locus-tag class description FORC48_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FORC48_0003 ENOG410848D S4 domain protein YaaA FORC48_0006 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FORC48_0008 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FORC48_0014 ENOG4105ZMH deoxynucleoside kinase FORC48_0016 ENOG4105GTG Isochorismatase FORC48_0017 ENOG4108Z6B deaminase FORC48_0018 ENOG4105C6E dna polymerase iii FORC48_0022 ENOG41067KS pro-sigma K processing FORC48_0024 ENOG4105CXN decarboxylase FORC48_0026 ENOG4105FA2 dna polymerase iii FORC48_0027 ENOG4105MA4 psp1 domain protein FORC48_0029 ENOG41060K3 Methyltransferase FORC48_0031 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FORC48_0032 ENOG4105KRN Transcriptional regulator, abrb family FORC48_0033 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FORC48_0034 ENOG4105F8V Hydrolase, tatD family FORC48_0035 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FORC48_0037 ENOG4105XFA sporulation peptidase YabG FORC48_0038 ENOG4105W42 Veg protein FORC48_0041 ENOG4105DFT pur operon repressor FORC48_0042 ENOG4105KME endoribonuclease L-psp FORC48_0045 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FORC48_0046 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FORC48_0048 ENOG4108JA2 transcriptioN-repair coupling factor FORC48_0049 ENOG4108M14 stage v sporulation protein t FORC48_0051 ENOG4108IY2 MazG family FORC48_0052 ENOG41082I2 s4 domain protein FORC48_0053 ENOG4105VYY sporulation protein yabp FORC48_0056 ENOG41060GV RNA binding s1 domain protein FORC48_0058 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FORC48_0059 ENOG4108UGV hypoxanthine phosphoribosyltransferase FORC48_0060 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FORC48_0063 ENOG4105C6T cysteine synthase FORC48_0065 ENOG4105DDQ anthranilate synthase FORC48_0066 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FORC48_0067 ENOG4105EEI dihydropteroate synthase FORC48_0068 ENOG4105KRF dihydroneopterin aldolase FORC48_0069 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FORC48_0071 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FORC48_0075 ENOG4108Z0C Uvrb UvrC protein FORC48_0078 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FORC48_0080 ENOG4105CTP PilT protein domain protein FORC48_0081 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FORC48_0084 ENOG4105D7W serine acetyltransferase FORC48_0087 ENOG4105C2N RNA methyltransferase TrmH family group 3 FORC48_0088 ENOG4105M0M Tetracycline resistance protein FORC48_0089 ENOG4105QIV RNA polymerase FORC48_0091 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FORC48_0096 ENOG4107Y49 methyltransferase FORC48_0099 ENOG4105XPM ribosomal protein FORC48_0120 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FORC48_0125 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FORC48_0127 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FORC48_0129 ENOG41067V7 50S ribosomal protein L36 FORC48_0134 ENOG4108JJB ABC transporter FORC48_0135 ENOG4108JJB ABC transporter FORC48_0136 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FORC48_0137 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FORC48_0142 ENOG4105D1F ATP-binding protein FORC48_0145 ENOG4108NMV polysaccharide deacetylase FORC48_0149 ENOG4105C8B TIGR00159 family FORC48_0150 ENOG4107U5W ybbr family FORC48_0153 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FORC48_0160 ENOG4108PSK reductase FORC48_0161 ENOG4108UMI ABC transporter, permease FORC48_0162 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FORC48_0163 ENOG4105D01 (LipO)protein FORC48_0165 ENOG4105CB2 alcohol dehydrogenase FORC48_0167 ENOG4105IQ5 FAD linked oxidase domain protein FORC48_0170 ENOG4105C2C drug resistance transporter, Bcr CflA FORC48_0173 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FORC48_0174 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC48_0175 ENOG4105C3U ABC transporter FORC48_0176 ENOG4108JQ7 (ABC) transporter FORC48_0182 ENOG4108J59 Extracellular solute-binding protein, family 5 FORC48_0183 ENOG4108J59 Extracellular solute-binding protein, family 5 FORC48_0187 ENOG4105E0C molybdate abc transporter FORC48_0188 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FORC48_0189 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FORC48_0192 ENOG4105EGI Transcriptional regulator FORC48_0197 ENOG4105F6E Acyl-transferase FORC48_0202 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FORC48_0206 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FORC48_0211 ENOG4105C5H ABC transporter FORC48_0213 ENOG4105DEF Extracellular solute-binding protein, family 5 FORC48_0215 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC48_0216 ENOG4105C3U ABC transporter FORC48_0217 ENOG4108JQ7 (ABC) transporter FORC48_0218 ENOG410667J hydrolase FORC48_0224 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FORC48_0225 ENOG4105ERH Fumarylacetoacetate hydrolase FORC48_0227 ENOG4105CUB amino acid FORC48_0228 ENOG4108SC4 )-transporter FORC48_0229 ENOG4105CPF Cell wall formation (By similarity) FORC48_0230 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FORC48_0235 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FORC48_0236 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FORC48_0238 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FORC48_0242 ENOG4105K8N protein family UPF0079, ATPase FORC48_0243 ENOG41072GX Peptidase M22 Glycoprotease FORC48_0244 ENOG410801F ribosomal-protein-alanine acetyltransferase FORC48_0245 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FORC48_0246 ENOG4105C5H ABC transporter FORC48_0249 ENOG4108TYN CAAX amino terminal protease family protein FORC48_0253 ENOG4105C7N Xanthine uracil vitamin C permease FORC48_0255 ENOG4105BZU Histidine kinase FORC48_0257 ENOG4107ZXU DSBA oxidoreductase FORC48_0262 ENOG4105BZU Histidine kinase FORC48_0263 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC48_0268 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) FORC48_0271 ENOG4105SX7 Transporter FORC48_0274 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FORC48_0275 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FORC48_0276 ENOG4105C83 adenylosuccinate lyase FORC48_0278 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FORC48_0283 ENOG4108V3E phosphoribosylglycinamide formyltransferase FORC48_0285 ENOG4105C12 Phosphoribosylglycinamide synthetase FORC48_0291 ENOG4105C4R Atp-dependent dna helicase FORC48_0296 ENOG4108W2Y isochorismatase FORC48_0297 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FORC48_0298 ENOG4108UMI ABC transporter, permease FORC48_0299 ENOG4105D01 (LipO)protein FORC48_0303 ENOG410834F Transcriptional regulator FORC48_0304 ENOG4107I77 yiaA/B two helix domain FORC48_0308 ENOG4105CBD Diacylglycerol kinase FORC48_0310 ENOG4108JPW Aminotransferase FORC48_0312 ENOG4105C26 Dehydrogenase FORC48_0313 ENOG4105KPY Small multidrug resistance protein FORC48_0319 ENOG4105D9N nucleoside FORC48_0320 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FORC48_0322 ENOG4108W15 Protein of unknown function (DUF1456) FORC48_0325 ENOG4105DTQ mandelate racemase muconate lactonizing FORC48_0327 ENOG4105DFD Na H antiporter FORC48_0331 ENOG4105D3R alkyl hydroperoxide reductase FORC48_0332 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FORC48_0333 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FORC48_0334 ENOG4107W7X Aldolase FORC48_0335 ENOG4105EHG Permease protein FORC48_0336 ENOG4105DQ5 transport system permease protein FORC48_0337 ENOG4108V5C ABC transporter FORC48_0338 ENOG4105CAY ferredoxin--nadp reductase FORC48_0342 ENOG4106UIA FORC48_0343 ENOG4106UIA FORC48_0346 ENOG4105BZU Histidine kinase FORC48_0350 ENOG410756H nucleotidyltransferase FORC48_0351 ENOG4105D2S major facilitator superfamily FORC48_0354 ENOG4105E5Q amino acid AbC transporter FORC48_0355 ENOG4105EAB amino acid AbC transporter FORC48_0357 ENOG4105C8Q Methyl-accepting chemotaxis FORC48_0360 ENOG4105DBV ornithine carbamoyltransferase FORC48_0362 ENOG4105C5B carbamate kinase FORC48_0363 ENOG4108W63 CRP FNR family transcriptional regulator FORC48_0365 ENOG4105DNP FAD linked oxidase domain protein FORC48_0367 ENOG4105CI1 PTS System FORC48_0370 ENOG4105C9U ATP-dependent DNA helicase RecQ FORC48_0373 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FORC48_0377 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FORC48_0378 ENOG4105D2X ABC transporter substrate-binding protein FORC48_0380 ENOG4105C5H ABC transporter FORC48_0386 ENOG41062JF Transcriptional regulator FORC48_0389 ENOG4105DEU major facilitator superfamily FORC48_0392 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FORC48_0395 ENOG4108N0M stress protein FORC48_0396 ENOG4106FN3 tellurium resistance protein FORC48_0397 ENOG4106FN3 tellurium resistance protein FORC48_0398 ENOG4107TS3 membrane protein, TerC FORC48_0399 ENOG4108TTB tellurium resistance protein FORC48_0402 ENOG41068PA UPF0435 protein FORC48_0403 ENOG4105KJF protein tyrosine phosphatase FORC48_0405 ENOG4107U9T Pfam:Ribonuclease_BN FORC48_0407 ENOG4105C59 p-type ATPase FORC48_0408 ENOG4108IPJ Membrane FORC48_0410 ENOG4105C3F Signal peptidase i FORC48_0412 ENOG4107ZTW SNARE associated Golgi FORC48_0415 ENOG410606W general stress protein FORC48_0416 ENOG4105UPD Calcium Proton FORC48_0423 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FORC48_0424 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FORC48_0426 ENOG4108JUB Transcriptional regulator FORC48_0428 ENOG4108IQI permease FORC48_0437 ENOG4108A04 Beta-lactamase FORC48_0440 ENOG4105CKK Glycosyl transferase, family 2 FORC48_0441 ENOG4107QQG Dehydrogenase FORC48_0442 ENOG4105C3I Nad-dependent epimerase dehydratase FORC48_0446 ENOG4105F1A Pyruvate formate-lyase FORC48_0450 ENOG4105CI2 imidazolone-5-propionate hydrolase FORC48_0451 ENOG4105ECP epimerase FORC48_0457 ENOG41067AE Membrane-bound metal-dependent hydrolase FORC48_0458 ENOG4105CEN a g-specific adenine glycosylase FORC48_0459 ENOG4106BXE FORC48_0465 ENOG4105BZ1 (ABC) transporter FORC48_0466 ENOG4107NBY Membrane FORC48_0468 ENOG4105CBC glutamate synthase FORC48_0470 ENOG4108IUW ABC transporter FORC48_0474 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC48_0475 ENOG4105G5W regulator Fur family FORC48_0479 ENOG4105CDY transcriptional regulatory protein FORC48_0481 ENOG4108JQC penicillin-binding protein 1A FORC48_0482 ENOG4108R9S DSBA oxidoreductase FORC48_0483 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FORC48_0485 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FORC48_0486 ENOG4105BZU Histidine kinase FORC48_0488 ENOG4105CYN Serine protein kinase FORC48_0492 ENOG4105C94 Transporter FORC48_0495 ENOG4105DZ6 Band 7 protein FORC48_0497 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FORC48_0498 ENOG4108V9W transcriptional regulatory protein FORC48_0499 ENOG4105D4T Citrate transporter FORC48_0504 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FORC48_0505 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC48_0506 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FORC48_0507 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FORC48_0508 ENOG4105BZ7 extracellular solute-binding protein family 1 FORC48_0510 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FORC48_0511 ENOG4108STX response regulator FORC48_0512 ENOG41062D9 Histidine kinase FORC48_0518 ENOG4108MRH transcriptional regulatory protein FORC48_0520 ENOG4105C6K Malic enzyme FORC48_0523 ENOG4108UZ3 Transporter FORC48_0524 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC48_0526 ENOG4105BZU Histidine kinase FORC48_0530 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FORC48_0531 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FORC48_0532 ENOG4108JB9 formate dehydrogenase FORC48_0536 ENOG4105CUB amino acid FORC48_0539 ENOG4105C59 p-type ATPase FORC48_0540 ENOG4105DAP Nicotinate phosphoribosyltransferase FORC48_0547 ENOG41073R8 VanW family FORC48_0548 ENOG4108KGH TRANSCRIPTIONal FORC48_0549 ENOG4105D9N nucleoside FORC48_0550 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FORC48_0551 ENOG4105C37 (CBS) domain FORC48_0552 ENOG4108IJ0 Aspartate ammonia-lyase FORC48_0553 ENOG4105DAA L-lactate FORC48_0556 ENOG4105DUX Transporter FORC48_0557 ENOG4108MES Periplasmic binding protein FORC48_0558 ENOG4105DQ5 transport system permease protein FORC48_0559 ENOG4108IHU transport system permease protein FORC48_0560 ENOG4105E0A ABC, transporter FORC48_0561 ENOG4105DMQ Methyltransferase FORC48_0562 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FORC48_0563 ENOG4105EXW epimerase dehydratase FORC48_0565 ENOG4107T89 von Willebrand factor, type A FORC48_0566 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FORC48_0567 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FORC48_0569 ENOG4105BZU Histidine kinase FORC48_0570 ENOG4105D5Q Arginine ornithine antiporter FORC48_0571 ENOG4107414 GntR family transcriptional regulator FORC48_0572 ENOG4105C5Y PTS System FORC48_0573 ENOG4105CG3 alpha amylase, catalytic region FORC48_0576 ENOG4105E1K spore germination protein FORC48_0577 ENOG4105CRN