locus-tag class description FORC24_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FORC24_0003 ENOG410848D S4 domain protein YaaA FORC24_0006 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FORC24_0008 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FORC24_0011 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) FORC24_0014 ENOG4105ZMH deoxynucleoside kinase FORC24_0016 ENOG4105GTG Isochorismatase FORC24_0017 ENOG4108Z6B deaminase FORC24_0018 ENOG4105C6E dna polymerase iii FORC24_0022 ENOG41067KS pro-sigma K processing FORC24_0024 ENOG4105CXN decarboxylase FORC24_0026 ENOG4105FA2 dna polymerase iii FORC24_0027 ENOG4105MA4 psp1 domain protein FORC24_0029 ENOG41060K3 Methyltransferase FORC24_0031 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FORC24_0032 ENOG4105KRN Transcriptional regulator, abrb family FORC24_0033 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FORC24_0034 ENOG4105F8V Hydrolase, tatD family FORC24_0035 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FORC24_0037 ENOG4105XFA sporulation peptidase YabG FORC24_0038 ENOG4105W42 Veg protein FORC24_0041 ENOG4105DFT pur operon repressor FORC24_0042 ENOG4105KME endoribonuclease L-psp FORC24_0045 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FORC24_0046 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FORC24_0048 ENOG4108JA2 transcriptioN-repair coupling factor FORC24_0049 ENOG4108M14 stage v sporulation protein t FORC24_0051 ENOG4108IY2 MazG family FORC24_0052 ENOG41082I2 s4 domain protein FORC24_0053 ENOG4105VYY sporulation protein yabp FORC24_0056 ENOG41060GV RNA binding s1 domain protein FORC24_0058 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FORC24_0059 ENOG4108UGV hypoxanthine phosphoribosyltransferase FORC24_0060 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FORC24_0063 ENOG4105C6T cysteine synthase FORC24_0064 ENOG4105CRQ synthase (Component I) FORC24_0065 ENOG4105DDQ anthranilate synthase FORC24_0066 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FORC24_0067 ENOG4105EEI dihydropteroate synthase FORC24_0068 ENOG4105KRF dihydroneopterin aldolase FORC24_0069 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FORC24_0070 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FORC24_0073 ENOG4108Z0C Uvrb UvrC protein FORC24_0076 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FORC24_0077 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) FORC24_0078 ENOG4105CTP PilT protein domain protein FORC24_0079 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FORC24_0082 ENOG4105D7W serine acetyltransferase FORC24_0085 ENOG4105C2N RNA methyltransferase TrmH family group 3 FORC24_0086 ENOG4105M0M Tetracycline resistance protein FORC24_0087 ENOG4105QIV RNA polymerase FORC24_0089 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FORC24_0094 ENOG4107Y49 methyltransferase FORC24_0097 ENOG4105XPM ribosomal protein FORC24_0118 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FORC24_0123 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FORC24_0125 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FORC24_0127 ENOG41067V7 50S ribosomal protein L36 FORC24_0132 ENOG4108JJB ABC transporter FORC24_0133 ENOG4108JJB ABC transporter FORC24_0134 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FORC24_0135 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FORC24_0140 ENOG4105D1F ATP-binding protein FORC24_0143 ENOG4108NMV polysaccharide deacetylase FORC24_0147 ENOG4105C8B TIGR00159 family FORC24_0148 ENOG4107U5W ybbr family FORC24_0150 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FORC24_0155 ENOG4108PSK reductase FORC24_0156 ENOG4108UMI ABC transporter, permease FORC24_0157 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FORC24_0158 ENOG4105D01 (LipO)protein FORC24_0159 ENOG4105CB2 alcohol dehydrogenase FORC24_0161 ENOG4105IQ5 FAD linked oxidase domain protein FORC24_0164 ENOG4105C2C drug resistance transporter, Bcr CflA FORC24_0168 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FORC24_0169 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC24_0170 ENOG4105C3U ABC transporter FORC24_0171 ENOG4108JQ7 (ABC) transporter FORC24_0177 ENOG4108J59 Extracellular solute-binding protein, family 5 FORC24_0178 ENOG4108J59 Extracellular solute-binding protein, family 5 FORC24_0181 ENOG4106Z1T Nicotinamide Mononucleotide Transporter FORC24_0183 ENOG4105E0C molybdate abc transporter FORC24_0184 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FORC24_0185 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FORC24_0186 ENOG4105EGI Transcriptional regulator FORC24_0188 ENOG4105F6E Acyl-transferase FORC24_0191 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FORC24_0194 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FORC24_0197 ENOG4105C5H ABC transporter FORC24_0199 ENOG4105DEF Extracellular solute-binding protein, family 5 FORC24_0201 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC24_0202 ENOG4105C3U ABC transporter FORC24_0203 ENOG4108JQ7 (ABC) transporter FORC24_0204 ENOG410667J hydrolase FORC24_0205 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FORC24_0206 ENOG4105ERH Fumarylacetoacetate hydrolase FORC24_0208 ENOG4105CUB amino acid FORC24_0209 ENOG4108SC4 )-transporter FORC24_0210 ENOG4105CPF Cell wall formation (By similarity) FORC24_0211 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FORC24_0216 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FORC24_0217 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FORC24_0219 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FORC24_0222 ENOG4105K8N protein family UPF0079, ATPase FORC24_0223 ENOG41072GX Peptidase M22 Glycoprotease FORC24_0224 ENOG410801F ribosomal-protein-alanine acetyltransferase FORC24_0225 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FORC24_0226 ENOG4105C5H ABC transporter FORC24_0229 ENOG4108TYN CAAX amino terminal protease family protein FORC24_0233 ENOG4105C7N Xanthine uracil vitamin C permease FORC24_0235 ENOG4105BZU Histidine kinase FORC24_0237 ENOG4107ZXU DSBA oxidoreductase FORC24_0243 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC24_0248 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) FORC24_0250 ENOG4108SHN Glycosyl transferase, family 2 FORC24_0251 ENOG4105SX7 Transporter FORC24_0254 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FORC24_0255 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FORC24_0256 ENOG4105C83 adenylosuccinate lyase FORC24_0258 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FORC24_0263 ENOG4108V3E phosphoribosylglycinamide formyltransferase FORC24_0264 ENOG4105DC1 bifunctional purine biosynthesis protein purh FORC24_0265 ENOG4105C12 Phosphoribosylglycinamide synthetase FORC24_0270 ENOG4105C4R Atp-dependent dna helicase FORC24_0271 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FORC24_0275 ENOG4108W2Y isochorismatase FORC24_0276 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FORC24_0277 ENOG4108UMI ABC transporter, permease FORC24_0278 ENOG4105D01 (LipO)protein FORC24_0279 ENOG4107I77 yiaA/B two helix domain FORC24_0281 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FORC24_0283 ENOG4105CBD Diacylglycerol kinase FORC24_0285 ENOG4108JPW Aminotransferase FORC24_0287 ENOG4105C26 Dehydrogenase FORC24_0288 ENOG4105KPY Small multidrug resistance protein FORC24_0294 ENOG4105D9N nucleoside FORC24_0295 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FORC24_0299 ENOG4108W15 Protein of unknown function (DUF1456) FORC24_0302 ENOG4105DTQ mandelate racemase muconate lactonizing FORC24_0304 ENOG4105DFD Na H antiporter FORC24_0309 ENOG4105D3R alkyl hydroperoxide reductase FORC24_0310 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FORC24_0311 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FORC24_0312 ENOG4107W7X Aldolase FORC24_0313 ENOG4105EHG Permease protein FORC24_0314 ENOG4105DQ5 transport system permease protein FORC24_0315 ENOG4108V5C ABC transporter FORC24_0316 ENOG4105CAY ferredoxin--nadp reductase FORC24_0319 ENOG4106UIA FORC24_0320 ENOG4106UIA FORC24_0323 ENOG4105BZU Histidine kinase FORC24_0327 ENOG410756H nucleotidyltransferase FORC24_0328 ENOG4105D2S major facilitator superfamily FORC24_0331 ENOG4105E5Q amino acid AbC transporter FORC24_0332 ENOG4105EAB amino acid AbC transporter FORC24_0333 ENOG4105CDA abc transporter atp-binding protein FORC24_0334 ENOG4105C8Q Methyl-accepting chemotaxis FORC24_0337 ENOG4105DBV ornithine carbamoyltransferase FORC24_0339 ENOG4105C5B carbamate kinase FORC24_0340 ENOG4108W63 CRP FNR family transcriptional regulator FORC24_0342 ENOG4105DNP FAD linked oxidase domain protein FORC24_0344 ENOG4105CI1 PTS System FORC24_0347 ENOG4105C9U ATP-dependent DNA helicase RecQ FORC24_0348 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase FORC24_0350 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FORC24_0353 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FORC24_0354 ENOG4105D2X ABC transporter substrate-binding protein FORC24_0356 ENOG4105C5H ABC transporter FORC24_0361 ENOG41062JF Transcriptional regulator FORC24_0364 ENOG4105DEU major facilitator superfamily FORC24_0367 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FORC24_0370 ENOG4108N0M stress protein FORC24_0371 ENOG4106FN3 tellurium resistance protein FORC24_0372 ENOG4106FN3 tellurium resistance protein FORC24_0373 ENOG4107TS3 membrane protein, TerC FORC24_0374 ENOG4108TTB tellurium resistance protein FORC24_0377 ENOG41068PA UPF0435 protein FORC24_0378 ENOG4105KJF protein tyrosine phosphatase FORC24_0380 ENOG4107U9T Pfam:Ribonuclease_BN FORC24_0381 ENOG4105C59 p-type ATPase FORC24_0382 ENOG4108IPJ Membrane FORC24_0384 ENOG4105C3F Signal peptidase i FORC24_0386 ENOG4107ZTW SNARE associated Golgi FORC24_0389 ENOG410606W general stress protein FORC24_0390 ENOG4105UPD Calcium Proton FORC24_0398 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FORC24_0400 ENOG4108JUB Transcriptional regulator FORC24_0402 ENOG4108IQI permease FORC24_0410 ENOG4108A04 Beta-lactamase FORC24_0412 ENOG4105CKK Glycosyl transferase, family 2 FORC24_0413 ENOG4107QQG Dehydrogenase FORC24_0414 ENOG4105C3I Nad-dependent epimerase dehydratase FORC24_0417 ENOG4105F1A Pyruvate formate-lyase FORC24_0418 ENOG4108QBV Monogalactosyldiacylglycerol synthase FORC24_0420 ENOG4105CI2 imidazolone-5-propionate hydrolase FORC24_0421 ENOG4105ECP epimerase FORC24_0427 ENOG41067AE Membrane-bound metal-dependent hydrolase FORC24_0428 ENOG4105CEN a g-specific adenine glycosylase FORC24_0429 ENOG4106BXE FORC24_0433 ENOG4105BZ1 (ABC) transporter FORC24_0434 ENOG4107NBY Membrane FORC24_0435 ENOG4105CBC glutamate synthase FORC24_0437 ENOG4108IUW ABC transporter FORC24_0441 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC24_0442 ENOG4105G5W regulator Fur family FORC24_0446 ENOG4105CDY transcriptional regulatory protein FORC24_0448 ENOG4108JQC penicillin-binding protein 1A FORC24_0449 ENOG4108R9S DSBA oxidoreductase FORC24_0450 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FORC24_0452 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FORC24_0453 ENOG4105BZU Histidine kinase FORC24_0454 ENOG4105CYN Serine protein kinase FORC24_0455 ENOG4106AKX UPF0229 protein FORC24_0463 ENOG4105EWM Histidine kinase FORC24_0481 ENOG4105C94 Transporter FORC24_0484 ENOG4105DZ6 Band 7 protein FORC24_0486 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FORC24_0487 ENOG4108V9W transcriptional regulatory protein FORC24_0488 ENOG4105D4T Citrate transporter FORC24_0493 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FORC24_0494 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC24_0495 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FORC24_0496 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FORC24_0497 ENOG4105BZ7 extracellular solute-binding protein family 1 FORC24_0498 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FORC24_0499 ENOG4108STX response regulator FORC24_0500 ENOG4105US7 Histidine kinase FORC24_0505 ENOG4108MRH transcriptional regulatory protein FORC24_0507 ENOG4105C6K Malic enzyme FORC24_0509 ENOG4108UZ3 Transporter FORC24_0510 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC24_0512 ENOG4105BZU Histidine kinase FORC24_0514 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FORC24_0515 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FORC24_0516 ENOG4108JB9 formate dehydrogenase FORC24_0520 ENOG4105CUB amino acid FORC24_0523 ENOG4105C59 p-type ATPase FORC24_0524 ENOG4105DAP Nicotinate phosphoribosyltransferase FORC24_0530 ENOG41073R8 VanW family FORC24_0531 ENOG4108KGH TRANSCRIPTIONal FORC24_0532 ENOG4105D9N nucleoside FORC24_0533 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FORC24_0534 ENOG4105C37 (CBS) domain FORC24_0535 ENOG4108IJ0 Aspartate ammonia-lyase FORC24_0536 ENOG4105DAA L-lactate FORC24_0539 ENOG4105DUX Transporter FORC24_0540 ENOG4108MES Periplasmic binding protein FORC24_0541 ENOG4105DQ5 transport system permease protein FORC24_0542 ENOG4108IHU transport system permease protein FORC24_0543 ENOG4105E0A ABC, transporter FORC24_0545 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FORC24_0546 ENOG4105EXW epimerase dehydratase FORC24_0548 ENOG4107T89 von Willebrand factor, type A FORC24_0549 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FORC24_0550 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FORC24_0552 ENOG4105BZU Histidine kinase FORC24_0553 ENOG4105D5Q Arginine ornithine antiporter FORC24_0554 ENOG4107414 GntR family transcriptional regulator FORC24_0555 ENOG4105C5Y PTS System FORC24_0556 ENOG4105CG3 alpha amylase, catalytic region FORC24_0559 ENOG4105E1K spore germination protein FORC24_0560 ENOG4108XG2 Histidine kinase FORC24_0561 ENOG4105WH1 Two component transcriptional regulator luxr family FORC24_0562 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FORC24_0564 ENOG4105CRN Aminoglycoside phosphotransferase FORC24_0565 ENOG4105BZG amino acid carrier protein FORC24_0566 ENOG4105CDA abc transporter atp-binding protein FORC24_0567 ENOG4105CT1 (ABC) transporter FORC24_0568 ENOG4105EAD ABC transporter FORC24_0569 ENOG4105DRP amino acid AbC transporter FORC24_0570 ENOG4108IQI permease FORC24_0573 ENOG4105GFR rna polymerase sigma factor FORC24_0575 ENOG4105D29 Helix-turn-helix type 11 domain protein FORC24_0576 ENOG4105NAE bifunctional deaminase-reductase domain protein FORC24_0577 ENOG4105BZU Histidine kinase FORC24_0580 ENOG4105CHH sulfate transporter FORC24_0581 ENOG41068KF Universal stress protein FORC24_0582 ENOG4105CXY transporter FORC24_0583 ENOG41067TZ transcriptional regulator, MarR family FORC24_0584 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC24_0585 ENOG4105ETE Transcriptional regulator (LacI family FORC24_0586 ENOG4108RVA ribokinase FORC24_0587 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) FORC24_0588 ENOG4105C2J ABC transporter FORC24_0589 ENOG4105CNN ABC, transporter FORC24_0590 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FORC24_0591 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FORC24_0598 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) FORC24_0604 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FORC24_0605 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FORC24_0606 ENOG41069ER domain protein FORC24_0607 ENOG4105VZ8 Transcriptional regulator FORC24_0608 ENOG4107D63 FORC24_0611 ENOG4105DUX Transporter FORC24_0615 ENOG4105C85 amino acid FORC24_0616 ENOG4105C7N Xanthine uracil vitamin C permease FORC24_0618 ENOG4105D7V transposase FORC24_0621 ENOG4105MA6 gCN5-related N-acetyltransferase FORC24_0626 ENOG4105BZ9 Cytochrome C oxidase, subunit I FORC24_0627 ENOG4105E2S oxidase) subunit II FORC24_0631 ENOG4105E1V na solute symporter FORC24_0634 ENOG4108NHD germination protein FORC24_0635 ENOG4108NHD germination protein FORC24_0636 ENOG4105CE1 Ferrous iron transport protein b FORC24_0637 ENOG4105CE1 Ferrous iron transport protein b FORC24_0638 ENOG4105CE1 Ferrous iron transport protein b FORC24_0639 ENOG4105CVA phosphate FORC24_0640 ENOG4105C8U phosphate abc transporter FORC24_0641 ENOG4105E2Z phosphate ABC transporter (Permease FORC24_0644 ENOG41080XQ Signal transduction protein with cbs domains FORC24_0648 ENOG4105ETU transcriptional activator (TenA FORC24_0650 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FORC24_0652 ENOG4108VEU Thiamine monophosphate synthase FORC24_0653 ENOG41080HI glycine oxidase FORC24_0656 ENOG4105D06 uba thif-type nad fad binding protein FORC24_0657 ENOG4105DWF phosphomethylpyrimidine kinase FORC24_0662 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) FORC24_0665 ENOG4108INS Transcriptional regulator FORC24_0670 ENOG4105C19 ABC transporter FORC24_0673 ENOG4105CNN ABC, transporter FORC24_0676 ENOG4105C7N Xanthine uracil vitamin C permease FORC24_0678 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FORC24_0682 ENOG4105C5Y PTS System FORC24_0685 ENOG4105K63 Thioredoxin FORC24_0689 ENOG4108B31 Spore germination protein FORC24_0693 ENOG4107Y03 Nitroreductase FORC24_0694 ENOG4105ED1 spovr family FORC24_0696 ENOG4105J4Q Transcriptional regulator FORC24_0699 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FORC24_0700 ENOG4105XTG Pfam:DUF156 FORC24_0701 ENOG4105VFE sira family FORC24_0702 ENOG4107TPS domain protein FORC24_0703 ENOG4105VFE sira family FORC24_0704 ENOG4105VFE sira family FORC24_0705 ENOG41085GJ domain protein FORC24_0706 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FORC24_0707 ENOG41087NI Sulfite exporter TauE/SafE FORC24_0709 ENOG4108KGH TRANSCRIPTIONal FORC24_0714 ENOG4105EMD TRANSCRIPTIONal FORC24_0715 ENOG4105VCP PTS System FORC24_0716 ENOG4105VZJ PTS System FORC24_0719 ENOG41069ER domain protein FORC24_0720 ENOG4107RBB ABC transporter, permease FORC24_0721 ENOG4105C19 ABC transporter FORC24_0727 ENOG4105WEF catalase FORC24_0734 ENOG4107T5V SNARE associated Golgi FORC24_0741 ENOG4105CUB amino acid FORC24_0742 ENOG4107RWR Sodium hydrogen exchanger FORC24_0744 ENOG4106KNT transcriptional regulator FORC24_0745 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FORC24_0752 ENOG4108YXU transcriptional regulator AsnC family FORC24_0753 ENOG4105CH7 arginosuccinase FORC24_0754 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FORC24_0756 ENOG4105KPY Small multidrug resistance protein FORC24_0762 ENOG4105NF4 modulator of drug activity FORC24_0763 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FORC24_0764 ENOG4105E5W Transporter FORC24_0766 ENOG4107RKG DJ-1/PfpI family FORC24_0767 ENOG4105CH6 catalase FORC24_0769 ENOG4105D5Q Arginine ornithine antiporter FORC24_0770 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FORC24_0772 ENOG4105C26 Dehydrogenase FORC24_0773 ENOG4105BZ1 (ABC) transporter FORC24_0774 ENOG4105BZ1 (ABC) transporter FORC24_0776 ENOG4105DRP amino acid AbC transporter FORC24_0777 ENOG4105CDA abc transporter atp-binding protein FORC24_0780 ENOG410839P FORC24_0787 ENOG4107FQX Alpha-acetolactate decarboxylase FORC24_0791 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FORC24_0792 ENOG4105D4P Coproporphyrinogen iii oxidase FORC24_0793 ENOG4105CEY Amp-dependent synthetase and ligase FORC24_0796 ENOG4105CHH sulfate transporter FORC24_0801 ENOG4105CGU Enoyl-CoA hydratase FORC24_0805 ENOG4105DER m42 family FORC24_0808 ENOG4105CTU Proline racemase FORC24_0809 ENOG4105CIF Ornithine Cyclodeaminase FORC24_0813 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC24_0815 ENOG4108JQ7 (ABC) transporter FORC24_0825 ENOG4105CSH Transporter FORC24_0827 ENOG4108MRH transcriptional regulatory protein FORC24_0837 ENOG4105CDU Replicative dna helicase FORC24_0843 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC24_0847 ENOG4105D9U N-acetyltransferase FORC24_0848 ENOG4105EKQ RNA-directed DNA polymerase FORC24_0853 ENOG4105F6J Alpha beta hydrolase fold FORC24_0862 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FORC24_0865 ENOG4105CMT Dihydroxyacetone kinase FORC24_0867 ENOG4105CMT Dihydroxyacetone kinase FORC24_0882 ENOG4105DZR Type I site-specific deoxyribonuclease FORC24_0893 ENOG4108WC5 Alpha Beta Hydrolase Fold protein FORC24_0901 ENOG4105WN5 stage II sporulation protein FORC24_0903 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC24_0905 ENOG4108MJI response regulator FORC24_0906 ENOG4105BZU Histidine kinase FORC24_0907 ENOG4105BZU Histidine kinase FORC24_0911 ENOG4105K8R UPF0145 protein FORC24_0914 ENOG4107QHE Choloylglycine hydrolase FORC24_0917 ENOG4107VRP DNA repair exonuclease FORC24_0918 ENOG4106D4I domain protein FORC24_0924 ENOG4108MUZ hydrolase FORC24_0928 ENOG4105F0F Oxalate decarboxylase FORC24_0929 ENOG41067QW Transcriptional regulator FORC24_0930 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FORC24_0933 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FORC24_0936 ENOG4105DQ6 Transposase FORC24_0937 ENOG4105IYK transposase FORC24_0938 ENOG4105DU6 RNA polymerase FORC24_0943 ENOG4105EEM helicase FORC24_0945 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC24_0950 ENOG4105K59 histidine triad (HIT) protein FORC24_0956 ENOG410905X membrane-flanked domain protein FORC24_0957 ENOG4105CKV Membrane FORC24_0965 ENOG410905X membrane-flanked domain protein FORC24_0966 ENOG4105CKV Membrane FORC24_0967 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FORC24_0968 ENOG4105BZ4 penicillin-binding protein FORC24_0970 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FORC24_0971 ENOG4105C1Q protoporphyrinogen oxidase FORC24_0976 ENOG4105NA0 Transcriptional regulator FORC24_0979 ENOG4105ECB domain protein FORC24_0979 ENOG4105ECB domain protein FORC24_0981 ENOG4108MK9 spermidine N(1)-acetyltransferase FORC24_0983 ENOG4108RQ5 Beta-lactamase domain-containing protein FORC24_0984 ENOG4105DF9 Lipoate-protein, ligase FORC24_0986 ENOG4105CEY Amp-dependent synthetase and ligase FORC24_0988 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FORC24_0989 ENOG4108I5D sulfate abc transporter FORC24_0990 ENOG4105ECW sulfate abc transporter FORC24_0991 ENOG4108IJ6 ABC transporter FORC24_1004 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) FORC24_1005 ENOG4107RN3 metallophosphoesterase FORC24_1006 ENOG4107TVP HD domain protein FORC24_1008 ENOG4108AEY RNA polymerase sigma factor FORC24_1009 ENOG41086D8 Transcriptional regulator FORC24_1012 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC24_1016 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FORC24_1017 ENOG4105C8Q Methyl-accepting chemotaxis FORC24_1018 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) FORC24_1020 ENOG4107QP3 malate synthase g FORC24_1025 ENOG4105VEQ Cold shock protein FORC24_1030 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FORC24_1031 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FORC24_1039 ENOG4105ERH Fumarylacetoacetate hydrolase FORC24_1041 ENOG4105C8Y Acetylornithine aminotransferase FORC24_1042 ENOG4106BKT UPF0344 protein FORC24_1044 ENOG4105CAQ asparagine synthetase FORC24_1045 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FORC24_1046 ENOG4105CH6 catalase FORC24_1047 ENOG4105BZU Histidine kinase FORC24_1050 ENOG4108VPT UPF0234 protein FORC24_1051 ENOG4105QNR S1 RNA binding domain protein FORC24_1052 ENOG4105CNA YD repeat protein FORC24_1057 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC24_1058 ENOG4107AYK membrAne FORC24_1059 ENOG41073B9 FORC24_1060 ENOG4108KP7 hydrolase FORC24_1062 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FORC24_1067 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FORC24_1068 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FORC24_1071 ENOG4105C31 Tryptophanyl-tRNA synthetase FORC24_1074 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FORC24_1075 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC24_1077 ENOG4108JQ7 (ABC) transporter FORC24_1078 ENOG4105UQX Mate efflux family protein FORC24_1082 ENOG4108ZCF integral membrane protein FORC24_1084 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FORC24_1086 ENOG4105DPN Oligoendopeptidase f FORC24_1089 ENOG4108Z18 K06886 hemoglobin FORC24_1090 ENOG4105MIX Adenylate cyclase FORC24_1091 ENOG4106EFP UPF0738 protein FORC24_1093 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FORC24_1094 ENOG4105EMS pseudouridine synthase FORC24_1098 ENOG4105K64 Glycosyl transferase, family 2 FORC24_1102 ENOG4107TVC Glycosyl transferase, family 2 FORC24_1106 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FORC24_1107 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FORC24_1109 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FORC24_1119 ENOG4108ZMI UPF0477 protein FORC24_1124 ENOG4105CK7 Sodium proline symporter FORC24_1125 ENOG4105CRQ synthase (Component I) FORC24_1126 ENOG4105DDQ anthranilate synthase FORC24_1128 ENOG4105DK0 Indole-3-glycerol phosphate synthase FORC24_1131 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FORC24_1144 ENOG4105C7S Dehydrogenase FORC24_1146 ENOG4105VZ8 Transcriptional regulator FORC24_1156 ENOG4105DZ1 carboxypeptidase FORC24_1157 ENOG4105VFR signal peptidase FORC24_1164 ENOG4105C26 Dehydrogenase FORC24_1165 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC24_1166 ENOG4105F38 ABC transporter, permease FORC24_1167 ENOG4105D38 putrescine abc transporter FORC24_1168 ENOG4107RUE extracellular solute-binding protein family 1 FORC24_1170 ENOG4105EYF MMPL domain protein FORC24_1172 ENOG4108YBP pseudouridine synthase FORC24_1174 ENOG4105K4I Scp-like extracellular FORC24_1175 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FORC24_1176 ENOG4105CQB FAD linked oxidase domain protein FORC24_1179 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC24_1180 ENOG4105BZU Histidine kinase FORC24_1181 ENOG4105JXH GntR family transcriptional regulator FORC24_1185 ENOG4106A3R peptidase FORC24_1187 ENOG4108QTI )-transporter FORC24_1188 ENOG4107TS3 membrane protein, TerC FORC24_1189 ENOG4105CZN Potassium uptake protein FORC24_1190 ENOG410681C small acid-soluble spore protein FORC24_1191 ENOG4108Z7G MaoC domain protein dehydratase FORC24_1195 ENOG4105CHR reductase FORC24_1201 ENOG4105C4Y ABC transporter FORC24_1202 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC24_1203 ENOG4107RCV ABC transporter, permease FORC24_1207 ENOG4105E98 transcriptional regulator DeoR family FORC24_1209 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FORC24_1212 ENOG4105PXI polysaccharide deacetylase FORC24_1214 ENOG4105BZU Histidine kinase FORC24_1216 ENOG41090MY MarR family Transcriptional regulator FORC24_1218 ENOG4106DF1 FORC24_1219 ENOG4105BZU Histidine kinase FORC24_1220 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FORC24_1221 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FORC24_1222 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FORC24_1229 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FORC24_1230 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FORC24_1231 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FORC24_1232 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FORC24_1233 ENOG4105CZV ABC transporter FORC24_1235 ENOG4105CJ1 ABC, transporter FORC24_1243 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FORC24_1244 ENOG4105EA8 2-Nitropropane dioxygenase FORC24_1245 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FORC24_1247 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FORC24_1251 ENOG4105NQC Flavodoxin FORC24_1259 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FORC24_1265 ENOG4105CZN Potassium uptake protein FORC24_1266 ENOG41063Y9 FORC24_1267 ENOG4105KBJ sporulation protein ytfj FORC24_1271 ENOG4105CM2 brancheD-chain amino acid aminotransferase FORC24_1272 ENOG4105C7K acetolactate synthase FORC24_1273 ENOG4108ZP8 Acetolactate synthase small subunit FORC24_1274 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FORC24_1277 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FORC24_1280 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FORC24_1281 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FORC24_1282 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FORC24_1283 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FORC24_1284 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FORC24_1285 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FORC24_1286 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FORC24_1287 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase FORC24_1288 ENOG4107RVV histidinol phosphate phosphatase, hisj family FORC24_1291 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FORC24_1292 ENOG4105E0M Sulfatase FORC24_1294 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FORC24_1296 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FORC24_1298 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FORC24_1299 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FORC24_1308 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FORC24_1309 ENOG4105E0M Sulfatase FORC24_1310 ENOG4105E0M Sulfatase FORC24_1312 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FORC24_1314 ENOG4107S4M Sulfate adenylate transferase FORC24_1315 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FORC24_1316 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FORC24_1318 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FORC24_1319 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FORC24_1320 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FORC24_1321 ENOG4105C8J )-transporter FORC24_1325 ENOG4105DFD Na H antiporter FORC24_1329 ENOG4105ENE Histidine kinase FORC24_1330 ENOG4105WH1 Two component transcriptional regulator luxr family FORC24_1334 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FORC24_1339 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FORC24_1343 ENOG4105CJ3 phosphate transporter FORC24_1344 ENOG4107GRR phosphate transport regulator FORC24_1345 ENOG4105BZ4 penicillin-binding protein FORC24_1348 ENOG4105BZU Histidine kinase FORC24_1349 ENOG4105I3N Conserved Protein FORC24_1352 ENOG4105BZU Histidine kinase FORC24_1353 ENOG4105D3A purine nucleoside phosphorylase DeoD-type FORC24_1358 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FORC24_1359 ENOG4105DZ1 carboxypeptidase FORC24_1360 ENOG4108JIC nucleoside recognition domain protein FORC24_1362 ENOG4105FE9 pseudouridine synthase FORC24_1363 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC24_1364 ENOG4107TWT Cytochrome c biogenesis protein FORC24_1365 ENOG4105CRE cytochrome C FORC24_1366 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC24_1367 ENOG4105BZU Histidine kinase FORC24_1368 ENOG4108WBT adenosyltransferase FORC24_1371 ENOG4108SAX Membrane FORC24_1374 ENOG4105C9U ATP-dependent DNA helicase RecQ FORC24_1375 ENOG4105I7S Abortive infection protein FORC24_1377 ENOG4107RGJ metallophosphoesterase FORC24_1378 ENOG4108XDN Transcriptional regulator FORC24_1379 ENOG4108S6Z Negative regulator of genetic competence FORC24_1384 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FORC24_1385 ENOG4107RB3 L-asparaginase FORC24_1388 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FORC24_1390 ENOG4105S2F FORC24_1396 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FORC24_1399 ENOG4105XXQ heptaprenyl diphosphate synthase component I FORC24_1401 ENOG4105EAH synthase FORC24_1402 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FORC24_1403 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FORC24_1404 ENOG4105D49 3-dehydroquinate synthase FORC24_1406 ENOG41068YB TPR repeat-containing protein FORC24_1409 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FORC24_1410 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FORC24_1417 ENOG4108JYZ YitT family FORC24_1418 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FORC24_1419 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FORC24_1421 ENOG4105FJR Lmbe family FORC24_1422 ENOG4105CPK Glycosyl transferase (Group 1 FORC24_1426 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FORC24_1427 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) FORC24_1429 ENOG4105DVT helicase FORC24_1430 ENOG4105YAC FORC24_1434 ENOG4105CSM endonuclease III FORC24_1436 ENOG4105BZ4 penicillin-binding protein FORC24_1445 ENOG4106F55 Protein of unknown function (DUF1273) FORC24_1447 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FORC24_1449 ENOG4105DVT helicase FORC24_1450 ENOG4105CTD carboxy-peptidase FORC24_1452 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FORC24_1453 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) FORC24_1454 ENOG4105C2W permease FORC24_1455 ENOG4105DHF Membrane FORC24_1457 ENOG410890F Dynamin family FORC24_1459 ENOG4108W0I acetyltransferase FORC24_1461 ENOG4105KHC sulfurtransferase FORC24_1469 ENOG4105HTX biosynthesis protein FORC24_1475 ENOG4105CPK Glycosyl transferase (Group 1 FORC24_1479 ENOG4108SZE gCN5-related N-acetyltransferase FORC24_1483 ENOG41081VK Ribonuclease FORC24_1496 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FORC24_1498 ENOG4107RWR Sodium hydrogen exchanger FORC24_1499 ENOG4105CN5 Metallo-Beta-Lactamase FORC24_1500 ENOG4108Z5V transcriptional regulator, merr family FORC24_1502 ENOG4105H67 Protein of unknown function (DUF421) FORC24_1503 ENOG41080C8 DUF218 domain FORC24_1510 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FORC24_1512 ENOG4107R0U MotA TolQ exbB proton channel FORC24_1513 ENOG4105ER2 Ompa motb domain protein FORC24_1514 ENOG4107YTP response regulator receiver protein FORC24_1515 ENOG4105CBS Chea signal transduction histidine kinase FORC24_1516 ENOG4105DD5 Flagellar motor switch protein FORC24_1519 ENOG4105BZU Histidine kinase FORC24_1523 ENOG4105E1Q flagellar hook-associated protein FORC24_1524 ENOG4105DTJ flagellar hook-associated protein FORC24_1525 ENOG4107TPX flagellar hook-associated FORC24_1527 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FORC24_1528 ENOG4108ZC9 flagellar basal-body rod protein flgc FORC24_1529 ENOG41075Z6 flagellar hook-basal body complex protein fliE FORC24_1530 ENOG4107U2N Flagellar M-ring protein FORC24_1531 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FORC24_1537 ENOG4105BZE flagellar hook protein, FlgE FORC24_1540 ENOG4107R88 Chemotaxis protein (CheV) FORC24_1542 ENOG4105I03 Flagellin FORC24_1543 ENOG4105I03 Flagellin FORC24_1544 ENOG4105I03 Flagellin FORC24_1545 ENOG4105I03 Flagellin FORC24_1546 ENOG4105E4C Lytic transglycosylase catalytic FORC24_1548 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FORC24_1549 ENOG4105DD5 Flagellar motor switch protein FORC24_1551 ENOG4105CN7 Flagellar biosynthetic protein FliP FORC24_1552 ENOG4105VS8 Flagellar biosynthetic protein fliq FORC24_1554 ENOG4105D00 flagellar biosynthetic protein flhB FORC24_1555 ENOG4105D7B Flagellar biosynthesis protein flha FORC24_1556 ENOG4105FZW flagellar biosynthesis regulator FlhF FORC24_1557 ENOG4105KTQ flagellar basal-body rod protein FORC24_1558 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FORC24_1565 ENOG4105KAC Antibiotic biosynthesis monooxygenase FORC24_1570 ENOG4105DUM transcriptional regulator, lysR family FORC24_1573 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FORC24_1574 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FORC24_1579 ENOG4105CVJ phosphoglycerate mutase FORC24_1581 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FORC24_1585 ENOG4105CAQ asparagine synthetase FORC24_1589 ENOG4105PGM cation diffusion facilitator family transporter FORC24_1590 ENOG4105DRR Transcriptional regulator, GntR family FORC24_1591 ENOG4108UZ3 Transporter FORC24_1593 ENOG4105CKI cobalamin synthesis protein FORC24_1594 ENOG4108PJD permease FORC24_1597 ENOG4105DFD Na H antiporter FORC24_1598 ENOG4105VUF Transcriptional regulator FORC24_1600 ENOG4105C9Q fumarate hydratase class II FORC24_1603 ENOG4107QJQ Mate efflux family protein FORC24_1604 ENOG4105EC3 peptidase S51, dipeptidase E FORC24_1608 ENOG4107QIV Cytochrome c biogenesis protein FORC24_1612 ENOG4105BZC d-serine deaminase FORC24_1613 ENOG4106BRA Membrane FORC24_1620 ENOG4105CJ1 ABC, transporter FORC24_1624 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FORC24_1626 ENOG4108IJ0 Aspartate ammonia-lyase FORC24_1627 ENOG4105C6K Malic enzyme FORC24_1637 ENOG4105FVX FORC24_1638 ENOG4105E09 nadh pyrophosphatase FORC24_1642 ENOG4105CSR polyphosphate kinase 2 FORC24_1643 ENOG4105U3E Transcriptional regulator FORC24_1646 ENOG4105DXI Major Facilitator superfamily FORC24_1649 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FORC24_1650 ENOG4105EU0 Major facilitator Superfamily FORC24_1651 ENOG4105C6T cysteine synthase FORC24_1655 ENOG4105C8J )-transporter FORC24_1657 ENOG4105X5K response regulator receiver protein FORC24_1658 ENOG4105H67 Protein of unknown function (DUF421) FORC24_1662 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FORC24_1663 ENOG4105CHR reductase FORC24_1664 ENOG4105CM2 brancheD-chain amino acid aminotransferase FORC24_1665 ENOG4105C7K acetolactate synthase FORC24_1666 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FORC24_1667 ENOG4105C01 Dihydroxy-acid dehydratase FORC24_1668 ENOG4105C7B Threonine dehydratase FORC24_1673 ENOG4105C6X Major Facilitator FORC24_1674 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FORC24_1676 ENOG4105DY9 regulatoR FORC24_1677 ENOG4105CYC Transferase FORC24_1678 ENOG4105K5X acetyltransferase FORC24_1682 ENOG41068WN FORC24_1686 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FORC24_1687 ENOG4105C72 UPF0176 protein FORC24_1689 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FORC24_1690 ENOG4105C0X amino acid FORC24_1699 ENOG410849A acetyltransferase, (GNAT) family FORC24_1700 ENOG4105K8R UPF0145 protein FORC24_1703 ENOG4107RHR regulatoR FORC24_1705 ENOG4105D9N nucleoside FORC24_1706 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FORC24_1710 ENOG4107RAQ aminopeptidase FORC24_1712 ENOG4107R16 Multicopper oxidase FORC24_1720 ENOG4108T5E Copper resistance protein FORC24_1721 ENOG4105KTB nuclear export factor GLE1 FORC24_1722 ENOG4107RT3 EamA-like transporter family FORC24_1723 ENOG4105GZI Transcriptional regulator FORC24_1724 ENOG4108Z40 Transcriptional regulator FORC24_1725 ENOG4107ZXU DSBA oxidoreductase FORC24_1726 ENOG4108TVJ Nitroreductase FORC24_1727 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FORC24_1728 ENOG4106F5Q Membrane FORC24_1729 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FORC24_1732 ENOG4105CKI cobalamin synthesis protein FORC24_1734 ENOG4105C0Z ABC transporter FORC24_1735 ENOG4108IV0 ABC, transporter FORC24_1736 ENOG4105C32 Amino acid ABC transporter (Permease) FORC24_1738 ENOG4105SKE transcriptional Regulator LysR family FORC24_1740 ENOG4105MDS 4-oxalocrotonate tautomerase FORC24_1744 ENOG4105C4M (Ubiquinol oxidase) subunit I FORC24_1745 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FORC24_1746 ENOG4108JJ9 ABC, transporter FORC24_1747 ENOG4108JJ8 (ABC) transporter FORC24_1749 ENOG4105K64 Glycosyl transferase, family 2 FORC24_1751 ENOG4108UT6 Transferase hexapeptide repeat containing protein FORC24_1762 ENOG4105BZ1 (ABC) transporter FORC24_1763 ENOG4105EFI regulatoR FORC24_1764 ENOG4105BZU Histidine kinase FORC24_1766 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FORC24_1767 ENOG4108ZJ4 polysaccharide deacetylase FORC24_1771 ENOG4105D6E homoserine dehydrogenase FORC24_1773 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FORC24_1776 ENOG4108KGH TRANSCRIPTIONal FORC24_1778 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC24_1779 ENOG4105BZU Histidine kinase FORC24_1780 ENOG4107VMI polysaccharide deacetylase FORC24_1782 ENOG4105KT7 mgtC SapB transporter FORC24_1783 ENOG4105VRR gCN5-related N-acetyltransferase FORC24_1785 ENOG4105DUU IucA IucC family protein FORC24_1786 ENOG4105CEY Amp-dependent synthetase and ligase FORC24_1789 ENOG4108WBH protein TIM barrel FORC24_1790 ENOG4105YWU small acid-soluble spore protein FORC24_1792 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FORC24_1793 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC24_1802 ENOG4105KRN Transcriptional regulator, abrb family FORC24_1806 ENOG4105KAF membrAne FORC24_1811 ENOG4105C8Q Methyl-accepting chemotaxis FORC24_1814 ENOG4108K88 Membrane FORC24_1815 ENOG4108WPJ Ferritin-like domain FORC24_1818 ENOG4105DEN Luciferase family FORC24_1821 ENOG4105VMI -acetyltransferase FORC24_1822 ENOG4105DQ6 Transposase FORC24_1824 ENOG4107QM2 Aldo Keto reductase FORC24_1825 ENOG4105CKI cobalamin synthesis protein FORC24_1827 ENOG4105DSE periplasmic solute binding protein FORC24_1829 ENOG4105K4T epimerase FORC24_1830 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FORC24_1831 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FORC24_1840 ENOG4107T5V SNARE associated Golgi FORC24_1843 ENOG4108PJD permease FORC24_1845 ENOG4108S4H thioesterase Superfamily protein FORC24_1846 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FORC24_1850 ENOG4105SXS Protein of unknown function (DUF456) FORC24_1851 ENOG4105C37 (CBS) domain FORC24_1855 ENOG4108Z7R Chaperone CsaA FORC24_1858 ENOG4108ZRV stage ii sporulation protein p FORC24_1860 ENOG4108VXD carboxy-peptidase FORC24_1862 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FORC24_1866 ENOG4108ZRV stage ii sporulation protein p FORC24_1868 ENOG4108X4Q Hydrolase FORC24_1871 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FORC24_1874 ENOG41087PP glycosyltransferase MGT family FORC24_1875 ENOG4108JYZ YitT family FORC24_1876 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC24_1886 ENOG4106PAW secretion accessory protein EsaA YueB FORC24_1888 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) FORC24_1889 ENOG4108MGT Required for secretion of EsxA and EsxB FORC24_1911 ENOG4105KBJ sporulation protein ytfj FORC24_1916 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FORC24_1920 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) FORC24_1921 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FORC24_1923 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FORC24_1924 ENOG4105EMN RNA polymerase sigma factor FORC24_1926 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) FORC24_1928 ENOG4105CNW domain protein FORC24_1930 ENOG4108V06 Glutathione peroxidase FORC24_1933 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FORC24_1935 ENOG4108IUE nitrate reductase beta subunit FORC24_1936 ENOG4105R3A Nitrate reductase FORC24_1938 ENOG4107V6Q Cyclic nucleotide-binding domain FORC24_1939 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FORC24_1940 ENOG4105D06 uba thif-type nad fad binding protein FORC24_1941 ENOG4105CVM Molybdenum cofactor synthesis domain protein FORC24_1942 ENOG4108ZAF Molybdopterin FORC24_1947 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FORC24_1948 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FORC24_1949 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FORC24_1950 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FORC24_1951 ENOG4108IFG nitrite reductase, (NAD(P)H) FORC24_1952 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FORC24_1959 ENOG4105MCT stage V sporulation protein S FORC24_1967 ENOG4105C5H ABC transporter FORC24_1978 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FORC24_1982 ENOG4105CJ3 phosphate transporter FORC24_1986 ENOG41067QW Transcriptional regulator FORC24_1988 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FORC24_1993 ENOG41082YX Transcriptional regulator, arsr family FORC24_1994 ENOG4105D6J arsenicaL-resistance protein FORC24_2003 ENOG4108UUM single-stranded DNA-binding protein FORC24_2007 ENOG4107YX5 Pfam:DUF548 FORC24_2008 ENOG4105C75 arginyL-tRNA synthetase FORC24_2014 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FORC24_2019 ENOG4105C5S asparaginyl-tRNA synthetase FORC24_2020 ENOG4105C8J )-transporter FORC24_2024 ENOG4107XGZ Hydrolase FORC24_2025 ENOG4105CY2 Citrate transporter FORC24_2029 ENOG4105KD7 acetyltransferase FORC24_2031 ENOG4105VMP Transcriptional regulator FORC24_2032 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FORC24_2037 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FORC24_2040 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FORC24_2041 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FORC24_2043 ENOG4107RVG penicillin-binding protein FORC24_2044 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FORC24_2045 ENOG4105E9Q Acyl-transferase FORC24_2046 ENOG4108UT2 hemolysin iii FORC24_2048 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FORC24_2050 ENOG4108RCR degv family FORC24_2052 ENOG4108KF3 Electron transport protein SCO1 SenC FORC24_2053 ENOG4107Y70 Heat shock protein FORC24_2054 ENOG4105CAQ asparagine synthetase FORC24_2057 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FORC24_2058 ENOG4108MES Periplasmic binding protein FORC24_2059 ENOG4105F0I Aminotransferase FORC24_2064 ENOG4105D8X mechanosensitive ion channel FORC24_2065 ENOG4105BZU Histidine kinase FORC24_2066 ENOG4105WH1 Two component transcriptional regulator luxr family FORC24_2067 ENOG4106KNT transcriptional regulator FORC24_2068 ENOG4107ZY0 Phenazine biosynthesis-like protein FORC24_2072 ENOG4105CMG Carbohydrate kinase FORC24_2073 ENOG4105C6Z Gluconate FORC24_2075 ENOG4108YV3 Protein of unknown function (DUF2711) FORC24_2081 ENOG4108IJ8 ABC transporter FORC24_2082 ENOG4105E90 ABC transporter FORC24_2089 ENOG4105C37 (CBS) domain FORC24_2094 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FORC24_2097 ENOG4107S4Y M20 DapE family protein YgeY FORC24_2098 ENOG4108TSC N-acetyltransferase FORC24_2099 ENOG4108JUB Transcriptional regulator FORC24_2100 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FORC24_2106 ENOG410841Q phosphoesterase PA-phosphatase related protein FORC24_2108 ENOG4105SZ6 Thioredoxin FORC24_2117 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC24_2129 ENOG4105BZ4 penicillin-binding protein FORC24_2131 ENOG4105CZM Major Facilitator FORC24_2132 ENOG4105W8X HesB YadR YfhF-family protein FORC24_2134 ENOG4105DXD 2-methylcitrate dehydratase FORC24_2135 ENOG4105CR4 methylisocitrate lyase FORC24_2136 ENOG4105C1G acyl-Coa dehydrogenase FORC24_2137 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FORC24_2139 ENOG4105N14 lysine exporter protein LysE YggA FORC24_2140 ENOG4105E39 Enoyl-CoA hydratase FORC24_2143 ENOG4107RFY SbcCD D subunit FORC24_2144 ENOG4105EYH Exonuclease FORC24_2150 ENOG4105FCD Major Facilitator FORC24_2151 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FORC24_2152 ENOG4105E4F Isochorismate synthase FORC24_2153 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FORC24_2154 ENOG4105WQI isochorismatase FORC24_2155 ENOG4105CEY Amp-dependent synthetase and ligase FORC24_2156 ENOG4105WQT MbtH domain protein FORC24_2157 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC24_2160 ENOG4105K70 DNA-binding protein FORC24_2164 ENOG4105BZG amino acid carrier protein FORC24_2168 ENOG4105FE9 pseudouridine synthase FORC24_2169 ENOG4105C22 threonyL-tRNA synthetase FORC24_2170 ENOG4105C19 ABC transporter FORC24_2177 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FORC24_2181 ENOG41081I9 integral membrane protein FORC24_2183 ENOG4108Y4K DNA-binding transcriptional activator FORC24_2190 ENOG4105EYF MMPL domain protein FORC24_2195 ENOG4105WCN acetyltransferase FORC24_2200 ENOG4105C1Q protoporphyrinogen oxidase FORC24_2202 ENOG41068WN FORC24_2208 ENOG4107V2S Transcriptional regulator FORC24_2209 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FORC24_2213 ENOG4105DND Transcriptional regulator FORC24_2214 ENOG4108RPX mosc domain containing protein FORC24_2217 ENOG4105BZ1 (ABC) transporter FORC24_2218 ENOG4105BZ1 (ABC) transporter FORC24_2222 ENOG4108JCI Transcriptional regulator FORC24_2228 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) FORC24_2229 ENOG4108KPJ rna polymerase sigma factor FORC24_2233 ENOG4105F32 YngK protein FORC24_2237 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) FORC24_2238 ENOG4105RD7 BadF BadG BcrA BcrD FORC24_2239 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FORC24_2240 ENOG4107STF Involved in phosphonate degradation (By similarity) FORC24_2241 ENOG4105C7B Threonine dehydratase FORC24_2242 ENOG4108INS Transcriptional regulator FORC24_2245 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FORC24_2247 ENOG4105C1J atp-dependent rna helicase FORC24_2249 ENOG4108RZE Tetr family transcriptional regulator FORC24_2252 ENOG41088CC tellurite resistance protein tehB FORC24_2254 ENOG4108I0C methyltransferase FORC24_2255 ENOG4107RA9 decarboxylase FORC24_2256 ENOG4105K56 Transcriptional regulator FORC24_2257 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FORC24_2262 ENOG4105CIN aminoacyl-histidine dipeptidase FORC24_2267 ENOG4105KRN Transcriptional regulator, abrb family FORC24_2269 ENOG4105EJ9 Membrane FORC24_2270 ENOG4105EQK -acetyltransferase FORC24_2278 ENOG4105W8Z 4'-phosphopantetheinyl transferase FORC24_2288 ENOG4105FQP Beta-lactamase FORC24_2289 ENOG4107RVG penicillin-binding protein FORC24_2293 ENOG4107RF6 penicillin-binding protein FORC24_2295 ENOG4105DIN metallophosphoesterase FORC24_2297 ENOG4105CJ1 ABC, transporter FORC24_2299 ENOG4107Z3H Transcriptional regulator, TetR family FORC24_2302 ENOG4105C1G acyl-Coa dehydrogenase FORC24_2303 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FORC24_2304 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FORC24_2305 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FORC24_2306 ENOG4105E39 Enoyl-CoA hydratase FORC24_2307 ENOG4107QX3 carboxylase FORC24_2308 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FORC24_2312 ENOG4105DBI uridine monophosphokinase FORC24_2314 ENOG4105DZ1 carboxypeptidase FORC24_2317 ENOG4105T9C HD domain FORC24_2318 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FORC24_2322 ENOG41075H3 AraC family transcriptional regulator FORC24_2330 ENOG41061TZ Short-chain dehydrogenase reductase Sdr FORC24_2331 ENOG4105KVH Transcriptional regulator FORC24_2344 ENOG4105EFA 4-hydroxyphenylacetate FORC24_2347 ENOG4105CPQ Dehydrogenase FORC24_2349 ENOG410900G Protein of unknown function (DUF421) FORC24_2350 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FORC24_2352 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FORC24_2353 ENOG4105DK7 lysyl-tRNA synthetase FORC24_2366 ENOG4105D6E homoserine dehydrogenase FORC24_2368 ENOG4105CPF Cell wall formation (By similarity) FORC24_2369 ENOG4105ETU transcriptional activator (TenA FORC24_2387 ENOG410667J hydrolase FORC24_2388 ENOG4105BZU Histidine kinase FORC24_2389 ENOG4107RF6 penicillin-binding protein FORC24_2394 ENOG4108FPN Integrase FORC24_2398 ENOG41076HS cation diffusion facilitator family transporter FORC24_2401 ENOG4107RA9 decarboxylase FORC24_2407 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FORC24_2416 ENOG4108JJB ABC transporter FORC24_2418 ENOG4108HGU Histidine kinase FORC24_2430 ENOG4105DQ6 Transposase FORC24_2434 ENOG4105CB2 alcohol dehydrogenase FORC24_2435 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FORC24_2436 ENOG4105CJN penicillin-binding protein FORC24_2437 ENOG4108IG5 Transcriptional regulator FORC24_2438 ENOG4105CHR reductase FORC24_2449 ENOG4107Y80 Major Facilitator superfamily FORC24_2450 ENOG4108Z5V transcriptional regulator, merr family FORC24_2454 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FORC24_2459 ENOG4107Y9U Membrane FORC24_2467 ENOG4105FCD Major Facilitator FORC24_2470 ENOG4105E09 nadh pyrophosphatase FORC24_2471 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FORC24_2475 ENOG4108XI2 Domain of unknown function (DUF1963) FORC24_2481 ENOG4108NRW Phospholipase, patatin family FORC24_2482 ENOG4105KWG Pfam:DUF1696 FORC24_2484 ENOG4108YYS metal-dependent hydrolase (By similarity) FORC24_2487 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FORC24_2489 ENOG4105PKS Excinuclease abc c subunit domain protein FORC24_2497 ENOG4107VFR oxidoreductase FORC24_2503 ENOG4105U0R haloacid dehalogenase-like hydrolase FORC24_2504 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC24_2505 ENOG4105BZU Histidine kinase FORC24_2509 ENOG4107WD8 ABC transporter, permease FORC24_2512 ENOG4105DY8 decarboxylase FORC24_2515 ENOG4108IUM Glycogen debranching enzyme FORC24_2517 ENOG4105CGH 5'-nucleotidase FORC24_2520 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FORC24_2521 ENOG4105FDR Membrane FORC24_2523 ENOG4105CIS alcohol dehydrogenase FORC24_2524 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FORC24_2533 ENOG4105MSI germination protein ypeb FORC24_2539 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) FORC24_2540 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FORC24_2541 ENOG4107Z3H Transcriptional regulator, TetR family FORC24_2546 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FORC24_2549 ENOG4105E98 transcriptional regulator DeoR family FORC24_2552 ENOG41062ES Transcriptional regulator FORC24_2556 ENOG4107QKR Dehydrogenase FORC24_2558 ENOG4107RUY (E1 component), alpha subunit FORC24_2560 ENOG4105E1F short-chain dehydrogenase reductase FORC24_2561 ENOG4105RHY Pfam:UPF0157 FORC24_2567 ENOG4107SQ8 Glycine betaine FORC24_2568 ENOG4108IJ7 Glycine betaine FORC24_2573 ENOG4105E66 phosphoriboisomerase A FORC24_2574 ENOG41082BV acetyltransferase FORC24_2575 ENOG4108M1A Chitin-binding protein FORC24_2581 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FORC24_2582 ENOG4105MSB protein, conserved in bacteria FORC24_2588 ENOG4108Z7F N-acetyltransferase FORC24_2592 ENOG4105EEM helicase FORC24_2596 ENOG4105C9U ATP-dependent DNA helicase RecQ FORC24_2601 ENOG4105DQ6 Transposase FORC24_2608 ENOG4108M1A Chitin-binding protein FORC24_2612 ENOG4105BZG amino acid carrier protein FORC24_2613 ENOG4105C26 Dehydrogenase FORC24_2614 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FORC24_2615 ENOG4105CTU Proline racemase FORC24_2616 ENOG4105CTU Proline racemase FORC24_2617 ENOG41080HI glycine oxidase FORC24_2619 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FORC24_2626 ENOG4105DCI Phosphohydrolase FORC24_2627 ENOG4107T5V SNARE associated Golgi FORC24_2629 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FORC24_2633 ENOG4105DTQ mandelate racemase muconate lactonizing FORC24_2636 ENOG4107SET aldo keto reductase FORC24_2643 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FORC24_2644 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC24_2645 ENOG4105BZU Histidine kinase FORC24_2646 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC24_2654 ENOG4105DPN Oligoendopeptidase f FORC24_2655 ENOG4105EPR degv family FORC24_2667 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FORC24_2668 ENOG4106K7D Major facilitator family transporter FORC24_2671 ENOG4107BMA Transglycosylase associated protein FORC24_2674 ENOG41089UC methyltransferase, type 11 FORC24_2681 ENOG4105CHM Aminotransferase FORC24_2687 ENOG4105DVE abc transporter atp-binding protein FORC24_2691 ENOG4105C02 permease FORC24_2693 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FORC24_2694 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FORC24_2695 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FORC24_2696 ENOG4105D7T ABC transporter FORC24_2703 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FORC24_2710 ENOG4107VC0 DNA alkylation repair enzyme FORC24_2711 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FORC24_2713 ENOG4107VMI polysaccharide deacetylase FORC24_2715 ENOG4108ZCF integral membrane protein FORC24_2716 ENOG4105E0M Sulfatase FORC24_2717 ENOG4105C5H ABC transporter FORC24_2719 ENOG4105EYF MMPL domain protein FORC24_2720 ENOG41082JN Transcriptional regulator FORC24_2724 ENOG4105CIH Imidazole acetol-phosphate transaminase FORC24_2725 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FORC24_2726 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FORC24_2736 ENOG41069ER domain protein FORC24_2738 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FORC24_2744 ENOG4105D4B ABC, transporter FORC24_2745 ENOG4105F5R ABC transporter FORC24_2746 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FORC24_2748 ENOG4105DKT Transcriptional regulator FORC24_2749 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) FORC24_2751 ENOG41061GT Aldolase FORC24_2753 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FORC24_2760 ENOG4105II7 pyrroline-5-carboxylate reductase FORC24_2762 ENOG4107258 Transcriptional regulator FORC24_2765 ENOG4105ECK Fatty Acid Desaturase FORC24_2767 ENOG4107RBI VanW family FORC24_2768 ENOG4105G6Z alkaline phosphatase FORC24_2770 ENOG4105VMP Transcriptional regulator FORC24_2774 ENOG41068WN FORC24_2780 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FORC24_2785 ENOG4105CKK Glycosyl transferase, family 2 FORC24_2791 ENOG4105C8Y Acetylornithine aminotransferase FORC24_2800 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FORC24_2809 ENOG4108IBT Inherit from COG: transposase FORC24_2813 ENOG4108TVJ Nitroreductase FORC24_2814 ENOG4105FS7 Transcriptional regulator FORC24_2817 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FORC24_2822 ENOG4108DMH HTH_ARAC FORC24_2823 ENOG4108FWV Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FORC24_2824 ENOG4108XET gCN5-related N-acetyltransferase FORC24_2827 ENOG4108PCN EamA-like transporter family FORC24_2831 ENOG4107XJU UPF0178 protein FORC24_2842 ENOG410635A Membrane FORC24_2844 ENOG4108IQI permease FORC24_2846 ENOG4105F1N DNA alkylation repair FORC24_2852 ENOG4107RF6 penicillin-binding protein FORC24_2854 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FORC24_2858 ENOG4105E7W lamb ycsf family protein FORC24_2860 ENOG4105P4J Allophanate hydrolase, subunit 1 FORC24_2861 ENOG4107258 Transcriptional regulator FORC24_2863 ENOG4106N3A copper homeostasis protein cutc FORC24_2864 ENOG4108ZHR arsR family transcriptional regulator FORC24_2866 ENOG4105FDT acyl-CoA dehydrogenase FORC24_2869 ENOG4105DWD nucleoside recognition domain protein FORC24_2878 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FORC24_2883 ENOG4105E2A Dehydrogenase FORC24_2884 ENOG4108IJ0 Aspartate ammonia-lyase FORC24_2885 ENOG4105HDK L-asparaginase FORC24_2886 ENOG4108IMY Transcriptional regulator FORC24_2888 ENOG4108B31 Spore germination protein FORC24_2890 ENOG4105BZU Histidine kinase FORC24_2896 ENOG41075H3 AraC family transcriptional regulator FORC24_2898 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FORC24_2899 ENOG4105CUB amino acid FORC24_2900 ENOG4105II7 pyrroline-5-carboxylate reductase FORC24_2901 ENOG4108NHD germination protein FORC24_2902 ENOG4108Q8B Spore germination protein FORC24_2909 ENOG4106A3M Cytochrome p-450 FORC24_2912 ENOG4105CGH 5'-nucleotidase FORC24_2914 ENOG4105CHJ isochorismatase hydrolase FORC24_2919 ENOG41090MY MarR family Transcriptional regulator FORC24_2924 ENOG4105F6J Alpha beta hydrolase fold FORC24_2927 ENOG4108606 TspO/MBR family FORC24_2928 ENOG4105CVP deoxyribo-dipyrimidine photolyase FORC24_2933 ENOG4108TWJ NADH dehydrogenase subunit 5 FORC24_2934 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FORC24_2937 ENOG4105E1K spore germination protein FORC24_2938 ENOG4107VMI polysaccharide deacetylase FORC24_2939 ENOG4105KY5 gCN5-related N-acetyltransferase FORC24_2940 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FORC24_2943 ENOG4105Z7P Acetyltransferase (GNAT) family FORC24_2945 ENOG4105D6J arsenicaL-resistance protein FORC24_2946 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FORC24_2947 ENOG41085FC arsR family transcriptional regulator FORC24_2949 ENOG4105NAE bifunctional deaminase-reductase domain protein FORC24_2953 ENOG4107P5I polyketide synthase FORC24_2954 ENOG4108IG5 Transcriptional regulator FORC24_2955 ENOG4105CHR reductase FORC24_2956 ENOG4108YXU transcriptional regulator AsnC family FORC24_2981 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC24_2982 ENOG41062D9 Histidine kinase FORC24_2991 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FORC24_2992 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC24_2995 ENOG4105K6H D-cysteine desulfhydrase FORC24_2998 ENOG4105JQZ Methyltransferase FORC24_3002 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FORC24_3006 ENOG4105BZU Histidine kinase FORC24_3008 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FORC24_3010 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FORC24_3018 ENOG4105C44 Serine transporter FORC24_3019 ENOG4105EJQ L-serine dehydratase FORC24_3021 ENOG4108JPW Aminotransferase FORC24_3024 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FORC24_3026 ENOG4105DVH amino acid FORC24_3030 ENOG4108JQ1 Dehydrogenase FORC24_3031 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FORC24_3034 ENOG41082W1 Cupin 2, conserved barrel domain protein FORC24_3035 ENOG410874W AraC family transcriptional regulator FORC24_3039 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FORC24_3103 ENOG4107EV6 Inherit from COG: YD repeat protein FORC24_3108 ENOG4108VXD carboxy-peptidase FORC24_3109 ENOG4105PNM synthesis protein FORC24_3110 ENOG4108ISG Major Facilitator FORC24_3113 ENOG4107MII Sugar-specific transcriptional regulator TrmB FORC24_3114 ENOG4105CZM Major Facilitator FORC24_3116 ENOG4105CRW Short chain fatty acid transporter FORC24_3118 ENOG4105DYS nad(p)h dehydrogenase (quinone) FORC24_3130 ENOG4108K8S endonuclease I FORC24_3133 ENOG4108Z66 YbaK ebsC protein FORC24_3134 ENOG4105CUT histidyl-tRNA synthetase FORC24_3137 ENOG4105KVH Transcriptional regulator FORC24_3138 ENOG4108RCM Nitroreductase FORC24_3144 ENOG4108PSK reductase FORC24_3158 ENOG4105C31 Tryptophanyl-tRNA synthetase FORC24_3159 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FORC24_3165 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) FORC24_3167 ENOG4105EV4 Multidrug resistance protein mdtH FORC24_3173 ENOG4105C37 (CBS) domain FORC24_3176 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FORC24_3177 ENOG4105FAW cDP-glucose 4,6-dehydratase FORC24_3179 ENOG4105C1B dTDP-glucose 4-6-dehydratase FORC24_3184 ENOG4105DDN Pentapeptide repeat-containing protein FORC24_3185 ENOG4105XDF Protein of unknown function (DUF1272) FORC24_3186 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FORC24_3187 ENOG4105CMG Carbohydrate kinase FORC24_3188 ENOG4105C6Z Gluconate FORC24_3191 ENOG4105CV1 Transketolase (EC 2.2.1.1) FORC24_3192 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FORC24_3193 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FORC24_3194 ENOG4105CIS alcohol dehydrogenase FORC24_3195 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FORC24_3197 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FORC24_3200 ENOG4105C8Q Methyl-accepting chemotaxis FORC24_3201 ENOG4108UX3 '-nucleotidase FORC24_3202 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FORC24_3203 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FORC24_3204 ENOG4105KVH Transcriptional regulator FORC24_3207 ENOG4105CV8 reductase FORC24_3208 ENOG4105F27 Major Facilitator FORC24_3210 ENOG41090KN UPF0303 protein FORC24_3212 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FORC24_3213 ENOG4105CHH sulfate transporter FORC24_3216 ENOG4105C44 Serine transporter FORC24_3220 ENOG4105KVH Transcriptional regulator FORC24_3221 ENOG4108TZY GntR Family Transcriptional Regulator FORC24_3222 ENOG4105D9R oxidoreductase FORC24_3223 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FORC24_3224 ENOG4105KVH Transcriptional regulator FORC24_3225 ENOG4105KVH Transcriptional regulator FORC24_3234 ENOG4105JAB phenazine biosynthesis protein, phzf family FORC24_3236 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FORC24_3237 ENOG4105KVH Transcriptional regulator FORC24_3239 ENOG4105DQ6 Transposase FORC24_3241 ENOG4108ZJ4 polysaccharide deacetylase FORC24_3257 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FORC24_3259 ENOG4107YXZ hydrolase, family 25 FORC24_3265 ENOG4105H3G oxidoreductase FORC24_3278 ENOG4108TN2 lmbE family FORC24_3280 ENOG4107R3E Citrate transporter FORC24_3283 ENOG4108MES Periplasmic binding protein FORC24_3284 ENOG4105EHG Permease protein FORC24_3285 ENOG4105DQ5 transport system permease protein FORC24_3286 ENOG4105NX3 Membrane FORC24_3290 ENOG41068WN FORC24_3291 ENOG4107CUJ Protein of unknown function (DUF2690) FORC24_3293 ENOG4107V2S Transcriptional regulator FORC24_3297 ENOG4105C98 muts2 protein FORC24_3299 ENOG4105E5K Alpha-amylase FORC24_3300 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FORC24_3301 ENOG4105DPN Oligoendopeptidase f FORC24_3306 ENOG4105FFC UPF0187 protein FORC24_3309 ENOG4108A04 Beta-lactamase FORC24_3314 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FORC24_3316 ENOG41082BM Transcriptional regulator, arsr family FORC24_3317 ENOG4105CB2 alcohol dehydrogenase FORC24_3322 ENOG4105CQB FAD linked oxidase domain protein FORC24_3329 ENOG4105BZU Histidine kinase FORC24_3331 ENOG4105KT7 mgtC SapB transporter FORC24_3333 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FORC24_3334 ENOG41073R8 VanW family FORC24_3336 ENOG4108R1P FORC24_3340 ENOG4105VEQ Cold shock protein FORC24_3344 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FORC24_3348 ENOG410904N short-chain dehydrogenase reductase FORC24_3350 ENOG4106IQC argininosuccinate lyase FORC24_3353 ENOG4108IA2 Sodium pantothenate symporter FORC24_3355 ENOG4105C26 Dehydrogenase FORC24_3356 ENOG4105CHR reductase FORC24_3358 ENOG4105EWU Squalene--hopene cyclase FORC24_3360 ENOG4105FR1 rard protein FORC24_3361 ENOG410696E Membrane FORC24_3364 ENOG4105D1F ATP-binding protein FORC24_3366 ENOG4108ZAF Molybdopterin FORC24_3367 ENOG4105CVM Molybdenum cofactor synthesis domain protein FORC24_3368 ENOG4105D06 uba thif-type nad fad binding protein FORC24_3369 ENOG4105TMB Formate nitrite transporter FORC24_3371 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FORC24_3372 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FORC24_3374 ENOG4108JB9 formate dehydrogenase FORC24_3375 ENOG4105E1K spore germination protein FORC24_3378 ENOG4105CUB amino acid FORC24_3388 ENOG4107QJT sodium dicarboxylate symporter FORC24_3389 ENOG4108KGH TRANSCRIPTIONal FORC24_3391 ENOG4105EMN RNA polymerase sigma factor FORC24_3393 ENOG4105CIG ABC transporter FORC24_3397 ENOG4105D9R oxidoreductase FORC24_3399 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FORC24_3400 ENOG4105K4P CoA-binding domain protein FORC24_3401 ENOG4105C0H protease FORC24_3402 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC24_3404 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FORC24_3405 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FORC24_3406 ENOG4105W8X HesB YadR YfhF-family protein FORC24_3411 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FORC24_3412 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC24_3415 ENOG4108JJA ABC, transporter FORC24_3416 ENOG4108I0Z Aconitate hydratase FORC24_3423 ENOG4105E5W Transporter FORC24_3425 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FORC24_3429 ENOG4107F3J Amp-dependent synthetase and ligase FORC24_3430 ENOG4107ZYJ bioY protein FORC24_3431 ENOG4105CEY Amp-dependent synthetase and ligase FORC24_3434 ENOG4108IMY Transcriptional regulator FORC24_3441 ENOG4107AYK membrAne FORC24_3444 ENOG4105BZU Histidine kinase FORC24_3445 ENOG4105FBA Phospholipase Carboxylesterase FORC24_3446 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FORC24_3447 ENOG4105CK7 Sodium proline symporter FORC24_3448 ENOG4105CBC glutamate synthase FORC24_3449 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FORC24_3450 ENOG4108VJ1 Transcriptional regulator (CarD family FORC24_3451 ENOG4108903 Formimidoylglutamase FORC24_3453 ENOG4105CGP Urocanate hydratase FORC24_3463 ENOG4107QIV Cytochrome c biogenesis protein FORC24_3465 ENOG4105CH2 amidohydrolase FORC24_3467 ENOG4105CJ1 ABC, transporter FORC24_3470 ENOG4107RSM transcriptional regulator FORC24_3471 ENOG4105VAW lrga family FORC24_3472 ENOG41067MG lrgb family FORC24_3480 ENOG4105BZ1 (ABC) transporter FORC24_3481 ENOG4105BZ1 (ABC) transporter FORC24_3488 ENOG4108HW3 (ABC) transporter FORC24_3489 ENOG4105CGH 5'-nucleotidase FORC24_3491 ENOG4108SVB resolvase FORC24_3496 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis FORC24_3500 ENOG4105E4C Lytic transglycosylase catalytic FORC24_3501 ENOG41065S2 pneumococcal vaccine antigen FORC24_3507 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FORC24_3508 ENOG4105C5F glutamine synthetase FORC24_3509 ENOG4105KV4 Transcriptional regulator FORC24_3510 ENOG4105CXI aluminum resistance protein FORC24_3511 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FORC24_3512 ENOG4105EN6 Membrane FORC24_3513 ENOG4106F1P AAA ATPase, central domain protein FORC24_3519 ENOG41069ER domain protein FORC24_3521 ENOG4105DQ6 Transposase FORC24_3522 ENOG4105DM4 PTS System FORC24_3523 ENOG4105DE4 1-phosphofructokinase FORC24_3524 ENOG4105E98 transcriptional regulator DeoR family FORC24_3525 ENOG4107QW4 alcohol dehydrogenase FORC24_3526 ENOG4108SJC Membrane FORC24_3528 ENOG4105C85 amino acid FORC24_3531 ENOG4105TMB Formate nitrite transporter FORC24_3532 ENOG4105K70 DNA-binding protein FORC24_3534 ENOG4105C59 p-type ATPase FORC24_3535 ENOG410681U heavy metal transport detoxification protein FORC24_3536 ENOG4105VPX protein, conserved in bacteria FORC24_3538 ENOG4105NIV Esterase FORC24_3539 ENOG4105E0A ABC, transporter FORC24_3543 ENOG4105CGK Exodeoxyribonuclease III FORC24_3545 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FORC24_3546 ENOG4105D03 DNA-3-methyladenine glycosylase II FORC24_3547 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FORC24_3551 ENOG4105BZU Histidine kinase FORC24_3559 ENOG41067MG lrgb family FORC24_3562 ENOG4108S3Y transcriptional regulator FORC24_3563 ENOG4105CS2 ec 3.2.1.21 FORC24_3566 ENOG4105F0V Cell wall hydrolase FORC24_3568 ENOG4105E0M Sulfatase FORC24_3569 ENOG410890F Dynamin family FORC24_3575 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FORC24_3576 ENOG4105DQU oxidoreductase, subunit beta FORC24_3577 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FORC24_3578 ENOG4108IGT Dipeptidase FORC24_3579 ENOG4105MCT stage V sporulation protein S FORC24_3580 ENOG4105D48 metallophosphoesterase FORC24_3583 ENOG4105CEV competence damage-inducible protein FORC24_3584 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FORC24_3587 ENOG4105XZV Protein of unknown function (DUF3243) FORC24_3588 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FORC24_3592 ENOG4105UIB (ABC) transporter FORC24_3593 ENOG4108JQ9 ABC transporter FORC24_3594 ENOG4105DIH basic membrane FORC24_3595 ENOG4105FDP GntR family transcriptional regulator FORC24_3596 ENOG4105CNU cell division protein FtsK FORC24_3598 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FORC24_3600 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FORC24_3602 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FORC24_3603 ENOG4108S0H Dipicolinic acid synthetase, b subunit FORC24_3604 ENOG4105E35 Dipicolinate synthase subunit A FORC24_3606 ENOG4105C1V Peptidase, M16 FORC24_3610 ENOG4105DTN riboflavin biosynthesis protein ribF FORC24_3613 ENOG4105W7A Protein of unknown function (DUF503) FORC24_3615 ENOG4105VHM ribosomal protein FORC24_3616 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FORC24_3617 ENOG4105CHV Transcription elongation factor NusA FORC24_3619 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FORC24_3621 ENOG4105DZP Membrane-associated zinc metalloprotease FORC24_3622 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FORC24_3623 ENOG4105KNE Phosphatidate cytidylyltransferase FORC24_3624 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FORC24_3626 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FORC24_3632 ENOG4108HE4 integrase family FORC24_3633 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) FORC24_3634 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FORC24_3635 ENOG4105C79 DNA protecting protein DprA FORC24_3636 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FORC24_3639 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FORC24_3644 ENOG4105VB6 UPF0109 protein FORC24_3648 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FORC24_3649 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FORC24_3652 ENOG4105CHR reductase FORC24_3653 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FORC24_3656 ENOG4105CB5 ATP-dependent DNA helicase recG FORC24_3657 ENOG4105DP4 dak2 domain fusion protein ylov FORC24_3658 ENOG4108ZAA Alkaline-shock protein FORC24_3660 ENOG4105FJ0 thiamine FORC24_3661 ENOG4105DJV ribulose-phosphate 3-epimerase FORC24_3662 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FORC24_3663 ENOG4105D9P serine threonine protein kinase FORC24_3664 ENOG4108ZF3 Phosphatase FORC24_3665 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FORC24_3666 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FORC24_3669 ENOG4105C25 Primosomal protein n' FORC24_3670 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FORC24_3674 ENOG4105DSJ YicC domain protein FORC24_3676 ENOG4105F23 Fibronectin-binding protein FORC24_3677 ENOG4105DC7 peptidase M24 FORC24_3681 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FORC24_3684 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) FORC24_3685 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FORC24_3687 ENOG4105CD3 dihydroorotase FORC24_3691 ENOG4105C34 Pseudouridine synthase FORC24_3694 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FORC24_3696 ENOG4105DBK s4 domain protein FORC24_3697 ENOG41067XK integral membrane protein FORC24_3699 ENOG4105DFA alanine racemase domain protein FORC24_3700 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FORC24_3701 ENOG4105WR5 sporulation protein, YlmC YmxH family FORC24_3703 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC24_3705 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FORC24_3706 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FORC24_3708 ENOG4105D4A Cell wall formation (By similarity) FORC24_3709 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FORC24_3710 ENOG4105CNI cell division protein FtsW FORC24_3711 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FORC24_3713 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FORC24_3714 ENOG4105CJN penicillin-binding protein FORC24_3715 ENOG4105CJN penicillin-binding protein FORC24_3718 ENOG41074B2 UPF0747 protein FORC24_3723 ENOG4105KNH Nucleic acid-binding protein FORC24_3725 ENOG41063PX domain protein FORC24_3726 ENOG4105D78 K07001 NTE family protein FORC24_3727 ENOG4105H20 Sporulation integral membrane protein YlbJ FORC24_3729 ENOG4106H78 methyltransferase FORC24_3733 ENOG4107TB6 phosphoglycerate mutase FORC24_3736 ENOG4106UY4 Inherit from COG: Scp-like extracellular FORC24_3745 ENOG4107VFP cytochrome oxidase assembly FORC24_3746 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FORC24_3747 ENOG4105CNI cell division protein FtsW FORC24_3750 ENOG4108IAB Phoh family FORC24_3754 ENOG4105QA2 FORC24_3755 ENOG4105CI3 gtp-binding protein typa FORC24_3757 ENOG4105ECY inositol monophosphatase FORC24_3761 ENOG4105CXN decarboxylase FORC24_3771 ENOG4105CPP Dehydrogenase, E1 component FORC24_3774 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FORC24_3775 ENOG4108X4Q Hydrolase FORC24_3777 ENOG4105CN5 Metallo-Beta-Lactamase FORC24_3778 ENOG4107ZYR domain protein FORC24_3785 ENOG4108XRC Protein of unknown function (DUF458) FORC24_3787 ENOG4107IN1 Protein of unknown function (DUF1797) FORC24_3791 ENOG4105EPM Diguanylate phosphodiesterase FORC24_3792 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FORC24_3795 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FORC24_3797 ENOG4105UIN FORC24_3805 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FORC24_3808 ENOG4105EKQ RNA-directed DNA polymerase FORC24_3811 ENOG4108HGU Histidine kinase FORC24_3813 ENOG4105CHM Aminotransferase FORC24_3814 ENOG4105FKQ transcriptional regulator FORC24_3815 ENOG4105EG2 ABC transporter, permease FORC24_3817 ENOG4107FKK extracellular solute-binding protein family 1 FORC24_3819 ENOG4105CG3 alpha amylase, catalytic region FORC24_3827 ENOG4105CHU acetyl-coa acetyltransferase FORC24_3833 ENOG4105K7K Transcriptional regulator FORC24_3834 ENOG4105DTD Dehydrogenase FORC24_3838 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FORC24_3840 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate FORC24_3843 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FORC24_3846 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FORC24_3848 ENOG4105BZU Histidine kinase FORC24_3852 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FORC24_3855 ENOG4105CID antiterminator FORC24_3857 ENOG4105FDP GntR family transcriptional regulator FORC24_3859 ENOG4105CE4 GlcNAc 6-P deacetylase FORC24_3865 ENOG4107ZE5 PPIases accelerate the folding of proteins FORC24_3866 ENOG4105PTM secreted protein FORC24_3867 ENOG4105J7I hydrolase FORC24_3869 ENOG4105G6R Stage v sporulation protein ae FORC24_3871 ENOG4105CZ3 stage V sporulation protein ad FORC24_3872 ENOG41090VF Stage v sporulation protein ac FORC24_3875 ENOG4105C8J )-transporter FORC24_3876 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC24_3878 ENOG41082AN stage II sporulation protein FORC24_3879 ENOG4105DZ1 carboxypeptidase FORC24_3880 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FORC24_3881 ENOG4105DVE abc transporter atp-binding protein FORC24_3888 ENOG4105D7N magnesium and cobalt transport protein CorA FORC24_3893 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FORC24_3895 ENOG4105I3K Ferric uptake regulator, Fur family FORC24_3896 ENOG4105MZ9 stage II sporulation protein m FORC24_3899 ENOG4105CPC Aldo Keto reductase FORC24_3901 ENOG4105RHY Pfam:UPF0157 FORC24_3905 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FORC24_3907 ENOG4105ETE Transcriptional regulator (LacI family FORC24_3908 ENOG4108YM7 Gcn5-related n-acetyltransferase FORC24_3912 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FORC24_3913 ENOG4108R6K riboflavin synthase, subunit alpha FORC24_3918 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FORC24_3919 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FORC24_3922 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FORC24_3924 ENOG4105DFD Na H antiporter FORC24_3925 ENOG4105CGH 5'-nucleotidase FORC24_3930 ENOG4105DBV ornithine carbamoyltransferase FORC24_3933 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FORC24_3936 ENOG4108IXY short-chain dehydrogenase reductase FORC24_3937 ENOG41069FQ Metallo-beta-lactamase superfamily FORC24_3938 ENOG4105II7 pyrroline-5-carboxylate reductase FORC24_3939 ENOG4105EJQ L-serine dehydratase FORC24_3942 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FORC24_3945 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FORC24_3946 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FORC24_3949 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FORC24_3950 ENOG4105D9U N-acetyltransferase FORC24_3952 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FORC24_3953 ENOG4108QEG Membrane FORC24_3954 ENOG4105CDA abc transporter atp-binding protein FORC24_3955 ENOG4105E5Q amino acid AbC transporter FORC24_3956 ENOG4108HW3 (ABC) transporter FORC24_3958 ENOG4105G7B Protein of unknown function (DUF2992) FORC24_3960 ENOG4108QY0 Membrane FORC24_3962 ENOG4105C7S Dehydrogenase FORC24_3963 ENOG4105CPP Dehydrogenase, E1 component FORC24_3966 ENOG4105CKM Branched-chain carboxylic acid kinase FORC24_3967 ENOG4107RDP Dehydrogenase FORC24_3970 ENOG4108JUB Transcriptional regulator FORC24_3972 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FORC24_3976 ENOG4107QQR Sporulation FORC24_3977 ENOG4105S1Z Stage IV sporulation protein B FORC24_3978 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FORC24_3979 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FORC24_3980 ENOG4105DX0 Hemolysin A FORC24_3982 ENOG4105CTB Polyprenyl synthetase FORC24_3985 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FORC24_3987 ENOG4108ZSR alkaline shock protein FORC24_3988 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FORC24_3992 ENOG410644B Stage III sporulation protein af FORC24_3994 ENOG4105KQ4 Stage iii sporulation protein ad FORC24_3995 ENOG4108CQH stage III sporulation protein AC FORC24_3996 ENOG4105KR5 Stage iii sporulation protein FORC24_3997 ENOG4105CD2 stage iii sporulation protein aa FORC24_4001 ENOG4105DC7 peptidase M24 FORC24_4002 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FORC24_4004 ENOG4105CBJ Metal-dependent enzyme FORC24_4006 ENOG4107YBY Hydrolase FORC24_4012 ENOG41082GG biotin lipoate A B protein ligase FORC24_4013 ENOG4105WZW rhodanese family FORC24_4018 ENOG41080TC multidrug resistance protein FORC24_4025 ENOG4105CJ1 ABC, transporter FORC24_4026 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FORC24_4032 ENOG4105C0D helicase FORC24_4050 ENOG4107R6U sodium dicarboxylate symporter FORC24_4057 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FORC24_4058 ENOG4105C3R Methionine synthase FORC24_4060 ENOG4105C28 cystathionine FORC24_4061 ENOG4105C28 cystathionine FORC24_4065 ENOG4105C5X domain protein FORC24_4067 ENOG4105DKQ ROK family FORC24_4069 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FORC24_4072 ENOG4108UTW Plays a role in the regulation of phosphate uptake FORC24_4073 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FORC24_4074 ENOG4105C8U phosphate abc transporter FORC24_4075 ENOG4105C8U phosphate abc transporter FORC24_4076 ENOG4105EXS phosphate abc transporter FORC24_4077 ENOG4107RF6 penicillin-binding protein FORC24_4079 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FORC24_4083 ENOG4105N80 Ferric uptake regulator, Fur family FORC24_4085 ENOG4105FDK ABC transporter FORC24_4086 ENOG4108JYZ YitT family FORC24_4087 ENOG41069ZM Protein of unknown function (DUF2624) FORC24_4092 ENOG4105EGD dinuclear metal center protein, YbgI family FORC24_4095 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC24_4096 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FORC24_4100 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FORC24_4101 ENOG4105KG3 cytidine deaminase FORC24_4102 ENOG4107YR5 Diacylglycerol kinase FORC24_4103 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FORC24_4104 ENOG4105CTJ Metal Dependent Phosphohydrolase FORC24_4105 ENOG4105C9A Phoh family FORC24_4107 ENOG41068P3 sporulation protein YqfC FORC24_4109 ENOG4105KTH gatB Yqey FORC24_4111 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FORC24_4112 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FORC24_4118 ENOG4105CSA Coproporphyrinogen iii oxidase FORC24_4119 ENOG4105KVH Transcriptional regulator FORC24_4124 ENOG4105TQK DNA polymerase iii, delta' subunit FORC24_4125 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FORC24_4126 ENOG4108UK2 deaminase FORC24_4127 ENOG4105KQC Competence protein FORC24_4129 ENOG4105DXX methyltransferase FORC24_4131 ENOG4108WF2 Metal Dependent Phosphohydrolase FORC24_4133 ENOG410812S Rna-binding protein FORC24_4135 ENOG4105CQW ribosome biogenesis GTPase YqeH FORC24_4136 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FORC24_4139 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC24_4143 ENOG4108TVJ Nitroreductase FORC24_4146 ENOG4105G6Z alkaline phosphatase FORC24_4147 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FORC24_4148 ENOG4108MUZ hydrolase FORC24_4154 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FORC24_4155 ENOG4105MIR Phenylalanine 4-monooxygenase FORC24_4157 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FORC24_4165 ENOG4105S6R Iron-hydroxamate transporter permease subunit FORC24_4166 ENOG4108V5C ABC transporter FORC24_4168 ENOG4108EKI Dehydrogenase FORC24_4169 ENOG4105C28 cystathionine FORC24_4175 ENOG4107XRG penicillin-binding protein FORC24_4177 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FORC24_4179 ENOG4105CFP Peptidase U32 FORC24_4180 ENOG4105XYU peptidase (U32 family) FORC24_4181 ENOG4108VQJ O-methyltransferase FORC24_4182 ENOG4105HHA aminodeoxychorismate lyase FORC24_4186 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FORC24_4188 ENOG4105C02 permease FORC24_4190 ENOG41060CR FORC24_4191 ENOG4105C7H Helicase, RecD TraA family FORC24_4193 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FORC24_4194 ENOG4105C3J Cysteine desulfurase FORC24_4196 ENOG4105D1H recombination factor protein RarA FORC24_4197 ENOG4108VCI transcription factor, rsfa family FORC24_4198 ENOG4105CUZ uba thif-type nad fad binding protein FORC24_4200 ENOG4105CUT histidyl-tRNA synthetase FORC24_4202 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FORC24_4203 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FORC24_4205 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FORC24_4206 ENOG41076HS cation diffusion facilitator family transporter FORC24_4207 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FORC24_4209 ENOG4105CKP Polysaccharide Biosynthesis Protein FORC24_4210 ENOG4108QG2 Membrane FORC24_4212 ENOG4105VIE preprotein translocase, subunit YajC FORC24_4215 ENOG41061AI Protein of unknown function (DUF2905) FORC24_4218 ENOG4108HUF Transporter FORC24_4223 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FORC24_4224 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FORC24_4225 ENOG4108IYU L-aspartate oxidase FORC24_4228 ENOG4108RPX mosc domain containing protein FORC24_4229 ENOG4105CQC Prephenate dehydratase FORC24_4232 ENOG4105C19 ABC transporter FORC24_4233 ENOG4105EWM Histidine kinase FORC24_4235 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FORC24_4238 ENOG4105X36 (ribosomal) protein FORC24_4240 ENOG4105C03 ribonuclease FORC24_4243 ENOG4107QMS site-determining protein FORC24_4246 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FORC24_4247 ENOG4105DFF Rod shape-determining protein mreb FORC24_4251 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FORC24_4252 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FORC24_4254 ENOG41068KH stage VI sporulation protein D FORC24_4256 ENOG4105D52 delta-aminolevulinic acid dehydratase FORC24_4261 ENOG4105K56 Transcriptional regulator FORC24_4265 ENOG4108IUQ atp-dependent protease FORC24_4272 ENOG4108QCI YvbH-like oligomerisation region FORC24_4274 ENOG4105M59 Phosphodiesterase, mj0936 family FORC24_4275 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FORC24_4277 ENOG4108XJQ germination protein FORC24_4280 ENOG4108PCX Major Facilitator FORC24_4282 ENOG4105KBX Transcriptional regulator, TetR family FORC24_4287 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FORC24_4294 ENOG4107XZC Restriction modification system DNA (Specificity FORC24_4296 ENOG4107SCJ type I restriction enzyme EcoKI subunit R FORC24_4297 ENOG4107UNZ domain protein FORC24_4303 ENOG4105PFC Transcriptional regulator FORC24_4306 ENOG4105DZC cytosine deaminase FORC24_4307 ENOG41067S9 phage shock protein C, PspC FORC24_4308 ENOG4108JCI Transcriptional regulator FORC24_4310 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FORC24_4311 ENOG4108Z40 Transcriptional regulator FORC24_4312 ENOG4105RHA ABC transporter, permease FORC24_4313 ENOG4108IUX (ABC) transporter FORC24_4314 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FORC24_4315 ENOG4105ER2 Ompa motb domain protein FORC24_4316 ENOG4105E14 MotA TolQ exbB proton channel FORC24_4317 ENOG4108VXD carboxy-peptidase FORC24_4319 ENOG4105E33 succinate dehydrogenase FORC24_4321 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FORC24_4323 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FORC24_4324 ENOG4105K63 Thioredoxin FORC24_4325 ENOG4105C10 Electron transfer flavoprotein FORC24_4326 ENOG4105BZJ Electron transfer flavoprotein FORC24_4327 ENOG41060WC Enoyl-CoA hydratase FORC24_4328 ENOG4107Z3H Transcriptional regulator, TetR family FORC24_4329 ENOG4105CEY Amp-dependent synthetase and ligase FORC24_4331 ENOG4105J76 Periplasmic binding protein FORC24_4332 ENOG4105S6R Iron-hydroxamate transporter permease subunit FORC24_4342 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC24_4345 ENOG4105DR4 Methyltransferase FORC24_4347 ENOG4105KFN sortase, SrtB family FORC24_4348 ENOG4105E0A ABC, transporter FORC24_4351 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FORC24_4353 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FORC24_4355 ENOG4105FE9 pseudouridine synthase FORC24_4357 ENOG4105DCG PHP domain protein FORC24_4360 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FORC24_4363 ENOG4105C5S asparaginyl-tRNA synthetase FORC24_4364 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FORC24_4366 ENOG4108RWN rrna methyltransferase FORC24_4372 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC24_4373 ENOG4105CW7 secretion protein, HlyD family FORC24_4374 ENOG4108JGH Tetr family transcriptional regulator FORC24_4375 ENOG4105CN9 Peptidase m42 family protein FORC24_4379 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FORC24_4380 ENOG4105C22 threonyL-tRNA synthetase FORC24_4381 ENOG4108TDW sporulation protein YtxC FORC24_4386 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FORC24_4387 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FORC24_4388 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FORC24_4390 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FORC24_4391 ENOG4105C2M dna polymerase I FORC24_4392 ENOG4105BZU Histidine kinase FORC24_4393 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC24_4396 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FORC24_4397 ENOG4108HMX isocitrate dehydrogenase (NADP) FORC24_4398 ENOG4105BZN citrate synthase FORC24_4400 ENOG4108REF Sporulation integral membrane protein ytvi FORC24_4401 ENOG4105FS0 cytoplasmic membrane protein FORC24_4406 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FORC24_4407 ENOG4105C6K Malic enzyme FORC24_4408 ENOG4105C0B DNA polymerase III (alpha subunit) FORC24_4409 ENOG4105VV2 FORC24_4411 ENOG4105SFS phosphoesterase RecJ domain protein FORC24_4416 ENOG4105E8R UPF0173 metal-dependent hydrolase FORC24_4417 ENOG4105DC7 peptidase M24 FORC24_4424 ENOG4105Z7P Acetyltransferase (GNAT) family FORC24_4425 ENOG41082W1 Cupin 2, conserved barrel domain protein FORC24_4429 ENOG4107YZX Universal stress protein FORC24_4433 ENOG4105CH7 arginosuccinase FORC24_4437 ENOG4108JYZ YitT family FORC24_4441 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FORC24_4443 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FORC24_4444 ENOG4105KBJ sporulation protein ytfj FORC24_4447 ENOG4105EFZ amidohydrolase FORC24_4449 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FORC24_4454 ENOG4106KR7 LysR family Transcriptional regulator FORC24_4456 ENOG4105U5Y Transcriptional regulator FORC24_4458 ENOG4105C28 cystathionine FORC24_4464 ENOG4105EMN RNA polymerase sigma factor FORC24_4466 ENOG4108UW5 maltose o-acetyltransferase FORC24_4468 ENOG4105F1V Acetoin utilization protein FORC24_4469 ENOG4105W87 Cbs domain FORC24_4470 ENOG4105DGU Histone deacetylase FORC24_4473 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC24_4475 ENOG4107SNB ankyrin repeat protein YahD FORC24_4476 ENOG4105EP9 oxidoreductase FORC24_4482 ENOG4105ETE Transcriptional regulator (LacI family FORC24_4483 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FORC24_4487 ENOG4105C88 aminopeptidase FORC24_4496 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FORC24_4498 ENOG4108VDD TRNA binding domain protein FORC24_4504 ENOG4105C8F Beta-lactamase domain protein FORC24_4507 ENOG4108V15 phosphotransferase enzyme family FORC24_4508 ENOG4108IUM Glycogen debranching enzyme FORC24_4510 ENOG4107QSE Dipeptidase FORC24_4511 ENOG4105YW5 deoR family transcriptional regulator FORC24_4514 ENOG4105CBX hi0933 family FORC24_4521 ENOG4108VJ1 Transcriptional regulator (CarD family FORC24_4522 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FORC24_4523 ENOG4105CSC Glucose uptake protein FORC24_4526 ENOG4108ZAF Molybdopterin FORC24_4527 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FORC24_4528 ENOG4105CVM Molybdenum cofactor synthesis domain protein FORC24_4530 ENOG4105D06 uba thif-type nad fad binding protein FORC24_4531 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FORC24_4535 ENOG41085GJ domain protein FORC24_4537 ENOG4105DWV Homoserine O-trans-acetylase FORC24_4540 ENOG4108B31 Spore germination protein FORC24_4545 ENOG4105C8T Leucyl-tRNA synthetase FORC24_4546 ENOG410605W Major Facilitator FORC24_4547 ENOG4107S91 Sodium hydrogen exchanger FORC24_4548 ENOG4105NCW Trka-c domain protein FORC24_4551 ENOG4105C19 ABC transporter FORC24_4555 ENOG4105N5T Radical SAM Protein FORC24_4560 ENOG4105E8V Alpha Beta Hydrolase Fold protein FORC24_4561 ENOG4108Z0R Transferase FORC24_4562 ENOG4105YVM Phosphoesterase, PA-phosphatase related FORC24_4563 ENOG4105BZF Glycosyl transferase (Group 1 FORC24_4565 ENOG4108RIR Molybdenum cofactor biosynthesis protein FORC24_4567 ENOG4108MK9 spermidine N(1)-acetyltransferase FORC24_4577 ENOG4105BZU Histidine kinase FORC24_4578 ENOG4105BZU Histidine kinase FORC24_4581 ENOG4107S9D Alpha beta hydrolase FORC24_4582 ENOG4107T7U Sulfatase FORC24_4585 ENOG4105D2X ABC transporter substrate-binding protein FORC24_4587 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FORC24_4599 ENOG4108V2W Carbonate dehydratase FORC24_4600 ENOG4105C4M (Ubiquinol oxidase) subunit I FORC24_4601 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FORC24_4608 ENOG41087YS Phage shock protein A FORC24_4614 ENOG4105BZU Histidine kinase FORC24_4615 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC24_4621 ENOG4108UGV hypoxanthine phosphoribosyltransferase FORC24_4622 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FORC24_4632 ENOG4105C19 ABC transporter FORC24_4634 ENOG4107ZTW SNARE associated Golgi FORC24_4635 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FORC24_4637 ENOG4105C19 ABC transporter FORC24_4638 ENOG41086D8 Transcriptional regulator FORC24_4641 ENOG41082BM Transcriptional regulator, arsr family FORC24_4651 ENOG4105C6Z Gluconate FORC24_4652 ENOG4105FDP GntR family transcriptional regulator FORC24_4656 ENOG41069H0 dihydroorotase EC 3.5.2.3 FORC24_4660 ENOG4105DTQ mandelate racemase muconate lactonizing FORC24_4661 ENOG4105CEY Amp-dependent synthetase and ligase FORC24_4662 ENOG4108IPT Naphthoate synthase FORC24_4663 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FORC24_4664 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FORC24_4665 ENOG4105E4F Isochorismate synthase FORC24_4666 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FORC24_4668 ENOG4105VEQ Cold shock protein FORC24_4677 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FORC24_4680 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FORC24_4681 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FORC24_4682 ENOG4105KT7 mgtC SapB transporter FORC24_4683 ENOG4107PBV potassium channel FORC24_4686 ENOG4105WG9 Conserved Protein FORC24_4688 ENOG4105CHM Aminotransferase FORC24_4689 ENOG4108ZB6 transcriptional regulator AsnC family FORC24_4690 ENOG4105C5I Dehydrogenase FORC24_4691 ENOG4108MUZ hydrolase FORC24_4693 ENOG4105C87 Aminotransferase class I and II FORC24_4696 ENOG4105Y38 Kinase-associated protein B FORC24_4698 ENOG4107R3E Citrate transporter FORC24_4701 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FORC24_4702 ENOG4105KA0 thioesterase Superfamily protein FORC24_4705 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FORC24_4709 ENOG41069ER domain protein FORC24_4712 ENOG4105CEP NADH dehydrogenase FORC24_4718 ENOG4105EWC Purine nucleoside phosphorylase FORC24_4721 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FORC24_4725 ENOG4108JJA ABC, transporter FORC24_4726 ENOG4105C4B ABC transporter, permease FORC24_4727 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FORC24_4733 ENOG41083MR nifu domain-containing protein FORC24_4736 ENOG4108W5N phosphatidylglycerophosphatase a FORC24_4740 ENOG4105DAX Pfam:DUF2983 FORC24_4742 ENOG4105DYS nad(p)h dehydrogenase (quinone) FORC24_4743 ENOG4105D4U had-superfamily hydrolase, subfamily iia FORC24_4746 ENOG4105CBT Fructose-1,6-bisphosphatase FORC24_4749 ENOG4105MMD transcriptional regulator FORC24_4750 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FORC24_4751 ENOG4107TXC Transcriptional regulator FORC24_4752 ENOG41090T1 Membrane FORC24_4757 ENOG4105FAA peptidase M23 FORC24_4758 ENOG4108YTE sporulation protein YunB FORC24_4759 ENOG4105KZD Domain of unknown function (DUF1805) FORC24_4760 ENOG4107R8B 5'-nucleotidase FORC24_4761 ENOG4105DIW FeS assembly protein SUFB FORC24_4762 ENOG4108UNV SUF system FeS assembly protein, NifU family FORC24_4763 ENOG4105C9B Cysteine desulfurase FORC24_4764 ENOG4105JRK feS assembly protein SufD FORC24_4765 ENOG4105C3K feS assembly ATPase SufC FORC24_4766 ENOG4105D01 (LipO)protein FORC24_4767 ENOG4105D01 (LipO)protein FORC24_4768 ENOG4108UMI ABC transporter, permease FORC24_4774 ENOG41080E8 Transcriptional regulator, Spx MgsR family FORC24_4778 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FORC24_4783 ENOG4108W8B Beta-lactamase domain protein FORC24_4784 ENOG4105C1G acyl-Coa dehydrogenase FORC24_4785 ENOG4105CHU acetyl-coa acetyltransferase FORC24_4787 ENOG4105DZ1 carboxypeptidase FORC24_4791 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FORC24_4794 ENOG4108SUT Major Facilitator Superfamily FORC24_4795 ENOG4107R7I amino acid FORC24_4798 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FORC24_4800 ENOG4107AYK membrAne FORC24_4808 ENOG4107ZTW SNARE associated Golgi FORC24_4810 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FORC24_4811 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC24_4812 ENOG4105BZU Histidine kinase FORC24_4815 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FORC24_4818 ENOG4105C8Q Methyl-accepting chemotaxis FORC24_4819 ENOG4105VG1 fes assembly suf system protein FORC24_4820 ENOG4105D4Y metalloprotease FORC24_4821 ENOG4105C2I pirin domain protein FORC24_4824 ENOG4107T5V SNARE associated Golgi FORC24_4825 ENOG4107S91 Sodium hydrogen exchanger FORC24_4826 ENOG4105NCW Trka-c domain protein FORC24_4830 ENOG4108RMU ferritin dps family protein FORC24_4833 ENOG4108URH decarboxylase FORC24_4836 ENOG41090A1 ferritin FORC24_4838 ENOG4105D9N nucleoside FORC24_4839 ENOG4105D9N nucleoside FORC24_4842 ENOG4108RYK Nad-dependent epimerase dehydratase FORC24_4845 ENOG4105CV8 reductase FORC24_4846 ENOG4105F27 Major Facilitator FORC24_4847 ENOG4105KVH Transcriptional regulator FORC24_4850 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FORC24_4851 ENOG4105D4A Cell wall formation (By similarity) FORC24_4853 ENOG4105C8Q Methyl-accepting chemotaxis FORC24_4855 ENOG4105WMR Protein CrcB homolog FORC24_4856 ENOG4105WMR Protein CrcB homolog FORC24_4860 ENOG4105C5H ABC transporter FORC24_4861 ENOG4108MK9 spermidine N(1)-acetyltransferase FORC24_4862 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FORC24_4864 ENOG4108W2Y isochorismatase FORC24_4869 ENOG4108IPW abc transporter atp-binding protein FORC24_4870 ENOG4105CM4 permease protein FORC24_4878 ENOG4105DZR Type I site-specific deoxyribonuclease FORC24_4887 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FORC24_4889 ENOG4105XZU Preprotein translocase, subunit SecG FORC24_4890 ENOG41067MG lrgb family FORC24_4894 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FORC24_4900 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC24_4903 ENOG41090VF Stage v sporulation protein ac FORC24_4904 ENOG4105CZ3 stage V sporulation protein ad FORC24_4907 ENOG4108QY0 Membrane FORC24_4908 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FORC24_4909 ENOG4105KRI phosphocarrier protein (HPr FORC24_4911 ENOG4105CHW UPF0052 protein FORC24_4912 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FORC24_4913 ENOG4108Z4K mutator MutT protein FORC24_4915 ENOG4105C3M thioredoxin reductase FORC24_4917 ENOG4108S4C acetyltransferase FORC24_4919 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) FORC24_4921 ENOG41086DT Membrane protein of unknown function FORC24_4923 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FORC24_4927 ENOG4107TXC Transcriptional regulator FORC24_4930 ENOG4105HMI Membrane FORC24_4931 ENOG4105DUM transcriptional regulator, lysR family FORC24_4933 ENOG4108WS4 fmn reductase FORC24_4936 ENOG4105BZ1 (ABC) transporter FORC24_4938 ENOG4105CN1 protease FORC24_4939 ENOG4105CRP Part of the ABC transporter FtsEX involved in FORC24_4940 ENOG4105CAK Cell division ATP-binding protein ftsE FORC24_4943 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) FORC24_4945 ENOG4105MS2 ribosomal subunit Interface protein FORC24_4946 ENOG4105VEQ Cold shock protein FORC24_4947 ENOG41081UC Inherit from COG: Competence protein FORC24_4950 ENOG4105KVH Transcriptional regulator FORC24_4952 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FORC24_4953 ENOG4108KGH TRANSCRIPTIONal FORC24_4954 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FORC24_4955 ENOG4105C6Y Udp-glucose 6-dehydrogenase FORC24_4956 ENOG4105ESV Glycosyl transferase, family 4 FORC24_4958 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FORC24_4962 ENOG4105F8D glycoside hydrolase family 4 FORC24_4963 ENOG4105VCP PTS System FORC24_4964 ENOG4105CK1 PTS System FORC24_4966 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FORC24_4967 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FORC24_4968 ENOG4105VCP PTS System FORC24_4970 ENOG4105VZJ PTS System FORC24_4974 ENOG4105ECB domain protein FORC24_4975 ENOG4107RSM transcriptional regulator FORC24_4984 ENOG4105DAA L-lactate FORC24_4986 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FORC24_4988 ENOG4105E0M Sulfatase FORC24_4993 ENOG4107R8N Glycosyl transferase, family 2 FORC24_4994 ENOG4105C94 Transporter FORC24_4995 ENOG41069ER domain protein FORC24_5000 ENOG4105KBK Zinc finger, swim domain protein FORC24_5001 ENOG4105C0D helicase FORC24_5007 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC24_5009 ENOG4107RBB ABC transporter, permease FORC24_5010 ENOG4105C19 ABC transporter FORC24_5012 ENOG4105CXY transporter FORC24_5015 ENOG4105BZU Histidine kinase FORC24_5016 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC24_5017 ENOG4105CMR udp-glucose 4-epimerase FORC24_5019 ENOG4108KGH TRANSCRIPTIONal FORC24_5024 ENOG4107T8Q Glycosyl transferase (Group 1 FORC24_5026 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) FORC24_5027 ENOG4105CPF Cell wall formation (By similarity) FORC24_5028 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FORC24_5030 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FORC24_5031 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FORC24_5032 ENOG4107YJ4 chain length determinant protein FORC24_5033 ENOG4105HTX biosynthesis protein FORC24_5034 ENOG4107YJ4 chain length determinant protein FORC24_5037 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FORC24_5038 ENOG4105FRN stage II sporulation protein FORC24_5041 ENOG4105DY9 regulatoR FORC24_5045 ENOG4106778 Protein of unknown function (DUF1146) FORC24_5046 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FORC24_5047 ENOG4105C8S subunit m FORC24_5048 ENOG4105D65 subunit l FORC24_5053 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FORC24_5054 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FORC24_5056 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FORC24_5057 ENOG4105BZU Histidine kinase FORC24_5067 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FORC24_5068 ENOG41062M3 atp synthase FORC24_5071 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FORC24_5072 ENOG4108UIC UPF0340 protein FORC24_5073 ENOG4108YZG isomerase FORC24_5076 ENOG4108VGI doxx family FORC24_5077 ENOG4107XC4 flavin reductase domain protein, FMN-binding FORC24_5081 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FORC24_5083 ENOG4108ZXQ stage ii sporulation protein r FORC24_5084 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FORC24_5085 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FORC24_5086 ENOG4107104 thymidine kinase FORC24_5088 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FORC24_5089 ENOG4105CBT Fructose-1,6-bisphosphatase FORC24_5090 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FORC24_5094 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FORC24_5097 ENOG4105C1G acyl-Coa dehydrogenase FORC24_5098 ENOG4105C1G acyl-Coa dehydrogenase FORC24_5099 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FORC24_5101 ENOG4105DF6 Fe-S oxidoreductase FORC24_5104 ENOG4105BZU Histidine kinase FORC24_5106 ENOG4105D4Y metalloprotease FORC24_5108 ENOG4105BZU Histidine kinase FORC24_5109 ENOG4105KCT ABC transporter FORC24_5110 ENOG4108M15 ABC transporter FORC24_5111 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FORC24_5113 ENOG4105IIU Aminopeptidase FORC24_5117 ENOG4105EMN RNA polymerase sigma factor FORC24_5119 ENOG410684U Domain of unknown function (DUF1934) FORC24_5123 ENOG4105CYW agmatinase FORC24_5125 ENOG4105DXB Major Facilitator superfamily FORC24_5126 ENOG4107SWG transcriptional regulator MERR family FORC24_5127 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FORC24_5128 ENOG4105BZ4 penicillin-binding protein FORC24_5129 ENOG4108XFG YwhD family FORC24_5130 ENOG4108Z4T Peptidase M50 FORC24_5131 ENOG41069HH 4-oxalocrotonate tautomerase FORC24_5132 ENOG4105DCI Phosphohydrolase FORC24_5133 ENOG4108MES Periplasmic binding protein FORC24_5134 ENOG4105E0A ABC, transporter FORC24_5135 ENOG4105EHG Permease protein FORC24_5136 ENOG4105DQ5 transport system permease protein FORC24_5138 ENOG4108VCI transcription factor, rsfa family FORC24_5139 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) FORC24_5140 ENOG4108IJ2 phosphate acetyltransferase FORC24_5141 ENOG4107UEZ chlorite dismutase FORC24_5143 ENOG4108VKI Cell wall hydrolase FORC24_5147 ENOG4107SVH Potassium channel protein FORC24_5149 ENOG410667J hydrolase FORC24_5150 ENOG4105VCH membrane FORC24_5152 ENOG4108TU7 Inherit from COG: (ABC) transporter FORC24_5153 ENOG4105CJ1 ABC, transporter FORC24_5154 ENOG41090WU lipolytic protein G-D-S-L family FORC24_5157 ENOG4105D6E homoserine dehydrogenase FORC24_5158 ENOG4105CVG Homoserine O-transsuccinylase FORC24_5162 ENOG4108Y4K DNA-binding transcriptional activator FORC24_5164 ENOG4105WH1 Two component transcriptional regulator luxr family FORC24_5165 ENOG4105BZU Histidine kinase FORC24_5166 ENOG4105DWF phosphomethylpyrimidine kinase FORC24_5167 ENOG4105BZU Histidine kinase FORC24_5168 ENOG4105VCD cytoplasmic protein FORC24_5169 ENOG4105D22 carbon starvation protein FORC24_5170 ENOG4105DY9 regulatoR FORC24_5171 ENOG41079KZ Major Facilitator Superfamily FORC24_5173 ENOG4105CG5 Glycosyl transferase (Group 1 FORC24_5175 ENOG4105EN6 Membrane FORC24_5176 ENOG4106YBV Methyl-accepting chemotaxis FORC24_5178 ENOG4108S4H thioesterase Superfamily protein FORC24_5179 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) FORC24_5182 ENOG4105K64 Glycosyl transferase, family 2 FORC24_5185 ENOG4105CKK Glycosyl transferase, family 2 FORC24_5186 ENOG4105C5H ABC transporter FORC24_5187 ENOG41067SE Tetr family transcriptional regulator FORC24_5189 ENOG4105E0X reductase FORC24_5190 ENOG4106F5Q Membrane FORC24_5193 ENOG4108NEV two component transcriptional regulator, LytTR family FORC24_5195 ENOG4107RGD Major Facilitator superfamily FORC24_5198 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FORC24_5200 ENOG4105IW1 AmiS UreI transporter FORC24_5201 ENOG4105CMR udp-glucose 4-epimerase FORC24_5202 ENOG4108UT2 hemolysin iii FORC24_5204 ENOG4105C1J atp-dependent rna helicase FORC24_5205 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) FORC24_5206 ENOG4105DPN Oligoendopeptidase f FORC24_5208 ENOG4105BZU Histidine kinase FORC24_5209 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) FORC24_5211 ENOG4105C0H protease FORC24_5212 ENOG4105Q2H domain protein FORC24_5215 ENOG4105BZU Histidine kinase FORC24_5216 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC24_5217 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FORC24_5218 ENOG4105CDU Replicative dna helicase FORC24_5220 ENOG4105BZR domain protein FORC24_5221 ENOG4108XMW Membrane FORC24_5223 ENOG4108UUM single-stranded DNA-binding protein FORC24_5225 ENOG4105C3G gtp-binding protein FORC24_5226 ENOG4105VDK protein, conserved in bacteria FORC24_5227 ENOG4105D8X mechanosensitive ion channel FORC24_5228 ENOG4108ZDA Sporulation protein YyaC FORC24_5229 ENOG4105FA0 parb-like partition protein FORC24_5230 ENOG4107QJE Chromosome Partitioning Protein FORC24_5233 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FORC24_5234 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FORC24_5236 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FORC24_t100 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation