locus-tag class description BCG9842_0007 ENOG4105BZU Histidine kinase BCG9842_0008 ENOG4105WH1 Two component transcriptional regulator luxr family BCG9842_0015 ENOG4105C6E dna polymerase iii BCG9842_0023 ENOG4105C3F Signal peptidase i BCG9842_0043 ENOG4105TQK DNA polymerase iii, delta' subunit BCG9842_0057 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BCG9842_0058 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BCG9842_0059 ENOG4105KRN Transcriptional regulator, abrb family BCG9842_0086 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BCG9842_0092 ENOG4105ENA helicase BCG9842_0093 ENOG4105FA2 dna polymerase iii BCG9842_0103 ENOG4107Y9E nuclease BCG9842_0106 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BCG9842_0125 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BCG9842_0132 ENOG4105C79 DNA protecting protein DprA BCG9842_0140 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BCG9842_0169 ENOG4108IYH Dna topoisomerase BCG9842_0170 ENOG4106F1P AAA ATPase, central domain protein BCG9842_0175 ENOG4107SN7 NLP P60 protein BCG9842_0186 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BCG9842_0216 ENOG4105CDU Replicative dna helicase BCG9842_A0019 ENOG41086IN PA14 BCG9842_A0033 ENOG4105CDU Replicative dna helicase BCG9842_A0045 ENOG4105C0B DNA polymerase III (alpha subunit) BCG9842_A0047 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BCG9842_A0072 ENOG4105C0D helicase BCG9842_A0107 ENOG4105K4H Nlp p60 protein BCG9842_B0009 ENOG4105CM4 permease protein BCG9842_B0010 ENOG4108IPW abc transporter atp-binding protein BCG9842_B0013 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) BCG9842_B0014 ENOG4108V2W Carbonate dehydratase BCG9842_B0018 ENOG4108W2Y isochorismatase BCG9842_B0020 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BCG9842_B0022 ENOG4108MK9 spermidine N(1)-acetyltransferase BCG9842_B0023 ENOG4105C5H ABC transporter BCG9842_B0027 ENOG4105WMR Protein CrcB homolog BCG9842_B0030 ENOG4105C8Q Methyl-accepting chemotaxis BCG9842_B0032 ENOG4105D4A Cell wall formation (By similarity) BCG9842_B0033 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BCG9842_B0036 ENOG4105KVH Transcriptional regulator BCG9842_B0037 ENOG4105F27 Major Facilitator BCG9842_B0038 ENOG4105CV8 reductase BCG9842_B0041 ENOG4108RYK Nad-dependent epimerase dehydratase BCG9842_B0044 ENOG4105D9N nucleoside BCG9842_B0045 ENOG4105DHF Membrane BCG9842_B0046 ENOG41090A1 ferritin BCG9842_B0048 ENOG4108URH decarboxylase BCG9842_B0052 ENOG4108RMU ferritin dps family protein BCG9842_B0055 ENOG4105NCW Trka-c domain protein BCG9842_B0056 ENOG4107S91 Sodium hydrogen exchanger BCG9842_B0057 ENOG4107T5V SNARE associated Golgi BCG9842_B0060 ENOG4105C2I pirin domain protein BCG9842_B0061 ENOG4105D4Y metalloprotease BCG9842_B0062 ENOG4105VG1 fes assembly suf system protein BCG9842_B0063 ENOG4105C8Q Methyl-accepting chemotaxis BCG9842_B0065 ENOG4105C8Q Methyl-accepting chemotaxis BCG9842_B0070 ENOG4105BZU Histidine kinase BCG9842_B0071 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BCG9842_B0072 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BCG9842_B0074 ENOG4107ZTW SNARE associated Golgi BCG9842_B0080 ENOG4107AYK membrAne BCG9842_B0082 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BCG9842_B0084 ENOG4107R7I amino acid BCG9842_B0085 ENOG4108SUT Major Facilitator Superfamily BCG9842_B0088 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BCG9842_B0092 ENOG4105DZ1 carboxypeptidase BCG9842_B0095 ENOG4105CHU acetyl-coa acetyltransferase BCG9842_B0096 ENOG4105C1G acyl-Coa dehydrogenase BCG9842_B0097 ENOG4108W8B Beta-lactamase domain protein BCG9842_B0100 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BCG9842_B0104 ENOG41080E8 Transcriptional regulator, Spx MgsR family BCG9842_B0111 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BCG9842_B0112 ENOG4108UMI ABC transporter, permease BCG9842_B0113 ENOG4105D01 (LipO)protein BCG9842_B0114 ENOG4105D01 (LipO)protein BCG9842_B0115 ENOG4105C3K feS assembly ATPase SufC BCG9842_B0116 ENOG4105JRK feS assembly protein SufD BCG9842_B0117 ENOG4105C9B Cysteine desulfurase BCG9842_B0118 ENOG4108UNV SUF system FeS assembly protein, NifU family BCG9842_B0119 ENOG4105DIW FeS assembly protein SUFB BCG9842_B0120 ENOG4107R8B 5'-nucleotidase BCG9842_B0121 ENOG4105KZD Domain of unknown function (DUF1805) BCG9842_B0122 ENOG4108YTE sporulation protein YunB BCG9842_B0123 ENOG4105FAA peptidase M23 BCG9842_B0128 ENOG41090T1 Membrane BCG9842_B0129 ENOG4107TXC Transcriptional regulator BCG9842_B0130 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BCG9842_B0131 ENOG4105MMD transcriptional regulator BCG9842_B0134 ENOG4105CBT Fructose-1,6-bisphosphatase BCG9842_B0137 ENOG4105D4U had-superfamily hydrolase, subfamily iia BCG9842_B0139 ENOG4105DYS nad(p)h dehydrogenase (quinone) BCG9842_B0141 ENOG4105DAX Pfam:DUF2983 BCG9842_B0145 ENOG4108W5N phosphatidylglycerophosphatase a BCG9842_B0148 ENOG41083MR nifu domain-containing protein BCG9842_B0160 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BCG9842_B0161 ENOG4105C4B ABC transporter, permease BCG9842_B0162 ENOG4108JJA ABC, transporter BCG9842_B0167 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BCG9842_B0172 ENOG4105EWC Purine nucleoside phosphorylase BCG9842_B0177 ENOG4105CEP NADH dehydrogenase BCG9842_B0180 ENOG41069ER domain protein BCG9842_B0184 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BCG9842_B0187 ENOG4105KA0 thioesterase Superfamily protein BCG9842_B0188 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BCG9842_B0191 ENOG4107R3E Citrate transporter BCG9842_B0193 ENOG4105Y38 Kinase-associated protein B BCG9842_B0196 ENOG4105C87 Aminotransferase class I and II BCG9842_B0198 ENOG4108MUZ hydrolase BCG9842_B0199 ENOG4105C5I Dehydrogenase BCG9842_B0200 ENOG4108ZB6 transcriptional regulator AsnC family BCG9842_B0201 ENOG4105CHM Aminotransferase BCG9842_B0203 ENOG4105WG9 Conserved Protein BCG9842_B0205 ENOG4107PBV potassium channel BCG9842_B0207 ENOG4105KT7 mgtC SapB transporter BCG9842_B0235 ENOG4108Q5F Tetr family transcriptional regulator BCG9842_B0236 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BCG9842_B0239 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BCG9842_B0248 ENOG4105VEQ Cold shock protein BCG9842_B0250 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BCG9842_B0251 ENOG4105E4F Isochorismate synthase BCG9842_B0253 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BCG9842_B0254 ENOG4108IPT Naphthoate synthase BCG9842_B0256 ENOG4105DTQ mandelate racemase muconate lactonizing BCG9842_B0260 ENOG41069H0 dihydroorotase EC 3.5.2.3 BCG9842_B0264 ENOG4105FDP GntR family transcriptional regulator BCG9842_B0265 ENOG4105C6Z Gluconate BCG9842_B0274 ENOG41082BM Transcriptional regulator, arsr family BCG9842_B0276 ENOG4105CJ1 ABC, transporter BCG9842_B0278 ENOG41086D8 Transcriptional regulator BCG9842_B0279 ENOG4105C19 ABC transporter BCG9842_B0282 ENOG4107ZTW SNARE associated Golgi BCG9842_B0284 ENOG4105BZU Histidine kinase BCG9842_B0296 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BCG9842_B0297 ENOG4108UGV hypoxanthine phosphoribosyltransferase BCG9842_B0302 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BCG9842_B0303 ENOG4105BZU Histidine kinase BCG9842_B0304 ENOG4105N67 Proton-coupled thiamine transporter YuaJ BCG9842_B0310 ENOG41087YS Phage shock protein A BCG9842_B0318 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BCG9842_B0319 ENOG4105C4M (Ubiquinol oxidase) subunit I BCG9842_B0321 ENOG4108V2W Carbonate dehydratase BCG9842_B0324 ENOG410839T multidrug resistance protein BCG9842_B0325 ENOG41080TC multidrug resistance protein BCG9842_B0335 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BCG9842_B0337 ENOG4105D2X ABC transporter substrate-binding protein BCG9842_B0342 ENOG4107T7U Sulfatase BCG9842_B0343 ENOG4107S9D Alpha beta hydrolase BCG9842_B0344 ENOG4105CH6 catalase BCG9842_B0346 ENOG4105BZU Histidine kinase BCG9842_B0347 ENOG4105BZU Histidine kinase BCG9842_B0366 ENOG4105EPU Molybdenum cofactor synthesis domain protein BCG9842_B0368 ENOG4105BZF Glycosyl transferase (Group 1 BCG9842_B0369 ENOG4105YVM Phosphoesterase, PA-phosphatase related BCG9842_B0370 ENOG4108Z0R Transferase BCG9842_B0371 ENOG4105E8V Alpha Beta Hydrolase Fold protein BCG9842_B0376 ENOG4105N5T Radical SAM Protein BCG9842_B0380 ENOG4105C19 ABC transporter BCG9842_B0383 ENOG4105NCW Trka-c domain protein BCG9842_B0384 ENOG4107S91 Sodium hydrogen exchanger BCG9842_B0385 ENOG410605W Major Facilitator BCG9842_B0393 ENOG4105DWV Homoserine O-trans-acetylase BCG9842_B0395 ENOG41085GJ domain protein BCG9842_B0399 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BCG9842_B0400 ENOG4105D06 uba thif-type nad fad binding protein BCG9842_B0402 ENOG4105CVM Molybdenum cofactor synthesis domain protein BCG9842_B0403 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BCG9842_B0404 ENOG4108ZAF Molybdopterin BCG9842_B0407 ENOG4105CSC Glucose uptake protein BCG9842_B0408 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BCG9842_B0409 ENOG4108VJ1 Transcriptional regulator (CarD family BCG9842_B0416 ENOG4105CBX hi0933 family BCG9842_B0419 ENOG4105YW5 deoR family transcriptional regulator BCG9842_B0420 ENOG4107QSE Dipeptidase BCG9842_B0422 ENOG4108IUM Glycogen debranching enzyme BCG9842_B0423 ENOG4108V15 phosphotransferase enzyme family BCG9842_B0426 ENOG4105C8F Beta-lactamase domain protein BCG9842_B0432 ENOG4108VDD TRNA binding domain protein BCG9842_B0439 ENOG4108IPJ Membrane BCG9842_B0443 ENOG4105C88 aminopeptidase BCG9842_B0447 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BCG9842_B0448 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BCG9842_B0449 ENOG4105ETE Transcriptional regulator (LacI family BCG9842_B0455 ENOG4105EP9 oxidoreductase BCG9842_B0456 ENOG4107SNB ankyrin repeat protein YahD BCG9842_B0457 ENOG4105BZU Histidine kinase BCG9842_B0458 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BCG9842_B0461 ENOG4105DGU Histone deacetylase BCG9842_B0462 ENOG4105W87 Cbs domain BCG9842_B0463 ENOG4105F1V Acetoin utilization protein BCG9842_B0465 ENOG4108UW5 maltose o-acetyltransferase BCG9842_B0470 ENOG4108IBT Inherit from COG: transposase BCG9842_B0472 ENOG4105C28 cystathionine BCG9842_B0474 ENOG4105U5Y Transcriptional regulator BCG9842_B0476 ENOG4105RQF LysR family Transcriptional regulator BCG9842_B0481 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BCG9842_B0483 ENOG4105EFZ amidohydrolase BCG9842_B0486 ENOG4105KBJ sporulation protein ytfj BCG9842_B0487 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BCG9842_B0489 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BCG9842_B0493 ENOG4108JYZ YitT family BCG9842_B0502 ENOG4107YZX Universal stress protein BCG9842_B0506 ENOG41082W1 Cupin 2, conserved barrel domain protein BCG9842_B0507 ENOG4105Z7P Acetyltransferase (GNAT) family BCG9842_B0514 ENOG4105DC7 peptidase M24 BCG9842_B0520 ENOG4105SFS phosphoesterase RecJ domain protein BCG9842_B0522 ENOG4105VV2 BCG9842_B0523 ENOG4105C0B DNA polymerase III (alpha subunit) BCG9842_B0524 ENOG4105C6K Malic enzyme BCG9842_B0525 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BCG9842_B0530 ENOG4105FS0 cytoplasmic membrane protein BCG9842_B0531 ENOG4108REF Sporulation integral membrane protein ytvi BCG9842_B0534 ENOG4105BZN citrate synthase BCG9842_B0535 ENOG4108HMX isocitrate dehydrogenase (NADP) BCG9842_B0539 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BCG9842_B0540 ENOG4105BZU Histidine kinase BCG9842_B0541 ENOG4105C2M dna polymerase I BCG9842_B0542 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BCG9842_B0544 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BCG9842_B0545 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BCG9842_B0547 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BCG9842_B0551 ENOG4108TDW sporulation protein YtxC BCG9842_B0552 ENOG4105C22 threonyL-tRNA synthetase BCG9842_B0554 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BCG9842_B0558 ENOG4105CN9 Peptidase m42 family protein BCG9842_B0559 ENOG4108JGH Tetr family transcriptional regulator BCG9842_B0560 ENOG4105CW7 secretion protein, HlyD family BCG9842_B0561 ENOG4105C0R drug resistance transporter emrb qaca subfamily BCG9842_B0566 ENOG4108RWN rrna methyltransferase BCG9842_B0568 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BCG9842_B0569 ENOG4105C5S asparaginyl-tRNA synthetase BCG9842_B0572 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BCG9842_B0575 ENOG4105DCG PHP domain protein BCG9842_B0577 ENOG4105FE9 pseudouridine synthase BCG9842_B0579 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BCG9842_B0581 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BCG9842_B0584 ENOG4105E0A ABC, transporter BCG9842_B0585 ENOG4105KFN sortase, SrtB family BCG9842_B0587 ENOG4105DR4 Methyltransferase BCG9842_B0590 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BCG9842_B0598 ENOG4105S6R Iron-hydroxamate transporter permease subunit BCG9842_B0599 ENOG4105J76 Periplasmic binding protein BCG9842_B0601 ENOG4105CEY Amp-dependent synthetase and ligase BCG9842_B0602 ENOG4107Z3H Transcriptional regulator, TetR family BCG9842_B0603 ENOG41060WC Enoyl-CoA hydratase BCG9842_B0604 ENOG4105BZJ Electron transfer flavoprotein BCG9842_B0605 ENOG4105C10 Electron transfer flavoprotein BCG9842_B0606 ENOG4105K63 Thioredoxin BCG9842_B0609 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BCG9842_B0611 ENOG4105E33 succinate dehydrogenase BCG9842_B0613 ENOG4108VXD carboxy-peptidase BCG9842_B0614 ENOG4105E14 MotA TolQ exbB proton channel BCG9842_B0615 ENOG4105ER2 Ompa motb domain protein BCG9842_B0616 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BCG9842_B0617 ENOG4108IUX (ABC) transporter BCG9842_B0618 ENOG4105RHA ABC transporter, permease BCG9842_B0619 ENOG4108Z40 Transcriptional regulator BCG9842_B0620 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BCG9842_B0622 ENOG4108JCI Transcriptional regulator BCG9842_B0623 ENOG41067S9 phage shock protein C, PspC BCG9842_B0624 ENOG4105DZC cytosine deaminase BCG9842_B0626 ENOG4105PFC Transcriptional regulator BCG9842_B0628 ENOG4105KBX Transcriptional regulator, TetR family BCG9842_B0630 ENOG4108PCX Major Facilitator BCG9842_B0633 ENOG4108XJQ germination protein BCG9842_B0636 ENOG4105M59 Phosphodiesterase, mj0936 family BCG9842_B0640 ENOG4108QCI YvbH-like oligomerisation region BCG9842_B0645 ENOG4108IUQ atp-dependent protease BCG9842_B0649 ENOG4105K56 Transcriptional regulator BCG9842_B0654 ENOG4105D52 delta-aminolevulinic acid dehydratase BCG9842_B0656 ENOG41068KH stage VI sporulation protein D BCG9842_B0658 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BCG9842_B0659 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BCG9842_B0663 ENOG4105DFF Rod shape-determining protein mreb BCG9842_B0664 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BCG9842_B0667 ENOG4107QMS site-determining protein BCG9842_B0670 ENOG4105C03 ribonuclease BCG9842_B0673 ENOG4105X36 (ribosomal) protein BCG9842_B0678 ENOG4105EWM Histidine kinase BCG9842_B0682 ENOG4105CQC Prephenate dehydratase BCG9842_B0684 ENOG4108RPX mosc domain containing protein BCG9842_B0687 ENOG4108IYU L-aspartate oxidase BCG9842_B0688 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BCG9842_B0694 ENOG4108HUF Transporter BCG9842_B0697 ENOG41061AI Protein of unknown function (DUF2905) BCG9842_B0700 ENOG4105VIE preprotein translocase, subunit YajC BCG9842_B0702 ENOG4108QG2 Membrane BCG9842_B0703 ENOG4105CKP Polysaccharide Biosynthesis Protein BCG9842_B0705 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BCG9842_B0706 ENOG41076HS cation diffusion facilitator family transporter BCG9842_B0707 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BCG9842_B0709 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BCG9842_B0713 ENOG4105CUT histidyl-tRNA synthetase BCG9842_B0715 ENOG4105CUZ uba thif-type nad fad binding protein BCG9842_B0716 ENOG4108VCI transcription factor, rsfa family BCG9842_B0717 ENOG4105D1H recombination factor protein RarA BCG9842_B0719 ENOG4105C3J Cysteine desulfurase BCG9842_B0720 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BCG9842_B0722 ENOG4105C7H Helicase, RecD TraA family BCG9842_B0723 ENOG41060CR BCG9842_B0726 ENOG4105C02 permease BCG9842_B0728 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BCG9842_B0732 ENOG4105HHA aminodeoxychorismate lyase BCG9842_B0733 ENOG4108VQJ O-methyltransferase BCG9842_B0734 ENOG4105XYU peptidase (U32 family) BCG9842_B0735 ENOG4105CFP Peptidase U32 BCG9842_B0737 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BCG9842_B0739 ENOG4107XRG penicillin-binding protein BCG9842_B0745 ENOG4105C28 cystathionine BCG9842_B0746 ENOG4108EKI Dehydrogenase BCG9842_B0748 ENOG4108HUF Transporter BCG9842_B0749 ENOG4105S6R Iron-hydroxamate transporter permease subunit BCG9842_B0757 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BCG9842_B0759 ENOG4105MIR Phenylalanine 4-monooxygenase BCG9842_B0761 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BCG9842_B0769 ENOG4108MUZ hydrolase BCG9842_B0770 ENOG4105KEG ribosomal-protein-alanine acetyltransferase BCG9842_B0771 ENOG4105G6Z alkaline phosphatase BCG9842_B0774 ENOG4108TVJ Nitroreductase BCG9842_B0778 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BCG9842_B0781 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BCG9842_B0782 ENOG4105CQW ribosome biogenesis GTPase YqeH BCG9842_B0784 ENOG410812S Rna-binding protein BCG9842_B0786 ENOG4108WF2 Metal Dependent Phosphohydrolase BCG9842_B0788 ENOG4105DXX methyltransferase BCG9842_B0790 ENOG4105KQC Competence protein BCG9842_B0791 ENOG4108UK2 deaminase BCG9842_B0792 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BCG9842_B0794 ENOG4105TQK DNA polymerase iii, delta' subunit BCG9842_B0799 ENOG4105KVH Transcriptional regulator BCG9842_B0800 ENOG4105CSA Coproporphyrinogen iii oxidase BCG9842_B0806 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BCG9842_B0807 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BCG9842_B0809 ENOG4105KTH gatB Yqey BCG9842_B0812 ENOG41068P3 sporulation protein YqfC BCG9842_B0814 ENOG4105C9A Phoh family BCG9842_B0815 ENOG4105CTJ Metal Dependent Phosphohydrolase BCG9842_B0817 ENOG4107YR5 Diacylglycerol kinase BCG9842_B0818 ENOG4105KG3 cytidine deaminase BCG9842_B0819 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BCG9842_B0824 ENOG4107XJU UPF0178 protein BCG9842_B0825 ENOG4107XJU UPF0178 protein BCG9842_B0826 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BCG9842_B0827 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BCG9842_B0830 ENOG4105EGD dinuclear metal center protein, YbgI family BCG9842_B0835 ENOG41069ZM Protein of unknown function (DUF2624) BCG9842_B0836 ENOG4108JYZ YitT family BCG9842_B0837 ENOG4105FDK ABC transporter BCG9842_B0839 ENOG4105N80 Ferric uptake regulator, Fur family BCG9842_B0845 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BCG9842_B0847 ENOG4107RF6 penicillin-binding protein BCG9842_B0849 ENOG4105C8U phosphate abc transporter BCG9842_B0850 ENOG4105C8U phosphate abc transporter BCG9842_B0851 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BCG9842_B0852 ENOG4108UTW Plays a role in the regulation of phosphate uptake BCG9842_B0855 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BCG9842_B0857 ENOG4105DKQ ROK family BCG9842_B0859 ENOG4105C5X domain protein BCG9842_B0863 ENOG4105C28 cystathionine BCG9842_B0864 ENOG4105C28 cystathionine BCG9842_B0868 ENOG4105C3R Methionine synthase BCG9842_B0869 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BCG9842_B0876 ENOG4107R6U sodium dicarboxylate symporter BCG9842_B0900 ENOG4105C0D helicase BCG9842_B0908 ENOG41080TC multidrug resistance protein BCG9842_B0913 ENOG4105WZW rhodanese family BCG9842_B0914 ENOG41082GG biotin lipoate A B protein ligase BCG9842_B0922 ENOG4107YBY Hydrolase BCG9842_B0923 ENOG4105CBJ Metal-dependent enzyme BCG9842_B0926 ENOG4105DC7 peptidase M24 BCG9842_B0931 ENOG4105CD2 stage iii sporulation protein aa BCG9842_B0932 ENOG4105KR5 Stage iii sporulation protein BCG9842_B0933 ENOG4108CQH stage III sporulation protein AC BCG9842_B0934 ENOG4105KQ4 Stage iii sporulation protein ad BCG9842_B0936 ENOG410644B Stage III sporulation protein af BCG9842_B0940 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BCG9842_B0941 ENOG4108ZSR alkaline shock protein BCG9842_B0946 ENOG4105CTB Polyprenyl synthetase BCG9842_B0948 ENOG4105DX0 Hemolysin A BCG9842_B0949 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BCG9842_B0950 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BCG9842_B0951 ENOG4105S1Z Stage IV sporulation protein B BCG9842_B0952 ENOG4107QQR Sporulation BCG9842_B0955 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BCG9842_B0957 ENOG4108JUB Transcriptional regulator BCG9842_B0959 ENOG4107RDP Dehydrogenase BCG9842_B0963 ENOG4105CPP Dehydrogenase, E1 component BCG9842_B0964 ENOG4105C7S Dehydrogenase BCG9842_B0966 ENOG4108QY0 Membrane BCG9842_B0968 ENOG4105G7B Protein of unknown function (DUF2992) BCG9842_B0971 ENOG4108HW3 (ABC) transporter BCG9842_B0972 ENOG4105E5Q amino acid AbC transporter BCG9842_B0973 ENOG4105CDA abc transporter atp-binding protein BCG9842_B0974 ENOG4108QEG Membrane BCG9842_B0975 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BCG9842_B0977 ENOG4105D9U N-acetyltransferase BCG9842_B0978 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BCG9842_B0981 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic BCG9842_B0989 ENOG4105EJQ L-serine dehydratase BCG9842_B0990 ENOG4105II7 pyrroline-5-carboxylate reductase BCG9842_B0991 ENOG41069FQ Metallo-beta-lactamase superfamily BCG9842_B0992 ENOG4108IXY short-chain dehydrogenase reductase BCG9842_B0995 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BCG9842_B0998 ENOG4105DBV ornithine carbamoyltransferase BCG9842_B1003 ENOG4105CGH 5'-nucleotidase BCG9842_B1004 ENOG4105DFD Na H antiporter BCG9842_B1007 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BCG9842_B1010 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BCG9842_B1011 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BCG9842_B1016 ENOG4108R6K riboflavin synthase, subunit alpha BCG9842_B1017 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BCG9842_B1022 ENOG4108YM7 Gcn5-related n-acetyltransferase BCG9842_B1023 ENOG4105ETE Transcriptional regulator (LacI family BCG9842_B1025 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BCG9842_B1029 ENOG4105RHY Pfam:UPF0157 BCG9842_B1031 ENOG4105CPC Aldo Keto reductase BCG9842_B1035 ENOG4105MZ9 stage II sporulation protein m BCG9842_B1036 ENOG4105I3K Ferric uptake regulator, Fur family BCG9842_B1038 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BCG9842_B1043 ENOG4105D7N magnesium and cobalt transport protein CorA BCG9842_B1051 ENOG4105DVE abc transporter atp-binding protein BCG9842_B1052 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BCG9842_B1053 ENOG4105DZ1 carboxypeptidase BCG9842_B1054 ENOG41082AN stage II sporulation protein BCG9842_B1056 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BCG9842_B1057 ENOG4105C8J )-transporter BCG9842_B1061 ENOG41090VF Stage v sporulation protein ac BCG9842_B1062 ENOG4105CZ3 stage V sporulation protein ad BCG9842_B1064 ENOG4105G6R Stage v sporulation protein ae BCG9842_B1066 ENOG4105J7I hydrolase BCG9842_B1067 ENOG4105PTM secreted protein BCG9842_B1068 ENOG4107ZE5 PPIases accelerate the folding of proteins BCG9842_B1074 ENOG4105CE4 GlcNAc 6-P deacetylase BCG9842_B1076 ENOG4105FDP GntR family transcriptional regulator BCG9842_B1078 ENOG4105CID antiterminator BCG9842_B1081 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BCG9842_B1085 ENOG4105BZU Histidine kinase BCG9842_B1087 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BCG9842_B1090 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BCG9842_B1096 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BCG9842_B1101 ENOG4105DTD Dehydrogenase BCG9842_B1102 ENOG4105K7K Transcriptional regulator BCG9842_B1109 ENOG4105CHU acetyl-coa acetyltransferase BCG9842_B1118 ENOG4105CG3 alpha amylase, catalytic region BCG9842_B1120 ENOG4107FKK extracellular solute-binding protein family 1 BCG9842_B1122 ENOG4105EG2 ABC transporter, permease BCG9842_B1123 ENOG4105FKQ transcriptional regulator BCG9842_B1124 ENOG4105CHM Aminotransferase BCG9842_B1127 ENOG4108HGU Histidine kinase BCG9842_B1139 ENOG4105UIN BCG9842_B1141 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BCG9842_B1142 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BCG9842_B1145 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BCG9842_B1146 ENOG4105EPM Diguanylate phosphodiesterase BCG9842_B1150 ENOG4107IN1 Protein of unknown function (DUF1797) BCG9842_B1152 ENOG4108XRC Protein of unknown function (DUF458) BCG9842_B1159 ENOG4107ZYR domain protein BCG9842_B1160 ENOG4105CN5 Metallo-Beta-Lactamase BCG9842_B1162 ENOG4108X4Q Hydrolase BCG9842_B1163 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BCG9842_B1166 ENOG4105CPP Dehydrogenase, E1 component BCG9842_B1175 ENOG4105CXN decarboxylase BCG9842_B1179 ENOG4105ECY inositol monophosphatase BCG9842_B1181 ENOG4105CI3 gtp-binding protein typa BCG9842_B1182 ENOG4105QA2 BCG9842_B1186 ENOG4108IAB Phoh family BCG9842_B1189 ENOG4105CNI cell division protein FtsW BCG9842_B1190 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BCG9842_B1200 ENOG4106UY4 Inherit from COG: Scp-like extracellular BCG9842_B1203 ENOG4107TB6 phosphoglycerate mutase BCG9842_B1208 ENOG4106H78 methyltransferase BCG9842_B1209 ENOG4105H20 Sporulation integral membrane protein YlbJ BCG9842_B1211 ENOG4105D78 K07001 NTE family protein BCG9842_B1212 ENOG41063PX domain protein BCG9842_B1214 ENOG4105DQ6 Transposase BCG9842_B1216 ENOG4105KNH Nucleic acid-binding protein BCG9842_B1224 ENOG4105CJN penicillin-binding protein BCG9842_B1225 ENOG4105CJN penicillin-binding protein BCG9842_B1226 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BCG9842_B1229 ENOG4105CNI cell division protein FtsW BCG9842_B1230 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BCG9842_B1231 ENOG4105D4A Cell wall formation (By similarity) BCG9842_B1233 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BCG9842_B1234 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BCG9842_B1236 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BCG9842_B1238 ENOG4105WR5 sporulation protein, YlmC YmxH family BCG9842_B1239 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BCG9842_B1240 ENOG4105DFA alanine racemase domain protein BCG9842_B1242 ENOG41067XK integral membrane protein BCG9842_B1243 ENOG4105DBK s4 domain protein BCG9842_B1248 ENOG4105C34 Pseudouridine synthase BCG9842_B1268 ENOG4105DC7 peptidase M24 BCG9842_B1269 ENOG4105F23 Fibronectin-binding protein BCG9842_B1271 ENOG4105DSJ YicC domain protein BCG9842_B1275 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BCG9842_B1276 ENOG4105C25 Primosomal protein n' BCG9842_B1279 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BCG9842_B1281 ENOG4108ZF3 Phosphatase BCG9842_B1282 ENOG4105D9P serine threonine protein kinase BCG9842_B1283 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BCG9842_B1284 ENOG4105DJV ribulose-phosphate 3-epimerase BCG9842_B1285 ENOG4105FJ0 thiamine BCG9842_B1287 ENOG4108ZAA Alkaline-shock protein BCG9842_B1288 ENOG4105DP4 dak2 domain fusion protein ylov BCG9842_B1289 ENOG4105CB5 ATP-dependent DNA helicase recG BCG9842_B1292 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BCG9842_B1293 ENOG4105CHR reductase BCG9842_B1296 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BCG9842_B1297 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BCG9842_B1301 ENOG4105VB6 UPF0109 protein BCG9842_B1307 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BCG9842_B1310 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BCG9842_B1311 ENOG4105C79 DNA protecting protein DprA BCG9842_B1312 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BCG9842_B1314 ENOG4108HE4 integrase family BCG9842_B1320 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BCG9842_B1323 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BCG9842_B1324 ENOG4105KNE Phosphatidate cytidylyltransferase BCG9842_B1325 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BCG9842_B1326 ENOG4105DZP Membrane-associated zinc metalloprotease BCG9842_B1328 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BCG9842_B1330 ENOG4105CHV Transcription elongation factor NusA BCG9842_B1331 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BCG9842_B1332 ENOG4105VHM ribosomal protein BCG9842_B1334 ENOG4105W7A Protein of unknown function (DUF503) BCG9842_B1337 ENOG4105DTN riboflavin biosynthesis protein ribF BCG9842_B1341 ENOG4105C1V Peptidase, M16 BCG9842_B1343 ENOG4105E35 Dipicolinate synthase subunit A BCG9842_B1344 ENOG4108S0H Dipicolinic acid synthetase, b subunit BCG9842_B1358 ENOG4105CDU Replicative dna helicase BCG9842_B1399 ENOG4108S0H Dipicolinic acid synthetase, b subunit BCG9842_B1400 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BCG9842_B1402 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BCG9842_B1404 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BCG9842_B1406 ENOG4105CNU cell division protein FtsK BCG9842_B1408 ENOG4105FDP GntR family transcriptional regulator BCG9842_B1409 ENOG4105DIH basic membrane BCG9842_B1410 ENOG4108JQ9 ABC transporter BCG9842_B1411 ENOG4105UIB (ABC) transporter BCG9842_B1415 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BCG9842_B1416 ENOG4105XZV Protein of unknown function (DUF3243) BCG9842_B1419 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BCG9842_B1423 ENOG4105D48 metallophosphoesterase BCG9842_B1424 ENOG4105MCT stage V sporulation protein S BCG9842_B1425 ENOG4108IGT Dipeptidase BCG9842_B1426 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BCG9842_B1427 ENOG4105DQU oxidoreductase, subunit beta BCG9842_B1433 ENOG410890F Dynamin family BCG9842_B1434 ENOG4105E0M Sulfatase BCG9842_B1436 ENOG4105F0V Cell wall hydrolase BCG9842_B1438 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C BCG9842_B1439 ENOG4105C8Q Methyl-accepting chemotaxis BCG9842_B1444 ENOG41067MG lrgb family BCG9842_B1451 ENOG4105BZU Histidine kinase BCG9842_B1457 ENOG4105D03 DNA-3-methyladenine glycosylase II BCG9842_B1458 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BCG9842_B1460 ENOG4105CGK Exodeoxyribonuclease III BCG9842_B1465 ENOG4105E0A ABC, transporter BCG9842_B1466 ENOG4105NIV Esterase BCG9842_B1470 ENOG4105VPX protein, conserved in bacteria BCG9842_B1471 ENOG410681U heavy metal transport detoxification protein BCG9842_B1472 ENOG4105C59 p-type ATPase BCG9842_B1474 ENOG4105K70 DNA-binding protein BCG9842_B1475 ENOG4105TMB Formate nitrite transporter BCG9842_B1479 ENOG4105C85 amino acid BCG9842_B1482 ENOG4108SJC Membrane BCG9842_B1483 ENOG4107QW4 alcohol dehydrogenase BCG9842_B1484 ENOG4105E98 transcriptional regulator DeoR family BCG9842_B1485 ENOG4105DE4 1-phosphofructokinase BCG9842_B1486 ENOG4105DM4 PTS System BCG9842_B1487 ENOG41069ER domain protein BCG9842_B1496 ENOG4106F1P AAA ATPase, central domain protein BCG9842_B1498 ENOG4105EN6 Membrane BCG9842_B1499 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BCG9842_B1500 ENOG4105CXI aluminum resistance protein BCG9842_B1501 ENOG4105KV4 Transcriptional regulator BCG9842_B1502 ENOG4105C5F glutamine synthetase BCG9842_B1510 ENOG41065S2 pneumococcal vaccine antigen BCG9842_B1511 ENOG4105E4C Lytic transglycosylase catalytic BCG9842_B1513 ENOG4105K7K Transcriptional regulator BCG9842_B1517 ENOG4108SVB resolvase BCG9842_B1519 ENOG4105CGH 5'-nucleotidase BCG9842_B1520 ENOG4108HW3 (ABC) transporter BCG9842_B1527 ENOG4105BZ1 (ABC) transporter BCG9842_B1528 ENOG4105BZ1 (ABC) transporter BCG9842_B1536 ENOG41067MG lrgb family BCG9842_B1537 ENOG4105VAW lrga family BCG9842_B1538 ENOG4107RSM transcriptional regulator BCG9842_B1542 ENOG4105CJ1 ABC, transporter BCG9842_B1544 ENOG4105CH2 amidohydrolase BCG9842_B1548 ENOG4107QIV Cytochrome c biogenesis protein BCG9842_B1559 ENOG4108903 Formimidoylglutamase BCG9842_B1560 ENOG4108VJ1 Transcriptional regulator (CarD family BCG9842_B1561 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BCG9842_B1562 ENOG4105CBC glutamate synthase BCG9842_B1564 ENOG4105CK7 Sodium proline symporter BCG9842_B1565 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BCG9842_B1566 ENOG4105FBA Phospholipase Carboxylesterase BCG9842_B1567 ENOG4105BZU Histidine kinase BCG9842_B1570 ENOG4107AYK membrAne BCG9842_B1578 ENOG4108IMY Transcriptional regulator BCG9842_B1579 ENOG4105CEY Amp-dependent synthetase and ligase BCG9842_B1580 ENOG4107ZYJ bioY protein BCG9842_B1581 ENOG4107F3J Amp-dependent synthetase and ligase BCG9842_B1585 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BCG9842_B1587 ENOG4105E5W Transporter BCG9842_B1593 ENOG4108I0Z Aconitate hydratase BCG9842_B1594 ENOG4108JJA ABC, transporter BCG9842_B1596 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BCG9842_B1597 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BCG9842_B1602 ENOG4105W8X HesB YadR YfhF-family protein BCG9842_B1603 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BCG9842_B1604 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BCG9842_B1606 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BCG9842_B1607 ENOG4105C0H protease BCG9842_B1608 ENOG4105K4P CoA-binding domain protein BCG9842_B1609 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BCG9842_B1611 ENOG4105D9R oxidoreductase BCG9842_B1615 ENOG4105CIG ABC transporter BCG9842_B1617 ENOG4105EMN RNA polymerase sigma factor BCG9842_B1619 ENOG4108KGH TRANSCRIPTIONal BCG9842_B1620 ENOG4107QJT sodium dicarboxylate symporter BCG9842_B1634 ENOG4105E1K spore germination protein BCG9842_B1636 ENOG4108JB9 formate dehydrogenase BCG9842_B1638 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BCG9842_B1639 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BCG9842_B1641 ENOG4105TMB Formate nitrite transporter BCG9842_B1642 ENOG4105D06 uba thif-type nad fad binding protein BCG9842_B1643 ENOG4105CVM Molybdenum cofactor synthesis domain protein BCG9842_B1644 ENOG4108ZAF Molybdopterin BCG9842_B1646 ENOG4105D1F ATP-binding protein BCG9842_B1649 ENOG410696E Membrane BCG9842_B1650 ENOG4105FR1 rard protein BCG9842_B1652 ENOG4105EWU Squalene--hopene cyclase BCG9842_B1654 ENOG4105CHR reductase BCG9842_B1655 ENOG4105C26 Dehydrogenase BCG9842_B1657 ENOG4108IA2 Sodium pantothenate symporter BCG9842_B1660 ENOG4106IQC argininosuccinate lyase BCG9842_B1662 ENOG410904N short-chain dehydrogenase reductase BCG9842_B1666 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BCG9842_B1670 ENOG4105VEQ Cold shock protein BCG9842_B1673 ENOG4108R1P BCG9842_B1676 ENOG41073R8 VanW family BCG9842_B1677 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BCG9842_B1679 ENOG4105KT7 mgtC SapB transporter BCG9842_B1681 ENOG4105BZU Histidine kinase BCG9842_B1685 ENOG4107DUR UPF0457 protein BCG9842_B1686 ENOG4108VXD carboxy-peptidase BCG9842_B1688 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity BCG9842_B1689 ENOG41067SE Tetr family transcriptional regulator BCG9842_B1690 ENOG4105C5H ABC transporter BCG9842_B1691 ENOG4105BZU Histidine kinase BCG9842_B1702 ENOG4105FAW cDP-glucose 4,6-dehydratase BCG9842_B1705 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase BCG9842_B1709 ENOG4105E1K spore germination protein BCG9842_B1712 ENOG4108M1A Chitin-binding protein BCG9842_B1713 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C BCG9842_B1718 ENOG4105C5E polysaccharide biosynthesis protein BCG9842_B1719 ENOG4105C1B dTDP-glucose 4-6-dehydratase BCG9842_B1720 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BCG9842_B1721 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) BCG9842_B1724 ENOG4105D2T synthase BCG9842_B1727 ENOG4105CNI cell division protein FtsW BCG9842_B1731 ENOG4105CEP NADH dehydrogenase BCG9842_B1735 ENOG4105CQB FAD linked oxidase domain protein BCG9842_B1736 ENOG4105C09 Bile acid BCG9842_B1741 ENOG4105CIS alcohol dehydrogenase BCG9842_B1742 ENOG41082BM Transcriptional regulator, arsr family BCG9842_B1745 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BCG9842_B1748 ENOG4105E5T Major Facilitator Superfamily BCG9842_B1750 ENOG4108A04 Beta-lactamase BCG9842_B1755 ENOG4105DWY Agmatine deiminase BCG9842_B1756 ENOG4105DPN Oligoendopeptidase f BCG9842_B1757 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BCG9842_B1758 ENOG4105E5K Alpha-amylase BCG9842_B1760 ENOG4105C98 muts2 protein BCG9842_B1762 ENOG4105EKQ RNA-directed DNA polymerase BCG9842_B1767 ENOG4107V2S Transcriptional regulator BCG9842_B1769 ENOG4107CUJ Protein of unknown function (DUF2690) BCG9842_B1773 ENOG4105NX3 Membrane BCG9842_B1774 ENOG4105DQ5 transport system permease protein BCG9842_B1775 ENOG4105EHG Permease protein BCG9842_B1776 ENOG4108MES Periplasmic binding protein BCG9842_B1780 ENOG4107R3E Citrate transporter BCG9842_B1782 ENOG4108TN2 lmbE family BCG9842_B1789 ENOG4105CIS alcohol dehydrogenase BCG9842_B1796 ENOG4105H3G oxidoreductase BCG9842_B1803 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BCG9842_B1815 ENOG4108ZJ4 polysaccharide deacetylase BCG9842_B1818 ENOG4107SCK Monooxygenase BCG9842_B1819 ENOG4105KVH Transcriptional regulator BCG9842_B1820 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BCG9842_B1823 ENOG4105JAB phenazine biosynthesis protein, phzf family BCG9842_B1832 ENOG4105D9R oxidoreductase BCG9842_B1833 ENOG4108TZY GntR Family Transcriptional Regulator BCG9842_B1834 ENOG4105KVH Transcriptional regulator BCG9842_B1840 ENOG4105C44 Serine transporter BCG9842_B1843 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BCG9842_B1844 ENOG4105CV1 Transketolase (EC 2.2.1.1) BCG9842_B1847 ENOG4105CMG Carbohydrate kinase BCG9842_B1848 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BCG9842_B1849 ENOG4105XDF Protein of unknown function (DUF1272) BCG9842_B1850 ENOG4105DDN Pentapeptide repeat-containing protein BCG9842_B1855 ENOG4105C37 (CBS) domain BCG9842_B1861 ENOG4105EV4 Multidrug resistance protein mdtH BCG9842_B1863 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) BCG9842_B1872 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BCG9842_B1873 ENOG4105C31 Tryptophanyl-tRNA synthetase BCG9842_B1874 ENOG4108UW5 maltose o-acetyltransferase BCG9842_B1875 ENOG4106UW1 Major Facilitator superfamily BCG9842_B1876 ENOG4105DKQ ROK family BCG9842_B1877 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BCG9842_B1891 ENOG4108PSK reductase BCG9842_B1898 ENOG4108RCM Nitroreductase BCG9842_B1899 ENOG4105KVH Transcriptional regulator BCG9842_B1903 ENOG4108Z66 YbaK ebsC protein BCG9842_B1905 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BCG9842_B1907 ENOG4108K8S endonuclease I BCG9842_B1921 ENOG4105DYS nad(p)h dehydrogenase (quinone) BCG9842_B1923 ENOG4105CRW Short chain fatty acid transporter BCG9842_B1927 ENOG4105CZM Major Facilitator BCG9842_B1928 ENOG4107MII Sugar-specific transcriptional regulator TrmB BCG9842_B1931 ENOG4108ISG Major Facilitator BCG9842_B1933 ENOG4105PNM synthesis protein BCG9842_B1934 ENOG4108VXD carboxy-peptidase BCG9842_B1977 ENOG4108IG5 Transcriptional regulator BCG9842_B1979 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BCG9842_B1984 ENOG410874W AraC family transcriptional regulator BCG9842_B1985 ENOG41082W1 Cupin 2, conserved barrel domain protein BCG9842_B1988 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BCG9842_B1989 ENOG4108JQ1 Dehydrogenase BCG9842_B1993 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BCG9842_B1996 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BCG9842_B1998 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 BCG9842_B1999 ENOG4108U05 Transcriptional regulator BCG9842_B2002 ENOG4105BZU Histidine kinase BCG9842_B2003 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BCG9842_B2007 ENOG4105JQZ Methyltransferase BCG9842_B2011 ENOG4105K6H D-cysteine desulfhydrase BCG9842_B2014 ENOG4105C0R drug resistance transporter emrb qaca subfamily BCG9842_B2016 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BCG9842_B2023 ENOG4105C19 ABC transporter BCG9842_B2025 ENOG4105DNP FAD linked oxidase domain protein BCG9842_B2032 ENOG41062D9 Histidine kinase BCG9842_B2033 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BCG9842_B2042 ENOG4108YXU transcriptional regulator AsnC family BCG9842_B2043 ENOG4105CHR reductase BCG9842_B2044 ENOG4108IG5 Transcriptional regulator BCG9842_B2045 ENOG4107P5I polyketide synthase BCG9842_B2056 ENOG4105EGI Transcriptional regulator BCG9842_B2059 ENOG41085FC arsR family transcriptional regulator BCG9842_B2060 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase BCG9842_B2061 ENOG4105D6J arsenicaL-resistance protein BCG9842_B2065 ENOG4105DIK (ABC) transporter BCG9842_B2066 ENOG4105CC5 ABC transporter BCG9842_B2067 ENOG4105DSE periplasmic solute binding protein BCG9842_B2068 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BCG9842_B2070 ENOG4107VMI polysaccharide deacetylase BCG9842_B2071 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BCG9842_B2072 ENOG4108TWJ NADH dehydrogenase subunit 5 BCG9842_B2075 ENOG4105CVP deoxyribo-dipyrimidine photolyase BCG9842_B2076 ENOG4108606 TspO/MBR family BCG9842_B2079 ENOG4105F6J Alpha beta hydrolase fold BCG9842_B2084 ENOG41090MY MarR family Transcriptional regulator BCG9842_B2089 ENOG4105CHJ isochorismatase hydrolase BCG9842_B2091 ENOG4105CGH 5'-nucleotidase BCG9842_B2094 ENOG4106A3M Cytochrome p-450 BCG9842_B2102 ENOG4108Q8B Spore germination protein BCG9842_B2103 ENOG4108NHD germination protein BCG9842_B2105 ENOG4105II7 pyrroline-5-carboxylate reductase BCG9842_B2106 ENOG4105CUB amino acid BCG9842_B2107 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BCG9842_B2110 ENOG41075H3 AraC family transcriptional regulator BCG9842_B2115 ENOG4105BZU Histidine kinase BCG9842_B2117 ENOG4108B31 Spore germination protein BCG9842_B2120 ENOG4108IMY Transcriptional regulator BCG9842_B2121 ENOG4105HDK L-asparaginase BCG9842_B2122 ENOG4108IJ0 Aspartate ammonia-lyase BCG9842_B2124 ENOG4105E2A Dehydrogenase BCG9842_B2130 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BCG9842_B2138 ENOG4105DWD nucleoside recognition domain protein BCG9842_B2142 ENOG4105FDT acyl-CoA dehydrogenase BCG9842_B2144 ENOG4108ZHR arsR family transcriptional regulator BCG9842_B2145 ENOG4106N3A copper homeostasis protein cutc BCG9842_B2147 ENOG4107258 Transcriptional regulator BCG9842_B2148 ENOG4105P4J Allophanate hydrolase, subunit 1 BCG9842_B2154 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BCG9842_B2155 ENOG4107RF6 penicillin-binding protein BCG9842_B2161 ENOG4105BZU Histidine kinase BCG9842_B2164 ENOG4108VJ1 Transcriptional regulator (CarD family BCG9842_B2176 ENOG4108IQI permease BCG9842_B2179 ENOG410635A Membrane BCG9842_B2189 ENOG4108PCN EamA-like transporter family BCG9842_B2190 ENOG4105E09 nadh pyrophosphatase BCG9842_B2192 ENOG4108XET gCN5-related N-acetyltransferase BCG9842_B2199 ENOG4105C19 ABC transporter BCG9842_B2200 ENOG4105CMR udp-glucose 4-epimerase BCG9842_B2201 ENOG4105WEC Molybdate metabolism regulator BCG9842_B2202 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BCG9842_B2205 ENOG4105FS7 Transcriptional regulator BCG9842_B2206 ENOG4108TVJ Nitroreductase BCG9842_B2210 ENOG4108IBT Inherit from COG: transposase BCG9842_B2214 ENOG4106BHF BCG9842_B2215 ENOG41090AA BCG9842_B2221 ENOG4105C8Y Acetylornithine aminotransferase BCG9842_B2227 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BCG9842_B2232 ENOG4105KNA -acetyltransferase BCG9842_B2236 ENOG4105VMP Transcriptional regulator BCG9842_B2238 ENOG4105G6Z alkaline phosphatase BCG9842_B2239 ENOG4107RBI VanW family BCG9842_B2242 ENOG4105ECK Fatty Acid Desaturase BCG9842_B2248 ENOG4107258 Transcriptional regulator BCG9842_B2250 ENOG4105II7 pyrroline-5-carboxylate reductase BCG9842_B2254 ENOG4105YVS arsR family transcriptional regulator BCG9842_B2256 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BCG9842_B2259 ENOG41061GT Aldolase BCG9842_B2261 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) BCG9842_B2262 ENOG4105DKT Transcriptional regulator BCG9842_B2263 ENOG4105C2J ABC transporter BCG9842_B2264 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane BCG9842_B2266 ENOG4105D4B ABC, transporter BCG9842_B2273 ENOG41069ER domain protein BCG9842_B2280 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BCG9842_B2281 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BCG9842_B2286 ENOG41082JN Transcriptional regulator BCG9842_B2287 ENOG4105EYF MMPL domain protein BCG9842_B2288 ENOG4105C5H ABC transporter BCG9842_B2289 ENOG4105E0M Sulfatase BCG9842_B2290 ENOG4108ZCF integral membrane protein BCG9842_B2294 ENOG4107VMI polysaccharide deacetylase BCG9842_B2297 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BCG9842_B2298 ENOG4105C6T cysteine synthase BCG9842_B2299 ENOG4107VC0 DNA alkylation repair enzyme BCG9842_B2302 ENOG4108W0I acetyltransferase BCG9842_B2306 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BCG9842_B2311 ENOG4105D7T ABC transporter BCG9842_B2312 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BCG9842_B2313 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BCG9842_B2316 ENOG4105C02 permease BCG9842_B2325 ENOG4105DVE abc transporter atp-binding protein BCG9842_B2328 ENOG4108ZMI UPF0477 protein BCG9842_B2331 ENOG4105CHM Aminotransferase BCG9842_B2339 ENOG41089UC methyltransferase, type 11 BCG9842_B2342 ENOG4107BMA Transglycosylase associated protein BCG9842_B2346 ENOG4106K7D Major facilitator family transporter BCG9842_B2347 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BCG9842_B2359 ENOG4105EPR degv family BCG9842_B2360 ENOG4105DPN Oligoendopeptidase f BCG9842_B2366 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BCG9842_B2367 ENOG4105BZU Histidine kinase BCG9842_B2368 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BCG9842_B2369 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BCG9842_B2375 ENOG4105KRN Transcriptional regulator, abrb family BCG9842_B2405 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BCG9842_B2421 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BCG9842_B2428 ENOG4107SET aldo keto reductase BCG9842_B2431 ENOG4105DTQ mandelate racemase muconate lactonizing BCG9842_B2434 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BCG9842_B2436 ENOG4107T5V SNARE associated Golgi BCG9842_B2437 ENOG4105DCI Phosphohydrolase BCG9842_B2438 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BCG9842_B2444 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein BCG9842_B2446 ENOG41080HI glycine oxidase BCG9842_B2447 ENOG4105CTU Proline racemase BCG9842_B2449 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BCG9842_B2450 ENOG4105C26 Dehydrogenase BCG9842_B2451 ENOG4105BZG amino acid carrier protein BCG9842_B2455 ENOG4108M1A Chitin-binding protein BCG9842_B2466 ENOG4105C9U ATP-dependent DNA helicase RecQ BCG9842_B2469 ENOG4105EEM helicase BCG9842_B2470 ENOG4105KEG ribosomal-protein-alanine acetyltransferase BCG9842_B2475 ENOG4108Z7F N-acetyltransferase BCG9842_B2480 ENOG4105MSB protein, conserved in bacteria BCG9842_B2481 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BCG9842_B2484 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BCG9842_B2486 ENOG41087PP glycosyltransferase MGT family BCG9842_B2487 ENOG4108M1A Chitin-binding protein BCG9842_B2490 ENOG41082BV acetyltransferase BCG9842_B2491 ENOG4105E66 phosphoriboisomerase A BCG9842_B2494 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BCG9842_B2496 ENOG4108IJ7 Glycine betaine BCG9842_B2497 ENOG4107SQ8 Glycine betaine BCG9842_B2505 ENOG4105RHY Pfam:UPF0157 BCG9842_B2506 ENOG4105E1F short-chain dehydrogenase reductase BCG9842_B2508 ENOG4107RUY (E1 component), alpha subunit BCG9842_B2510 ENOG4107QKR Dehydrogenase BCG9842_B2514 ENOG41062ES Transcriptional regulator BCG9842_B2517 ENOG4105E98 transcriptional regulator DeoR family BCG9842_B2521 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BCG9842_B2525 ENOG4107Z3H Transcriptional regulator, TetR family BCG9842_B2526 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) BCG9842_B2527 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) BCG9842_B2533 ENOG4105MSI germination protein ypeb BCG9842_B2543 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BCG9842_B2544 ENOG4105FDR Membrane BCG9842_B2545 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BCG9842_B2546 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) BCG9842_B2550 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic BCG9842_B2552 ENOG4108IUM Glycogen debranching enzyme BCG9842_B2555 ENOG4105DY8 decarboxylase BCG9842_B2558 ENOG4107WD8 ABC transporter, permease BCG9842_B2562 ENOG4105BZU Histidine kinase BCG9842_B2563 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BCG9842_B2564 ENOG4105U0R haloacid dehalogenase-like hydrolase BCG9842_B2569 ENOG4107VFR oxidoreductase BCG9842_B2574 ENOG41087PP glycosyltransferase MGT family BCG9842_B2575 ENOG41087PP glycosyltransferase MGT family BCG9842_B2584 ENOG4105PKS Excinuclease abc c subunit domain protein BCG9842_B2586 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BCG9842_B2592 ENOG4105KWG Pfam:DUF1696 BCG9842_B2593 ENOG4108NRW Phospholipase, patatin family BCG9842_B2598 ENOG4108XI2 Domain of unknown function (DUF1963) BCG9842_B2603 ENOG4108Z4K mutator MutT protein BCG9842_B2604 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BCG9842_B2607 ENOG4105FCD Major Facilitator BCG9842_B2611 ENOG4105M6F mutator MutT protein BCG9842_B2612 ENOG4105EGD dinuclear metal center protein, YbgI family BCG9842_B2616 ENOG4107Y9U Membrane BCG9842_B2622 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BCG9842_B2625 ENOG4107Y80 Major Facilitator superfamily BCG9842_B2628 ENOG4107HNS degV-like protein BCG9842_B2634 ENOG4105CJN penicillin-binding protein BCG9842_B2635 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BCG9842_B2636 ENOG4105CB2 alcohol dehydrogenase BCG9842_B2655 ENOG4108HGU Histidine kinase BCG9842_B2658 ENOG4108JJB ABC transporter BCG9842_B2664 ENOG4107RF6 penicillin-binding protein BCG9842_B2665 ENOG4105BZU Histidine kinase BCG9842_B2666 ENOG410667J hydrolase BCG9842_B2684 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BCG9842_B2685 ENOG4105XSJ toxin secretion phage lysis holin BCG9842_B2700 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BCG9842_B2715 ENOG4105D7V transposase BCG9842_B2716 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein BCG9842_B2718 ENOG4105D7V transposase BCG9842_B2724 ENOG4105KRN Transcriptional regulator, abrb family BCG9842_B2729 ENOG4105D7V transposase BCG9842_B2734 ENOG4105VTR Integrase BCG9842_B2739 ENOG4105ETU transcriptional activator (TenA BCG9842_B2741 ENOG4105CPF Cell wall formation (By similarity) BCG9842_B2743 ENOG4105D6E homoserine dehydrogenase BCG9842_B2751 ENOG4105CPC Aldo Keto reductase BCG9842_B2752 ENOG4106NZI LysR family Transcriptional regulator BCG9842_B2757 ENOG4105DK7 lysyl-tRNA synthetase BCG9842_B2759 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein BCG9842_B2761 ENOG4108V4B ThiJ pfpI BCG9842_B2763 ENOG410900G Protein of unknown function (DUF421) BCG9842_B2765 ENOG4105CPQ Dehydrogenase BCG9842_B2778 ENOG4105KVH Transcriptional regulator BCG9842_B2779 ENOG4105CHR reductase BCG9842_B2781 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BCG9842_B2788 ENOG41075H3 AraC family transcriptional regulator BCG9842_B2792 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BCG9842_B2795 ENOG4105T9C HD domain BCG9842_B2798 ENOG4105DZ1 carboxypeptidase BCG9842_B2805 ENOG4105DQ6 Transposase BCG9842_B2806 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BCG9842_B2807 ENOG4107QX3 carboxylase BCG9842_B2808 ENOG4105E39 Enoyl-CoA hydratase BCG9842_B2809 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BCG9842_B2810 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BCG9842_B2811 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BCG9842_B2812 ENOG4105C1G acyl-Coa dehydrogenase BCG9842_B2815 ENOG4107Z3H Transcriptional regulator, TetR family BCG9842_B2817 ENOG4105CJ1 ABC, transporter BCG9842_B2819 ENOG4105DIN metallophosphoesterase BCG9842_B2821 ENOG4107RF6 penicillin-binding protein BCG9842_B2822 ENOG4107RF6 penicillin-binding protein BCG9842_B2826 ENOG4107RVG penicillin-binding protein BCG9842_B2833 ENOG4107VMI polysaccharide deacetylase BCG9842_B2836 ENOG4108IMY Transcriptional regulator BCG9842_B2847 ENOG4108SC4 )-transporter BCG9842_B2848 ENOG4105IIU Aminopeptidase BCG9842_B2850 ENOG4105FJR Lmbe family BCG9842_B2853 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BCG9842_B2854 ENOG4108IAJ Nad-dependent epimerase dehydratase BCG9842_B2855 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BCG9842_B2856 ENOG4107QQG Dehydrogenase BCG9842_B2857 ENOG4108W0I acetyltransferase BCG9842_B2870 ENOG4105CHR reductase BCG9842_B2872 ENOG4105W8Z 4'-phosphopantetheinyl transferase BCG9842_B2881 ENOG4105EJ9 Membrane BCG9842_B2883 ENOG4105KRN Transcriptional regulator, abrb family BCG9842_B2888 ENOG4105CIN aminoacyl-histidine dipeptidase BCG9842_B2896 ENOG4107RA9 decarboxylase BCG9842_B2897 ENOG4108I0C methyltransferase BCG9842_B2899 ENOG41088CC tellurite resistance protein tehB BCG9842_B2900 ENOG4105C1J atp-dependent rna helicase BCG9842_B2902 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BCG9842_B2905 ENOG4108INS Transcriptional regulator BCG9842_B2906 ENOG4105C7B Threonine dehydratase BCG9842_B2907 ENOG4107STF Involved in phosphonate degradation (By similarity) BCG9842_B2908 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BCG9842_B2909 ENOG4105RD7 BadF BadG BcrA BcrD BCG9842_B2914 ENOG4105F32 YngK protein BCG9842_B2921 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) BCG9842_B2928 ENOG4108JCI Transcriptional regulator BCG9842_B2932 ENOG4105BZ1 (ABC) transporter BCG9842_B2933 ENOG4105BZ1 (ABC) transporter BCG9842_B2936 ENOG4108RPX mosc domain containing protein BCG9842_B2937 ENOG4105DND Transcriptional regulator BCG9842_B2939 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BCG9842_B2940 ENOG4107V2S Transcriptional regulator BCG9842_B2946 ENOG41068WN BCG9842_B2948 ENOG4105C1Q protoporphyrinogen oxidase BCG9842_B2953 ENOG4105WCN acetyltransferase BCG9842_B2958 ENOG4105EYF MMPL domain protein BCG9842_B2960 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BCG9842_B2964 ENOG4108Y4K DNA-binding transcriptional activator BCG9842_B2966 ENOG41081I9 integral membrane protein BCG9842_B2972 ENOG4105C19 ABC transporter BCG9842_B2973 ENOG4105C22 threonyL-tRNA synthetase BCG9842_B2974 ENOG4105FE9 pseudouridine synthase BCG9842_B2979 ENOG4105BZG amino acid carrier protein BCG9842_B2983 ENOG4105K70 DNA-binding protein BCG9842_B2986 ENOG4105C0R drug resistance transporter emrb qaca subfamily BCG9842_B2987 ENOG4105WQT MbtH domain protein BCG9842_B2988 ENOG4105CEY Amp-dependent synthetase and ligase BCG9842_B2989 ENOG4105WQI isochorismatase BCG9842_B2990 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BCG9842_B2991 ENOG4105E4F Isochorismate synthase BCG9842_B2992 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BCG9842_B2993 ENOG4105FCD Major Facilitator BCG9842_B2998 ENOG4105EYH Exonuclease BCG9842_B2999 ENOG4107RFY SbcCD D subunit BCG9842_B3002 ENOG4105E39 Enoyl-CoA hydratase BCG9842_B3003 ENOG4105N14 lysine exporter protein LysE YggA BCG9842_B3005 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BCG9842_B3006 ENOG4105C1G acyl-Coa dehydrogenase BCG9842_B3008 ENOG4105CR4 methylisocitrate lyase BCG9842_B3009 ENOG4105DXD 2-methylcitrate dehydratase BCG9842_B3011 ENOG4105W8X HesB YadR YfhF-family protein BCG9842_B3012 ENOG4105CZM Major Facilitator BCG9842_B3013 ENOG4105BZ4 penicillin-binding protein BCG9842_B3023 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BCG9842_B3031 ENOG4105SZ6 Thioredoxin BCG9842_B3032 ENOG410841Q phosphoesterase PA-phosphatase related protein BCG9842_B3042 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BCG9842_B3043 ENOG4108JUB Transcriptional regulator BCG9842_B3044 ENOG4108TSC N-acetyltransferase BCG9842_B3045 ENOG4107S4Y M20 DapE family protein YgeY BCG9842_B3048 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BCG9842_B3055 ENOG4105C37 (CBS) domain BCG9842_B3062 ENOG4105E90 ABC transporter BCG9842_B3063 ENOG4108IJ8 ABC transporter BCG9842_B3069 ENOG4108YV3 Protein of unknown function (DUF2711) BCG9842_B3071 ENOG4105C6Z Gluconate BCG9842_B3072 ENOG4105CMG Carbohydrate kinase BCG9842_B3076 ENOG4107ZY0 Phenazine biosynthesis-like protein BCG9842_B3077 ENOG4106KNT transcriptional regulator BCG9842_B3078 ENOG4105WH1 Two component transcriptional regulator luxr family BCG9842_B3079 ENOG4105BZU Histidine kinase BCG9842_B3080 ENOG4105D8X mechanosensitive ion channel BCG9842_B3086 ENOG4105F0I Aminotransferase BCG9842_B3087 ENOG4108MES Periplasmic binding protein BCG9842_B3088 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BCG9842_B3091 ENOG4105CAQ asparagine synthetase BCG9842_B3092 ENOG4107Y70 Heat shock protein BCG9842_B3093 ENOG4108KF3 Electron transport protein SCO1 SenC BCG9842_B3096 ENOG4108RCR degv family BCG9842_B3098 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BCG9842_B3100 ENOG4108UT2 hemolysin iii BCG9842_B3101 ENOG4105E9Q Acyl-transferase BCG9842_B3103 ENOG4107RVG penicillin-binding protein BCG9842_B3109 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 BCG9842_B3115 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BCG9842_B3116 ENOG4105VMP Transcriptional regulator BCG9842_B3118 ENOG4105KD7 acetyltransferase BCG9842_B3122 ENOG4105CY2 Citrate transporter BCG9842_B3123 ENOG4107XGZ Hydrolase BCG9842_B3126 ENOG4108EF6 Proline imino-peptidase BCG9842_B3127 ENOG4105C8J )-transporter BCG9842_B3128 ENOG4105C5S asparaginyl-tRNA synthetase BCG9842_B3131 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BCG9842_B3135 ENOG4105C75 arginyL-tRNA synthetase BCG9842_B3136 ENOG4107YX5 Pfam:DUF548 BCG9842_B3142 ENOG4108UUM single-stranded DNA-binding protein BCG9842_B3145 ENOG4105C5H ABC transporter BCG9842_B3154 ENOG4105MCT stage V sporulation protein S BCG9842_B3161 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BCG9842_B3162 ENOG4108IFG nitrite reductase, (NAD(P)H) BCG9842_B3163 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BCG9842_B3164 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BCG9842_B3165 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BCG9842_B3166 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BCG9842_B3172 ENOG4108ZAF Molybdopterin BCG9842_B3173 ENOG4105CVM Molybdenum cofactor synthesis domain protein BCG9842_B3174 ENOG4105D06 uba thif-type nad fad binding protein BCG9842_B3175 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BCG9842_B3176 ENOG4107V6Q Cyclic nucleotide-binding domain BCG9842_B3178 ENOG4105R3A Nitrate reductase BCG9842_B3179 ENOG4108IUE nitrate reductase beta subunit BCG9842_B3181 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BCG9842_B3184 ENOG4108V06 Glutathione peroxidase BCG9842_B3186 ENOG4105CNW domain protein BCG9842_B3188 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) BCG9842_B3190 ENOG4105EMN RNA polymerase sigma factor BCG9842_B3191 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BCG9842_B3193 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BCG9842_B3194 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BCG9842_B3198 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BCG9842_B3203 ENOG4105KBJ sporulation protein ytfj BCG9842_B3218 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) BCG9842_B3220 ENOG4106PAW secretion accessory protein EsaA YueB BCG9842_B3224 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BCG9842_B3230 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BCG9842_B3231 ENOG4108JYZ YitT family BCG9842_B3232 ENOG41087PP glycosyltransferase MGT family BCG9842_B3235 ENOG4107RBS Methyltransferase BCG9842_B3236 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BCG9842_B3238 ENOG4105D94 Major Facilitator Superfamily BCG9842_B3239 ENOG41082F9 transcriptional regulator BCG9842_B3240 ENOG4108X4Q Hydrolase BCG9842_B3242 ENOG4108ZRV stage ii sporulation protein p BCG9842_B3249 ENOG4108VXD carboxy-peptidase BCG9842_B3251 ENOG4108ZRV stage ii sporulation protein p BCG9842_B3253 ENOG4108Z7R Chaperone CsaA BCG9842_B3259 ENOG4105C37 (CBS) domain BCG9842_B3260 ENOG4105SXS Protein of unknown function (DUF456) BCG9842_B3264 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BCG9842_B3266 ENOG4108S4H thioesterase Superfamily protein BCG9842_B3268 ENOG4108PJD permease BCG9842_B3271 ENOG4107T5V SNARE associated Golgi BCG9842_B3275 ENOG4105CVJ phosphoglycerate mutase BCG9842_B3280 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BCG9842_B3282 ENOG4105K4T epimerase BCG9842_B3284 ENOG4105DSE periplasmic solute binding protein BCG9842_B3286 ENOG4105CKI cobalamin synthesis protein BCG9842_B3287 ENOG4107QM2 Aldo Keto reductase BCG9842_B3288 ENOG4105VMI -acetyltransferase BCG9842_B3291 ENOG4105DEN Luciferase family BCG9842_B3294 ENOG4108WPJ Ferritin-like domain BCG9842_B3295 ENOG4108K88 Membrane BCG9842_B3298 ENOG4105C8Q Methyl-accepting chemotaxis BCG9842_B3303 ENOG4107XZQ multidrug resistance protein BCG9842_B3304 ENOG4105CPC Aldo Keto reductase BCG9842_B3305 ENOG4105YVS arsR family transcriptional regulator BCG9842_B3307 ENOG4105KRN Transcriptional regulator, abrb family BCG9842_B3314 ENOG4105EFC phage portal protein HK97 family BCG9842_B3337 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BCG9842_B3338 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BCG9842_B3340 ENOG4105YWU small acid-soluble spore protein BCG9842_B3341 ENOG4108WBH protein TIM barrel BCG9842_B3344 ENOG4105CEY Amp-dependent synthetase and ligase BCG9842_B3345 ENOG4105DUU IucA IucC family protein BCG9842_B3347 ENOG4105VRR gCN5-related N-acetyltransferase BCG9842_B3348 ENOG4105KT7 mgtC SapB transporter BCG9842_B3352 ENOG4108KGH TRANSCRIPTIONal BCG9842_B3357 ENOG4105D6E homoserine dehydrogenase BCG9842_B3361 ENOG4108ZJ4 polysaccharide deacetylase BCG9842_B3362 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BCG9842_B3363 ENOG4108VQJ O-methyltransferase BCG9842_B3365 ENOG4105BZU Histidine kinase BCG9842_B3366 ENOG4105EFI regulatoR BCG9842_B3367 ENOG4105BZ1 (ABC) transporter BCG9842_B3378 ENOG4108UT6 Transferase hexapeptide repeat containing protein BCG9842_B3380 ENOG4105K64 Glycosyl transferase, family 2 BCG9842_B3382 ENOG4108JJ8 (ABC) transporter BCG9842_B3383 ENOG4108JJ9 ABC, transporter BCG9842_B3384 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BCG9842_B3385 ENOG4105C4M (Ubiquinol oxidase) subunit I BCG9842_B3392 ENOG4107XZA Glycosyl transferase family 2 BCG9842_B3395 ENOG4105CJ1 ABC, transporter BCG9842_B3396 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BCG9842_B3397 ENOG4105CEY Amp-dependent synthetase and ligase BCG9842_B3401 ENOG4105FAW cDP-glucose 4,6-dehydratase BCG9842_B3402 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase BCG9842_B3406 ENOG4105SKE transcriptional Regulator LysR family BCG9842_B3408 ENOG4105C32 Amino acid ABC transporter (Permease) BCG9842_B3409 ENOG4108IV0 ABC, transporter BCG9842_B3410 ENOG4105C0Z ABC transporter BCG9842_B3412 ENOG4105CKI cobalamin synthesis protein BCG9842_B3415 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BCG9842_B3416 ENOG4106F5Q Membrane BCG9842_B3418 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BCG9842_B3420 ENOG4108TVJ Nitroreductase BCG9842_B3421 ENOG4107ZXU DSBA oxidoreductase BCG9842_B3422 ENOG4108Z40 Transcriptional regulator BCG9842_B3423 ENOG4105GZI Transcriptional regulator BCG9842_B3424 ENOG4107RT3 EamA-like transporter family BCG9842_B3425 ENOG4105KTB nuclear export factor GLE1 BCG9842_B3426 ENOG4108T5E Copper resistance protein BCG9842_B3435 ENOG4107R16 Multicopper oxidase BCG9842_B3437 ENOG4107RAQ aminopeptidase BCG9842_B3443 ENOG4108IBT Inherit from COG: transposase BCG9842_B3446 ENOG4105DQ6 Transposase BCG9842_B3449 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BCG9842_B3450 ENOG4105D9N nucleoside BCG9842_B3452 ENOG4107RHR regulatoR BCG9842_B3455 ENOG4105K8R UPF0145 protein BCG9842_B3456 ENOG410849A acetyltransferase, (GNAT) family BCG9842_B3464 ENOG4105C0X amino acid BCG9842_B3467 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BCG9842_B3470 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BCG9842_B3474 ENOG41068WN BCG9842_B3479 ENOG4105CYC Transferase BCG9842_B3480 ENOG4105DY9 regulatoR BCG9842_B3482 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BCG9842_B3483 ENOG4105C6X Major Facilitator BCG9842_B3487 ENOG4105C7B Threonine dehydratase BCG9842_B3489 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BCG9842_B3491 ENOG4105C7K acetolactate synthase BCG9842_B3492 ENOG4105CM2 brancheD-chain amino acid aminotransferase BCG9842_B3493 ENOG4105CHR reductase BCG9842_B3494 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BCG9842_B3499 ENOG4105H67 Protein of unknown function (DUF421) BCG9842_B3500 ENOG4105X5K response regulator receiver protein BCG9842_B3502 ENOG4105C8J )-transporter BCG9842_B3506 ENOG4105C6T cysteine synthase BCG9842_B3507 ENOG4105EU0 Major facilitator Superfamily BCG9842_B3508 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BCG9842_B3510 ENOG4105DXI Major Facilitator superfamily BCG9842_B3512 ENOG4105U3E Transcriptional regulator BCG9842_B3513 ENOG4105CSR polyphosphate kinase 2 BCG9842_B3516 ENOG4105E09 nadh pyrophosphatase BCG9842_B3517 ENOG4105FVX BCG9842_B3529 ENOG4105C6K Malic enzyme BCG9842_B3530 ENOG4108IJ0 Aspartate ammonia-lyase BCG9842_B3532 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BCG9842_B3536 ENOG4105CJ1 ABC, transporter BCG9842_B3544 ENOG4106BRA Membrane BCG9842_B3548 ENOG4107JM4 Tetratricopeptide repeat BCG9842_B3551 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BCG9842_B3552 ENOG4107QIV Cytochrome c biogenesis protein BCG9842_B3556 ENOG4105EC3 peptidase S51, dipeptidase E BCG9842_B3557 ENOG4107QJQ Mate efflux family protein BCG9842_B3561 ENOG4105C9Q fumarate hydratase class II BCG9842_B3563 ENOG4105VUF Transcriptional regulator BCG9842_B3564 ENOG4105DFD Na H antiporter BCG9842_B3567 ENOG4108PJD permease BCG9842_B3568 ENOG4105CKI cobalamin synthesis protein BCG9842_B3571 ENOG4105PGM cation diffusion facilitator family transporter BCG9842_B3575 ENOG4105CAQ asparagine synthetase BCG9842_B3577 ENOG4105K56 Transcriptional regulator BCG9842_B3579 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) BCG9842_B3581 ENOG4105CVJ phosphoglycerate mutase BCG9842_B3589 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component BCG9842_B3591 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BCG9842_B3592 ENOG4105DUM transcriptional regulator, lysR family BCG9842_B3597 ENOG4107QZ7 Cellulose synthase catalytic subunit BCG9842_B3598 ENOG4105KAC Antibiotic biosynthesis monooxygenase BCG9842_B3604 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BCG9842_B3605 ENOG4105CPU Monooxygenase BCG9842_B3606 ENOG4105KTQ flagellar basal-body rod protein BCG9842_B3607 ENOG4105FZW flagellar biosynthesis regulator FlhF BCG9842_B3608 ENOG4105D7B Flagellar biosynthesis protein flha BCG9842_B3609 ENOG4105D00 flagellar biosynthetic protein flhB BCG9842_B3611 ENOG4105VS8 Flagellar biosynthetic protein fliq BCG9842_B3612 ENOG4105CN7 Flagellar biosynthetic protein FliP BCG9842_B3614 ENOG4105DD5 Flagellar motor switch protein BCG9842_B3615 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BCG9842_B3617 ENOG4105E4C Lytic transglycosylase catalytic BCG9842_B3618 ENOG4105I03 Flagellin BCG9842_B3620 ENOG4105DQ6 Transposase BCG9842_B3623 ENOG4107R88 Chemotaxis protein (CheV) BCG9842_B3626 ENOG4105BZE flagellar hook protein, FlgE BCG9842_B3632 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BCG9842_B3633 ENOG4107U2N Flagellar M-ring protein BCG9842_B3634 ENOG41075Z6 flagellar hook-basal body complex protein fliE BCG9842_B3635 ENOG4108ZC9 flagellar basal-body rod protein flgc BCG9842_B3636 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BCG9842_B3641 ENOG4105DTJ flagellar hook-associated protein BCG9842_B3642 ENOG4105E1Q flagellar hook-associated protein BCG9842_B3646 ENOG4105BZU Histidine kinase BCG9842_B3649 ENOG4105DD5 Flagellar motor switch protein BCG9842_B3650 ENOG4105CBS Chea signal transduction histidine kinase BCG9842_B3651 ENOG4107YTP response regulator receiver protein BCG9842_B3652 ENOG4105ER2 Ompa motb domain protein BCG9842_B3653 ENOG4107R0U MotA TolQ exbB proton channel BCG9842_B3655 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BCG9842_B3662 ENOG4105DQ6 Transposase BCG9842_B3664 ENOG41080C8 DUF218 domain BCG9842_B3665 ENOG4105H67 Protein of unknown function (DUF421) BCG9842_B3667 ENOG4108Z5V transcriptional regulator, merr family BCG9842_B3668 ENOG4105CN5 Metallo-Beta-Lactamase BCG9842_B3669 ENOG4107RWR Sodium hydrogen exchanger BCG9842_B3671 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BCG9842_B3686 ENOG41081VK Ribonuclease BCG9842_B3690 ENOG4108SZE gCN5-related N-acetyltransferase BCG9842_B3693 ENOG4105CPK Glycosyl transferase (Group 1 BCG9842_B3706 ENOG4106032 Glutathionylspermidine synthase BCG9842_B3711 ENOG4105KHC sulfurtransferase BCG9842_B3713 ENOG4108W0I acetyltransferase BCG9842_B3715 ENOG410890F Dynamin family BCG9842_B3717 ENOG4105DHF Membrane BCG9842_B3718 ENOG4105C2W permease BCG9842_B3721 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BCG9842_B3724 ENOG4105CTD carboxy-peptidase BCG9842_B3725 ENOG4105DVT helicase BCG9842_B3727 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BCG9842_B3739 ENOG4105BZ4 penicillin-binding protein BCG9842_B3742 ENOG4105CSM endonuclease III BCG9842_B3746 ENOG4105YAC BCG9842_B3747 ENOG4105DVT helicase BCG9842_B3754 ENOG4105CPK Glycosyl transferase (Group 1 BCG9842_B3755 ENOG4105FJR Lmbe family BCG9842_B3758 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BCG9842_B3759 ENOG4108JYZ YitT family BCG9842_B3766 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BCG9842_B3767 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BCG9842_B3770 ENOG41068YB TPR repeat-containing protein BCG9842_B3773 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BCG9842_B3774 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BCG9842_B3775 ENOG4105EAH synthase BCG9842_B3777 ENOG4105XXQ heptaprenyl diphosphate synthase component I BCG9842_B3780 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BCG9842_B3786 ENOG41065D1 BCG9842_B3787 ENOG4105S2F BCG9842_B3794 ENOG4107RB3 L-asparaginase BCG9842_B3795 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BCG9842_B3800 ENOG4108S6Z Negative regulator of genetic competence BCG9842_B3801 ENOG4108XDN Transcriptional regulator BCG9842_B3802 ENOG4107RGJ metallophosphoesterase BCG9842_B3804 ENOG4105I7S Abortive infection protein BCG9842_B3805 ENOG4105C9U ATP-dependent DNA helicase RecQ BCG9842_B3808 ENOG4108SAX Membrane BCG9842_B3812 ENOG4108WBT adenosyltransferase BCG9842_B3813 ENOG4105BZU Histidine kinase BCG9842_B3814 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BCG9842_B3815 ENOG4105CRE cytochrome C BCG9842_B3816 ENOG4107TWT Cytochrome c biogenesis protein BCG9842_B3817 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BCG9842_B3818 ENOG4105FE9 pseudouridine synthase BCG9842_B3820 ENOG4108JIC nucleoside recognition domain protein BCG9842_B3821 ENOG4105DZ1 carboxypeptidase BCG9842_B3822 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BCG9842_B3828 ENOG4105BZU Histidine kinase BCG9842_B3829 ENOG4108FPN Integrase BCG9842_B3831 ENOG4105I3N Conserved Protein BCG9842_B3832 ENOG4105BZU Histidine kinase BCG9842_B3835 ENOG4105BZ4 penicillin-binding protein BCG9842_B3836 ENOG4107GRR phosphate transport regulator BCG9842_B3837 ENOG4105CJ3 phosphate transporter BCG9842_B3841 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BCG9842_B3846 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BCG9842_B3849 ENOG4105WH1 Two component transcriptional regulator luxr family BCG9842_B3850 ENOG4105ENE Histidine kinase BCG9842_B3854 ENOG4105DFD Na H antiporter BCG9842_B3860 ENOG4105C8J )-transporter BCG9842_B3861 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BCG9842_B3862 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BCG9842_B3863 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BCG9842_B3865 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BCG9842_B3866 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BCG9842_B3871 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BCG9842_B3874 ENOG4105E0M Sulfatase BCG9842_B3875 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BCG9842_B3878 ENOG4107RVV histidinol phosphate phosphatase, hisj family BCG9842_B3885 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BCG9842_B3892 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BCG9842_B3893 ENOG4108ZP8 Acetolactate synthase small subunit BCG9842_B3894 ENOG4105C7K acetolactate synthase BCG9842_B3895 ENOG4105CM2 brancheD-chain amino acid aminotransferase BCG9842_B3899 ENOG4105KBJ sporulation protein ytfj BCG9842_B3900 ENOG41063Y9 BCG9842_B3901 ENOG4105CZN Potassium uptake protein BCG9842_B3908 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BCG9842_B3916 ENOG4105NQC Flavodoxin BCG9842_B3921 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BCG9842_B3923 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BCG9842_B3924 ENOG4105EA8 2-Nitropropane dioxygenase BCG9842_B3925 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BCG9842_B3933 ENOG4105CJ1 ABC, transporter BCG9842_B3935 ENOG4105CZV ABC transporter BCG9842_B3936 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BCG9842_B3937 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BCG9842_B3938 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BCG9842_B3939 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BCG9842_B3947 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BCG9842_B3948 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BCG9842_B3951 ENOG4105BZU Histidine kinase BCG9842_B3954 ENOG4106DF1 BCG9842_B3956 ENOG41090MY MarR family Transcriptional regulator BCG9842_B3957 ENOG4105BZU Histidine kinase BCG9842_B3959 ENOG4105PXI polysaccharide deacetylase BCG9842_B3961 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BCG9842_B3964 ENOG4105E98 transcriptional regulator DeoR family BCG9842_B3968 ENOG4107RCV ABC transporter, permease BCG9842_B3969 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BCG9842_B3970 ENOG4105C4Y ABC transporter BCG9842_B3976 ENOG4105CHR reductase BCG9842_B3980 ENOG4108Z7G MaoC domain protein dehydratase BCG9842_B3981 ENOG410681C small acid-soluble spore protein BCG9842_B3982 ENOG4105CZN Potassium uptake protein BCG9842_B3984 ENOG4107TS3 membrane protein, TerC BCG9842_B3985 ENOG4108QTI )-transporter BCG9842_B3987 ENOG4106A3R peptidase BCG9842_B3991 ENOG4105JXH GntR family transcriptional regulator BCG9842_B3992 ENOG4105BZU Histidine kinase BCG9842_B3993 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BCG9842_B3996 ENOG4105CQB FAD linked oxidase domain protein BCG9842_B3997 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BCG9842_B3998 ENOG4105K4I Scp-like extracellular BCG9842_B4000 ENOG4108YBP pseudouridine synthase BCG9842_B4002 ENOG4105EYF MMPL domain protein BCG9842_B4003 ENOG410841Q phosphoesterase PA-phosphatase related protein BCG9842_B4004 ENOG4107RUE extracellular solute-binding protein family 1 BCG9842_B4005 ENOG4105D38 putrescine abc transporter BCG9842_B4006 ENOG4105F38 ABC transporter, permease BCG9842_B4007 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BCG9842_B4008 ENOG4105C26 Dehydrogenase BCG9842_B4015 ENOG4105VFR signal peptidase BCG9842_B4016 ENOG4105DZ1 carboxypeptidase BCG9842_B4022 ENOG4105RHA ABC transporter, permease BCG9842_B4023 ENOG4108IUX (ABC) transporter BCG9842_B4029 ENOG4105VZ8 Transcriptional regulator BCG9842_B4031 ENOG4105C7S Dehydrogenase BCG9842_B4052 ENOG4105DDQ anthranilate synthase BCG9842_B4053 ENOG4105CRQ synthase (Component I) BCG9842_B4055 ENOG4105CK7 Sodium proline symporter BCG9842_B4071 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BCG9842_B4073 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BCG9842_B4074 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BCG9842_B4078 ENOG4107TVC Glycosyl transferase, family 2 BCG9842_B4082 ENOG4105K64 Glycosyl transferase, family 2 BCG9842_B4086 ENOG4105EMS pseudouridine synthase BCG9842_B4087 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BCG9842_B4090 ENOG4105MIX Adenylate cyclase BCG9842_B4091 ENOG4108Z18 K06886 hemoglobin BCG9842_B4094 ENOG4105DPN Oligoendopeptidase f BCG9842_B4096 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BCG9842_B4099 ENOG4108ZCF integral membrane protein BCG9842_B4103 ENOG4105UQX Mate efflux family protein BCG9842_B4104 ENOG4108JQ7 (ABC) transporter BCG9842_B4106 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BCG9842_B4107 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BCG9842_B4110 ENOG4105C31 Tryptophanyl-tRNA synthetase BCG9842_B4113 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BCG9842_B4114 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BCG9842_B4119 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BCG9842_B4121 ENOG4108KP7 hydrolase BCG9842_B4123 ENOG41073B9 BCG9842_B4124 ENOG4107AYK membrAne BCG9842_B4126 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BCG9842_B4127 ENOG4105QNR S1 RNA binding domain protein BCG9842_B4131 ENOG4105BZU Histidine kinase BCG9842_B4132 ENOG4105CH6 catalase BCG9842_B4133 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BCG9842_B4134 ENOG4105CAQ asparagine synthetase BCG9842_B4137 ENOG4105C8Y Acetylornithine aminotransferase BCG9842_B4139 ENOG4105ERH Fumarylacetoacetate hydrolase BCG9842_B4152 ENOG4105XVF Competence transcription factor BCG9842_B4154 ENOG4105VEQ Cold shock protein BCG9842_B4158 ENOG4107QP3 malate synthase g BCG9842_B4160 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) BCG9842_B4162 ENOG4105C8Q Methyl-accepting chemotaxis BCG9842_B4163 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BCG9842_B4168 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BCG9842_B4171 ENOG41086D8 Transcriptional regulator BCG9842_B4172 ENOG4108AEY RNA polymerase sigma factor BCG9842_B4174 ENOG4107TVP HD domain protein BCG9842_B4175 ENOG4107RN3 metallophosphoesterase BCG9842_B4176 ENOG4105ENX hydrolase BCG9842_B4183 ENOG4105CEY Amp-dependent synthetase and ligase BCG9842_B4185 ENOG4105DF9 Lipoate-protein, ligase BCG9842_B4186 ENOG4108RQ5 Beta-lactamase domain-containing protein BCG9842_B4187 ENOG4106AXD BCG9842_B4193 ENOG4105ECB domain protein BCG9842_B4193 ENOG4105ECB domain protein BCG9842_B4200 ENOG4105C1Q protoporphyrinogen oxidase BCG9842_B4201 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BCG9842_B4203 ENOG4105BZ4 penicillin-binding protein BCG9842_B4204 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BCG9842_B4205 ENOG4105CKV Membrane BCG9842_B4206 ENOG410905X membrane-flanked domain protein BCG9842_B4214 ENOG4105CKV Membrane BCG9842_B4215 ENOG410905X membrane-flanked domain protein BCG9842_B4221 ENOG4105K59 histidine triad (HIT) protein BCG9842_B4226 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BCG9842_B4227 ENOG4105EEM helicase BCG9842_B4230 ENOG4105EMN RNA polymerase sigma factor BCG9842_B4232 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BCG9842_B4235 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BCG9842_B4236 ENOG41067QW Transcriptional regulator BCG9842_B4237 ENOG4105F0F Oxalate decarboxylase BCG9842_B4241 ENOG4108MUZ hydrolase BCG9842_B4247 ENOG410829K Lysine exporter protein (Lyse ygga) BCG9842_B4250 ENOG4106D4I domain protein BCG9842_B4251 ENOG4107VRP DNA repair exonuclease BCG9842_B4255 ENOG4107QHE Choloylglycine hydrolase BCG9842_B4258 ENOG4105DJ2 Major Facilitator Superfamily BCG9842_B4266 ENOG4105BZU Histidine kinase BCG9842_B4267 ENOG4105BZU Histidine kinase BCG9842_B4268 ENOG4108MJI response regulator BCG9842_B4270 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BCG9842_B4272 ENOG4105WN5 stage II sporulation protein BCG9842_B4294 ENOG4105CMT Dihydroxyacetone kinase BCG9842_B4296 ENOG4105CMT Dihydroxyacetone kinase BCG9842_B4298 ENOG4105WAB arsR family transcriptional regulator BCG9842_B4299 ENOG4105F27 Major Facilitator BCG9842_B4302 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BCG9842_B4315 ENOG4105F6J Alpha beta hydrolase fold BCG9842_B4320 ENOG4105D9U N-acetyltransferase BCG9842_B4325 ENOG4105C0R drug resistance transporter emrb qaca subfamily BCG9842_B4330 ENOG4105CDU Replicative dna helicase BCG9842_B4341 ENOG4105EKQ RNA-directed DNA polymerase BCG9842_B4345 ENOG4108MRH transcriptional regulatory protein BCG9842_B4347 ENOG4105CSH Transporter BCG9842_B4359 ENOG4108IBT Inherit from COG: transposase BCG9842_B4363 ENOG4105DQ6 Transposase BCG9842_B4370 ENOG4107SFI Major Facilitator superfamily BCG9842_B4371 ENOG4105D06 uba thif-type nad fad binding protein BCG9842_B4374 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase BCG9842_B4382 ENOG4108JQ7 (ABC) transporter BCG9842_B4383 ENOG4105C3U ABC transporter BCG9842_B4384 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BCG9842_B4387 ENOG4105CIF Ornithine Cyclodeaminase BCG9842_B4388 ENOG4105CTU Proline racemase BCG9842_B4392 ENOG4105DER m42 family BCG9842_B4396 ENOG4105CGU Enoyl-CoA hydratase BCG9842_B4401 ENOG4105CHH sulfate transporter BCG9842_B4403 ENOG4105CEY Amp-dependent synthetase and ligase BCG9842_B4404 ENOG4105D4P Coproporphyrinogen iii oxidase BCG9842_B4405 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BCG9842_B4406 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein BCG9842_B4409 ENOG4107FQX Alpha-acetolactate decarboxylase BCG9842_B4419 ENOG4105WH1 Two component transcriptional regulator luxr family BCG9842_B4420 ENOG4105BZU Histidine kinase BCG9842_B4425 ENOG410839P BCG9842_B4428 ENOG4105CDA abc transporter atp-binding protein BCG9842_B4429 ENOG4105DRP amino acid AbC transporter BCG9842_B4431 ENOG4105BZ1 (ABC) transporter BCG9842_B4432 ENOG4105BZ1 (ABC) transporter BCG9842_B4434 ENOG4105C26 Dehydrogenase BCG9842_B4436 ENOG4105D5Q Arginine ornithine antiporter BCG9842_B4438 ENOG4105CH6 catalase BCG9842_B4439 ENOG4107RKG DJ-1/PfpI family BCG9842_B4441 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF BCG9842_B4447 ENOG4105KPY Small multidrug resistance protein BCG9842_B4449 ENOG4105W1Y Transcriptional regulator BCG9842_B4450 ENOG4105UBK short-chain dehydrogenase reductase BCG9842_B4452 ENOG4108YXU transcriptional regulator AsnC family BCG9842_B4460 ENOG4106KNT transcriptional regulator BCG9842_B4462 ENOG4107RWR Sodium hydrogen exchanger BCG9842_B4463 ENOG4105CUB amino acid BCG9842_B4471 ENOG4107T5V SNARE associated Golgi BCG9842_B4479 ENOG4105WEF catalase BCG9842_B4485 ENOG4105C19 ABC transporter BCG9842_B4486 ENOG4107RBB ABC transporter, permease BCG9842_B4487 ENOG41069ER domain protein BCG9842_B4491 ENOG4105VZJ PTS System BCG9842_B4492 ENOG4105VCP PTS System BCG9842_B4493 ENOG4105EMD TRANSCRIPTIONal BCG9842_B4498 ENOG4108KGH TRANSCRIPTIONal BCG9842_B4500 ENOG41087NI Sulfite exporter TauE/SafE BCG9842_B4501 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BCG9842_B4503 ENOG4105VFE sira family BCG9842_B4504 ENOG4105VFE sira family BCG9842_B4505 ENOG4107TPS domain protein BCG9842_B4506 ENOG4105VFE sira family BCG9842_B4507 ENOG4105XTG Pfam:DUF156 BCG9842_B4509 ENOG4108TCS Glutamyl endopeptidase BCG9842_B4512 ENOG4105ED1 spovr family BCG9842_B4513 ENOG4107Y03 Nitroreductase BCG9842_B4517 ENOG4108B31 Spore germination protein BCG9842_B4521 ENOG4105K63 Thioredoxin BCG9842_B4524 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BCG9842_B4526 ENOG4105C7N Xanthine uracil vitamin C permease BCG9842_B4529 ENOG4108INS Transcriptional regulator BCG9842_B4540 ENOG4105DWF phosphomethylpyrimidine kinase BCG9842_B4541 ENOG4105D06 uba thif-type nad fad binding protein BCG9842_B4544 ENOG41080HI glycine oxidase BCG9842_B4545 ENOG4108VEU Thiamine monophosphate synthase BCG9842_B4547 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BCG9842_B4549 ENOG4105ETU transcriptional activator (TenA BCG9842_B4556 ENOG4105EKQ RNA-directed DNA polymerase BCG9842_B4559 ENOG41080XQ Signal transduction protein with cbs domains BCG9842_B4585 ENOG4105E2Z phosphate ABC transporter (Permease BCG9842_B4586 ENOG4105C8U phosphate abc transporter BCG9842_B4587 ENOG4105CVA phosphate BCG9842_B4588 ENOG4105CE1 Ferrous iron transport protein b BCG9842_B4589 ENOG4105CE1 Ferrous iron transport protein b BCG9842_B4590 ENOG4105CE1 Ferrous iron transport protein b BCG9842_B4592 ENOG4108NHD germination protein BCG9842_B4595 ENOG4105E1V na solute symporter BCG9842_B4596 ENOG4106CAD Protein of unknown function (DUF3311) BCG9842_B4600 ENOG4105E2S oxidase) subunit II BCG9842_B4601 ENOG4105BZ9 Cytochrome C oxidase, subunit I BCG9842_B4606 ENOG4105MA6 gCN5-related N-acetyltransferase BCG9842_B4609 ENOG4105C7N Xanthine uracil vitamin C permease BCG9842_B4610 ENOG4105C85 amino acid BCG9842_B4615 ENOG4105DUX Transporter BCG9842_B4618 ENOG4107D63 BCG9842_B4619 ENOG4105VZ8 Transcriptional regulator BCG9842_B4620 ENOG41069ER domain protein BCG9842_B4621 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BCG9842_B4622 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BCG9842_B4628 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) BCG9842_B4636 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BCG9842_B4637 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BCG9842_B4638 ENOG4105CNN ABC, transporter BCG9842_B4639 ENOG4105C2J ABC transporter BCG9842_B4641 ENOG4108RVA ribokinase BCG9842_B4642 ENOG4105ETE Transcriptional regulator (LacI family BCG9842_B4643 ENOG4105C0R drug resistance transporter emrb qaca subfamily BCG9842_B4644 ENOG41067TZ transcriptional regulator, MarR family BCG9842_B4646 ENOG4105CXY transporter BCG9842_B4648 ENOG41068KF Universal stress protein BCG9842_B4649 ENOG4105CHH sulfate transporter BCG9842_B4652 ENOG4105BZU Histidine kinase BCG9842_B4653 ENOG4105NAE bifunctional deaminase-reductase domain protein BCG9842_B4654 ENOG4105D29 Helix-turn-helix type 11 domain protein BCG9842_B4656 ENOG4105GFR rna polymerase sigma factor BCG9842_B4659 ENOG4108IQI permease BCG9842_B4660 ENOG4105DRP amino acid AbC transporter BCG9842_B4661 ENOG4105EAD ABC transporter BCG9842_B4662 ENOG4105CT1 (ABC) transporter BCG9842_B4663 ENOG4105CDA abc transporter atp-binding protein BCG9842_B4664 ENOG4105BZG amino acid carrier protein BCG9842_B4665 ENOG4105CRN Aminoglycoside phosphotransferase BCG9842_B4666 ENOG4105E1K spore germination protein BCG9842_B4669 ENOG4105CG3 alpha amylase, catalytic region BCG9842_B4670 ENOG4105C5Y PTS System BCG9842_B4671 ENOG4107414 GntR family transcriptional regulator BCG9842_B4672 ENOG4105D5Q Arginine ornithine antiporter BCG9842_B4673 ENOG4105BZU Histidine kinase BCG9842_B4675 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BCG9842_B4676 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BCG9842_B4677 ENOG4107T89 von Willebrand factor, type A BCG9842_B4679 ENOG4105EXW epimerase dehydratase BCG9842_B4682 ENOG4105E0A ABC, transporter BCG9842_B4683 ENOG4108IHU transport system permease protein BCG9842_B4684 ENOG4105DQ5 transport system permease protein BCG9842_B4685 ENOG4108MES Periplasmic binding protein BCG9842_B4686 ENOG4105DUX Transporter BCG9842_B4690 ENOG4105DAA L-lactate BCG9842_B4691 ENOG4108IJ0 Aspartate ammonia-lyase BCG9842_B4692 ENOG4105C37 (CBS) domain BCG9842_B4693 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BCG9842_B4694 ENOG4105D9N nucleoside BCG9842_B4695 ENOG4108KGH TRANSCRIPTIONal BCG9842_B4696 ENOG41073R8 VanW family BCG9842_B4703 ENOG4105DAP Nicotinate phosphoribosyltransferase BCG9842_B4704 ENOG4105C59 p-type ATPase BCG9842_B4706 ENOG4105CUB amino acid BCG9842_B4710 ENOG4108JB9 formate dehydrogenase BCG9842_B4711 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BCG9842_B4717 ENOG4105BZU Histidine kinase BCG9842_B4719 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BCG9842_B4720 ENOG4108UZ3 Transporter BCG9842_B4722 ENOG4105C6K Malic enzyme BCG9842_B4724 ENOG4108MRH transcriptional regulatory protein BCG9842_B4730 ENOG4105US7 Histidine kinase BCG9842_B4731 ENOG4108STX response regulator BCG9842_B4732 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BCG9842_B4733 ENOG4105BZ7 extracellular solute-binding protein family 1 BCG9842_B4734 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BCG9842_B4735 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BCG9842_B4736 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BCG9842_B4737 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BCG9842_B4742 ENOG4105D4T Citrate transporter BCG9842_B4743 ENOG4108V9W transcriptional regulatory protein BCG9842_B4744 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BCG9842_B4746 ENOG4105DZ6 Band 7 protein BCG9842_B4749 ENOG4105C94 Transporter BCG9842_B4752 ENOG4105CYN Serine protein kinase BCG9842_B4753 ENOG4105BZU Histidine kinase BCG9842_B4754 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BCG9842_B4756 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BCG9842_B4758 ENOG4108R9S DSBA oxidoreductase BCG9842_B4759 ENOG4108JQC penicillin-binding protein 1A BCG9842_B4784 ENOG4105G5W regulator Fur family BCG9842_B4785 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BCG9842_B4789 ENOG4108IUW ABC transporter BCG9842_B4791 ENOG4105CBC glutamate synthase BCG9842_B4792 ENOG4107NBY Membrane BCG9842_B4793 ENOG4105BZ1 (ABC) transporter BCG9842_B4798 ENOG4106BXE BCG9842_B4799 ENOG4105CEN a g-specific adenine glycosylase BCG9842_B4800 ENOG41067AE Membrane-bound metal-dependent hydrolase BCG9842_B4805 ENOG4105ECP epimerase BCG9842_B4806 ENOG4105CI2 imidazolone-5-propionate hydrolase BCG9842_B4810 ENOG4105F1A Pyruvate formate-lyase BCG9842_B4812 ENOG4105CKK Glycosyl transferase, family 2 BCG9842_B4813 ENOG4105C3I Nad-dependent epimerase dehydratase BCG9842_B4814 ENOG4107QQG Dehydrogenase BCG9842_B4815 ENOG4107R51 Glycosyl transferase, family 2 BCG9842_B4818 ENOG4108A04 Beta-lactamase BCG9842_B4820 ENOG4105CSV Glutaminase BCG9842_B4826 ENOG4108IQI permease BCG9842_B4828 ENOG4108JUB Transcriptional regulator BCG9842_B4830 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BCG9842_B4832 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BCG9842_B4839 ENOG4105UPD Calcium Proton BCG9842_B4840 ENOG410606W general stress protein BCG9842_B4843 ENOG4107ZTW SNARE associated Golgi BCG9842_B4845 ENOG4105C3F Signal peptidase i BCG9842_B4847 ENOG4108IPJ Membrane BCG9842_B4848 ENOG4105C59 p-type ATPase BCG9842_B4850 ENOG4107U9T Pfam:Ribonuclease_BN BCG9842_B4852 ENOG4105KJF protein tyrosine phosphatase BCG9842_B4853 ENOG41068PA UPF0435 protein BCG9842_B4856 ENOG4108TTB tellurium resistance protein BCG9842_B4857 ENOG4107TS3 membrane protein, TerC BCG9842_B4858 ENOG4106FN3 tellurium resistance protein BCG9842_B4859 ENOG4106FN3 tellurium resistance protein BCG9842_B4860 ENOG4108N0M stress protein BCG9842_B4866 ENOG4105DEU major facilitator superfamily BCG9842_B4869 ENOG41062JF Transcriptional regulator BCG9842_B4875 ENOG4105C5H ABC transporter BCG9842_B4877 ENOG4105D2X ABC transporter substrate-binding protein BCG9842_B4878 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BCG9842_B4883 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BCG9842_B4887 ENOG4105C9U ATP-dependent DNA helicase RecQ BCG9842_B4890 ENOG4105CI1 PTS System BCG9842_B4892 ENOG4105DNP FAD linked oxidase domain protein BCG9842_B4894 ENOG4108W63 CRP FNR family transcriptional regulator BCG9842_B4895 ENOG4105C5B carbamate kinase BCG9842_B4897 ENOG4105DBV ornithine carbamoyltransferase BCG9842_B4900 ENOG4105C8Q Methyl-accepting chemotaxis BCG9842_B4901 ENOG4105CDA abc transporter atp-binding protein BCG9842_B4902 ENOG4105EAB amino acid AbC transporter BCG9842_B4903 ENOG4105E5Q amino acid AbC transporter BCG9842_B4906 ENOG4105D2S major facilitator superfamily BCG9842_B4907 ENOG410756H nucleotidyltransferase BCG9842_B4912 ENOG4105BZU Histidine kinase BCG9842_B4915 ENOG4106UIA BCG9842_B4916 ENOG4106UIA BCG9842_B4920 ENOG4108V5C ABC transporter BCG9842_B4921 ENOG4105DQ5 transport system permease protein BCG9842_B4922 ENOG4105EHG Permease protein BCG9842_B4923 ENOG4107W7X Aldolase BCG9842_B4924 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BCG9842_B4925 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BCG9842_B4926 ENOG4105D3R alkyl hydroperoxide reductase BCG9842_B4931 ENOG4105DFD Na H antiporter BCG9842_B4932 ENOG4105DTQ mandelate racemase muconate lactonizing BCG9842_B4936 ENOG4108W15 Protein of unknown function (DUF1456) BCG9842_B4938 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BCG9842_B4940 ENOG4105D9N nucleoside BCG9842_B4946 ENOG4105KPY Small multidrug resistance protein BCG9842_B4947 ENOG4105C26 Dehydrogenase BCG9842_B4949 ENOG4108JPW Aminotransferase BCG9842_B4951 ENOG4105CBD Diacylglycerol kinase BCG9842_B4955 ENOG4107I77 yiaA/B two helix domain BCG9842_B4956 ENOG410834F Transcriptional regulator BCG9842_B4960 ENOG4105D01 (LipO)protein BCG9842_B4961 ENOG4108UMI ABC transporter, permease BCG9842_B4962 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BCG9842_B4964 ENOG4108W2Y isochorismatase BCG9842_B4969 ENOG4105C4R Atp-dependent dna helicase BCG9842_B4975 ENOG4105C12 Phosphoribosylglycinamide synthetase BCG9842_B4977 ENOG4108V3E phosphoribosylglycinamide formyltransferase BCG9842_B4982 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BCG9842_B4984 ENOG4105C83 adenylosuccinate lyase BCG9842_B4985 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BCG9842_B4986 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BCG9842_B4993 ENOG410631K Membrane BCG9842_B4998 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BCG9842_B5009 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BCG9842_B5014 ENOG4107ZXU DSBA oxidoreductase BCG9842_B5020 ENOG4105BZU Histidine kinase BCG9842_B5022 ENOG4105C7N Xanthine uracil vitamin C permease BCG9842_B5028 ENOG4108TYN CAAX amino terminal protease family protein BCG9842_B5031 ENOG4105C5H ABC transporter BCG9842_B5032 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BCG9842_B5033 ENOG410801F ribosomal-protein-alanine acetyltransferase BCG9842_B5034 ENOG41072GX Peptidase M22 Glycoprotease BCG9842_B5035 ENOG4105K8N protein family UPF0079, ATPase BCG9842_B5056 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BCG9842_B5058 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BCG9842_B5059 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BCG9842_B5064 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BCG9842_B5065 ENOG4105CPF Cell wall formation (By similarity) BCG9842_B5066 ENOG4108SC4 )-transporter BCG9842_B5067 ENOG4105CUB amino acid BCG9842_B5069 ENOG4105ERH Fumarylacetoacetate hydrolase BCG9842_B5070 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BCG9842_B5075 ENOG410667J hydrolase BCG9842_B5076 ENOG4108JQ7 (ABC) transporter BCG9842_B5077 ENOG4105C3U ABC transporter BCG9842_B5078 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BCG9842_B5080 ENOG4105DEF Extracellular solute-binding protein, family 5 BCG9842_B5082 ENOG4105C5H ABC transporter BCG9842_B5087 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BCG9842_B5091 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BCG9842_B5094 ENOG4105F6E Acyl-transferase BCG9842_B5098 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BCG9842_B5099 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BCG9842_B5100 ENOG4105E0C molybdate abc transporter BCG9842_B5106 ENOG4108J59 Extracellular solute-binding protein, family 5 BCG9842_B5107 ENOG4108J59 Extracellular solute-binding protein, family 5 BCG9842_B5111 ENOG4108JQ7 (ABC) transporter BCG9842_B5112 ENOG4105C3U ABC transporter BCG9842_B5113 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BCG9842_B5114 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BCG9842_B5119 ENOG4105C2C drug resistance transporter, Bcr CflA BCG9842_B5122 ENOG4105IQ5 FAD linked oxidase domain protein BCG9842_B5124 ENOG4105CB2 alcohol dehydrogenase BCG9842_B5126 ENOG4105D01 (LipO)protein BCG9842_B5127 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BCG9842_B5128 ENOG4108UMI ABC transporter, permease BCG9842_B5129 ENOG4108PSK reductase BCG9842_B5133 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BCG9842_B5136 ENOG4107U5W ybbr family BCG9842_B5137 ENOG4105C8B TIGR00159 family BCG9842_B5154 ENOG4108NMV polysaccharide deacetylase BCG9842_B5157 ENOG4105D1F ATP-binding protein BCG9842_B5163 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BCG9842_B5164 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BCG9842_B5165 ENOG4108JJB ABC transporter BCG9842_B5166 ENOG4108JJB ABC transporter BCG9842_B5171 ENOG41067V7 50S ribosomal protein L36 BCG9842_B5173 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BCG9842_B5175 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BCG9842_B5180 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BCG9842_B5201 ENOG4105XPM ribosomal protein BCG9842_B5202 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BCG9842_B5204 ENOG4107Y49 methyltransferase BCG9842_B5210 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BCG9842_B5212 ENOG4105QIV RNA polymerase BCG9842_B5213 ENOG4105M0M Tetracycline resistance protein BCG9842_B5214 ENOG4105C2N RNA methyltransferase TrmH family group 3 BCG9842_B5217 ENOG4105D7W serine acetyltransferase BCG9842_B5221 ENOG4105CTP PilT protein domain protein BCG9842_B5223 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BCG9842_B5226 ENOG4108Z0C Uvrb UvrC protein BCG9842_B5233 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BCG9842_B5235 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BCG9842_B5236 ENOG4105KRF dihydroneopterin aldolase BCG9842_B5237 ENOG4105EEI dihydropteroate synthase BCG9842_B5238 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BCG9842_B5239 ENOG4105DDQ anthranilate synthase BCG9842_B5240 ENOG4105CRQ synthase (Component I) BCG9842_B5241 ENOG4105C6T cysteine synthase BCG9842_B5244 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BCG9842_B5245 ENOG4108UGV hypoxanthine phosphoribosyltransferase BCG9842_B5246 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BCG9842_B5250 ENOG41060GV RNA binding s1 domain protein BCG9842_B5253 ENOG4105VYY sporulation protein yabp BCG9842_B5254 ENOG41082I2 s4 domain protein BCG9842_B5255 ENOG4108IY2 MazG family BCG9842_B5257 ENOG4108M14 stage v sporulation protein t BCG9842_B5258 ENOG4108JA2 transcriptioN-repair coupling factor BCG9842_B5260 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BCG9842_B5261 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BCG9842_B5264 ENOG4105KME endoribonuclease L-psp BCG9842_B5265 ENOG4105DFT pur operon repressor BCG9842_B5268 ENOG4105W42 Veg protein BCG9842_B5269 ENOG4105XFA sporulation peptidase YabG BCG9842_B5271 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BCG9842_B5272 ENOG4105F8V Hydrolase, tatD family BCG9842_B5273 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BCG9842_B5274 ENOG4105KRN Transcriptional regulator, abrb family BCG9842_B5275 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BCG9842_B5277 ENOG41060K3 Methyltransferase BCG9842_B5279 ENOG4105MA4 psp1 domain protein BCG9842_B5280 ENOG4105FA2 dna polymerase iii BCG9842_B5282 ENOG4105CXN decarboxylase BCG9842_B5290 ENOG41067KS pro-sigma K processing BCG9842_B5294 ENOG4105C6E dna polymerase iii BCG9842_B5296 ENOG4108Z6B deaminase BCG9842_B5297 ENOG4105GTG Isochorismatase BCG9842_B5299 ENOG4105ZMH deoxynucleoside kinase BCG9842_B5306 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BCG9842_B5314 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BCG9842_B5317 ENOG410848D S4 domain protein YaaA BCG9842_B5318 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BCG9842_B5322 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BCG9842_B5324 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BCG9842_B5328 ENOG4107QJE Chromosome Partitioning Protein BCG9842_B5329 ENOG4105FA0 parb-like partition protein BCG9842_B5330 ENOG4108ZDA Sporulation protein YyaC BCG9842_B5331 ENOG4105D8X mechanosensitive ion channel BCG9842_B5332 ENOG4105VDK protein, conserved in bacteria BCG9842_B5333 ENOG4105C3G gtp-binding protein BCG9842_B5335 ENOG4108UUM single-stranded DNA-binding protein BCG9842_B5337 ENOG4108XMW Membrane BCG9842_B5338 ENOG4105BZR domain protein BCG9842_B5340 ENOG4105CDU Replicative dna helicase BCG9842_B5341 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BCG9842_B5346 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BCG9842_B5347 ENOG4105BZU Histidine kinase BCG9842_B5350 ENOG4105Q2H domain protein BCG9842_B5351 ENOG4105C0H protease BCG9842_B5354 ENOG4105NI8 Cytosine-specific methyltransferase BCG9842_B5355 ENOG4105NI8 Cytosine-specific methyltransferase BCG9842_B5365 ENOG4105BZU Histidine kinase BCG9842_B5368 ENOG4105DPN Oligoendopeptidase f BCG9842_B5369 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) BCG9842_B5370 ENOG4105C1J atp-dependent rna helicase BCG9842_B5372 ENOG4108UT2 hemolysin iii BCG9842_B5373 ENOG4105CMR udp-glucose 4-epimerase BCG9842_B5376 ENOG4105IW1 AmiS UreI transporter BCG9842_B5378 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BCG9842_B5381 ENOG4107RGD Major Facilitator superfamily BCG9842_B5383 ENOG4108HRK Histidine kinase BCG9842_B5384 ENOG4108NEV two component transcriptional regulator, LytTR family BCG9842_B5387 ENOG4106F5Q Membrane BCG9842_B5388 ENOG4105E0X reductase BCG9842_B5390 ENOG41067SE Tetr family transcriptional regulator BCG9842_B5391 ENOG4105C5H ABC transporter BCG9842_B5392 ENOG4108IG5 Transcriptional regulator BCG9842_B5394 ENOG4105CKK Glycosyl transferase, family 2 BCG9842_B5395 ENOG4105EJV Membrane BCG9842_B5397 ENOG4105K64 Glycosyl transferase, family 2 BCG9842_B5400 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) BCG9842_B5401 ENOG4108S4H thioesterase Superfamily protein BCG9842_B5403 ENOG4106YBV Methyl-accepting chemotaxis BCG9842_B5404 ENOG4105EN6 Membrane BCG9842_B5406 ENOG4105CG5 Glycosyl transferase (Group 1 BCG9842_B5409 ENOG41079KZ Major Facilitator Superfamily BCG9842_B5410 ENOG4105DY9 regulatoR BCG9842_B5411 ENOG4105D22 carbon starvation protein BCG9842_B5412 ENOG4105VCD cytoplasmic protein BCG9842_B5414 ENOG4105BZU Histidine kinase BCG9842_B5415 ENOG4105DWF phosphomethylpyrimidine kinase BCG9842_B5416 ENOG4105BZU Histidine kinase BCG9842_B5417 ENOG4105WH1 Two component transcriptional regulator luxr family BCG9842_B5419 ENOG4108Y4K DNA-binding transcriptional activator BCG9842_B5424 ENOG4105D6E homoserine dehydrogenase BCG9842_B5427 ENOG41090WU lipolytic protein G-D-S-L family BCG9842_B5428 ENOG4105CJ1 ABC, transporter BCG9842_B5429 ENOG4108TU7 Inherit from COG: (ABC) transporter BCG9842_B5431 ENOG4105VCH membrane BCG9842_B5432 ENOG410667J hydrolase BCG9842_B5434 ENOG4107SVH Potassium channel protein BCG9842_B5438 ENOG4108VKI Cell wall hydrolase BCG9842_B5440 ENOG4107UEZ chlorite dismutase BCG9842_B5441 ENOG4108IJ2 phosphate acetyltransferase BCG9842_B5442 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) BCG9842_B5443 ENOG4108VCI transcription factor, rsfa family BCG9842_B5445 ENOG4105DQ5 transport system permease protein BCG9842_B5446 ENOG4105EHG Permease protein BCG9842_B5447 ENOG4105E0A ABC, transporter BCG9842_B5448 ENOG4108MES Periplasmic binding protein BCG9842_B5449 ENOG4105DCI Phosphohydrolase BCG9842_B5450 ENOG41069HH 4-oxalocrotonate tautomerase BCG9842_B5451 ENOG4108Z4T Peptidase M50 BCG9842_B5452 ENOG4108XFG YwhD family BCG9842_B5453 ENOG4105BZ4 penicillin-binding protein BCG9842_B5454 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BCG9842_B5456 ENOG4107SWG transcriptional regulator MERR family BCG9842_B5457 ENOG4105DXB Major Facilitator superfamily BCG9842_B5460 ENOG4105CYW agmatinase BCG9842_B5464 ENOG410684U Domain of unknown function (DUF1934) BCG9842_B5466 ENOG4105EMN RNA polymerase sigma factor BCG9842_B5470 ENOG4105IIU Aminopeptidase BCG9842_B5473 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BCG9842_B5474 ENOG4108M15 ABC transporter BCG9842_B5475 ENOG4105KCT ABC transporter BCG9842_B5476 ENOG4105BZU Histidine kinase BCG9842_B5478 ENOG4105D4Y metalloprotease BCG9842_B5481 ENOG4105BZU Histidine kinase BCG9842_B5484 ENOG4105DF6 Fe-S oxidoreductase BCG9842_B5486 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BCG9842_B5487 ENOG4105C1G acyl-Coa dehydrogenase BCG9842_B5488 ENOG4105C1G acyl-Coa dehydrogenase BCG9842_B5495 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BCG9842_B5496 ENOG4105CBT Fructose-1,6-bisphosphatase BCG9842_B5497 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BCG9842_B5500 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BCG9842_B5501 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BCG9842_B5502 ENOG4108ZXQ stage ii sporulation protein r BCG9842_B5504 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BCG9842_B5507 ENOG4107XC4 flavin reductase domain protein, FMN-binding BCG9842_B5508 ENOG4108VGI doxx family BCG9842_B5511 ENOG4108YZG isomerase BCG9842_B5512 ENOG4108UIC UPF0340 protein BCG9842_B5517 ENOG41062M3 atp synthase BCG9842_B5518 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BCG9842_B5528 ENOG4105BZU Histidine kinase BCG9842_B5529 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BCG9842_B5531 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BCG9842_B5532 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BCG9842_B5537 ENOG4105D65 subunit l BCG9842_B5538 ENOG4105C8S subunit m BCG9842_B5539 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BCG9842_B5540 ENOG4106778 Protein of unknown function (DUF1146) BCG9842_B5544 ENOG4105DY9 regulatoR BCG9842_B5547 ENOG4105FRN stage II sporulation protein BCG9842_B5549 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BCG9842_B5552 ENOG4107YJ4 chain length determinant protein BCG9842_B5553 ENOG4105HTX biosynthesis protein BCG9842_B5554 ENOG4107YJ4 chain length determinant protein BCG9842_B5555 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BCG9842_B5556 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BCG9842_B5557 ENOG4105D3Q Sugar transferase BCG9842_B5561 ENOG4105CJR Integral membrane protein (MviN BCG9842_B5562 ENOG4105CGN Glycosyl transferase (Group 1 BCG9842_B5563 ENOG4108IJ1 Dehydrogenase BCG9842_B5566 ENOG4108KGH TRANSCRIPTIONal BCG9842_B5568 ENOG4105CMR udp-glucose 4-epimerase BCG9842_B5569 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BCG9842_B5570 ENOG4105BZU Histidine kinase BCG9842_B5573 ENOG4105CXY transporter BCG9842_B5577 ENOG4105C19 ABC transporter BCG9842_B5578 ENOG4107RBB ABC transporter, permease BCG9842_B5580 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BCG9842_B5586 ENOG4105C0D helicase BCG9842_B5587 ENOG4105KBK Zinc finger, swim domain protein BCG9842_B5592 ENOG41069ER domain protein BCG9842_B5593 ENOG4105C94 Transporter BCG9842_B5597 ENOG4105EKQ RNA-directed DNA polymerase BCG9842_B5599 ENOG4107R8N Glycosyl transferase, family 2 BCG9842_B5606 ENOG4105E0M Sulfatase BCG9842_B5608 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) BCG9842_B5610 ENOG4105DAA L-lactate BCG9842_B5618 ENOG4107RSM transcriptional regulator BCG9842_B5619 ENOG4105ECB domain protein BCG9842_B5623 ENOG4105VZJ PTS System BCG9842_B5625 ENOG4105VCP PTS System BCG9842_B5626 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BCG9842_B5627 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BCG9842_B5629 ENOG4105CK1 PTS System BCG9842_B5630 ENOG4105VCP PTS System BCG9842_B5631 ENOG4105F8D glycoside hydrolase family 4 BCG9842_B5635 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BCG9842_B5637 ENOG4105ESV Glycosyl transferase, family 4 BCG9842_B5638 ENOG4105C6Y Udp-glucose 6-dehydrogenase BCG9842_B5639 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BCG9842_B5640 ENOG4108KGH TRANSCRIPTIONal BCG9842_B5641 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BCG9842_B5643 ENOG4105KVH Transcriptional regulator BCG9842_B5646 ENOG41081UC Inherit from COG: Competence protein BCG9842_B5647 ENOG4105VEQ Cold shock protein BCG9842_B5649 ENOG4105MS2 ribosomal subunit Interface protein BCG9842_B5654 ENOG4105CAK Cell division ATP-binding protein ftsE BCG9842_B5655 ENOG4105CRP Part of the ABC transporter FtsEX involved in BCG9842_B5656 ENOG4105CN1 protease BCG9842_B5658 ENOG4105BZ1 (ABC) transporter BCG9842_B5661 ENOG4105C5H ABC transporter BCG9842_B5662 ENOG4108WS4 fmn reductase BCG9842_B5664 ENOG4105DUM transcriptional regulator, lysR family BCG9842_B5665 ENOG4105HMI Membrane BCG9842_B5668 ENOG4107TXC Transcriptional regulator BCG9842_B5671 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BCG9842_B5672 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BCG9842_B5674 ENOG41086DT Membrane protein of unknown function BCG9842_B5678 ENOG4108S4C acetyltransferase BCG9842_B5680 ENOG4105C3M thioredoxin reductase BCG9842_B5682 ENOG4108Z4K mutator MutT protein BCG9842_B5684 ENOG4105CHW UPF0052 protein BCG9842_B5686 ENOG4105KRI phosphocarrier protein (HPr BCG9842_B5687 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BCG9842_B5688 ENOG4108QY0 Membrane BCG9842_B5691 ENOG4105CZ3 stage V sporulation protein ad BCG9842_B5692 ENOG41090VF Stage v sporulation protein ac BCG9842_B5696 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BCG9842_B5706 ENOG41067MG lrgb family BCG9842_B5707 ENOG4105XZU Preprotein translocase, subunit SecG BCG9842_B5709 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)