Aminoglycoside phosphotransferase FORC48_0580 ENOG4105CDA abc transporter atp-binding protein FORC48_0581 ENOG4105CT1 (ABC) transporter FORC48_0582 ENOG4105EAD ABC transporter FORC48_0583 ENOG4105DRP amino acid AbC transporter FORC48_0584 ENOG4108IQI permease FORC48_0589 ENOG4105D29 Helix-turn-helix type 11 domain protein FORC48_0590 ENOG4105NAE bifunctional deaminase-reductase domain protein FORC48_0591 ENOG4105BZU Histidine kinase FORC48_0596 ENOG4105CHH sulfate transporter FORC48_0597 ENOG41068KF Universal stress protein FORC48_0599 ENOG4105CXY transporter FORC48_0601 ENOG41067TZ transcriptional regulator, MarR family FORC48_0602 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC48_0603 ENOG4105ETE Transcriptional regulator (LacI family FORC48_0604 ENOG4108RVA ribokinase FORC48_0606 ENOG4105C2J ABC transporter FORC48_0607 ENOG4105CNN ABC, transporter FORC48_0608 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FORC48_0609 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FORC48_0615 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) FORC48_0621 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FORC48_0622 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FORC48_0623 ENOG41069ER domain protein FORC48_0624 ENOG4105VZ8 Transcriptional regulator FORC48_0625 ENOG4107D63 FORC48_0628 ENOG4105DUX Transporter FORC48_0633 ENOG4105C85 amino acid FORC48_0634 ENOG4105C7N Xanthine uracil vitamin C permease FORC48_0636 ENOG4105D7V transposase FORC48_0639 ENOG4105MA6 gCN5-related N-acetyltransferase FORC48_0643 ENOG4105CCU oxidase (Subunit III) FORC48_0644 ENOG4105BZ9 Cytochrome C oxidase, subunit I FORC48_0645 ENOG4105E2S oxidase) subunit II FORC48_0649 ENOG4106CAD Protein of unknown function (DUF3311) FORC48_0650 ENOG4105E1V na solute symporter FORC48_0653 ENOG4108NHD germination protein FORC48_0655 ENOG4105CE1 Ferrous iron transport protein b FORC48_0656 ENOG4105CE1 Ferrous iron transport protein b FORC48_0657 ENOG4105CE1 Ferrous iron transport protein b FORC48_0658 ENOG4105CVA phosphate FORC48_0659 ENOG4105C8U phosphate abc transporter FORC48_0660 ENOG4105E2Z phosphate ABC transporter (Permease FORC48_0663 ENOG41080XQ Signal transduction protein with cbs domains FORC48_0667 ENOG4105ETU transcriptional activator (TenA FORC48_0669 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FORC48_0671 ENOG4108VEU Thiamine monophosphate synthase FORC48_0672 ENOG41080HI glycine oxidase FORC48_0675 ENOG4105D06 uba thif-type nad fad binding protein FORC48_0676 ENOG4105DWF phosphomethylpyrimidine kinase FORC48_0687 ENOG4108INS Transcriptional regulator FORC48_0689 ENOG4105C7N Xanthine uracil vitamin C permease FORC48_0691 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FORC48_0695 ENOG4105C5Y PTS System FORC48_0698 ENOG4105K63 Thioredoxin FORC48_0702 ENOG4108B31 Spore germination protein FORC48_0706 ENOG4107Y03 Nitroreductase FORC48_0707 ENOG4105ED1 spovr family FORC48_0709 ENOG4108TCS Glutamyl endopeptidase FORC48_0714 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FORC48_0715 ENOG4105XTG Pfam:DUF156 FORC48_0716 ENOG4105VFE sira family FORC48_0717 ENOG4107TPS domain protein FORC48_0718 ENOG4105VFE sira family FORC48_0719 ENOG4105VFE sira family FORC48_0720 ENOG41085GJ domain protein FORC48_0721 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FORC48_0722 ENOG41087NI Sulfite exporter TauE/SafE FORC48_0724 ENOG4108KGH TRANSCRIPTIONal FORC48_0729 ENOG4105EMD TRANSCRIPTIONal FORC48_0730 ENOG4105VCP PTS System FORC48_0731 ENOG4105VZJ PTS System FORC48_0736 ENOG41069ER domain protein FORC48_0737 ENOG4107RBB ABC transporter, permease FORC48_0738 ENOG4105C19 ABC transporter FORC48_0744 ENOG4105WEF catalase FORC48_0751 ENOG4107T5V SNARE associated Golgi FORC48_0759 ENOG4105CUB amino acid FORC48_0760 ENOG4107RWR Sodium hydrogen exchanger FORC48_0762 ENOG4106KNT transcriptional regulator FORC48_0770 ENOG4108YXU transcriptional regulator AsnC family FORC48_0772 ENOG4108IXY short-chain dehydrogenase reductase FORC48_0775 ENOG4105KPY Small multidrug resistance protein FORC48_0782 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FORC48_0783 ENOG4105E5W Transporter FORC48_0785 ENOG4107RKG DJ-1/PfpI family FORC48_0786 ENOG4105CH6 catalase FORC48_0788 ENOG4105D5Q Arginine ornithine antiporter FORC48_0789 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FORC48_0791 ENOG4105C26 Dehydrogenase FORC48_0792 ENOG4105BZ1 (ABC) transporter FORC48_0793 ENOG4105BZ1 (ABC) transporter FORC48_0795 ENOG4105DRP amino acid AbC transporter FORC48_0796 ENOG4105CDA abc transporter atp-binding protein FORC48_0799 ENOG410839P FORC48_0807 ENOG4107FQX Alpha-acetolactate decarboxylase FORC48_0811 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FORC48_0812 ENOG4105D4P Coproporphyrinogen iii oxidase FORC48_0813 ENOG4105CEY Amp-dependent synthetase and ligase FORC48_0816 ENOG4105CHH sulfate transporter FORC48_0821 ENOG4105CGU Enoyl-CoA hydratase FORC48_0825 ENOG4105DER m42 family FORC48_0829 ENOG4105CTU Proline racemase FORC48_0830 ENOG4105CIF Ornithine Cyclodeaminase FORC48_0833 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC48_0834 ENOG4105C3U ABC transporter FORC48_0835 ENOG4108JQ7 (ABC) transporter FORC48_0844 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FORC48_0852 ENOG4108IBT Inherit from COG: transposase FORC48_0854 ENOG4105CSH Transporter FORC48_0856 ENOG4108MRH transcriptional regulatory protein FORC48_0866 ENOG4105FA0 parb-like partition protein FORC48_0868 ENOG4105CDU Replicative dna helicase FORC48_0873 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC48_0877 ENOG4105D9U N-acetyltransferase FORC48_0883 ENOG4105F6J Alpha beta hydrolase fold FORC48_0894 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FORC48_0897 ENOG4105CMT Dihydroxyacetone kinase FORC48_0899 ENOG4105CMT Dihydroxyacetone kinase FORC48_0906 ENOG41069ER domain protein FORC48_0913 ENOG4108WC5 Alpha Beta Hydrolase Fold protein FORC48_0924 ENOG4105WN5 stage II sporulation protein FORC48_0926 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC48_0928 ENOG4108MJI response regulator FORC48_0929 ENOG4105BZU Histidine kinase FORC48_0930 ENOG4105BZU Histidine kinase FORC48_0935 ENOG4105K8R UPF0145 protein FORC48_0939 ENOG4107QHE Choloylglycine hydrolase FORC48_0944 ENOG4107VRP DNA repair exonuclease FORC48_0945 ENOG4106D4I domain protein FORC48_0947 ENOG4105ED2 Beta-lactamase FORC48_0955 ENOG4108MUZ hydrolase FORC48_0960 ENOG4105F0F Oxalate decarboxylase FORC48_0961 ENOG41067QW Transcriptional regulator FORC48_0962 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FORC48_0965 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FORC48_0969 ENOG4105DU6 RNA polymerase FORC48_0974 ENOG4105EEM helicase FORC48_0976 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC48_0982 ENOG4105K59 histidine triad (HIT) protein FORC48_0989 ENOG410905X membrane-flanked domain protein FORC48_0990 ENOG4105CKV Membrane FORC48_1000 ENOG410905X membrane-flanked domain protein FORC48_1001 ENOG4105CKV Membrane FORC48_1002 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FORC48_1003 ENOG4105BZ4 penicillin-binding protein FORC48_1005 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FORC48_1006 ENOG4105C1Q protoporphyrinogen oxidase FORC48_1011 ENOG4105NA0 Transcriptional regulator FORC48_1014 ENOG4105ECB domain protein FORC48_1014 ENOG4105ECB domain protein FORC48_1017 ENOG4108MK9 spermidine N(1)-acetyltransferase FORC48_1019 ENOG4106AXD FORC48_1020 ENOG4108RQ5 Beta-lactamase domain-containing protein FORC48_1021 ENOG4105DF9 Lipoate-protein, ligase FORC48_1023 ENOG4105CEY Amp-dependent synthetase and ligase FORC48_1025 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FORC48_1026 ENOG4108I5D sulfate abc transporter FORC48_1027 ENOG4105ECW sulfate abc transporter FORC48_1028 ENOG4108IJ6 ABC transporter FORC48_1030 ENOG4105CNA YD repeat protein FORC48_1051 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) FORC48_1054 ENOG4105ENX hydrolase FORC48_1055 ENOG4107RN3 metallophosphoesterase FORC48_1056 ENOG4107TVP HD domain protein FORC48_1058 ENOG4108AEY RNA polymerase sigma factor FORC48_1059 ENOG41086D8 Transcriptional regulator FORC48_1063 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC48_1067 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FORC48_1068 ENOG4105C8Q Methyl-accepting chemotaxis FORC48_1069 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) FORC48_1072 ENOG4107QP3 malate synthase g FORC48_1076 ENOG4105VEQ Cold shock protein FORC48_1084 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FORC48_1094 ENOG4105ERH Fumarylacetoacetate hydrolase FORC48_1096 ENOG4105C8Y Acetylornithine aminotransferase FORC48_1097 ENOG4106BKT UPF0344 protein FORC48_1099 ENOG4105CAQ asparagine synthetase FORC48_1100 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FORC48_1101 ENOG4105CH6 catalase FORC48_1102 ENOG4105BZU Histidine kinase FORC48_1105 ENOG4108VPT UPF0234 protein FORC48_1106 ENOG4105QNR S1 RNA binding domain protein FORC48_1107 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC48_1109 ENOG4107AYK membrAne FORC48_1110 ENOG41073B9 FORC48_1112 ENOG4108KP7 hydrolase FORC48_1115 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FORC48_1120 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FORC48_1121 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FORC48_1125 ENOG4105C31 Tryptophanyl-tRNA synthetase FORC48_1128 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FORC48_1129 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC48_1131 ENOG4108JQ7 (ABC) transporter FORC48_1132 ENOG4105UQX Mate efflux family protein FORC48_1136 ENOG4108ZCF integral membrane protein FORC48_1138 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FORC48_1140 ENOG4105DPN Oligoendopeptidase f FORC48_1143 ENOG4108Z18 K06886 hemoglobin FORC48_1144 ENOG4105MIX Adenylate cyclase FORC48_1145 ENOG4106EFP UPF0738 protein FORC48_1147 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FORC48_1148 ENOG4105EMS pseudouridine synthase FORC48_1152 ENOG4105K64 Glycosyl transferase, family 2 FORC48_1156 ENOG4107TVC Glycosyl transferase, family 2 FORC48_1160 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FORC48_1161 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FORC48_1163 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FORC48_1173 ENOG4108ZMI UPF0477 protein FORC48_1178 ENOG4105CK7 Sodium proline symporter FORC48_1180 ENOG4105CRQ synthase (Component I) FORC48_1181 ENOG4105DDQ anthranilate synthase FORC48_1185 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FORC48_1200 ENOG4105C7S Dehydrogenase FORC48_1201 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FORC48_1203 ENOG4105VZ8 Transcriptional regulator FORC48_1214 ENOG4105DZ1 carboxypeptidase FORC48_1215 ENOG4105VFR signal peptidase FORC48_1222 ENOG4105C26 Dehydrogenase FORC48_1223 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC48_1224 ENOG4105F38 ABC transporter, permease FORC48_1225 ENOG4105D38 putrescine abc transporter FORC48_1226 ENOG4107RUE extracellular solute-binding protein family 1 FORC48_1228 ENOG4105EYF MMPL domain protein FORC48_1230 ENOG4108YBP pseudouridine synthase FORC48_1232 ENOG4105K4I Scp-like extracellular FORC48_1233 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FORC48_1234 ENOG4105CQB FAD linked oxidase domain protein FORC48_1237 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC48_1238 ENOG4105BZU Histidine kinase FORC48_1239 ENOG4105JXH GntR family transcriptional regulator FORC48_1243 ENOG4106A3R peptidase FORC48_1245 ENOG4108QTI )-transporter FORC48_1247 ENOG4107TS3 membrane protein, TerC FORC48_1248 ENOG4105CZN Potassium uptake protein FORC48_1249 ENOG410681C small acid-soluble spore protein FORC48_1250 ENOG4108Z7G MaoC domain protein dehydratase FORC48_1254 ENOG4105CHR reductase FORC48_1260 ENOG4105C4Y ABC transporter FORC48_1261 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC48_1262 ENOG4107RCV ABC transporter, permease FORC48_1266 ENOG4105E98 transcriptional regulator DeoR family FORC48_1269 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FORC48_1271 ENOG4105PXI polysaccharide deacetylase FORC48_1273 ENOG4105BZU Histidine kinase FORC48_1274 ENOG41090MY MarR family Transcriptional regulator FORC48_1276 ENOG4106DF1 FORC48_1279 ENOG4105BZU Histidine kinase FORC48_1280 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FORC48_1281 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FORC48_1282 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FORC48_1290 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FORC48_1291 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FORC48_1292 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FORC48_1293 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FORC48_1294 ENOG4105CZV ABC transporter FORC48_1296 ENOG4105CJ1 ABC, transporter FORC48_1304 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FORC48_1306 ENOG4105EA8 2-Nitropropane dioxygenase FORC48_1307 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FORC48_1309 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FORC48_1314 