locus-tag class description FORC60_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FORC60_0003 ENOG410848D S4 domain protein YaaA FORC60_0006 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FORC60_0008 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FORC60_0014 ENOG4105ZMH deoxynucleoside kinase FORC60_0016 ENOG4105GTG Isochorismatase FORC60_0017 ENOG4108Z6B deaminase FORC60_0018 ENOG4105C6E dna polymerase iii FORC60_0022 ENOG41067KS pro-sigma K processing FORC60_0024 ENOG4105CXN decarboxylase FORC60_0026 ENOG4105FA2 dna polymerase iii FORC60_0027 ENOG4105MA4 psp1 domain protein FORC60_0029 ENOG41060K3 Methyltransferase FORC60_0031 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FORC60_0032 ENOG4105KRN Transcriptional regulator, abrb family FORC60_0033 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FORC60_0035 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FORC60_0037 ENOG4105XFA sporulation peptidase YabG FORC60_0038 ENOG4105W42 Veg protein FORC60_0041 ENOG4105DFT pur operon repressor FORC60_0042 ENOG4105KME endoribonuclease L-psp FORC60_0045 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FORC60_0046 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FORC60_0048 ENOG4108JA2 transcriptioN-repair coupling factor FORC60_0049 ENOG4108M14 stage v sporulation protein t FORC60_0051 ENOG4108IY2 MazG family FORC60_0052 ENOG41082I2 s4 domain protein FORC60_0053 ENOG4105VYY sporulation protein yabp FORC60_0056 ENOG41060GV RNA binding s1 domain protein FORC60_0058 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FORC60_0059 ENOG4108UGV hypoxanthine phosphoribosyltransferase FORC60_0060 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FORC60_0063 ENOG4105C6T cysteine synthase FORC60_0064 ENOG4105CRQ synthase (Component I) FORC60_0065 ENOG4105DDQ anthranilate synthase FORC60_0066 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FORC60_0067 ENOG4105EEI dihydropteroate synthase FORC60_0068 ENOG4105KRF dihydroneopterin aldolase FORC60_0069 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FORC60_0071 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FORC60_0076 ENOG4108Z0C Uvrb UvrC protein FORC60_0079 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FORC60_0081 ENOG4105CTP PilT protein domain protein FORC60_0082 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FORC60_0085 ENOG4105D7W serine acetyltransferase FORC60_0088 ENOG4105C2N RNA methyltransferase TrmH family group 3 FORC60_0089 ENOG4105M0M Tetracycline resistance protein FORC60_0090 ENOG4105M0M Tetracycline resistance protein FORC60_0091 ENOG4105QIV RNA polymerase FORC60_0093 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FORC60_0098 ENOG4107Y49 methyltransferase FORC60_0101 ENOG4105XPM ribosomal protein FORC60_0122 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FORC60_0127 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FORC60_0129 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FORC60_0131 ENOG41067V7 50S ribosomal protein L36 FORC60_0136 ENOG4108JJB ABC transporter FORC60_0137 ENOG4108JJB ABC transporter FORC60_0138 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FORC60_0139 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FORC60_0144 ENOG4105D1F ATP-binding protein FORC60_0147 ENOG4108NMV polysaccharide deacetylase FORC60_0151 ENOG4105C8B TIGR00159 family FORC60_0152 ENOG4107U5W ybbr family FORC60_0155 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FORC60_0162 ENOG4108PSK reductase FORC60_0163 ENOG4108UMI ABC transporter, permease FORC60_0164 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FORC60_0165 ENOG4105D01 (LipO)protein FORC60_0167 ENOG4105CB2 alcohol dehydrogenase FORC60_0169 ENOG4105IQ5 FAD linked oxidase domain protein FORC60_0172 ENOG4105C2C drug resistance transporter, Bcr CflA FORC60_0175 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FORC60_0176 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC60_0177 ENOG4105C3U ABC transporter FORC60_0178 ENOG4108JQ7 (ABC) transporter FORC60_0184 ENOG4108J59 Extracellular solute-binding protein, family 5 FORC60_0185 ENOG4108J59 Extracellular solute-binding protein, family 5 FORC60_0189 ENOG4105E0C molybdate abc transporter FORC60_0190 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FORC60_0191 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FORC60_0194 ENOG4105EGI Transcriptional regulator FORC60_0199 ENOG4105F6E Acyl-transferase FORC60_0204 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FORC60_0208 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FORC60_0214 ENOG4105C5H ABC transporter FORC60_0216 ENOG4105DEF Extracellular solute-binding protein, family 5 FORC60_0218 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC60_0219 ENOG4105C3U ABC transporter FORC60_0220 ENOG4108JQ7 (ABC) transporter FORC60_0221 ENOG410667J hydrolase FORC60_0227 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FORC60_0228 ENOG4105ERH Fumarylacetoacetate hydrolase FORC60_0230 ENOG4105CUB amino acid FORC60_0231 ENOG4108SC4 )-transporter FORC60_0232 ENOG4105CPF Cell wall formation (By similarity) FORC60_0233 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FORC60_0238 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FORC60_0239 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FORC60_0241 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FORC60_0245 ENOG4105K8N protein family UPF0079, ATPase FORC60_0246 ENOG41072GX Peptidase M22 Glycoprotease FORC60_0247 ENOG410801F ribosomal-protein-alanine acetyltransferase FORC60_0248 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FORC60_0249 ENOG4105C5H ABC transporter FORC60_0252 ENOG4108TYN CAAX amino terminal protease family protein FORC60_0256 ENOG4105C7N Xanthine uracil vitamin C permease FORC60_0258 ENOG4105BZU Histidine kinase FORC60_0260 ENOG4107ZXU DSBA oxidoreductase FORC60_0266 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC60_0271 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) FORC60_0274 ENOG4105SX7 Transporter FORC60_0277 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FORC60_0278 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FORC60_0279 ENOG4105C83 adenylosuccinate lyase FORC60_0281 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FORC60_0286 ENOG4108V3E phosphoribosylglycinamide formyltransferase FORC60_0288 ENOG4105C12 Phosphoribosylglycinamide synthetase FORC60_0294 ENOG4105C4R Atp-dependent dna helicase FORC60_0299 ENOG4108W2Y isochorismatase FORC60_0300 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FORC60_0301 ENOG4108UMI ABC transporter, permease FORC60_0302 ENOG4105D01 (LipO)protein FORC60_0306 ENOG410834F Transcriptional regulator FORC60_0307 ENOG4107I77 yiaA/B two helix domain FORC60_0311 ENOG4105CBD Diacylglycerol kinase FORC60_0313 ENOG4108JPW Aminotransferase FORC60_0316 ENOG4105C26 Dehydrogenase FORC60_0317 ENOG4105KPY Small multidrug resistance protein FORC60_0323 ENOG4105D9N nucleoside FORC60_0324 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FORC60_0326 ENOG4108W15 Protein of unknown function (DUF1456) FORC60_0329 ENOG4105DTQ mandelate racemase muconate lactonizing FORC60_0331 ENOG4105DFD Na H antiporter FORC60_0335 ENOG4105D3R alkyl hydroperoxide reductase FORC60_0336 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FORC60_0337 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FORC60_0338 ENOG4107W7X Aldolase FORC60_0339 ENOG4105EHG Permease protein FORC60_0340 ENOG4105DQ5 transport system permease protein FORC60_0341 ENOG4108V5C ABC transporter FORC60_0342 ENOG4105CAY ferredoxin--nadp reductase FORC60_0346 ENOG4106UIA FORC60_0347 ENOG4106UIA FORC60_0351 ENOG4105BZU Histidine kinase FORC60_0355 ENOG410756H nucleotidyltransferase FORC60_0356 ENOG4105D2S major facilitator superfamily FORC60_0359 ENOG4105E5Q amino acid AbC transporter FORC60_0360 ENOG4105EAB amino acid AbC transporter FORC60_0362 ENOG4105C8Q Methyl-accepting chemotaxis FORC60_0365 ENOG4105DBV ornithine carbamoyltransferase FORC60_0367 ENOG4105C5B carbamate kinase FORC60_0368 ENOG4108W63 CRP FNR family transcriptional regulator FORC60_0370 ENOG4105DNP FAD linked oxidase domain protein FORC60_0372 ENOG4105CI1 PTS System FORC60_0375 ENOG4105C9U ATP-dependent DNA helicase RecQ FORC60_0378 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FORC60_0382 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FORC60_0383 ENOG4105D2X ABC transporter substrate-binding protein FORC60_0385 ENOG4105C5H ABC transporter FORC60_0391 ENOG41062JF Transcriptional regulator FORC60_0394 ENOG4105DEU major facilitator superfamily FORC60_0397 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FORC60_0400 ENOG4108N0M stress protein FORC60_0401 ENOG4106FN3 tellurium resistance protein FORC60_0402 ENOG4106FN3 tellurium resistance protein FORC60_0403 ENOG4107TS3 membrane protein, TerC FORC60_0404 ENOG4108TTB tellurium resistance protein FORC60_0407 ENOG41068PA UPF0435 protein FORC60_0408 ENOG4105KJF protein tyrosine phosphatase FORC60_0410 ENOG4107U9T Pfam:Ribonuclease_BN FORC60_0412 ENOG4105C59 p-type ATPase FORC60_0413 ENOG4108IPJ Membrane FORC60_0415 ENOG4105C3F Signal peptidase i FORC60_0417 ENOG4107ZTW SNARE associated Golgi FORC60_0420 ENOG410606W general stress protein FORC60_0421 ENOG4105UPD Calcium Proton FORC60_0428 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FORC60_0429 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FORC60_0431 ENOG4108JUB Transcriptional regulator FORC60_0433 ENOG4108IQI permease FORC60_0441 ENOG4108A04 Beta-lactamase FORC60_0444 ENOG4105CKK Glycosyl transferase, family 2 FORC60_0445 ENOG4107QQG Dehydrogenase FORC60_0446 ENOG4105C3I Nad-dependent epimerase dehydratase FORC60_0450 ENOG4105F1A Pyruvate formate-lyase FORC60_0454 ENOG4105CI2 imidazolone-5-propionate hydrolase FORC60_0455 ENOG4105ECP epimerase FORC60_0461 ENOG41067AE Membrane-bound metal-dependent hydrolase FORC60_0462 ENOG4105CEN a g-specific adenine glycosylase FORC60_0463 ENOG4106BXE FORC60_0469 ENOG4105BZ1 (ABC) transporter FORC60_0470 ENOG4107NBY Membrane FORC60_0473 ENOG4108IUW ABC transporter FORC60_0477 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC60_0478 ENOG4105G5W regulator Fur family FORC60_0482 ENOG4105CDY transcriptional regulatory protein FORC60_0484 ENOG4108JQC penicillin-binding protein 1A FORC60_0485 ENOG4108R9S DSBA oxidoreductase FORC60_0486 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FORC60_0488 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FORC60_0489 ENOG4105BZU Histidine kinase FORC60_0491 ENOG4105CYN Serine protein kinase FORC60_0492 ENOG4106AKX UPF0229 protein FORC60_0495 ENOG4105C94 Transporter FORC60_0498 ENOG4105DZ6 Band 7 protein FORC60_0499 ENOG4105DZ6 Band 7 protein FORC60_0501 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FORC60_0502 ENOG4108V9W transcriptional regulatory protein FORC60_0503 ENOG4105D4T Citrate transporter FORC60_0508 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FORC60_0509 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC60_0510 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FORC60_0511 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FORC60_0512 ENOG4105BZ7 extracellular solute-binding protein family 1 FORC60_0514 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FORC60_0515 ENOG4108STX response regulator FORC60_0516 ENOG41062D9 Histidine kinase FORC60_0522 ENOG4108MRH transcriptional regulatory protein FORC60_0524 ENOG4105C6K Malic enzyme FORC60_0527 ENOG4108UZ3 Transporter FORC60_0528 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC60_0530 ENOG4105BZU Histidine kinase FORC60_0534 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FORC60_0535 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FORC60_0536 ENOG4108JB9 formate dehydrogenase FORC60_0543 ENOG4105C59 p-type ATPase FORC60_0544 ENOG4105DAP Nicotinate phosphoribosyltransferase FORC60_0551 ENOG41073R8 VanW family FORC60_0552 ENOG4108KGH TRANSCRIPTIONal FORC60_0553 ENOG4105D9N nucleoside FORC60_0554 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FORC60_0555 ENOG4105C37 (CBS) domain FORC60_0556 ENOG4108IJ0 Aspartate ammonia-lyase FORC60_0557 ENOG4105DAA L-lactate FORC60_0560 ENOG4105DUX Transporter FORC60_0561 ENOG4108MES Periplasmic binding protein FORC60_0562 ENOG4105DQ5 transport system permease protein FORC60_0563 ENOG4108IHU transport system permease protein FORC60_0564 ENOG4105E0A ABC, transporter FORC60_0565 ENOG4105DMQ Methyltransferase FORC60_0566 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FORC60_0567 ENOG4105EXW epimerase dehydratase FORC60_0569 ENOG4107T89 von Willebrand factor, type A FORC60_0570 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FORC60_0571 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FORC60_0573 ENOG4105BZU Histidine kinase FORC60_0574 ENOG4105D5Q Arginine ornithine antiporter FORC60_0575 ENOG4107414 GntR family transcriptional regulator FORC60_0576 ENOG4105C5Y PTS System FORC60_0577 ENOG4105CG3 alpha amylase, catalytic region FORC60_0580 ENOG4105E1K spore germination protein FORC60_0581 ENOG4105CRN Aminoglycoside phosphotransferase FORC60_0582 ENOG4105BZG amino acid carrier protein FORC60_0584 ENOG4105CDA abc transporter atp-binding protein FORC60_0585 ENOG4105CT1 (ABC) transporter FORC60_0586 ENOG4105EAD ABC transporter FORC60_0587 ENOG4105DRP amino acid AbC transporter FORC60_0588 ENOG4108IQI permease FORC60_0591 ENOG4105D29 Helix-turn-helix type 11 domain protein FORC60_0592 ENOG4105NAE bifunctional deaminase-reductase domain protein FORC60_0593 ENOG4105BZU Histidine kinase FORC60_0596 ENOG4105CHH sulfate transporter FORC60_0597 ENOG41068KF Universal stress protein FORC60_0599 ENOG4105CXY transporter FORC60_0601 ENOG41067TZ transcriptional regulator, MarR family FORC60_0602 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC60_0603 ENOG4105ETE Transcriptional regulator (LacI family FORC60_0604 ENOG4108RVA ribokinase FORC60_0606 ENOG4105C2J ABC transporter FORC60_0607 ENOG4105CNN ABC, transporter FORC60_0608 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FORC60_0609 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FORC60_0615 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) FORC60_0621 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FORC60_0622 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FORC60_0623 ENOG41069ER domain protein FORC60_0624 ENOG4105VZ8 Transcriptional regulator FORC60_0625 ENOG4107D63 FORC60_0628 ENOG4105DUX Transporter FORC60_0633 ENOG4105C85 amino acid FORC60_0634 ENOG4105C7N Xanthine uracil vitamin C permease FORC60_0636 ENOG4105D7V transposase FORC60_0639 ENOG4105MA6 gCN5-related N-acetyltransferase FORC60_0643 ENOG4105CCU oxidase (Subunit III) FORC60_0644 ENOG4105BZ9 Cytochrome C oxidase, subunit I FORC60_0645 ENOG4105E2S oxidase) subunit II FORC60_0649 ENOG4106CAD Protein of unknown function (DUF3311) FORC60_0650 ENOG4105E1V na solute symporter FORC60_0653 ENOG4108NHD germination protein FORC60_0655 ENOG4105CE1 Ferrous iron transport protein b FORC60_0656 ENOG4105CE1 Ferrous iron transport protein b FORC60_0657 ENOG4105CE1 Ferrous iron transport protein b FORC60_0658 ENOG4105CVA phosphate FORC60_0659 ENOG4105C8U phosphate abc transporter FORC60_0660 ENOG4105E2Z phosphate ABC transporter (Permease FORC60_0663 ENOG41080XQ Signal transduction protein with cbs domains FORC60_0667 ENOG4105ETU transcriptional activator (TenA FORC60_0669 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FORC60_0671 ENOG4108VEU Thiamine monophosphate synthase FORC60_0672 ENOG41080HI glycine oxidase FORC60_0675 ENOG4105D06 uba thif-type nad fad binding protein FORC60_0676 ENOG4105DWF phosphomethylpyrimidine kinase FORC60_0687 ENOG4108INS Transcriptional regulator FORC60_0689 ENOG4105C7N Xanthine uracil vitamin C permease FORC60_0691 ENOG4108PXI ErfK YbiS YcfS YnhG FORC60_0695 ENOG4105C5Y PTS System FORC60_0698 ENOG4105K63 Thioredoxin FORC60_0702 ENOG4108B31 Spore germination protein FORC60_0706 ENOG4107Y03 Nitroreductase FORC60_0707 ENOG4105ED1 spovr family FORC60_0709 ENOG4108TCS Glutamyl endopeptidase FORC60_0711 ENOG4105J4Q Transcriptional regulator FORC60_0714 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FORC60_0715 ENOG4105XTG Pfam:DUF156 FORC60_0716 ENOG4105VFE sira family FORC60_0717 ENOG4107TPS domain protein FORC60_0718 ENOG4105VFE sira family FORC60_0719 ENOG4105VFE sira family FORC60_0720 ENOG41085GJ domain protein FORC60_0721 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FORC60_0722 ENOG41087NI Sulfite exporter TauE/SafE FORC60_0724 ENOG4108KGH TRANSCRIPTIONal FORC60_0729 ENOG4105EMD TRANSCRIPTIONal FORC60_0730 ENOG4105VCP PTS System FORC60_0731 ENOG4105VZJ PTS System FORC60_0736 ENOG41069ER domain protein FORC60_0737 ENOG4107RBB ABC transporter, permease FORC60_0738 ENOG4105C19 ABC transporter FORC60_0744 ENOG4105WEF catalase FORC60_0751 ENOG4107T5V SNARE associated Golgi FORC60_0758 ENOG4105CUB amino acid FORC60_0759 ENOG4107RWR Sodium hydrogen exchanger FORC60_0761 ENOG4106KNT transcriptional regulator FORC60_0769 ENOG4108YXU transcriptional regulator AsnC family FORC60_0770 ENOG4105CH7 arginosuccinase FORC60_0771 ENOG4108IXY short-chain dehydrogenase reductase FORC60_0773 ENOG4105KPY Small multidrug resistance protein FORC60_0781 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FORC60_0782 ENOG4105E5W Transporter FORC60_0785 ENOG4107RKG DJ-1/PfpI family FORC60_0786 ENOG4105CH6 catalase FORC60_0788 ENOG4105D5Q Arginine ornithine antiporter FORC60_0789 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FORC60_0791 ENOG4105C26 Dehydrogenase FORC60_0792 ENOG4105BZ1 (ABC) transporter FORC60_0793 ENOG4105BZ1 (ABC) transporter FORC60_0795 ENOG4105DRP amino acid AbC transporter FORC60_0796 ENOG4105CDA abc transporter atp-binding protein FORC60_0799 ENOG410839P FORC60_0807 ENOG4107FQX Alpha-acetolactate decarboxylase FORC60_0811 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FORC60_0812 ENOG4105D4P Coproporphyrinogen iii oxidase FORC60_0816 ENOG4105CHH sulfate transporter FORC60_0821 ENOG4105CGU Enoyl-CoA hydratase FORC60_0825 ENOG4105DER m42 family FORC60_0829 ENOG4105CTU Proline racemase FORC60_0830 ENOG4105CIF Ornithine Cyclodeaminase FORC60_0833 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC60_0835 ENOG4108JQ7 (ABC) transporter FORC60_0840 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FORC60_0844 ENOG4105DQ6 Transposase FORC60_0851 ENOG4108IBT Inherit from COG: transposase FORC60_0853 ENOG4105CSH Transporter FORC60_0855 ENOG4108MRH transcriptional regulatory protein FORC60_0859 ENOG4105NI8 Cytosine-specific methyltransferase FORC60_0867 ENOG4105CDU Replicative dna helicase FORC60_0874 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC60_0879 ENOG4105D9U N-acetyltransferase FORC60_0881 ENOG4105F6J Alpha beta hydrolase fold FORC60_0891 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FORC60_0894 ENOG4105CMT Dihydroxyacetone kinase FORC60_0896 ENOG4105CMT Dihydroxyacetone kinase FORC60_0904 ENOG41069ER domain protein FORC60_0919 ENOG4105WN5 stage II sporulation protein FORC60_0921 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC60_0923 ENOG4108MJI response regulator FORC60_0924 ENOG4105BZU Histidine kinase FORC60_0925 ENOG4105BZU Histidine kinase FORC60_0930 ENOG4105K8R UPF0145 protein FORC60_0934 ENOG4107QHE Choloylglycine hydrolase FORC60_0938 ENOG4107VRP DNA repair exonuclease FORC60_0939 ENOG4106D4I domain protein FORC60_0943 ENOG4107JM4 Tetratricopeptide repeat FORC60_0945 ENOG4108MUZ hydrolase FORC60_0950 ENOG4105F0F Oxalate decarboxylase FORC60_0951 ENOG41067QW Transcriptional regulator FORC60_0952 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FORC60_0955 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FORC60_0959 ENOG4105DU6 RNA polymerase FORC60_0962 ENOG4105EEM helicase FORC60_0964 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC60_0970 ENOG4105K59 histidine triad (HIT) protein FORC60_0977 ENOG410905X membrane-flanked domain protein FORC60_0978 ENOG4105CKV Membrane FORC60_0986 ENOG410905X membrane-flanked domain protein FORC60_0987 ENOG4105CKV Membrane FORC60_0988 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FORC60_0989 ENOG4105BZ4 penicillin-binding protein FORC60_0991 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FORC60_0992 ENOG4105C1Q protoporphyrinogen oxidase FORC60_0998 ENOG4105NA0 Transcriptional regulator FORC60_1001 ENOG4105ECB domain protein FORC60_1002 ENOG4105ECB domain protein FORC60_1006 ENOG4108MK9 spermidine N(1)-acetyltransferase FORC60_1008 ENOG4106AXD FORC60_1009 ENOG4108RQ5 Beta-lactamase domain-containing protein FORC60_1010 ENOG4105DF9 Lipoate-protein, ligase FORC60_1012 ENOG4105CEY Amp-dependent synthetase and ligase FORC60_1014 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FORC60_1015 ENOG4108I5D sulfate abc transporter FORC60_1016 ENOG4105ECW sulfate abc transporter FORC60_1017 ENOG4108IJ6 ABC transporter FORC60_1038 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) FORC60_1039 ENOG4107RN3 metallophosphoesterase FORC60_1040 ENOG4107TVP HD domain protein FORC60_1042 ENOG4108AEY RNA polymerase sigma factor FORC60_1043 ENOG41086D8 Transcriptional regulator FORC60_1046 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC60_1050 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FORC60_1051 ENOG4105C8Q Methyl-accepting chemotaxis FORC60_1053 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) FORC60_1055 ENOG4107QP3 malate synthase g FORC60_1059 ENOG4105VEQ Cold shock protein FORC60_1077 ENOG4105ERH Fumarylacetoacetate hydrolase FORC60_1079 ENOG4105C8Y Acetylornithine aminotransferase FORC60_1080 ENOG4106BKT UPF0344 protein FORC60_1082 ENOG4105CAQ asparagine synthetase FORC60_1083 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FORC60_1084 ENOG4105CH6 catalase FORC60_1085 ENOG4105BZU Histidine kinase FORC60_1089 ENOG4108VPT UPF0234 protein FORC60_1090 ENOG4105QNR S1 RNA binding domain protein FORC60_1091 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC60_1093 ENOG4107AYK membrAne FORC60_1094 ENOG41073B9 FORC60_1096 ENOG4108KP7 hydrolase FORC60_1103 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FORC60_1104 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FORC60_1107 ENOG4105C31 Tryptophanyl-tRNA synthetase FORC60_1110 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FORC60_1111 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC60_1113 ENOG4108JQ7 (ABC) transporter FORC60_1114 ENOG4105UQX Mate efflux family protein FORC60_1118 ENOG4108ZCF integral membrane protein FORC60_1120 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FORC60_1122 ENOG4105DPN Oligoendopeptidase f FORC60_1125 ENOG4108Z18 K06886 hemoglobin FORC60_1126 ENOG4105MIX Adenylate cyclase FORC60_1127 ENOG4106EFP UPF0738 protein FORC60_1129 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FORC60_1130 ENOG4105EMS pseudouridine synthase FORC60_1134 ENOG4105K64 Glycosyl transferase, family 2 FORC60_1138 ENOG4107TVC Glycosyl transferase, family 2 FORC60_1142 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FORC60_1143 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FORC60_1145 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FORC60_1155 ENOG4108ZMI UPF0477 protein FORC60_1161 ENOG4105CK7 Sodium proline symporter FORC60_1163 ENOG4105CRQ synthase (Component I) FORC60_1164 ENOG4105DDQ anthranilate synthase FORC60_1168 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FORC60_1183 ENOG4105C7S Dehydrogenase FORC60_1184 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FORC60_1186 ENOG4105VZ8 Transcriptional regulator FORC60_1197 ENOG4105DZ1 carboxypeptidase FORC60_1198 ENOG4105VFR signal peptidase FORC60_1205 ENOG4105C26 Dehydrogenase FORC60_1206 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC60_1207 ENOG4105F38 ABC transporter, permease FORC60_1208 ENOG4105D38 putrescine abc transporter FORC60_1209 ENOG4107RUE extracellular solute-binding protein family 1 FORC60_1211 ENOG4105EYF MMPL domain protein FORC60_1213 ENOG4108YBP pseudouridine synthase FORC60_1215 ENOG4105K4I Scp-like extracellular FORC60_1216 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FORC60_1217 ENOG4105CQB FAD linked oxidase domain protein FORC60_1220 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC60_1221 ENOG4105BZU Histidine kinase FORC60_1222 ENOG4105JXH GntR family transcriptional regulator FORC60_1228 ENOG4108QTI )-transporter FORC60_1229 ENOG4107TS3 membrane protein, TerC FORC60_1230 ENOG4105CZN Potassium uptake protein FORC60_1231 ENOG410681C small acid-soluble spore protein FORC60_1232 ENOG4108Z7G MaoC domain protein dehydratase FORC60_1236 ENOG4105CHR reductase FORC60_1242 ENOG4105C4Y ABC transporter FORC60_1243 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC60_1244 ENOG4107RCV ABC transporter, permease FORC60_1248 ENOG4105E98 transcriptional regulator DeoR family FORC60_1251 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FORC60_1253 ENOG4105PXI polysaccharide deacetylase FORC60_1255 ENOG4105BZU Histidine kinase FORC60_1256 ENOG41090MY MarR family Transcriptional regulator FORC60_1258 ENOG4106DF1 FORC60_1261 ENOG4105BZU Histidine kinase FORC60_1262 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FORC60_1263 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FORC60_1264 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FORC60_1272 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FORC60_1273 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FORC60_1274 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FORC60_1275 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FORC60_1276 ENOG4105CZV ABC transporter FORC60_1278 ENOG4105CJ1 ABC, transporter FORC60_1286 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FORC60_1287 ENOG4105EA8 2-Nitropropane dioxygenase FORC60_1289 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FORC60_1291 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FORC60_1296 ENOG4105NQC Flavodoxin FORC60_1304 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FORC60_1310 ENOG4105CZN Potassium uptake protein FORC60_1311 ENOG41063Y9 FORC60_1312 ENOG4105KBJ sporulation protein ytfj FORC60_1317 ENOG4105CM2 brancheD-chain amino acid aminotransferase FORC60_1318 ENOG4105C7K acetolactate synthase FORC60_1319 ENOG4108ZP8 Acetolactate synthase small subunit FORC60_1320 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FORC60_1323 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FORC60_1327 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FORC60_1328 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FORC60_1333 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase FORC60_1334 ENOG4107RVV histidinol phosphate phosphatase, hisj family FORC60_1337 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FORC60_1338 ENOG4105E0M Sulfatase FORC60_1340 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FORC60_1343 ENOG4107S4M Sulfate adenylate transferase FORC60_1344 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FORC60_1345 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FORC60_1347 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FORC60_1348 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FORC60_1349 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FORC60_1350 ENOG4105C8J )-transporter FORC60_1355 ENOG4105DFD Na H antiporter FORC60_1359 ENOG4105ENE Histidine kinase FORC60_1360 ENOG4105WH1 Two component transcriptional regulator luxr family FORC60_1364 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FORC60_1370 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FORC60_1374 ENOG4105CJ3 phosphate transporter FORC60_1375 ENOG4107GRR phosphate transport regulator FORC60_1376 ENOG4105BZ4 penicillin-binding protein FORC60_1378 ENOG4105BZU Histidine kinase FORC60_1379 ENOG4105I3N Conserved Protein FORC60_1384 ENOG4105BZU Histidine kinase FORC60_1390 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FORC60_1391 ENOG4105DZ1 carboxypeptidase FORC60_1392 ENOG4108JIC nucleoside recognition domain protein FORC60_1394 ENOG4105FE9 pseudouridine synthase FORC60_1395 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC60_1396 ENOG4107TWT Cytochrome c biogenesis protein FORC60_1397 ENOG4105CRE cytochrome C FORC60_1398 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC60_1399 ENOG4105BZU Histidine kinase FORC60_1400 ENOG4108WBT adenosyltransferase FORC60_1403 ENOG4108SAX Membrane FORC60_1406 ENOG4105C9U ATP-dependent DNA helicase RecQ FORC60_1407 ENOG4105I7S Abortive infection protein FORC60_1409 ENOG4107RGJ metallophosphoesterase FORC60_1410 ENOG4108XDN Transcriptional regulator FORC60_1411 ENOG4108S6Z Negative regulator of genetic competence FORC60_1416 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FORC60_1417 ENOG4107RB3 L-asparaginase FORC60_1421 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FORC60_1424 ENOG4105S2F FORC60_1425 ENOG41065D1 FORC60_1432 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FORC60_1435 ENOG4105XXQ heptaprenyl diphosphate synthase component I FORC60_1437 ENOG4105EAH synthase FORC60_1438 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FORC60_1442 ENOG41068YB TPR repeat-containing protein FORC60_1445 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FORC60_1446 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FORC60_1452 ENOG4105DQ6 Transposase FORC60_1455 ENOG4108JYZ YitT family FORC60_1457 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FORC60_1460 ENOG4105FJR Lmbe family FORC60_1461 ENOG4105CPK Glycosyl transferase (Group 1 FORC60_1465 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FORC60_1468 ENOG4105DVT helicase FORC60_1469 ENOG4105YAC FORC60_1473 ENOG4105CSM endonuclease III FORC60_1474 ENOG4105BZ4 penicillin-binding protein FORC60_1485 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FORC60_1494 ENOG4105DVT helicase FORC60_1495 ENOG4105CTD carboxy-peptidase FORC60_1497 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FORC60_1498 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) FORC60_1499 ENOG4105C2W permease FORC60_1500 ENOG4105DHF Membrane FORC60_1502 ENOG410890F Dynamin family FORC60_1504 ENOG4108W0I acetyltransferase FORC60_1506 ENOG4105KHC sulfurtransferase FORC60_1515 ENOG4105HTX biosynthesis protein FORC60_1521 ENOG4105CPK Glycosyl transferase (Group 1 FORC60_1524 ENOG4108SZE gCN5-related N-acetyltransferase FORC60_1528 ENOG41081VK Ribonuclease FORC60_1541 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FORC60_1543 ENOG4107RWR Sodium hydrogen exchanger FORC60_1544 ENOG4105CN5 Metallo-Beta-Lactamase FORC60_1545 ENOG4108Z5V transcriptional regulator, merr family FORC60_1547 ENOG4105H67 Protein of unknown function (DUF421) FORC60_1548 ENOG41080C8 DUF218 domain FORC60_1559 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FORC60_1561 ENOG4107R0U MotA TolQ exbB proton channel FORC60_1562 ENOG4105ER2 Ompa motb domain protein FORC60_1563 ENOG4107YTP response regulator receiver protein FORC60_1564 ENOG4105CBS Chea signal transduction histidine kinase FORC60_1565 ENOG4105DD5 Flagellar motor switch protein FORC60_1568 ENOG4105BZU Histidine kinase FORC60_1572 ENOG4105E1Q flagellar hook-associated protein FORC60_1573 ENOG4105DTJ flagellar hook-associated protein FORC60_1577 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FORC60_1578 ENOG4108ZC9 flagellar basal-body rod protein flgc FORC60_1579 ENOG41075Z6 flagellar hook-basal body complex protein fliE FORC60_1580 ENOG4107U2N Flagellar M-ring protein FORC60_1581 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FORC60_1587 ENOG4105BZE flagellar hook protein, FlgE FORC60_1590 ENOG4107R88 Chemotaxis protein (CheV) FORC60_1594 ENOG4105I03 Flagellin FORC60_1595 ENOG4105E4C Lytic transglycosylase catalytic FORC60_1597 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FORC60_1598 ENOG4105DD5 Flagellar motor switch protein FORC60_1600 ENOG4105CN7 Flagellar biosynthetic protein FliP FORC60_1601 ENOG4105VS8 Flagellar biosynthetic protein fliq FORC60_1603 ENOG4105D00 flagellar biosynthetic protein flhB FORC60_1604 ENOG4105D7B Flagellar biosynthesis protein flha FORC60_1605 ENOG4105FZW flagellar biosynthesis regulator FlhF FORC60_1606 ENOG4105KTQ flagellar basal-body rod protein FORC60_1607 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FORC60_1614 ENOG4105KAC Antibiotic biosynthesis monooxygenase FORC60_1619 ENOG4105DUM transcriptional regulator, lysR family FORC60_1622 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FORC60_1629 ENOG4105CVJ phosphoglycerate mutase FORC60_1631 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FORC60_1635 ENOG4105CAQ asparagine synthetase FORC60_1639 ENOG4105PGM cation diffusion facilitator family transporter FORC60_1641 ENOG4105DRR Transcriptional regulator, GntR family FORC60_1642 ENOG4108UZ3 Transporter FORC60_1644 ENOG4105CKI cobalamin synthesis protein FORC60_1648 ENOG4105DFD Na H antiporter FORC60_1649 ENOG4105VUF Transcriptional regulator FORC60_1651 ENOG4105C9Q fumarate hydratase class II FORC60_1655 ENOG4107QJQ Mate efflux family protein FORC60_1656 ENOG4105EC3 peptidase S51, dipeptidase E FORC60_1660 ENOG4107QIV Cytochrome c biogenesis protein FORC60_1661 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC60_1665 ENOG4106BRA Membrane FORC60_1672 ENOG4105CJ1 ABC, transporter FORC60_1677 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FORC60_1680 ENOG4108IJ0 Aspartate ammonia-lyase FORC60_1681 ENOG4105C6K Malic enzyme FORC60_1695 ENOG4105FVX FORC60_1696 ENOG4105E09 nadh pyrophosphatase FORC60_1699 ENOG4105CSR polyphosphate kinase 2 FORC60_1702 ENOG4105DXI Major Facilitator superfamily FORC60_1705 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FORC60_1706 ENOG4105EU0 Major facilitator Superfamily FORC60_1707 ENOG4105C6T cysteine synthase FORC60_1711 ENOG4105C8J )-transporter FORC60_1714 ENOG4105X5K response regulator receiver protein FORC60_1715 ENOG4105H67 Protein of unknown function (DUF421) FORC60_1720 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FORC60_1721 ENOG4105CHR reductase FORC60_1722 ENOG4105CM2 brancheD-chain amino acid aminotransferase FORC60_1723 ENOG4105C7K acetolactate synthase FORC60_1726 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FORC60_1728 ENOG4105C7B Threonine dehydratase FORC60_1732 ENOG4105C6X Major Facilitator FORC60_1733 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FORC60_1735 ENOG4105DY9 regulatoR FORC60_1736 ENOG4105CYC Transferase FORC60_1737 ENOG4105K5X acetyltransferase FORC60_1741 ENOG41068WN FORC60_1745 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FORC60_1746 ENOG4105C72 UPF0176 protein FORC60_1748 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FORC60_1750 ENOG4105C0X amino acid FORC60_1759 ENOG410849A acetyltransferase, (GNAT) family FORC60_1763 ENOG4107RHR regulatoR FORC60_1765 ENOG4105D9N nucleoside FORC60_1766 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FORC60_1779 ENOG410811B TRANSCRIPTIONal FORC60_1782 ENOG4107RAQ aminopeptidase FORC60_1784 ENOG4107R16 Multicopper oxidase FORC60_1792 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FORC60_1794 ENOG4105DQ6 Transposase FORC60_1804 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FORC60_1805 ENOG4108KP7 hydrolase FORC60_1806 ENOG4105C8V SAICAR synthetase FORC60_1808 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FORC60_1809 ENOG4105CHR reductase FORC60_1811 ENOG4105D9U N-acetyltransferase FORC60_1814 ENOG4108T5E Copper resistance protein FORC60_1815 ENOG4105KTB nuclear export factor GLE1 FORC60_1816 ENOG4107RT3 EamA-like transporter family FORC60_1817 ENOG4105GZI Transcriptional regulator FORC60_1818 ENOG4108Z40 Transcriptional regulator FORC60_1819 ENOG4107ZXU DSBA oxidoreductase FORC60_1820 ENOG4108TVJ Nitroreductase FORC60_1822 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FORC60_1823 ENOG4106F5Q Membrane FORC60_1824 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FORC60_1827 ENOG4105CKI cobalamin synthesis protein FORC60_1829 ENOG4105DQ6 Transposase FORC60_1831 ENOG4105C0Z ABC transporter FORC60_1832 ENOG4108IV0 ABC, transporter FORC60_1833 ENOG4105C32 Amino acid ABC transporter (Permease) FORC60_1835 ENOG4105SKE transcriptional Regulator LysR family FORC60_1842 ENOG4105C4M (Ubiquinol oxidase) subunit I FORC60_1843 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FORC60_1844 ENOG4108JJ9 ABC, transporter FORC60_1845 ENOG4108JJ8 (ABC) transporter FORC60_1847 ENOG4105K64 Glycosyl transferase, family 2 FORC60_1849 ENOG4108UT6 Transferase hexapeptide repeat containing protein FORC60_1860 ENOG4105BZ1 (ABC) transporter FORC60_1861 ENOG4105EFI regulatoR FORC60_1862 ENOG4105BZU Histidine kinase FORC60_1864 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FORC60_1865 ENOG4108ZJ4 polysaccharide deacetylase FORC60_1869 ENOG4105D6E homoserine dehydrogenase FORC60_1874 ENOG4108KGH TRANSCRIPTIONal FORC60_1876 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC60_1877 ENOG4105BZU Histidine kinase FORC60_1878 ENOG4107VMI polysaccharide deacetylase FORC60_1880 ENOG4105KT7 mgtC SapB transporter FORC60_1881 ENOG4105VRR gCN5-related N-acetyltransferase FORC60_1883 ENOG4105DUU IucA IucC family protein FORC60_1884 ENOG4105CEY Amp-dependent synthetase and ligase FORC60_1887 ENOG4108WBH protein TIM barrel FORC60_1888 ENOG4105YWU small acid-soluble spore protein FORC60_1890 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FORC60_1891 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC60_1901 ENOG4105KRN Transcriptional regulator, abrb family FORC60_1903 ENOG4105YVS arsR family transcriptional regulator FORC60_1905 ENOG4107SET aldo keto reductase FORC60_1906 ENOG4107XZQ multidrug resistance protein FORC60_1908 ENOG4105KAF membrAne FORC60_1913 ENOG4105C8Q Methyl-accepting chemotaxis FORC60_1916 ENOG4108K88 Membrane FORC60_1917 ENOG4108WPJ Ferritin-like domain FORC60_1920 ENOG4105DEN Luciferase family FORC60_1923 ENOG4105VMI -acetyltransferase FORC60_1924 ENOG4107QM2 Aldo Keto reductase FORC60_1925 ENOG4105CKI cobalamin synthesis protein FORC60_1927 ENOG4105DSE periplasmic solute binding protein FORC60_1929 ENOG4105K4T epimerase FORC60_1931 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FORC60_1940 ENOG4107T5V SNARE associated Golgi FORC60_1943 ENOG4108PJD permease FORC60_1945 ENOG4108S4H thioesterase Superfamily protein FORC60_1947 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FORC60_1952 ENOG4105SXS Protein of unknown function (DUF456) FORC60_1953 ENOG4105C37 (CBS) domain FORC60_1957 ENOG4108Z7R Chaperone CsaA FORC60_1961 ENOG4108ZRV stage ii sporulation protein p FORC60_1963 ENOG4108VXD carboxy-peptidase FORC60_1968 ENOG4108ZRV stage ii sporulation protein p FORC60_1970 ENOG4108X4Q Hydrolase FORC60_1973 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FORC60_1976 ENOG41087PP glycosyltransferase MGT family FORC60_1977 ENOG4108JYZ YitT family FORC60_1978 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC60_1984 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FORC60_1990 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) FORC60_1991 ENOG4108MGT Required for secretion of EsxA and EsxB FORC60_2010 ENOG4105KBJ sporulation protein ytfj FORC60_2015 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FORC60_2019 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) FORC60_2020 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FORC60_2022 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FORC60_2023 ENOG4105EMN RNA polymerase sigma factor FORC60_2026 ENOG4105CNW domain protein FORC60_2028 ENOG4108V06 Glutathione peroxidase FORC60_2031 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FORC60_2033 ENOG4108IUE nitrate reductase beta subunit FORC60_2034 ENOG4105R3A Nitrate reductase FORC60_2036 ENOG4107V6Q Cyclic nucleotide-binding domain FORC60_2037 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FORC60_2038 ENOG4105D06 uba thif-type nad fad binding protein FORC60_2039 ENOG4105CVM Molybdenum cofactor synthesis domain protein FORC60_2040 ENOG4108ZAF Molybdopterin FORC60_2041 ENOG41067WU Molybdopterin converting factor (Subunit 1) FORC60_2045 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FORC60_2046 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FORC60_2047 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FORC60_2048 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FORC60_2049 ENOG4108IFG nitrite reductase, (NAD(P)H) FORC60_2050 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FORC60_2057 ENOG4105MCT stage V sporulation protein S FORC60_2060 ENOG4105DQ6 Transposase FORC60_2069 ENOG4105C5H ABC transporter FORC60_2072 ENOG4108UUM single-stranded DNA-binding protein FORC60_2076 ENOG4107YX5 Pfam:DUF548 FORC60_2077 ENOG4105C75 arginyL-tRNA synthetase FORC60_2082 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FORC60_2087 ENOG4105C5S asparaginyl-tRNA synthetase FORC60_2088 ENOG4105C8J )-transporter FORC60_2092 ENOG4107XGZ Hydrolase FORC60_2093 ENOG4105CY2 Citrate transporter FORC60_2098 ENOG4105KD7 acetyltransferase FORC60_2100 ENOG4105VMP Transcriptional regulator FORC60_2101 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FORC60_2106 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FORC60_2110 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FORC60_2112 ENOG4107RVG penicillin-binding protein FORC60_2113 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FORC60_2114 ENOG4105E9Q Acyl-transferase FORC60_2115 ENOG4108UT2 hemolysin iii FORC60_2117 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FORC60_2119 ENOG4108RCR degv family FORC60_2122 ENOG4108KF3 Electron transport protein SCO1 SenC FORC60_2123 ENOG4107Y70 Heat shock protein FORC60_2124 ENOG4105CAQ asparagine synthetase FORC60_2128 ENOG4108MES Periplasmic binding protein FORC60_2129 ENOG4105F0I Aminotransferase FORC60_2135 ENOG4105D8X mechanosensitive ion channel FORC60_2136 ENOG4105BZU Histidine kinase FORC60_2137 ENOG4105WH1 Two component transcriptional regulator luxr family FORC60_2138 ENOG4106KNT transcriptional regulator FORC60_2139 ENOG4107ZY0 Phenazine biosynthesis-like protein FORC60_2145 ENOG4105CMG Carbohydrate kinase FORC60_2146 ENOG4105C6Z Gluconate FORC60_2153 ENOG4108IJ8 ABC transporter FORC60_2161 ENOG4105C37 (CBS) domain FORC60_2166 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FORC60_2169 ENOG4107S4Y M20 DapE family protein YgeY FORC60_2170 ENOG4108TSC N-acetyltransferase FORC60_2171 ENOG4108JUB Transcriptional regulator FORC60_2172 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FORC60_2181 ENOG410841Q phosphoesterase PA-phosphatase related protein FORC60_2184 ENOG4105SZ6 Thioredoxin FORC60_2185 ENOG4105KNA -acetyltransferase FORC60_2193 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC60_2205 ENOG4105BZ4 penicillin-binding protein FORC60_2207 ENOG4105CZM Major Facilitator FORC60_2208 ENOG4105W8X HesB YadR YfhF-family protein FORC60_2211 ENOG4105DXD 2-methylcitrate dehydratase FORC60_2212 ENOG4105CR4 methylisocitrate lyase FORC60_2213 ENOG4105C1G acyl-Coa dehydrogenase FORC60_2214 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FORC60_2216 ENOG4105N14 lysine exporter protein LysE YggA FORC60_2217 ENOG4105E39 Enoyl-CoA hydratase FORC60_2220 ENOG4107RFY SbcCD D subunit FORC60_2226 ENOG4105FCD Major Facilitator FORC60_2227 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FORC60_2228 ENOG4105E4F Isochorismate synthase FORC60_2229 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FORC60_2230 ENOG4105WQI isochorismatase FORC60_2231 ENOG4105CEY Amp-dependent synthetase and ligase FORC60_2232 ENOG4105CEY Amp-dependent synthetase and ligase FORC60_2233 ENOG4105WQT MbtH domain protein FORC60_2234 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC60_2237 ENOG4105K70 DNA-binding protein FORC60_2241 ENOG4105BZG amino acid carrier protein FORC60_2245 ENOG4105FE9 pseudouridine synthase FORC60_2246 ENOG4105C22 threonyL-tRNA synthetase FORC60_2247 ENOG4105C19 ABC transporter FORC60_2258 ENOG41081I9 integral membrane protein FORC60_2260 ENOG4108Y4K DNA-binding transcriptional activator FORC60_2262 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) FORC60_2264 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FORC60_2266 ENOG4105EYF MMPL domain protein FORC60_2271 ENOG4105WCN acetyltransferase FORC60_2276 ENOG4105C1Q protoporphyrinogen oxidase FORC60_2278 ENOG41068WN FORC60_2284 ENOG4107V2S Transcriptional regulator FORC60_2285 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FORC60_2289 ENOG4105DND Transcriptional regulator FORC60_2290 ENOG4108RPX mosc domain containing protein FORC60_2293 ENOG4105BZ1 (ABC) transporter FORC60_2294 ENOG4105BZ1 (ABC) transporter FORC60_2302 ENOG4108JCI Transcriptional regulator FORC60_2308 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) FORC60_2309 ENOG4108KPJ rna polymerase sigma factor FORC60_2315 ENOG4105F32 YngK protein FORC60_2319 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) FORC60_2320 ENOG4105RD7 BadF BadG BcrA BcrD FORC60_2321 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FORC60_2323 ENOG4105C7B Threonine dehydratase FORC60_2324 ENOG4108INS Transcriptional regulator FORC60_2328 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FORC60_2330 ENOG4105C1J atp-dependent rna helicase FORC60_2335 ENOG4108RZE Tetr family transcriptional regulator FORC60_2339 ENOG4105VTR Integrase FORC60_2342 ENOG4105DQ6 Transposase FORC60_2348 ENOG4105KIR Thiol-disulfide oxidoreductase dcc FORC60_2362 ENOG41088CC tellurite resistance protein tehB FORC60_2364 ENOG4108I0C methyltransferase FORC60_2365 ENOG4107RA9 decarboxylase FORC60_2366 ENOG41090HR transcriptional regulator FORC60_2367 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FORC60_2372 ENOG4105CIN aminoacyl-histidine dipeptidase FORC60_2378 ENOG4105KRN Transcriptional regulator, abrb family FORC60_2380 ENOG4105EJ9 Membrane FORC60_2381 ENOG4105EQK -acetyltransferase FORC60_2391 ENOG4105W8Z 4'-phosphopantetheinyl transferase FORC60_2393 ENOG4105CHR reductase FORC60_2412 ENOG4108IG5 Transcriptional regulator FORC60_2415 ENOG4105FQP Beta-lactamase FORC60_2420 ENOG4107RF6 penicillin-binding protein FORC60_2421 ENOG4107RF6 penicillin-binding protein FORC60_2423 ENOG4105DIN metallophosphoesterase FORC60_2425 ENOG4105CJ1 ABC, transporter FORC60_2427 ENOG4107Z3H Transcriptional regulator, TetR family FORC60_2430 ENOG4105C1G acyl-Coa dehydrogenase FORC60_2431 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FORC60_2432 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FORC60_2433 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FORC60_2435 ENOG4105E39 Enoyl-CoA hydratase FORC60_2436 ENOG4107QX3 carboxylase FORC60_2437 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FORC60_2442 ENOG4105DBI uridine monophosphokinase FORC60_2444 ENOG4105DZ1 carboxypeptidase FORC60_2447 ENOG4105T9C HD domain FORC60_2449 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FORC60_2453 ENOG41075H3 AraC family transcriptional regulator FORC60_2460 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FORC60_2462 ENOG4107Y80 Major Facilitator superfamily FORC60_2463 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FORC60_2464 ENOG4105KVH Transcriptional regulator FORC60_2474 ENOG4105EFA 4-hydroxyphenylacetate FORC60_2477 ENOG4105CPQ Dehydrogenase FORC60_2479 ENOG410900G Protein of unknown function (DUF421) FORC60_2482 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FORC60_2493 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FORC60_2500 ENOG4105D6E homoserine dehydrogenase FORC60_2502 ENOG4105CPF Cell wall formation (By similarity) FORC60_2503 ENOG4105ETU transcriptional activator (TenA FORC60_2521 ENOG410667J hydrolase FORC60_2522 ENOG4105BZU Histidine kinase FORC60_2523 ENOG4107RF6 penicillin-binding protein FORC60_2528 ENOG4108JJB ABC transporter FORC60_2531 ENOG4108HGU Histidine kinase FORC60_2541 ENOG4105CB2 alcohol dehydrogenase FORC60_2542 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FORC60_2543 ENOG4105CJN penicillin-binding protein FORC60_2554 ENOG4107Y80 Major Facilitator superfamily FORC60_2555 ENOG4108Z5V transcriptional regulator, merr family FORC60_2561 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FORC60_2566 ENOG4107Y9U Membrane FORC60_2575 ENOG4105FCD Major Facilitator FORC60_2577 ENOG4105E09 nadh pyrophosphatase FORC60_2578 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FORC60_2582 ENOG4108XI2 Domain of unknown function (DUF1963) FORC60_2587 ENOG4105D78 K07001 NTE family protein FORC60_2588 ENOG4105KWG Pfam:DUF1696 FORC60_2590 ENOG4108YYS metal-dependent hydrolase (By similarity) FORC60_2593 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FORC60_2595 ENOG4105PKS Excinuclease abc c subunit domain protein FORC60_2603 ENOG4107VFR oxidoreductase FORC60_2611 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC60_2616 ENOG4107WD8 ABC transporter, permease FORC60_2620 ENOG4105DY8 decarboxylase FORC60_2623 ENOG4108IUM Glycogen debranching enzyme FORC60_2625 ENOG4105CGH 5'-nucleotidase FORC60_2628 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FORC60_2629 ENOG4105FDR Membrane FORC60_2631 ENOG4105CIS alcohol dehydrogenase FORC60_2632 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 FORC60_2641 ENOG4105MSI germination protein ypeb FORC60_2647 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) FORC60_2649 ENOG4107Z3H Transcriptional regulator, TetR family FORC60_2656 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FORC60_2660 ENOG4105E98 transcriptional regulator DeoR family FORC60_2663 ENOG41062ES Transcriptional regulator FORC60_2667 ENOG4107QKR Dehydrogenase FORC60_2668 ENOG4107QKR Dehydrogenase FORC60_2670 ENOG4107RUY (E1 component), alpha subunit FORC60_2672 ENOG4105E1F short-chain dehydrogenase reductase FORC60_2673 ENOG4105RHY Pfam:UPF0157 FORC60_2680 ENOG4107SQ8 Glycine betaine FORC60_2681 ENOG4108IJ7 Glycine betaine FORC60_2682 ENOG4108IJ7 Glycine betaine FORC60_2687 ENOG4105E66 phosphoriboisomerase A FORC60_2688 ENOG41082BV acetyltransferase FORC60_2689 ENOG4108M1A Chitin-binding protein FORC60_2695 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FORC60_2701 ENOG4108Z7F N-acetyltransferase FORC60_2710 ENOG41066HZ AIG2-like family FORC60_2711 ENOG4105C9U ATP-dependent DNA helicase RecQ FORC60_2723 ENOG4108M1A Chitin-binding protein FORC60_2727 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FORC60_2729 ENOG4105BZG amino acid carrier protein FORC60_2730 ENOG4105C26 Dehydrogenase FORC60_2731 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FORC60_2732 ENOG4105CTU Proline racemase FORC60_2733 ENOG4105CTU Proline racemase FORC60_2734 ENOG41080HI glycine oxidase FORC60_2736 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FORC60_2743 ENOG4105DCI Phosphohydrolase FORC60_2744 ENOG4107T5V SNARE associated Golgi FORC60_2746 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FORC60_2751 ENOG4105DTQ mandelate racemase muconate lactonizing FORC60_2754 ENOG4107SET aldo keto reductase FORC60_2761 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FORC60_2762 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC60_2763 ENOG4105BZU Histidine kinase FORC60_2764 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC60_2772 ENOG4105DPN Oligoendopeptidase f FORC60_2773 ENOG4105EPR degv family FORC60_2786 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FORC60_2787 ENOG4106K7D Major facilitator family transporter FORC60_2791 ENOG4107BMA Transglycosylase associated protein FORC60_2795 ENOG41089UC methyltransferase, type 11 FORC60_2803 ENOG4105CHM Aminotransferase FORC60_2806 ENOG4108ZMI UPF0477 protein FORC60_2815 ENOG4105C02 permease FORC60_2818 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FORC60_2819 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FORC60_2820 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FORC60_2822 ENOG4105D7T ABC transporter FORC60_2829 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FORC60_2837 ENOG4107VC0 DNA alkylation repair enzyme FORC60_2839 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FORC60_2842 ENOG4108ZCF integral membrane protein FORC60_2843 ENOG4105E0M Sulfatase FORC60_2844 ENOG4105C5H ABC transporter FORC60_2845 ENOG4105EYF MMPL domain protein FORC60_2846 ENOG4105EYF MMPL domain protein FORC60_2847 ENOG41082JN Transcriptional regulator FORC60_2851 ENOG4105CIH Imidazole acetol-phosphate transaminase FORC60_2852 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FORC60_2853 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FORC60_2862 ENOG41069ER domain protein FORC60_2865 ENOG4105DNP FAD linked oxidase domain protein FORC60_2866 ENOG4105C57 major facilitator superfamily FORC60_2867 ENOG4105MKU Transcriptional regulator FORC60_2868 ENOG4105EMN RNA polymerase sigma factor FORC60_2874 ENOG4105F5R ABC transporter FORC60_2875 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FORC60_2877 ENOG4105DKT Transcriptional regulator FORC60_2878 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) FORC60_2880 ENOG41061GT Aldolase FORC60_2883 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FORC60_2892 ENOG4107258 Transcriptional regulator FORC60_2895 ENOG4105ECK Fatty Acid Desaturase FORC60_2897 ENOG4107RBI VanW family FORC60_2898 ENOG4105G6Z alkaline phosphatase FORC60_2900 ENOG4105VMP Transcriptional regulator FORC60_2904 ENOG41068WN FORC60_2910 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FORC60_2914 ENOG4105DQ6 Transposase FORC60_2919 ENOG4105CKK Glycosyl transferase, family 2 FORC60_2925 ENOG4105C8Y Acetylornithine aminotransferase FORC60_2934 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FORC60_2939 ENOG4108IBT Inherit from COG: transposase FORC60_2948 ENOG4108TVJ Nitroreductase FORC60_2949 ENOG4105FS7 Transcriptional regulator FORC60_2952 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FORC60_2955 ENOG4105CMR udp-glucose 4-epimerase FORC60_2957 ENOG4108DMH HTH_ARAC FORC60_2958 ENOG4108XET gCN5-related N-acetyltransferase FORC60_2961 ENOG4108PCN EamA-like transporter family FORC60_2963 ENOG4107XJU UPF0178 protein FORC60_2974 ENOG410635A Membrane FORC60_2976 ENOG4108IQI permease FORC60_2978 ENOG4105F1N DNA alkylation repair FORC60_2980 ENOG4105BZU Histidine kinase FORC60_2981 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC60_2983 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FORC60_2991 ENOG4107RF6 penicillin-binding protein FORC60_2992 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FORC60_2996 ENOG4105E7W lamb ycsf family protein FORC60_2998 ENOG4105P4J Allophanate hydrolase, subunit 1 FORC60_2999 ENOG4107258 Transcriptional regulator FORC60_3001 ENOG4106N3A copper homeostasis protein cutc FORC60_3002 ENOG4108ZHR arsR family transcriptional regulator FORC60_3004 ENOG4105FDT acyl-CoA dehydrogenase FORC60_3008 ENOG4105DWD nucleoside recognition domain protein FORC60_3018 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FORC60_3024 ENOG4105E2A Dehydrogenase FORC60_3025 ENOG4108IJ0 Aspartate ammonia-lyase FORC60_3026 ENOG4105HDK L-asparaginase FORC60_3027 ENOG4108IMY Transcriptional regulator FORC60_3030 ENOG4108B31 Spore germination protein FORC60_3032 ENOG4105BZU Histidine kinase FORC60_3037 ENOG41075H3 AraC family transcriptional regulator FORC60_3040 ENOG4105YWU small acid-soluble spore protein FORC60_3041 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FORC60_3042 ENOG4105CUB amino acid FORC60_3043 ENOG4105CUB amino acid FORC60_3044 ENOG4105II7 pyrroline-5-carboxylate reductase FORC60_3045 ENOG4108NHD germination protein FORC60_3046 ENOG4108Q8B Spore germination protein FORC60_3051 ENOG4105CSV Glutaminase FORC60_3057 ENOG4105CGH 5'-nucleotidase FORC60_3059 ENOG4105CHJ isochorismatase hydrolase FORC60_3064 ENOG41090MY MarR family Transcriptional regulator FORC60_3071 ENOG4105F6J Alpha beta hydrolase fold FORC60_3074 ENOG4108606 TspO/MBR family FORC60_3075 ENOG4105CVP deoxyribo-dipyrimidine photolyase FORC60_3079 ENOG4105F2M alpha beta hydrolase fold-3 domain protein FORC60_3082 ENOG4108TWJ NADH dehydrogenase subunit 5 FORC60_3083 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FORC60_3084 ENOG4107VMI polysaccharide deacetylase FORC60_3085 ENOG4108U7W acetyltransferase FORC60_3086 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FORC60_3087 ENOG4105ECQ AraC Family Transcriptional Regulator FORC60_3091 ENOG4105D6J arsenicaL-resistance protein FORC60_3092 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FORC60_3093 ENOG41085FC arsR family transcriptional regulator FORC60_3095 ENOG4105NAE bifunctional deaminase-reductase domain protein FORC60_3096 ENOG4107P5I polyketide synthase FORC60_3097 ENOG4108IG5 Transcriptional regulator FORC60_3105 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC60_3106 ENOG41062D9 Histidine kinase FORC60_3114 ENOG4105DNP FAD linked oxidase domain protein FORC60_3116 ENOG4105C19 ABC transporter FORC60_3122 ENOG4105DQ6 Transposase FORC60_3125 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FORC60_3126 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC60_3135 ENOG4105JQZ Methyltransferase FORC60_3139 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FORC60_3143 ENOG4105BZU Histidine kinase FORC60_3146 ENOG4108U05 Transcriptional regulator FORC60_3147 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 FORC60_3149 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FORC60_3157 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FORC60_3191 ENOG4108VXD carboxy-peptidase FORC60_3192 ENOG4105PNM synthesis protein FORC60_3194 ENOG4108ISG Major Facilitator FORC60_3197 ENOG4107MII Sugar-specific transcriptional regulator TrmB FORC60_3198 ENOG4105CZM Major Facilitator FORC60_3201 ENOG4105CRW Short chain fatty acid transporter FORC60_3203 ENOG4108X0B nad(p)h dehydrogenase (quinone) FORC60_3215 ENOG4108K8S endonuclease I FORC60_3219 ENOG4108Z66 YbaK ebsC protein FORC60_3220 ENOG4105CUT histidyl-tRNA synthetase FORC60_3223 ENOG4105KVH Transcriptional regulator FORC60_3224 ENOG4108RCM Nitroreductase FORC60_3230 ENOG4108PSK reductase FORC60_3243 ENOG4105C31 Tryptophanyl-tRNA synthetase FORC60_3244 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FORC60_3252 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) FORC60_3260 ENOG4105C37 (CBS) domain FORC60_3263 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FORC60_3264 ENOG4105FAW cDP-glucose 4,6-dehydratase FORC60_3271 ENOG4105DDN Pentapeptide repeat-containing protein FORC60_3272 ENOG4105XDF Protein of unknown function (DUF1272) FORC60_3273 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FORC60_3274 ENOG4105CMG Carbohydrate kinase FORC60_3275 ENOG4105C6Z Gluconate FORC60_3276 ENOG4105C6Z Gluconate FORC60_3277 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FORC60_3280 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FORC60_3281 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FORC60_3285 ENOG4105C8Q Methyl-accepting chemotaxis FORC60_3287 ENOG4108UX3 '-nucleotidase FORC60_3288 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FORC60_3289 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) FORC60_3290 ENOG4105KVH Transcriptional regulator FORC60_3294 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FORC60_3295 ENOG4105CHH sulfate transporter FORC60_3298 ENOG4105C44 Serine transporter FORC60_3303 ENOG4108TZY GntR Family Transcriptional Regulator FORC60_3304 ENOG4105D9R oxidoreductase FORC60_3313 ENOG4105JAB phenazine biosynthesis protein, phzf family FORC60_3315 ENOG4105CHR reductase FORC60_3317 ENOG4105KNA -acetyltransferase FORC60_3319 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FORC60_3320 ENOG4105KVH Transcriptional regulator FORC60_3339 ENOG4105DQ6 Transposase FORC60_3342 ENOG4105CNA YD repeat protein FORC60_3344 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FORC60_3351 ENOG4105H3G oxidoreductase FORC60_3365 ENOG4108TN2 lmbE family FORC60_3367 ENOG4107R3E Citrate transporter FORC60_3369 ENOG4105WCN acetyltransferase FORC60_3370 ENOG4108MES Periplasmic binding protein FORC60_3371 ENOG4105EHG Permease protein FORC60_3372 ENOG4105DQ5 transport system permease protein FORC60_3373 ENOG4105NX3 Membrane FORC60_3378 ENOG4105D9U N-acetyltransferase FORC60_3379 ENOG4107CUJ Protein of unknown function (DUF2690) FORC60_3381 ENOG4107V2S Transcriptional regulator FORC60_3385 ENOG4105C98 muts2 protein FORC60_3386 ENOG4105E5K Alpha-amylase FORC60_3387 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FORC60_3388 ENOG4105DPN Oligoendopeptidase f FORC60_3394 ENOG4108A04 Beta-lactamase FORC60_3399 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FORC60_3402 ENOG41082BM Transcriptional regulator, arsr family FORC60_3403 ENOG4105CIS alcohol dehydrogenase FORC60_3409 ENOG4105CQB FAD linked oxidase domain protein FORC60_3414 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FORC60_3417 ENOG4107TPS domain protein FORC60_3418 ENOG4105CEP NADH dehydrogenase FORC60_3420 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C FORC60_3421 ENOG4108M1A Chitin-binding protein FORC60_3429 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FORC60_3431 ENOG4108IAJ Nad-dependent epimerase dehydratase FORC60_3432 ENOG4105FAW cDP-glucose 4,6-dehydratase FORC60_3448 ENOG4105BZU Histidine kinase FORC60_3449 ENOG4105C5H ABC transporter FORC60_3451 ENOG4107DUR UPF0457 protein FORC60_3456 ENOG4105BZU Histidine kinase FORC60_3458 ENOG4105KT7 mgtC SapB transporter FORC60_3460 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FORC60_3461 ENOG41073R8 VanW family FORC60_3463 ENOG4108R1P FORC60_3467 ENOG4105VEQ Cold shock protein FORC60_3471 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FORC60_3475 ENOG410904N short-chain dehydrogenase reductase FORC60_3480 ENOG4108IA2 Sodium pantothenate symporter FORC60_3482 ENOG4105C26 Dehydrogenase FORC60_3483 ENOG4105CHR reductase FORC60_3485 ENOG4105EWU Squalene--hopene cyclase FORC60_3487 ENOG4105FR1 rard protein FORC60_3488 ENOG410696E Membrane FORC60_3491 ENOG4105D1F ATP-binding protein FORC60_3493 ENOG4108ZAF Molybdopterin FORC60_3494 ENOG4105CVM Molybdenum cofactor synthesis domain protein FORC60_3495 ENOG4105D06 uba thif-type nad fad binding protein FORC60_3496 ENOG4105TMB Formate nitrite transporter FORC60_3498 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FORC60_3499 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FORC60_3501 ENOG4108JB9 formate dehydrogenase FORC60_3502 ENOG4105E1K spore germination protein FORC60_3505 ENOG4105CUB amino acid FORC60_3517 ENOG4107QJT sodium dicarboxylate symporter FORC60_3518 ENOG4108KGH TRANSCRIPTIONal FORC60_3520 ENOG4105EMN RNA polymerase sigma factor FORC60_3522 ENOG4105CIG ABC transporter FORC60_3524 ENOG4105D9R oxidoreductase FORC60_3526 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FORC60_3527 ENOG4105K4P CoA-binding domain protein FORC60_3528 ENOG4105C0H protease FORC60_3529 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC60_3531 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FORC60_3532 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FORC60_3533 ENOG4105W8X HesB YadR YfhF-family protein FORC60_3539 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FORC60_3540 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC60_3543 ENOG4105BZ1 (ABC) transporter FORC60_3544 ENOG4108I0Z Aconitate hydratase FORC60_3550 ENOG4105E5W Transporter FORC60_3552 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FORC60_3557 ENOG4107ZYJ bioY protein FORC60_3558 ENOG4105CEY Amp-dependent synthetase and ligase FORC60_3567 ENOG4107AYK membrAne FORC60_3570 ENOG4105BZU Histidine kinase FORC60_3571 ENOG4105FBA Phospholipase Carboxylesterase FORC60_3572 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FORC60_3573 ENOG4105CK7 Sodium proline symporter FORC60_3575 ENOG4105CBC glutamate synthase FORC60_3576 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FORC60_3577 ENOG4108VJ1 Transcriptional regulator (CarD family FORC60_3578 ENOG4108903 Formimidoylglutamase FORC60_3589 ENOG4107QIV Cytochrome c biogenesis protein FORC60_3593 ENOG4105CH2 amidohydrolase FORC60_3598 ENOG4107RSM transcriptional regulator FORC60_3599 ENOG4105VAW lrga family FORC60_3600 ENOG41067MG lrgb family FORC60_3608 ENOG4105BZ1 (ABC) transporter FORC60_3616 ENOG4108HW3 (ABC) transporter FORC60_3617 ENOG4105CGH 5'-nucleotidase FORC60_3619 ENOG4108SVB resolvase FORC60_3623 ENOG4105K7K Transcriptional regulator FORC60_3625 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FORC60_3626 ENOG4105DR5 peptidase FORC60_3627 ENOG41065S2 pneumococcal vaccine antigen FORC60_3634 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FORC60_3640 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FORC60_3646 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FORC60_3647 ENOG4105XSJ toxin secretion phage lysis holin FORC60_3679 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FORC60_3691 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) FORC60_3725 ENOG4105XSJ toxin secretion phage lysis holin FORC60_3740 ENOG4105C5F glutamine synthetase FORC60_3741 ENOG4105KV4 Transcriptional regulator FORC60_3743 ENOG4105CXI aluminum resistance protein FORC60_3744 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FORC60_3745 ENOG4105EN6 Membrane FORC60_3747 ENOG4106F1P AAA ATPase, central domain protein FORC60_3756 ENOG41069ER domain protein FORC60_3757 ENOG4105DM4 PTS System FORC60_3758 ENOG4105DE4 1-phosphofructokinase FORC60_3759 ENOG4105E98 transcriptional regulator DeoR family FORC60_3760 ENOG4107QW4 alcohol dehydrogenase FORC60_3761 ENOG4108SJC Membrane FORC60_3764 ENOG4105C85 amino acid FORC60_3767 ENOG4105TMB Formate nitrite transporter FORC60_3768 ENOG4105K70 DNA-binding protein FORC60_3770 ENOG4105C59 p-type ATPase FORC60_3771 ENOG410681U heavy metal transport detoxification protein FORC60_3772 ENOG4105VPX protein, conserved in bacteria FORC60_3774 ENOG4105NIV Esterase FORC60_3775 ENOG4105E0A ABC, transporter FORC60_3781 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FORC60_3782 ENOG4105D03 DNA-3-methyladenine glycosylase II FORC60_3787 ENOG4105BZU Histidine kinase FORC60_3795 ENOG41067MG lrgb family FORC60_3800 ENOG4108S3Y transcriptional regulator FORC60_3801 ENOG4105CS2 ec 3.2.1.21 FORC60_3803 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C FORC60_3805 ENOG4105F0V Cell wall hydrolase FORC60_3807 ENOG4105E0M Sulfatase FORC60_3808 ENOG410890F Dynamin family FORC60_3816 ENOG4105DQU oxidoreductase, subunit beta FORC60_3817 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FORC60_3818 ENOG4108IGT Dipeptidase FORC60_3819 ENOG4105MCT stage V sporulation protein S FORC60_3820 ENOG4105D48 metallophosphoesterase FORC60_3824 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FORC60_3827 ENOG4105XZV Protein of unknown function (DUF3243) FORC60_3828 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FORC60_3832 ENOG4105UIB (ABC) transporter FORC60_3833 ENOG4108JQ9 ABC transporter FORC60_3834 ENOG4105DIH basic membrane FORC60_3835 ENOG4105FDP GntR family transcriptional regulator FORC60_3836 ENOG4105CNU cell division protein FtsK FORC60_3838 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FORC60_3841 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FORC60_3843 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FORC60_3844 ENOG4108S0H Dipicolinic acid synthetase, b subunit FORC60_3882 ENOG4105CDU Replicative dna helicase FORC60_3897 ENOG4108S0H Dipicolinic acid synthetase, b subunit FORC60_3898 ENOG4105E35 Dipicolinate synthase subunit A FORC60_3900 ENOG4105C1V Peptidase, M16 FORC60_3904 ENOG4105DTN riboflavin biosynthesis protein ribF FORC60_3907 ENOG4105W7A Protein of unknown function (DUF503) FORC60_3909 ENOG4105VHM ribosomal protein FORC60_3910 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FORC60_3911 ENOG4105CHV Transcription elongation factor NusA FORC60_3913 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FORC60_3915 ENOG4105DZP Membrane-associated zinc metalloprotease FORC60_3916 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FORC60_3917 ENOG4105KNE Phosphatidate cytidylyltransferase FORC60_3919 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FORC60_3921 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FORC60_3927 ENOG4108HE4 integrase family FORC60_3929 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FORC60_3930 ENOG4105C79 DNA protecting protein DprA FORC60_3931 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FORC60_3934 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FORC60_3939 ENOG4105VB6 UPF0109 protein FORC60_3943 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FORC60_3944 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FORC60_3947 ENOG4105CHR reductase FORC60_3948 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FORC60_3951 ENOG4105CB5 ATP-dependent DNA helicase recG FORC60_3952 ENOG4105DP4 dak2 domain fusion protein ylov FORC60_3953 ENOG4108ZAA Alkaline-shock protein FORC60_3956 ENOG4105FJ0 thiamine FORC60_3957 ENOG4105DJV ribulose-phosphate 3-epimerase FORC60_3958 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FORC60_3959 ENOG4105D9P serine threonine protein kinase FORC60_3960 ENOG4108ZF3 Phosphatase FORC60_3962 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FORC60_3965 ENOG4105C25 Primosomal protein n' FORC60_3966 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FORC60_3970 ENOG4105DSJ YicC domain protein FORC60_3972 ENOG4105F23 Fibronectin-binding protein FORC60_3974 ENOG4105DC7 peptidase M24 FORC60_3979 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FORC60_3982 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) FORC60_3983 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FORC60_3985 ENOG4105CD3 dihydroorotase FORC60_3989 ENOG4105C34 Pseudouridine synthase FORC60_3992 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FORC60_3994 ENOG4105DBK s4 domain protein FORC60_3995 ENOG41067XK integral membrane protein FORC60_3997 ENOG4105DFA alanine racemase domain protein FORC60_3998 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FORC60_3999 ENOG4105WR5 sporulation protein, YlmC YmxH family FORC60_4001 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC60_4003 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FORC60_4004 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FORC60_4007 ENOG4105D4A Cell wall formation (By similarity) FORC60_4008 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FORC60_4009 ENOG4105CNI cell division protein FtsW FORC60_4012 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FORC60_4013 ENOG4105CJN penicillin-binding protein FORC60_4014 ENOG4105CJN penicillin-binding protein FORC60_4017 ENOG41074B2 UPF0747 protein FORC60_4022 ENOG4105KNH Nucleic acid-binding protein FORC60_4024 ENOG41063PX domain protein FORC60_4025 ENOG4105D78 K07001 NTE family protein FORC60_4026 ENOG4105H20 Sporulation integral membrane protein YlbJ FORC60_4028 ENOG4106H78 methyltransferase FORC60_4032 ENOG4107TB6 phosphoglycerate mutase FORC60_4035 ENOG4106UY4 Inherit from COG: Scp-like extracellular FORC60_4047 ENOG4105CNI cell division protein FtsW FORC60_4050 ENOG4108IAB Phoh family FORC60_4054 ENOG4105QA2 FORC60_4055 ENOG4105CI3 gtp-binding protein typa FORC60_4057 ENOG4105ECY inositol monophosphatase FORC60_4062 ENOG4105CXN decarboxylase FORC60_4072 ENOG4105CPP Dehydrogenase, E1 component FORC60_4075 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FORC60_4076 ENOG4108X4Q Hydrolase FORC60_4078 ENOG4105CN5 Metallo-Beta-Lactamase FORC60_4079 ENOG4107ZYR domain protein FORC60_4086 ENOG4108XRC Protein of unknown function (DUF458) FORC60_4088 ENOG4107IN1 Protein of unknown function (DUF1797) FORC60_4091 ENOG4105EPM Diguanylate phosphodiesterase FORC60_4092 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FORC60_4095 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FORC60_4097 ENOG4105UIN FORC60_4109 ENOG4108HGU Histidine kinase FORC60_4112 ENOG4105CHM Aminotransferase FORC60_4113 ENOG4105FKQ transcriptional regulator FORC60_4114 ENOG4105EG2 ABC transporter, permease FORC60_4116 ENOG4107FKK extracellular solute-binding protein family 1 FORC60_4118 ENOG4105CG3 alpha amylase, catalytic region FORC60_4127 ENOG4105CHU acetyl-coa acetyltransferase FORC60_4134 ENOG4105K7K Transcriptional regulator FORC60_4135 ENOG4105DTD Dehydrogenase FORC60_4139 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FORC60_4144 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FORC60_4147 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FORC60_4149 ENOG4105BZU Histidine kinase FORC60_4153 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FORC60_4156 ENOG4105CID antiterminator FORC60_4158 ENOG4105FDP GntR family transcriptional regulator FORC60_4160 ENOG4105CE4 GlcNAc 6-P deacetylase FORC60_4167 ENOG4107ZE5 PPIases accelerate the folding of proteins FORC60_4168 ENOG4105PTM secreted protein FORC60_4169 ENOG4105J7I hydrolase FORC60_4171 ENOG4105G6R Stage v sporulation protein ae FORC60_4173 ENOG4105CZ3 stage V sporulation protein ad FORC60_4174 ENOG41090VF Stage v sporulation protein ac FORC60_4178 ENOG4105C8J )-transporter FORC60_4179 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC60_4181 ENOG41082AN stage II sporulation protein FORC60_4182 ENOG4105DZ1 carboxypeptidase FORC60_4183 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FORC60_4184 ENOG4105DVE abc transporter atp-binding protein FORC60_4191 ENOG4105D7N magnesium and cobalt transport protein CorA FORC60_4196 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FORC60_4198 ENOG4105I3K Ferric uptake regulator, Fur family FORC60_4199 ENOG4105MZ9 stage II sporulation protein m FORC60_4203 ENOG4105CPC Aldo Keto reductase FORC60_4205 ENOG4105RHY Pfam:UPF0157 FORC60_4209 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FORC60_4211 ENOG4105ETE Transcriptional regulator (LacI family FORC60_4212 ENOG4108YM7 Gcn5-related n-acetyltransferase FORC60_4216 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FORC60_4217 ENOG4108R6K riboflavin synthase, subunit alpha FORC60_4222 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FORC60_4223 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FORC60_4226 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FORC60_4228 ENOG4105DFD Na H antiporter FORC60_4229 ENOG4105CGH 5'-nucleotidase FORC60_4234 ENOG4105DBV ornithine carbamoyltransferase FORC60_4237 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FORC60_4240 ENOG4108IXY short-chain dehydrogenase reductase FORC60_4241 ENOG41069FQ Metallo-beta-lactamase superfamily FORC60_4242 ENOG4105II7 pyrroline-5-carboxylate reductase FORC60_4243 ENOG4105EJQ L-serine dehydratase FORC60_4246 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FORC60_4249 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FORC60_4252 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FORC60_4253 ENOG4105D9U N-acetyltransferase FORC60_4256 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FORC60_4257 ENOG4108QEG Membrane FORC60_4258 ENOG4105CDA abc transporter atp-binding protein FORC60_4259 ENOG4105E5Q amino acid AbC transporter FORC60_4260 ENOG4108HW3 (ABC) transporter FORC60_4262 ENOG4105G7B Protein of unknown function (DUF2992) FORC60_4264 ENOG4108QY0 Membrane FORC60_4266 ENOG4105C7S Dehydrogenase FORC60_4267 ENOG4105CPP Dehydrogenase, E1 component FORC60_4270 ENOG4105CKM Branched-chain carboxylic acid kinase FORC60_4271 ENOG4107RDP Dehydrogenase FORC60_4274 ENOG4108JUB Transcriptional regulator FORC60_4276 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FORC60_4280 ENOG4107QQR Sporulation FORC60_4281 ENOG4105S1Z Stage IV sporulation protein B FORC60_4282 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FORC60_4283 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FORC60_4284 ENOG4105DX0 Hemolysin A FORC60_4286 ENOG4105CTB Polyprenyl synthetase FORC60_4289 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FORC60_4291 ENOG4108ZSR alkaline shock protein FORC60_4292 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FORC60_4296 ENOG410644B Stage III sporulation protein af FORC60_4298 ENOG4105KQ4 Stage iii sporulation protein ad FORC60_4299 ENOG4108CQH stage III sporulation protein AC FORC60_4300 ENOG4105KR5 Stage iii sporulation protein FORC60_4301 ENOG4105CD2 stage iii sporulation protein aa FORC60_4306 ENOG4105DC7 peptidase M24 FORC60_4309 ENOG4105CBJ Metal-dependent enzyme FORC60_4311 ENOG4107YBY Hydrolase FORC60_4314 ENOG4105K7K Transcriptional regulator FORC60_4317 ENOG41082GG biotin lipoate A B protein ligase FORC60_4318 ENOG4105WZW rhodanese family FORC60_4323 ENOG41080TC multidrug resistance protein FORC60_4330 ENOG4105CJ1 ABC, transporter FORC60_4331 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FORC60_4333 ENOG4105DQ6 Transposase FORC60_4336 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FORC60_4340 ENOG4105C0D helicase FORC60_4358 ENOG4107R6U sodium dicarboxylate symporter FORC60_4365 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FORC60_4366 ENOG4105C3R Methionine synthase FORC60_4369 ENOG4105C28 cystathionine FORC60_4373 ENOG4105C5X domain protein FORC60_4375 ENOG4105DKQ ROK family FORC60_4377 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FORC60_4380 ENOG4108UTW Plays a role in the regulation of phosphate uptake FORC60_4381 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FORC60_4382 ENOG4105C8U phosphate abc transporter FORC60_4383 ENOG4105C8U phosphate abc transporter FORC60_4384 ENOG4105EXS phosphate abc transporter FORC60_4385 ENOG4107RF6 penicillin-binding protein FORC60_4387 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FORC60_4392 ENOG4105N80 Ferric uptake regulator, Fur family FORC60_4394 ENOG4105FDK ABC transporter FORC60_4395 ENOG4108JYZ YitT family FORC60_4396 ENOG41069ZM Protein of unknown function (DUF2624) FORC60_4401 ENOG4105EGD dinuclear metal center protein, YbgI family FORC60_4404 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC60_4405 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FORC60_4408 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) FORC60_4412 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FORC60_4413 ENOG4105KG3 cytidine deaminase FORC60_4414 ENOG4107YR5 Diacylglycerol kinase FORC60_4415 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FORC60_4416 ENOG4105CTJ Metal Dependent Phosphohydrolase FORC60_4417 ENOG4105C9A Phoh family FORC60_4419 ENOG41068P3 sporulation protein YqfC FORC60_4421 ENOG4105KTH gatB Yqey FORC60_4424 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FORC60_4425 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FORC60_4431 ENOG4105CSA Coproporphyrinogen iii oxidase FORC60_4432 ENOG4105KVH Transcriptional regulator FORC60_4437 ENOG4105TQK DNA polymerase iii, delta' subunit FORC60_4440 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FORC60_4442 ENOG4108UK2 deaminase FORC60_4443 ENOG4105KQC Competence protein FORC60_4445 ENOG4105DXX methyltransferase FORC60_4447 ENOG4108WF2 Metal Dependent Phosphohydrolase FORC60_4449 ENOG410812S Rna-binding protein FORC60_4451 ENOG4105CQW ribosome biogenesis GTPase YqeH FORC60_4452 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FORC60_4455 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC60_4459 ENOG4108TVJ Nitroreductase FORC60_4463 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FORC60_4464 ENOG4108MUZ hydrolase FORC60_4471 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FORC60_4473 ENOG4105MIR Phenylalanine 4-monooxygenase FORC60_4475 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FORC60_4483 ENOG4105S6R Iron-hydroxamate transporter permease subunit FORC60_4484 ENOG4108V5C ABC transporter FORC60_4486 ENOG4108EKI Dehydrogenase FORC60_4487 ENOG4105C28 cystathionine FORC60_4493 ENOG4107XRG penicillin-binding protein FORC60_4495 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FORC60_4498 ENOG4105CFP Peptidase U32 FORC60_4499 ENOG4105XYU peptidase (U32 family) FORC60_4500 ENOG4108VQJ O-methyltransferase FORC60_4501 ENOG4105HHA aminodeoxychorismate lyase FORC60_4505 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FORC60_4507 ENOG4105C02 permease FORC60_4510 ENOG41060CR FORC60_4511 ENOG4105C7H Helicase, RecD TraA family FORC60_4513 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FORC60_4514 ENOG4105C3J Cysteine desulfurase FORC60_4516 ENOG4105D1H recombination factor protein RarA FORC60_4517 ENOG4108VCI transcription factor, rsfa family FORC60_4518 ENOG4105CUZ uba thif-type nad fad binding protein FORC60_4520 ENOG4105CUT histidyl-tRNA synthetase FORC60_4523 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FORC60_4525 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FORC60_4526 ENOG41076HS cation diffusion facilitator family transporter FORC60_4527 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FORC60_4529 ENOG4105CKP Polysaccharide Biosynthesis Protein FORC60_4530 ENOG4108QG2 Membrane FORC60_4532 ENOG4105VIE preprotein translocase, subunit YajC FORC60_4535 ENOG41061AI Protein of unknown function (DUF2905) FORC60_4538 ENOG4108HUF Transporter FORC60_4544 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FORC60_4545 ENOG4108IYU L-aspartate oxidase FORC60_4548 ENOG4108RPX mosc domain containing protein FORC60_4549 ENOG4105CQC Prephenate dehydratase FORC60_4552 ENOG4105C19 ABC transporter FORC60_4553 ENOG4105EWM Histidine kinase FORC60_4555 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FORC60_4558 ENOG4105X36 (ribosomal) protein FORC60_4563 ENOG4107QMS site-determining protein FORC60_4566 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FORC60_4567 ENOG4105DFF Rod shape-determining protein mreb FORC60_4571 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FORC60_4572 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FORC60_4574 ENOG41068KH stage VI sporulation protein D FORC60_4576 ENOG4105D52 delta-aminolevulinic acid dehydratase FORC60_4581 ENOG4105K56 Transcriptional regulator FORC60_4585 ENOG4108IUQ atp-dependent protease FORC60_4592 ENOG4108QCI YvbH-like oligomerisation region FORC60_4594 ENOG4105M59 Phosphodiesterase, mj0936 family FORC60_4595 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FORC60_4597 ENOG4108XJQ germination protein FORC60_4600 ENOG4108PCX Major Facilitator FORC60_4602 ENOG4105KBX Transcriptional regulator, TetR family FORC60_4604 ENOG4105PFC Transcriptional regulator FORC60_4607 ENOG4105DZC cytosine deaminase FORC60_4608 ENOG41067S9 phage shock protein C, PspC FORC60_4609 ENOG4108JCI Transcriptional regulator FORC60_4611 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FORC60_4612 ENOG4108Z40 Transcriptional regulator FORC60_4613 ENOG4105RHA ABC transporter, permease FORC60_4614 ENOG4108IUX (ABC) transporter FORC60_4615 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FORC60_4616 ENOG4105ER2 Ompa motb domain protein FORC60_4617 ENOG4105E14 MotA TolQ exbB proton channel FORC60_4618 ENOG4108VXD carboxy-peptidase FORC60_4620 ENOG4105E33 succinate dehydrogenase FORC60_4622 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FORC60_4624 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FORC60_4625 ENOG4105K63 Thioredoxin FORC60_4626 ENOG4105C10 Electron transfer flavoprotein FORC60_4627 ENOG4105BZJ Electron transfer flavoprotein FORC60_4628 ENOG41060WC Enoyl-CoA hydratase FORC60_4629 ENOG4107Z3H Transcriptional regulator, TetR family FORC60_4630 ENOG4105CEY Amp-dependent synthetase and ligase FORC60_4632 ENOG4105J76 Periplasmic binding protein FORC60_4633 ENOG4105S6R Iron-hydroxamate transporter permease subunit FORC60_4643 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC60_4646 ENOG4105DR4 Methyltransferase FORC60_4648 ENOG4105KFN sortase, SrtB family FORC60_4649 ENOG4105E0A ABC, transporter FORC60_4652 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FORC60_4654 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FORC60_4657 ENOG4105FE9 pseudouridine synthase FORC60_4660 ENOG4105DCG PHP domain protein FORC60_4663 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FORC60_4667 ENOG4105C5S asparaginyl-tRNA synthetase FORC60_4668 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FORC60_4670 ENOG4108RWN rrna methyltransferase FORC60_4676 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC60_4677 ENOG4105CW7 secretion protein, HlyD family FORC60_4678 ENOG4108JGH Tetr family transcriptional regulator FORC60_4679 ENOG4105CN9 Peptidase m42 family protein FORC60_4683 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FORC60_4684 ENOG4105C22 threonyL-tRNA synthetase FORC60_4685 ENOG4108TDW sporulation protein YtxC FORC60_4690 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FORC60_4692 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FORC60_4693 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FORC60_4695 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FORC60_4696 ENOG4105C2M dna polymerase I FORC60_4697 ENOG4105BZU Histidine kinase FORC60_4698 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC60_4703 ENOG4108HMX isocitrate dehydrogenase (NADP) FORC60_4704 ENOG4105BZN citrate synthase FORC60_4706 ENOG4108REF Sporulation integral membrane protein ytvi FORC60_4707 ENOG4105FS0 cytoplasmic membrane protein FORC60_4712 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FORC60_4713 ENOG4105C6K Malic enzyme FORC60_4714 ENOG4105C0B DNA polymerase III (alpha subunit) FORC60_4715 ENOG4105VV2 FORC60_4717 ENOG4105SFS phosphoesterase RecJ domain protein FORC60_4723 ENOG4105DC7 peptidase M24 FORC60_4729 ENOG4105Z7P Acetyltransferase (GNAT) family FORC60_4730 ENOG41082W1 Cupin 2, conserved barrel domain protein FORC60_4734 ENOG4107YZX Universal stress protein FORC60_4743 ENOG4108JYZ YitT family FORC60_4747 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FORC60_4749 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FORC60_4750 ENOG4106F1P AAA ATPase, central domain protein FORC60_4752 ENOG4105KBJ sporulation protein ytfj FORC60_4755 ENOG4105EFZ amidohydrolase FORC60_4757 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FORC60_4762 ENOG4105RQF LysR family Transcriptional regulator FORC60_4764 ENOG4105U5Y Transcriptional regulator FORC60_4766 ENOG4105C28 cystathionine FORC60_4775 ENOG4108UW5 maltose o-acetyltransferase FORC60_4777 ENOG4105F1V Acetoin utilization protein FORC60_4778 ENOG4105W87 Cbs domain FORC60_4779 ENOG4105DGU Histone deacetylase FORC60_4782 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC60_4784 ENOG4107SNB ankyrin repeat protein YahD FORC60_4785 ENOG4105EP9 oxidoreductase FORC60_4791 ENOG4105ETE Transcriptional regulator (LacI family FORC60_4792 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FORC60_4796 ENOG4105C88 aminopeptidase FORC60_4803 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FORC60_4805 ENOG4108VDD TRNA binding domain protein FORC60_4811 ENOG4105C8F Beta-lactamase domain protein FORC60_4814 ENOG4108V15 phosphotransferase enzyme family FORC60_4815 ENOG4108IUM Glycogen debranching enzyme FORC60_4817 ENOG4107QSE Dipeptidase FORC60_4818 ENOG4105YW5 deoR family transcriptional regulator FORC60_4821 ENOG4105CBX hi0933 family FORC60_4828 ENOG4108VJ1 Transcriptional regulator (CarD family FORC60_4829 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FORC60_4830 ENOG4105CSC Glucose uptake protein FORC60_4833 ENOG4108ZAF Molybdopterin FORC60_4834 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FORC60_4835 ENOG4105CVM Molybdenum cofactor synthesis domain protein FORC60_4837 ENOG4105D06 uba thif-type nad fad binding protein FORC60_4838 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FORC60_4842 ENOG41085GJ domain protein FORC60_4844 ENOG4105DWV Homoserine O-trans-acetylase FORC60_4846 ENOG4108B31 Spore germination protein FORC60_4851 ENOG4105C8T Leucyl-tRNA synthetase FORC60_4852 ENOG410605W Major Facilitator FORC60_4853 ENOG4107S91 Sodium hydrogen exchanger FORC60_4854 ENOG4105NCW Trka-c domain protein FORC60_4857 ENOG4105C19 ABC transporter FORC60_4861 ENOG4105N5T Radical SAM Protein FORC60_4866 ENOG4105E8V Alpha Beta Hydrolase Fold protein FORC60_4867 ENOG4108Z0R Transferase FORC60_4868 ENOG4105YVM Phosphoesterase, PA-phosphatase related FORC60_4869 ENOG4105BZF Glycosyl transferase (Group 1 FORC60_4871 ENOG4105EPU Molybdenum cofactor synthesis domain protein FORC60_4873 ENOG4108MK9 spermidine N(1)-acetyltransferase FORC60_4884 ENOG4105BZU Histidine kinase FORC60_4885 ENOG4105BZU Histidine kinase FORC60_4886 ENOG4105CH6 catalase FORC60_4888 ENOG4107S9D Alpha beta hydrolase FORC60_4889 ENOG4107T7U Sulfatase FORC60_4894 ENOG4105D2X ABC transporter substrate-binding protein FORC60_4896 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FORC60_4909 ENOG4108V2W Carbonate dehydratase FORC60_4910 ENOG4105C4M (Ubiquinol oxidase) subunit I FORC60_4911 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FORC60_4920 ENOG41087YS Phage shock protein A FORC60_4926 ENOG4105BZU Histidine kinase FORC60_4927 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC60_4933 ENOG4108UGV hypoxanthine phosphoribosyltransferase FORC60_4934 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FORC60_4943 ENOG4107ZTW SNARE associated Golgi FORC60_4946 ENOG4105C19 ABC transporter FORC60_4947 ENOG41086D8 Transcriptional regulator FORC60_4952 ENOG41082BM Transcriptional regulator, arsr family FORC60_4961 ENOG4105FDP GntR family transcriptional regulator FORC60_4965 ENOG41069H0 dihydroorotase EC 3.5.2.3 FORC60_4969 ENOG4105DTQ mandelate racemase muconate lactonizing FORC60_4970 ENOG4105CEY Amp-dependent synthetase and ligase FORC60_4972 ENOG4108IPT Naphthoate synthase FORC60_4973 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FORC60_4974 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FORC60_4975 ENOG4105E4F Isochorismate synthase FORC60_4976 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FORC60_4979 ENOG4105VEQ Cold shock protein FORC60_4987 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FORC60_4991 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FORC60_4992 ENOG4105KT7 mgtC SapB transporter FORC60_4993 ENOG4107PBV potassium channel FORC60_4996 ENOG4105WG9 Conserved Protein FORC60_4998 ENOG4105CHM Aminotransferase FORC60_4999 ENOG4108ZB6 transcriptional regulator AsnC family FORC60_5000 ENOG4105C5I Dehydrogenase FORC60_5001 ENOG4108MUZ hydrolase FORC60_5003 ENOG4105C87 Aminotransferase class I and II FORC60_5006 ENOG4105Y38 Kinase-associated protein B FORC60_5008 ENOG4107R3E Citrate transporter FORC60_5011 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FORC60_5012 ENOG4105KA0 thioesterase Superfamily protein FORC60_5015 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FORC60_5020 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) FORC60_5021 ENOG4106YN8 Prenyltransferase FORC60_5023 ENOG41069ER domain protein FORC60_5027 ENOG4105CEP NADH dehydrogenase FORC60_5033 ENOG4105EWC Purine nucleoside phosphorylase FORC60_5038 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FORC60_5043 ENOG4108JJA ABC, transporter FORC60_5044 ENOG4105C4B ABC transporter, permease FORC60_5045 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FORC60_5051 ENOG41083MR nifu domain-containing protein FORC60_5054 ENOG4108W5N phosphatidylglycerophosphatase a FORC60_5062 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FORC60_5063 ENOG4105DYS nad(p)h dehydrogenase (quinone) FORC60_5065 ENOG4105D4U had-superfamily hydrolase, subfamily iia FORC60_5068 ENOG4105CBT Fructose-1,6-bisphosphatase FORC60_5072 ENOG4105MMD transcriptional regulator FORC60_5073 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FORC60_5074 ENOG4107TXC Transcriptional regulator FORC60_5075 ENOG41090T1 Membrane FORC60_5080 ENOG4105FAA peptidase M23 FORC60_5081 ENOG4108YTE sporulation protein YunB FORC60_5082 ENOG4105KZD Domain of unknown function (DUF1805) FORC60_5083 ENOG4107R8B 5'-nucleotidase FORC60_5084 ENOG4105DIW FeS assembly protein SUFB FORC60_5085 ENOG4108UNV SUF system FeS assembly protein, NifU family FORC60_5086 ENOG4105C9B Cysteine desulfurase FORC60_5087 ENOG4105JRK feS assembly protein SufD FORC60_5088 ENOG4105C3K feS assembly ATPase SufC FORC60_5089 ENOG4105D01 (LipO)protein FORC60_5090 ENOG4105D01 (LipO)protein FORC60_5091 ENOG4108UMI ABC transporter, permease FORC60_5092 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FORC60_5098 ENOG41080E8 Transcriptional regulator, Spx MgsR family FORC60_5102 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FORC60_5110 ENOG4108W8B Beta-lactamase domain protein FORC60_5111 ENOG4105C1G acyl-Coa dehydrogenase FORC60_5114 ENOG4105CHU acetyl-coa acetyltransferase FORC60_5117 ENOG4105DZ1 carboxypeptidase FORC60_5121 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FORC60_5124 ENOG4108SUT Major Facilitator Superfamily FORC60_5125 ENOG4107R7I amino acid FORC60_5128 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FORC60_5130 ENOG4107AYK membrAne FORC60_5138 ENOG4107ZTW SNARE associated Golgi FORC60_5140 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FORC60_5141 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC60_5142 ENOG4105BZU Histidine kinase FORC60_5148 ENOG4105C8Q Methyl-accepting chemotaxis FORC60_5149 ENOG4105VG1 fes assembly suf system protein FORC60_5150 ENOG4105D4Y metalloprotease FORC60_5154 ENOG4107S91 Sodium hydrogen exchanger FORC60_5155 ENOG4105NCW Trka-c domain protein FORC60_5159 ENOG4108RMU ferritin dps family protein FORC60_5162 ENOG4108URH decarboxylase FORC60_5164 ENOG41090A1 ferritin FORC60_5166 ENOG4105D9N nucleoside FORC60_5167 ENOG4105D9N nucleoside FORC60_5170 ENOG4108RYK Nad-dependent epimerase dehydratase FORC60_5173 ENOG4105CV8 reductase FORC60_5174 ENOG4105F27 Major Facilitator FORC60_5175 ENOG4105KVH Transcriptional regulator FORC60_5178 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FORC60_5179 ENOG4105D4A Cell wall formation (By similarity) FORC60_5183 ENOG4105WMR Protein CrcB homolog FORC60_5184 ENOG4105WMR Protein CrcB homolog FORC60_5188 ENOG4105C5H ABC transporter FORC60_5189 ENOG4108MK9 spermidine N(1)-acetyltransferase FORC60_5190 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FORC60_5195 ENOG4108IPW abc transporter atp-binding protein FORC60_5196 ENOG4105CM4 permease protein FORC60_5199 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC60_5201 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FORC60_5203 ENOG4105XZU Preprotein translocase, subunit SecG FORC60_5204 ENOG41067MG lrgb family FORC60_5214 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC60_5215 ENOG4105RHA ABC transporter, permease FORC60_5216 ENOG4108IUX (ABC) transporter FORC60_5218 ENOG4105BZU Histidine kinase FORC60_5219 ENOG4108W5X Transcriptional Regulator, LuxR family FORC60_5222 ENOG41090VF Stage v sporulation protein ac FORC60_5223 ENOG4105CZ3 stage V sporulation protein ad FORC60_5226 ENOG4108QY0 Membrane FORC60_5227 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FORC60_5228 ENOG4105KRI phosphocarrier protein (HPr FORC60_5230 ENOG4105CHW UPF0052 protein FORC60_5231 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FORC60_5232 ENOG4108Z4K mutator MutT protein FORC60_5234 ENOG4105C3M thioredoxin reductase FORC60_5236 ENOG4108S4C acetyltransferase FORC60_5238 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) FORC60_5240 ENOG41086DT Membrane protein of unknown function FORC60_5242 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FORC60_5243 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FORC60_5246 ENOG4107TXC Transcriptional regulator FORC60_5251 ENOG4105HMI Membrane FORC60_5252 ENOG4105DUM transcriptional regulator, lysR family FORC60_5254 ENOG4108WS4 fmn reductase FORC60_5257 ENOG4105BZ1 (ABC) transporter FORC60_5259 ENOG4105CN1 protease FORC60_5260 ENOG4105CRP Part of the ABC transporter FtsEX involved in FORC60_5261 ENOG4105CAK Cell division ATP-binding protein ftsE FORC60_5267 ENOG4108RDQ ABC transporter FORC60_5274 ENOG4105MS2 ribosomal subunit Interface protein FORC60_5276 ENOG4105VEQ Cold shock protein FORC60_5277 ENOG41081UC Inherit from COG: Competence protein FORC60_5281 ENOG4105KVH Transcriptional regulator FORC60_5284 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FORC60_5285 ENOG4108KGH TRANSCRIPTIONal FORC60_5286 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FORC60_5287 ENOG4105C6Y Udp-glucose 6-dehydrogenase FORC60_5288 ENOG4105ESV Glycosyl transferase, family 4 FORC60_5290 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FORC60_5294 ENOG4105F8D glycoside hydrolase family 4 FORC60_5295 ENOG4105VCP PTS System FORC60_5296 ENOG4105CK1 PTS System FORC60_5298 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FORC60_5299 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FORC60_5300 ENOG4105VCP PTS System FORC60_5302 ENOG4105VZJ PTS System FORC60_5306 ENOG4105ECB domain protein FORC60_5307 ENOG4107RSM transcriptional regulator FORC60_5317 ENOG4105DAA L-lactate FORC60_5319 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FORC60_5321 ENOG4105E0M Sulfatase FORC60_5329 ENOG4107R8N Glycosyl transferase, family 2 FORC60_5331 ENOG4105C94 Transporter FORC60_5332 ENOG41069ER domain protein FORC60_5337 ENOG4105KBK Zinc finger, swim domain protein FORC60_5338 ENOG4105C0D helicase FORC60_5344 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC60_5346 ENOG4107RBB ABC transporter, permease FORC60_5347 ENOG4105C19 ABC transporter FORC60_5349 ENOG4105CXY transporter FORC60_5352 ENOG4105BZU Histidine kinase FORC60_5353 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC60_5354 ENOG4105CMR udp-glucose 4-epimerase FORC60_5356 ENOG4108KGH TRANSCRIPTIONal FORC60_5358 ENOG4107TAE Glycosyl transferase (Group 1 FORC60_5359 ENOG4105K64 Glycosyl transferase, family 2 FORC60_5365 ENOG4105D3Q Sugar transferase FORC60_5366 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FORC60_5367 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FORC60_5368 ENOG4107YJ4 chain length determinant protein FORC60_5369 ENOG4105HTX biosynthesis protein FORC60_5370 ENOG4107YJ4 chain length determinant protein FORC60_5373 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FORC60_5375 ENOG4105FRN stage II sporulation protein FORC60_5378 ENOG4105DY9 regulatoR FORC60_5382 ENOG4106778 Protein of unknown function (DUF1146) FORC60_5383 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FORC60_5384 ENOG4105C8S subunit m FORC60_5385 ENOG4105D65 subunit l FORC60_5390 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FORC60_5391 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FORC60_5394 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FORC60_5395 ENOG4105BZU Histidine kinase FORC60_5405 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FORC60_5406 ENOG41062M3 atp synthase FORC60_5410 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FORC60_5411 ENOG4108UIC UPF0340 protein FORC60_5412 ENOG4108YZG isomerase FORC60_5415 ENOG4108VGI doxx family FORC60_5416 ENOG4107XC4 flavin reductase domain protein, FMN-binding FORC60_5420 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FORC60_5422 ENOG4108ZXQ stage ii sporulation protein r FORC60_5423 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FORC60_5424 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FORC60_5425 ENOG4107104 thymidine kinase FORC60_5427 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FORC60_5428 ENOG4105CBT Fructose-1,6-bisphosphatase FORC60_5430 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FORC60_5434 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FORC60_5437 ENOG4105C1G acyl-Coa dehydrogenase FORC60_5438 ENOG4105C1G acyl-Coa dehydrogenase FORC60_5439 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FORC60_5441 ENOG4105DF6 Fe-S oxidoreductase FORC60_5444 ENOG4105BZU Histidine kinase FORC60_5447 ENOG4105D4Y metalloprotease FORC60_5449 ENOG4105BZU Histidine kinase FORC60_5450 ENOG4105KCT ABC transporter FORC60_5451 ENOG4108M15 ABC transporter FORC60_5452 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FORC60_5454 ENOG4105IIU Aminopeptidase FORC60_5455 ENOG4105DQ6 Transposase FORC60_5459 ENOG4105DU6 RNA polymerase FORC60_5461 ENOG410684U Domain of unknown function (DUF1934) FORC60_5466 ENOG4105CYW agmatinase FORC60_5468 ENOG4105DXB Major Facilitator superfamily FORC60_5469 ENOG4107SWG transcriptional regulator MERR family FORC60_5471 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FORC60_5472 ENOG4105BZ4 penicillin-binding protein FORC60_5473 ENOG4108XFG YwhD family FORC60_5474 ENOG4108Z4T Peptidase M50 FORC60_5475 ENOG41069HH 4-oxalocrotonate tautomerase FORC60_5476 ENOG4105DCI Phosphohydrolase FORC60_5477 ENOG4108MES Periplasmic binding protein FORC60_5478 ENOG4105E0A ABC, transporter FORC60_5479 ENOG4105EHG Permease protein FORC60_5480 ENOG4105DQ5 transport system permease protein FORC60_5482 ENOG4108VCI transcription factor, rsfa family FORC60_5483 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) FORC60_5484 ENOG4108IJ2 phosphate acetyltransferase FORC60_5485 ENOG4107UEZ chlorite dismutase FORC60_5487 ENOG4108VKI Cell wall hydrolase FORC60_5491 ENOG4107SVH Potassium channel protein FORC60_5493 ENOG410667J hydrolase FORC60_5494 ENOG4105VCH membrane FORC60_5496 ENOG4108TU7 Inherit from COG: (ABC) transporter FORC60_5497 ENOG4105CJ1 ABC, transporter FORC60_5498 ENOG41090WU lipolytic protein G-D-S-L family FORC60_5501 ENOG4105D6E homoserine dehydrogenase FORC60_5506 ENOG4108Y4K DNA-binding transcriptional activator FORC60_5508 ENOG4105WH1 Two component transcriptional regulator luxr family FORC60_5509 ENOG4105WH1 Two component transcriptional regulator luxr family FORC60_5510 ENOG4105BZU Histidine kinase FORC60_5511 ENOG4105DWF phosphomethylpyrimidine kinase FORC60_5512 ENOG4105BZU Histidine kinase FORC60_5513 ENOG4105VCD cytoplasmic protein FORC60_5514 ENOG4105D22 carbon starvation protein FORC60_5515 ENOG4105DY9 regulatoR FORC60_5517 ENOG41079KZ Major Facilitator Superfamily FORC60_5519 ENOG4105CG5 Glycosyl transferase (Group 1 FORC60_5521 ENOG4105EN6 Membrane FORC60_5522 ENOG4106YBV Methyl-accepting chemotaxis FORC60_5524 ENOG4108S4H thioesterase Superfamily protein FORC60_5526 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) FORC60_5528 ENOG4105K64 Glycosyl transferase, family 2 FORC60_5531 ENOG4105EJV Membrane FORC60_5532 ENOG4105CKK Glycosyl transferase, family 2 FORC60_5533 ENOG4105C5H ABC transporter FORC60_5534 ENOG41067SE Tetr family transcriptional regulator FORC60_5536 ENOG4105E0X reductase FORC60_5537 ENOG4106F5Q Membrane FORC60_5540 ENOG4108NEV two component transcriptional regulator, LytTR family FORC60_5541 ENOG4108HRK Histidine kinase FORC60_5542 ENOG4107RGD Major Facilitator superfamily FORC60_5545 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FORC60_5547 ENOG4105IW1 AmiS UreI transporter FORC60_5548 ENOG4105CMR udp-glucose 4-epimerase FORC60_5549 ENOG4108UT2 hemolysin iii FORC60_5551 ENOG4105C1J atp-dependent rna helicase FORC60_5552 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) FORC60_5553 ENOG4105DPN Oligoendopeptidase f FORC60_5555 ENOG4105BZU Histidine kinase FORC60_5556 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) FORC60_5558 ENOG4105C0H protease FORC60_5559 ENOG4105Q2H domain protein FORC60_5562 ENOG4105BZU Histidine kinase FORC60_5563 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC60_5564 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FORC60_5565 ENOG4105CDU Replicative dna helicase FORC60_5567 ENOG4105BZR domain protein FORC60_5568 ENOG4105BZR domain protein FORC60_5571 ENOG4108UUM single-stranded DNA-binding protein FORC60_5573 ENOG4105C3G gtp-binding protein FORC60_5574 ENOG4105VDK protein, conserved in bacteria FORC60_5575 ENOG4105D8X mechanosensitive ion channel FORC60_5576 ENOG4108ZDA Sporulation protein YyaC FORC60_5577 ENOG4105FA0 parb-like partition protein FORC60_5578 ENOG4107QJE Chromosome Partitioning Protein FORC60_5581 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FORC60_5582 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FORC60_5584 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FORC60_t098 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation