locus-tag class description F3L01_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) F3L01_00015 ENOG410848D S4 domain protein YaaA F3L01_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) F3L01_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) F3L01_00100 ENOG4105ZMH deoxynucleoside kinase F3L01_00110 ENOG4105GTG Isochorismatase F3L01_00120 ENOG4108Z6B deaminase F3L01_00130 ENOG4105C6E dna polymerase iii F3L01_00150 ENOG41067KS pro-sigma K processing F3L01_00185 ENOG4105CXN decarboxylase F3L01_00190 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) F3L01_00195 ENOG4105FA2 dna polymerase iii F3L01_00200 ENOG4105MA4 psp1 domain protein F3L01_00210 ENOG41060K3 Methyltransferase F3L01_00220 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) F3L01_00225 ENOG4105KRN Transcriptional regulator, abrb family F3L01_00230 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) F3L01_00235 ENOG4105F8V Hydrolase, tatD family F3L01_00240 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) F3L01_00250 ENOG4105XFA sporulation peptidase YabG F3L01_00255 ENOG4105W42 Veg protein F3L01_00270 ENOG4105DFT pur operon repressor F3L01_00275 ENOG4105KME endoribonuclease L-psp F3L01_00295 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) F3L01_00305 ENOG4108JA2 transcriptioN-repair coupling factor F3L01_00310 ENOG4108M14 stage v sporulation protein t F3L01_00320 ENOG4108IY2 MazG family F3L01_00325 ENOG41082I2 s4 domain protein F3L01_00330 ENOG4105VYY sporulation protein yabp F3L01_00345 ENOG41060GV RNA binding s1 domain protein F3L01_00365 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) F3L01_00370 ENOG4108UGV hypoxanthine phosphoribosyltransferase F3L01_00375 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) F3L01_00390 ENOG4105C6T cysteine synthase F3L01_00395 ENOG4105CRQ synthase (Component I) F3L01_00400 ENOG4105DDQ anthranilate synthase F3L01_00405 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 F3L01_00410 ENOG4105EEI dihydropteroate synthase F3L01_00415 ENOG4105KRF dihydroneopterin aldolase F3L01_00420 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase F3L01_00430 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) F3L01_00520 ENOG4108Z0C Uvrb UvrC protein F3L01_00535 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) F3L01_00540 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) F3L01_00545 ENOG4105CTP PilT protein domain protein F3L01_00550 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) F3L01_00565 ENOG4105D7W serine acetyltransferase F3L01_00580 ENOG4105C2N RNA methyltransferase TrmH family group 3 F3L01_00585 ENOG4105M0M Tetracycline resistance protein F3L01_00590 ENOG4105QIV RNA polymerase F3L01_00605 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) F3L01_00630 ENOG4107Y49 methyltransferase F3L01_00645 ENOG4105XPM ribosomal protein F3L01_00780 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) F3L01_00790 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) F3L01_00825 ENOG4108JJB ABC transporter F3L01_00830 ENOG4108JJB ABC transporter F3L01_00835 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) F3L01_00840 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) F3L01_00865 ENOG4105D1F ATP-binding protein F3L01_00880 ENOG4108NMV polysaccharide deacetylase F3L01_00960 ENOG4105C8B TIGR00159 family F3L01_00965 ENOG4107U5W ybbr family F3L01_00980 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) F3L01_01005 ENOG4108PSK reductase F3L01_01010 ENOG4108UMI ABC transporter, permease F3L01_01015 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) F3L01_01020 ENOG4105D01 (LipO)protein F3L01_01025 ENOG4105CB2 alcohol dehydrogenase F3L01_01035 ENOG4105IQ5 FAD linked oxidase domain protein F3L01_01050 ENOG4105C2C drug resistance transporter, Bcr CflA F3L01_01070 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component F3L01_01075 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component F3L01_01080 ENOG4105C3U ABC transporter F3L01_01085 ENOG4108JQ7 (ABC) transporter F3L01_01115 ENOG4108J59 Extracellular solute-binding protein, family 5 F3L01_01120 ENOG4108J59 Extracellular solute-binding protein, family 5 F3L01_01130 ENOG4105II7 pyrroline-5-carboxylate reductase F3L01_01140 ENOG4105E0C molybdate abc transporter F3L01_01145 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein F3L01_01150 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family F3L01_01165 ENOG4105EGI Transcriptional regulator F3L01_01185 ENOG4105F6E Acyl-transferase F3L01_01205 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) F3L01_01240 ENOG4105C5H ABC transporter F3L01_01255 ENOG4105DEF Extracellular solute-binding protein, family 5 F3L01_01265 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component F3L01_01270 ENOG4105C3U ABC transporter F3L01_01275 ENOG4108JQ7 (ABC) transporter F3L01_01280 ENOG410667J hydrolase F3L01_01305 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase F3L01_01310 ENOG4105ERH Fumarylacetoacetate hydrolase F3L01_01320 ENOG4105CUB amino acid F3L01_01325 ENOG4108SC4 )-transporter F3L01_01330 ENOG4105CPF Cell wall formation (By similarity) F3L01_01335 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) F3L01_01360 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein F3L01_01365 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) F3L01_01375 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) F3L01_01480 ENOG4105K8N protein family UPF0079, ATPase F3L01_01485 ENOG41072GX Peptidase M22 Glycoprotease F3L01_01490 ENOG410801F ribosomal-protein-alanine acetyltransferase F3L01_01495 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) F3L01_01500 ENOG4105C5H ABC transporter F3L01_01515 ENOG4108TYN CAAX amino terminal protease family protein F3L01_01535 ENOG4105C7N Xanthine uracil vitamin C permease F3L01_01545 ENOG4105BZU Histidine kinase F3L01_01575 ENOG4107ZXU DSBA oxidoreductase F3L01_01625 ENOG4105DPZ Two component transcriptional regulator (Winged helix family F3L01_01655 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) F3L01_01665 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) F3L01_01675 ENOG4108SHN Glycosyl transferase, family 2 F3L01_01695 ENOG4105SX7 Transporter F3L01_01725 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) F3L01_01730 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit F3L01_01735 ENOG4105C83 adenylosuccinate lyase F3L01_01745 ENOG4105VR9 phosphoribosylformylglycinamidine synthase F3L01_01755 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii F3L01_01770 ENOG4108V3E phosphoribosylglycinamide formyltransferase F3L01_01775 ENOG4105DC1 bifunctional purine biosynthesis protein purh F3L01_01780 ENOG4105C12 Phosphoribosylglycinamide synthetase F3L01_01810 ENOG4105C4R Atp-dependent dna helicase F3L01_01815 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) F3L01_01835 ENOG4108W2Y isochorismatase F3L01_01840 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) F3L01_01845 ENOG4108UMI ABC transporter, permease F3L01_01850 ENOG4105D01 (LipO)protein F3L01_01870 ENOG410834F Transcriptional regulator F3L01_01875 ENOG4107I77 yiaA/B two helix domain F3L01_01885 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) F3L01_01895 ENOG4105CBD Diacylglycerol kinase F3L01_01905 ENOG4108JPW Aminotransferase F3L01_01915 ENOG4105C26 Dehydrogenase F3L01_01920 ENOG4105KPY Small multidrug resistance protein F3L01_01945 ENOG4105D9N nucleoside F3L01_01950 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) F3L01_01960 ENOG4108W15 Protein of unknown function (DUF1456) F3L01_01980 ENOG4105DTQ mandelate racemase muconate lactonizing F3L01_01990 ENOG4105DFD Na H antiporter F3L01_02010 ENOG4105D3R alkyl hydroperoxide reductase F3L01_02030 ENOG4105EHG Permease protein F3L01_02035 ENOG4105DQ5 transport system permease protein F3L01_02040 ENOG4108V5C ABC transporter F3L01_02070 ENOG4106UIA F3L01_02075 ENOG4106UIA F3L01_02090 ENOG4105BZU Histidine kinase F3L01_02110 ENOG410756H nucleotidyltransferase F3L01_02115 ENOG4105D2S major facilitator superfamily F3L01_02130 ENOG4105E5Q amino acid AbC transporter F3L01_02135 ENOG4105EAB amino acid AbC transporter F3L01_02140 ENOG4105CDA abc transporter atp-binding protein F3L01_02145 ENOG4105C8Q Methyl-accepting chemotaxis F3L01_02160 ENOG4105DBV ornithine carbamoyltransferase F3L01_02170 ENOG4105C5B carbamate kinase F3L01_02175 ENOG4108W63 CRP FNR family transcriptional regulator F3L01_02185 ENOG4105DNP FAD linked oxidase domain protein F3L01_02195 ENOG4105CI1 PTS System F3L01_02210 ENOG4105C9U ATP-dependent DNA helicase RecQ F3L01_02215 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase F3L01_02220 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) F3L01_02225 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter F3L01_02245 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component F3L01_02250 ENOG4105D2X ABC transporter substrate-binding protein F3L01_02295 ENOG41062JF Transcriptional regulator F3L01_02310 ENOG4105DEU major facilitator superfamily F3L01_02325 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) F3L01_02340 ENOG4108N0M stress protein F3L01_02345 ENOG4106FN3 tellurium resistance protein F3L01_02350 ENOG4106FN3 tellurium resistance protein F3L01_02355 ENOG4107TS3 membrane protein, TerC F3L01_02360 ENOG4108TTB tellurium resistance protein F3L01_02380 ENOG4105KJF protein tyrosine phosphatase F3L01_02390 ENOG4107U9T Pfam:Ribonuclease_BN F3L01_02395 ENOG4105C59 p-type ATPase F3L01_02400 ENOG4108IPJ Membrane F3L01_02420 ENOG4107ZTW SNARE associated Golgi F3L01_02435 ENOG410606W general stress protein F3L01_02440 ENOG4105UPD Calcium Proton F3L01_02475 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) F3L01_02480 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) F3L01_02490 ENOG4108JUB Transcriptional regulator F3L01_02500 ENOG4108IQI permease F3L01_02540 ENOG4108A04 Beta-lactamase F3L01_02555 ENOG4105CKK Glycosyl transferase, family 2 F3L01_02560 ENOG4107QQG Dehydrogenase F3L01_02565 ENOG4105C3I Nad-dependent epimerase dehydratase F3L01_02585 ENOG4105F1A Pyruvate formate-lyase F3L01_02590 ENOG4108QBV Monogalactosyldiacylglycerol synthase F3L01_02605 ENOG4105CI2 imidazolone-5-propionate hydrolase F3L01_02610 ENOG4105ECP epimerase F3L01_02640 ENOG41067AE Membrane-bound metal-dependent hydrolase F3L01_02645 ENOG4105CEN a g-specific adenine glycosylase F3L01_02650 ENOG4106BXE F3L01_02670 ENOG4105BZ1 (ABC) transporter F3L01_02675 ENOG4107NBY Membrane F3L01_02680 ENOG4105CBC glutamate synthase F3L01_02690 ENOG4108IUW ABC transporter F3L01_02710 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen F3L01_02715 ENOG4105G5W regulator Fur family F3L01_02835 ENOG4108JQC penicillin-binding protein 1A F3L01_02840 ENOG4108R9S DSBA oxidoreductase F3L01_02850 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) F3L01_02860 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) F3L01_02865 ENOG4105BZU Histidine kinase F3L01_02870 ENOG4105CYN Serine protein kinase F3L01_02875 ENOG4106AKX UPF0229 protein F3L01_02890 ENOG4105C94 Transporter F3L01_02905 ENOG4105DZ6 Band 7 protein F3L01_02915 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism F3L01_02920 ENOG4108V9W transcriptional regulatory protein F3L01_02925 ENOG4105D4T Citrate transporter F3L01_02950 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator F3L01_02955 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) F3L01_02960 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component F3L01_02965 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component F3L01_02970 ENOG4105BZ7 extracellular solute-binding protein family 1 F3L01_02975 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) F3L01_02980 ENOG4108STX response regulator F3L01_02985 ENOG41062D9 Histidine kinase F3L01_03010 ENOG4108MRH transcriptional regulatory protein F3L01_03020 ENOG4105C6K Malic enzyme F3L01_03030 ENOG4108UZ3 Transporter F3L01_03035 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family F3L01_03045 ENOG4105BZU Histidine kinase F3L01_03050 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L01_03060 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) F3L01_03065 ENOG4108JB9 formate dehydrogenase F3L01_03100 ENOG4105C59 p-type ATPase F3L01_03140 ENOG41073R8 VanW family F3L01_03145 ENOG4108KGH TRANSCRIPTIONal F3L01_03150 ENOG4105D9N nucleoside F3L01_03155 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase F3L01_03160 ENOG4105C37 (CBS) domain F3L01_03165 ENOG4108IJ0 Aspartate ammonia-lyase F3L01_03170 ENOG4105DAA L-lactate F3L01_03185 ENOG4105DUX Transporter F3L01_03190 ENOG4108MES Periplasmic binding protein F3L01_03195 ENOG4105DQ5 transport system permease protein F3L01_03200 ENOG4108IHU transport system permease protein F3L01_03205 ENOG4105E0A ABC, transporter F3L01_03215 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) F3L01_03220 ENOG4105EXW epimerase dehydratase F3L01_03230 ENOG4107T89 von Willebrand factor, type A F3L01_03235 ENOG4105GMT ATPase associated with various cellular activities aaa_5 F3L01_03240 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) F3L01_03250 ENOG4105BZU Histidine kinase F3L01_03255 ENOG4105D5Q Arginine ornithine antiporter F3L01_03260 ENOG4107414 GntR family transcriptional regulator F3L01_03265 ENOG4105C5Y PTS System F3L01_03270 ENOG4105CG3 alpha amylase, catalytic region F3L01_03285 ENOG4105E1K spore germination protein F3L01_03290 ENOG4108XG2 Histidine kinase F3L01_03295 ENOG4105WH1 Two component transcriptional regulator luxr family F3L01_03300 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin F3L01_03310 ENOG4105CRN Aminoglycoside phosphotransferase F3L01_03315 ENOG4105BZG amino acid carrier protein F3L01_03325 ENOG4105CDA abc transporter atp-binding protein F3L01_03330 ENOG4105CT1 (ABC) transporter F3L01_03335 ENOG4105EAD ABC transporter F3L01_03340 ENOG4105DRP amino acid AbC transporter F3L01_03345 ENOG4108IQI permease F3L01_03370 ENOG4105D29 Helix-turn-helix type 11 domain protein F3L01_03375 ENOG4105NAE bifunctional deaminase-reductase domain protein F3L01_03380 ENOG4105BZU Histidine kinase F3L01_03385 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L01_03395 ENOG4105CHH sulfate transporter F3L01_03400 ENOG41068KF Universal stress protein F3L01_03410 ENOG4105CXY transporter F3L01_03415 ENOG41067TZ transcriptional regulator, MarR family F3L01_03420 ENOG4105C0R drug resistance transporter emrb qaca subfamily F3L01_03425 ENOG4105ETE Transcriptional regulator (LacI family F3L01_03430 ENOG4108RVA ribokinase F3L01_03440 ENOG4105C2J ABC transporter F3L01_03445 ENOG4105CNN ABC, transporter F3L01_03450 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator F3L01_03455 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) F3L01_03485 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) F3L01_03515 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) F3L01_03520 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer F3L01_03525 ENOG41069ER domain protein F3L01_03530 ENOG4105VZ8 Transcriptional regulator F3L01_03535 ENOG4107D63 F3L01_03550 ENOG4105DUX Transporter F3L01_03570 ENOG4105C85 amino acid F3L01_03575 ENOG4105C7N Xanthine uracil vitamin C permease F3L01_03590 ENOG4105MA6 gCN5-related N-acetyltransferase F3L01_03620 ENOG4105E2S oxidase) subunit II F3L01_03640 ENOG4106CAD Protein of unknown function (DUF3311) F3L01_03645 ENOG4105E1V na solute symporter F3L01_03665 ENOG4105CE1 Ferrous iron transport protein b F3L01_03670 ENOG4105CE1 Ferrous iron transport protein b F3L01_03675 ENOG4105CE1 Ferrous iron transport protein b F3L01_03680 ENOG4105CVA phosphate F3L01_03685 ENOG4105C8U phosphate abc transporter F3L01_03690 ENOG4105E2Z phosphate ABC transporter (Permease F3L01_03815 ENOG41080XQ Signal transduction protein with cbs domains F3L01_03835 ENOG4105ETU transcriptional activator (TenA F3L01_03845 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component F3L01_03855 ENOG4108VEU Thiamine monophosphate synthase F3L01_03860 ENOG41080HI glycine oxidase F3L01_03875 ENOG4105D06 uba thif-type nad fad binding protein F3L01_03880 ENOG4105DWF phosphomethylpyrimidine kinase F3L01_03915 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) F3L01_03930 ENOG4108INS Transcriptional regulator F3L01_03940 ENOG4105C7N Xanthine uracil vitamin C permease F3L01_03950 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein F3L01_03970 ENOG4105C5Y PTS System F3L01_03985 ENOG4105K63 Thioredoxin F3L01_04005 ENOG4108B31 Spore germination protein F3L01_04025 ENOG4107Y03 Nitroreductase F3L01_04060 ENOG4105ED1 spovr family F3L01_04070 ENOG4105J4Q Transcriptional regulator F3L01_04085 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase F3L01_04090 ENOG4105XTG Pfam:DUF156 F3L01_04095 ENOG4105VFE sira family F3L01_04100 ENOG4107TPS domain protein F3L01_04105 ENOG4105VFE sira family F3L01_04110 ENOG4105VFE sira family F3L01_04115 ENOG41085GJ domain protein F3L01_04120 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase F3L01_04125 ENOG41087NI Sulfite exporter TauE/SafE F3L01_04135 ENOG4108KGH TRANSCRIPTIONal F3L01_04165 ENOG4105EMD TRANSCRIPTIONal F3L01_04170 ENOG4105VCP PTS System F3L01_04175 ENOG4105VZJ PTS System F3L01_04195 ENOG41069ER domain protein F3L01_04200 ENOG4107RBB ABC transporter, permease F3L01_04205 ENOG4105C19 ABC transporter F3L01_04235 ENOG4105WEF catalase F3L01_04270 ENOG4107T5V SNARE associated Golgi F3L01_04300 ENOG4105CUB amino acid F3L01_04305 ENOG4107RWR Sodium hydrogen exchanger F3L01_04315 ENOG4106KNT transcriptional regulator F3L01_04320 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate F3L01_04355 ENOG4108YXU transcriptional regulator AsnC family F3L01_04360 ENOG4105CH7 arginosuccinase F3L01_04365 ENOG4105CYX Short-chain dehydrogenase reductase Sdr F3L01_04405 ENOG4105NF4 modulator of drug activity F3L01_04410 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) F3L01_04415 ENOG4105E5W Transporter F3L01_04425 ENOG4107RKG DJ-1/PfpI family F3L01_04430 ENOG4105CH6 catalase F3L01_04445 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) F3L01_04455 ENOG4105C26 Dehydrogenase F3L01_04470 ENOG4105BZ1 (ABC) transporter F3L01_04475 ENOG4105BZ1 (ABC) transporter F3L01_04490 ENOG4105DRP amino acid AbC transporter F3L01_04495 ENOG4105CDA abc transporter atp-binding protein F3L01_04510 ENOG410839P F3L01_04530 ENOG4105BZU Histidine kinase F3L01_04535 ENOG4105WH1 Two component transcriptional regulator luxr family F3L01_04545 ENOG4107FQX Alpha-acetolactate decarboxylase F3L01_04555 ENOG4108VX5 3-methyladenine DNA glycosylase F3L01_04570 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase F3L01_04575 ENOG4105D4P Coproporphyrinogen iii oxidase F3L01_04580 ENOG4105CEY Amp-dependent synthetase and ligase F3L01_04595 ENOG4105CHH sulfate transporter F3L01_04620 ENOG4105CGU Enoyl-CoA hydratase F3L01_04640 ENOG4105DER m42 family F3L01_04660 ENOG4105CTU Proline racemase F3L01_04665 ENOG4105CIF Ornithine Cyclodeaminase F3L01_04680 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component F3L01_04690 ENOG4108JQ7 (ABC) transporter F3L01_04755 ENOG4108IBT Inherit from COG: transposase F3L01_04815 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) F3L01_04895 ENOG4105CSH Transporter F3L01_04905 ENOG4108MRH transcriptional regulatory protein F3L01_04965 ENOG4105CDU Replicative dna helicase F3L01_04990 ENOG4105C0R drug resistance transporter emrb qaca subfamily F3L01_05005 ENOG4105D9U N-acetyltransferase F3L01_05025 ENOG4105F6J Alpha beta hydrolase fold F3L01_05055 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase F3L01_05070 ENOG4105CMT Dihydroxyacetone kinase F3L01_05085 ENOG4105CMT Dihydroxyacetone kinase F3L01_05150 ENOG4108WC5 Alpha Beta Hydrolase Fold protein F3L01_05190 ENOG4105WN5 stage II sporulation protein F3L01_05200 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F3L01_05210 ENOG4108MJI response regulator F3L01_05215 ENOG4105BZU Histidine kinase F3L01_05220 ENOG4105BZU Histidine kinase F3L01_05260 ENOG4107QHE Choloylglycine hydrolase F3L01_05280 ENOG4107VRP DNA repair exonuclease F3L01_05285 ENOG4106D4I domain protein F3L01_05315 ENOG4108MUZ hydrolase F3L01_05340 ENOG4105F0F Oxalate decarboxylase F3L01_05345 ENOG41067QW Transcriptional regulator F3L01_05350 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator F3L01_05365 ENOG4105C6V Glycerol-3-phosphate dehydrogenase F3L01_05380 ENOG4105DU6 RNA polymerase F3L01_05405 ENOG4105EEM helicase F3L01_05415 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) F3L01_05445 ENOG4105K59 histidine triad (HIT) protein F3L01_05475 ENOG410905X membrane-flanked domain protein F3L01_05480 ENOG4105CKV Membrane F3L01_05515 ENOG410905X membrane-flanked domain protein F3L01_05520 ENOG4105CKV Membrane F3L01_05525 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation F3L01_05530 ENOG4105BZ4 penicillin-binding protein F3L01_05540 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) F3L01_05545 ENOG4105C1Q protoporphyrinogen oxidase F3L01_05570 ENOG4105NA0 Transcriptional regulator F3L01_05585 ENOG4105ECB domain protein F3L01_05605 ENOG4108MK9 spermidine N(1)-acetyltransferase F3L01_05615 ENOG4106AXD F3L01_05620 ENOG4108RQ5 Beta-lactamase domain-containing protein F3L01_05625 ENOG4105DF9 Lipoate-protein, ligase F3L01_05635 ENOG4105CEY Amp-dependent synthetase and ligase F3L01_05645 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein F3L01_05650 ENOG4108I5D sulfate abc transporter F3L01_05655 ENOG4105ECW sulfate abc transporter F3L01_05660 ENOG4108IJ6 ABC transporter F3L01_05735 ENOG4107RN3 metallophosphoesterase F3L01_05740 ENOG4107TVP HD domain protein F3L01_05750 ENOG4108AEY RNA polymerase sigma factor F3L01_05755 ENOG41086D8 Transcriptional regulator F3L01_05770 ENOG4105DPZ Two component transcriptional regulator (Winged helix family F3L01_05790 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 F3L01_05795 ENOG4105C8Q Methyl-accepting chemotaxis F3L01_05800 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) F3L01_05810 ENOG4107QP3 malate synthase g F3L01_05865 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation F3L01_05870 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) F3L01_05910 ENOG4105ERH Fumarylacetoacetate hydrolase F3L01_05920 ENOG4105C8Y Acetylornithine aminotransferase F3L01_05940 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) F3L01_05945 ENOG4105CH6 catalase F3L01_05950 ENOG4105BZU Histidine kinase F3L01_05975 ENOG4105QNR S1 RNA binding domain protein F3L01_05980 ENOG4105CNA YD repeat protein F3L01_05990 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) F3L01_06000 ENOG4107AYK membrAne F3L01_06005 ENOG41073B9 F3L01_06015 ENOG4108KP7 hydrolase F3L01_06025 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit F3L01_06050 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) F3L01_06055 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) F3L01_06070 ENOG4105C31 Tryptophanyl-tRNA synthetase F3L01_06090 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component F3L01_06095 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component F3L01_06105 ENOG4108JQ7 (ABC) transporter F3L01_06110 ENOG4105UQX Mate efflux family protein F3L01_06130 ENOG4108ZCF integral membrane protein F3L01_06140 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) F3L01_06150 ENOG4105DPN Oligoendopeptidase f F3L01_06160 ENOG4108Z18 K06886 hemoglobin F3L01_06165 ENOG4105MIX Adenylate cyclase F3L01_06180 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) F3L01_06185 ENOG4105EMS pseudouridine synthase F3L01_06205 ENOG4105K64 Glycosyl transferase, family 2 F3L01_06225 ENOG4107TVC Glycosyl transferase, family 2 F3L01_06245 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) F3L01_06250 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase F3L01_06260 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase F3L01_06335 ENOG4105CK7 Sodium proline symporter F3L01_06345 ENOG4105DDQ anthranilate synthase F3L01_06355 ENOG4105DK0 Indole-3-glycerol phosphate synthase F3L01_06360 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase F3L01_06365 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) F3L01_06370 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) F3L01_06435 ENOG4105C7S Dehydrogenase F3L01_06470 ENOG4108IUX (ABC) transporter F3L01_06475 ENOG4105RHA ABC transporter, permease F3L01_06505 ENOG4105DZ1 carboxypeptidase F3L01_06510 ENOG4105VFR signal peptidase F3L01_06545 ENOG4105C26 Dehydrogenase F3L01_06550 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) F3L01_06555 ENOG4105F38 ABC transporter, permease F3L01_06560 ENOG4105D38 putrescine abc transporter F3L01_06565 ENOG4108HM4 ABC transporter F3L01_06575 ENOG4105EYF MMPL domain protein F3L01_06585 ENOG4108YBP pseudouridine synthase F3L01_06595 ENOG4105K4I Scp-like extracellular F3L01_06600 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) F3L01_06605 ENOG4105CQB FAD linked oxidase domain protein F3L01_06620 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L01_06625 ENOG4105BZU Histidine kinase F3L01_06630 ENOG4105JXH GntR family transcriptional regulator F3L01_06650 ENOG4106A3R peptidase F3L01_06660 ENOG4108QTI )-transporter F3L01_06665 ENOG4107TS3 membrane protein, TerC F3L01_06670 ENOG4105CZN Potassium uptake protein F3L01_06675 ENOG410681C small acid-soluble spore protein F3L01_06680 ENOG4108Z7G MaoC domain protein dehydratase F3L01_06700 ENOG4105CHR reductase F3L01_06730 ENOG4105C4Y ABC transporter F3L01_06735 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) F3L01_06740 ENOG4107RCV ABC transporter, permease F3L01_06760 ENOG4105E98 transcriptional regulator DeoR family F3L01_06770 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) F3L01_06780 ENOG4105PXI polysaccharide deacetylase F3L01_06790 ENOG4105BZU Histidine kinase F3L01_06795 ENOG41090MY MarR family Transcriptional regulator F3L01_06805 ENOG4106DF1 F3L01_06810 ENOG4105BZU Histidine kinase F3L01_06815 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) F3L01_06820 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase F3L01_06825 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) F3L01_06870 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) F3L01_06875 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) F3L01_06880 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) F3L01_06885 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family F3L01_06890 ENOG4105CZV ABC transporter F3L01_06900 ENOG4105CJ1 ABC, transporter F3L01_06940 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A F3L01_06945 ENOG4105EA8 2-Nitropropane dioxygenase F3L01_06950 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD F3L01_06960 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein F3L01_06980 ENOG4105NQC Flavodoxin F3L01_07010 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) F3L01_07040 ENOG4105CZN Potassium uptake protein F3L01_07045 ENOG41063Y9 F3L01_07050 ENOG4105KBJ sporulation protein ytfj F3L01_07070 ENOG4105CM2 brancheD-chain amino acid aminotransferase F3L01_07075 ENOG4105C7K acetolactate synthase F3L01_07080 ENOG4108ZP8 Acetolactate synthase small subunit F3L01_07085 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase F3L01_07100 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) F3L01_07115 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) F3L01_07120 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) F3L01_07125 ENOG4105ECC imidazole-glycerol-phosphate dehydratase F3L01_07130 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) F3L01_07135 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase F3L01_07140 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) F3L01_07150 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase F3L01_07170 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase F3L01_07175 ENOG4105E0M Sulfatase F3L01_07185 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) F3L01_07205 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) F3L01_07210 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) F3L01_07220 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) F3L01_07225 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein F3L01_07230 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein F3L01_07235 ENOG4105C8J )-transporter F3L01_07255 ENOG4105DFD Na H antiporter F3L01_07275 ENOG4105ENE Histidine kinase F3L01_07280 ENOG4105WH1 Two component transcriptional regulator luxr family F3L01_07300 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) F3L01_07325 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) F3L01_07345 ENOG4105CJ3 phosphate transporter F3L01_07350 ENOG4107GRR phosphate transport regulator F3L01_07355 ENOG4105BZ4 penicillin-binding protein F3L01_07370 ENOG4105BZU Histidine kinase F3L01_07375 ENOG4105I3N Conserved Protein F3L01_07390 ENOG4105BZU Histidine kinase F3L01_07395 ENOG4105D3A purine nucleoside phosphorylase DeoD-type F3L01_07420 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) F3L01_07425 ENOG4105DZ1 carboxypeptidase F3L01_07430 ENOG4108JIC nucleoside recognition domain protein F3L01_07440 ENOG4105FE9 pseudouridine synthase F3L01_07445 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen F3L01_07450 ENOG4107TWT Cytochrome c biogenesis protein F3L01_07455 ENOG4105CRE cytochrome C F3L01_07460 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L01_07465 ENOG4105BZU Histidine kinase F3L01_07470 ENOG4108WBT adenosyltransferase F3L01_07485 ENOG4108SAX Membrane F3L01_07500 ENOG4105C9U ATP-dependent DNA helicase RecQ F3L01_07505 ENOG4105I7S Abortive infection protein F3L01_07515 ENOG4107RGJ metallophosphoesterase F3L01_07520 ENOG4108XDN Transcriptional regulator F3L01_07525 ENOG4108S6Z Negative regulator of genetic competence F3L01_07550 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase F3L01_07555 ENOG4107RB3 L-asparaginase F3L01_07570 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) F3L01_07585 ENOG4105S2F F3L01_07590 ENOG41065D1 F3L01_07620 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) F3L01_07635 ENOG4105XXQ heptaprenyl diphosphate synthase component I F3L01_07645 ENOG4105EAH synthase F3L01_07650 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) F3L01_07655 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase F3L01_07660 ENOG4105D49 3-dehydroquinate synthase F3L01_07670 ENOG41068YB TPR repeat-containing protein F3L01_07685 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) F3L01_07690 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) F3L01_07725 ENOG4108JYZ YitT family F3L01_07735 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase F3L01_07740 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) F3L01_07750 ENOG4105FJR Lmbe family F3L01_07755 ENOG4105CPK Glycosyl transferase (Group 1 F3L01_07775 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) F3L01_07790 ENOG4105DVT helicase F3L01_07795 ENOG4105YAC F3L01_07815 ENOG4105CSM endonuclease III F3L01_07825 ENOG4105BZ4 penicillin-binding protein F3L01_07865 ENOG4106F55 Protein of unknown function (DUF1273) F3L01_07880 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) F3L01_07920 ENOG4105DVT helicase F3L01_07925 ENOG4105CTD carboxy-peptidase F3L01_07935 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) F3L01_07950 ENOG4105C2W permease F3L01_07955 ENOG4105DHF Membrane F3L01_07960 ENOG410890F Dynamin family F3L01_07970 ENOG4108W0I acetyltransferase F3L01_07980 ENOG4105KHC sulfurtransferase F3L01_08035 ENOG4105HTX biosynthesis protein F3L01_08065 ENOG4105CPK Glycosyl transferase (Group 1 F3L01_08080 ENOG4108SZE gCN5-related N-acetyltransferase F3L01_08100 ENOG41081VK Ribonuclease F3L01_08165 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) F3L01_08175 ENOG4107RWR Sodium hydrogen exchanger F3L01_08180 ENOG4105CN5 Metallo-Beta-Lactamase F3L01_08185 ENOG4108Z5V transcriptional regulator, merr family F3L01_08195 ENOG4105H67 Protein of unknown function (DUF421) F3L01_08200 ENOG41080C8 DUF218 domain F3L01_08235 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) F3L01_08245 ENOG4107R0U MotA TolQ exbB proton channel F3L01_08250 ENOG4105ER2 Ompa motb domain protein F3L01_08255 ENOG4107YTP response regulator receiver protein F3L01_08260 ENOG4105CBS Chea signal transduction histidine kinase F3L01_08265 ENOG4105DD5 Flagellar motor switch protein F3L01_08280 ENOG4105BZU Histidine kinase F3L01_08300 ENOG4105E1Q flagellar hook-associated protein F3L01_08305 ENOG4105DTJ flagellar hook-associated protein F3L01_08310 ENOG4107TPX flagellar hook-associated F3L01_08325 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) F3L01_08330 ENOG4108ZC9 flagellar basal-body rod protein flgc F3L01_08345 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) F3L01_08375 ENOG4105BZE flagellar hook protein, FlgE F3L01_08390 ENOG4107R88 Chemotaxis protein (CheV) F3L01_08400 ENOG4105I03 Flagellin F3L01_08405 ENOG4105I03 Flagellin F3L01_08410 ENOG4105I03 Flagellin F3L01_08415 ENOG4105I03 Flagellin F3L01_08420 ENOG4105I03 Flagellin F3L01_08425 ENOG4105E4C Lytic transglycosylase catalytic F3L01_08435 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) F3L01_08440 ENOG4105DD5 Flagellar motor switch protein F3L01_08450 ENOG4105CN7 Flagellar biosynthetic protein FliP F3L01_08455 ENOG4105VS8 Flagellar biosynthetic protein fliq F3L01_08465 ENOG4105D00 flagellar biosynthetic protein flhB F3L01_08470 ENOG4105D7B Flagellar biosynthesis protein flha F3L01_08475 ENOG4105FZW flagellar biosynthesis regulator FlhF F3L01_08480 ENOG4105KTQ flagellar basal-body rod protein F3L01_08485 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) F3L01_08520 ENOG4105KAC Antibiotic biosynthesis monooxygenase F3L01_08595 ENOG4105CVJ phosphoglycerate mutase F3L01_08605 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) F3L01_08625 ENOG4105CAQ asparagine synthetase F3L01_08645 ENOG4105PGM cation diffusion facilitator family transporter F3L01_08655 ENOG4105DRR Transcriptional regulator, GntR family F3L01_08670 ENOG4105CKI cobalamin synthesis protein F3L01_08675 ENOG4108PJD permease F3L01_08690 ENOG4105DFD Na H antiporter F3L01_08695 ENOG4105VUF Transcriptional regulator F3L01_08705 ENOG4105C9Q fumarate hydratase class II F3L01_08720 ENOG4107QJQ Mate efflux family protein F3L01_08725 ENOG4105EC3 peptidase S51, dipeptidase E F3L01_08750 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen F3L01_08760 ENOG4107JM4 Tetratricopeptide repeat F3L01_08775 ENOG4105BZC d-serine deaminase F3L01_08780 ENOG4106BRA Membrane F3L01_08820 ENOG4105CJ1 ABC, transporter F3L01_08840 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) F3L01_08865 ENOG4108IJ0 Aspartate ammonia-lyase F3L01_08870 ENOG4105C6K Malic enzyme F3L01_08925 ENOG4105FVX F3L01_08930 ENOG4105E09 nadh pyrophosphatase F3L01_08945 ENOG4105CSR polyphosphate kinase 2 F3L01_08950 ENOG4105U3E Transcriptional regulator F3L01_08965 ENOG4105DXI Major Facilitator superfamily F3L01_08975 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) F3L01_08980 ENOG4105EU0 Major facilitator Superfamily F3L01_08985 ENOG4105C6T cysteine synthase F3L01_09005 ENOG4105C8J )-transporter F3L01_09015 ENOG4105X5K response regulator receiver protein F3L01_09020 ENOG4105H67 Protein of unknown function (DUF421) F3L01_09040 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) F3L01_09045 ENOG4105CHR reductase F3L01_09050 ENOG4105CM2 brancheD-chain amino acid aminotransferase F3L01_09055 ENOG4105C7K acetolactate synthase F3L01_09065 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase F3L01_09070 ENOG4105C01 Dihydroxy-acid dehydratase F3L01_09075 ENOG4105C7B Threonine dehydratase F3L01_09105 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b F3L01_09115 ENOG4105DY9 regulatoR F3L01_09120 ENOG4105CYC Transferase F3L01_09135 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) F3L01_09165 ENOG41068WN F3L01_09190 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) F3L01_09205 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) F3L01_09210 ENOG4105C0X amino acid F3L01_09235 ENOG4105K8R UPF0145 protein F3L01_09250 ENOG4107RHR regulatoR F3L01_09260 ENOG4105D9N nucleoside F3L01_09265 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) F3L01_09315 ENOG4107RAQ aminopeptidase F3L01_09325 ENOG4107R16 Multicopper oxidase F3L01_09370 ENOG4108T5E Copper resistance protein F3L01_09375 ENOG4105KTB nuclear export factor GLE1 F3L01_09380 ENOG4107RT3 EamA-like transporter family F3L01_09385 ENOG4105GZI Transcriptional regulator F3L01_09390 ENOG4108Z40 Transcriptional regulator F3L01_09395 ENOG4107ZXU DSBA oxidoreductase F3L01_09400 ENOG4108TVJ Nitroreductase F3L01_09405 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) F3L01_09410 ENOG4106F5Q Membrane F3L01_09415 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) F3L01_09430 ENOG4105CKI cobalamin synthesis protein F3L01_09440 ENOG4105C0Z ABC transporter F3L01_09445 ENOG4108IV0 ABC, transporter F3L01_09450 ENOG4105C32 Amino acid ABC transporter (Permease) F3L01_09460 ENOG4105SKE transcriptional Regulator LysR family F3L01_09480 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes F3L01_09490 ENOG4105C4M (Ubiquinol oxidase) subunit I F3L01_09495 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii F3L01_09500 ENOG4108JJ9 ABC, transporter F3L01_09505 ENOG4108JJ8 (ABC) transporter F3L01_09515 ENOG4105K64 Glycosyl transferase, family 2 F3L01_09525 ENOG4108UT6 Transferase hexapeptide repeat containing protein F3L01_09580 ENOG4105BZ1 (ABC) transporter F3L01_09585 ENOG4105EFI regulatoR F3L01_09590 ENOG4105BZU Histidine kinase F3L01_09605 ENOG41075D4 Aminoglycoside 6-adenylyltransferase F3L01_09630 ENOG4105D6E homoserine dehydrogenase F3L01_09655 ENOG4108KGH TRANSCRIPTIONal F3L01_09665 ENOG4105DPZ Two component transcriptional regulator (Winged helix family F3L01_09670 ENOG4105BZU Histidine kinase F3L01_09685 ENOG4105KT7 mgtC SapB transporter F3L01_09690 ENOG4105VRR gCN5-related N-acetyltransferase F3L01_09700 ENOG4105DUU IucA IucC family protein F3L01_09705 ENOG4105CEY Amp-dependent synthetase and ligase F3L01_09720 ENOG4108WBH protein TIM barrel F3L01_09725 ENOG4105YWU small acid-soluble spore protein F3L01_09735 ENOG4108ZUB Lysine exporter protein (Lyse ygga) F3L01_09740 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family F3L01_09790 ENOG4105KRN Transcriptional regulator, abrb family F3L01_09800 ENOG4105YVS arsR family transcriptional regulator F3L01_09805 ENOG4105CPC Aldo Keto reductase F3L01_09810 ENOG4107XZQ multidrug resistance protein F3L01_09820 ENOG4105KAF membrAne F3L01_09845 ENOG4105C8Q Methyl-accepting chemotaxis F3L01_09860 ENOG4108K88 Membrane F3L01_09865 ENOG4108WPJ Ferritin-like domain F3L01_09880 ENOG4105DEN Luciferase family F3L01_09895 ENOG4105VMI -acetyltransferase F3L01_09900 ENOG4107QM2 Aldo Keto reductase F3L01_09905 ENOG4105CKI cobalamin synthesis protein F3L01_09915 ENOG4105DSE periplasmic solute binding protein F3L01_09920 ENOG4105K4T epimerase F3L01_09930 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) F3L01_09975 ENOG4107T5V SNARE associated Golgi F3L01_09990 ENOG4108PJD permease F3L01_10010 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) F3L01_10030 ENOG4105SXS Protein of unknown function (DUF456) F3L01_10035 ENOG4105C37 (CBS) domain F3L01_10055 ENOG4108Z7R Chaperone CsaA F3L01_10075 ENOG4108ZRV stage ii sporulation protein p F3L01_10085 ENOG4108VXD carboxy-peptidase F3L01_10095 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) F3L01_10145 ENOG4105D6J arsenicaL-resistance protein F3L01_10150 ENOG41082YX Transcriptional regulator, arsr family F3L01_10220 ENOG4108ZRV stage ii sporulation protein p F3L01_10230 ENOG4108X4Q Hydrolase F3L01_10245 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) F3L01_10265 ENOG41087PP glycosyltransferase MGT family F3L01_10270 ENOG4108JYZ YitT family F3L01_10275 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family F3L01_10305 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) F3L01_10340 ENOG4108MGT Required for secretion of EsxA and EsxB F3L01_10420 ENOG4105KBJ sporulation protein ytfj F3L01_10445 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) F3L01_10465 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) F3L01_10470 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily F3L01_10480 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein F3L01_10485 ENOG4105EMN RNA polymerase sigma factor F3L01_10495 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) F3L01_10505 ENOG4105CNW domain protein F3L01_10515 ENOG4108V06 Glutathione peroxidase F3L01_10540 ENOG4108IUE nitrate reductase beta subunit F3L01_10545 ENOG4105R3A Nitrate reductase F3L01_10555 ENOG4107V6Q Cyclic nucleotide-binding domain F3L01_10560 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) F3L01_10565 ENOG4105D06 uba thif-type nad fad binding protein F3L01_10570 ENOG4105CVM Molybdenum cofactor synthesis domain protein F3L01_10575 ENOG4108ZAF Molybdopterin F3L01_10610 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein F3L01_10615 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein F3L01_10620 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) F3L01_10625 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit F3L01_10630 ENOG4108IFG nitrite reductase, (NAD(P)H) F3L01_10635 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) F3L01_10670 ENOG4105MCT stage V sporulation protein S F3L01_10730 ENOG4108UUM single-stranded DNA-binding protein F3L01_10750 ENOG4107YX5 Pfam:DUF548 F3L01_10755 ENOG4105C75 arginyL-tRNA synthetase F3L01_10780 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) F3L01_10795 ENOG4105C5S asparaginyl-tRNA synthetase F3L01_10800 ENOG4105C8J )-transporter F3L01_10820 ENOG4107XGZ Hydrolase F3L01_10825 ENOG4105CY2 Citrate transporter F3L01_10845 ENOG4105KD7 acetyltransferase F3L01_10855 ENOG4105VMP Transcriptional regulator F3L01_10860 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase F3L01_10885 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 F3L01_10900 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) F3L01_10910 ENOG4105EKQ RNA-directed DNA polymerase F3L01_10925 ENOG4107RVG penicillin-binding protein F3L01_10930 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) F3L01_10935 ENOG4105E9Q Acyl-transferase F3L01_10940 ENOG4108UT2 hemolysin iii F3L01_10950 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) F3L01_10960 ENOG4108RCR degv family F3L01_10970 ENOG4108KF3 Electron transport protein SCO1 SenC F3L01_10975 ENOG4107Y70 Heat shock protein F3L01_10980 ENOG4105CAQ asparagine synthetase F3L01_11005 ENOG4105F0I Aminotransferase F3L01_11040 ENOG4105D8X mechanosensitive ion channel F3L01_11045 ENOG4105BZU Histidine kinase F3L01_11055 ENOG4106KNT transcriptional regulator F3L01_11130 ENOG4105E90 ABC transporter F3L01_11165 ENOG4105C37 (CBS) domain F3L01_11190 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) F3L01_11205 ENOG4107S4Y M20 DapE family protein YgeY F3L01_11210 ENOG4108TSC N-acetyltransferase F3L01_11215 ENOG4108JUB Transcriptional regulator F3L01_11220 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein F3L01_11265 ENOG410841Q phosphoesterase PA-phosphatase related protein F3L01_11275 ENOG4105SZ6 Thioredoxin F3L01_11385 ENOG4105BZ4 penicillin-binding protein F3L01_11395 ENOG4105CZM Major Facilitator F3L01_11400 ENOG4105W8X HesB YadR YfhF-family protein F3L01_11410 ENOG4105DXD 2-methylcitrate dehydratase F3L01_11415 ENOG4105CR4 methylisocitrate lyase F3L01_11420 ENOG4105C1G acyl-Coa dehydrogenase F3L01_11425 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase F3L01_11435 ENOG4105N14 lysine exporter protein LysE YggA F3L01_11440 ENOG4105E39 Enoyl-CoA hydratase F3L01_11455 ENOG4107RFY SbcCD D subunit F3L01_11460 ENOG4105EYH Exonuclease F3L01_11480 ENOG4105FCD Major Facilitator F3L01_11490 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase F3L01_11495 ENOG4105E4F Isochorismate synthase F3L01_11500 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase F3L01_11505 ENOG4105WQI isochorismatase F3L01_11510 ENOG4105CEY Amp-dependent synthetase and ligase F3L01_11515 ENOG4105WQT MbtH domain protein F3L01_11520 ENOG4105C0R drug resistance transporter emrb qaca subfamily F3L01_11535 ENOG4105K70 DNA-binding protein F3L01_11555 ENOG4105BZG amino acid carrier protein F3L01_11575 ENOG4105FE9 pseudouridine synthase F3L01_11585 ENOG4105C19 ABC transporter F3L01_11640 ENOG41081I9 integral membrane protein F3L01_11670 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) F3L01_11680 ENOG4105EYF MMPL domain protein F3L01_11740 ENOG4105C1Q protoporphyrinogen oxidase F3L01_11750 ENOG41068WN F3L01_11810 ENOG4108RPX mosc domain containing protein F3L01_11830 ENOG4105BZ1 (ABC) transporter F3L01_11865 ENOG4108JCI Transcriptional regulator F3L01_11895 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) F3L01_11900 ENOG4108KPJ rna polymerase sigma factor F3L01_11920 ENOG4105F32 YngK protein F3L01_11940 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) F3L01_11945 ENOG4105RD7 BadF BadG BcrA BcrD F3L01_11950 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) F3L01_11955 ENOG4107STF Involved in phosphonate degradation (By similarity) F3L01_11965 ENOG4108INS Transcriptional regulator F3L01_11985 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) F3L01_11995 ENOG4105C1J atp-dependent rna helicase F3L01_12005 ENOG4108RZE Tetr family transcriptional regulator F3L01_12125 ENOG41088CC tellurite resistance protein tehB F3L01_12135 ENOG4108I0C methyltransferase F3L01_12140 ENOG4107RA9 decarboxylase F3L01_12145 ENOG4105K56 Transcriptional regulator F3L01_12150 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) F3L01_12175 ENOG4105CIN aminoacyl-histidine dipeptidase F3L01_12200 ENOG4105KRN Transcriptional regulator, abrb family F3L01_12215 ENOG4105EJ9 Membrane F3L01_12220 ENOG4105EQK -acetyltransferase F3L01_12415 ENOG4107RF6 penicillin-binding protein F3L01_12430 ENOG4105DIN metallophosphoesterase F3L01_12440 ENOG4105CJ1 ABC, transporter F3L01_12450 ENOG4107Z3H Transcriptional regulator, TetR family F3L01_12465 ENOG4105C1G acyl-Coa dehydrogenase F3L01_12470 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase F3L01_12475 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit F3L01_12480 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase F3L01_12485 ENOG4105E39 Enoyl-CoA hydratase F3L01_12490 ENOG4107QX3 carboxylase F3L01_12495 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) F3L01_12540 ENOG4105DZ1 carboxypeptidase F3L01_12555 ENOG4105T9C HD domain F3L01_12565 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) F3L01_12585 ENOG41075H3 AraC family transcriptional regulator F3L01_12615 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) F3L01_12645 ENOG4105MDS 4-oxalocrotonate tautomerase F3L01_12650 ENOG4107V2S Transcriptional regulator F3L01_12685 ENOG4105EFA 4-hydroxyphenylacetate F3L01_12700 ENOG4105CPQ Dehydrogenase F3L01_12710 ENOG410900G Protein of unknown function (DUF421) F3L01_12715 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) F3L01_12725 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein F3L01_12735 ENOG4105DK7 lysyl-tRNA synthetase F3L01_12745 ENOG4108VQT Alpha beta hydrolase fold protein F3L01_12805 ENOG4105D6E homoserine dehydrogenase F3L01_12815 ENOG4105CPF Cell wall formation (By similarity) F3L01_12820 ENOG4105ETU transcriptional activator (TenA F3L01_12920 ENOG410667J hydrolase F3L01_12925 ENOG4105BZU Histidine kinase F3L01_12930 ENOG4107RF6 penicillin-binding protein F3L01_12955 ENOG4108FPN Integrase F3L01_12975 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) F3L01_12990 ENOG41086D8 Transcriptional regulator F3L01_13025 ENOG4108NHD germination protein F3L01_13040 ENOG4108W2Y isochorismatase F3L01_13065 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) F3L01_13075 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) F3L01_13120 ENOG4108JJB ABC transporter F3L01_13135 ENOG4108HGU Histidine kinase F3L01_13150 ENOG4105CB2 alcohol dehydrogenase F3L01_13155 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase F3L01_13160 ENOG4105CJN penicillin-binding protein F3L01_13210 ENOG4107Y80 Major Facilitator superfamily F3L01_13225 ENOG4107VXM glycerophosphoryl diester phosphodiesterase F3L01_13250 ENOG4107Y9U Membrane F3L01_13290 ENOG4105FCD Major Facilitator F3L01_13305 ENOG4105E09 nadh pyrophosphatase F3L01_13310 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) F3L01_13330 ENOG4105KME endoribonuclease L-psp F3L01_13335 ENOG4108XI2 Domain of unknown function (DUF1963) F3L01_13355 ENOG4108NRW Phospholipase, patatin family F3L01_13360 ENOG4105KWG Pfam:DUF1696 F3L01_13385 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) F3L01_13395 ENOG4105PKS Excinuclease abc c subunit domain protein F3L01_13425 ENOG4105CJ1 ABC, transporter F3L01_13445 ENOG4107VFR oxidoreductase F3L01_13500 ENOG4108IUM Glycogen debranching enzyme F3L01_13510 ENOG4105CGH 5'-nucleotidase F3L01_13525 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) F3L01_13530 ENOG4105FDR Membrane F3L01_13540 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) F3L01_13615 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) F3L01_13620 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) F3L01_13625 ENOG4107Z3H Transcriptional regulator, TetR family F3L01_13650 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family F3L01_13665 ENOG4105E98 transcriptional regulator DeoR family F3L01_13680 ENOG41062ES Transcriptional regulator F3L01_13700 ENOG4107QKR Dehydrogenase F3L01_13710 ENOG4107RUY (E1 component), alpha subunit F3L01_13720 ENOG4105E1F short-chain dehydrogenase reductase F3L01_13750 ENOG4107SQ8 Glycine betaine F3L01_13755 ENOG4108IJ7 Glycine betaine F3L01_13765 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) F3L01_13785 ENOG41082BV acetyltransferase F3L01_13790 ENOG4108M1A Chitin-binding protein F3L01_13820 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) F3L01_13825 ENOG4105MSB protein, conserved in bacteria F3L01_13845 ENOG4108Z7F N-acetyltransferase F3L01_13865 ENOG4105EEM helicase F3L01_13895 ENOG4105C9U ATP-dependent DNA helicase RecQ F3L01_13945 ENOG4108M1A Chitin-binding protein F3L01_13965 ENOG4105BZG amino acid carrier protein F3L01_13975 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) F3L01_13980 ENOG4105CTU Proline racemase F3L01_13985 ENOG4105CTU Proline racemase F3L01_13990 ENOG41080HI glycine oxidase F3L01_14000 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein F3L01_14030 ENOG4105DCI Phosphohydrolase F3L01_14035 ENOG4107T5V SNARE associated Golgi F3L01_14065 ENOG4105DTQ mandelate racemase muconate lactonizing F3L01_14080 ENOG4107SET aldo keto reductase F3L01_14115 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) F3L01_14120 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) F3L01_14125 ENOG4105BZU Histidine kinase F3L01_14130 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L01_14155 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 F3L01_14175 ENOG4105EPR degv family F3L01_14235 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) F3L01_14240 ENOG4106K7D Major facilitator family transporter F3L01_14260 ENOG4107BMA Transglycosylase associated protein F3L01_14275 ENOG41089UC methyltransferase, type 11 F3L01_14310 ENOG4105CHM Aminotransferase F3L01_14325 ENOG4108ZMI UPF0477 protein F3L01_14365 ENOG4105C02 permease F3L01_14375 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) F3L01_14380 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component F3L01_14385 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein F3L01_14390 ENOG4105D7T ABC transporter F3L01_14425 ENOG4108AQF aminoglycoside N(3)-acetyltransferase F3L01_14465 ENOG4107VC0 DNA alkylation repair enzyme F3L01_14470 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase F3L01_14490 ENOG4108ZCF integral membrane protein F3L01_14495 ENOG4105E0M Sulfatase F3L01_14500 ENOG4105C5H ABC transporter F3L01_14575 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) F3L01_14585 ENOG4105EYF MMPL domain protein F3L01_14590 ENOG41082JN Transcriptional regulator F3L01_14610 ENOG4105CIH Imidazole acetol-phosphate transaminase F3L01_14615 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase F3L01_14620 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase F3L01_14645 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) F3L01_14670 ENOG41069ER domain protein F3L01_14680 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase F3L01_14685 ENOG4105DNP FAD linked oxidase domain protein F3L01_14710 ENOG4105D4B ABC, transporter F3L01_14715 ENOG4105F5R ABC transporter F3L01_14720 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane F3L01_14730 ENOG4105DKT Transcriptional regulator F3L01_14735 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) F3L01_14745 ENOG41061GT Aldolase F3L01_14760 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) F3L01_14795 ENOG4105II7 pyrroline-5-carboxylate reductase F3L01_14805 ENOG4107258 Transcriptional regulator F3L01_14825 ENOG4105ECK Fatty Acid Desaturase F3L01_14835 ENOG4107RBI VanW family F3L01_14840 ENOG4105G6Z alkaline phosphatase F3L01_14850 ENOG4105VMP Transcriptional regulator F3L01_14870 ENOG41068WN F3L01_14900 ENOG4105C7R Atpase associated with various cellular activities aaa_3 F3L01_14915 ENOG4105CSH Transporter F3L01_14925 ENOG4105CKK Glycosyl transferase, family 2 F3L01_14960 ENOG4105C8Y Acetylornithine aminotransferase F3L01_15005 ENOG4105C7R Atpase associated with various cellular activities aaa_3 F3L01_15100 ENOG4108TVJ Nitroreductase F3L01_15105 ENOG4105FS7 Transcriptional regulator F3L01_15125 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) F3L01_15130 ENOG4105WEC Molybdate metabolism regulator F3L01_15135 ENOG4105CMR udp-glucose 4-epimerase F3L01_15140 ENOG4105C19 ABC transporter F3L01_15165 ENOG4108DMH HTH_ARAC F3L01_15170 ENOG4108XET gCN5-related N-acetyltransferase F3L01_15245 ENOG410635A Membrane F3L01_15255 ENOG4108IQI permease F3L01_15265 ENOG4105F1N DNA alkylation repair F3L01_15305 ENOG4107RF6 penicillin-binding protein F3L01_15335 ENOG4105E7W lamb ycsf family protein F3L01_15345 ENOG4105P4J Allophanate hydrolase, subunit 1 F3L01_15350 ENOG4107258 Transcriptional regulator F3L01_15360 ENOG4106N3A copper homeostasis protein cutc F3L01_15365 ENOG4108ZHR arsR family transcriptional regulator F3L01_15375 ENOG4105FDT acyl-CoA dehydrogenase F3L01_15390 ENOG4105DWD nucleoside recognition domain protein F3L01_15435 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) F3L01_15460 ENOG4105E2A Dehydrogenase F3L01_15470 ENOG4108IJ0 Aspartate ammonia-lyase F3L01_15475 ENOG4105HDK L-asparaginase F3L01_15480 ENOG4108IMY Transcriptional regulator F3L01_15505 ENOG4108B31 Spore germination protein F3L01_15515 ENOG4105BZU Histidine kinase F3L01_15540 ENOG41075H3 AraC family transcriptional regulator F3L01_15555 ENOG4105YWU small acid-soluble spore protein F3L01_15565 ENOG4105CUB amino acid F3L01_15570 ENOG4105II7 pyrroline-5-carboxylate reductase F3L01_15575 ENOG4108NHD germination protein F3L01_15580 ENOG4108Q8B Spore germination protein F3L01_15640 ENOG4105CGH 5'-nucleotidase F3L01_15650 ENOG4105CHJ isochorismatase hydrolase F3L01_15675 ENOG41090MY MarR family Transcriptional regulator F3L01_15700 ENOG4105F6J Alpha beta hydrolase fold F3L01_15720 ENOG4105CVP deoxyribo-dipyrimidine photolyase F3L01_15745 ENOG4108TWJ NADH dehydrogenase subunit 5 F3L01_15750 ENOG4105GPN Uncharacterized conserved protein (DUF2294) F3L01_15770 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase F3L01_15795 ENOG4105Z7P Acetyltransferase (GNAT) family F3L01_15805 ENOG4105D6J arsenicaL-resistance protein F3L01_15810 ENOG41085FC arsR family transcriptional regulator F3L01_15820 ENOG4105NAE bifunctional deaminase-reductase domain protein F3L01_15825 ENOG4107P5I polyketide synthase F3L01_15830 ENOG4108IG5 Transcriptional regulator F3L01_15835 ENOG4105CHR reductase F3L01_15840 ENOG4108YXU transcriptional regulator AsnC family F3L01_15855 ENOG4105D7V transposase F3L01_15990 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) F3L01_15995 ENOG4105C0R drug resistance transporter emrb qaca subfamily F3L01_16015 ENOG4105K6H D-cysteine desulfhydrase F3L01_16025 ENOG4105E0Y RtcB Protein F3L01_16035 ENOG4105JQZ Methyltransferase F3L01_16050 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) F3L01_16070 ENOG4105BZU Histidine kinase F3L01_16080 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) F3L01_16110 ENOG4108JQ1 Dehydrogenase F3L01_16115 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) F3L01_16130 ENOG41082W1 Cupin 2, conserved barrel domain protein F3L01_16140 ENOG410874W AraC family transcriptional regulator F3L01_16160 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase F3L01_16380 ENOG4108VXD carboxy-peptidase F3L01_16385 ENOG4105PNM synthesis protein F3L01_16395 ENOG4108ISG Major Facilitator F3L01_16410 ENOG4107MII Sugar-specific transcriptional regulator TrmB F3L01_16415 ENOG4105CZM Major Facilitator F3L01_16425 ENOG4105CRW Short chain fatty acid transporter F3L01_16435 ENOG4105DYS nad(p)h dehydrogenase (quinone) F3L01_16495 ENOG4108K8S endonuclease I F3L01_16520 ENOG4108Z66 YbaK ebsC protein F3L01_16525 ENOG4105CUT histidyl-tRNA synthetase F3L01_16540 ENOG4105KVH Transcriptional regulator F3L01_16545 ENOG4108RCM Nitroreductase F3L01_16575 ENOG4108PSK reductase F3L01_16655 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) F3L01_16715 ENOG4105C37 (CBS) domain F3L01_16730 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase F3L01_16735 ENOG4105FAW cDP-glucose 4,6-dehydratase F3L01_16770 ENOG4105DDN Pentapeptide repeat-containing protein F3L01_16775 ENOG4105XDF Protein of unknown function (DUF1272) F3L01_16780 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) F3L01_16785 ENOG4105CMG Carbohydrate kinase F3L01_16805 ENOG4105CV1 Transketolase (EC 2.2.1.1) F3L01_16810 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase F3L01_16815 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase F3L01_16820 ENOG4105CIS alcohol dehydrogenase F3L01_16825 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone F3L01_16845 ENOG4105EWI Short-chain dehydrogenase reductase Sdr F3L01_16860 ENOG4105C8Q Methyl-accepting chemotaxis F3L01_16865 ENOG4108UX3 '-nucleotidase F3L01_16870 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) F3L01_16875 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) F3L01_16880 ENOG4105KVH Transcriptional regulator F3L01_16895 ENOG4105CV8 reductase F3L01_16900 ENOG4105F27 Major Facilitator F3L01_16910 ENOG41090KN UPF0303 protein F3L01_16925 ENOG4105C44 Serine transporter F3L01_16955 ENOG4105KVH Transcriptional regulator F3L01_16960 ENOG4108TZY GntR Family Transcriptional Regulator F3L01_16965 ENOG4105D9R oxidoreductase F3L01_16970 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase F3L01_16975 ENOG4105KVH Transcriptional regulator F3L01_16980 ENOG4105KVH Transcriptional regulator F3L01_17020 ENOG4105JAB phenazine biosynthesis protein, phzf family F3L01_17030 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein F3L01_17035 ENOG4105KVH Transcriptional regulator F3L01_17055 ENOG4108ZJ4 polysaccharide deacetylase F3L01_17075 ENOG410829K Lysine exporter protein (Lyse ygga) F3L01_17135 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) F3L01_17145 ENOG4107YXZ hydrolase, family 25 F3L01_17175 ENOG4105H3G oxidoreductase F3L01_17245 ENOG4108TN2 lmbE family F3L01_17255 ENOG4107R3E Citrate transporter F3L01_17270 ENOG4108MES Periplasmic binding protein F3L01_17275 ENOG4105EHG Permease protein F3L01_17280 ENOG4105DQ5 transport system permease protein F3L01_17285 ENOG4105NX3 Membrane F3L01_17305 ENOG4107CUJ Protein of unknown function (DUF2690) F3L01_17315 ENOG4107V2S Transcriptional regulator F3L01_17345 ENOG4105E5K Alpha-amylase F3L01_17350 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase F3L01_17355 ENOG4105DPN Oligoendopeptidase f F3L01_17360 ENOG4108A04 Beta-lactamase F3L01_17385 ENOG4107VXM glycerophosphoryl diester phosphodiesterase F3L01_17395 ENOG41082BM Transcriptional regulator, arsr family F3L01_17400 ENOG4105CIS alcohol dehydrogenase F3L01_17405 ENOG4105CNG UPF0061 protein F3L01_17440 ENOG4105CQB FAD linked oxidase domain protein F3L01_17465 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase F3L01_17475 ENOG4107TPS domain protein F3L01_17480 ENOG4105CEP NADH dehydrogenase F3L01_17490 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase F3L01_17500 ENOG4108IAJ Nad-dependent epimerase dehydratase F3L01_17505 ENOG4105FAW cDP-glucose 4,6-dehydratase F3L01_17555 ENOG4105BZU Histidine kinase F3L01_17560 ENOG4105C5H ABC transporter F3L01_17570 ENOG4107DUR UPF0457 protein F3L01_17590 ENOG4105BZU Histidine kinase F3L01_17600 ENOG4105KT7 mgtC SapB transporter F3L01_17610 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase F3L01_17615 ENOG41073R8 VanW family F3L01_17625 ENOG4108R1P F3L01_17640 ENOG4105VEQ Cold shock protein F3L01_17660 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) F3L01_17680 ENOG410904N short-chain dehydrogenase reductase F3L01_17690 ENOG4106IQC argininosuccinate lyase F3L01_17705 ENOG4108IA2 Sodium pantothenate symporter F3L01_17755 ENOG4105CHR reductase F3L01_17765 ENOG4105EWU Squalene--hopene cyclase F3L01_17775 ENOG4105FR1 rard protein F3L01_17780 ENOG410696E Membrane F3L01_17795 ENOG4105D1F ATP-binding protein F3L01_17805 ENOG4108ZAF Molybdopterin F3L01_17810 ENOG4105CVM Molybdenum cofactor synthesis domain protein F3L01_17815 ENOG4105D06 uba thif-type nad fad binding protein F3L01_17820 ENOG4105TMB Formate nitrite transporter F3L01_17830 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) F3L01_17835 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) F3L01_17845 ENOG4108JB9 formate dehydrogenase F3L01_17850 ENOG4105E1K spore germination protein F3L01_17865 ENOG4105CUB amino acid F3L01_17925 ENOG4108KGH TRANSCRIPTIONal F3L01_17935 ENOG4105EMN RNA polymerase sigma factor F3L01_17945 ENOG4105CIG ABC transporter F3L01_17955 ENOG4105D9R oxidoreductase F3L01_17965 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) F3L01_17970 ENOG4105K4P CoA-binding domain protein F3L01_17975 ENOG4105C0H protease F3L01_17980 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L01_17990 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase F3L01_18000 ENOG4105W8X HesB YadR YfhF-family protein F3L01_18010 ENOG4105D7V transposase F3L01_18035 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) F3L01_18040 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen F3L01_18050 ENOG4108JJA ABC, transporter F3L01_18055 ENOG4108I0Z Aconitate hydratase F3L01_18085 ENOG4105E5W Transporter F3L01_18095 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) F3L01_18115 ENOG4107F3J Amp-dependent synthetase and ligase F3L01_18120 ENOG4107ZYJ bioY protein F3L01_18125 ENOG4105CEY Amp-dependent synthetase and ligase F3L01_18130 ENOG4108IMY Transcriptional regulator F3L01_18170 ENOG4107AYK membrAne F3L01_18185 ENOG4105BZU Histidine kinase F3L01_18190 ENOG4105FBA Phospholipase Carboxylesterase F3L01_18200 ENOG4105CK7 Sodium proline symporter F3L01_18205 ENOG4105CBC glutamate synthase F3L01_18210 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase F3L01_18215 ENOG4108VJ1 Transcriptional regulator (CarD family F3L01_18280 ENOG4107QIV Cytochrome c biogenesis protein F3L01_18305 ENOG4105CJ1 ABC, transporter F3L01_18320 ENOG4107RSM transcriptional regulator F3L01_18330 ENOG41067MG lrgb family F3L01_18370 ENOG4105BZ1 (ABC) transporter F3L01_18375 ENOG4105BZ1 (ABC) transporter F3L01_18410 ENOG4108HW3 (ABC) transporter F3L01_18425 ENOG4108SVB resolvase F3L01_18445 ENOG4105K7K Transcriptional regulator F3L01_18450 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase F3L01_18470 ENOG4105E4C Lytic transglycosylase catalytic F3L01_18475 ENOG41065S2 pneumococcal vaccine antigen F3L01_18550 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase F3L01_18555 ENOG4105XSJ toxin secretion phage lysis holin F3L01_18825 ENOG4105C5F glutamine synthetase F3L01_18830 ENOG4105KV4 Transcriptional regulator F3L01_18835 ENOG4105CXI aluminum resistance protein F3L01_18840 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) F3L01_18845 ENOG4105EN6 Membrane F3L01_18850 ENOG4106F1P AAA ATPase, central domain protein F3L01_18880 ENOG41069ER domain protein F3L01_18890 ENOG4105DM4 PTS System F3L01_18895 ENOG4105DE4 1-phosphofructokinase F3L01_18900 ENOG4105E98 transcriptional regulator DeoR family F3L01_18905 ENOG4107QW4 alcohol dehydrogenase F3L01_18910 ENOG4108SJC Membrane F3L01_18920 ENOG4105C85 amino acid F3L01_18940 ENOG4105TMB Formate nitrite transporter F3L01_18945 ENOG4105K70 DNA-binding protein F3L01_18955 ENOG4105C59 p-type ATPase F3L01_18960 ENOG410681U heavy metal transport detoxification protein F3L01_18965 ENOG4105VPX protein, conserved in bacteria F3L01_18975 ENOG4105NIV Esterase F3L01_18980 ENOG4105E0A ABC, transporter F3L01_19000 ENOG4105CGK Exodeoxyribonuclease III F3L01_19010 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) F3L01_19015 ENOG4105D03 DNA-3-methyladenine glycosylase II F3L01_19020 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) F3L01_19040 ENOG4105BZU Histidine kinase F3L01_19080 ENOG41067MG lrgb family F3L01_19100 ENOG4108S3Y transcriptional regulator F3L01_19105 ENOG4105CS2 ec 3.2.1.21 F3L01_19120 ENOG4105F0V Cell wall hydrolase F3L01_19135 ENOG4105E0M Sulfatase F3L01_19140 ENOG410890F Dynamin family F3L01_19170 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) F3L01_19175 ENOG4105DQU oxidoreductase, subunit beta F3L01_19180 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein F3L01_19185 ENOG4108IGT Dipeptidase F3L01_19190 ENOG4105MCT stage V sporulation protein S F3L01_19195 ENOG4105D48 metallophosphoesterase F3L01_19210 ENOG4105CEV competence damage-inducible protein F3L01_19215 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase F3L01_19230 ENOG4105XZV Protein of unknown function (DUF3243) F3L01_19235 ENOG4108RKS Short-chain dehydrogenase reductase Sdr F3L01_19255 ENOG4105UIB (ABC) transporter F3L01_19260 ENOG4108JQ9 ABC transporter F3L01_19265 ENOG4105DIH basic membrane F3L01_19270 ENOG4105FDP GntR family transcriptional regulator F3L01_19280 ENOG4107QZI cell division protein FtsK F3L01_19290 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit F3L01_19300 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) F3L01_19310 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) F3L01_19315 ENOG4108S0H Dipicolinic acid synthetase, b subunit F3L01_19320 ENOG4105E35 Dipicolinate synthase subunit A F3L01_19330 ENOG4105C1V Peptidase, M16 F3L01_19350 ENOG4105DTN riboflavin biosynthesis protein ribF F3L01_19365 ENOG4105W7A Protein of unknown function (DUF503) F3L01_19375 ENOG4105VHM ribosomal protein F3L01_19380 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination F3L01_19385 ENOG4105CHV Transcription elongation factor NusA F3L01_19395 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) F3L01_19405 ENOG4105DZP Membrane-associated zinc metalloprotease F3L01_19410 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) F3L01_19415 ENOG4105KNE Phosphatidate cytidylyltransferase F3L01_19420 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) F3L01_19430 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) F3L01_19460 ENOG4108HE4 integrase family F3L01_19470 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) F3L01_19475 ENOG4105C79 DNA protecting protein DprA F3L01_19480 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha F3L01_19495 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) F3L01_19520 ENOG4105VB6 UPF0109 protein F3L01_19540 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) F3L01_19545 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) F3L01_19560 ENOG4105CHR reductase F3L01_19565 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase F3L01_19580 ENOG4105CB5 ATP-dependent DNA helicase recG F3L01_19585 ENOG4105DP4 dak2 domain fusion protein ylov F3L01_19590 ENOG4108ZAA Alkaline-shock protein F3L01_19605 ENOG4105FJ0 thiamine F3L01_19610 ENOG4105DJV ribulose-phosphate 3-epimerase F3L01_19615 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) F3L01_19620 ENOG4105D9P serine threonine protein kinase F3L01_19625 ENOG4108ZF3 Phosphatase F3L01_19630 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs F3L01_19635 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B F3L01_19650 ENOG4105C25 Primosomal protein n' F3L01_19655 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase F3L01_19675 ENOG4105DSJ YicC domain protein F3L01_19695 ENOG4105DC7 peptidase M24 F3L01_19735 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) F3L01_19750 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) F3L01_19755 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain F3L01_19765 ENOG4105CD3 dihydroorotase F3L01_19785 ENOG4105C34 Pseudouridine synthase F3L01_19810 ENOG4105DBK s4 domain protein F3L01_19815 ENOG41067XK integral membrane protein F3L01_19825 ENOG4105DFA alanine racemase domain protein F3L01_19830 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase F3L01_19835 ENOG4105WR5 sporulation protein, YlmC YmxH family F3L01_19845 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F3L01_19855 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) F3L01_19860 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) F3L01_19870 ENOG4105D4A Cell wall formation (By similarity) F3L01_19875 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) F3L01_19880 ENOG4105CNI cell division protein FtsW F3L01_19885 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) F3L01_19895 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) F3L01_19900 ENOG4105CJN penicillin-binding protein F3L01_19905 ENOG4105CJN penicillin-binding protein F3L01_19920 ENOG41074B2 UPF0747 protein F3L01_19945 ENOG4105KNH Nucleic acid-binding protein F3L01_19985 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase F3L01_19990 ENOG4105XSJ toxin secretion phage lysis holin F3L01_20060 ENOG4108N9J Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) F3L01_20070 ENOG4105CAR Terminase, large subunit F3L01_20165 ENOG4105KRN Transcriptional regulator, abrb family F3L01_20190 ENOG4108IMY Transcriptional regulator F3L01_20200 ENOG41067QW Transcriptional regulator F3L01_20220 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) F3L01_20230 ENOG41063PX domain protein F3L01_20235 ENOG4105D78 K07001 NTE family protein F3L01_20240 ENOG4105H20 Sporulation integral membrane protein YlbJ F3L01_20250 ENOG4106H78 methyltransferase F3L01_20270 ENOG4107TB6 phosphoglycerate mutase F3L01_20285 ENOG4106UY4 Inherit from COG: Scp-like extracellular F3L01_20330 ENOG4107VFP cytochrome oxidase assembly F3L01_20335 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) F3L01_20345 ENOG4105CNI cell division protein FtsW F3L01_20360 ENOG4108IAB Phoh family F3L01_20380 ENOG4105QA2 F3L01_20385 ENOG4105CI3 gtp-binding protein typa F3L01_20395 ENOG4105ECY inositol monophosphatase F3L01_20415 ENOG4105CXN decarboxylase F3L01_20465 ENOG4105CPP Dehydrogenase, E1 component F3L01_20480 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) F3L01_20485 ENOG4108X4Q Hydrolase F3L01_20500 ENOG4105CN5 Metallo-Beta-Lactamase F3L01_20505 ENOG4107ZYR domain protein F3L01_20540 ENOG4108XRC Protein of unknown function (DUF458) F3L01_20545 ENOG4107IN1 Protein of unknown function (DUF1797) F3L01_20560 ENOG4105EPM Diguanylate phosphodiesterase F3L01_20565 ENOG4105K6S Short-chain dehydrogenase reductase Sdr F3L01_20580 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) F3L01_20590 ENOG4105UIN F3L01_20630 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) F3L01_20645 ENOG4105EKQ RNA-directed DNA polymerase F3L01_20660 ENOG4108HGU Histidine kinase F3L01_20670 ENOG4105CHM Aminotransferase F3L01_20675 ENOG4105FKQ transcriptional regulator F3L01_20680 ENOG4105EG2 ABC transporter, permease F3L01_20690 ENOG4107FKK extracellular solute-binding protein family 1 F3L01_20700 ENOG4105CG3 alpha amylase, catalytic region F3L01_20745 ENOG4105CHU acetyl-coa acetyltransferase F3L01_20780 ENOG4105K7K Transcriptional regulator F3L01_20785 ENOG4105DTD Dehydrogenase F3L01_20800 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) F3L01_20805 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase F3L01_20815 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate F3L01_20830 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) F3L01_20845 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase F3L01_20855 ENOG4105BZU Histidine kinase F3L01_20875 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) F3L01_20890 ENOG4105CID antiterminator F3L01_20910 ENOG4105CE4 GlcNAc 6-P deacetylase F3L01_20950 ENOG4107ZE5 PPIases accelerate the folding of proteins F3L01_20955 ENOG4105PTM secreted protein F3L01_20960 ENOG4105J7I hydrolase F3L01_20970 ENOG4105G6R Stage v sporulation protein ae F3L01_20980 ENOG4105CZ3 stage V sporulation protein ad F3L01_20985 ENOG41090VF Stage v sporulation protein ac F3L01_21005 ENOG4105C8J )-transporter F3L01_21010 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F3L01_21020 ENOG41082AN stage II sporulation protein F3L01_21025 ENOG4105DZ1 carboxypeptidase F3L01_21035 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family F3L01_21040 ENOG4105DVE abc transporter atp-binding protein F3L01_21075 ENOG4105D7N magnesium and cobalt transport protein CorA F3L01_21100 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) F3L01_21110 ENOG4105I3K Ferric uptake regulator, Fur family F3L01_21115 ENOG4105MZ9 stage II sporulation protein m F3L01_21135 ENOG4105CPC Aldo Keto reductase F3L01_21145 ENOG4105RHY Pfam:UPF0157 F3L01_21165 ENOG4107SKW Inherit from COG: Alpha beta hydrolase F3L01_21175 ENOG4105ETE Transcriptional regulator (LacI family F3L01_21180 ENOG4108YM7 Gcn5-related n-acetyltransferase F3L01_21200 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) F3L01_21205 ENOG4108R6K riboflavin synthase, subunit alpha F3L01_21230 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) F3L01_21235 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) F3L01_21245 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) F3L01_21250 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) F3L01_21260 ENOG4105DFD Na H antiporter F3L01_21265 ENOG4105CGH 5'-nucleotidase F3L01_21290 ENOG4105DBV ornithine carbamoyltransferase F3L01_21305 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) F3L01_21320 ENOG4108IXY short-chain dehydrogenase reductase F3L01_21325 ENOG41069FQ Metallo-beta-lactamase superfamily F3L01_21330 ENOG4105II7 pyrroline-5-carboxylate reductase F3L01_21335 ENOG4105EJQ L-serine dehydratase F3L01_21350 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) F3L01_21370 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) F3L01_21375 ENOG4105D9U N-acetyltransferase F3L01_21390 ENOG4108VZI ErfK ybiS ycfS ynhG family protein F3L01_21395 ENOG4108QEG Membrane F3L01_21400 ENOG4105CDA abc transporter atp-binding protein F3L01_21405 ENOG4105E5Q amino acid AbC transporter F3L01_21410 ENOG4108HW3 (ABC) transporter F3L01_21420 ENOG4105G7B Protein of unknown function (DUF2992) F3L01_21430 ENOG4108QY0 Membrane F3L01_21440 ENOG4105C7S Dehydrogenase F3L01_21445 ENOG4105CPP Dehydrogenase, E1 component F3L01_21460 ENOG4105CKM Branched-chain carboxylic acid kinase F3L01_21465 ENOG4107RDP Dehydrogenase F3L01_21480 ENOG4108JUB Transcriptional regulator F3L01_21490 ENOG4108QXE glycerophosphoryl diester phosphodiesterase F3L01_21505 ENOG4107QQR Sporulation F3L01_21515 ENOG4105S1Z Stage IV sporulation protein B F3L01_21520 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) F3L01_21525 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) F3L01_21530 ENOG4105DX0 Hemolysin A F3L01_21540 ENOG4105CTB Polyprenyl synthetase F3L01_21555 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) F3L01_21565 ENOG4108ZSR alkaline shock protein F3L01_21570 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase F3L01_21595 ENOG410644B Stage III sporulation protein af F3L01_21605 ENOG4105KQ4 Stage iii sporulation protein ad F3L01_21610 ENOG4108CQH stage III sporulation protein AC F3L01_21615 ENOG4105KR5 Stage iii sporulation protein F3L01_21620 ENOG4105CD2 stage iii sporulation protein aa F3L01_21645 ENOG4105DC7 peptidase M24 F3L01_21650 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) F3L01_21660 ENOG4105CBJ Metal-dependent enzyme F3L01_21670 ENOG4107YBY Hydrolase F3L01_21700 ENOG41082GG biotin lipoate A B protein ligase F3L01_21705 ENOG4105WZW rhodanese family F3L01_21730 ENOG41080TC multidrug resistance protein F3L01_21760 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor F3L01_21780 ENOG4105C0D helicase F3L01_21855 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) F3L01_21885 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) F3L01_21955 ENOG4107R6U sodium dicarboxylate symporter F3L01_21990 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) F3L01_21995 ENOG4105C3R Methionine synthase F3L01_22005 ENOG4105C28 cystathionine F3L01_22010 ENOG4105C28 cystathionine F3L01_22030 ENOG4105C5X domain protein F3L01_22040 ENOG4105DKQ ROK family F3L01_22050 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase F3L01_22065 ENOG4108UTW Plays a role in the regulation of phosphate uptake F3L01_22070 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) F3L01_22075 ENOG4105C8U phosphate abc transporter F3L01_22080 ENOG4105C8U phosphate abc transporter F3L01_22085 ENOG4105EXS phosphate abc transporter F3L01_22090 ENOG4107RF6 penicillin-binding protein F3L01_22100 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) F3L01_22125 ENOG4105N80 Ferric uptake regulator, Fur family F3L01_22135 ENOG4105FDK ABC transporter F3L01_22140 ENOG4108JYZ YitT family F3L01_22145 ENOG41069ZM Protein of unknown function (DUF2624) F3L01_22170 ENOG4105EGD dinuclear metal center protein, YbgI family F3L01_22185 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F3L01_22190 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) F3L01_22195 ENOG4107XJU UPF0178 protein F3L01_22220 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) F3L01_22225 ENOG4105KG3 cytidine deaminase F3L01_22230 ENOG4107YR5 Diacylglycerol kinase F3L01_22235 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) F3L01_22240 ENOG4105CTJ Metal Dependent Phosphohydrolase F3L01_22245 ENOG4105C9A Phoh family F3L01_22255 ENOG41068P3 sporulation protein YqfC F3L01_22265 ENOG4105KTH gatB Yqey F3L01_22275 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) F3L01_22280 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) F3L01_22310 ENOG4105CSA Coproporphyrinogen iii oxidase F3L01_22315 ENOG4105KVH Transcriptional regulator F3L01_22340 ENOG4105TQK DNA polymerase iii, delta' subunit F3L01_22350 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 F3L01_22355 ENOG4108UK2 deaminase F3L01_22360 ENOG4105KQC Competence protein F3L01_22370 ENOG4105DXX methyltransferase F3L01_22380 ENOG4108WF2 Metal Dependent Phosphohydrolase F3L01_22390 ENOG410812S Rna-binding protein F3L01_22400 ENOG4105CQW ribosome biogenesis GTPase YqeH F3L01_22405 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase F3L01_22420 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F3L01_22440 ENOG4108TVJ Nitroreductase F3L01_22455 ENOG4105G6Z alkaline phosphatase F3L01_22460 ENOG4105KEG ribosomal-protein-alanine acetyltransferase F3L01_22465 ENOG4108MUZ hydrolase F3L01_22505 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin F3L01_22510 ENOG4105MIR Phenylalanine 4-monooxygenase F3L01_22520 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase F3L01_22565 ENOG4105S6R Iron-hydroxamate transporter permease subunit F3L01_22570 ENOG4108V5C ABC transporter F3L01_22585 ENOG4105C0A alcohol dehydrogenase F3L01_22590 ENOG4105C28 cystathionine F3L01_22620 ENOG4107XRG penicillin-binding protein F3L01_22630 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) F3L01_22640 ENOG4105CFP Peptidase U32 F3L01_22645 ENOG4105XYU peptidase (U32 family) F3L01_22655 ENOG4105HHA aminodeoxychorismate lyase F3L01_22675 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) F3L01_22685 ENOG4105C02 permease F3L01_22700 ENOG41060CR F3L01_22705 ENOG4105C7H Helicase, RecD TraA family F3L01_22715 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) F3L01_22720 ENOG4105C3J Cysteine desulfurase F3L01_22730 ENOG4105D1H recombination factor protein RarA F3L01_22735 ENOG4108VCI transcription factor, rsfa family F3L01_22750 ENOG4105CUZ uba thif-type nad fad binding protein F3L01_22760 ENOG4105CUT histidyl-tRNA synthetase F3L01_22765 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) F3L01_22770 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) F3L01_22780 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) F3L01_22785 ENOG41076HS cation diffusion facilitator family transporter F3L01_22790 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) F3L01_22800 ENOG4105CKP Polysaccharide Biosynthesis Protein F3L01_22805 ENOG4108QG2 Membrane F3L01_22815 ENOG4105VIE preprotein translocase, subunit YajC F3L01_22830 ENOG41061AI Protein of unknown function (DUF2905) F3L01_22845 ENOG4108HUF Transporter F3L01_22870 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) F3L01_22875 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase F3L01_22880 ENOG4108IYU L-aspartate oxidase F3L01_22895 ENOG4108RPX mosc domain containing protein F3L01_22900 ENOG4105CQC Prephenate dehydratase F3L01_22915 ENOG4105C19 ABC transporter F3L01_22920 ENOG4105EWM Histidine kinase F3L01_22930 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control F3L01_22950 ENOG4105C03 ribonuclease F3L01_22965 ENOG4107QMS site-determining protein F3L01_22985 ENOG4105DFF Rod shape-determining protein mreb F3L01_22995 ENOG4108Z03 MAF-like protein F3L01_23005 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase F3L01_23010 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) F3L01_23020 ENOG41068KH stage VI sporulation protein D F3L01_23030 ENOG4105D52 delta-aminolevulinic acid dehydratase F3L01_23055 ENOG4105K56 Transcriptional regulator F3L01_23075 ENOG4108IUQ atp-dependent protease F3L01_23100 ENOG4108QCI YvbH-like oligomerisation region F3L01_23120 ENOG4105M59 Phosphodiesterase, mj0936 family F3L01_23125 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) F3L01_23135 ENOG4108XJQ germination protein F3L01_23145 ENOG4108PCX Major Facilitator F3L01_23155 ENOG4105KBX Transcriptional regulator, TetR family F3L01_23165 ENOG4105PFC Transcriptional regulator F3L01_23175 ENOG4105DZC cytosine deaminase F3L01_23180 ENOG41067S9 phage shock protein C, PspC F3L01_23185 ENOG4108JCI Transcriptional regulator F3L01_23195 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) F3L01_23200 ENOG4108Z40 Transcriptional regulator F3L01_23205 ENOG4105RHA ABC transporter, permease F3L01_23210 ENOG4108IUX (ABC) transporter F3L01_23215 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family F3L01_23220 ENOG4105ER2 Ompa motb domain protein F3L01_23225 ENOG4105E14 MotA TolQ exbB proton channel F3L01_23230 ENOG4108VXD carboxy-peptidase F3L01_23240 ENOG4105E33 succinate dehydrogenase F3L01_23250 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit F3L01_23260 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) F3L01_23265 ENOG4105K63 Thioredoxin F3L01_23270 ENOG4105C10 Electron transfer flavoprotein F3L01_23275 ENOG4105BZJ Electron transfer flavoprotein F3L01_23280 ENOG41060WC Enoyl-CoA hydratase F3L01_23285 ENOG4107Z3H Transcriptional regulator, TetR family F3L01_23290 ENOG4105CEY Amp-dependent synthetase and ligase F3L01_23300 ENOG4105J76 Periplasmic binding protein F3L01_23305 ENOG4105S6R Iron-hydroxamate transporter permease subunit F3L01_23350 ENOG4105DPZ Two component transcriptional regulator (Winged helix family F3L01_23360 ENOG4105DR4 Methyltransferase F3L01_23370 ENOG4105KFN sortase, SrtB family F3L01_23375 ENOG4105E0A ABC, transporter F3L01_23390 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) F3L01_23400 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) F3L01_23410 ENOG4105FE9 pseudouridine synthase F3L01_23420 ENOG4105DCG PHP domain protein F3L01_23435 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) F3L01_23455 ENOG4105C5S asparaginyl-tRNA synthetase F3L01_23460 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) F3L01_23470 ENOG4108RWN rrna methyltransferase F3L01_23500 ENOG4105C0R drug resistance transporter emrb qaca subfamily F3L01_23505 ENOG4105CW7 secretion protein, HlyD family F3L01_23510 ENOG4108JGH Tetr family transcriptional regulator F3L01_23515 ENOG4105CN9 Peptidase m42 family protein F3L01_23535 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) F3L01_23540 ENOG4105C22 threonyL-tRNA synthetase F3L01_23545 ENOG4108TDW sporulation protein YtxC F3L01_23585 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase F3L01_23590 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) F3L01_23600 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) F3L01_23605 ENOG4105C2M dna polymerase I F3L01_23610 ENOG4105BZU Histidine kinase F3L01_23615 ENOG4105DPZ Two component transcriptional regulator (Winged helix family F3L01_23630 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) F3L01_23635 ENOG4108HMX isocitrate dehydrogenase (NADP) F3L01_23640 ENOG4105BZN citrate synthase F3L01_23655 ENOG4108REF Sporulation integral membrane protein ytvi F3L01_23660 ENOG4105FS0 cytoplasmic membrane protein F3L01_23685 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family F3L01_23690 ENOG4105C6K Malic enzyme F3L01_23695 ENOG4105C0B DNA polymerase III (alpha subunit) F3L01_23700 ENOG4105VV2 F3L01_23710 ENOG4105SFS phosphoesterase RecJ domain protein F3L01_23735 ENOG4105E8R UPF0173 metal-dependent hydrolase F3L01_23740 ENOG4105DC7 peptidase M24 F3L01_23775 ENOG4105Z7P Acetyltransferase (GNAT) family F3L01_23780 ENOG41082W1 Cupin 2, conserved barrel domain protein F3L01_23800 ENOG4107YZX Universal stress protein F3L01_23820 ENOG4105CH7 arginosuccinase F3L01_23840 ENOG4108JYZ YitT family F3L01_23860 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) F3L01_23870 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) F3L01_23875 ENOG4105KBJ sporulation protein ytfj F3L01_23890 ENOG4105EFZ amidohydrolase F3L01_23900 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) F3L01_23925 ENOG4105RQF LysR family Transcriptional regulator F3L01_23935 ENOG4105U5Y Transcriptional regulator F3L01_23945 ENOG4105C28 cystathionine F3L01_23965 ENOG4108IBT Inherit from COG: transposase F3L01_24015 ENOG4108UW5 maltose o-acetyltransferase F3L01_24025 ENOG4105F1V Acetoin utilization protein F3L01_24030 ENOG4105W87 Cbs domain F3L01_24035 ENOG4105DGU Histone deacetylase F3L01_24050 ENOG4105DPZ Two component transcriptional regulator (Winged helix family F3L01_24060 ENOG4107SNB ankyrin repeat protein YahD F3L01_24065 ENOG4105EP9 oxidoreductase F3L01_24085 ENOG4105ETE Transcriptional regulator (LacI family F3L01_24090 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase F3L01_24110 ENOG4105C88 aminopeptidase F3L01_24155 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase F3L01_24165 ENOG4108VDD TRNA binding domain protein F3L01_24195 ENOG4105C8F Beta-lactamase domain protein F3L01_24210 ENOG4108V15 phosphotransferase enzyme family F3L01_24215 ENOG4108IUM Glycogen debranching enzyme F3L01_24225 ENOG4107QSE Dipeptidase F3L01_24230 ENOG4105YW5 deoR family transcriptional regulator F3L01_24245 ENOG4105CBX hi0933 family F3L01_24285 ENOG4108VJ1 Transcriptional regulator (CarD family F3L01_24290 ENOG4107EXU Short-chain dehydrogenase reductase Sdr F3L01_24295 ENOG4105CSC Glucose uptake protein F3L01_24310 ENOG4108ZAF Molybdopterin F3L01_24315 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein F3L01_24320 ENOG4105CVM Molybdenum cofactor synthesis domain protein F3L01_24330 ENOG4105D06 uba thif-type nad fad binding protein F3L01_24335 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) F3L01_24360 ENOG41085GJ domain protein F3L01_24370 ENOG4105DWV Homoserine O-trans-acetylase F3L01_24380 ENOG4108B31 Spore germination protein F3L01_24405 ENOG4105C8T Leucyl-tRNA synthetase F3L01_24410 ENOG410605W Major Facilitator F3L01_24415 ENOG4107S91 Sodium hydrogen exchanger F3L01_24420 ENOG4105NCW Trka-c domain protein F3L01_24440 ENOG4105C19 ABC transporter F3L01_24460 ENOG4105N5T Radical SAM Protein F3L01_24475 ENOG4105CIG ABC transporter F3L01_24510 ENOG4105E8V Alpha Beta Hydrolase Fold protein F3L01_24515 ENOG4108Z0R Transferase F3L01_24520 ENOG4105YVM Phosphoesterase, PA-phosphatase related F3L01_24525 ENOG4105BZF Glycosyl transferase (Group 1 F3L01_24535 ENOG4105EPU Molybdenum cofactor synthesis domain protein F3L01_24545 ENOG4108MK9 spermidine N(1)-acetyltransferase F3L01_24595 ENOG4105BZU Histidine kinase F3L01_24600 ENOG4105BZU Histidine kinase F3L01_24615 ENOG4107S9D Alpha beta hydrolase F3L01_24620 ENOG4107T7U Sulfatase F3L01_24635 ENOG4105D2X ABC transporter substrate-binding protein F3L01_24645 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component F3L01_24710 ENOG4108V2W Carbonate dehydratase F3L01_24715 ENOG4105C4M (Ubiquinol oxidase) subunit I F3L01_24720 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii F3L01_24755 ENOG41087YS Phage shock protein A F3L01_24785 ENOG4105BZU Histidine kinase F3L01_24790 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L01_24815 ENOG4108UGV hypoxanthine phosphoribosyltransferase F3L01_24820 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) F3L01_24865 ENOG4105C19 ABC transporter F3L01_24880 ENOG4107ZTW SNARE associated Golgi F3L01_24895 ENOG4105C19 ABC transporter F3L01_24900 ENOG41086D8 Transcriptional regulator F3L01_24910 ENOG41082BM Transcriptional regulator, arsr family F3L01_24960 ENOG4105C6Z Gluconate F3L01_24965 ENOG4105FDP GntR family transcriptional regulator F3L01_24985 ENOG41069H0 dihydroorotase EC 3.5.2.3 F3L01_25010 ENOG4105DTQ mandelate racemase muconate lactonizing F3L01_25015 ENOG4105CEY Amp-dependent synthetase and ligase F3L01_25020 ENOG4108IPT Naphthoate synthase F3L01_25025 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) F3L01_25030 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) F3L01_25035 ENOG4105E4F Isochorismate synthase F3L01_25040 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase F3L01_25050 ENOG4105VEQ Cold shock protein F3L01_25080 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) F3L01_25085 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) F3L01_25095 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin F3L01_25200 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation F3L01_25235 ENOG4105KT7 mgtC SapB transporter F3L01_25240 ENOG4107PBV potassium channel F3L01_25260 ENOG4105WG9 Conserved Protein F3L01_25270 ENOG4105CHM Aminotransferase F3L01_25275 ENOG4108ZB6 transcriptional regulator AsnC family F3L01_25280 ENOG4105C5I Dehydrogenase F3L01_25285 ENOG4108MUZ hydrolase F3L01_25295 ENOG4105C87 Aminotransferase class I and II F3L01_25305 ENOG4105Y38 Kinase-associated protein B F3L01_25315 ENOG4107R3E Citrate transporter F3L01_25335 ENOG4105KA0 thioesterase Superfamily protein F3L01_25350 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase F3L01_25365 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) F3L01_25370 ENOG41069ER domain protein F3L01_25385 ENOG4105CEP NADH dehydrogenase F3L01_25415 ENOG4105EWC Purine nucleoside phosphorylase F3L01_25435 ENOG4108YX9 iron--sulfur cluster insertion protein erpA F3L01_25460 ENOG4108JJA ABC, transporter F3L01_25465 ENOG4105C4B ABC transporter, permease F3L01_25470 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA F3L01_25520 ENOG41083MR nifu domain-containing protein F3L01_25535 ENOG4108W5N phosphatidylglycerophosphatase a F3L01_25555 ENOG4105DAX Pfam:DUF2983 F3L01_25565 ENOG4105DYS nad(p)h dehydrogenase (quinone) F3L01_25575 ENOG4105D4U had-superfamily hydrolase, subfamily iia F3L01_25590 ENOG4105CBT Fructose-1,6-bisphosphatase F3L01_25615 ENOG4105MMD transcriptional regulator F3L01_25620 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) F3L01_25625 ENOG4107TXC Transcriptional regulator F3L01_25630 ENOG41090T1 Membrane F3L01_25655 ENOG4105FAA peptidase M23 F3L01_25660 ENOG4108YTE sporulation protein YunB F3L01_25665 ENOG4105KZD Domain of unknown function (DUF1805) F3L01_25670 ENOG4107R8B 5'-nucleotidase F3L01_25675 ENOG4105DIW FeS assembly protein SUFB F3L01_25680 ENOG4108UNV SUF system FeS assembly protein, NifU family F3L01_25685 ENOG4105C9B Cysteine desulfurase F3L01_25690 ENOG4105JRK feS assembly protein SufD F3L01_25695 ENOG4105C3K feS assembly ATPase SufC F3L01_25700 ENOG4105D01 (LipO)protein F3L01_25705 ENOG4105D01 (LipO)protein F3L01_25710 ENOG4108UMI ABC transporter, permease F3L01_25715 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) F3L01_25740 ENOG41080E8 Transcriptional regulator, Spx MgsR family F3L01_25760 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) F3L01_25785 ENOG4108W8B Beta-lactamase domain protein F3L01_25790 ENOG4105C1G acyl-Coa dehydrogenase F3L01_25795 ENOG4105CHU acetyl-coa acetyltransferase F3L01_25810 ENOG4105DZ1 carboxypeptidase F3L01_25830 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer F3L01_25840 ENOG4108SUT Major Facilitator Superfamily F3L01_25845 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) F3L01_25855 ENOG4107R7I amino acid F3L01_25875 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins F3L01_25885 ENOG4107AYK membrAne F3L01_25925 ENOG4107ZTW SNARE associated Golgi F3L01_25935 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein F3L01_25940 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L01_25945 ENOG4105BZU Histidine kinase F3L01_25955 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) F3L01_25980 ENOG4105C8Q Methyl-accepting chemotaxis F3L01_25985 ENOG4105VG1 fes assembly suf system protein F3L01_25990 ENOG4105D4Y metalloprotease F3L01_26010 ENOG4107T5V SNARE associated Golgi F3L01_26015 ENOG4107S91 Sodium hydrogen exchanger F3L01_26020 ENOG4105NCW Trka-c domain protein F3L01_26035 ENOG4108RMU ferritin dps family protein F3L01_26055 ENOG4108URH decarboxylase F3L01_26065 ENOG41090A1 ferritin F3L01_26075 ENOG4105D9N nucleoside F3L01_26080 ENOG4105D9N nucleoside F3L01_26095 ENOG4108RYK Nad-dependent epimerase dehydratase F3L01_26110 ENOG4105CV8 reductase F3L01_26115 ENOG4105F27 Major Facilitator F3L01_26120 ENOG4105KVH Transcriptional regulator F3L01_26135 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) F3L01_26140 ENOG4105D4A Cell wall formation (By similarity) F3L01_26160 ENOG4105WMR Protein CrcB homolog F3L01_26165 ENOG4105WMR Protein CrcB homolog F3L01_26175 ENOG4108MK9 spermidine N(1)-acetyltransferase F3L01_26225 ENOG4108IPW abc transporter atp-binding protein F3L01_26230 ENOG4105CM4 permease protein F3L01_26245 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L01_26250 ENOG4105EWM Histidine kinase F3L01_26255 ENOG4105CJZ response regulator F3L01_26260 ENOG4105C19 ABC transporter F3L01_26285 ENOG4105C19 ABC transporter F3L01_26325 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) F3L01_26335 ENOG4105XZU Preprotein translocase, subunit SecG F3L01_26340 ENOG41067MG lrgb family F3L01_26390 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F3L01_26630 ENOG4105VTR Integrase F3L01_26650 ENOG41090VF Stage v sporulation protein ac F3L01_26655 ENOG4105CZ3 stage V sporulation protein ad F3L01_26670 ENOG4108QY0 Membrane F3L01_26680 ENOG4105KRI phosphocarrier protein (HPr F3L01_26690 ENOG4105CHW UPF0052 protein F3L01_26700 ENOG4108Z4K mutator MutT protein F3L01_26710 ENOG4105C3M thioredoxin reductase F3L01_26720 ENOG4108S4C acetyltransferase F3L01_26730 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) F3L01_26740 ENOG41086DT Membrane protein of unknown function F3L01_26745 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) F3L01_26750 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) F3L01_26765 ENOG4107TXC Transcriptional regulator F3L01_26785 ENOG4105DUM transcriptional regulator, lysR family F3L01_26795 ENOG4108WS4 fmn reductase F3L01_26810 ENOG4105BZ1 (ABC) transporter F3L01_26820 ENOG4105CN1 protease F3L01_26825 ENOG4105CRP Part of the ABC transporter FtsEX involved in F3L01_26830 ENOG4105CAK Cell division ATP-binding protein ftsE F3L01_26860 ENOG4108RDQ ABC transporter F3L01_26890 ENOG4105MS2 ribosomal subunit Interface protein F3L01_26895 ENOG4105VEQ Cold shock protein F3L01_26900 ENOG41081UC Inherit from COG: Competence protein F3L01_26910 ENOG4105K4H Nlp p60 protein F3L01_26915 ENOG4105KVH Transcriptional regulator F3L01_26925 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein F3L01_26930 ENOG4108KGH TRANSCRIPTIONal F3L01_26935 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase F3L01_26940 ENOG4105C6Y Udp-glucose 6-dehydrogenase F3L01_26945 ENOG4105ESV Glycosyl transferase, family 4 F3L01_26955 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family F3L01_26975 ENOG4105F8D glycoside hydrolase family 4 F3L01_26980 ENOG4105VCP PTS System F3L01_26985 ENOG4105CK1 PTS System F3L01_26995 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) F3L01_27000 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) F3L01_27005 ENOG4105VCP PTS System F3L01_27015 ENOG4105VZJ PTS System F3L01_27035 ENOG4105ECB domain protein F3L01_27040 ENOG4107RSM transcriptional regulator F3L01_27065 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) F3L01_27070 ENOG4105DAA L-lactate F3L01_27080 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) F3L01_27095 ENOG4105E0M Sulfatase F3L01_27120 ENOG4107R8N Glycosyl transferase, family 2 F3L01_27125 ENOG4105C94 Transporter F3L01_27135 ENOG41069ER domain protein F3L01_27160 ENOG4105KBK Zinc finger, swim domain protein F3L01_27165 ENOG4105C0D helicase F3L01_27195 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) F3L01_27210 ENOG4107RBB ABC transporter, permease F3L01_27215 ENOG4105C19 ABC transporter F3L01_27225 ENOG4105CXY transporter F3L01_27240 ENOG4105BZU Histidine kinase F3L01_27245 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L01_27250 ENOG4105DG6 mannose-6-phosphate isomerase F3L01_27255 ENOG4105DM4 PTS System F3L01_27275 ENOG4108KGH TRANSCRIPTIONal F3L01_27280 ENOG4105DG6 mannose-6-phosphate isomerase F3L01_27285 ENOG4105CJT Mannose-1-phosphate guanylyltransferase F3L01_27295 ENOG4108TJN glycosyl transferase group 1 F3L01_27300 ENOG4105C6Y Udp-glucose 6-dehydrogenase F3L01_27330 ENOG4105D3Q Sugar transferase F3L01_27335 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase F3L01_27340 ENOG4108RB3 Capsular polysaccharide biosynthesis protein F3L01_27345 ENOG4107YJ4 chain length determinant protein F3L01_27350 ENOG4105HTX biosynthesis protein F3L01_27355 ENOG4107YJ4 chain length determinant protein F3L01_27370 ENOG4105MT0 Sporulation transcriptional regulator spoiiid F3L01_27380 ENOG4105FRN stage II sporulation protein F3L01_27395 ENOG4105DY9 regulatoR F3L01_27425 ENOG4106778 Protein of unknown function (DUF1146) F3L01_27430 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F3L01_27435 ENOG4105C8S subunit m F3L01_27440 ENOG4105D65 subunit l F3L01_27465 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) F3L01_27470 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain F3L01_27480 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain F3L01_27485 ENOG4105BZU Histidine kinase F3L01_27535 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) F3L01_27540 ENOG41062M3 atp synthase F3L01_27560 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) F3L01_27565 ENOG4108UIC UPF0340 protein F3L01_27570 ENOG4108YZG isomerase F3L01_27585 ENOG4108VGI doxx family F3L01_27590 ENOG4107XC4 flavin reductase domain protein, FMN-binding F3L01_27605 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) F3L01_27615 ENOG4108ZXQ stage ii sporulation protein r F3L01_27620 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) F3L01_27625 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) F3L01_27630 ENOG4107104 thymidine kinase F3L01_27645 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) F3L01_27655 ENOG4105CBT Fructose-1,6-bisphosphatase F3L01_27660 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) F3L01_27680 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) F3L01_27695 ENOG4105C1G acyl-Coa dehydrogenase F3L01_27700 ENOG4105C1G acyl-Coa dehydrogenase F3L01_27705 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase F3L01_27715 ENOG4105DF6 Fe-S oxidoreductase F3L01_27730 ENOG4105BZU Histidine kinase F3L01_27745 ENOG4105D4Y metalloprotease F3L01_27755 ENOG4105BZU Histidine kinase F3L01_27760 ENOG4105KCT ABC transporter F3L01_27765 ENOG4108M15 ABC transporter F3L01_27770 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) F3L01_27780 ENOG4105IIU Aminopeptidase F3L01_27800 ENOG4105DU6 RNA polymerase F3L01_27810 ENOG410684U Domain of unknown function (DUF1934) F3L01_27830 ENOG4105CYW agmatinase F3L01_27840 ENOG4105DXB Major Facilitator superfamily F3L01_27845 ENOG4107SWG transcriptional regulator MERR family F3L01_27850 ENOG4108QXE glycerophosphoryl diester phosphodiesterase F3L01_27855 ENOG4105BZ4 penicillin-binding protein F3L01_27860 ENOG4108XFG YwhD family F3L01_27865 ENOG4108Z4T Peptidase M50 F3L01_27870 ENOG41069HH 4-oxalocrotonate tautomerase F3L01_27875 ENOG4105DCI Phosphohydrolase F3L01_27880 ENOG4108MES Periplasmic binding protein F3L01_27885 ENOG4105E0A ABC, transporter F3L01_27890 ENOG4105EHG Permease protein F3L01_27895 ENOG4105DQ5 transport system permease protein F3L01_27905 ENOG4108VCI transcription factor, rsfa family F3L01_27915 ENOG4108IJ2 phosphate acetyltransferase F3L01_27930 ENOG4108VKI Cell wall hydrolase F3L01_27950 ENOG4107SVH Potassium channel protein F3L01_27960 ENOG410667J hydrolase F3L01_27965 ENOG4105VCH membrane F3L01_27975 ENOG4108TU7 Inherit from COG: (ABC) transporter F3L01_27980 ENOG4105CJ1 ABC, transporter F3L01_27985 ENOG41090WU lipolytic protein G-D-S-L family F3L01_28000 ENOG4105D6E homoserine dehydrogenase F3L01_28005 ENOG4105CVG Homoserine O-transsuccinylase F3L01_28025 ENOG4108Y4K DNA-binding transcriptional activator F3L01_28035 ENOG4105WH1 Two component transcriptional regulator luxr family F3L01_28040 ENOG4105BZU Histidine kinase F3L01_28045 ENOG4105DWF phosphomethylpyrimidine kinase F3L01_28050 ENOG4105BZU Histidine kinase F3L01_28055 ENOG4105VCD cytoplasmic protein F3L01_28060 ENOG4105D22 carbon starvation protein F3L01_28065 ENOG4105DY9 regulatoR F3L01_28070 ENOG41079KZ Major Facilitator Superfamily F3L01_28085 ENOG4105CG5 Glycosyl transferase (Group 1 F3L01_28095 ENOG4105EN6 Membrane F3L01_28100 ENOG4106YBV Methyl-accepting chemotaxis F3L01_28110 ENOG4108S4H thioesterase Superfamily protein F3L01_28115 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) F3L01_28130 ENOG4105K64 Glycosyl transferase, family 2 F3L01_28145 ENOG4105CKK Glycosyl transferase, family 2 F3L01_28150 ENOG4105C5H ABC transporter F3L01_28155 ENOG41067SE Tetr family transcriptional regulator F3L01_28165 ENOG4105E0X reductase F3L01_28170 ENOG4106F5Q Membrane F3L01_28185 ENOG4108NEV two component transcriptional regulator, LytTR family F3L01_28195 ENOG4107RGD Major Facilitator superfamily F3L01_28215 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) F3L01_28225 ENOG4105IW1 AmiS UreI transporter F3L01_28235 ENOG4105CMR udp-glucose 4-epimerase F3L01_28240 ENOG4108UT2 hemolysin iii F3L01_28250 ENOG4105C1J atp-dependent rna helicase F3L01_28255 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) F3L01_28260 ENOG4105DPN Oligoendopeptidase f F3L01_28320 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) F3L01_28330 ENOG4105C0H protease F3L01_28335 ENOG4105Q2H domain protein F3L01_28350 ENOG4105BZU Histidine kinase F3L01_28355 ENOG4105CK6 Two component transcriptional regulator (Winged helix family F3L01_28380 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis F3L01_28385 ENOG4105CDU Replicative dna helicase F3L01_28395 ENOG4105BZR domain protein F3L01_28400 ENOG4108XMW Membrane F3L01_28410 ENOG4108UUM single-stranded DNA-binding protein F3L01_28420 ENOG4105C3G gtp-binding protein F3L01_28425 ENOG4105VDK protein, conserved in bacteria F3L01_28430 ENOG4105D8X mechanosensitive ion channel F3L01_28435 ENOG4108ZDA Sporulation protein YyaC F3L01_28440 ENOG4105FA0 parb-like partition protein F3L01_28445 ENOG4107QJE Chromosome Partitioning Protein F3L01_28460 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) F3L01_28465 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) F3L01_28475 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins F3L01_28585 ENOG4106A7E Transcriptional regulator F3L01_28590 ENOG4108VB1 regulatoR F3L01_28685 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) F3L01_28695 ENOG4105D9M gamma-glutamylcysteine synthetase F3L01_28705 ENOG4105C4W S-formylglutathione hydrolase F3L01_28715 ENOG4105KVH Transcriptional regulator F3L01_28735 ENOG4105E1K spore germination protein F3L01_28740 ENOG4108B31 Spore germination protein F3L01_28760 ENOG4108QY0 Membrane F3L01_28775 ENOG4105CZ3 stage V sporulation protein ad F3L01_28780 ENOG41090VF Stage v sporulation protein ac F3L01_28795 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) F3L01_28865 ENOG4105K59 histidine triad (HIT) protein F3L01_28890 ENOG41086D8 Transcriptional regulator F3L01_28935 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) F3L01_28940 ENOG4105WFK nuclease F3L01_28945 ENOG4105EKQ RNA-directed DNA polymerase F3L01_29205 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) F3L01_29255 ENOG4105EKQ RNA-directed DNA polymerase F3L01_29320 ENOG4108Q5U germination protein, ger(x)c family