ENOG4105NQC Flavodoxin FORC48_1322 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FORC48_1328 ENOG4105CZN Potassium uptake protein FORC48_1329 ENOG41063Y9 FORC48_1330 ENOG4105KBJ sporulation protein ytfj FORC48_1335 ENOG4105CM2 brancheD-chain amino acid aminotransferase FORC48_1336 ENOG4105C7K acetolactate synthase FORC48_1337 ENOG4108ZP8 Acetolactate synthase small subunit FORC48_1338 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FORC48_1341 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FORC48_1345 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FORC48_1346 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FORC48_1351 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase FORC48_1352 ENOG4107RVV histidinol phosphate phosphatase, hisj family FORC48_1355 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FORC48_1356 ENOG4105E0M Sulfatase FORC48_1358 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FORC48_1361 ENOG4107S4M Sulfate adenylate transferase FORC48_1362 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FORC48_1363 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FORC48_1365 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FORC48_1366 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FORC48_1367 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FORC48_1368 ENOG4105C8J )-transporter FORC48_1373 ENOG4105DFD Na H antiporter FORC48_1377 ENOG4105ENE Histidine kinase FORC48_1378 ENOG4105WH1 Two component transcriptional regulator luxr family FORC48_1382 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FORC48_1388 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FORC48_1392 ENOG4105CJ3 phosphate transporter FORC48_1393 ENOG4107GRR phosphate transport regulator FORC48_1394 ENOG4105BZ4 penicillin-binding protein FORC48_1397 ENOG4105BZU Histidine kinase FORC48_1398 ENOG4105I3N Conserved Protein FORC48_1402 ENOG4105BZU Histidine kinase FORC48_1408 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FORC48_1409 ENOG4105DZ1 carboxypeptidase FORC48_1410 ENOG4108JIC nucleoside recognition domain protein FORC48_1412 ENOG4105FE9 pseudouridine synthase FORC48_1413 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC48_1414 ENOG4107TWT Cytochrome c biogenesis protein FORC48_1415 ENOG4105CRE cytochrome C FORC48_1416 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC48_1417 ENOG4105BZU Histidine kinase FORC48_1418 ENOG4108WBT adenosyltransferase FORC48_1421 ENOG4108SAX Membrane FORC48_1424 ENOG4105C9U ATP-dependent DNA helicase RecQ FORC48_1425 ENOG4105I7S Abortive infection protein FORC48_1427 ENOG4107RGJ metallophosphoesterase FORC48_1428 ENOG4108XDN Transcriptional regulator FORC48_1429 ENOG4108S6Z Negative regulator of genetic competence FORC48_1434 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FORC48_1435 ENOG4107RB3 L-asparaginase FORC48_1439 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FORC48_1442 ENOG4105S2F FORC48_1443 ENOG41065D1 FORC48_1450 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FORC48_1453 ENOG4105XXQ heptaprenyl diphosphate synthase component I FORC48_1455 ENOG4105EAH synthase FORC48_1456 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FORC48_1457 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FORC48_1460 ENOG41068YB TPR repeat-containing protein FORC48_1463 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FORC48_1464 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FORC48_1471 ENOG4108JYZ YitT family FORC48_1472 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FORC48_1473 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FORC48_1475 ENOG4105FJR Lmbe family FORC48_1476 ENOG4105CPK Glycosyl transferase (Group 1 FORC48_1480 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FORC48_1483 ENOG4105DVT helicase FORC48_1484 ENOG4105YAC FORC48_1488 ENOG4105CSM endonuclease III FORC48_1490 ENOG4105BZ4 penicillin-binding protein FORC48_1501 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FORC48_1510 ENOG4105DVT helicase FORC48_1511 ENOG4105CTD carboxy-peptidase FORC48_1513 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FORC48_1514 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) FORC48_1515 ENOG4105C2W permease FORC48_1516 ENOG4105DHF Membrane FORC48_1518 ENOG410890F Dynamin family FORC48_1520 ENOG4108W0I acetyltransferase FORC48_1522 ENOG4105KHC sulfurtransferase FORC48_1525 ENOG4106032 Glutathionylspermidine synthase FORC48_1531 ENOG4105HTX biosynthesis protein FORC48_1537 ENOG4105CPK Glycosyl transferase (Group 1 FORC48_1540 ENOG4108SZE gCN5-related N-acetyltransferase FORC48_1544 ENOG41081VK Ribonuclease FORC48_1557 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FORC48_1559 ENOG4107RWR Sodium hydrogen exchanger FORC48_1560 ENOG4105CN5 Metallo-Beta-Lactamase FORC48_1561 ENOG4108Z5V transcriptional regulator, merr family FORC48_1563 ENOG4105H67 Protein of unknown function (DUF421) FORC48_1564 ENOG41080C8 DUF218 domain FORC48_1571 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FORC48_1573 ENOG4107R0U MotA TolQ exbB proton channel FORC48_1574 ENOG4105ER2 Ompa motb domain protein FORC48_1575 ENOG4107YTP response regulator receiver protein FORC48_1576 ENOG4105CBS Chea signal transduction histidine kinase FORC48_1577 ENOG4105DD5 Flagellar motor switch protein FORC48_1580 ENOG4105BZU Histidine kinase FORC48_1584 ENOG4105E1Q flagellar hook-associated protein FORC48_1585 ENOG4105DTJ flagellar hook-associated protein FORC48_1589 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FORC48_1590 ENOG4108ZC9 flagellar basal-body rod protein flgc FORC48_1591 ENOG41075Z6 flagellar hook-basal body complex protein fliE FORC48_1592 ENOG4107U2N Flagellar M-ring protein FORC48_1593 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FORC48_1599 ENOG4105BZE flagellar hook protein, FlgE FORC48_1602 ENOG4107R88 Chemotaxis protein (CheV) FORC48_1604 ENOG4105I03 Flagellin FORC48_1605 ENOG4105I03 Flagellin FORC48_1606 ENOG4105E4C Lytic transglycosylase catalytic FORC48_1608 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FORC48_1609 ENOG4105DD5 Flagellar motor switch protein FORC48_1611 ENOG4105CN7 Flagellar biosynthetic protein FliP FORC48_1612 ENOG4105VS8 Flagellar biosynthetic protein fliq FORC48_1614 ENOG4105D00 flagellar biosynthetic protein flhB FORC48_1615 ENOG4105D7B Flagellar biosynthesis protein flha FORC48_1616 ENOG4105FZW flagellar biosynthesis regulator FlhF FORC48_1617 ENOG4105KTQ flagellar basal-body rod protein FORC48_1618 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FORC48_1624 ENOG4105KAC Antibiotic biosynthesis monooxygenase FORC48_1629 ENOG4105DUM transcriptional regulator, lysR family FORC48_1632 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FORC48_1633 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FORC48_1639 ENOG4105CVJ phosphoglycerate mutase FORC48_1641 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FORC48_1645 ENOG4105CAQ asparagine synthetase FORC48_1649 ENOG4105PGM cation diffusion facilitator family transporter FORC48_1651 ENOG4105DRR Transcriptional regulator, GntR family FORC48_1652 ENOG4108UZ3 Transporter FORC48_1654 ENOG4105CKI cobalamin synthesis protein FORC48_1655 ENOG4108PJD permease FORC48_1658 ENOG4105DFD Na H antiporter FORC48_1659 ENOG4105VUF Transcriptional regulator FORC48_1661 ENOG4105C9Q fumarate hydratase class II FORC48_1665 ENOG4107QJQ Mate efflux family protein FORC48_1666 ENOG4105EC3 peptidase S51, dipeptidase E FORC48_1670 ENOG4107QIV Cytochrome c biogenesis protein FORC48_1671 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC48_1675 ENOG4106BRA Membrane FORC48_1682 ENOG4105CJ1 ABC, transporter FORC48_1687 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FORC48_1690 ENOG4108IJ0 Aspartate ammonia-lyase FORC48_1691 ENOG4105C6K Malic enzyme FORC48_1699 ENOG41067QW Transcriptional regulator FORC48_1705 ENOG4105FVX FORC48_1706 ENOG4105E09 nadh pyrophosphatase FORC48_1709 ENOG4105CSR polyphosphate kinase 2 FORC48_1712 ENOG4105DXI Major Facilitator superfamily FORC48_1715 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FORC48_1716 ENOG4105EU0 Major facilitator Superfamily FORC48_1717 ENOG4105C6T cysteine synthase FORC48_1721 ENOG4105C8J )-transporter FORC48_1724 ENOG4105X5K response regulator receiver protein FORC48_1725 ENOG4105H67 Protein of unknown function (DUF421) FORC48_1731 ENOG4105CHR reductase FORC48_1732 ENOG4105CM2 brancheD-chain amino acid aminotransferase FORC48_1733 ENOG4105C7K acetolactate synthase FORC48_1735 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FORC48_1736 ENOG4105C01 Dihydroxy-acid dehydratase FORC48_1737 ENOG4105C7B Threonine dehydratase FORC48_1741 ENOG4105C6X Major Facilitator FORC48_1742 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FORC48_1744 ENOG4105DY9 regulatoR FORC48_1745 ENOG4105CYC Transferase FORC48_1746 ENOG4105K5X acetyltransferase FORC48_1750 ENOG41068WN FORC48_1754 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FORC48_1755 ENOG4105C72 UPF0176 protein FORC48_1757 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FORC48_1759 ENOG4105C0X amino acid FORC48_1769 ENOG410849A acetyltransferase, (GNAT) family FORC48_1773 ENOG4107RHR regulatoR FORC48_1775 ENOG4105D9N nucleoside FORC48_1776 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FORC48_1782 ENOG410811B TRANSCRIPTIONal FORC48_1785 ENOG4107RAQ aminopeptidase FORC48_1787 ENOG4107R16 Multicopper oxidase FORC48_1790 ENOG4105MKU Transcriptional regulator FORC48_1799 ENOG4105W8Z 4'-phosphopantetheinyl transferase FORC48_1807 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FORC48_1817 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FORC48_1818 ENOG4108KP7 hydrolase FORC48_1819 ENOG4105C8V SAICAR synthetase FORC48_1821 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FORC48_1822 ENOG4105CHR reductase FORC48_1824 ENOG4105D9U N-acetyltransferase FORC48_1827 ENOG4108T5E Copper resistance protein FORC48_1828 ENOG4105KTB nuclear export factor GLE1 FORC48_1829 ENOG4107RT3 EamA-like transporter family FORC48_1830 ENOG4105GZI Transcriptional regulator FORC48_1831 ENOG4108Z40 Transcriptional regulator FORC48_1832 ENOG4107ZXU DSBA oxidoreductase FORC48_1833 ENOG4108TVJ Nitroreductase FORC48_1835 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FORC48_1836 ENOG4106F5Q Membrane FORC48_1837 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FORC48_1840 ENOG4105CKI cobalamin synthesis protein FORC48_1842 ENOG4105C0Z ABC transporter FORC48_1843 ENOG4108IV0 ABC, transporter FORC48_1844 ENOG4105C32 Amino acid ABC transporter (Permease) FORC48_1846 ENOG4105SKE transcriptional Regulator LysR family FORC48_1853 ENOG4105C4M (Ubiquinol oxidase) subunit I FORC48_1854 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FORC48_1855 ENOG4108JJ9 ABC, transporter FORC48_1856 ENOG4108JJ8 (ABC) transporter FORC48_1858 ENOG4105K64 Glycosyl transferase, family 2 FORC48_1860 ENOG4108UT6 Transferase hexapeptide repeat containing protein FORC48_1871 ENOG4105BZ1 (ABC) transporter FORC48_1872 ENOG4105EFI regulatoR FORC48_1873 ENOG4105BZU Histidine kinase FORC48_1875 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FORC48_1876 ENOG4108ZJ4 polysaccharide deacetylase FORC48_1880 ENOG4105D6E homoserine dehydrogenase FORC48_1885 ENOG4108KGH TRANSCRIPTIONal FORC48_1887 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC48_1888 ENOG4105BZU Histidine kinase FORC48_1889 ENOG4107VMI polysaccharide deacetylase FORC48_1891 ENOG4105KT7 mgtC SapB transporter FORC48_1892 ENOG4105VRR gCN5-related N-acetyltransferase FORC48_1894 ENOG4105DUU IucA IucC family protein FORC48_1895 ENOG4105CEY Amp-dependent synthetase and ligase FORC48_1898 ENOG4108WBH protein TIM barrel FORC48_1899 ENOG4105YWU small acid-soluble spore protein FORC48_1901 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FORC48_1902 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC48_1912 ENOG4105KRN Transcriptional regulator, abrb family FORC48_1914 ENOG4105YVS arsR family transcriptional regulator FORC48_1916 ENOG4107SET aldo keto reductase FORC48_1917 ENOG4107XZQ multidrug resistance protein FORC48_1919 ENOG4105KAF membrAne FORC48_1924 ENOG4105C8Q Methyl-accepting chemotaxis FORC48_1927 ENOG4108K88 Membrane FORC48_1928 ENOG4108WPJ Ferritin-like domain FORC48_1931 ENOG4105DEN Luciferase family FORC48_1934 ENOG4105VMI -acetyltransferase FORC48_1935 ENOG4107QM2 Aldo Keto reductase FORC48_1936 ENOG4105CKI cobalamin synthesis protein FORC48_1938 ENOG4105DSE periplasmic solute binding protein FORC48_1940 ENOG4105K4T epimerase FORC48_1942 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FORC48_1951 ENOG4107T5V SNARE associated Golgi FORC48_1954 ENOG4108PJD permease FORC48_1956 ENOG4108S4H thioesterase Superfamily protein FORC48_1959 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FORC48_1963 ENOG4105SXS Protein of unknown function (DUF456) FORC48_1964 ENOG4105C37 (CBS) domain FORC48_1968 ENOG4108Z7R Chaperone CsaA FORC48_1972 ENOG4108ZRV stage ii sporulation protein p FORC48_1974 ENOG4108VXD carboxy-peptidase FORC48_1976 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FORC48_1980 ENOG4108ZRV stage ii sporulation protein p FORC48_1982 ENOG4108X4Q Hydrolase FORC48_1985 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FORC48_1988 ENOG41087PP glycosyltransferase MGT family FORC48_1989 ENOG4108JYZ YitT family FORC48_1990 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC48_1996 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FORC48_2000 ENOG4106PAW secretion accessory protein EsaA YueB FORC48_2002 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) FORC48_2003 ENOG4108MGT Required for secretion of EsxA and EsxB FORC48_2019 ENOG4105KBJ sporulation protein ytfj FORC48_2024 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FORC48_2029 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FORC48_2031 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FORC48_2032 ENOG4105EMN RNA polymerase sigma factor FORC48_2037 ENOG4108V06 Glutathione peroxidase FORC48_2040 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FORC48_2042 ENOG4108IUE nitrate reductase beta subunit FORC48_2043 ENOG4105R3A Nitrate reductase FORC48_2045 ENOG4107V6Q Cyclic nucleotide-binding domain FORC48_2046 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FORC48_2047 ENOG4105D06 uba thif-type nad fad binding protein FORC48_2048 ENOG4105CVM Molybdenum cofactor synthesis domain protein FORC48_2049 ENOG4108ZAF Molybdopterin FORC48_2054 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FORC48_2055 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FORC48_2056 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FORC48_2057 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FORC48_2058 ENOG4108IFG nitrite reductase, (NAD(P)H) FORC48_2059 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FORC48_2066 ENOG4105MCT stage V sporulation protein S FORC48_2071 ENOG4105DQ6 Transposase FORC48_2081 ENOG4105C5H ABC transporter FORC48_2084 ENOG4108UUM single-stranded DNA-binding protein FORC48_2091 ENOG4107YX5 Pfam:DUF548 FORC48_2092 ENOG4105C75 arginyL-tRNA synthetase FORC48_2096 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FORC48_2101 ENOG4105C5S asparaginyl-tRNA synthetase FORC48_2102 ENOG4105C8J )-transporter FORC48_2106 ENOG4107XGZ Hydrolase FORC48_2107 ENOG4105CY2 Citrate transporter FORC48_2111 ENOG4105KD7 acetyltransferase FORC48_2113 ENOG4105VMP Transcriptional regulator FORC48_2114 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FORC48_2119 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FORC48_2122 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FORC48_2123 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FORC48_2125 ENOG4107RVG penicillin-binding protein FORC48_2126 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FORC48_2127 ENOG4105E9Q Acyl-transferase FORC48_2128 ENOG4108UT2 hemolysin iii FORC48_2130 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FORC48_2132 ENOG4108RCR degv family FORC48_2135 ENOG4108KF3 Electron transport protein SCO1 SenC FORC48_2136 ENOG4107Y70 Heat shock protein FORC48_2137 ENOG4105CAQ asparagine synthetase FORC48_2140 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FORC48_2141 ENOG4108MES Periplasmic binding protein FORC48_2142 ENOG4105F0I Aminotransferase FORC48_2148 ENOG4105D8X mechanosensitive ion channel FORC48_2149 ENOG4105BZU Histidine kinase FORC48_2150 ENOG4105WH1 Two component transcriptional regulator luxr family FORC48_2151 ENOG4106KNT transcriptional regulator FORC48_2152 ENOG4107ZY0 Phenazine biosynthesis-like protein FORC48_2155 ENOG4105DQ6 Transposase FORC48_2158 ENOG4105CMG Carbohydrate kinase FORC48_2159 ENOG4105C6Z Gluconate FORC48_2161 ENOG4108YV3 Protein of unknown function (DUF2711) FORC48_2167 ENOG4108IJ8 ABC transporter FORC48_2168 ENOG4105E90 ABC transporter FORC48_2175 ENOG4105C37 (CBS) domain FORC48_2180 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FORC48_2183 ENOG4107S4Y M20 DapE family protein YgeY FORC48_2184 ENOG4108TSC N-acetyltransferase FORC48_2185 ENOG4108JUB Transcriptional regulator FORC48_2186 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FORC48_2195 ENOG410841Q phosphoesterase PA-phosphatase related protein FORC48_2198 ENOG4105SZ6 Thioredoxin FORC48_2199 ENOG4105KNA -acetyltransferase FORC48_2205 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC48_2216 ENOG4105BZ4 penicillin-binding protein FORC48_2218 ENOG4105CZM Major Facilitator FORC48_2219 ENOG4105W8X HesB YadR YfhF-family protein FORC48_2221 ENOG4105DXD 2-methylcitrate dehydratase FORC48_2222 ENOG4105CR4 methylisocitrate lyase FORC48_2223 ENOG4105C1G acyl-Coa dehydrogenase FORC48_2224 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FORC48_2226 ENOG4105N14 lysine exporter protein LysE YggA FORC48_2227 ENOG4105E39 Enoyl-CoA hydratase FORC48_2230 ENOG4107RFY SbcCD D subunit FORC48_2231 ENOG4105EYH Exonuclease FORC48_2238 ENOG4105FCD Major Facilitator FORC48_2239 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FORC48_2240 ENOG4105E4F Isochorismate synthase FORC48_2241 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FORC48_2242 ENOG4105WQI isochorismatase FORC48_2243 ENOG4105CEY Amp-dependent synthetase and ligase FORC48_2244 ENOG4105WQT MbtH domain protein FORC48_2245 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC48_2248 ENOG4105K70 DNA-binding protein FORC48_2252 ENOG4105BZG amino acid carrier protein FORC48_2258 ENOG4105FE9 pseudouridine synthase FORC48_2259 ENOG4105C22 threonyL-tRNA synthetase FORC48_2260 ENOG4105C19 ABC transporter FORC48_2271 ENOG41081I9 integral membrane protein FORC48_2273 ENOG4108Y4K DNA-binding transcriptional activator FORC48_2275 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) FORC48_2277 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FORC48_2279 ENOG4105EYF MMPL domain protein FORC48_2283 ENOG4105WCN acetyltransferase FORC48_2288 ENOG4105C1Q protoporphyrinogen oxidase FORC48_2290 ENOG41068WN FORC48_2296 ENOG4107V2S Transcriptional regulator FORC48_2297 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FORC48_2301 ENOG4105DND Transcriptional regulator FORC48_2302 ENOG4108RPX mosc domain containing protein FORC48_2305 ENOG4105BZ1 (ABC) transporter FORC48_2306 ENOG4105BZ1 (ABC) transporter FORC48_2313 ENOG4108JCI Transcriptional regulator FORC48_2319 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) FORC48_2320 ENOG4108KPJ rna polymerase sigma factor FORC48_2325 ENOG4105F32 YngK protein FORC48_2329 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) FORC48_2330 ENOG4105RD7 BadF BadG BcrA BcrD FORC48_2331 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FORC48_2333 ENOG4105C7B Threonine dehydratase FORC48_2334 ENOG4108INS Transcriptional regulator FORC48_2338 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FORC48_2340 ENOG4105C1J atp-dependent rna helicase FORC48_2345 ENOG4108IG5 Transcriptional regulator FORC48_2349 ENOG41088CC tellurite resistance protein tehB FORC48_2351 ENOG4108I0C methyltransferase FORC48_2352 ENOG4107RA9 decarboxylase FORC48_2353 ENOG41090HR transcriptional regulator FORC48_2359 ENOG4105CIN aminoacyl-histidine dipeptidase FORC48_2365 ENOG4105KRN Transcriptional regulator, abrb family FORC48_2367 ENOG4105EJ9 Membrane FORC48_2368 ENOG4105EQK -acetyltransferase FORC48_2375 ENOG4105W8Z 4'-phosphopantetheinyl transferase FORC48_2377 ENOG4105CHR reductase FORC48_2394 ENOG4108IG5 Transcriptional regulator FORC48_2396 ENOG4105FQP Beta-lactamase FORC48_2397 ENOG4107RVG penicillin-binding protein FORC48_2400 ENOG4107RF6 penicillin-binding protein FORC48_2401 ENOG4107RF6 penicillin-binding protein FORC48_2403 ENOG4105DIN metallophosphoesterase FORC48_2405 ENOG4105CJ1 ABC, transporter FORC48_2407 ENOG4107Z3H Transcriptional regulator, TetR family FORC48_2410 ENOG4105C1G acyl-Coa dehydrogenase FORC48_2411 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FORC48_2412 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FORC48_2413 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FORC48_2414 ENOG4105E39 Enoyl-CoA hydratase FORC48_2415 ENOG4107QX3 carboxylase FORC48_2416 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FORC48_2422 ENOG4105DBI uridine monophosphokinase FORC48_2426 ENOG4105DZ1 carboxypeptidase FORC48_2429 ENOG4105T9C HD domain FORC48_2431 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FORC48_2435 ENOG41075H3 AraC family transcriptional regulator FORC48_2441 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FORC48_2443 ENOG4105CHR reductase FORC48_2444 ENOG4105KVH Transcriptional regulator FORC48_2448 ENOG4105MDS 4-oxalocrotonate tautomerase FORC48_2449 ENOG4107V2S Transcriptional regulator FORC48_2455 ENOG4105EFA 4-hydroxyphenylacetate FORC48_2458 ENOG4105CPQ Dehydrogenase FORC48_2460 ENOG410900G Protein of unknown function (DUF421) FORC48_2463 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FORC48_2475 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FORC48_2482 ENOG4105D6E homoserine dehydrogenase FORC48_2484 ENOG4105CPF Cell wall formation (By similarity) FORC48_2485 ENOG4105ETU transcriptional activator (TenA FORC48_2490 ENOG4105VTR Integrase FORC48_2545 ENOG4105XSJ toxin secretion phage lysis holin FORC48_2563 ENOG410667J hydrolase FORC48_2564 ENOG4105BZU Histidine kinase FORC48_2565 ENOG4107RF6 penicillin-binding protein FORC48_2570 ENOG4108JJB ABC transporter FORC48_2573 ENOG4108HGU Histidine kinase FORC48_2584 ENOG4105CB2 alcohol dehydrogenase FORC48_2585 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FORC48_2586 ENOG4105CJN penicillin-binding protein FORC48_2598 ENOG4107Y80 Major Facilitator superfamily FORC48_2599 ENOG4108Z5V transcriptional regulator, merr family FORC48_2604 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FORC48_2609 ENOG4107Y9U Membrane FORC48_2618 ENOG4105FCD Major Facilitator FORC48_2620 ENOG4105E09 nadh pyrophosphatase FORC48_2621 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FORC48_2625 ENOG4108XI2 Domain of unknown function (DUF1963) FORC48_2630 ENOG4108NRW Phospholipase, patatin family FORC48_2631 ENOG4105KWG Pfam:DUF1696 FORC48_2633 ENOG4108YYS metal-dependent hydrolase (By similarity) FORC48_2636 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FORC48_2638 ENOG4105PKS Excinuclease abc c subunit domain protein FORC48_2646 ENOG4107VFR oxidoreductase FORC48_2653 ENOG4105U0R haloacid dehalogenase-like hydrolase FORC48_2654 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC48_2655 ENOG4105BZU Histidine kinase FORC48_2659 ENOG4107WD8 ABC transporter, permease FORC48_2662 ENOG4105DY8 decarboxylase FORC48_2665 ENOG4108IUM Glycogen debranching enzyme FORC48_2667 ENOG4105CGH 5'-nucleotidase FORC48_2672 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FORC48_2673 ENOG4105FDR Membrane FORC48_2674 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC48_2675 ENOG4105CIS alcohol dehydrogenase FORC48_2676 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FORC48_2685 ENOG4105MSI germination protein ypeb FORC48_2691 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) FORC48_2692 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FORC48_2693 ENOG4107Z3H Transcriptional regulator, TetR family FORC48_2698 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FORC48_2702 ENOG4105E98 transcriptional regulator DeoR family FORC48_2705 ENOG41062ES Transcriptional regulator FORC48_2709 ENOG4107QKR Dehydrogenase FORC48_2711 ENOG4107RUY (E1 component), alpha subunit FORC48_2714 ENOG4105E1F short-chain dehydrogenase reductase FORC48_2715 ENOG4105RHY Pfam:UPF0157 FORC48_2722 ENOG4107SQ8 Glycine betaine FORC48_2723 ENOG4108IJ7 Glycine betaine FORC48_2728 ENOG4105E66 phosphoriboisomerase A FORC48_2729 ENOG41082BV acetyltransferase FORC48_2730 ENOG4108M1A Chitin-binding protein FORC48_2735 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FORC48_2736 ENOG4105MSB protein, conserved in bacteria FORC48_2741 ENOG4108Z7F N-acetyltransferase FORC48_2747 ENOG4105EEM helicase FORC48_2750 ENOG4105C9U ATP-dependent DNA helicase RecQ FORC48_2761 ENOG4108M1A Chitin-binding protein FORC48_2764 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FORC48_2766 ENOG4105BZG amino acid carrier protein FORC48_2767 ENOG4105C26 Dehydrogenase FORC48_2768 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FORC48_2769 ENOG4105CTU Proline racemase FORC48_2770 ENOG4105CTU Proline racemase FORC48_2771 ENOG41080HI glycine oxidase FORC48_2773 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FORC48_2780 ENOG4105DCI Phosphohydrolase FORC48_2781 ENOG4107T5V SNARE associated Golgi FORC48_2783 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FORC48_2787 ENOG4105DTQ mandelate racemase muconate lactonizing FORC48_2790 ENOG4107SET aldo keto reductase FORC48_2797 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FORC48_2798 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC48_2799 ENOG4105BZU Histidine kinase FORC48_2800 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC48_2804 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 FORC48_2807 ENOG4105DPN Oligoendopeptidase f FORC48_2808 ENOG4105EPR degv family FORC48_2821 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FORC48_2822 ENOG4106K7D Major facilitator family transporter FORC48_2826 ENOG4107BMA Transglycosylase associated protein FORC48_2829 ENOG41089UC methyltransferase, type 11 FORC48_2838 ENOG4105CHM Aminotransferase FORC48_2841 ENOG4108ZMI UPF0477 protein FORC48_2850 ENOG4105C02 permease FORC48_2853 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FORC48_2854 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FORC48_2855 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FORC48_2856 ENOG4105D7T ABC transporter FORC48_2863 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FORC48_2871 ENOG4107VC0 DNA alkylation repair enzyme FORC48_2873 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FORC48_2874 ENOG4107VMI polysaccharide deacetylase FORC48_2876 ENOG4108ZCF integral membrane protein FORC48_2877 ENOG4105E0M Sulfatase FORC48_2878 ENOG4105C5H ABC transporter FORC48_2880 ENOG4105EYF MMPL domain protein FORC48_2881 ENOG41082JN Transcriptional regulator FORC48_2885 ENOG4105CIH Imidazole acetol-phosphate transaminase FORC48_2886 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FORC48_2887 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FORC48_2895 ENOG41069ER domain protein FORC48_2897 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FORC48_2898 ENOG4105DNP FAD linked oxidase domain protein FORC48_2904 ENOG4105F5R ABC transporter FORC48_2905 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FORC48_2906 ENOG4105C2J ABC transporter FORC48_2908 ENOG4105DKT Transcriptional regulator FORC48_2909 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) FORC48_2911 ENOG41061GT Aldolase FORC48_2914 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FORC48_2921 ENOG4105II7 pyrroline-5-carboxylate reductase FORC48_2923 ENOG4107258 Transcriptional regulator FORC48_2926 ENOG4105ECK Fatty Acid Desaturase FORC48_2928 ENOG4107RBI VanW family FORC48_2929 ENOG4105G6Z alkaline phosphatase FORC48_2931 ENOG4105VMP Transcriptional regulator FORC48_2935 ENOG41068WN FORC48_2941 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FORC48_2946 ENOG4105CKK Glycosyl transferase, family 2 FORC48_2952 ENOG4105C8Y Acetylornithine aminotransferase FORC48_2961 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FORC48_2965 ENOG4108IBT Inherit from COG: transposase FORC48_2969 ENOG4105DQ6 Transposase FORC48_2971 ENOG4108TVJ Nitroreductase FORC48_2972 ENOG4105FS7 Transcriptional regulator FORC48_2975 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FORC48_2976 ENOG4105WEC Molybdate metabolism regulator FORC48_2980 ENOG4108DMH HTH_ARAC FORC48_2981 ENOG4108XET gCN5-related N-acetyltransferase FORC48_2984 ENOG4108PCN EamA-like transporter family FORC48_2988 ENOG4107XJU UPF0178 protein FORC48_2995 ENOG410635A Membrane FORC48_2997 ENOG4108IQI permease FORC48_2999 ENOG4105F1N DNA alkylation repair FORC48_3007 ENOG4107RF6 penicillin-binding protein FORC48_3008 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FORC48_3012 ENOG4105E7W lamb ycsf family protein FORC48_3014 ENOG4105P4J Allophanate hydrolase, subunit 1 FORC48_3015 ENOG4107258 Transcriptional regulator FORC48_3017 ENOG4106N3A copper homeostasis protein cutc FORC48_3018 ENOG4108ZHR arsR family transcriptional regulator FORC48_3020 ENOG4105FDT acyl-CoA dehydrogenase FORC48_3024 ENOG4105DWD nucleoside recognition domain protein FORC48_3034 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FORC48_3040 ENOG4105E2A Dehydrogenase FORC48_3041 ENOG4108IJ0 Aspartate ammonia-lyase FORC48_3042 ENOG4105HDK L-asparaginase FORC48_3043 ENOG4108IMY Transcriptional regulator FORC48_3046 ENOG4108B31 Spore germination protein FORC48_3048 ENOG4105BZU Histidine kinase FORC48_3053 ENOG41075H3 AraC family transcriptional regulator FORC48_3055 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FORC48_3056 ENOG4105CUB amino acid FORC48_3057 ENOG4105II7 pyrroline-5-carboxylate reductase FORC48_3059 ENOG4105C6K Malic enzyme FORC48_3061 ENOG4108NHD germination protein FORC48_3062 ENOG4108Q8B Spore germination protein FORC48_3074 ENOG4105CGH 5'-nucleotidase FORC48_3076 ENOG4105CHJ isochorismatase hydrolase FORC48_3081 ENOG41090MY MarR family Transcriptional regulator FORC48_3086 ENOG4105F6J Alpha beta hydrolase fold FORC48_3089 ENOG4108606 TspO/MBR family FORC48_3090 ENOG4105CVP deoxyribo-dipyrimidine photolyase FORC48_3094 ENOG4105F2M alpha beta hydrolase fold-3 domain protein FORC48_3097 ENOG4108TWJ NADH dehydrogenase subunit 5 FORC48_3098 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FORC48_3099 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC48_3101 ENOG4105F27 Major Facilitator FORC48_3102 ENOG4106P55 Transcriptional regulator FORC48_3106 ENOG4105DQ6 Transposase FORC48_3108 ENOG4107VMI polysaccharide deacetylase FORC48_3109 ENOG4105KY5 gCN5-related N-acetyltransferase FORC48_3110 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FORC48_3112 ENOG4105D6J arsenicaL-resistance protein FORC48_3113 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FORC48_3114 ENOG41085FC arsR family transcriptional regulator FORC48_3116 ENOG4107P5I polyketide synthase FORC48_3117 ENOG4108IG5 Transcriptional regulator FORC48_3126 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC48_3127 ENOG41062D9 Histidine kinase FORC48_3135 ENOG4105DNP FAD linked oxidase domain protein FORC48_3137 ENOG4105C19 ABC transporter FORC48_3143 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FORC48_3144 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC48_3148 ENOG4105K6H D-cysteine desulfhydrase FORC48_3153 ENOG4105JQZ Methyltransferase FORC48_3157 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FORC48_3161 ENOG4105BZU Histidine kinase FORC48_3164 ENOG4108U05 Transcriptional regulator FORC48_3165 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 FORC48_3167 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FORC48_3174 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FORC48_3181 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FORC48_3207 ENOG4108VXD carboxy-peptidase FORC48_3208 ENOG4105PNM synthesis protein FORC48_3210 ENOG4108ISG Major Facilitator FORC48_3213 ENOG4107MII Sugar-specific transcriptional regulator TrmB FORC48_3214 ENOG4105CZM Major Facilitator FORC48_3217 ENOG4105CRW Short chain fatty acid transporter FORC48_3219 ENOG4105DYS nad(p)h dehydrogenase (quinone) FORC48_3231 ENOG4108K8S endonuclease I FORC48_3235 ENOG4108Z66 YbaK ebsC protein FORC48_3236 ENOG4105CUT histidyl-tRNA synthetase FORC48_3239 ENOG4105KVH Transcriptional regulator FORC48_3240 ENOG4108RCM Nitroreductase FORC48_3246 ENOG4108PSK reductase FORC48_3259 ENOG4105C31 Tryptophanyl-tRNA synthetase FORC48_3260 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FORC48_3267 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) FORC48_3269 ENOG4105EV4 Multidrug resistance protein mdtH FORC48_3275 ENOG4105C37 (CBS) domain FORC48_3278 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FORC48_3279 ENOG4105FAW cDP-glucose 4,6-dehydratase FORC48_3281 ENOG4108SMP Nad-dependent epimerase dehydratase FORC48_3286 ENOG4105DDN Pentapeptide repeat-containing protein FORC48_3287 ENOG4105XDF Protein of unknown function (DUF1272) FORC48_3288 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FORC48_3289 ENOG4105CMG Carbohydrate kinase FORC48_3290 ENOG4105C6Z Gluconate FORC48_3291 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FORC48_3293 ENOG4105CV1 Transketolase (EC 2.2.1.1) FORC48_3294 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FORC48_3303 ENOG4105C44 Serine transporter FORC48_3308 ENOG4108TZY GntR Family Transcriptional Regulator FORC48_3309 ENOG4105D9R oxidoreductase FORC48_3318 ENOG4105JAB phenazine biosynthesis protein, phzf family FORC48_3320 ENOG4105CHR reductase FORC48_3322 ENOG4105KNA -acetyltransferase FORC48_3324 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FORC48_3325 ENOG4105KVH Transcriptional regulator FORC48_3328 ENOG4108ZJ4 polysaccharide deacetylase FORC48_3343 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FORC48_3346 ENOG4107YXZ hydrolase, family 25 FORC48_3353 ENOG4105H3G oxidoreductase FORC48_3368 ENOG4108TN2 lmbE family FORC48_3370 ENOG4107R3E Citrate transporter FORC48_3372 ENOG4105WCN acetyltransferase FORC48_3373 ENOG4108MES Periplasmic binding protein FORC48_3374 ENOG4105EHG Permease protein FORC48_3375 ENOG4105DQ5 transport system permease protein FORC48_3376 ENOG4105NX3 Membrane FORC48_3380 ENOG41068WN FORC48_3381 ENOG4107CUJ Protein of unknown function (DUF2690) FORC48_3384 ENOG4107V2S Transcriptional regulator FORC48_3390 ENOG4105C98 muts2 protein FORC48_3391 ENOG4105E5K Alpha-amylase FORC48_3392 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FORC48_3393 ENOG4105DPN Oligoendopeptidase f FORC48_3399 ENOG4108A04 Beta-lactamase FORC48_3404 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FORC48_3407 ENOG41082BM Transcriptional regulator, arsr family FORC48_3408 ENOG4105CIS alcohol dehydrogenase FORC48_3414 ENOG4105CQB FAD linked oxidase domain protein FORC48_3419 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FORC48_3422 ENOG4107TPS domain protein FORC48_3423 ENOG4105CEP NADH dehydrogenase FORC48_3426 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C FORC48_3427 ENOG4108M1A Chitin-binding protein FORC48_3429 ENOG4105E1K spore germination protein FORC48_3433 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FORC48_3435 ENOG4108IAJ Nad-dependent epimerase dehydratase FORC48_3436 ENOG4105FAW cDP-glucose 4,6-dehydratase FORC48_3451 ENOG4105BZU Histidine kinase FORC48_3452 ENOG4105C5H ABC transporter FORC48_3454 ENOG4107DUR UPF0457 protein FORC48_3459 ENOG4105BZU Histidine kinase FORC48_3461 ENOG4105KT7 mgtC SapB transporter FORC48_3463 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FORC48_3465 ENOG41073R8 VanW family FORC48_3467 ENOG4108R1P FORC48_3471 ENOG4105VEQ Cold shock protein FORC48_3475 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FORC48_3479 ENOG410904N short-chain dehydrogenase reductase FORC48_3481 ENOG4106IQC argininosuccinate lyase FORC48_3484 ENOG4108IA2 Sodium pantothenate symporter FORC48_3486 ENOG4105C26 Dehydrogenase FORC48_3487 ENOG4105CHR reductase FORC48_3489 ENOG4105EWU Squalene--hopene cyclase FORC48_3491 ENOG4105FR1 rard protein FORC48_3492 ENOG410696E Membrane FORC48_3495 ENOG4105D1F ATP-binding protein FORC48_3497 ENOG4108ZAF Molybdopterin FORC48_3498 ENOG4105CVM Molybdenum cofactor synthesis domain protein FORC48_3499 ENOG4105D06 uba thif-type nad fad binding protein FORC48_3500 ENOG4105TMB Formate nitrite transporter FORC48_3502 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FORC48_3503 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FORC48_3505 ENOG4108JB9 formate dehydrogenase FORC48_3507 ENOG4105E1K spore germination protein FORC48_3510 ENOG4105CUB amino acid FORC48_3521 ENOG4107QJT sodium dicarboxylate symporter FORC48_3522 ENOG4108KGH TRANSCRIPTIONal FORC48_3524 ENOG4105EMN RNA polymerase sigma factor FORC48_3526 ENOG4105CIG ABC transporter FORC48_3528 ENOG4105D9R oxidoreductase FORC48_3530 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FORC48_3531 ENOG4105K4P CoA-binding domain protein FORC48_3532 ENOG4105C0H protease FORC48_3533 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC48_3535 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FORC48_3536 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FORC48_3537 ENOG4105W8X HesB YadR YfhF-family protein FORC48_3543 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FORC48_3544 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC48_3547 ENOG4105BZ1 (ABC) transporter FORC48_3548 ENOG4108I0Z Aconitate hydratase FORC48_3555 ENOG4105E5W Transporter FORC48_3557 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FORC48_3561 ENOG4107F3J Amp-dependent synthetase and ligase FORC48_3562 ENOG4107ZYJ bioY protein FORC48_3563 ENOG4105CEY Amp-dependent synthetase and ligase FORC48_3572 ENOG4107AYK membrAne FORC48_3575 ENOG4105BZU Histidine kinase FORC48_3576 ENOG4105FBA Phospholipase Carboxylesterase FORC48_3577 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FORC48_3578 ENOG4105CK7 Sodium proline symporter FORC48_3580 ENOG4105CBC glutamate synthase FORC48_3581 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FORC48_3582 ENOG4108VJ1 Transcriptional regulator (CarD family FORC48_3583 ENOG4108903 Formimidoylglutamase FORC48_3594 ENOG4107QIV Cytochrome c biogenesis protein FORC48_3598 ENOG4105CH2 amidohydrolase FORC48_3600 ENOG4105CJ1 ABC, transporter FORC48_3603 ENOG4107RSM transcriptional regulator FORC48_3604 ENOG4105VAW lrga family FORC48_3605 ENOG41067MG lrgb family FORC48_3613 ENOG4105BZ1 (ABC) transporter FORC48_3614 ENOG4105BZ1 (ABC) transporter FORC48_3623 ENOG4105CGH 5'-nucleotidase FORC48_3625 ENOG4108SVB resolvase FORC48_3629 ENOG4105K7K Transcriptional regulator FORC48_3631 ENOG4105DR5 peptidase FORC48_3632 ENOG41065S2 pneumococcal vaccine antigen FORC48_3639 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FORC48_3646 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FORC48_3652 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FORC48_3653 ENOG4105XSJ toxin secretion phage lysis holin FORC48_3691 ENOG4105DVF Cytosine-specific methyltransferase FORC48_3693 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) FORC48_3714 ENOG4105C5F glutamine synthetase FORC48_3715 ENOG4105KV4 Transcriptional regulator FORC48_3716 ENOG4105CXI aluminum resistance protein FORC48_3717 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FORC48_3718 ENOG4105EN6 Membrane FORC48_3720 ENOG4106F1P AAA ATPase, central domain protein FORC48_3726 ENOG41069ER domain protein FORC48_3727 ENOG4105DM4 PTS System FORC48_3728 ENOG4105DE4 1-phosphofructokinase FORC48_3729 ENOG4105E98 transcriptional regulator DeoR family FORC48_3730 ENOG4107QW4 alcohol dehydrogenase FORC48_3731 ENOG4108SJC Membrane FORC48_3734 ENOG4105C85 amino acid FORC48_3737 ENOG4105TMB Formate nitrite transporter FORC48_3738 ENOG4105K70 DNA-binding protein FORC48_3740 ENOG4105C59 p-type ATPase FORC48_3741 ENOG410681U heavy metal transport detoxification protein FORC48_3742 ENOG4105VPX protein, conserved in bacteria FORC48_3744 ENOG4105NIV Esterase FORC48_3745 ENOG4105E0A ABC, transporter FORC48_3751 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FORC48_3752 ENOG4105D03 DNA-3-methyladenine glycosylase II FORC48_3753 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FORC48_3758 ENOG4105BZU Histidine kinase FORC48_3766 ENOG41067MG lrgb family FORC48_3771 ENOG4108S3Y transcriptional regulator FORC48_3772 ENOG4105CS2 ec 3.2.1.21 FORC48_3776 ENOG4105F0V Cell wall hydrolase FORC48_3778 ENOG4105E0M Sulfatase FORC48_3779 ENOG410890F Dynamin family FORC48_3786 ENOG4105DQU oxidoreductase, subunit beta FORC48_3787 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FORC48_3788 ENOG4108IGT Dipeptidase FORC48_3789 ENOG4105MCT stage V sporulation protein S FORC48_3790 ENOG4105D48 metallophosphoesterase FORC48_3794 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FORC48_3797 ENOG4105XZV Protein of unknown function (DUF3243) FORC48_3798 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FORC48_3802 ENOG4105UIB (ABC) transporter FORC48_3803 ENOG4108JQ9 ABC transporter FORC48_3804 ENOG4105DIH basic membrane FORC48_3805 ENOG4105FDP GntR family transcriptional regulator FORC48_3806 ENOG4105CNU cell division protein FtsK FORC48_3808 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FORC48_3810 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FORC48_3812 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FORC48_3813 ENOG4108S0H Dipicolinic acid synthetase, b subunit FORC48_3814 ENOG4105E35 Dipicolinate synthase subunit A FORC48_3816 ENOG4105C1V Peptidase, M16 FORC48_3820 ENOG4105DTN riboflavin biosynthesis protein ribF FORC48_3823 ENOG4105W7A Protein of unknown function (DUF503) FORC48_3825 ENOG4105VHM ribosomal protein FORC48_3826 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FORC48_3827 ENOG4105CHV Transcription elongation factor NusA FORC48_3829 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FORC48_3831 ENOG4105DZP Membrane-associated zinc metalloprotease FORC48_3832 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FORC48_3833 ENOG4105KNE Phosphatidate cytidylyltransferase FORC48_3835 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FORC48_3837 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FORC48_3843 ENOG4108HE4 integrase family FORC48_3845 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FORC48_3846 ENOG4105C79 DNA protecting protein DprA FORC48_3847 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FORC48_3850 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FORC48_3855 ENOG4105VB6 UPF0109 protein FORC48_3859 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FORC48_3860 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FORC48_3863 ENOG4105CHR reductase FORC48_3864 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FORC48_3867 ENOG4105CB5 ATP-dependent DNA helicase recG FORC48_3868 ENOG4105DP4 dak2 domain fusion protein ylov FORC48_3869 ENOG4108ZAA Alkaline-shock protein FORC48_3872 ENOG4105FJ0 thiamine FORC48_3873 ENOG4105DJV ribulose-phosphate 3-epimerase FORC48_3874 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FORC48_3875 ENOG4105D9P serine threonine protein kinase FORC48_3876 ENOG4108ZF3 Phosphatase FORC48_3878 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FORC48_3881 ENOG4105C25 Primosomal protein n' FORC48_3882 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FORC48_3886 ENOG4105DSJ YicC domain protein FORC48_3888 ENOG4105F23 Fibronectin-binding protein FORC48_3889 ENOG4105DC7 peptidase M24 FORC48_3894 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FORC48_3897 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) FORC48_3898 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FORC48_3900 ENOG4105CD3 dihydroorotase FORC48_3904 ENOG4105C34 Pseudouridine synthase FORC48_3907 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FORC48_3909 ENOG4105DBK s4 domain protein FORC48_3910 ENOG41067XK integral membrane protein FORC48_3912 ENOG4105DFA alanine racemase domain protein FORC48_3913 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FORC48_3914 ENOG4105WR5 sporulation protein, YlmC YmxH family FORC48_3916 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC48_3918 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FORC48_3919 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FORC48_3923 ENOG4105D4A Cell wall formation (By similarity) FORC48_3924 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FORC48_3925 ENOG4105CNI cell division protein FtsW FORC48_3928 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FORC48_3929 ENOG4105CJN penicillin-binding protein FORC48_3930 ENOG4105CJN penicillin-binding protein FORC48_3933 ENOG41074B2 UPF0747 protein FORC48_3938 ENOG4105KNH Nucleic acid-binding protein FORC48_3940 ENOG41063PX domain protein FORC48_3941 ENOG4105D78 K07001 NTE family protein FORC48_3942 ENOG4105H20 Sporulation integral membrane protein YlbJ FORC48_3944 ENOG4106H78 methyltransferase FORC48_3948 ENOG4107TB6 phosphoglycerate mutase FORC48_3951 ENOG4106UY4 Inherit from COG: Scp-like extracellular FORC48_3962 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FORC48_3963 ENOG4105CNI cell division protein FtsW FORC48_3966 ENOG4108IAB Phoh family FORC48_3970 ENOG4105QA2 FORC48_3971 ENOG4105CI3 gtp-binding protein typa FORC48_3973 ENOG4105ECY inositol monophosphatase FORC48_3977 ENOG4105CXN decarboxylase FORC48_3987 ENOG4105CPP Dehydrogenase, E1 component FORC48_3990 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FORC48_3991 ENOG4108X4Q Hydrolase FORC48_3993 ENOG4105CN5 Metallo-Beta-Lactamase FORC48_3994 ENOG4107ZYR domain protein FORC48_4001 ENOG4108XRC Protein of unknown function (DUF458) FORC48_4003 ENOG4107IN1 Protein of unknown function (DUF1797) FORC48_4007 ENOG4105EPM Diguanylate phosphodiesterase FORC48_4008 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FORC48_4011 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FORC48_4013 ENOG4105UIN FORC48_4024 ENOG4108HGU Histidine kinase FORC48_4027 ENOG4105CHM Aminotransferase FORC48_4028 ENOG4105FKQ transcriptional regulator FORC48_4029 ENOG4105EG2 ABC transporter, permease FORC48_4031 ENOG4107FKK extracellular solute-binding protein family 1 FORC48_4033 ENOG4105CG3 alpha amylase, catalytic region FORC48_4042 ENOG4105CHU acetyl-coa acetyltransferase FORC48_4049 ENOG4105K7K Transcriptional regulator FORC48_4050 ENOG4105DTD Dehydrogenase FORC48_4054 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FORC48_4059 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FORC48_4062 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FORC48_4064 ENOG4105BZU Histidine kinase FORC48_4068 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FORC48_4071 ENOG4105CID antiterminator FORC48_4073 ENOG4105FDP GntR family transcriptional regulator FORC48_4075 ENOG4105CE4 GlcNAc 6-P deacetylase FORC48_4082 ENOG4107ZE5 PPIases accelerate the folding of proteins FORC48_4083 ENOG4105PTM secreted protein FORC48_4084 ENOG4105J7I hydrolase FORC48_4086 ENOG4105G6R Stage v sporulation protein ae FORC48_4088 ENOG4105CZ3 stage V sporulation protein ad FORC48_4089 ENOG41090VF Stage v sporulation protein ac FORC48_4093 ENOG4105C8J )-transporter FORC48_4094 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC48_4096 ENOG41082AN stage II sporulation protein FORC48_4097 ENOG4105DZ1 carboxypeptidase FORC48_4098 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FORC48_4099 ENOG4105DVE abc transporter atp-binding protein FORC48_4106 ENOG4105D7N magnesium and cobalt transport protein CorA FORC48_4111 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FORC48_4113 ENOG4105I3K Ferric uptake regulator, Fur family FORC48_4114 ENOG4105MZ9 stage II sporulation protein m FORC48_4118 ENOG4105CPC Aldo Keto reductase FORC48_4120 ENOG4105RHY Pfam:UPF0157 FORC48_4124 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FORC48_4126 ENOG4105ETE Transcriptional regulator (LacI family FORC48_4127 ENOG4108YM7 Gcn5-related n-acetyltransferase FORC48_4131 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FORC48_4132 ENOG4108R6K riboflavin synthase, subunit alpha FORC48_4137 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FORC48_4138 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FORC48_4140 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FORC48_4141 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FORC48_4143 ENOG4105DFD Na H antiporter FORC48_4144 ENOG4105CGH 5'-nucleotidase FORC48_4149 ENOG4105DBV ornithine carbamoyltransferase FORC48_4152 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FORC48_4155 ENOG4108IXY short-chain dehydrogenase reductase FORC48_4156 ENOG41069FQ Metallo-beta-lactamase superfamily FORC48_4157 ENOG4105II7 pyrroline-5-carboxylate reductase FORC48_4158 ENOG4105EJQ L-serine dehydratase FORC48_4164 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FORC48_4167 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FORC48_4168 ENOG4105D9U N-acetyltransferase FORC48_4171 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FORC48_4172 ENOG4108QEG Membrane FORC48_4173 ENOG4105CDA abc transporter atp-binding protein FORC48_4174 ENOG4105E5Q amino acid AbC transporter FORC48_4175 ENOG4108HW3 (ABC) transporter FORC48_4177 ENOG4105G7B Protein of unknown function (DUF2992) FORC48_4179 ENOG4108QY0 Membrane FORC48_4181 ENOG4105C7S Dehydrogenase FORC48_4182 ENOG4105CPP Dehydrogenase, E1 component FORC48_4185 ENOG4105CKM Branched-chain carboxylic acid kinase FORC48_4186 ENOG4107RDP Dehydrogenase FORC48_4188 ENOG4108JUB Transcriptional regulator FORC48_4190 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FORC48_4193 ENOG4107QQR Sporulation FORC48_4194 ENOG4105S1Z Stage IV sporulation protein B FORC48_4195 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FORC48_4196 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FORC48_4197 ENOG4105DX0 Hemolysin A FORC48_4199 ENOG4105CTB Polyprenyl synthetase FORC48_4202 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FORC48_4204 ENOG4108ZSR alkaline shock protein FORC48_4205 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FORC48_4210 ENOG410644B Stage III sporulation protein af FORC48_4212 ENOG4105KQ4 Stage iii sporulation protein ad FORC48_4213 ENOG4108CQH stage III sporulation protein AC FORC48_4214 ENOG4105KR5 Stage iii sporulation protein FORC48_4215 ENOG4105CD2 stage iii sporulation protein aa FORC48_4220 ENOG4105DC7 peptidase M24 FORC48_4223 ENOG4105CBJ Metal-dependent enzyme FORC48_4225 ENOG4107YBY Hydrolase FORC48_4228 ENOG4105K7K Transcriptional regulator FORC48_4231 ENOG41082GG biotin lipoate A B protein ligase FORC48_4232 ENOG4105WZW rhodanese family FORC48_4237 ENOG41080TC multidrug resistance protein FORC48_4244 ENOG4105CJ1 ABC, transporter FORC48_4245 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FORC48_4248 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FORC48_4252 ENOG4105C0D helicase FORC48_4277 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FORC48_4278 ENOG4105C3R Methionine synthase FORC48_4281 ENOG4105C28 cystathionine FORC48_4282 ENOG4105C28 cystathionine FORC48_4283 ENOG4105C28 cystathionine FORC48_4287 ENOG4105C5X domain protein FORC48_4289 ENOG4105DKQ ROK family FORC48_4291 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FORC48_4294 ENOG4108UTW Plays a role in the regulation of phosphate uptake FORC48_4295 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FORC48_4296 ENOG4105C8U phosphate abc transporter FORC48_4297 ENOG4105C8U phosphate abc transporter FORC48_4298 ENOG4105EXS phosphate abc transporter FORC48_4299 ENOG4107RF6 penicillin-binding protein FORC48_4301 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FORC48_4306 ENOG4105N80 Ferric uptake regulator, Fur family FORC48_4308 ENOG4105FDK ABC transporter FORC48_4309 ENOG4108JYZ YitT family FORC48_4310 ENOG41069ZM Protein of unknown function (DUF2624) FORC48_4315 ENOG4105EGD dinuclear metal center protein, YbgI family FORC48_4318 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC48_4319 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FORC48_4326 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FORC48_4327 ENOG4105KG3 cytidine deaminase FORC48_4328 ENOG4107YR5 Diacylglycerol kinase FORC48_4330 ENOG4105CTJ Metal Dependent Phosphohydrolase FORC48_4331 ENOG4105C9A Phoh family FORC48_4333 ENOG41068P3 sporulation protein YqfC FORC48_4335 ENOG4105KTH gatB Yqey FORC48_4338 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FORC48_4339 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FORC48_4345 ENOG4105CSA Coproporphyrinogen iii oxidase FORC48_4346 ENOG4105KVH Transcriptional regulator FORC48_4351 ENOG4105TQK DNA polymerase iii, delta' subunit FORC48_4354 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FORC48_4355 ENOG4108UK2 deaminase FORC48_4356 ENOG4105KQC Competence protein FORC48_4358 ENOG4105DXX methyltransferase FORC48_4360 ENOG4108WF2 Metal Dependent Phosphohydrolase FORC48_4362 ENOG410812S Rna-binding protein FORC48_4364 ENOG4105CQW ribosome biogenesis GTPase YqeH FORC48_4365 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FORC48_4368 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC48_4374 ENOG4108TVJ Nitroreductase FORC48_4377 ENOG4105G6Z alkaline phosphatase FORC48_4378 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FORC48_4379 ENOG4108MUZ hydrolase FORC48_4386 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FORC48_4388 ENOG4105MIR Phenylalanine 4-monooxygenase FORC48_4390 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FORC48_4398 ENOG4105S6R Iron-hydroxamate transporter permease subunit FORC48_4399 ENOG4108V5C ABC transporter FORC48_4401 ENOG4108EKI Dehydrogenase FORC48_4402 ENOG4105C28 cystathionine FORC48_4410 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FORC48_4412 ENOG4105CFP Peptidase U32 FORC48_4413 ENOG4105XYU peptidase (U32 family) FORC48_4414 ENOG4108VQJ O-methyltransferase FORC48_4415 ENOG4105HHA aminodeoxychorismate lyase FORC48_4419 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FORC48_4421 ENOG4105C02 permease FORC48_4424 ENOG41060CR FORC48_4425 ENOG4105C7H Helicase, RecD TraA family FORC48_4427 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FORC48_4428 ENOG4105C3J Cysteine desulfurase FORC48_4430 ENOG4105D1H recombination factor protein RarA FORC48_4431 ENOG4108VCI transcription factor, rsfa family FORC48_4432 ENOG4105CUZ uba thif-type nad fad binding protein FORC48_4434 ENOG4105CUT histidyl-tRNA synthetase FORC48_4437 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FORC48_4439 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FORC48_4440 ENOG41076HS cation diffusion facilitator family transporter FORC48_4441 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FORC48_4443 ENOG4105CKP Polysaccharide Biosynthesis Protein FORC48_4444 ENOG4108QG2 Membrane FORC48_4446 ENOG4105VIE preprotein translocase, subunit YajC FORC48_4449 ENOG41061AI Protein of unknown function (DUF2905) FORC48_4452 ENOG4108HUF Transporter FORC48_4458 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FORC48_4459 ENOG4108IYU L-aspartate oxidase FORC48_4462 ENOG4108RPX mosc domain containing protein FORC48_4463 ENOG4105CQC Prephenate dehydratase FORC48_4466 ENOG4105C19 ABC transporter FORC48_4467 ENOG4105EWM Histidine kinase FORC48_4469 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FORC48_4472 ENOG4105X36 (ribosomal) protein FORC48_4474 ENOG4105C03 ribonuclease FORC48_4477 ENOG4107QMS site-determining protein FORC48_4480 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FORC48_4481 ENOG4105DFF Rod shape-determining protein mreb FORC48_4485 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FORC48_4486 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FORC48_4488 ENOG41068KH stage VI sporulation protein D FORC48_4490 ENOG4105D52 delta-aminolevulinic acid dehydratase FORC48_4495 ENOG4105K56 Transcriptional regulator FORC48_4499 ENOG4108IUQ atp-dependent protease FORC48_4506 ENOG4108QCI YvbH-like oligomerisation region FORC48_4508 ENOG4105M59 Phosphodiesterase, mj0936 family FORC48_4509 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FORC48_4511 ENOG4108XJQ germination protein FORC48_4514 ENOG4108PCX Major Facilitator FORC48_4516 ENOG4105KBX Transcriptional regulator, TetR family FORC48_4518 ENOG4105PFC Transcriptional regulator FORC48_4521 ENOG4105DZC cytosine deaminase FORC48_4522 ENOG41067S9 phage shock protein C, PspC FORC48_4523 ENOG4108JCI Transcriptional regulator FORC48_4525 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FORC48_4526 ENOG4108Z40 Transcriptional regulator FORC48_4527 ENOG4105RHA ABC transporter, permease FORC48_4528 ENOG4108IUX (ABC) transporter FORC48_4529 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FORC48_4530 ENOG4105ER2 Ompa motb domain protein FORC48_4531 ENOG4105E14 MotA TolQ exbB proton channel FORC48_4532 ENOG4108VXD carboxy-peptidase FORC48_4534 ENOG4105E33 succinate dehydrogenase FORC48_4536 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FORC48_4538 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FORC48_4539 ENOG4105K63 Thioredoxin FORC48_4540 ENOG4105C10 Electron transfer flavoprotein FORC48_4541 ENOG4105BZJ Electron transfer flavoprotein FORC48_4542 ENOG41060WC Enoyl-CoA hydratase FORC48_4543 ENOG4107Z3H Transcriptional regulator, TetR family FORC48_4544 ENOG4105CEY Amp-dependent synthetase and ligase FORC48_4546 ENOG4105J76 Periplasmic binding protein FORC48_4547 ENOG4105S6R Iron-hydroxamate transporter permease subunit FORC48_4548 ENOG4105S6R Iron-hydroxamate transporter permease subunit FORC48_4558 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC48_4561 ENOG4105DR4 Methyltransferase FORC48_4563 ENOG4105KFN sortase, SrtB family FORC48_4564 ENOG4105E0A ABC, transporter FORC48_4567 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FORC48_4569 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FORC48_4572 ENOG4105FE9 pseudouridine synthase FORC48_4575 ENOG4105DCG PHP domain protein FORC48_4578 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FORC48_4582 ENOG4105C5S asparaginyl-tRNA synthetase FORC48_4583 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FORC48_4585 ENOG4108RWN rrna methyltransferase FORC48_4591 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC48_4592 ENOG4105CW7 secretion protein, HlyD family FORC48_4593 ENOG4108JGH Tetr family transcriptional regulator FORC48_4594 ENOG4105CN9 Peptidase m42 family protein FORC48_4598 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FORC48_4599 ENOG4105C22 threonyL-tRNA synthetase FORC48_4600 ENOG4108TDW sporulation protein YtxC FORC48_4605 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FORC48_4607 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FORC48_4608 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FORC48_4610 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FORC48_4611 ENOG4105C2M dna polymerase I FORC48_4612 ENOG4105BZU Histidine kinase FORC48_4613 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC48_4618 ENOG4108HMX isocitrate dehydrogenase (NADP) FORC48_4619 ENOG4105BZN citrate synthase FORC48_4621 ENOG4108REF Sporulation integral membrane protein ytvi FORC48_4622 ENOG4105FS0 cytoplasmic membrane protein FORC48_4627 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FORC48_4628 ENOG4105C6K Malic enzyme FORC48_4629 ENOG4105C0B DNA polymerase III (alpha subunit) FORC48_4630 ENOG4105VV2 FORC48_4632 ENOG4105SFS phosphoesterase RecJ domain protein FORC48_4637 ENOG4105E8R UPF0173 metal-dependent hydrolase FORC48_4638 ENOG4105DC7 peptidase M24 FORC48_4644 ENOG4105Z7P Acetyltransferase (GNAT) family FORC48_4645 ENOG41082W1 Cupin 2, conserved barrel domain protein FORC48_4649 ENOG4107YZX Universal stress protein FORC48_4658 ENOG4108JYZ YitT family FORC48_4662 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FORC48_4664 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FORC48_4665 ENOG4105KBJ sporulation protein ytfj FORC48_4668 ENOG4105EFZ amidohydrolase FORC48_4670 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FORC48_4675 ENOG4105RQF LysR family Transcriptional regulator FORC48_4677 ENOG4105U5Y Transcriptional regulator FORC48_4679 ENOG4105C28 cystathionine FORC48_4681 ENOG4108IBT Inherit from COG: transposase FORC48_4683 ENOG4108IBT Inherit from COG: transposase FORC48_4689 ENOG4108UW5 maltose o-acetyltransferase FORC48_4691 ENOG4105F1V Acetoin utilization protein FORC48_4692 ENOG4105W87 Cbs domain FORC48_4693 ENOG4105DGU Histone deacetylase FORC48_4696 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC48_4697 ENOG4105BZU Histidine kinase FORC48_4698 ENOG4107SNB ankyrin repeat protein YahD FORC48_4699 ENOG4105EP9 oxidoreductase FORC48_4705 ENOG4105ETE Transcriptional regulator (LacI family FORC48_4706 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FORC48_4710 ENOG4105C88 aminopeptidase FORC48_4717 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FORC48_4719 ENOG4108VDD TRNA binding domain protein FORC48_4725 ENOG4105C8F Beta-lactamase domain protein FORC48_4728 ENOG4108V15 phosphotransferase enzyme family FORC48_4729 ENOG4108IUM Glycogen debranching enzyme FORC48_4731 ENOG4107QSE Dipeptidase FORC48_4732 ENOG4105YW5 deoR family transcriptional regulator FORC48_4735 ENOG4105CBX hi0933 family FORC48_4742 ENOG4108VJ1 Transcriptional regulator (CarD family FORC48_4743 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FORC48_4744 ENOG4105CSC Glucose uptake protein FORC48_4747 ENOG4108ZAF Molybdopterin FORC48_4748 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FORC48_4749 ENOG4105CVM Molybdenum cofactor synthesis domain protein FORC48_4751 ENOG4105D06 uba thif-type nad fad binding protein FORC48_4752 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FORC48_4756 ENOG41085GJ domain protein FORC48_4758 ENOG4105DWV Homoserine O-trans-acetylase FORC48_4760 ENOG4108B31 Spore germination protein FORC48_4767 ENOG410605W Major Facilitator FORC48_4768 ENOG4107S91 Sodium hydrogen exchanger FORC48_4769 ENOG4105NCW Trka-c domain protein FORC48_4772 ENOG4105C19 ABC transporter FORC48_4776 ENOG4105N5T Radical SAM Protein FORC48_4781 ENOG4105E8V Alpha Beta Hydrolase Fold protein FORC48_4782 ENOG4108Z0R Transferase FORC48_4783 ENOG4105YVM Phosphoesterase, PA-phosphatase related FORC48_4784 ENOG4105BZF Glycosyl transferase (Group 1 FORC48_4786 ENOG4105EPU Molybdenum cofactor synthesis domain protein FORC48_4788 ENOG4108MK9 spermidine N(1)-acetyltransferase FORC48_4799 ENOG4105BZU Histidine kinase FORC48_4800 ENOG4105BZU Histidine kinase FORC48_4801 ENOG4105CH6 catalase FORC48_4803 ENOG4107S9D Alpha beta hydrolase FORC48_4809 ENOG4105D2X ABC transporter substrate-binding protein FORC48_4811 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FORC48_4825 ENOG4108V2W Carbonate dehydratase FORC48_4826 ENOG4105C4M (Ubiquinol oxidase) subunit I FORC48_4827 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FORC48_4835 ENOG41087YS Phage shock protein A FORC48_4841 ENOG4105BZU Histidine kinase FORC48_4842 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC48_4847 ENOG4108UGV hypoxanthine phosphoribosyltransferase FORC48_4848 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FORC48_4856 ENOG4107ZTW SNARE associated Golgi FORC48_4859 ENOG4105C19 ABC transporter FORC48_4860 ENOG41086D8 Transcriptional regulator FORC48_4865 ENOG41082BM Transcriptional regulator, arsr family FORC48_4875 ENOG4105C6Z Gluconate FORC48_4876 ENOG4105FDP GntR family transcriptional regulator FORC48_4880 ENOG41069H0 dihydroorotase EC 3.5.2.3 FORC48_4884 ENOG4105DTQ mandelate racemase muconate lactonizing FORC48_4885 ENOG4105CEY Amp-dependent synthetase and ligase FORC48_4886 ENOG4108IPT Naphthoate synthase FORC48_4887 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FORC48_4888 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FORC48_4889 ENOG4105E4F Isochorismate synthase FORC48_4891 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FORC48_4893 ENOG4105VEQ Cold shock protein FORC48_4901 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FORC48_4904 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FORC48_4905 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FORC48_4906 ENOG4105KT7 mgtC SapB transporter FORC48_4907 ENOG4107PBV potassium channel FORC48_4910 ENOG4105WG9 Conserved Protein FORC48_4912 ENOG4105CHM Aminotransferase FORC48_4913 ENOG4108ZB6 transcriptional regulator AsnC family FORC48_4914 ENOG4105C5I Dehydrogenase FORC48_4915 ENOG4108MUZ hydrolase FORC48_4917 ENOG4105C87 Aminotransferase class I and II FORC48_4920 ENOG4105Y38 Kinase-associated protein B FORC48_4922 ENOG4107R3E Citrate transporter FORC48_4925 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FORC48_4926 ENOG4105KA0 thioesterase Superfamily protein FORC48_4930 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FORC48_4935 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) FORC48_4936 ENOG4106YN8 Prenyltransferase FORC48_4938 ENOG41069ER domain protein FORC48_4941 ENOG4105CEP NADH dehydrogenase FORC48_4948 ENOG4105EWC Purine nucleoside phosphorylase FORC48_4953 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FORC48_4958 ENOG4108JJA ABC, transporter FORC48_4959 ENOG4105C4B ABC transporter, permease FORC48_4960 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FORC48_4966 ENOG41083MR nifu domain-containing protein FORC48_4969 ENOG4108W5N phosphatidylglycerophosphatase a FORC48_4973 ENOG4105DAX Pfam:DUF2983 FORC48_4976 ENOG4105DYS nad(p)h dehydrogenase (quinone) FORC48_4977 ENOG4105D4U had-superfamily hydrolase, subfamily iia FORC48_4980 ENOG4105CBT Fructose-1,6-bisphosphatase FORC48_4984 ENOG4105MMD transcriptional regulator FORC48_4985 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FORC48_4986 ENOG4107TXC Transcriptional regulator FORC48_4987 ENOG41090T1 Membrane FORC48_4992 ENOG4105FAA peptidase M23 FORC48_4993 ENOG4108YTE sporulation protein YunB FORC48_4994 ENOG4105KZD Domain of unknown function (DUF1805) FORC48_4995 ENOG4107R8B 5'-nucleotidase FORC48_4996 ENOG4105DIW FeS assembly protein SUFB FORC48_4997 ENOG4108UNV SUF system FeS assembly protein, NifU family FORC48_4998 ENOG4105C9B Cysteine desulfurase FORC48_4999 ENOG4105JRK feS assembly protein SufD FORC48_5000 ENOG4105C3K feS assembly ATPase SufC FORC48_5001 ENOG4105D01 (LipO)protein FORC48_5002 ENOG4105D01 (LipO)protein FORC48_5003 ENOG4108UMI ABC transporter, permease FORC48_5004 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FORC48_5010 ENOG41080E8 Transcriptional regulator, Spx MgsR family FORC48_5014 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FORC48_5022 ENOG4108W8B Beta-lactamase domain protein FORC48_5023 ENOG4105C1G acyl-Coa dehydrogenase FORC48_5025 ENOG4105CHU acetyl-coa acetyltransferase FORC48_5028 ENOG4105DZ1 carboxypeptidase FORC48_5032 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FORC48_5035 ENOG4108SUT Major Facilitator Superfamily FORC48_5036 ENOG4107R7I amino acid FORC48_5040 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FORC48_5042 ENOG4107AYK membrAne FORC48_5050 ENOG4107ZTW SNARE associated Golgi FORC48_5052 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FORC48_5053 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC48_5054 ENOG4105BZU Histidine kinase FORC48_5060 ENOG4105C8Q Methyl-accepting chemotaxis FORC48_5061 ENOG4105VG1 fes assembly suf system protein FORC48_5062 ENOG4105D4Y metalloprotease FORC48_5066 ENOG4107S91 Sodium hydrogen exchanger FORC48_5067 ENOG4105NCW Trka-c domain protein FORC48_5071 ENOG4108RMU ferritin dps family protein FORC48_5074 ENOG4108URH decarboxylase FORC48_5076 ENOG41090A1 ferritin FORC48_5078 ENOG4105D9N nucleoside FORC48_5079 ENOG4105D9N nucleoside FORC48_5082 ENOG4108RYK Nad-dependent epimerase dehydratase FORC48_5085 ENOG4105CV8 reductase FORC48_5086 ENOG4105F27 Major Facilitator FORC48_5087 ENOG4105KVH Transcriptional regulator FORC48_5090 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FORC48_5091 ENOG4105D4A Cell wall formation (By similarity) FORC48_5095 ENOG4105WMR Protein CrcB homolog FORC48_5096 ENOG4105WMR Protein CrcB homolog FORC48_5100 ENOG4105C5H ABC transporter FORC48_5101 ENOG4108MK9 spermidine N(1)-acetyltransferase FORC48_5102 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FORC48_5109 ENOG4108IPW abc transporter atp-binding protein FORC48_5110 ENOG4105CM4 permease protein FORC48_5115 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FORC48_5117 ENOG4105XZU Preprotein translocase, subunit SecG FORC48_5118 ENOG41067MG lrgb family FORC48_5128 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC48_5129 ENOG4105RHA ABC transporter, permease FORC48_5130 ENOG4108IUX (ABC) transporter FORC48_5132 ENOG4105BZU Histidine kinase FORC48_5133 ENOG4108W5X Transcriptional Regulator, LuxR family FORC48_5136 ENOG41090VF Stage v sporulation protein ac FORC48_5137 ENOG4105CZ3 stage V sporulation protein ad FORC48_5140 ENOG4108QY0 Membrane FORC48_5141 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FORC48_5142 ENOG4105KRI phosphocarrier protein (HPr FORC48_5144 ENOG4105CHW UPF0052 protein FORC48_5145 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FORC48_5146 ENOG4108Z4K mutator MutT protein FORC48_5148 ENOG4105C3M thioredoxin reductase FORC48_5150 ENOG4108S4C acetyltransferase FORC48_5152 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) FORC48_5154 ENOG41086DT Membrane protein of unknown function FORC48_5156 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FORC48_5157 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FORC48_5160 ENOG4107TXC Transcriptional regulator FORC48_5163 ENOG4105HMI Membrane FORC48_5164 ENOG4105DUM transcriptional regulator, lysR family FORC48_5166 ENOG4108WS4 fmn reductase FORC48_5169 ENOG4105BZ1 (ABC) transporter FORC48_5171 ENOG4105CN1 protease FORC48_5172 ENOG4105CRP Part of the ABC transporter FtsEX involved in FORC48_5173 ENOG4105CAK Cell division ATP-binding protein ftsE FORC48_5178 ENOG4105MS2 ribosomal subunit Interface protein FORC48_5180 ENOG4105VEQ Cold shock protein FORC48_5181 ENOG41081UC Inherit from COG: Competence protein FORC48_5185 ENOG4105KVH Transcriptional regulator FORC48_5188 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FORC48_5189 ENOG4108KGH TRANSCRIPTIONal FORC48_5190 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FORC48_5191 ENOG4105C6Y Udp-glucose 6-dehydrogenase FORC48_5192 ENOG4105ESV Glycosyl transferase, family 4 FORC48_5194 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FORC48_5198 ENOG4105F8D glycoside hydrolase family 4 FORC48_5199 ENOG4105VCP PTS System FORC48_5200 ENOG4105CK1 PTS System FORC48_5202 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FORC48_5203 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FORC48_5204 ENOG4105VCP PTS System FORC48_5206 ENOG4105VZJ PTS System FORC48_5210 ENOG4105ECB domain protein FORC48_5211 ENOG4107RSM transcriptional regulator FORC48_5221 ENOG4105DAA L-lactate FORC48_5223 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FORC48_5225 ENOG4105E0M Sulfatase FORC48_5234 ENOG4107R8N Glycosyl transferase, family 2 FORC48_5236 ENOG4105C94 Transporter FORC48_5237 ENOG41069ER domain protein FORC48_5242 ENOG4105KBK Zinc finger, swim domain protein FORC48_5243 ENOG4105C0D helicase FORC48_5249 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC48_5251 ENOG4107RBB ABC transporter, permease FORC48_5252 ENOG4105C19 ABC transporter FORC48_5256 ENOG4105CXY transporter FORC48_5259 ENOG4105BZU Histidine kinase FORC48_5260 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC48_5262 ENOG4108KGH TRANSCRIPTIONal FORC48_5264 ENOG4105C6Y Udp-glucose 6-dehydrogenase FORC48_5270 ENOG4108KMV Glycosyl transferase (Group 1 FORC48_5273 ENOG4105C5I Dehydrogenase FORC48_5275 ENOG4105D3Q Sugar transferase FORC48_5277 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FORC48_5278 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FORC48_5279 ENOG4107YJ4 chain length determinant protein FORC48_5280 ENOG4105HTX biosynthesis protein FORC48_5281 ENOG4107YJ4 chain length determinant protein FORC48_5284 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FORC48_5286 ENOG4105FRN stage II sporulation protein FORC48_5289 ENOG4105DY9 regulatoR FORC48_5293 ENOG4106778 Protein of unknown function (DUF1146) FORC48_5294 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FORC48_5295 ENOG4105C8S subunit m FORC48_5296 ENOG4105D65 subunit l FORC48_5301 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FORC48_5302 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FORC48_5304 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FORC48_5305 ENOG4105BZU Histidine kinase FORC48_5316 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FORC48_5317 ENOG41062M3 atp synthase FORC48_5321 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FORC48_5322 ENOG4108UIC UPF0340 protein FORC48_5323 ENOG4108YZG isomerase FORC48_5326 ENOG4108VGI doxx family FORC48_5327 ENOG4107XC4 flavin reductase domain protein, FMN-binding FORC48_5331 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FORC48_5333 ENOG4108ZXQ stage ii sporulation protein r FORC48_5334 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FORC48_5335 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FORC48_5336 ENOG4107104 thymidine kinase FORC48_5338 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FORC48_5339 ENOG4105CBT Fructose-1,6-bisphosphatase FORC48_5341 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FORC48_5345 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FORC48_5348 ENOG4105C1G acyl-Coa dehydrogenase FORC48_5349 ENOG4105C1G acyl-Coa dehydrogenase FORC48_5350 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FORC48_5352 ENOG4105DF6 Fe-S oxidoreductase FORC48_5355 ENOG4105BZU Histidine kinase FORC48_5358 ENOG4105D4Y metalloprotease FORC48_5360 ENOG4105BZU Histidine kinase FORC48_5361 ENOG4105KCT ABC transporter FORC48_5362 ENOG4108M15 ABC transporter FORC48_5363 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FORC48_5365 ENOG4105IIU Aminopeptidase FORC48_5369 ENOG4105DU6 RNA polymerase FORC48_5371 ENOG410684U Domain of unknown function (DUF1934) FORC48_5376 ENOG4105CYW agmatinase FORC48_5378 ENOG4105DXB Major Facilitator superfamily FORC48_5379 ENOG4107SWG transcriptional regulator MERR family FORC48_5381 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FORC48_5382 ENOG4105BZ4 penicillin-binding protein FORC48_5383 ENOG4108XFG YwhD family FORC48_5384 ENOG4108Z4T Peptidase M50 FORC48_5386 ENOG41069HH 4-oxalocrotonate tautomerase FORC48_5387 ENOG4105DCI Phosphohydrolase FORC48_5388 ENOG4108MES Periplasmic binding protein FORC48_5389 ENOG4105E0A ABC, transporter FORC48_5390 ENOG4105EHG Permease protein FORC48_5391 ENOG4105DQ5 transport system permease protein FORC48_5393 ENOG4108VCI transcription factor, rsfa family FORC48_5394 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) FORC48_5395 ENOG4108IJ2 phosphate acetyltransferase FORC48_5396 ENOG4107UEZ chlorite dismutase FORC48_5398 ENOG4108VKI Cell wall hydrolase FORC48_5402 ENOG4107SVH Potassium channel protein FORC48_5404 ENOG410667J hydrolase FORC48_5405 ENOG4105VCH membrane FORC48_5407 ENOG4108TU7 Inherit from COG: (ABC) transporter FORC48_5408 ENOG4105CJ1 ABC, transporter FORC48_5409 ENOG41090WU lipolytic protein G-D-S-L family FORC48_5412 ENOG4105D6E homoserine dehydrogenase FORC48_5417 ENOG4108Y4K DNA-binding transcriptional activator FORC48_5419 ENOG4105WH1 Two component transcriptional regulator luxr family FORC48_5420 ENOG4105BZU Histidine kinase FORC48_5421 ENOG4105DWF phosphomethylpyrimidine kinase FORC48_5422 ENOG4105BZU Histidine kinase FORC48_5423 ENOG4105VCD cytoplasmic protein FORC48_5424 ENOG4105D22 carbon starvation protein FORC48_5425 ENOG4105DY9 regulatoR FORC48_5426 ENOG41079KZ Major Facilitator Superfamily FORC48_5429 ENOG4105CG5 Glycosyl transferase (Group 1 FORC48_5431 ENOG4105EN6 Membrane FORC48_5432 ENOG4106YBV Methyl-accepting chemotaxis FORC48_5434 ENOG4108S4H thioesterase Superfamily protein FORC48_5436 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) FORC48_5438 ENOG4105K64 Glycosyl transferase, family 2 FORC48_5440 ENOG4105EJV Membrane FORC48_5441 ENOG4105CKK Glycosyl transferase, family 2 FORC48_5442 ENOG4105C5H ABC transporter FORC48_5443 ENOG41067SE Tetr family transcriptional regulator FORC48_5445 ENOG4105E0X reductase FORC48_5446 ENOG4106F5Q Membrane FORC48_5449 ENOG4108NEV two component transcriptional regulator, LytTR family FORC48_5450 ENOG4108HRK Histidine kinase FORC48_5451 ENOG4107RGD Major Facilitator superfamily FORC48_5454 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FORC48_5456 ENOG4105IW1 AmiS UreI transporter FORC48_5457 ENOG4105CMR udp-glucose 4-epimerase FORC48_5458 ENOG4108UT2 hemolysin iii FORC48_5460 ENOG4105C1J atp-dependent rna helicase FORC48_5461 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) FORC48_5462 ENOG4105DPN Oligoendopeptidase f FORC48_5464 ENOG4105BZU Histidine kinase FORC48_5465 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) FORC48_5467 ENOG4105C0H protease FORC48_5468 ENOG4105Q2H domain protein FORC48_5471 ENOG4105BZU Histidine kinase FORC48_5472 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC48_5473 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FORC48_5474 ENOG4105CDU Replicative dna helicase FORC48_5476 ENOG4105BZR domain protein FORC48_5477 ENOG4108XMW Membrane FORC48_5479 ENOG4108UUM single-stranded DNA-binding protein FORC48_5481 ENOG4105C3G gtp-binding protein FORC48_5482 ENOG4105VDK protein, conserved in bacteria FORC48_5483 ENOG4105D8X mechanosensitive ion channel FORC48_5484 ENOG4108ZDA Sporulation protein YyaC FORC48_5485 ENOG4105FA0 parb-like partition protein FORC48_5486 ENOG4107QJE Chromosome Partitioning Protein FORC48_5489 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FORC48_5490 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FORC48_5492 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FORC48_t098 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation