locus-tag class description CJ306_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CJ306_00015 ENOG410848D S4 domain protein YaaA CJ306_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CJ306_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CJ306_00100 ENOG4105ZMH deoxynucleoside kinase CJ306_00110 ENOG4105GTG Isochorismatase CJ306_00120 ENOG4108Z6B deaminase CJ306_00130 ENOG4105C6E dna polymerase iii CJ306_00150 ENOG41067KS pro-sigma K processing CJ306_00185 ENOG4105CXN decarboxylase CJ306_00195 ENOG4105FA2 dna polymerase iii CJ306_00200 ENOG4105MA4 psp1 domain protein CJ306_00210 ENOG41060K3 Methyltransferase CJ306_00220 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) CJ306_00225 ENOG4105KRN Transcriptional regulator, abrb family CJ306_00230 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) CJ306_00235 ENOG4105F8V Hydrolase, tatD family CJ306_00240 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) CJ306_00250 ENOG4105XFA sporulation peptidase YabG CJ306_00255 ENOG4105W42 Veg protein CJ306_00270 ENOG4105DFT pur operon repressor CJ306_00275 ENOG4105KME endoribonuclease L-psp CJ306_00290 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CJ306_00295 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) CJ306_00305 ENOG4108JA2 transcriptioN-repair coupling factor CJ306_00310 ENOG4108M14 stage v sporulation protein t CJ306_00320 ENOG4108IY2 MazG family CJ306_00325 ENOG41082I2 s4 domain protein CJ306_00330 ENOG4105VYY sporulation protein yabp CJ306_00345 ENOG41060GV RNA binding s1 domain protein CJ306_00365 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) CJ306_00370 ENOG4108UGV hypoxanthine phosphoribosyltransferase CJ306_00375 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CJ306_00390 ENOG4105C6T cysteine synthase CJ306_00395 ENOG4105CRQ synthase (Component I) CJ306_00400 ENOG4105DDQ anthranilate synthase CJ306_00405 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 CJ306_00410 ENOG4105EEI dihydropteroate synthase CJ306_00415 ENOG4105KRF dihydroneopterin aldolase CJ306_00420 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CJ306_00430 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CJ306_00520 ENOG4108Z0C Uvrb UvrC protein CJ306_00535 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CJ306_00540 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) CJ306_00545 ENOG4105CTP PilT protein domain protein CJ306_00550 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) CJ306_00565 ENOG4105D7W serine acetyltransferase CJ306_00580 ENOG4105C2N RNA methyltransferase TrmH family group 3 CJ306_00585 ENOG4105M0M Tetracycline resistance protein CJ306_00590 ENOG4105QIV RNA polymerase CJ306_00605 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) CJ306_00630 ENOG4107Y49 methyltransferase CJ306_00645 ENOG4105XPM ribosomal protein CJ306_00755 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) CJ306_00780 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CJ306_00790 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CJ306_00800 ENOG41067V7 50S ribosomal protein L36 CJ306_00825 ENOG4108JJB ABC transporter CJ306_00830 ENOG4108JJB ABC transporter CJ306_00835 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) CJ306_00840 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) CJ306_00865 ENOG4105D1F ATP-binding protein CJ306_00880 ENOG4108NMV polysaccharide deacetylase CJ306_00960 ENOG4105C8B TIGR00159 family CJ306_00965 ENOG4107U5W ybbr family CJ306_00980 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CJ306_01005 ENOG4108PSK reductase CJ306_01010 ENOG4108UMI ABC transporter, permease CJ306_01020 ENOG4105D01 (LipO)protein CJ306_01025 ENOG4105CB2 alcohol dehydrogenase CJ306_01035 ENOG4105IQ5 FAD linked oxidase domain protein CJ306_01050 ENOG4105C2C drug resistance transporter, Bcr CflA CJ306_01065 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CJ306_01070 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CJ306_01075 ENOG4105C3U ABC transporter CJ306_01080 ENOG4108JQ7 (ABC) transporter CJ306_01110 ENOG4108J59 Extracellular solute-binding protein, family 5 CJ306_01115 ENOG4108J59 Extracellular solute-binding protein, family 5 CJ306_01135 ENOG4105E0C molybdate abc transporter CJ306_01140 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CJ306_01145 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family CJ306_01160 ENOG4105EGI Transcriptional regulator CJ306_01180 ENOG4105F6E Acyl-transferase CJ306_01205 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) CJ306_01225 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) CJ306_01250 ENOG4105C5H ABC transporter CJ306_01265 ENOG4105DEF Extracellular solute-binding protein, family 5 CJ306_01275 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CJ306_01280 ENOG4105C3U ABC transporter CJ306_01285 ENOG4108JQ7 (ABC) transporter CJ306_01290 ENOG410667J hydrolase CJ306_01325 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase CJ306_01330 ENOG4105ERH Fumarylacetoacetate hydrolase CJ306_01345 ENOG4105CUB amino acid CJ306_01350 ENOG4108SC4 )-transporter CJ306_01355 ENOG4105CPF Cell wall formation (By similarity) CJ306_01360 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) CJ306_01385 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein CJ306_01390 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CJ306_01400 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) CJ306_01505 ENOG4105K8N protein family UPF0079, ATPase CJ306_01510 ENOG41072GX Peptidase M22 Glycoprotease CJ306_01515 ENOG410801F ribosomal-protein-alanine acetyltransferase CJ306_01520 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CJ306_01525 ENOG4105C5H ABC transporter CJ306_01540 ENOG4108TYN CAAX amino terminal protease family protein CJ306_01555 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CJ306_01560 ENOG4105C7N Xanthine uracil vitamin C permease CJ306_01570 ENOG4105BZU Histidine kinase CJ306_01600 ENOG4107ZXU DSBA oxidoreductase CJ306_01650 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CJ306_01680 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CJ306_01690 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) CJ306_01720 ENOG4105SX7 Transporter CJ306_01750 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CJ306_01755 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit CJ306_01760 ENOG4105C83 adenylosuccinate lyase CJ306_01770 ENOG4105VR9 phosphoribosylformylglycinamidine synthase CJ306_01795 ENOG4108V3E phosphoribosylglycinamide formyltransferase CJ306_01800 ENOG4105DC1 bifunctional purine biosynthesis protein purh CJ306_01805 ENOG4105C12 Phosphoribosylglycinamide synthetase CJ306_01835 ENOG4105C4R Atp-dependent dna helicase CJ306_01840 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) CJ306_01860 ENOG4108W2Y isochorismatase CJ306_01865 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CJ306_01870 ENOG4108UMI ABC transporter, permease CJ306_01875 ENOG4105D01 (LipO)protein CJ306_01895 ENOG410834F Transcriptional regulator CJ306_01900 ENOG4107I77 yiaA/B two helix domain CJ306_01920 ENOG4105CBD Diacylglycerol kinase CJ306_01930 ENOG4108JPW Aminotransferase CJ306_01940 ENOG4105C26 Dehydrogenase CJ306_01945 ENOG4105KPY Small multidrug resistance protein CJ306_01970 ENOG4105D9N nucleoside CJ306_01975 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CJ306_01985 ENOG4108W15 Protein of unknown function (DUF1456) CJ306_02000 ENOG4105DTQ mandelate racemase muconate lactonizing CJ306_02010 ENOG4105DFD Na H antiporter CJ306_02035 ENOG4105D3R alkyl hydroperoxide reductase CJ306_02040 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) CJ306_02045 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) CJ306_02050 ENOG4107W7X Aldolase CJ306_02055 ENOG4105EHG Permease protein CJ306_02060 ENOG4105DQ5 transport system permease protein CJ306_02065 ENOG4108V5C ABC transporter CJ306_02075 ENOG4105CAY ferredoxin--nadp reductase CJ306_02095 ENOG4106UIA CJ306_02100 ENOG4106UIA CJ306_02115 ENOG4105BZU Histidine kinase CJ306_02135 ENOG410756H nucleotidyltransferase CJ306_02140 ENOG4105D2S major facilitator superfamily CJ306_02155 ENOG4105E5Q amino acid AbC transporter CJ306_02160 ENOG4105EAB amino acid AbC transporter CJ306_02170 ENOG4105C8Q Methyl-accepting chemotaxis CJ306_02185 ENOG4105DBV ornithine carbamoyltransferase CJ306_02195 ENOG4105C5B carbamate kinase CJ306_02200 ENOG4108W63 CRP FNR family transcriptional regulator CJ306_02210 ENOG4105DNP FAD linked oxidase domain protein CJ306_02220 ENOG4105CI1 PTS System CJ306_02275 ENOG4105C9U ATP-dependent DNA helicase RecQ CJ306_02290 ENOG4105CNF WD-40 repeat protein CJ306_02310 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter CJ306_02330 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component CJ306_02335 ENOG4105D2X ABC transporter substrate-binding protein CJ306_02380 ENOG41062JF Transcriptional regulator CJ306_02395 ENOG4105DEU major facilitator superfamily CJ306_02410 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) CJ306_02425 ENOG4108N0M stress protein CJ306_02430 ENOG4106FN3 tellurium resistance protein CJ306_02435 ENOG4106FN3 tellurium resistance protein CJ306_02440 ENOG4107TS3 membrane protein, TerC CJ306_02445 ENOG4108TTB tellurium resistance protein CJ306_02460 ENOG41068PA UPF0435 protein CJ306_02465 ENOG4105KJF protein tyrosine phosphatase CJ306_02475 ENOG4107U9T Pfam:Ribonuclease_BN CJ306_02485 ENOG4105C59 p-type ATPase CJ306_02490 ENOG4108IPJ Membrane CJ306_02510 ENOG4107ZTW SNARE associated Golgi CJ306_02525 ENOG410606W general stress protein CJ306_02530 ENOG4105UPD Calcium Proton CJ306_02565 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CJ306_02570 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) CJ306_02580 ENOG4108JUB Transcriptional regulator CJ306_02590 ENOG4108IQI permease CJ306_02635 ENOG4108A04 Beta-lactamase CJ306_02650 ENOG4105CKK Glycosyl transferase, family 2 CJ306_02655 ENOG4107QQG Dehydrogenase CJ306_02660 ENOG4105C3I Nad-dependent epimerase dehydratase CJ306_02680 ENOG4105F1A Pyruvate formate-lyase CJ306_02685 ENOG4108QBV Monogalactosyldiacylglycerol synthase CJ306_02700 ENOG4105CI2 imidazolone-5-propionate hydrolase CJ306_02705 ENOG4105ECP epimerase CJ306_02735 ENOG41067AE Membrane-bound metal-dependent hydrolase CJ306_02740 ENOG4105CEN a g-specific adenine glycosylase CJ306_02745 ENOG4106BXE CJ306_02765 ENOG4105BZ1 (ABC) transporter CJ306_02770 ENOG4107NBY Membrane CJ306_02775 ENOG4105CBC glutamate synthase CJ306_02785 ENOG4108IUW ABC transporter CJ306_02805 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CJ306_02810 ENOG4105G5W regulator Fur family CJ306_02925 ENOG4105CDY transcriptional regulatory protein CJ306_02935 ENOG4108JQC penicillin-binding protein 1A CJ306_02940 ENOG4108R9S DSBA oxidoreductase CJ306_02950 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) CJ306_02960 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CJ306_02965 ENOG4105BZU Histidine kinase CJ306_02975 ENOG4105CYN Serine protein kinase CJ306_02985 ENOG4106AKX UPF0229 protein CJ306_02995 ENOG4105C94 Transporter CJ306_03010 ENOG4105DZ6 Band 7 protein CJ306_03020 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism CJ306_03025 ENOG4108V9W transcriptional regulatory protein CJ306_03030 ENOG4105D4T Citrate transporter CJ306_03050 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator CJ306_03055 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CJ306_03060 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component CJ306_03065 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component CJ306_03070 ENOG4105BZ7 extracellular solute-binding protein family 1 CJ306_03075 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) CJ306_03080 ENOG4108STX response regulator CJ306_03085 ENOG4105US7 Histidine kinase CJ306_03110 ENOG4108MRH transcriptional regulatory protein CJ306_03120 ENOG4105C6K Malic enzyme CJ306_03130 ENOG4108UZ3 Transporter CJ306_03135 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CJ306_03145 ENOG4105BZU Histidine kinase CJ306_03150 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CJ306_03160 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) CJ306_03165 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CJ306_03170 ENOG4108JB9 formate dehydrogenase CJ306_03190 ENOG4105CUB amino acid CJ306_03205 ENOG4105C59 p-type ATPase CJ306_03210 ENOG4105DAP Nicotinate phosphoribosyltransferase CJ306_03245 ENOG41073R8 VanW family CJ306_03250 ENOG4108KGH TRANSCRIPTIONal CJ306_03255 ENOG4105D9N nucleoside CJ306_03260 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase CJ306_03265 ENOG4105C37 (CBS) domain CJ306_03270 ENOG4108IJ0 Aspartate ammonia-lyase CJ306_03275 ENOG4105DAA L-lactate CJ306_03290 ENOG4105DUX Transporter CJ306_03295 ENOG4108MES Periplasmic binding protein CJ306_03300 ENOG4105DQ5 transport system permease protein CJ306_03305 ENOG4108IHU transport system permease protein CJ306_03310 ENOG4105E0A ABC, transporter CJ306_03320 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CJ306_03325 ENOG4105EXW epimerase dehydratase CJ306_03335 ENOG4107T89 von Willebrand factor, type A CJ306_03340 ENOG4105GMT ATPase associated with various cellular activities aaa_5 CJ306_03345 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CJ306_03360 ENOG4105BZU Histidine kinase CJ306_03365 ENOG4105D5Q Arginine ornithine antiporter CJ306_03370 ENOG4107414 GntR family transcriptional regulator CJ306_03375 ENOG4105C5Y PTS System CJ306_03380 ENOG4105CG3 alpha amylase, catalytic region CJ306_03395 ENOG4105E1K spore germination protein CJ306_03405 ENOG4105CRN Aminoglycoside phosphotransferase CJ306_03410 ENOG4105BZG amino acid carrier protein CJ306_03420 ENOG4105CDA abc transporter atp-binding protein CJ306_03425 ENOG4105CT1 (ABC) transporter CJ306_03430 ENOG4105EAD ABC transporter CJ306_03435 ENOG4105DRP amino acid AbC transporter CJ306_03440 ENOG4108IQI permease CJ306_03455 ENOG4105GFR rna polymerase sigma factor CJ306_03465 ENOG4105D29 Helix-turn-helix type 11 domain protein CJ306_03470 ENOG4105NAE bifunctional deaminase-reductase domain protein CJ306_03475 ENOG4105BZU Histidine kinase CJ306_03500 ENOG4105CHH sulfate transporter CJ306_03505 ENOG41068KF Universal stress protein CJ306_03515 ENOG4105CXY transporter CJ306_03520 ENOG41067TZ transcriptional regulator, MarR family CJ306_03525 ENOG4105C0R drug resistance transporter emrb qaca subfamily CJ306_03530 ENOG4105ETE Transcriptional regulator (LacI family CJ306_03535 ENOG4108RVA ribokinase CJ306_03540 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) CJ306_03545 ENOG4105C2J ABC transporter CJ306_03550 ENOG4105CNN ABC, transporter CJ306_03555 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CJ306_03560 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CJ306_03595 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) CJ306_03625 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CJ306_03630 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer CJ306_03635 ENOG41069ER domain protein CJ306_03640 ENOG4105VZ8 Transcriptional regulator CJ306_03645 ENOG4107D63 CJ306_03660 ENOG4105DUX Transporter CJ306_03680 ENOG4105C85 amino acid CJ306_03685 ENOG4105C7N Xanthine uracil vitamin C permease CJ306_03695 ENOG4105D7V transposase CJ306_03710 ENOG4105MA6 gCN5-related N-acetyltransferase CJ306_03735 ENOG4105BZ9 Cytochrome C oxidase, subunit I CJ306_03740 ENOG4105E2S oxidase) subunit II CJ306_03760 ENOG4106CAD Protein of unknown function (DUF3311) CJ306_03765 ENOG4105E1V na solute symporter CJ306_03780 ENOG4108NHD germination protein CJ306_03790 ENOG4105CE1 Ferrous iron transport protein b CJ306_03795 ENOG4105CE1 Ferrous iron transport protein b CJ306_03800 ENOG4105CE1 Ferrous iron transport protein b CJ306_03805 ENOG4105CVA phosphate CJ306_03810 ENOG4105C8U phosphate abc transporter CJ306_03815 ENOG4105E2Z phosphate ABC transporter (Permease CJ306_03940 ENOG41080XQ Signal transduction protein with cbs domains CJ306_03965 ENOG4105ETU transcriptional activator (TenA CJ306_03975 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component CJ306_03985 ENOG4108VEU Thiamine monophosphate synthase CJ306_03990 ENOG41080HI glycine oxidase CJ306_04005 ENOG4105D06 uba thif-type nad fad binding protein CJ306_04010 ENOG4105DWF phosphomethylpyrimidine kinase CJ306_04050 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) CJ306_04065 ENOG4108INS Transcriptional regulator CJ306_04090 ENOG4105C19 ABC transporter CJ306_04105 ENOG4105CNN ABC, transporter CJ306_04120 ENOG4105C7N Xanthine uracil vitamin C permease CJ306_04130 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein CJ306_04150 ENOG4105C5Y PTS System CJ306_04165 ENOG4105K63 Thioredoxin CJ306_04185 ENOG4108B31 Spore germination protein CJ306_04205 ENOG4107Y03 Nitroreductase CJ306_04210 ENOG4105ED1 spovr family CJ306_04230 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase CJ306_04235 ENOG4105XTG Pfam:DUF156 CJ306_04240 ENOG4105VFE sira family CJ306_04245 ENOG4107TPS domain protein CJ306_04250 ENOG4105VFE sira family CJ306_04260 ENOG41085GJ domain protein CJ306_04265 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase CJ306_04270 ENOG41087NI Sulfite exporter TauE/SafE CJ306_04280 ENOG4108KGH TRANSCRIPTIONal CJ306_04310 ENOG4105EMD TRANSCRIPTIONal CJ306_04315 ENOG4105VCP PTS System CJ306_04320 ENOG4105VZJ PTS System CJ306_04340 ENOG41069ER domain protein CJ306_04345 ENOG4107RBB ABC transporter, permease CJ306_04350 ENOG4105C19 ABC transporter CJ306_04380 ENOG4105WEF catalase CJ306_04415 ENOG4107T5V SNARE associated Golgi CJ306_04450 ENOG4105CUB amino acid CJ306_04455 ENOG4107RWR Sodium hydrogen exchanger CJ306_04465 ENOG4106KNT transcriptional regulator CJ306_04470 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate CJ306_04505 ENOG4108YXU transcriptional regulator AsnC family CJ306_04510 ENOG4105CH7 arginosuccinase CJ306_04515 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CJ306_04525 ENOG4105KPY Small multidrug resistance protein CJ306_04560 ENOG4105NF4 modulator of drug activity CJ306_04565 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) CJ306_04570 ENOG4105E5W Transporter CJ306_04580 ENOG4107RKG DJ-1/PfpI family CJ306_04585 ENOG4105CH6 catalase CJ306_04595 ENOG4105D5Q Arginine ornithine antiporter CJ306_04600 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) CJ306_04610 ENOG4105C26 Dehydrogenase CJ306_04630 ENOG4105BZ1 (ABC) transporter CJ306_04635 ENOG4105BZ1 (ABC) transporter CJ306_04650 ENOG4105DRP amino acid AbC transporter CJ306_04655 ENOG4105CDA abc transporter atp-binding protein CJ306_04670 ENOG410839P CJ306_04705 ENOG4107FQX Alpha-acetolactate decarboxylase CJ306_04710 ENOG4108VX5 3-methyladenine DNA glycosylase CJ306_04725 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CJ306_04730 ENOG4105D4P Coproporphyrinogen iii oxidase CJ306_04740 ENOG4105CEY Amp-dependent synthetase and ligase CJ306_04755 ENOG4105CHH sulfate transporter CJ306_04780 ENOG4105CGU Enoyl-CoA hydratase CJ306_04800 ENOG4105DER m42 family CJ306_04820 ENOG4105CTU Proline racemase CJ306_04825 ENOG4105CIF Ornithine Cyclodeaminase CJ306_04840 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CJ306_04845 ENOG4105C3U ABC transporter CJ306_04850 ENOG4108JQ7 (ABC) transporter CJ306_04905 ENOG4108IBT Inherit from COG: transposase CJ306_05025 ENOG4105CSH Transporter CJ306_05035 ENOG4108MRH transcriptional regulatory protein CJ306_05045 ENOG4105M6F mutator MutT protein CJ306_05060 ENOG4105CDU Replicative dna helicase CJ306_05085 ENOG4105C0R drug resistance transporter emrb qaca subfamily CJ306_05100 ENOG4105D9U N-acetyltransferase CJ306_05125 ENOG4105F6J Alpha beta hydrolase fold CJ306_05175 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase CJ306_05190 ENOG4105CMT Dihydroxyacetone kinase CJ306_05200 ENOG4105CMT Dihydroxyacetone kinase CJ306_05210 ENOG410847I Transcriptional regulator, BadM Rrf2 family CJ306_05260 ENOG41069ER domain protein CJ306_05340 ENOG4105WN5 stage II sporulation protein CJ306_05350 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CJ306_05360 ENOG4108MJI response regulator CJ306_05365 ENOG4105BZU Histidine kinase CJ306_05370 ENOG4105BZU Histidine kinase CJ306_05395 ENOG4105K8R UPF0145 protein CJ306_05415 ENOG4107QHE Choloylglycine hydrolase CJ306_05435 ENOG4107VRP DNA repair exonuclease CJ306_05440 ENOG4106D4I domain protein CJ306_05470 ENOG4108MUZ hydrolase CJ306_05495 ENOG4105F0F Oxalate decarboxylase CJ306_05505 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator CJ306_05520 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CJ306_05540 ENOG4105EMN RNA polymerase sigma factor CJ306_05565 ENOG4105EEM helicase CJ306_05575 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CJ306_05605 ENOG4105K59 histidine triad (HIT) protein CJ306_05645 ENOG410905X membrane-flanked domain protein CJ306_05650 ENOG4105CKV Membrane CJ306_05685 ENOG410905X membrane-flanked domain protein CJ306_05690 ENOG4105CKV Membrane CJ306_05700 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation CJ306_05705 ENOG4105BZ4 penicillin-binding protein CJ306_05715 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CJ306_05720 ENOG4105C1Q protoporphyrinogen oxidase CJ306_05745 ENOG4105NA0 Transcriptional regulator CJ306_05760 ENOG4105ECB domain protein CJ306_05780 ENOG4108MK9 spermidine N(1)-acetyltransferase CJ306_05790 ENOG4105D29 Helix-turn-helix type 11 domain protein CJ306_05800 ENOG4106AXD CJ306_05805 ENOG4108RQ5 Beta-lactamase domain-containing protein CJ306_05810 ENOG4105DF9 Lipoate-protein, ligase CJ306_05820 ENOG4105CEY Amp-dependent synthetase and ligase CJ306_05955 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) CJ306_05960 ENOG4107RN3 metallophosphoesterase CJ306_05965 ENOG4107TVP HD domain protein CJ306_05970 ENOG4108AEY RNA polymerase sigma factor CJ306_05975 ENOG41086D8 Transcriptional regulator CJ306_05990 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CJ306_06010 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 CJ306_06015 ENOG4105C8Q Methyl-accepting chemotaxis CJ306_06020 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) CJ306_06030 ENOG4107QP3 malate synthase g CJ306_06060 ENOG4105VEQ Cold shock protein CJ306_06095 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation CJ306_06140 ENOG4105ERH Fumarylacetoacetate hydrolase CJ306_06150 ENOG4105C8Y Acetylornithine aminotransferase CJ306_06155 ENOG4106BKT UPF0344 protein CJ306_06165 ENOG4105CAQ asparagine synthetase CJ306_06170 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CJ306_06175 ENOG4105CH6 catalase CJ306_06180 ENOG4105BZU Histidine kinase CJ306_06200 ENOG4108VPT UPF0234 protein CJ306_06205 ENOG4105QNR S1 RNA binding domain protein CJ306_06210 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CJ306_06220 ENOG4107AYK membrAne CJ306_06225 ENOG41073B9 CJ306_06235 ENOG4108KP7 hydrolase CJ306_06250 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CJ306_06275 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CJ306_06280 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CJ306_06300 ENOG4105C31 Tryptophanyl-tRNA synthetase CJ306_06320 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CJ306_06325 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CJ306_06335 ENOG4108JQ7 (ABC) transporter CJ306_06340 ENOG4105UQX Mate efflux family protein CJ306_06365 ENOG4108ZCF integral membrane protein CJ306_06375 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CJ306_06385 ENOG4105DPN Oligoendopeptidase f CJ306_06400 ENOG4108Z18 K06886 hemoglobin CJ306_06405 ENOG4105MIX Adenylate cyclase CJ306_06410 ENOG4106EFP UPF0738 protein CJ306_06420 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CJ306_06425 ENOG4105EMS pseudouridine synthase CJ306_06445 ENOG4105K64 Glycosyl transferase, family 2 CJ306_06465 ENOG4107TVC Glycosyl transferase, family 2 CJ306_06485 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) CJ306_06490 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase CJ306_06500 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase CJ306_06550 ENOG4108ZMI UPF0477 protein CJ306_06575 ENOG4105CK7 Sodium proline symporter CJ306_06585 ENOG4105CRQ synthase (Component I) CJ306_06590 ENOG4105DDQ anthranilate synthase CJ306_06600 ENOG4105DK0 Indole-3-glycerol phosphate synthase CJ306_06610 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) CJ306_06615 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) CJ306_06685 ENOG4105C7S Dehydrogenase CJ306_06695 ENOG4105VZ8 Transcriptional regulator CJ306_06755 ENOG4105DZ1 carboxypeptidase CJ306_06760 ENOG4105VFR signal peptidase CJ306_06795 ENOG4105C26 Dehydrogenase CJ306_06800 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CJ306_06805 ENOG4105F38 ABC transporter, permease CJ306_06810 ENOG4105D38 putrescine abc transporter CJ306_06815 ENOG4107RUE extracellular solute-binding protein family 1 CJ306_06825 ENOG4105EYF MMPL domain protein CJ306_06835 ENOG4108YBP pseudouridine synthase CJ306_06845 ENOG4105K4I Scp-like extracellular CJ306_06850 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CJ306_06855 ENOG4105CQB FAD linked oxidase domain protein CJ306_06870 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CJ306_06875 ENOG4105BZU Histidine kinase CJ306_06880 ENOG4105JXH GntR family transcriptional regulator CJ306_06900 ENOG4106A3R peptidase CJ306_06910 ENOG4108QTI )-transporter CJ306_06915 ENOG4107TS3 membrane protein, TerC CJ306_06920 ENOG4105CZN Potassium uptake protein CJ306_06925 ENOG410681C small acid-soluble spore protein CJ306_06935 ENOG4108Z7G MaoC domain protein dehydratase CJ306_06955 ENOG4105CHR reductase CJ306_06990 ENOG4105C4Y ABC transporter CJ306_06995 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CJ306_07000 ENOG4107RCV ABC transporter, permease CJ306_07020 ENOG4105E98 transcriptional regulator DeoR family CJ306_07035 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) CJ306_07045 ENOG4105PXI polysaccharide deacetylase CJ306_07055 ENOG4105BZU Histidine kinase CJ306_07060 ENOG41090MY MarR family Transcriptional regulator CJ306_07070 ENOG4106DF1 CJ306_07080 ENOG4105BZU Histidine kinase CJ306_07085 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) CJ306_07090 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase CJ306_07095 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) CJ306_07140 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) CJ306_07170 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CJ306_07175 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family CJ306_07180 ENOG4105CZV ABC transporter CJ306_07190 ENOG4105CJ1 ABC, transporter CJ306_07230 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A CJ306_07235 ENOG4105EA8 2-Nitropropane dioxygenase CJ306_07240 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD CJ306_07250 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein CJ306_07275 ENOG4105NQC Flavodoxin CJ306_07320 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CJ306_07350 ENOG4105CZN Potassium uptake protein CJ306_07355 ENOG41063Y9 CJ306_07360 ENOG4105KBJ sporulation protein ytfj CJ306_07390 ENOG4105CM2 brancheD-chain amino acid aminotransferase CJ306_07395 ENOG4105C7K acetolactate synthase CJ306_07400 ENOG4108ZP8 Acetolactate synthase small subunit CJ306_07405 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CJ306_07420 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CJ306_07435 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) CJ306_07440 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) CJ306_07445 ENOG4105ECC imidazole-glycerol-phosphate dehydratase CJ306_07450 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CJ306_07455 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase CJ306_07460 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) CJ306_07470 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase CJ306_07475 ENOG4107RVV histidinol phosphate phosphatase, hisj family CJ306_07490 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase CJ306_07495 ENOG4105E0M Sulfatase CJ306_07505 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CJ306_07520 ENOG4107S4M Sulfate adenylate transferase CJ306_07525 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) CJ306_07530 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) CJ306_07540 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CJ306_07545 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein CJ306_07550 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein CJ306_07560 ENOG4105C8J )-transporter CJ306_07580 ENOG4105DFD Na H antiporter CJ306_07600 ENOG4105ENE Histidine kinase CJ306_07605 ENOG4105WH1 Two component transcriptional regulator luxr family CJ306_07625 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CJ306_07650 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CJ306_07675 ENOG4105CJ3 phosphate transporter CJ306_07680 ENOG4107GRR phosphate transport regulator CJ306_07685 ENOG4105BZ4 penicillin-binding protein CJ306_07700 ENOG4105BZU Histidine kinase CJ306_07705 ENOG4105I3N Conserved Protein CJ306_07720 ENOG4105BZU Histidine kinase CJ306_07725 ENOG4105D3A purine nucleoside phosphorylase DeoD-type CJ306_07750 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CJ306_07755 ENOG4105DZ1 carboxypeptidase CJ306_07760 ENOG4108JIC nucleoside recognition domain protein CJ306_07770 ENOG4105FE9 pseudouridine synthase CJ306_07775 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CJ306_07780 ENOG4107TWT Cytochrome c biogenesis protein CJ306_07785 ENOG4105CRE cytochrome C CJ306_07790 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CJ306_07795 ENOG4105BZU Histidine kinase CJ306_07800 ENOG4108WBT adenosyltransferase CJ306_07815 ENOG4108SAX Membrane CJ306_07830 ENOG4105C9U ATP-dependent DNA helicase RecQ CJ306_07835 ENOG4105I7S Abortive infection protein CJ306_07845 ENOG4107RGJ metallophosphoesterase CJ306_07850 ENOG4108XDN Transcriptional regulator CJ306_07855 ENOG4108S6Z Negative regulator of genetic competence CJ306_07880 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase CJ306_07885 ENOG4107RB3 L-asparaginase CJ306_07905 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) CJ306_07920 ENOG4105S2F CJ306_07925 ENOG41065D1 CJ306_07955 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) CJ306_07970 ENOG4105XXQ heptaprenyl diphosphate synthase component I CJ306_07980 ENOG4105EAH synthase CJ306_07985 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) CJ306_07990 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CJ306_07995 ENOG4105D49 3-dehydroquinate synthase CJ306_08005 ENOG41068YB TPR repeat-containing protein CJ306_08020 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) CJ306_08025 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) CJ306_08060 ENOG4108JYZ YitT family CJ306_08070 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase CJ306_08075 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) CJ306_08085 ENOG4105FJR Lmbe family CJ306_08090 ENOG4105CPK Glycosyl transferase (Group 1 CJ306_08115 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) CJ306_08130 ENOG4105DVT helicase CJ306_08135 ENOG4105YAC CJ306_08155 ENOG4105CSM endonuclease III CJ306_08165 ENOG4105BZ4 penicillin-binding protein CJ306_08210 ENOG4106F55 Protein of unknown function (DUF1273) CJ306_08225 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) CJ306_08235 ENOG4105DVT helicase CJ306_08240 ENOG4105CTD carboxy-peptidase CJ306_08250 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CJ306_08255 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) CJ306_08260 ENOG4105C2W permease CJ306_08265 ENOG4105DHF Membrane CJ306_08275 ENOG410890F Dynamin family CJ306_08285 ENOG4108W0I acetyltransferase CJ306_08295 ENOG4105KHC sulfurtransferase CJ306_08330 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic CJ306_08350 ENOG4105HTX biosynthesis protein CJ306_08380 ENOG4105CPK Glycosyl transferase (Group 1 CJ306_08395 ENOG4108SZE gCN5-related N-acetyltransferase CJ306_08415 ENOG41081VK Ribonuclease CJ306_08480 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CJ306_08490 ENOG4107RWR Sodium hydrogen exchanger CJ306_08495 ENOG4105CN5 Metallo-Beta-Lactamase CJ306_08500 ENOG4108Z5V transcriptional regulator, merr family CJ306_08515 ENOG4105H67 Protein of unknown function (DUF421) CJ306_08520 ENOG41080C8 DUF218 domain CJ306_08555 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CJ306_08565 ENOG4107R0U MotA TolQ exbB proton channel CJ306_08570 ENOG4105ER2 Ompa motb domain protein CJ306_08575 ENOG4107YTP response regulator receiver protein CJ306_08580 ENOG4105CBS Chea signal transduction histidine kinase CJ306_08585 ENOG4105DD5 Flagellar motor switch protein CJ306_08600 ENOG4105BZU Histidine kinase CJ306_08620 ENOG4105E1Q flagellar hook-associated protein CJ306_08625 ENOG4105DTJ flagellar hook-associated protein CJ306_08645 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) CJ306_08650 ENOG4108ZC9 flagellar basal-body rod protein flgc CJ306_08655 ENOG41075Z6 flagellar hook-basal body complex protein fliE CJ306_08660 ENOG4107U2N Flagellar M-ring protein CJ306_08665 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CJ306_08695 ENOG4105BZE flagellar hook protein, FlgE CJ306_08710 ENOG4107R88 Chemotaxis protein (CheV) CJ306_08720 ENOG4105I03 Flagellin CJ306_08725 ENOG4105I03 Flagellin CJ306_08730 ENOG4105E4C Lytic transglycosylase catalytic CJ306_08740 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CJ306_08745 ENOG4105DD5 Flagellar motor switch protein CJ306_08755 ENOG4105CN7 Flagellar biosynthetic protein FliP CJ306_08760 ENOG4105VS8 Flagellar biosynthetic protein fliq CJ306_08770 ENOG4105D00 flagellar biosynthetic protein flhB CJ306_08775 ENOG4105D7B Flagellar biosynthesis protein flha CJ306_08780 ENOG4105FZW flagellar biosynthesis regulator FlhF CJ306_08785 ENOG4105KTQ flagellar basal-body rod protein CJ306_08790 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CJ306_08825 ENOG4105KAC Antibiotic biosynthesis monooxygenase CJ306_08850 ENOG4105DUM transcriptional regulator, lysR family CJ306_08855 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CJ306_08865 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component CJ306_08870 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) CJ306_08900 ENOG4105CVJ phosphoglycerate mutase CJ306_08910 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) CJ306_08930 ENOG4105CAQ asparagine synthetase CJ306_08950 ENOG4105PGM cation diffusion facilitator family transporter CJ306_08960 ENOG4105DRR Transcriptional regulator, GntR family CJ306_08965 ENOG4108UZ3 Transporter CJ306_08975 ENOG4105CKI cobalamin synthesis protein CJ306_08980 ENOG4108PJD permease CJ306_08995 ENOG4105DFD Na H antiporter CJ306_09000 ENOG4105VUF Transcriptional regulator CJ306_09010 ENOG4105C9Q fumarate hydratase class II CJ306_09025 ENOG4107QJQ Mate efflux family protein CJ306_09030 ENOG4105EC3 peptidase S51, dipeptidase E CJ306_09050 ENOG4107QIV Cytochrome c biogenesis protein CJ306_09065 ENOG4107JM4 Tetratricopeptide repeat CJ306_09080 ENOG4105BZC d-serine deaminase CJ306_09085 ENOG4106BRA Membrane CJ306_09125 ENOG4105CJ1 ABC, transporter CJ306_09145 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) CJ306_09170 ENOG4108IJ0 Aspartate ammonia-lyase CJ306_09175 ENOG4105C6K Malic enzyme CJ306_09235 ENOG4105FVX CJ306_09240 ENOG4105E09 nadh pyrophosphatase CJ306_09255 ENOG4105CSR polyphosphate kinase 2 CJ306_09260 ENOG4105U3E Transcriptional regulator CJ306_09270 ENOG4105DXI Major Facilitator superfamily CJ306_09280 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CJ306_09285 ENOG4105EU0 Major facilitator Superfamily CJ306_09290 ENOG4105C6T cysteine synthase CJ306_09310 ENOG4105C8J )-transporter CJ306_09320 ENOG4105X5K response regulator receiver protein CJ306_09325 ENOG4105H67 Protein of unknown function (DUF421) CJ306_09350 ENOG4106KE4 Dehydrogenase CJ306_09370 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CJ306_09375 ENOG4105CHR reductase CJ306_09380 ENOG4105CM2 brancheD-chain amino acid aminotransferase CJ306_09385 ENOG4105C7K acetolactate synthase CJ306_09395 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CJ306_09405 ENOG4105C7B Threonine dehydratase CJ306_09430 ENOG4105C6X Major Facilitator CJ306_09435 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b CJ306_09445 ENOG4105DY9 regulatoR CJ306_09450 ENOG4105CYC Transferase CJ306_09465 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) CJ306_09470 ENOG4105EQ0 Major Facilitator superfamily CJ306_09475 ENOG4108IND Tetr family transcriptional regulator CJ306_09480 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CJ306_09505 ENOG4105MSY salicylate hydroxylase CJ306_09520 ENOG41068WN CJ306_09540 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) CJ306_09560 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) CJ306_09565 ENOG4105C0X amino acid CJ306_09615 ENOG410849A acetyltransferase, (GNAT) family CJ306_09625 ENOG4105K8R UPF0145 protein CJ306_09640 ENOG4107RHR regulatoR CJ306_09650 ENOG4105D9N nucleoside CJ306_09655 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) CJ306_09675 ENOG4107RAQ aminopeptidase CJ306_09685 ENOG4107R16 Multicopper oxidase CJ306_09725 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family CJ306_09775 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CJ306_09780 ENOG4108KP7 hydrolase CJ306_09785 ENOG4105C8V SAICAR synthetase CJ306_09795 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) CJ306_09800 ENOG4105CHR reductase CJ306_09825 ENOG4108T5E Copper resistance protein CJ306_09830 ENOG4105KTB nuclear export factor GLE1 CJ306_09835 ENOG4107RT3 EamA-like transporter family CJ306_09840 ENOG4105GZI Transcriptional regulator CJ306_09845 ENOG4108Z40 Transcriptional regulator CJ306_09850 ENOG4107ZXU DSBA oxidoreductase CJ306_09855 ENOG4108TVJ Nitroreductase CJ306_09870 ENOG4106F5Q Membrane CJ306_09875 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CJ306_09890 ENOG4105CKI cobalamin synthesis protein CJ306_09900 ENOG4105C0Z ABC transporter CJ306_09905 ENOG4108IV0 ABC, transporter CJ306_09910 ENOG4105C32 Amino acid ABC transporter (Permease) CJ306_09920 ENOG4105SKE transcriptional Regulator LysR family CJ306_09955 ENOG4105C4M (Ubiquinol oxidase) subunit I CJ306_09960 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CJ306_09965 ENOG4108JJ9 ABC, transporter CJ306_09970 ENOG4108JJ8 (ABC) transporter CJ306_09990 ENOG4108UT6 Transferase hexapeptide repeat containing protein CJ306_10045 ENOG4105BZ1 (ABC) transporter CJ306_10050 ENOG4105EFI regulatoR CJ306_10055 ENOG4105BZU Histidine kinase CJ306_10070 ENOG41075D4 Aminoglycoside 6-adenylyltransferase CJ306_10075 ENOG4108ZJ4 polysaccharide deacetylase CJ306_10095 ENOG4105D6E homoserine dehydrogenase CJ306_10105 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) CJ306_10120 ENOG4108KGH TRANSCRIPTIONal CJ306_10130 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CJ306_10135 ENOG4105BZU Histidine kinase CJ306_10140 ENOG4107VMI polysaccharide deacetylase CJ306_10150 ENOG4105KT7 mgtC SapB transporter CJ306_10155 ENOG4105VRR gCN5-related N-acetyltransferase CJ306_10165 ENOG4105DUU IucA IucC family protein CJ306_10170 ENOG4105CEY Amp-dependent synthetase and ligase CJ306_10185 ENOG4108WBH protein TIM barrel CJ306_10190 ENOG4105YWU small acid-soluble spore protein CJ306_10200 ENOG4108ZUB Lysine exporter protein (Lyse ygga) CJ306_10205 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CJ306_10255 ENOG4105KRN Transcriptional regulator, abrb family CJ306_10265 ENOG4105YVS arsR family transcriptional regulator CJ306_10270 ENOG4105CPC Aldo Keto reductase CJ306_10275 ENOG4107XZQ multidrug resistance protein CJ306_10285 ENOG4105KAF membrAne CJ306_10310 ENOG4105C8Q Methyl-accepting chemotaxis CJ306_10330 ENOG4108K88 Membrane CJ306_10335 ENOG4108WPJ Ferritin-like domain CJ306_10350 ENOG4105DEN Luciferase family CJ306_10365 ENOG4105VMI -acetyltransferase CJ306_10370 ENOG4107QM2 Aldo Keto reductase CJ306_10380 ENOG4105CKI cobalamin synthesis protein CJ306_10390 ENOG4105DSE periplasmic solute binding protein CJ306_10400 ENOG4105K4T epimerase CJ306_10410 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CJ306_10455 ENOG4107T5V SNARE associated Golgi CJ306_10470 ENOG4108PJD permease CJ306_10480 ENOG4108S4H thioesterase Superfamily protein CJ306_10490 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CJ306_10510 ENOG4105SXS Protein of unknown function (DUF456) CJ306_10515 ENOG4105C37 (CBS) domain CJ306_10535 ENOG4108Z7R Chaperone CsaA CJ306_10555 ENOG4108ZRV stage ii sporulation protein p CJ306_10565 ENOG4108VXD carboxy-peptidase CJ306_10575 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CJ306_10610 ENOG4108X4Q Hydrolase CJ306_10625 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CJ306_10645 ENOG41087PP glycosyltransferase MGT family CJ306_10650 ENOG4108JYZ YitT family CJ306_10655 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CJ306_10685 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) CJ306_10705 ENOG4106PAW secretion accessory protein EsaA YueB CJ306_10715 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) CJ306_10720 ENOG4108MGT Required for secretion of EsxA and EsxB CJ306_10825 ENOG4105KBJ sporulation protein ytfj CJ306_10850 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CJ306_10870 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) CJ306_10875 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily CJ306_10885 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein CJ306_10890 ENOG4105EMN RNA polymerase sigma factor CJ306_10905 ENOG4105CNW domain protein CJ306_10915 ENOG4108V06 Glutathione peroxidase CJ306_10930 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CJ306_10940 ENOG4108IUE nitrate reductase beta subunit CJ306_10945 ENOG4105R3A Nitrate reductase CJ306_10955 ENOG4107V6Q Cyclic nucleotide-binding domain CJ306_10960 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CJ306_10965 ENOG4105D06 uba thif-type nad fad binding protein CJ306_10970 ENOG4105CVM Molybdenum cofactor synthesis domain protein CJ306_10975 ENOG4108ZAF Molybdopterin CJ306_11005 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein CJ306_11010 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein CJ306_11015 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CJ306_11020 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit CJ306_11025 ENOG4108IFG nitrite reductase, (NAD(P)H) CJ306_11030 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) CJ306_11065 ENOG4105MCT stage V sporulation protein S CJ306_11100 ENOG4107T65 Integrase CJ306_11105 ENOG410635T phage-like element pbsx protein CJ306_11115 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) CJ306_11130 ENOG4108IMY Transcriptional regulator CJ306_11245 ENOG4108C33 Resolvase CJ306_11260 ENOG4105IG6 Phage terminase, large subunit CJ306_11395 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis CJ306_11430 ENOG4105C5H ABC transporter CJ306_11450 ENOG4105EKQ RNA-directed DNA polymerase CJ306_11475 ENOG4107YX5 Pfam:DUF548 CJ306_11480 ENOG4105C75 arginyL-tRNA synthetase CJ306_11505 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CJ306_11525 ENOG4105C5S asparaginyl-tRNA synthetase CJ306_11530 ENOG4105C8J )-transporter CJ306_11550 ENOG4107XGZ Hydrolase CJ306_11555 ENOG4105CY2 Citrate transporter CJ306_11575 ENOG4105KD7 acetyltransferase CJ306_11585 ENOG4105VMP Transcriptional regulator CJ306_11590 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase CJ306_11615 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 CJ306_11630 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) CJ306_11635 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) CJ306_11645 ENOG4107RVG penicillin-binding protein CJ306_11650 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) CJ306_11655 ENOG4105E9Q Acyl-transferase CJ306_11660 ENOG4108UT2 hemolysin iii CJ306_11670 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CJ306_11680 ENOG4108RCR degv family CJ306_11690 ENOG4108KF3 Electron transport protein SCO1 SenC CJ306_11695 ENOG4107Y70 Heat shock protein CJ306_11700 ENOG4105CAQ asparagine synthetase CJ306_11715 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CJ306_11720 ENOG4108MES Periplasmic binding protein CJ306_11725 ENOG4105F0I Aminotransferase CJ306_11760 ENOG4105D8X mechanosensitive ion channel CJ306_11765 ENOG4105BZU Histidine kinase CJ306_11770 ENOG4105WH1 Two component transcriptional regulator luxr family CJ306_11775 ENOG4106KNT transcriptional regulator CJ306_11780 ENOG4107ZY0 Phenazine biosynthesis-like protein CJ306_11800 ENOG4105CMG Carbohydrate kinase CJ306_11805 ENOG4105C6Z Gluconate CJ306_11815 ENOG4108YV3 Protein of unknown function (DUF2711) CJ306_11845 ENOG4108IJ8 ABC transporter CJ306_11850 ENOG4105E90 ABC transporter CJ306_11885 ENOG4105C37 (CBS) domain CJ306_11915 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CJ306_11930 ENOG4107S4Y M20 DapE family protein YgeY CJ306_11935 ENOG4108TSC N-acetyltransferase CJ306_11940 ENOG4108JUB Transcriptional regulator CJ306_11945 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein CJ306_11990 ENOG410841Q phosphoesterase PA-phosphatase related protein CJ306_12000 ENOG4105SZ6 Thioredoxin CJ306_12065 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CJ306_12120 ENOG4105BZ4 penicillin-binding protein CJ306_12130 ENOG4105CZM Major Facilitator CJ306_12135 ENOG4105W8X HesB YadR YfhF-family protein CJ306_12145 ENOG4105DXD 2-methylcitrate dehydratase CJ306_12150 ENOG4105CR4 methylisocitrate lyase CJ306_12155 ENOG4105C1G acyl-Coa dehydrogenase CJ306_12160 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CJ306_12170 ENOG4105N14 lysine exporter protein LysE YggA CJ306_12175 ENOG4105E39 Enoyl-CoA hydratase CJ306_12190 ENOG4107RFY SbcCD D subunit CJ306_12195 ENOG4105EYH Exonuclease CJ306_12225 ENOG4105FCD Major Facilitator CJ306_12235 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase CJ306_12240 ENOG4105E4F Isochorismate synthase CJ306_12245 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase CJ306_12250 ENOG4105WQI isochorismatase CJ306_12255 ENOG4105CEY Amp-dependent synthetase and ligase CJ306_12260 ENOG4105WQT MbtH domain protein CJ306_12265 ENOG4105C0R drug resistance transporter emrb qaca subfamily CJ306_12280 ENOG4105K70 DNA-binding protein CJ306_12300 ENOG4105BZG amino acid carrier protein CJ306_12320 ENOG4105FE9 pseudouridine synthase CJ306_12325 ENOG4105C22 threonyL-tRNA synthetase CJ306_12330 ENOG4105C19 ABC transporter CJ306_12370 ENOG41081I9 integral membrane protein CJ306_12380 ENOG4108Y4K DNA-binding transcriptional activator CJ306_12395 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CJ306_12405 ENOG4105EYF MMPL domain protein CJ306_12440 ENOG4105WCN acetyltransferase CJ306_12465 ENOG4105C1Q protoporphyrinogen oxidase CJ306_12475 ENOG41068WN CJ306_12505 ENOG4107V2S Transcriptional regulator CJ306_12510 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CJ306_12530 ENOG4105DND Transcriptional regulator CJ306_12535 ENOG4108RPX mosc domain containing protein CJ306_12550 ENOG4105BZ1 (ABC) transporter CJ306_12555 ENOG4105BZ1 (ABC) transporter CJ306_12585 ENOG4105VTR Integrase CJ306_12615 ENOG4108ZUE Phage regulatory protein rha CJ306_12640 ENOG4106CVF DNA replication protein CJ306_12650 ENOG4105KRN Transcriptional regulator, abrb family CJ306_12820 ENOG4108SKK alpha helix protein CJ306_12845 ENOG4105XSJ toxin secretion phage lysis holin CJ306_12850 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase CJ306_12865 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CJ306_12915 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) CJ306_12920 ENOG4108KPJ rna polymerase sigma factor CJ306_12955 ENOG4105F32 YngK protein CJ306_12975 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) CJ306_12980 ENOG4105RD7 BadF BadG BcrA BcrD CJ306_12985 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CJ306_12990 ENOG4107STF Involved in phosphonate degradation (By similarity) CJ306_12995 ENOG4105C7B Threonine dehydratase CJ306_13000 ENOG4108INS Transcriptional regulator CJ306_13025 ENOG4105C1J atp-dependent rna helicase CJ306_13045 ENOG4108RZE Tetr family transcriptional regulator CJ306_13155 ENOG41088CC tellurite resistance protein tehB CJ306_13165 ENOG4108I0C methyltransferase CJ306_13170 ENOG4107RA9 decarboxylase CJ306_13175 ENOG4105K56 Transcriptional regulator CJ306_13180 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CJ306_13210 ENOG4105CIN aminoacyl-histidine dipeptidase CJ306_13245 ENOG4105KRN Transcriptional regulator, abrb family CJ306_13255 ENOG4105EJ9 Membrane CJ306_13260 ENOG4105EQK -acetyltransferase CJ306_13395 ENOG4108IG5 Transcriptional regulator CJ306_13430 ENOG4105ED2 Beta-lactamase CJ306_13460 ENOG4105FQP Beta-lactamase CJ306_13465 ENOG4107RVG penicillin-binding protein CJ306_13480 ENOG4107RF6 penicillin-binding protein CJ306_13485 ENOG4107RF6 penicillin-binding protein CJ306_13495 ENOG4105DIN metallophosphoesterase CJ306_13505 ENOG4105CJ1 ABC, transporter CJ306_13515 ENOG4107Z3H Transcriptional regulator, TetR family CJ306_13530 ENOG4105C1G acyl-Coa dehydrogenase CJ306_13535 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CJ306_13540 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit CJ306_13545 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase CJ306_13550 ENOG4105E39 Enoyl-CoA hydratase CJ306_13555 ENOG4107QX3 carboxylase CJ306_13560 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CJ306_13600 ENOG4105DZ1 carboxypeptidase CJ306_13615 ENOG4105T9C HD domain CJ306_13630 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) CJ306_13650 ENOG41075H3 AraC family transcriptional regulator CJ306_13680 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CJ306_13690 ENOG4107Y80 Major Facilitator superfamily CJ306_13695 ENOG4105CHR reductase CJ306_13700 ENOG4105KVH Transcriptional regulator CJ306_13765 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) CJ306_13785 ENOG4105DK7 lysyl-tRNA synthetase CJ306_13860 ENOG4105D6E homoserine dehydrogenase CJ306_13870 ENOG4105CPF Cell wall formation (By similarity) CJ306_13875 ENOG4105ETU transcriptional activator (TenA CJ306_13905 ENOG4105VTR Integrase CJ306_13945 ENOG4105KRN Transcriptional regulator, abrb family CJ306_14060 ENOG4105CAR Terminase, large subunit CJ306_14070 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CJ306_14130 ENOG4105XSJ toxin secretion phage lysis holin CJ306_14220 ENOG410667J hydrolase CJ306_14230 ENOG4105BZU Histidine kinase CJ306_14235 ENOG4107RF6 penicillin-binding protein CJ306_14260 ENOG4108JJB ABC transporter CJ306_14275 ENOG4108HGU Histidine kinase CJ306_14280 ENOG4105VTR Integrase