locus-tag class description AQ16_10 ENOG4105ETU transcriptional activator (TenA AQ16_1002 ENOG4108S6Z Negative regulator of genetic competence AQ16_1003 ENOG4107X2D transcriptional regulator, merr family AQ16_1004 ENOG4107RGJ metallophosphoesterase AQ16_1006 ENOG4105I7S Abortive infection protein AQ16_1007 ENOG4105C9U ATP-dependent DNA helicase RecQ AQ16_1010 ENOG4108SAX Membrane AQ16_1012 ENOG41063SB peptidase AQ16_1013 ENOG4108WBT adenosyltransferase AQ16_1014 ENOG4105BZU Histidine kinase AQ16_1015 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AQ16_1016 ENOG4105CRE cytochrome C AQ16_1017 ENOG4107TWT Cytochrome c biogenesis protein AQ16_1019 ENOG4105FE9 pseudouridine synthase AQ16_1021 ENOG4108JIC nucleoside recognition domain protein AQ16_1022 ENOG4105DZ1 carboxypeptidase AQ16_1023 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AQ16_103 ENOG4105EQK -acetyltransferase AQ16_1030 ENOG4105BZU Histidine kinase AQ16_1033 ENOG4105I3N Conserved Protein AQ16_1034 ENOG4105BZU Histidine kinase AQ16_1037 ENOG4105BZ4 penicillin-binding protein AQ16_1038 ENOG4107GRR phosphate transport regulator AQ16_1039 ENOG4105CJ3 phosphate transporter AQ16_1048 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AQ16_105 ENOG4105CIN aminoacyl-histidine dipeptidase AQ16_1052 ENOG4105WH1 Two component transcriptional regulator luxr family AQ16_1053 ENOG4105ENE Histidine kinase AQ16_1057 ENOG4105DFD Na H antiporter AQ16_1061 ENOG4105C8J )-transporter AQ16_1062 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AQ16_1063 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AQ16_1064 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AQ16_1066 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AQ16_1067 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AQ16_1071 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AQ16_1073 ENOG4105E0M Sulfatase AQ16_1074 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AQ16_1075 ENOG4105C5I Dehydrogenase AQ16_1077 ENOG4107RVV histidinol phosphate phosphatase, hisj family AQ16_109 ENOG4105K56 Transcriptional regulator AQ16_1092 ENOG4108ZP8 Acetolactate synthase small subunit AQ16_1093 ENOG4105C7K acetolactate synthase AQ16_1094 ENOG4105CM2 brancheD-chain amino acid aminotransferase AQ16_1098 ENOG4105KBJ sporulation protein ytfj AQ16_1099 ENOG41063Y9 AQ16_110 ENOG4107RA9 decarboxylase AQ16_1100 ENOG4105CZN Potassium uptake protein AQ16_1107 ENOG4107QMU Mate efflux family protein AQ16_111 ENOG4108I0C methyltransferase AQ16_1114 ENOG4105NQC Flavodoxin AQ16_1119 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AQ16_1121 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AQ16_1122 ENOG4105EA8 2-Nitropropane dioxygenase AQ16_1123 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AQ16_113 ENOG41088CC tellurite resistance protein tehB AQ16_1131 ENOG4105CJ1 ABC, transporter AQ16_1133 ENOG4105CZV ABC transporter AQ16_1134 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AQ16_1135 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AQ16_1136 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AQ16_1137 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AQ16_1138 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AQ16_114 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AQ16_1146 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AQ16_1147 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase AQ16_1149 ENOG4105BZU Histidine kinase AQ16_1151 ENOG4106DF1 AQ16_1153 ENOG41090MY MarR family Transcriptional regulator AQ16_1154 ENOG4105BZU Histidine kinase AQ16_1156 ENOG4105PXI polysaccharide deacetylase AQ16_1158 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) AQ16_1161 ENOG4105E98 transcriptional regulator DeoR family AQ16_1164 ENOG4108KAZ Involved in phosphonate degradation (By similarity) AQ16_1165 ENOG4107RCV ABC transporter, permease AQ16_1166 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AQ16_1167 ENOG4105C4Y ABC transporter AQ16_117 ENOG4108RZE Tetr family transcriptional regulator AQ16_1173 ENOG4105CHR reductase AQ16_1177 ENOG4108Z7G MaoC domain protein dehydratase AQ16_1178 ENOG410681C small acid-soluble spore protein AQ16_1179 ENOG4105CZN Potassium uptake protein AQ16_1180 ENOG4107TS3 membrane protein, TerC AQ16_1181 ENOG4108QTI )-transporter AQ16_1183 ENOG4106A3R peptidase AQ16_1187 ENOG4105JXH GntR family transcriptional regulator AQ16_1188 ENOG4105BZU Histidine kinase AQ16_1189 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AQ16_1192 ENOG4105CQB FAD linked oxidase domain protein AQ16_1193 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AQ16_1194 ENOG4105K4I Scp-like extracellular AQ16_1196 ENOG4108YBP pseudouridine synthase AQ16_1198 ENOG4105EYF MMPL domain protein AQ16_1200 ENOG4107RUE extracellular solute-binding protein family 1 AQ16_1201 ENOG4105D38 putrescine abc transporter AQ16_1202 ENOG4105F38 ABC transporter, permease AQ16_1204 ENOG4105C26 Dehydrogenase AQ16_1212 ENOG4105VFR signal peptidase AQ16_1213 ENOG4105DZ1 carboxypeptidase AQ16_1217 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AQ16_1218 ENOG4108NE4 AQ16_123 ENOG4105C1J atp-dependent rna helicase AQ16_1237 ENOG4105VZ8 Transcriptional regulator AQ16_1239 ENOG4105C7S Dehydrogenase AQ16_1248 ENOG4105T65 Membrane-associated protein AQ16_1255 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AQ16_1259 ENOG4105DDQ anthranilate synthase AQ16_126 ENOG4105D7V transposase AQ16_1260 ENOG4105CRQ synthase (Component I) AQ16_1261 ENOG4105CK7 Sodium proline symporter AQ16_127 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AQ16_1276 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase AQ16_1278 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AQ16_1279 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AQ16_1283 ENOG4107TVC Glycosyl transferase, family 2 AQ16_1287 ENOG4105K64 Glycosyl transferase, family 2 AQ16_1291 ENOG4105EMS pseudouridine synthase AQ16_1294 ENOG4106EFP UPF0738 protein AQ16_1295 ENOG4105MIX Adenylate cyclase AQ16_1296 ENOG4108Z18 K06886 hemoglobin AQ16_1299 ENOG4105DPN Oligoendopeptidase f AQ16_13 ENOG4105D6E homoserine dehydrogenase AQ16_1301 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AQ16_1303 ENOG4108ZCF integral membrane protein AQ16_1307 ENOG4105UQX Mate efflux family protein AQ16_1308 ENOG4108JQ7 (ABC) transporter AQ16_1310 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AQ16_1311 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AQ16_1314 ENOG4105C31 Tryptophanyl-tRNA synthetase AQ16_1317 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AQ16_1318 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AQ16_132 ENOG4108INS Transcriptional regulator AQ16_1326 ENOG4108KP7 hydrolase AQ16_1328 ENOG41073B9 AQ16_1329 ENOG4107AYK membrAne AQ16_1331 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AQ16_1334 ENOG4105CNA YD repeat protein AQ16_1337 ENOG4105CNA YD repeat protein AQ16_1338 ENOG4105QNR S1 RNA binding domain protein AQ16_1339 ENOG4108VPT UPF0234 protein AQ16_1341 ENOG4107A6P AQ16_1343 ENOG4105BZU Histidine kinase AQ16_1344 ENOG4105CH6 catalase AQ16_1346 ENOG4105CAQ asparagine synthetase AQ16_1351 ENOG4105ERH Fumarylacetoacetate hydrolase AQ16_136 ENOG4105RD7 BadF BadG BcrA BcrD AQ16_1365 ENOG4105XVF Competence transcription factor AQ16_1368 ENOG4105VEQ Cold shock protein AQ16_1371 ENOG4107QP3 malate synthase g AQ16_1372 ENOG4105ZU5 s-layer protein AQ16_1376 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 AQ16_1381 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AQ16_1385 ENOG41086D8 Transcriptional regulator AQ16_1386 ENOG4108AEY RNA polymerase sigma factor AQ16_1388 ENOG4107TVP HD domain protein AQ16_1389 ENOG4107RN3 metallophosphoesterase AQ16_1390 ENOG4105ENX hydrolase AQ16_1391 ENOG4105ST3 Transcriptional regulator AQ16_1392 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) AQ16_1394 ENOG4105CEY Amp-dependent synthetase and ligase AQ16_1396 ENOG4105DF9 Lipoate-protein, ligase AQ16_1397 ENOG4108RQ5 Beta-lactamase domain-containing protein AQ16_1398 ENOG4106AXD AQ16_1400 ENOG4108MK9 spermidine N(1)-acetyltransferase AQ16_1403 ENOG4105ECB domain protein AQ16_1409 ENOG4105C1Q protoporphyrinogen oxidase AQ16_141 ENOG4105F32 YngK protein AQ16_1410 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AQ16_1412 ENOG4105BZ4 penicillin-binding protein AQ16_1413 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation AQ16_1414 ENOG4105CKV Membrane AQ16_1415 ENOG410905X membrane-flanked domain protein AQ16_1418 ENOG4105CKV Membrane AQ16_1419 ENOG410905X membrane-flanked domain protein AQ16_1426 ENOG4105K59 histidine triad (HIT) protein AQ16_1431 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AQ16_1437 ENOG4105EMN RNA polymerase sigma factor AQ16_1439 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AQ16_1442 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AQ16_1445 ENOG4108MUZ hydrolase AQ16_1449 ENOG4105ED2 Beta-lactamase AQ16_1451 ENOG4106D4I domain protein AQ16_1452 ENOG4107VRP DNA repair exonuclease AQ16_146 ENOG4108KPJ rna polymerase sigma factor AQ16_1462 ENOG4105K8R UPF0145 protein AQ16_1467 ENOG4105BZU Histidine kinase AQ16_1468 ENOG4105BZU Histidine kinase AQ16_1469 ENOG4108MJI response regulator AQ16_1471 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AQ16_1473 ENOG4105WN5 stage II sporulation protein AQ16_1475 ENOG4107BMA Transglycosylase associated protein AQ16_1480 ENOG4108WC5 Alpha Beta Hydrolase Fold protein AQ16_1489 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AQ16_149 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AQ16_1494 ENOG4105CMT Dihydroxyacetone kinase AQ16_1496 ENOG4105CMT Dihydroxyacetone kinase AQ16_1500 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AQ16_1511 ENOG4105C0R drug resistance transporter emrb qaca subfamily AQ16_1515 ENOG4108Z86 Glutamine amidotransferase AQ16_1520 ENOG4105CDU Replicative dna helicase AQ16_1523 ENOG4105CDU Replicative dna helicase AQ16_154 ENOG4108JCI Transcriptional regulator AQ16_1541 ENOG4108MRH transcriptional regulatory protein AQ16_1543 ENOG4105CSH Transporter AQ16_1548 ENOG4105ESF Peptidoglycan binding domain protein AQ16_1553 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AQ16_1557 ENOG4105ESF Peptidoglycan binding domain protein AQ16_1564 ENOG4105CDU Replicative dna helicase AQ16_1575 ENOG4105DER m42 family AQ16_1579 ENOG4105CGU Enoyl-CoA hydratase AQ16_158 ENOG4105BZ1 (ABC) transporter AQ16_1581 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AQ16_1583 ENOG4106AKK s-layer domain-containing protein AQ16_159 ENOG4105BZ1 (ABC) transporter AQ16_1592 ENOG4105CHH sulfate transporter AQ16_1596 ENOG4107ZTW SNARE associated Golgi AQ16_1599 ENOG4105D4P Coproporphyrinogen iii oxidase AQ16_1600 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AQ16_1605 ENOG4107FQX Alpha-acetolactate decarboxylase AQ16_1614 ENOG410839P AQ16_1617 ENOG4105CDA abc transporter atp-binding protein AQ16_1618 ENOG4105DRP amino acid AbC transporter AQ16_1620 ENOG4105BZ1 (ABC) transporter AQ16_1621 ENOG4105BZ1 (ABC) transporter AQ16_1622 ENOG4105C26 Dehydrogenase AQ16_1624 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AQ16_1625 ENOG4105D5Q Arginine ornithine antiporter AQ16_1627 ENOG4107RKG DJ-1/PfpI family AQ16_163 ENOG4108RPX mosc domain containing protein AQ16_1630 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF AQ16_1635 ENOG4105C19 ABC transporter AQ16_1636 ENOG4107RBB ABC transporter, permease AQ16_1637 ENOG4105C19 ABC transporter AQ16_164 ENOG4105DND Transcriptional regulator AQ16_1644 ENOG4105KPY Small multidrug resistance protein AQ16_1645 ENOG4105KPY Small multidrug resistance protein AQ16_1649 ENOG4108YXU transcriptional regulator AsnC family AQ16_1657 ENOG4106KNT transcriptional regulator AQ16_1659 ENOG4107RWR Sodium hydrogen exchanger AQ16_1660 ENOG4105CUB amino acid AQ16_1667 ENOG4107T5V SNARE associated Golgi AQ16_167 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AQ16_1674 ENOG4105WEF catalase AQ16_168 ENOG4107V2S Transcriptional regulator AQ16_1681 ENOG4105C19 ABC transporter AQ16_1682 ENOG4107RBB ABC transporter, permease AQ16_1683 ENOG41069ER domain protein AQ16_1687 ENOG4105VZJ PTS System AQ16_1688 ENOG4105VCP PTS System AQ16_1689 ENOG4105EMD TRANSCRIPTIONal AQ16_1694 ENOG4108KGH TRANSCRIPTIONal AQ16_1696 ENOG41087NI Sulfite exporter TauE/SafE AQ16_1697 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase AQ16_1699 ENOG4105VFE sira family AQ16_170 ENOG410667J hydrolase AQ16_1701 ENOG4105VFE sira family AQ16_1702 ENOG4105VFE sira family AQ16_1703 ENOG4107TPS domain protein AQ16_1704 ENOG4105VFE sira family AQ16_1705 ENOG4105XTG Pfam:DUF156 AQ16_1706 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase AQ16_1708 ENOG4108TCS Glutamyl endopeptidase AQ16_1710 ENOG4105ED1 spovr family AQ16_1711 ENOG4107Y03 Nitroreductase AQ16_1715 ENOG4108B31 Spore germination protein AQ16_1719 ENOG4105K63 Thioredoxin AQ16_1722 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AQ16_1724 ENOG4105C7N Xanthine uracil vitamin C permease AQ16_1726 ENOG4105DQ6 Transposase AQ16_1728 ENOG4105C19 ABC transporter AQ16_1733 ENOG4108INS Transcriptional regulator AQ16_174 ENOG4105VEQ Cold shock protein AQ16_1743 ENOG4105DWF phosphomethylpyrimidine kinase AQ16_1744 ENOG4105D06 uba thif-type nad fad binding protein AQ16_1747 ENOG41080HI glycine oxidase AQ16_1748 ENOG4108VEU Thiamine monophosphate synthase AQ16_1750 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AQ16_1752 ENOG4105ETU transcriptional activator (TenA AQ16_1756 ENOG41080XQ Signal transduction protein with cbs domains AQ16_176 ENOG41068WN AQ16_178 ENOG4105C1Q protoporphyrinogen oxidase AQ16_1784 ENOG4105E2Z phosphate ABC transporter (Permease AQ16_1785 ENOG4105C8U phosphate abc transporter AQ16_1786 ENOG4105CVA phosphate AQ16_1787 ENOG4105CE1 Ferrous iron transport protein b AQ16_1788 ENOG4105CE1 Ferrous iron transport protein b AQ16_1789 ENOG4105CE1 Ferrous iron transport protein b AQ16_179 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AQ16_1790 ENOG4108NHD germination protein AQ16_1793 ENOG4105E1V na solute symporter AQ16_1794 ENOG4106CAD Protein of unknown function (DUF3311) AQ16_1798 ENOG4105E2S oxidase) subunit II AQ16_1799 ENOG4105BZ9 Cytochrome C oxidase, subunit I AQ16_1800 ENOG4105CCU oxidase (Subunit III) AQ16_1803 ENOG4105MA6 gCN5-related N-acetyltransferase AQ16_1806 ENOG4105C7N Xanthine uracil vitamin C permease AQ16_1807 ENOG4105C85 amino acid AQ16_1811 ENOG4105DUX Transporter AQ16_1813 ENOG4107D63 AQ16_1814 ENOG4105VZ8 Transcriptional regulator AQ16_1815 ENOG41069ER domain protein AQ16_1816 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AQ16_1817 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AQ16_1828 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AQ16_1829 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AQ16_1830 ENOG4105CNN ABC, transporter AQ16_1831 ENOG4105C2J ABC transporter AQ16_1833 ENOG4108RVA ribokinase AQ16_1834 ENOG4105ETE Transcriptional regulator (LacI family AQ16_1835 ENOG4105C0R drug resistance transporter emrb qaca subfamily AQ16_1836 ENOG41067TZ transcriptional regulator, MarR family AQ16_1837 ENOG4105CXY transporter AQ16_1839 ENOG4108JQ7 (ABC) transporter AQ16_184 ENOG4105WCN acetyltransferase AQ16_1840 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AQ16_1844 ENOG41068KF Universal stress protein AQ16_1845 ENOG4105CHH sulfate transporter AQ16_1848 ENOG4105BZU Histidine kinase AQ16_1849 ENOG4105NAE bifunctional deaminase-reductase domain protein AQ16_1850 ENOG4105D29 Helix-turn-helix type 11 domain protein AQ16_1855 ENOG4108IQI permease AQ16_1856 ENOG4105DRP amino acid AbC transporter AQ16_1857 ENOG4105EAD ABC transporter AQ16_1858 ENOG4105CT1 (ABC) transporter AQ16_1859 ENOG4105CDA abc transporter atp-binding protein AQ16_1860 ENOG4105BZG amino acid carrier protein AQ16_1861 ENOG4105CRN Aminoglycoside phosphotransferase AQ16_1863 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AQ16_1864 ENOG4105WH1 Two component transcriptional regulator luxr family AQ16_1865 ENOG4108XG2 Histidine kinase AQ16_1866 ENOG4105E1K spore germination protein AQ16_1870 ENOG4105CG3 alpha amylase, catalytic region AQ16_1871 ENOG4105C5Y PTS System AQ16_1872 ENOG4107414 GntR family transcriptional regulator AQ16_1873 ENOG4105D5Q Arginine ornithine antiporter AQ16_1874 ENOG4105BZU Histidine kinase AQ16_1877 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AQ16_1878 ENOG4105GMT ATPase associated with various cellular activities aaa_5 AQ16_1879 ENOG4107T89 von Willebrand factor, type A AQ16_188 ENOG4105EYF MMPL domain protein AQ16_1881 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) AQ16_1882 ENOG4105EXW epimerase dehydratase AQ16_1884 ENOG4105DMQ Methyltransferase AQ16_1885 ENOG4105E0A ABC, transporter AQ16_1886 ENOG4108IHU transport system permease protein AQ16_1887 ENOG4105DQ5 transport system permease protein AQ16_1888 ENOG4108MES Periplasmic binding protein AQ16_1889 ENOG4105DUX Transporter AQ16_1892 ENOG4105DAA L-lactate AQ16_1893 ENOG4108IJ0 Aspartate ammonia-lyase AQ16_1894 ENOG4105C37 (CBS) domain AQ16_1895 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AQ16_1896 ENOG4105D9N nucleoside AQ16_1897 ENOG4108KGH TRANSCRIPTIONal AQ16_1898 ENOG41073R8 VanW family AQ16_1905 ENOG4105DAP Nicotinate phosphoribosyltransferase AQ16_1906 ENOG4105C59 p-type ATPase AQ16_1908 ENOG4105CUB amino acid AQ16_191 ENOG4107MII Sugar-specific transcriptional regulator TrmB AQ16_1912 ENOG4108JB9 formate dehydrogenase AQ16_1913 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AQ16_1914 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AQ16_1916 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AQ16_1917 ENOG4105BZU Histidine kinase AQ16_1919 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AQ16_1920 ENOG4108UZ3 Transporter AQ16_1922 ENOG4105C6K Malic enzyme AQ16_1924 ENOG4108MRH transcriptional regulatory protein AQ16_1929 ENOG4105US7 Histidine kinase AQ16_1930 ENOG4108STX response regulator AQ16_1935 ENOG4105D4T Citrate transporter AQ16_1936 ENOG4108V9W transcriptional regulatory protein AQ16_1937 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AQ16_1939 ENOG4105DZ6 Band 7 protein AQ16_194 ENOG41081I9 integral membrane protein AQ16_1942 ENOG4105C94 Transporter AQ16_1945 ENOG4108WCX response regulator AQ16_1948 ENOG410695V Essential for the production of a quorum sensing system signal molecule, the autoinducing peptide (AIP). This quorum sensing system is responsible for the regulation of the expression of virulence factor genes. Involved in the proteolytic processing of AgrD, the precursor of AIP (By similarity) AQ16_1956 ENOG4108M15 ABC transporter AQ16_1964 ENOG4105CJ1 ABC, transporter AQ16_1966 ENOG4105CYN Serine protein kinase AQ16_1968 ENOG4105BZU Histidine kinase AQ16_1969 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AQ16_1971 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AQ16_1973 ENOG4107ZQN disulfide bond AQ16_1974 ENOG4108JQC penicillin-binding protein 1A AQ16_199 ENOG4108D32 Methyltransferase AQ16_1998 ENOG4105G5W regulator Fur family AQ16_1999 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AQ16_2003 ENOG4108IUW ABC transporter AQ16_2005 ENOG4105CBC glutamate synthase AQ16_2006 ENOG4107NBY Membrane AQ16_2007 ENOG4105BZ1 (ABC) transporter AQ16_2011 ENOG4106BXE AQ16_2012 ENOG4105CEN a g-specific adenine glycosylase AQ16_2013 ENOG41067AE Membrane-bound metal-dependent hydrolase AQ16_2019 ENOG4105ECP epimerase AQ16_2020 ENOG4105CI2 imidazolone-5-propionate hydrolase AQ16_2024 ENOG4105F1A Pyruvate formate-lyase AQ16_2027 ENOG4105C3I Nad-dependent epimerase dehydratase AQ16_2028 ENOG4107QQG Dehydrogenase AQ16_2029 ENOG4105CKK Glycosyl transferase, family 2 AQ16_2033 ENOG4108A04 Beta-lactamase AQ16_2035 ENOG4105CSV Glutaminase AQ16_2041 ENOG4108IQI permease AQ16_2043 ENOG4108JUB Transcriptional regulator AQ16_2053 ENOG4105UPD Calcium Proton AQ16_2054 ENOG410606W general stress protein AQ16_2057 ENOG4107ZTW SNARE associated Golgi AQ16_2059 ENOG4105C3F Signal peptidase i AQ16_2061 ENOG4108IPJ Membrane AQ16_2062 ENOG4105C59 p-type ATPase AQ16_2063 ENOG4107U9T Pfam:Ribonuclease_BN AQ16_2065 ENOG4105KJF protein tyrosine phosphatase AQ16_2069 ENOG4108TTB tellurium resistance protein AQ16_207 ENOG4105C19 ABC transporter AQ16_2070 ENOG4107TS3 membrane protein, TerC AQ16_2071 ENOG4106FN3 tellurium resistance protein AQ16_2072 ENOG4106FN3 tellurium resistance protein AQ16_2073 ENOG4108N0M stress protein AQ16_2079 ENOG4105DEU major facilitator superfamily AQ16_2083 ENOG41062JF Transcriptional regulator AQ16_209 ENOG4105C22 threonyL-tRNA synthetase AQ16_2090 ENOG4105C5H ABC transporter AQ16_2094 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AQ16_2097 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AQ16_210 ENOG4105FE9 pseudouridine synthase AQ16_2103 ENOG4105CI1 PTS System AQ16_2105 ENOG4105DNP FAD linked oxidase domain protein AQ16_2106 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AQ16_2108 ENOG4105EAB amino acid AbC transporter AQ16_2109 ENOG4105E5Q amino acid AbC transporter AQ16_2112 ENOG4105D2S major facilitator superfamily AQ16_2113 ENOG410756H nucleotidyltransferase AQ16_2121 ENOG4106UIA AQ16_2122 ENOG4106UIA AQ16_2126 ENOG4108V5C ABC transporter AQ16_2127 ENOG4105DQ5 transport system permease protein AQ16_2128 ENOG4105EHG Permease protein AQ16_2129 ENOG4107W7X Aldolase AQ16_2130 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) AQ16_2131 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) AQ16_2132 ENOG4105D3R alkyl hydroperoxide reductase AQ16_2137 ENOG4105DFD Na H antiporter AQ16_2138 ENOG4105DTQ mandelate racemase muconate lactonizing AQ16_214 ENOG4105BZG amino acid carrier protein AQ16_2141 ENOG4108W15 Protein of unknown function (DUF1456) AQ16_2142 ENOG4105BZU Histidine kinase AQ16_2144 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AQ16_2145 ENOG4105D9N nucleoside AQ16_2149 ENOG4105KPY Small multidrug resistance protein AQ16_2150 ENOG4105C26 Dehydrogenase AQ16_2152 ENOG4108JPW Aminotransferase AQ16_2154 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AQ16_2155 ENOG4105CBD Diacylglycerol kinase AQ16_2159 ENOG4107I77 yiaA/B two helix domain AQ16_2160 ENOG410834F Transcriptional regulator AQ16_2164 ENOG4105D01 (LipO)protein AQ16_2165 ENOG4108UMI ABC transporter, permease AQ16_2167 ENOG4108W2Y isochorismatase AQ16_2173 ENOG4105C4R Atp-dependent dna helicase AQ16_2178 ENOG4105C12 Phosphoribosylglycinamide synthetase AQ16_218 ENOG4105K70 DNA-binding protein AQ16_2180 ENOG4108V3E phosphoribosylglycinamide formyltransferase AQ16_2185 ENOG4105VR9 phosphoribosylformylglycinamidine synthase AQ16_2187 ENOG4105C83 adenylosuccinate lyase AQ16_2188 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AQ16_2189 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AQ16_2195 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AQ16_2200 ENOG4108SHN Glycosyl transferase, family 2 AQ16_2204 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AQ16_221 ENOG4105C0R drug resistance transporter emrb qaca subfamily AQ16_2212 ENOG4107ZXU DSBA oxidoreductase AQ16_2218 ENOG4105BZU Histidine kinase AQ16_2220 ENOG4105C7N Xanthine uracil vitamin C permease AQ16_2222 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AQ16_2224 ENOG4108TYN CAAX amino terminal protease family protein AQ16_2227 ENOG4105C5H ABC transporter AQ16_2229 ENOG410801F ribosomal-protein-alanine acetyltransferase AQ16_223 ENOG4105CEY Amp-dependent synthetase and ligase AQ16_2230 ENOG41072GX Peptidase M22 Glycoprotease AQ16_2231 ENOG4105K8N protein family UPF0079, ATPase AQ16_224 ENOG4105WQI isochorismatase AQ16_225 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AQ16_2251 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) AQ16_2253 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AQ16_2254 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein AQ16_2259 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AQ16_226 ENOG4105E4F Isochorismate synthase AQ16_2260 ENOG4105CPF Cell wall formation (By similarity) AQ16_2261 ENOG4108SC4 )-transporter AQ16_2262 ENOG4105CUB amino acid AQ16_2264 ENOG4105ERH Fumarylacetoacetate hydrolase AQ16_2265 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase AQ16_227 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AQ16_2271 ENOG410667J hydrolase AQ16_2272 ENOG4108JQ7 (ABC) transporter AQ16_2273 ENOG4105C3U ABC transporter AQ16_2274 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AQ16_2276 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein AQ16_2277 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein AQ16_2279 ENOG4108KYE ABC-2 type transporter AQ16_228 ENOG4105FCD Major Facilitator AQ16_2280 ENOG41090VJ ABC-2 type transporter AQ16_2281 ENOG4105CJ1 ABC, transporter AQ16_2282 ENOG4105WH1 Two component transcriptional regulator luxr family AQ16_2283 ENOG4105BZU Histidine kinase AQ16_2284 ENOG4105C5H ABC transporter AQ16_2287 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) AQ16_2290 ENOG4108RE7 deoxyribonuclease AQ16_2293 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AQ16_2297 ENOG4105F6E Acyl-transferase AQ16_2302 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family AQ16_2303 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AQ16_2304 ENOG4105E0C molybdate abc transporter AQ16_2306 ENOG4106Z1T Nicotinamide Mononucleotide Transporter AQ16_2307 ENOG4105II7 pyrroline-5-carboxylate reductase AQ16_2309 ENOG4108J59 Extracellular solute-binding protein, family 5 AQ16_2310 ENOG4108J59 Extracellular solute-binding protein, family 5 AQ16_2313 ENOG4108JQ7 (ABC) transporter AQ16_2314 ENOG4105C3U ABC transporter AQ16_2315 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AQ16_2316 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AQ16_2320 ENOG4105C2C drug resistance transporter, Bcr CflA AQ16_2324 ENOG4105IQ5 FAD linked oxidase domain protein AQ16_2326 ENOG4105EE1 crotonyl-CoA reductase AQ16_2327 ENOG4108PSK reductase AQ16_233 ENOG4107RFY SbcCD D subunit AQ16_2334 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AQ16_2336 ENOG4107U5W ybbr family AQ16_2337 ENOG4105C8B TIGR00159 family AQ16_2354 ENOG4108NMV polysaccharide deacetylase AQ16_2357 ENOG4105D1F ATP-binding protein AQ16_236 ENOG4105E39 Enoyl-CoA hydratase AQ16_2363 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AQ16_237 ENOG4105N14 lysine exporter protein LysE YggA AQ16_2370 ENOG41067V7 50S ribosomal protein L36 AQ16_2372 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AQ16_2374 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AQ16_2379 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AQ16_239 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AQ16_240 ENOG4105C1G acyl-Coa dehydrogenase AQ16_2400 ENOG4105XPM ribosomal protein AQ16_2403 ENOG4107Y49 methyltransferase AQ16_2408 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AQ16_241 ENOG4105CR4 methylisocitrate lyase AQ16_2410 ENOG4105QIV RNA polymerase AQ16_2411 ENOG4105M0M Tetracycline resistance protein AQ16_2412 ENOG4105C2N RNA methyltransferase TrmH family group 3 AQ16_2415 ENOG4105D7W serine acetyltransferase AQ16_2419 ENOG4105CTP PilT protein domain protein AQ16_242 ENOG4105DXD 2-methylcitrate dehydratase AQ16_2421 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AQ16_2424 ENOG4108Z0C Uvrb UvrC protein AQ16_244 ENOG4105W8X HesB YadR YfhF-family protein AQ16_2444 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AQ16_2446 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AQ16_2447 ENOG4105KRF dihydroneopterin aldolase AQ16_2448 ENOG4105EEI dihydropteroate synthase AQ16_2449 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 AQ16_245 ENOG4105CZM Major Facilitator AQ16_2450 ENOG4105DDQ anthranilate synthase AQ16_2451 ENOG4105CRQ synthase (Component I) AQ16_2452 ENOG4105C6T cysteine synthase AQ16_2455 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AQ16_2456 ENOG4108UGV hypoxanthine phosphoribosyltransferase AQ16_2461 ENOG41060GV RNA binding s1 domain protein AQ16_2464 ENOG4105VYY sporulation protein yabp AQ16_2465 ENOG41082I2 s4 domain protein AQ16_2466 ENOG4108IY2 MazG family AQ16_2468 ENOG4108M14 stage v sporulation protein t AQ16_2469 ENOG4108JA2 transcriptioN-repair coupling factor AQ16_247 ENOG4105BZ4 penicillin-binding protein AQ16_2472 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AQ16_2475 ENOG4105KME endoribonuclease L-psp AQ16_2476 ENOG4105DFT pur operon repressor AQ16_2479 ENOG4105W42 Veg protein AQ16_2480 ENOG4105XFA sporulation peptidase YabG AQ16_2482 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) AQ16_2483 ENOG4105F8V Hydrolase, tatD family AQ16_2484 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AQ16_2485 ENOG4105KRN Transcriptional regulator, abrb family AQ16_2486 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AQ16_2488 ENOG41060K3 Methyltransferase AQ16_2490 ENOG4105MA4 psp1 domain protein AQ16_2491 ENOG4105FA2 dna polymerase iii AQ16_2493 ENOG4105CXN decarboxylase AQ16_2501 ENOG41067KS pro-sigma K processing AQ16_2505 ENOG4105C6E dna polymerase iii AQ16_2506 ENOG4108Z6B deaminase AQ16_2507 ENOG4105GTG Isochorismatase AQ16_2509 ENOG4105ZMH deoxynucleoside kinase AQ16_251 ENOG4105CHR reductase AQ16_2516 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AQ16_2525 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AQ16_2528 ENOG410848D S4 domain protein YaaA AQ16_2529 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AQ16_2533 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AQ16_2539 ENOG4107QJE Chromosome Partitioning Protein AQ16_2540 ENOG4105FA0 parb-like partition protein AQ16_2541 ENOG4108ZDA Sporulation protein YyaC AQ16_2542 ENOG4105D8X mechanosensitive ion channel AQ16_2543 ENOG4105VDK protein, conserved in bacteria AQ16_2544 ENOG4105C3G gtp-binding protein AQ16_2546 ENOG4108UUM single-stranded DNA-binding protein AQ16_2548 ENOG4108XMW Membrane AQ16_2549 ENOG4105BZR domain protein AQ16_2551 ENOG4105CDU Replicative dna helicase AQ16_2557 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AQ16_2558 ENOG4105BZU Histidine kinase AQ16_2561 ENOG4105Q2H domain protein AQ16_2562 ENOG4105C0H protease AQ16_2567 ENOG4105DPN Oligoendopeptidase f AQ16_257 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AQ16_2570 ENOG4105C1J atp-dependent rna helicase AQ16_2572 ENOG4108UT2 hemolysin iii AQ16_2573 ENOG4105CMR udp-glucose 4-epimerase AQ16_2575 ENOG4105IW1 AmiS UreI transporter AQ16_2577 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AQ16_2580 ENOG4107RGD Major Facilitator superfamily AQ16_2581 ENOG4108HRK Histidine kinase AQ16_2582 ENOG4105DY9 regulatoR AQ16_2585 ENOG4106F5Q Membrane AQ16_2586 ENOG4105E0X reductase AQ16_2588 ENOG41067SE Tetr family transcriptional regulator AQ16_2589 ENOG4105CKK Glycosyl transferase, family 2 AQ16_2593 ENOG4105C5H ABC transporter AQ16_2594 ENOG4105JEU Glycosyl transferase, family 2 AQ16_2596 ENOG4108S4H thioesterase Superfamily protein AQ16_2598 ENOG4106YBV Methyl-accepting chemotaxis AQ16_2599 ENOG4105EN6 Membrane AQ16_26 ENOG4108VKI Cell wall hydrolase AQ16_2603 ENOG41079KZ Major Facilitator Superfamily AQ16_2604 ENOG4105DY9 regulatoR AQ16_2605 ENOG4105D22 carbon starvation protein AQ16_2606 ENOG4105VCD cytoplasmic protein AQ16_2607 ENOG4105BZU Histidine kinase AQ16_2608 ENOG4105DWF phosphomethylpyrimidine kinase AQ16_2609 ENOG4105BZU Histidine kinase AQ16_2610 ENOG4105WH1 Two component transcriptional regulator luxr family AQ16_2612 ENOG4108Y4K DNA-binding transcriptional activator AQ16_2617 ENOG4105D6E homoserine dehydrogenase AQ16_2620 ENOG41090WU lipolytic protein G-D-S-L family AQ16_2621 ENOG4105CJ1 ABC, transporter AQ16_2622 ENOG4108TU7 Inherit from COG: (ABC) transporter AQ16_2624 ENOG4105VCH membrane AQ16_2625 ENOG410667J hydrolase AQ16_2627 ENOG4107SVH Potassium channel protein AQ16_2631 ENOG4108VKI Cell wall hydrolase AQ16_2634 ENOG4108IJ2 phosphate acetyltransferase AQ16_2635 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) AQ16_2636 ENOG4108VCI transcription factor, rsfa family AQ16_2638 ENOG4105DQ5 transport system permease protein AQ16_2639 ENOG4105EHG Permease protein AQ16_264 ENOG4108AEY RNA polymerase sigma factor AQ16_2640 ENOG4105E0A ABC, transporter AQ16_2641 ENOG4108MES Periplasmic binding protein AQ16_2642 ENOG4105DCI Phosphohydrolase AQ16_2643 ENOG41069HH 4-oxalocrotonate tautomerase AQ16_2644 ENOG4108Z4T Peptidase M50 AQ16_2645 ENOG4108XFG YwhD family AQ16_2646 ENOG4105BZ4 penicillin-binding protein AQ16_2647 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AQ16_2648 ENOG4107SWG transcriptional regulator MERR family AQ16_2649 ENOG4105DXB Major Facilitator superfamily AQ16_2651 ENOG4105CYW agmatinase AQ16_2655 ENOG410684U Domain of unknown function (DUF1934) AQ16_2657 ENOG4105EMN RNA polymerase sigma factor AQ16_2662 ENOG4105IIU Aminopeptidase AQ16_2663 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) AQ16_2664 ENOG4108M15 ABC transporter AQ16_2665 ENOG4105KCT ABC transporter AQ16_2666 ENOG4105BZU Histidine kinase AQ16_2671 ENOG4105BZU Histidine kinase AQ16_2674 ENOG4105DF6 Fe-S oxidoreductase AQ16_2676 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AQ16_2677 ENOG4105C1G acyl-Coa dehydrogenase AQ16_2678 ENOG4105C1G acyl-Coa dehydrogenase AQ16_2685 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AQ16_2686 ENOG4105CBT Fructose-1,6-bisphosphatase AQ16_2687 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AQ16_2690 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AQ16_2691 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AQ16_2692 ENOG4108ZXQ stage ii sporulation protein r AQ16_2694 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AQ16_2698 ENOG4107XC4 flavin reductase domain protein, FMN-binding AQ16_2699 ENOG4108VGI doxx family AQ16_27 ENOG4105DK7 lysyl-tRNA synthetase AQ16_2702 ENOG4108YZG isomerase AQ16_2707 ENOG41062M3 atp synthase AQ16_2708 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) AQ16_2718 ENOG4105BZU Histidine kinase AQ16_2719 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AQ16_2721 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AQ16_2722 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AQ16_2727 ENOG4105D65 subunit l AQ16_2728 ENOG4105C8S subunit m AQ16_2729 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AQ16_273 ENOG4105SZ6 Thioredoxin AQ16_2730 ENOG4106778 Protein of unknown function (DUF1146) AQ16_2734 ENOG4105CEY Amp-dependent synthetase and ligase AQ16_2735 ENOG4105DY9 regulatoR AQ16_2738 ENOG4105FRN stage II sporulation protein AQ16_2739 ENOG4107BJW polysaccharide deacetylase AQ16_274 ENOG410841Q phosphoesterase PA-phosphatase related protein AQ16_2740 ENOG4105MT0 Sporulation transcriptional regulator spoiiid AQ16_2742 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase AQ16_2743 ENOG4107RZX Teichoic acid biosynthesis protein AQ16_2744 ENOG4107SJB teichoic acid biosynthesis AQ16_2745 ENOG4107SJB teichoic acid biosynthesis AQ16_2747 ENOG4105EY8 ABC transporter AQ16_2749 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AQ16_2752 ENOG4108RB3 Capsular polysaccharide biosynthesis protein AQ16_2753 ENOG4105CMR udp-glucose 4-epimerase AQ16_2754 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AQ16_2758 ENOG4105CXY transporter AQ16_2759 ENOG4105D7V transposase AQ16_276 ENOG4108N23 SpoOM-related protein AQ16_2761 ENOG4105C19 ABC transporter AQ16_2762 ENOG4107RBB ABC transporter, permease AQ16_2765 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AQ16_2771 ENOG4105C0D helicase AQ16_2772 ENOG4105KBK Zinc finger, swim domain protein AQ16_2777 ENOG41069ER domain protein AQ16_2778 ENOG4105C94 Transporter AQ16_2780 ENOG4107R8N Glycosyl transferase, family 2 AQ16_2785 ENOG4105E0M Sulfatase AQ16_2787 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) AQ16_2789 ENOG4105DAA L-lactate AQ16_2796 ENOG4107RSM transcriptional regulator AQ16_2797 ENOG4105ECB domain protein AQ16_2798 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase AQ16_2801 ENOG4105VZJ PTS System AQ16_2803 ENOG4105VCP PTS System AQ16_2805 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AQ16_2807 ENOG4105CK1 PTS System AQ16_2808 ENOG4105VCP PTS System AQ16_2809 ENOG4105F8D glycoside hydrolase family 4 AQ16_2813 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AQ16_2815 ENOG4105ESV Glycosyl transferase, family 4 AQ16_2816 ENOG4105C6Y Udp-glucose 6-dehydrogenase AQ16_2817 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AQ16_2818 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AQ16_2819 ENOG4108KGH TRANSCRIPTIONal AQ16_2820 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AQ16_2822 ENOG4105KVH Transcriptional regulator AQ16_2825 ENOG41081UC Inherit from COG: Competence protein AQ16_2826 ENOG4105VEQ Cold shock protein AQ16_2827 ENOG4105MS2 ribosomal subunit Interface protein AQ16_2829 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AQ16_2831 ENOG4105CAK Cell division ATP-binding protein ftsE AQ16_2832 ENOG4105CRP Part of the ABC transporter FtsEX involved in AQ16_2833 ENOG4105CN1 protease AQ16_2835 ENOG4105BZ1 (ABC) transporter AQ16_2837 ENOG4108WS4 fmn reductase AQ16_2839 ENOG4105DUM transcriptional regulator, lysR family AQ16_284 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AQ16_2846 ENOG4107TXC Transcriptional regulator AQ16_2849 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AQ16_285 ENOG4108JUB Transcriptional regulator AQ16_2850 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AQ16_2852 ENOG41086DT Membrane protein of unknown function AQ16_2856 ENOG4108S4C acetyltransferase AQ16_2858 ENOG4105C3M thioredoxin reductase AQ16_286 ENOG4108TSC N-acetyltransferase AQ16_2860 ENOG4108Z4K mutator MutT protein AQ16_2862 ENOG4105CHW UPF0052 protein AQ16_2864 ENOG4105KRI phosphocarrier protein (HPr AQ16_2865 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AQ16_2866 ENOG4108QY0 Membrane AQ16_2869 ENOG4105CZ3 stage V sporulation protein ad AQ16_287 ENOG4107S4Y M20 DapE family protein YgeY AQ16_2870 ENOG41090VF Stage v sporulation protein ac AQ16_2874 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AQ16_2880 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AQ16_2884 ENOG41067MG lrgb family AQ16_2885 ENOG4105XZU Preprotein translocase, subunit SecG AQ16_2887 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AQ16_2893 ENOG4105CM4 permease protein AQ16_2894 ENOG4108IPW abc transporter atp-binding protein AQ16_2899 ENOG4108MK9 spermidine N(1)-acetyltransferase AQ16_29 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein AQ16_290 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AQ16_2900 ENOG4105C5H ABC transporter AQ16_2905 ENOG4105WMR Protein CrcB homolog AQ16_2907 ENOG4105C8Q Methyl-accepting chemotaxis AQ16_2909 ENOG4105D4A Cell wall formation (By similarity) AQ16_2910 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AQ16_2914 ENOG4105KVH Transcriptional regulator AQ16_2915 ENOG4105F27 Major Facilitator AQ16_2916 ENOG4105CV8 reductase AQ16_2919 ENOG4108RYK Nad-dependent epimerase dehydratase AQ16_2922 ENOG4105D9N nucleoside AQ16_2923 ENOG4105D9N nucleoside AQ16_2927 ENOG4108URH decarboxylase AQ16_2930 ENOG4108RMU ferritin dps family protein AQ16_2932 ENOG4105NCW Trka-c domain protein AQ16_2933 ENOG4107S91 Sodium hydrogen exchanger AQ16_2934 ENOG4107T5V SNARE associated Golgi AQ16_2938 ENOG4105D4Y metalloprotease AQ16_2939 ENOG4105VG1 fes assembly suf system protein AQ16_2940 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AQ16_2941 ENOG4105C8Q Methyl-accepting chemotaxis AQ16_2945 ENOG4105BZU Histidine kinase AQ16_2946 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AQ16_2947 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AQ16_2949 ENOG4107ZTW SNARE associated Golgi AQ16_295 ENOG4105C37 (CBS) domain AQ16_2957 ENOG4107AYK membrAne AQ16_2959 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AQ16_2962 ENOG4107R7I amino acid AQ16_2963 ENOG4108SUT Major Facilitator Superfamily AQ16_2967 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AQ16_2971 ENOG4105DZ1 carboxypeptidase AQ16_2974 ENOG4105CHU acetyl-coa acetyltransferase AQ16_2975 ENOG4105C1G acyl-Coa dehydrogenase AQ16_2976 ENOG4108W8B Beta-lactamase domain protein AQ16_2986 ENOG41080E8 Transcriptional regulator, Spx MgsR family AQ16_2992 ENOG4108UMI ABC transporter, permease AQ16_2993 ENOG4105D01 (LipO)protein AQ16_2994 ENOG4105D01 (LipO)protein AQ16_2995 ENOG4105C3K feS assembly ATPase SufC AQ16_2996 ENOG4105JRK feS assembly protein SufD AQ16_2997 ENOG4105C9B Cysteine desulfurase AQ16_2998 ENOG4108UNV SUF system FeS assembly protein, NifU family AQ16_2999 ENOG4105DIW FeS assembly protein SUFB AQ16_3003 ENOG4107R8B 5'-nucleotidase AQ16_3004 ENOG4105KZD Domain of unknown function (DUF1805) AQ16_3005 ENOG4108YTE sporulation protein YunB AQ16_3006 ENOG4105FAA peptidase M23 AQ16_3011 ENOG41090T1 Membrane AQ16_3012 ENOG4107TXC Transcriptional regulator AQ16_3013 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) AQ16_3014 ENOG4105MMD transcriptional regulator AQ16_3017 ENOG4105CBT Fructose-1,6-bisphosphatase AQ16_302 ENOG4105E90 ABC transporter AQ16_3020 ENOG4105D4U had-superfamily hydrolase, subfamily iia AQ16_3022 ENOG4105DYS nad(p)h dehydrogenase (quinone) AQ16_3024 ENOG4105DAX Pfam:DUF2983 AQ16_3028 ENOG4108W5N phosphatidylglycerophosphatase a AQ16_303 ENOG4108IJ8 ABC transporter AQ16_3031 ENOG41083MR nifu domain-containing protein AQ16_3036 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AQ16_3037 ENOG4105C4B ABC transporter, permease AQ16_3038 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AQ16_3042 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AQ16_3046 ENOG4105EWC Purine nucleoside phosphorylase AQ16_3051 ENOG4105CEP NADH dehydrogenase AQ16_3054 ENOG41069ER domain protein AQ16_3058 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AQ16_3062 ENOG4105KA0 thioesterase Superfamily protein AQ16_3063 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) AQ16_3066 ENOG4107R3E Citrate transporter AQ16_3068 ENOG4105Y38 Kinase-associated protein B AQ16_3071 ENOG4105C87 Aminotransferase class I and II AQ16_3073 ENOG4108MUZ hydrolase AQ16_3074 ENOG4105C5I Dehydrogenase AQ16_3075 ENOG4108ZB6 transcriptional regulator AsnC family AQ16_3076 ENOG4105CHM Aminotransferase AQ16_3078 ENOG4105WG9 Conserved Protein AQ16_3080 ENOG4107PBV potassium channel AQ16_3082 ENOG4105KT7 mgtC SapB transporter AQ16_3090 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AQ16_31 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AQ16_3109 ENOG4105EMN RNA polymerase sigma factor AQ16_311 ENOG4105C6Z Gluconate AQ16_3111 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AQ16_3112 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AQ16_312 ENOG4105CMG Carbohydrate kinase AQ16_3123 ENOG4105VEQ Cold shock protein AQ16_3125 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AQ16_3126 ENOG4105E4F Isochorismate synthase AQ16_3128 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) AQ16_3129 ENOG4108IPT Naphthoate synthase AQ16_3131 ENOG4105DTQ mandelate racemase muconate lactonizing AQ16_3137 ENOG41069H0 dihydroorotase EC 3.5.2.3 AQ16_3141 ENOG4105FDP GntR family transcriptional regulator AQ16_3142 ENOG4105C6Z Gluconate AQ16_3152 ENOG41082BM Transcriptional regulator, arsr family AQ16_3154 ENOG41086D8 Transcriptional regulator AQ16_3155 ENOG4105C19 ABC transporter AQ16_3160 ENOG4107ZTW SNARE associated Golgi AQ16_3165 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) AQ16_3166 ENOG4108UGV hypoxanthine phosphoribosyltransferase AQ16_3171 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AQ16_3172 ENOG4105BZU Histidine kinase AQ16_3178 ENOG41087YS Phage shock protein A AQ16_3188 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AQ16_3189 ENOG4105C4M (Ubiquinol oxidase) subunit I AQ16_319 ENOG4106KNT transcriptional regulator AQ16_3191 ENOG4108V2W Carbonate dehydratase AQ16_320 ENOG4105WH1 Two component transcriptional regulator luxr family AQ16_3203 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase AQ16_3206 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component AQ16_3208 ENOG4105D2X ABC transporter substrate-binding protein AQ16_321 ENOG4105BZU Histidine kinase AQ16_3211 ENOG4107T7U Sulfatase AQ16_3212 ENOG4107S9D Alpha beta hydrolase AQ16_3213 ENOG4105BZU Histidine kinase AQ16_3214 ENOG4105BZU Histidine kinase AQ16_322 ENOG4105D8X mechanosensitive ion channel AQ16_3229 ENOG4108RIR Molybdenum cofactor biosynthesis protein AQ16_3231 ENOG4105BZF Glycosyl transferase (Group 1 AQ16_3232 ENOG4105YVM Phosphoesterase, PA-phosphatase related AQ16_3233 ENOG4108Z0R Transferase AQ16_3234 ENOG4105E8V Alpha Beta Hydrolase Fold protein AQ16_3239 ENOG4107A6P AQ16_3242 ENOG4105DA5 (ABC) transporter AQ16_3244 ENOG4105N5T Radical SAM Protein AQ16_3248 ENOG4105C19 ABC transporter AQ16_3251 ENOG4105NCW Trka-c domain protein AQ16_3252 ENOG4107S91 Sodium hydrogen exchanger AQ16_3253 ENOG410605W Major Facilitator AQ16_3259 ENOG4108B31 Spore germination protein AQ16_326 ENOG4105F0I Aminotransferase AQ16_3261 ENOG4105DWV Homoserine O-trans-acetylase AQ16_3263 ENOG41085GJ domain protein AQ16_3267 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AQ16_3268 ENOG4105D06 uba thif-type nad fad binding protein AQ16_327 ENOG4108MES Periplasmic binding protein AQ16_3270 ENOG4105CVM Molybdenum cofactor synthesis domain protein AQ16_3271 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein AQ16_3272 ENOG4108ZAF Molybdopterin AQ16_3276 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AQ16_3277 ENOG4108VJ1 Transcriptional regulator (CarD family AQ16_3284 ENOG4105CBX hi0933 family AQ16_3287 ENOG4105YW5 deoR family transcriptional regulator AQ16_3288 ENOG4107QSE Dipeptidase AQ16_3290 ENOG4108IUM Glycogen debranching enzyme AQ16_3291 ENOG4108V15 phosphotransferase enzyme family AQ16_3294 ENOG4105C8F Beta-lactamase domain protein AQ16_33 ENOG410900G Protein of unknown function (DUF421) AQ16_3300 ENOG4108VDD TRNA binding domain protein AQ16_3307 ENOG4105K7K Transcriptional regulator AQ16_3309 ENOG4108IPJ Membrane AQ16_331 ENOG4105CAQ asparagine synthetase AQ16_3314 ENOG4105C88 aminopeptidase AQ16_3318 ENOG4105ETE Transcriptional regulator (LacI family AQ16_332 ENOG4107Y70 Heat shock protein AQ16_3323 ENOG4105EP9 oxidoreductase AQ16_3324 ENOG4105DY9 regulatoR AQ16_333 ENOG4108KF3 Electron transport protein SCO1 SenC AQ16_3330 ENOG4106HB6 Alpha beta hydrolase AQ16_3331 ENOG4105DGU Histone deacetylase AQ16_3332 ENOG4105W87 Cbs domain AQ16_3333 ENOG4105F1V Acetoin utilization protein AQ16_3335 ENOG4108UW5 maltose o-acetyltransferase AQ16_334 ENOG4105E8R UPF0173 metal-dependent hydrolase AQ16_3344 ENOG4105C28 cystathionine AQ16_3346 ENOG4105U5Y Transcriptional regulator AQ16_3348 ENOG4105C5Q Transcriptional regulator AQ16_335 ENOG4108RCR degv family AQ16_3353 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AQ16_3355 ENOG4105EFZ amidohydrolase AQ16_3358 ENOG4105KBJ sporulation protein ytfj AQ16_3359 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AQ16_3365 ENOG4108JYZ YitT family AQ16_337 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AQ16_3373 ENOG4107YZX Universal stress protein AQ16_3377 ENOG4105VZ8 Transcriptional regulator AQ16_3379 ENOG41082W1 Cupin 2, conserved barrel domain protein AQ16_3380 ENOG4105Z7P Acetyltransferase (GNAT) family AQ16_3388 ENOG4105DC7 peptidase M24 AQ16_339 ENOG4108UT2 hemolysin iii AQ16_3396 ENOG4105SFS phosphoesterase RecJ domain protein AQ16_3398 ENOG4105VV2 AQ16_3399 ENOG4105C0B DNA polymerase III (alpha subunit) AQ16_340 ENOG4105E9Q Acyl-transferase AQ16_3400 ENOG4105C6K Malic enzyme AQ16_3401 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AQ16_3406 ENOG4105FS0 cytoplasmic membrane protein AQ16_3407 ENOG4108REF Sporulation integral membrane protein ytvi AQ16_3409 ENOG4105BZN citrate synthase AQ16_3410 ENOG4108HMX isocitrate dehydrogenase (NADP) AQ16_3415 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AQ16_3416 ENOG4105BZU Histidine kinase AQ16_3417 ENOG4105C2M dna polymerase I AQ16_342 ENOG4107RVG penicillin-binding protein AQ16_3420 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AQ16_3421 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AQ16_3423 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AQ16_3427 ENOG4108TDW sporulation protein YtxC AQ16_3428 ENOG4105C22 threonyL-tRNA synthetase AQ16_3429 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AQ16_3433 ENOG4105CN9 Peptidase m42 family protein AQ16_3434 ENOG4108JGH Tetr family transcriptional regulator AQ16_3435 ENOG4105CW7 secretion protein, HlyD family AQ16_3436 ENOG4105C0R drug resistance transporter emrb qaca subfamily AQ16_3440 ENOG4108RWN rrna methyltransferase AQ16_3442 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AQ16_3443 ENOG4105C5S asparaginyl-tRNA synthetase AQ16_3446 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AQ16_3449 ENOG4105DCG PHP domain protein AQ16_345 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) AQ16_3452 ENOG4105FE9 pseudouridine synthase AQ16_3454 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) AQ16_3456 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) AQ16_3459 ENOG4105E0A ABC, transporter AQ16_3460 ENOG4105KFN sortase, SrtB family AQ16_3462 ENOG4105DR4 Methyltransferase AQ16_3465 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AQ16_3475 ENOG4105CEY Amp-dependent synthetase and ligase AQ16_3476 ENOG4107Z3H Transcriptional regulator, TetR family AQ16_3477 ENOG41060WC Enoyl-CoA hydratase AQ16_3478 ENOG4105BZJ Electron transfer flavoprotein AQ16_3479 ENOG4105C10 Electron transfer flavoprotein AQ16_348 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 AQ16_3480 ENOG4105K63 Thioredoxin AQ16_3483 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit AQ16_3485 ENOG4105E33 succinate dehydrogenase AQ16_3489 ENOG4105E14 MotA TolQ exbB proton channel AQ16_3490 ENOG4105ER2 Ompa motb domain protein AQ16_3491 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family AQ16_3492 ENOG4108IUX (ABC) transporter AQ16_3493 ENOG4105RHA ABC transporter, permease AQ16_3494 ENOG4108Z40 Transcriptional regulator AQ16_3495 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AQ16_3497 ENOG4108JCI Transcriptional regulator AQ16_3498 ENOG41067S9 phage shock protein C, PspC AQ16_3499 ENOG4105DZC cytosine deaminase AQ16_3501 ENOG4105PFC Transcriptional regulator AQ16_353 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase AQ16_3535 ENOG4105KBX Transcriptional regulator, TetR family AQ16_3537 ENOG4105C0R drug resistance transporter emrb qaca subfamily AQ16_3539 ENOG4108XJQ germination protein AQ16_354 ENOG4105KD7 acetyltransferase AQ16_3542 ENOG4105M59 Phosphodiesterase, mj0936 family AQ16_3546 ENOG4108QCI YvbH-like oligomerisation region AQ16_3552 ENOG4108IUQ atp-dependent protease AQ16_3556 ENOG4105K56 Transcriptional regulator AQ16_3561 ENOG4105D52 delta-aminolevulinic acid dehydratase AQ16_3563 ENOG41068KH stage VI sporulation protein D AQ16_3566 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AQ16_357 ENOG4105C0A alcohol dehydrogenase AQ16_3570 ENOG4105DFF Rod shape-determining protein mreb AQ16_3571 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AQ16_3574 ENOG4107QMS site-determining protein AQ16_3577 ENOG4105C03 ribonuclease AQ16_3579 ENOG4105X36 (ribosomal) protein AQ16_358 ENOG4105CY2 Citrate transporter AQ16_3582 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AQ16_3584 ENOG4105EWM Histidine kinase AQ16_3585 ENOG4105C19 ABC transporter AQ16_3588 ENOG4105CQC Prephenate dehydratase AQ16_3589 ENOG4108RPX mosc domain containing protein AQ16_359 ENOG4107XGZ Hydrolase AQ16_3592 ENOG4108IYU L-aspartate oxidase AQ16_3593 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AQ16_3598 ENOG41082BM Transcriptional regulator, arsr family AQ16_3599 ENOG4108IPJ Membrane AQ16_360 ENOG4107XGZ Hydrolase AQ16_3601 ENOG4108HUF Transporter AQ16_3604 ENOG41061AI Protein of unknown function (DUF2905) AQ16_3607 ENOG4105VIE preprotein translocase, subunit YajC AQ16_3609 ENOG4108QG2 Membrane AQ16_3610 ENOG4105CKP Polysaccharide Biosynthesis Protein AQ16_3612 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AQ16_3613 ENOG41076HS cation diffusion facilitator family transporter AQ16_3614 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AQ16_3616 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AQ16_3619 ENOG4105CUT histidyl-tRNA synthetase AQ16_3621 ENOG4105CUZ uba thif-type nad fad binding protein AQ16_3622 ENOG4108VCI transcription factor, rsfa family AQ16_3623 ENOG4106F1P AAA ATPase, central domain protein AQ16_3624 ENOG4105D1H recombination factor protein RarA AQ16_3626 ENOG4105C3J Cysteine desulfurase AQ16_3629 ENOG4105C7H Helicase, RecD TraA family AQ16_3630 ENOG41060CR AQ16_3633 ENOG4105C02 permease AQ16_3639 ENOG4105HHA aminodeoxychorismate lyase AQ16_364 ENOG4105C8J )-transporter AQ16_3640 ENOG4108VQJ O-methyltransferase AQ16_3641 ENOG4105XYU peptidase (U32 family) AQ16_3642 ENOG4105CFP Peptidase U32 AQ16_3645 ENOG4107XRG penicillin-binding protein AQ16_3651 ENOG4105C28 cystathionine AQ16_3652 ENOG4108EKI Dehydrogenase AQ16_3654 ENOG4108V5C ABC transporter AQ16_3655 ENOG4105S6R Iron-hydroxamate transporter permease subunit AQ16_366 ENOG4105BZW Glycerate kinase AQ16_3663 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AQ16_3665 ENOG4105MIR Phenylalanine 4-monooxygenase AQ16_3666 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AQ16_367 ENOG4105C5S asparaginyl-tRNA synthetase AQ16_3680 ENOG4108MUZ hydrolase AQ16_3682 ENOG4105G6Z alkaline phosphatase AQ16_3685 ENOG4108TVJ Nitroreductase AQ16_3689 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AQ16_3692 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase AQ16_3693 ENOG4105CQW ribosome biogenesis GTPase YqeH AQ16_3695 ENOG410812S Rna-binding protein AQ16_3697 ENOG4108WF2 Metal Dependent Phosphohydrolase AQ16_3699 ENOG4105DXX methyltransferase AQ16_37 ENOG4105EFA 4-hydroxyphenylacetate AQ16_3701 ENOG4105KQC Competence protein AQ16_3702 ENOG4108UK2 deaminase AQ16_3703 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AQ16_3705 ENOG4105TQK DNA polymerase iii, delta' subunit AQ16_3710 ENOG4105KVH Transcriptional regulator AQ16_3711 ENOG4105CSA Coproporphyrinogen iii oxidase AQ16_3717 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AQ16_3718 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AQ16_3720 ENOG4105KTH gatB Yqey AQ16_3721 ENOG41068P3 sporulation protein YqfC AQ16_3723 ENOG4105C9A Phoh family AQ16_3724 ENOG4105CTJ Metal Dependent Phosphohydrolase AQ16_3726 ENOG4107YR5 Diacylglycerol kinase AQ16_3727 ENOG4105KG3 cytidine deaminase AQ16_3728 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AQ16_3733 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AQ16_3734 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AQ16_3737 ENOG4105EGD dinuclear metal center protein, YbgI family AQ16_374 ENOG4105C75 arginyL-tRNA synthetase AQ16_3742 ENOG41069ZM Protein of unknown function (DUF2624) AQ16_3743 ENOG4108JYZ YitT family AQ16_3744 ENOG4105FDK ABC transporter AQ16_3746 ENOG4105N80 Ferric uptake regulator, Fur family AQ16_375 ENOG4107YX5 Pfam:DUF548 AQ16_3751 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AQ16_3753 ENOG4107RF6 penicillin-binding protein AQ16_3754 ENOG4105PWN phosphate abc transporter AQ16_3755 ENOG4105C8U phosphate abc transporter AQ16_3756 ENOG4105E2Z phosphate ABC transporter (Permease AQ16_3757 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AQ16_3758 ENOG4108UTW Plays a role in the regulation of phosphate uptake AQ16_3761 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AQ16_3763 ENOG4105DKQ ROK family AQ16_3765 ENOG4105C5X domain protein AQ16_3769 ENOG4105C28 cystathionine AQ16_3770 ENOG4105C28 cystathionine AQ16_3772 ENOG4105C3R Methionine synthase AQ16_379 ENOG4108UUM single-stranded DNA-binding protein AQ16_3800 ENOG4105C0D helicase AQ16_3806 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AQ16_3807 ENOG4105CJ1 ABC, transporter AQ16_3814 ENOG41080TC multidrug resistance protein AQ16_3819 ENOG4105WZW rhodanese family AQ16_382 ENOG4105C5H ABC transporter AQ16_3820 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) AQ16_3829 ENOG4107YBY Hydrolase AQ16_3830 ENOG4105CBJ Metal-dependent enzyme AQ16_3833 ENOG4105DC7 peptidase M24 AQ16_3838 ENOG4105CD2 stage iii sporulation protein aa AQ16_3839 ENOG4105KR5 Stage iii sporulation protein AQ16_3840 ENOG4108CQH stage III sporulation protein AC AQ16_3841 ENOG4105KQ4 Stage iii sporulation protein ad AQ16_3843 ENOG410644B Stage III sporulation protein af AQ16_3848 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AQ16_3849 ENOG4108ZSR alkaline shock protein AQ16_385 ENOG4105MCT stage V sporulation protein S AQ16_3854 ENOG4105CTB Polyprenyl synthetase AQ16_3856 ENOG4105DX0 Hemolysin A AQ16_3858 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AQ16_3859 ENOG4105S1Z Stage IV sporulation protein B AQ16_3860 ENOG4107QQR Sporulation AQ16_3875 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AQ16_3877 ENOG4108JUB Transcriptional regulator AQ16_3879 ENOG4107RDP Dehydrogenase AQ16_3880 ENOG4105CKM Branched-chain carboxylic acid kinase AQ16_3883 ENOG4105CPP Dehydrogenase, E1 component AQ16_3884 ENOG4105C7S Dehydrogenase AQ16_3886 ENOG4108QY0 Membrane AQ16_3888 ENOG4105G7B Protein of unknown function (DUF2992) AQ16_3890 ENOG4108HW3 (ABC) transporter AQ16_3891 ENOG4105E5Q amino acid AbC transporter AQ16_3892 ENOG4105CDA abc transporter atp-binding protein AQ16_3893 ENOG4108QEG Membrane AQ16_3894 ENOG4108VZI ErfK ybiS ycfS ynhG family protein AQ16_3896 ENOG4105D9U N-acetyltransferase AQ16_3897 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AQ16_3899 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AQ16_3901 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic AQ16_3905 ENOG4105EJQ L-serine dehydratase AQ16_3906 ENOG4105II7 pyrroline-5-carboxylate reductase AQ16_3907 ENOG41069FQ Metallo-beta-lactamase superfamily AQ16_3908 ENOG4108IXY short-chain dehydrogenase reductase AQ16_391 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) AQ16_3919 ENOG4105CGH 5'-nucleotidase AQ16_392 ENOG4108IFG nitrite reductase, (NAD(P)H) AQ16_3920 ENOG4105DFD Na H antiporter AQ16_3922 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AQ16_3925 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AQ16_3926 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AQ16_393 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit AQ16_3931 ENOG4108R6K riboflavin synthase, subunit alpha AQ16_3932 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AQ16_3936 ENOG4108YM7 Gcn5-related n-acetyltransferase AQ16_3937 ENOG4105ETE Transcriptional regulator (LacI family AQ16_3939 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AQ16_394 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AQ16_3943 ENOG4105RHY Pfam:UPF0157 AQ16_3945 ENOG4105CPC Aldo Keto reductase AQ16_3949 ENOG4105MZ9 stage II sporulation protein m AQ16_395 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AQ16_3950 ENOG4105I3K Ferric uptake regulator, Fur family AQ16_3952 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AQ16_3957 ENOG4105D7N magnesium and cobalt transport protein CorA AQ16_396 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AQ16_3964 ENOG4105DVE abc transporter atp-binding protein AQ16_3965 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AQ16_3966 ENOG4105DZ1 carboxypeptidase AQ16_3967 ENOG41082AN stage II sporulation protein AQ16_3969 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AQ16_3970 ENOG4105C8J )-transporter AQ16_3974 ENOG41090VF Stage v sporulation protein ac AQ16_3975 ENOG4105CZ3 stage V sporulation protein ad AQ16_3977 ENOG4105G6R Stage v sporulation protein ae AQ16_3979 ENOG4105J7I hydrolase AQ16_3980 ENOG4105PTM secreted protein AQ16_3981 ENOG4107ZE5 PPIases accelerate the folding of proteins AQ16_3988 ENOG4105CE4 GlcNAc 6-P deacetylase AQ16_3990 ENOG4105FDP GntR family transcriptional regulator AQ16_3992 ENOG4105CID antiterminator AQ16_3995 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AQ16_3999 ENOG4105BZU Histidine kinase AQ16_4001 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AQ16_4009 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AQ16_4013 ENOG4105DTD Dehydrogenase AQ16_4014 ENOG4105K7K Transcriptional regulator AQ16_402 ENOG4108ZAF Molybdopterin AQ16_4021 ENOG4105CHU acetyl-coa acetyltransferase AQ16_4022 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AQ16_403 ENOG4105CVM Molybdenum cofactor synthesis domain protein AQ16_4030 ENOG4105CG3 alpha amylase, catalytic region AQ16_4032 ENOG4107FKK extracellular solute-binding protein family 1 AQ16_4034 ENOG4105EG2 ABC transporter, permease AQ16_4035 ENOG4105FKQ transcriptional regulator AQ16_4036 ENOG4105CHM Aminotransferase AQ16_4038 ENOG4108HGU Histidine kinase AQ16_404 ENOG4105D06 uba thif-type nad fad binding protein AQ16_405 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AQ16_4054 ENOG4105UIN AQ16_4056 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AQ16_4059 ENOG4105K6S Short-chain dehydrogenase reductase Sdr AQ16_406 ENOG4107V6Q Cyclic nucleotide-binding domain AQ16_4060 ENOG4105EPM Diguanylate phosphodiesterase AQ16_4063 ENOG4107IN1 Protein of unknown function (DUF1797) AQ16_4065 ENOG4108XRC Protein of unknown function (DUF458) AQ16_4072 ENOG4107ZYR domain protein AQ16_4073 ENOG4105CN5 Metallo-Beta-Lactamase AQ16_4075 ENOG4108X4Q Hydrolase AQ16_4076 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AQ16_4079 ENOG4105CPP Dehydrogenase, E1 component AQ16_408 ENOG4105CZV ABC transporter AQ16_4089 ENOG4105CXN decarboxylase AQ16_4093 ENOG4105ECY inositol monophosphatase AQ16_4095 ENOG4105CI3 gtp-binding protein typa AQ16_4096 ENOG4105QA2 AQ16_4100 ENOG4108IAB Phoh family AQ16_4103 ENOG4105CNI cell division protein FtsW AQ16_4104 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) AQ16_4113 ENOG4106UY4 Inherit from COG: Scp-like extracellular AQ16_4116 ENOG4107TB6 phosphoglycerate mutase AQ16_412 ENOG4105R3A Nitrate reductase AQ16_4120 ENOG4106H78 methyltransferase AQ16_4121 ENOG4105H20 Sporulation integral membrane protein YlbJ AQ16_4123 ENOG4105D78 K07001 NTE family protein AQ16_4124 ENOG41063PX domain protein AQ16_4126 ENOG4105KNH Nucleic acid-binding protein AQ16_413 ENOG4108IUE nitrate reductase beta subunit AQ16_4133 ENOG41068DC Essential cell division protein (By similarity) AQ16_4134 ENOG4105CJN penicillin-binding protein AQ16_4135 ENOG4105CJN penicillin-binding protein AQ16_4136 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AQ16_4139 ENOG4105CNI cell division protein FtsW AQ16_4140 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AQ16_4142 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) AQ16_4143 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AQ16_4144 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AQ16_4146 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AQ16_4148 ENOG4105WR5 sporulation protein, YlmC YmxH family AQ16_4149 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AQ16_415 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AQ16_4150 ENOG4105DFA alanine racemase domain protein AQ16_4152 ENOG41067XK integral membrane protein AQ16_4153 ENOG4105DBK s4 domain protein AQ16_4158 ENOG4105C34 Pseudouridine synthase AQ16_4173 ENOG4105DC7 peptidase M24 AQ16_4175 ENOG4105F23 Fibronectin-binding protein AQ16_4177 ENOG4105DSJ YicC domain protein AQ16_418 ENOG4108V06 Glutathione peroxidase AQ16_4181 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AQ16_4182 ENOG4105C25 Primosomal protein n' AQ16_4183 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AQ16_4185 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AQ16_4187 ENOG4108ZF3 Phosphatase AQ16_4188 ENOG4105D9P serine threonine protein kinase AQ16_4190 ENOG4105DJV ribulose-phosphate 3-epimerase AQ16_4191 ENOG4105FJ0 thiamine AQ16_4193 ENOG4108ZAA Alkaline-shock protein AQ16_4194 ENOG4105DP4 dak2 domain fusion protein ylov AQ16_4195 ENOG4105CB5 ATP-dependent DNA helicase recG AQ16_4198 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AQ16_4199 ENOG4105CHR reductase AQ16_4202 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AQ16_4203 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AQ16_4207 ENOG4105VB6 UPF0109 protein AQ16_4212 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AQ16_4215 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AQ16_4216 ENOG4105C79 DNA protecting protein DprA AQ16_4217 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AQ16_4219 ENOG4108HE4 integrase family AQ16_422 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) AQ16_4228 ENOG4105KNE Phosphatidate cytidylyltransferase AQ16_4230 ENOG4105DZP Membrane-associated zinc metalloprotease AQ16_4232 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AQ16_4234 ENOG4105CHV Transcription elongation factor NusA AQ16_4235 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination AQ16_4236 ENOG4105VHM ribosomal protein AQ16_4238 ENOG4105W7A Protein of unknown function (DUF503) AQ16_4241 ENOG4105DTN riboflavin biosynthesis protein ribF AQ16_4245 ENOG4105C1V Peptidase, M16 AQ16_4247 ENOG4105E35 Dipicolinate synthase subunit A AQ16_4248 ENOG4108S0H Dipicolinic acid synthetase, b subunit AQ16_425 ENOG4105EMN RNA polymerase sigma factor AQ16_4257 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AQ16_4259 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AQ16_426 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AQ16_4261 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit AQ16_4263 ENOG4107QZI cell division protein FtsK AQ16_4264 ENOG4105FDP GntR family transcriptional regulator AQ16_4265 ENOG4105DIH basic membrane AQ16_4266 ENOG4108JQ9 ABC transporter AQ16_4267 ENOG4105UIB (ABC) transporter AQ16_4271 ENOG4108RKS Short-chain dehydrogenase reductase Sdr AQ16_4272 ENOG4105XZV Protein of unknown function (DUF3243) AQ16_4275 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AQ16_4279 ENOG4105D48 metallophosphoesterase AQ16_428 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily AQ16_4280 ENOG4105MCT stage V sporulation protein S AQ16_4281 ENOG4108IGT Dipeptidase AQ16_4282 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein AQ16_4283 ENOG4105DQU oxidoreductase, subunit beta AQ16_4290 ENOG4105DA5 (ABC) transporter AQ16_4295 ENOG4107QHE Choloylglycine hydrolase AQ16_4297 ENOG410890F Dynamin family AQ16_4298 ENOG4105E0M Sulfatase AQ16_43 ENOG4105CUV Homoserine Kinase AQ16_4300 ENOG4105F0V Cell wall hydrolase AQ16_4304 ENOG4105CS2 ec 3.2.1.21 AQ16_4305 ENOG4108S3Y transcriptional regulator AQ16_4307 ENOG4107YEI lmbE family AQ16_4308 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AQ16_4311 ENOG41067MG lrgb family AQ16_4313 ENOG4107ZY0 Phenazine biosynthesis-like protein AQ16_4319 ENOG4105BZU Histidine kinase AQ16_432 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AQ16_4325 ENOG4105D03 DNA-3-methyladenine glycosylase II AQ16_4326 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AQ16_4328 ENOG4105CGK Exodeoxyribonuclease III AQ16_4332 ENOG4105E0A ABC, transporter AQ16_4333 ENOG4105NIV Esterase AQ16_4335 ENOG4105VPX protein, conserved in bacteria AQ16_4336 ENOG410681U heavy metal transport detoxification protein AQ16_4337 ENOG4105C59 p-type ATPase AQ16_4339 ENOG4105K70 DNA-binding protein AQ16_4340 ENOG4105TMB Formate nitrite transporter AQ16_4343 ENOG4105C85 amino acid AQ16_4346 ENOG4108SJC Membrane AQ16_4347 ENOG4107QW4 alcohol dehydrogenase AQ16_4348 ENOG4105E98 transcriptional regulator DeoR family AQ16_4349 ENOG4105DE4 1-phosphofructokinase AQ16_4350 ENOG4105DM4 PTS System AQ16_4351 ENOG41069ER domain protein AQ16_4356 ENOG4105DQ6 Transposase AQ16_4361 ENOG4106F1P AAA ATPase, central domain protein AQ16_4363 ENOG4105EN6 Membrane AQ16_4364 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AQ16_4365 ENOG4105CXI aluminum resistance protein AQ16_4366 ENOG4105KV4 Transcriptional regulator AQ16_4367 ENOG4105C5F glutamine synthetase AQ16_437 ENOG4105KBJ sporulation protein ytfj AQ16_4373 ENOG4105K7K Transcriptional regulator AQ16_4377 ENOG4108SVB resolvase AQ16_4379 ENOG4105CGH 5'-nucleotidase AQ16_4380 ENOG4108HW3 (ABC) transporter AQ16_4387 ENOG4105BZ1 (ABC) transporter AQ16_4388 ENOG4105BZ1 (ABC) transporter AQ16_4391 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AQ16_4396 ENOG41067MG lrgb family AQ16_4397 ENOG4105VAW lrga family AQ16_4398 ENOG4107RSM transcriptional regulator AQ16_4400 ENOG4105CJ1 ABC, transporter AQ16_4402 ENOG4105CH2 amidohydrolase AQ16_4404 ENOG4107QIV Cytochrome c biogenesis protein AQ16_4412 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AQ16_4417 ENOG4108903 Formimidoylglutamase AQ16_4418 ENOG4108VJ1 Transcriptional regulator (CarD family AQ16_4419 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AQ16_4420 ENOG4105CBC glutamate synthase AQ16_4422 ENOG4105CK7 Sodium proline symporter AQ16_4423 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase AQ16_4424 ENOG4105FBA Phospholipase Carboxylesterase AQ16_4425 ENOG4105BZU Histidine kinase AQ16_4427 ENOG4107AYK membrAne AQ16_4435 ENOG4108IMY Transcriptional regulator AQ16_4438 ENOG4105CEY Amp-dependent synthetase and ligase AQ16_4439 ENOG4107ZYJ bioY protein AQ16_444 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AQ16_4440 ENOG4107F3J Amp-dependent synthetase and ligase AQ16_4444 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AQ16_4446 ENOG4105E5W Transporter AQ16_4452 ENOG4108I0Z Aconitate hydratase AQ16_4453 ENOG4108JJA ABC, transporter AQ16_4455 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AQ16_4456 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AQ16_4462 ENOG4105W8X HesB YadR YfhF-family protein AQ16_4464 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase AQ16_4465 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) AQ16_4466 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AQ16_4467 ENOG4105C0H protease AQ16_4468 ENOG4105K4P CoA-binding domain protein AQ16_4469 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AQ16_4471 ENOG4105D9R oxidoreductase AQ16_4475 ENOG4105CIG ABC transporter AQ16_4478 ENOG4105EMN RNA polymerase sigma factor AQ16_4480 ENOG4108KGH TRANSCRIPTIONal AQ16_4484 ENOG4105CUZ uba thif-type nad fad binding protein AQ16_4493 ENOG4105CUB amino acid AQ16_4496 ENOG4105E1K spore germination protein AQ16_4497 ENOG4108JB9 formate dehydrogenase AQ16_4499 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) AQ16_450 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AQ16_4500 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AQ16_4502 ENOG4105TMB Formate nitrite transporter AQ16_4503 ENOG4105D06 uba thif-type nad fad binding protein AQ16_4504 ENOG4105CVM Molybdenum cofactor synthesis domain protein AQ16_4505 ENOG4108ZAF Molybdopterin AQ16_4507 ENOG4105D1F ATP-binding protein AQ16_451 ENOG4108JYZ YitT family AQ16_4510 ENOG410696E Membrane AQ16_4511 ENOG4105FR1 rard protein AQ16_4513 ENOG4105EWU Squalene--hopene cyclase AQ16_4515 ENOG4105CHR reductase AQ16_4516 ENOG4105C26 Dehydrogenase AQ16_4518 ENOG4108IA2 Sodium pantothenate symporter AQ16_452 ENOG41087PP glycosyltransferase MGT family AQ16_4521 ENOG4106IQC argininosuccinate lyase AQ16_4523 ENOG410904N short-chain dehydrogenase reductase AQ16_4526 ENOG4105M6F mutator MutT protein AQ16_4530 ENOG4105VEQ Cold shock protein AQ16_4533 ENOG4108R1P AQ16_4535 ENOG41073R8 VanW family AQ16_4536 ENOG4108HW4 amino acid AbC transporter AQ16_4538 ENOG4105EAB amino acid AbC transporter AQ16_4539 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AQ16_4541 ENOG4105D06 uba thif-type nad fad binding protein AQ16_4542 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AQ16_4545 ENOG4105KT7 mgtC SapB transporter AQ16_4548 ENOG4105BZU Histidine kinase AQ16_4553 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity AQ16_4554 ENOG41067SE Tetr family transcriptional regulator AQ16_4557 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) AQ16_456 ENOG4107RBS Methyltransferase AQ16_4561 ENOG4105CQB FAD linked oxidase domain protein AQ16_4562 ENOG4105C09 Bile acid AQ16_4566 ENOG410780I phosphoprotein phosphatase activity AQ16_4569 ENOG4105CB2 alcohol dehydrogenase AQ16_457 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AQ16_4570 ENOG41082BM Transcriptional regulator, arsr family AQ16_4572 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AQ16_4578 ENOG4108A04 Beta-lactamase AQ16_4585 ENOG4105DPN Oligoendopeptidase f AQ16_4586 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AQ16_4587 ENOG4105E5K Alpha-amylase AQ16_4589 ENOG4105C98 muts2 protein AQ16_459 ENOG4108X4Q Hydrolase AQ16_4593 ENOG4107V2S Transcriptional regulator AQ16_4595 ENOG4107CUJ Protein of unknown function (DUF2690) AQ16_4600 ENOG4105NX3 Membrane AQ16_4601 ENOG4105DQ5 transport system permease protein AQ16_4602 ENOG4105EHG Permease protein AQ16_4603 ENOG4108MES Periplasmic binding protein AQ16_4606 ENOG4107R3E Citrate transporter AQ16_4608 ENOG4108TN2 lmbE family AQ16_4613 ENOG4105CIS alcohol dehydrogenase AQ16_4614 ENOG4105K7K Transcriptional regulator AQ16_4624 ENOG4105H3G oxidoreductase AQ16_4629 ENOG410751J AQ16_4633 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) AQ16_4638 ENOG4105KAF membrAne AQ16_4646 ENOG4108ZJ4 polysaccharide deacetylase AQ16_4651 ENOG4105KVH Transcriptional regulator AQ16_4652 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AQ16_4654 ENOG4105KNA -acetyltransferase AQ16_4656 ENOG4105CHR reductase AQ16_4658 ENOG4105JAB phenazine biosynthesis protein, phzf family AQ16_4665 ENOG4105D9R oxidoreductase AQ16_4666 ENOG4108TZY GntR Family Transcriptional Regulator AQ16_467 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AQ16_4671 ENOG4105C44 Serine transporter AQ16_4678 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AQ16_4681 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AQ16_4682 ENOG4105C6Z Gluconate AQ16_4683 ENOG4105CMG Carbohydrate kinase AQ16_4684 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AQ16_4685 ENOG4105XDF Protein of unknown function (DUF1272) AQ16_4686 ENOG4105DDN Pentapeptide repeat-containing protein AQ16_469 ENOG4108VXD carboxy-peptidase AQ16_4691 ENOG4105FAW cDP-glucose 4,6-dehydratase AQ16_4692 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase AQ16_4695 ENOG4105C37 (CBS) domain AQ16_47 ENOG41089UC methyltransferase, type 11 AQ16_4701 ENOG4105EV4 Multidrug resistance protein mdtH AQ16_4703 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) AQ16_471 ENOG4108ZRV stage ii sporulation protein p AQ16_4711 ENOG4105C31 Tryptophanyl-tRNA synthetase AQ16_4713 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AQ16_4715 ENOG4108UW5 maltose o-acetyltransferase AQ16_4716 ENOG4105DKQ ROK family AQ16_4717 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase AQ16_4729 ENOG4105CJ1 ABC, transporter AQ16_4731 ENOG4108PSK reductase AQ16_4735 ENOG4105CA9 Pyruvate kinase AQ16_4737 ENOG4108RCM Nitroreductase AQ16_4738 ENOG4105KVH Transcriptional regulator AQ16_474 ENOG4108Z7R Chaperone CsaA AQ16_4742 ENOG4108Z66 YbaK ebsC protein AQ16_4748 ENOG4107TXC Transcriptional regulator AQ16_4750 ENOG4108IND Tetr family transcriptional regulator AQ16_4751 ENOG4105EQ0 Major Facilitator superfamily AQ16_4752 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AQ16_4754 ENOG4108K8S endonuclease I AQ16_4759 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AQ16_4766 ENOG4105DYS nad(p)h dehydrogenase (quinone) AQ16_4768 ENOG4105CRW Short chain fatty acid transporter AQ16_4770 ENOG4105KBX Transcriptional regulator, TetR family AQ16_4771 ENOG4105KPY Small multidrug resistance protein AQ16_4772 ENOG4105RXJ AQ16_4774 ENOG41069JR AQ16_4775 ENOG4105DA5 (ABC) transporter AQ16_4779 ENOG4105CZM Major Facilitator AQ16_478 ENOG4105C37 (CBS) domain AQ16_4780 ENOG4107MII Sugar-specific transcriptional regulator TrmB AQ16_4783 ENOG4108ISG Major Facilitator AQ16_4786 ENOG4105PNM synthesis protein AQ16_4787 ENOG4108VXD carboxy-peptidase AQ16_479 ENOG4105SXS Protein of unknown function (DUF456) AQ16_4794 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AQ16_4804 ENOG4108JQ1 Dehydrogenase AQ16_4808 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AQ16_4811 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AQ16_4813 ENOG4105BZU Histidine kinase AQ16_4816 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) AQ16_4820 ENOG4105JQZ Methyltransferase AQ16_4824 ENOG4105VZ8 Transcriptional regulator AQ16_4829 ENOG4105K6H D-cysteine desulfhydrase AQ16_483 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AQ16_4835 ENOG41062D9 Histidine kinase AQ16_4836 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AQ16_484 ENOG4108S4H thioesterase Superfamily protein AQ16_4842 ENOG4105C0R drug resistance transporter emrb qaca subfamily AQ16_4843 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AQ16_4845 ENOG4105DMQ Methyltransferase AQ16_4854 ENOG4108YXU transcriptional regulator AsnC family AQ16_4855 ENOG4105CHR reductase AQ16_4856 ENOG4105M4P Tetr family transcriptional regulator AQ16_4857 ENOG4105F27 Major Facilitator AQ16_4858 ENOG4108IG5 Transcriptional regulator AQ16_486 ENOG4108PJD permease AQ16_4866 ENOG41085FC arsR family transcriptional regulator AQ16_4867 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase AQ16_4868 ENOG4105D6J arsenicaL-resistance protein AQ16_4871 ENOG4105Z7P Acetyltransferase (GNAT) family AQ16_4874 ENOG4105ECQ AraC Family Transcriptional Regulator AQ16_4875 ENOG4108NEV two component transcriptional regulator, LytTR family AQ16_4876 ENOG4105BZU Histidine kinase AQ16_4878 ENOG4105C19 ABC transporter AQ16_4880 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AQ16_4884 ENOG4106P55 Transcriptional regulator AQ16_4885 ENOG4107SHS Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites (By similarity) AQ16_4887 ENOG4105C0R drug resistance transporter emrb qaca subfamily AQ16_4888 ENOG4105GPN Uncharacterized conserved protein (DUF2294) AQ16_4889 ENOG4108TWJ NADH dehydrogenase subunit 5 AQ16_489 ENOG4107T5V SNARE associated Golgi AQ16_4892 ENOG4105F2M alpha beta hydrolase fold-3 domain protein AQ16_4896 ENOG4105CVP deoxyribo-dipyrimidine photolyase AQ16_4897 ENOG4108606 TspO/MBR family AQ16_49 ENOG4107Y80 Major Facilitator superfamily AQ16_4911 ENOG4105CHJ isochorismatase hydrolase AQ16_4913 ENOG4105CGH 5'-nucleotidase AQ16_4920 ENOG4105CSV Glutaminase AQ16_4924 ENOG4108Q8B Spore germination protein AQ16_4925 ENOG4108NHD germination protein AQ16_4926 ENOG4105II7 pyrroline-5-carboxylate reductase AQ16_4927 ENOG4105CUB amino acid AQ16_4928 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AQ16_4929 ENOG41075H3 AraC family transcriptional regulator AQ16_493 ENOG4105CVJ phosphoglycerate mutase AQ16_4934 ENOG4105BZU Histidine kinase AQ16_4936 ENOG4108B31 Spore germination protein AQ16_4938 ENOG4108IMY Transcriptional regulator AQ16_4939 ENOG4105HDK L-asparaginase AQ16_4940 ENOG4108IJ0 Aspartate ammonia-lyase AQ16_4942 ENOG4105E2A Dehydrogenase AQ16_4948 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AQ16_4955 ENOG4105DWD nucleoside recognition domain protein AQ16_4959 ENOG4105FDT acyl-CoA dehydrogenase AQ16_4961 ENOG4108ZHR arsR family transcriptional regulator AQ16_4962 ENOG4108ZRV stage ii sporulation protein p AQ16_4963 ENOG4106N3A copper homeostasis protein cutc AQ16_4965 ENOG4107258 Transcriptional regulator AQ16_4966 ENOG4105P4J Allophanate hydrolase, subunit 1 AQ16_4973 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AQ16_4975 ENOG4107RF6 penicillin-binding protein AQ16_498 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AQ16_4982 ENOG4105F1N DNA alkylation repair AQ16_4984 ENOG4108IQI permease AQ16_4986 ENOG410635A Membrane AQ16_4998 ENOG4108XET gCN5-related N-acetyltransferase AQ16_4999 ENOG4108DMH HTH_ARAC AQ16_500 ENOG4105K4T epimerase AQ16_5004 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AQ16_5008 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AQ16_5011 ENOG4105FS7 Transcriptional regulator AQ16_5012 ENOG4108TVJ Nitroreductase AQ16_5016 ENOG4105CHH sulfate transporter AQ16_5017 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AQ16_5019 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AQ16_502 ENOG4105DSE periplasmic solute binding protein AQ16_5027 ENOG4105C8Y Acetylornithine aminotransferase AQ16_5031 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AQ16_5036 ENOG41068WN AQ16_504 ENOG4105CKI cobalamin synthesis protein AQ16_5041 ENOG41090T1 Membrane AQ16_5044 ENOG4105VMP Transcriptional regulator AQ16_5046 ENOG4105G6Z alkaline phosphatase AQ16_5048 ENOG4105ECK Fatty Acid Desaturase AQ16_5049 ENOG4105E0Y RtcB Protein AQ16_505 ENOG4107QM2 Aldo Keto reductase AQ16_5051 ENOG4107258 Transcriptional regulator AQ16_5053 ENOG4105II7 pyrroline-5-carboxylate reductase AQ16_506 ENOG4105VMI -acetyltransferase AQ16_5060 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) AQ16_5065 ENOG41061GT Aldolase AQ16_5067 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) AQ16_5068 ENOG4105DKT Transcriptional regulator AQ16_5071 ENOG4105F5R ABC transporter AQ16_5072 ENOG4105D4B ABC, transporter AQ16_5075 ENOG41069ER domain protein AQ16_5083 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AQ16_5089 ENOG41082JN Transcriptional regulator AQ16_509 ENOG4105DEN Luciferase family AQ16_5090 ENOG4105EYF MMPL domain protein AQ16_5099 ENOG4105C5H ABC transporter AQ16_5100 ENOG4105E0M Sulfatase AQ16_5101 ENOG4108ZCF integral membrane protein AQ16_5102 ENOG4106ETB IIa component AQ16_5104 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC AQ16_5106 ENOG4107VMI polysaccharide deacetylase AQ16_5107 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase AQ16_5112 ENOG4105I4A GCN5-related N-acetyltransferase AQ16_5118 ENOG4108AQF aminoglycoside N(3)-acetyltransferase AQ16_512 ENOG4108WPJ Ferritin-like domain AQ16_5122 ENOG4105E09 nadh pyrophosphatase AQ16_5125 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein AQ16_5126 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AQ16_5127 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AQ16_5129 ENOG4105C02 permease AQ16_513 ENOG4108K88 Membrane AQ16_5140 ENOG4105DVE abc transporter atp-binding protein AQ16_5143 ENOG4108ZMI UPF0477 protein AQ16_5146 ENOG4105CHM Aminotransferase AQ16_5153 ENOG41089UC methyltransferase, type 11 AQ16_5156 ENOG4107BMA Transglycosylase associated protein AQ16_5161 ENOG4106K7D Major facilitator family transporter AQ16_5162 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AQ16_5177 ENOG4105EPR degv family AQ16_5180 ENOG4105DVH amino acid AQ16_5181 ENOG4105DPN Oligoendopeptidase f AQ16_5185 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 AQ16_5190 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AQ16_5191 ENOG4105BZU Histidine kinase AQ16_5192 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) AQ16_5202 ENOG4105DTQ mandelate racemase muconate lactonizing AQ16_5208 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AQ16_521 ENOG4107XZQ multidrug resistance protein AQ16_5211 ENOG4107T5V SNARE associated Golgi AQ16_5217 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein AQ16_5219 ENOG41080HI glycine oxidase AQ16_522 ENOG4107SET aldo keto reductase AQ16_5220 ENOG4105CTU Proline racemase AQ16_5221 ENOG4105CTU Proline racemase AQ16_5222 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AQ16_5223 ENOG4105C26 Dehydrogenase AQ16_5224 ENOG4105BZG amino acid carrier protein AQ16_5228 ENOG4108M1A Chitin-binding protein AQ16_523 ENOG4105YVS arsR family transcriptional regulator AQ16_5238 ENOG4105C9U ATP-dependent DNA helicase RecQ AQ16_524 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase AQ16_5242 ENOG4105EEM helicase AQ16_5246 ENOG4108Z7F N-acetyltransferase AQ16_5251 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AQ16_5253 ENOG4105MSB protein, conserved in bacteria AQ16_5254 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AQ16_5258 ENOG41087PP glycosyltransferase MGT family AQ16_5259 ENOG4108M1A Chitin-binding protein AQ16_526 ENOG4105KRN Transcriptional regulator, abrb family AQ16_5260 ENOG41082BV acetyltransferase AQ16_5261 ENOG4105E66 phosphoriboisomerase A AQ16_5266 ENOG4108IJ7 Glycine betaine AQ16_5267 ENOG4107SQ8 Glycine betaine AQ16_5273 ENOG4105DBI uridine monophosphokinase AQ16_5274 ENOG4105RHY Pfam:UPF0157 AQ16_5275 ENOG4105E1F short-chain dehydrogenase reductase AQ16_5277 ENOG4107RUY (E1 component), alpha subunit AQ16_5279 ENOG4107QKR Dehydrogenase AQ16_5283 ENOG4105E98 transcriptional regulator DeoR family AQ16_5287 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AQ16_5291 ENOG4107Z3H Transcriptional regulator, TetR family AQ16_5299 ENOG4105MSI germination protein ypeb AQ16_5310 ENOG4105CIS alcohol dehydrogenase AQ16_5312 ENOG4105FDR Membrane AQ16_5314 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AQ16_5315 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) AQ16_5318 ENOG4108IUM Glycogen debranching enzyme AQ16_5322 ENOG4105U0R haloacid dehalogenase-like hydrolase AQ16_5327 ENOG4107VFR oxidoreductase AQ16_5334 ENOG4107Y9U Membrane AQ16_5338 ENOG4105EGD dinuclear metal center protein, YbgI family AQ16_5343 ENOG4105FCD Major Facilitator AQ16_5346 ENOG4105E09 nadh pyrophosphatase AQ16_5347 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AQ16_5348 ENOG4108Z4K mutator MutT protein AQ16_5352 ENOG4108XI2 Domain of unknown function (DUF1963) AQ16_5356 ENOG4108NRW Phospholipase, patatin family AQ16_5357 ENOG4105KWG Pfam:DUF1696 AQ16_536 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AQ16_5364 ENOG4105PKS Excinuclease abc c subunit domain protein AQ16_537 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AQ16_5373 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AQ16_5380 ENOG4105F27 Major Facilitator AQ16_5383 ENOG4108V4B ThiJ pfpI AQ16_539 ENOG4105YWU small acid-soluble spore protein AQ16_5390 ENOG4105CJN penicillin-binding protein AQ16_5391 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AQ16_5392 ENOG4105CB2 alcohol dehydrogenase AQ16_5393 ENOG4105GR3 Histidine kinase AQ16_5396 ENOG4105RHY Pfam:UPF0157 AQ16_5398 ENOG4108HGU Histidine kinase AQ16_540 ENOG4108WBH protein TIM barrel AQ16_5405 ENOG4105BZU Histidine kinase AQ16_5406 ENOG410667J hydrolase AQ16_5414 ENOG4105K64 Glycosyl transferase, family 2 AQ16_5419 ENOG4105DQ6 Transposase AQ16_5428 ENOG4105C6E dna polymerase iii AQ16_5429 ENOG4105D7V transposase AQ16_543 ENOG4105CEY Amp-dependent synthetase and ligase AQ16_5433 ENOG4105K5B UPF0225 protein AQ16_544 ENOG4105DUU IucA IucC family protein AQ16_5447 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AQ16_5459 ENOG4105C5X domain protein AQ16_546 ENOG4105VRR gCN5-related N-acetyltransferase AQ16_5465 ENOG4105D7V transposase AQ16_5469 ENOG41067SE Tetr family transcriptional regulator AQ16_547 ENOG4105KT7 mgtC SapB transporter AQ16_5472 ENOG4105K4H Nlp p60 protein AQ16_5482 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AQ16_5484 ENOG4105CMG Carbohydrate kinase AQ16_549 ENOG4107VMI polysaccharide deacetylase AQ16_5499 ENOG4105D7V transposase AQ16_550 ENOG4105BZU Histidine kinase AQ16_5501 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AQ16_5506 ENOG4105EKQ RNA-directed DNA polymerase AQ16_551 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AQ16_5525 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AQ16_553 ENOG4108KGH TRANSCRIPTIONal AQ16_5536 ENOG4105YWU small acid-soluble spore protein AQ16_5557 ENOG4105CXY transporter AQ16_5559 ENOG4105C19 ABC transporter AQ16_5560 ENOG4107RBB ABC transporter, permease AQ16_5563 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AQ16_5567 ENOG4105C0H protease AQ16_558 ENOG4105D6E homoserine dehydrogenase AQ16_5584 ENOG4105DQ6 Transposase AQ16_5593 ENOG4105C0H protease AQ16_5597 ENOG4105C6T cysteine synthase AQ16_56 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AQ16_5601 ENOG4105DQ6 Transposase AQ16_5605 ENOG4105F32 YngK protein AQ16_5613 ENOG4105F0R Cytidylyltransferase AQ16_5614 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase AQ16_5615 ENOG4105D2T synthase AQ16_5616 ENOG4105D3Q Sugar transferase AQ16_5617 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AQ16_5619 ENOG4107YJ4 chain length determinant protein AQ16_562 ENOG4108ZJ4 polysaccharide deacetylase AQ16_5620 ENOG4105HTX biosynthesis protein AQ16_5622 ENOG4108KGH TRANSCRIPTIONal AQ16_5627 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family AQ16_563 ENOG41075D4 Aminoglycoside 6-adenylyltransferase AQ16_5669 ENOG4105DHF Membrane AQ16_5674 ENOG4106AKK s-layer domain-containing protein AQ16_5675 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AQ16_5678 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AQ16_5679 ENOG4105C6Y Udp-glucose 6-dehydrogenase AQ16_5681 ENOG4105DQ6 Transposase AQ16_570 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AQ16_5714 ENOG4105KRN Transcriptional regulator, abrb family AQ16_5716 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AQ16_572 ENOG4105BZU Histidine kinase AQ16_5724 ENOG4108IBT Inherit from COG: transposase AQ16_5726 ENOG4105DQ6 Transposase AQ16_5728 ENOG4105DQ6 Transposase AQ16_573 ENOG4105EFI regulatoR AQ16_5732 ENOG4108MEK Metal-binding protein YodA AQ16_5734 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) AQ16_574 ENOG4105BZ1 (ABC) transporter AQ16_5741 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AQ16_5759 ENOG4105EKQ RNA-directed DNA polymerase AQ16_5779 ENOG4105EKQ RNA-directed DNA polymerase AQ16_5789 ENOG4106JUT Streptomycin 3''-adenylyltransferase AQ16_58 ENOG4105T9C HD domain AQ16_5814 ENOG4105CNU cell division protein FtsK AQ16_583 ENOG4108UT6 Transferase hexapeptide repeat containing protein AQ16_5846 ENOG4107QJE Chromosome Partitioning Protein AQ16_585 ENOG4105K64 Glycosyl transferase, family 2 AQ16_5853 ENOG4108IMY Transcriptional regulator AQ16_5861 ENOG4105D7V transposase AQ16_587 ENOG4108JJ8 (ABC) transporter AQ16_5871 ENOG4106CVF DNA replication protein AQ16_588 ENOG4108JJ9 ABC, transporter AQ16_589 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AQ16_5898 ENOG4108TFU terminase (Small subunit) AQ16_590 ENOG4105C4M (Ubiquinol oxidase) subunit I AQ16_594 ENOG41090U3 tautomerase AQ16_596 ENOG4105SKE transcriptional Regulator LysR family AQ16_598 ENOG4105C32 Amino acid ABC transporter (Permease) AQ16_599 ENOG4108IV0 ABC, transporter AQ16_600 ENOG4105C0Z ABC transporter AQ16_603 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AQ16_604 ENOG4108Z7G MaoC domain protein dehydratase AQ16_607 ENOG4105CKI cobalamin synthesis protein AQ16_609 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AQ16_610 ENOG4106F5Q Membrane AQ16_614 ENOG4108TVJ Nitroreductase AQ16_615 ENOG4107ZXU DSBA oxidoreductase AQ16_616 ENOG4108Z40 Transcriptional regulator AQ16_617 ENOG4105GZI Transcriptional regulator AQ16_618 ENOG4107RT3 EamA-like transporter family AQ16_619 ENOG4105KTB nuclear export factor GLE1 AQ16_620 ENOG4108T5E Copper resistance protein AQ16_626 ENOG4105D7V transposase AQ16_627 ENOG4105CAQ asparagine synthetase AQ16_628 ENOG4105DND Transcriptional regulator AQ16_637 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AQ16_64 ENOG4105DBI uridine monophosphokinase AQ16_641 ENOG4107R16 Multicopper oxidase AQ16_642 ENOG4107RAQ aminopeptidase AQ16_650 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AQ16_651 ENOG4105D9N nucleoside AQ16_653 ENOG4107RHR regulatoR AQ16_656 ENOG4105K8R UPF0145 protein AQ16_661 ENOG4105C0X amino acid AQ16_663 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AQ16_666 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) AQ16_670 ENOG41068WN AQ16_675 ENOG4105CYC Transferase AQ16_676 ENOG4105DY9 regulatoR AQ16_679 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AQ16_68 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AQ16_680 ENOG4105C6X Major Facilitator AQ16_685 ENOG4105C7B Threonine dehydratase AQ16_689 ENOG4105C7K acetolactate synthase AQ16_69 ENOG4107QX3 carboxylase AQ16_690 ENOG4105CM2 brancheD-chain amino acid aminotransferase AQ16_691 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AQ16_695 ENOG4105H67 Protein of unknown function (DUF421) AQ16_696 ENOG4105X5K response regulator receiver protein AQ16_698 ENOG4105C8J )-transporter AQ16_70 ENOG4105E39 Enoyl-CoA hydratase AQ16_702 ENOG4105C6T cysteine synthase AQ16_703 ENOG4105EU0 Major facilitator Superfamily AQ16_705 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AQ16_709 ENOG4105DXI Major Facilitator superfamily AQ16_71 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AQ16_710 ENOG4105CSR polyphosphate kinase 2 AQ16_717 ENOG4105FVX AQ16_72 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit AQ16_722 ENOG41067QW Transcriptional regulator AQ16_725 ENOG4105C0D helicase AQ16_728 ENOG4105C6K Malic enzyme AQ16_729 ENOG4108IJ0 Aspartate ammonia-lyase AQ16_73 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AQ16_731 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AQ16_737 ENOG4105CJ1 ABC, transporter AQ16_74 ENOG4105C1G acyl-Coa dehydrogenase AQ16_744 ENOG4106BRA Membrane AQ16_750 ENOG4107QIV Cytochrome c biogenesis protein AQ16_754 ENOG4105EC3 peptidase S51, dipeptidase E AQ16_755 ENOG4107QJQ Mate efflux family protein AQ16_759 ENOG4105C9Q fumarate hydratase class II AQ16_761 ENOG4105C9Q fumarate hydratase class II AQ16_762 ENOG4105EMU Dehydrogenase AQ16_763 ENOG4105VUF Transcriptional regulator AQ16_764 ENOG4105DFD Na H antiporter AQ16_767 ENOG4108PJD permease AQ16_768 ENOG4105CKI cobalamin synthesis protein AQ16_769 ENOG4108UZ3 Transporter AQ16_77 ENOG4107Z3H Transcriptional regulator, TetR family AQ16_770 ENOG4105DRR Transcriptional regulator, GntR family AQ16_772 ENOG4105PGM cation diffusion facilitator family transporter AQ16_776 ENOG4105CAQ asparagine synthetase AQ16_778 ENOG4105K56 Transcriptional regulator AQ16_780 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AQ16_783 ENOG4105CVJ phosphoglycerate mutase AQ16_79 ENOG4105CJ1 ABC, transporter AQ16_791 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component AQ16_792 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AQ16_793 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AQ16_794 ENOG4105DUM transcriptional regulator, lysR family AQ16_800 ENOG4108U4N (sortase) family AQ16_806 ENOG4105KAC Antibiotic biosynthesis monooxygenase AQ16_81 ENOG4107RGJ metallophosphoesterase AQ16_814 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AQ16_815 ENOG4105KTQ flagellar basal-body rod protein AQ16_816 ENOG4105FZW flagellar biosynthesis regulator FlhF AQ16_817 ENOG4105D7B Flagellar biosynthesis protein flha AQ16_818 ENOG4105D00 flagellar biosynthetic protein flhB AQ16_820 ENOG4105VS8 Flagellar biosynthetic protein fliq AQ16_821 ENOG4105CN7 Flagellar biosynthetic protein FliP AQ16_823 ENOG4105DD5 Flagellar motor switch protein AQ16_824 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AQ16_826 ENOG4105E4C Lytic transglycosylase catalytic AQ16_827 ENOG4105I03 Flagellin AQ16_828 ENOG4105I03 Flagellin AQ16_829 ENOG4105I03 Flagellin AQ16_83 ENOG4107RF6 penicillin-binding protein AQ16_830 ENOG4105I03 Flagellin AQ16_831 ENOG4105I03 Flagellin AQ16_833 ENOG4107R88 Chemotaxis protein (CheV) AQ16_836 ENOG4105BZE flagellar hook protein, FlgE AQ16_84 ENOG4107RF6 penicillin-binding protein AQ16_842 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AQ16_843 ENOG4107U2N Flagellar M-ring protein AQ16_844 ENOG41075Z6 flagellar hook-basal body complex protein fliE AQ16_845 ENOG4108ZC9 flagellar basal-body rod protein flgc AQ16_846 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AQ16_849 ENOG410804A Flagellar hook-associated 2 domain-containing protein AQ16_851 ENOG4105E1Q flagellar hook-associated protein AQ16_855 ENOG4105BZU Histidine kinase AQ16_858 ENOG4105DD5 Flagellar motor switch protein AQ16_859 ENOG4105CBS Chea signal transduction histidine kinase AQ16_860 ENOG4107YTP response regulator receiver protein AQ16_861 ENOG4106VK6 Flagellar motor protein AQ16_862 ENOG4107R0U MotA TolQ exbB proton channel AQ16_864 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AQ16_87 ENOG4107RVG penicillin-binding protein AQ16_875 ENOG41080C8 DUF218 domain AQ16_876 ENOG4105H67 Protein of unknown function (DUF421) AQ16_878 ENOG4108Z5V transcriptional regulator, merr family AQ16_879 ENOG4105CN5 Metallo-Beta-Lactamase AQ16_88 ENOG4107RVG penicillin-binding protein AQ16_880 ENOG4107RWR Sodium hydrogen exchanger AQ16_882 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AQ16_895 ENOG41081VK Ribonuclease AQ16_899 ENOG4108SZE gCN5-related N-acetyltransferase AQ16_90 ENOG4108ZJ4 polysaccharide deacetylase AQ16_902 ENOG4105CPK Glycosyl transferase (Group 1 AQ16_91 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) AQ16_914 ENOG4106032 Glutathionylspermidine synthase AQ16_917 ENOG4105KHC sulfurtransferase AQ16_919 ENOG4108W0I acetyltransferase AQ16_92 ENOG4105CVK Glutamate decarboxylase AQ16_921 ENOG410890F Dynamin family AQ16_923 ENOG4105DHF Membrane AQ16_924 ENOG4105C2W permease AQ16_925 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) AQ16_926 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AQ16_928 ENOG4105CTD carboxy-peptidase AQ16_929 ENOG4105DVT helicase AQ16_93 ENOG4105F6S Spore photoproduct lyase AQ16_931 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AQ16_942 ENOG4105BZ4 penicillin-binding protein AQ16_944 ENOG4105CSM endonuclease III AQ16_948 ENOG4105YAC AQ16_949 ENOG4105DVT helicase AQ16_956 ENOG4105CPK Glycosyl transferase (Group 1 AQ16_957 ENOG4105FJR Lmbe family AQ16_960 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase AQ16_961 ENOG4108JYZ YitT family AQ16_968 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AQ16_969 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) AQ16_97 ENOG4105C44 Serine transporter AQ16_972 ENOG41068YB TPR repeat-containing protein AQ16_977 ENOG4105EAH synthase AQ16_979 ENOG4105XXQ heptaprenyl diphosphate synthase component I AQ16_98 ENOG4105EJQ L-serine dehydratase AQ16_982 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) AQ16_988 ENOG41065D1 AQ16_989 ENOG4105S2F AQ16_996 ENOG4107RB3 L-asparaginase AQ16_997 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase