locus-tag class description FORC5_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FORC5_0003 ENOG410848D S4 domain protein YaaA FORC5_0006 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FORC5_0008 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FORC5_0014 ENOG4105ZMH deoxynucleoside kinase FORC5_0016 ENOG4105GTG Isochorismatase FORC5_0017 ENOG4108Z6B deaminase FORC5_0018 ENOG4105C6E dna polymerase iii FORC5_0022 ENOG41067KS pro-sigma K processing FORC5_0024 ENOG4105CXN decarboxylase FORC5_0026 ENOG4105FA2 dna polymerase iii FORC5_0027 ENOG4105MA4 psp1 domain protein FORC5_0029 ENOG41060K3 Methyltransferase FORC5_0031 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FORC5_0032 ENOG4105KRN Transcriptional regulator, abrb family FORC5_0033 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FORC5_0034 ENOG4105F8V Hydrolase, tatD family FORC5_0035 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FORC5_0037 ENOG4105XFA sporulation peptidase YabG FORC5_0038 ENOG4105W42 Veg protein FORC5_0041 ENOG4105DFT pur operon repressor FORC5_0042 ENOG4105KME endoribonuclease L-psp FORC5_0045 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FORC5_0046 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FORC5_0048 ENOG4108JA2 transcriptioN-repair coupling factor FORC5_0049 ENOG4108M14 stage v sporulation protein t FORC5_0051 ENOG4108IY2 MazG family FORC5_0052 ENOG41082I2 s4 domain protein FORC5_0053 ENOG4105VYY sporulation protein yabp FORC5_0056 ENOG41060GV RNA binding s1 domain protein FORC5_0058 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FORC5_0059 ENOG4108UGV hypoxanthine phosphoribosyltransferase FORC5_0060 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FORC5_0063 ENOG4105C6T cysteine synthase FORC5_0064 ENOG4105CRQ synthase (Component I) FORC5_0065 ENOG4105DDQ anthranilate synthase FORC5_0066 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FORC5_0067 ENOG4105EEI dihydropteroate synthase FORC5_0068 ENOG4105KRF dihydroneopterin aldolase FORC5_0069 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FORC5_0071 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FORC5_0075 ENOG4108Z0C Uvrb UvrC protein FORC5_0078 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FORC5_0080 ENOG4105CTP PilT protein domain protein FORC5_0081 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FORC5_0084 ENOG4105D7W serine acetyltransferase FORC5_0087 ENOG4105C2N RNA methyltransferase TrmH family group 3 FORC5_0088 ENOG4105M0M Tetracycline resistance protein FORC5_0089 ENOG4105QIV RNA polymerase FORC5_0091 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FORC5_0096 ENOG4107Y49 methyltransferase FORC5_0099 ENOG4105XPM ribosomal protein FORC5_0120 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FORC5_0125 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FORC5_0127 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FORC5_0133 ENOG4108JJB ABC transporter FORC5_0134 ENOG4108JJB ABC transporter FORC5_0135 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FORC5_0136 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FORC5_0141 ENOG4105D1F ATP-binding protein FORC5_0144 ENOG4108NMV polysaccharide deacetylase FORC5_0148 ENOG4105C8B TIGR00159 family FORC5_0149 ENOG4107U5W ybbr family FORC5_0152 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FORC5_0159 ENOG4108PSK reductase FORC5_0160 ENOG4108UMI ABC transporter, permease FORC5_0161 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FORC5_0162 ENOG4105D01 (LipO)protein FORC5_0163 ENOG4105CB2 alcohol dehydrogenase FORC5_0165 ENOG4105IQ5 FAD linked oxidase domain protein FORC5_0168 ENOG4105C2C drug resistance transporter, Bcr CflA FORC5_0171 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FORC5_0172 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC5_0173 ENOG4105C3U ABC transporter FORC5_0174 ENOG4108JQ7 (ABC) transporter FORC5_0180 ENOG4108J59 Extracellular solute-binding protein, family 5 FORC5_0181 ENOG4108J59 Extracellular solute-binding protein, family 5 FORC5_0185 ENOG4105E0C molybdate abc transporter FORC5_0186 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FORC5_0187 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FORC5_0188 ENOG4105EGI Transcriptional regulator FORC5_0190 ENOG4105F6E Acyl-transferase FORC5_0193 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FORC5_0196 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FORC5_0199 ENOG4105C5H ABC transporter FORC5_0201 ENOG4105DEF Extracellular solute-binding protein, family 5 FORC5_0203 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC5_0204 ENOG4105C3U ABC transporter FORC5_0205 ENOG4108JQ7 (ABC) transporter FORC5_0206 ENOG410667J hydrolase FORC5_0208 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FORC5_0209 ENOG4105ERH Fumarylacetoacetate hydrolase FORC5_0211 ENOG4105CUB amino acid FORC5_0212 ENOG4108SC4 )-transporter FORC5_0213 ENOG4105CPF Cell wall formation (By similarity) FORC5_0214 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FORC5_0219 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FORC5_0220 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FORC5_0222 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FORC5_0225 ENOG4105K8N protein family UPF0079, ATPase FORC5_0226 ENOG41072GX Peptidase M22 Glycoprotease FORC5_0227 ENOG410801F ribosomal-protein-alanine acetyltransferase FORC5_0228 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FORC5_0229 ENOG4105C5H ABC transporter FORC5_0232 ENOG4108TYN CAAX amino terminal protease family protein FORC5_0236 ENOG4105C7N Xanthine uracil vitamin C permease FORC5_0238 ENOG4105BZU Histidine kinase FORC5_0240 ENOG4107ZXU DSBA oxidoreductase FORC5_0246 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC5_0251 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) FORC5_0254 ENOG4105SX7 Transporter FORC5_0257 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FORC5_0258 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FORC5_0259 ENOG4105C83 adenylosuccinate lyase FORC5_0261 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FORC5_0266 ENOG4108V3E phosphoribosylglycinamide formyltransferase FORC5_0267 ENOG4105DC1 bifunctional purine biosynthesis protein purh FORC5_0268 ENOG4105C12 Phosphoribosylglycinamide synthetase FORC5_0273 ENOG4105C4R Atp-dependent dna helicase FORC5_0278 ENOG4108W2Y isochorismatase FORC5_0279 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FORC5_0280 ENOG4108UMI ABC transporter, permease FORC5_0281 ENOG4105D01 (LipO)protein FORC5_0285 ENOG410834F Transcriptional regulator FORC5_0286 ENOG4107I77 yiaA/B two helix domain FORC5_0290 ENOG4105CBD Diacylglycerol kinase FORC5_0292 ENOG4108JPW Aminotransferase FORC5_0294 ENOG4105C26 Dehydrogenase FORC5_0295 ENOG4105KPY Small multidrug resistance protein FORC5_0301 ENOG4105D9N nucleoside FORC5_0302 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FORC5_0304 ENOG4108W15 Protein of unknown function (DUF1456) FORC5_0307 ENOG4105DTQ mandelate racemase muconate lactonizing FORC5_0309 ENOG4105DFD Na H antiporter FORC5_0313 ENOG4105D3R alkyl hydroperoxide reductase FORC5_0314 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FORC5_0315 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FORC5_0316 ENOG4107W7X Aldolase FORC5_0317 ENOG4105EHG Permease protein FORC5_0318 ENOG4105DQ5 transport system permease protein FORC5_0319 ENOG4108V5C ABC transporter FORC5_0320 ENOG4105CAY ferredoxin--nadp reductase FORC5_0324 ENOG4106UIA FORC5_0325 ENOG4106UIA FORC5_0328 ENOG4105BZU Histidine kinase FORC5_0332 ENOG410756H nucleotidyltransferase FORC5_0333 ENOG4105D2S major facilitator superfamily FORC5_0336 ENOG4105E5Q amino acid AbC transporter FORC5_0337 ENOG4105EAB amino acid AbC transporter FORC5_0339 ENOG4105C8Q Methyl-accepting chemotaxis FORC5_0342 ENOG4105DBV ornithine carbamoyltransferase FORC5_0344 ENOG4105C5B carbamate kinase FORC5_0345 ENOG4108W63 CRP FNR family transcriptional regulator FORC5_0347 ENOG4105DNP FAD linked oxidase domain protein FORC5_0349 ENOG4105CI1 PTS System FORC5_0352 ENOG4105C9U ATP-dependent DNA helicase RecQ FORC5_0355 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FORC5_0359 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FORC5_0360 ENOG4105D2X ABC transporter substrate-binding protein FORC5_0366 ENOG41062JF Transcriptional regulator FORC5_0369 ENOG4105DEU major facilitator superfamily FORC5_0372 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FORC5_0375 ENOG4108N0M stress protein FORC5_0376 ENOG4106FN3 tellurium resistance protein FORC5_0377 ENOG4106FN3 tellurium resistance protein FORC5_0378 ENOG4107TS3 membrane protein, TerC FORC5_0379 ENOG4108TTB tellurium resistance protein FORC5_0382 ENOG41068PA UPF0435 protein FORC5_0383 ENOG4105KJF protein tyrosine phosphatase FORC5_0385 ENOG4107U9T Pfam:Ribonuclease_BN FORC5_0386 ENOG4105C59 p-type ATPase FORC5_0387 ENOG4108IPJ Membrane FORC5_0391 ENOG4107ZTW SNARE associated Golgi FORC5_0393 ENOG410606W general stress protein FORC5_0394 ENOG4105UPD Calcium Proton FORC5_0401 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FORC5_0402 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FORC5_0404 ENOG4108JUB Transcriptional regulator FORC5_0406 ENOG4108IQI permease FORC5_0414 ENOG4108A04 Beta-lactamase FORC5_0417 ENOG4105CKK Glycosyl transferase, family 2 FORC5_0418 ENOG4107QQG Dehydrogenase FORC5_0419 ENOG4105C3I Nad-dependent epimerase dehydratase FORC5_0423 ENOG4105F1A Pyruvate formate-lyase FORC5_0426 ENOG4105CI2 imidazolone-5-propionate hydrolase FORC5_0427 ENOG4105ECP epimerase FORC5_0433 ENOG41067AE Membrane-bound metal-dependent hydrolase FORC5_0434 ENOG4105CEN a g-specific adenine glycosylase FORC5_0435 ENOG4106BXE FORC5_0439 ENOG4105BZ1 (ABC) transporter FORC5_0440 ENOG4107NBY Membrane FORC5_0441 ENOG4105CBC glutamate synthase FORC5_0443 ENOG4108IUW ABC transporter FORC5_0447 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC5_0448 ENOG4105G5W regulator Fur family FORC5_0452 ENOG4105CDY transcriptional regulatory protein FORC5_0454 ENOG4108JQC penicillin-binding protein 1A FORC5_0455 ENOG4108R9S DSBA oxidoreductase FORC5_0456 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FORC5_0458 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FORC5_0459 ENOG4105BZU Histidine kinase FORC5_0460 ENOG4105CYN Serine protein kinase FORC5_0464 ENOG4105C94 Transporter FORC5_0467 ENOG4105DZ6 Band 7 protein FORC5_0469 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FORC5_0470 ENOG4108V9W transcriptional regulatory protein FORC5_0471 ENOG4105D4T Citrate transporter FORC5_0475 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FORC5_0476 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC5_0477 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FORC5_0478 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FORC5_0479 ENOG4105BZ7 extracellular solute-binding protein family 1 FORC5_0480 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FORC5_0481 ENOG4108STX response regulator FORC5_0482 ENOG4105US7 Histidine kinase FORC5_0487 ENOG4108MRH transcriptional regulatory protein FORC5_0489 ENOG4105C6K Malic enzyme FORC5_0491 ENOG4108UZ3 Transporter FORC5_0492 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC5_0494 ENOG4105BZU Histidine kinase FORC5_0496 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FORC5_0497 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FORC5_0498 ENOG4108JB9 formate dehydrogenase FORC5_0502 ENOG4105CUB amino acid FORC5_0505 ENOG4105C59 p-type ATPase FORC5_0506 ENOG4105DAP Nicotinate phosphoribosyltransferase FORC5_0512 ENOG41073R8 VanW family FORC5_0513 ENOG4108KGH TRANSCRIPTIONal FORC5_0514 ENOG4105D9N nucleoside FORC5_0515 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FORC5_0516 ENOG4105C37 (CBS) domain FORC5_0517 ENOG4108IJ0 Aspartate ammonia-lyase FORC5_0518 ENOG4105DAA L-lactate FORC5_0521 ENOG4105DUX Transporter FORC5_0522 ENOG4108MES Periplasmic binding protein FORC5_0523 ENOG4105DQ5 transport system permease protein FORC5_0524 ENOG4108IHU transport system permease protein FORC5_0525 ENOG4105E0A ABC, transporter FORC5_0526 ENOG4105DMQ Methyltransferase FORC5_0527 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FORC5_0528 ENOG4105EXW epimerase dehydratase FORC5_0530 ENOG4107T89 von Willebrand factor, type A FORC5_0531 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FORC5_0532 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FORC5_0534 ENOG4105BZU Histidine kinase FORC5_0535 ENOG4105D5Q Arginine ornithine antiporter FORC5_0536 ENOG4107414 GntR family transcriptional regulator FORC5_0537 ENOG4105C5Y PTS System FORC5_0538 ENOG4105CG3 alpha amylase, catalytic region FORC5_0541 ENOG4105E1K spore germination protein FORC5_0542 ENOG4105CRN Aminoglycoside phosphotransferase FORC5_0543 ENOG4105BZG amino acid carrier protein FORC5_0544 ENOG4105CDA abc transporter atp-binding protein FORC5_0545 ENOG4105CT1 (ABC) transporter FORC5_0546 ENOG4105EAD ABC transporter FORC5_0547 ENOG4105DRP amino acid AbC transporter FORC5_0548 ENOG4108IQI permease FORC5_0551 ENOG4105D29 Helix-turn-helix type 11 domain protein FORC5_0552 ENOG4105NAE bifunctional deaminase-reductase domain protein FORC5_0553 ENOG4105BZU Histidine kinase FORC5_0558 ENOG4105CHH sulfate transporter FORC5_0559 ENOG41068KF Universal stress protein FORC5_0560 ENOG4105CXY transporter FORC5_0561 ENOG41067TZ transcriptional regulator, MarR family FORC5_0562 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC5_0563 ENOG4105ETE Transcriptional regulator (LacI family FORC5_0564 ENOG4108RVA ribokinase FORC5_0566 ENOG4105C2J ABC transporter FORC5_0567 ENOG4105CNN ABC, transporter FORC5_0568 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FORC5_0569 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FORC5_0575 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) FORC5_0581 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FORC5_0582 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FORC5_0583 ENOG41069ER domain protein FORC5_0584 ENOG4105VZ8 Transcriptional regulator FORC5_0585 ENOG4107D63 FORC5_0588 ENOG4105DUX Transporter FORC5_0592 ENOG4105C85 amino acid FORC5_0593 ENOG4105C7N Xanthine uracil vitamin C permease FORC5_0595 ENOG4105D7V transposase FORC5_0598 ENOG4105MA6 gCN5-related N-acetyltransferase FORC5_0602 ENOG4105CCU oxidase (Subunit III) FORC5_0603 ENOG4105BZ9 Cytochrome C oxidase, subunit I FORC5_0604 ENOG4105E2S oxidase) subunit II FORC5_0608 ENOG4106CAD Protein of unknown function (DUF3311) FORC5_0609 ENOG4105E1V na solute symporter FORC5_0612 ENOG4108NHD germination protein FORC5_0613 ENOG4105CE1 Ferrous iron transport protein b FORC5_0614 ENOG4105CE1 Ferrous iron transport protein b FORC5_0615 ENOG4105CE1 Ferrous iron transport protein b FORC5_0616 ENOG4105CVA phosphate FORC5_0617 ENOG4105C8U phosphate abc transporter FORC5_0618 ENOG4105E2Z phosphate ABC transporter (Permease FORC5_0620 ENOG41080XQ Signal transduction protein with cbs domains FORC5_0624 ENOG4105ETU transcriptional activator (TenA FORC5_0626 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FORC5_0628 ENOG4108VEU Thiamine monophosphate synthase FORC5_0629 ENOG41080HI glycine oxidase FORC5_0632 ENOG4105D06 uba thif-type nad fad binding protein FORC5_0633 ENOG4105DWF phosphomethylpyrimidine kinase FORC5_0641 ENOG4108INS Transcriptional regulator FORC5_0643 ENOG4105C7N Xanthine uracil vitamin C permease FORC5_0645 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FORC5_0649 ENOG4105C5Y PTS System FORC5_0652 ENOG4105K63 Thioredoxin FORC5_0656 ENOG4108B31 Spore germination protein FORC5_0660 ENOG4107Y03 Nitroreductase FORC5_0661 ENOG4105ED1 spovr family FORC5_0663 ENOG4108TCS Glutamyl endopeptidase FORC5_0668 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FORC5_0669 ENOG4105XTG Pfam:DUF156 FORC5_0670 ENOG4105VFE sira family FORC5_0671 ENOG4107TPS domain protein FORC5_0672 ENOG4105VFE sira family FORC5_0673 ENOG4105VFE sira family FORC5_0674 ENOG41085GJ domain protein FORC5_0675 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FORC5_0676 ENOG41087NI Sulfite exporter TauE/SafE FORC5_0678 ENOG4108KGH TRANSCRIPTIONal FORC5_0683 ENOG4105EMD TRANSCRIPTIONal FORC5_0684 ENOG4105VCP PTS System FORC5_0685 ENOG4105VZJ PTS System FORC5_0690 ENOG41069ER domain protein FORC5_0691 ENOG4107RBB ABC transporter, permease FORC5_0692 ENOG4105C19 ABC transporter FORC5_0698 ENOG4105WEF catalase FORC5_0705 ENOG4107T5V SNARE associated Golgi FORC5_0713 ENOG4105CUB amino acid FORC5_0714 ENOG4107RWR Sodium hydrogen exchanger FORC5_0716 ENOG4106KNT transcriptional regulator FORC5_0724 ENOG4108YXU transcriptional regulator AsnC family FORC5_0725 ENOG4105CH7 arginosuccinase FORC5_0726 ENOG4105UBK short-chain dehydrogenase reductase FORC5_0728 ENOG4105KPY Small multidrug resistance protein FORC5_0735 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FORC5_0736 ENOG4105E5W Transporter FORC5_0738 ENOG4107RKG DJ-1/PfpI family FORC5_0739 ENOG4105CH6 catalase FORC5_0741 ENOG4105D5Q Arginine ornithine antiporter FORC5_0742 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FORC5_0744 ENOG4105C26 Dehydrogenase FORC5_0745 ENOG4105BZ1 (ABC) transporter FORC5_0746 ENOG4105BZ1 (ABC) transporter FORC5_0748 ENOG4105DRP amino acid AbC transporter FORC5_0749 ENOG4105CDA abc transporter atp-binding protein FORC5_0752 ENOG410839P FORC5_0760 ENOG4107FQX Alpha-acetolactate decarboxylase FORC5_0764 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FORC5_0765 ENOG4105D4P Coproporphyrinogen iii oxidase FORC5_0769 ENOG4105CHH sulfate transporter FORC5_0774 ENOG4105CGU Enoyl-CoA hydratase FORC5_0778 ENOG4105DER m42 family FORC5_0781 ENOG4105CTU Proline racemase FORC5_0782 ENOG4105CIF Ornithine Cyclodeaminase FORC5_0785 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC5_0787 ENOG4108JQ7 (ABC) transporter FORC5_0792 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FORC5_0799 ENOG4108IBT Inherit from COG: transposase FORC5_0801 ENOG4105CSH Transporter FORC5_0803 ENOG4108MRH transcriptional regulatory protein FORC5_0811 ENOG4105CVR type I restriction-modification system FORC5_0818 ENOG4105CDU Replicative dna helicase FORC5_0823 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC5_0825 ENOG4105D9U N-acetyltransferase FORC5_0827 ENOG4105F6J Alpha beta hydrolase fold FORC5_0835 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FORC5_0838 ENOG4105CMT Dihydroxyacetone kinase FORC5_0840 ENOG4105CMT Dihydroxyacetone kinase FORC5_0847 ENOG41069ER domain protein FORC5_0853 ENOG4108WC5 Alpha Beta Hydrolase Fold protein FORC5_0861 ENOG4105WN5 stage II sporulation protein FORC5_0863 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC5_0865 ENOG4108MJI response regulator FORC5_0866 ENOG4105BZU Histidine kinase FORC5_0867 ENOG4105BZU Histidine kinase FORC5_0871 ENOG4105K8R UPF0145 protein FORC5_0874 ENOG4107QHE Choloylglycine hydrolase FORC5_0877 ENOG4107VRP DNA repair exonuclease FORC5_0878 ENOG4106D4I domain protein FORC5_0882 ENOG4107JM4 Tetratricopeptide repeat FORC5_0884 ENOG4108MUZ hydrolase FORC5_0889 ENOG4105F0F Oxalate decarboxylase FORC5_0891 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FORC5_0894 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FORC5_0898 ENOG4105DU6 RNA polymerase FORC5_0901 ENOG4105EEM helicase FORC5_0903 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC5_0908 ENOG4105K59 histidine triad (HIT) protein FORC5_0914 ENOG410905X membrane-flanked domain protein FORC5_0915 ENOG4105CKV Membrane FORC5_0923 ENOG410905X membrane-flanked domain protein FORC5_0924 ENOG4105CKV Membrane FORC5_0925 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FORC5_0926 ENOG4105BZ4 penicillin-binding protein FORC5_0928 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FORC5_0929 ENOG4105C1Q protoporphyrinogen oxidase FORC5_0934 ENOG4105NA0 Transcriptional regulator FORC5_0937 ENOG4105ECB domain protein FORC5_0943 ENOG4108MK9 spermidine N(1)-acetyltransferase FORC5_0945 ENOG4108RQ5 Beta-lactamase domain-containing protein FORC5_0946 ENOG4105DF9 Lipoate-protein, ligase FORC5_0948 ENOG4105CEY Amp-dependent synthetase and ligase FORC5_0950 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FORC5_0951 ENOG4108I5D sulfate abc transporter FORC5_0952 ENOG4105ECW sulfate abc transporter FORC5_0953 ENOG4108IJ6 ABC transporter FORC5_0979 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) FORC5_0981 ENOG4105ENX hydrolase FORC5_0982 ENOG4107RN3 metallophosphoesterase FORC5_0983 ENOG4107TVP HD domain protein FORC5_0985 ENOG4108AEY RNA polymerase sigma factor FORC5_0986 ENOG41086D8 Transcriptional regulator FORC5_0989 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC5_0993 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FORC5_0994 ENOG4105C8Q Methyl-accepting chemotaxis FORC5_0995 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) FORC5_0997 ENOG4107QP3 malate synthase g FORC5_1001 ENOG4105VEQ Cold shock protein FORC5_1008 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FORC5_1017 ENOG4105ERH Fumarylacetoacetate hydrolase FORC5_1019 ENOG4105C8Y Acetylornithine aminotransferase FORC5_1020 ENOG4106BKT UPF0344 protein FORC5_1022 ENOG4105CAQ asparagine synthetase FORC5_1023 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FORC5_1024 ENOG4105CH6 catalase FORC5_1025 ENOG4105BZU Histidine kinase FORC5_1028 ENOG4108VPT UPF0234 protein FORC5_1029 ENOG4105QNR S1 RNA binding domain protein FORC5_1030 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC5_1031 ENOG4107AYK membrAne FORC5_1032 ENOG41073B9 FORC5_1033 ENOG4108KP7 hydrolase FORC5_1035 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FORC5_1040 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FORC5_1041 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FORC5_1044 ENOG4105C31 Tryptophanyl-tRNA synthetase FORC5_1047 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FORC5_1048 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC5_1050 ENOG4108JQ7 (ABC) transporter FORC5_1051 ENOG4105UQX Mate efflux family protein FORC5_1055 ENOG4108ZCF integral membrane protein FORC5_1057 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FORC5_1059 ENOG4105DPN Oligoendopeptidase f FORC5_1062 ENOG4108Z18 K06886 hemoglobin FORC5_1063 ENOG4105MIX Adenylate cyclase FORC5_1064 ENOG4106EFP UPF0738 protein FORC5_1066 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FORC5_1067 ENOG4105EMS pseudouridine synthase FORC5_1071 ENOG4105K64 Glycosyl transferase, family 2 FORC5_1076 ENOG4107TVC Glycosyl transferase, family 2 FORC5_1080 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FORC5_1081 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FORC5_1083 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FORC5_1093 ENOG4108ZMI UPF0477 protein FORC5_1097 ENOG4105CK7 Sodium proline symporter FORC5_1098 ENOG4105CRQ synthase (Component I) FORC5_1099 ENOG4105DDQ anthranilate synthase FORC5_1103 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FORC5_1117 ENOG4105C7S Dehydrogenase FORC5_1118 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FORC5_1119 ENOG4105VZ8 Transcriptional regulator FORC5_1142 ENOG4108NE4 FORC5_1148 ENOG4105C79 DNA protecting protein DprA FORC5_1150 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FORC5_1155 ENOG4105DZ1 carboxypeptidase FORC5_1156 ENOG4105VFR signal peptidase FORC5_1162 ENOG4105C26 Dehydrogenase FORC5_1163 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC5_1164 ENOG4105F38 ABC transporter, permease FORC5_1165 ENOG4105D38 putrescine abc transporter FORC5_1166 ENOG4107RUE extracellular solute-binding protein family 1 FORC5_1168 ENOG4105EYF MMPL domain protein FORC5_1170 ENOG4108YBP pseudouridine synthase FORC5_1172 ENOG4105K4I Scp-like extracellular FORC5_1173 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FORC5_1174 ENOG4105CQB FAD linked oxidase domain protein FORC5_1177 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC5_1178 ENOG4105BZU Histidine kinase FORC5_1179 ENOG4105JXH GntR family transcriptional regulator FORC5_1183 ENOG4106A3R peptidase FORC5_1185 ENOG4108QTI )-transporter FORC5_1186 ENOG4107TS3 membrane protein, TerC FORC5_1187 ENOG4105CZN Potassium uptake protein FORC5_1188 ENOG410681C small acid-soluble spore protein FORC5_1189 ENOG4108Z7G MaoC domain protein dehydratase FORC5_1193 ENOG4105CHR reductase FORC5_1199 ENOG4105C4Y ABC transporter FORC5_1200 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC5_1201 ENOG4107RCV ABC transporter, permease FORC5_1205 ENOG4105E98 transcriptional regulator DeoR family FORC5_1207 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FORC5_1209 ENOG4105PXI polysaccharide deacetylase FORC5_1211 ENOG4105BZU Histidine kinase FORC5_1212 ENOG41090MY MarR family Transcriptional regulator FORC5_1214 ENOG4106DF1 FORC5_1215 ENOG4105BZU Histidine kinase FORC5_1216 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FORC5_1217 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FORC5_1218 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FORC5_1226 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FORC5_1227 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FORC5_1228 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FORC5_1229 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FORC5_1230 ENOG4105CZV ABC transporter FORC5_1232 ENOG4105CJ1 ABC, transporter FORC5_1240 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FORC5_1241 ENOG4105EA8 2-Nitropropane dioxygenase FORC5_1242 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FORC5_1244 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FORC5_1248 ENOG4105NQC Flavodoxin FORC5_1255 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FORC5_1261 ENOG4105CZN Potassium uptake protein FORC5_1262 ENOG41063Y9 FORC5_1263 ENOG4105KBJ sporulation protein ytfj FORC5_1267 ENOG4105CM2 brancheD-chain amino acid aminotransferase FORC5_1268 ENOG4105C7K acetolactate synthase FORC5_1269 ENOG4108ZP8 Acetolactate synthase small subunit FORC5_1270 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FORC5_1273 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FORC5_1277 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FORC5_1278 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FORC5_1283 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase FORC5_1284 ENOG4107RVV histidinol phosphate phosphatase, hisj family FORC5_1287 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FORC5_1288 ENOG4105E0M Sulfatase FORC5_1290 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FORC5_1292 ENOG4107S4M Sulfate adenylate transferase FORC5_1293 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FORC5_1294 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FORC5_1296 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FORC5_1297 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FORC5_1298 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FORC5_1299 ENOG4105C8J )-transporter FORC5_1304 ENOG4105DFD Na H antiporter FORC5_1308 ENOG4105ENE Histidine kinase FORC5_1309 ENOG4105WH1 Two component transcriptional regulator luxr family FORC5_1313 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FORC5_1318 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FORC5_1322 ENOG4105CJ3 phosphate transporter FORC5_1323 ENOG4107GRR phosphate transport regulator FORC5_1324 ENOG4105BZ4 penicillin-binding protein FORC5_1327 ENOG4105BZU Histidine kinase FORC5_1328 ENOG4105I3N Conserved Protein FORC5_1331 ENOG4105BZU Histidine kinase FORC5_1337 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FORC5_1338 ENOG4105DZ1 carboxypeptidase FORC5_1339 ENOG4108JIC nucleoside recognition domain protein FORC5_1341 ENOG4105FE9 pseudouridine synthase FORC5_1342 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC5_1343 ENOG4107TWT Cytochrome c biogenesis protein FORC5_1344 ENOG4105CRE cytochrome C FORC5_1345 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC5_1346 ENOG4105BZU Histidine kinase FORC5_1347 ENOG4108WBT adenosyltransferase FORC5_1350 ENOG4108SAX Membrane FORC5_1353 ENOG4105C9U ATP-dependent DNA helicase RecQ FORC5_1354 ENOG4105I7S Abortive infection protein FORC5_1356 ENOG4107RGJ metallophosphoesterase FORC5_1357 ENOG4108XDN Transcriptional regulator FORC5_1358 ENOG4108S6Z Negative regulator of genetic competence FORC5_1363 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FORC5_1364 ENOG4107RB3 L-asparaginase FORC5_1368 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FORC5_1370 ENOG4105S2F FORC5_1371 ENOG41065D1 FORC5_1377 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FORC5_1380 ENOG4105XXQ heptaprenyl diphosphate synthase component I FORC5_1382 ENOG4105EAH synthase FORC5_1383 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FORC5_1384 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FORC5_1387 ENOG41068YB TPR repeat-containing protein FORC5_1390 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FORC5_1391 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FORC5_1398 ENOG4108JYZ YitT family FORC5_1399 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FORC5_1400 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FORC5_1402 ENOG4105FJR Lmbe family FORC5_1403 ENOG4105CPK Glycosyl transferase (Group 1 FORC5_1407 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FORC5_1410 ENOG4105DVT helicase FORC5_1411 ENOG4105YAC FORC5_1415 ENOG4105CSM endonuclease III FORC5_1417 ENOG4105BZ4 penicillin-binding protein FORC5_1428 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FORC5_1435 ENOG4105DVT helicase FORC5_1436 ENOG4105CTD carboxy-peptidase FORC5_1438 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FORC5_1439 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) FORC5_1440 ENOG4105C2W permease FORC5_1441 ENOG4105DHF Membrane FORC5_1443 ENOG410890F Dynamin family FORC5_1445 ENOG4108W0I acetyltransferase FORC5_1447 ENOG4105KHC sulfurtransferase FORC5_1450 ENOG4106032 Glutathionylspermidine synthase FORC5_1455 ENOG4105HTX biosynthesis protein FORC5_1461 ENOG4105CPK Glycosyl transferase (Group 1 FORC5_1464 ENOG4108SZE gCN5-related N-acetyltransferase FORC5_1468 ENOG41081VK Ribonuclease FORC5_1481 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FORC5_1483 ENOG4107RWR Sodium hydrogen exchanger FORC5_1484 ENOG4105CN5 Metallo-Beta-Lactamase FORC5_1485 ENOG4108Z5V transcriptional regulator, merr family FORC5_1487 ENOG4105H67 Protein of unknown function (DUF421) FORC5_1488 ENOG41080C8 DUF218 domain FORC5_1495 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FORC5_1497 ENOG4107R0U MotA TolQ exbB proton channel FORC5_1498 ENOG4105ER2 Ompa motb domain protein FORC5_1499 ENOG4107YTP response regulator receiver protein FORC5_1500 ENOG4105CBS Chea signal transduction histidine kinase FORC5_1501 ENOG4105DD5 Flagellar motor switch protein FORC5_1504 ENOG4105BZU Histidine kinase FORC5_1508 ENOG4105E1Q flagellar hook-associated protein FORC5_1509 ENOG4105DTJ flagellar hook-associated protein FORC5_1513 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FORC5_1514 ENOG4108ZC9 flagellar basal-body rod protein flgc FORC5_1515 ENOG41075Z6 flagellar hook-basal body complex protein fliE FORC5_1516 ENOG4107U2N Flagellar M-ring protein FORC5_1517 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FORC5_1523 ENOG4105BZE flagellar hook protein, FlgE FORC5_1526 ENOG4107R88 Chemotaxis protein (CheV) FORC5_1528 ENOG4105I03 Flagellin FORC5_1529 ENOG4105I03 Flagellin FORC5_1530 ENOG4105E4C Lytic transglycosylase catalytic FORC5_1532 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FORC5_1533 ENOG4105DD5 Flagellar motor switch protein FORC5_1535 ENOG4105CN7 Flagellar biosynthetic protein FliP FORC5_1536 ENOG4105VS8 Flagellar biosynthetic protein fliq FORC5_1538 ENOG4105D00 flagellar biosynthetic protein flhB FORC5_1539 ENOG4105D7B Flagellar biosynthesis protein flha FORC5_1540 ENOG4105FZW flagellar biosynthesis regulator FlhF FORC5_1541 ENOG4105KTQ flagellar basal-body rod protein FORC5_1542 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FORC5_1548 ENOG4105KAC Antibiotic biosynthesis monooxygenase FORC5_1553 ENOG4105DUM transcriptional regulator, lysR family FORC5_1554 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC5_1556 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FORC5_1562 ENOG4105CVJ phosphoglycerate mutase FORC5_1564 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FORC5_1568 ENOG4105CAQ asparagine synthetase FORC5_1572 ENOG4105PGM cation diffusion facilitator family transporter FORC5_1574 ENOG4105DRR Transcriptional regulator, GntR family FORC5_1575 ENOG4108UZ3 Transporter FORC5_1577 ENOG4105CKI cobalamin synthesis protein FORC5_1578 ENOG4108PJD permease FORC5_1581 ENOG4105DFD Na H antiporter FORC5_1582 ENOG4105VUF Transcriptional regulator FORC5_1584 ENOG4105C9Q fumarate hydratase class II FORC5_1588 ENOG4107QJQ Mate efflux family protein FORC5_1589 ENOG4105EC3 peptidase S51, dipeptidase E FORC5_1593 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC5_1631 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC5_1639 ENOG4105K63 Thioredoxin FORC5_1644 ENOG4105C2M dna polymerase I FORC5_1655 ENOG4105BZC d-serine deaminase FORC5_1656 ENOG4106BRA Membrane FORC5_1663 ENOG4105CJ1 ABC, transporter FORC5_1668 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FORC5_1670 ENOG4108IJ0 Aspartate ammonia-lyase FORC5_1671 ENOG4105C6K Malic enzyme FORC5_1677 ENOG41067QW Transcriptional regulator FORC5_1682 ENOG4105FVX FORC5_1683 ENOG4105E09 nadh pyrophosphatase FORC5_1686 ENOG4105CSR polyphosphate kinase 2 FORC5_1689 ENOG4105DXI Major Facilitator superfamily FORC5_1692 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FORC5_1693 ENOG4105EU0 Major facilitator Superfamily FORC5_1694 ENOG4105C6T cysteine synthase FORC5_1698 ENOG4105C8J )-transporter FORC5_1700 ENOG4105X5K response regulator receiver protein FORC5_1701 ENOG4105H67 Protein of unknown function (DUF421) FORC5_1705 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FORC5_1706 ENOG4105CHR reductase FORC5_1707 ENOG4105CM2 brancheD-chain amino acid aminotransferase FORC5_1708 ENOG4105C7K acetolactate synthase FORC5_1710 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FORC5_1712 ENOG4105C7B Threonine dehydratase FORC5_1716 ENOG4105C6X Major Facilitator FORC5_1717 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FORC5_1719 ENOG4105DY9 regulatoR FORC5_1720 ENOG4105CYC Transferase FORC5_1721 ENOG4105K5X acetyltransferase FORC5_1725 ENOG41068WN FORC5_1729 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FORC5_1730 ENOG4105C72 UPF0176 protein FORC5_1732 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FORC5_1733 ENOG4105C0X amino acid FORC5_1742 ENOG410849A acetyltransferase, (GNAT) family FORC5_1746 ENOG4107RHR regulatoR FORC5_1748 ENOG4105D9N nucleoside FORC5_1749 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FORC5_1760 ENOG410811B TRANSCRIPTIONal FORC5_1763 ENOG4107RAQ aminopeptidase FORC5_1765 ENOG4107R16 Multicopper oxidase FORC5_1773 ENOG4108T5E Copper resistance protein FORC5_1774 ENOG4105KTB nuclear export factor GLE1 FORC5_1775 ENOG4107RT3 EamA-like transporter family FORC5_1776 ENOG4105GZI Transcriptional regulator FORC5_1777 ENOG4108Z40 Transcriptional regulator FORC5_1778 ENOG4107ZXU DSBA oxidoreductase FORC5_1779 ENOG4108TVJ Nitroreductase FORC5_1780 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FORC5_1781 ENOG4106F5Q Membrane FORC5_1782 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FORC5_1784 ENOG4105CKI cobalamin synthesis protein FORC5_1786 ENOG4105C0Z ABC transporter FORC5_1787 ENOG4108IV0 ABC, transporter FORC5_1788 ENOG4105C32 Amino acid ABC transporter (Permease) FORC5_1790 ENOG4105SKE transcriptional Regulator LysR family FORC5_1796 ENOG4105C4M (Ubiquinol oxidase) subunit I FORC5_1797 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FORC5_1798 ENOG4108JJ9 ABC, transporter FORC5_1799 ENOG4108JJ8 (ABC) transporter FORC5_1801 ENOG4105K64 Glycosyl transferase, family 2 FORC5_1803 ENOG4108UT6 Transferase hexapeptide repeat containing protein FORC5_1814 ENOG4105BZ1 (ABC) transporter FORC5_1815 ENOG4105EFI regulatoR FORC5_1816 ENOG4105BZU Histidine kinase FORC5_1818 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FORC5_1819 ENOG4108ZJ4 polysaccharide deacetylase FORC5_1823 ENOG4105D6E homoserine dehydrogenase FORC5_1828 ENOG4108KGH TRANSCRIPTIONal FORC5_1830 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC5_1831 ENOG4105BZU Histidine kinase FORC5_1832 ENOG4107VMI polysaccharide deacetylase FORC5_1834 ENOG4105KT7 mgtC SapB transporter FORC5_1835 ENOG4105VRR gCN5-related N-acetyltransferase FORC5_1837 ENOG4105DUU IucA IucC family protein FORC5_1838 ENOG4105CEY Amp-dependent synthetase and ligase FORC5_1841 ENOG4108WBH protein TIM barrel FORC5_1842 ENOG4105YWU small acid-soluble spore protein FORC5_1844 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FORC5_1845 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC5_1854 ENOG4105KRN Transcriptional regulator, abrb family FORC5_1856 ENOG4105YVS arsR family transcriptional regulator FORC5_1857 ENOG4105CPC Aldo Keto reductase FORC5_1858 ENOG4107XZQ multidrug resistance protein FORC5_1860 ENOG4105KAF membrAne FORC5_1865 ENOG4105C8Q Methyl-accepting chemotaxis FORC5_1868 ENOG4108K88 Membrane FORC5_1869 ENOG4108WPJ Ferritin-like domain FORC5_1872 ENOG4105DEN Luciferase family FORC5_1875 ENOG4105VMI -acetyltransferase FORC5_1876 ENOG4107QM2 Aldo Keto reductase FORC5_1877 ENOG4105CKI cobalamin synthesis protein FORC5_1879 ENOG4105DSE periplasmic solute binding protein FORC5_1880 ENOG4105K4T epimerase FORC5_1882 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FORC5_1891 ENOG4107T5V SNARE associated Golgi FORC5_1894 ENOG4108PJD permease FORC5_1896 ENOG4108S4H thioesterase Superfamily protein FORC5_1897 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FORC5_1901 ENOG4105SXS Protein of unknown function (DUF456) FORC5_1902 ENOG4105C37 (CBS) domain FORC5_1906 ENOG4108Z7R Chaperone CsaA FORC5_1909 ENOG4108ZRV stage ii sporulation protein p FORC5_1911 ENOG4108VXD carboxy-peptidase FORC5_1913 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FORC5_1917 ENOG4108ZRV stage ii sporulation protein p FORC5_1919 ENOG4108X4Q Hydrolase FORC5_1922 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FORC5_1925 ENOG41087PP glycosyltransferase MGT family FORC5_1926 ENOG4108JYZ YitT family FORC5_1927 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC5_1934 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FORC5_1938 ENOG4106PAW secretion accessory protein EsaA YueB FORC5_1940 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) FORC5_1941 ENOG4108MGT Required for secretion of EsxA and EsxB FORC5_1960 ENOG4105KBJ sporulation protein ytfj FORC5_1965 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FORC5_1970 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FORC5_1972 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FORC5_1973 ENOG4105EMN RNA polymerase sigma factor FORC5_1978 ENOG4108V06 Glutathione peroxidase FORC5_1981 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FORC5_1983 ENOG4108IUE nitrate reductase beta subunit FORC5_1984 ENOG4105R3A Nitrate reductase FORC5_1986 ENOG4107V6Q Cyclic nucleotide-binding domain FORC5_1987 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FORC5_1988 ENOG4105D06 uba thif-type nad fad binding protein FORC5_1989 ENOG4105CVM Molybdenum cofactor synthesis domain protein FORC5_1990 ENOG4108ZAF Molybdopterin FORC5_1995 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FORC5_1996 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FORC5_1997 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FORC5_1998 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FORC5_1999 ENOG4108IFG nitrite reductase, (NAD(P)H) FORC5_2000 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FORC5_2007 ENOG4105MCT stage V sporulation protein S FORC5_2011 ENOG4105DQ6 Transposase FORC5_2019 ENOG4105C5H ABC transporter FORC5_2022 ENOG4108UUM single-stranded DNA-binding protein FORC5_2026 ENOG4107YX5 Pfam:DUF548 FORC5_2027 ENOG4105C75 arginyL-tRNA synthetase FORC5_2031 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FORC5_2036 ENOG4105C5S asparaginyl-tRNA synthetase FORC5_2037 ENOG4105C8J )-transporter FORC5_2041 ENOG4107XGZ Hydrolase FORC5_2042 ENOG4105CY2 Citrate transporter FORC5_2046 ENOG4105KD7 acetyltransferase FORC5_2048 ENOG4105VMP Transcriptional regulator FORC5_2049 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FORC5_2054 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FORC5_2057 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FORC5_2058 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FORC5_2060 ENOG4107RVG penicillin-binding protein FORC5_2061 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FORC5_2062 ENOG4105E9Q Acyl-transferase FORC5_2063 ENOG4108UT2 hemolysin iii FORC5_2065 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FORC5_2067 ENOG4108RCR degv family FORC5_2069 ENOG4108KF3 Electron transport protein SCO1 SenC FORC5_2070 ENOG4107Y70 Heat shock protein FORC5_2071 ENOG4105CAQ asparagine synthetase FORC5_2074 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FORC5_2075 ENOG4108MES Periplasmic binding protein FORC5_2076 ENOG4105F0I Aminotransferase FORC5_2082 ENOG4105D8X mechanosensitive ion channel FORC5_2083 ENOG4105BZU Histidine kinase FORC5_2084 ENOG4105WH1 Two component transcriptional regulator luxr family FORC5_2085 ENOG4106KNT transcriptional regulator FORC5_2086 ENOG4107ZY0 Phenazine biosynthesis-like protein FORC5_2088 ENOG4105DQ6 Transposase FORC5_2092 ENOG4105CMG Carbohydrate kinase FORC5_2093 ENOG4105C6Z Gluconate FORC5_2095 ENOG4108YV3 Protein of unknown function (DUF2711) FORC5_2101 ENOG4108IJ8 ABC transporter FORC5_2102 ENOG4105E90 ABC transporter FORC5_2109 ENOG4105C37 (CBS) domain FORC5_2114 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FORC5_2117 ENOG4107S4Y M20 DapE family protein YgeY FORC5_2118 ENOG4108TSC N-acetyltransferase FORC5_2119 ENOG4108JUB Transcriptional regulator FORC5_2120 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FORC5_2129 ENOG410841Q phosphoesterase PA-phosphatase related protein FORC5_2132 ENOG4105SZ6 Thioredoxin FORC5_2133 ENOG4105KNA -acetyltransferase FORC5_2140 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC5_2151 ENOG4105BZ4 penicillin-binding protein FORC5_2153 ENOG4105CZM Major Facilitator FORC5_2154 ENOG4105W8X HesB YadR YfhF-family protein FORC5_2156 ENOG4105DXD 2-methylcitrate dehydratase FORC5_2157 ENOG4105CR4 methylisocitrate lyase FORC5_2158 ENOG4105C1G acyl-Coa dehydrogenase FORC5_2159 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FORC5_2161 ENOG4105N14 lysine exporter protein LysE YggA FORC5_2162 ENOG4105E39 Enoyl-CoA hydratase FORC5_2165 ENOG4107RFY SbcCD D subunit FORC5_2166 ENOG4105EYH Exonuclease FORC5_2171 ENOG4105FCD Major Facilitator FORC5_2172 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FORC5_2173 ENOG4105E4F Isochorismate synthase FORC5_2174 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FORC5_2175 ENOG4105WQI isochorismatase FORC5_2176 ENOG4105CEY Amp-dependent synthetase and ligase FORC5_2177 ENOG4105WQT MbtH domain protein FORC5_2178 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC5_2181 ENOG4105K70 DNA-binding protein FORC5_2185 ENOG4105BZG amino acid carrier protein FORC5_2190 ENOG4105FE9 pseudouridine synthase FORC5_2191 ENOG4105C22 threonyL-tRNA synthetase FORC5_2192 ENOG4105C19 ABC transporter FORC5_2203 ENOG41081I9 integral membrane protein FORC5_2205 ENOG4108Y4K DNA-binding transcriptional activator FORC5_2209 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FORC5_2211 ENOG4105EYF MMPL domain protein FORC5_2215 ENOG4105WCN acetyltransferase FORC5_2219 ENOG4105C1Q protoporphyrinogen oxidase FORC5_2221 ENOG41068WN FORC5_2227 ENOG4107V2S Transcriptional regulator FORC5_2228 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FORC5_2232 ENOG4105DND Transcriptional regulator FORC5_2233 ENOG4108RPX mosc domain containing protein FORC5_2236 ENOG4105BZ1 (ABC) transporter FORC5_2237 ENOG4105BZ1 (ABC) transporter FORC5_2243 ENOG4108JCI Transcriptional regulator FORC5_2249 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) FORC5_2250 ENOG4108KPJ rna polymerase sigma factor FORC5_2255 ENOG4105F32 YngK protein FORC5_2259 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) FORC5_2260 ENOG4105RD7 BadF BadG BcrA BcrD FORC5_2261 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FORC5_2263 ENOG4105C7B Threonine dehydratase FORC5_2264 ENOG4108INS Transcriptional regulator FORC5_2266 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FORC5_2268 ENOG4105C1J atp-dependent rna helicase FORC5_2271 ENOG4108IG5 Transcriptional regulator FORC5_2274 ENOG41088CC tellurite resistance protein tehB FORC5_2276 ENOG4108I0C methyltransferase FORC5_2277 ENOG4107RA9 decarboxylase FORC5_2278 ENOG41090HR transcriptional regulator FORC5_2283 ENOG4105CIN aminoacyl-histidine dipeptidase FORC5_2289 ENOG4105KRN Transcriptional regulator, abrb family FORC5_2291 ENOG4105EJ9 Membrane FORC5_2292 ENOG4105EQK -acetyltransferase FORC5_2299 ENOG4105W8Z 4'-phosphopantetheinyl transferase FORC5_2301 ENOG4105CHR reductase FORC5_2316 ENOG4108IG5 Transcriptional regulator FORC5_2318 ENOG4105FQP Beta-lactamase FORC5_2319 ENOG4107RVG penicillin-binding protein FORC5_2322 ENOG4107RF6 penicillin-binding protein FORC5_2323 ENOG4107RF6 penicillin-binding protein FORC5_2325 ENOG4105DIN metallophosphoesterase FORC5_2327 ENOG4105CJ1 ABC, transporter FORC5_2329 ENOG4107Z3H Transcriptional regulator, TetR family FORC5_2332 ENOG4105C1G acyl-Coa dehydrogenase FORC5_2333 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FORC5_2334 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FORC5_2335 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FORC5_2336 ENOG4105E39 Enoyl-CoA hydratase FORC5_2337 ENOG4107QX3 carboxylase FORC5_2338 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FORC5_2343 ENOG4105DBI uridine monophosphokinase FORC5_2346 ENOG4105DZ1 carboxypeptidase FORC5_2349 ENOG4105T9C HD domain FORC5_2351 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FORC5_2355 ENOG41075H3 AraC family transcriptional regulator FORC5_2361 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FORC5_2363 ENOG4105CHR reductase FORC5_2364 ENOG4105KVH Transcriptional regulator FORC5_2369 ENOG4105MDS 4-oxalocrotonate tautomerase FORC5_2370 ENOG4107V2S Transcriptional regulator FORC5_2376 ENOG4105EFA 4-hydroxyphenylacetate FORC5_2379 ENOG4105CPQ Dehydrogenase FORC5_2381 ENOG410900G Protein of unknown function (DUF421) FORC5_2382 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FORC5_2385 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FORC5_2396 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FORC5_2403 ENOG4105D6E homoserine dehydrogenase FORC5_2405 ENOG4105CPF Cell wall formation (By similarity) FORC5_2406 ENOG4105ETU transcriptional activator (TenA FORC5_2411 ENOG4105VTR Integrase FORC5_2420 ENOG4105KRN Transcriptional regulator, abrb family FORC5_2427 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein FORC5_2445 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FORC5_2459 ENOG4105XSJ toxin secretion phage lysis holin FORC5_2460 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FORC5_2478 ENOG410667J hydrolase FORC5_2479 ENOG4105BZU Histidine kinase FORC5_2480 ENOG4107RF6 penicillin-binding protein FORC5_2485 ENOG4108JJB ABC transporter FORC5_2488 ENOG4108HGU Histidine kinase FORC5_2497 ENOG4105CB2 alcohol dehydrogenase FORC5_2498 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FORC5_2499 ENOG4105CJN penicillin-binding protein FORC5_2510 ENOG4107Y80 Major Facilitator superfamily FORC5_2511 ENOG4108Z5V transcriptional regulator, merr family FORC5_2515 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FORC5_2521 ENOG4107Y9U Membrane FORC5_2529 ENOG4105FCD Major Facilitator FORC5_2531 ENOG4105E09 nadh pyrophosphatase FORC5_2532 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FORC5_2540 ENOG4108NRW Phospholipase, patatin family FORC5_2541 ENOG4105KWG Pfam:DUF1696 FORC5_2543 ENOG4108YYS metal-dependent hydrolase (By similarity) FORC5_2546 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FORC5_2548 ENOG4105PKS Excinuclease abc c subunit domain protein FORC5_2556 ENOG4107VFR oxidoreductase FORC5_2562 ENOG4105PAD Hydrolase FORC5_2564 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC5_2565 ENOG4105BZU Histidine kinase FORC5_2569 ENOG4107WD8 ABC transporter, permease FORC5_2572 ENOG4105DY8 decarboxylase FORC5_2575 ENOG4108IUM Glycogen debranching enzyme FORC5_2577 ENOG4105CGH 5'-nucleotidase FORC5_2580 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FORC5_2581 ENOG4105FDR Membrane FORC5_2582 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC5_2583 ENOG4105CIS alcohol dehydrogenase FORC5_2584 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FORC5_2593 ENOG4105MSI germination protein ypeb FORC5_2599 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) FORC5_2600 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FORC5_2601 ENOG4107Z3H Transcriptional regulator, TetR family FORC5_2607 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FORC5_2610 ENOG4105E98 transcriptional regulator DeoR family FORC5_2613 ENOG41062ES Transcriptional regulator FORC5_2617 ENOG4107QKR Dehydrogenase FORC5_2619 ENOG4107RUY (E1 component), alpha subunit FORC5_2621 ENOG4105E1F short-chain dehydrogenase reductase FORC5_2622 ENOG4105RHY Pfam:UPF0157 FORC5_2629 ENOG4107SQ8 Glycine betaine FORC5_2630 ENOG4108IJ7 Glycine betaine FORC5_2635 ENOG4105E66 phosphoriboisomerase A FORC5_2636 ENOG41082BV acetyltransferase FORC5_2637 ENOG41082BV acetyltransferase FORC5_2638 ENOG4108M1A Chitin-binding protein FORC5_2643 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FORC5_2644 ENOG4105MSB protein, conserved in bacteria FORC5_2648 ENOG4108Z7F N-acetyltransferase FORC5_2652 ENOG4105EEM helicase FORC5_2655 ENOG4105C9U ATP-dependent DNA helicase RecQ FORC5_2666 ENOG4108M1A Chitin-binding protein FORC5_2669 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FORC5_2671 ENOG4105BZG amino acid carrier protein FORC5_2672 ENOG4105C26 Dehydrogenase FORC5_2673 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FORC5_2675 ENOG4105CTU Proline racemase FORC5_2676 ENOG41080HI glycine oxidase FORC5_2678 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FORC5_2685 ENOG4105DCI Phosphohydrolase FORC5_2686 ENOG4107T5V SNARE associated Golgi FORC5_2688 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FORC5_2692 ENOG4105DTQ mandelate racemase muconate lactonizing FORC5_2695 ENOG4107SET aldo keto reductase FORC5_2702 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FORC5_2703 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC5_2704 ENOG4105BZU Histidine kinase FORC5_2705 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC5_2709 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 FORC5_2712 ENOG4105DPN Oligoendopeptidase f FORC5_2713 ENOG4105EPR degv family FORC5_2725 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FORC5_2726 ENOG4106K7D Major facilitator family transporter FORC5_2729 ENOG4107BMA Transglycosylase associated protein FORC5_2732 ENOG41089UC methyltransferase, type 11 FORC5_2739 ENOG4105CHM Aminotransferase FORC5_2742 ENOG4108ZMI UPF0477 protein FORC5_2745 ENOG4105DVE abc transporter atp-binding protein FORC5_2749 ENOG4105C02 permease FORC5_2751 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FORC5_2752 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FORC5_2753 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FORC5_2754 ENOG4105D7T ABC transporter FORC5_2761 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FORC5_2768 ENOG4107VC0 DNA alkylation repair enzyme FORC5_2769 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FORC5_2770 ENOG4107VMI polysaccharide deacetylase FORC5_2772 ENOG4108ZCF integral membrane protein FORC5_2773 ENOG4105E0M Sulfatase FORC5_2774 ENOG4105C5H ABC transporter FORC5_2776 ENOG4105EYF MMPL domain protein FORC5_2777 ENOG41082JN Transcriptional regulator FORC5_2781 ENOG4105CIH Imidazole acetol-phosphate transaminase FORC5_2782 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FORC5_2783 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FORC5_2792 ENOG41069ER domain protein FORC5_2794 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FORC5_2795 ENOG4105DNP FAD linked oxidase domain protein FORC5_2797 ENOG4105MKU Transcriptional regulator FORC5_2799 ENOG4105EMN RNA polymerase sigma factor FORC5_2804 ENOG4105D4B ABC, transporter FORC5_2805 ENOG4105F5R ABC transporter FORC5_2806 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FORC5_2808 ENOG4105DKT Transcriptional regulator FORC5_2809 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) FORC5_2811 ENOG41061GT Aldolase FORC5_2814 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FORC5_2821 ENOG4105II7 pyrroline-5-carboxylate reductase FORC5_2823 ENOG4107258 Transcriptional regulator FORC5_2826 ENOG4105ECK Fatty Acid Desaturase FORC5_2828 ENOG4107RBI VanW family FORC5_2829 ENOG4105G6Z alkaline phosphatase FORC5_2831 ENOG4105VMP Transcriptional regulator FORC5_2835 ENOG41068WN FORC5_2841 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FORC5_2846 ENOG4105CKK Glycosyl transferase, family 2 FORC5_2852 ENOG4105C8Y Acetylornithine aminotransferase FORC5_2861 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FORC5_2869 ENOG4108IBT Inherit from COG: transposase FORC5_2872 ENOG4105DQ6 Transposase FORC5_2875 ENOG4108TVJ Nitroreductase FORC5_2876 ENOG4105FS7 Transcriptional regulator FORC5_2879 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FORC5_2880 ENOG4105WEC Molybdate metabolism regulator FORC5_2881 ENOG4105CMR udp-glucose 4-epimerase FORC5_2884 ENOG4108DMH HTH_ARAC FORC5_2885 ENOG4108XET gCN5-related N-acetyltransferase FORC5_2888 ENOG4108PCN EamA-like transporter family FORC5_2892 ENOG4107XJU UPF0178 protein FORC5_2899 ENOG410635A Membrane FORC5_2901 ENOG4108IQI permease FORC5_2903 ENOG4105F1N DNA alkylation repair FORC5_2905 ENOG4105BZU Histidine kinase FORC5_2906 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC5_2908 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FORC5_2914 ENOG4107RF6 penicillin-binding protein FORC5_2915 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FORC5_2919 ENOG4105E7W lamb ycsf family protein FORC5_2921 ENOG4105P4J Allophanate hydrolase, subunit 1 FORC5_2922 ENOG4107258 Transcriptional regulator FORC5_2924 ENOG4106N3A copper homeostasis protein cutc FORC5_2925 ENOG4108ZHR arsR family transcriptional regulator FORC5_2927 ENOG4105FDT acyl-CoA dehydrogenase FORC5_2930 ENOG4105DWD nucleoside recognition domain protein FORC5_2940 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FORC5_2945 ENOG4105E2A Dehydrogenase FORC5_2946 ENOG4108IJ0 Aspartate ammonia-lyase FORC5_2947 ENOG4105HDK L-asparaginase FORC5_2948 ENOG4108IMY Transcriptional regulator FORC5_2950 ENOG4108B31 Spore germination protein FORC5_2953 ENOG4105BZU Histidine kinase FORC5_2958 ENOG41075H3 AraC family transcriptional regulator FORC5_2960 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FORC5_2961 ENOG4105CUB amino acid FORC5_2962 ENOG4105II7 pyrroline-5-carboxylate reductase FORC5_2963 ENOG4108NHD germination protein FORC5_2964 ENOG4108Q8B Spore germination protein FORC5_2974 ENOG4105CGH 5'-nucleotidase FORC5_2976 ENOG4105CHJ isochorismatase hydrolase FORC5_2981 ENOG41090MY MarR family Transcriptional regulator FORC5_2986 ENOG4105F6J Alpha beta hydrolase fold FORC5_2989 ENOG4108606 TspO/MBR family FORC5_2990 ENOG4105CVP deoxyribo-dipyrimidine photolyase FORC5_2994 ENOG4105F2M alpha beta hydrolase fold-3 domain protein FORC5_2997 ENOG4108TWJ NADH dehydrogenase subunit 5 FORC5_2998 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FORC5_2999 ENOG4107VMI polysaccharide deacetylase FORC5_3000 ENOG4105KY5 gCN5-related N-acetyltransferase FORC5_3001 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FORC5_3003 ENOG4105D6J arsenicaL-resistance protein FORC5_3004 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FORC5_3005 ENOG41085FC arsR family transcriptional regulator FORC5_3007 ENOG4107P5I polyketide synthase FORC5_3008 ENOG4108IG5 Transcriptional regulator FORC5_3016 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC5_3017 ENOG41062D9 Histidine kinase FORC5_3024 ENOG4105DNP FAD linked oxidase domain protein FORC5_3026 ENOG4105C19 ABC transporter FORC5_3032 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FORC5_3033 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC5_3036 ENOG4105K6H D-cysteine desulfhydrase FORC5_3040 ENOG4105JQZ Methyltransferase FORC5_3044 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FORC5_3048 ENOG4105BZU Histidine kinase FORC5_3051 ENOG4108U05 Transcriptional regulator FORC5_3052 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 FORC5_3054 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FORC5_3060 ENOG4108JQ1 Dehydrogenase FORC5_3061 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FORC5_3067 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FORC5_3092 ENOG4108VXD carboxy-peptidase FORC5_3093 ENOG4105PNM synthesis protein FORC5_3095 ENOG4108ISG Major Facilitator FORC5_3098 ENOG4107MII Sugar-specific transcriptional regulator TrmB FORC5_3099 ENOG4105CZM Major Facilitator FORC5_3102 ENOG4105CRW Short chain fatty acid transporter FORC5_3104 ENOG4105DYS nad(p)h dehydrogenase (quinone) FORC5_3116 ENOG4108K8S endonuclease I FORC5_3120 ENOG4108Z66 YbaK ebsC protein FORC5_3121 ENOG4105CUT histidyl-tRNA synthetase FORC5_3124 ENOG4105KVH Transcriptional regulator FORC5_3125 ENOG4108RCM Nitroreductase FORC5_3131 ENOG4108PSK reductase FORC5_3144 ENOG4105C31 Tryptophanyl-tRNA synthetase FORC5_3145 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FORC5_3151 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) FORC5_3153 ENOG4105EV4 Multidrug resistance protein mdtH FORC5_3159 ENOG4105C37 (CBS) domain FORC5_3162 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FORC5_3163 ENOG4105FAW cDP-glucose 4,6-dehydratase FORC5_3165 ENOG4108SMP Nad-dependent epimerase dehydratase FORC5_3170 ENOG4105DDN Pentapeptide repeat-containing protein FORC5_3171 ENOG4105XDF Protein of unknown function (DUF1272) FORC5_3172 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FORC5_3173 ENOG4105CMG Carbohydrate kinase FORC5_3174 ENOG4105C6Z Gluconate FORC5_3175 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FORC5_3177 ENOG4105CV1 Transketolase (EC 2.2.1.1) FORC5_3178 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FORC5_3184 ENOG4105C44 Serine transporter FORC5_3188 ENOG4108TZY GntR Family Transcriptional Regulator FORC5_3189 ENOG4105D9R oxidoreductase FORC5_3198 ENOG4105JAB phenazine biosynthesis protein, phzf family FORC5_3200 ENOG4105CHR reductase FORC5_3202 ENOG4105KNA -acetyltransferase FORC5_3204 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FORC5_3205 ENOG4105KVH Transcriptional regulator FORC5_3208 ENOG4108ZJ4 polysaccharide deacetylase FORC5_3220 ENOG4105DQ6 Transposase FORC5_3222 ENOG4105CNA YD repeat protein FORC5_3223 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FORC5_3229 ENOG4105H3G oxidoreductase FORC5_3244 ENOG4108TN2 lmbE family FORC5_3246 ENOG4107R3E Citrate transporter FORC5_3248 ENOG4105WCN acetyltransferase FORC5_3249 ENOG4108MES Periplasmic binding protein FORC5_3250 ENOG4105EHG Permease protein FORC5_3251 ENOG4105DQ5 transport system permease protein FORC5_3252 ENOG4105NX3 Membrane FORC5_3256 ENOG41068WN FORC5_3257 ENOG4107CUJ Protein of unknown function (DUF2690) FORC5_3259 ENOG4107V2S Transcriptional regulator FORC5_3265 ENOG4105C98 muts2 protein FORC5_3266 ENOG4105E5K Alpha-amylase FORC5_3267 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FORC5_3268 ENOG4105DPN Oligoendopeptidase f FORC5_3274 ENOG4108A04 Beta-lactamase FORC5_3279 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FORC5_3281 ENOG41082BM Transcriptional regulator, arsr family FORC5_3282 ENOG4105CIS alcohol dehydrogenase FORC5_3286 ENOG4105CQB FAD linked oxidase domain protein FORC5_3291 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FORC5_3293 ENOG4107TPS domain protein FORC5_3294 ENOG4105CEP NADH dehydrogenase FORC5_3296 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C FORC5_3297 ENOG4108M1A Chitin-binding protein FORC5_3299 ENOG4105E1K spore germination protein FORC5_3303 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FORC5_3305 ENOG4108IAJ Nad-dependent epimerase dehydratase FORC5_3306 ENOG4105FAW cDP-glucose 4,6-dehydratase FORC5_3319 ENOG4105BZU Histidine kinase FORC5_3320 ENOG4105C5H ABC transporter FORC5_3322 ENOG4107DUR UPF0457 protein FORC5_3326 ENOG4105BZU Histidine kinase FORC5_3328 ENOG4105KT7 mgtC SapB transporter FORC5_3330 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FORC5_3331 ENOG41073R8 VanW family FORC5_3333 ENOG4108R1P FORC5_3337 ENOG4105VEQ Cold shock protein FORC5_3341 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FORC5_3345 ENOG410904N short-chain dehydrogenase reductase FORC5_3347 ENOG4106IQC argininosuccinate lyase FORC5_3350 ENOG4108IA2 Sodium pantothenate symporter FORC5_3352 ENOG4105C26 Dehydrogenase FORC5_3353 ENOG4105CHR reductase FORC5_3354 ENOG4105EWU Squalene--hopene cyclase FORC5_3356 ENOG4105FR1 rard protein FORC5_3357 ENOG410696E Membrane FORC5_3360 ENOG4105D1F ATP-binding protein FORC5_3362 ENOG4108ZAF Molybdopterin FORC5_3363 ENOG4105CVM Molybdenum cofactor synthesis domain protein FORC5_3364 ENOG4105D06 uba thif-type nad fad binding protein FORC5_3365 ENOG4105TMB Formate nitrite transporter FORC5_3367 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FORC5_3368 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FORC5_3370 ENOG4108JB9 formate dehydrogenase FORC5_3371 ENOG4105E1K spore germination protein FORC5_3374 ENOG4105CUB amino acid FORC5_3384 ENOG4107QJT sodium dicarboxylate symporter FORC5_3385 ENOG4108KGH TRANSCRIPTIONal FORC5_3387 ENOG4105EMN RNA polymerase sigma factor FORC5_3389 ENOG4105CIG ABC transporter FORC5_3391 ENOG4105D9R oxidoreductase FORC5_3393 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FORC5_3394 ENOG4105K4P CoA-binding domain protein FORC5_3395 ENOG4105C0H protease FORC5_3396 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC5_3398 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FORC5_3399 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FORC5_3400 ENOG4105W8X HesB YadR YfhF-family protein FORC5_3404 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FORC5_3405 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC5_3408 ENOG4108JJB ABC transporter FORC5_3409 ENOG4108I0Z Aconitate hydratase FORC5_3413 ENOG4105E5W Transporter FORC5_3415 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FORC5_3419 ENOG4107F3J Amp-dependent synthetase and ligase FORC5_3420 ENOG4107ZYJ bioY protein FORC5_3421 ENOG4105CEY Amp-dependent synthetase and ligase FORC5_3429 ENOG4107AYK membrAne FORC5_3432 ENOG4105BZU Histidine kinase FORC5_3433 ENOG4105FBA Phospholipase Carboxylesterase FORC5_3434 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FORC5_3435 ENOG4105CK7 Sodium proline symporter FORC5_3437 ENOG4105CBC glutamate synthase FORC5_3438 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FORC5_3439 ENOG4108VJ1 Transcriptional regulator (CarD family FORC5_3440 ENOG4108903 Formimidoylglutamase FORC5_3451 ENOG4107QIV Cytochrome c biogenesis protein FORC5_3453 ENOG4105CH2 amidohydrolase FORC5_3455 ENOG4105CJ1 ABC, transporter FORC5_3458 ENOG4107RSM transcriptional regulator FORC5_3459 ENOG4105VAW lrga family FORC5_3460 ENOG41067MG lrgb family FORC5_3467 ENOG4105BZ1 (ABC) transporter FORC5_3468 ENOG4105BZ1 (ABC) transporter FORC5_3476 ENOG4108HW3 (ABC) transporter FORC5_3477 ENOG4105CGH 5'-nucleotidase FORC5_3479 ENOG4108SVB resolvase FORC5_3483 ENOG4105K7K Transcriptional regulator FORC5_3485 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FORC5_3486 ENOG4105DR5 peptidase FORC5_3487 ENOG41065S2 pneumococcal vaccine antigen FORC5_3493 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FORC5_3494 ENOG4105C5F glutamine synthetase FORC5_3495 ENOG4105KV4 Transcriptional regulator FORC5_3496 ENOG4105CXI aluminum resistance protein FORC5_3497 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FORC5_3498 ENOG4105EN6 Membrane FORC5_3499 ENOG4106F1P AAA ATPase, central domain protein FORC5_3505 ENOG41069ER domain protein FORC5_3506 ENOG4105DM4 PTS System FORC5_3507 ENOG4105DE4 1-phosphofructokinase FORC5_3508 ENOG4105E98 transcriptional regulator DeoR family FORC5_3509 ENOG4107QW4 alcohol dehydrogenase FORC5_3510 ENOG4108SJC Membrane FORC5_3512 ENOG4105C85 amino acid FORC5_3515 ENOG4105TMB Formate nitrite transporter FORC5_3516 ENOG4105K70 DNA-binding protein FORC5_3518 ENOG4105C59 p-type ATPase FORC5_3519 ENOG410681U heavy metal transport detoxification protein FORC5_3520 ENOG4105VPX protein, conserved in bacteria FORC5_3522 ENOG4105NIV Esterase FORC5_3523 ENOG4105E0A ABC, transporter FORC5_3528 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FORC5_3529 ENOG4105D03 DNA-3-methyladenine glycosylase II FORC5_3535 ENOG4105BZU Histidine kinase FORC5_3543 ENOG41067MG lrgb family FORC5_3547 ENOG4108S3Y transcriptional regulator FORC5_3548 ENOG4105CS2 ec 3.2.1.21 FORC5_3551 ENOG4105F0V Cell wall hydrolase FORC5_3553 ENOG4105E0M Sulfatase FORC5_3554 ENOG410890F Dynamin family FORC5_3561 ENOG4105DQU oxidoreductase, subunit beta FORC5_3562 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FORC5_3563 ENOG4108IGT Dipeptidase FORC5_3564 ENOG4105MCT stage V sporulation protein S FORC5_3565 ENOG4105D48 metallophosphoesterase FORC5_3569 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FORC5_3572 ENOG4105XZV Protein of unknown function (DUF3243) FORC5_3573 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FORC5_3577 ENOG4105UIB (ABC) transporter FORC5_3578 ENOG4108JQ9 ABC transporter FORC5_3579 ENOG4105DIH basic membrane FORC5_3580 ENOG4105FDP GntR family transcriptional regulator FORC5_3581 ENOG4105CNU cell division protein FtsK FORC5_3583 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FORC5_3585 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FORC5_3587 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FORC5_3588 ENOG4108S0H Dipicolinic acid synthetase, b subunit FORC5_3589 ENOG4105E35 Dipicolinate synthase subunit A FORC5_3591 ENOG4105C1V Peptidase, M16 FORC5_3595 ENOG4105DTN riboflavin biosynthesis protein ribF FORC5_3598 ENOG4105W7A Protein of unknown function (DUF503) FORC5_3600 ENOG4105VHM ribosomal protein FORC5_3601 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FORC5_3602 ENOG4105CHV Transcription elongation factor NusA FORC5_3604 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FORC5_3606 ENOG4105DZP Membrane-associated zinc metalloprotease FORC5_3607 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FORC5_3608 ENOG4105KNE Phosphatidate cytidylyltransferase FORC5_3609 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FORC5_3611 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FORC5_3617 ENOG4108HE4 integrase family FORC5_3619 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FORC5_3620 ENOG4105C79 DNA protecting protein DprA FORC5_3621 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FORC5_3624 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FORC5_3629 ENOG4105VB6 UPF0109 protein FORC5_3633 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FORC5_3634 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FORC5_3637 ENOG4105CHR reductase FORC5_3638 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FORC5_3641 ENOG4105CB5 ATP-dependent DNA helicase recG FORC5_3642 ENOG4105DP4 dak2 domain fusion protein ylov FORC5_3643 ENOG4108ZAA Alkaline-shock protein FORC5_3645 ENOG4105FJ0 thiamine FORC5_3646 ENOG4105DJV ribulose-phosphate 3-epimerase FORC5_3647 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FORC5_3648 ENOG4105D9P serine threonine protein kinase FORC5_3649 ENOG4108ZF3 Phosphatase FORC5_3651 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FORC5_3654 ENOG4105C25 Primosomal protein n' FORC5_3655 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FORC5_3659 ENOG4105DSJ YicC domain protein FORC5_3661 ENOG4105F23 Fibronectin-binding protein FORC5_3662 ENOG4105DC7 peptidase M24 FORC5_3667 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FORC5_3670 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) FORC5_3671 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FORC5_3673 ENOG4105CD3 dihydroorotase FORC5_3677 ENOG4105C34 Pseudouridine synthase FORC5_3680 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FORC5_3682 ENOG4105DBK s4 domain protein FORC5_3683 ENOG41067XK integral membrane protein FORC5_3685 ENOG4105DFA alanine racemase domain protein FORC5_3686 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FORC5_3687 ENOG4105WR5 sporulation protein, YlmC YmxH family FORC5_3689 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC5_3691 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FORC5_3692 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FORC5_3694 ENOG4105D4A Cell wall formation (By similarity) FORC5_3695 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FORC5_3696 ENOG4105CNI cell division protein FtsW FORC5_3699 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FORC5_3700 ENOG4105CJN penicillin-binding protein FORC5_3701 ENOG4105CJN penicillin-binding protein FORC5_3704 ENOG41074B2 UPF0747 protein FORC5_3709 ENOG4105KNH Nucleic acid-binding protein FORC5_3711 ENOG41063PX domain protein FORC5_3712 ENOG4105D78 K07001 NTE family protein FORC5_3713 ENOG4105H20 Sporulation integral membrane protein YlbJ FORC5_3715 ENOG4106H78 methyltransferase FORC5_3719 ENOG4107TB6 phosphoglycerate mutase FORC5_3722 ENOG4106UY4 Inherit from COG: Scp-like extracellular FORC5_3732 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FORC5_3733 ENOG4105CNI cell division protein FtsW FORC5_3736 ENOG4108IAB Phoh family FORC5_3740 ENOG4105QA2 FORC5_3741 ENOG4105CI3 gtp-binding protein typa FORC5_3743 ENOG4105ECY inositol monophosphatase FORC5_3747 ENOG4105CXN decarboxylase FORC5_3754 ENOG4105CPP Dehydrogenase, E1 component FORC5_3756 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FORC5_3757 ENOG4108X4Q Hydrolase FORC5_3759 ENOG4105CN5 Metallo-Beta-Lactamase FORC5_3760 ENOG4107ZYR domain protein FORC5_3767 ENOG4108XRC Protein of unknown function (DUF458) FORC5_3768 ENOG4107IN1 Protein of unknown function (DUF1797) FORC5_3772 ENOG4105EPM Diguanylate phosphodiesterase FORC5_3773 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FORC5_3776 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FORC5_3778 ENOG4105UIN FORC5_3789 ENOG4108HGU Histidine kinase FORC5_3791 ENOG4105CHM Aminotransferase FORC5_3792 ENOG4105FKQ transcriptional regulator FORC5_3793 ENOG4105EG2 ABC transporter, permease FORC5_3795 ENOG4107FKK extracellular solute-binding protein family 1 FORC5_3797 ENOG4105CG3 alpha amylase, catalytic region FORC5_3805 ENOG4105CHU acetyl-coa acetyltransferase FORC5_3812 ENOG4105K7K Transcriptional regulator FORC5_3813 ENOG4105DTD Dehydrogenase FORC5_3816 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FORC5_3821 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FORC5_3824 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FORC5_3826 ENOG4105BZU Histidine kinase FORC5_3830 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FORC5_3833 ENOG4105CID antiterminator FORC5_3835 ENOG4105FDP GntR family transcriptional regulator FORC5_3837 ENOG4105CE4 GlcNAc 6-P deacetylase FORC5_3843 ENOG4107ZE5 PPIases accelerate the folding of proteins FORC5_3844 ENOG4105PTM secreted protein FORC5_3845 ENOG4105J7I hydrolase FORC5_3847 ENOG4105G6R Stage v sporulation protein ae FORC5_3849 ENOG4105CZ3 stage V sporulation protein ad FORC5_3850 ENOG41090VF Stage v sporulation protein ac FORC5_3853 ENOG4105C8J )-transporter FORC5_3854 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC5_3856 ENOG41082AN stage II sporulation protein FORC5_3857 ENOG4105DZ1 carboxypeptidase FORC5_3858 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FORC5_3859 ENOG4105DVE abc transporter atp-binding protein FORC5_3866 ENOG4105D7N magnesium and cobalt transport protein CorA FORC5_3871 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FORC5_3873 ENOG4105I3K Ferric uptake regulator, Fur family FORC5_3874 ENOG4105MZ9 stage II sporulation protein m FORC5_3877 ENOG4105CPC Aldo Keto reductase FORC5_3879 ENOG4105RHY Pfam:UPF0157 FORC5_3883 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FORC5_3885 ENOG4105ETE Transcriptional regulator (LacI family FORC5_3886 ENOG4108YM7 Gcn5-related n-acetyltransferase FORC5_3890 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FORC5_3891 ENOG4108R6K riboflavin synthase, subunit alpha FORC5_3896 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FORC5_3897 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FORC5_3899 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FORC5_3900 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FORC5_3902 ENOG4105DFD Na H antiporter FORC5_3903 ENOG4105CGH 5'-nucleotidase FORC5_3908 ENOG4105DBV ornithine carbamoyltransferase FORC5_3911 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FORC5_3914 ENOG4108IXY short-chain dehydrogenase reductase FORC5_3915 ENOG41069FQ Metallo-beta-lactamase superfamily FORC5_3916 ENOG4105II7 pyrroline-5-carboxylate reductase FORC5_3917 ENOG4105EJQ L-serine dehydratase FORC5_3922 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FORC5_3925 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FORC5_3926 ENOG4105D9U N-acetyltransferase FORC5_3928 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FORC5_3929 ENOG4108QEG Membrane FORC5_3930 ENOG4105CDA abc transporter atp-binding protein FORC5_3931 ENOG4105E5Q amino acid AbC transporter FORC5_3932 ENOG4108HW3 (ABC) transporter FORC5_3934 ENOG4105G7B Protein of unknown function (DUF2992) FORC5_3935 ENOG4105E09 nadh pyrophosphatase FORC5_3936 ENOG4108QY0 Membrane FORC5_3938 ENOG4105C7S Dehydrogenase FORC5_3939 ENOG4105CPP Dehydrogenase, E1 component FORC5_3942 ENOG4105CKM Branched-chain carboxylic acid kinase FORC5_3943 ENOG4107RDP Dehydrogenase FORC5_3945 ENOG4108JUB Transcriptional regulator FORC5_3947 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FORC5_3949 ENOG4107QQR Sporulation FORC5_3950 ENOG4105S1Z Stage IV sporulation protein B FORC5_3951 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FORC5_3952 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FORC5_3953 ENOG4105DX0 Hemolysin A FORC5_3955 ENOG4105CTB Polyprenyl synthetase FORC5_3958 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FORC5_3960 ENOG4108ZSR alkaline shock protein FORC5_3961 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FORC5_3966 ENOG410644B Stage III sporulation protein af FORC5_3968 ENOG4105KQ4 Stage iii sporulation protein ad FORC5_3969 ENOG4108CQH stage III sporulation protein AC FORC5_3970 ENOG4105KR5 Stage iii sporulation protein FORC5_3971 ENOG4105CD2 stage iii sporulation protein aa FORC5_3976 ENOG4105DC7 peptidase M24 FORC5_3979 ENOG4105CBJ Metal-dependent enzyme FORC5_3981 ENOG4107YBY Hydrolase FORC5_3984 ENOG4105K7K Transcriptional regulator FORC5_3987 ENOG41082GG biotin lipoate A B protein ligase FORC5_3988 ENOG4105WZW rhodanese family FORC5_3993 ENOG41080TC multidrug resistance protein FORC5_3999 ENOG4105CJ1 ABC, transporter FORC5_4000 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FORC5_4006 ENOG4105C0D helicase FORC5_4029 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FORC5_4030 ENOG4105C3R Methionine synthase FORC5_4032 ENOG4105C28 cystathionine FORC5_4033 ENOG4105C28 cystathionine FORC5_4037 ENOG4105C5X domain protein FORC5_4039 ENOG4105DKQ ROK family FORC5_4041 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FORC5_4043 ENOG4108UTW Plays a role in the regulation of phosphate uptake FORC5_4044 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FORC5_4045 ENOG4105C8U phosphate abc transporter FORC5_4046 ENOG4105C8U phosphate abc transporter FORC5_4047 ENOG4105EXS phosphate abc transporter FORC5_4048 ENOG4107RF6 penicillin-binding protein FORC5_4050 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FORC5_4054 ENOG4105N80 Ferric uptake regulator, Fur family FORC5_4056 ENOG4105FDK ABC transporter FORC5_4057 ENOG4108JYZ YitT family FORC5_4058 ENOG41069ZM Protein of unknown function (DUF2624) FORC5_4063 ENOG4105EGD dinuclear metal center protein, YbgI family FORC5_4066 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC5_4067 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FORC5_4071 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FORC5_4072 ENOG4105KG3 cytidine deaminase FORC5_4073 ENOG4107YR5 Diacylglycerol kinase FORC5_4074 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FORC5_4075 ENOG4105CTJ Metal Dependent Phosphohydrolase FORC5_4076 ENOG4105C9A Phoh family FORC5_4078 ENOG41068P3 sporulation protein YqfC FORC5_4080 ENOG4105KTH gatB Yqey FORC5_4082 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FORC5_4083 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FORC5_4089 ENOG4105CSA Coproporphyrinogen iii oxidase FORC5_4090 ENOG4105KVH Transcriptional regulator FORC5_4095 ENOG4105TQK DNA polymerase iii, delta' subunit FORC5_4096 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FORC5_4097 ENOG4108UK2 deaminase FORC5_4098 ENOG4105KQC Competence protein FORC5_4100 ENOG4105DXX methyltransferase FORC5_4102 ENOG4108WF2 Metal Dependent Phosphohydrolase FORC5_4104 ENOG410812S Rna-binding protein FORC5_4106 ENOG4105CQW ribosome biogenesis GTPase YqeH FORC5_4107 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FORC5_4110 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC5_4113 ENOG4108TVJ Nitroreductase FORC5_4116 ENOG4105G6Z alkaline phosphatase FORC5_4117 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FORC5_4118 ENOG4108MUZ hydrolase FORC5_4124 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FORC5_4125 ENOG4105MIR Phenylalanine 4-monooxygenase FORC5_4127 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FORC5_4135 ENOG4105S6R Iron-hydroxamate transporter permease subunit FORC5_4136 ENOG4108V5C ABC transporter FORC5_4138 ENOG4108EKI Dehydrogenase FORC5_4139 ENOG4105C28 cystathionine FORC5_4145 ENOG4107XRG penicillin-binding protein FORC5_4147 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FORC5_4149 ENOG4105CFP Peptidase U32 FORC5_4150 ENOG4105XYU peptidase (U32 family) FORC5_4151 ENOG4108VQJ O-methyltransferase FORC5_4152 ENOG4105HHA aminodeoxychorismate lyase FORC5_4156 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FORC5_4158 ENOG4105C02 permease FORC5_4160 ENOG41060CR FORC5_4161 ENOG4105C7H Helicase, RecD TraA family FORC5_4163 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FORC5_4164 ENOG4105C3J Cysteine desulfurase FORC5_4166 ENOG4105D1H recombination factor protein RarA FORC5_4167 ENOG4108VCI transcription factor, rsfa family FORC5_4168 ENOG4105CUZ uba thif-type nad fad binding protein FORC5_4170 ENOG4105CUT histidyl-tRNA synthetase FORC5_4173 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FORC5_4175 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FORC5_4176 ENOG41076HS cation diffusion facilitator family transporter FORC5_4177 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FORC5_4179 ENOG4105CKP Polysaccharide Biosynthesis Protein FORC5_4180 ENOG4108QG2 Membrane FORC5_4182 ENOG4105VIE preprotein translocase, subunit YajC FORC5_4185 ENOG41061AI Protein of unknown function (DUF2905) FORC5_4188 ENOG4108HUF Transporter FORC5_4194 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FORC5_4195 ENOG4108IYU L-aspartate oxidase FORC5_4198 ENOG4108RPX mosc domain containing protein FORC5_4199 ENOG4105CQC Prephenate dehydratase FORC5_4202 ENOG4105C19 ABC transporter FORC5_4203 ENOG4105EWM Histidine kinase FORC5_4205 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FORC5_4208 ENOG4105X36 (ribosomal) protein FORC5_4210 ENOG4105C03 ribonuclease FORC5_4213 ENOG4107QMS site-determining protein FORC5_4216 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FORC5_4217 ENOG4105DFF Rod shape-determining protein mreb FORC5_4221 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FORC5_4222 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FORC5_4224 ENOG41068KH stage VI sporulation protein D FORC5_4226 ENOG4105D52 delta-aminolevulinic acid dehydratase FORC5_4231 ENOG4105K56 Transcriptional regulator FORC5_4235 ENOG4108IUQ atp-dependent protease FORC5_4241 ENOG4108QCI YvbH-like oligomerisation region FORC5_4243 ENOG4105M59 Phosphodiesterase, mj0936 family FORC5_4244 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FORC5_4246 ENOG4108XJQ germination protein FORC5_4248 ENOG4108PCX Major Facilitator FORC5_4250 ENOG4105KBX Transcriptional regulator, TetR family FORC5_4252 ENOG4105PFC Transcriptional regulator FORC5_4254 ENOG4105DZC cytosine deaminase FORC5_4255 ENOG41067S9 phage shock protein C, PspC FORC5_4256 ENOG4108JCI Transcriptional regulator FORC5_4258 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FORC5_4259 ENOG4108Z40 Transcriptional regulator FORC5_4260 ENOG4105RHA ABC transporter, permease FORC5_4261 ENOG4108IUX (ABC) transporter FORC5_4262 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FORC5_4263 ENOG4105ER2 Ompa motb domain protein FORC5_4264 ENOG4105E14 MotA TolQ exbB proton channel FORC5_4265 ENOG4108VXD carboxy-peptidase FORC5_4267 ENOG4105E33 succinate dehydrogenase FORC5_4269 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FORC5_4271 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FORC5_4272 ENOG4105K63 Thioredoxin FORC5_4273 ENOG4105C10 Electron transfer flavoprotein FORC5_4274 ENOG4105BZJ Electron transfer flavoprotein FORC5_4275 ENOG41060WC Enoyl-CoA hydratase FORC5_4276 ENOG4107Z3H Transcriptional regulator, TetR family FORC5_4277 ENOG4105CEY Amp-dependent synthetase and ligase FORC5_4279 ENOG4105J76 Periplasmic binding protein FORC5_4280 ENOG4105S6R Iron-hydroxamate transporter permease subunit FORC5_4289 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC5_4292 ENOG4105DR4 Methyltransferase FORC5_4294 ENOG4105KFN sortase, SrtB family FORC5_4295 ENOG4105E0A ABC, transporter FORC5_4298 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FORC5_4300 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FORC5_4302 ENOG4105FE9 pseudouridine synthase FORC5_4304 ENOG4105DCG PHP domain protein FORC5_4307 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FORC5_4309 ENOG4105C5S asparaginyl-tRNA synthetase FORC5_4310 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FORC5_4312 ENOG4108RWN rrna methyltransferase FORC5_4315 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC5_4316 ENOG4105CW7 secretion protein, HlyD family FORC5_4317 ENOG4108JGH Tetr family transcriptional regulator FORC5_4318 ENOG4105CN9 Peptidase m42 family protein FORC5_4322 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FORC5_4323 ENOG4105C22 threonyL-tRNA synthetase FORC5_4324 ENOG4108TDW sporulation protein YtxC FORC5_4329 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FORC5_4330 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FORC5_4331 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FORC5_4333 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FORC5_4334 ENOG4105C2M dna polymerase I FORC5_4335 ENOG4105BZU Histidine kinase FORC5_4336 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC5_4339 ENOG4108HMX isocitrate dehydrogenase (NADP) FORC5_4340 ENOG4105BZN citrate synthase FORC5_4342 ENOG4108REF Sporulation integral membrane protein ytvi FORC5_4343 ENOG4105FS0 cytoplasmic membrane protein FORC5_4348 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FORC5_4349 ENOG4105C6K Malic enzyme FORC5_4350 ENOG4105C0B DNA polymerase III (alpha subunit) FORC5_4351 ENOG4105VV2 FORC5_4353 ENOG4105SFS phosphoesterase RecJ domain protein FORC5_4359 ENOG4105DC7 peptidase M24 FORC5_4366 ENOG4105Z7P Acetyltransferase (GNAT) family FORC5_4367 ENOG41082W1 Cupin 2, conserved barrel domain protein FORC5_4371 ENOG4107YZX Universal stress protein FORC5_4379 ENOG4108JYZ YitT family FORC5_4383 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FORC5_4385 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FORC5_4386 ENOG4105KBJ sporulation protein ytfj FORC5_4389 ENOG4105EFZ amidohydrolase FORC5_4391 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FORC5_4396 ENOG4106KR7 LysR family Transcriptional regulator FORC5_4398 ENOG4105U5Y Transcriptional regulator FORC5_4400 ENOG4105C28 cystathionine FORC5_4402 ENOG4108IBT Inherit from COG: transposase FORC5_4404 ENOG4108IBT Inherit from COG: transposase FORC5_4405 ENOG4108IBT Inherit from COG: transposase FORC5_4411 ENOG4108UW5 maltose o-acetyltransferase FORC5_4413 ENOG4105F1V Acetoin utilization protein FORC5_4414 ENOG4105W87 Cbs domain FORC5_4415 ENOG4105DGU Histone deacetylase FORC5_4418 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC5_4419 ENOG4105BZU Histidine kinase FORC5_4420 ENOG4107SNB ankyrin repeat protein YahD FORC5_4421 ENOG4105EP9 oxidoreductase FORC5_4427 ENOG4105ETE Transcriptional regulator (LacI family FORC5_4428 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FORC5_4432 ENOG4105C88 aminopeptidase FORC5_4439 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FORC5_4441 ENOG4108VDD TRNA binding domain protein FORC5_4447 ENOG4105C8F Beta-lactamase domain protein FORC5_4450 ENOG4108V15 phosphotransferase enzyme family FORC5_4451 ENOG4108IUM Glycogen debranching enzyme FORC5_4453 ENOG4107QSE Dipeptidase FORC5_4454 ENOG4105YW5 deoR family transcriptional regulator FORC5_4457 ENOG4105CBX hi0933 family FORC5_4464 ENOG4108VJ1 Transcriptional regulator (CarD family FORC5_4465 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FORC5_4466 ENOG4105CSC Glucose uptake protein FORC5_4469 ENOG4108ZAF Molybdopterin FORC5_4470 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FORC5_4471 ENOG4105CVM Molybdenum cofactor synthesis domain protein FORC5_4473 ENOG4105D06 uba thif-type nad fad binding protein FORC5_4474 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FORC5_4478 ENOG41085GJ domain protein FORC5_4480 ENOG4105DWV Homoserine O-trans-acetylase FORC5_4482 ENOG4108B31 Spore germination protein FORC5_4487 ENOG4105C8T Leucyl-tRNA synthetase FORC5_4488 ENOG410605W Major Facilitator FORC5_4489 ENOG4107S91 Sodium hydrogen exchanger FORC5_4490 ENOG4105NCW Trka-c domain protein FORC5_4493 ENOG4105C19 ABC transporter FORC5_4496 ENOG4105N5T Radical SAM Protein FORC5_4501 ENOG4105E8V Alpha Beta Hydrolase Fold protein FORC5_4502 ENOG4108Z0R Transferase FORC5_4503 ENOG4105YVM Phosphoesterase, PA-phosphatase related FORC5_4504 ENOG4105BZF Glycosyl transferase (Group 1 FORC5_4506 ENOG4105EPU Molybdenum cofactor synthesis domain protein FORC5_4508 ENOG4108MK9 spermidine N(1)-acetyltransferase FORC5_4517 ENOG4105BZU Histidine kinase FORC5_4518 ENOG4105BZU Histidine kinase FORC5_4519 ENOG4105CH6 catalase FORC5_4521 ENOG4107S9D Alpha beta hydrolase FORC5_4522 ENOG4107T7U Sulfatase FORC5_4526 ENOG4105D2X ABC transporter substrate-binding protein FORC5_4528 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FORC5_4540 ENOG4108V2W Carbonate dehydratase FORC5_4541 ENOG4105C4M (Ubiquinol oxidase) subunit I FORC5_4542 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FORC5_4550 ENOG41087YS Phage shock protein A FORC5_4556 ENOG4105BZU Histidine kinase FORC5_4557 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC5_4562 ENOG4108UGV hypoxanthine phosphoribosyltransferase FORC5_4563 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FORC5_4572 ENOG4107ZTW SNARE associated Golgi FORC5_4575 ENOG4105C19 ABC transporter FORC5_4576 ENOG41086D8 Transcriptional regulator FORC5_4578 ENOG4105CJ1 ABC, transporter FORC5_4580 ENOG41082BM Transcriptional regulator, arsr family FORC5_4590 ENOG4105C6Z Gluconate FORC5_4591 ENOG4105FDP GntR family transcriptional regulator FORC5_4595 ENOG41069H0 dihydroorotase EC 3.5.2.3 FORC5_4599 ENOG4105DTQ mandelate racemase muconate lactonizing FORC5_4600 ENOG4105CEY Amp-dependent synthetase and ligase FORC5_4601 ENOG4108IPT Naphthoate synthase FORC5_4602 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FORC5_4603 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FORC5_4604 ENOG4105E4F Isochorismate synthase FORC5_4605 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FORC5_4607 ENOG4105VEQ Cold shock protein FORC5_4613 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FORC5_4616 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FORC5_4617 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FORC5_4618 ENOG4105KT7 mgtC SapB transporter FORC5_4619 ENOG4107PBV potassium channel FORC5_4622 ENOG4105WG9 Conserved Protein FORC5_4624 ENOG4105CHM Aminotransferase FORC5_4625 ENOG4108ZB6 transcriptional regulator AsnC family FORC5_4626 ENOG4105C5I Dehydrogenase FORC5_4627 ENOG4108MUZ hydrolase FORC5_4629 ENOG4105C87 Aminotransferase class I and II FORC5_4632 ENOG4105Y38 Kinase-associated protein B FORC5_4634 ENOG4107R3E Citrate transporter FORC5_4637 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FORC5_4638 ENOG4105KA0 thioesterase Superfamily protein FORC5_4641 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FORC5_4646 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) FORC5_4647 ENOG4106YN8 Prenyltransferase FORC5_4649 ENOG41069ER domain protein FORC5_4652 ENOG4105CEP NADH dehydrogenase FORC5_4658 ENOG4105EWC Purine nucleoside phosphorylase FORC5_4661 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FORC5_4666 ENOG4108JJA ABC, transporter FORC5_4667 ENOG4105C4B ABC transporter, permease FORC5_4668 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FORC5_4678 ENOG41083MR nifu domain-containing protein FORC5_4681 ENOG4108W5N phosphatidylglycerophosphatase a FORC5_4685 ENOG4105DAX Pfam:DUF2983 FORC5_4688 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FORC5_4689 ENOG4105DYS nad(p)h dehydrogenase (quinone) FORC5_4691 ENOG4105D4U had-superfamily hydrolase, subfamily iia FORC5_4694 ENOG4105CBT Fructose-1,6-bisphosphatase FORC5_4698 ENOG4105MMD transcriptional regulator FORC5_4699 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FORC5_4700 ENOG4107TXC Transcriptional regulator FORC5_4701 ENOG41090T1 Membrane FORC5_4706 ENOG4105FAA peptidase M23 FORC5_4708 ENOG4105KZD Domain of unknown function (DUF1805) FORC5_4709 ENOG4107R8B 5'-nucleotidase FORC5_4710 ENOG4105DIW FeS assembly protein SUFB FORC5_4711 ENOG4108UNV SUF system FeS assembly protein, NifU family FORC5_4712 ENOG4105C9B Cysteine desulfurase FORC5_4713 ENOG4105JRK feS assembly protein SufD FORC5_4714 ENOG4105C3K feS assembly ATPase SufC FORC5_4715 ENOG4105D01 (LipO)protein FORC5_4716 ENOG4105D01 (LipO)protein FORC5_4717 ENOG4108UMI ABC transporter, permease FORC5_4718 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FORC5_4723 ENOG41080E8 Transcriptional regulator, Spx MgsR family FORC5_4727 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FORC5_4732 ENOG4108W8B Beta-lactamase domain protein FORC5_4733 ENOG4105C1G acyl-Coa dehydrogenase FORC5_4734 ENOG4105CHU acetyl-coa acetyltransferase FORC5_4736 ENOG4105DZ1 carboxypeptidase FORC5_4740 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FORC5_4743 ENOG4108SUT Major Facilitator Superfamily FORC5_4744 ENOG4107R7I amino acid FORC5_4747 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FORC5_4749 ENOG4107AYK membrAne FORC5_4755 ENOG4107ZTW SNARE associated Golgi FORC5_4757 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FORC5_4758 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC5_4759 ENOG4105BZU Histidine kinase FORC5_4765 ENOG4105C8Q Methyl-accepting chemotaxis FORC5_4766 ENOG4105VG1 fes assembly suf system protein FORC5_4767 ENOG4105D4Y metalloprotease FORC5_4768 ENOG4105C2I pirin domain protein FORC5_4771 ENOG4107T5V SNARE associated Golgi FORC5_4772 ENOG4107S91 Sodium hydrogen exchanger FORC5_4773 ENOG4105NCW Trka-c domain protein FORC5_4776 ENOG4108RMU ferritin dps family protein FORC5_4779 ENOG4108URH decarboxylase FORC5_4781 ENOG41090A1 ferritin FORC5_4783 ENOG4105D9N nucleoside FORC5_4784 ENOG4105D9N nucleoside FORC5_4787 ENOG4108RYK Nad-dependent epimerase dehydratase FORC5_4790 ENOG4105CV8 reductase FORC5_4791 ENOG4105F27 Major Facilitator FORC5_4792 ENOG4105KVH Transcriptional regulator FORC5_4795 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FORC5_4796 ENOG4105D4A Cell wall formation (By similarity) FORC5_4800 ENOG4105WMR Protein CrcB homolog FORC5_4801 ENOG4105WMR Protein CrcB homolog FORC5_4805 ENOG4105C5H ABC transporter FORC5_4806 ENOG4108MK9 spermidine N(1)-acetyltransferase FORC5_4807 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FORC5_4813 ENOG4108IPW abc transporter atp-binding protein FORC5_4814 ENOG4105CM4 permease protein FORC5_4819 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FORC5_4821 ENOG4105XZU Preprotein translocase, subunit SecG FORC5_4822 ENOG41067MG lrgb family FORC5_4832 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC5_4833 ENOG4105RHA ABC transporter, permease FORC5_4834 ENOG4108IUX (ABC) transporter FORC5_4835 ENOG4105BZU Histidine kinase FORC5_4836 ENOG4108W5X Transcriptional Regulator, LuxR family FORC5_4839 ENOG41090VF Stage v sporulation protein ac FORC5_4840 ENOG4105CZ3 stage V sporulation protein ad FORC5_4843 ENOG4108QY0 Membrane FORC5_4844 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FORC5_4846 ENOG4105KRI phosphocarrier protein (HPr FORC5_4848 ENOG4105CHW UPF0052 protein FORC5_4849 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FORC5_4850 ENOG4108Z4K mutator MutT protein FORC5_4852 ENOG4105C3M thioredoxin reductase FORC5_4854 ENOG4108S4C acetyltransferase FORC5_4856 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) FORC5_4858 ENOG41086DT Membrane protein of unknown function FORC5_4860 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FORC5_4861 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FORC5_4864 ENOG4107TXC Transcriptional regulator FORC5_4867 ENOG4105HMI Membrane FORC5_4868 ENOG4105DUM transcriptional regulator, lysR family FORC5_4870 ENOG4108WS4 fmn reductase FORC5_4871 ENOG4105C5H ABC transporter FORC5_4873 ENOG4105BZ1 (ABC) transporter FORC5_4875 ENOG4105CN1 protease FORC5_4876 ENOG4105CRP Part of the ABC transporter FtsEX involved in FORC5_4877 ENOG4105CAK Cell division ATP-binding protein ftsE FORC5_4880 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) FORC5_4882 ENOG4105MS2 ribosomal subunit Interface protein FORC5_4883 ENOG4105VEQ Cold shock protein FORC5_4884 ENOG41081UC Inherit from COG: Competence protein FORC5_4887 ENOG4105KVH Transcriptional regulator FORC5_4889 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FORC5_4890 ENOG4108KGH TRANSCRIPTIONal FORC5_4891 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FORC5_4892 ENOG4105C6Y Udp-glucose 6-dehydrogenase FORC5_4893 ENOG4105ESV Glycosyl transferase, family 4 FORC5_4895 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FORC5_4899 ENOG4105F8D glycoside hydrolase family 4 FORC5_4900 ENOG4105VCP PTS System FORC5_4901 ENOG4105CK1 PTS System FORC5_4903 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FORC5_4904 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FORC5_4905 ENOG4105VCP PTS System FORC5_4907 ENOG4105VZJ PTS System FORC5_4911 ENOG4105ECB domain protein FORC5_4912 ENOG4107RSM transcriptional regulator FORC5_4920 ENOG4105DAA L-lactate FORC5_4922 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FORC5_4923 ENOG4105E0M Sulfatase FORC5_4928 ENOG4107R8N Glycosyl transferase, family 2 FORC5_4929 ENOG4105C94 Transporter FORC5_4930 ENOG41069ER domain protein FORC5_4935 ENOG4105KBK Zinc finger, swim domain protein FORC5_4936 ENOG4105C0D helicase FORC5_4942 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC5_4944 ENOG4107RBB ABC transporter, permease FORC5_4945 ENOG4105C19 ABC transporter FORC5_4947 ENOG4105CXY transporter FORC5_4950 ENOG4105BZU Histidine kinase FORC5_4951 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC5_4952 ENOG4105CMR udp-glucose 4-epimerase FORC5_4954 ENOG4108KGH TRANSCRIPTIONal FORC5_4956 ENOG4105C6Y Udp-glucose 6-dehydrogenase FORC5_4960 ENOG4108KMV Glycosyl transferase (Group 1 FORC5_4961 ENOG4107XU6 Glycosyl transferase (Group 1 FORC5_4962 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FORC5_4963 ENOG4108RYC glycosyltransferase FORC5_4965 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FORC5_4967 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FORC5_4968 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FORC5_4969 ENOG4107YJ4 chain length determinant protein FORC5_4970 ENOG4105HTX biosynthesis protein FORC5_4971 ENOG4107YJ4 chain length determinant protein FORC5_4974 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FORC5_4975 ENOG4105FRN stage II sporulation protein FORC5_4978 ENOG4105DY9 regulatoR FORC5_4982 ENOG4106778 Protein of unknown function (DUF1146) FORC5_4983 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FORC5_4984 ENOG4105C8S subunit m FORC5_4985 ENOG4105D65 subunit l FORC5_4990 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FORC5_4991 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FORC5_4993 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FORC5_4994 ENOG4105BZU Histidine kinase FORC5_5004 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FORC5_5005 ENOG41062M3 atp synthase FORC5_5008 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FORC5_5009 ENOG4108UIC UPF0340 protein FORC5_5010 ENOG4108YZG isomerase FORC5_5013 ENOG4108VGI doxx family FORC5_5014 ENOG4107XC4 flavin reductase domain protein, FMN-binding FORC5_5017 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FORC5_5019 ENOG4108ZXQ stage ii sporulation protein r FORC5_5020 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FORC5_5021 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FORC5_5022 ENOG4107104 thymidine kinase FORC5_5024 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FORC5_5025 ENOG4105CBT Fructose-1,6-bisphosphatase FORC5_5026 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FORC5_5030 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FORC5_5033 ENOG4105C1G acyl-Coa dehydrogenase FORC5_5034 ENOG4105C1G acyl-Coa dehydrogenase FORC5_5035 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FORC5_5037 ENOG4105DF6 Fe-S oxidoreductase FORC5_5040 ENOG4105BZU Histidine kinase FORC5_5042 ENOG4105D4Y metalloprotease FORC5_5044 ENOG4105BZU Histidine kinase FORC5_5045 ENOG4105KCT ABC transporter FORC5_5046 ENOG4108M15 ABC transporter FORC5_5047 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FORC5_5049 ENOG4105IIU Aminopeptidase FORC5_5051 ENOG4105DU6 RNA polymerase FORC5_5053 ENOG410684U Domain of unknown function (DUF1934) FORC5_5057 ENOG4105CYW agmatinase FORC5_5059 ENOG4105DXB Major Facilitator superfamily FORC5_5060 ENOG4107SWG transcriptional regulator MERR family FORC5_5061 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FORC5_5062 ENOG4105BZ4 penicillin-binding protein FORC5_5063 ENOG4108XFG YwhD family FORC5_5064 ENOG4108Z4T Peptidase M50 FORC5_5066 ENOG41069HH 4-oxalocrotonate tautomerase FORC5_5067 ENOG4105DCI Phosphohydrolase FORC5_5068 ENOG4108MES Periplasmic binding protein FORC5_5069 ENOG4105E0A ABC, transporter FORC5_5070 ENOG4105EHG Permease protein FORC5_5071 ENOG4105DQ5 transport system permease protein FORC5_5073 ENOG4108VCI transcription factor, rsfa family FORC5_5074 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) FORC5_5075 ENOG4108IJ2 phosphate acetyltransferase FORC5_5076 ENOG4107UEZ chlorite dismutase FORC5_5078 ENOG4108VKI Cell wall hydrolase FORC5_5081 ENOG4107SVH Potassium channel protein FORC5_5083 ENOG410667J hydrolase FORC5_5084 ENOG4105VCH membrane FORC5_5086 ENOG4108TU7 Inherit from COG: (ABC) transporter FORC5_5087 ENOG4105CJ1 ABC, transporter FORC5_5088 ENOG41090WU lipolytic protein G-D-S-L family FORC5_5091 ENOG4105D6E homoserine dehydrogenase FORC5_5096 ENOG4108Y4K DNA-binding transcriptional activator FORC5_5098 ENOG4105WH1 Two component transcriptional regulator luxr family FORC5_5099 ENOG4105BZU Histidine kinase FORC5_5100 ENOG4105DWF phosphomethylpyrimidine kinase FORC5_5101 ENOG4105BZU Histidine kinase FORC5_5102 ENOG4105VCD cytoplasmic protein FORC5_5103 ENOG4105D22 carbon starvation protein FORC5_5104 ENOG4105DY9 regulatoR FORC5_5105 ENOG41079KZ Major Facilitator Superfamily FORC5_5107 ENOG4105CG5 Glycosyl transferase (Group 1 FORC5_5109 ENOG4105EN6 Membrane FORC5_5110 ENOG4106YBV Methyl-accepting chemotaxis FORC5_5112 ENOG4108S4H thioesterase Superfamily protein FORC5_5113 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) FORC5_5115 ENOG4105K64 Glycosyl transferase, family 2 FORC5_5117 ENOG4105EJV Membrane FORC5_5118 ENOG4105CKK Glycosyl transferase, family 2 FORC5_5119 ENOG4105C5H ABC transporter FORC5_5120 ENOG41067SE Tetr family transcriptional regulator FORC5_5122 ENOG4105E0X reductase FORC5_5123 ENOG4106F5Q Membrane FORC5_5126 ENOG4108NEV two component transcriptional regulator, LytTR family FORC5_5127 ENOG4108HRK Histidine kinase FORC5_5128 ENOG4107RGD Major Facilitator superfamily FORC5_5131 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FORC5_5133 ENOG4105IW1 AmiS UreI transporter FORC5_5134 ENOG4105CMR udp-glucose 4-epimerase FORC5_5135 ENOG4108UT2 hemolysin iii FORC5_5137 ENOG4105C1J atp-dependent rna helicase FORC5_5138 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) FORC5_5139 ENOG4105DPN Oligoendopeptidase f FORC5_5141 ENOG4105BZU Histidine kinase FORC5_5142 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) FORC5_5144 ENOG4105C0H protease FORC5_5145 ENOG4105Q2H domain protein FORC5_5148 ENOG4105BZU Histidine kinase FORC5_5149 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC5_5150 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FORC5_5151 ENOG4105CDU Replicative dna helicase FORC5_5153 ENOG4105BZR domain protein FORC5_5154 ENOG4108XMW Membrane FORC5_5156 ENOG4108UUM single-stranded DNA-binding protein FORC5_5158 ENOG4105C3G gtp-binding protein FORC5_5159 ENOG4105VDK protein, conserved in bacteria FORC5_5160 ENOG4105D8X mechanosensitive ion channel FORC5_5161 ENOG4108ZDA Sporulation protein YyaC FORC5_5162 ENOG4105FA0 parb-like partition protein FORC5_5163 ENOG4107QJE Chromosome Partitioning Protein FORC5_5166 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FORC5_5167 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FORC5_5169 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FORC5_t098 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation