locus-tag class description FORC086_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FORC086_00015 ENOG410848D S4 domain protein YaaA FORC086_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FORC086_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FORC086_00100 ENOG4105ZMH deoxynucleoside kinase FORC086_00110 ENOG4105GTG Isochorismatase FORC086_00120 ENOG4108Z6B deaminase FORC086_00130 ENOG4105C6E dna polymerase iii FORC086_00150 ENOG41067KS pro-sigma K processing FORC086_00185 ENOG4105CXN decarboxylase FORC086_00195 ENOG4105FA2 dna polymerase iii FORC086_00200 ENOG4105MA4 psp1 domain protein FORC086_00210 ENOG41060K3 Methyltransferase FORC086_00220 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FORC086_00225 ENOG4105KRN Transcriptional regulator, abrb family FORC086_00230 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FORC086_00235 ENOG4105F8V Hydrolase, tatD family FORC086_00240 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FORC086_00250 ENOG4105XFA sporulation peptidase YabG FORC086_00255 ENOG4105W42 Veg protein FORC086_00270 ENOG4105DFT pur operon repressor FORC086_00280 ENOG4105KME endoribonuclease L-psp FORC086_00295 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FORC086_00300 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FORC086_00310 ENOG4108JA2 transcriptioN-repair coupling factor FORC086_00315 ENOG4108M14 stage v sporulation protein t FORC086_00325 ENOG4108IY2 MazG family FORC086_00330 ENOG41082I2 s4 domain protein FORC086_00335 ENOG4105VYY sporulation protein yabp FORC086_00350 ENOG41060GV RNA binding s1 domain protein FORC086_00370 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FORC086_00375 ENOG4108UGV hypoxanthine phosphoribosyltransferase FORC086_00380 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FORC086_00395 ENOG4105C6T cysteine synthase FORC086_00400 ENOG4105CRQ synthase (Component I) FORC086_00405 ENOG4105DDQ anthranilate synthase FORC086_00410 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FORC086_00415 ENOG4105EEI dihydropteroate synthase FORC086_00420 ENOG4105KRF dihydroneopterin aldolase FORC086_00425 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FORC086_00435 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FORC086_00525 ENOG4108Z0C Uvrb UvrC protein FORC086_00540 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FORC086_00550 ENOG4105CTP PilT protein domain protein FORC086_00555 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FORC086_00570 ENOG4105D7W serine acetyltransferase FORC086_00585 ENOG4105C2N RNA methyltransferase TrmH family group 3 FORC086_00590 ENOG4105M0M Tetracycline resistance protein FORC086_00595 ENOG4105QIV RNA polymerase FORC086_00610 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FORC086_00635 ENOG4107Y49 methyltransferase FORC086_00650 ENOG4105XPM ribosomal protein FORC086_00760 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FORC086_00785 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FORC086_00795 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FORC086_00805 ENOG41067V7 50S ribosomal protein L36 FORC086_00830 ENOG4108JJB ABC transporter FORC086_00835 ENOG4108JJB ABC transporter FORC086_00840 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FORC086_00845 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FORC086_00870 ENOG4105D1F ATP-binding protein FORC086_00885 ENOG4108NMV polysaccharide deacetylase FORC086_00965 ENOG4105C8B TIGR00159 family FORC086_00970 ENOG4107U5W ybbr family FORC086_00985 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FORC086_01020 ENOG4108PSK reductase FORC086_01025 ENOG4108UMI ABC transporter, permease FORC086_01030 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FORC086_01035 ENOG4105D01 (LipO)protein FORC086_01040 ENOG4105CB2 alcohol dehydrogenase FORC086_01050 ENOG4105IQ5 FAD linked oxidase domain protein FORC086_01065 ENOG4105C2C drug resistance transporter, Bcr CflA FORC086_01080 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FORC086_01085 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC086_01090 ENOG4105C3U ABC transporter FORC086_01095 ENOG4108JQ7 (ABC) transporter FORC086_01125 ENOG4108J59 Extracellular solute-binding protein, family 5 FORC086_01130 ENOG4108J59 Extracellular solute-binding protein, family 5 FORC086_01140 ENOG4105II7 pyrroline-5-carboxylate reductase FORC086_01150 ENOG4105E0C molybdate abc transporter FORC086_01155 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FORC086_01160 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FORC086_01175 ENOG4105EGI Transcriptional regulator FORC086_01200 ENOG4105F6E Acyl-transferase FORC086_01225 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FORC086_01245 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FORC086_01270 ENOG4105C5H ABC transporter FORC086_01285 ENOG4105DEF Extracellular solute-binding protein, family 5 FORC086_01295 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC086_01300 ENOG4105C3U ABC transporter FORC086_01305 ENOG4108JQ7 (ABC) transporter FORC086_01310 ENOG410667J hydrolase FORC086_01340 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FORC086_01345 ENOG4105ERH Fumarylacetoacetate hydrolase FORC086_01355 ENOG4105CUB amino acid FORC086_01360 ENOG4108SC4 )-transporter FORC086_01365 ENOG4105CPF Cell wall formation (By similarity) FORC086_01370 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FORC086_01395 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FORC086_01400 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FORC086_01410 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FORC086_01515 ENOG4105K8N protein family UPF0079, ATPase FORC086_01520 ENOG41072GX Peptidase M22 Glycoprotease FORC086_01525 ENOG410801F ribosomal-protein-alanine acetyltransferase FORC086_01530 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FORC086_01535 ENOG4105C5H ABC transporter FORC086_01550 ENOG4108TYN CAAX amino terminal protease family protein FORC086_01570 ENOG4105C7N Xanthine uracil vitamin C permease FORC086_01580 ENOG4105BZU Histidine kinase FORC086_01610 ENOG4107ZXU DSBA oxidoreductase FORC086_01660 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC086_01690 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FORC086_01700 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) FORC086_01710 ENOG4108SHN Glycosyl transferase, family 2 FORC086_01730 ENOG4105SX7 Transporter FORC086_01760 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FORC086_01765 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FORC086_01770 ENOG4105C83 adenylosuccinate lyase FORC086_01780 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FORC086_01805 ENOG4108V3E phosphoribosylglycinamide formyltransferase FORC086_01815 ENOG4105C12 Phosphoribosylglycinamide synthetase FORC086_01845 ENOG4105C4R Atp-dependent dna helicase FORC086_01870 ENOG4108W2Y isochorismatase FORC086_01875 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FORC086_01880 ENOG4108UMI ABC transporter, permease FORC086_01885 ENOG4105D01 (LipO)protein FORC086_01905 ENOG410834F Transcriptional regulator FORC086_01910 ENOG4107I77 yiaA/B two helix domain FORC086_01930 ENOG4105CBD Diacylglycerol kinase FORC086_01940 ENOG4108JPW Aminotransferase FORC086_01950 ENOG4105C26 Dehydrogenase FORC086_01955 ENOG4105KPY Small multidrug resistance protein FORC086_01980 ENOG4105D9N nucleoside FORC086_01985 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FORC086_01995 ENOG4108W15 Protein of unknown function (DUF1456) FORC086_02010 ENOG4105DTQ mandelate racemase muconate lactonizing FORC086_02020 ENOG4105DFD Na H antiporter FORC086_02040 ENOG4105D3R alkyl hydroperoxide reductase FORC086_02045 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FORC086_02050 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FORC086_02055 ENOG4107W7X Aldolase FORC086_02060 ENOG4105EHG Permease protein FORC086_02065 ENOG4105DQ5 transport system permease protein FORC086_02070 ENOG4108V5C ABC transporter FORC086_02080 ENOG4105CAY ferredoxin--nadp reductase FORC086_02100 ENOG4106UIA FORC086_02105 ENOG4106UIA FORC086_02120 ENOG4105BZU Histidine kinase FORC086_02140 ENOG410756H nucleotidyltransferase FORC086_02145 ENOG4105D2S major facilitator superfamily FORC086_02160 ENOG4105E5Q amino acid AbC transporter FORC086_02165 ENOG4105EAB amino acid AbC transporter FORC086_02180 ENOG4105C8Q Methyl-accepting chemotaxis FORC086_02195 ENOG4105DBV ornithine carbamoyltransferase FORC086_02205 ENOG4105C5B carbamate kinase FORC086_02210 ENOG4108W63 CRP FNR family transcriptional regulator FORC086_02220 ENOG4105DNP FAD linked oxidase domain protein FORC086_02230 ENOG4105CI1 PTS System FORC086_02245 ENOG4105C9U ATP-dependent DNA helicase RecQ FORC086_02260 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FORC086_02280 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FORC086_02330 ENOG41062JF Transcriptional regulator FORC086_02345 ENOG4105DEU major facilitator superfamily FORC086_02360 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FORC086_02375 ENOG4108N0M stress protein FORC086_02380 ENOG4106FN3 tellurium resistance protein FORC086_02385 ENOG4106FN3 tellurium resistance protein FORC086_02390 ENOG4107TS3 membrane protein, TerC FORC086_02395 ENOG4108TTB tellurium resistance protein FORC086_02415 ENOG41068PA UPF0435 protein FORC086_02420 ENOG4105KJF protein tyrosine phosphatase FORC086_02430 ENOG4107U9T Pfam:Ribonuclease_BN FORC086_02440 ENOG4105C59 p-type ATPase FORC086_02445 ENOG4108IPJ Membrane FORC086_02465 ENOG4107ZTW SNARE associated Golgi FORC086_02480 ENOG410606W general stress protein FORC086_02485 ENOG4105UPD Calcium Proton FORC086_02520 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FORC086_02525 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FORC086_02535 ENOG4108JUB Transcriptional regulator FORC086_02545 ENOG4108IQI permease FORC086_02595 ENOG4108A04 Beta-lactamase FORC086_02610 ENOG4105CKK Glycosyl transferase, family 2 FORC086_02615 ENOG4107QQG Dehydrogenase FORC086_02620 ENOG4105C3I Nad-dependent epimerase dehydratase FORC086_02640 ENOG4105F1A Pyruvate formate-lyase FORC086_02660 ENOG4105CI2 imidazolone-5-propionate hydrolase FORC086_02665 ENOG4105ECP epimerase FORC086_02695 ENOG41067AE Membrane-bound metal-dependent hydrolase FORC086_02700 ENOG4105CEN a g-specific adenine glycosylase FORC086_02705 ENOG4106BXE FORC086_02725 ENOG4105BZ1 (ABC) transporter FORC086_02730 ENOG4107NBY Membrane FORC086_02735 ENOG4105CBC glutamate synthase FORC086_02745 ENOG4108IUW ABC transporter FORC086_02765 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC086_02770 ENOG4105G5W regulator Fur family FORC086_02885 ENOG4105CDY transcriptional regulatory protein FORC086_02895 ENOG4108JQC penicillin-binding protein 1A FORC086_02900 ENOG4108R9S DSBA oxidoreductase FORC086_02910 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FORC086_02920 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FORC086_02925 ENOG4105BZU Histidine kinase FORC086_02935 ENOG4105CYN Serine protein kinase FORC086_02990 ENOG4105EWM Histidine kinase FORC086_03060 ENOG4105C94 Transporter FORC086_03075 ENOG4105DZ6 Band 7 protein FORC086_03085 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FORC086_03090 ENOG4108V9W transcriptional regulatory protein FORC086_03095 ENOG4105D4T Citrate transporter FORC086_03120 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FORC086_03125 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC086_03130 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FORC086_03135 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FORC086_03140 ENOG4105BZ7 extracellular solute-binding protein family 1 FORC086_03145 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FORC086_03150 ENOG4108STX response regulator FORC086_03155 ENOG41062D9 Histidine kinase FORC086_03180 ENOG4108MRH transcriptional regulatory protein FORC086_03190 ENOG4105C6K Malic enzyme FORC086_03200 ENOG4108UZ3 Transporter FORC086_03205 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC086_03215 ENOG4105BZU Histidine kinase FORC086_03230 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FORC086_03235 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FORC086_03240 ENOG4108JB9 formate dehydrogenase FORC086_03265 ENOG4105CUB amino acid FORC086_03280 ENOG4105C59 p-type ATPase FORC086_03285 ENOG4105DAP Nicotinate phosphoribosyltransferase FORC086_03315 ENOG41073R8 VanW family FORC086_03320 ENOG4108KGH TRANSCRIPTIONal FORC086_03325 ENOG4105D9N nucleoside FORC086_03330 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FORC086_03335 ENOG4105C37 (CBS) domain FORC086_03340 ENOG4108IJ0 Aspartate ammonia-lyase FORC086_03345 ENOG4105DAA L-lactate FORC086_03360 ENOG4105DUX Transporter FORC086_03365 ENOG4108MES Periplasmic binding protein FORC086_03370 ENOG4105DQ5 transport system permease protein FORC086_03375 ENOG4108IHU transport system permease protein FORC086_03380 ENOG4105E0A ABC, transporter FORC086_03385 ENOG4105DMQ Methyltransferase FORC086_03390 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FORC086_03395 ENOG4105EXW epimerase dehydratase FORC086_03405 ENOG4107T89 von Willebrand factor, type A FORC086_03410 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FORC086_03415 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FORC086_03425 ENOG4105BZU Histidine kinase FORC086_03430 ENOG4105D5Q Arginine ornithine antiporter FORC086_03435 ENOG4107414 GntR family transcriptional regulator FORC086_03440 ENOG4105C5Y PTS System FORC086_03445 ENOG4105CG3 alpha amylase, catalytic region FORC086_03460 ENOG4105E1K spore germination protein FORC086_03465 ENOG4105CRN Aminoglycoside phosphotransferase FORC086_03470 ENOG4105BZG amino acid carrier protein FORC086_03480 ENOG4105CDA abc transporter atp-binding protein FORC086_03485 ENOG4105CT1 (ABC) transporter FORC086_03490 ENOG4105EAD ABC transporter FORC086_03495 ENOG4105DRP amino acid AbC transporter FORC086_03500 ENOG4108IQI permease FORC086_03515 ENOG4105D29 Helix-turn-helix type 11 domain protein FORC086_03520 ENOG4105NAE bifunctional deaminase-reductase domain protein FORC086_03530 ENOG4105BZU Histidine kinase FORC086_03555 ENOG4105CHH sulfate transporter FORC086_03560 ENOG41068KF Universal stress protein FORC086_03570 ENOG4105CXY transporter FORC086_03575 ENOG41067TZ transcriptional regulator, MarR family FORC086_03580 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC086_03585 ENOG4105ETE Transcriptional regulator (LacI family FORC086_03590 ENOG4108RVA ribokinase FORC086_03600 ENOG4105C2J ABC transporter FORC086_03605 ENOG4105CNN ABC, transporter FORC086_03610 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FORC086_03615 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FORC086_03655 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) FORC086_03685 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FORC086_03690 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FORC086_03695 ENOG41069ER domain protein FORC086_03700 ENOG4105VZ8 Transcriptional regulator FORC086_03705 ENOG4107D63 FORC086_03720 ENOG4105DUX Transporter FORC086_03740 ENOG4105C85 amino acid FORC086_03745 ENOG4105C7N Xanthine uracil vitamin C permease FORC086_03755 ENOG4105D7V transposase FORC086_03770 ENOG4105MA6 gCN5-related N-acetyltransferase FORC086_03790 ENOG4105CCU oxidase (Subunit III) FORC086_03795 ENOG4105BZ9 Cytochrome C oxidase, subunit I FORC086_03800 ENOG4105E2S oxidase) subunit II FORC086_03820 ENOG4106CAD Protein of unknown function (DUF3311) FORC086_03825 ENOG4105E1V na solute symporter FORC086_03840 ENOG4108NHD germination protein FORC086_03850 ENOG4105CE1 Ferrous iron transport protein b FORC086_03855 ENOG4105CE1 Ferrous iron transport protein b FORC086_03860 ENOG4105CE1 Ferrous iron transport protein b FORC086_03865 ENOG4105CVA phosphate FORC086_03870 ENOG4105C8U phosphate abc transporter FORC086_03875 ENOG4105E2Z phosphate ABC transporter (Permease FORC086_04005 ENOG41080XQ Signal transduction protein with cbs domains FORC086_04030 ENOG4105ETU transcriptional activator (TenA FORC086_04040 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FORC086_04050 ENOG4108VEU Thiamine monophosphate synthase FORC086_04055 ENOG41080HI glycine oxidase FORC086_04070 ENOG4105D06 uba thif-type nad fad binding protein FORC086_04075 ENOG4105DWF phosphomethylpyrimidine kinase FORC086_04130 ENOG4108INS Transcriptional regulator FORC086_04140 ENOG4105C7N Xanthine uracil vitamin C permease FORC086_04150 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FORC086_04170 ENOG4105C5Y PTS System FORC086_04185 ENOG4105K63 Thioredoxin FORC086_04205 ENOG4108B31 Spore germination protein FORC086_04225 ENOG4107Y03 Nitroreductase FORC086_04230 ENOG4105ED1 spovr family FORC086_04240 ENOG4108TCS Glutamyl endopeptidase FORC086_04270 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FORC086_04275 ENOG4105XTG Pfam:DUF156 FORC086_04280 ENOG4105VFE sira family FORC086_04285 ENOG4107TPS domain protein FORC086_04290 ENOG4105VFE sira family FORC086_04295 ENOG4105VFE sira family FORC086_04300 ENOG41085GJ domain protein FORC086_04305 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FORC086_04310 ENOG41087NI Sulfite exporter TauE/SafE FORC086_04320 ENOG4108KGH TRANSCRIPTIONal FORC086_04345 ENOG4105EMD TRANSCRIPTIONal FORC086_04350 ENOG4105VCP PTS System FORC086_04355 ENOG4105VZJ PTS System FORC086_04380 ENOG41069ER domain protein FORC086_04385 ENOG4107RBB ABC transporter, permease FORC086_04390 ENOG4105C19 ABC transporter FORC086_04420 ENOG4105WEF catalase FORC086_04455 ENOG4107T5V SNARE associated Golgi FORC086_04490 ENOG4105CUB amino acid FORC086_04495 ENOG4107RWR Sodium hydrogen exchanger FORC086_04505 ENOG4106KNT transcriptional regulator FORC086_04545 ENOG4108YXU transcriptional regulator AsnC family FORC086_04555 ENOG4108IXY short-chain dehydrogenase reductase FORC086_04565 ENOG4105KPY Small multidrug resistance protein FORC086_04600 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FORC086_04605 ENOG4105E5W Transporter FORC086_04615 ENOG4107RKG DJ-1/PfpI family FORC086_04620 ENOG4105CH6 catalase FORC086_04630 ENOG4105D5Q Arginine ornithine antiporter FORC086_04635 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FORC086_04645 ENOG4105C26 Dehydrogenase FORC086_04665 ENOG4105BZ1 (ABC) transporter FORC086_04670 ENOG4105BZ1 (ABC) transporter FORC086_04685 ENOG4105DRP amino acid AbC transporter FORC086_04690 ENOG4105CDA abc transporter atp-binding protein FORC086_04705 ENOG410839P FORC086_04745 ENOG4107FQX Alpha-acetolactate decarboxylase FORC086_04765 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FORC086_04770 ENOG4105D4P Coproporphyrinogen iii oxidase FORC086_04775 ENOG4105CEY Amp-dependent synthetase and ligase FORC086_04790 ENOG4105CHH sulfate transporter FORC086_04820 ENOG4105CGU Enoyl-CoA hydratase FORC086_04840 ENOG4105DER m42 family FORC086_04860 ENOG4105CTU Proline racemase FORC086_04865 ENOG4105CIF Ornithine Cyclodeaminase FORC086_04880 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC086_04885 ENOG4105C3U ABC transporter FORC086_04890 ENOG4108JQ7 (ABC) transporter FORC086_04970 ENOG4108IBT Inherit from COG: transposase FORC086_05005 ENOG4108IBT Inherit from COG: transposase FORC086_05020 ENOG4105CSH Transporter FORC086_05030 ENOG4108MRH transcriptional regulatory protein FORC086_05085 ENOG4105CDU Replicative dna helicase FORC086_05115 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC086_05130 ENOG4105D9U N-acetyltransferase FORC086_05140 ENOG4105F6J Alpha beta hydrolase fold FORC086_05190 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FORC086_05210 ENOG4105CMT Dihydroxyacetone kinase FORC086_05225 ENOG4105CMT Dihydroxyacetone kinase FORC086_05270 ENOG41069ER domain protein FORC086_05355 ENOG4105WN5 stage II sporulation protein FORC086_05365 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC086_05375 ENOG4108MJI response regulator FORC086_05380 ENOG4105BZU Histidine kinase FORC086_05385 ENOG4105BZU Histidine kinase FORC086_05410 ENOG4105K8R UPF0145 protein FORC086_05430 ENOG4107QHE Choloylglycine hydrolase FORC086_05450 ENOG4107VRP DNA repair exonuclease FORC086_05455 ENOG4106D4I domain protein FORC086_05485 ENOG4108MUZ hydrolase FORC086_05505 ENOG4105F0F Oxalate decarboxylase FORC086_05515 ENOG41067QW Transcriptional regulator FORC086_05520 ENOG4105D7V transposase FORC086_05525 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FORC086_05540 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FORC086_05560 ENOG4105DU6 RNA polymerase FORC086_05580 ENOG4105EEM helicase FORC086_05590 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC086_05620 ENOG4105K59 histidine triad (HIT) protein FORC086_05660 ENOG410905X membrane-flanked domain protein FORC086_05665 ENOG4105CKV Membrane FORC086_05705 ENOG410905X membrane-flanked domain protein FORC086_05710 ENOG4105CKV Membrane FORC086_05715 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FORC086_05720 ENOG4105BZ4 penicillin-binding protein FORC086_05730 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FORC086_05735 ENOG4105C1Q protoporphyrinogen oxidase FORC086_05760 ENOG4105NA0 Transcriptional regulator FORC086_05775 ENOG4105ECB domain protein FORC086_05775 ENOG4105ECB domain protein FORC086_05795 ENOG4108MK9 spermidine N(1)-acetyltransferase FORC086_05805 ENOG4106AXD FORC086_05810 ENOG4108RQ5 Beta-lactamase domain-containing protein FORC086_05815 ENOG4105DF9 Lipoate-protein, ligase FORC086_05825 ENOG4105CEY Amp-dependent synthetase and ligase FORC086_05835 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FORC086_05840 ENOG4108I5D sulfate abc transporter FORC086_05845 ENOG4105ECW sulfate abc transporter FORC086_05850 ENOG4108IJ6 ABC transporter FORC086_05855 ENOG4105CNA YD repeat protein FORC086_05910 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) FORC086_05920 ENOG4107RN3 metallophosphoesterase FORC086_05925 ENOG4107TVP HD domain protein FORC086_05935 ENOG4108AEY RNA polymerase sigma factor FORC086_05940 ENOG41086D8 Transcriptional regulator FORC086_05955 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC086_05975 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FORC086_05980 ENOG4105C8Q Methyl-accepting chemotaxis FORC086_05985 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) FORC086_05995 ENOG4107QP3 malate synthase g FORC086_06015 ENOG4105VEQ Cold shock protein FORC086_06050 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FORC086_06095 ENOG4105ERH Fumarylacetoacetate hydrolase FORC086_06105 ENOG4105C8Y Acetylornithine aminotransferase FORC086_06110 ENOG4106BKT UPF0344 protein FORC086_06120 ENOG4105CAQ asparagine synthetase FORC086_06125 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FORC086_06130 ENOG4105CH6 catalase FORC086_06135 ENOG4105BZU Histidine kinase FORC086_06155 ENOG4108VPT UPF0234 protein FORC086_06160 ENOG4105QNR S1 RNA binding domain protein FORC086_06165 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC086_06175 ENOG4107AYK membrAne FORC086_06180 ENOG41073B9 FORC086_06190 ENOG4108KP7 hydrolase FORC086_06205 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FORC086_06230 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FORC086_06235 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FORC086_06250 ENOG4105C31 Tryptophanyl-tRNA synthetase FORC086_06270 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FORC086_06275 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FORC086_06285 ENOG4108JQ7 (ABC) transporter FORC086_06290 ENOG4105UQX Mate efflux family protein FORC086_06315 ENOG4108ZCF integral membrane protein FORC086_06325 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FORC086_06335 ENOG4105DPN Oligoendopeptidase f FORC086_06350 ENOG4108Z18 K06886 hemoglobin FORC086_06355 ENOG4105MIX Adenylate cyclase FORC086_06360 ENOG4106EFP UPF0738 protein FORC086_06370 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FORC086_06375 ENOG4105EMS pseudouridine synthase FORC086_06395 ENOG4105K64 Glycosyl transferase, family 2 FORC086_06415 ENOG4107TVC Glycosyl transferase, family 2 FORC086_06435 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FORC086_06440 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FORC086_06450 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FORC086_06500 ENOG4108ZMI UPF0477 protein FORC086_06530 ENOG4105CK7 Sodium proline symporter FORC086_06540 ENOG4105CRQ synthase (Component I) FORC086_06545 ENOG4105DDQ anthranilate synthase FORC086_06565 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FORC086_06640 ENOG4105C7S Dehydrogenase FORC086_06645 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FORC086_06650 ENOG4105VZ8 Transcriptional regulator FORC086_06710 ENOG4105DZ1 carboxypeptidase FORC086_06715 ENOG4105VFR signal peptidase FORC086_06750 ENOG4105C26 Dehydrogenase FORC086_06755 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC086_06760 ENOG4105F38 ABC transporter, permease FORC086_06765 ENOG4105D38 putrescine abc transporter FORC086_06770 ENOG4107RUE extracellular solute-binding protein family 1 FORC086_06780 ENOG4105EYF MMPL domain protein FORC086_06790 ENOG4108YBP pseudouridine synthase FORC086_06800 ENOG4105K4I Scp-like extracellular FORC086_06805 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FORC086_06810 ENOG4105CQB FAD linked oxidase domain protein FORC086_06825 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC086_06830 ENOG4105BZU Histidine kinase FORC086_06835 ENOG4105JXH GntR family transcriptional regulator FORC086_06855 ENOG4106A3R peptidase FORC086_06865 ENOG4108QTI )-transporter FORC086_06870 ENOG4107TS3 membrane protein, TerC FORC086_06875 ENOG4105CZN Potassium uptake protein FORC086_06880 ENOG410681C small acid-soluble spore protein FORC086_06885 ENOG4108Z7G MaoC domain protein dehydratase FORC086_06905 ENOG4105CHR reductase FORC086_06945 ENOG4105C4Y ABC transporter FORC086_06950 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC086_06955 ENOG4107RCV ABC transporter, permease FORC086_06975 ENOG4105E98 transcriptional regulator DeoR family FORC086_06990 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FORC086_07000 ENOG4105PXI polysaccharide deacetylase FORC086_07010 ENOG4105BZU Histidine kinase FORC086_07015 ENOG41090MY MarR family Transcriptional regulator FORC086_07025 ENOG4106DF1 FORC086_07035 ENOG4105BZU Histidine kinase FORC086_07040 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FORC086_07045 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FORC086_07050 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FORC086_07095 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FORC086_07100 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FORC086_07105 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FORC086_07110 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FORC086_07115 ENOG4105CZV ABC transporter FORC086_07125 ENOG4105CJ1 ABC, transporter FORC086_07165 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FORC086_07170 ENOG4105EA8 2-Nitropropane dioxygenase FORC086_07175 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FORC086_07185 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FORC086_07210 ENOG4105NQC Flavodoxin FORC086_07255 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FORC086_07285 ENOG4105CZN Potassium uptake protein FORC086_07290 ENOG41063Y9 FORC086_07295 ENOG4105KBJ sporulation protein ytfj FORC086_07325 ENOG4105CM2 brancheD-chain amino acid aminotransferase FORC086_07330 ENOG4105C7K acetolactate synthase FORC086_07335 ENOG4108ZP8 Acetolactate synthase small subunit FORC086_07340 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FORC086_07355 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FORC086_07375 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FORC086_07380 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FORC086_07405 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase FORC086_07410 ENOG4107RVV histidinol phosphate phosphatase, hisj family FORC086_07425 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FORC086_07430 ENOG4105E0M Sulfatase FORC086_07440 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FORC086_07455 ENOG4107S4M Sulfate adenylate transferase FORC086_07460 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FORC086_07465 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FORC086_07475 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FORC086_07480 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FORC086_07485 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FORC086_07495 ENOG4105C8J )-transporter FORC086_07515 ENOG4105DFD Na H antiporter FORC086_07535 ENOG4105ENE Histidine kinase FORC086_07540 ENOG4105WH1 Two component transcriptional regulator luxr family FORC086_07560 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FORC086_07585 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FORC086_07610 ENOG4105CJ3 phosphate transporter FORC086_07615 ENOG4107GRR phosphate transport regulator FORC086_07620 ENOG4105BZ4 penicillin-binding protein FORC086_07635 ENOG4105BZU Histidine kinase FORC086_07640 ENOG4105I3N Conserved Protein FORC086_07655 ENOG4105BZU Histidine kinase FORC086_07690 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FORC086_07695 ENOG4105DZ1 carboxypeptidase FORC086_07700 ENOG4108JIC nucleoside recognition domain protein FORC086_07710 ENOG4105FE9 pseudouridine synthase FORC086_07715 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC086_07720 ENOG4107TWT Cytochrome c biogenesis protein FORC086_07725 ENOG4105CRE cytochrome C FORC086_07730 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC086_07735 ENOG4105BZU Histidine kinase FORC086_07740 ENOG4108WBT adenosyltransferase FORC086_07755 ENOG4108SAX Membrane FORC086_07770 ENOG4105C9U ATP-dependent DNA helicase RecQ FORC086_07775 ENOG4105I7S Abortive infection protein FORC086_07785 ENOG4107RGJ metallophosphoesterase FORC086_07790 ENOG4108XDN Transcriptional regulator FORC086_07795 ENOG4108S6Z Negative regulator of genetic competence FORC086_07820 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FORC086_07825 ENOG4107RB3 L-asparaginase FORC086_07845 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FORC086_07860 ENOG4105S2F FORC086_07865 ENOG41065D1 FORC086_07895 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FORC086_07910 ENOG4105XXQ heptaprenyl diphosphate synthase component I FORC086_07920 ENOG4105EAH synthase FORC086_07925 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FORC086_07930 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FORC086_07945 ENOG41068YB TPR repeat-containing protein FORC086_07960 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FORC086_07965 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FORC086_08000 ENOG4108JYZ YitT family FORC086_08010 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FORC086_08025 ENOG4105FJR Lmbe family FORC086_08030 ENOG4105CPK Glycosyl transferase (Group 1 FORC086_08055 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FORC086_08070 ENOG4105DVT helicase FORC086_08075 ENOG4105YAC FORC086_08095 ENOG4105CSM endonuclease III FORC086_08105 ENOG4105BZ4 penicillin-binding protein FORC086_08165 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FORC086_08205 ENOG4105DVT helicase FORC086_08210 ENOG4105CTD carboxy-peptidase FORC086_08220 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FORC086_08225 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) FORC086_08230 ENOG4105C2W permease FORC086_08235 ENOG4105DHF Membrane FORC086_08245 ENOG410890F Dynamin family FORC086_08255 ENOG4108W0I acetyltransferase FORC086_08265 ENOG4105KHC sulfurtransferase FORC086_08290 ENOG4106032 Glutathionylspermidine synthase FORC086_08320 ENOG4105HTX biosynthesis protein FORC086_08350 ENOG4105CPK Glycosyl transferase (Group 1 FORC086_08365 ENOG4108SZE gCN5-related N-acetyltransferase FORC086_08385 ENOG41081VK Ribonuclease FORC086_08450 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FORC086_08460 ENOG4107RWR Sodium hydrogen exchanger FORC086_08465 ENOG4105CN5 Metallo-Beta-Lactamase FORC086_08470 ENOG4108Z5V transcriptional regulator, merr family FORC086_08480 ENOG4105H67 Protein of unknown function (DUF421) FORC086_08485 ENOG41080C8 DUF218 domain FORC086_08520 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FORC086_08530 ENOG4107R0U MotA TolQ exbB proton channel FORC086_08535 ENOG4105ER2 Ompa motb domain protein FORC086_08540 ENOG4107YTP response regulator receiver protein FORC086_08545 ENOG4105CBS Chea signal transduction histidine kinase FORC086_08550 ENOG4105DD5 Flagellar motor switch protein FORC086_08565 ENOG4105BZU Histidine kinase FORC086_08585 ENOG4105E1Q flagellar hook-associated protein FORC086_08590 ENOG4105DTJ flagellar hook-associated protein FORC086_08610 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FORC086_08615 ENOG4108ZC9 flagellar basal-body rod protein flgc FORC086_08620 ENOG41075Z6 flagellar hook-basal body complex protein fliE FORC086_08625 ENOG4107U2N Flagellar M-ring protein FORC086_08630 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FORC086_08660 ENOG4105BZE flagellar hook protein, FlgE FORC086_08675 ENOG4107R88 Chemotaxis protein (CheV) FORC086_08685 ENOG4105I03 Flagellin FORC086_08690 ENOG4105I03 Flagellin FORC086_08695 ENOG4105E4C Lytic transglycosylase catalytic FORC086_08705 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FORC086_08710 ENOG4105DD5 Flagellar motor switch protein FORC086_08720 ENOG4105CN7 Flagellar biosynthetic protein FliP FORC086_08725 ENOG4105VS8 Flagellar biosynthetic protein fliq FORC086_08735 ENOG4105D00 flagellar biosynthetic protein flhB FORC086_08740 ENOG4105D7B Flagellar biosynthesis protein flha FORC086_08745 ENOG4105FZW flagellar biosynthesis regulator FlhF FORC086_08750 ENOG4105KTQ flagellar basal-body rod protein FORC086_08755 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FORC086_08790 ENOG4105KAC Antibiotic biosynthesis monooxygenase FORC086_08815 ENOG4105DUM transcriptional regulator, lysR family FORC086_08820 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FORC086_08830 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FORC086_08865 ENOG4105CVJ phosphoglycerate mutase FORC086_08875 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FORC086_08895 ENOG4105CAQ asparagine synthetase FORC086_08915 ENOG4105PGM cation diffusion facilitator family transporter FORC086_08925 ENOG4105DRR Transcriptional regulator, GntR family FORC086_08930 ENOG4108UZ3 Transporter FORC086_08940 ENOG4105CKI cobalamin synthesis protein FORC086_08945 ENOG4108PJD permease FORC086_08960 ENOG4105DFD Na H antiporter FORC086_08965 ENOG4105VUF Transcriptional regulator FORC086_08975 ENOG4105C9Q fumarate hydratase class II FORC086_08995 ENOG4107QJQ Mate efflux family protein FORC086_09000 ENOG4105EC3 peptidase S51, dipeptidase E FORC086_09020 ENOG4107QIV Cytochrome c biogenesis protein FORC086_09025 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC086_09045 ENOG4106BRA Membrane FORC086_09085 ENOG4105CJ1 ABC, transporter FORC086_09110 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FORC086_09120 ENOG4108IJ0 Aspartate ammonia-lyase FORC086_09125 ENOG4105C6K Malic enzyme FORC086_09160 ENOG41067QW Transcriptional regulator FORC086_09190 ENOG4105FVX FORC086_09195 ENOG4105E09 nadh pyrophosphatase FORC086_09210 ENOG4105CSR polyphosphate kinase 2 FORC086_09225 ENOG4105DXI Major Facilitator superfamily FORC086_09240 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FORC086_09245 ENOG4105EU0 Major facilitator Superfamily FORC086_09250 ENOG4105C6T cysteine synthase FORC086_09270 ENOG4105C8J )-transporter FORC086_09280 ENOG4105X5K response regulator receiver protein FORC086_09285 ENOG4105H67 Protein of unknown function (DUF421) FORC086_09320 ENOG4105CHR reductase FORC086_09325 ENOG4105CM2 brancheD-chain amino acid aminotransferase FORC086_09330 ENOG4105C7K acetolactate synthase FORC086_09340 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FORC086_09345 ENOG4105C01 Dihydroxy-acid dehydratase FORC086_09350 ENOG4105C7B Threonine dehydratase FORC086_09370 ENOG4105C6X Major Facilitator FORC086_09375 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FORC086_09385 ENOG4105DY9 regulatoR FORC086_09390 ENOG4105CYC Transferase FORC086_09415 ENOG41068WN FORC086_09435 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FORC086_09440 ENOG4105C72 UPF0176 protein FORC086_09450 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FORC086_09455 ENOG4105C0X amino acid FORC086_09495 ENOG410849A acetyltransferase, (GNAT) family FORC086_09520 ENOG4107RHR regulatoR FORC086_09530 ENOG4105D9N nucleoside FORC086_09535 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FORC086_09595 ENOG410811B TRANSCRIPTIONal FORC086_09610 ENOG4107RAQ aminopeptidase FORC086_09620 ENOG4107R16 Multicopper oxidase FORC086_09625 ENOG41061JJ Peptidase family M23 FORC086_09635 ENOG4105MKU Transcriptional regulator FORC086_09680 ENOG4105W8Z 4'-phosphopantetheinyl transferase FORC086_09730 ENOG4108T5E Copper resistance protein FORC086_09735 ENOG4105KTB nuclear export factor GLE1 FORC086_09740 ENOG4107RT3 EamA-like transporter family FORC086_09745 ENOG4105GZI Transcriptional regulator FORC086_09750 ENOG4108Z40 Transcriptional regulator FORC086_09755 ENOG4107ZXU DSBA oxidoreductase FORC086_09760 ENOG4108TVJ Nitroreductase FORC086_09770 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FORC086_09775 ENOG4106F5Q Membrane FORC086_09780 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FORC086_09795 ENOG4105CKI cobalamin synthesis protein FORC086_09805 ENOG4105C0Z ABC transporter FORC086_09810 ENOG4108IV0 ABC, transporter FORC086_09815 ENOG4105C32 Amino acid ABC transporter (Permease) FORC086_09825 ENOG4105SKE transcriptional Regulator LysR family FORC086_09855 ENOG4105C4M (Ubiquinol oxidase) subunit I FORC086_09860 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FORC086_09865 ENOG4108JJ9 ABC, transporter FORC086_09870 ENOG4108JJ8 (ABC) transporter FORC086_09880 ENOG4105K64 Glycosyl transferase, family 2 FORC086_09890 ENOG4108UT6 Transferase hexapeptide repeat containing protein FORC086_09945 ENOG4105BZ1 (ABC) transporter FORC086_09950 ENOG4105EFI regulatoR FORC086_09955 ENOG4105BZU Histidine kinase FORC086_09965 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FORC086_09970 ENOG4108ZJ4 polysaccharide deacetylase FORC086_09990 ENOG4105D6E homoserine dehydrogenase FORC086_10000 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FORC086_10015 ENOG4108KGH TRANSCRIPTIONal FORC086_10025 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC086_10030 ENOG4105BZU Histidine kinase FORC086_10035 ENOG4107VMI polysaccharide deacetylase FORC086_10045 ENOG4105KT7 mgtC SapB transporter FORC086_10050 ENOG4105VRR gCN5-related N-acetyltransferase FORC086_10060 ENOG4105DUU IucA IucC family protein FORC086_10065 ENOG4105CEY Amp-dependent synthetase and ligase FORC086_10080 ENOG4108WBH protein TIM barrel FORC086_10085 ENOG4105YWU small acid-soluble spore protein FORC086_10095 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FORC086_10100 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC086_10150 ENOG4105KRN Transcriptional regulator, abrb family FORC086_10160 ENOG4105YVS arsR family transcriptional regulator FORC086_10165 ENOG4107SET aldo keto reductase FORC086_10170 ENOG4107XZQ multidrug resistance protein FORC086_10180 ENOG4105KAF membrAne FORC086_10205 ENOG4105C8Q Methyl-accepting chemotaxis FORC086_10225 ENOG4108K88 Membrane FORC086_10230 ENOG4108WPJ Ferritin-like domain FORC086_10245 ENOG4105DEN Luciferase family FORC086_10260 ENOG4105VMI -acetyltransferase FORC086_10265 ENOG4107QM2 Aldo Keto reductase FORC086_10270 ENOG4105CKI cobalamin synthesis protein FORC086_10280 ENOG4105DSE periplasmic solute binding protein FORC086_10290 ENOG4105K4T epimerase FORC086_10300 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FORC086_10345 ENOG4107T5V SNARE associated Golgi FORC086_10360 ENOG4108PJD permease FORC086_10370 ENOG4108S4H thioesterase Superfamily protein FORC086_10380 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FORC086_10400 ENOG4105SXS Protein of unknown function (DUF456) FORC086_10405 ENOG4105C37 (CBS) domain FORC086_10425 ENOG4108Z7R Chaperone CsaA FORC086_10445 ENOG4108ZRV stage ii sporulation protein p FORC086_10455 ENOG4108VXD carboxy-peptidase FORC086_10465 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FORC086_10485 ENOG4108ZRV stage ii sporulation protein p FORC086_10495 ENOG4108X4Q Hydrolase FORC086_10510 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FORC086_10530 ENOG41087PP glycosyltransferase MGT family FORC086_10535 ENOG4108JYZ YitT family FORC086_10540 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC086_10570 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FORC086_10590 ENOG4106PAW secretion accessory protein EsaA YueB FORC086_10600 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) FORC086_10605 ENOG4108MGT Required for secretion of EsxA and EsxB FORC086_10690 ENOG4105KBJ sporulation protein ytfj FORC086_10715 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FORC086_10735 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) FORC086_10740 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FORC086_10750 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FORC086_10755 ENOG4105EMN RNA polymerase sigma factor FORC086_10770 ENOG4105CNW domain protein FORC086_10780 ENOG4108V06 Glutathione peroxidase FORC086_10795 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FORC086_10805 ENOG4108IUE nitrate reductase beta subunit FORC086_10810 ENOG4105R3A Nitrate reductase FORC086_10820 ENOG4107V6Q Cyclic nucleotide-binding domain FORC086_10825 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FORC086_10830 ENOG4105D06 uba thif-type nad fad binding protein FORC086_10835 ENOG4105CVM Molybdenum cofactor synthesis domain protein FORC086_10840 ENOG4108ZAF Molybdopterin FORC086_10875 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FORC086_10880 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FORC086_10885 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FORC086_10890 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FORC086_10895 ENOG4108IFG nitrite reductase, (NAD(P)H) FORC086_10900 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FORC086_10935 ENOG4105MCT stage V sporulation protein S FORC086_10985 ENOG4105C5H ABC transporter FORC086_11000 ENOG4108UUM single-stranded DNA-binding protein FORC086_11020 ENOG4107YX5 Pfam:DUF548 FORC086_11025 ENOG4105C75 arginyL-tRNA synthetase FORC086_11050 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FORC086_11080 ENOG4105C5S asparaginyl-tRNA synthetase FORC086_11085 ENOG4105C8J )-transporter FORC086_11105 ENOG4107XGZ Hydrolase FORC086_11110 ENOG4105CY2 Citrate transporter FORC086_11130 ENOG4105KD7 acetyltransferase FORC086_11140 ENOG4105VMP Transcriptional regulator FORC086_11145 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FORC086_11170 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FORC086_11185 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FORC086_11190 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FORC086_11200 ENOG4107RVG penicillin-binding protein FORC086_11205 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FORC086_11210 ENOG4105E9Q Acyl-transferase FORC086_11215 ENOG4108UT2 hemolysin iii FORC086_11225 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FORC086_11235 ENOG4108RCR degv family FORC086_11245 ENOG4108KF3 Electron transport protein SCO1 SenC FORC086_11250 ENOG4107Y70 Heat shock protein FORC086_11255 ENOG4105CAQ asparagine synthetase FORC086_11270 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FORC086_11275 ENOG4108MES Periplasmic binding protein FORC086_11280 ENOG4105F0I Aminotransferase FORC086_11315 ENOG4105D8X mechanosensitive ion channel FORC086_11320 ENOG4105BZU Histidine kinase FORC086_11325 ENOG4105WH1 Two component transcriptional regulator luxr family FORC086_11330 ENOG4106KNT transcriptional regulator FORC086_11335 ENOG4107ZY0 Phenazine biosynthesis-like protein FORC086_11355 ENOG4105CMG Carbohydrate kinase FORC086_11360 ENOG4105C6Z Gluconate FORC086_11370 ENOG4108YV3 Protein of unknown function (DUF2711) FORC086_11400 ENOG4108IJ8 ABC transporter FORC086_11405 ENOG4105E90 ABC transporter FORC086_11440 ENOG4105C37 (CBS) domain FORC086_11465 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FORC086_11480 ENOG4107S4Y M20 DapE family protein YgeY FORC086_11485 ENOG4108TSC N-acetyltransferase FORC086_11490 ENOG4108JUB Transcriptional regulator FORC086_11495 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FORC086_11540 ENOG410841Q phosphoesterase PA-phosphatase related protein FORC086_11550 ENOG4105SZ6 Thioredoxin FORC086_11600 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC086_11655 ENOG4105BZ4 penicillin-binding protein FORC086_11665 ENOG4105CZM Major Facilitator FORC086_11670 ENOG4105W8X HesB YadR YfhF-family protein FORC086_11680 ENOG4105DXD 2-methylcitrate dehydratase FORC086_11685 ENOG4105CR4 methylisocitrate lyase FORC086_11690 ENOG4105C1G acyl-Coa dehydrogenase FORC086_11695 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FORC086_11705 ENOG4105N14 lysine exporter protein LysE YggA FORC086_11710 ENOG4105E39 Enoyl-CoA hydratase FORC086_11725 ENOG4107RFY SbcCD D subunit FORC086_11730 ENOG4105EYH Exonuclease FORC086_11760 ENOG4105FCD Major Facilitator FORC086_11770 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FORC086_11775 ENOG4105E4F Isochorismate synthase FORC086_11780 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FORC086_11785 ENOG4105WQI isochorismatase FORC086_11790 ENOG4105CEY Amp-dependent synthetase and ligase FORC086_11795 ENOG4105WQT MbtH domain protein FORC086_11800 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC086_11815 ENOG4105K70 DNA-binding protein FORC086_11835 ENOG4105BZG amino acid carrier protein FORC086_11865 ENOG4105FE9 pseudouridine synthase FORC086_11870 ENOG4105C22 threonyL-tRNA synthetase FORC086_11875 ENOG4105C19 ABC transporter FORC086_11930 ENOG41081I9 integral membrane protein FORC086_11940 ENOG4108Y4K DNA-binding transcriptional activator FORC086_11955 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FORC086_11965 ENOG4105EYF MMPL domain protein FORC086_11985 ENOG4105WCN acetyltransferase FORC086_12010 ENOG4105C1Q protoporphyrinogen oxidase FORC086_12025 ENOG41068WN FORC086_12055 ENOG4107V2S Transcriptional regulator FORC086_12060 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FORC086_12080 ENOG4105DND Transcriptional regulator FORC086_12085 ENOG4108RPX mosc domain containing protein FORC086_12100 ENOG4105BZ1 (ABC) transporter FORC086_12105 ENOG4105BZ1 (ABC) transporter FORC086_12140 ENOG4108JCI Transcriptional regulator FORC086_12170 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) FORC086_12175 ENOG4108KPJ rna polymerase sigma factor FORC086_12205 ENOG4105F32 YngK protein FORC086_12225 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) FORC086_12230 ENOG4105RD7 BadF BadG BcrA BcrD FORC086_12235 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FORC086_12245 ENOG4105C7B Threonine dehydratase FORC086_12250 ENOG4108INS Transcriptional regulator FORC086_12265 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FORC086_12275 ENOG4105C1J atp-dependent rna helicase FORC086_12285 ENOG4108IG5 Transcriptional regulator FORC086_12305 ENOG41088CC tellurite resistance protein tehB FORC086_12315 ENOG4108I0C methyltransferase FORC086_12320 ENOG4107RA9 decarboxylase FORC086_12325 ENOG41090HR transcriptional regulator FORC086_12360 ENOG4105CIN aminoacyl-histidine dipeptidase FORC086_12390 ENOG4105KRN Transcriptional regulator, abrb family FORC086_12400 ENOG4105EJ9 Membrane FORC086_12405 ENOG4105EQK -acetyltransferase FORC086_12445 ENOG4105W8Z 4'-phosphopantetheinyl transferase FORC086_12550 ENOG4108IG5 Transcriptional regulator FORC086_12560 ENOG4105FQP Beta-lactamase FORC086_12565 ENOG4107RVG penicillin-binding protein FORC086_12580 ENOG4107RF6 penicillin-binding protein FORC086_12585 ENOG4107RF6 penicillin-binding protein FORC086_12595 ENOG4105DIN metallophosphoesterase FORC086_12605 ENOG4105CJ1 ABC, transporter FORC086_12615 ENOG4107Z3H Transcriptional regulator, TetR family FORC086_12630 ENOG4105C1G acyl-Coa dehydrogenase FORC086_12635 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FORC086_12640 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FORC086_12645 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FORC086_12650 ENOG4105E39 Enoyl-CoA hydratase FORC086_12655 ENOG4107QX3 carboxylase FORC086_12660 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FORC086_12680 ENOG4105DBI uridine monophosphokinase FORC086_12705 ENOG4105DZ1 carboxypeptidase FORC086_12720 ENOG4105T9C HD domain FORC086_12740 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FORC086_12760 ENOG41075H3 AraC family transcriptional regulator FORC086_12790 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FORC086_12800 ENOG4105CHR reductase FORC086_12805 ENOG4105KVH Transcriptional regulator FORC086_12825 ENOG4105MDS 4-oxalocrotonate tautomerase FORC086_12830 ENOG4107V2S Transcriptional regulator FORC086_12865 ENOG4105EFA 4-hydroxyphenylacetate FORC086_12880 ENOG4105CPQ Dehydrogenase FORC086_12890 ENOG410900G Protein of unknown function (DUF421) FORC086_12895 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FORC086_12905 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FORC086_12960 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FORC086_12995 ENOG4105D6E homoserine dehydrogenase FORC086_13005 ENOG4105CPF Cell wall formation (By similarity) FORC086_13010 ENOG4105ETU transcriptional activator (TenA FORC086_13110 ENOG410667J hydrolase FORC086_13120 ENOG4105BZU Histidine kinase FORC086_13125 ENOG4107RF6 penicillin-binding protein FORC086_13150 ENOG4108JJB ABC transporter FORC086_13165 ENOG4108HGU Histidine kinase FORC086_13240 ENOG4105CB2 alcohol dehydrogenase FORC086_13245 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FORC086_13250 ENOG4105CJN penicillin-binding protein FORC086_13300 ENOG4107Y80 Major Facilitator superfamily FORC086_13305 ENOG4108Z5V transcriptional regulator, merr family FORC086_13330 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FORC086_13355 ENOG4107Y9U Membrane FORC086_13400 ENOG4105FCD Major Facilitator FORC086_13410 ENOG4105E09 nadh pyrophosphatase FORC086_13415 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FORC086_13435 ENOG4108XI2 Domain of unknown function (DUF1963) FORC086_13465 ENOG4108NRW Phospholipase, patatin family FORC086_13470 ENOG4105KWG Pfam:DUF1696 FORC086_13480 ENOG4108YYS metal-dependent hydrolase (By similarity) FORC086_13495 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FORC086_13505 ENOG4105PKS Excinuclease abc c subunit domain protein FORC086_13545 ENOG4107VFR oxidoreductase FORC086_13580 ENOG4105U0R haloacid dehalogenase-like hydrolase FORC086_13585 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC086_13590 ENOG4105BZU Histidine kinase FORC086_13610 ENOG4107WD8 ABC transporter, permease FORC086_13625 ENOG4105DY8 decarboxylase FORC086_13640 ENOG4108IUM Glycogen debranching enzyme FORC086_13650 ENOG4105CGH 5'-nucleotidase FORC086_13665 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FORC086_13670 ENOG4105FDR Membrane FORC086_13675 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FORC086_13680 ENOG4105CIS alcohol dehydrogenase FORC086_13685 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FORC086_13730 ENOG4105MSI germination protein ypeb FORC086_13760 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) FORC086_13765 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FORC086_13770 ENOG4107Z3H Transcriptional regulator, TetR family FORC086_13805 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FORC086_13825 ENOG4105E98 transcriptional regulator DeoR family FORC086_13840 ENOG41062ES Transcriptional regulator FORC086_13860 ENOG4107QKR Dehydrogenase FORC086_13870 ENOG4107RUY (E1 component), alpha subunit FORC086_13880 ENOG4105E1F short-chain dehydrogenase reductase FORC086_13885 ENOG4105RHY Pfam:UPF0157 FORC086_13925 ENOG4107SQ8 Glycine betaine FORC086_13930 ENOG4108IJ7 Glycine betaine FORC086_13940 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FORC086_13955 ENOG4105E66 phosphoriboisomerase A FORC086_13960 ENOG41082BV acetyltransferase FORC086_13965 ENOG4108M1A Chitin-binding protein FORC086_13990 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FORC086_13995 ENOG4105MSB protein, conserved in bacteria FORC086_14015 ENOG4108Z7F N-acetyltransferase FORC086_14035 ENOG4105EEM helicase FORC086_14050 ENOG4105C9U ATP-dependent DNA helicase RecQ FORC086_14100 ENOG4108M1A Chitin-binding protein FORC086_14115 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FORC086_14125 ENOG4105BZG amino acid carrier protein FORC086_14130 ENOG4105C26 Dehydrogenase FORC086_14135 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FORC086_14140 ENOG4105CTU Proline racemase FORC086_14145 ENOG4105CTU Proline racemase FORC086_14150 ENOG41080HI glycine oxidase FORC086_14160 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FORC086_14195 ENOG4105DCI Phosphohydrolase FORC086_14200 ENOG4107T5V SNARE associated Golgi FORC086_14210 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FORC086_14230 ENOG4105DTQ mandelate racemase muconate lactonizing FORC086_14245 ENOG4107SET aldo keto reductase FORC086_14285 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FORC086_14290 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FORC086_14295 ENOG4105BZU Histidine kinase FORC086_14300 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC086_14320 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 FORC086_14335 ENOG4105DPN Oligoendopeptidase f FORC086_14340 ENOG4105EPR degv family FORC086_14405 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FORC086_14410 ENOG4106K7D Major facilitator family transporter FORC086_14430 ENOG4107BMA Transglycosylase associated protein FORC086_14445 ENOG41089UC methyltransferase, type 11 FORC086_14485 ENOG4105CHM Aminotransferase FORC086_14500 ENOG4108ZMI UPF0477 protein FORC086_14545 ENOG4105C02 permease FORC086_14560 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FORC086_14565 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FORC086_14570 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FORC086_14575 ENOG4105D7T ABC transporter FORC086_14610 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FORC086_14650 ENOG4107VC0 DNA alkylation repair enzyme FORC086_14655 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FORC086_14665 ENOG4107VMI polysaccharide deacetylase FORC086_14675 ENOG4108ZCF integral membrane protein FORC086_14680 ENOG4105E0M Sulfatase FORC086_14685 ENOG4105C5H ABC transporter FORC086_14690 ENOG4105EYF MMPL domain protein FORC086_14695 ENOG41082JN Transcriptional regulator FORC086_14715 ENOG4105CIH Imidazole acetol-phosphate transaminase FORC086_14720 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FORC086_14730 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FORC086_14775 ENOG41069ER domain protein FORC086_14785 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FORC086_14790 ENOG4105DNP FAD linked oxidase domain protein FORC086_14820 ENOG4105F5R ABC transporter FORC086_14825 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FORC086_14835 ENOG4105DKT Transcriptional regulator FORC086_14840 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) FORC086_14850 ENOG41061GT Aldolase FORC086_14865 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FORC086_14905 ENOG4105II7 pyrroline-5-carboxylate reductase FORC086_14915 ENOG4107258 Transcriptional regulator FORC086_14940 ENOG4105ECK Fatty Acid Desaturase FORC086_14950 ENOG4107RBI VanW family FORC086_14955 ENOG4105G6Z alkaline phosphatase FORC086_14965 ENOG4105VMP Transcriptional regulator FORC086_14985 ENOG41068WN FORC086_15015 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FORC086_15040 ENOG4105CKK Glycosyl transferase, family 2 FORC086_15070 ENOG4105C8Y Acetylornithine aminotransferase FORC086_15120 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FORC086_15145 ENOG4108IBT Inherit from COG: transposase FORC086_15165 ENOG4108TVJ Nitroreductase FORC086_15170 ENOG4105FS7 Transcriptional regulator FORC086_15190 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FORC086_15195 ENOG4105WEC Molybdate metabolism regulator FORC086_15200 ENOG4105CMR udp-glucose 4-epimerase FORC086_15215 ENOG4108DMH HTH_ARAC FORC086_15220 ENOG4108XET gCN5-related N-acetyltransferase FORC086_15235 ENOG4108PCN EamA-like transporter family FORC086_15255 ENOG4107XJU UPF0178 protein FORC086_15290 ENOG410635A Membrane FORC086_15300 ENOG4108IQI permease FORC086_15310 ENOG4105F1N DNA alkylation repair FORC086_15360 ENOG4107RF6 penicillin-binding protein FORC086_15365 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FORC086_15385 ENOG4105E7W lamb ycsf family protein FORC086_15395 ENOG4105P4J Allophanate hydrolase, subunit 1 FORC086_15400 ENOG4107258 Transcriptional regulator FORC086_15410 ENOG4106N3A copper homeostasis protein cutc FORC086_15415 ENOG4108ZHR arsR family transcriptional regulator FORC086_15425 ENOG4105FDT acyl-CoA dehydrogenase FORC086_15440 ENOG4105DWD nucleoside recognition domain protein FORC086_15485 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FORC086_15510 ENOG4105E2A Dehydrogenase FORC086_15515 ENOG4108IJ0 Aspartate ammonia-lyase FORC086_15520 ENOG4105HDK L-asparaginase FORC086_15525 ENOG4108IMY Transcriptional regulator FORC086_15550 ENOG4108B31 Spore germination protein FORC086_15560 ENOG4105BZU Histidine kinase FORC086_15585 ENOG41075H3 AraC family transcriptional regulator FORC086_15605 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FORC086_15610 ENOG4105CUB amino acid FORC086_15615 ENOG4105II7 pyrroline-5-carboxylate reductase FORC086_15625 ENOG4105C6K Malic enzyme FORC086_15635 ENOG4108NHD germination protein FORC086_15640 ENOG4108Q8B Spore germination protein FORC086_15665 ENOG4105CSV Glutaminase FORC086_15700 ENOG4105CGH 5'-nucleotidase FORC086_15710 ENOG4105CHJ isochorismatase hydrolase FORC086_15735 ENOG41090MY MarR family Transcriptional regulator FORC086_15775 ENOG4105F6J Alpha beta hydrolase fold FORC086_15790 ENOG4108606 TspO/MBR family FORC086_15795 ENOG4105CVP deoxyribo-dipyrimidine photolyase FORC086_15815 ENOG4105F2M alpha beta hydrolase fold-3 domain protein FORC086_15830 ENOG4108TWJ NADH dehydrogenase subunit 5 FORC086_15835 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FORC086_15840 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC086_15850 ENOG4105F27 Major Facilitator FORC086_15855 ENOG4106P55 Transcriptional regulator FORC086_15865 ENOG4107VMI polysaccharide deacetylase FORC086_15870 ENOG4105KY5 gCN5-related N-acetyltransferase FORC086_15875 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FORC086_15885 ENOG4105D6J arsenicaL-resistance protein FORC086_15890 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FORC086_15895 ENOG41085FC arsR family transcriptional regulator FORC086_15905 ENOG4107P5I polyketide synthase FORC086_15910 ENOG4108IG5 Transcriptional regulator FORC086_15945 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC086_15950 ENOG41062D9 Histidine kinase FORC086_15990 ENOG4105DNP FAD linked oxidase domain protein FORC086_16005 ENOG4105C19 ABC transporter FORC086_16040 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FORC086_16045 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC086_16065 ENOG4105K6H D-cysteine desulfhydrase FORC086_16090 ENOG4108NNI Beta-lactamase domain-containing protein FORC086_16095 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FORC086_16105 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FORC086_16110 ENOG4105JQZ Methyltransferase FORC086_16130 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FORC086_16150 ENOG4105BZU Histidine kinase FORC086_16165 ENOG4108U05 Transcriptional regulator FORC086_16170 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 FORC086_16180 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FORC086_16215 ENOG4108JQ1 Dehydrogenase FORC086_16220 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FORC086_16260 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FORC086_16435 ENOG4106YAD MORN repeat variant FORC086_16525 ENOG4108VXD carboxy-peptidase FORC086_16530 ENOG4105PNM synthesis protein FORC086_16540 ENOG4108ISG Major Facilitator FORC086_16555 ENOG4107MII Sugar-specific transcriptional regulator TrmB FORC086_16560 ENOG4105CZM Major Facilitator FORC086_16585 ENOG4105DYS nad(p)h dehydrogenase (quinone) FORC086_16645 ENOG4108K8S endonuclease I FORC086_16665 ENOG4108Z66 YbaK ebsC protein FORC086_16670 ENOG4105CUT histidyl-tRNA synthetase FORC086_16685 ENOG4105KVH Transcriptional regulator FORC086_16690 ENOG4108RCM Nitroreductase FORC086_16725 ENOG4108PSK reductase FORC086_16790 ENOG4105C31 Tryptophanyl-tRNA synthetase FORC086_16795 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FORC086_16830 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) FORC086_16870 ENOG4105C37 (CBS) domain FORC086_16885 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FORC086_16890 ENOG4105FAW cDP-glucose 4,6-dehydratase FORC086_16920 ENOG4105DDN Pentapeptide repeat-containing protein FORC086_16925 ENOG4105XDF Protein of unknown function (DUF1272) FORC086_16930 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FORC086_16935 ENOG4105CMG Carbohydrate kinase FORC086_16940 ENOG4105C6Z Gluconate FORC086_16945 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FORC086_16960 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FORC086_17000 ENOG4105C44 Serine transporter FORC086_17030 ENOG4108TZY GntR Family Transcriptional Regulator FORC086_17035 ENOG4105D9R oxidoreductase FORC086_17080 ENOG4105JAB phenazine biosynthesis protein, phzf family FORC086_17090 ENOG4105CHR reductase FORC086_17100 ENOG4105KNA -acetyltransferase FORC086_17110 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FORC086_17115 ENOG4105KVH Transcriptional regulator FORC086_17135 ENOG4108ZJ4 polysaccharide deacetylase FORC086_17215 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FORC086_17230 ENOG4107YXZ hydrolase, family 25 FORC086_17265 ENOG4105H3G oxidoreductase FORC086_17345 ENOG4108TN2 lmbE family FORC086_17355 ENOG4107R3E Citrate transporter FORC086_17365 ENOG4105WCN acetyltransferase FORC086_17370 ENOG4108MES Periplasmic binding protein FORC086_17375 ENOG4105EHG Permease protein FORC086_17380 ENOG4105DQ5 transport system permease protein FORC086_17385 ENOG4105NX3 Membrane FORC086_17405 ENOG41068WN FORC086_17410 ENOG4107CUJ Protein of unknown function (DUF2690) FORC086_17420 ENOG4107V2S Transcriptional regulator FORC086_17450 ENOG4105C98 muts2 protein FORC086_17455 ENOG4105E5K Alpha-amylase FORC086_17460 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FORC086_17465 ENOG4105DPN Oligoendopeptidase f FORC086_17500 ENOG4108A04 Beta-lactamase FORC086_17525 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FORC086_17535 ENOG41082BM Transcriptional regulator, arsr family FORC086_17540 ENOG4105CIS alcohol dehydrogenase FORC086_17570 ENOG4105CQB FAD linked oxidase domain protein FORC086_17595 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FORC086_17610 ENOG4107TPS domain protein FORC086_17615 ENOG4105CEP NADH dehydrogenase FORC086_17625 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C FORC086_17630 ENOG4108M1A Chitin-binding protein FORC086_17640 ENOG4105E1K spore germination protein FORC086_17660 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FORC086_17670 ENOG4108IAJ Nad-dependent epimerase dehydratase FORC086_17675 ENOG4105FAW cDP-glucose 4,6-dehydratase FORC086_17740 ENOG4105BZU Histidine kinase FORC086_17745 ENOG4105C5H ABC transporter FORC086_17755 ENOG4107DUR UPF0457 protein FORC086_17775 ENOG4105BZU Histidine kinase FORC086_17785 ENOG4105KT7 mgtC SapB transporter FORC086_17795 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FORC086_17800 ENOG41073R8 VanW family FORC086_17810 ENOG4108R1P FORC086_17830 ENOG4105VEQ Cold shock protein FORC086_17850 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FORC086_17870 ENOG410904N short-chain dehydrogenase reductase FORC086_17880 ENOG4106IQC argininosuccinate lyase FORC086_17895 ENOG4108IA2 Sodium pantothenate symporter FORC086_17905 ENOG4105C26 Dehydrogenase FORC086_17910 ENOG4105CHR reductase FORC086_17920 ENOG4105EWU Squalene--hopene cyclase FORC086_17930 ENOG4105FR1 rard protein FORC086_17935 ENOG410696E Membrane FORC086_17955 ENOG4105D1F ATP-binding protein FORC086_17965 ENOG4108ZAF Molybdopterin FORC086_17970 ENOG4105CVM Molybdenum cofactor synthesis domain protein FORC086_17975 ENOG4105D06 uba thif-type nad fad binding protein FORC086_17980 ENOG4105TMB Formate nitrite transporter FORC086_17995 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FORC086_18000 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FORC086_18010 ENOG4108JB9 formate dehydrogenase FORC086_18020 ENOG4105E1K spore germination protein FORC086_18035 ENOG4105CUB amino acid FORC086_18090 ENOG4107QJT sodium dicarboxylate symporter FORC086_18095 ENOG4108KGH TRANSCRIPTIONal FORC086_18105 ENOG4105EMN RNA polymerase sigma factor FORC086_18115 ENOG4105CIG ABC transporter FORC086_18125 ENOG4105D9R oxidoreductase FORC086_18135 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FORC086_18145 ENOG4105K4P CoA-binding domain protein FORC086_18150 ENOG4105C0H protease FORC086_18155 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC086_18165 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FORC086_18170 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FORC086_18175 ENOG4105W8X HesB YadR YfhF-family protein FORC086_18205 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FORC086_18210 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FORC086_18225 ENOG4105BZ1 (ABC) transporter FORC086_18230 ENOG4108I0Z Aconitate hydratase FORC086_18260 ENOG4105E5W Transporter FORC086_18270 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FORC086_18290 ENOG4107F3J Amp-dependent synthetase and ligase FORC086_18295 ENOG4107ZYJ bioY protein FORC086_18300 ENOG4105CEY Amp-dependent synthetase and ligase FORC086_18345 ENOG4107AYK membrAne FORC086_18360 ENOG4105BZU Histidine kinase FORC086_18365 ENOG4105FBA Phospholipase Carboxylesterase FORC086_18370 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FORC086_18375 ENOG4105CK7 Sodium proline symporter FORC086_18385 ENOG4105CBC glutamate synthase FORC086_18390 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FORC086_18395 ENOG4108VJ1 Transcriptional regulator (CarD family FORC086_18400 ENOG4108903 Formimidoylglutamase FORC086_18460 ENOG4107QIV Cytochrome c biogenesis protein FORC086_18475 ENOG4105CH2 amidohydrolase FORC086_18485 ENOG4105CJ1 ABC, transporter FORC086_18500 ENOG4107RSM transcriptional regulator FORC086_18505 ENOG4105VAW lrga family FORC086_18510 ENOG41067MG lrgb family FORC086_18550 ENOG4105BZ1 (ABC) transporter FORC086_18555 ENOG4105BZ1 (ABC) transporter FORC086_18590 ENOG4108HW3 (ABC) transporter FORC086_18595 ENOG4105CGH 5'-nucleotidase FORC086_18605 ENOG4108SVB resolvase FORC086_18625 ENOG4105K7K Transcriptional regulator FORC086_18635 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FORC086_18640 ENOG4105DR5 peptidase FORC086_18645 ENOG41065S2 pneumococcal vaccine antigen FORC086_18675 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FORC086_18680 ENOG4105C5F glutamine synthetase FORC086_18685 ENOG4105KV4 Transcriptional regulator FORC086_18690 ENOG4105CXI aluminum resistance protein FORC086_18695 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FORC086_18700 ENOG4105EN6 Membrane FORC086_18705 ENOG4106F1P AAA ATPase, central domain protein FORC086_18735 ENOG41069ER domain protein FORC086_18745 ENOG4105DM4 PTS System FORC086_18750 ENOG4105DE4 1-phosphofructokinase FORC086_18755 ENOG4105E98 transcriptional regulator DeoR family FORC086_18760 ENOG4107QW4 alcohol dehydrogenase FORC086_18765 ENOG4108SJC Membrane FORC086_18780 ENOG4105C85 amino acid FORC086_18800 ENOG4105TMB Formate nitrite transporter FORC086_18805 ENOG4105K70 DNA-binding protein FORC086_18820 ENOG410681U heavy metal transport detoxification protein FORC086_18825 ENOG4105VPX protein, conserved in bacteria FORC086_18835 ENOG4105NIV Esterase FORC086_18840 ENOG4105E0A ABC, transporter FORC086_18875 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FORC086_18880 ENOG4105D03 DNA-3-methyladenine glycosylase II FORC086_18910 ENOG4105BZU Histidine kinase FORC086_18950 ENOG41067MG lrgb family FORC086_18970 ENOG4108S3Y transcriptional regulator FORC086_18975 ENOG4105CS2 ec 3.2.1.21 FORC086_18990 ENOG4105F0V Cell wall hydrolase FORC086_19005 ENOG4105E0M Sulfatase FORC086_19010 ENOG410890F Dynamin family FORC086_19045 ENOG4105DQU oxidoreductase, subunit beta FORC086_19050 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FORC086_19055 ENOG4108IGT Dipeptidase FORC086_19060 ENOG4105MCT stage V sporulation protein S FORC086_19065 ENOG4105D48 metallophosphoesterase FORC086_19085 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FORC086_19100 ENOG4105XZV Protein of unknown function (DUF3243) FORC086_19105 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FORC086_19125 ENOG4105UIB (ABC) transporter FORC086_19130 ENOG4108JQ9 ABC transporter FORC086_19135 ENOG4105DIH basic membrane FORC086_19140 ENOG4105FDP GntR family transcriptional regulator FORC086_19150 ENOG4105CNU cell division protein FtsK FORC086_19160 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FORC086_19170 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FORC086_19180 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FORC086_19185 ENOG4108S0H Dipicolinic acid synthetase, b subunit FORC086_19190 ENOG4105E35 Dipicolinate synthase subunit A FORC086_19200 ENOG4105C1V Peptidase, M16 FORC086_19220 ENOG4105DTN riboflavin biosynthesis protein ribF FORC086_19235 ENOG4105W7A Protein of unknown function (DUF503) FORC086_19245 ENOG4105VHM ribosomal protein FORC086_19250 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FORC086_19255 ENOG4105CHV Transcription elongation factor NusA FORC086_19265 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FORC086_19280 ENOG4105DZP Membrane-associated zinc metalloprotease FORC086_19285 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FORC086_19290 ENOG4105KNE Phosphatidate cytidylyltransferase FORC086_19295 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FORC086_19305 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FORC086_19335 ENOG4108HE4 integrase family FORC086_19345 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FORC086_19350 ENOG4105C79 DNA protecting protein DprA FORC086_19355 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FORC086_19370 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FORC086_19395 ENOG4105VB6 UPF0109 protein FORC086_19415 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FORC086_19420 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FORC086_19435 ENOG4105CHR reductase FORC086_19440 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FORC086_19455 ENOG4105CB5 ATP-dependent DNA helicase recG FORC086_19460 ENOG4105DP4 dak2 domain fusion protein ylov FORC086_19465 ENOG4108ZAA Alkaline-shock protein FORC086_19480 ENOG4105FJ0 thiamine FORC086_19485 ENOG4105DJV ribulose-phosphate 3-epimerase FORC086_19490 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FORC086_19495 ENOG4105D9P serine threonine protein kinase FORC086_19500 ENOG4108ZF3 Phosphatase FORC086_19510 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FORC086_19525 ENOG4105C25 Primosomal protein n' FORC086_19530 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FORC086_19550 ENOG4105DSJ YicC domain protein FORC086_19560 ENOG4105F23 Fibronectin-binding protein FORC086_19565 ENOG4105DC7 peptidase M24 FORC086_19590 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FORC086_19605 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) FORC086_19610 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FORC086_19615 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FORC086_19620 ENOG4105CD3 dihydroorotase FORC086_19640 ENOG4105C34 Pseudouridine synthase FORC086_19655 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FORC086_19665 ENOG4105DBK s4 domain protein FORC086_19670 ENOG41067XK integral membrane protein FORC086_19680 ENOG4105DFA alanine racemase domain protein FORC086_19685 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FORC086_19690 ENOG4105WR5 sporulation protein, YlmC YmxH family FORC086_19700 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC086_19710 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FORC086_19715 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FORC086_19725 ENOG4105D4A Cell wall formation (By similarity) FORC086_19730 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FORC086_19735 ENOG4105CNI cell division protein FtsW FORC086_19750 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FORC086_19755 ENOG4105CJN penicillin-binding protein FORC086_19760 ENOG4105CJN penicillin-binding protein FORC086_19775 ENOG41074B2 UPF0747 protein FORC086_19800 ENOG4105KNH Nucleic acid-binding protein FORC086_19810 ENOG41063PX domain protein FORC086_19815 ENOG4105D78 K07001 NTE family protein FORC086_19820 ENOG4105H20 Sporulation integral membrane protein YlbJ FORC086_19830 ENOG4106H78 methyltransferase FORC086_19850 ENOG4107TB6 phosphoglycerate mutase FORC086_19865 ENOG4106UY4 Inherit from COG: Scp-like extracellular FORC086_19915 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FORC086_19925 ENOG4105CNI cell division protein FtsW FORC086_19940 ENOG4108IAB Phoh family FORC086_19960 ENOG4105QA2 FORC086_19965 ENOG4105CI3 gtp-binding protein typa FORC086_19975 ENOG4105ECY inositol monophosphatase FORC086_19995 ENOG4105CXN decarboxylase FORC086_20045 ENOG4105CPP Dehydrogenase, E1 component FORC086_20060 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FORC086_20065 ENOG4108X4Q Hydrolase FORC086_20080 ENOG4105CN5 Metallo-Beta-Lactamase FORC086_20085 ENOG4107ZYR domain protein FORC086_20120 ENOG4108XRC Protein of unknown function (DUF458) FORC086_20130 ENOG4107IN1 Protein of unknown function (DUF1797) FORC086_20145 ENOG4105EPM Diguanylate phosphodiesterase FORC086_20150 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FORC086_20165 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FORC086_20175 ENOG4105UIN FORC086_20240 ENOG4108HGU Histidine kinase FORC086_20250 ENOG4105CHM Aminotransferase FORC086_20255 ENOG4105FKQ transcriptional regulator FORC086_20260 ENOG4105EG2 ABC transporter, permease FORC086_20270 ENOG4107FKK extracellular solute-binding protein family 1 FORC086_20280 ENOG4105CG3 alpha amylase, catalytic region FORC086_20325 ENOG4105CHU acetyl-coa acetyltransferase FORC086_20360 ENOG4105K7K Transcriptional regulator FORC086_20365 ENOG4105DTD Dehydrogenase FORC086_20385 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FORC086_20410 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FORC086_20425 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FORC086_20435 ENOG4105BZU Histidine kinase FORC086_20455 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FORC086_20470 ENOG4105CID antiterminator FORC086_20480 ENOG4105FDP GntR family transcriptional regulator FORC086_20490 ENOG4105CE4 GlcNAc 6-P deacetylase FORC086_20530 ENOG4107ZE5 PPIases accelerate the folding of proteins FORC086_20535 ENOG4105PTM secreted protein FORC086_20540 ENOG4105J7I hydrolase FORC086_20550 ENOG4105G6R Stage v sporulation protein ae FORC086_20560 ENOG4105CZ3 stage V sporulation protein ad FORC086_20565 ENOG41090VF Stage v sporulation protein ac FORC086_20585 ENOG4105C8J )-transporter FORC086_20590 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC086_20600 ENOG41082AN stage II sporulation protein FORC086_20605 ENOG4105DZ1 carboxypeptidase FORC086_20615 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FORC086_20620 ENOG4105DVE abc transporter atp-binding protein FORC086_20655 ENOG4105D7N magnesium and cobalt transport protein CorA FORC086_20680 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FORC086_20690 ENOG4105I3K Ferric uptake regulator, Fur family FORC086_20695 ENOG4105MZ9 stage II sporulation protein m FORC086_20715 ENOG4105CPC Aldo Keto reductase FORC086_20725 ENOG4105RHY Pfam:UPF0157 FORC086_20745 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FORC086_20755 ENOG4105ETE Transcriptional regulator (LacI family FORC086_20760 ENOG4108YM7 Gcn5-related n-acetyltransferase FORC086_20780 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FORC086_20785 ENOG4108R6K riboflavin synthase, subunit alpha FORC086_20810 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FORC086_20815 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FORC086_20825 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FORC086_20830 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FORC086_20845 ENOG4105DFD Na H antiporter FORC086_20850 ENOG4105CGH 5'-nucleotidase FORC086_20875 ENOG4105DBV ornithine carbamoyltransferase FORC086_20890 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FORC086_20905 ENOG4108IXY short-chain dehydrogenase reductase FORC086_20910 ENOG41069FQ Metallo-beta-lactamase superfamily FORC086_20915 ENOG4105II7 pyrroline-5-carboxylate reductase FORC086_20920 ENOG4105EJQ L-serine dehydratase FORC086_20950 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FORC086_20965 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FORC086_20970 ENOG4105D9U N-acetyltransferase FORC086_20985 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FORC086_20990 ENOG4108QEG Membrane FORC086_20995 ENOG4105CDA abc transporter atp-binding protein FORC086_21000 ENOG4105E5Q amino acid AbC transporter FORC086_21005 ENOG4108HW3 (ABC) transporter FORC086_21015 ENOG4105G7B Protein of unknown function (DUF2992) FORC086_21020 ENOG4105E09 nadh pyrophosphatase FORC086_21025 ENOG4108QY0 Membrane FORC086_21040 ENOG4105C7S Dehydrogenase FORC086_21045 ENOG4105CPP Dehydrogenase, E1 component FORC086_21060 ENOG4105CKM Branched-chain carboxylic acid kinase FORC086_21065 ENOG4107RDP Dehydrogenase FORC086_21080 ENOG4108JUB Transcriptional regulator FORC086_21090 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FORC086_21105 ENOG4107QQR Sporulation FORC086_21115 ENOG4105S1Z Stage IV sporulation protein B FORC086_21120 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FORC086_21125 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FORC086_21130 ENOG4105DX0 Hemolysin A FORC086_21140 ENOG4105CTB Polyprenyl synthetase FORC086_21155 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FORC086_21165 ENOG4108ZSR alkaline shock protein FORC086_21170 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FORC086_21195 ENOG410644B Stage III sporulation protein af FORC086_21205 ENOG4105KQ4 Stage iii sporulation protein ad FORC086_21210 ENOG4108CQH stage III sporulation protein AC FORC086_21215 ENOG4105KR5 Stage iii sporulation protein FORC086_21220 ENOG4105CD2 stage iii sporulation protein aa FORC086_21245 ENOG4105DC7 peptidase M24 FORC086_21250 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FORC086_21260 ENOG4105CBJ Metal-dependent enzyme FORC086_21270 ENOG4107YBY Hydrolase FORC086_21285 ENOG4105K7K Transcriptional regulator FORC086_21300 ENOG41082GG biotin lipoate A B protein ligase FORC086_21305 ENOG4105WZW rhodanese family FORC086_21330 ENOG41080TC multidrug resistance protein FORC086_21375 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FORC086_21390 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FORC086_21410 ENOG4105C0D helicase FORC086_21535 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FORC086_21540 ENOG4105C3R Methionine synthase FORC086_21550 ENOG4105C28 cystathionine FORC086_21555 ENOG4105C28 cystathionine FORC086_21575 ENOG4105C5X domain protein FORC086_21585 ENOG4105DKQ ROK family FORC086_21595 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FORC086_21610 ENOG4108UTW Plays a role in the regulation of phosphate uptake FORC086_21615 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FORC086_21620 ENOG4105C8U phosphate abc transporter FORC086_21625 ENOG4105C8U phosphate abc transporter FORC086_21630 ENOG4105EXS phosphate abc transporter FORC086_21635 ENOG4107RF6 penicillin-binding protein FORC086_21645 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FORC086_21670 ENOG4105N80 Ferric uptake regulator, Fur family FORC086_21680 ENOG4105FDK ABC transporter FORC086_21685 ENOG4108JYZ YitT family FORC086_21690 ENOG41069ZM Protein of unknown function (DUF2624) FORC086_21715 ENOG4105EGD dinuclear metal center protein, YbgI family FORC086_21730 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC086_21735 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FORC086_21770 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FORC086_21775 ENOG4105KG3 cytidine deaminase FORC086_21780 ENOG4107YR5 Diacylglycerol kinase FORC086_21785 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FORC086_21790 ENOG4105CTJ Metal Dependent Phosphohydrolase FORC086_21795 ENOG4105C9A Phoh family FORC086_21805 ENOG41068P3 sporulation protein YqfC FORC086_21815 ENOG4105KTH gatB Yqey FORC086_21830 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FORC086_21835 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FORC086_21865 ENOG4105CSA Coproporphyrinogen iii oxidase FORC086_21870 ENOG4105KVH Transcriptional regulator FORC086_21895 ENOG4105TQK DNA polymerase iii, delta' subunit FORC086_21905 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FORC086_21910 ENOG4108UK2 deaminase FORC086_21915 ENOG4105KQC Competence protein FORC086_21925 ENOG4105DXX methyltransferase FORC086_21935 ENOG4108WF2 Metal Dependent Phosphohydrolase FORC086_21945 ENOG410812S Rna-binding protein FORC086_21955 ENOG4105CQW ribosome biogenesis GTPase YqeH FORC086_21960 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FORC086_21975 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC086_21995 ENOG4108TVJ Nitroreductase FORC086_22010 ENOG4105G6Z alkaline phosphatase FORC086_22015 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FORC086_22020 ENOG4108MUZ hydrolase FORC086_22055 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FORC086_22060 ENOG4105MIR Phenylalanine 4-monooxygenase FORC086_22070 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FORC086_22110 ENOG4105S6R Iron-hydroxamate transporter permease subunit FORC086_22115 ENOG4108V5C ABC transporter FORC086_22130 ENOG4108EKI Dehydrogenase FORC086_22135 ENOG4105C28 cystathionine FORC086_22165 ENOG4107XRG penicillin-binding protein FORC086_22175 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FORC086_22185 ENOG4105CFP Peptidase U32 FORC086_22190 ENOG4105XYU peptidase (U32 family) FORC086_22195 ENOG4108VQJ O-methyltransferase FORC086_22200 ENOG4105HHA aminodeoxychorismate lyase FORC086_22220 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FORC086_22230 ENOG4105C02 permease FORC086_22245 ENOG41060CR FORC086_22250 ENOG4105C7H Helicase, RecD TraA family FORC086_22260 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FORC086_22265 ENOG4105C3J Cysteine desulfurase FORC086_22275 ENOG4105D1H recombination factor protein RarA FORC086_22280 ENOG4108VCI transcription factor, rsfa family FORC086_22290 ENOG4105CUZ uba thif-type nad fad binding protein FORC086_22300 ENOG4105CUT histidyl-tRNA synthetase FORC086_22315 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FORC086_22325 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FORC086_22330 ENOG41076HS cation diffusion facilitator family transporter FORC086_22335 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FORC086_22345 ENOG4105CKP Polysaccharide Biosynthesis Protein FORC086_22350 ENOG4108QG2 Membrane FORC086_22360 ENOG4105VIE preprotein translocase, subunit YajC FORC086_22375 ENOG41061AI Protein of unknown function (DUF2905) FORC086_22390 ENOG4108HUF Transporter FORC086_22420 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FORC086_22425 ENOG4108IYU L-aspartate oxidase FORC086_22440 ENOG4108RPX mosc domain containing protein FORC086_22445 ENOG4105CQC Prephenate dehydratase FORC086_22460 ENOG4105C19 ABC transporter FORC086_22465 ENOG4105EWM Histidine kinase FORC086_22475 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FORC086_22490 ENOG4105X36 (ribosomal) protein FORC086_22500 ENOG4105C03 ribonuclease FORC086_22515 ENOG4107QMS site-determining protein FORC086_22530 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FORC086_22535 ENOG4105DFF Rod shape-determining protein mreb FORC086_22555 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FORC086_22560 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FORC086_22570 ENOG41068KH stage VI sporulation protein D FORC086_22580 ENOG4105D52 delta-aminolevulinic acid dehydratase FORC086_22605 ENOG4105K56 Transcriptional regulator FORC086_22625 ENOG4108IUQ atp-dependent protease FORC086_22655 ENOG4108QCI YvbH-like oligomerisation region FORC086_22680 ENOG4105M59 Phosphodiesterase, mj0936 family FORC086_22685 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FORC086_22695 ENOG4108XJQ germination protein FORC086_22705 ENOG4108PCX Major Facilitator FORC086_22720 ENOG4105KBX Transcriptional regulator, TetR family FORC086_22730 ENOG4105PFC Transcriptional regulator FORC086_22740 ENOG4105DZC cytosine deaminase FORC086_22745 ENOG41067S9 phage shock protein C, PspC FORC086_22750 ENOG4108JCI Transcriptional regulator FORC086_22760 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FORC086_22765 ENOG4108Z40 Transcriptional regulator FORC086_22770 ENOG4105RHA ABC transporter, permease FORC086_22775 ENOG4108IUX (ABC) transporter FORC086_22780 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FORC086_22785 ENOG4105ER2 Ompa motb domain protein FORC086_22790 ENOG4105E14 MotA TolQ exbB proton channel FORC086_22800 ENOG4108VXD carboxy-peptidase FORC086_22810 ENOG4105E33 succinate dehydrogenase FORC086_22820 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FORC086_22830 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FORC086_22835 ENOG4105K63 Thioredoxin FORC086_22840 ENOG4105C10 Electron transfer flavoprotein FORC086_22845 ENOG4105BZJ Electron transfer flavoprotein FORC086_22850 ENOG41060WC Enoyl-CoA hydratase FORC086_22855 ENOG4107Z3H Transcriptional regulator, TetR family FORC086_22860 ENOG4105CEY Amp-dependent synthetase and ligase FORC086_22870 ENOG4105J76 Periplasmic binding protein FORC086_22875 ENOG4105S6R Iron-hydroxamate transporter permease subunit FORC086_22925 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC086_22940 ENOG4105DR4 Methyltransferase FORC086_22950 ENOG4105KFN sortase, SrtB family FORC086_22955 ENOG4105E0A ABC, transporter FORC086_22970 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FORC086_22980 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FORC086_22990 ENOG4105FE9 pseudouridine synthase FORC086_23005 ENOG4105DCG PHP domain protein FORC086_23020 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FORC086_23050 ENOG4105C5S asparaginyl-tRNA synthetase FORC086_23055 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FORC086_23065 ENOG4108RWN rrna methyltransferase FORC086_23085 ENOG4105C0R drug resistance transporter emrb qaca subfamily FORC086_23090 ENOG4105CW7 secretion protein, HlyD family FORC086_23095 ENOG4108JGH Tetr family transcriptional regulator FORC086_23100 ENOG4105CN9 Peptidase m42 family protein FORC086_23120 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FORC086_23125 ENOG4105C22 threonyL-tRNA synthetase FORC086_23130 ENOG4108TDW sporulation protein YtxC FORC086_23155 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FORC086_23165 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FORC086_23170 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FORC086_23180 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FORC086_23185 ENOG4105C2M dna polymerase I FORC086_23190 ENOG4105BZU Histidine kinase FORC086_23195 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC086_23220 ENOG4108HMX isocitrate dehydrogenase (NADP) FORC086_23225 ENOG4105BZN citrate synthase FORC086_23240 ENOG4108REF Sporulation integral membrane protein ytvi FORC086_23245 ENOG4105FS0 cytoplasmic membrane protein FORC086_23270 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FORC086_23275 ENOG4105C6K Malic enzyme FORC086_23280 ENOG4105C0B DNA polymerase III (alpha subunit) FORC086_23285 ENOG4105VV2 FORC086_23295 ENOG4105SFS phosphoesterase RecJ domain protein FORC086_23320 ENOG4105E8R UPF0173 metal-dependent hydrolase FORC086_23325 ENOG4105DC7 peptidase M24 FORC086_23360 ENOG4105Z7P Acetyltransferase (GNAT) family FORC086_23365 ENOG41082W1 Cupin 2, conserved barrel domain protein FORC086_23385 ENOG4107YZX Universal stress protein FORC086_23430 ENOG4108JYZ YitT family FORC086_23450 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FORC086_23460 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FORC086_23465 ENOG4105KBJ sporulation protein ytfj FORC086_23480 ENOG4105EFZ amidohydrolase FORC086_23490 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FORC086_23515 ENOG4105RQF LysR family Transcriptional regulator FORC086_23525 ENOG4105U5Y Transcriptional regulator FORC086_23535 ENOG4105C28 cystathionine FORC086_23565 ENOG4108IBT Inherit from COG: transposase FORC086_23570 ENOG4108IBT Inherit from COG: transposase FORC086_23600 ENOG4108UW5 maltose o-acetyltransferase FORC086_23610 ENOG4105F1V Acetoin utilization protein FORC086_23615 ENOG4105W87 Cbs domain FORC086_23620 ENOG4105DGU Histone deacetylase FORC086_23635 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FORC086_23645 ENOG4107SNB ankyrin repeat protein YahD FORC086_23650 ENOG4105EP9 oxidoreductase FORC086_23680 ENOG4105ETE Transcriptional regulator (LacI family FORC086_23690 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FORC086_23710 ENOG4105C88 aminopeptidase FORC086_23745 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FORC086_23755 ENOG4108VDD TRNA binding domain protein FORC086_23785 ENOG4105C8F Beta-lactamase domain protein FORC086_23800 ENOG4108V15 phosphotransferase enzyme family FORC086_23805 ENOG4108IUM Glycogen debranching enzyme FORC086_23815 ENOG4107QSE Dipeptidase FORC086_23820 ENOG4105YW5 deoR family transcriptional regulator FORC086_23835 ENOG4105CBX hi0933 family FORC086_23875 ENOG4108VJ1 Transcriptional regulator (CarD family FORC086_23880 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FORC086_23885 ENOG4105CSC Glucose uptake protein FORC086_23900 ENOG4108ZAF Molybdopterin FORC086_23905 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FORC086_23910 ENOG4105CVM Molybdenum cofactor synthesis domain protein FORC086_23920 ENOG4105D06 uba thif-type nad fad binding protein FORC086_23925 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FORC086_23950 ENOG41085GJ domain protein FORC086_23960 ENOG4105DWV Homoserine O-trans-acetylase FORC086_23970 ENOG4108B31 Spore germination protein FORC086_24000 ENOG410605W Major Facilitator FORC086_24005 ENOG4107S91 Sodium hydrogen exchanger FORC086_24010 ENOG4105NCW Trka-c domain protein FORC086_24025 ENOG4105C19 ABC transporter FORC086_24045 ENOG4105N5T Radical SAM Protein FORC086_24085 ENOG4105E8V Alpha Beta Hydrolase Fold protein FORC086_24090 ENOG4108Z0R Transferase FORC086_24095 ENOG4105YVM Phosphoesterase, PA-phosphatase related FORC086_24100 ENOG4105BZF Glycosyl transferase (Group 1 FORC086_24110 ENOG4105EPU Molybdenum cofactor synthesis domain protein FORC086_24120 ENOG4108MK9 spermidine N(1)-acetyltransferase FORC086_24180 ENOG4105E98 transcriptional regulator DeoR family FORC086_24220 ENOG4105BZU Histidine kinase FORC086_24225 ENOG4105BZU Histidine kinase FORC086_24230 ENOG4105CH6 catalase FORC086_24240 ENOG4107S9D Alpha beta hydrolase FORC086_24245 ENOG4107T7U Sulfatase FORC086_24270 ENOG4105D2X ABC transporter substrate-binding protein FORC086_24280 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FORC086_24345 ENOG4108V2W Carbonate dehydratase FORC086_24350 ENOG4105C4M (Ubiquinol oxidase) subunit I FORC086_24355 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FORC086_24395 ENOG41087YS Phage shock protein A FORC086_24425 ENOG4105BZU Histidine kinase FORC086_24430 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC086_24455 ENOG4108UGV hypoxanthine phosphoribosyltransferase FORC086_24460 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FORC086_24505 ENOG4107ZTW SNARE associated Golgi FORC086_24520 ENOG4105C19 ABC transporter FORC086_24525 ENOG41086D8 Transcriptional regulator FORC086_24550 ENOG41082BM Transcriptional regulator, arsr family FORC086_24590 ENOG4105C6Z Gluconate FORC086_24595 ENOG4105FDP GntR family transcriptional regulator FORC086_24615 ENOG41069H0 dihydroorotase EC 3.5.2.3 FORC086_24635 ENOG4105DTQ mandelate racemase muconate lactonizing FORC086_24640 ENOG4105CEY Amp-dependent synthetase and ligase FORC086_24645 ENOG4108IPT Naphthoate synthase FORC086_24650 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FORC086_24655 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FORC086_24660 ENOG4105E4F Isochorismate synthase FORC086_24665 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FORC086_24675 ENOG4105VEQ Cold shock protein FORC086_24715 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FORC086_24730 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FORC086_24740 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FORC086_24835 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FORC086_24875 ENOG4105KT7 mgtC SapB transporter FORC086_24880 ENOG4107PBV potassium channel FORC086_24900 ENOG4105WG9 Conserved Protein FORC086_24910 ENOG4105CHM Aminotransferase FORC086_24915 ENOG4108ZB6 transcriptional regulator AsnC family FORC086_24920 ENOG4105C5I Dehydrogenase FORC086_24925 ENOG4108MUZ hydrolase FORC086_24935 ENOG4105C87 Aminotransferase class I and II FORC086_24945 ENOG4105Y38 Kinase-associated protein B FORC086_24955 ENOG4107R3E Citrate transporter FORC086_24975 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FORC086_24980 ENOG4105KA0 thioesterase Superfamily protein FORC086_24995 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FORC086_25020 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) FORC086_25025 ENOG4106YN8 Prenyltransferase FORC086_25035 ENOG41069ER domain protein FORC086_25050 ENOG4105CEP NADH dehydrogenase FORC086_25080 ENOG4105EWC Purine nucleoside phosphorylase FORC086_25100 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FORC086_25125 ENOG4108JJA ABC, transporter FORC086_25130 ENOG4105C4B ABC transporter, permease FORC086_25140 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FORC086_25180 ENOG41083MR nifu domain-containing protein FORC086_25195 ENOG4108W5N phosphatidylglycerophosphatase a FORC086_25215 ENOG4105DAX Pfam:DUF2983 FORC086_25225 ENOG4105DYS nad(p)h dehydrogenase (quinone) FORC086_25230 ENOG4105D4U had-superfamily hydrolase, subfamily iia FORC086_25245 ENOG4105CBT Fructose-1,6-bisphosphatase FORC086_25270 ENOG4105MMD transcriptional regulator FORC086_25275 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FORC086_25280 ENOG4107TXC Transcriptional regulator FORC086_25285 ENOG41090T1 Membrane FORC086_25310 ENOG4105FAA peptidase M23 FORC086_25315 ENOG4108YTE sporulation protein YunB FORC086_25320 ENOG4105KZD Domain of unknown function (DUF1805) FORC086_25325 ENOG4107R8B 5'-nucleotidase FORC086_25335 ENOG4105DIW FeS assembly protein SUFB FORC086_25340 ENOG4108UNV SUF system FeS assembly protein, NifU family FORC086_25345 ENOG4105C9B Cysteine desulfurase FORC086_25350 ENOG4105JRK feS assembly protein SufD FORC086_25355 ENOG4105C3K feS assembly ATPase SufC FORC086_25360 ENOG4105D01 (LipO)protein FORC086_25365 ENOG4105D01 (LipO)protein FORC086_25370 ENOG4108UMI ABC transporter, permease FORC086_25375 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FORC086_25400 ENOG41080E8 Transcriptional regulator, Spx MgsR family FORC086_25420 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FORC086_25445 ENOG4108W8B Beta-lactamase domain protein FORC086_25450 ENOG4105C1G acyl-Coa dehydrogenase FORC086_25460 ENOG4105CHU acetyl-coa acetyltransferase FORC086_25480 ENOG4105DZ1 carboxypeptidase FORC086_25500 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FORC086_25515 ENOG4108SUT Major Facilitator Superfamily FORC086_25520 ENOG4107R7I amino acid FORC086_25535 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FORC086_25545 ENOG4107AYK membrAne FORC086_25585 ENOG4107ZTW SNARE associated Golgi FORC086_25595 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FORC086_25600 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC086_25605 ENOG4105BZU Histidine kinase FORC086_25635 ENOG4105C8Q Methyl-accepting chemotaxis FORC086_25640 ENOG4105VG1 fes assembly suf system protein FORC086_25645 ENOG4105D4Y metalloprotease FORC086_25650 ENOG4105C2I pirin domain protein FORC086_25665 ENOG4107T5V SNARE associated Golgi FORC086_25670 ENOG4107S91 Sodium hydrogen exchanger FORC086_25675 ENOG4105NCW Trka-c domain protein FORC086_25690 ENOG4108RMU ferritin dps family protein FORC086_25710 ENOG4108URH decarboxylase FORC086_25720 ENOG41090A1 ferritin FORC086_25730 ENOG4105D9N nucleoside FORC086_25735 ENOG4105D9N nucleoside FORC086_25750 ENOG4108RYK Nad-dependent epimerase dehydratase FORC086_25770 ENOG4105CV8 reductase FORC086_25775 ENOG4105F27 Major Facilitator FORC086_25780 ENOG4105KVH Transcriptional regulator FORC086_25795 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FORC086_25800 ENOG4105D4A Cell wall formation (By similarity) FORC086_25820 ENOG4105WMR Protein CrcB homolog FORC086_25825 ENOG4105WMR Protein CrcB homolog FORC086_25845 ENOG4105C5H ABC transporter FORC086_25850 ENOG4108MK9 spermidine N(1)-acetyltransferase FORC086_25855 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FORC086_25870 ENOG4108W2Y isochorismatase FORC086_25890 ENOG4108V2W Carbonate dehydratase FORC086_25895 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) FORC086_25915 ENOG4108IPW abc transporter atp-binding protein FORC086_25920 ENOG4105CM4 permease protein FORC086_25995 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FORC086_26005 ENOG4105XZU Preprotein translocase, subunit SecG FORC086_26010 ENOG41067MG lrgb family FORC086_26030 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FORC086_26060 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC086_26065 ENOG4105RHA ABC transporter, permease FORC086_26070 ENOG4108IUX (ABC) transporter FORC086_26075 ENOG4105BZU Histidine kinase FORC086_26080 ENOG4108VB1 regulatoR FORC086_26100 ENOG41090VF Stage v sporulation protein ac FORC086_26105 ENOG4105CZ3 stage V sporulation protein ad FORC086_26120 ENOG4108QY0 Membrane FORC086_26125 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FORC086_26130 ENOG4105KRI phosphocarrier protein (HPr FORC086_26140 ENOG4105CHW UPF0052 protein FORC086_26145 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FORC086_26150 ENOG4108Z4K mutator MutT protein FORC086_26160 ENOG4105C3M thioredoxin reductase FORC086_26170 ENOG4108S4C acetyltransferase FORC086_26190 ENOG41086DT Membrane protein of unknown function FORC086_26200 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FORC086_26205 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FORC086_26220 ENOG4107TXC Transcriptional regulator FORC086_26245 ENOG4105HMI Membrane FORC086_26250 ENOG4105DUM transcriptional regulator, lysR family FORC086_26260 ENOG4108WS4 fmn reductase FORC086_26275 ENOG4105BZ1 (ABC) transporter FORC086_26285 ENOG4105CN1 protease FORC086_26290 ENOG4105CRP Part of the ABC transporter FtsEX involved in FORC086_26295 ENOG4105CAK Cell division ATP-binding protein ftsE FORC086_26325 ENOG4105MS2 ribosomal subunit Interface protein FORC086_26330 ENOG4105VEQ Cold shock protein FORC086_26335 ENOG41081UC Inherit from COG: Competence protein FORC086_26350 ENOG4105KVH Transcriptional regulator FORC086_26365 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FORC086_26370 ENOG4108KGH TRANSCRIPTIONal FORC086_26375 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FORC086_26380 ENOG4105C6Y Udp-glucose 6-dehydrogenase FORC086_26385 ENOG4105ESV Glycosyl transferase, family 4 FORC086_26395 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FORC086_26415 ENOG4105F8D glycoside hydrolase family 4 FORC086_26420 ENOG4105VCP PTS System FORC086_26425 ENOG4105CK1 PTS System FORC086_26435 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FORC086_26440 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FORC086_26445 ENOG4105VCP PTS System FORC086_26455 ENOG4105VZJ PTS System FORC086_26475 ENOG4105ECB domain protein FORC086_26480 ENOG4107RSM transcriptional regulator FORC086_26535 ENOG4105DAA L-lactate FORC086_26545 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FORC086_26560 ENOG4105E0M Sulfatase FORC086_26590 ENOG4107R8N Glycosyl transferase, family 2 FORC086_26600 ENOG4105C94 Transporter FORC086_26610 ENOG41069ER domain protein FORC086_26640 ENOG4105KBK Zinc finger, swim domain protein FORC086_26645 ENOG4105C0D helicase FORC086_26675 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FORC086_26685 ENOG4107RBB ABC transporter, permease FORC086_26690 ENOG4105C19 ABC transporter FORC086_26710 ENOG4105CXY transporter FORC086_26725 ENOG4105BZU Histidine kinase FORC086_26730 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC086_26735 ENOG4105CMR udp-glucose 4-epimerase FORC086_26745 ENOG4108KGH TRANSCRIPTIONal FORC086_26755 ENOG4105K64 Glycosyl transferase, family 2 FORC086_26770 ENOG4107T8Q Glycosyl transferase (Group 1 FORC086_26780 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) FORC086_26785 ENOG4105CPF Cell wall formation (By similarity) FORC086_26790 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FORC086_26800 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FORC086_26805 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FORC086_26810 ENOG4107YJ4 chain length determinant protein FORC086_26815 ENOG4105HTX biosynthesis protein FORC086_26820 ENOG4107YJ4 chain length determinant protein FORC086_26835 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FORC086_26845 ENOG4105FRN stage II sporulation protein FORC086_26860 ENOG4105DY9 regulatoR FORC086_26880 ENOG4106778 Protein of unknown function (DUF1146) FORC086_26885 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FORC086_26890 ENOG4105C8S subunit m FORC086_26895 ENOG4105D65 subunit l FORC086_26920 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FORC086_26925 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FORC086_26935 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FORC086_26940 ENOG4105BZU Histidine kinase FORC086_27000 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FORC086_27005 ENOG41062M3 atp synthase FORC086_27025 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FORC086_27030 ENOG4108UIC UPF0340 protein FORC086_27035 ENOG4108YZG isomerase FORC086_27055 ENOG4108VGI doxx family FORC086_27060 ENOG4107XC4 flavin reductase domain protein, FMN-binding FORC086_27080 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FORC086_27090 ENOG4108ZXQ stage ii sporulation protein r FORC086_27095 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FORC086_27100 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FORC086_27105 ENOG4107104 thymidine kinase FORC086_27115 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FORC086_27120 ENOG4105CBT Fructose-1,6-bisphosphatase FORC086_27125 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FORC086_27145 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FORC086_27160 ENOG4105C1G acyl-Coa dehydrogenase FORC086_27165 ENOG4105C1G acyl-Coa dehydrogenase FORC086_27170 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FORC086_27180 ENOG4105DF6 Fe-S oxidoreductase FORC086_27195 ENOG4105BZU Histidine kinase FORC086_27210 ENOG4105D4Y metalloprotease FORC086_27220 ENOG4105BZU Histidine kinase FORC086_27225 ENOG4105KCT ABC transporter FORC086_27230 ENOG4108M15 ABC transporter FORC086_27235 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FORC086_27245 ENOG4105IIU Aminopeptidase FORC086_27265 ENOG4105DU6 RNA polymerase FORC086_27275 ENOG410684U Domain of unknown function (DUF1934) FORC086_27300 ENOG4105CYW agmatinase FORC086_27310 ENOG4105DXB Major Facilitator superfamily FORC086_27315 ENOG4107SWG transcriptional regulator MERR family FORC086_27320 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FORC086_27325 ENOG4105BZ4 penicillin-binding protein FORC086_27330 ENOG4108XFG YwhD family FORC086_27335 ENOG4108Z4T Peptidase M50 FORC086_27340 ENOG41069HH 4-oxalocrotonate tautomerase FORC086_27345 ENOG4105DCI Phosphohydrolase FORC086_27350 ENOG4108MES Periplasmic binding protein FORC086_27355 ENOG4105E0A ABC, transporter FORC086_27360 ENOG4105EHG Permease protein FORC086_27365 ENOG4105DQ5 transport system permease protein FORC086_27375 ENOG4108VCI transcription factor, rsfa family FORC086_27380 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) FORC086_27385 ENOG4108IJ2 phosphate acetyltransferase FORC086_27390 ENOG4107UEZ chlorite dismutase FORC086_27400 ENOG4108VKI Cell wall hydrolase FORC086_27420 ENOG4107SVH Potassium channel protein FORC086_27430 ENOG410667J hydrolase FORC086_27435 ENOG4105VCH membrane FORC086_27445 ENOG4108TU7 Inherit from COG: (ABC) transporter FORC086_27450 ENOG4105CJ1 ABC, transporter FORC086_27455 ENOG41090WU lipolytic protein G-D-S-L family FORC086_27470 ENOG4105D6E homoserine dehydrogenase FORC086_27495 ENOG4108Y4K DNA-binding transcriptional activator FORC086_27505 ENOG4105WH1 Two component transcriptional regulator luxr family FORC086_27510 ENOG4105BZU Histidine kinase FORC086_27515 ENOG4105DWF phosphomethylpyrimidine kinase FORC086_27520 ENOG4105BZU Histidine kinase FORC086_27525 ENOG4105VCD cytoplasmic protein FORC086_27530 ENOG4105D22 carbon starvation protein FORC086_27535 ENOG4105DY9 regulatoR FORC086_27540 ENOG41079KZ Major Facilitator Superfamily FORC086_27555 ENOG4105CG5 Glycosyl transferase (Group 1 FORC086_27565 ENOG4105EN6 Membrane FORC086_27570 ENOG4106YBV Methyl-accepting chemotaxis FORC086_27580 ENOG4108S4H thioesterase Superfamily protein FORC086_27585 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) FORC086_27595 ENOG4105K64 Glycosyl transferase, family 2 FORC086_27605 ENOG4105EJV Membrane FORC086_27610 ENOG4105CKK Glycosyl transferase, family 2 FORC086_27615 ENOG4105C5H ABC transporter FORC086_27620 ENOG41067SE Tetr family transcriptional regulator FORC086_27630 ENOG4105E0X reductase FORC086_27635 ENOG4106F5Q Membrane FORC086_27650 ENOG4108NEV two component transcriptional regulator, LytTR family FORC086_27655 ENOG4108HRK Histidine kinase FORC086_27660 ENOG4107RGD Major Facilitator superfamily FORC086_27680 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FORC086_27690 ENOG4105IW1 AmiS UreI transporter FORC086_27700 ENOG4105CMR udp-glucose 4-epimerase FORC086_27705 ENOG4108UT2 hemolysin iii FORC086_27715 ENOG4105C1J atp-dependent rna helicase FORC086_27720 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) FORC086_27725 ENOG4105DPN Oligoendopeptidase f FORC086_27735 ENOG4105BZU Histidine kinase FORC086_27740 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) FORC086_27750 ENOG4105C0H protease FORC086_27755 ENOG4105Q2H domain protein FORC086_27770 ENOG4105BZU Histidine kinase FORC086_27775 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FORC086_27800 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FORC086_27805 ENOG4105CDU Replicative dna helicase FORC086_27815 ENOG4105BZR domain protein FORC086_27830 ENOG4108UUM single-stranded DNA-binding protein FORC086_27840 ENOG4105C3G gtp-binding protein FORC086_27845 ENOG4105VDK protein, conserved in bacteria FORC086_27850 ENOG4105D8X mechanosensitive ion channel FORC086_27855 ENOG4108ZDA Sporulation protein YyaC FORC086_27860 ENOG4105FA0 parb-like partition protein FORC086_27865 ENOG4107QJE Chromosome Partitioning Protein FORC086_27880 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FORC086_27885 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FORC086_27895 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins