locus-tag class description FORC087_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FORC087_0003 ENOG410848D S4 domain protein YaaA FORC087_0006 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FORC087_0008 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FORC087_0014 ENOG4105ZMH deoxynucleoside kinase FORC087_0016 ENOG4105GTG Isochorismatase FORC087_0017 ENOG4108Z6B deaminase FORC087_0018 ENOG4105C6E dna polymerase iii FORC087_0023 ENOG41067KS pro-sigma K processing FORC087_0025 ENOG4105CXN decarboxylase FORC087_0027 ENOG4105FA2 dna polymerase iii FORC087_0028 ENOG4105MA4 psp1 domain protein FORC087_0030 ENOG41060K3 Methyltransferase FORC087_0032 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FORC087_0033 ENOG4105KRN Transcriptional regulator, abrb family FORC087_0034 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FORC087_0035 ENOG4105F8V Hydrolase, tatD family FORC087_0036 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FORC087_0038 ENOG4105XFA sporulation peptidase YabG FORC087_0039 ENOG4105W42 Veg protein FORC087_0042 ENOG4105DFT pur operon repressor FORC087_0043 ENOG4105KME endoribonuclease L-psp FORC087_0046 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FORC087_0047 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FORC087_0049 ENOG4108JA2 transcriptioN-repair coupling factor FORC087_0050 ENOG4108M14 stage v sporulation protein t FORC087_0052 ENOG4108IY2 MazG family FORC087_0053 ENOG41082I2 s4 domain protein FORC087_0054 ENOG4105VYY sporulation protein yabp FORC087_0057 ENOG41060GV RNA binding s1 domain protein FORC087_0059 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FORC087_0060 ENOG4108UGV hypoxanthine phosphoribosyltransferase FORC087_0061 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FORC087_0064 ENOG4105C6T cysteine synthase FORC087_0065 ENOG4105CRQ synthase (Component I) FORC087_0066 ENOG4105DDQ anthranilate synthase FORC087_0067 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FORC087_0068 ENOG4105EEI dihydropteroate synthase FORC087_0069 ENOG4105KRF dihydroneopterin aldolase FORC087_0070 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FORC087_0072 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FORC087_0076 ENOG4108Z0C Uvrb UvrC protein FORC087_0079 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FORC087_0081 ENOG4105CTP PilT protein domain protein FORC087_0082 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FORC087_0085 ENOG4105D7W serine acetyltransferase FORC087_0088 ENOG4105C2N RNA methyltransferase TrmH family group 3 FORC087_0089 ENOG4105M0M Tetracycline resistance protein FORC087_0090 ENOG4105QIV RNA polymerase FORC087_0092 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FORC087_0097 ENOG4107Y49 methyltransferase FORC087_0100 ENOG4105XPM ribosomal protein FORC087_0121 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FORC087_0126 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FORC087_0128 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FORC087_0130 ENOG41067V7 50S ribosomal protein L36 FORC087_0135 ENOG4108JJB ABC transporter FORC087_0136 ENOG4108JJB ABC transporter FORC087_0137 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FORC087_0138 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FORC087_0143 ENOG4105D1F ATP-binding protein FORC087_0146 ENOG4108NMV polysaccharide deacetylase FORC087_015 ENOG41067TZ transcriptional regulator, MarR family FORC087_0150 ENOG4105C8B TIGR00159 family FORC087_0151 ENOG4107U5W ybbr family FORC087_0154 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FORC087_0158 ENOG4108PSK reductase FORC087_0159 ENOG4108UMI ABC transporter, permease FORC087_016 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FORC087_0160 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FORC087_0161 ENOG4105D01 (LipO)protein FORC087_0163 ENOG4105CB2 alcohol dehydrogenase FORC087_0165 ENOG4105IQ5 FAD linked oxidase domain protein FORC087_0168 ENOG4105C2C drug resistance transporter, Bcr CflA FORC087_017 ENOG4105DQ6 Transposase FORC087_0174 ENOG4108J59 Extracellular solute-binding protein, family 5 FORC087_0175 ENOG4108J59 Extracellular solute-binding protein, family 5 FORC087_0179 ENOG4105E0C molybdate abc transporter FORC087_0180 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FORC087_0181 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FORC087_0184 ENOG4105EGI Transcriptional regulator FORC087_0189 ENOG4105F6E Acyl-transferase FORC087_0194 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FORC087_0198 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FORC087_0203 ENOG4105C5H ABC transporter FORC087_0205 ENOG4105BZU Histidine kinase FORC087_0206 ENOG4105WH1 Two component transcriptional regulator luxr family FORC087_0208 ENOG4105CJ1 ABC, transporter FORC087_0209 ENOG41090VJ ABC-2 type transporter FORC087_0210 ENOG4108KYE ABC-2 type transporter FORC087_0212 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FORC087_0214 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC087_0215 ENOG4105C3U ABC transporter FORC087_0216 ENOG4108JQ7 (ABC) transporter FORC087_0217 ENOG410667J hydrolase FORC087_0223 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FORC087_0224 ENOG4105ERH Fumarylacetoacetate hydrolase FORC087_0226 ENOG4105CUB amino acid FORC087_0227 ENOG4108SC4 )-transporter FORC087_0228 ENOG4105CPF Cell wall formation (By similarity) FORC087_0229 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FORC087_0234 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FORC087_0235 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FORC087_0237 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FORC087_0241 ENOG4105K8N protein family UPF0079, ATPase FORC087_0242 ENOG41072GX Peptidase M22 Glycoprotease FORC087_0243 ENOG410801F ribosomal-protein-alanine acetyltransferase FORC087_0244 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FORC087_0245 ENOG4105C5H ABC transporter FORC087_0248 ENOG4108TYN CAAX amino terminal protease family protein FORC087_0252 ENOG4105C7N Xanthine uracil vitamin C permease FORC087_0254 ENOG4105BZU Histidine kinase FORC087_0256 ENOG4107ZXU DSBA oxidoreductase FORC087_0262 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC087_0266 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) FORC087_0269 ENOG4105SX7 Transporter FORC087_0272 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FORC087_0273 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FORC087_0274 ENOG4105C83 adenylosuccinate lyase FORC087_0276 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FORC087_0281 ENOG4108V3E phosphoribosylglycinamide formyltransferase FORC087_0283 ENOG4105C12 Phosphoribosylglycinamide synthetase FORC087_0289 ENOG4105C4R Atp-dependent dna helicase FORC087_0290 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FORC087_0294 ENOG4108W2Y isochorismatase FORC087_0295 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FORC087_0296 ENOG4108UMI ABC transporter, permease FORC087_0297 ENOG4105D01 (LipO)protein FORC087_0301 ENOG410834F Transcriptional regulator FORC087_0302 ENOG4107I77 yiaA/B two helix domain FORC087_0306 ENOG4105CBD Diacylglycerol kinase FORC087_0307 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FORC087_0308 ENOG4108JPW Aminotransferase FORC087_0310 ENOG4105C26 Dehydrogenase FORC087_0311 ENOG4105KPY Small multidrug resistance protein FORC087_0317 ENOG4105D9N nucleoside FORC087_0318 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FORC087_0320 ENOG4108W15 Protein of unknown function (DUF1456) FORC087_0323 ENOG4105DTQ mandelate racemase muconate lactonizing FORC087_0324 ENOG4105DFD Na H antiporter FORC087_0329 ENOG4105D3R alkyl hydroperoxide reductase FORC087_0330 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FORC087_0331 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FORC087_0332 ENOG4107W7X Aldolase FORC087_0333 ENOG4105EHG Permease protein FORC087_0334 ENOG4105DQ5 transport system permease protein FORC087_0335 ENOG4108V5C ABC transporter FORC087_0336 ENOG4105CAY ferredoxin--nadp reductase FORC087_0339 ENOG4106UIA FORC087_034 ENOG4106J6E FORC087_0340 ENOG4106UIA FORC087_0344 ENOG4105BZU Histidine kinase FORC087_0348 ENOG410756H nucleotidyltransferase FORC087_0349 ENOG4105D2S major facilitator superfamily FORC087_0352 ENOG4105E5Q amino acid AbC transporter FORC087_0353 ENOG4105EAB amino acid AbC transporter FORC087_0355 ENOG4105C8Q Methyl-accepting chemotaxis FORC087_0358 ENOG4105DBV ornithine carbamoyltransferase FORC087_0360 ENOG4105C5B carbamate kinase FORC087_0361 ENOG4108W63 CRP FNR family transcriptional regulator FORC087_0363 ENOG4105DNP FAD linked oxidase domain protein FORC087_0365 ENOG4105CI1 PTS System FORC087_0368 ENOG4105C9U ATP-dependent DNA helicase RecQ FORC087_0371 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FORC087_0375 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FORC087_038 ENOG4105D7V transposase FORC087_0383 ENOG41062JF Transcriptional regulator FORC087_0386 ENOG4105DEU major facilitator superfamily FORC087_0389 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FORC087_0392 ENOG4108N0M stress protein FORC087_0393 ENOG4106FN3 tellurium resistance protein FORC087_0394 ENOG4106FN3 tellurium resistance protein FORC087_0395 ENOG4107TS3 membrane protein, TerC FORC087_0396 ENOG4108TTB tellurium resistance protein FORC087_0399 ENOG41068PA UPF0435 protein FORC087_0400 ENOG4105KJF protein tyrosine phosphatase FORC087_0402 ENOG4107U9T Pfam:Ribonuclease_BN FORC087_0404 ENOG4105C59 p-type ATPase FORC087_0405 ENOG4108IPJ Membrane FORC087_0407 ENOG4105C3F Signal peptidase i FORC087_0409 ENOG4107ZTW SNARE associated Golgi FORC087_0412 ENOG410606W general stress protein FORC087_0413 ENOG4105UPD Calcium Proton FORC087_0420 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FORC087_0421 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FORC087_0423 ENOG4108JUB Transcriptional regulator FORC087_0425 ENOG4108IQI permease FORC087_0433 ENOG4108A04 Beta-lactamase FORC087_0436 ENOG4105CKK Glycosyl transferase, family 2 FORC087_0437 ENOG4107QQG Dehydrogenase FORC087_0438 ENOG4105C3I Nad-dependent epimerase dehydratase FORC087_044 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FORC087_0442 ENOG4105F1A Pyruvate formate-lyase FORC087_0443 ENOG4108QBV Monogalactosyldiacylglycerol synthase FORC087_0446 ENOG4105CI2 imidazolone-5-propionate hydrolase FORC087_0447 ENOG4105ECP epimerase FORC087_0453 ENOG41067AE Membrane-bound metal-dependent hydrolase FORC087_0454 ENOG4105CEN a g-specific adenine glycosylase FORC087_0455 ENOG4106BXE FORC087_0460 ENOG4105BZ1 (ABC) transporter FORC087_0461 ENOG4107NBY Membrane FORC087_0463 ENOG4105CBC glutamate synthase FORC087_0465 ENOG4108IUW ABC transporter FORC087_0469 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC087_047 ENOG4105D7V transposase FORC087_0470 ENOG4105G5W regulator Fur family FORC087_0473 ENOG4105CDY transcriptional regulatory protein FORC087_0475 ENOG4108JQC penicillin-binding protein 1A FORC087_0476 ENOG4108R9S DSBA oxidoreductase FORC087_0477 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FORC087_0479 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FORC087_0482 ENOG4105CYN Serine protein kinase FORC087_0486 ENOG4105C94 Transporter FORC087_0489 ENOG4105DZ6 Band 7 protein FORC087_0491 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FORC087_0492 ENOG4108V9W transcriptional regulatory protein FORC087_0493 ENOG4105D4T Citrate transporter FORC087_0498 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FORC087_0499 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC087_0500 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FORC087_0501 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FORC087_0502 ENOG4105BZ7 extracellular solute-binding protein family 1 FORC087_0504 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FORC087_0505 ENOG4108STX response regulator FORC087_0506 ENOG4105US7 Histidine kinase FORC087_0512 ENOG4108MRH transcriptional regulatory protein FORC087_0514 ENOG4105C6K Malic enzyme FORC087_0517 ENOG4108UZ3 Transporter FORC087_0518 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC087_0520 ENOG4105BZU Histidine kinase FORC087_0521 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC087_0525 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FORC087_0526 ENOG4108JB9 formate dehydrogenase FORC087_0530 ENOG4105CUB amino acid FORC087_0533 ENOG4105C59 p-type ATPase FORC087_0534 ENOG4105DAP Nicotinate phosphoribosyltransferase FORC087_0541 ENOG41073R8 VanW family FORC087_0542 ENOG4108KGH TRANSCRIPTIONal FORC087_0543 ENOG4105D9N nucleoside FORC087_0544 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FORC087_0545 ENOG4105C37 (CBS) domain FORC087_0546 ENOG4108IJ0 Aspartate ammonia-lyase FORC087_0547 ENOG4105DAA L-lactate FORC087_0550 ENOG4105DUX Transporter FORC087_0551 ENOG4108MES Periplasmic binding protein FORC087_0552 ENOG4105DQ5 transport system permease protein FORC087_0553 ENOG4108IHU transport system permease protein FORC087_0554 ENOG4105E0A ABC, transporter FORC087_0555 ENOG4105DMQ Methyltransferase FORC087_0556 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FORC087_0557 ENOG4105EXW epimerase dehydratase FORC087_0559 ENOG4107T89 von Willebrand factor, type A FORC087_0560 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FORC087_0561 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FORC087_0563 ENOG4105BZU Histidine kinase FORC087_0564 ENOG4105D5Q Arginine ornithine antiporter FORC087_0565 ENOG4107414 GntR family transcriptional regulator FORC087_0566 ENOG4105C5Y PTS System FORC087_0567 ENOG4105CG3 alpha amylase, catalytic region FORC087_0570 ENOG4105E1K spore germination protein FORC087_0571 ENOG4105CRN Aminoglycoside phosphotransferase FORC087_0572 ENOG4105BZG amino acid carrier protein FORC087_0574 ENOG4105CDA abc transporter atp-binding protein FORC087_0575 ENOG4105CT1 (ABC) transporter FORC087_0576 ENOG4105EAD ABC transporter FORC087_0577 ENOG4105DRP amino acid AbC transporter FORC087_0578 ENOG4108IQI permease FORC087_0581 ENOG4105GFR rna polymerase sigma factor FORC087_0583 ENOG4105D29 Helix-turn-helix type 11 domain protein FORC087_0584 ENOG4105NAE bifunctional deaminase-reductase domain protein FORC087_0585 ENOG4105BZU Histidine kinase FORC087_0588 ENOG4105CHH sulfate transporter FORC087_0590 ENOG41068KF Universal stress protein FORC087_0592 ENOG4105CXY transporter FORC087_0594 ENOG41067TZ transcriptional regulator, MarR family FORC087_0595 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC087_0596 ENOG4105ETE Transcriptional regulator (LacI family FORC087_0597 ENOG4108RVA ribokinase FORC087_0599 ENOG4105C2J ABC transporter FORC087_0600 ENOG4105CNN ABC, transporter FORC087_0601 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FORC087_0602 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FORC087_0610 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) FORC087_0616 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FORC087_0617 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FORC087_0618 ENOG41069ER domain protein FORC087_0619 ENOG4105VZ8 Transcriptional regulator FORC087_0620 ENOG4107D63 FORC087_0623 ENOG4105DUX Transporter FORC087_0628 ENOG4105C85 amino acid FORC087_0629 ENOG4105C7N Xanthine uracil vitamin C permease FORC087_0632 ENOG4105MA6 gCN5-related N-acetyltransferase FORC087_0636 ENOG4105CCU oxidase (Subunit III) FORC087_0637 ENOG4105BZ9 Cytochrome C oxidase, subunit I FORC087_0638 ENOG4105E2S oxidase) subunit II FORC087_0642 ENOG4106CAD Protein of unknown function (DUF3311) FORC087_0643 ENOG4105E1V na solute symporter FORC087_0646 ENOG4108NHD germination protein FORC087_0648 ENOG4105CE1 Ferrous iron transport protein b FORC087_0649 ENOG4105CE1 Ferrous iron transport protein b FORC087_0650 ENOG4105CE1 Ferrous iron transport protein b FORC087_0651 ENOG4105CVA phosphate FORC087_0652 ENOG4105C8U phosphate abc transporter FORC087_0653 ENOG4105E2Z phosphate ABC transporter (Permease FORC087_0656 ENOG41080XQ Signal transduction protein with cbs domains FORC087_0660 ENOG4105ETU transcriptional activator (TenA FORC087_0662 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FORC087_0664 ENOG4108VEU Thiamine monophosphate synthase FORC087_0665 ENOG41080HI glycine oxidase FORC087_0668 ENOG4105D06 uba thif-type nad fad binding protein FORC087_0669 ENOG4105DWF phosphomethylpyrimidine kinase FORC087_0679 ENOG4108INS Transcriptional regulator FORC087_0684 ENOG4105C19 ABC transporter FORC087_0686 ENOG4105C7N Xanthine uracil vitamin C permease FORC087_0688 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FORC087_0691 ENOG4105K63 Thioredoxin FORC087_0695 ENOG4108B31 Spore germination protein FORC087_0699 ENOG4107Y03 Nitroreductase FORC087_0700 ENOG4105ED1 spovr family FORC087_0703 ENOG4108TCS Glutamyl endopeptidase FORC087_0705 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FORC087_0706 ENOG4105XTG Pfam:DUF156 FORC087_0707 ENOG4105VFE sira family FORC087_0708 ENOG4107TPS domain protein FORC087_0709 ENOG4105VFE sira family FORC087_0710 ENOG4105VFE sira family FORC087_0712 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FORC087_0713 ENOG41087NI Sulfite exporter TauE/SafE FORC087_0715 ENOG4108KGH TRANSCRIPTIONal FORC087_0720 ENOG4105EMD TRANSCRIPTIONal FORC087_0721 ENOG4105VCP PTS System FORC087_0722 ENOG4105VZJ PTS System FORC087_0727 ENOG41069ER domain protein FORC087_0728 ENOG4107RBB ABC transporter, permease FORC087_0729 ENOG4105C19 ABC transporter FORC087_0735 ENOG4105WEF catalase FORC087_0742 ENOG4107T5V SNARE associated Golgi FORC087_0749 ENOG4105CUB amino acid FORC087_075 ENOG4105E5W Transporter FORC087_0750 ENOG4107RWR Sodium hydrogen exchanger FORC087_0752 ENOG4106KNT transcriptional regulator FORC087_0760 ENOG4108YXU transcriptional regulator AsnC family FORC087_0761 ENOG4105CH7 arginosuccinase FORC087_0762 ENOG4105UBK short-chain dehydrogenase reductase FORC087_0764 ENOG4105KPY Small multidrug resistance protein FORC087_0772 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FORC087_0773 ENOG4105E5W Transporter FORC087_0776 ENOG4107RKG DJ-1/PfpI family FORC087_0777 ENOG4105CH6 catalase FORC087_0779 ENOG4105D5Q Arginine ornithine antiporter FORC087_0780 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FORC087_0782 ENOG4105C26 Dehydrogenase FORC087_0784 ENOG4105BZ1 (ABC) transporter FORC087_0785 ENOG4105BZ1 (ABC) transporter FORC087_0788 ENOG4105DRP amino acid AbC transporter FORC087_0789 ENOG4105CDA abc transporter atp-binding protein FORC087_0792 ENOG410839P FORC087_0799 ENOG4107FQX Alpha-acetolactate decarboxylase FORC087_0800 ENOG4108VX5 3-methyladenine DNA glycosylase FORC087_0803 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FORC087_0804 ENOG4105D4P Coproporphyrinogen iii oxidase FORC087_0805 ENOG4105CEY Amp-dependent synthetase and ligase FORC087_0808 ENOG4105CHH sulfate transporter FORC087_0813 ENOG4105CGU Enoyl-CoA hydratase FORC087_0817 ENOG4105DER m42 family FORC087_082 ENOG4105EWM Histidine kinase FORC087_0826 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC087_0827 ENOG4105C3U ABC transporter FORC087_0828 ENOG4108JQ7 (ABC) transporter FORC087_0838 ENOG4105DQ6 Transposase FORC087_0844 ENOG4108IBT Inherit from COG: transposase FORC087_0851 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) FORC087_0861 ENOG4105CSH Transporter FORC087_0863 ENOG4108MRH transcriptional regulatory protein FORC087_0876 ENOG4105CDU Replicative dna helicase FORC087_0881 ENOG4108Z86 Glutamine amidotransferase FORC087_0885 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC087_0891 ENOG4105D9U N-acetyltransferase FORC087_0904 ENOG4105F6J Alpha beta hydrolase fold FORC087_0907 ENOG4105VZ8 Transcriptional regulator FORC087_0910 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FORC087_0921 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FORC087_0924 ENOG4105F27 Major Facilitator FORC087_0925 ENOG4105WAB arsR family transcriptional regulator FORC087_093 ENOG4105DQ6 Transposase FORC087_0930 ENOG4108NIW Leucine export protein LeuE FORC087_0931 ENOG4105CMT Dihydroxyacetone kinase FORC087_0933 ENOG4105CMT Dihydroxyacetone kinase FORC087_0956 ENOG4105WN5 stage II sporulation protein FORC087_0958 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC087_0960 ENOG4108MJI response regulator FORC087_0961 ENOG4105BZU Histidine kinase FORC087_0962 ENOG4105BZU Histidine kinase FORC087_0967 ENOG4105K8R UPF0145 protein FORC087_0970 ENOG4105D7V transposase FORC087_0972 ENOG4107QHE Choloylglycine hydrolase FORC087_0977 ENOG4107VRP DNA repair exonuclease FORC087_0978 ENOG4106D4I domain protein FORC087_0985 ENOG4108MUZ hydrolase FORC087_0990 ENOG4105F0F Oxalate decarboxylase FORC087_0992 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FORC087_0995 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FORC087_0999 ENOG4105EMN RNA polymerase sigma factor FORC087_1001 ENOG4105CNI cell division protein FtsW FORC087_1002 ENOG4105EEM helicase FORC087_1003 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC087_1009 ENOG4105K59 histidine triad (HIT) protein FORC087_1016 ENOG410905X membrane-flanked domain protein FORC087_1017 ENOG4105CKV Membrane FORC087_1025 ENOG410905X membrane-flanked domain protein FORC087_1026 ENOG4105CKV Membrane FORC087_1027 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FORC087_1028 ENOG4105BZ4 penicillin-binding protein FORC087_1030 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FORC087_1031 ENOG4105C1Q protoporphyrinogen oxidase FORC087_1037 ENOG4105NA0 Transcriptional regulator FORC087_104 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC087_1040 ENOG4105ECB domain protein FORC087_1040 ENOG4105ECB domain protein FORC087_1046 ENOG4106AXD FORC087_1047 ENOG4108RQ5 Beta-lactamase domain-containing protein FORC087_1048 ENOG4105DF9 Lipoate-protein, ligase FORC087_1050 ENOG4105CEY Amp-dependent synthetase and ligase FORC087_1052 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FORC087_1053 ENOG4108I5D sulfate abc transporter FORC087_1054 ENOG4105ECW sulfate abc transporter FORC087_1055 ENOG4108IJ6 ABC transporter FORC087_106 ENOG4105D7V transposase FORC087_1076 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) FORC087_1079 ENOG4105ENX hydrolase FORC087_1080 ENOG4107RN3 metallophosphoesterase FORC087_1081 ENOG4107TVP HD domain protein FORC087_1083 ENOG4108AEY RNA polymerase sigma factor FORC087_1084 ENOG41086D8 Transcriptional regulator FORC087_1087 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC087_1091 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FORC087_1092 ENOG4105C8Q Methyl-accepting chemotaxis FORC087_1093 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) FORC087_1096 ENOG4107QP3 malate synthase g FORC087_1100 ENOG4105VEQ Cold shock protein FORC087_1117 ENOG4105ERH Fumarylacetoacetate hydrolase FORC087_1119 ENOG4105C8Y Acetylornithine aminotransferase FORC087_1123 ENOG4105CAQ asparagine synthetase FORC087_1124 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FORC087_1125 ENOG4105CH6 catalase FORC087_1133 ENOG4105BZU Histidine kinase FORC087_1139 ENOG4108VPT UPF0234 protein FORC087_1140 ENOG4105QNR S1 RNA binding domain protein FORC087_1141 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC087_1143 ENOG4107AYK membrAne FORC087_1144 ENOG41073B9 FORC087_1146 ENOG4108KP7 hydrolase FORC087_1148 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FORC087_1154 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FORC087_1155 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FORC087_1159 ENOG4105C31 Tryptophanyl-tRNA synthetase FORC087_1162 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FORC087_1163 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC087_1165 ENOG4108JQ7 (ABC) transporter FORC087_1166 ENOG4105UQX Mate efflux family protein FORC087_1170 ENOG4108ZCF integral membrane protein FORC087_1172 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FORC087_1174 ENOG4105DPN Oligoendopeptidase f FORC087_1177 ENOG4108Z18 K06886 hemoglobin FORC087_1178 ENOG4105MIX Adenylate cyclase FORC087_1179 ENOG4106EFP UPF0738 protein FORC087_1181 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FORC087_1182 ENOG4105EMS pseudouridine synthase FORC087_1186 ENOG4105K64 Glycosyl transferase, family 2 FORC087_1190 ENOG4107TVC Glycosyl transferase, family 2 FORC087_1194 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FORC087_1195 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FORC087_1197 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FORC087_1207 ENOG4108ZMI UPF0477 protein FORC087_121 ENOG4105CMG Carbohydrate kinase FORC087_1212 ENOG4105CK7 Sodium proline symporter FORC087_1214 ENOG4105CRQ synthase (Component I) FORC087_1215 ENOG4105DDQ anthranilate synthase FORC087_1217 ENOG4105DK0 Indole-3-glycerol phosphate synthase FORC087_123 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FORC087_1234 ENOG4105C7S Dehydrogenase FORC087_1235 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FORC087_1237 ENOG4105VZ8 Transcriptional regulator FORC087_1246 ENOG4105DZ1 carboxypeptidase FORC087_1247 ENOG4105VFR signal peptidase FORC087_1254 ENOG4105C26 Dehydrogenase FORC087_1255 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC087_1256 ENOG4105F38 ABC transporter, permease FORC087_1257 ENOG4105D38 putrescine abc transporter FORC087_1258 ENOG4107RUE extracellular solute-binding protein family 1 FORC087_1260 ENOG4105EYF MMPL domain protein FORC087_1262 ENOG4108YBP pseudouridine synthase FORC087_1264 ENOG4105K4I Scp-like extracellular FORC087_1265 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FORC087_1266 ENOG4105CQB FAD linked oxidase domain protein FORC087_1269 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC087_1270 ENOG4105BZU Histidine kinase FORC087_1271 ENOG4105JXH GntR family transcriptional regulator FORC087_1275 ENOG4106A3R peptidase FORC087_1277 ENOG4108QTI )-transporter FORC087_1278 ENOG4107TS3 membrane protein, TerC FORC087_1279 ENOG4105CZN Potassium uptake protein FORC087_1280 ENOG410681C small acid-soluble spore protein FORC087_1281 ENOG4108Z7G MaoC domain protein dehydratase FORC087_1285 ENOG4105CHR reductase FORC087_129 ENOG4105K4H Nlp p60 protein FORC087_1291 ENOG4105C4Y ABC transporter FORC087_1292 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC087_1293 ENOG4107RCV ABC transporter, permease FORC087_1297 ENOG4105E98 transcriptional regulator DeoR family FORC087_1300 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FORC087_1302 ENOG4105PXI polysaccharide deacetylase FORC087_1304 ENOG4105BZU Histidine kinase FORC087_1305 ENOG41090MY MarR family Transcriptional regulator FORC087_1307 ENOG4106DF1 FORC087_1310 ENOG4105BZU Histidine kinase FORC087_1311 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FORC087_1312 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FORC087_1313 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FORC087_1321 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FORC087_1322 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FORC087_1323 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FORC087_1325 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FORC087_1326 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FORC087_1327 ENOG4105CZV ABC transporter FORC087_1329 ENOG4105CJ1 ABC, transporter FORC087_1337 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FORC087_1339 ENOG4105EA8 2-Nitropropane dioxygenase FORC087_1340 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FORC087_1342 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FORC087_1347 ENOG4105NQC Flavodoxin FORC087_1361 ENOG4105CZN Potassium uptake protein FORC087_1362 ENOG41063Y9 FORC087_1363 ENOG4105KBJ sporulation protein ytfj FORC087_1368 ENOG4105CM2 brancheD-chain amino acid aminotransferase FORC087_1369 ENOG4105C7K acetolactate synthase FORC087_1370 ENOG4108ZP8 Acetolactate synthase small subunit FORC087_1371 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FORC087_1374 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FORC087_1377 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FORC087_1378 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FORC087_1379 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FORC087_1380 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FORC087_1381 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FORC087_1382 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FORC087_1385 ENOG4107RVV histidinol phosphate phosphatase, hisj family FORC087_1388 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FORC087_1389 ENOG4105E0M Sulfatase FORC087_1391 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FORC087_1394 ENOG4107S4M Sulfate adenylate transferase FORC087_1395 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FORC087_1396 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FORC087_1398 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FORC087_1399 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FORC087_1400 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FORC087_1401 ENOG4105C8J )-transporter FORC087_1406 ENOG4105DFD Na H antiporter FORC087_1410 ENOG4105ENE Histidine kinase FORC087_1411 ENOG4105WH1 Two component transcriptional regulator luxr family FORC087_1416 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FORC087_1421 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FORC087_1425 ENOG4105CJ3 phosphate transporter FORC087_1426 ENOG4107GRR phosphate transport regulator FORC087_1427 ENOG4105BZ4 penicillin-binding protein FORC087_1430 ENOG4105BZU Histidine kinase FORC087_1431 ENOG4105I3N Conserved Protein FORC087_1435 ENOG4105BZU Histidine kinase FORC087_1441 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FORC087_1442 ENOG4105DZ1 carboxypeptidase FORC087_1443 ENOG4108JIC nucleoside recognition domain protein FORC087_1446 ENOG4105FE9 pseudouridine synthase FORC087_1447 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC087_1448 ENOG4107TWT Cytochrome c biogenesis protein FORC087_1449 ENOG4105CRE cytochrome C FORC087_1450 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC087_1451 ENOG4105BZU Histidine kinase FORC087_1452 ENOG4108WBT adenosyltransferase FORC087_1455 ENOG4108SAX Membrane FORC087_1458 ENOG4105C9U ATP-dependent DNA helicase RecQ FORC087_1459 ENOG4105I7S Abortive infection protein FORC087_1461 ENOG4107RGJ metallophosphoesterase FORC087_1462 ENOG4108XDN Transcriptional regulator FORC087_1463 ENOG4108S6Z Negative regulator of genetic competence FORC087_1468 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FORC087_1469 ENOG4107RB3 L-asparaginase FORC087_1473 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FORC087_1476 ENOG4105S2F FORC087_1477 ENOG41065D1 FORC087_1483 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FORC087_1486 ENOG4105XXQ heptaprenyl diphosphate synthase component I FORC087_1488 ENOG4105EAH synthase FORC087_1489 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FORC087_1490 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FORC087_1493 ENOG41068YB TPR repeat-containing protein FORC087_1496 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FORC087_1497 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FORC087_1504 ENOG4108JYZ YitT family FORC087_1505 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FORC087_1508 ENOG4105FJR Lmbe family FORC087_1509 ENOG4105CPK Glycosyl transferase (Group 1 FORC087_1513 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FORC087_1516 ENOG4105DVT helicase FORC087_1517 ENOG4105YAC FORC087_1521 ENOG4105CSM endonuclease III FORC087_1523 ENOG4105BZ4 penicillin-binding protein FORC087_1532 ENOG4106F55 Protein of unknown function (DUF1273) FORC087_1534 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FORC087_1536 ENOG4105DVT helicase FORC087_1537 ENOG4105CTD carboxy-peptidase FORC087_1539 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FORC087_1541 ENOG4105C2W permease FORC087_1542 ENOG4105DHF Membrane FORC087_1544 ENOG410890F Dynamin family FORC087_1546 ENOG4108W0I acetyltransferase FORC087_1548 ENOG4105KHC sulfurtransferase FORC087_155 ENOG4105D7V transposase FORC087_1557 ENOG4105HTX biosynthesis protein FORC087_1563 ENOG4105CPK Glycosyl transferase (Group 1 FORC087_1566 ENOG4108SZE gCN5-related N-acetyltransferase FORC087_1570 ENOG41081VK Ribonuclease FORC087_1583 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FORC087_1585 ENOG4107RWR Sodium hydrogen exchanger FORC087_1586 ENOG4105CN5 Metallo-Beta-Lactamase FORC087_1587 ENOG4108Z5V transcriptional regulator, merr family FORC087_1589 ENOG4105H67 Protein of unknown function (DUF421) FORC087_1590 ENOG41080C8 DUF218 domain FORC087_1599 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FORC087_1601 ENOG4107R0U MotA TolQ exbB proton channel FORC087_1602 ENOG4105ER2 Ompa motb domain protein FORC087_1603 ENOG4107YTP response regulator receiver protein FORC087_1604 ENOG4105CBS Chea signal transduction histidine kinase FORC087_1605 ENOG4105DD5 Flagellar motor switch protein FORC087_1608 ENOG4105BZU Histidine kinase FORC087_1612 ENOG4105E1Q flagellar hook-associated protein FORC087_1613 ENOG4105DTJ flagellar hook-associated protein FORC087_1617 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FORC087_1618 ENOG4108ZC9 flagellar basal-body rod protein flgc FORC087_1619 ENOG41075Z6 flagellar hook-basal body complex protein fliE FORC087_1620 ENOG4107U2N Flagellar M-ring protein FORC087_1621 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FORC087_1627 ENOG4105BZE flagellar hook protein, FlgE FORC087_1630 ENOG4107R88 Chemotaxis protein (CheV) FORC087_1632 ENOG4105I03 Flagellin FORC087_1633 ENOG4105I03 Flagellin FORC087_1634 ENOG4105E4C Lytic transglycosylase catalytic FORC087_1636 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FORC087_1637 ENOG4105DD5 Flagellar motor switch protein FORC087_1639 ENOG4105CN7 Flagellar biosynthetic protein FliP FORC087_1640 ENOG4105VS8 Flagellar biosynthetic protein fliq FORC087_1642 ENOG4105D00 flagellar biosynthetic protein flhB FORC087_1643 ENOG4105D7B Flagellar biosynthesis protein flha FORC087_1644 ENOG4105FZW flagellar biosynthesis regulator FlhF FORC087_1645 ENOG4105KTQ flagellar basal-body rod protein FORC087_1646 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FORC087_1654 ENOG4105KAC Antibiotic biosynthesis monooxygenase FORC087_1659 ENOG4105DUM transcriptional regulator, lysR family FORC087_1660 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC087_1661 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FORC087_1662 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FORC087_1669 ENOG4105CVJ phosphoglycerate mutase FORC087_1671 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FORC087_1675 ENOG4105CAQ asparagine synthetase FORC087_1679 ENOG4105PGM cation diffusion facilitator family transporter FORC087_168 ENOG4105CNU cell division protein FtsK FORC087_1681 ENOG4105DRR Transcriptional regulator, GntR family FORC087_1682 ENOG4108UZ3 Transporter FORC087_1684 ENOG4105CKI cobalamin synthesis protein FORC087_1685 ENOG4108PJD permease FORC087_1688 ENOG4105DFD Na H antiporter FORC087_1689 ENOG4105VUF Transcriptional regulator FORC087_1691 ENOG4105C9Q fumarate hydratase class II FORC087_1695 ENOG4107QJQ Mate efflux family protein FORC087_1696 ENOG4105EC3 peptidase S51, dipeptidase E FORC087_1701 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC087_1704 ENOG4107JM4 Tetratricopeptide repeat FORC087_1708 ENOG4106BRA Membrane FORC087_171 ENOG4105EXC Acyl-transferase FORC087_1715 ENOG4105CJ1 ABC, transporter FORC087_1720 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FORC087_1724 ENOG4108IJ0 Aspartate ammonia-lyase FORC087_1725 ENOG4105C6K Malic enzyme FORC087_1738 ENOG4105FVX FORC087_1739 ENOG4105E09 nadh pyrophosphatase FORC087_1742 ENOG4105CSR polyphosphate kinase 2 FORC087_1743 ENOG4105U3E Transcriptional regulator FORC087_1745 ENOG4105DXI Major Facilitator superfamily FORC087_1747 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FORC087_1748 ENOG4105EU0 Major facilitator Superfamily FORC087_1749 ENOG4105C6T cysteine synthase FORC087_175 ENOG4108W0I acetyltransferase FORC087_1753 ENOG4105C8J )-transporter FORC087_1755 ENOG4105X5K response regulator receiver protein FORC087_1756 ENOG4105H67 Protein of unknown function (DUF421) FORC087_176 ENOG4107QQG Dehydrogenase FORC087_1761 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FORC087_1762 ENOG4105CHR reductase FORC087_1763 ENOG4105CM2 brancheD-chain amino acid aminotransferase FORC087_1764 ENOG4105C7K acetolactate synthase FORC087_1766 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FORC087_1767 ENOG4105C01 Dihydroxy-acid dehydratase FORC087_1768 ENOG4105C7B Threonine dehydratase FORC087_177 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FORC087_1773 ENOG4105C6X Major Facilitator FORC087_1774 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FORC087_1776 ENOG4105DY9 regulatoR FORC087_1777 ENOG4105CYC Transferase FORC087_1778 ENOG4105K5X acetyltransferase FORC087_178 ENOG4108IAJ Nad-dependent epimerase dehydratase FORC087_1782 ENOG41068WN FORC087_1783 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FORC087_1786 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FORC087_1788 ENOG4105C0X amino acid FORC087_179 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FORC087_1794 ENOG4105K8R UPF0145 protein FORC087_1798 ENOG4107RHR regulatoR FORC087_1800 ENOG4105D9N nucleoside FORC087_1801 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FORC087_1809 ENOG4107RAQ aminopeptidase FORC087_1811 ENOG4107R16 Multicopper oxidase FORC087_1819 ENOG4108T5E Copper resistance protein FORC087_182 ENOG4105FJR Lmbe family FORC087_1820 ENOG4105KTB nuclear export factor GLE1 FORC087_1821 ENOG4107RT3 EamA-like transporter family FORC087_1822 ENOG4105GZI Transcriptional regulator FORC087_1823 ENOG4108Z40 Transcriptional regulator FORC087_1824 ENOG4107ZXU DSBA oxidoreductase FORC087_1825 ENOG4108TVJ Nitroreductase FORC087_1827 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FORC087_1828 ENOG4106F5Q Membrane FORC087_1829 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FORC087_1832 ENOG4105CKI cobalamin synthesis protein FORC087_1834 ENOG4105C0Z ABC transporter FORC087_1835 ENOG4108IV0 ABC, transporter FORC087_1838 ENOG4105SKE transcriptional Regulator LysR family FORC087_184 ENOG4105IIU Aminopeptidase FORC087_1840 ENOG4105MDS 4-oxalocrotonate tautomerase FORC087_1844 ENOG4105C4M (Ubiquinol oxidase) subunit I FORC087_1845 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FORC087_1846 ENOG4108JJ9 ABC, transporter FORC087_1847 ENOG4108JJ8 (ABC) transporter FORC087_1849 ENOG4105K64 Glycosyl transferase, family 2 FORC087_185 ENOG4108SC4 )-transporter FORC087_1851 ENOG4108UT6 Transferase hexapeptide repeat containing protein FORC087_1862 ENOG4105BZ1 (ABC) transporter FORC087_1863 ENOG4105EFI regulatoR FORC087_1864 ENOG4105BZU Histidine kinase FORC087_1866 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FORC087_1867 ENOG4108ZJ4 polysaccharide deacetylase FORC087_1871 ENOG4105D6E homoserine dehydrogenase FORC087_1873 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FORC087_1876 ENOG4108KGH TRANSCRIPTIONal FORC087_1878 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC087_1879 ENOG4105BZU Histidine kinase FORC087_1880 ENOG4107VMI polysaccharide deacetylase FORC087_1882 ENOG4105KT7 mgtC SapB transporter FORC087_1883 ENOG4105VRR gCN5-related N-acetyltransferase FORC087_1885 ENOG4105DUU IucA IucC family protein FORC087_1886 ENOG4105CEY Amp-dependent synthetase and ligase FORC087_1889 ENOG4108WBH protein TIM barrel FORC087_1890 ENOG4105YWU small acid-soluble spore protein FORC087_1892 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FORC087_1893 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC087_1903 ENOG4105KRN Transcriptional regulator, abrb family FORC087_1907 ENOG4105KAF membrAne FORC087_1912 ENOG4105C8Q Methyl-accepting chemotaxis FORC087_1915 ENOG4108K88 Membrane FORC087_1916 ENOG4108WPJ Ferritin-like domain FORC087_1919 ENOG4105DEN Luciferase family FORC087_1922 ENOG4105VMI -acetyltransferase FORC087_1923 ENOG4107QM2 Aldo Keto reductase FORC087_1924 ENOG4105CKI cobalamin synthesis protein FORC087_1926 ENOG4105DSE periplasmic solute binding protein FORC087_1928 ENOG4105K4T epimerase FORC087_1930 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FORC087_1939 ENOG4107T5V SNARE associated Golgi FORC087_1942 ENOG4108PJD permease FORC087_1944 ENOG4108S4H thioesterase Superfamily protein FORC087_1947 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FORC087_1951 ENOG4105SXS Protein of unknown function (DUF456) FORC087_1952 ENOG4105C37 (CBS) domain FORC087_1956 ENOG4108Z7R Chaperone CsaA FORC087_1959 ENOG4108ZRV stage ii sporulation protein p FORC087_1961 ENOG4108VXD carboxy-peptidase FORC087_1963 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FORC087_1967 ENOG4108ZRV stage ii sporulation protein p FORC087_1969 ENOG4108X4Q Hydrolase FORC087_1972 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FORC087_1975 ENOG41087PP glycosyltransferase MGT family FORC087_1976 ENOG4108JYZ YitT family FORC087_1977 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC087_1983 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FORC087_1987 ENOG4106PAW secretion accessory protein EsaA YueB FORC087_1989 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) FORC087_1990 ENOG4108MGT Required for secretion of EsxA and EsxB FORC087_2004 ENOG4105KBJ sporulation protein ytfj FORC087_2009 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FORC087_2013 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) FORC087_2014 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FORC087_2016 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FORC087_2017 ENOG4105EMN RNA polymerase sigma factor FORC087_2022 ENOG4108V06 Glutathione peroxidase FORC087_2025 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FORC087_2033 ENOG4105MCT stage V sporulation protein S FORC087_204 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FORC087_2043 ENOG4105C5H ABC transporter FORC087_2046 ENOG4108UUM single-stranded DNA-binding protein FORC087_2056 ENOG4105E5W Transporter FORC087_2065 ENOG4105K5B UPF0225 protein FORC087_2078 ENOG4107YX5 Pfam:DUF548 FORC087_2079 ENOG4105C75 arginyL-tRNA synthetase FORC087_2083 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FORC087_2088 ENOG4105C5S asparaginyl-tRNA synthetase FORC087_2089 ENOG4105C8J )-transporter FORC087_2094 ENOG4105CY2 Citrate transporter FORC087_2098 ENOG4105KD7 acetyltransferase FORC087_2100 ENOG4105VMP Transcriptional regulator FORC087_2101 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FORC087_2106 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FORC087_2109 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FORC087_2110 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FORC087_2112 ENOG4107RVG penicillin-binding protein FORC087_2113 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FORC087_2114 ENOG4105E9Q Acyl-transferase FORC087_2115 ENOG4108UT2 hemolysin iii FORC087_2117 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FORC087_2119 ENOG4108RCR degv family FORC087_2122 ENOG4108KF3 Electron transport protein SCO1 SenC FORC087_2123 ENOG4107Y70 Heat shock protein FORC087_2124 ENOG4105CAQ asparagine synthetase FORC087_2127 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FORC087_2128 ENOG4108MES Periplasmic binding protein FORC087_2129 ENOG4105F0I Aminotransferase FORC087_2135 ENOG4105D8X mechanosensitive ion channel FORC087_2136 ENOG4105BZU Histidine kinase FORC087_2137 ENOG4105WH1 Two component transcriptional regulator luxr family FORC087_2138 ENOG4106KNT transcriptional regulator FORC087_2139 ENOG4107ZY0 Phenazine biosynthesis-like protein FORC087_2143 ENOG4105CMG Carbohydrate kinase FORC087_2144 ENOG4105CMG Carbohydrate kinase FORC087_2145 ENOG4105C6Z Gluconate FORC087_2147 ENOG4108YV3 Protein of unknown function (DUF2711) FORC087_2153 ENOG4108IJ8 ABC transporter FORC087_2154 ENOG4105E90 ABC transporter FORC087_2161 ENOG4105C37 (CBS) domain FORC087_2166 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FORC087_2169 ENOG4107S4Y M20 DapE family protein YgeY FORC087_2170 ENOG4108TSC N-acetyltransferase FORC087_2171 ENOG4108JUB Transcriptional regulator FORC087_2172 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FORC087_2182 ENOG410841Q phosphoesterase PA-phosphatase related protein FORC087_2183 ENOG4105SZ6 Thioredoxin FORC087_2191 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC087_2203 ENOG4105BZ4 penicillin-binding protein FORC087_2205 ENOG4105CZM Major Facilitator FORC087_2206 ENOG4105W8X HesB YadR YfhF-family protein FORC087_2208 ENOG4105DXD 2-methylcitrate dehydratase FORC087_2209 ENOG4105CR4 methylisocitrate lyase FORC087_2210 ENOG4105C1G acyl-Coa dehydrogenase FORC087_2211 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FORC087_2213 ENOG4105N14 lysine exporter protein LysE YggA FORC087_2214 ENOG4105E39 Enoyl-CoA hydratase FORC087_2217 ENOG4107RFY SbcCD D subunit FORC087_2218 ENOG4105EYH Exonuclease FORC087_2223 ENOG4105FCD Major Facilitator FORC087_2224 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FORC087_2225 ENOG4105E4F Isochorismate synthase FORC087_2226 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FORC087_2227 ENOG4105WQI isochorismatase FORC087_2228 ENOG4105CEY Amp-dependent synthetase and ligase FORC087_2229 ENOG4105WQT MbtH domain protein FORC087_2230 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC087_2233 ENOG4105K70 DNA-binding protein FORC087_2237 ENOG4105BZG amino acid carrier protein FORC087_2241 ENOG4105FE9 pseudouridine synthase FORC087_2242 ENOG4105C22 threonyL-tRNA synthetase FORC087_2243 ENOG4105C19 ABC transporter FORC087_2252 ENOG41081I9 integral membrane protein FORC087_2254 ENOG4108Y4K DNA-binding transcriptional activator FORC087_2258 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FORC087_2260 ENOG4105EYF MMPL domain protein FORC087_2265 ENOG4105WCN acetyltransferase FORC087_2270 ENOG4105C1Q protoporphyrinogen oxidase FORC087_2272 ENOG41068WN FORC087_2278 ENOG4107V2S Transcriptional regulator FORC087_2279 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FORC087_2283 ENOG4105DND Transcriptional regulator FORC087_2284 ENOG4108RPX mosc domain containing protein FORC087_2287 ENOG4105BZ1 (ABC) transporter FORC087_2288 ENOG4105BZ1 (ABC) transporter FORC087_2295 ENOG4108JCI Transcriptional regulator FORC087_2302 ENOG4108QDE fad dependent oxidoreductase FORC087_2308 ENOG4105F32 YngK protein FORC087_2314 ENOG4105RD7 BadF BadG BcrA BcrD FORC087_2315 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FORC087_2316 ENOG4107STF Involved in phosphonate degradation (By similarity) FORC087_2317 ENOG4105C7B Threonine dehydratase FORC087_2318 ENOG4108INS Transcriptional regulator FORC087_2322 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FORC087_2324 ENOG4105C1J atp-dependent rna helicase FORC087_2329 ENOG4108RZE Tetr family transcriptional regulator FORC087_2335 ENOG41088CC tellurite resistance protein tehB FORC087_2337 ENOG4108I0C methyltransferase FORC087_2338 ENOG4107RA9 decarboxylase FORC087_2339 ENOG4105K56 Transcriptional regulator FORC087_2340 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FORC087_2345 ENOG4105CIN aminoacyl-histidine dipeptidase FORC087_2350 ENOG4105KRN Transcriptional regulator, abrb family FORC087_2352 ENOG4105EJ9 Membrane FORC087_2353 ENOG4105EQK -acetyltransferase FORC087_2363 ENOG4105CHR reductase FORC087_2375 ENOG4108IMY Transcriptional regulator FORC087_2378 ENOG4107VMI polysaccharide deacetylase FORC087_2379 ENOG4108RZE Tetr family transcriptional regulator FORC087_2380 ENOG4105CAQ asparagine synthetase FORC087_2390 ENOG4105EJQ L-serine dehydratase FORC087_2391 ENOG4105C44 Serine transporter FORC087_2396 ENOG4105F6S Spore photoproduct lyase FORC087_2399 ENOG4105CVK Glutamate decarboxylase FORC087_2400 ENOG4107QHE Choloylglycine hydrolase FORC087_2402 ENOG4108NHD germination protein FORC087_2403 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FORC087_2404 ENOG4105CNI cell division protein FtsW FORC087_2405 ENOG4105CJW magnesium transporter FORC087_2407 ENOG4107RVG penicillin-binding protein FORC087_2410 ENOG4107RF6 penicillin-binding protein FORC087_2411 ENOG4107RF6 penicillin-binding protein FORC087_2413 ENOG4105DIN metallophosphoesterase FORC087_2415 ENOG4105CJ1 ABC, transporter FORC087_2418 ENOG4107Z3H Transcriptional regulator, TetR family FORC087_2421 ENOG4105C1G acyl-Coa dehydrogenase FORC087_2422 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FORC087_2423 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FORC087_2424 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FORC087_2425 ENOG4105E39 Enoyl-CoA hydratase FORC087_2426 ENOG4107QX3 carboxylase FORC087_2427 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FORC087_2432 ENOG4105DBI uridine monophosphokinase FORC087_2435 ENOG4105DZ1 carboxypeptidase FORC087_2438 ENOG4105T9C HD domain FORC087_2440 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FORC087_2444 ENOG41075H3 AraC family transcriptional regulator FORC087_2450 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FORC087_2455 ENOG4107Y80 Major Facilitator superfamily FORC087_2456 ENOG4105KVH Transcriptional regulator FORC087_2457 ENOG41089UC methyltransferase, type 11 FORC087_2467 ENOG4105EFA 4-hydroxyphenylacetate FORC087_2472 ENOG410900G Protein of unknown function (DUF421) FORC087_2473 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FORC087_2475 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FORC087_2489 ENOG4105D6E homoserine dehydrogenase FORC087_2491 ENOG4105CPF Cell wall formation (By similarity) FORC087_2492 ENOG4105ETU transcriptional activator (TenA FORC087_2498 ENOG4105VTR Integrase FORC087_2511 ENOG4105KRN Transcriptional regulator, abrb family FORC087_252 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein FORC087_253 ENOG4105D9U N-acetyltransferase FORC087_2531 ENOG410682Q Phage transcriptional regulator, ArpU FORC087_2539 ENOG4105CAR Terminase, large subunit FORC087_254 ENOG4105K70 DNA-binding protein FORC087_2542 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FORC087_2555 ENOG4105XSJ toxin secretion phage lysis holin FORC087_2574 ENOG410667J hydrolase FORC087_2575 ENOG4105BZU Histidine kinase FORC087_2576 ENOG4107RF6 penicillin-binding protein FORC087_2581 ENOG4108JJB ABC transporter FORC087_2584 ENOG4108HGU Histidine kinase FORC087_2585 ENOG4105VTR Integrase FORC087_2598 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC087_2599 ENOG4105GR3 Histidine kinase FORC087_2600 ENOG4105CB2 alcohol dehydrogenase FORC087_2601 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FORC087_2602 ENOG4105CJN penicillin-binding protein FORC087_2610 ENOG4107SWG transcriptional regulator MERR family FORC087_2611 ENOG4108Z6Z Transcriptional regulator FORC087_2616 ENOG4105F27 Major Facilitator FORC087_2617 ENOG4107Y80 Major Facilitator superfamily FORC087_2622 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FORC087_2626 ENOG4107Y9U Membrane FORC087_2630 ENOG4105EGD dinuclear metal center protein, YbgI family FORC087_2635 ENOG4105FCD Major Facilitator FORC087_2637 ENOG4105E09 nadh pyrophosphatase FORC087_2638 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FORC087_2644 ENOG4108XI2 Domain of unknown function (DUF1963) FORC087_2651 ENOG4105KWG Pfam:DUF1696 FORC087_2653 ENOG4108YYS metal-dependent hydrolase (By similarity) FORC087_2656 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FORC087_2658 ENOG4105PKS Excinuclease abc c subunit domain protein FORC087_2667 ENOG4107VFR oxidoreductase FORC087_267 ENOG4105E39 Enoyl-CoA hydratase FORC087_2673 ENOG4105U0R haloacid dehalogenase-like hydrolase FORC087_2675 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC087_2676 ENOG4105BZU Histidine kinase FORC087_268 ENOG4105K64 Glycosyl transferase, family 2 FORC087_2680 ENOG4107WD8 ABC transporter, permease FORC087_2683 ENOG4108IUM Glycogen debranching enzyme FORC087_2685 ENOG4105CGH 5'-nucleotidase FORC087_2689 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FORC087_2690 ENOG4105FDR Membrane FORC087_2691 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC087_270 ENOG4108UT6 Transferase hexapeptide repeat containing protein FORC087_2702 ENOG4105MSI germination protein ypeb FORC087_2708 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) FORC087_2709 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FORC087_2710 ENOG4107Z3H Transcriptional regulator, TetR family FORC087_2717 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FORC087_2721 ENOG4105E98 transcriptional regulator DeoR family FORC087_2724 ENOG41062ES Transcriptional regulator FORC087_2728 ENOG4107QKR Dehydrogenase FORC087_2730 ENOG4107RUY (E1 component), alpha subunit FORC087_2733 ENOG4105JHE Major Facilitator Superfamily FORC087_2735 ENOG4105E1F short-chain dehydrogenase reductase FORC087_2741 ENOG4107SQ8 Glycine betaine FORC087_2742 ENOG4108IJ7 Glycine betaine FORC087_2747 ENOG4105E66 phosphoriboisomerase A FORC087_2748 ENOG41082BV acetyltransferase FORC087_2749 ENOG4108M1A Chitin-binding protein FORC087_2750 ENOG41087PP glycosyltransferase MGT family FORC087_2755 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FORC087_2756 ENOG4105MSB protein, conserved in bacteria FORC087_2761 ENOG4108Z7F N-acetyltransferase FORC087_2767 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FORC087_2768 ENOG4105EEM helicase FORC087_277 ENOG4105D7V transposase FORC087_2770 ENOG41066HZ AIG2-like family FORC087_2771 ENOG4105C9U ATP-dependent DNA helicase RecQ FORC087_2783 ENOG4108M1A Chitin-binding protein FORC087_2786 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FORC087_2788 ENOG4105BZG amino acid carrier protein FORC087_2789 ENOG4105C26 Dehydrogenase FORC087_2790 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FORC087_2791 ENOG4105CTU Proline racemase FORC087_2792 ENOG4105CTU Proline racemase FORC087_2793 ENOG41080HI glycine oxidase FORC087_2795 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FORC087_2801 ENOG4107T5V SNARE associated Golgi FORC087_2803 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FORC087_2807 ENOG4105DTQ mandelate racemase muconate lactonizing FORC087_2810 ENOG4107SET aldo keto reductase FORC087_2819 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FORC087_2821 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC087_2822 ENOG4105BZU Histidine kinase FORC087_2823 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC087_2827 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 FORC087_2831 ENOG4105DPN Oligoendopeptidase f FORC087_2832 ENOG4105EPR degv family FORC087_284 ENOG4105ETE Transcriptional regulator (LacI family FORC087_2846 ENOG4106K7D Major facilitator family transporter FORC087_285 ENOG4105IE8 Alpha-ketoglutarate permease FORC087_2851 ENOG4107BMA Transglycosylase associated protein FORC087_2854 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FORC087_286 ENOG4105CK5 oxidoreductase FORC087_2863 ENOG4105CHM Aminotransferase FORC087_2866 ENOG4108ZMI UPF0477 protein FORC087_2869 ENOG4105DVE abc transporter atp-binding protein FORC087_2880 ENOG4105C02 permease FORC087_2883 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FORC087_2884 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FORC087_2885 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FORC087_2886 ENOG4105D7T ABC transporter FORC087_2892 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FORC087_2900 ENOG4107VC0 DNA alkylation repair enzyme FORC087_2902 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FORC087_2904 ENOG4107VMI polysaccharide deacetylase FORC087_2905 ENOG4108ZCF integral membrane protein FORC087_2906 ENOG4105E0M Sulfatase FORC087_2908 ENOG4105C5H ABC transporter FORC087_291 ENOG4105D2N Aldolase FORC087_2910 ENOG4105EYF MMPL domain protein FORC087_2911 ENOG41082JN Transcriptional regulator FORC087_2917 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FORC087_2918 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FORC087_292 ENOG4105DH8 myo-inositol catabolism FORC087_2927 ENOG41069ER domain protein FORC087_2929 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FORC087_2930 ENOG4105DNP FAD linked oxidase domain protein FORC087_2935 ENOG4105D4B ABC, transporter FORC087_2936 ENOG4105F5R ABC transporter FORC087_2939 ENOG4105DKT Transcriptional regulator FORC087_2940 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) FORC087_2942 ENOG41061GT Aldolase FORC087_2944 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FORC087_2950 ENOG4105II7 pyrroline-5-carboxylate reductase FORC087_2952 ENOG4107258 Transcriptional regulator FORC087_2956 ENOG4105ECK Fatty Acid Desaturase FORC087_2958 ENOG4107RBI VanW family FORC087_2959 ENOG4105G6Z alkaline phosphatase FORC087_2961 ENOG4105VMP Transcriptional regulator FORC087_2965 ENOG41068WN FORC087_2971 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FORC087_2976 ENOG4105CKK Glycosyl transferase, family 2 FORC087_2981 ENOG4105C8Y Acetylornithine aminotransferase FORC087_2990 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FORC087_2998 ENOG41090AA FORC087_2999 ENOG4108IBT Inherit from COG: transposase FORC087_3003 ENOG4108TVJ Nitroreductase FORC087_3004 ENOG4105FS7 Transcriptional regulator FORC087_3007 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FORC087_3014 ENOG4108XET gCN5-related N-acetyltransferase FORC087_3017 ENOG4108PCN EamA-like transporter family FORC087_3019 ENOG4107XJU UPF0178 protein FORC087_3026 ENOG410635A Membrane FORC087_3028 ENOG4108IQI permease FORC087_3031 ENOG4105F1N DNA alkylation repair FORC087_3038 ENOG4107RF6 penicillin-binding protein FORC087_3039 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FORC087_3043 ENOG4105E7W lamb ycsf family protein FORC087_3045 ENOG4105P4J Allophanate hydrolase, subunit 1 FORC087_3046 ENOG4107258 Transcriptional regulator FORC087_3048 ENOG4106N3A copper homeostasis protein cutc FORC087_3050 ENOG4108ZHR arsR family transcriptional regulator FORC087_3052 ENOG4105FDT acyl-CoA dehydrogenase FORC087_3056 ENOG4105DWD nucleoside recognition domain protein FORC087_3064 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FORC087_3069 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FORC087_3074 ENOG4105E2A Dehydrogenase FORC087_3076 ENOG4108IJ0 Aspartate ammonia-lyase FORC087_3077 ENOG4105HDK L-asparaginase FORC087_3078 ENOG4108IMY Transcriptional regulator FORC087_3080 ENOG4108B31 Spore germination protein FORC087_3082 ENOG4105BZU Histidine kinase FORC087_3087 ENOG41075H3 AraC family transcriptional regulator FORC087_3090 ENOG4105YWU small acid-soluble spore protein FORC087_3091 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FORC087_3092 ENOG4105CUB amino acid FORC087_3093 ENOG4105II7 pyrroline-5-carboxylate reductase FORC087_3094 ENOG4108NHD germination protein FORC087_3095 ENOG4108Q8B Spore germination protein FORC087_3106 ENOG4105CGH 5'-nucleotidase FORC087_3109 ENOG4105CHJ isochorismatase hydrolase FORC087_3113 ENOG4107RSM transcriptional regulator FORC087_3114 ENOG4105EQ0 Major Facilitator superfamily FORC087_3123 ENOG4105F6J Alpha beta hydrolase fold FORC087_3126 ENOG4108606 TspO/MBR family FORC087_3127 ENOG4105CVP deoxyribo-dipyrimidine photolyase FORC087_3130 ENOG4108TWJ NADH dehydrogenase subunit 5 FORC087_3131 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FORC087_3135 ENOG4107VMI polysaccharide deacetylase FORC087_3137 ENOG4105BZU Histidine kinase FORC087_3138 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC087_3144 ENOG4108VJ1 Transcriptional regulator (CarD family FORC087_3147 ENOG4105FR1 rard protein FORC087_3151 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FORC087_3152 ENOG4105ECQ AraC Family Transcriptional Regulator FORC087_3156 ENOG4105D6J arsenicaL-resistance protein FORC087_3157 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FORC087_3158 ENOG41085FC arsR family transcriptional regulator FORC087_3160 ENOG4105NAE bifunctional deaminase-reductase domain protein FORC087_3161 ENOG4107P5I polyketide synthase FORC087_3162 ENOG4108IG5 Transcriptional regulator FORC087_3163 ENOG4108JGH Tetr family transcriptional regulator FORC087_3164 ENOG4105EQ0 Major Facilitator superfamily FORC087_3168 ENOG4105F27 Major Facilitator FORC087_3169 ENOG4105M4P Tetr family transcriptional regulator FORC087_3170 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FORC087_3171 ENOG4108YXU transcriptional regulator AsnC family FORC087_3178 ENOG4105DQ6 Transposase FORC087_3180 ENOG4105N0V mono-oxygenase ydhR FORC087_3195 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FORC087_3196 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC087_3199 ENOG4105K6H D-cysteine desulfhydrase FORC087_3201 ENOG4105E0Y RtcB Protein FORC087_3203 ENOG4105JQZ Methyltransferase FORC087_3207 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FORC087_3208 ENOG4105BZU Histidine kinase FORC087_3210 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FORC087_3218 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FORC087_3225 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FORC087_323 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FORC087_3242 ENOG4108VXD carboxy-peptidase FORC087_3243 ENOG4105PNM synthesis protein FORC087_3245 ENOG4108ISG Major Facilitator FORC087_3248 ENOG4107MII Sugar-specific transcriptional regulator TrmB FORC087_3249 ENOG4105CZM Major Facilitator FORC087_3252 ENOG4105CRW Short chain fatty acid transporter FORC087_3254 ENOG4105DYS nad(p)h dehydrogenase (quinone) FORC087_3266 ENOG4108K8S endonuclease I FORC087_3270 ENOG4108Z66 YbaK ebsC protein FORC087_3272 ENOG4105KVH Transcriptional regulator FORC087_3273 ENOG4108RCM Nitroreductase FORC087_3279 ENOG4108PSK reductase FORC087_3293 ENOG4105C31 Tryptophanyl-tRNA synthetase FORC087_3294 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FORC087_3300 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) FORC087_3302 ENOG4105EV4 Multidrug resistance protein mdtH FORC087_3308 ENOG4105C37 (CBS) domain FORC087_3311 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FORC087_3312 ENOG4105FAW cDP-glucose 4,6-dehydratase FORC087_3319 ENOG4105DDN Pentapeptide repeat-containing protein FORC087_332 ENOG4105D7V transposase FORC087_3320 ENOG4105XDF Protein of unknown function (DUF1272) FORC087_3321 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FORC087_3322 ENOG4105CMG Carbohydrate kinase FORC087_3323 ENOG4105C6Z Gluconate FORC087_3324 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FORC087_3327 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FORC087_3331 ENOG4105C8Q Methyl-accepting chemotaxis FORC087_3333 ENOG4108UX3 '-nucleotidase FORC087_3334 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FORC087_3335 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) FORC087_3336 ENOG4105KVH Transcriptional regulator FORC087_3342 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FORC087_3344 ENOG4105CHH sulfate transporter FORC087_3347 ENOG4105C44 Serine transporter FORC087_3352 ENOG4108TZY GntR Family Transcriptional Regulator FORC087_3353 ENOG4105D9R oxidoreductase FORC087_336 ENOG4105E1K spore germination protein FORC087_3361 ENOG4105JAB phenazine biosynthesis protein, phzf family FORC087_3364 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FORC087_3365 ENOG4105KVH Transcriptional regulator FORC087_3368 ENOG4108ZJ4 polysaccharide deacetylase FORC087_338 ENOG4108M1A Chitin-binding protein FORC087_3381 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FORC087_3387 ENOG4105H3G oxidoreductase FORC087_339 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C FORC087_3401 ENOG4108TN2 lmbE family FORC087_3403 ENOG4107R3E Citrate transporter FORC087_3405 ENOG4105WCN acetyltransferase FORC087_3406 ENOG4108MES Periplasmic binding protein FORC087_3407 ENOG4105EHG Permease protein FORC087_3408 ENOG4105DQ5 transport system permease protein FORC087_3413 ENOG41068WN FORC087_3414 ENOG4107CUJ Protein of unknown function (DUF2690) FORC087_3416 ENOG4107V2S Transcriptional regulator FORC087_3418 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FORC087_3421 ENOG4105C98 muts2 protein FORC087_3422 ENOG4105E5K Alpha-amylase FORC087_3423 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FORC087_3424 ENOG4105DPN Oligoendopeptidase f FORC087_3425 ENOG4108A04 Beta-lactamase FORC087_343 ENOG4105CJZ response regulator FORC087_3430 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FORC087_3433 ENOG41082BM Transcriptional regulator, arsr family FORC087_3434 ENOG4105CIS alcohol dehydrogenase FORC087_3439 ENOG4105RHY Pfam:UPF0157 FORC087_3442 ENOG4105CQB FAD linked oxidase domain protein FORC087_3446 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FORC087_3449 ENOG4107TPS domain protein FORC087_345 ENOG4105BZU Histidine kinase FORC087_3450 ENOG4105CEP NADH dehydrogenase FORC087_3452 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FORC087_3454 ENOG4108IAJ Nad-dependent epimerase dehydratase FORC087_3455 ENOG4105FAW cDP-glucose 4,6-dehydratase FORC087_346 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC087_3469 ENOG4105BZU Histidine kinase FORC087_3471 ENOG4105C5H ABC transporter FORC087_3475 ENOG4105BZU Histidine kinase FORC087_3477 ENOG4105KT7 mgtC SapB transporter FORC087_3479 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FORC087_3480 ENOG41073R8 VanW family FORC087_3482 ENOG4108R1P FORC087_3486 ENOG4105VEQ Cold shock protein FORC087_349 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FORC087_3491 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FORC087_3495 ENOG410904N short-chain dehydrogenase reductase FORC087_3497 ENOG4106IQC argininosuccinate lyase FORC087_3500 ENOG4108IA2 Sodium pantothenate symporter FORC087_3502 ENOG4105C26 Dehydrogenase FORC087_3503 ENOG4105CHR reductase FORC087_3505 ENOG4105EWU Squalene--hopene cyclase FORC087_3507 ENOG4105FR1 rard protein FORC087_3508 ENOG410696E Membrane FORC087_3511 ENOG4105D1F ATP-binding protein FORC087_3513 ENOG4108ZAF Molybdopterin FORC087_3514 ENOG4105CVM Molybdenum cofactor synthesis domain protein FORC087_3515 ENOG4105D06 uba thif-type nad fad binding protein FORC087_3516 ENOG4105TMB Formate nitrite transporter FORC087_3518 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FORC087_3519 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FORC087_3521 ENOG4108JB9 formate dehydrogenase FORC087_3522 ENOG4105E1K spore germination protein FORC087_3525 ENOG4105CUB amino acid FORC087_3537 ENOG4108KGH TRANSCRIPTIONal FORC087_3539 ENOG4105EMN RNA polymerase sigma factor FORC087_3541 ENOG4105CIG ABC transporter FORC087_3545 ENOG4105D9R oxidoreductase FORC087_3547 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FORC087_3548 ENOG4105K4P CoA-binding domain protein FORC087_3549 ENOG4105C0H protease FORC087_3550 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC087_3552 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FORC087_3553 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FORC087_3554 ENOG4105W8X HesB YadR YfhF-family protein FORC087_3560 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FORC087_3561 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC087_3563 ENOG4105BZ1 (ABC) transporter FORC087_3564 ENOG4108I0Z Aconitate hydratase FORC087_357 ENOG4108IQI permease FORC087_3570 ENOG4105E5W Transporter FORC087_3572 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FORC087_3576 ENOG4107F3J Amp-dependent synthetase and ligase FORC087_3577 ENOG4107ZYJ bioY protein FORC087_3578 ENOG4105CEY Amp-dependent synthetase and ligase FORC087_3579 ENOG4108IMY Transcriptional regulator FORC087_358 ENOG4108J5H Homocysteine s-methyltransferase FORC087_3584 ENOG4105D9G High-affinity FORC087_3585 ENOG4105IW1 AmiS UreI transporter FORC087_3588 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) FORC087_3596 ENOG4107AYK membrAne FORC087_3598 ENOG4105BZU Histidine kinase FORC087_3599 ENOG4105FBA Phospholipase Carboxylesterase FORC087_360 ENOG4105D7V transposase FORC087_3600 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FORC087_3602 ENOG4105CBC glutamate synthase FORC087_3603 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FORC087_3604 ENOG4108VJ1 Transcriptional regulator (CarD family FORC087_3605 ENOG4108903 Formimidoylglutamase FORC087_3607 ENOG4105CGP Urocanate hydratase FORC087_3610 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) FORC087_3611 ENOG4108Z0Z intracellular protease Pfpi family FORC087_3616 ENOG4107QIV Cytochrome c biogenesis protein FORC087_3620 ENOG4105CH2 amidohydrolase FORC087_3622 ENOG4105CJ1 ABC, transporter FORC087_3625 ENOG4107RSM transcriptional regulator FORC087_3626 ENOG4105VAW lrga family FORC087_3627 ENOG41067MG lrgb family FORC087_3635 ENOG4105BZ1 (ABC) transporter FORC087_3636 ENOG4105BZ1 (ABC) transporter FORC087_364 ENOG4105G9B Transcriptional regulator FORC087_3644 ENOG4108HW3 (ABC) transporter FORC087_3645 ENOG4105CGH 5'-nucleotidase FORC087_3647 ENOG4108SVB resolvase FORC087_3651 ENOG4105K7K Transcriptional regulator FORC087_3653 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FORC087_3654 ENOG4105E4C Lytic transglycosylase catalytic FORC087_3656 ENOG41065S2 pneumococcal vaccine antigen FORC087_366 ENOG4105CE7 Amidase, hydantoinase carbamoylase family FORC087_3664 ENOG4105C5F glutamine synthetase FORC087_3665 ENOG4105KV4 Transcriptional regulator FORC087_3666 ENOG4105CXI aluminum resistance protein FORC087_3667 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FORC087_3668 ENOG4105EN6 Membrane FORC087_3670 ENOG4106F1P AAA ATPase, central domain protein FORC087_3678 ENOG41069ER domain protein FORC087_3679 ENOG4105DM4 PTS System FORC087_3680 ENOG4105DE4 1-phosphofructokinase FORC087_3681 ENOG4105E98 transcriptional regulator DeoR family FORC087_3682 ENOG4107QW4 alcohol dehydrogenase FORC087_3683 ENOG4108SJC Membrane FORC087_3686 ENOG4105C85 amino acid FORC087_3689 ENOG4105TMB Formate nitrite transporter FORC087_3690 ENOG4105K70 DNA-binding protein FORC087_3692 ENOG4105C59 p-type ATPase FORC087_3693 ENOG410681U heavy metal transport detoxification protein FORC087_3694 ENOG4105VPX protein, conserved in bacteria FORC087_3696 ENOG4105NIV Esterase FORC087_3697 ENOG4105E0A ABC, transporter FORC087_3703 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FORC087_3704 ENOG4105D03 DNA-3-methyladenine glycosylase II FORC087_3705 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FORC087_3709 ENOG4105BZU Histidine kinase FORC087_3713 ENOG4105C5E polysaccharide biosynthesis protein FORC087_3717 ENOG41067MG lrgb family FORC087_372 ENOG4105DUX Transporter FORC087_3722 ENOG4108S3Y transcriptional regulator FORC087_3723 ENOG4105CS2 ec 3.2.1.21 FORC087_3724 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C FORC087_3727 ENOG4105F0V Cell wall hydrolase FORC087_3729 ENOG4105E0M Sulfatase FORC087_3730 ENOG410890F Dynamin family FORC087_3738 ENOG4105DQU oxidoreductase, subunit beta FORC087_3739 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FORC087_374 ENOG4105F6J Alpha beta hydrolase fold FORC087_3740 ENOG4108IGT Dipeptidase FORC087_3741 ENOG4105MCT stage V sporulation protein S FORC087_3742 ENOG4105D48 metallophosphoesterase FORC087_3748 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FORC087_3751 ENOG4105XZV Protein of unknown function (DUF3243) FORC087_3752 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FORC087_3756 ENOG4105UIB (ABC) transporter FORC087_3757 ENOG4108JQ9 ABC transporter FORC087_3758 ENOG4105DIH basic membrane FORC087_3759 ENOG4105FDP GntR family transcriptional regulator FORC087_3760 ENOG4105CNU cell division protein FtsK FORC087_3762 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FORC087_3764 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FORC087_3766 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FORC087_3767 ENOG4108S0H Dipicolinic acid synthetase, b subunit FORC087_377 ENOG4107Y9E nuclease FORC087_3770 ENOG4108IBT Inherit from COG: transposase FORC087_3775 ENOG4105XSJ toxin secretion phage lysis holin FORC087_381 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) FORC087_3812 ENOG4105CDU Replicative dna helicase FORC087_3820 ENOG4108IMY Transcriptional regulator FORC087_3826 ENOG4108S0H Dipicolinic acid synthetase, b subunit FORC087_3827 ENOG4105E35 Dipicolinate synthase subunit A FORC087_3829 ENOG4105C1V Peptidase, M16 FORC087_383 ENOG4105EMU Dehydrogenase FORC087_3833 ENOG4105DTN riboflavin biosynthesis protein ribF FORC087_3836 ENOG4105W7A Protein of unknown function (DUF503) FORC087_3838 ENOG4105VHM ribosomal protein FORC087_3839 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FORC087_3840 ENOG4105CHV Transcription elongation factor NusA FORC087_3842 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FORC087_3844 ENOG4105DZP Membrane-associated zinc metalloprotease FORC087_3845 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FORC087_3846 ENOG4105KNE Phosphatidate cytidylyltransferase FORC087_3847 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FORC087_3849 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FORC087_385 ENOG4108IG5 Transcriptional regulator FORC087_3855 ENOG4108HE4 integrase family FORC087_3857 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FORC087_3858 ENOG4105C79 DNA protecting protein DprA FORC087_3859 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FORC087_3862 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FORC087_3867 ENOG4105VB6 UPF0109 protein FORC087_3871 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FORC087_3872 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FORC087_3875 ENOG4105CHR reductase FORC087_3876 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FORC087_3879 ENOG4105CB5 ATP-dependent DNA helicase recG FORC087_3880 ENOG4105DP4 dak2 domain fusion protein ylov FORC087_3881 ENOG4108ZAA Alkaline-shock protein FORC087_3884 ENOG4105FJ0 thiamine FORC087_3885 ENOG4105DJV ribulose-phosphate 3-epimerase FORC087_3886 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FORC087_3887 ENOG4105D9P serine threonine protein kinase FORC087_3888 ENOG4108ZF3 Phosphatase FORC087_3890 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FORC087_3893 ENOG4105C25 Primosomal protein n' FORC087_3894 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FORC087_3898 ENOG4105DSJ YicC domain protein FORC087_3900 ENOG4105F23 Fibronectin-binding protein FORC087_3902 ENOG4105DC7 peptidase M24 FORC087_3909 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) FORC087_391 ENOG4108IAJ Nad-dependent epimerase dehydratase FORC087_3910 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FORC087_3912 ENOG4105CD3 dihydroorotase FORC087_3916 ENOG4105C34 Pseudouridine synthase FORC087_3919 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FORC087_392 ENOG4107SBE Glycosyl transferase (Group 1 FORC087_3921 ENOG4105DBK s4 domain protein FORC087_3922 ENOG41067XK integral membrane protein FORC087_3924 ENOG4105DFA alanine racemase domain protein FORC087_3925 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FORC087_3926 ENOG4105WR5 sporulation protein, YlmC YmxH family FORC087_3928 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC087_3930 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FORC087_3931 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FORC087_3934 ENOG4105D4A Cell wall formation (By similarity) FORC087_3935 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FORC087_3936 ENOG4105CNI cell division protein FtsW FORC087_3939 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FORC087_3940 ENOG4105CJN penicillin-binding protein FORC087_3941 ENOG4105CJN penicillin-binding protein FORC087_3944 ENOG41074B2 UPF0747 protein FORC087_3949 ENOG4105KNH Nucleic acid-binding protein FORC087_3951 ENOG41063PX domain protein FORC087_3952 ENOG4105D78 K07001 NTE family protein FORC087_3954 ENOG4105H20 Sporulation integral membrane protein YlbJ FORC087_3955 ENOG4106H78 methyltransferase FORC087_3959 ENOG4107TB6 phosphoglycerate mutase FORC087_396 ENOG4107SBE Glycosyl transferase (Group 1 FORC087_3962 ENOG4106UY4 Inherit from COG: Scp-like extracellular FORC087_397 ENOG4108KS4 Spore coat protein FORC087_3972 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FORC087_3973 ENOG4105CNI cell division protein FtsW FORC087_3976 ENOG4108IAB Phoh family FORC087_3980 ENOG4105QA2 FORC087_3981 ENOG4105CI3 gtp-binding protein typa FORC087_3983 ENOG4105ECY inositol monophosphatase FORC087_3988 ENOG4105CXN decarboxylase FORC087_3998 ENOG4105CPP Dehydrogenase, E1 component FORC087_4001 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FORC087_4002 ENOG4108X4Q Hydrolase FORC087_4004 ENOG4105CN5 Metallo-Beta-Lactamase FORC087_4005 ENOG4107ZYR domain protein FORC087_4012 ENOG4108XRC Protein of unknown function (DUF458) FORC087_4014 ENOG4107IN1 Protein of unknown function (DUF1797) FORC087_4018 ENOG4105EPM Diguanylate phosphodiesterase FORC087_4019 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FORC087_4022 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FORC087_4024 ENOG4105UIN FORC087_4031 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FORC087_4035 ENOG4108HGU Histidine kinase FORC087_4038 ENOG4105CHM Aminotransferase FORC087_4039 ENOG4105FKQ transcriptional regulator FORC087_4040 ENOG4105EG2 ABC transporter, permease FORC087_4042 ENOG4107FKK extracellular solute-binding protein family 1 FORC087_4044 ENOG4105CG3 alpha amylase, catalytic region FORC087_405 ENOG4105W1N transcriptional regulator FORC087_4054 ENOG4105CHU acetyl-coa acetyltransferase FORC087_4060 ENOG4105K7K Transcriptional regulator FORC087_4061 ENOG4105DTD Dehydrogenase FORC087_4065 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FORC087_4070 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FORC087_4073 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FORC087_4075 ENOG4105BZU Histidine kinase FORC087_4079 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FORC087_4082 ENOG4105CID antiterminator FORC087_4084 ENOG4105FDP GntR family transcriptional regulator FORC087_4086 ENOG4105CE4 GlcNAc 6-P deacetylase FORC087_4093 ENOG4107ZE5 PPIases accelerate the folding of proteins FORC087_4094 ENOG4105PTM secreted protein FORC087_4095 ENOG4105J7I hydrolase FORC087_4097 ENOG4105G6R Stage v sporulation protein ae FORC087_4099 ENOG4105CZ3 stage V sporulation protein ad FORC087_4100 ENOG41090VF Stage v sporulation protein ac FORC087_4104 ENOG4105C8J )-transporter FORC087_4105 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC087_4107 ENOG41082AN stage II sporulation protein FORC087_4108 ENOG4105DZ1 carboxypeptidase FORC087_4109 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FORC087_411 ENOG4105ZUU Transcriptional regulator FORC087_4110 ENOG4105DVE abc transporter atp-binding protein FORC087_4117 ENOG4105D7N magnesium and cobalt transport protein CorA FORC087_4122 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FORC087_4124 ENOG4105I3K Ferric uptake regulator, Fur family FORC087_4125 ENOG4105MZ9 stage II sporulation protein m FORC087_4130 ENOG4105CPC Aldo Keto reductase FORC087_4132 ENOG4105RHY Pfam:UPF0157 FORC087_4136 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FORC087_4138 ENOG4105ETE Transcriptional regulator (LacI family FORC087_4139 ENOG4108YM7 Gcn5-related n-acetyltransferase FORC087_4143 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FORC087_4144 ENOG4108R6K riboflavin synthase, subunit alpha FORC087_4149 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FORC087_415 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC087_4150 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FORC087_4153 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FORC087_4155 ENOG4105DFD Na H antiporter FORC087_4156 ENOG4105CGH 5'-nucleotidase FORC087_416 ENOG4105D7V transposase FORC087_4161 ENOG4105DBV ornithine carbamoyltransferase FORC087_4164 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FORC087_4167 ENOG4108IXY short-chain dehydrogenase reductase FORC087_4168 ENOG41069FQ Metallo-beta-lactamase superfamily FORC087_4169 ENOG4105II7 pyrroline-5-carboxylate reductase FORC087_4170 ENOG4105EJQ L-serine dehydratase FORC087_4173 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FORC087_4176 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FORC087_4179 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FORC087_4180 ENOG4105D9U N-acetyltransferase FORC087_4183 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FORC087_4184 ENOG4108QEG Membrane FORC087_4185 ENOG4105CDA abc transporter atp-binding protein FORC087_4186 ENOG4105E5Q amino acid AbC transporter FORC087_4187 ENOG4108HW3 (ABC) transporter FORC087_4189 ENOG4105G7B Protein of unknown function (DUF2992) FORC087_4191 ENOG4108QY0 Membrane FORC087_4193 ENOG4105C7S Dehydrogenase FORC087_4194 ENOG4105CPP Dehydrogenase, E1 component FORC087_4198 ENOG4107RDP Dehydrogenase FORC087_4200 ENOG4108JUB Transcriptional regulator FORC087_4202 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FORC087_4205 ENOG4107QQR Sporulation FORC087_4206 ENOG4105S1Z Stage IV sporulation protein B FORC087_4207 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FORC087_4208 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FORC087_4209 ENOG4105DX0 Hemolysin A FORC087_4211 ENOG4105CTB Polyprenyl synthetase FORC087_4214 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FORC087_4216 ENOG4108ZSR alkaline shock protein FORC087_4217 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FORC087_4221 ENOG410644B Stage III sporulation protein af FORC087_4223 ENOG4105KQ4 Stage iii sporulation protein ad FORC087_4224 ENOG4108CQH stage III sporulation protein AC FORC087_4225 ENOG4105KR5 Stage iii sporulation protein FORC087_4226 ENOG4105CD2 stage iii sporulation protein aa FORC087_4231 ENOG4105DC7 peptidase M24 FORC087_4232 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FORC087_4234 ENOG4105CBJ Metal-dependent enzyme FORC087_4235 ENOG4107YBY Hydrolase FORC087_4242 ENOG41082GG biotin lipoate A B protein ligase FORC087_4243 ENOG4105WZW rhodanese family FORC087_4248 ENOG41080TC multidrug resistance protein FORC087_4255 ENOG4105CJ1 ABC, transporter FORC087_4256 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FORC087_426 ENOG4105C19 ABC transporter FORC087_4262 ENOG4105C0D helicase FORC087_4287 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FORC087_4288 ENOG4105C3R Methionine synthase FORC087_4291 ENOG4105C28 cystathionine FORC087_4292 ENOG4105C28 cystathionine FORC087_4296 ENOG4105C5X domain protein FORC087_4298 ENOG4105DKQ ROK family FORC087_4300 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FORC087_4303 ENOG4108UTW Plays a role in the regulation of phosphate uptake FORC087_4304 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FORC087_4305 ENOG4105C8U phosphate abc transporter FORC087_4306 ENOG4105C8U phosphate abc transporter FORC087_4307 ENOG4105EXS phosphate abc transporter FORC087_4308 ENOG4107RF6 penicillin-binding protein FORC087_4310 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FORC087_4315 ENOG4105N80 Ferric uptake regulator, Fur family FORC087_4317 ENOG4105FDK ABC transporter FORC087_4318 ENOG4108JYZ YitT family FORC087_4319 ENOG41069ZM Protein of unknown function (DUF2624) FORC087_432 ENOG4107SDT Homocitrate synthase FORC087_4325 ENOG4105EGD dinuclear metal center protein, YbgI family FORC087_4328 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC087_4329 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FORC087_4336 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FORC087_4337 ENOG4105KG3 cytidine deaminase FORC087_4338 ENOG4107YR5 Diacylglycerol kinase FORC087_4340 ENOG4105CTJ Metal Dependent Phosphohydrolase FORC087_4341 ENOG4105C9A Phoh family FORC087_4343 ENOG41068P3 sporulation protein YqfC FORC087_4344 ENOG4105KTH gatB Yqey FORC087_4346 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FORC087_4347 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FORC087_4353 ENOG4105CSA Coproporphyrinogen iii oxidase FORC087_4354 ENOG4105KVH Transcriptional regulator FORC087_4359 ENOG4105TQK DNA polymerase iii, delta' subunit FORC087_436 ENOG4105D06 uba thif-type nad fad binding protein FORC087_4362 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FORC087_4363 ENOG4108UK2 deaminase FORC087_4364 ENOG4105KQC Competence protein FORC087_4366 ENOG4105DXX methyltransferase FORC087_4368 ENOG4108WF2 Metal Dependent Phosphohydrolase FORC087_4370 ENOG410812S Rna-binding protein FORC087_4372 ENOG4105CQW ribosome biogenesis GTPase YqeH FORC087_4373 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FORC087_4376 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC087_4380 ENOG4108TVJ Nitroreductase FORC087_4383 ENOG4105G6Z alkaline phosphatase FORC087_4384 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FORC087_4385 ENOG4108MUZ hydrolase FORC087_4394 ENOG4105MIR Phenylalanine 4-monooxygenase FORC087_4396 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FORC087_4405 ENOG4105S6R Iron-hydroxamate transporter permease subunit FORC087_4406 ENOG4108V5C ABC transporter FORC087_4408 ENOG4108EKI Dehydrogenase FORC087_4409 ENOG4105C28 cystathionine FORC087_4415 ENOG4107XRG penicillin-binding protein FORC087_4417 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FORC087_4419 ENOG4105CFP Peptidase U32 FORC087_4420 ENOG4105XYU peptidase (U32 family) FORC087_4421 ENOG4108VQJ O-methyltransferase FORC087_4422 ENOG4105HHA aminodeoxychorismate lyase FORC087_4426 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FORC087_4428 ENOG4105C02 permease FORC087_443 ENOG4105BZU Histidine kinase FORC087_4431 ENOG41060CR FORC087_4432 ENOG4105C7H Helicase, RecD TraA family FORC087_4434 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FORC087_4435 ENOG4105C3J Cysteine desulfurase FORC087_4437 ENOG4105D1H recombination factor protein RarA FORC087_4438 ENOG4108VCI transcription factor, rsfa family FORC087_444 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC087_4440 ENOG4105CUZ uba thif-type nad fad binding protein FORC087_4442 ENOG4105CUT histidyl-tRNA synthetase FORC087_4444 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FORC087_4445 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FORC087_4447 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FORC087_4448 ENOG41076HS cation diffusion facilitator family transporter FORC087_4449 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FORC087_4451 ENOG4105CKP Polysaccharide Biosynthesis Protein FORC087_4452 ENOG4108QG2 Membrane FORC087_4454 ENOG4105VIE preprotein translocase, subunit YajC FORC087_4457 ENOG41061AI Protein of unknown function (DUF2905) FORC087_446 ENOG4105YWU small acid-soluble spore protein FORC087_4460 ENOG4108HUF Transporter FORC087_4462 ENOG4108IPJ Membrane FORC087_4463 ENOG41082BM Transcriptional regulator, arsr family FORC087_4468 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FORC087_4469 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FORC087_4470 ENOG4108IYU L-aspartate oxidase FORC087_4473 ENOG4108RPX mosc domain containing protein FORC087_4475 ENOG4105CQC Prephenate dehydratase FORC087_4478 ENOG4105C19 ABC transporter FORC087_4479 ENOG4105EWM Histidine kinase FORC087_4481 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FORC087_4484 ENOG4105X36 (ribosomal) protein FORC087_4486 ENOG4105C03 ribonuclease FORC087_4489 ENOG4107QMS site-determining protein FORC087_4492 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FORC087_4493 ENOG4105DFF Rod shape-determining protein mreb FORC087_4497 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FORC087_4498 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FORC087_4500 ENOG41068KH stage VI sporulation protein D FORC087_4502 ENOG4105D52 delta-aminolevulinic acid dehydratase FORC087_4508 ENOG4105K56 Transcriptional regulator FORC087_4512 ENOG4108IUQ atp-dependent protease FORC087_4519 ENOG4108QCI YvbH-like oligomerisation region FORC087_4530 ENOG4105M59 Phosphodiesterase, mj0936 family FORC087_4531 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FORC087_4533 ENOG4108XJQ germination protein FORC087_4537 ENOG4105PFC Transcriptional regulator FORC087_454 ENOG4105EQ0 Major Facilitator superfamily FORC087_4540 ENOG4105DZC cytosine deaminase FORC087_4541 ENOG41067S9 phage shock protein C, PspC FORC087_4542 ENOG4108JCI Transcriptional regulator FORC087_4544 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FORC087_4545 ENOG4108Z40 Transcriptional regulator FORC087_4546 ENOG4105RHA ABC transporter, permease FORC087_4547 ENOG4108IUX (ABC) transporter FORC087_4548 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FORC087_4549 ENOG4105ER2 Ompa motb domain protein FORC087_455 ENOG4108JGH Tetr family transcriptional regulator FORC087_4550 ENOG4105E14 MotA TolQ exbB proton channel FORC087_4551 ENOG4108VXD carboxy-peptidase FORC087_4553 ENOG4105E33 succinate dehydrogenase FORC087_4555 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FORC087_4557 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FORC087_4558 ENOG4105K63 Thioredoxin FORC087_4559 ENOG4105C10 Electron transfer flavoprotein FORC087_4560 ENOG4105BZJ Electron transfer flavoprotein FORC087_4561 ENOG41060WC Enoyl-CoA hydratase FORC087_4562 ENOG4107Z3H Transcriptional regulator, TetR family FORC087_4563 ENOG4105CEY Amp-dependent synthetase and ligase FORC087_4565 ENOG4105J76 Periplasmic binding protein FORC087_457 ENOG4105BZ4 penicillin-binding protein FORC087_4575 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC087_4578 ENOG4105DR4 Methyltransferase FORC087_458 ENOG41086D8 Transcriptional regulator FORC087_4580 ENOG4105KFN sortase, SrtB family FORC087_4581 ENOG4105E0A ABC, transporter FORC087_4584 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FORC087_4586 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FORC087_4588 ENOG4105FE9 pseudouridine synthase FORC087_4591 ENOG4105DCG PHP domain protein FORC087_4594 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FORC087_4598 ENOG4105C5S asparaginyl-tRNA synthetase FORC087_4599 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FORC087_4601 ENOG4108RWN rrna methyltransferase FORC087_4607 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC087_4608 ENOG4105CW7 secretion protein, HlyD family FORC087_4609 ENOG4108JGH Tetr family transcriptional regulator FORC087_4610 ENOG4105CN9 Peptidase m42 family protein FORC087_4614 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FORC087_4615 ENOG4105C22 threonyL-tRNA synthetase FORC087_4616 ENOG4108TDW sporulation protein YtxC FORC087_4621 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FORC087_4623 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FORC087_4624 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FORC087_4626 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FORC087_4627 ENOG4105C2M dna polymerase I FORC087_4628 ENOG4105BZU Histidine kinase FORC087_4629 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC087_4634 ENOG4108HMX isocitrate dehydrogenase (NADP) FORC087_4635 ENOG4105BZN citrate synthase FORC087_4637 ENOG4108REF Sporulation integral membrane protein ytvi FORC087_4638 ENOG4105FS0 cytoplasmic membrane protein FORC087_4643 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FORC087_4644 ENOG4105C6K Malic enzyme FORC087_4645 ENOG4105C0B DNA polymerase III (alpha subunit) FORC087_4646 ENOG4105VV2 FORC087_4648 ENOG4105SFS phosphoesterase RecJ domain protein FORC087_4653 ENOG4105E8R UPF0173 metal-dependent hydrolase FORC087_4654 ENOG4105DC7 peptidase M24 FORC087_4661 ENOG41082W1 Cupin 2, conserved barrel domain protein FORC087_4665 ENOG4107YZX Universal stress protein FORC087_4675 ENOG4108JYZ YitT family FORC087_4679 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FORC087_468 ENOG4107RF6 penicillin-binding protein FORC087_4681 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FORC087_4682 ENOG4105KBJ sporulation protein ytfj FORC087_4685 ENOG4105EFZ amidohydrolase FORC087_4687 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FORC087_4692 ENOG4105RQF LysR family Transcriptional regulator FORC087_4694 ENOG4105U5Y Transcriptional regulator FORC087_4696 ENOG4105C28 cystathionine FORC087_470 ENOG4105EMN RNA polymerase sigma factor FORC087_4706 ENOG4105EMN RNA polymerase sigma factor FORC087_4708 ENOG4108UW5 maltose o-acetyltransferase FORC087_471 ENOG4108BUD transposase FORC087_4710 ENOG4105F1V Acetoin utilization protein FORC087_4711 ENOG4105W87 Cbs domain FORC087_4712 ENOG4105DGU Histone deacetylase FORC087_4715 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC087_4716 ENOG4105BZU Histidine kinase FORC087_4717 ENOG4107SNB ankyrin repeat protein YahD FORC087_4722 ENOG4105DY9 regulatoR FORC087_4723 ENOG4105EP9 oxidoreductase FORC087_4729 ENOG4105ETE Transcriptional regulator (LacI family FORC087_473 ENOG4105C19 ABC transporter FORC087_4730 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FORC087_4734 ENOG4105C88 aminopeptidase FORC087_4741 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FORC087_4743 ENOG4108VDD TRNA binding domain protein FORC087_4749 ENOG4105C8F Beta-lactamase domain protein FORC087_4752 ENOG4108V15 phosphotransferase enzyme family FORC087_4753 ENOG4108IUM Glycogen debranching enzyme FORC087_4755 ENOG4107QSE Dipeptidase FORC087_4756 ENOG4105YW5 deoR family transcriptional regulator FORC087_4759 ENOG4105CBX hi0933 family FORC087_4767 ENOG4108VJ1 Transcriptional regulator (CarD family FORC087_4768 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FORC087_4769 ENOG4105CSC Glucose uptake protein FORC087_4772 ENOG4108ZAF Molybdopterin FORC087_4773 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FORC087_4774 ENOG4105CVM Molybdenum cofactor synthesis domain protein FORC087_4776 ENOG4105D06 uba thif-type nad fad binding protein FORC087_4777 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FORC087_4781 ENOG41085GJ domain protein FORC087_4783 ENOG4105DWV Homoserine O-trans-acetylase FORC087_4785 ENOG4108B31 Spore germination protein FORC087_479 ENOG4105C19 ABC transporter FORC087_4791 ENOG4105C8T Leucyl-tRNA synthetase FORC087_4792 ENOG410605W Major Facilitator FORC087_4793 ENOG4107S91 Sodium hydrogen exchanger FORC087_4794 ENOG4105NCW Trka-c domain protein FORC087_4797 ENOG4105C19 ABC transporter FORC087_4801 ENOG4105N5T Radical SAM Protein FORC087_4803 ENOG4105DA5 (ABC) transporter FORC087_4808 ENOG4105E8V Alpha Beta Hydrolase Fold protein FORC087_4809 ENOG4108Z0R Transferase FORC087_4810 ENOG4105YVM Phosphoesterase, PA-phosphatase related FORC087_4811 ENOG4105BZF Glycosyl transferase (Group 1 FORC087_4813 ENOG4105EPU Molybdenum cofactor synthesis domain protein FORC087_4816 ENOG4108MK9 spermidine N(1)-acetyltransferase FORC087_4825 ENOG4105BZU Histidine kinase FORC087_4826 ENOG4105BZU Histidine kinase FORC087_4827 ENOG4107S9D Alpha beta hydrolase FORC087_4828 ENOG4107T7U Sulfatase FORC087_4833 ENOG4105D2X ABC transporter substrate-binding protein FORC087_4835 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FORC087_4846 ENOG4108V2W Carbonate dehydratase FORC087_4848 ENOG4105C4M (Ubiquinol oxidase) subunit I FORC087_4849 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FORC087_4858 ENOG41087YS Phage shock protein A FORC087_4864 ENOG4105BZU Histidine kinase FORC087_4865 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC087_4870 ENOG4108UGV hypoxanthine phosphoribosyltransferase FORC087_4871 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FORC087_4877 ENOG4107ZTW SNARE associated Golgi FORC087_488 ENOG4105C19 ABC transporter FORC087_4880 ENOG4105C19 ABC transporter FORC087_4881 ENOG41086D8 Transcriptional regulator FORC087_4884 ENOG41082BM Transcriptional regulator, arsr family FORC087_4894 ENOG4105C6Z Gluconate FORC087_4895 ENOG4105FDP GntR family transcriptional regulator FORC087_4899 ENOG41069H0 dihydroorotase EC 3.5.2.3 FORC087_4903 ENOG4105DTQ mandelate racemase muconate lactonizing FORC087_4904 ENOG4105D7V transposase FORC087_4910 ENOG4108IPT Naphthoate synthase FORC087_4911 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FORC087_4913 ENOG4105E4F Isochorismate synthase FORC087_4915 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FORC087_4917 ENOG4105VEQ Cold shock protein FORC087_492 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC087_4925 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FORC087_4929 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FORC087_4930 ENOG4105KT7 mgtC SapB transporter FORC087_4932 ENOG4107PBV potassium channel FORC087_4934 ENOG4105WG9 Conserved Protein FORC087_4936 ENOG4105CHM Aminotransferase FORC087_4937 ENOG4108ZB6 transcriptional regulator AsnC family FORC087_4938 ENOG4105C5I Dehydrogenase FORC087_4939 ENOG4108MUZ hydrolase FORC087_4941 ENOG4105C87 Aminotransferase class I and II FORC087_4944 ENOG4105Y38 Kinase-associated protein B FORC087_4946 ENOG4107R3E Citrate transporter FORC087_4949 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FORC087_4950 ENOG4105KA0 thioesterase Superfamily protein FORC087_4953 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FORC087_4957 ENOG41069ER domain protein FORC087_4960 ENOG4105CEP NADH dehydrogenase FORC087_4966 ENOG4105EWC Purine nucleoside phosphorylase FORC087_4970 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FORC087_4975 ENOG4108JJA ABC, transporter FORC087_4976 ENOG4105C4B ABC transporter, permease FORC087_4977 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FORC087_4984 ENOG41083MR nifu domain-containing protein FORC087_4987 ENOG4108W5N phosphatidylglycerophosphatase a FORC087_4991 ENOG4105DAX Pfam:DUF2983 FORC087_4994 ENOG4105DYS nad(p)h dehydrogenase (quinone) FORC087_4995 ENOG4105D4U had-superfamily hydrolase, subfamily iia FORC087_4998 ENOG4105CBT Fructose-1,6-bisphosphatase FORC087_5000 ENOG4105C34 Pseudouridine synthase FORC087_5001 ENOG4105MMD transcriptional regulator FORC087_5002 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FORC087_5003 ENOG4107TXC Transcriptional regulator FORC087_5004 ENOG41090T1 Membrane FORC087_5009 ENOG4105FAA peptidase M23 FORC087_5010 ENOG4108YTE sporulation protein YunB FORC087_5011 ENOG4105KZD Domain of unknown function (DUF1805) FORC087_5012 ENOG4107R8B 5'-nucleotidase FORC087_5015 ENOG4105DIW FeS assembly protein SUFB FORC087_5016 ENOG4108UNV SUF system FeS assembly protein, NifU family FORC087_5017 ENOG4105C9B Cysteine desulfurase FORC087_5018 ENOG4105JRK feS assembly protein SufD FORC087_5019 ENOG4105C3K feS assembly ATPase SufC FORC087_5020 ENOG4105D01 (LipO)protein FORC087_5021 ENOG4105D01 (LipO)protein FORC087_5022 ENOG4108UMI ABC transporter, permease FORC087_5023 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FORC087_5030 ENOG41080E8 Transcriptional regulator, Spx MgsR family FORC087_5034 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FORC087_5040 ENOG4108W8B Beta-lactamase domain protein FORC087_5041 ENOG4105C1G acyl-Coa dehydrogenase FORC087_5043 ENOG4105CHU acetyl-coa acetyltransferase FORC087_5046 ENOG4105DZ1 carboxypeptidase FORC087_505 ENOG4107WD8 ABC transporter, permease FORC087_5050 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FORC087_5053 ENOG4105F27 Major Facilitator FORC087_5054 ENOG4107R7I amino acid FORC087_5056 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FORC087_5058 ENOG4107AYK membrAne FORC087_5065 ENOG4107ZTW SNARE associated Golgi FORC087_5067 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FORC087_5068 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC087_5069 ENOG4105BZU Histidine kinase FORC087_507 ENOG4105C0H protease FORC087_5072 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FORC087_5075 ENOG4105C8Q Methyl-accepting chemotaxis FORC087_5076 ENOG4105VG1 fes assembly suf system protein FORC087_5077 ENOG4105D4Y metalloprotease FORC087_5081 ENOG4107T5V SNARE associated Golgi FORC087_5082 ENOG4107S91 Sodium hydrogen exchanger FORC087_5083 ENOG4105NCW Trka-c domain protein FORC087_5086 ENOG4108RMU ferritin dps family protein FORC087_5089 ENOG4108URH decarboxylase FORC087_509 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC087_5091 ENOG41090A1 ferritin FORC087_5092 ENOG4105DHF Membrane FORC087_5093 ENOG4105D9N nucleoside FORC087_5094 ENOG4105D9N nucleoside FORC087_5098 ENOG4108RYK Nad-dependent epimerase dehydratase FORC087_510 ENOG4105BZU Histidine kinase FORC087_5101 ENOG4105CV8 reductase FORC087_5102 ENOG4105F27 Major Facilitator FORC087_5103 ENOG4105KVH Transcriptional regulator FORC087_5106 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FORC087_5107 ENOG4105D4A Cell wall formation (By similarity) FORC087_5109 ENOG4105C8Q Methyl-accepting chemotaxis FORC087_5111 ENOG4105WMR Protein CrcB homolog FORC087_5112 ENOG4105WMR Protein CrcB homolog FORC087_5116 ENOG4105C5H ABC transporter FORC087_5117 ENOG4108MK9 spermidine N(1)-acetyltransferase FORC087_5118 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FORC087_5122 ENOG4108V2W Carbonate dehydratase FORC087_5123 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) FORC087_5127 ENOG4108IPW abc transporter atp-binding protein FORC087_5128 ENOG4105CM4 permease protein FORC087_513 ENOG4105D7V transposase FORC087_5131 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC087_5133 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FORC087_5135 ENOG4105XZU Preprotein translocase, subunit SecG FORC087_5136 ENOG41067MG lrgb family FORC087_514 ENOG4105EKQ RNA-directed DNA polymerase FORC087_5146 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC087_5149 ENOG41090VF Stage v sporulation protein ac FORC087_5150 ENOG4105CZ3 stage V sporulation protein ad FORC087_5153 ENOG4108QY0 Membrane FORC087_5154 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FORC087_5155 ENOG4105KRI phosphocarrier protein (HPr FORC087_5157 ENOG4105CHW UPF0052 protein FORC087_5158 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FORC087_5159 ENOG4108Z4K mutator MutT protein FORC087_5161 ENOG4105C3M thioredoxin reductase FORC087_5163 ENOG4108S4C acetyltransferase FORC087_5167 ENOG41086DT Membrane protein of unknown function FORC087_5169 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FORC087_5170 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FORC087_5173 ENOG4107TXC Transcriptional regulator FORC087_5177 ENOG4105DUM transcriptional regulator, lysR family FORC087_5179 ENOG4108WS4 fmn reductase FORC087_5182 ENOG4105BZ1 (ABC) transporter FORC087_5184 ENOG4105CN1 protease FORC087_5185 ENOG4105CRP Part of the ABC transporter FtsEX involved in FORC087_5186 ENOG4105CAK Cell division ATP-binding protein ftsE FORC087_5192 ENOG4108RDQ ABC transporter FORC087_5198 ENOG4105MS2 ribosomal subunit Interface protein FORC087_5200 ENOG4105VEQ Cold shock protein FORC087_5201 ENOG41081UC Inherit from COG: Competence protein FORC087_5204 ENOG4105KVH Transcriptional regulator FORC087_5207 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FORC087_5208 ENOG4108KGH TRANSCRIPTIONal FORC087_5209 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FORC087_5210 ENOG4105C6Y Udp-glucose 6-dehydrogenase FORC087_5211 ENOG4105ESV Glycosyl transferase, family 4 FORC087_5213 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FORC087_5217 ENOG4105F8D glycoside hydrolase family 4 FORC087_5218 ENOG4105VCP PTS System FORC087_5219 ENOG4105CK1 PTS System FORC087_522 ENOG4108IMY Transcriptional regulator FORC087_5221 ENOG4105VCP PTS System FORC087_5223 ENOG4105VZJ PTS System FORC087_5228 ENOG4105ECB domain protein FORC087_5229 ENOG4107RSM transcriptional regulator FORC087_523 ENOG4105BZC d-serine deaminase FORC087_5236 ENOG4105DAA L-lactate FORC087_5238 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FORC087_5240 ENOG4105E0M Sulfatase FORC087_5249 ENOG4107R8N Glycosyl transferase, family 2 FORC087_5251 ENOG4105C94 Transporter FORC087_5252 ENOG41069ER domain protein FORC087_5257 ENOG4105KBK Zinc finger, swim domain protein FORC087_5258 ENOG4105C0D helicase FORC087_5264 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC087_5266 ENOG4107RBB ABC transporter, permease FORC087_5267 ENOG4105C19 ABC transporter FORC087_5271 ENOG4105CXY transporter FORC087_5274 ENOG4105BZU Histidine kinase FORC087_5275 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC087_5276 ENOG4105CMR udp-glucose 4-epimerase FORC087_5278 ENOG4108KGH TRANSCRIPTIONal FORC087_5280 ENOG4107TAE Glycosyl transferase (Group 1 FORC087_5281 ENOG4105K64 Glycosyl transferase, family 2 FORC087_5287 ENOG4105D3Q Sugar transferase FORC087_5288 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FORC087_5290 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FORC087_5291 ENOG4107YJ4 chain length determinant protein FORC087_5292 ENOG4105HTX biosynthesis protein FORC087_5293 ENOG4107YJ4 chain length determinant protein FORC087_5296 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FORC087_5298 ENOG4105FRN stage II sporulation protein FORC087_5301 ENOG4108IUW ABC transporter FORC087_5305 ENOG4106778 Protein of unknown function (DUF1146) FORC087_5306 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FORC087_5307 ENOG4105C8S subunit m FORC087_5308 ENOG4105D65 subunit l FORC087_5313 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FORC087_5314 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FORC087_5316 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FORC087_5317 ENOG4105BZU Histidine kinase FORC087_5327 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FORC087_5328 ENOG41062M3 atp synthase FORC087_5332 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FORC087_5333 ENOG4108UIC UPF0340 protein FORC087_5334 ENOG4108YZG isomerase FORC087_5337 ENOG4108VGI doxx family FORC087_5338 ENOG4107XC4 flavin reductase domain protein, FMN-binding FORC087_5342 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FORC087_5344 ENOG4108ZXQ stage ii sporulation protein r FORC087_5345 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FORC087_5346 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FORC087_5347 ENOG4107104 thymidine kinase FORC087_5349 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FORC087_5350 ENOG4105CBT Fructose-1,6-bisphosphatase FORC087_5352 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FORC087_5356 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FORC087_5359 ENOG4105C1G acyl-Coa dehydrogenase FORC087_5360 ENOG4105C1G acyl-Coa dehydrogenase FORC087_5361 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FORC087_5363 ENOG4105DF6 Fe-S oxidoreductase FORC087_5366 ENOG4105BZU Histidine kinase FORC087_5369 ENOG4105D4Y metalloprotease FORC087_5371 ENOG4105BZU Histidine kinase FORC087_5372 ENOG4105KCT ABC transporter FORC087_5373 ENOG4108M15 ABC transporter FORC087_5374 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FORC087_5376 ENOG4105IIU Aminopeptidase FORC087_5380 ENOG4105EMN RNA polymerase sigma factor FORC087_5382 ENOG410684U Domain of unknown function (DUF1934) FORC087_5386 ENOG4105CYW agmatinase FORC087_5388 ENOG4105DXB Major Facilitator superfamily FORC087_5389 ENOG4107SWG transcriptional regulator MERR family FORC087_539 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FORC087_5391 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FORC087_5392 ENOG4105BZ4 penicillin-binding protein FORC087_5393 ENOG4108XFG YwhD family FORC087_5394 ENOG4108Z4T Peptidase M50 FORC087_5395 ENOG41069HH 4-oxalocrotonate tautomerase FORC087_5396 ENOG4105DCI Phosphohydrolase FORC087_5397 ENOG4108MES Periplasmic binding protein FORC087_5398 ENOG4105E0A ABC, transporter FORC087_5399 ENOG4105EHG Permease protein FORC087_5400 ENOG4105DQ5 transport system permease protein FORC087_5402 ENOG4108VCI transcription factor, rsfa family FORC087_5403 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) FORC087_5404 ENOG4108IJ2 phosphate acetyltransferase FORC087_5405 ENOG4107UEZ chlorite dismutase FORC087_5407 ENOG4108VKI Cell wall hydrolase FORC087_5411 ENOG4107SVH Potassium channel protein FORC087_5413 ENOG410667J hydrolase FORC087_5414 ENOG4105VCH membrane FORC087_5416 ENOG4108TU7 Inherit from COG: (ABC) transporter FORC087_5417 ENOG4105CJ1 ABC, transporter FORC087_5418 ENOG41090WU lipolytic protein G-D-S-L family FORC087_5421 ENOG4105D6E homoserine dehydrogenase FORC087_5426 ENOG4108Y4K DNA-binding transcriptional activator FORC087_5428 ENOG4105WH1 Two component transcriptional regulator luxr family FORC087_5429 ENOG4105BZU Histidine kinase FORC087_543 ENOG4105CNU cell division protein FtsK FORC087_5430 ENOG4105DWF phosphomethylpyrimidine kinase FORC087_5431 ENOG4105BZU Histidine kinase FORC087_5432 ENOG4105VCD cytoplasmic protein FORC087_5433 ENOG4105D22 carbon starvation protein FORC087_5434 ENOG4105DY9 regulatoR FORC087_5435 ENOG41079KZ Major Facilitator Superfamily FORC087_5438 ENOG4105CG5 Glycosyl transferase (Group 1 FORC087_5440 ENOG4105EN6 Membrane FORC087_5441 ENOG4106YBV Methyl-accepting chemotaxis FORC087_5443 ENOG4108S4H thioesterase Superfamily protein FORC087_5444 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) FORC087_5447 ENOG4105K64 Glycosyl transferase, family 2 FORC087_5449 ENOG4105EJV Membrane FORC087_5450 ENOG4105CKK Glycosyl transferase, family 2 FORC087_5451 ENOG4105C5H ABC transporter FORC087_5452 ENOG41067SE Tetr family transcriptional regulator FORC087_5454 ENOG4105E0X reductase FORC087_5455 ENOG4106F5Q Membrane FORC087_5458 ENOG4108NEV two component transcriptional regulator, LytTR family FORC087_5459 ENOG4108HRK Histidine kinase FORC087_5460 ENOG4107RGD Major Facilitator superfamily FORC087_5463 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FORC087_5465 ENOG4105IW1 AmiS UreI transporter FORC087_5466 ENOG4105CMR udp-glucose 4-epimerase FORC087_5467 ENOG4108UT2 hemolysin iii FORC087_5469 ENOG4105C1J atp-dependent rna helicase FORC087_5470 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) FORC087_5475 ENOG4105BZU Histidine kinase FORC087_5479 ENOG4105C0H protease FORC087_5480 ENOG4105Q2H domain protein FORC087_5483 ENOG4105BZU Histidine kinase FORC087_5484 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC087_5485 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FORC087_5486 ENOG4105CDU Replicative dna helicase FORC087_5488 ENOG4105BZR domain protein FORC087_5489 ENOG4108XMW Membrane FORC087_5491 ENOG4108UUM single-stranded DNA-binding protein FORC087_5493 ENOG4105C3G gtp-binding protein FORC087_5494 ENOG4105VDK protein, conserved in bacteria FORC087_5495 ENOG4105D8X mechanosensitive ion channel FORC087_5496 ENOG4108ZDA Sporulation protein YyaC FORC087_5497 ENOG4105FA0 parb-like partition protein FORC087_5498 ENOG4107QJE Chromosome Partitioning Protein FORC087_5501 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FORC087_5502 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FORC087_5504 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FORC087_557 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC087_593 ENOG4108Q5U germination protein, ger(x)c family FORC087_603 ENOG4105C19 ABC transporter FORC087_604 ENOG4107RBB ABC transporter, permease FORC087_610 ENOG4108IUW ABC transporter FORC087_615 ENOG4105G5W regulator Fur family FORC087_626 ENOG4105XSJ toxin secretion phage lysis holin FORC087_630 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FORC087_643 ENOG4107QJE Chromosome Partitioning Protein FORC087_672 ENOG4108IMY Transcriptional regulator FORC087_684 ENOG4106CVF DNA replication protein FORC087_691 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FORC087_697 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) FORC087_703 ENOG4108C33 Resolvase FORC087_t098 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation