_27205 ENOG4105C7H Helicase, RecD TraA family FOC93_27210 ENOG41060CR FOC93_27225 ENOG4105C02 permease FOC93_27235 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOC93_27255 ENOG4105HHA aminodeoxychorismate lyase FOC93_27265 ENOG4105XYU peptidase (U32 family) FOC93_27270 ENOG4105CFP Peptidase U32 FOC93_27280 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FOC93_27290 ENOG4107XRG penicillin-binding protein FOC93_27320 ENOG4105C28 cystathionine FOC93_27325 ENOG4105C0A alcohol dehydrogenase FOC93_27335 ENOG4108V5C ABC transporter FOC93_27340 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOC93_27380 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOC93_27390 ENOG4105MIR Phenylalanine 4-monooxygenase FOC93_27395 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOC93_27425 ENOG4108MUZ hydrolase FOC93_27430 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FOC93_27435 ENOG4105G6Z alkaline phosphatase FOC93_27450 ENOG4108TVJ Nitroreductase FOC93_27470 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC93_27485 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FOC93_27490 ENOG4105CQW ribosome biogenesis GTPase YqeH FOC93_27500 ENOG410812S Rna-binding protein FOC93_27510 ENOG4108WF2 Metal Dependent Phosphohydrolase FOC93_27520 ENOG4105DXX methyltransferase FOC93_27530 ENOG4105KQC Competence protein FOC93_27535 ENOG4108UK2 deaminase FOC93_27540 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOC93_27550 ENOG4105TQK DNA polymerase iii, delta' subunit FOC93_27575 ENOG4105KVH Transcriptional regulator FOC93_27580 ENOG4105CSA Coproporphyrinogen iii oxidase FOC93_27610 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOC93_27615 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOC93_27625 ENOG4105KTH gatB Yqey FOC93_27630 ENOG41068P3 sporulation protein YqfC FOC93_27640 ENOG4105C9A Phoh family FOC93_27645 ENOG4105CTJ Metal Dependent Phosphohydrolase FOC93_27655 ENOG4107YR5 Diacylglycerol kinase FOC93_27660 ENOG4105KG3 cytidine deaminase FOC93_27665 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOC93_27695 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOC93_27700 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC93_27715 ENOG4105EGD dinuclear metal center protein, YbgI family FOC93_27740 ENOG41069ZM Protein of unknown function (DUF2624) FOC93_27745 ENOG4108JYZ YitT family FOC93_27750 ENOG4105FDK ABC transporter FOC93_27760 ENOG4105N80 Ferric uptake regulator, Fur family FOC93_27785 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOC93_27795 ENOG4107RF6 penicillin-binding protein FOC93_27805 ENOG4105C8U phosphate abc transporter FOC93_27810 ENOG4105C8U phosphate abc transporter FOC93_27815 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FOC93_27820 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOC93_27835 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOC93_27845 ENOG4105DKQ ROK family FOC93_27855 ENOG4105C5X domain protein FOC93_27875 ENOG4105C28 cystathionine FOC93_27880 ENOG4105C28 cystathionine FOC93_27890 ENOG4105C3R Methionine synthase FOC93_27895 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC93_28015 ENOG4105C0D helicase FOC93_28045 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC93_28050 ENOG4105CJ1 ABC, transporter FOC93_28080 ENOG41080TC multidrug resistance protein FOC93_28105 ENOG4105WZW rhodanese family FOC93_28110 ENOG41082GG biotin lipoate A B protein ligase FOC93_28140 ENOG4107YBY Hydrolase FOC93_28150 ENOG4105CBJ Metal-dependent enzyme FOC93_28160 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FOC93_28165 ENOG4105DC7 peptidase M24 FOC93_28190 ENOG4105CD2 stage iii sporulation protein aa FOC93_28195 ENOG4105KR5 Stage iii sporulation protein FOC93_28200 ENOG4108CQH stage III sporulation protein AC FOC93_28205 ENOG4105KQ4 Stage iii sporulation protein ad FOC93_28215 ENOG410644B Stage III sporulation protein af FOC93_28240 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOC93_28245 ENOG4108ZSR alkaline shock protein FOC93_28255 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FOC93_28270 ENOG4105CTB Polyprenyl synthetase FOC93_28280 ENOG4105DX0 Hemolysin A FOC93_28285 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FOC93_28290 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOC93_28295 ENOG4105S1Z Stage IV sporulation protein B FOC93_28300 ENOG4107QQR Sporulation FOC93_28315 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FOC93_28325 ENOG4108JUB Transcriptional regulator FOC93_28335 ENOG4107RDP Dehydrogenase FOC93_28355 ENOG4105CPP Dehydrogenase, E1 component FOC93_28360 ENOG4105C7S Dehydrogenase FOC93_28370 ENOG4108QY0 Membrane FOC93_28380 ENOG4105G7B Protein of unknown function (DUF2992) FOC93_28390 ENOG4108HW3 (ABC) transporter FOC93_28395 ENOG4105E5Q amino acid AbC transporter FOC93_28400 ENOG4105CDA abc transporter atp-binding protein FOC93_28405 ENOG4108QEG Membrane FOC93_28410 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FOC93_28425 ENOG4105D9U N-acetyltransferase FOC93_28430 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOC93_28445 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FOC93_28460 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOC93_28475 ENOG4105EJQ L-serine dehydratase FOC93_28480 ENOG4105II7 pyrroline-5-carboxylate reductase FOC93_28485 ENOG41069FQ Metallo-beta-lactamase superfamily FOC93_28490 ENOG4108IXY short-chain dehydrogenase reductase FOC93_28505 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FOC93_28520 ENOG4105DBV ornithine carbamoyltransferase FOC93_28545 ENOG4105CGH 5'-nucleotidase FOC93_28550 ENOG4105DFD Na H antiporter FOC93_28560 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOC93_28575 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC93_28580 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOC93_28605 ENOG4108R6K riboflavin synthase, subunit alpha FOC93_28610 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FOC93_28630 ENOG4108YM7 Gcn5-related n-acetyltransferase FOC93_28635 ENOG4105ETE Transcriptional regulator (LacI family FOC93_28645 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOC93_28665 ENOG4105RHY Pfam:UPF0157 FOC93_28675 ENOG4105CPC Aldo Keto reductase FOC93_28695 ENOG4105MZ9 stage II sporulation protein m FOC93_28700 ENOG4105I3K Ferric uptake regulator, Fur family FOC93_28710 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOC93_28735 ENOG4105D7N magnesium and cobalt transport protein CorA FOC93_28765 ENOG4105DVE abc transporter atp-binding protein FOC93_28770 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOC93_28775 ENOG4105DZ1 carboxypeptidase FOC93_28780 ENOG41082AN stage II sporulation protein FOC93_28790 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC93_28795 ENOG4105C8J )-transporter FOC93_28815 ENOG41090VF Stage v sporulation protein ac FOC93_28820 ENOG4105CZ3 stage V sporulation protein ad FOC93_28830 ENOG4105G6R Stage v sporulation protein ae FOC93_28840 ENOG4105J7I hydrolase FOC93_28845 ENOG4105PTM secreted protein FOC93_28850 ENOG4107ZE5 PPIases accelerate the folding of proteins FOC93_28885 ENOG4105CE4 GlcNAc 6-P deacetylase FOC93_28905 ENOG4105CID antiterminator FOC93_28920 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOC93_28940 ENOG4105BZU Histidine kinase FOC93_28950 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOC93_28965 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FOC93_28990 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FOC93_29010 ENOG4105DTD Dehydrogenase FOC93_29015 ENOG4105K7K Transcriptional regulator FOC93_29045 ENOG4105CHU acetyl-coa acetyltransferase FOC93_29090 ENOG4105CG3 alpha amylase, catalytic region FOC93_29100 ENOG4107FKK extracellular solute-binding protein family 1 FOC93_29110 ENOG4105EG2 ABC transporter, permease FOC93_29115 ENOG4105FKQ transcriptional regulator FOC93_29120 ENOG4105CHM Aminotransferase FOC93_29130 ENOG4108HGU Histidine kinase FOC93_29150 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FOC93_29185 ENOG4105UIN FOC93_29195 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FOC93_29210 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FOC93_29215 ENOG4105EPM Diguanylate phosphodiesterase FOC93_29230 ENOG4107IN1 Protein of unknown function (DUF1797) FOC93_29240 ENOG4108XRC Protein of unknown function (DUF458) FOC93_29275 ENOG4107ZYR domain protein FOC93_29280 ENOG4105CN5 Metallo-Beta-Lactamase FOC93_29290 ENOG4108X4Q Hydrolase FOC93_29295 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOC93_29310 ENOG4105CPP Dehydrogenase, E1 component FOC93_29360 ENOG4105CXN decarboxylase FOC93_29380 ENOG4105ECY inositol monophosphatase FOC93_29390 ENOG4105CI3 gtp-binding protein typa FOC93_29395 ENOG4105QA2 FOC93_29415 ENOG4108IAB Phoh family FOC93_29430 ENOG4105CNI cell division protein FtsW FOC93_29435 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FOC93_29485 ENOG4106UY4 Inherit from COG: Scp-like extracellular FOC93_29500 ENOG4107TB6 phosphoglycerate mutase FOC93_29520 ENOG4106H78 methyltransferase FOC93_29530 ENOG4105H20 Sporulation integral membrane protein YlbJ FOC93_29535 ENOG4105D78 K07001 NTE family protein FOC93_29540 ENOG41063PX domain protein FOC93_29550 ENOG4105KNH Nucleic acid-binding protein FOC93_29575 ENOG41074B2 UPF0747 protein FOC93_29590 ENOG4105CJN penicillin-binding protein FOC93_29595 ENOG4105CJN penicillin-binding protein FOC93_29600 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOC93_29615 ENOG4105CNI cell division protein FtsW FOC93_29620 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FOC93_29625 ENOG4105D4A Cell wall formation (By similarity) FOC93_29635 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOC93_29640 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOC93_29650 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOC93_29660 ENOG4105WR5 sporulation protein, YlmC YmxH family FOC93_29665 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOC93_29670 ENOG4105DFA alanine racemase domain protein FOC93_29680 ENOG41067XK integral membrane protein FOC93_29685 ENOG4105DBK s4 domain protein FOC93_29710 ENOG4105C34 Pseudouridine synthase FOC93_29730 ENOG4105CD3 dihydroorotase FOC93_29740 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FOC93_29745 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) FOC93_29780 ENOG4105DC7 peptidase M24 FOC93_29800 ENOG4105DSJ YicC domain protein FOC93_29820 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOC93_29825 ENOG4105C25 Primosomal protein n' FOC93_29840 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOC93_29850 ENOG4108ZF3 Phosphatase FOC93_29855 ENOG4105D9P serine threonine protein kinase FOC93_29860 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FOC93_29865 ENOG4105DJV ribulose-phosphate 3-epimerase FOC93_29870 ENOG4105FJ0 thiamine FOC93_29885 ENOG4108ZAA Alkaline-shock protein FOC93_29890 ENOG4105DP4 dak2 domain fusion protein ylov FOC93_29895 ENOG4105CB5 ATP-dependent DNA helicase recG FOC93_29910 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FOC93_29915 ENOG4105CHR reductase FOC93_29930 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOC93_29935 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOC93_29955 ENOG4105VB6 UPF0109 protein FOC93_29980 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FOC93_29995 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOC93_30000 ENOG4105C79 DNA protecting protein DprA FOC93_30005 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOC93_30015 ENOG4108HE4 integrase family FOC93_30045 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOC93_30055 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FOC93_30060 ENOG4105KNE Phosphatidate cytidylyltransferase FOC93_30065 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FOC93_30070 ENOG4105DZP Membrane-associated zinc metalloprotease FOC93_30080 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOC93_30090 ENOG4105CHV Transcription elongation factor NusA FOC93_30095 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FOC93_30100 ENOG4105VHM ribosomal protein FOC93_30110 ENOG4105W7A Protein of unknown function (DUF503) FOC93_30125 ENOG4105DTN riboflavin biosynthesis protein ribF FOC93_30145 ENOG4105C1V Peptidase, M16 FOC93_30155 ENOG4105E35 Dipicolinate synthase subunit A FOC93_30160 ENOG4108S0H Dipicolinic acid synthetase, b subunit FOC93_30165 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOC93_30175 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOC93_30185 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FOC93_30195 ENOG4105CNU cell division protein FtsK FOC93_30200 ENOG4105FDP GntR family transcriptional regulator FOC93_30205 ENOG4105DIH basic membrane FOC93_30210 ENOG4108JQ9 ABC transporter FOC93_30215 ENOG4105UIB (ABC) transporter FOC93_30235 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FOC93_30240 ENOG4105XZV Protein of unknown function (DUF3243) FOC93_30255 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOC93_30285 ENOG4105D48 metallophosphoesterase FOC93_30290 ENOG4105MCT stage V sporulation protein S FOC93_30295 ENOG4108IGT Dipeptidase FOC93_30300 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FOC93_30305 ENOG4105DQU oxidoreductase, subunit beta FOC93_30340 ENOG410890F Dynamin family FOC93_30345 ENOG4105E0M Sulfatase FOC93_30355 ENOG4105F0V Cell wall hydrolase FOC93_30365 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C FOC93_30370 ENOG4105CS2 ec 3.2.1.21 FOC93_30375 ENOG4108S3Y transcriptional regulator FOC93_30395 ENOG41067MG lrgb family FOC93_30415 ENOG4105C5E polysaccharide biosynthesis protein FOC93_30435 ENOG4105BZU Histidine kinase FOC93_30460 ENOG4105D03 DNA-3-methyladenine glycosylase II FOC93_30465 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOC93_30495 ENOG4105E0A ABC, transporter FOC93_30500 ENOG4105NIV Esterase FOC93_30510 ENOG4105VPX protein, conserved in bacteria FOC93_30515 ENOG410681U heavy metal transport detoxification protein FOC93_30520 ENOG4105C59 p-type ATPase FOC93_30530 ENOG4105K70 DNA-binding protein FOC93_30535 ENOG4105TMB Formate nitrite transporter FOC93_30550 ENOG4105C85 amino acid FOC93_30560 ENOG4108SJC Membrane FOC93_30565 ENOG4107QW4 alcohol dehydrogenase FOC93_30570 ENOG4105E98 transcriptional regulator DeoR family FOC93_30575 ENOG4105DE4 1-phosphofructokinase FOC93_30580 ENOG4105DM4 PTS System FOC93_30585 ENOG41069ER domain protein FOC93_30615 ENOG4106F1P AAA ATPase, central domain protein FOC93_30625 ENOG4105EN6 Membrane FOC93_30630 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOC93_30635 ENOG4105CXI aluminum resistance protein FOC93_30640 ENOG4105KV4 Transcriptional regulator FOC93_30645 ENOG4105C5F glutamine synthetase FOC93_30650 ENOG4105K7K Transcriptional regulator FOC93_30670 ENOG4108SVB resolvase FOC93_30680 ENOG4105CGH 5'-nucleotidase FOC93_30685 ENOG4108HW3 (ABC) transporter FOC93_30720 ENOG4105BZ1 (ABC) transporter FOC93_30725 ENOG4105BZ1 (ABC) transporter FOC93_30765 ENOG41067MG lrgb family FOC93_30775 ENOG4107RSM transcriptional regulator FOC93_30790 ENOG4105CJ1 ABC, transporter FOC93_30810 ENOG4107QIV Cytochrome c biogenesis protein FOC93_30835 ENOG4108Z0Z intracellular protease Pfpi family FOC93_30840 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) FOC93_30855 ENOG4105CGP Urocanate hydratase