locus-tag class description FORC21_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FORC21_0003 ENOG410848D S4 domain protein YaaA FORC21_0006 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FORC21_0008 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FORC21_0014 ENOG4105ZMH deoxynucleoside kinase FORC21_0016 ENOG4105GTG Isochorismatase FORC21_0017 ENOG4108Z6B deaminase FORC21_0018 ENOG4105C6E dna polymerase iii FORC21_0022 ENOG41067KS pro-sigma K processing FORC21_0024 ENOG4105CXN decarboxylase FORC21_0026 ENOG4105FA2 dna polymerase iii FORC21_0027 ENOG4105MA4 psp1 domain protein FORC21_0029 ENOG41060K3 Methyltransferase FORC21_0031 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FORC21_0032 ENOG4105KRN Transcriptional regulator, abrb family FORC21_0033 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FORC21_0034 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FORC21_0035 ENOG4105F8V Hydrolase, tatD family FORC21_0036 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FORC21_0038 ENOG4105XFA sporulation peptidase YabG FORC21_0039 ENOG4105W42 Veg protein FORC21_0042 ENOG4105DFT pur operon repressor FORC21_0043 ENOG4105KME endoribonuclease L-psp FORC21_0046 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FORC21_0047 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FORC21_0049 ENOG4108JA2 transcriptioN-repair coupling factor FORC21_0050 ENOG4108M14 stage v sporulation protein t FORC21_0052 ENOG4108IY2 MazG family FORC21_0053 ENOG41082I2 s4 domain protein FORC21_0054 ENOG4105VYY sporulation protein yabp FORC21_0057 ENOG41060GV RNA binding s1 domain protein FORC21_0059 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FORC21_0060 ENOG4108UGV hypoxanthine phosphoribosyltransferase FORC21_0061 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FORC21_0064 ENOG4105C6T cysteine synthase FORC21_0065 ENOG4105CRQ synthase (Component I) FORC21_0066 ENOG4105DDQ anthranilate synthase FORC21_0067 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FORC21_0068 ENOG4105EEI dihydropteroate synthase FORC21_0069 ENOG4105KRF dihydroneopterin aldolase FORC21_0070 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FORC21_0072 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FORC21_0075 ENOG4108Z0C Uvrb UvrC protein FORC21_0078 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FORC21_0079 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) FORC21_0080 ENOG4105CTP PilT protein domain protein FORC21_0081 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FORC21_0084 ENOG4105D7W serine acetyltransferase FORC21_0087 ENOG4105C2N RNA methyltransferase TrmH family group 3 FORC21_0088 ENOG4105M0M Tetracycline resistance protein FORC21_0089 ENOG4105QIV RNA polymerase FORC21_0091 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FORC21_0096 ENOG4107Y49 methyltransferase FORC21_0099 ENOG4105XPM ribosomal protein FORC21_0120 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FORC21_0125 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FORC21_0127 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FORC21_0129 ENOG41067V7 50S ribosomal protein L36 FORC21_0134 ENOG4108JJB ABC transporter FORC21_0135 ENOG4108JJB ABC transporter FORC21_0136 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FORC21_0137 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FORC21_0142 ENOG4105D1F ATP-binding protein FORC21_0145 ENOG4108NMV polysaccharide deacetylase FORC21_0149 ENOG4105C8B TIGR00159 family FORC21_0150 ENOG4107U5W ybbr family FORC21_0152 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FORC21_0157 ENOG4108PSK reductase FORC21_0158 ENOG4108UMI ABC transporter, permease FORC21_0159 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FORC21_0160 ENOG4105D01 (LipO)protein FORC21_0161 ENOG4105CB2 alcohol dehydrogenase FORC21_0163 ENOG4105IQ5 FAD linked oxidase domain protein FORC21_0166 ENOG4105C2C drug resistance transporter, Bcr CflA FORC21_0169 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FORC21_0170 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC21_0171 ENOG4105C3U ABC transporter FORC21_0172 ENOG4108JQ7 (ABC) transporter FORC21_0174 ENOG4108J59 Extracellular solute-binding protein, family 5 FORC21_0179 ENOG4108J59 Extracellular solute-binding protein, family 5 FORC21_0180 ENOG4108J59 Extracellular solute-binding protein, family 5 FORC21_0183 ENOG4106Z1T Nicotinamide Mononucleotide Transporter FORC21_0185 ENOG4105E0C molybdate abc transporter FORC21_0186 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FORC21_0187 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FORC21_0190 ENOG4105EGI Transcriptional regulator FORC21_0194 ENOG4105F6E Acyl-transferase FORC21_0198 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FORC21_0202 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FORC21_0206 ENOG4105C5H ABC transporter FORC21_0208 ENOG4105DEF Extracellular solute-binding protein, family 5 FORC21_0210 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC21_0211 ENOG4105C3U ABC transporter FORC21_0212 ENOG4108JQ7 (ABC) transporter FORC21_0213 ENOG410667J hydrolase FORC21_0219 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FORC21_0220 ENOG4105ERH Fumarylacetoacetate hydrolase FORC21_0222 ENOG4105CUB amino acid FORC21_0223 ENOG4108SC4 )-transporter FORC21_0224 ENOG4105CPF Cell wall formation (By similarity) FORC21_0225 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FORC21_0230 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FORC21_0231 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FORC21_0233 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FORC21_0236 ENOG4105K8N protein family UPF0079, ATPase FORC21_0237 ENOG41072GX Peptidase M22 Glycoprotease FORC21_0238 ENOG410801F ribosomal-protein-alanine acetyltransferase FORC21_0239 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FORC21_0240 ENOG4105C5H ABC transporter FORC21_0243 ENOG4108TYN CAAX amino terminal protease family protein FORC21_0246 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FORC21_0247 ENOG4105C7N Xanthine uracil vitamin C permease FORC21_0249 ENOG4105BZU Histidine kinase FORC21_0251 ENOG4107ZXU DSBA oxidoreductase FORC21_0257 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC21_0260 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FORC21_0262 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) FORC21_0264 ENOG4108SHN Glycosyl transferase, family 2 FORC21_0265 ENOG4105SX7 Transporter FORC21_0267 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FORC21_0268 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FORC21_0269 ENOG4105C83 adenylosuccinate lyase FORC21_0271 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FORC21_0276 ENOG4108V3E phosphoribosylglycinamide formyltransferase FORC21_0277 ENOG4105DC1 bifunctional purine biosynthesis protein purh FORC21_0278 ENOG4105C12 Phosphoribosylglycinamide synthetase FORC21_0283 ENOG4105C4R Atp-dependent dna helicase FORC21_0284 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FORC21_0288 ENOG4108W2Y isochorismatase FORC21_0289 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FORC21_0290 ENOG4108UMI ABC transporter, permease FORC21_0291 ENOG4105D01 (LipO)protein FORC21_0295 ENOG410834F Transcriptional regulator FORC21_0296 ENOG4107I77 yiaA/B two helix domain FORC21_0298 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FORC21_0300 ENOG4105CBD Diacylglycerol kinase FORC21_0302 ENOG4108JPW Aminotransferase FORC21_0304 ENOG4105C26 Dehydrogenase FORC21_0305 ENOG4105KPY Small multidrug resistance protein FORC21_0311 ENOG4105D9N nucleoside FORC21_0312 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FORC21_0316 ENOG4108W15 Protein of unknown function (DUF1456) FORC21_0319 ENOG4105DTQ mandelate racemase muconate lactonizing FORC21_0321 ENOG4105DFD Na H antiporter FORC21_0325 ENOG4105D3R alkyl hydroperoxide reductase FORC21_0326 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FORC21_0327 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FORC21_0328 ENOG4107W7X Aldolase FORC21_0329 ENOG4105EHG Permease protein FORC21_0330 ENOG4105DQ5 transport system permease protein FORC21_0331 ENOG4108V5C ABC transporter FORC21_0332 ENOG4105CAY ferredoxin--nadp reductase FORC21_0335 ENOG4106UIA FORC21_0336 ENOG4106UIA FORC21_0339 ENOG4105BZU Histidine kinase FORC21_0343 ENOG410756H nucleotidyltransferase FORC21_0344 ENOG4105D2S major facilitator superfamily FORC21_0345 ENOG4105D2S major facilitator superfamily FORC21_0348 ENOG4105E5Q amino acid AbC transporter FORC21_0349 ENOG4105EAB amino acid AbC transporter FORC21_0350 ENOG4105CDA abc transporter atp-binding protein FORC21_0351 ENOG4105C8Q Methyl-accepting chemotaxis FORC21_0354 ENOG4105DBV ornithine carbamoyltransferase FORC21_0356 ENOG4105C5B carbamate kinase FORC21_0357 ENOG4108W63 CRP FNR family transcriptional regulator FORC21_0359 ENOG4105DNP FAD linked oxidase domain protein FORC21_0361 ENOG4105CI1 PTS System FORC21_0364 ENOG4105C9U ATP-dependent DNA helicase RecQ FORC21_0365 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase FORC21_0366 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FORC21_0367 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FORC21_0371 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FORC21_0372 ENOG4105D2X ABC transporter substrate-binding protein FORC21_0381 ENOG41062JF Transcriptional regulator FORC21_0384 ENOG4105DEU major facilitator superfamily FORC21_0387 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FORC21_0390 ENOG4108N0M stress protein FORC21_0391 ENOG4106FN3 tellurium resistance protein FORC21_0392 ENOG4106FN3 tellurium resistance protein FORC21_0393 ENOG4107TS3 membrane protein, TerC FORC21_0394 ENOG4108TTB tellurium resistance protein FORC21_0397 ENOG41068PA UPF0435 protein FORC21_0398 ENOG4105KJF protein tyrosine phosphatase FORC21_0400 ENOG4107U9T Pfam:Ribonuclease_BN FORC21_0401 ENOG4105C59 p-type ATPase FORC21_0402 ENOG4108IPJ Membrane FORC21_0404 ENOG4105C3F Signal peptidase i FORC21_0406 ENOG4107ZTW SNARE associated Golgi FORC21_0409 ENOG410606W general stress protein FORC21_0410 ENOG4105UPD Calcium Proton FORC21_0417 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FORC21_0418 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FORC21_0420 ENOG4108JUB Transcriptional regulator FORC21_0422 ENOG4108IQI permease FORC21_0430 ENOG4108A04 Beta-lactamase FORC21_0433 ENOG4105CKK Glycosyl transferase, family 2 FORC21_0434 ENOG4107QQG Dehydrogenase FORC21_0435 ENOG4105C3I Nad-dependent epimerase dehydratase FORC21_0439 ENOG4105F1A Pyruvate formate-lyase FORC21_0440 ENOG4108QBV Monogalactosyldiacylglycerol synthase FORC21_0443 ENOG4105CI2 imidazolone-5-propionate hydrolase FORC21_0444 ENOG4105ECP epimerase FORC21_0450 ENOG41067AE Membrane-bound metal-dependent hydrolase FORC21_0451 ENOG4105CEN a g-specific adenine glycosylase FORC21_0452 ENOG4106BXE FORC21_0456 ENOG4105BZ1 (ABC) transporter FORC21_0457 ENOG4107NBY Membrane FORC21_0458 ENOG4105CBC glutamate synthase FORC21_0460 ENOG4108IUW ABC transporter FORC21_0464 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC21_0465 ENOG4105G5W regulator Fur family FORC21_0469 ENOG4105CDY transcriptional regulatory protein FORC21_0471 ENOG4108JQC penicillin-binding protein 1A FORC21_0472 ENOG4108R9S DSBA oxidoreductase FORC21_0473 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FORC21_0475 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FORC21_0476 ENOG4105BZU Histidine kinase FORC21_0478 ENOG4105CYN Serine protein kinase FORC21_0479 ENOG4106AKX UPF0229 protein FORC21_0482 ENOG4105C94 Transporter FORC21_0485 ENOG4105DZ6 Band 7 protein FORC21_0487 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FORC21_0488 ENOG4108V9W transcriptional regulatory protein FORC21_0489 ENOG4105D4T Citrate transporter FORC21_0494 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FORC21_0495 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC21_0496 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FORC21_0497 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FORC21_0498 ENOG4105BZ7 extracellular solute-binding protein family 1 FORC21_0499 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FORC21_0500 ENOG4108STX response regulator FORC21_0501 ENOG4105US7 Histidine kinase FORC21_0506 ENOG4108MRH transcriptional regulatory protein FORC21_0508 ENOG4105C6K Malic enzyme FORC21_0510 ENOG4108UZ3 Transporter FORC21_0511 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC21_0513 ENOG4105BZU Histidine kinase FORC21_0517 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FORC21_0518 ENOG4108JB9 formate dehydrogenase FORC21_0522 ENOG4105CUB amino acid FORC21_0524 ENOG4105C59 p-type ATPase FORC21_0525 ENOG4105DAP Nicotinate phosphoribosyltransferase FORC21_0532 ENOG41073R8 VanW family FORC21_0533 ENOG4108KGH TRANSCRIPTIONal FORC21_0534 ENOG4105D9N nucleoside FORC21_0535 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FORC21_0536 ENOG4105C37 (CBS) domain FORC21_0537 ENOG4108IJ0 Aspartate ammonia-lyase FORC21_0538 ENOG4105DAA L-lactate FORC21_0541 ENOG4105DUX Transporter FORC21_0542 ENOG4108MES Periplasmic binding protein FORC21_0543 ENOG4105DQ5 transport system permease protein FORC21_0544 ENOG4108IHU transport system permease protein FORC21_0545 ENOG4105E0A ABC, transporter FORC21_0547 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FORC21_0548 ENOG4105EXW epimerase dehydratase FORC21_0550 ENOG4107T89 von Willebrand factor, type A FORC21_0551 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FORC21_0552 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FORC21_0554 ENOG4105BZU Histidine kinase FORC21_0555 ENOG4105D5Q Arginine ornithine antiporter FORC21_0556 ENOG4107414 GntR family transcriptional regulator FORC21_0557 ENOG4105C5Y PTS System FORC21_0558 ENOG4105CG3 alpha amylase, catalytic region FORC21_0561 ENOG4105E1K spore germination protein FORC21_0563 ENOG4105CRN Aminoglycoside phosphotransferase FORC21_0564 ENOG4105BZG amino acid carrier protein FORC21_0565 ENOG4105CDA abc transporter atp-binding protein FORC21_0566 ENOG4105CT1 (ABC) transporter FORC21_0567 ENOG4105EAD ABC transporter FORC21_0568 ENOG4105DRP amino acid AbC transporter FORC21_0569 ENOG4108IQI permease FORC21_0574 ENOG4105D29 Helix-turn-helix type 11 domain protein FORC21_0575 ENOG4105NAE bifunctional deaminase-reductase domain protein FORC21_0576 ENOG4105BZU Histidine kinase FORC21_0581 ENOG4105CHH sulfate transporter FORC21_0582 ENOG41068KF Universal stress protein FORC21_0584 ENOG4105CXY transporter FORC21_0585 ENOG41067TZ transcriptional regulator, MarR family FORC21_0586 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC21_0587 ENOG4105ETE Transcriptional regulator (LacI family FORC21_0588 ENOG4108RVA ribokinase FORC21_0589 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) FORC21_0590 ENOG4105C2J ABC transporter FORC21_0591 ENOG4105CNN ABC, transporter FORC21_0592 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FORC21_0593 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FORC21_0599 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) FORC21_0605 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FORC21_0606 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FORC21_0607 ENOG41069ER domain protein FORC21_0608 ENOG4105VZ8 Transcriptional regulator FORC21_0609 ENOG4107D63 FORC21_0612 ENOG4105DUX Transporter FORC21_0617 ENOG4105C85 amino acid FORC21_0618 ENOG4105C7N Xanthine uracil vitamin C permease FORC21_0621 ENOG4105MA6 gCN5-related N-acetyltransferase FORC21_0626 ENOG4105BZ9 Cytochrome C oxidase, subunit I FORC21_0627 ENOG4105E2S oxidase) subunit II FORC21_0631 ENOG4106CAD Protein of unknown function (DUF3311) FORC21_0632 ENOG4105E1V na solute symporter FORC21_0635 ENOG4108NHD germination protein FORC21_0636 ENOG4105CE1 Ferrous iron transport protein b FORC21_0637 ENOG4105CE1 Ferrous iron transport protein b FORC21_0638 ENOG4105CE1 Ferrous iron transport protein b FORC21_0639 ENOG4105CVA phosphate FORC21_0640 ENOG4105C8U phosphate abc transporter FORC21_0641 ENOG4105E2Z phosphate ABC transporter (Permease FORC21_0644 ENOG41080XQ Signal transduction protein with cbs domains FORC21_0648 ENOG4105ETU transcriptional activator (TenA FORC21_0650 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FORC21_0652 ENOG4108VEU Thiamine monophosphate synthase FORC21_0653 ENOG41080HI glycine oxidase FORC21_0656 ENOG4105D06 uba thif-type nad fad binding protein FORC21_0657 ENOG4105DWF phosphomethylpyrimidine kinase FORC21_0663 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) FORC21_0666 ENOG4108INS Transcriptional regulator FORC21_0671 ENOG4105C19 ABC transporter FORC21_0674 ENOG4105CNN ABC, transporter FORC21_0675 ENOG4105C2J ABC transporter FORC21_0677 ENOG4105C7N Xanthine uracil vitamin C permease FORC21_0679 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FORC21_0683 ENOG4105C5Y PTS System FORC21_0686 ENOG4105K63 Thioredoxin FORC21_0690 ENOG4108B31 Spore germination protein FORC21_0694 ENOG4107Y03 Nitroreductase FORC21_0695 ENOG4105ED1 spovr family FORC21_0697 ENOG4105J4Q Transcriptional regulator FORC21_0700 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FORC21_0701 ENOG4105XTG Pfam:DUF156 FORC21_0702 ENOG4105VFE sira family FORC21_0703 ENOG4107TPS domain protein FORC21_0704 ENOG4105VFE sira family FORC21_0705 ENOG4105VFE sira family FORC21_0706 ENOG41085GJ domain protein FORC21_0707 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FORC21_0708 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FORC21_0709 ENOG41087NI Sulfite exporter TauE/SafE FORC21_0711 ENOG4108KGH TRANSCRIPTIONal FORC21_0716 ENOG4105EMD TRANSCRIPTIONal FORC21_0717 ENOG4105VCP PTS System FORC21_0718 ENOG4105VZJ PTS System FORC21_0722 ENOG41069ER domain protein FORC21_0723 ENOG4107RBB ABC transporter, permease FORC21_0724 ENOG4105C19 ABC transporter FORC21_0730 ENOG4105WEF catalase FORC21_0737 ENOG4107T5V SNARE associated Golgi FORC21_0744 ENOG4105CUB amino acid FORC21_0745 ENOG4107RWR Sodium hydrogen exchanger FORC21_0747 ENOG4106KNT transcriptional regulator FORC21_0748 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FORC21_0755 ENOG4108YXU transcriptional regulator AsnC family FORC21_0756 ENOG4105CH7 arginosuccinase FORC21_0757 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FORC21_0759 ENOG4105KPY Small multidrug resistance protein FORC21_0765 ENOG4105NF4 modulator of drug activity FORC21_0766 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FORC21_0767 ENOG4105E5W Transporter FORC21_0769 ENOG4107RKG DJ-1/PfpI family FORC21_0770 ENOG4105CH6 catalase FORC21_0772 ENOG4105D5Q Arginine ornithine antiporter FORC21_0773 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FORC21_0775 ENOG4105C26 Dehydrogenase FORC21_0776 ENOG4105BZ1 (ABC) transporter FORC21_0777 ENOG4105BZ1 (ABC) transporter FORC21_0779 ENOG4105DRP amino acid AbC transporter FORC21_0780 ENOG4105CDA abc transporter atp-binding protein FORC21_0783 ENOG410839P FORC21_0785 ENOG4108UH6 UPF0754 membrane protein FORC21_0787 ENOG4105BZU Histidine kinase FORC21_0788 ENOG4105WH1 Two component transcriptional regulator luxr family FORC21_0790 ENOG4107FQX Alpha-acetolactate decarboxylase FORC21_0791 ENOG4108VX5 3-methyladenine DNA glycosylase FORC21_0794 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FORC21_0795 ENOG4105D4P Coproporphyrinogen iii oxidase FORC21_0796 ENOG4105CEY Amp-dependent synthetase and ligase FORC21_0799 ENOG4105CHH sulfate transporter FORC21_0804 ENOG4105CGU Enoyl-CoA hydratase FORC21_0808 ENOG4105DER m42 family FORC21_0812 ENOG4105CTU Proline racemase FORC21_0813 ENOG4105CIF Ornithine Cyclodeaminase FORC21_0816 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC21_0817 ENOG4105C3U ABC transporter FORC21_0818 ENOG4108JQ7 (ABC) transporter FORC21_0831 ENOG4108IBT Inherit from COG: transposase FORC21_0864 ENOG4105CSH Transporter FORC21_0866 ENOG4108MRH transcriptional regulatory protein FORC21_0868 ENOG4105M6F mutator MutT protein FORC21_0870 ENOG4105DZR Type I site-specific deoxyribonuclease FORC21_0877 ENOG4105CDU Replicative dna helicase FORC21_0882 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC21_0885 ENOG4105D9U N-acetyltransferase FORC21_0886 ENOG4105EKQ RNA-directed DNA polymerase FORC21_0890 ENOG4105F6J Alpha beta hydrolase fold FORC21_0899 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FORC21_0902 ENOG4105CMT Dihydroxyacetone kinase FORC21_0904 ENOG4105CMT Dihydroxyacetone kinase FORC21_0911 ENOG41069ER domain protein FORC21_0914 ENOG4105DQ6 Transposase FORC21_0919 ENOG4108WC5 Alpha Beta Hydrolase Fold protein FORC21_0929 ENOG4105WN5 stage II sporulation protein FORC21_0931 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC21_0933 ENOG4108MJI response regulator FORC21_0934 ENOG4105BZU Histidine kinase FORC21_0935 ENOG4105BZU Histidine kinase FORC21_0940 ENOG4105K8R UPF0145 protein FORC21_0944 ENOG4107QHE Choloylglycine hydrolase FORC21_0948 ENOG4107VRP DNA repair exonuclease FORC21_0949 ENOG4106D4I domain protein FORC21_0955 ENOG4108MUZ hydrolase FORC21_0960 ENOG4105F0F Oxalate decarboxylase FORC21_0961 ENOG41067QW Transcriptional regulator FORC21_0962 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FORC21_0965 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FORC21_0969 ENOG4105DU6 RNA polymerase FORC21_0972 ENOG4105EEM helicase FORC21_0974 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC21_0979 ENOG4105K59 histidine triad (HIT) protein FORC21_0986 ENOG410905X membrane-flanked domain protein FORC21_0987 ENOG4105CKV Membrane FORC21_0994 ENOG410905X membrane-flanked domain protein FORC21_0995 ENOG4105CKV Membrane FORC21_0996 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FORC21_0997 ENOG4105BZ4 penicillin-binding protein FORC21_0999 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FORC21_1000 ENOG4105C1Q protoporphyrinogen oxidase FORC21_1005 ENOG4105NA0 Transcriptional regulator FORC21_1008 ENOG4105ECB domain protein FORC21_1012 ENOG4108MK9 spermidine N(1)-acetyltransferase FORC21_1014 ENOG4106AXD FORC21_1015 ENOG4108RQ5 Beta-lactamase domain-containing protein FORC21_1016 ENOG4105DF9 Lipoate-protein, ligase FORC21_1018 ENOG4105CEY Amp-dependent synthetase and ligase FORC21_1020 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FORC21_1021 ENOG4108I5D sulfate abc transporter FORC21_1022 ENOG4105ECW sulfate abc transporter FORC21_1023 ENOG4108IJ6 ABC transporter FORC21_1054 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) FORC21_1056 ENOG4105ENX hydrolase FORC21_1057 ENOG4107RN3 metallophosphoesterase FORC21_1058 ENOG4107TVP HD domain protein FORC21_1060 ENOG4108AEY RNA polymerase sigma factor FORC21_1061 ENOG41086D8 Transcriptional regulator FORC21_1063 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC21_1067 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FORC21_1068 ENOG4105C8Q Methyl-accepting chemotaxis FORC21_1069 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) FORC21_1072 ENOG4107QP3 malate synthase g FORC21_1077 ENOG4105VEQ Cold shock protein FORC21_1084 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FORC21_1093 ENOG4105ERH Fumarylacetoacetate hydrolase FORC21_1095 ENOG4105C8Y Acetylornithine aminotransferase FORC21_1096 ENOG4106BKT UPF0344 protein FORC21_1098 ENOG4105CAQ asparagine synthetase FORC21_1099 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FORC21_1100 ENOG4105CH6 catalase FORC21_1101 ENOG4105BZU Histidine kinase FORC21_1104 ENOG4108VPT UPF0234 protein FORC21_1105 ENOG4105QNR S1 RNA binding domain protein FORC21_1117 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC21_1119 ENOG4107AYK membrAne FORC21_1120 ENOG41073B9 FORC21_1122 ENOG4108KP7 hydrolase FORC21_1124 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FORC21_1129 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FORC21_1130 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FORC21_1133 ENOG4105C31 Tryptophanyl-tRNA synthetase FORC21_1136 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FORC21_1137 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC21_1139 ENOG4108JQ7 (ABC) transporter FORC21_1140 ENOG4105UQX Mate efflux family protein FORC21_1144 ENOG4108ZCF integral membrane protein FORC21_1146 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FORC21_1148 ENOG4105DPN Oligoendopeptidase f FORC21_1150 ENOG4108Z18 K06886 hemoglobin FORC21_1151 ENOG4105MIX Adenylate cyclase FORC21_1152 ENOG4106EFP UPF0738 protein FORC21_1154 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FORC21_1155 ENOG4105EMS pseudouridine synthase FORC21_1159 ENOG4105K64 Glycosyl transferase, family 2 FORC21_1163 ENOG4107TVC Glycosyl transferase, family 2 FORC21_1167 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FORC21_1168 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FORC21_1170 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FORC21_1179 ENOG4108ZMI UPF0477 protein FORC21_1184 ENOG4105CK7 Sodium proline symporter FORC21_1185 ENOG4105CRQ synthase (Component I) FORC21_1186 ENOG4105DDQ anthranilate synthase FORC21_1187 ENOG4108I0Q anthranilate phosphoribosyltransferase FORC21_1188 ENOG4105DK0 Indole-3-glycerol phosphate synthase FORC21_1189 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase FORC21_1190 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FORC21_1191 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FORC21_1205 ENOG4105C7S Dehydrogenase FORC21_1207 ENOG4105VZ8 Transcriptional regulator FORC21_1229 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FORC21_1232 ENOG4108IUX (ABC) transporter FORC21_1233 ENOG4105RHA ABC transporter, permease FORC21_1238 ENOG4105DZ1 carboxypeptidase FORC21_1239 ENOG4105VFR signal peptidase FORC21_1246 ENOG4105C26 Dehydrogenase FORC21_1247 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC21_1248 ENOG4105F38 ABC transporter, permease FORC21_1249 ENOG4105D38 putrescine abc transporter FORC21_1250 ENOG4107RUE extracellular solute-binding protein family 1 FORC21_1252 ENOG4105EYF MMPL domain protein FORC21_1254 ENOG4108YBP pseudouridine synthase FORC21_1256 ENOG4105K4I Scp-like extracellular FORC21_1257 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FORC21_1258 ENOG4105CQB FAD linked oxidase domain protein FORC21_1261 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC21_1262 ENOG4105BZU Histidine kinase FORC21_1263 ENOG4105JXH GntR family transcriptional regulator FORC21_1267 ENOG4106A3R peptidase FORC21_1269 ENOG4108QTI )-transporter FORC21_1270 ENOG4107TS3 membrane protein, TerC FORC21_1271 ENOG4105CZN Potassium uptake protein FORC21_1272 ENOG410681C small acid-soluble spore protein FORC21_1273 ENOG4108Z7G MaoC domain protein dehydratase FORC21_1277 ENOG4105CHR reductase FORC21_1283 ENOG4105C4Y ABC transporter FORC21_1284 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC21_1285 ENOG4107RCV ABC transporter, permease FORC21_1289 ENOG4105E98 transcriptional regulator DeoR family FORC21_1292 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FORC21_1294 ENOG4105PXI polysaccharide deacetylase FORC21_1296 ENOG4105BZU Histidine kinase FORC21_1297 ENOG41090MY MarR family Transcriptional regulator FORC21_1299 ENOG4106DF1 FORC21_1301 ENOG4105BZU Histidine kinase FORC21_1302 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FORC21_1303 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FORC21_1304 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FORC21_1312 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FORC21_1313 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FORC21_1314 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FORC21_1315 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FORC21_1316 ENOG4105CZV ABC transporter FORC21_1318 ENOG4105CJ1 ABC, transporter FORC21_1326 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FORC21_1327 ENOG4105EA8 2-Nitropropane dioxygenase FORC21_1328 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FORC21_1330 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FORC21_1335 ENOG4105NQC Flavodoxin FORC21_1343 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FORC21_1348 ENOG4105CZN Potassium uptake protein FORC21_1349 ENOG41063Y9 FORC21_1350 ENOG4105KBJ sporulation protein ytfj FORC21_1354 ENOG4105CM2 brancheD-chain amino acid aminotransferase FORC21_1355 ENOG4105C7K acetolactate synthase FORC21_1356 ENOG4108ZP8 Acetolactate synthase small subunit FORC21_1357 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FORC21_1360 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FORC21_1363 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FORC21_1364 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FORC21_1365 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FORC21_1366 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FORC21_1367 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FORC21_1368 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FORC21_1370 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase FORC21_1371 ENOG4107RVV histidinol phosphate phosphatase, hisj family FORC21_1374 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FORC21_1375 ENOG4105E0M Sulfatase FORC21_1376 ENOG4105E0M Sulfatase FORC21_1378 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FORC21_1381 ENOG4107S4M Sulfate adenylate transferase FORC21_1382 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FORC21_1383 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FORC21_1385 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FORC21_1386 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FORC21_1387 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FORC21_1388 ENOG4105C8J )-transporter FORC21_1393 ENOG4105DFD Na H antiporter FORC21_1397 ENOG4105ENE Histidine kinase FORC21_1398 ENOG4105WH1 Two component transcriptional regulator luxr family FORC21_1402 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FORC21_1407 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FORC21_1411 ENOG4105CJ3 phosphate transporter FORC21_1412 ENOG4107GRR phosphate transport regulator FORC21_1413 ENOG4105BZ4 penicillin-binding protein FORC21_1416 ENOG4105BZU Histidine kinase FORC21_1417 ENOG4105I3N Conserved Protein FORC21_1420 ENOG4105BZU Histidine kinase FORC21_1421 ENOG4105D3A purine nucleoside phosphorylase DeoD-type FORC21_1427 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FORC21_1428 ENOG4105DZ1 carboxypeptidase FORC21_1429 ENOG4108JIC nucleoside recognition domain protein FORC21_1431 ENOG4105FE9 pseudouridine synthase FORC21_1432 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC21_1433 ENOG4107TWT Cytochrome c biogenesis protein FORC21_1434 ENOG4105CRE cytochrome C FORC21_1435 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC21_1436 ENOG4105BZU Histidine kinase FORC21_1437 ENOG4108WBT adenosyltransferase FORC21_1440 ENOG4108SAX Membrane FORC21_1443 ENOG4105C9U ATP-dependent DNA helicase RecQ FORC21_1444 ENOG4105I7S Abortive infection protein FORC21_1446 ENOG4107RGJ metallophosphoesterase FORC21_1447 ENOG4108XDN Transcriptional regulator FORC21_1448 ENOG4108S6Z Negative regulator of genetic competence FORC21_1453 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FORC21_1454 ENOG4107RB3 L-asparaginase FORC21_1458 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FORC21_1461 ENOG4105S2F FORC21_1462 ENOG41065D1 FORC21_1468 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FORC21_1471 ENOG4105XXQ heptaprenyl diphosphate synthase component I FORC21_1473 ENOG4105EAH synthase FORC21_1474 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FORC21_1475 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FORC21_1476 ENOG4105D49 3-dehydroquinate synthase FORC21_1478 ENOG41068YB TPR repeat-containing protein FORC21_1481 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FORC21_1482 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FORC21_1489 ENOG4108JYZ YitT family FORC21_1490 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FORC21_1491 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FORC21_1493 ENOG4105FJR Lmbe family FORC21_1494 ENOG4105CPK Glycosyl transferase (Group 1 FORC21_1499 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FORC21_1502 ENOG4105DVT helicase FORC21_1503 ENOG4105YAC FORC21_1507 ENOG4105CSM endonuclease III FORC21_1509 ENOG4105BZ4 penicillin-binding protein FORC21_1518 ENOG4106F55 Protein of unknown function (DUF1273) FORC21_1520 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FORC21_1522 ENOG4105DVT helicase FORC21_1523 ENOG4105CTD carboxy-peptidase FORC21_1525 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FORC21_1526 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) FORC21_1527 ENOG4105C2W permease FORC21_1528 ENOG4105DHF Membrane FORC21_1529 ENOG410890F Dynamin family FORC21_1531 ENOG4108W0I acetyltransferase FORC21_1533 ENOG4105KHC sulfurtransferase FORC21_1542 ENOG4105HTX biosynthesis protein FORC21_1548 ENOG4105CPK Glycosyl transferase (Group 1 FORC21_1551 ENOG4108SZE gCN5-related N-acetyltransferase FORC21_1555 ENOG41081VK Ribonuclease FORC21_1568 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FORC21_1570 ENOG4107RWR Sodium hydrogen exchanger FORC21_1571 ENOG4105CN5 Metallo-Beta-Lactamase FORC21_1572 ENOG4108Z5V transcriptional regulator, merr family FORC21_1574 ENOG4105H67 Protein of unknown function (DUF421) FORC21_1575 ENOG41080C8 DUF218 domain FORC21_1583 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FORC21_1585 ENOG4107R0U MotA TolQ exbB proton channel FORC21_1586 ENOG4105ER2 Ompa motb domain protein FORC21_1587 ENOG4107YTP response regulator receiver protein FORC21_1588 ENOG4105CBS Chea signal transduction histidine kinase FORC21_1589 ENOG4105DD5 Flagellar motor switch protein FORC21_1592 ENOG4105BZU Histidine kinase FORC21_1596 ENOG4105E1Q flagellar hook-associated protein FORC21_1597 ENOG4105DTJ flagellar hook-associated protein FORC21_1601 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FORC21_1602 ENOG4108ZC9 flagellar basal-body rod protein flgc FORC21_1603 ENOG41075Z6 flagellar hook-basal body complex protein fliE FORC21_1604 ENOG4107U2N Flagellar M-ring protein FORC21_1605 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FORC21_1611 ENOG4105BZE flagellar hook protein, FlgE FORC21_1614 ENOG4107R88 Chemotaxis protein (CheV) FORC21_1616 ENOG4105I03 Flagellin FORC21_1617 ENOG4105I03 Flagellin FORC21_1618 ENOG4105E4C Lytic transglycosylase catalytic FORC21_1620 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FORC21_1621 ENOG4105DD5 Flagellar motor switch protein FORC21_1623 ENOG4105CN7 Flagellar biosynthetic protein FliP FORC21_1624 ENOG4105VS8 Flagellar biosynthetic protein fliq FORC21_1626 ENOG4105D00 flagellar biosynthetic protein flhB FORC21_1627 ENOG4105D7B Flagellar biosynthesis protein flha FORC21_1628 ENOG4105FZW flagellar biosynthesis regulator FlhF FORC21_1629 ENOG4105KTQ flagellar basal-body rod protein FORC21_1630 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FORC21_1637 ENOG4105KAC Antibiotic biosynthesis monooxygenase FORC21_1642 ENOG4105DUM transcriptional regulator, lysR family FORC21_1643 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC21_1645 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FORC21_1646 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FORC21_1652 ENOG4105CVJ phosphoglycerate mutase FORC21_1654 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FORC21_1658 ENOG4105CAQ asparagine synthetase FORC21_1662 ENOG4105PGM cation diffusion facilitator family transporter FORC21_1664 ENOG4105DRR Transcriptional regulator, GntR family FORC21_1665 ENOG4108UZ3 Transporter FORC21_1667 ENOG4105CKI cobalamin synthesis protein FORC21_1668 ENOG4108PJD permease FORC21_1671 ENOG4105DFD Na H antiporter FORC21_1672 ENOG4105VUF Transcriptional regulator FORC21_1674 ENOG4105C9Q fumarate hydratase class II FORC21_1677 ENOG4107QJQ Mate efflux family protein FORC21_1678 ENOG4105EC3 peptidase S51, dipeptidase E FORC21_1682 ENOG4107QIV Cytochrome c biogenesis protein FORC21_1683 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC21_1686 ENOG4107JM4 Tetratricopeptide repeat FORC21_1688 ENOG4105BZC d-serine deaminase FORC21_1689 ENOG4106BRA Membrane FORC21_1696 ENOG4105CJ1 ABC, transporter FORC21_1700 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FORC21_1703 ENOG4108IJ0 Aspartate ammonia-lyase FORC21_1704 ENOG4105C6K Malic enzyme FORC21_1714 ENOG4105FVX FORC21_1715 ENOG4105E09 nadh pyrophosphatase FORC21_1718 ENOG4105CSR polyphosphate kinase 2 FORC21_1719 ENOG4105U3E Transcriptional regulator FORC21_1721 ENOG4105DXI Major Facilitator superfamily FORC21_1725 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FORC21_1726 ENOG4105EU0 Major facilitator Superfamily FORC21_1727 ENOG4105C6T cysteine synthase FORC21_1731 ENOG4105C8J )-transporter FORC21_1733 ENOG4105X5K response regulator receiver protein FORC21_1734 ENOG4105H67 Protein of unknown function (DUF421) FORC21_1739 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FORC21_1740 ENOG4105CHR reductase FORC21_1741 ENOG4105CM2 brancheD-chain amino acid aminotransferase FORC21_1742 ENOG4105C7K acetolactate synthase FORC21_1744 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FORC21_1745 ENOG4105C01 Dihydroxy-acid dehydratase FORC21_1746 ENOG4105C7B Threonine dehydratase FORC21_1751 ENOG4105C6X Major Facilitator FORC21_1752 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FORC21_1754 ENOG4105DY9 regulatoR FORC21_1755 ENOG4105CYC Transferase FORC21_1763 ENOG41068WN FORC21_1767 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FORC21_1768 ENOG4105C72 UPF0176 protein FORC21_1770 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FORC21_1772 ENOG4105C0X amino acid FORC21_1781 ENOG410849A acetyltransferase, (GNAT) family FORC21_1782 ENOG4105K8R UPF0145 protein FORC21_1785 ENOG4107RHR regulatoR FORC21_1787 ENOG4105D9N nucleoside FORC21_1788 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FORC21_1792 ENOG4107RAQ aminopeptidase FORC21_1794 ENOG4107R16 Multicopper oxidase FORC21_1802 ENOG4108T5E Copper resistance protein FORC21_1803 ENOG4105KTB nuclear export factor GLE1 FORC21_1804 ENOG4107RT3 EamA-like transporter family FORC21_1805 ENOG4105GZI Transcriptional regulator FORC21_1806 ENOG4108Z40 Transcriptional regulator FORC21_1807 ENOG4107ZXU DSBA oxidoreductase FORC21_1808 ENOG4108TVJ Nitroreductase FORC21_1810 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FORC21_1811 ENOG4106F5Q Membrane FORC21_1812 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FORC21_1814 ENOG4105CKI cobalamin synthesis protein FORC21_1816 ENOG4105C0Z ABC transporter FORC21_1817 ENOG4108IV0 ABC, transporter FORC21_1818 ENOG4105C32 Amino acid ABC transporter (Permease) FORC21_1820 ENOG4105SKE transcriptional Regulator LysR family FORC21_1824 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FORC21_1826 ENOG4105C4M (Ubiquinol oxidase) subunit I FORC21_1827 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FORC21_1828 ENOG4108JJ9 ABC, transporter FORC21_1829 ENOG4108JJ8 (ABC) transporter FORC21_1831 ENOG4105K64 Glycosyl transferase, family 2 FORC21_1833 ENOG4108UT6 Transferase hexapeptide repeat containing protein FORC21_1844 ENOG4105BZ1 (ABC) transporter FORC21_1845 ENOG4105EFI regulatoR FORC21_1846 ENOG4105BZU Histidine kinase FORC21_1849 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FORC21_1850 ENOG4108ZJ4 polysaccharide deacetylase FORC21_1854 ENOG4105D6E homoserine dehydrogenase FORC21_1856 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FORC21_1859 ENOG4108KGH TRANSCRIPTIONal FORC21_1861 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC21_1862 ENOG4105BZU Histidine kinase FORC21_1863 ENOG4107VMI polysaccharide deacetylase FORC21_1865 ENOG4105KT7 mgtC SapB transporter FORC21_1866 ENOG4105VRR gCN5-related N-acetyltransferase FORC21_1868 ENOG4105DUU IucA IucC family protein FORC21_1869 ENOG4105CEY Amp-dependent synthetase and ligase FORC21_1872 ENOG4108WBH protein TIM barrel FORC21_1873 ENOG4105YWU small acid-soluble spore protein FORC21_1875 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FORC21_1876 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC21_1886 ENOG4105KRN Transcriptional regulator, abrb family FORC21_1888 ENOG4105YVS arsR family transcriptional regulator FORC21_1889 ENOG4105CPC Aldo Keto reductase FORC21_1890 ENOG4107XZQ multidrug resistance protein FORC21_1892 ENOG4105KAF membrAne FORC21_1897 ENOG4105C8Q Methyl-accepting chemotaxis FORC21_1900 ENOG4108K88 Membrane FORC21_1901 ENOG4108WPJ Ferritin-like domain FORC21_1904 ENOG4105DEN Luciferase family FORC21_1907 ENOG4105VMI -acetyltransferase FORC21_1908 ENOG4107QM2 Aldo Keto reductase FORC21_1909 ENOG4105CKI cobalamin synthesis protein FORC21_1911 ENOG4105DSE periplasmic solute binding protein FORC21_1913 ENOG4105K4T epimerase FORC21_1915 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FORC21_1924 ENOG4107T5V SNARE associated Golgi FORC21_1927 ENOG4108PJD permease FORC21_1929 ENOG4108S4H thioesterase Superfamily protein FORC21_1930 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FORC21_1934 ENOG4105SXS Protein of unknown function (DUF456) FORC21_1935 ENOG4105C37 (CBS) domain FORC21_1939 ENOG4108Z7R Chaperone CsaA FORC21_1943 ENOG4108ZRV stage ii sporulation protein p FORC21_1945 ENOG4108VXD carboxy-peptidase FORC21_1947 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FORC21_1951 ENOG4108ZRV stage ii sporulation protein p FORC21_1953 ENOG4108X4Q Hydrolase FORC21_1956 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FORC21_1959 ENOG41087PP glycosyltransferase MGT family FORC21_1960 ENOG4108JYZ YitT family FORC21_1961 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC21_1967 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FORC21_1972 ENOG4106PAW secretion accessory protein EsaA YueB FORC21_1974 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) FORC21_1975 ENOG4108MGT Required for secretion of EsxA and EsxB FORC21_2002 ENOG4105KBJ sporulation protein ytfj FORC21_2007 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FORC21_2012 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FORC21_2014 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FORC21_2015 ENOG4105EMN RNA polymerase sigma factor FORC21_2017 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) FORC21_2019 ENOG4105CNW domain protein FORC21_2021 ENOG4108V06 Glutathione peroxidase FORC21_2024 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FORC21_2026 ENOG4108IUE nitrate reductase beta subunit FORC21_2027 ENOG4105R3A Nitrate reductase FORC21_2029 ENOG4107V6Q Cyclic nucleotide-binding domain FORC21_2030 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FORC21_2031 ENOG4105D06 uba thif-type nad fad binding protein FORC21_2032 ENOG4105CVM Molybdenum cofactor synthesis domain protein FORC21_2033 ENOG4108ZAF Molybdopterin FORC21_2038 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FORC21_2039 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FORC21_2040 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FORC21_2041 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FORC21_2042 ENOG4108IFG nitrite reductase, (NAD(P)H) FORC21_2043 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FORC21_2050 ENOG4105MCT stage V sporulation protein S FORC21_2055 ENOG4108FPN Integrase FORC21_2056 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FORC21_2065 ENOG4105C5H ABC transporter FORC21_2068 ENOG4108UUM single-stranded DNA-binding protein FORC21_2072 ENOG4107YX5 Pfam:DUF548 FORC21_2073 ENOG4105C75 arginyL-tRNA synthetase FORC21_2078 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FORC21_2081 ENOG4105C5S asparaginyl-tRNA synthetase FORC21_2082 ENOG4105BZW Glycerate kinase FORC21_2084 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC21_2085 ENOG41062D9 Histidine kinase FORC21_2088 ENOG4105C8J )-transporter FORC21_2094 ENOG4107XGZ Hydrolase FORC21_2095 ENOG4107XGZ Hydrolase FORC21_2096 ENOG4105CY2 Citrate transporter FORC21_2100 ENOG4105KD7 acetyltransferase FORC21_2102 ENOG4105VMP Transcriptional regulator FORC21_2103 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FORC21_2108 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FORC21_2111 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FORC21_2112 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FORC21_2114 ENOG4107RVG penicillin-binding protein FORC21_2115 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FORC21_2116 ENOG4105E9Q Acyl-transferase FORC21_2117 ENOG4108UT2 hemolysin iii FORC21_2119 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FORC21_2121 ENOG4108RCR degv family FORC21_2123 ENOG4108KF3 Electron transport protein SCO1 SenC FORC21_2124 ENOG4107Y70 Heat shock protein FORC21_2125 ENOG4105CAQ asparagine synthetase FORC21_2128 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FORC21_2129 ENOG4108MES Periplasmic binding protein FORC21_2130 ENOG4105F0I Aminotransferase FORC21_2135 ENOG4105D8X mechanosensitive ion channel FORC21_2136 ENOG4105BZU Histidine kinase FORC21_2137 ENOG4105WH1 Two component transcriptional regulator luxr family FORC21_2138 ENOG4106KNT transcriptional regulator FORC21_2139 ENOG4107ZY0 Phenazine biosynthesis-like protein FORC21_2144 ENOG4105CMG Carbohydrate kinase FORC21_2145 ENOG4105C6Z Gluconate FORC21_2147 ENOG4108YV3 Protein of unknown function (DUF2711) FORC21_2153 ENOG4108IJ8 ABC transporter FORC21_2154 ENOG4105E90 ABC transporter FORC21_2161 ENOG4105C37 (CBS) domain FORC21_2166 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FORC21_2169 ENOG4107S4Y M20 DapE family protein YgeY FORC21_2170 ENOG4108TSC N-acetyltransferase FORC21_2171 ENOG4108JUB Transcriptional regulator FORC21_2172 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FORC21_2181 ENOG410841Q phosphoesterase PA-phosphatase related protein FORC21_2183 ENOG4105SZ6 Thioredoxin FORC21_2184 ENOG4105KNA -acetyltransferase FORC21_2193 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC21_2205 ENOG4105BZ4 penicillin-binding protein FORC21_2207 ENOG4105CZM Major Facilitator FORC21_2208 ENOG4105W8X HesB YadR YfhF-family protein FORC21_2210 ENOG4105DXD 2-methylcitrate dehydratase FORC21_2211 ENOG4105CR4 methylisocitrate lyase FORC21_2212 ENOG4105C1G acyl-Coa dehydrogenase FORC21_2213 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FORC21_2215 ENOG4105N14 lysine exporter protein LysE YggA FORC21_2216 ENOG4105E39 Enoyl-CoA hydratase FORC21_2219 ENOG4107RFY SbcCD D subunit FORC21_2220 ENOG4105EYH Exonuclease FORC21_2225 ENOG4105FCD Major Facilitator FORC21_2226 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FORC21_2227 ENOG4105E4F Isochorismate synthase FORC21_2228 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FORC21_2229 ENOG4105WQI isochorismatase FORC21_2230 ENOG4105CEY Amp-dependent synthetase and ligase FORC21_2231 ENOG4105WQT MbtH domain protein FORC21_2232 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC21_2235 ENOG4105K70 DNA-binding protein FORC21_2239 ENOG4105BZG amino acid carrier protein FORC21_2243 ENOG4105FE9 pseudouridine synthase FORC21_2244 ENOG4105C22 threonyL-tRNA synthetase FORC21_2245 ENOG4105C19 ABC transporter FORC21_2248 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FORC21_2251 ENOG41081I9 integral membrane protein FORC21_2253 ENOG4108Y4K DNA-binding transcriptional activator FORC21_2255 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) FORC21_2257 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FORC21_2259 ENOG4105EYF MMPL domain protein FORC21_2262 ENOG4105WCN acetyltransferase FORC21_2267 ENOG4105C1Q protoporphyrinogen oxidase FORC21_2269 ENOG41068WN FORC21_2275 ENOG4107V2S Transcriptional regulator FORC21_2276 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FORC21_2280 ENOG4105DND Transcriptional regulator FORC21_2281 ENOG4108RPX mosc domain containing protein FORC21_2284 ENOG4105BZ1 (ABC) transporter FORC21_2285 ENOG4105BZ1 (ABC) transporter FORC21_2290 ENOG4108JCI Transcriptional regulator FORC21_2296 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) FORC21_2297 ENOG4108KPJ rna polymerase sigma factor FORC21_2303 ENOG4105F32 YngK protein FORC21_2307 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) FORC21_2308 ENOG4105RD7 BadF BadG BcrA BcrD FORC21_2309 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FORC21_2310 ENOG4107STF Involved in phosphonate degradation (By similarity) FORC21_2311 ENOG4105C7B Threonine dehydratase FORC21_2312 ENOG4108INS Transcriptional regulator FORC21_2317 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FORC21_2319 ENOG4105C1J atp-dependent rna helicase FORC21_2321 ENOG4108RZE Tetr family transcriptional regulator FORC21_2325 ENOG41088CC tellurite resistance protein tehB FORC21_2327 ENOG4108I0C methyltransferase FORC21_2328 ENOG4107RA9 decarboxylase FORC21_2329 ENOG41090HR transcriptional regulator FORC21_2330 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FORC21_2335 ENOG4105CIN aminoacyl-histidine dipeptidase FORC21_2340 ENOG4105KRN Transcriptional regulator, abrb family FORC21_2342 ENOG4105EJ9 Membrane FORC21_2343 ENOG4105EQK -acetyltransferase FORC21_2362 ENOG4105FQP Beta-lactamase FORC21_2363 ENOG4107RVG penicillin-binding protein FORC21_2366 ENOG4107RF6 penicillin-binding protein FORC21_2367 ENOG4107RF6 penicillin-binding protein FORC21_2369 ENOG4105DIN metallophosphoesterase FORC21_2371 ENOG4105CJ1 ABC, transporter FORC21_2373 ENOG4107Z3H Transcriptional regulator, TetR family FORC21_2376 ENOG4105C1G acyl-Coa dehydrogenase FORC21_2377 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FORC21_2378 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FORC21_2379 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FORC21_2380 ENOG4105E39 Enoyl-CoA hydratase FORC21_2381 ENOG4107QX3 carboxylase FORC21_2382 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FORC21_2388 ENOG4105DZ1 carboxypeptidase FORC21_2391 ENOG4105T9C HD domain FORC21_2393 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FORC21_2397 ENOG41075H3 AraC family transcriptional regulator FORC21_2403 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FORC21_2405 ENOG4107Y80 Major Facilitator superfamily FORC21_2406 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FORC21_2407 ENOG4105KVH Transcriptional regulator FORC21_2420 ENOG4105CPQ Dehydrogenase FORC21_2422 ENOG410900G Protein of unknown function (DUF421) FORC21_2423 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FORC21_2425 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FORC21_2427 ENOG4105DK7 lysyl-tRNA synthetase FORC21_2440 ENOG4105D6E homoserine dehydrogenase FORC21_2442 ENOG4105CPF Cell wall formation (By similarity) FORC21_2443 ENOG4105ETU transcriptional activator (TenA FORC21_2458 ENOG4106A3M Cytochrome p-450 FORC21_2463 ENOG410667J hydrolase FORC21_2464 ENOG4105BZU Histidine kinase FORC21_2465 ENOG4107RF6 penicillin-binding protein FORC21_2470 ENOG4108JJB ABC transporter FORC21_2472 ENOG4108HGU Histidine kinase FORC21_2485 ENOG4105CB2 alcohol dehydrogenase FORC21_2486 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FORC21_2487 ENOG4105CJN penicillin-binding protein FORC21_2498 ENOG4107Y80 Major Facilitator superfamily FORC21_2502 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FORC21_2507 ENOG4107Y9U Membrane FORC21_2516 ENOG4105FCD Major Facilitator FORC21_2519 ENOG4105E09 nadh pyrophosphatase FORC21_2520 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FORC21_2524 ENOG4105KME endoribonuclease L-psp FORC21_2525 ENOG4108XI2 Domain of unknown function (DUF1963) FORC21_2529 ENOG4108NRW Phospholipase, patatin family FORC21_2530 ENOG4105KWG Pfam:DUF1696 FORC21_2533 ENOG4108YYS metal-dependent hydrolase (By similarity) FORC21_2536 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FORC21_2538 ENOG4105PKS Excinuclease abc c subunit domain protein FORC21_2544 ENOG4105CJ1 ABC, transporter FORC21_2548 ENOG4107VFR oxidoreductase FORC21_2556 ENOG4105U0R haloacid dehalogenase-like hydrolase FORC21_2560 ENOG4108IUM Glycogen debranching enzyme FORC21_2562 ENOG4105CGH 5'-nucleotidase FORC21_2565 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FORC21_2566 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FORC21_2567 ENOG4105FDR Membrane FORC21_2570 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FORC21_2579 ENOG4105MSI germination protein ypeb FORC21_2585 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) FORC21_2586 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FORC21_2587 ENOG4107Z3H Transcriptional regulator, TetR family FORC21_2592 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FORC21_2595 ENOG4105E98 transcriptional regulator DeoR family FORC21_2598 ENOG41062ES Transcriptional regulator FORC21_2602 ENOG4107QKR Dehydrogenase FORC21_2604 ENOG4107RUY (E1 component), alpha subunit FORC21_2607 ENOG4105E1F short-chain dehydrogenase reductase FORC21_2613 ENOG4107SQ8 Glycine betaine FORC21_2614 ENOG4108IJ7 Glycine betaine FORC21_2616 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FORC21_2619 ENOG4105E66 phosphoriboisomerase A FORC21_2620 ENOG41082BV acetyltransferase FORC21_2621 ENOG4108M1A Chitin-binding protein FORC21_2627 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FORC21_2628 ENOG4105MSB protein, conserved in bacteria FORC21_2632 ENOG4108Z7F N-acetyltransferase FORC21_2638 ENOG4105EEM helicase FORC21_2641 ENOG4105C9U ATP-dependent DNA helicase RecQ FORC21_2650 ENOG4108M1A Chitin-binding protein FORC21_2654 ENOG4105BZG amino acid carrier protein FORC21_2655 ENOG4105C26 Dehydrogenase FORC21_2656 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FORC21_2657 ENOG4105CTU Proline racemase FORC21_2658 ENOG4105CTU Proline racemase FORC21_2659 ENOG41080HI glycine oxidase FORC21_2661 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FORC21_2667 ENOG4105DCI Phosphohydrolase FORC21_2668 ENOG4107T5V SNARE associated Golgi FORC21_2670 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FORC21_2674 ENOG4105DTQ mandelate racemase muconate lactonizing FORC21_2677 ENOG4107SET aldo keto reductase FORC21_2684 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FORC21_2685 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC21_2687 ENOG4105BZU Histidine kinase FORC21_2688 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC21_2693 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 FORC21_2696 ENOG4105DPN Oligoendopeptidase f FORC21_2697 ENOG4105EPR degv family FORC21_2709 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FORC21_2710 ENOG4106K7D Major facilitator family transporter FORC21_2714 ENOG4107BMA Transglycosylase associated protein FORC21_2717 ENOG41089UC methyltransferase, type 11 FORC21_2726 ENOG4105CHM Aminotransferase FORC21_2737 ENOG4105C02 permease FORC21_2739 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FORC21_2740 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FORC21_2741 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FORC21_2742 ENOG4105D7T ABC transporter FORC21_2750 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FORC21_2758 ENOG4107VC0 DNA alkylation repair enzyme FORC21_2760 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FORC21_2762 ENOG4107VMI polysaccharide deacetylase FORC21_2764 ENOG4108ZCF integral membrane protein FORC21_2765 ENOG4105E0M Sulfatase FORC21_2766 ENOG4105C5H ABC transporter FORC21_2768 ENOG4105EYF MMPL domain protein FORC21_2769 ENOG41082JN Transcriptional regulator FORC21_2773 ENOG4105CIH Imidazole acetol-phosphate transaminase FORC21_2774 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FORC21_2775 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FORC21_2783 ENOG41069ER domain protein FORC21_2785 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FORC21_2788 ENOG4105MKU Transcriptional regulator FORC21_2791 ENOG4105D4B ABC, transporter FORC21_2792 ENOG4105F5R ABC transporter FORC21_2793 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FORC21_2795 ENOG4105DKT Transcriptional regulator FORC21_2796 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) FORC21_2798 ENOG41061GT Aldolase FORC21_2800 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FORC21_2807 ENOG4105II7 pyrroline-5-carboxylate reductase FORC21_2809 ENOG4107258 Transcriptional regulator FORC21_2812 ENOG4105ECK Fatty Acid Desaturase FORC21_2814 ENOG4107RBI VanW family FORC21_2815 ENOG4105G6Z alkaline phosphatase FORC21_2817 ENOG4105VMP Transcriptional regulator FORC21_2821 ENOG41068WN FORC21_2827 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FORC21_2832 ENOG4105CKK Glycosyl transferase, family 2 FORC21_2839 ENOG4105C8Y Acetylornithine aminotransferase FORC21_2849 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FORC21_2868 ENOG4108IBT Inherit from COG: transposase FORC21_2872 ENOG4108TVJ Nitroreductase FORC21_2873 ENOG4105FS7 Transcriptional regulator FORC21_2876 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FORC21_2877 ENOG4105WEC Molybdate metabolism regulator FORC21_2879 ENOG4105CMR udp-glucose 4-epimerase FORC21_2880 ENOG4105C19 ABC transporter FORC21_2884 ENOG4108DMH HTH_ARAC FORC21_2885 ENOG4108XET gCN5-related N-acetyltransferase FORC21_2888 ENOG4108PCN EamA-like transporter family FORC21_2890 ENOG4107XJU UPF0178 protein FORC21_2898 ENOG410635A Membrane FORC21_2900 ENOG4108IQI permease FORC21_2902 ENOG4105F1N DNA alkylation repair FORC21_2909 ENOG4107RF6 penicillin-binding protein FORC21_2910 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FORC21_2911 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) FORC21_2914 ENOG4105E7W lamb ycsf family protein FORC21_2916 ENOG4105P4J Allophanate hydrolase, subunit 1 FORC21_2917 ENOG4107258 Transcriptional regulator FORC21_2919 ENOG4106N3A copper homeostasis protein cutc FORC21_2920 ENOG4108ZHR arsR family transcriptional regulator FORC21_2922 ENOG4105FDT acyl-CoA dehydrogenase FORC21_2926 ENOG4105DWD nucleoside recognition domain protein FORC21_2936 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FORC21_2941 ENOG4105E2A Dehydrogenase FORC21_2943 ENOG4108IJ0 Aspartate ammonia-lyase FORC21_2944 ENOG4105HDK L-asparaginase FORC21_2945 ENOG4108IMY Transcriptional regulator FORC21_2947 ENOG4108B31 Spore germination protein FORC21_2949 ENOG4105BZU Histidine kinase FORC21_2954 ENOG41075H3 AraC family transcriptional regulator FORC21_2955 ENOG4105YWU small acid-soluble spore protein FORC21_2956 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FORC21_2957 ENOG4105CUB amino acid FORC21_2958 ENOG4105II7 pyrroline-5-carboxylate reductase FORC21_2959 ENOG4108NHD germination protein FORC21_2960 ENOG4108Q8B Spore germination protein FORC21_2964 ENOG4105CSV Glutaminase FORC21_2968 ENOG4106A3M Cytochrome p-450 FORC21_2971 ENOG4105CGH 5'-nucleotidase FORC21_2973 ENOG4105CHJ isochorismatase hydrolase FORC21_2978 ENOG41090MY MarR family Transcriptional regulator FORC21_2983 ENOG4105F6J Alpha beta hydrolase fold FORC21_2986 ENOG4108606 TspO/MBR family FORC21_2987 ENOG4105CVP deoxyribo-dipyrimidine photolyase FORC21_2992 ENOG4108TWJ NADH dehydrogenase subunit 5 FORC21_2993 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FORC21_2996 ENOG4105E1K spore germination protein FORC21_2997 ENOG4107VMI polysaccharide deacetylase FORC21_2998 ENOG4105KY5 gCN5-related N-acetyltransferase FORC21_2999 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FORC21_3004 ENOG4105Z7P Acetyltransferase (GNAT) family FORC21_3008 ENOG4105DET Rhamnulokinase FORC21_3009 ENOG4107W7X Aldolase FORC21_3011 ENOG4105CNN ABC, transporter FORC21_3013 ENOG4105NWF RbsD or FucU transport FORC21_3014 ENOG4105ETE Transcriptional regulator (LacI family FORC21_3016 ENOG4105D6J arsenicaL-resistance protein FORC21_3017 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FORC21_3018 ENOG41085FC arsR family transcriptional regulator FORC21_3020 ENOG4105NAE bifunctional deaminase-reductase domain protein FORC21_3021 ENOG4107P5I polyketide synthase FORC21_3022 ENOG4108IG5 Transcriptional regulator FORC21_3023 ENOG4105CHR reductase FORC21_3024 ENOG4108YXU transcriptional regulator AsnC family FORC21_3027 ENOG4105D7V transposase FORC21_3049 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC21_3050 ENOG41062D9 Histidine kinase FORC21_3059 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FORC21_3060 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC21_3064 ENOG4105K6H D-cysteine desulfhydrase FORC21_3067 ENOG4105JQZ Methyltransferase FORC21_3071 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FORC21_3075 ENOG4105BZU Histidine kinase FORC21_3077 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FORC21_3082 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FORC21_3086 ENOG4108JQ1 Dehydrogenase FORC21_3087 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FORC21_3090 ENOG41082W1 Cupin 2, conserved barrel domain protein FORC21_3091 ENOG410874W AraC family transcriptional regulator FORC21_3095 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FORC21_3141 ENOG4106YAD MORN repeat variant FORC21_3147 ENOG4108VXD carboxy-peptidase FORC21_3148 ENOG4105PNM synthesis protein FORC21_3150 ENOG4108ISG Major Facilitator FORC21_3153 ENOG4107MII Sugar-specific transcriptional regulator TrmB FORC21_3154 ENOG4105CZM Major Facilitator FORC21_3157 ENOG4105DA5 (ABC) transporter FORC21_3158 ENOG41069JR FORC21_3161 ENOG4105CRW Short chain fatty acid transporter FORC21_3163 ENOG4105DYS nad(p)h dehydrogenase (quinone) FORC21_3175 ENOG4108K8S endonuclease I FORC21_3179 ENOG4108Z66 YbaK ebsC protein FORC21_3180 ENOG4105CUT histidyl-tRNA synthetase FORC21_3183 ENOG4105KVH Transcriptional regulator FORC21_3184 ENOG4108RCM Nitroreductase FORC21_3190 ENOG4108PSK reductase FORC21_3204 ENOG4105C31 Tryptophanyl-tRNA synthetase FORC21_3217 ENOG4105C37 (CBS) domain FORC21_3221 ENOG4105DDN Pentapeptide repeat-containing protein FORC21_3222 ENOG4105XDF Protein of unknown function (DUF1272) FORC21_3223 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FORC21_3224 ENOG4105CMG Carbohydrate kinase FORC21_3225 ENOG4105C6Z Gluconate FORC21_3228 ENOG4105CV1 Transketolase (EC 2.2.1.1) FORC21_3229 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FORC21_3230 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FORC21_3231 ENOG4105CIS alcohol dehydrogenase FORC21_3232 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FORC21_3234 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FORC21_3237 ENOG4105C8Q Methyl-accepting chemotaxis FORC21_3239 ENOG4108UX3 '-nucleotidase FORC21_3240 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FORC21_3241 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FORC21_3242 ENOG4105KVH Transcriptional regulator FORC21_3245 ENOG4105CV8 reductase FORC21_3246 ENOG4105F27 Major Facilitator FORC21_3248 ENOG41090KN UPF0303 protein FORC21_3251 ENOG4105C44 Serine transporter FORC21_3257 ENOG4105KVH Transcriptional regulator FORC21_3258 ENOG4108TZY GntR Family Transcriptional Regulator FORC21_3259 ENOG4105D9R oxidoreductase FORC21_3261 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FORC21_3262 ENOG4105KVH Transcriptional regulator FORC21_3263 ENOG4105KVH Transcriptional regulator FORC21_3271 ENOG4105JAB phenazine biosynthesis protein, phzf family FORC21_3274 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FORC21_3275 ENOG4105KVH Transcriptional regulator FORC21_3278 ENOG4108ZJ4 polysaccharide deacetylase FORC21_3290 ENOG4105DQ6 Transposase FORC21_3295 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FORC21_3301 ENOG4105H3G oxidoreductase FORC21_3315 ENOG4108TN2 lmbE family FORC21_3317 ENOG4107R3E Citrate transporter FORC21_3320 ENOG4108MES Periplasmic binding protein FORC21_3321 ENOG4105EHG Permease protein FORC21_3322 ENOG4105DQ5 transport system permease protein FORC21_3323 ENOG4105NX3 Membrane FORC21_3327 ENOG4107CUJ Protein of unknown function (DUF2690) FORC21_3329 ENOG4107V2S Transcriptional regulator FORC21_3333 ENOG4105C98 muts2 protein FORC21_3335 ENOG4105E5K Alpha-amylase FORC21_3336 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FORC21_3337 ENOG4105DPN Oligoendopeptidase f FORC21_3342 ENOG4105FFC UPF0187 protein FORC21_3345 ENOG4108A04 Beta-lactamase FORC21_3350 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FORC21_3352 ENOG41082BM Transcriptional regulator, arsr family FORC21_3353 ENOG4105CIS alcohol dehydrogenase FORC21_3354 ENOG4105CNG UPF0061 protein FORC21_3360 ENOG4105CQB FAD linked oxidase domain protein FORC21_3368 ENOG4105KT7 mgtC SapB transporter FORC21_3370 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FORC21_3372 ENOG41073R8 VanW family FORC21_3374 ENOG4108R1P FORC21_3378 ENOG4105VEQ Cold shock protein FORC21_3382 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FORC21_3386 ENOG410904N short-chain dehydrogenase reductase FORC21_3388 ENOG4106IQC argininosuccinate lyase FORC21_3391 ENOG4108IA2 Sodium pantothenate symporter FORC21_3393 ENOG4105C26 Dehydrogenase FORC21_3394 ENOG4105CHR reductase FORC21_3396 ENOG4105EWU Squalene--hopene cyclase FORC21_3398 ENOG4105FR1 rard protein FORC21_3399 ENOG410696E Membrane FORC21_3402 ENOG4105D1F ATP-binding protein FORC21_3404 ENOG4108ZAF Molybdopterin FORC21_3405 ENOG4105CVM Molybdenum cofactor synthesis domain protein FORC21_3406 ENOG4105D06 uba thif-type nad fad binding protein FORC21_3407 ENOG4105TMB Formate nitrite transporter FORC21_3409 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FORC21_3410 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FORC21_3412 ENOG4108JB9 formate dehydrogenase FORC21_3413 ENOG4105E1K spore germination protein FORC21_3416 ENOG4105CUB amino acid FORC21_3427 ENOG4107QJT sodium dicarboxylate symporter FORC21_3428 ENOG4108KGH TRANSCRIPTIONal FORC21_3430 ENOG4105EMN RNA polymerase sigma factor FORC21_3432 ENOG4105CIG ABC transporter FORC21_3436 ENOG4105ZX1 Transposase C FORC21_3437 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FORC21_3439 ENOG4108FPN Integrase FORC21_3440 ENOG4105D9R oxidoreductase FORC21_3442 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FORC21_3443 ENOG4105K4P CoA-binding domain protein FORC21_3444 ENOG4105C0H protease FORC21_3445 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC21_3447 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FORC21_3448 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FORC21_3449 ENOG4105W8X HesB YadR YfhF-family protein FORC21_3454 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FORC21_3455 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC21_3458 ENOG4105BZ1 (ABC) transporter FORC21_3459 ENOG4108I0Z Aconitate hydratase FORC21_3465 ENOG4105E5W Transporter FORC21_3467 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FORC21_3471 ENOG4107F3J Amp-dependent synthetase and ligase FORC21_3472 ENOG4107ZYJ bioY protein FORC21_3473 ENOG4105CEY Amp-dependent synthetase and ligase FORC21_3474 ENOG4108IMY Transcriptional regulator FORC21_3481 ENOG4107AYK membrAne FORC21_3483 ENOG4105BZU Histidine kinase FORC21_3484 ENOG4105FBA Phospholipase Carboxylesterase FORC21_3485 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FORC21_3486 ENOG4105CK7 Sodium proline symporter FORC21_3488 ENOG4105CBC glutamate synthase FORC21_3489 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FORC21_3490 ENOG4108VJ1 Transcriptional regulator (CarD family FORC21_3491 ENOG4108903 Formimidoylglutamase FORC21_3502 ENOG4107QIV Cytochrome c biogenesis protein FORC21_3504 ENOG4105CH2 amidohydrolase FORC21_3506 ENOG4105CJ1 ABC, transporter FORC21_3510 ENOG4107RSM transcriptional regulator FORC21_3511 ENOG4105VAW lrga family FORC21_3512 ENOG41067MG lrgb family FORC21_3520 ENOG4105BZ1 (ABC) transporter FORC21_3521 ENOG4105BZ1 (ABC) transporter FORC21_3539 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FORC21_3546 ENOG4108HW3 (ABC) transporter FORC21_3547 ENOG4105CGH 5'-nucleotidase FORC21_3549 ENOG4108SVB resolvase FORC21_3553 ENOG4105K7K Transcriptional regulator FORC21_3555 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FORC21_3556 ENOG4105DR5 peptidase FORC21_3557 ENOG41065S2 pneumococcal vaccine antigen FORC21_3564 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FORC21_3565 ENOG4105C5F glutamine synthetase FORC21_3566 ENOG4105KV4 Transcriptional regulator FORC21_3567 ENOG4105CXI aluminum resistance protein FORC21_3568 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FORC21_3569 ENOG4105EN6 Membrane FORC21_3571 ENOG4106F1P AAA ATPase, central domain protein FORC21_3577 ENOG41069ER domain protein FORC21_3578 ENOG4105DM4 PTS System FORC21_3579 ENOG4105DE4 1-phosphofructokinase FORC21_3580 ENOG4105E98 transcriptional regulator DeoR family FORC21_3581 ENOG4107QW4 alcohol dehydrogenase FORC21_3582 ENOG4108SJC Membrane FORC21_3585 ENOG4105C85 amino acid FORC21_3588 ENOG4105TMB Formate nitrite transporter FORC21_3589 ENOG4105K70 DNA-binding protein FORC21_3591 ENOG4105C59 p-type ATPase FORC21_3592 ENOG410681U heavy metal transport detoxification protein FORC21_3593 ENOG4105VPX protein, conserved in bacteria FORC21_3595 ENOG4105NIV Esterase FORC21_3596 ENOG4105E0A ABC, transporter FORC21_3600 ENOG4105CGK Exodeoxyribonuclease III FORC21_3602 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FORC21_3603 ENOG4105D03 DNA-3-methyladenine glycosylase II FORC21_3604 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FORC21_3608 ENOG4105BZU Histidine kinase FORC21_3615 ENOG41067MG lrgb family FORC21_3619 ENOG4108S3Y transcriptional regulator FORC21_3620 ENOG4105CS2 ec 3.2.1.21 FORC21_3623 ENOG4105F0V Cell wall hydrolase FORC21_3625 ENOG4105E0M Sulfatase FORC21_3626 ENOG410890F Dynamin family FORC21_3632 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FORC21_3633 ENOG4105DQU oxidoreductase, subunit beta FORC21_3634 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FORC21_3635 ENOG4108IGT Dipeptidase FORC21_3636 ENOG4105MCT stage V sporulation protein S FORC21_3637 ENOG4105D48 metallophosphoesterase FORC21_3640 ENOG4105CEV competence damage-inducible protein FORC21_3641 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FORC21_3644 ENOG4105XZV Protein of unknown function (DUF3243) FORC21_3645 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FORC21_3649 ENOG4105UIB (ABC) transporter FORC21_3650 ENOG4108JQ9 ABC transporter FORC21_3651 ENOG4105DIH basic membrane FORC21_3652 ENOG4105FDP GntR family transcriptional regulator FORC21_3653 ENOG4105CNU cell division protein FtsK FORC21_3655 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FORC21_3657 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FORC21_3659 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FORC21_3660 ENOG4108S0H Dipicolinic acid synthetase, b subunit FORC21_3661 ENOG4105E35 Dipicolinate synthase subunit A FORC21_3663 ENOG4105C1V Peptidase, M16 FORC21_3667 ENOG4105DTN riboflavin biosynthesis protein ribF FORC21_3670 ENOG4105W7A Protein of unknown function (DUF503) FORC21_3672 ENOG4105VHM ribosomal protein FORC21_3673 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FORC21_3674 ENOG4105CHV Transcription elongation factor NusA FORC21_3676 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FORC21_3678 ENOG4105DZP Membrane-associated zinc metalloprotease FORC21_3679 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FORC21_3680 ENOG4105KNE Phosphatidate cytidylyltransferase FORC21_3681 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FORC21_3683 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FORC21_3689 ENOG4108HE4 integrase family FORC21_3691 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FORC21_3692 ENOG4105C79 DNA protecting protein DprA FORC21_3693 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FORC21_3696 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FORC21_3702 ENOG4105VB6 UPF0109 protein FORC21_3706 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FORC21_3707 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FORC21_3710 ENOG4105CHR reductase FORC21_3711 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FORC21_3714 ENOG4105CB5 ATP-dependent DNA helicase recG FORC21_3715 ENOG4105DP4 dak2 domain fusion protein ylov FORC21_3716 ENOG4108ZAA Alkaline-shock protein FORC21_3718 ENOG4105FJ0 thiamine FORC21_3719 ENOG4105DJV ribulose-phosphate 3-epimerase FORC21_3720 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FORC21_3721 ENOG4105D9P serine threonine protein kinase FORC21_3722 ENOG4108ZF3 Phosphatase FORC21_3723 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FORC21_3724 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FORC21_3725 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FORC21_3728 ENOG4105C25 Primosomal protein n' FORC21_3729 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FORC21_3733 ENOG4105DSJ YicC domain protein FORC21_3735 ENOG4105F23 Fibronectin-binding protein FORC21_3736 ENOG4105DC7 peptidase M24 FORC21_3741 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FORC21_3744 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) FORC21_3745 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FORC21_3747 ENOG4105CD3 dihydroorotase FORC21_3751 ENOG4105C34 Pseudouridine synthase FORC21_3754 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FORC21_3756 ENOG4105DBK s4 domain protein FORC21_3757 ENOG41067XK integral membrane protein FORC21_3758 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) FORC21_3759 ENOG4105DFA alanine racemase domain protein FORC21_3760 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FORC21_3761 ENOG4105WR5 sporulation protein, YlmC YmxH family FORC21_3763 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC21_3765 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FORC21_3766 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FORC21_3768 ENOG4105D4A Cell wall formation (By similarity) FORC21_3769 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FORC21_3770 ENOG4105CNI cell division protein FtsW FORC21_3771 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FORC21_3773 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FORC21_3774 ENOG4105CJN penicillin-binding protein FORC21_3775 ENOG4105CJN penicillin-binding protein FORC21_3778 ENOG41074B2 UPF0747 protein FORC21_3783 ENOG4105KNH Nucleic acid-binding protein FORC21_3785 ENOG41063PX domain protein FORC21_3786 ENOG4105D78 K07001 NTE family protein FORC21_3787 ENOG4105H20 Sporulation integral membrane protein YlbJ FORC21_3789 ENOG4106H78 methyltransferase FORC21_3793 ENOG4107TB6 phosphoglycerate mutase FORC21_3796 ENOG4106UY4 Inherit from COG: Scp-like extracellular FORC21_3799 ENOG4105EKQ RNA-directed DNA polymerase FORC21_3807 ENOG4107VFP cytochrome oxidase assembly FORC21_3808 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FORC21_3809 ENOG4105CNI cell division protein FtsW FORC21_3812 ENOG4108IAB Phoh family FORC21_3816 ENOG4105QA2 FORC21_3817 ENOG4105CI3 gtp-binding protein typa FORC21_3819 ENOG4105ECY inositol monophosphatase FORC21_3823 ENOG4105CXN decarboxylase FORC21_3833 ENOG4105CPP Dehydrogenase, E1 component FORC21_3836 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FORC21_3837 ENOG4108X4Q Hydrolase FORC21_3839 ENOG4105CN5 Metallo-Beta-Lactamase FORC21_3840 ENOG4107ZYR domain protein FORC21_3847 ENOG4108XRC Protein of unknown function (DUF458) FORC21_3849 ENOG4107IN1 Protein of unknown function (DUF1797) FORC21_3852 ENOG4105EPM Diguanylate phosphodiesterase FORC21_3853 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FORC21_3856 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FORC21_3858 ENOG4105UIN FORC21_3865 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FORC21_3869 ENOG4108HGU Histidine kinase FORC21_3871 ENOG4105CHM Aminotransferase FORC21_3872 ENOG4105FKQ transcriptional regulator FORC21_3873 ENOG4105EG2 ABC transporter, permease FORC21_3875 ENOG4107FKK extracellular solute-binding protein family 1 FORC21_3877 ENOG4105CG3 alpha amylase, catalytic region FORC21_3886 ENOG4105CHU acetyl-coa acetyltransferase FORC21_3892 ENOG4105K7K Transcriptional regulator FORC21_3893 ENOG4105DTD Dehydrogenase FORC21_3896 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FORC21_3897 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FORC21_3899 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate FORC21_3902 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FORC21_3905 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FORC21_3907 ENOG4105BZU Histidine kinase FORC21_3911 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FORC21_3914 ENOG4105CID antiterminator FORC21_3916 ENOG4105FDP GntR family transcriptional regulator FORC21_3918 ENOG4105CE4 GlcNAc 6-P deacetylase FORC21_3925 ENOG4107ZE5 PPIases accelerate the folding of proteins FORC21_3926 ENOG4105PTM secreted protein FORC21_3927 ENOG4105DQF Hydrolase FORC21_3929 ENOG4105G6R Stage v sporulation protein ae FORC21_3931 ENOG4105CZ3 stage V sporulation protein ad FORC21_3932 ENOG41090VF Stage v sporulation protein ac FORC21_3936 ENOG4105C8J )-transporter FORC21_3937 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC21_3939 ENOG41082AN stage II sporulation protein FORC21_3940 ENOG4105DZ1 carboxypeptidase FORC21_3941 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FORC21_3942 ENOG4105DVE abc transporter atp-binding protein FORC21_3949 ENOG4105D7N magnesium and cobalt transport protein CorA FORC21_3954 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FORC21_3956 ENOG4105I3K Ferric uptake regulator, Fur family FORC21_3957 ENOG4105MZ9 stage II sporulation protein m FORC21_3961 ENOG4105CPC Aldo Keto reductase FORC21_3963 ENOG4105RHY Pfam:UPF0157 FORC21_3967 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FORC21_3969 ENOG4105ETE Transcriptional regulator (LacI family FORC21_3970 ENOG4108YM7 Gcn5-related n-acetyltransferase FORC21_3974 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FORC21_3975 ENOG4108R6K riboflavin synthase, subunit alpha FORC21_3980 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FORC21_3981 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FORC21_3983 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FORC21_3984 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FORC21_3986 ENOG4105DFD Na H antiporter FORC21_3987 ENOG4105CGH 5'-nucleotidase FORC21_3992 ENOG4105DBV ornithine carbamoyltransferase FORC21_3995 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FORC21_3998 ENOG4108IXY short-chain dehydrogenase reductase FORC21_3999 ENOG41069FQ Metallo-beta-lactamase superfamily FORC21_4000 ENOG41069FQ Metallo-beta-lactamase superfamily FORC21_4001 ENOG4105II7 pyrroline-5-carboxylate reductase FORC21_4002 ENOG4105EJQ L-serine dehydratase FORC21_4005 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FORC21_4008 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FORC21_4009 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FORC21_4012 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FORC21_4013 ENOG4105D9U N-acetyltransferase FORC21_4015 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FORC21_4016 ENOG4108QEG Membrane FORC21_4017 ENOG4105CDA abc transporter atp-binding protein FORC21_4018 ENOG4105E5Q amino acid AbC transporter FORC21_4019 ENOG4108HW3 (ABC) transporter FORC21_4021 ENOG4105G7B Protein of unknown function (DUF2992) FORC21_4023 ENOG4108QY0 Membrane FORC21_4025 ENOG4105C7S Dehydrogenase FORC21_4026 ENOG4105CPP Dehydrogenase, E1 component FORC21_4029 ENOG4105CKM Branched-chain carboxylic acid kinase FORC21_4030 ENOG4107RDP Dehydrogenase FORC21_4032 ENOG4108JUB Transcriptional regulator FORC21_4034 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FORC21_4037 ENOG4107QQR Sporulation FORC21_4038 ENOG4105S1Z Stage IV sporulation protein B FORC21_4039 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FORC21_4040 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FORC21_4041 ENOG4105DX0 Hemolysin A FORC21_4043 ENOG4105CTB Polyprenyl synthetase FORC21_4046 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FORC21_4048 ENOG4108ZSR alkaline shock protein FORC21_4049 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FORC21_4053 ENOG410644B Stage III sporulation protein af FORC21_4055 ENOG4105KQ4 Stage iii sporulation protein ad FORC21_4056 ENOG4108CQH stage III sporulation protein AC FORC21_4057 ENOG4105KR5 Stage iii sporulation protein FORC21_4058 ENOG4105CD2 stage iii sporulation protein aa FORC21_4063 ENOG4105DC7 peptidase M24 FORC21_4064 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FORC21_4067 ENOG4105CBJ Metal-dependent enzyme FORC21_4069 ENOG4107YBY Hydrolase FORC21_4075 ENOG41082GG biotin lipoate A B protein ligase FORC21_4076 ENOG4105WZW rhodanese family FORC21_4081 ENOG41080TC multidrug resistance protein FORC21_4088 ENOG4105CJ1 ABC, transporter FORC21_4089 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FORC21_4095 ENOG4105C0D helicase FORC21_4103 ENOG4105D03 DNA-3-methyladenine glycosylase II FORC21_4109 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FORC21_4115 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FORC21_4130 ENOG4107R6U sodium dicarboxylate symporter FORC21_4137 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FORC21_4138 ENOG4105C3R Methionine synthase FORC21_4140 ENOG4105C28 cystathionine FORC21_4141 ENOG4105C28 cystathionine FORC21_4145 ENOG4105C5X domain protein FORC21_4147 ENOG4105DKQ ROK family FORC21_4149 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FORC21_4152 ENOG4108UTW Plays a role in the regulation of phosphate uptake FORC21_4153 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FORC21_4154 ENOG4105C8U phosphate abc transporter FORC21_4155 ENOG4105C8U phosphate abc transporter FORC21_4156 ENOG4105EXS phosphate abc transporter FORC21_4157 ENOG4107RF6 penicillin-binding protein FORC21_4159 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FORC21_4163 ENOG4105N80 Ferric uptake regulator, Fur family FORC21_4165 ENOG4105FDK ABC transporter FORC21_4166 ENOG4108JYZ YitT family FORC21_4167 ENOG41069ZM Protein of unknown function (DUF2624) FORC21_4172 ENOG4105EGD dinuclear metal center protein, YbgI family FORC21_4175 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC21_4176 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FORC21_4177 ENOG4107XJU UPF0178 protein FORC21_4182 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FORC21_4183 ENOG4105KG3 cytidine deaminase FORC21_4184 ENOG4107YR5 Diacylglycerol kinase FORC21_4185 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FORC21_4186 ENOG4105CTJ Metal Dependent Phosphohydrolase FORC21_4187 ENOG4105C9A Phoh family FORC21_4189 ENOG41068P3 sporulation protein YqfC FORC21_4190 ENOG4105KTH gatB Yqey FORC21_4192 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FORC21_4193 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FORC21_4199 ENOG4105CSA Coproporphyrinogen iii oxidase FORC21_4200 ENOG4105KVH Transcriptional regulator FORC21_4205 ENOG4105TQK DNA polymerase iii, delta' subunit FORC21_4207 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FORC21_4208 ENOG4108UK2 deaminase FORC21_4209 ENOG4105KQC Competence protein FORC21_4211 ENOG4105DXX methyltransferase FORC21_4213 ENOG4108WF2 Metal Dependent Phosphohydrolase FORC21_4215 ENOG410812S Rna-binding protein FORC21_4217 ENOG4105CQW ribosome biogenesis GTPase YqeH FORC21_4218 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FORC21_4221 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC21_4225 ENOG4108TVJ Nitroreductase FORC21_4228 ENOG4105G6Z alkaline phosphatase FORC21_4229 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FORC21_4230 ENOG4108MUZ hydrolase FORC21_4237 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FORC21_4238 ENOG4105MIR Phenylalanine 4-monooxygenase FORC21_4240 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FORC21_4248 ENOG4105S6R Iron-hydroxamate transporter permease subunit FORC21_4249 ENOG4108V5C ABC transporter FORC21_4251 ENOG4108EKI Dehydrogenase FORC21_4252 ENOG4105C28 cystathionine FORC21_4258 ENOG4107XRG penicillin-binding protein FORC21_4260 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FORC21_4262 ENOG4105CFP Peptidase U32 FORC21_4263 ENOG4105XYU peptidase (U32 family) FORC21_4264 ENOG4108VQJ O-methyltransferase FORC21_4265 ENOG4105HHA aminodeoxychorismate lyase FORC21_4269 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FORC21_4271 ENOG4105C02 permease FORC21_4274 ENOG41060CR FORC21_4275 ENOG4105C7H Helicase, RecD TraA family FORC21_4277 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FORC21_4278 ENOG4105C3J Cysteine desulfurase FORC21_4280 ENOG4105D1H recombination factor protein RarA FORC21_4281 ENOG4108VCI transcription factor, rsfa family FORC21_4282 ENOG4105CUZ uba thif-type nad fad binding protein FORC21_4284 ENOG4105CUT histidyl-tRNA synthetase FORC21_4286 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FORC21_4287 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FORC21_4289 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FORC21_4290 ENOG41076HS cation diffusion facilitator family transporter FORC21_4291 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FORC21_4293 ENOG4105CKP Polysaccharide Biosynthesis Protein FORC21_4294 ENOG4108QG2 Membrane FORC21_4296 ENOG4105VIE preprotein translocase, subunit YajC FORC21_4299 ENOG41061AI Protein of unknown function (DUF2905) FORC21_4302 ENOG4108HUF Transporter FORC21_4307 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FORC21_4308 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FORC21_4309 ENOG4108IYU L-aspartate oxidase FORC21_4312 ENOG4108RPX mosc domain containing protein FORC21_4313 ENOG4105CQC Prephenate dehydratase FORC21_4316 ENOG4105C19 ABC transporter FORC21_4317 ENOG4105EWM Histidine kinase FORC21_4319 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FORC21_4322 ENOG4105X36 (ribosomal) protein FORC21_4324 ENOG4105C03 ribonuclease FORC21_4327 ENOG4107QMS site-determining protein FORC21_4330 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FORC21_4331 ENOG4105DFF Rod shape-determining protein mreb FORC21_4333 ENOG4108Z03 MAF-like protein FORC21_4335 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FORC21_4336 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FORC21_4338 ENOG41068KH stage VI sporulation protein D FORC21_4340 ENOG4105D52 delta-aminolevulinic acid dehydratase FORC21_4345 ENOG4105K56 Transcriptional regulator FORC21_4352 ENOG4108IUQ atp-dependent protease FORC21_4358 ENOG4108QCI YvbH-like oligomerisation region FORC21_4360 ENOG4105M59 Phosphodiesterase, mj0936 family FORC21_4361 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FORC21_4363 ENOG4108XJQ germination protein FORC21_4365 ENOG4108PCX Major Facilitator FORC21_4367 ENOG4105KBX Transcriptional regulator, TetR family FORC21_4397 ENOG4105IRW patatin-like phospholipase family protein FORC21_4401 ENOG4105PFC Transcriptional regulator FORC21_4403 ENOG4105DZC cytosine deaminase FORC21_4404 ENOG41067S9 phage shock protein C, PspC FORC21_4405 ENOG4108JCI Transcriptional regulator FORC21_4407 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FORC21_4408 ENOG4108Z40 Transcriptional regulator FORC21_4409 ENOG4105RHA ABC transporter, permease FORC21_4410 ENOG4108IUX (ABC) transporter FORC21_4411 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FORC21_4412 ENOG4105ER2 Ompa motb domain protein FORC21_4413 ENOG4105E14 MotA TolQ exbB proton channel FORC21_4414 ENOG4108VXD carboxy-peptidase FORC21_4416 ENOG4105E33 succinate dehydrogenase FORC21_4418 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FORC21_4420 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FORC21_4421 ENOG4105K63 Thioredoxin FORC21_4422 ENOG4105C10 Electron transfer flavoprotein FORC21_4423 ENOG4105BZJ Electron transfer flavoprotein FORC21_4424 ENOG41060WC Enoyl-CoA hydratase FORC21_4425 ENOG4107Z3H Transcriptional regulator, TetR family FORC21_4426 ENOG4105CEY Amp-dependent synthetase and ligase FORC21_4428 ENOG4105J76 Periplasmic binding protein FORC21_4429 ENOG4105S6R Iron-hydroxamate transporter permease subunit FORC21_4438 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC21_4441 ENOG4105DR4 Methyltransferase FORC21_4443 ENOG4105KFN sortase, SrtB family FORC21_4444 ENOG4105E0A ABC, transporter FORC21_4447 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FORC21_4449 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FORC21_4451 ENOG4105FE9 pseudouridine synthase FORC21_4454 ENOG4105DCG PHP domain protein FORC21_4457 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FORC21_4460 ENOG4105C5S asparaginyl-tRNA synthetase FORC21_4461 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FORC21_4463 ENOG4108RWN rrna methyltransferase FORC21_4466 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC21_4467 ENOG4105CW7 secretion protein, HlyD family FORC21_4468 ENOG4108JGH Tetr family transcriptional regulator FORC21_4469 ENOG4105CN9 Peptidase m42 family protein FORC21_4473 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FORC21_4474 ENOG4105C22 threonyL-tRNA synthetase FORC21_4475 ENOG4108TDW sporulation protein YtxC FORC21_4480 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FORC21_4481 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FORC21_4482 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FORC21_4484 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FORC21_4485 ENOG4105C2M dna polymerase I FORC21_4486 ENOG4105BZU Histidine kinase FORC21_4487 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC21_4491 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FORC21_4492 ENOG4108HMX isocitrate dehydrogenase (NADP) FORC21_4493 ENOG4105BZN citrate synthase FORC21_4495 ENOG4108REF Sporulation integral membrane protein ytvi FORC21_4496 ENOG4105FS0 cytoplasmic membrane protein FORC21_4501 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FORC21_4502 ENOG4105C6K Malic enzyme FORC21_4503 ENOG4105C0B DNA polymerase III (alpha subunit) FORC21_4504 ENOG4105VV2 FORC21_4506 ENOG4105SFS phosphoesterase RecJ domain protein FORC21_4511 ENOG4105E8R UPF0173 metal-dependent hydrolase FORC21_4512 ENOG4105DC7 peptidase M24 FORC21_4518 ENOG4105Z7P Acetyltransferase (GNAT) family FORC21_4519 ENOG41082W1 Cupin 2, conserved barrel domain protein FORC21_4523 ENOG4107YZX Universal stress protein FORC21_4527 ENOG4105CH7 arginosuccinase FORC21_4532 ENOG4108JYZ YitT family FORC21_4536 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FORC21_4538 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FORC21_4539 ENOG4106F1P AAA ATPase, central domain protein FORC21_4541 ENOG4105KBJ sporulation protein ytfj FORC21_4544 ENOG4105EFZ amidohydrolase FORC21_4546 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FORC21_4551 ENOG4105RQF LysR family Transcriptional regulator FORC21_4553 ENOG4105U5Y Transcriptional regulator FORC21_4555 ENOG4105C28 cystathionine FORC21_4557 ENOG4108IBT Inherit from COG: transposase FORC21_4562 ENOG4108UW5 maltose o-acetyltransferase FORC21_4564 ENOG4105F1V Acetoin utilization protein FORC21_4565 ENOG4105W87 Cbs domain FORC21_4566 ENOG4105DGU Histone deacetylase FORC21_4569 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC21_4571 ENOG4107SNB ankyrin repeat protein YahD FORC21_4572 ENOG4105EP9 oxidoreductase FORC21_4578 ENOG4105ETE Transcriptional regulator (LacI family FORC21_4579 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FORC21_4583 ENOG4105C88 aminopeptidase FORC21_4592 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FORC21_4594 ENOG4108VDD TRNA binding domain protein FORC21_4600 ENOG4105C8F Beta-lactamase domain protein FORC21_4603 ENOG4108V15 phosphotransferase enzyme family FORC21_4604 ENOG4108IUM Glycogen debranching enzyme FORC21_4606 ENOG4107QSE Dipeptidase FORC21_4607 ENOG4105YW5 deoR family transcriptional regulator FORC21_4610 ENOG4105CBX hi0933 family FORC21_4617 ENOG4108VJ1 Transcriptional regulator (CarD family FORC21_4618 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FORC21_4619 ENOG4105CSC Glucose uptake protein FORC21_4622 ENOG4108ZAF Molybdopterin FORC21_4623 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FORC21_4624 ENOG4105CVM Molybdenum cofactor synthesis domain protein FORC21_4626 ENOG4105D06 uba thif-type nad fad binding protein FORC21_4627 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FORC21_4631 ENOG41085GJ domain protein FORC21_4633 ENOG4105DWV Homoserine O-trans-acetylase FORC21_4635 ENOG4108B31 Spore germination protein FORC21_4640 ENOG4105C8T Leucyl-tRNA synthetase FORC21_4641 ENOG410605W Major Facilitator FORC21_4642 ENOG4107S91 Sodium hydrogen exchanger FORC21_4643 ENOG4105NCW Trka-c domain protein FORC21_4646 ENOG4105C19 ABC transporter FORC21_4650 ENOG4105N5T Radical SAM Protein FORC21_4652 ENOG4105CIG ABC transporter FORC21_4657 ENOG4105E8V Alpha Beta Hydrolase Fold protein FORC21_4658 ENOG4108Z0R Transferase FORC21_4659 ENOG4105YVM Phosphoesterase, PA-phosphatase related FORC21_4660 ENOG4105BZF Glycosyl transferase (Group 1 FORC21_4662 ENOG4105EPU Molybdenum cofactor synthesis domain protein FORC21_4664 ENOG4108MK9 spermidine N(1)-acetyltransferase FORC21_4673 ENOG4105BZU Histidine kinase FORC21_4674 ENOG4105BZU Histidine kinase FORC21_4675 ENOG4105CH6 catalase FORC21_4677 ENOG4107S9D Alpha beta hydrolase FORC21_4678 ENOG4107T7U Sulfatase FORC21_4681 ENOG4105D2X ABC transporter substrate-binding protein FORC21_4683 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FORC21_4697 ENOG4108V2W Carbonate dehydratase FORC21_4698 ENOG4105C4M (Ubiquinol oxidase) subunit I FORC21_4699 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FORC21_4706 ENOG41087YS Phage shock protein A FORC21_4712 ENOG4105BZU Histidine kinase FORC21_4713 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC21_4718 ENOG4108UGV hypoxanthine phosphoribosyltransferase FORC21_4719 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FORC21_4728 ENOG4105C19 ABC transporter FORC21_4731 ENOG4107ZTW SNARE associated Golgi FORC21_4734 ENOG4105C19 ABC transporter FORC21_4735 ENOG41086D8 Transcriptional regulator FORC21_4737 ENOG41082BM Transcriptional regulator, arsr family FORC21_4747 ENOG4105C6Z Gluconate FORC21_4748 ENOG4105FDP GntR family transcriptional regulator FORC21_4752 ENOG41069H0 dihydroorotase EC 3.5.2.3 FORC21_4756 ENOG4105DTQ mandelate racemase muconate lactonizing FORC21_4757 ENOG4105CEY Amp-dependent synthetase and ligase FORC21_4758 ENOG4108IPT Naphthoate synthase FORC21_4759 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FORC21_4760 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FORC21_4761 ENOG4105E4F Isochorismate synthase FORC21_4762 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FORC21_4764 ENOG4105VEQ Cold shock protein FORC21_4772 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FORC21_4775 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FORC21_4777 ENOG4105KT7 mgtC SapB transporter FORC21_4778 ENOG4107PBV potassium channel FORC21_4781 ENOG4105WG9 Conserved Protein FORC21_4783 ENOG4105CHM Aminotransferase FORC21_4784 ENOG4108ZB6 transcriptional regulator AsnC family FORC21_4785 ENOG4105C5I Dehydrogenase FORC21_4786 ENOG4108MUZ hydrolase FORC21_4788 ENOG4105C87 Aminotransferase class I and II FORC21_4791 ENOG4105Y38 Kinase-associated protein B FORC21_4793 ENOG4107R3E Citrate transporter FORC21_4796 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FORC21_4797 ENOG4105KA0 thioesterase Superfamily protein FORC21_4800 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FORC21_4805 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) FORC21_4806 ENOG4106YN8 Prenyltransferase FORC21_4807 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FORC21_4808 ENOG41069ER domain protein FORC21_4811 ENOG4105CEP NADH dehydrogenase FORC21_4817 ENOG4105EWC Purine nucleoside phosphorylase FORC21_4822 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FORC21_4826 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FORC21_4827 ENOG4105C4B ABC transporter, permease FORC21_4828 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FORC21_4837 ENOG41083MR nifu domain-containing protein FORC21_4840 ENOG4108W5N phosphatidylglycerophosphatase a FORC21_4842 ENOG4105DYS nad(p)h dehydrogenase (quinone) FORC21_4844 ENOG4105D4U had-superfamily hydrolase, subfamily iia FORC21_4847 ENOG4105CBT Fructose-1,6-bisphosphatase FORC21_4851 ENOG4105MMD transcriptional regulator FORC21_4852 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FORC21_4853 ENOG4107TXC Transcriptional regulator FORC21_4854 ENOG41090T1 Membrane FORC21_4859 ENOG4105FAA peptidase M23 FORC21_4860 ENOG4108YTE sporulation protein YunB FORC21_4861 ENOG4105KZD Domain of unknown function (DUF1805) FORC21_4862 ENOG4107R8B 5'-nucleotidase FORC21_4863 ENOG4105DIW FeS assembly protein SUFB FORC21_4864 ENOG4108UNV SUF system FeS assembly protein, NifU family FORC21_4865 ENOG4105C9B Cysteine desulfurase FORC21_4866 ENOG4105JRK feS assembly protein SufD FORC21_4867 ENOG4105C3K feS assembly ATPase SufC FORC21_4868 ENOG4105D01 (LipO)protein FORC21_4869 ENOG4105D01 (LipO)protein FORC21_4870 ENOG4108UMI ABC transporter, permease FORC21_4876 ENOG41080E8 Transcriptional regulator, Spx MgsR family FORC21_4877 ENOG41080E8 Transcriptional regulator, Spx MgsR family FORC21_4881 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FORC21_4886 ENOG4108W8B Beta-lactamase domain protein FORC21_4887 ENOG4105C1G acyl-Coa dehydrogenase FORC21_4888 ENOG4105CHU acetyl-coa acetyltransferase FORC21_4891 ENOG4105DZ1 carboxypeptidase FORC21_4895 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FORC21_4898 ENOG4108SUT Major Facilitator Superfamily FORC21_4899 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) FORC21_4901 ENOG4107R7I amino acid FORC21_4905 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FORC21_4907 ENOG4107AYK membrAne FORC21_4915 ENOG4107ZTW SNARE associated Golgi FORC21_4917 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FORC21_4918 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC21_4919 ENOG4105BZU Histidine kinase FORC21_4922 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FORC21_4927 ENOG4105C8Q Methyl-accepting chemotaxis FORC21_4928 ENOG4105VG1 fes assembly suf system protein FORC21_4929 ENOG4105D4Y metalloprotease FORC21_4933 ENOG4107T5V SNARE associated Golgi FORC21_4934 ENOG4107S91 Sodium hydrogen exchanger FORC21_4935 ENOG4105NCW Trka-c domain protein FORC21_4937 ENOG4108RMU ferritin dps family protein FORC21_4940 ENOG4108URH decarboxylase FORC21_4942 ENOG41090A1 ferritin FORC21_4944 ENOG4105D9N nucleoside FORC21_4945 ENOG4105D9N nucleoside FORC21_4948 ENOG4108RYK Nad-dependent epimerase dehydratase FORC21_4951 ENOG4105CV8 reductase FORC21_4952 ENOG4105F27 Major Facilitator FORC21_4953 ENOG4105KVH Transcriptional regulator FORC21_4956 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FORC21_4957 ENOG4105D4A Cell wall formation (By similarity) FORC21_4961 ENOG4105WMR Protein CrcB homolog FORC21_4962 ENOG4105WMR Protein CrcB homolog FORC21_4966 ENOG4105C5H ABC transporter FORC21_4967 ENOG4108MK9 spermidine N(1)-acetyltransferase FORC21_4969 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FORC21_4975 ENOG4108IPW abc transporter atp-binding protein FORC21_4976 ENOG4105CM4 permease protein FORC21_4981 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FORC21_4983 ENOG4105XZU Preprotein translocase, subunit SecG FORC21_4984 ENOG41067MG lrgb family FORC21_4988 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FORC21_4994 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC21_4996 ENOG4105RHA ABC transporter, permease FORC21_4997 ENOG4108IUX (ABC) transporter FORC21_4998 ENOG4105BZU Histidine kinase FORC21_4999 ENOG4108W5X Transcriptional Regulator, LuxR family FORC21_5002 ENOG41090VF Stage v sporulation protein ac FORC21_5003 ENOG4105CZ3 stage V sporulation protein ad FORC21_5006 ENOG4108QY0 Membrane FORC21_5007 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FORC21_5008 ENOG4105KRI phosphocarrier protein (HPr FORC21_5010 ENOG4105CHW UPF0052 protein FORC21_5011 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FORC21_5012 ENOG4108Z4K mutator MutT protein FORC21_5014 ENOG4105C3M thioredoxin reductase FORC21_5016 ENOG4108S4C acetyltransferase FORC21_5018 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) FORC21_5020 ENOG41086DT Membrane protein of unknown function FORC21_5021 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FORC21_5022 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FORC21_5025 ENOG4107TXC Transcriptional regulator FORC21_5028 ENOG4105HMI Membrane FORC21_5029 ENOG4105DUM transcriptional regulator, lysR family FORC21_5031 ENOG4108WS4 fmn reductase FORC21_5034 ENOG4105BZ1 (ABC) transporter FORC21_5036 ENOG4105CN1 protease FORC21_5037 ENOG4105CRP Part of the ABC transporter FtsEX involved in FORC21_5038 ENOG4105CAK Cell division ATP-binding protein ftsE FORC21_5040 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) FORC21_5043 ENOG4108RDQ ABC transporter FORC21_5049 ENOG4105MS2 ribosomal subunit Interface protein FORC21_5050 ENOG4105VEQ Cold shock protein FORC21_5051 ENOG41081UC Inherit from COG: Competence protein FORC21_5053 ENOG4105K4H Nlp p60 protein FORC21_5054 ENOG4105KVH Transcriptional regulator FORC21_5056 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FORC21_5057 ENOG4108KGH TRANSCRIPTIONal FORC21_5058 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FORC21_5059 ENOG4105C6Y Udp-glucose 6-dehydrogenase FORC21_5060 ENOG4105ESV Glycosyl transferase, family 4 FORC21_5062 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FORC21_5066 ENOG4105F8D glycoside hydrolase family 4 FORC21_5067 ENOG4105VCP PTS System FORC21_5068 ENOG4105CK1 PTS System FORC21_5070 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FORC21_5071 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FORC21_5072 ENOG4105VCP PTS System FORC21_5074 ENOG4105VZJ PTS System FORC21_5081 ENOG4105ECB domain protein FORC21_5082 ENOG4107RSM transcriptional regulator FORC21_5088 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) FORC21_5089 ENOG4105DAA L-lactate FORC21_5091 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FORC21_5093 ENOG4105E0M Sulfatase FORC21_5095 ENOG4105K4H Nlp p60 protein FORC21_5099 ENOG4107R8N Glycosyl transferase, family 2 FORC21_5101 ENOG4105C94 Transporter FORC21_5102 ENOG41069ER domain protein FORC21_5107 ENOG4105KBK Zinc finger, swim domain protein FORC21_5108 ENOG4105C0D helicase FORC21_5114 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC21_5116 ENOG4107RBB ABC transporter, permease FORC21_5117 ENOG4105C19 ABC transporter FORC21_5119 ENOG4105CXY transporter FORC21_5122 ENOG4105BZU Histidine kinase FORC21_5123 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC21_5124 ENOG4105CMR udp-glucose 4-epimerase FORC21_5126 ENOG4108KGH TRANSCRIPTIONal FORC21_5127 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FORC21_5129 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FORC21_5130 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FORC21_5131 ENOG4105CPK Glycosyl transferase (Group 1 FORC21_5133 ENOG4105H93 Acyltransferase family FORC21_5134 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family FORC21_5137 ENOG4105K64 Glycosyl transferase, family 2 FORC21_5138 ENOG4105D3Q Sugar transferase FORC21_5139 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FORC21_5140 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FORC21_5141 ENOG4107YJ4 chain length determinant protein FORC21_5142 ENOG4105HTX biosynthesis protein FORC21_5143 ENOG4107YJ4 chain length determinant protein FORC21_5146 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FORC21_5148 ENOG4105FRN stage II sporulation protein FORC21_5151 ENOG4108IUW ABC transporter FORC21_5155 ENOG4106778 Protein of unknown function (DUF1146) FORC21_5156 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FORC21_5157 ENOG4105C8S subunit m FORC21_5158 ENOG4105D65 subunit l FORC21_5163 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FORC21_5164 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FORC21_5166 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FORC21_5167 ENOG4105BZU Histidine kinase FORC21_5177 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FORC21_5178 ENOG41062M3 atp synthase FORC21_5181 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FORC21_5183 ENOG4108UIC UPF0340 protein FORC21_5184 ENOG4108YZG isomerase FORC21_5187 ENOG4108VGI doxx family FORC21_5188 ENOG4107XC4 flavin reductase domain protein, FMN-binding FORC21_5192 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FORC21_5194 ENOG4108ZXQ stage ii sporulation protein r FORC21_5195 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FORC21_5196 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FORC21_5197 ENOG4107104 thymidine kinase FORC21_5199 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FORC21_5200 ENOG4105CBT Fructose-1,6-bisphosphatase FORC21_5201 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FORC21_5205 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FORC21_5208 ENOG4105C1G acyl-Coa dehydrogenase FORC21_5209 ENOG4105C1G acyl-Coa dehydrogenase FORC21_5210 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FORC21_5212 ENOG4105DF6 Fe-S oxidoreductase FORC21_5215 ENOG4105BZU Histidine kinase FORC21_5218 ENOG4105D4Y metalloprotease FORC21_5220 ENOG4105BZU Histidine kinase FORC21_5221 ENOG4105KCT ABC transporter FORC21_5222 ENOG4108M15 ABC transporter FORC21_5223 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FORC21_5225 ENOG4105IIU Aminopeptidase FORC21_5229 ENOG4105DU6 RNA polymerase FORC21_5231 ENOG410684U Domain of unknown function (DUF1934) FORC21_5235 ENOG4105CYW agmatinase FORC21_5237 ENOG4105DXB Major Facilitator superfamily FORC21_5238 ENOG4107SWG transcriptional regulator MERR family FORC21_5239 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FORC21_5240 ENOG4105BZ4 penicillin-binding protein FORC21_5241 ENOG4108XFG YwhD family FORC21_5242 ENOG4108Z4T Peptidase M50 FORC21_5243 ENOG41069HH 4-oxalocrotonate tautomerase FORC21_5244 ENOG4105DCI Phosphohydrolase FORC21_5245 ENOG4108MES Periplasmic binding protein FORC21_5246 ENOG4105E0A ABC, transporter FORC21_5247 ENOG4105EHG Permease protein FORC21_5248 ENOG4105DQ5 transport system permease protein FORC21_5250 ENOG4108VCI transcription factor, rsfa family FORC21_5251 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) FORC21_5252 ENOG4108IJ2 phosphate acetyltransferase FORC21_5253 ENOG4107UEZ chlorite dismutase FORC21_5255 ENOG4108VKI Cell wall hydrolase FORC21_5259 ENOG4107SVH Potassium channel protein FORC21_5261 ENOG410667J hydrolase FORC21_5262 ENOG4105VCH membrane FORC21_5264 ENOG4108TU7 Inherit from COG: (ABC) transporter FORC21_5265 ENOG4105CJ1 ABC, transporter FORC21_5266 ENOG41090WU lipolytic protein G-D-S-L family FORC21_5269 ENOG4105D6E homoserine dehydrogenase FORC21_5274 ENOG4108Y4K DNA-binding transcriptional activator FORC21_5276 ENOG4105WH1 Two component transcriptional regulator luxr family FORC21_5277 ENOG4105WH1 Two component transcriptional regulator luxr family FORC21_5278 ENOG4105BZU Histidine kinase FORC21_5279 ENOG4105DWF phosphomethylpyrimidine kinase FORC21_5280 ENOG4105BZU Histidine kinase FORC21_5281 ENOG4105VCD cytoplasmic protein FORC21_5282 ENOG4105D22 carbon starvation protein FORC21_5283 ENOG4105DY9 regulatoR FORC21_5284 ENOG41079KZ Major Facilitator Superfamily FORC21_5286 ENOG4105CG5 Glycosyl transferase (Group 1 FORC21_5288 ENOG4105EN6 Membrane FORC21_5289 ENOG4106YBV Methyl-accepting chemotaxis FORC21_5291 ENOG4108S4H thioesterase Superfamily protein FORC21_5292 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) FORC21_5294 ENOG4105K64 Glycosyl transferase, family 2 FORC21_5296 ENOG4105EJV Membrane FORC21_5297 ENOG4105CKK Glycosyl transferase, family 2 FORC21_5298 ENOG4105C5H ABC transporter FORC21_5299 ENOG41067SE Tetr family transcriptional regulator FORC21_5301 ENOG4105E0X reductase FORC21_5302 ENOG4106F5Q Membrane FORC21_5305 ENOG4108NEV two component transcriptional regulator, LytTR family FORC21_5306 ENOG4108HRK Histidine kinase FORC21_5307 ENOG4107RGD Major Facilitator superfamily FORC21_5310 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FORC21_5312 ENOG4105IW1 AmiS UreI transporter FORC21_5313 ENOG4105CMR udp-glucose 4-epimerase FORC21_5314 ENOG4108UT2 hemolysin iii FORC21_5316 ENOG4105C1J atp-dependent rna helicase FORC21_5317 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) FORC21_5318 ENOG4105DPN Oligoendopeptidase f FORC21_5320 ENOG4105BZU Histidine kinase FORC21_5321 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) FORC21_5323 ENOG4105C0H protease FORC21_5324 ENOG4105Q2H domain protein FORC21_5327 ENOG4105BZU Histidine kinase FORC21_5328 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC21_5329 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FORC21_5330 ENOG4105CDU Replicative dna helicase FORC21_5332 ENOG4105BZR domain protein FORC21_5333 ENOG4108XMW Membrane FORC21_5335 ENOG4108UUM single-stranded DNA-binding protein FORC21_5337 ENOG4105C3G gtp-binding protein FORC21_5338 ENOG4105VDK protein, conserved in bacteria FORC21_5339 ENOG4105D8X mechanosensitive ion channel FORC21_5340 ENOG4108ZDA Sporulation protein YyaC FORC21_5341 ENOG4105FA0 parb-like partition protein FORC21_5342 ENOG4107QJE Chromosome Partitioning Protein FORC21_5345 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FORC21_5346 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FORC21_5348 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FORC21_5352 ENOG4108IMY Transcriptional regulator FORC21_5359 ENOG4107WZZ SMC domain protein FORC21_5363 ENOG4106CVF DNA replication protein FORC21_5380 ENOG4105QBX endodeoxyribonuclease RusA FORC21_t099 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation