locus-tag class description FORC47_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FORC47_0003 ENOG410848D S4 domain protein YaaA FORC47_0006 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FORC47_0008 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FORC47_0014 ENOG4105ZMH deoxynucleoside kinase FORC47_0016 ENOG4105GTG Isochorismatase FORC47_0017 ENOG4108Z6B deaminase FORC47_0018 ENOG4105C6E dna polymerase iii FORC47_0022 ENOG41067KS pro-sigma K processing FORC47_0024 ENOG4105CXN decarboxylase FORC47_0026 ENOG4105FA2 dna polymerase iii FORC47_0027 ENOG4105MA4 psp1 domain protein FORC47_0029 ENOG41060K3 Methyltransferase FORC47_0030 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FORC47_0031 ENOG4105KRN Transcriptional regulator, abrb family FORC47_0032 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FORC47_0033 ENOG4105F8V Hydrolase, tatD family FORC47_0034 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FORC47_0036 ENOG4105XFA sporulation peptidase YabG FORC47_0037 ENOG4105W42 Veg protein FORC47_0040 ENOG4105DFT pur operon repressor FORC47_0041 ENOG4105KME endoribonuclease L-psp FORC47_0044 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FORC47_0045 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FORC47_0047 ENOG4108JA2 transcriptioN-repair coupling factor FORC47_0048 ENOG4108M14 stage v sporulation protein t FORC47_0050 ENOG4108IY2 MazG family FORC47_0051 ENOG41082I2 s4 domain protein FORC47_0052 ENOG4105VYY sporulation protein yabp FORC47_0055 ENOG41060GV RNA binding s1 domain protein FORC47_0057 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FORC47_0058 ENOG4108UGV hypoxanthine phosphoribosyltransferase FORC47_0059 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FORC47_0062 ENOG4105C6T cysteine synthase FORC47_0063 ENOG4105CRQ synthase (Component I) FORC47_0064 ENOG4105DDQ anthranilate synthase FORC47_0065 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FORC47_0066 ENOG4105EEI dihydropteroate synthase FORC47_0067 ENOG4105KRF dihydroneopterin aldolase FORC47_0068 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FORC47_0070 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FORC47_0073 ENOG4108Z0C Uvrb UvrC protein FORC47_0076 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FORC47_0078 ENOG4105CTP PilT protein domain protein FORC47_0082 ENOG4105D7W serine acetyltransferase FORC47_0085 ENOG4105C2N RNA methyltransferase TrmH family group 3 FORC47_0086 ENOG4105M0M Tetracycline resistance protein FORC47_0087 ENOG4105QIV RNA polymerase FORC47_0089 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FORC47_0093 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FORC47_0094 ENOG4107Y49 methyltransferase FORC47_0096 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FORC47_0097 ENOG4105XPM ribosomal protein FORC47_0119 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FORC47_0124 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FORC47_0126 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FORC47_0132 ENOG4108JJB ABC transporter FORC47_0133 ENOG4108JJB ABC transporter FORC47_0134 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FORC47_0135 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FORC47_0140 ENOG4105D1F ATP-binding protein FORC47_0143 ENOG4108NMV polysaccharide deacetylase FORC47_0147 ENOG4105C8B TIGR00159 family FORC47_0148 ENOG4107U5W ybbr family FORC47_0151 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FORC47_0155 ENOG4108PSK reductase FORC47_0156 ENOG4108UMI ABC transporter, permease FORC47_0157 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FORC47_0158 ENOG4105D01 (LipO)protein FORC47_0159 ENOG4105CB2 alcohol dehydrogenase FORC47_0161 ENOG4105IQ5 FAD linked oxidase domain protein FORC47_0164 ENOG4105C2C drug resistance transporter, Bcr CflA FORC47_0168 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FORC47_0169 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC47_0170 ENOG4108JQ7 (ABC) transporter FORC47_0174 ENOG4108J59 Extracellular solute-binding protein, family 5 FORC47_0175 ENOG4108J59 Extracellular solute-binding protein, family 5 FORC47_0178 ENOG4106Z1T Nicotinamide Mononucleotide Transporter FORC47_0180 ENOG4105E0C molybdate abc transporter FORC47_0181 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FORC47_0182 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FORC47_0187 ENOG4105F6E Acyl-transferase FORC47_0190 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FORC47_0193 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FORC47_0197 ENOG4105C5H ABC transporter FORC47_0199 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FORC47_0201 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC47_0202 ENOG4105C3U ABC transporter FORC47_0203 ENOG4108JQ7 (ABC) transporter FORC47_0204 ENOG410667J hydrolase FORC47_0205 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FORC47_0206 ENOG4105ERH Fumarylacetoacetate hydrolase FORC47_0208 ENOG4105CUB amino acid FORC47_0209 ENOG4108SC4 )-transporter FORC47_0210 ENOG4105CPF Cell wall formation (By similarity) FORC47_0211 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FORC47_0216 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FORC47_0217 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FORC47_0218 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FORC47_0221 ENOG4105K8N protein family UPF0079, ATPase FORC47_0222 ENOG41072GX Peptidase M22 Glycoprotease FORC47_0223 ENOG410801F ribosomal-protein-alanine acetyltransferase FORC47_0224 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FORC47_0225 ENOG4105C5H ABC transporter FORC47_0228 ENOG4108TYN CAAX amino terminal protease family protein FORC47_0231 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FORC47_0233 ENOG4105C7N Xanthine uracil vitamin C permease FORC47_0235 ENOG4105BZU Histidine kinase FORC47_0237 ENOG4107ZXU DSBA oxidoreductase FORC47_0238 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC47_0244 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) FORC47_0247 ENOG4105SX7 Transporter FORC47_0250 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FORC47_0251 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FORC47_0252 ENOG4105C83 adenylosuccinate lyase FORC47_0257 ENOG4108V3E phosphoribosylglycinamide formyltransferase FORC47_0259 ENOG4105C12 Phosphoribosylglycinamide synthetase FORC47_0261 ENOG4105EGI Transcriptional regulator FORC47_0266 ENOG4105C4R Atp-dependent dna helicase FORC47_0267 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FORC47_0271 ENOG4108W2Y isochorismatase FORC47_0273 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FORC47_0274 ENOG4108UMI ABC transporter, permease FORC47_0275 ENOG4105D01 (LipO)protein FORC47_0279 ENOG410834F Transcriptional regulator FORC47_0280 ENOG4107I77 yiaA/B two helix domain FORC47_0284 ENOG4105CBD Diacylglycerol kinase FORC47_0286 ENOG4108JPW Aminotransferase FORC47_0288 ENOG4105C26 Dehydrogenase FORC47_0289 ENOG4105KPY Small multidrug resistance protein FORC47_0295 ENOG4105D9N nucleoside FORC47_0296 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FORC47_0298 ENOG4108W15 Protein of unknown function (DUF1456) FORC47_0301 ENOG4105DTQ mandelate racemase muconate lactonizing FORC47_0303 ENOG4105DFD Na H antiporter FORC47_0307 ENOG4105D3R alkyl hydroperoxide reductase FORC47_0308 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FORC47_0309 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FORC47_0310 ENOG4107W7X Aldolase FORC47_0312 ENOG4105EHG Permease protein FORC47_0313 ENOG4105DQ5 transport system permease protein FORC47_0314 ENOG4108V5C ABC transporter FORC47_0315 ENOG4105CAY ferredoxin--nadp reductase FORC47_0319 ENOG4106UIA FORC47_0320 ENOG4106UIA FORC47_0323 ENOG4105BZU Histidine kinase FORC47_0327 ENOG410756H nucleotidyltransferase FORC47_0328 ENOG4105D2S major facilitator superfamily FORC47_0331 ENOG4105E5Q amino acid AbC transporter FORC47_0332 ENOG4105EAB amino acid AbC transporter FORC47_0334 ENOG4105C8Q Methyl-accepting chemotaxis FORC47_0337 ENOG4105DBV ornithine carbamoyltransferase FORC47_0339 ENOG4105C5B carbamate kinase FORC47_0340 ENOG4108W63 CRP FNR family transcriptional regulator FORC47_0342 ENOG4105DNP FAD linked oxidase domain protein FORC47_0344 ENOG4105CI1 PTS System FORC47_0347 ENOG4105C9U ATP-dependent DNA helicase RecQ FORC47_0350 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FORC47_0354 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FORC47_0355 ENOG4105D2X ABC transporter substrate-binding protein FORC47_0357 ENOG4105C5H ABC transporter FORC47_0363 ENOG41062JF Transcriptional regulator FORC47_0366 ENOG4105DEU major facilitator superfamily FORC47_0369 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FORC47_0372 ENOG4108N0M stress protein FORC47_0373 ENOG4106FN3 tellurium resistance protein FORC47_0374 ENOG4106FN3 tellurium resistance protein FORC47_0375 ENOG4107TS3 membrane protein, TerC FORC47_0376 ENOG4108TTB tellurium resistance protein FORC47_0380 ENOG41068PA UPF0435 protein FORC47_0381 ENOG4105KJF protein tyrosine phosphatase FORC47_0383 ENOG4107U9T Pfam:Ribonuclease_BN FORC47_0384 ENOG4105C59 p-type ATPase FORC47_0385 ENOG4108IPJ Membrane FORC47_0387 ENOG4105C3F Signal peptidase i FORC47_0389 ENOG4107ZTW SNARE associated Golgi FORC47_0392 ENOG410606W general stress protein FORC47_0393 ENOG4105UPD Calcium Proton FORC47_0400 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FORC47_0401 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FORC47_0403 ENOG4108JUB Transcriptional regulator FORC47_0405 ENOG4108IQI permease FORC47_0412 ENOG4108A04 Beta-lactamase FORC47_0415 ENOG4107R51 Glycosyl transferase, family 2 FORC47_0416 ENOG4107QQG Dehydrogenase FORC47_0417 ENOG4105C3I Nad-dependent epimerase dehydratase FORC47_0418 ENOG4105CKK Glycosyl transferase, family 2 FORC47_0420 ENOG4105F1A Pyruvate formate-lyase FORC47_0423 ENOG4105CI2 imidazolone-5-propionate hydrolase FORC47_0424 ENOG4105ECP epimerase FORC47_0430 ENOG41067AE Membrane-bound metal-dependent hydrolase FORC47_0431 ENOG4105CEN a g-specific adenine glycosylase FORC47_0432 ENOG4106BXE FORC47_0436 ENOG4105BZ1 (ABC) transporter FORC47_0437 ENOG4107NBY Membrane FORC47_0439 ENOG4105CBC glutamate synthase FORC47_0441 ENOG4108IUW ABC transporter FORC47_0445 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC47_0446 ENOG4105G5W regulator Fur family FORC47_0452 ENOG4108JQC penicillin-binding protein 1A FORC47_0453 ENOG4108R9S DSBA oxidoreductase FORC47_0454 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FORC47_0456 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FORC47_0458 ENOG4105CYN Serine protein kinase FORC47_0462 ENOG4105C94 Transporter FORC47_0465 ENOG4105DZ6 Band 7 protein FORC47_0467 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FORC47_0468 ENOG4108V9W transcriptional regulatory protein FORC47_0469 ENOG4105D4T Citrate transporter FORC47_0475 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FORC47_0476 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC47_0477 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FORC47_0478 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FORC47_0479 ENOG4105BZ7 extracellular solute-binding protein family 1 FORC47_0480 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FORC47_0481 ENOG4108STX response regulator FORC47_0482 ENOG4105US7 Histidine kinase FORC47_0487 ENOG4108MRH transcriptional regulatory protein FORC47_0489 ENOG4105C6K Malic enzyme FORC47_0491 ENOG4108UZ3 Transporter FORC47_0492 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC47_0494 ENOG4105BZU Histidine kinase FORC47_0495 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC47_0497 ENOG4105IYK transposase FORC47_0498 ENOG4105DQ6 Transposase FORC47_0500 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FORC47_0501 ENOG4108JB9 formate dehydrogenase FORC47_0505 ENOG4105CUB amino acid FORC47_0507 ENOG4105C59 p-type ATPase FORC47_0508 ENOG4105DAP Nicotinate phosphoribosyltransferase FORC47_0515 ENOG41073R8 VanW family FORC47_0516 ENOG4108KGH TRANSCRIPTIONal FORC47_0517 ENOG4105D9N nucleoside FORC47_0518 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FORC47_0519 ENOG4105C37 (CBS) domain FORC47_0520 ENOG4108IJ0 Aspartate ammonia-lyase FORC47_0521 ENOG4105DAA L-lactate FORC47_0524 ENOG4105DUX Transporter FORC47_0525 ENOG4108MES Periplasmic binding protein FORC47_0526 ENOG4105DQ5 transport system permease protein FORC47_0527 ENOG4108IHU transport system permease protein FORC47_0528 ENOG4105E0A ABC, transporter FORC47_0530 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FORC47_0531 ENOG4105EXW epimerase dehydratase FORC47_0532 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FORC47_0534 ENOG4107T89 von Willebrand factor, type A FORC47_0535 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FORC47_0536 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FORC47_0538 ENOG4105BZU Histidine kinase FORC47_0539 ENOG4105D5Q Arginine ornithine antiporter FORC47_0540 ENOG4107414 GntR family transcriptional regulator FORC47_0541 ENOG4105C5Y PTS System FORC47_0542 ENOG4105CG3 alpha amylase, catalytic region FORC47_0545 ENOG4105E1K spore germination protein FORC47_0546 ENOG4108XG2 Histidine kinase FORC47_0547 ENOG4105WH1 Two component transcriptional regulator luxr family FORC47_0548 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FORC47_0550 ENOG4105CRN Aminoglycoside phosphotransferase FORC47_0551 ENOG4105BZG amino acid carrier protein FORC47_0552 ENOG4105CDA abc transporter atp-binding protein FORC47_0553 ENOG4105CT1 (ABC) transporter FORC47_0554 ENOG4105EAD ABC transporter FORC47_0555 ENOG4105DRP amino acid AbC transporter FORC47_0556 ENOG4108IQI permease FORC47_0559 ENOG4105GFR rna polymerase sigma factor FORC47_0561 ENOG4105D29 Helix-turn-helix type 11 domain protein FORC47_0562 ENOG4105NAE bifunctional deaminase-reductase domain protein FORC47_0563 ENOG4105BZU Histidine kinase FORC47_0566 ENOG4105CHH sulfate transporter FORC47_0567 ENOG41068KF Universal stress protein FORC47_0569 ENOG4105DEF Extracellular solute-binding protein, family 5 FORC47_0571 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FORC47_0572 ENOG4108JQ7 (ABC) transporter FORC47_0574 ENOG4105CXY transporter FORC47_0575 ENOG41067TZ transcriptional regulator, MarR family FORC47_0576 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC47_0577 ENOG4105ETE Transcriptional regulator (LacI family FORC47_0578 ENOG4108RVA ribokinase FORC47_0580 ENOG4105C2J ABC transporter FORC47_0581 ENOG4105CNN ABC, transporter FORC47_0582 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FORC47_0583 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FORC47_0591 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) FORC47_0597 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FORC47_0598 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FORC47_0599 ENOG41069ER domain protein FORC47_0600 ENOG4105VZ8 Transcriptional regulator FORC47_0601 ENOG4107D63 FORC47_0604 ENOG4105DUX Transporter FORC47_0608 ENOG4105C85 amino acid FORC47_0609 ENOG4105C7N Xanthine uracil vitamin C permease FORC47_0612 ENOG4105MA6 gCN5-related N-acetyltransferase FORC47_0616 ENOG4105CCU oxidase (Subunit III) FORC47_0617 ENOG4105BZ9 Cytochrome C oxidase, subunit I FORC47_0618 ENOG4105E2S oxidase) subunit II FORC47_0622 ENOG4106CAD Protein of unknown function (DUF3311) FORC47_0623 ENOG4105E1V na solute symporter FORC47_0626 ENOG4108NHD germination protein FORC47_0628 ENOG4105CE1 Ferrous iron transport protein b FORC47_0629 ENOG4105CE1 Ferrous iron transport protein b FORC47_0630 ENOG4105CVA phosphate FORC47_0631 ENOG4105C8U phosphate abc transporter FORC47_0632 ENOG4105E2Z phosphate ABC transporter (Permease FORC47_0635 ENOG41080XQ Signal transduction protein with cbs domains FORC47_0639 ENOG4105ETU transcriptional activator (TenA FORC47_0641 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FORC47_0643 ENOG4108VEU Thiamine monophosphate synthase FORC47_0644 ENOG41080HI glycine oxidase FORC47_0647 ENOG4105D06 uba thif-type nad fad binding protein FORC47_0648 ENOG4105DWF phosphomethylpyrimidine kinase FORC47_0654 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) FORC47_0657 ENOG4108INS Transcriptional regulator FORC47_0660 ENOG4105C7N Xanthine uracil vitamin C permease FORC47_0662 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FORC47_0665 ENOG4105K63 Thioredoxin FORC47_0669 ENOG4108B31 Spore germination protein FORC47_0673 ENOG4107Y03 Nitroreductase FORC47_0674 ENOG4105ED1 spovr family FORC47_0676 ENOG4108TCS Glutamyl endopeptidase FORC47_0677 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FORC47_0678 ENOG4105XTG Pfam:DUF156 FORC47_0679 ENOG4105VFE sira family FORC47_0680 ENOG4107TPS domain protein FORC47_0681 ENOG4105VFE sira family FORC47_0684 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FORC47_0685 ENOG41087NI Sulfite exporter TauE/SafE FORC47_0687 ENOG4108KGH TRANSCRIPTIONal FORC47_0692 ENOG4105EMD TRANSCRIPTIONal FORC47_0693 ENOG4105VCP PTS System FORC47_0694 ENOG4105VZJ PTS System FORC47_0697 ENOG41069ER domain protein FORC47_0698 ENOG4107RBB ABC transporter, permease FORC47_0699 ENOG4105C19 ABC transporter FORC47_0705 ENOG4105WEF catalase FORC47_0712 ENOG4107T5V SNARE associated Golgi FORC47_0719 ENOG4105CUB amino acid FORC47_0720 ENOG4107RWR Sodium hydrogen exchanger FORC47_0722 ENOG4106KNT transcriptional regulator FORC47_0730 ENOG4108YXU transcriptional regulator AsnC family FORC47_0731 ENOG4105CH7 arginosuccinase FORC47_0732 ENOG4105UBK short-chain dehydrogenase reductase FORC47_0733 ENOG4105VUF Transcriptional regulator FORC47_0734 ENOG4105KPY Small multidrug resistance protein FORC47_0741 ENOG4105DEF Extracellular solute-binding protein, family 5 FORC47_0742 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FORC47_0743 ENOG4105E5W Transporter FORC47_0746 ENOG4107RKG DJ-1/PfpI family FORC47_0748 ENOG4105D5Q Arginine ornithine antiporter FORC47_0749 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FORC47_0751 ENOG4105C26 Dehydrogenase FORC47_0752 ENOG4105BZ1 (ABC) transporter FORC47_0753 ENOG4105BZ1 (ABC) transporter FORC47_0755 ENOG4105DRP amino acid AbC transporter FORC47_0756 ENOG4105CDA abc transporter atp-binding protein FORC47_0759 ENOG410839P FORC47_0761 ENOG4108UH6 UPF0754 membrane protein FORC47_0766 ENOG4107FQX Alpha-acetolactate decarboxylase FORC47_0767 ENOG4108VX5 3-methyladenine DNA glycosylase FORC47_0770 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FORC47_0771 ENOG4105D4P Coproporphyrinogen iii oxidase FORC47_0775 ENOG4105CHH sulfate transporter FORC47_0780 ENOG4105CGU Enoyl-CoA hydratase FORC47_0784 ENOG4105DER m42 family FORC47_0789 ENOG4105CIF Ornithine Cyclodeaminase FORC47_0793 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC47_0794 ENOG4105C3U ABC transporter FORC47_0795 ENOG4108JQ7 (ABC) transporter FORC47_0804 ENOG4105CSH Transporter FORC47_0806 ENOG4108MRH transcriptional regulatory protein FORC47_0831 ENOG4105CDU Replicative dna helicase FORC47_0837 ENOG4108FPN Integrase FORC47_0838 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FORC47_0843 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC47_0847 ENOG4105D9U N-acetyltransferase FORC47_0854 ENOG4105F6J Alpha beta hydrolase fold FORC47_0861 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FORC47_0864 ENOG4105F27 Major Facilitator FORC47_0865 ENOG4105WAB arsR family transcriptional regulator FORC47_0867 ENOG4105CMT Dihydroxyacetone kinase FORC47_0869 ENOG4105CMT Dihydroxyacetone kinase FORC47_0894 ENOG4105WN5 stage II sporulation protein FORC47_0896 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC47_0898 ENOG4108MJI response regulator FORC47_0899 ENOG4105BZU Histidine kinase FORC47_0900 ENOG4105BZU Histidine kinase FORC47_0905 ENOG4105K8R UPF0145 protein FORC47_0910 ENOG4107QHE Choloylglycine hydrolase FORC47_0914 ENOG4107VRP DNA repair exonuclease FORC47_0915 ENOG4106D4I domain protein FORC47_0918 ENOG410829K Lysine exporter protein (Lyse ygga) FORC47_0922 ENOG4108MUZ hydrolase FORC47_0926 ENOG4105F0F Oxalate decarboxylase FORC47_0927 ENOG41067QW Transcriptional regulator FORC47_0928 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FORC47_0931 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FORC47_0935 ENOG4105EMN RNA polymerase sigma factor FORC47_0937 ENOG4105CNI cell division protein FtsW FORC47_0938 ENOG4105EEM helicase FORC47_0940 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC47_0945 ENOG4105K59 histidine triad (HIT) protein FORC47_0952 ENOG410905X membrane-flanked domain protein FORC47_0953 ENOG4105CKV Membrane FORC47_0964 ENOG410905X membrane-flanked domain protein FORC47_0965 ENOG4105CKV Membrane FORC47_0966 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FORC47_0967 ENOG4105BZ4 penicillin-binding protein FORC47_0969 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FORC47_0970 ENOG4105C1Q protoporphyrinogen oxidase FORC47_0975 ENOG4105NA0 Transcriptional regulator FORC47_0978 ENOG4105ECB domain protein FORC47_0982 ENOG4108MK9 spermidine N(1)-acetyltransferase FORC47_0984 ENOG4106AXD FORC47_0985 ENOG4108RQ5 Beta-lactamase domain-containing protein FORC47_0986 ENOG4105DF9 Lipoate-protein, ligase FORC47_0988 ENOG4105CEY Amp-dependent synthetase and ligase FORC47_0990 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FORC47_0991 ENOG4108I5D sulfate abc transporter FORC47_0992 ENOG4105ECW sulfate abc transporter FORC47_0993 ENOG4108IJ6 ABC transporter FORC47_0994 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) FORC47_0995 ENOG4107RN3 metallophosphoesterase FORC47_0996 ENOG4107TVP HD domain protein FORC47_0998 ENOG4108AEY RNA polymerase sigma factor FORC47_0999 ENOG41086D8 Transcriptional regulator FORC47_1002 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC47_1006 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FORC47_1007 ENOG4105C8Q Methyl-accepting chemotaxis FORC47_1008 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) FORC47_1010 ENOG4107QP3 malate synthase g FORC47_1014 ENOG4105VEQ Cold shock protein FORC47_1021 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FORC47_1030 ENOG4105ERH Fumarylacetoacetate hydrolase FORC47_1032 ENOG4105C8Y Acetylornithine aminotransferase FORC47_1033 ENOG4106BKT UPF0344 protein FORC47_1035 ENOG4105CAQ asparagine synthetase FORC47_1036 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FORC47_1037 ENOG4105CH6 catalase FORC47_1038 ENOG4105BZU Histidine kinase FORC47_1042 ENOG4105QNR S1 RNA binding domain protein FORC47_1043 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC47_1045 ENOG4107AYK membrAne FORC47_1046 ENOG41073B9 FORC47_1048 ENOG4108KP7 hydrolase FORC47_1050 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FORC47_1056 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FORC47_1057 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FORC47_1060 ENOG4105C31 Tryptophanyl-tRNA synthetase FORC47_1063 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FORC47_1064 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC47_1066 ENOG4108JQ7 (ABC) transporter FORC47_1067 ENOG4105DQ6 Transposase FORC47_1068 ENOG4105IYK transposase FORC47_1069 ENOG4105UQX Mate efflux family protein FORC47_1073 ENOG4108ZCF integral membrane protein FORC47_1075 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FORC47_1077 ENOG4105DPN Oligoendopeptidase f FORC47_1080 ENOG4108Z18 K06886 hemoglobin FORC47_1081 ENOG4105MIX Adenylate cyclase FORC47_1082 ENOG4106EFP UPF0738 protein FORC47_1084 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FORC47_1085 ENOG4105EMS pseudouridine synthase FORC47_1089 ENOG4105K64 Glycosyl transferase, family 2 FORC47_1093 ENOG4107TVC Glycosyl transferase, family 2 FORC47_1097 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FORC47_1098 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FORC47_1100 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FORC47_1117 ENOG4105CK7 Sodium proline symporter FORC47_1119 ENOG4105CRQ synthase (Component I) FORC47_1120 ENOG4105DDQ anthranilate synthase FORC47_1122 ENOG4105DK0 Indole-3-glycerol phosphate synthase FORC47_1137 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FORC47_1141 ENOG4105C7S Dehydrogenase FORC47_1142 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FORC47_1144 ENOG4105VZ8 Transcriptional regulator FORC47_1152 ENOG4108IUX (ABC) transporter FORC47_1153 ENOG4105RHA ABC transporter, permease FORC47_1162 ENOG4108C33 Resolvase FORC47_1166 ENOG4105DXX methyltransferase FORC47_1168 ENOG4105VTR Integrase FORC47_1171 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FORC47_1173 ENOG4105DZ1 carboxypeptidase FORC47_1174 ENOG4105VFR signal peptidase FORC47_1181 ENOG4105C26 Dehydrogenase FORC47_1182 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC47_1183 ENOG4105F38 ABC transporter, permease FORC47_1184 ENOG4105D38 putrescine abc transporter FORC47_1185 ENOG4107RUE extracellular solute-binding protein family 1 FORC47_1187 ENOG4105EYF MMPL domain protein FORC47_1189 ENOG4108YBP pseudouridine synthase FORC47_1191 ENOG4105K4I Scp-like extracellular FORC47_1192 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FORC47_1193 ENOG4105CQB FAD linked oxidase domain protein FORC47_1196 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC47_1197 ENOG4105BZU Histidine kinase FORC47_1198 ENOG4105JXH GntR family transcriptional regulator FORC47_1202 ENOG4106A3R peptidase FORC47_1204 ENOG4108QTI )-transporter FORC47_1205 ENOG4107TS3 membrane protein, TerC FORC47_1206 ENOG4105CZN Potassium uptake protein FORC47_1207 ENOG410681C small acid-soluble spore protein FORC47_1208 ENOG4108Z7G MaoC domain protein dehydratase FORC47_1212 ENOG4105CHR reductase FORC47_1218 ENOG4105C4Y ABC transporter FORC47_1219 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC47_1220 ENOG4107RCV ABC transporter, permease FORC47_1224 ENOG4105E98 transcriptional regulator DeoR family FORC47_1227 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FORC47_1229 ENOG4105PXI polysaccharide deacetylase FORC47_1231 ENOG4105BZU Histidine kinase FORC47_1232 ENOG41090MY MarR family Transcriptional regulator FORC47_1234 ENOG4106DF1 FORC47_1235 ENOG4105BZU Histidine kinase FORC47_1236 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FORC47_1237 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FORC47_1238 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FORC47_1246 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FORC47_1247 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FORC47_1248 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FORC47_1249 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FORC47_1250 ENOG4105CZV ABC transporter FORC47_1252 ENOG4105CJ1 ABC, transporter FORC47_1260 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FORC47_1261 ENOG4105EA8 2-Nitropropane dioxygenase FORC47_1262 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FORC47_1264 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FORC47_1269 ENOG4105NQC Flavodoxin FORC47_1277 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FORC47_1284 ENOG4105CZN Potassium uptake protein FORC47_1285 ENOG41063Y9 FORC47_1286 ENOG4105KBJ sporulation protein ytfj FORC47_1289 ENOG4105CM2 brancheD-chain amino acid aminotransferase FORC47_1290 ENOG4105C7K acetolactate synthase FORC47_1291 ENOG4108ZP8 Acetolactate synthase small subunit FORC47_1292 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FORC47_1295 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FORC47_1299 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FORC47_1300 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FORC47_1301 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FORC47_1306 ENOG4107RVV histidinol phosphate phosphatase, hisj family FORC47_1309 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FORC47_1310 ENOG4105E0M Sulfatase FORC47_1312 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FORC47_1316 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FORC47_1317 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FORC47_1319 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FORC47_1320 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FORC47_1321 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FORC47_1322 ENOG4105C8J )-transporter FORC47_1327 ENOG4105DFD Na H antiporter FORC47_1331 ENOG4105ENE Histidine kinase FORC47_1332 ENOG4105WH1 Two component transcriptional regulator luxr family FORC47_1336 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FORC47_1341 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FORC47_1345 ENOG4105CJ3 phosphate transporter FORC47_1346 ENOG4107GRR phosphate transport regulator FORC47_1347 ENOG4105BZ4 penicillin-binding protein FORC47_1350 ENOG4105BZU Histidine kinase FORC47_1351 ENOG4105I3N Conserved Protein FORC47_1354 ENOG4105BZU Histidine kinase FORC47_1360 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FORC47_1361 ENOG4105DZ1 carboxypeptidase FORC47_1362 ENOG4108JIC nucleoside recognition domain protein FORC47_1364 ENOG4105FE9 pseudouridine synthase FORC47_1365 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC47_1366 ENOG4107TWT Cytochrome c biogenesis protein FORC47_1367 ENOG4105CRE cytochrome C FORC47_1368 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC47_1369 ENOG4105BZU Histidine kinase FORC47_1370 ENOG4108WBT adenosyltransferase FORC47_1373 ENOG4108SAX Membrane FORC47_1376 ENOG4105C9U ATP-dependent DNA helicase RecQ FORC47_1377 ENOG4105I7S Abortive infection protein FORC47_1379 ENOG4107RGJ metallophosphoesterase FORC47_1380 ENOG4108XDN Transcriptional regulator FORC47_1381 ENOG4108S6Z Negative regulator of genetic competence FORC47_1386 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FORC47_1387 ENOG4107RB3 L-asparaginase FORC47_1394 ENOG4105S2F FORC47_1395 ENOG41065D1 FORC47_1401 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FORC47_1404 ENOG4105XXQ heptaprenyl diphosphate synthase component I FORC47_1406 ENOG4105EAH synthase FORC47_1407 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FORC47_1408 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FORC47_1411 ENOG41068YB TPR repeat-containing protein FORC47_1414 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FORC47_1415 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FORC47_1422 ENOG4108JYZ YitT family FORC47_1423 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FORC47_1426 ENOG4105FJR Lmbe family FORC47_1427 ENOG4105CPK Glycosyl transferase (Group 1 FORC47_1430 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FORC47_1433 ENOG4105DVT helicase FORC47_1434 ENOG4105YAC FORC47_1438 ENOG4105CSM endonuclease III FORC47_1440 ENOG4105BZ4 penicillin-binding protein FORC47_1448 ENOG4106F55 Protein of unknown function (DUF1273) FORC47_1450 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FORC47_1452 ENOG4105DVT helicase FORC47_1453 ENOG4105CTD carboxy-peptidase FORC47_1455 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FORC47_1457 ENOG4105C2W permease FORC47_1458 ENOG4105DHF Membrane FORC47_1460 ENOG410890F Dynamin family FORC47_1462 ENOG4108W0I acetyltransferase FORC47_1464 ENOG4105KHC sulfurtransferase FORC47_1473 ENOG4105HTX biosynthesis protein FORC47_1480 ENOG4105CPK Glycosyl transferase (Group 1 FORC47_1487 ENOG41081VK Ribonuclease FORC47_1500 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FORC47_1502 ENOG4107RWR Sodium hydrogen exchanger FORC47_1503 ENOG4108Z5V transcriptional regulator, merr family FORC47_1505 ENOG4105H67 Protein of unknown function (DUF421) FORC47_1506 ENOG41080C8 DUF218 domain FORC47_1519 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FORC47_1521 ENOG4107R0U MotA TolQ exbB proton channel FORC47_1522 ENOG4105ER2 Ompa motb domain protein FORC47_1523 ENOG4107YTP response regulator receiver protein FORC47_1524 ENOG4105CBS Chea signal transduction histidine kinase FORC47_1525 ENOG4105DD5 Flagellar motor switch protein FORC47_1528 ENOG4105BZU Histidine kinase FORC47_1532 ENOG4105E1Q flagellar hook-associated protein FORC47_1533 ENOG4105DTJ flagellar hook-associated protein FORC47_1537 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FORC47_1538 ENOG4108ZC9 flagellar basal-body rod protein flgc FORC47_1539 ENOG41075Z6 flagellar hook-basal body complex protein fliE FORC47_1540 ENOG4107U2N Flagellar M-ring protein FORC47_1541 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FORC47_1547 ENOG4105BZE flagellar hook protein, FlgE FORC47_1550 ENOG4107R88 Chemotaxis protein (CheV) FORC47_1552 ENOG4105I03 Flagellin FORC47_1553 ENOG4105I03 Flagellin FORC47_1554 ENOG4105E4C Lytic transglycosylase catalytic FORC47_1556 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FORC47_1557 ENOG4105DD5 Flagellar motor switch protein FORC47_1559 ENOG4105CN7 Flagellar biosynthetic protein FliP FORC47_1560 ENOG4105VS8 Flagellar biosynthetic protein fliq FORC47_1562 ENOG4105D00 flagellar biosynthetic protein flhB FORC47_1563 ENOG4105D7B Flagellar biosynthesis protein flha FORC47_1564 ENOG4105FZW flagellar biosynthesis regulator FlhF FORC47_1565 ENOG4105KTQ flagellar basal-body rod protein FORC47_1573 ENOG4105KAC Antibiotic biosynthesis monooxygenase FORC47_1574 ENOG4107QZ7 Cellulose synthase catalytic subunit FORC47_1579 ENOG4105DUM transcriptional regulator, lysR family FORC47_1580 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC47_1582 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FORC47_1589 ENOG4105CVJ phosphoglycerate mutase FORC47_1591 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FORC47_1595 ENOG4105CAQ asparagine synthetase FORC47_1599 ENOG4105PGM cation diffusion facilitator family transporter FORC47_1601 ENOG4105DRR Transcriptional regulator, GntR family FORC47_1602 ENOG4108UZ3 Transporter FORC47_1604 ENOG4105CKI cobalamin synthesis protein FORC47_1605 ENOG4108PJD permease FORC47_1608 ENOG4105DFD Na H antiporter FORC47_1609 ENOG4105VUF Transcriptional regulator FORC47_1611 ENOG4105C9Q fumarate hydratase class II FORC47_1615 ENOG4107QJQ Mate efflux family protein FORC47_1616 ENOG4105EC3 peptidase S51, dipeptidase E FORC47_1620 ENOG4107QIV Cytochrome c biogenesis protein FORC47_1621 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC47_1624 ENOG4105BZC d-serine deaminase FORC47_1625 ENOG4106BRA Membrane FORC47_1632 ENOG4105CJ1 ABC, transporter FORC47_1637 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FORC47_1640 ENOG4108IJ0 Aspartate ammonia-lyase FORC47_1641 ENOG4105C6K Malic enzyme FORC47_1653 ENOG4105FVX FORC47_1654 ENOG4105E09 nadh pyrophosphatase FORC47_1657 ENOG4105CSR polyphosphate kinase 2 FORC47_1658 ENOG4105U3E Transcriptional regulator FORC47_1661 ENOG4105DXI Major Facilitator superfamily FORC47_1664 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FORC47_1665 ENOG4105EU0 Major facilitator Superfamily FORC47_1666 ENOG4105C6T cysteine synthase FORC47_1669 ENOG4105C8J )-transporter FORC47_1671 ENOG4105X5K response regulator receiver protein FORC47_1672 ENOG4105H67 Protein of unknown function (DUF421) FORC47_1676 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FORC47_1677 ENOG4105CHR reductase FORC47_1678 ENOG4105CM2 brancheD-chain amino acid aminotransferase FORC47_1679 ENOG4105C7K acetolactate synthase FORC47_1681 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FORC47_1682 ENOG4105C01 Dihydroxy-acid dehydratase FORC47_1683 ENOG4105C7B Threonine dehydratase FORC47_1688 ENOG4105C6X Major Facilitator FORC47_1689 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FORC47_1691 ENOG4105DY9 regulatoR FORC47_1692 ENOG4105CYC Transferase FORC47_1693 ENOG4105K5X acetyltransferase FORC47_1695 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FORC47_1697 ENOG41068WN FORC47_1701 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FORC47_1704 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FORC47_1706 ENOG4105C0X amino acid FORC47_1714 ENOG410849A acetyltransferase, (GNAT) family FORC47_1715 ENOG4105K8R UPF0145 protein FORC47_1716 ENOG4108TYN CAAX amino terminal protease family protein FORC47_1718 ENOG4107RHR regulatoR FORC47_1721 ENOG4105D9N nucleoside FORC47_1722 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FORC47_1724 ENOG4105DQ6 Transposase FORC47_1725 ENOG4105IYK transposase FORC47_1730 ENOG410811B TRANSCRIPTIONal FORC47_1733 ENOG4107RAQ aminopeptidase FORC47_1735 ENOG4107R16 Multicopper oxidase FORC47_1743 ENOG4108T5E Copper resistance protein FORC47_1744 ENOG4105KTB nuclear export factor GLE1 FORC47_1745 ENOG4107RT3 EamA-like transporter family FORC47_1746 ENOG4105GZI Transcriptional regulator FORC47_1747 ENOG4108Z40 Transcriptional regulator FORC47_1748 ENOG4107ZXU DSBA oxidoreductase FORC47_1749 ENOG4108TVJ Nitroreductase FORC47_1754 ENOG4105D7V transposase FORC47_1755 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FORC47_1756 ENOG4106F5Q Membrane FORC47_1757 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FORC47_1759 ENOG4105CKI cobalamin synthesis protein FORC47_1761 ENOG4105C0Z ABC transporter FORC47_1762 ENOG4108IV0 ABC, transporter FORC47_1765 ENOG4105EGI Transcriptional regulator FORC47_1767 ENOG4105MDS 4-oxalocrotonate tautomerase FORC47_1772 ENOG4105C4M (Ubiquinol oxidase) subunit I FORC47_1773 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FORC47_1774 ENOG4108JJ9 ABC, transporter FORC47_1775 ENOG4108JJ8 (ABC) transporter FORC47_1777 ENOG4105K64 Glycosyl transferase, family 2 FORC47_1779 ENOG4108UT6 Transferase hexapeptide repeat containing protein FORC47_1791 ENOG4105BZ1 (ABC) transporter FORC47_1792 ENOG4105EFI regulatoR FORC47_1793 ENOG4105BZU Histidine kinase FORC47_1796 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FORC47_1797 ENOG4108ZJ4 polysaccharide deacetylase FORC47_1801 ENOG4105D6E homoserine dehydrogenase FORC47_1803 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FORC47_1806 ENOG4108KGH TRANSCRIPTIONal FORC47_1807 ENOG4107VMI polysaccharide deacetylase FORC47_1809 ENOG4105KT7 mgtC SapB transporter FORC47_1811 ENOG4105DQ6 Transposase FORC47_1812 ENOG4105VRR gCN5-related N-acetyltransferase FORC47_1814 ENOG4105DUU IucA IucC family protein FORC47_1815 ENOG4105CEY Amp-dependent synthetase and ligase FORC47_1818 ENOG4108WBH protein TIM barrel FORC47_1819 ENOG4105YWU small acid-soluble spore protein FORC47_1821 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FORC47_1822 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC47_1832 ENOG4105KRN Transcriptional regulator, abrb family FORC47_1834 ENOG4105YVS arsR family transcriptional regulator FORC47_1835 ENOG4105CPC Aldo Keto reductase FORC47_1836 ENOG4107XZQ multidrug resistance protein FORC47_1841 ENOG4105C8Q Methyl-accepting chemotaxis FORC47_1844 ENOG4108K88 Membrane FORC47_1845 ENOG4108WPJ Ferritin-like domain FORC47_1848 ENOG4105DEN Luciferase family FORC47_1851 ENOG4105VMI -acetyltransferase FORC47_1852 ENOG4107QM2 Aldo Keto reductase FORC47_1854 ENOG4105CKI cobalamin synthesis protein FORC47_1856 ENOG4105DSE periplasmic solute binding protein FORC47_1858 ENOG4105K4T epimerase FORC47_1860 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FORC47_1869 ENOG4107T5V SNARE associated Golgi FORC47_1872 ENOG4108PJD permease FORC47_1874 ENOG4108S4H thioesterase Superfamily protein FORC47_1876 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FORC47_1880 ENOG4105SXS Protein of unknown function (DUF456) FORC47_1881 ENOG4105C37 (CBS) domain FORC47_1886 ENOG4105DQ6 Transposase FORC47_1887 ENOG4105IYK transposase FORC47_1889 ENOG4108Z7R Chaperone CsaA FORC47_1892 ENOG4108ZRV stage ii sporulation protein p FORC47_1894 ENOG4108VXD carboxy-peptidase FORC47_1900 ENOG4108ZRV stage ii sporulation protein p FORC47_1902 ENOG4108X4Q Hydrolase FORC47_1903 ENOG41082F9 transcriptional regulator FORC47_1904 ENOG4105D94 Major Facilitator Superfamily FORC47_1906 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FORC47_1910 ENOG41087PP glycosyltransferase MGT family FORC47_1911 ENOG4108JYZ YitT family FORC47_1912 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC47_1918 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FORC47_1922 ENOG4106PAW secretion accessory protein EsaA YueB FORC47_1924 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) FORC47_1925 ENOG4108MGT Required for secretion of EsxA and EsxB FORC47_1940 ENOG4105KBJ sporulation protein ytfj FORC47_1945 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FORC47_1949 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) FORC47_1950 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FORC47_1952 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FORC47_1953 ENOG4105EMN RNA polymerase sigma factor FORC47_1956 ENOG4105CNW domain protein FORC47_1958 ENOG4108V06 Glutathione peroxidase FORC47_1961 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FORC47_1969 ENOG4105MCT stage V sporulation protein S FORC47_1972 ENOG4105C5H ABC transporter FORC47_1975 ENOG4108UUM single-stranded DNA-binding protein FORC47_1981 ENOG4107YX5 Pfam:DUF548 FORC47_1982 ENOG4105C75 arginyL-tRNA synthetase FORC47_1985 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FORC47_1990 ENOG4105C5S asparaginyl-tRNA synthetase FORC47_1991 ENOG4105C8J )-transporter FORC47_1995 ENOG4107XGZ Hydrolase FORC47_1996 ENOG4105CY2 Citrate transporter FORC47_2000 ENOG4105KD7 acetyltransferase FORC47_2002 ENOG4105VMP Transcriptional regulator FORC47_2003 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FORC47_2008 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FORC47_2012 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FORC47_2015 ENOG4107RVG penicillin-binding protein FORC47_2017 ENOG4105E9Q Acyl-transferase FORC47_2018 ENOG4108UT2 hemolysin iii FORC47_2020 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FORC47_2022 ENOG4108RCR degv family FORC47_2025 ENOG4108KF3 Electron transport protein SCO1 SenC FORC47_2026 ENOG4107Y70 Heat shock protein FORC47_2027 ENOG4105CAQ asparagine synthetase FORC47_2030 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FORC47_2031 ENOG4108MES Periplasmic binding protein FORC47_2032 ENOG4105F0I Aminotransferase FORC47_2037 ENOG4105E09 nadh pyrophosphatase FORC47_2038 ENOG4105D8X mechanosensitive ion channel FORC47_2039 ENOG4105BZU Histidine kinase FORC47_2040 ENOG4105WH1 Two component transcriptional regulator luxr family FORC47_2041 ENOG4106KNT transcriptional regulator FORC47_2042 ENOG4107ZY0 Phenazine biosynthesis-like protein FORC47_2046 ENOG4105CMG Carbohydrate kinase FORC47_2047 ENOG4105C6Z Gluconate FORC47_2049 ENOG4108YV3 Protein of unknown function (DUF2711) FORC47_2055 ENOG4108IJ8 ABC transporter FORC47_2056 ENOG4105E90 ABC transporter FORC47_2063 ENOG4105C37 (CBS) domain FORC47_2068 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FORC47_2071 ENOG4107S4Y M20 DapE family protein YgeY FORC47_2072 ENOG4108TSC N-acetyltransferase FORC47_2073 ENOG4108JUB Transcriptional regulator FORC47_2074 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FORC47_2083 ENOG410841Q phosphoesterase PA-phosphatase related protein FORC47_2086 ENOG4105SZ6 Thioredoxin FORC47_2087 ENOG4105KNA -acetyltransferase FORC47_2094 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC47_2106 ENOG4105BZ4 penicillin-binding protein FORC47_2108 ENOG4105CZM Major Facilitator FORC47_2109 ENOG4105W8X HesB YadR YfhF-family protein FORC47_2111 ENOG4105DXD 2-methylcitrate dehydratase FORC47_2112 ENOG4105CR4 methylisocitrate lyase FORC47_2113 ENOG4105C1G acyl-Coa dehydrogenase FORC47_2114 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FORC47_2116 ENOG4105N14 lysine exporter protein LysE YggA FORC47_2117 ENOG4105E39 Enoyl-CoA hydratase FORC47_2120 ENOG4107RFY SbcCD D subunit FORC47_2121 ENOG4105EYH Exonuclease FORC47_2126 ENOG4105FCD Major Facilitator FORC47_2127 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FORC47_2128 ENOG4105E4F Isochorismate synthase FORC47_2129 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FORC47_2130 ENOG4105WQI isochorismatase FORC47_2131 ENOG4105CEY Amp-dependent synthetase and ligase FORC47_2132 ENOG4105WQT MbtH domain protein FORC47_2133 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC47_2136 ENOG4105K70 DNA-binding protein FORC47_2140 ENOG4105BZG amino acid carrier protein FORC47_2144 ENOG4105FE9 pseudouridine synthase FORC47_2145 ENOG4105C22 threonyL-tRNA synthetase FORC47_2146 ENOG4105C19 ABC transporter FORC47_2148 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FORC47_2155 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FORC47_2159 ENOG41081I9 integral membrane protein FORC47_2161 ENOG4108Y4K DNA-binding transcriptional activator FORC47_2165 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FORC47_2167 ENOG4105EYF MMPL domain protein FORC47_2172 ENOG4105WCN acetyltransferase FORC47_2178 ENOG4105C1Q protoporphyrinogen oxidase FORC47_2180 ENOG41068WN FORC47_2186 ENOG4107V2S Transcriptional regulator FORC47_2187 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FORC47_2191 ENOG4105DND Transcriptional regulator FORC47_2192 ENOG4108RPX mosc domain containing protein FORC47_2195 ENOG4105BZ1 (ABC) transporter FORC47_2196 ENOG4105BZ1 (ABC) transporter FORC47_2202 ENOG4108JCI Transcriptional regulator FORC47_2209 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) FORC47_2210 ENOG4108KPJ rna polymerase sigma factor FORC47_2215 ENOG4105F32 YngK protein FORC47_2219 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) FORC47_2220 ENOG4105RD7 BadF BadG BcrA BcrD FORC47_2221 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FORC47_2223 ENOG4105C7B Threonine dehydratase FORC47_2224 ENOG4108INS Transcriptional regulator FORC47_2227 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FORC47_2230 ENOG4105C1J atp-dependent rna helicase FORC47_2249 ENOG41088CC tellurite resistance protein tehB FORC47_2251 ENOG4108I0C methyltransferase FORC47_2252 ENOG4107RA9 decarboxylase FORC47_2253 ENOG4105K56 Transcriptional regulator FORC47_2254 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FORC47_2259 ENOG4105CIN aminoacyl-histidine dipeptidase FORC47_2266 ENOG4105KRN Transcriptional regulator, abrb family FORC47_2268 ENOG4105EJ9 Membrane FORC47_2269 ENOG4105EQK -acetyltransferase FORC47_2277 ENOG4105W8Z 4'-phosphopantetheinyl transferase FORC47_2282 ENOG4105CSV Glutaminase FORC47_2287 ENOG4108Q8B Spore germination protein FORC47_2288 ENOG4108NHD germination protein FORC47_2289 ENOG4105II7 pyrroline-5-carboxylate reductase FORC47_2290 ENOG4105CUB amino acid FORC47_2292 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FORC47_2294 ENOG41075H3 AraC family transcriptional regulator FORC47_2299 ENOG4105BZU Histidine kinase FORC47_2301 ENOG4107S9D Alpha beta hydrolase FORC47_2315 ENOG4105EJQ L-serine dehydratase FORC47_2316 ENOG4105C44 Serine transporter FORC47_2320 ENOG4105F6S Spore photoproduct lyase FORC47_2322 ENOG4105CVK Glutamate decarboxylase FORC47_2323 ENOG4107QHE Choloylglycine hydrolase FORC47_2325 ENOG4108NHD germination protein FORC47_2327 ENOG4105CNI cell division protein FtsW FORC47_2328 ENOG4105CJW magnesium transporter FORC47_2330 ENOG4107RVG penicillin-binding protein FORC47_2334 ENOG4107RF6 penicillin-binding protein FORC47_2335 ENOG4107RF6 penicillin-binding protein FORC47_2338 ENOG4105DIN metallophosphoesterase FORC47_2340 ENOG4105CJ1 ABC, transporter FORC47_2342 ENOG4107Z3H Transcriptional regulator, TetR family FORC47_2345 ENOG4105C1G acyl-Coa dehydrogenase FORC47_2346 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FORC47_2347 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FORC47_2348 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FORC47_2349 ENOG4105E39 Enoyl-CoA hydratase FORC47_2350 ENOG4107QX3 carboxylase FORC47_2351 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FORC47_2353 ENOG4105DQ6 Transposase FORC47_2362 ENOG4105DZ1 carboxypeptidase FORC47_2366 ENOG4105T9C HD domain FORC47_2369 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FORC47_2374 ENOG41075H3 AraC family transcriptional regulator FORC47_2380 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FORC47_2382 ENOG4107Y80 Major Facilitator superfamily FORC47_2383 ENOG4105CHR reductase FORC47_2384 ENOG4105KVH Transcriptional regulator FORC47_2395 ENOG4105EFA 4-hydroxyphenylacetate FORC47_2398 ENOG4105CPQ Dehydrogenase FORC47_2400 ENOG410900G Protein of unknown function (DUF421) FORC47_2401 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FORC47_2402 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FORC47_2403 ENOG4108V4B ThiJ pfpI FORC47_2405 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FORC47_2408 ENOG4105DK7 lysyl-tRNA synthetase FORC47_2424 ENOG4105D6E homoserine dehydrogenase FORC47_2426 ENOG4105CPF Cell wall formation (By similarity) FORC47_2427 ENOG4105ETU transcriptional activator (TenA FORC47_2432 ENOG4105VTR Integrase FORC47_2442 ENOG4105KRN Transcriptional regulator, abrb family FORC47_2487 ENOG4105XSJ toxin secretion phage lysis holin FORC47_2508 ENOG410667J hydrolase FORC47_2509 ENOG4105BZU Histidine kinase FORC47_2510 ENOG4107RF6 penicillin-binding protein FORC47_2514 ENOG4108JJB ABC transporter FORC47_2517 ENOG4108HGU Histidine kinase FORC47_2532 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC47_2533 ENOG4105GR3 Histidine kinase FORC47_2534 ENOG4105CB2 alcohol dehydrogenase FORC47_2535 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FORC47_2536 ENOG4105CJN penicillin-binding protein FORC47_2537 ENOG4108IG5 Transcriptional regulator FORC47_2538 ENOG4105CHR reductase FORC47_2547 ENOG4107Y80 Major Facilitator superfamily FORC47_2550 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FORC47_2556 ENOG4107Y9U Membrane FORC47_2560 ENOG4105EGD dinuclear metal center protein, YbgI family FORC47_2565 ENOG4105FCD Major Facilitator FORC47_2567 ENOG4105E09 nadh pyrophosphatase FORC47_2568 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FORC47_2574 ENOG4108XI2 Domain of unknown function (DUF1963) FORC47_2579 ENOG4105D78 K07001 NTE family protein FORC47_2580 ENOG4105KWG Pfam:DUF1696 FORC47_2582 ENOG4108YYS metal-dependent hydrolase (By similarity) FORC47_2587 ENOG4105PKS Excinuclease abc c subunit domain protein FORC47_2595 ENOG4107VFR oxidoreductase FORC47_2601 ENOG4105U0R haloacid dehalogenase-like hydrolase FORC47_2602 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC47_2603 ENOG4105BZU Histidine kinase FORC47_2607 ENOG4107WD8 ABC transporter, permease FORC47_2610 ENOG4108IUM Glycogen debranching enzyme FORC47_2612 ENOG4105CGH 5'-nucleotidase FORC47_2616 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FORC47_2618 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) FORC47_2619 ENOG4105FDR Membrane FORC47_2621 ENOG4105CIS alcohol dehydrogenase FORC47_2622 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FORC47_2631 ENOG4105MSI germination protein ypeb FORC47_2637 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) FORC47_2638 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FORC47_2639 ENOG4107Z3H Transcriptional regulator, TetR family FORC47_2644 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FORC47_2648 ENOG4108PQ7 sgc region transcriptional regulator FORC47_2651 ENOG41062ES Transcriptional regulator FORC47_2655 ENOG4107QKR Dehydrogenase FORC47_2657 ENOG4107RUY (E1 component), alpha subunit FORC47_2660 ENOG4105E1F short-chain dehydrogenase reductase FORC47_2661 ENOG4105RHY Pfam:UPF0157 FORC47_2670 ENOG4107SQ8 Glycine betaine FORC47_2671 ENOG4108IJ7 Glycine betaine FORC47_2676 ENOG4105E66 phosphoriboisomerase A FORC47_2677 ENOG41082BV acetyltransferase FORC47_2678 ENOG4108M1A Chitin-binding protein FORC47_2685 ENOG4105MSB protein, conserved in bacteria FORC47_2690 ENOG4108Z7F N-acetyltransferase FORC47_2695 ENOG4105EEM helicase FORC47_2699 ENOG4105C9U ATP-dependent DNA helicase RecQ FORC47_2711 ENOG4108M1A Chitin-binding protein FORC47_2714 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FORC47_2716 ENOG4105BZG amino acid carrier protein FORC47_2717 ENOG4105C26 Dehydrogenase FORC47_2718 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FORC47_2719 ENOG4105CTU Proline racemase FORC47_2720 ENOG4105CTU Proline racemase FORC47_2721 ENOG41080HI glycine oxidase FORC47_2723 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FORC47_2729 ENOG4107T5V SNARE associated Golgi FORC47_2731 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FORC47_2732 ENOG4108428 Inherit from COG: -acetyltransferase FORC47_2735 ENOG4105DTQ mandelate racemase muconate lactonizing FORC47_2738 ENOG4107SET aldo keto reductase FORC47_2744 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FORC47_2745 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC47_2746 ENOG4105BZU Histidine kinase FORC47_2747 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC47_2751 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 FORC47_2754 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family FORC47_2756 ENOG4105DPN Oligoendopeptidase f FORC47_2757 ENOG4105EPR degv family FORC47_2769 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FORC47_2770 ENOG4106K7D Major facilitator family transporter FORC47_2775 ENOG4107BMA Transglycosylase associated protein FORC47_2778 ENOG41089UC methyltransferase, type 11 FORC47_2785 ENOG4105CHM Aminotransferase FORC47_2788 ENOG4108ZMI UPF0477 protein FORC47_2791 ENOG4105DVE abc transporter atp-binding protein FORC47_2802 ENOG4105C02 permease FORC47_2804 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FORC47_2805 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FORC47_2806 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FORC47_2807 ENOG4105D7T ABC transporter FORC47_2814 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FORC47_2822 ENOG4107VC0 DNA alkylation repair enzyme FORC47_2823 ENOG4105C6T cysteine synthase FORC47_2824 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FORC47_2827 ENOG4107VMI polysaccharide deacetylase FORC47_2829 ENOG4108ZCF integral membrane protein FORC47_2830 ENOG4105E0M Sulfatase FORC47_2831 ENOG4105C5H ABC transporter FORC47_2832 ENOG4105EYF MMPL domain protein FORC47_2833 ENOG41082JN Transcriptional regulator FORC47_2834 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FORC47_2839 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FORC47_2840 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FORC47_2849 ENOG41069ER domain protein FORC47_2851 ENOG4105DNP FAD linked oxidase domain protein FORC47_2856 ENOG4105D4B ABC, transporter FORC47_2857 ENOG4105F5R ABC transporter FORC47_2858 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FORC47_2860 ENOG4105DKT Transcriptional regulator FORC47_2861 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) FORC47_2863 ENOG41061GT Aldolase FORC47_2865 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FORC47_2871 ENOG4105II7 pyrroline-5-carboxylate reductase FORC47_2873 ENOG4107258 Transcriptional regulator FORC47_2879 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FORC47_2881 ENOG4105ECK Fatty Acid Desaturase FORC47_2883 ENOG4107RBI VanW family FORC47_2884 ENOG4105G6Z alkaline phosphatase FORC47_2886 ENOG4105VMP Transcriptional regulator FORC47_2890 ENOG41090T1 Membrane FORC47_2892 ENOG4108WCX response regulator FORC47_2894 ENOG41068WN FORC47_2901 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FORC47_2905 ENOG4105C8Y Acetylornithine aminotransferase FORC47_2914 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FORC47_2918 ENOG4108IBT Inherit from COG: transposase FORC47_2922 ENOG4108TVJ Nitroreductase FORC47_2923 ENOG4105FS7 Transcriptional regulator FORC47_2926 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FORC47_2930 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FORC47_2932 ENOG4105CMR udp-glucose 4-epimerase FORC47_2935 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF FORC47_2936 ENOG4108XET gCN5-related N-acetyltransferase FORC47_2941 ENOG4107XJU UPF0178 protein FORC47_2948 ENOG410635A Membrane FORC47_2950 ENOG4108IQI permease FORC47_2952 ENOG4105F1N DNA alkylation repair FORC47_2954 ENOG4105BZU Histidine kinase FORC47_2955 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC47_2957 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FORC47_2965 ENOG4107RF6 penicillin-binding protein FORC47_2966 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FORC47_2967 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) FORC47_2970 ENOG4105E7W lamb ycsf family protein FORC47_2972 ENOG4105P4J Allophanate hydrolase, subunit 1 FORC47_2973 ENOG4107258 Transcriptional regulator FORC47_2975 ENOG4106N3A copper homeostasis protein cutc FORC47_2976 ENOG4108ZHR arsR family transcriptional regulator FORC47_2978 ENOG4105FDT acyl-CoA dehydrogenase FORC47_2981 ENOG4105DWD nucleoside recognition domain protein FORC47_2990 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FORC47_2996 ENOG4105E2A Dehydrogenase FORC47_2998 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FORC47_3001 ENOG4105CGH 5'-nucleotidase FORC47_3003 ENOG4105CHJ isochorismatase hydrolase FORC47_3007 ENOG4107RSM transcriptional regulator FORC47_3008 ENOG41090MY MarR family Transcriptional regulator FORC47_3020 ENOG4105E1K spore germination protein FORC47_3024 ENOG4108606 TspO/MBR family FORC47_3025 ENOG4105CVP deoxyribo-dipyrimidine photolyase FORC47_3030 ENOG4108TWJ NADH dehydrogenase subunit 5 FORC47_3031 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FORC47_3032 ENOG4107VMI polysaccharide deacetylase FORC47_3033 ENOG4105KY5 gCN5-related N-acetyltransferase FORC47_3034 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FORC47_3036 ENOG4105D6J arsenicaL-resistance protein FORC47_3037 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FORC47_3038 ENOG41085FC arsR family transcriptional regulator FORC47_3040 ENOG4105NAE bifunctional deaminase-reductase domain protein FORC47_3045 ENOG41082BM Transcriptional regulator, arsr family FORC47_3048 ENOG4108IG5 Transcriptional regulator FORC47_3049 ENOG4105F27 Major Facilitator FORC47_3050 ENOG4105M4P Tetr family transcriptional regulator FORC47_3051 ENOG4105CHR reductase FORC47_3052 ENOG4108YXU transcriptional regulator AsnC family FORC47_3062 ENOG4105N0V mono-oxygenase ydhR FORC47_3069 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC47_3070 ENOG41062D9 Histidine kinase FORC47_3078 ENOG4105C19 ABC transporter FORC47_3084 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FORC47_3085 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC47_3090 ENOG4105K6H D-cysteine desulfhydrase FORC47_3092 ENOG4105E0Y RtcB Protein FORC47_3094 ENOG4105JQZ Methyltransferase FORC47_3097 ENOG4105IYK transposase FORC47_3098 ENOG4105DQ6 Transposase FORC47_3100 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FORC47_3104 ENOG4105BZU Histidine kinase FORC47_3106 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FORC47_3117 ENOG4108JPW Aminotransferase FORC47_3120 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FORC47_3122 ENOG4105DVH amino acid FORC47_3126 ENOG4108JQ1 Dehydrogenase FORC47_3127 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FORC47_3134 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FORC47_3156 ENOG4108VXD carboxy-peptidase FORC47_3157 ENOG4105PNM synthesis protein FORC47_3159 ENOG4108ISG Major Facilitator FORC47_3162 ENOG4107MII Sugar-specific transcriptional regulator TrmB FORC47_3163 ENOG4105CZM Major Facilitator FORC47_3165 ENOG4105CRW Short chain fatty acid transporter FORC47_3167 ENOG4105DYS nad(p)h dehydrogenase (quinone) FORC47_3174 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FORC47_3179 ENOG4108K8S endonuclease I FORC47_3181 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FORC47_3183 ENOG41067QW Transcriptional regulator FORC47_3186 ENOG4108Z66 YbaK ebsC protein FORC47_3188 ENOG4105KVH Transcriptional regulator FORC47_3189 ENOG4108RCM Nitroreductase FORC47_3195 ENOG4108PSK reductase FORC47_3211 ENOG4105C31 Tryptophanyl-tRNA synthetase FORC47_3212 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FORC47_3224 ENOG4105C37 (CBS) domain FORC47_3227 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FORC47_3228 ENOG4105FAW cDP-glucose 4,6-dehydratase FORC47_3235 ENOG4105DDN Pentapeptide repeat-containing protein FORC47_3236 ENOG4105XDF Protein of unknown function (DUF1272) FORC47_3237 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FORC47_3238 ENOG4105CMG Carbohydrate kinase FORC47_3239 ENOG4105C6Z Gluconate FORC47_3242 ENOG4105CV1 Transketolase (EC 2.2.1.1) FORC47_3243 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FORC47_3244 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FORC47_3245 ENOG4105CIS alcohol dehydrogenase FORC47_3246 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FORC47_3248 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FORC47_3251 ENOG4105C8Q Methyl-accepting chemotaxis FORC47_3253 ENOG4108UX3 '-nucleotidase FORC47_3254 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FORC47_3255 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FORC47_3256 ENOG4105KVH Transcriptional regulator FORC47_3260 ENOG41090KN UPF0303 protein FORC47_3262 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FORC47_3263 ENOG4105CHH sulfate transporter FORC47_3266 ENOG4105C44 Serine transporter FORC47_3271 ENOG4105KVH Transcriptional regulator FORC47_3272 ENOG4108TZY GntR Family Transcriptional Regulator FORC47_3273 ENOG4105D9R oxidoreductase FORC47_3274 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FORC47_3275 ENOG4105KVH Transcriptional regulator FORC47_3276 ENOG4105KVH Transcriptional regulator FORC47_3286 ENOG4105JAB phenazine biosynthesis protein, phzf family FORC47_3288 ENOG4105CHR reductase FORC47_3291 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FORC47_3292 ENOG4105KVH Transcriptional regulator FORC47_3295 ENOG4108ZJ4 polysaccharide deacetylase FORC47_3310 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FORC47_3312 ENOG4107YXZ hydrolase, family 25 FORC47_3319 ENOG4105H3G oxidoreductase FORC47_3334 ENOG4108TN2 lmbE family FORC47_3336 ENOG4107R3E Citrate transporter FORC47_3338 ENOG4105WCN acetyltransferase FORC47_3339 ENOG4108MES Periplasmic binding protein FORC47_3340 ENOG4105EHG Permease protein FORC47_3341 ENOG4105DQ5 transport system permease protein FORC47_3342 ENOG4105NX3 Membrane FORC47_3346 ENOG4107CUJ Protein of unknown function (DUF2690) FORC47_3349 ENOG4107V2S Transcriptional regulator FORC47_3351 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FORC47_3354 ENOG4105C98 muts2 protein FORC47_3355 ENOG4105E5K Alpha-amylase FORC47_3356 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FORC47_3357 ENOG4105DPN Oligoendopeptidase f FORC47_3361 ENOG4105FFC UPF0187 protein FORC47_3364 ENOG4108A04 Beta-lactamase FORC47_3369 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FORC47_3372 ENOG41082BM Transcriptional regulator, arsr family FORC47_3373 ENOG4105CIS alcohol dehydrogenase FORC47_3374 ENOG4105CNG UPF0061 protein FORC47_3378 ENOG4105RHY Pfam:UPF0157 FORC47_3381 ENOG4105CQB FAD linked oxidase domain protein FORC47_3385 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FORC47_3387 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FORC47_3388 ENOG4105CEP NADH dehydrogenase FORC47_3390 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C FORC47_3391 ENOG4108M1A Chitin-binding protein FORC47_3394 ENOG4105E1K spore germination protein FORC47_3398 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FORC47_3401 ENOG4108IAJ Nad-dependent epimerase dehydratase FORC47_3402 ENOG4105FAW cDP-glucose 4,6-dehydratase FORC47_3403 ENOG4105D7V transposase FORC47_3415 ENOG4105BZU Histidine kinase FORC47_3416 ENOG4105C5H ABC transporter FORC47_3417 ENOG41067SE Tetr family transcriptional regulator FORC47_3418 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity FORC47_3420 ENOG4108VXD carboxy-peptidase FORC47_3421 ENOG4107DUR UPF0457 protein FORC47_3428 ENOG4105KT7 mgtC SapB transporter FORC47_3430 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FORC47_3431 ENOG41073R8 VanW family FORC47_3433 ENOG4108R1P FORC47_3436 ENOG4105VEQ Cold shock protein FORC47_3440 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FORC47_3444 ENOG410904N short-chain dehydrogenase reductase FORC47_3446 ENOG4106IQC argininosuccinate lyase FORC47_3449 ENOG4108IA2 Sodium pantothenate symporter FORC47_3451 ENOG4105C26 Dehydrogenase FORC47_3452 ENOG4105CHR reductase FORC47_3454 ENOG4105EWU Squalene--hopene cyclase FORC47_3456 ENOG4105FR1 rard protein FORC47_3457 ENOG410696E Membrane FORC47_3460 ENOG4105D1F ATP-binding protein FORC47_3462 ENOG4108ZAF Molybdopterin FORC47_3463 ENOG4105CVM Molybdenum cofactor synthesis domain protein FORC47_3464 ENOG4105D06 uba thif-type nad fad binding protein FORC47_3465 ENOG4105TMB Formate nitrite transporter FORC47_3467 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FORC47_3468 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FORC47_3470 ENOG4108JB9 formate dehydrogenase FORC47_3472 ENOG4105E1K spore germination protein FORC47_3475 ENOG4105CUB amino acid FORC47_3485 ENOG4105DQ6 Transposase FORC47_3488 ENOG4108KGH TRANSCRIPTIONal FORC47_3490 ENOG4105EMN RNA polymerase sigma factor FORC47_3492 ENOG4105CIG ABC transporter FORC47_3496 ENOG4105D9R oxidoreductase FORC47_3498 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FORC47_3499 ENOG4105K4P CoA-binding domain protein FORC47_3500 ENOG4105C0H protease FORC47_3501 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC47_3503 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FORC47_3504 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FORC47_3505 ENOG4105W8X HesB YadR YfhF-family protein FORC47_3512 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FORC47_3513 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC47_3514 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC47_3516 ENOG4108JJA ABC, transporter FORC47_3517 ENOG4108I0Z Aconitate hydratase FORC47_3523 ENOG4105E5W Transporter FORC47_3525 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FORC47_3529 ENOG4107F3J Amp-dependent synthetase and ligase FORC47_3530 ENOG4107ZYJ bioY protein FORC47_3531 ENOG4105CEY Amp-dependent synthetase and ligase FORC47_3534 ENOG4105BZU Histidine kinase FORC47_3537 ENOG4105C19 ABC transporter FORC47_3540 ENOG4105CJ1 ABC, transporter FORC47_3558 ENOG4107AYK membrAne FORC47_3560 ENOG4105BZU Histidine kinase FORC47_3561 ENOG4105FBA Phospholipase Carboxylesterase FORC47_3562 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FORC47_3563 ENOG4105CK7 Sodium proline symporter FORC47_3565 ENOG4105CBC glutamate synthase FORC47_3566 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FORC47_3567 ENOG4108VJ1 Transcriptional regulator (CarD family FORC47_3568 ENOG4108903 Formimidoylglutamase FORC47_3573 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) FORC47_3579 ENOG4107QIV Cytochrome c biogenesis protein FORC47_3582 ENOG4105CH2 amidohydrolase FORC47_3584 ENOG4105CJ1 ABC, transporter FORC47_3587 ENOG4107RSM transcriptional regulator FORC47_3588 ENOG4105VAW lrga family FORC47_3589 ENOG41067MG lrgb family FORC47_3597 ENOG4105BZ1 (ABC) transporter FORC47_3598 ENOG4105BZ1 (ABC) transporter FORC47_3599 ENOG4105BZ1 (ABC) transporter FORC47_3608 ENOG4105CGH 5'-nucleotidase FORC47_3610 ENOG4108SVB resolvase FORC47_3614 ENOG4105K7K Transcriptional regulator FORC47_3616 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FORC47_3617 ENOG4105DR5 peptidase FORC47_3626 ENOG4105C5F glutamine synthetase FORC47_3627 ENOG4105KV4 Transcriptional regulator FORC47_3628 ENOG4105CXI aluminum resistance protein FORC47_3629 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FORC47_3630 ENOG4105EN6 Membrane FORC47_3632 ENOG4106F1P AAA ATPase, central domain protein FORC47_3636 ENOG4105DQ6 Transposase FORC47_3640 ENOG41069ER domain protein FORC47_3641 ENOG4105DM4 PTS System FORC47_3642 ENOG4105DE4 1-phosphofructokinase FORC47_3643 ENOG4105E98 transcriptional regulator DeoR family FORC47_3644 ENOG4107QW4 alcohol dehydrogenase FORC47_3645 ENOG4108SJC Membrane FORC47_3647 ENOG4105C85 amino acid FORC47_3650 ENOG4105TMB Formate nitrite transporter FORC47_3651 ENOG4105K70 DNA-binding protein FORC47_3653 ENOG4105C59 p-type ATPase FORC47_3654 ENOG410681U heavy metal transport detoxification protein FORC47_3655 ENOG4105VPX protein, conserved in bacteria FORC47_3657 ENOG4105NIV Esterase FORC47_3658 ENOG4105E0A ABC, transporter FORC47_3662 ENOG4105CGK Exodeoxyribonuclease III FORC47_3664 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FORC47_3665 ENOG4105D03 DNA-3-methyladenine glycosylase II FORC47_3666 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FORC47_3671 ENOG4105BZU Histidine kinase FORC47_3675 ENOG4105C5E polysaccharide biosynthesis protein FORC47_3679 ENOG41067MG lrgb family FORC47_3684 ENOG4108S3Y transcriptional regulator FORC47_3685 ENOG4105CS2 ec 3.2.1.21 FORC47_3689 ENOG4105F0V Cell wall hydrolase FORC47_3691 ENOG4105E0M Sulfatase FORC47_3692 ENOG410890F Dynamin family FORC47_3699 ENOG4105DQU oxidoreductase, subunit beta FORC47_3700 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FORC47_3701 ENOG4108IGT Dipeptidase FORC47_3702 ENOG4105MCT stage V sporulation protein S FORC47_3703 ENOG4105D48 metallophosphoesterase FORC47_3708 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FORC47_3711 ENOG4105XZV Protein of unknown function (DUF3243) FORC47_3712 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FORC47_3716 ENOG4105UIB (ABC) transporter FORC47_3717 ENOG4108JQ9 ABC transporter FORC47_3718 ENOG4105DIH basic membrane FORC47_3719 ENOG4105FDP GntR family transcriptional regulator FORC47_3721 ENOG4105CNU cell division protein FtsK FORC47_3723 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FORC47_3725 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FORC47_3727 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FORC47_3728 ENOG4108S0H Dipicolinic acid synthetase, b subunit FORC47_3729 ENOG4105E35 Dipicolinate synthase subunit A FORC47_3731 ENOG4105C1V Peptidase, M16 FORC47_3735 ENOG4105DTN riboflavin biosynthesis protein ribF FORC47_3738 ENOG4105W7A Protein of unknown function (DUF503) FORC47_3740 ENOG4105VHM ribosomal protein FORC47_3741 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FORC47_3742 ENOG4105CHV Transcription elongation factor NusA FORC47_3744 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FORC47_3746 ENOG4105DZP Membrane-associated zinc metalloprotease FORC47_3747 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FORC47_3748 ENOG4105KNE Phosphatidate cytidylyltransferase FORC47_3749 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FORC47_3757 ENOG4108HE4 integrase family FORC47_3759 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FORC47_3760 ENOG4105C79 DNA protecting protein DprA FORC47_3761 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FORC47_3764 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FORC47_3769 ENOG4105VB6 UPF0109 protein FORC47_3773 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FORC47_3774 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FORC47_3777 ENOG4105CHR reductase FORC47_3778 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FORC47_3781 ENOG4105CB5 ATP-dependent DNA helicase recG FORC47_3782 ENOG4105DP4 dak2 domain fusion protein ylov FORC47_3783 ENOG4108ZAA Alkaline-shock protein FORC47_3785 ENOG4105FJ0 thiamine FORC47_3786 ENOG4105DJV ribulose-phosphate 3-epimerase FORC47_3787 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FORC47_3788 ENOG4105D9P serine threonine protein kinase FORC47_3789 ENOG4108ZF3 Phosphatase FORC47_3791 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FORC47_3794 ENOG4105C25 Primosomal protein n' FORC47_3795 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FORC47_3799 ENOG4105DSJ YicC domain protein FORC47_3801 ENOG4105F23 Fibronectin-binding protein FORC47_3803 ENOG4105DC7 peptidase M24 FORC47_3813 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) FORC47_3820 ENOG4105C34 Pseudouridine synthase FORC47_3823 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FORC47_3825 ENOG4105DBK s4 domain protein FORC47_3826 ENOG41067XK integral membrane protein FORC47_3828 ENOG4105DFA alanine racemase domain protein FORC47_3829 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FORC47_3830 ENOG4105WR5 sporulation protein, YlmC YmxH family FORC47_3832 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC47_3834 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FORC47_3835 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FORC47_3836 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FORC47_3838 ENOG4105D4A Cell wall formation (By similarity) FORC47_3839 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FORC47_3840 ENOG4105CNI cell division protein FtsW FORC47_3843 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FORC47_3844 ENOG4105CJN penicillin-binding protein FORC47_3845 ENOG4105CJN penicillin-binding protein FORC47_3848 ENOG41074B2 UPF0747 protein FORC47_3853 ENOG4105KNH Nucleic acid-binding protein FORC47_3855 ENOG41063PX domain protein FORC47_3856 ENOG4105D78 K07001 NTE family protein FORC47_3857 ENOG4105H20 Sporulation integral membrane protein YlbJ FORC47_3859 ENOG4106H78 methyltransferase FORC47_3863 ENOG4107TB6 phosphoglycerate mutase FORC47_3866 ENOG4106UY4 Inherit from COG: Scp-like extracellular FORC47_3872 ENOG4105BZ9 Cytochrome C oxidase, subunit I FORC47_3876 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FORC47_3877 ENOG4105CNI cell division protein FtsW FORC47_3880 ENOG4108IAB Phoh family FORC47_3884 ENOG4105QA2 FORC47_3885 ENOG4105CI3 gtp-binding protein typa FORC47_3887 ENOG4105ECY inositol monophosphatase FORC47_3891 ENOG4105CXN decarboxylase FORC47_3901 ENOG4105CPP Dehydrogenase, E1 component FORC47_3904 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FORC47_3905 ENOG4108X4Q Hydrolase FORC47_3907 ENOG4105CN5 Metallo-Beta-Lactamase FORC47_3908 ENOG4107ZYR domain protein FORC47_3915 ENOG4108XRC Protein of unknown function (DUF458) FORC47_3917 ENOG4107IN1 Protein of unknown function (DUF1797) FORC47_3920 ENOG4105EPM Diguanylate phosphodiesterase FORC47_3921 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FORC47_3924 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FORC47_3926 ENOG4105UIN FORC47_3934 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FORC47_3938 ENOG4108HGU Histidine kinase FORC47_3940 ENOG4105CHM Aminotransferase FORC47_3941 ENOG4105FKQ transcriptional regulator FORC47_3942 ENOG4105EG2 ABC transporter, permease FORC47_3944 ENOG4107FKK extracellular solute-binding protein family 1 FORC47_3946 ENOG4105CG3 alpha amylase, catalytic region FORC47_3955 ENOG4105CHU acetyl-coa acetyltransferase FORC47_3961 ENOG4105K7K Transcriptional regulator FORC47_3962 ENOG4105DTD Dehydrogenase FORC47_3966 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FORC47_3971 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FORC47_3974 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FORC47_3976 ENOG4105BZU Histidine kinase FORC47_3980 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FORC47_3983 ENOG4105CID antiterminator FORC47_3985 ENOG4105FDP GntR family transcriptional regulator FORC47_3987 ENOG4105CE4 GlcNAc 6-P deacetylase FORC47_3993 ENOG4107ZE5 PPIases accelerate the folding of proteins FORC47_3994 ENOG4105PTM secreted protein FORC47_3995 ENOG4105J7I hydrolase FORC47_3997 ENOG4105G6R Stage v sporulation protein ae FORC47_3999 ENOG4105CZ3 stage V sporulation protein ad FORC47_4000 ENOG41090VF Stage v sporulation protein ac FORC47_4003 ENOG4105C8J )-transporter FORC47_4004 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC47_4006 ENOG41082AN stage II sporulation protein FORC47_4007 ENOG4105DZ1 carboxypeptidase FORC47_4008 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FORC47_4009 ENOG4105DVE abc transporter atp-binding protein FORC47_4016 ENOG4105D7N magnesium and cobalt transport protein CorA FORC47_4021 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FORC47_4023 ENOG4105I3K Ferric uptake regulator, Fur family FORC47_4024 ENOG4105MZ9 stage II sporulation protein m FORC47_4028 ENOG4105CPC Aldo Keto reductase FORC47_4029 ENOG4105CV8 reductase FORC47_4030 ENOG4105RHY Pfam:UPF0157 FORC47_4034 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FORC47_4036 ENOG4105ETE Transcriptional regulator (LacI family FORC47_4037 ENOG4108YM7 Gcn5-related n-acetyltransferase FORC47_4041 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FORC47_4042 ENOG4108R6K riboflavin synthase, subunit alpha FORC47_4047 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FORC47_4050 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FORC47_4053 ENOG4105DFD Na H antiporter FORC47_4054 ENOG4105CGH 5'-nucleotidase FORC47_4059 ENOG4105DBV ornithine carbamoyltransferase FORC47_4062 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FORC47_4065 ENOG4108IXY short-chain dehydrogenase reductase FORC47_4066 ENOG41069FQ Metallo-beta-lactamase superfamily FORC47_4067 ENOG4105II7 pyrroline-5-carboxylate reductase FORC47_4068 ENOG4105EJQ L-serine dehydratase FORC47_4074 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FORC47_4077 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FORC47_4078 ENOG4105D9U N-acetyltransferase FORC47_4080 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FORC47_4081 ENOG4108QEG Membrane FORC47_4082 ENOG4105CDA abc transporter atp-binding protein FORC47_4083 ENOG4105E5Q amino acid AbC transporter FORC47_4084 ENOG4108HW3 (ABC) transporter FORC47_4086 ENOG4105G7B Protein of unknown function (DUF2992) FORC47_4088 ENOG4108QY0 Membrane FORC47_4090 ENOG4105C7S Dehydrogenase FORC47_4091 ENOG4105CPP Dehydrogenase, E1 component FORC47_4095 ENOG4107RDP Dehydrogenase FORC47_4097 ENOG4108JUB Transcriptional regulator FORC47_4099 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FORC47_4102 ENOG4107QQR Sporulation FORC47_4103 ENOG4105S1Z Stage IV sporulation protein B FORC47_4104 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FORC47_4105 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FORC47_4106 ENOG4105DX0 Hemolysin A FORC47_4109 ENOG4105CTB Polyprenyl synthetase FORC47_4112 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FORC47_4114 ENOG4108ZSR alkaline shock protein FORC47_4115 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FORC47_4119 ENOG410644B Stage III sporulation protein af FORC47_4121 ENOG4105KQ4 Stage iii sporulation protein ad FORC47_4122 ENOG4108CQH stage III sporulation protein AC FORC47_4123 ENOG4105KR5 Stage iii sporulation protein FORC47_4124 ENOG4105CD2 stage iii sporulation protein aa FORC47_4129 ENOG4105DC7 peptidase M24 FORC47_4130 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FORC47_4132 ENOG4105CBJ Metal-dependent enzyme FORC47_4134 ENOG4107YBY Hydrolase FORC47_4140 ENOG41082GG biotin lipoate A B protein ligase FORC47_4141 ENOG4105WZW rhodanese family FORC47_4146 ENOG41080TC multidrug resistance protein FORC47_4154 ENOG4105CJ1 ABC, transporter FORC47_4155 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FORC47_4158 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FORC47_4162 ENOG4105C0D helicase FORC47_4179 ENOG4107R6U sodium dicarboxylate symporter FORC47_4187 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FORC47_4188 ENOG4105C3R Methionine synthase FORC47_4191 ENOG4105C28 cystathionine FORC47_4192 ENOG4105C28 cystathionine FORC47_4196 ENOG4105C5X domain protein FORC47_4198 ENOG4105DKQ ROK family FORC47_4200 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FORC47_4203 ENOG4108UTW Plays a role in the regulation of phosphate uptake FORC47_4204 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FORC47_4205 ENOG4105C8U phosphate abc transporter FORC47_4206 ENOG4105C8U phosphate abc transporter FORC47_4207 ENOG4105EXS phosphate abc transporter FORC47_4208 ENOG4107RF6 penicillin-binding protein FORC47_4210 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FORC47_4214 ENOG4105N80 Ferric uptake regulator, Fur family FORC47_4216 ENOG4105FDK ABC transporter FORC47_4217 ENOG4108JYZ YitT family FORC47_4218 ENOG41069ZM Protein of unknown function (DUF2624) FORC47_4223 ENOG4105EGD dinuclear metal center protein, YbgI family FORC47_4226 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC47_4227 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FORC47_4235 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FORC47_4236 ENOG4105KG3 cytidine deaminase FORC47_4237 ENOG4107YR5 Diacylglycerol kinase FORC47_4238 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FORC47_4239 ENOG4105CTJ Metal Dependent Phosphohydrolase FORC47_4240 ENOG4105C9A Phoh family FORC47_4242 ENOG41068P3 sporulation protein YqfC FORC47_4244 ENOG4105KTH gatB Yqey FORC47_4246 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FORC47_4247 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FORC47_4251 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FORC47_4253 ENOG4105CSA Coproporphyrinogen iii oxidase FORC47_4254 ENOG4105KVH Transcriptional regulator FORC47_4259 ENOG4105TQK DNA polymerase iii, delta' subunit FORC47_4261 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FORC47_4262 ENOG4108UK2 deaminase FORC47_4263 ENOG4105KQC Competence protein FORC47_4265 ENOG4105DXX methyltransferase FORC47_4267 ENOG4108WF2 Metal Dependent Phosphohydrolase FORC47_4269 ENOG410812S Rna-binding protein FORC47_4271 ENOG4105CQW ribosome biogenesis GTPase YqeH FORC47_4272 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FORC47_4275 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC47_4278 ENOG4108TVJ Nitroreductase FORC47_4281 ENOG4105G6Z alkaline phosphatase FORC47_4282 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FORC47_4283 ENOG4108MUZ hydrolase FORC47_4290 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FORC47_4292 ENOG4105MIR Phenylalanine 4-monooxygenase FORC47_4294 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FORC47_4302 ENOG4105S6R Iron-hydroxamate transporter permease subunit FORC47_4303 ENOG4108V5C ABC transporter FORC47_4305 ENOG4108EKI Dehydrogenase FORC47_4306 ENOG4105C28 cystathionine FORC47_4312 ENOG4107XRG penicillin-binding protein FORC47_4313 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FORC47_4315 ENOG4105CFP Peptidase U32 FORC47_4316 ENOG4105XYU peptidase (U32 family) FORC47_4317 ENOG4108VQJ O-methyltransferase FORC47_4318 ENOG4105HHA aminodeoxychorismate lyase FORC47_4322 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FORC47_4324 ENOG4105C02 permease FORC47_4327 ENOG41060CR FORC47_4328 ENOG4105C7H Helicase, RecD TraA family FORC47_4330 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FORC47_4331 ENOG4105C3J Cysteine desulfurase FORC47_4334 ENOG4105D1H recombination factor protein RarA FORC47_4335 ENOG4108VCI transcription factor, rsfa family FORC47_4336 ENOG4105CUZ uba thif-type nad fad binding protein FORC47_4338 ENOG4105CUT histidyl-tRNA synthetase FORC47_4340 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FORC47_4341 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FORC47_4343 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FORC47_4344 ENOG41076HS cation diffusion facilitator family transporter FORC47_4345 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FORC47_4347 ENOG4105CKP Polysaccharide Biosynthesis Protein FORC47_4348 ENOG4108QG2 Membrane FORC47_4350 ENOG4105VIE preprotein translocase, subunit YajC FORC47_4353 ENOG41061AI Protein of unknown function (DUF2905) FORC47_4356 ENOG4108HUF Transporter FORC47_4362 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FORC47_4363 ENOG4108IYU L-aspartate oxidase FORC47_4366 ENOG4108RPX mosc domain containing protein FORC47_4367 ENOG4105CQC Prephenate dehydratase FORC47_4370 ENOG4105C19 ABC transporter FORC47_4371 ENOG4105EWM Histidine kinase FORC47_4373 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FORC47_4376 ENOG4105X36 (ribosomal) protein FORC47_4378 ENOG4105C03 ribonuclease FORC47_4381 ENOG4107QMS site-determining protein FORC47_4384 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FORC47_4385 ENOG4105DFF Rod shape-determining protein mreb FORC47_4389 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FORC47_4390 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FORC47_4392 ENOG41068KH stage VI sporulation protein D FORC47_4394 ENOG4105D52 delta-aminolevulinic acid dehydratase FORC47_4399 ENOG4105K56 Transcriptional regulator FORC47_4403 ENOG4108IUQ atp-dependent protease FORC47_4408 ENOG4108QCI YvbH-like oligomerisation region FORC47_4411 ENOG4105M59 Phosphodiesterase, mj0936 family FORC47_4414 ENOG4108XJQ germination protein FORC47_4416 ENOG4108PCX Major Facilitator FORC47_4418 ENOG4105KBX Transcriptional regulator, TetR family FORC47_4420 ENOG4105PFC Transcriptional regulator FORC47_4422 ENOG4105DZC cytosine deaminase FORC47_4423 ENOG41067S9 phage shock protein C, PspC FORC47_4424 ENOG4108JCI Transcriptional regulator FORC47_4426 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FORC47_4427 ENOG4108Z40 Transcriptional regulator FORC47_4428 ENOG4105RHA ABC transporter, permease FORC47_4429 ENOG4108IUX (ABC) transporter FORC47_4430 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FORC47_4431 ENOG4105ER2 Ompa motb domain protein FORC47_4432 ENOG4105E14 MotA TolQ exbB proton channel FORC47_4433 ENOG4108VXD carboxy-peptidase FORC47_4435 ENOG4105E33 succinate dehydrogenase FORC47_4437 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FORC47_4439 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FORC47_4440 ENOG4105K63 Thioredoxin FORC47_4441 ENOG4105C10 Electron transfer flavoprotein FORC47_4442 ENOG4105BZJ Electron transfer flavoprotein FORC47_4443 ENOG41060WC Enoyl-CoA hydratase FORC47_4444 ENOG4107Z3H Transcriptional regulator, TetR family FORC47_4445 ENOG4105CEY Amp-dependent synthetase and ligase FORC47_4458 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC47_4461 ENOG4105DR4 Methyltransferase FORC47_4463 ENOG4105KFN sortase, SrtB family FORC47_4464 ENOG4105E0A ABC, transporter FORC47_4467 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FORC47_4469 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FORC47_4471 ENOG4105FE9 pseudouridine synthase FORC47_4473 ENOG4105DCG PHP domain protein FORC47_4476 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FORC47_4478 ENOG4105C5S asparaginyl-tRNA synthetase FORC47_4479 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FORC47_4481 ENOG4108RWN rrna methyltransferase FORC47_4487 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC47_4488 ENOG4105CW7 secretion protein, HlyD family FORC47_4489 ENOG4108JGH Tetr family transcriptional regulator FORC47_4490 ENOG4105CN9 Peptidase m42 family protein FORC47_4494 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FORC47_4495 ENOG4105C22 threonyL-tRNA synthetase FORC47_4496 ENOG4108TDW sporulation protein YtxC FORC47_4501 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FORC47_4503 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FORC47_4504 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FORC47_4506 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FORC47_4507 ENOG4105C2M dna polymerase I FORC47_4508 ENOG4105BZU Histidine kinase FORC47_4509 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC47_4514 ENOG4108HMX isocitrate dehydrogenase (NADP) FORC47_4515 ENOG4105BZN citrate synthase FORC47_4517 ENOG4108REF Sporulation integral membrane protein ytvi FORC47_4518 ENOG4105FS0 cytoplasmic membrane protein FORC47_4523 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FORC47_4524 ENOG4105C6K Malic enzyme FORC47_4525 ENOG4105C0B DNA polymerase III (alpha subunit) FORC47_4526 ENOG4105VV2 FORC47_4528 ENOG4105SFS phosphoesterase RecJ domain protein FORC47_4535 ENOG4105DC7 peptidase M24 FORC47_4543 ENOG4105Z7P Acetyltransferase (GNAT) family FORC47_4544 ENOG41082W1 Cupin 2, conserved barrel domain protein FORC47_4548 ENOG4107YZX Universal stress protein FORC47_4549 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase FORC47_4556 ENOG4108JYZ YitT family FORC47_4560 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FORC47_4562 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FORC47_4563 ENOG4105KBJ sporulation protein ytfj FORC47_4566 ENOG4105EFZ amidohydrolase FORC47_4568 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FORC47_4575 ENOG4105U5Y Transcriptional regulator FORC47_4577 ENOG4105C28 cystathionine FORC47_4583 ENOG4105EMN RNA polymerase sigma factor FORC47_4585 ENOG4108UW5 maltose o-acetyltransferase FORC47_4587 ENOG4105F1V Acetoin utilization protein FORC47_4588 ENOG4105W87 Cbs domain FORC47_4589 ENOG4105DGU Histone deacetylase FORC47_4592 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC47_4593 ENOG4105BZU Histidine kinase FORC47_4594 ENOG4107SNB ankyrin repeat protein YahD FORC47_4595 ENOG4105EP9 oxidoreductase FORC47_4600 ENOG4105ETE Transcriptional regulator (LacI family FORC47_4601 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FORC47_4602 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FORC47_4603 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FORC47_4604 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FORC47_4608 ENOG4105C88 aminopeptidase FORC47_4613 ENOG4105K7K Transcriptional regulator FORC47_4620 ENOG4108VDD TRNA binding domain protein FORC47_4626 ENOG4105C8F Beta-lactamase domain protein FORC47_4629 ENOG4108V15 phosphotransferase enzyme family FORC47_4630 ENOG4108IUM Glycogen debranching enzyme FORC47_4632 ENOG4107QSE Dipeptidase FORC47_4633 ENOG4105YW5 deoR family transcriptional regulator FORC47_4636 ENOG4105CBX hi0933 family FORC47_4643 ENOG4108VJ1 Transcriptional regulator (CarD family FORC47_4644 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FORC47_4645 ENOG4105CSC Glucose uptake protein FORC47_4648 ENOG4108ZAF Molybdopterin FORC47_4649 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FORC47_4650 ENOG4105CVM Molybdenum cofactor synthesis domain protein FORC47_4652 ENOG4105D06 uba thif-type nad fad binding protein FORC47_4653 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FORC47_4657 ENOG41085GJ domain protein FORC47_4659 ENOG4105DWV Homoserine O-trans-acetylase FORC47_4661 ENOG4108B31 Spore germination protein FORC47_4666 ENOG4105C8T Leucyl-tRNA synthetase FORC47_4667 ENOG410605W Major Facilitator FORC47_4668 ENOG4107S91 Sodium hydrogen exchanger FORC47_4669 ENOG4105NCW Trka-c domain protein FORC47_4672 ENOG4105C19 ABC transporter FORC47_4676 ENOG4105N5T Radical SAM Protein FORC47_4681 ENOG4105E8V Alpha Beta Hydrolase Fold protein FORC47_4682 ENOG4108Z0R Transferase FORC47_4683 ENOG4105YVM Phosphoesterase, PA-phosphatase related FORC47_4684 ENOG4105BZF Glycosyl transferase (Group 1 FORC47_4686 ENOG4108RIR Molybdenum cofactor biosynthesis protein FORC47_4705 ENOG4105BZU Histidine kinase FORC47_4706 ENOG4105BZU Histidine kinase FORC47_4707 ENOG4105CH6 catalase FORC47_4708 ENOG4107S9D Alpha beta hydrolase FORC47_4709 ENOG4107T7U Sulfatase FORC47_4713 ENOG4105D2X ABC transporter substrate-binding protein FORC47_4715 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FORC47_4728 ENOG4108V2W Carbonate dehydratase FORC47_4729 ENOG4105C4M (Ubiquinol oxidase) subunit I FORC47_4730 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FORC47_4739 ENOG41087YS Phage shock protein A FORC47_4744 ENOG4105N67 Proton-coupled thiamine transporter YuaJ FORC47_4745 ENOG4105BZU Histidine kinase FORC47_4746 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC47_4751 ENOG4108UGV hypoxanthine phosphoribosyltransferase FORC47_4752 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FORC47_4765 ENOG4107ZTW SNARE associated Golgi FORC47_4768 ENOG4105C19 ABC transporter FORC47_4769 ENOG41086D8 Transcriptional regulator FORC47_4772 ENOG41082BM Transcriptional regulator, arsr family FORC47_4782 ENOG4105C6Z Gluconate FORC47_4784 ENOG4105FDP GntR family transcriptional regulator FORC47_4788 ENOG41069H0 dihydroorotase EC 3.5.2.3 FORC47_4792 ENOG4105DTQ mandelate racemase muconate lactonizing FORC47_4793 ENOG4105CEY Amp-dependent synthetase and ligase FORC47_4794 ENOG4108IPT Naphthoate synthase FORC47_4795 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FORC47_4796 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FORC47_4797 ENOG4105E4F Isochorismate synthase FORC47_4798 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FORC47_4800 ENOG4105VEQ Cold shock protein FORC47_4809 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FORC47_4810 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FORC47_4812 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FORC47_4814 ENOG4105KT7 mgtC SapB transporter FORC47_4815 ENOG4107PBV potassium channel FORC47_4818 ENOG4105WG9 Conserved Protein FORC47_4820 ENOG4105CHM Aminotransferase FORC47_4821 ENOG4108ZB6 transcriptional regulator AsnC family FORC47_4822 ENOG4105C5I Dehydrogenase FORC47_4823 ENOG4108MUZ hydrolase FORC47_4825 ENOG4105C87 Aminotransferase class I and II FORC47_4828 ENOG4105Y38 Kinase-associated protein B FORC47_4830 ENOG4107R3E Citrate transporter FORC47_4833 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FORC47_4834 ENOG4105KA0 thioesterase Superfamily protein FORC47_4837 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FORC47_4842 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) FORC47_4843 ENOG4106YN8 Prenyltransferase FORC47_4846 ENOG41069ER domain protein FORC47_4849 ENOG4105CEP NADH dehydrogenase FORC47_4855 ENOG4105EWC Purine nucleoside phosphorylase FORC47_4857 ENOG4108VQJ O-methyltransferase FORC47_4859 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FORC47_4864 ENOG4108JJA ABC, transporter FORC47_4865 ENOG4105C4B ABC transporter, permease FORC47_4866 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FORC47_4878 ENOG41083MR nifu domain-containing protein FORC47_4881 ENOG4108W5N phosphatidylglycerophosphatase a FORC47_4885 ENOG4105DAX Pfam:DUF2983 FORC47_4887 ENOG4105DYS nad(p)h dehydrogenase (quinone) FORC47_4888 ENOG4105D4U had-superfamily hydrolase, subfamily iia FORC47_4891 ENOG4105CBT Fructose-1,6-bisphosphatase FORC47_4894 ENOG4105MMD transcriptional regulator FORC47_4895 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FORC47_4896 ENOG4107TXC Transcriptional regulator FORC47_4897 ENOG41090T1 Membrane FORC47_4902 ENOG4105FAA peptidase M23 FORC47_4903 ENOG4108YTE sporulation protein YunB FORC47_4904 ENOG4105KZD Domain of unknown function (DUF1805) FORC47_4905 ENOG4107R8B 5'-nucleotidase FORC47_4906 ENOG4105DIW FeS assembly protein SUFB FORC47_4907 ENOG4108UNV SUF system FeS assembly protein, NifU family FORC47_4908 ENOG4105C9B Cysteine desulfurase FORC47_4909 ENOG4105JRK feS assembly protein SufD FORC47_4910 ENOG4105C3K feS assembly ATPase SufC FORC47_4911 ENOG4105D01 (LipO)protein FORC47_4912 ENOG4105D01 (LipO)protein FORC47_4913 ENOG4108UMI ABC transporter, permease FORC47_4914 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FORC47_4919 ENOG41080E8 Transcriptional regulator, Spx MgsR family FORC47_4924 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FORC47_4930 ENOG4108W8B Beta-lactamase domain protein FORC47_4931 ENOG4105C1G acyl-Coa dehydrogenase FORC47_4932 ENOG4105CHU acetyl-coa acetyltransferase FORC47_4935 ENOG4105DZ1 carboxypeptidase FORC47_4939 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FORC47_4942 ENOG4108SUT Major Facilitator Superfamily FORC47_4943 ENOG4107R7I amino acid FORC47_4946 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FORC47_4948 ENOG4107AYK membrAne FORC47_4956 ENOG4107ZTW SNARE associated Golgi FORC47_4958 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FORC47_4959 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC47_4960 ENOG4105BZU Histidine kinase FORC47_4965 ENOG4105C8Q Methyl-accepting chemotaxis FORC47_4966 ENOG4105C8Q Methyl-accepting chemotaxis FORC47_4967 ENOG4105VG1 fes assembly suf system protein FORC47_4968 ENOG4105D4Y metalloprotease FORC47_4969 ENOG4105C2I pirin domain protein FORC47_4972 ENOG4107T5V SNARE associated Golgi FORC47_4973 ENOG4107S91 Sodium hydrogen exchanger FORC47_4974 ENOG4105NCW Trka-c domain protein FORC47_4977 ENOG4108RMU ferritin dps family protein FORC47_4981 ENOG4108URH decarboxylase FORC47_4983 ENOG41090A1 ferritin FORC47_4984 ENOG4105DHF Membrane FORC47_4985 ENOG4105D9N nucleoside FORC47_4986 ENOG4105D9N nucleoside FORC47_4989 ENOG4108RYK Nad-dependent epimerase dehydratase FORC47_4992 ENOG4105CV8 reductase FORC47_4993 ENOG4105F27 Major Facilitator FORC47_4994 ENOG4105KVH Transcriptional regulator FORC47_4997 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FORC47_4998 ENOG4105D4A Cell wall formation (By similarity) FORC47_5002 ENOG4105WMR Protein CrcB homolog FORC47_5003 ENOG4105WMR Protein CrcB homolog FORC47_5007 ENOG4105C5H ABC transporter FORC47_5008 ENOG4108MK9 spermidine N(1)-acetyltransferase FORC47_5009 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FORC47_5015 ENOG4108IPW abc transporter atp-binding protein FORC47_5016 ENOG4105CM4 permease protein FORC47_5021 ENOG4105EYF MMPL domain protein FORC47_5023 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FORC47_5025 ENOG4105XZU Preprotein translocase, subunit SecG FORC47_5026 ENOG41067MG lrgb family FORC47_5036 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC47_5037 ENOG4105RHA ABC transporter, permease FORC47_5038 ENOG4108IUX (ABC) transporter FORC47_5039 ENOG4105BZU Histidine kinase FORC47_5040 ENOG4108W5X Transcriptional Regulator, LuxR family FORC47_5043 ENOG41090VF Stage v sporulation protein ac FORC47_5044 ENOG4105CZ3 stage V sporulation protein ad FORC47_5047 ENOG4108QY0 Membrane FORC47_5048 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FORC47_5049 ENOG4105KRI phosphocarrier protein (HPr FORC47_5051 ENOG4105CHW UPF0052 protein FORC47_5052 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FORC47_5053 ENOG4108Z4K mutator MutT protein FORC47_5055 ENOG4105C3M thioredoxin reductase FORC47_5057 ENOG4108S4C acetyltransferase FORC47_5061 ENOG41086DT Membrane protein of unknown function FORC47_5063 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FORC47_5067 ENOG4107TXC Transcriptional regulator FORC47_5071 ENOG4105DUM transcriptional regulator, lysR family FORC47_5073 ENOG4108WS4 fmn reductase FORC47_5076 ENOG4105BZ1 (ABC) transporter FORC47_5078 ENOG4105CN1 protease FORC47_5079 ENOG4105CRP Part of the ABC transporter FtsEX involved in FORC47_5080 ENOG4105CAK Cell division ATP-binding protein ftsE FORC47_5083 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) FORC47_5085 ENOG4105MS2 ribosomal subunit Interface protein FORC47_5087 ENOG4105VEQ Cold shock protein FORC47_5088 ENOG4105MJ2 Competence protein FORC47_5089 ENOG41081UC Inherit from COG: Competence protein FORC47_5093 ENOG4105KVH Transcriptional regulator FORC47_5095 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FORC47_5096 ENOG4108KGH TRANSCRIPTIONal FORC47_5097 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FORC47_5098 ENOG4105C6Y Udp-glucose 6-dehydrogenase FORC47_5100 ENOG4105ESV Glycosyl transferase, family 4 FORC47_5102 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FORC47_5106 ENOG4105F8D glycoside hydrolase family 4 FORC47_5107 ENOG4105VCP PTS System FORC47_5108 ENOG4105CK1 PTS System FORC47_5110 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FORC47_5112 ENOG4105VCP PTS System FORC47_5114 ENOG4105VZJ PTS System FORC47_5118 ENOG4105ECB domain protein FORC47_5119 ENOG4107RSM transcriptional regulator FORC47_5131 ENOG4105DAA L-lactate FORC47_5133 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FORC47_5135 ENOG4105E0M Sulfatase FORC47_5140 ENOG4107R8N Glycosyl transferase, family 2 FORC47_5142 ENOG4105C94 Transporter FORC47_5143 ENOG41069ER domain protein FORC47_5148 ENOG4105KBK Zinc finger, swim domain protein FORC47_5149 ENOG4105C0D helicase FORC47_5155 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC47_5157 ENOG4107RBB ABC transporter, permease FORC47_5158 ENOG4105C19 ABC transporter FORC47_5162 ENOG4105CXY transporter FORC47_5165 ENOG4105BZU Histidine kinase FORC47_5166 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC47_5167 ENOG4105CMR udp-glucose 4-epimerase FORC47_5169 ENOG4108KGH TRANSCRIPTIONal FORC47_5171 ENOG4105C6Y Udp-glucose 6-dehydrogenase FORC47_5178 ENOG4107T8Q Glycosyl transferase (Group 1 FORC47_5179 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FORC47_5181 ENOG4105C5E polysaccharide biosynthesis protein FORC47_5183 ENOG4105D7W serine acetyltransferase FORC47_5184 ENOG4105D3Q Sugar transferase FORC47_5185 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FORC47_5187 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FORC47_5188 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FORC47_5189 ENOG4107YJ4 chain length determinant protein FORC47_5190 ENOG4105HTX biosynthesis protein FORC47_5191 ENOG4107YJ4 chain length determinant protein FORC47_5194 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FORC47_5196 ENOG4105FRN stage II sporulation protein FORC47_5199 ENOG4105DY9 regulatoR FORC47_5203 ENOG4106778 Protein of unknown function (DUF1146) FORC47_5204 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FORC47_5205 ENOG4105C8S subunit m FORC47_5206 ENOG4105D65 subunit l FORC47_5211 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FORC47_5212 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FORC47_5214 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FORC47_5215 ENOG4105BZU Histidine kinase FORC47_5225 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FORC47_5226 ENOG41062M3 atp synthase FORC47_5229 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FORC47_5230 ENOG4108UIC UPF0340 protein FORC47_5231 ENOG4108YZG isomerase FORC47_5234 ENOG4108VGI doxx family FORC47_5235 ENOG4107XC4 flavin reductase domain protein, FMN-binding FORC47_5239 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FORC47_5241 ENOG4108ZXQ stage ii sporulation protein r FORC47_5242 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FORC47_5243 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FORC47_5246 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FORC47_5247 ENOG4105CBT Fructose-1,6-bisphosphatase FORC47_5248 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FORC47_5255 ENOG4105C1G acyl-Coa dehydrogenase FORC47_5256 ENOG4105C1G acyl-Coa dehydrogenase FORC47_5257 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FORC47_5259 ENOG4105DF6 Fe-S oxidoreductase FORC47_5262 ENOG4105BZU Histidine kinase FORC47_5265 ENOG4105D4Y metalloprotease FORC47_5267 ENOG4105BZU Histidine kinase FORC47_5268 ENOG4105KCT ABC transporter FORC47_5269 ENOG4108M15 ABC transporter FORC47_5270 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FORC47_5272 ENOG4105IIU Aminopeptidase FORC47_5276 ENOG4105EMN RNA polymerase sigma factor FORC47_5278 ENOG410684U Domain of unknown function (DUF1934) FORC47_5283 ENOG4105CYW agmatinase FORC47_5285 ENOG4105DXB Major Facilitator superfamily FORC47_5286 ENOG4107SWG transcriptional regulator MERR family FORC47_5287 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FORC47_5288 ENOG4105BZ4 penicillin-binding protein FORC47_5289 ENOG4108XFG YwhD family FORC47_5290 ENOG4108Z4T Peptidase M50 FORC47_5291 ENOG41069HH 4-oxalocrotonate tautomerase FORC47_5292 ENOG4105DCI Phosphohydrolase FORC47_5293 ENOG4108MES Periplasmic binding protein FORC47_5294 ENOG4105E0A ABC, transporter FORC47_5295 ENOG4105EHG Permease protein FORC47_5296 ENOG4105DQ5 transport system permease protein FORC47_5298 ENOG4108VCI transcription factor, rsfa family FORC47_5299 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) FORC47_5300 ENOG4108IJ2 phosphate acetyltransferase FORC47_5301 ENOG4107UEZ chlorite dismutase FORC47_5303 ENOG4108VKI Cell wall hydrolase FORC47_5307 ENOG4107SVH Potassium channel protein FORC47_5309 ENOG410667J hydrolase FORC47_5310 ENOG4105VCH membrane FORC47_5312 ENOG4108TU7 Inherit from COG: (ABC) transporter FORC47_5313 ENOG4105CJ1 ABC, transporter FORC47_5314 ENOG41090WU lipolytic protein G-D-S-L family FORC47_5317 ENOG4105D6E homoserine dehydrogenase FORC47_5318 ENOG4105CVG Homoserine O-transsuccinylase FORC47_5323 ENOG4108Y4K DNA-binding transcriptional activator FORC47_5325 ENOG4105WH1 Two component transcriptional regulator luxr family FORC47_5326 ENOG4105BZU Histidine kinase FORC47_5327 ENOG4105DWF phosphomethylpyrimidine kinase FORC47_5328 ENOG4105BZU Histidine kinase FORC47_5329 ENOG4105VCD cytoplasmic protein FORC47_5330 ENOG4105D22 carbon starvation protein FORC47_5331 ENOG4105DY9 regulatoR FORC47_5332 ENOG41079KZ Major Facilitator Superfamily FORC47_5335 ENOG4105CG5 Glycosyl transferase (Group 1 FORC47_5337 ENOG4105EN6 Membrane FORC47_5338 ENOG4106YBV Methyl-accepting chemotaxis FORC47_5340 ENOG4108S4H thioesterase Superfamily protein FORC47_5341 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) FORC47_5343 ENOG4105K64 Glycosyl transferase, family 2 FORC47_5346 ENOG4108IG5 Transcriptional regulator FORC47_5347 ENOG4105C5H ABC transporter FORC47_5348 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FORC47_5350 ENOG41067SE Tetr family transcriptional regulator FORC47_5352 ENOG4105E0X reductase FORC47_5353 ENOG4106F5Q Membrane FORC47_5356 ENOG4108NEV two component transcriptional regulator, LytTR family FORC47_5357 ENOG4108HRK Histidine kinase FORC47_5358 ENOG4107RGD Major Facilitator superfamily FORC47_5362 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FORC47_5364 ENOG4105IW1 AmiS UreI transporter FORC47_5366 ENOG4105CMR udp-glucose 4-epimerase FORC47_5367 ENOG4108UT2 hemolysin iii FORC47_5369 ENOG4105C1J atp-dependent rna helicase FORC47_5370 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) FORC47_5371 ENOG4105DPN Oligoendopeptidase f FORC47_5373 ENOG4105BZU Histidine kinase FORC47_5376 ENOG4105C0H protease FORC47_5377 ENOG4105Q2H domain protein FORC47_5380 ENOG4105BZU Histidine kinase FORC47_5381 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC47_5382 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FORC47_5383 ENOG4105CDU Replicative dna helicase FORC47_5385 ENOG4105BZR domain protein FORC47_5386 ENOG4108XMW Membrane FORC47_5388 ENOG4108UUM single-stranded DNA-binding protein FORC47_5390 ENOG4105C3G gtp-binding protein FORC47_5391 ENOG4105VDK protein, conserved in bacteria FORC47_5392 ENOG4105D8X mechanosensitive ion channel FORC47_5393 ENOG4108ZDA Sporulation protein YyaC FORC47_5394 ENOG4105FA0 parb-like partition protein FORC47_5395 ENOG4107QJE Chromosome Partitioning Protein FORC47_5398 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FORC47_5399 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FORC47_5401 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FORC47_p003 ENOG4108QY0 Membrane FORC47_p004 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FORC47_p006 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FORC47_p007 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FORC47_p008 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FORC47_p009 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FORC47_p012 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FORC47_p014 ENOG4105CHR reductase FORC47_p015 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FORC47_p017 ENOG4108KYE ABC-2 type transporter FORC47_p018 ENOG4105CJ1 ABC, transporter FORC47_p019 ENOG4105CTC Lipopolysaccharide biosynthesis protein-like protein FORC47_p025 ENOG4105CSV Glutaminase FORC47_p028 ENOG4105D7V transposase FORC47_p029 ENOG4105E1K spore germination protein FORC47_p037 ENOG4107WD8 ABC transporter, permease FORC47_p039 ENOG4105E98 transcriptional regulator DeoR family FORC47_p040 ENOG4107XGZ Hydrolase FORC47_p048 ENOG4105D7V transposase FORC47_p049 ENOG4105DJ2 Major Facilitator Superfamily FORC47_p050 ENOG4108RPX mosc domain containing protein FORC47_p053 ENOG4105CJN penicillin-binding protein FORC47_p056 ENOG4108BUD transposase FORC47_p057 ENOG4105CS2 ec 3.2.1.21 FORC47_p063 ENOG4107RF6 penicillin-binding protein FORC47_p066 ENOG4105E5W Transporter FORC47_p071 ENOG41067QW Transcriptional regulator FORC47_p080 ENOG4105E09 nadh pyrophosphatase FORC47_p086 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FORC47_p143 ENOG4108EKI Dehydrogenase FORC47_p145 ENOG4108EKI Dehydrogenase FORC47_p147 ENOG4108EKI Dehydrogenase FORC47_p148 ENOG4105CUB amino acid FORC47_p155 ENOG4105D7V transposase FORC47_p159 ENOG4105EA8 2-Nitropropane dioxygenase FORC47_p162 ENOG4105D7V transposase FORC47_p166 ENOG4105EA8 2-Nitropropane dioxygenase FORC47_p169 ENOG4105D7V transposase FORC47_p170 ENOG4105BZU Histidine kinase FORC47_p171 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC47_p173 ENOG4105C0H protease FORC47_p175 ENOG4107WD8 ABC transporter, permease FORC47_p178 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FORC47_p188 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FORC47_p190 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC47_p195 ENOG4105CJZ response regulator FORC47_p201 ENOG4105C19 ABC transporter FORC47_p205 ENOG4105KIR Thiol-disulfide oxidoreductase dcc FORC47_p208 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FORC47_p215 ENOG4105BZ4 penicillin-binding protein FORC47_p218 ENOG4105CJW magnesium transporter FORC47_p219 ENOG4105CNI cell division protein FtsW FORC47_p222 ENOG4108IQI permease FORC47_p223 ENOG4108J5H Homocysteine s-methyltransferase FORC47_p228 ENOG4105G9B Transcriptional regulator FORC47_p230 ENOG4105CE7 Amidase, hydantoinase carbamoylase family FORC47_p233 ENOG4105C19 ABC transporter FORC47_p235 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) FORC47_p243 ENOG4105CZV ABC transporter FORC47_p246 ENOG4108ZJ4 polysaccharide deacetylase FORC47_p247 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FORC47_p258 ENOG4105YGK Pfam:UPF0157 FORC47_p262 ENOG4105YGK Pfam:UPF0157 FORC47_p268 ENOG4105YGK Pfam:UPF0157 FORC47_p284 ENOG4107QJE Chromosome Partitioning Protein FORC47_p291 ENOG4107JM4 Tetratricopeptide repeat FORC47_p337 ENOG4105K4H Nlp p60 protein FORC47_p351 ENOG4105C9U ATP-dependent DNA helicase RecQ FORC47_p366 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FORC47_p380 ENOG4108J59 Extracellular solute-binding protein, family 5 FORC47_p402 ENOG4105K4H Nlp p60 protein FORC47_p405 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FORC47_p424 ENOG4105D7V transposase FORC47_p444 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FORC47_p450 ENOG4105CN9 Peptidase m42 family protein FORC47_p457 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FORC47_p485 ENOG4105K4H Nlp p60 protein FORC47_p493 ENOG4105C9U ATP-dependent DNA helicase RecQ