CJ306_14355 ENOG4105CB2 alcohol dehydrogenase CJ306_14360 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase CJ306_14365 ENOG4105CJN penicillin-binding protein CJ306_14410 ENOG4107Y80 Major Facilitator superfamily CJ306_14430 ENOG4107VXM glycerophosphoryl diester phosphodiesterase CJ306_14455 ENOG4107Y9U Membrane CJ306_14500 ENOG4105FCD Major Facilitator CJ306_14510 ENOG4105E09 nadh pyrophosphatase CJ306_14515 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CJ306_14535 ENOG4108XI2 Domain of unknown function (DUF1963) CJ306_14560 ENOG4108NRW Phospholipase, patatin family CJ306_14565 ENOG4105KWG Pfam:DUF1696 CJ306_14575 ENOG4108YYS metal-dependent hydrolase (By similarity) CJ306_14590 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CJ306_14600 ENOG4105PKS Excinuclease abc c subunit domain protein CJ306_14635 ENOG41087PP glycosyltransferase MGT family CJ306_14650 ENOG4107VFR oxidoreductase CJ306_14680 ENOG4105U0R haloacid dehalogenase-like hydrolase CJ306_14685 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CJ306_14690 ENOG4105BZU Histidine kinase CJ306_14730 ENOG4107WD8 ABC transporter, permease CJ306_14745 ENOG4105DY8 decarboxylase CJ306_14760 ENOG4108IUM Glycogen debranching enzyme CJ306_14770 ENOG4105CGH 5'-nucleotidase CJ306_14795 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CJ306_14800 ENOG4105FDR Membrane CJ306_14810 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) CJ306_14855 ENOG4105MSI germination protein ypeb CJ306_14885 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) CJ306_14890 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) CJ306_14895 ENOG4107Z3H Transcriptional regulator, TetR family CJ306_14930 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family CJ306_14950 ENOG4105E98 transcriptional regulator DeoR family CJ306_14965 ENOG41062ES Transcriptional regulator CJ306_14985 ENOG4107QKR Dehydrogenase CJ306_14995 ENOG4107RUY (E1 component), alpha subunit CJ306_15005 ENOG4105E1F short-chain dehydrogenase reductase CJ306_15010 ENOG4105RHY Pfam:UPF0157 CJ306_15045 ENOG4107SQ8 Glycine betaine CJ306_15050 ENOG4108IJ7 Glycine betaine CJ306_15060 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CJ306_15075 ENOG4105E66 phosphoriboisomerase A CJ306_15080 ENOG41082BV acetyltransferase CJ306_15085 ENOG4108M1A Chitin-binding protein CJ306_15100 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) CJ306_15115 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CJ306_15120 ENOG4105MSB protein, conserved in bacteria CJ306_15140 ENOG4108Z7F N-acetyltransferase CJ306_15160 ENOG4105KEG ribosomal-protein-alanine acetyltransferase CJ306_15165 ENOG4105EEM helicase CJ306_15180 ENOG4105C9U ATP-dependent DNA helicase RecQ CJ306_15245 ENOG4108M1A Chitin-binding protein CJ306_15265 ENOG4105BZG amino acid carrier protein CJ306_15270 ENOG4105C26 Dehydrogenase CJ306_15275 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CJ306_15280 ENOG4105CTU Proline racemase CJ306_15285 ENOG4105CTU Proline racemase CJ306_15290 ENOG41080HI glycine oxidase CJ306_15300 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein CJ306_15330 ENOG4107T5V SNARE associated Golgi CJ306_15340 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD CJ306_15360 ENOG4105DTQ mandelate racemase muconate lactonizing CJ306_15375 ENOG4107SET aldo keto reductase CJ306_15410 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) CJ306_15415 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CJ306_15420 ENOG4105BZU Histidine kinase CJ306_15425 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CJ306_15460 ENOG4105DPN Oligoendopeptidase f CJ306_15465 ENOG4105EPR degv family CJ306_15525 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) CJ306_15530 ENOG4106K7D Major facilitator family transporter CJ306_15555 ENOG4107BMA Transglycosylase associated protein CJ306_15570 ENOG41089UC methyltransferase, type 11 CJ306_15610 ENOG4105CHM Aminotransferase CJ306_15640 ENOG4105DVE abc transporter atp-binding protein CJ306_15695 ENOG4105C02 permease CJ306_15710 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) CJ306_15715 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CJ306_15720 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein CJ306_15725 ENOG4105D7T ABC transporter CJ306_15760 ENOG4108AQF aminoglycoside N(3)-acetyltransferase CJ306_15800 ENOG4107VC0 DNA alkylation repair enzyme CJ306_15805 ENOG4105C6T cysteine synthase CJ306_15810 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase CJ306_15820 ENOG4107VMI polysaccharide deacetylase CJ306_15830 ENOG4108ZCF integral membrane protein CJ306_15835 ENOG4105E0M Sulfatase CJ306_15840 ENOG4105C5H ABC transporter CJ306_15850 ENOG4105EYF MMPL domain protein CJ306_15855 ENOG41082JN Transcriptional regulator CJ306_15875 ENOG4105CIH Imidazole acetol-phosphate transaminase CJ306_15880 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CJ306_15890 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase CJ306_15940 ENOG41069ER domain protein CJ306_15950 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase CJ306_15980 ENOG4105D4B ABC, transporter CJ306_15990 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane CJ306_16000 ENOG4105DKT Transcriptional regulator CJ306_16005 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) CJ306_16015 ENOG41061GT Aldolase CJ306_16030 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) CJ306_16070 ENOG4105II7 pyrroline-5-carboxylate reductase CJ306_16080 ENOG4107258 Transcriptional regulator CJ306_16100 ENOG4105ECK Fatty Acid Desaturase CJ306_16110 ENOG4107RBI VanW family CJ306_16115 ENOG4105G6Z alkaline phosphatase CJ306_16125 ENOG4105VMP Transcriptional regulator CJ306_16145 ENOG41068WN CJ306_16175 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CJ306_16230 ENOG4105C8Y Acetylornithine aminotransferase CJ306_16280 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CJ306_16305 ENOG4108IBT Inherit from COG: transposase CJ306_16325 ENOG4108TVJ Nitroreductase CJ306_16330 ENOG4105FS7 Transcriptional regulator CJ306_16350 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) CJ306_16370 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family CJ306_16380 ENOG4105CMR udp-glucose 4-epimerase CJ306_16385 ENOG4105C19 ABC transporter CJ306_16405 ENOG4108DMH HTH_ARAC CJ306_16410 ENOG4108XET gCN5-related N-acetyltransferase CJ306_16435 ENOG4107XJU UPF0178 protein CJ306_16470 ENOG410635A Membrane CJ306_16480 ENOG4108IQI permease CJ306_16490 ENOG4105F1N DNA alkylation repair CJ306_16525 ENOG4107RF6 penicillin-binding protein CJ306_16535 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CJ306_16560 ENOG4105E7W lamb ycsf family protein CJ306_16570 ENOG4105P4J Allophanate hydrolase, subunit 1 CJ306_16575 ENOG4107258 Transcriptional regulator CJ306_16585 ENOG4106N3A copper homeostasis protein cutc CJ306_16590 ENOG4108ZHR arsR family transcriptional regulator CJ306_16600 ENOG4105FDT acyl-CoA dehydrogenase CJ306_16615 ENOG4105DWD nucleoside recognition domain protein CJ306_16655 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) CJ306_16730 ENOG4105E2A Dehydrogenase CJ306_16745 ENOG4108IJ0 Aspartate ammonia-lyase CJ306_16750 ENOG4105HDK L-asparaginase CJ306_16755 ENOG4108IMY Transcriptional regulator CJ306_16780 ENOG4108B31 Spore germination protein CJ306_16790 ENOG4105BZU Histidine kinase CJ306_16815 ENOG41075H3 AraC family transcriptional regulator CJ306_16830 ENOG4105YWU small acid-soluble spore protein CJ306_16835 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CJ306_16840 ENOG4105CUB amino acid CJ306_16850 ENOG4105II7 pyrroline-5-carboxylate reductase CJ306_16860 ENOG4105C6K Malic enzyme CJ306_16870 ENOG4108NHD germination protein CJ306_16875 ENOG4108Q8B Spore germination protein CJ306_16940 ENOG4105CGH 5'-nucleotidase CJ306_16950 ENOG4105CHJ isochorismatase hydrolase CJ306_16975 ENOG41090MY MarR family Transcriptional regulator CJ306_17000 ENOG4105F6J Alpha beta hydrolase fold CJ306_17015 ENOG4108606 TspO/MBR family CJ306_17020 ENOG4105CVP deoxyribo-dipyrimidine photolyase CJ306_17045 ENOG4108TWJ NADH dehydrogenase subunit 5 CJ306_17050 ENOG4105GPN Uncharacterized conserved protein (DUF2294) CJ306_17065 ENOG4105E1K spore germination protein CJ306_17070 ENOG4107VMI polysaccharide deacetylase CJ306_17075 ENOG4105KY5 gCN5-related N-acetyltransferase CJ306_17080 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CJ306_17085 ENOG4105ECQ AraC Family Transcriptional Regulator CJ306_17100 ENOG4105D6J arsenicaL-resistance protein CJ306_17105 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase CJ306_17110 ENOG41085FC arsR family transcriptional regulator CJ306_17125 ENOG4105NAE bifunctional deaminase-reductase domain protein CJ306_17130 ENOG4107P5I polyketide synthase CJ306_17135 ENOG4108IG5 Transcriptional regulator CJ306_17140 ENOG4105F27 Major Facilitator CJ306_17145 ENOG4105M4P Tetr family transcriptional regulator CJ306_17150 ENOG4105CHR reductase CJ306_17155 ENOG4108YXU transcriptional regulator AsnC family CJ306_17225 ENOG4105N0V mono-oxygenase ydhR CJ306_17255 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CJ306_17260 ENOG41062D9 Histidine kinase CJ306_17285 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CJ306_17290 ENOG4105C0R drug resistance transporter emrb qaca subfamily CJ306_17315 ENOG4105K6H D-cysteine desulfhydrase CJ306_17340 ENOG4108NNI Beta-lactamase domain-containing protein CJ306_17345 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase CJ306_17355 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CJ306_17360 ENOG4105JQZ Methyltransferase CJ306_17380 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) CJ306_17400 ENOG4105BZU Histidine kinase CJ306_17415 ENOG4108U05 Transcriptional regulator CJ306_17420 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 CJ306_17430 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) CJ306_17440 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A CJ306_17465 ENOG4108JQ1 Dehydrogenase CJ306_17470 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) CJ306_17485 ENOG41082W1 Cupin 2, conserved barrel domain protein CJ306_17495 ENOG410874W AraC family transcriptional regulator CJ306_17515 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CJ306_17920 ENOG4108VXD carboxy-peptidase CJ306_17925 ENOG4105PNM synthesis protein CJ306_17935 ENOG4108ISG Major Facilitator CJ306_17950 ENOG4107MII Sugar-specific transcriptional regulator TrmB CJ306_17955 ENOG4105CZM Major Facilitator CJ306_17970 ENOG4105CRW Short chain fatty acid transporter CJ306_17985 ENOG4105DYS nad(p)h dehydrogenase (quinone) CJ306_18045 ENOG4108K8S endonuclease I CJ306_18050 ENOG4108Z66 YbaK ebsC protein CJ306_18055 ENOG4105CUT histidyl-tRNA synthetase CJ306_18070 ENOG4105KVH Transcriptional regulator CJ306_18075 ENOG4108RCM Nitroreductase CJ306_18110 ENOG4108PSK reductase CJ306_18180 ENOG4105C31 Tryptophanyl-tRNA synthetase CJ306_18185 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) CJ306_18220 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) CJ306_18230 ENOG4105EV4 Multidrug resistance protein mdtH CJ306_18260 ENOG4105C37 (CBS) domain CJ306_18275 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase CJ306_18280 ENOG4105FAW cDP-glucose 4,6-dehydratase CJ306_18310 ENOG4105DDN Pentapeptide repeat-containing protein CJ306_18315 ENOG4105XDF Protein of unknown function (DUF1272) CJ306_18320 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) CJ306_18325 ENOG4105CMG Carbohydrate kinase CJ306_18330 ENOG4105C6Z Gluconate CJ306_18345 ENOG4105CV1 Transketolase (EC 2.2.1.1) CJ306_18350 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CJ306_18355 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CJ306_18360 ENOG4105CIS alcohol dehydrogenase CJ306_18365 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone CJ306_18380 ENOG4105EWI Short-chain dehydrogenase reductase Sdr CJ306_18400 ENOG4105C8Q Methyl-accepting chemotaxis CJ306_18405 ENOG4108UX3 '-nucleotidase CJ306_18410 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CJ306_18415 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) CJ306_18420 ENOG4105KVH Transcriptional regulator CJ306_18440 ENOG4105CV8 reductase CJ306_18445 ENOG4105F27 Major Facilitator CJ306_18460 ENOG41090KN UPF0303 protein CJ306_18480 ENOG4105C44 Serine transporter CJ306_18520 ENOG4105KVH Transcriptional regulator CJ306_18525 ENOG4108TZY GntR Family Transcriptional Regulator CJ306_18530 ENOG4105D9R oxidoreductase CJ306_18535 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase CJ306_18540 ENOG4105KVH Transcriptional regulator CJ306_18545 ENOG4105KVH Transcriptional regulator CJ306_18595 ENOG4105JAB phenazine biosynthesis protein, phzf family CJ306_18605 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein CJ306_18610 ENOG4105KVH Transcriptional regulator CJ306_18625 ENOG4108ZJ4 polysaccharide deacetylase CJ306_18695 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) CJ306_18730 ENOG4105H3G oxidoreductase CJ306_18800 ENOG4108TN2 lmbE family CJ306_18810 ENOG4107R3E Citrate transporter CJ306_18820 ENOG4105WCN acetyltransferase CJ306_18825 ENOG4108MES Periplasmic binding protein CJ306_18830 ENOG4105EHG Permease protein CJ306_18835 ENOG4105DQ5 transport system permease protein CJ306_18840 ENOG4105NX3 Membrane CJ306_18845 ENOG4105EYF MMPL domain protein CJ306_18870 ENOG4107CUJ Protein of unknown function (DUF2690) CJ306_18880 ENOG4107V2S Transcriptional regulator CJ306_18900 ENOG4105C98 muts2 protein CJ306_18910 ENOG4105E5K Alpha-amylase CJ306_18915 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase CJ306_18920 ENOG4105DPN Oligoendopeptidase f CJ306_18960 ENOG4108A04 Beta-lactamase CJ306_18985 ENOG4107VXM glycerophosphoryl diester phosphodiesterase CJ306_18995 ENOG41082BM Transcriptional regulator, arsr family CJ306_19000 ENOG4105CIS alcohol dehydrogenase CJ306_19040 ENOG4105CQB FAD linked oxidase domain protein CJ306_19075 ENOG4105BZU Histidine kinase CJ306_19085 ENOG4105KT7 mgtC SapB transporter CJ306_19095 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase CJ306_19100 ENOG41073R8 VanW family CJ306_19110 ENOG4108R1P CJ306_19130 ENOG4105VEQ Cold shock protein CJ306_19150 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) CJ306_19170 ENOG410904N short-chain dehydrogenase reductase CJ306_19180 ENOG4106IQC argininosuccinate lyase CJ306_19195 ENOG4108IA2 Sodium pantothenate symporter CJ306_19200 ENOG4105RG0 Membrane CJ306_19205 ENOG4105C26 Dehydrogenase CJ306_19210 ENOG4105CHR reductase CJ306_19220 ENOG4105EWU Squalene--hopene cyclase CJ306_19230 ENOG4105FR1 rard protein CJ306_19235 ENOG410696E Membrane CJ306_19250 ENOG4105D1F ATP-binding protein CJ306_19260 ENOG4108ZAF Molybdopterin CJ306_19265 ENOG4105CVM Molybdenum cofactor synthesis domain protein CJ306_19270 ENOG4105D06 uba thif-type nad fad binding protein CJ306_19275 ENOG4105TMB Formate nitrite transporter CJ306_19290 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CJ306_19295 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) CJ306_19305 ENOG4108JB9 formate dehydrogenase CJ306_19315 ENOG4105E1K spore germination protein CJ306_19330 ENOG4105CUB amino acid CJ306_19385 ENOG4108KGH TRANSCRIPTIONal CJ306_19395 ENOG4105EMN RNA polymerase sigma factor CJ306_19405 ENOG4105CIG ABC transporter CJ306_19425 ENOG4105D9R oxidoreductase CJ306_19435 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CJ306_19445 ENOG4105K4P CoA-binding domain protein CJ306_19450 ENOG4105C0H protease CJ306_19455 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CJ306_19465 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase CJ306_19470 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CJ306_19475 ENOG4105W8X HesB YadR YfhF-family protein CJ306_19485 ENOG4105D7V transposase CJ306_19510 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CJ306_19515 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CJ306_19530 ENOG4105BZ1 (ABC) transporter CJ306_19535 ENOG4108I0Z Aconitate hydratase CJ306_19565 ENOG4105E5W Transporter CJ306_19575 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CJ306_19595 ENOG4107F3J Amp-dependent synthetase and ligase CJ306_19600 ENOG4107ZYJ bioY protein CJ306_19605 ENOG4105CEY Amp-dependent synthetase and ligase CJ306_19650 ENOG4107AYK membrAne CJ306_19665 ENOG4105BZU Histidine kinase CJ306_19670 ENOG4105FBA Phospholipase Carboxylesterase CJ306_19675 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase CJ306_19680 ENOG4105CK7 Sodium proline symporter CJ306_19685 ENOG4105CBC glutamate synthase CJ306_19690 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CJ306_19695 ENOG4108VJ1 Transcriptional regulator (CarD family CJ306_19700 ENOG4108903 Formimidoylglutamase CJ306_19710 ENOG4105CGP Urocanate hydratase CJ306_19760 ENOG4107QIV Cytochrome c biogenesis protein CJ306_19775 ENOG4105CH2 amidohydrolase CJ306_19785 ENOG4105CJ1 ABC, transporter CJ306_19800 ENOG4107RSM transcriptional regulator CJ306_19805 ENOG4105VAW lrga family CJ306_19810 ENOG41067MG lrgb family CJ306_19850 ENOG4105BZ1 (ABC) transporter CJ306_19855 ENOG4105BZ1 (ABC) transporter CJ306_19890 ENOG4108HW3 (ABC) transporter CJ306_19895 ENOG4105CGH 5'-nucleotidase CJ306_19905 ENOG4108SVB resolvase CJ306_19925 ENOG4105K7K Transcriptional regulator CJ306_19945 ENOG41065S2 pneumococcal vaccine antigen CJ306_19975 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) CJ306_19980 ENOG4105C5F glutamine synthetase CJ306_19985 ENOG4105KV4 Transcriptional regulator CJ306_19990 ENOG4105CXI aluminum resistance protein CJ306_19995 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CJ306_20000 ENOG4105EN6 Membrane CJ306_20005 ENOG4106F1P AAA ATPase, central domain protein CJ306_20045 ENOG41069ER domain protein CJ306_20055 ENOG4105DM4 PTS System CJ306_20060 ENOG4105DE4 1-phosphofructokinase CJ306_20065 ENOG4105E98 transcriptional regulator DeoR family CJ306_20070 ENOG4107QW4 alcohol dehydrogenase CJ306_20075 ENOG4108SJC Membrane CJ306_20090 ENOG4105C85 amino acid CJ306_20110 ENOG4105TMB Formate nitrite transporter CJ306_20115 ENOG4105K70 DNA-binding protein CJ306_20125 ENOG4105C59 p-type ATPase CJ306_20130 ENOG410681U heavy metal transport detoxification protein CJ306_20135 ENOG4105VPX protein, conserved in bacteria CJ306_20145 ENOG4105NIV Esterase CJ306_20150 ENOG4105E0A ABC, transporter CJ306_20170 ENOG4105CGK Exodeoxyribonuclease III CJ306_20180 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CJ306_20185 ENOG4105D03 DNA-3-methyladenine glycosylase II CJ306_20190 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CJ306_20210 ENOG4105BZU Histidine kinase CJ306_20250 ENOG41067MG lrgb family CJ306_20270 ENOG4108S3Y transcriptional regulator CJ306_20275 ENOG4105CS2 ec 3.2.1.21 CJ306_20290 ENOG4105F0V Cell wall hydrolase CJ306_20305 ENOG4105E0M Sulfatase CJ306_20340 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CJ306_20345 ENOG4105DQU oxidoreductase, subunit beta CJ306_20350 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein CJ306_20355 ENOG4108IGT Dipeptidase CJ306_20360 ENOG4105MCT stage V sporulation protein S CJ306_20365 ENOG4105D48 metallophosphoesterase CJ306_20385 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CJ306_20400 ENOG4105XZV Protein of unknown function (DUF3243) CJ306_20405 ENOG4108RKS Short-chain dehydrogenase reductase Sdr CJ306_20425 ENOG4105UIB (ABC) transporter CJ306_20430 ENOG4108JQ9 ABC transporter CJ306_20435 ENOG4105DIH basic membrane CJ306_20440 ENOG4105FDP GntR family transcriptional regulator CJ306_20450 ENOG4105CNU cell division protein FtsK CJ306_20460 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit CJ306_20470 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CJ306_20480 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CJ306_20485 ENOG4108S0H Dipicolinic acid synthetase, b subunit CJ306_20490 ENOG4105E35 Dipicolinate synthase subunit A CJ306_20500 ENOG4105C1V Peptidase, M16 CJ306_20520 ENOG4105DTN riboflavin biosynthesis protein ribF CJ306_20535 ENOG4105W7A Protein of unknown function (DUF503) CJ306_20545 ENOG4105VHM ribosomal protein CJ306_20550 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination CJ306_20555 ENOG4105CHV Transcription elongation factor NusA CJ306_20565 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CJ306_20570 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) CJ306_20575 ENOG4105DZP Membrane-associated zinc metalloprotease CJ306_20580 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) CJ306_20585 ENOG4105KNE Phosphatidate cytidylyltransferase CJ306_20590 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CJ306_20600 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) CJ306_20630 ENOG4108HE4 integrase family CJ306_20640 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CJ306_20645 ENOG4105C79 DNA protecting protein DprA CJ306_20650 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha CJ306_20665 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) CJ306_20690 ENOG4105VB6 UPF0109 protein CJ306_20710 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CJ306_20715 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) CJ306_20730 ENOG4105CHR reductase CJ306_20735 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CJ306_20750 ENOG4105CB5 ATP-dependent DNA helicase recG CJ306_20755 ENOG4105DP4 dak2 domain fusion protein ylov CJ306_20760 ENOG4108ZAA Alkaline-shock protein CJ306_20775 ENOG4105FJ0 thiamine CJ306_20780 ENOG4105DJV ribulose-phosphate 3-epimerase CJ306_20785 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CJ306_20790 ENOG4105D9P serine threonine protein kinase CJ306_20795 ENOG4108ZF3 Phosphatase CJ306_20800 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs CJ306_20805 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CJ306_20820 ENOG4105C25 Primosomal protein n' CJ306_20825 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase CJ306_20845 ENOG4105DSJ YicC domain protein CJ306_20855 ENOG4105F23 Fibronectin-binding protein CJ306_20865 ENOG4105DC7 peptidase M24 CJ306_20900 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) CJ306_20915 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) CJ306_20920 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain CJ306_20930 ENOG4105CD3 dihydroorotase CJ306_20950 ENOG4105C34 Pseudouridine synthase CJ306_20965 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CJ306_20975 ENOG4105DBK s4 domain protein CJ306_20980 ENOG41067XK integral membrane protein CJ306_20990 ENOG4105DFA alanine racemase domain protein CJ306_20995 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CJ306_21000 ENOG4105WR5 sporulation protein, YlmC YmxH family CJ306_21010 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CJ306_21020 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CJ306_21025 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CJ306_21035 ENOG4105D4A Cell wall formation (By similarity) CJ306_21040 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CJ306_21045 ENOG4105CNI cell division protein FtsW CJ306_21050 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) CJ306_21060 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CJ306_21065 ENOG4105CJN penicillin-binding protein CJ306_21070 ENOG4105CJN penicillin-binding protein CJ306_21085 ENOG41074B2 UPF0747 protein CJ306_21110 ENOG4105KNH Nucleic acid-binding protein CJ306_21120 ENOG41063PX domain protein CJ306_21125 ENOG4105D78 K07001 NTE family protein CJ306_21130 ENOG4105H20 Sporulation integral membrane protein YlbJ CJ306_21140 ENOG4106H78 methyltransferase CJ306_21160 ENOG4107TB6 phosphoglycerate mutase CJ306_21175 ENOG4106UY4 Inherit from COG: Scp-like extracellular CJ306_21220 ENOG4107VFP cytochrome oxidase assembly CJ306_21225 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) CJ306_21235 ENOG4105CNI cell division protein FtsW CJ306_21250 ENOG4108IAB Phoh family CJ306_21270 ENOG4105QA2 CJ306_21275 ENOG4105CI3 gtp-binding protein typa CJ306_21285 ENOG4105ECY inositol monophosphatase CJ306_21305 ENOG4105CXN decarboxylase CJ306_21355 ENOG4105CPP Dehydrogenase, E1 component CJ306_21370 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CJ306_21375 ENOG4108X4Q Hydrolase CJ306_21390 ENOG4105CN5 Metallo-Beta-Lactamase CJ306_21395 ENOG4107ZYR domain protein CJ306_21430 ENOG4108XRC Protein of unknown function (DUF458) CJ306_21440 ENOG4107IN1 Protein of unknown function (DUF1797) CJ306_21455 ENOG4105EPM Diguanylate phosphodiesterase CJ306_21460 ENOG4105K6S Short-chain dehydrogenase reductase Sdr CJ306_21480 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) CJ306_21490 ENOG4105UIN CJ306_21525 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) CJ306_21550 ENOG4108HGU Histidine kinase CJ306_21560 ENOG4105CHM Aminotransferase CJ306_21565 ENOG4105FKQ transcriptional regulator CJ306_21570 ENOG4105EG2 ABC transporter, permease CJ306_21580 ENOG4107FKK extracellular solute-binding protein family 1 CJ306_21590 ENOG4105CG3 alpha amylase, catalytic region CJ306_21635 ENOG4105CHU acetyl-coa acetyltransferase CJ306_21670 ENOG4105K7K Transcriptional regulator CJ306_21675 ENOG4105DTD Dehydrogenase CJ306_21695 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase CJ306_21720 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) CJ306_21735 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CJ306_21745 ENOG4105BZU Histidine kinase CJ306_21765 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) CJ306_21780 ENOG4105CID antiterminator CJ306_21790 ENOG4105FDP GntR family transcriptional regulator CJ306_21800 ENOG4105CE4 GlcNAc 6-P deacetylase CJ306_21840 ENOG4107ZE5 PPIases accelerate the folding of proteins CJ306_21845 ENOG4105PTM secreted protein CJ306_21850 ENOG4105J7I hydrolase CJ306_21860 ENOG4105G6R Stage v sporulation protein ae CJ306_21870 ENOG4105CZ3 stage V sporulation protein ad CJ306_21875 ENOG41090VF Stage v sporulation protein ac CJ306_21895 ENOG4105C8J )-transporter CJ306_21900 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CJ306_21910 ENOG41082AN stage II sporulation protein CJ306_21915 ENOG4105DZ1 carboxypeptidase CJ306_21925 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family CJ306_21930 ENOG4105DVE abc transporter atp-binding protein CJ306_21965 ENOG4105D7N magnesium and cobalt transport protein CorA CJ306_21990 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CJ306_22000 ENOG4105I3K Ferric uptake regulator, Fur family CJ306_22005 ENOG4105MZ9 stage II sporulation protein m CJ306_22025 ENOG4105CPC Aldo Keto reductase CJ306_22035 ENOG4105RHY Pfam:UPF0157 CJ306_22055 ENOG4107SKW Inherit from COG: Alpha beta hydrolase CJ306_22065 ENOG4105ETE Transcriptional regulator (LacI family CJ306_22070 ENOG4108YM7 Gcn5-related n-acetyltransferase CJ306_22090 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CJ306_22095 ENOG4108R6K riboflavin synthase, subunit alpha CJ306_22120 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CJ306_22125 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CJ306_22140 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CJ306_22155 ENOG4105DFD Na H antiporter CJ306_22160 ENOG4105CGH 5'-nucleotidase CJ306_22185 ENOG4105DBV ornithine carbamoyltransferase CJ306_22200 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) CJ306_22215 ENOG4108IXY short-chain dehydrogenase reductase CJ306_22220 ENOG41069FQ Metallo-beta-lactamase superfamily CJ306_22225 ENOG4105II7 pyrroline-5-carboxylate reductase CJ306_22230 ENOG4105EJQ L-serine dehydratase CJ306_22250 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) CJ306_22265 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic CJ306_22280 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CJ306_22285 ENOG4105D9U N-acetyltransferase CJ306_22300 ENOG4108VZI ErfK ybiS ycfS ynhG family protein CJ306_22305 ENOG4108QEG Membrane CJ306_22310 ENOG4105CDA abc transporter atp-binding protein CJ306_22315 ENOG4105E5Q amino acid AbC transporter CJ306_22320 ENOG4108HW3 (ABC) transporter CJ306_22330 ENOG4105G7B Protein of unknown function (DUF2992) CJ306_22355 ENOG4105C7S Dehydrogenase CJ306_22360 ENOG4105CPP Dehydrogenase, E1 component CJ306_22380 ENOG4107RDP Dehydrogenase CJ306_22395 ENOG4108JUB Transcriptional regulator CJ306_22405 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CJ306_22420 ENOG4107QQR Sporulation CJ306_22430 ENOG4105S1Z Stage IV sporulation protein B CJ306_22435 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CJ306_22440 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) CJ306_22445 ENOG4105DX0 Hemolysin A CJ306_22455 ENOG4105CTB Polyprenyl synthetase CJ306_22470 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) CJ306_22480 ENOG4108ZSR alkaline shock protein CJ306_22485 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CJ306_22510 ENOG410644B Stage III sporulation protein af CJ306_22520 ENOG4105KQ4 Stage iii sporulation protein ad CJ306_22525 ENOG4108CQH stage III sporulation protein AC CJ306_22530 ENOG4105KR5 Stage iii sporulation protein CJ306_22535 ENOG4105CD2 stage iii sporulation protein aa CJ306_22560 ENOG4105DC7 peptidase M24 CJ306_22565 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) CJ306_22575 ENOG4105CBJ Metal-dependent enzyme CJ306_22585 ENOG4107YBY Hydrolase CJ306_22615 ENOG41082GG biotin lipoate A B protein ligase CJ306_22620 ENOG4105WZW rhodanese family CJ306_22645 ENOG41080TC multidrug resistance protein CJ306_22675 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CJ306_22695 ENOG4105C0D helicase CJ306_22785 ENOG4107R6U sodium dicarboxylate symporter CJ306_22820 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CJ306_22825 ENOG4105C3R Methionine synthase CJ306_22835 ENOG4105C28 cystathionine CJ306_22840 ENOG4105C28 cystathionine CJ306_22860 ENOG4105C5X domain protein CJ306_22870 ENOG4105DKQ ROK family CJ306_22880 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase CJ306_22895 ENOG4108UTW Plays a role in the regulation of phosphate uptake CJ306_22900 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CJ306_22905 ENOG4105C8U phosphate abc transporter CJ306_22910 ENOG4105C8U phosphate abc transporter CJ306_22915 ENOG4105EXS phosphate abc transporter CJ306_22920 ENOG4107RF6 penicillin-binding protein CJ306_22930 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CJ306_22955 ENOG4105N80 Ferric uptake regulator, Fur family CJ306_22965 ENOG4105FDK ABC transporter CJ306_22970 ENOG4108JYZ YitT family CJ306_22975 ENOG41069ZM Protein of unknown function (DUF2624) CJ306_23000 ENOG4105EGD dinuclear metal center protein, YbgI family CJ306_23015 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CJ306_23020 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CJ306_23055 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) CJ306_23060 ENOG4105KG3 cytidine deaminase CJ306_23065 ENOG4107YR5 Diacylglycerol kinase CJ306_23070 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) CJ306_23075 ENOG4105CTJ Metal Dependent Phosphohydrolase CJ306_23080 ENOG4105C9A Phoh family CJ306_23090 ENOG41068P3 sporulation protein YqfC CJ306_23100 ENOG4105KTH gatB Yqey CJ306_23115 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CJ306_23120 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CJ306_23150 ENOG4105CSA Coproporphyrinogen iii oxidase CJ306_23155 ENOG4105KVH Transcriptional regulator CJ306_23180 ENOG4105TQK DNA polymerase iii, delta' subunit CJ306_23190 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 CJ306_23195 ENOG4108UK2 deaminase CJ306_23200 ENOG4105KQC Competence protein CJ306_23210 ENOG4105DXX methyltransferase CJ306_23220 ENOG4108WF2 Metal Dependent Phosphohydrolase CJ306_23230 ENOG410812S Rna-binding protein CJ306_23240 ENOG4105CQW ribosome biogenesis GTPase YqeH CJ306_23245 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase CJ306_23260 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CJ306_23280 ENOG4108TVJ Nitroreductase CJ306_23295 ENOG4105G6Z alkaline phosphatase CJ306_23300 ENOG4105KEG ribosomal-protein-alanine acetyltransferase CJ306_23305 ENOG4108MUZ hydrolase CJ306_23340 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin CJ306_23350 ENOG4105MIR Phenylalanine 4-monooxygenase CJ306_23360 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase CJ306_23400 ENOG4105S6R Iron-hydroxamate transporter permease subunit CJ306_23405 ENOG4108V5C ABC transporter CJ306_23420 ENOG4108EKI Dehydrogenase CJ306_23425 ENOG4105C28 cystathionine CJ306_23455 ENOG4107XRG penicillin-binding protein CJ306_23465 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) CJ306_23475 ENOG4105CFP Peptidase U32 CJ306_23480 ENOG4105XYU peptidase (U32 family) CJ306_23485 ENOG4108VQJ O-methyltransferase CJ306_23490 ENOG4105HHA aminodeoxychorismate lyase CJ306_23510 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CJ306_23520 ENOG4105C02 permease CJ306_23535 ENOG41060CR CJ306_23540 ENOG4105C7H Helicase, RecD TraA family CJ306_23550 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) CJ306_23555 ENOG4105C3J Cysteine desulfurase CJ306_23565 ENOG4105D1H recombination factor protein RarA CJ306_23570 ENOG4108VCI transcription factor, rsfa family CJ306_23585 ENOG4105CUZ uba thif-type nad fad binding protein CJ306_23595 ENOG4105CUT histidyl-tRNA synthetase CJ306_23605 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) CJ306_23610 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CJ306_23620 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CJ306_23625 ENOG41076HS cation diffusion facilitator family transporter CJ306_23630 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CJ306_23640 ENOG4105CKP Polysaccharide Biosynthesis Protein CJ306_23645 ENOG4108QG2 Membrane CJ306_23655 ENOG4105VIE preprotein translocase, subunit YajC CJ306_23670 ENOG41061AI Protein of unknown function (DUF2905) CJ306_23685 ENOG4108HUF Transporter CJ306_23710 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) CJ306_23715 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase CJ306_23720 ENOG4108IYU L-aspartate oxidase CJ306_23735 ENOG4108RPX mosc domain containing protein CJ306_23765 ENOG4105CQC Prephenate dehydratase CJ306_23780 ENOG4105C19 ABC transporter CJ306_23785 ENOG4105EWM Histidine kinase CJ306_23795 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control CJ306_23810 ENOG4105X36 (ribosomal) protein CJ306_23820 ENOG4105C03 ribonuclease CJ306_23835 ENOG4107QMS site-determining protein CJ306_23850 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) CJ306_23855 ENOG4105DFF Rod shape-determining protein mreb CJ306_23875 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CJ306_23880 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) CJ306_23890 ENOG41068KH stage VI sporulation protein D CJ306_23900 ENOG4105D52 delta-aminolevulinic acid dehydratase CJ306_23925 ENOG4105K56 Transcriptional regulator CJ306_23945 ENOG4108IUQ atp-dependent protease CJ306_23975 ENOG4108QCI YvbH-like oligomerisation region CJ306_24020 ENOG4105M59 Phosphodiesterase, mj0936 family CJ306_24025 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CJ306_24035 ENOG4108XJQ germination protein CJ306_24045 ENOG4108PCX Major Facilitator CJ306_24055 ENOG4105KBX Transcriptional regulator, TetR family CJ306_24065 ENOG4105PFC Transcriptional regulator CJ306_24075 ENOG4105DZC cytosine deaminase CJ306_24080 ENOG41067S9 phage shock protein C, PspC CJ306_24085 ENOG4108JCI Transcriptional regulator CJ306_24095 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CJ306_24100 ENOG4108Z40 Transcriptional regulator CJ306_24105 ENOG4105RHA ABC transporter, permease CJ306_24110 ENOG4108IUX (ABC) transporter CJ306_24115 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family CJ306_24120 ENOG4105ER2 Ompa motb domain protein CJ306_24125 ENOG4105E14 MotA TolQ exbB proton channel CJ306_24130 ENOG4108VXD carboxy-peptidase CJ306_24140 ENOG4105E33 succinate dehydrogenase CJ306_24150 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit CJ306_24160 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CJ306_24165 ENOG4105K63 Thioredoxin CJ306_24170 ENOG4105C10 Electron transfer flavoprotein CJ306_24175 ENOG4105BZJ Electron transfer flavoprotein CJ306_24180 ENOG41060WC Enoyl-CoA hydratase CJ306_24185 ENOG4107Z3H Transcriptional regulator, TetR family CJ306_24190 ENOG4105CEY Amp-dependent synthetase and ligase CJ306_24205 ENOG4105J76 Periplasmic binding protein CJ306_24210 ENOG4105S6R Iron-hydroxamate transporter permease subunit CJ306_24265 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CJ306_24280 ENOG4105DR4 Methyltransferase CJ306_24295 ENOG4105KFN sortase, SrtB family CJ306_24300 ENOG4105E0A ABC, transporter CJ306_24315 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) CJ306_24320 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) CJ306_24325 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) CJ306_24335 ENOG4105FE9 pseudouridine synthase CJ306_24350 ENOG4105DCG PHP domain protein CJ306_24395 ENOG4105C5S asparaginyl-tRNA synthetase CJ306_24400 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) CJ306_24410 ENOG4108RWN rrna methyltransferase CJ306_24440 ENOG4105C0R drug resistance transporter emrb qaca subfamily CJ306_24445 ENOG4105CW7 secretion protein, HlyD family CJ306_24450 ENOG4108JGH Tetr family transcriptional regulator CJ306_24455 ENOG4105CN9 Peptidase m42 family protein CJ306_24475 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) CJ306_24480 ENOG4105C22 threonyL-tRNA synthetase CJ306_24485 ENOG4108TDW sporulation protein YtxC CJ306_24510 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) CJ306_24520 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CJ306_24525 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) CJ306_24535 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CJ306_24540 ENOG4105C2M dna polymerase I CJ306_24545 ENOG4105BZU Histidine kinase CJ306_24550 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CJ306_24570 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CJ306_24575 ENOG4108HMX isocitrate dehydrogenase (NADP) CJ306_24580 ENOG4105BZN citrate synthase CJ306_24595 ENOG4108REF Sporulation integral membrane protein ytvi CJ306_24600 ENOG4105FS0 cytoplasmic membrane protein CJ306_24625 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family CJ306_24630 ENOG4105C6K Malic enzyme CJ306_24635 ENOG4105C0B DNA polymerase III (alpha subunit) CJ306_24640 ENOG4105VV2 CJ306_24650 ENOG4105SFS phosphoesterase RecJ domain protein CJ306_24680 ENOG4105DC7 peptidase M24 CJ306_24720 ENOG4105Z7P Acetyltransferase (GNAT) family CJ306_24725 ENOG41082W1 Cupin 2, conserved barrel domain protein CJ306_24745 ENOG4107YZX Universal stress protein CJ306_24790 ENOG4108JYZ YitT family CJ306_24810 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) CJ306_24820 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) CJ306_24825 ENOG4106F1P AAA ATPase, central domain protein CJ306_24830 ENOG4105KBJ sporulation protein ytfj CJ306_24845 ENOG4105EFZ amidohydrolase CJ306_24855 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CJ306_24880 ENOG4106KR7 LysR family Transcriptional regulator CJ306_24890 ENOG4105U5Y Transcriptional regulator CJ306_24900 ENOG4105C28 cystathionine CJ306_24960 ENOG4105EMN RNA polymerase sigma factor CJ306_24970 ENOG4108UW5 maltose o-acetyltransferase CJ306_24980 ENOG4105F1V Acetoin utilization protein CJ306_24985 ENOG4105W87 Cbs domain CJ306_24990 ENOG4105DGU Histone deacetylase CJ306_25005 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CJ306_25015 ENOG4107SNB ankyrin repeat protein YahD CJ306_25020 ENOG4105EP9 oxidoreductase CJ306_25050 ENOG4105ETE Transcriptional regulator (LacI family CJ306_25065 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase CJ306_25085 ENOG4105C88 aminopeptidase CJ306_25145 ENOG4108VDD TRNA binding domain protein CJ306_25175 ENOG4105C8F Beta-lactamase domain protein CJ306_25190 ENOG4108V15 phosphotransferase enzyme family CJ306_25195 ENOG4108IUM Glycogen debranching enzyme CJ306_25210 ENOG4107QSE Dipeptidase CJ306_25215 ENOG4105YW5 deoR family transcriptional regulator CJ306_25230 ENOG4105CBX hi0933 family CJ306_25275 ENOG4108VJ1 Transcriptional regulator (CarD family CJ306_25280 ENOG4107EXU Short-chain dehydrogenase reductase Sdr CJ306_25285 ENOG4105CSC Glucose uptake protein CJ306_25300 ENOG4108ZAF Molybdopterin CJ306_25305 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein CJ306_25310 ENOG4105CVM Molybdenum cofactor synthesis domain protein CJ306_25320 ENOG4105D06 uba thif-type nad fad binding protein CJ306_25325 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CJ306_25350 ENOG41085GJ domain protein CJ306_25360 ENOG4105DWV Homoserine O-trans-acetylase CJ306_25370 ENOG4108B31 Spore germination protein CJ306_25395 ENOG4105C8T Leucyl-tRNA synthetase CJ306_25400 ENOG410605W Major Facilitator CJ306_25405 ENOG4107S91 Sodium hydrogen exchanger CJ306_25410 ENOG4105NCW Trka-c domain protein CJ306_25425 ENOG4105C19 ABC transporter CJ306_25445 ENOG4105N5T Radical SAM Protein CJ306_25455 ENOG4105CIG ABC transporter CJ306_25495 ENOG4105E8V Alpha Beta Hydrolase Fold protein CJ306_25500 ENOG4108Z0R Transferase CJ306_25505 ENOG4105YVM Phosphoesterase, PA-phosphatase related CJ306_25510 ENOG4105BZF Glycosyl transferase (Group 1 CJ306_25520 ENOG4105EPU Molybdenum cofactor synthesis domain protein CJ306_25580 ENOG4107XGZ Hydrolase CJ306_25585 ENOG4105E98 transcriptional regulator DeoR family CJ306_25600 ENOG4105BZU Histidine kinase CJ306_25605 ENOG4105BZU Histidine kinase CJ306_25610 ENOG4105CH6 catalase CJ306_25620 ENOG4107S9D Alpha beta hydrolase CJ306_25625 ENOG4107T7U Sulfatase CJ306_25645 ENOG4105D2X ABC transporter substrate-binding protein CJ306_25655 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component CJ306_25725 ENOG4108V2W Carbonate dehydratase CJ306_25730 ENOG4105D7V transposase CJ306_25735 ENOG4105C4M (Ubiquinol oxidase) subunit I CJ306_25740 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CJ306_25780 ENOG41087YS Phage shock protein A CJ306_25810 ENOG4105BZU Histidine kinase CJ306_25815 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CJ306_25840 ENOG4108UGV hypoxanthine phosphoribosyltransferase CJ306_25845 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) CJ306_25890 ENOG4105C19 ABC transporter CJ306_25915 ENOG4107ZTW SNARE associated Golgi CJ306_25930 ENOG4105C19 ABC transporter CJ306_25935 ENOG41086D8 Transcriptional regulator CJ306_25945 ENOG4105CJ1 ABC, transporter CJ306_25955 ENOG41082BM Transcriptional regulator, arsr family CJ306_25995 ENOG4105C6Z Gluconate CJ306_26000 ENOG4105FDP GntR family transcriptional regulator CJ306_26020 ENOG41069H0 dihydroorotase EC 3.5.2.3 CJ306_26040 ENOG4105DTQ mandelate racemase muconate lactonizing CJ306_26045 ENOG4105CEY Amp-dependent synthetase and ligase CJ306_26050 ENOG4108IPT Naphthoate synthase CJ306_26055 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) CJ306_26060 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) CJ306_26065 ENOG4105E4F Isochorismate synthase CJ306_26070 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CJ306_26080 ENOG4105VEQ Cold shock protein CJ306_26120 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) CJ306_26135 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin CJ306_26240 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CJ306_26280 ENOG4105KT7 mgtC SapB transporter CJ306_26285 ENOG4107PBV potassium channel CJ306_26305 ENOG4105WG9 Conserved Protein CJ306_26315 ENOG4105CHM Aminotransferase CJ306_26320 ENOG4108ZB6 transcriptional regulator AsnC family CJ306_26325 ENOG4105C5I Dehydrogenase CJ306_26330 ENOG4108MUZ hydrolase CJ306_26340 ENOG4105C87 Aminotransferase class I and II CJ306_26350 ENOG4105Y38 Kinase-associated protein B CJ306_26360 ENOG4107R3E Citrate transporter CJ306_26380 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) CJ306_26385 ENOG4105KA0 thioesterase Superfamily protein CJ306_26405 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CJ306_26430 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) CJ306_26435 ENOG4106YN8 Prenyltransferase CJ306_26445 ENOG41069ER domain protein CJ306_26460 ENOG4105CEP NADH dehydrogenase CJ306_26490 ENOG4105EWC Purine nucleoside phosphorylase CJ306_26510 ENOG4108YX9 iron--sulfur cluster insertion protein erpA CJ306_26535 ENOG4108JJA ABC, transporter CJ306_26540 ENOG4105C4B ABC transporter, permease CJ306_26545 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA CJ306_26595 ENOG41083MR nifu domain-containing protein CJ306_26615 ENOG4108W5N phosphatidylglycerophosphatase a CJ306_26630 ENOG4105DYS nad(p)h dehydrogenase (quinone) CJ306_26640 ENOG4105D4U had-superfamily hydrolase, subfamily iia CJ306_26655 ENOG4105CBT Fructose-1,6-bisphosphatase CJ306_26680 ENOG4105MMD transcriptional regulator CJ306_26685 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) CJ306_26690 ENOG4107TXC Transcriptional regulator CJ306_26695 ENOG41090T1 Membrane CJ306_26725 ENOG4105FAA peptidase M23 CJ306_26730 ENOG4108YTE sporulation protein YunB CJ306_26735 ENOG4105KZD Domain of unknown function (DUF1805) CJ306_26740 ENOG4107R8B 5'-nucleotidase CJ306_26745 ENOG4105DIW FeS assembly protein SUFB CJ306_26750 ENOG4108UNV SUF system FeS assembly protein, NifU family CJ306_26755 ENOG4105C9B Cysteine desulfurase CJ306_26760 ENOG4105JRK feS assembly protein SufD CJ306_26765 ENOG4105C3K feS assembly ATPase SufC CJ306_26770 ENOG4105D01 (LipO)protein CJ306_26775 ENOG4105D01 (LipO)protein CJ306_26780 ENOG4108UMI ABC transporter, permease CJ306_26820 ENOG41080E8 Transcriptional regulator, Spx MgsR family CJ306_26840 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CJ306_26870 ENOG4108W8B Beta-lactamase domain protein CJ306_26875 ENOG4105C1G acyl-Coa dehydrogenase CJ306_26885 ENOG4105CHU acetyl-coa acetyltransferase CJ306_26905 ENOG4105DZ1 carboxypeptidase CJ306_26925 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer CJ306_26940 ENOG4108SUT Major Facilitator Superfamily CJ306_26945 ENOG4107R7I amino acid CJ306_26965 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CJ306_26975 ENOG4107AYK membrAne CJ306_27015 ENOG4107ZTW SNARE associated Golgi CJ306_27025 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein CJ306_27030 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CJ306_27035 ENOG4105BZU Histidine kinase CJ306_27050 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) CJ306_27065 ENOG4105C8Q Methyl-accepting chemotaxis CJ306_27070 ENOG4105VG1 fes assembly suf system protein CJ306_27075 ENOG4105D4Y metalloprotease CJ306_27095 ENOG4107S91 Sodium hydrogen exchanger CJ306_27100 ENOG4105NCW Trka-c domain protein CJ306_27120 ENOG4108RMU ferritin dps family protein CJ306_27135 ENOG4108URH decarboxylase CJ306_27145 ENOG41090A1 ferritin CJ306_27150 ENOG4105DHF Membrane CJ306_27155 ENOG4105D9N nucleoside CJ306_27160 ENOG4105D9N nucleoside CJ306_27175 ENOG4108RYK Nad-dependent epimerase dehydratase CJ306_27195 ENOG4105CV8 reductase CJ306_27200 ENOG4105F27 Major Facilitator CJ306_27205 ENOG4105KVH Transcriptional regulator CJ306_27220 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CJ306_27225 ENOG4105D4A Cell wall formation (By similarity) CJ306_27245 ENOG4105WMR Protein CrcB homolog CJ306_27250 ENOG4105WMR Protein CrcB homolog CJ306_27270 ENOG4105C5H ABC transporter CJ306_27275 ENOG4108MK9 spermidine N(1)-acetyltransferase CJ306_27280 ENOG4108VY7 phosphate-starvation-inducible protein PsiE CJ306_27315 ENOG4108IPW abc transporter atp-binding protein CJ306_27320 ENOG4105CM4 permease protein CJ306_27350 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CJ306_27360 ENOG4105XZU Preprotein translocase, subunit SecG CJ306_27365 ENOG41067MG lrgb family CJ306_27385 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CJ306_27415 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CJ306_27425 ENOG4105RHA ABC transporter, permease CJ306_27430 ENOG4108IUX (ABC) transporter CJ306_27435 ENOG4105BZU Histidine kinase CJ306_27440 ENOG4108W5X Transcriptional Regulator, LuxR family CJ306_27460 ENOG41090VF Stage v sporulation protein ac CJ306_27465 ENOG4105CZ3 stage V sporulation protein ad CJ306_27480 ENOG4108QY0 Membrane CJ306_27485 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CJ306_27490 ENOG4105KRI phosphocarrier protein (HPr CJ306_27500 ENOG4105CHW UPF0052 protein CJ306_27505 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) CJ306_27510 ENOG4108Z4K mutator MutT protein CJ306_27520 ENOG4105C3M thioredoxin reductase CJ306_27530 ENOG4108S4C acetyltransferase CJ306_27540 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) CJ306_27550 ENOG41086DT Membrane protein of unknown function CJ306_27555 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CJ306_27560 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) CJ306_27575 ENOG4107TXC Transcriptional regulator CJ306_27590 ENOG4105HMI Membrane CJ306_27595 ENOG4105DUM transcriptional regulator, lysR family CJ306_27605 ENOG4108WS4 fmn reductase CJ306_27620 ENOG4105BZ1 (ABC) transporter CJ306_27635 ENOG4105CN1 protease CJ306_27640 ENOG4105CRP Part of the ABC transporter FtsEX involved in CJ306_27645 ENOG4105CAK Cell division ATP-binding protein ftsE CJ306_27665 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) CJ306_27685 ENOG4108RDQ ABC transporter CJ306_27715 ENOG4105MS2 ribosomal subunit Interface protein CJ306_27720 ENOG4105VEQ Cold shock protein CJ306_27725 ENOG41081UC Inherit from COG: Competence protein CJ306_27740 ENOG4105KVH Transcriptional regulator CJ306_27750 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CJ306_27755 ENOG4108KGH TRANSCRIPTIONal CJ306_27760 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CJ306_27765 ENOG4105C6Y Udp-glucose 6-dehydrogenase CJ306_27770 ENOG4105ESV Glycosyl transferase, family 4 CJ306_27780 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CJ306_27800 ENOG4105F8D glycoside hydrolase family 4 CJ306_27805 ENOG4105VCP PTS System CJ306_27810 ENOG4105CK1 PTS System CJ306_27820 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) CJ306_27830 ENOG4105VCP PTS System CJ306_27840 ENOG4105VZJ PTS System CJ306_27860 ENOG4105ECB domain protein CJ306_27865 ENOG4107RSM transcriptional regulator CJ306_27920 ENOG4105DAA L-lactate CJ306_27930 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) CJ306_27945 ENOG4105E0M Sulfatase CJ306_27975 ENOG4107R8N Glycosyl transferase, family 2 CJ306_27985 ENOG4105C94 Transporter CJ306_27995 ENOG41069ER domain protein CJ306_28020 ENOG4105KBK Zinc finger, swim domain protein CJ306_28025 ENOG4105C0D helicase CJ306_28055 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CJ306_28065 ENOG4107RBB ABC transporter, permease CJ306_28070 ENOG4105C19 ABC transporter CJ306_28090 ENOG4105CXY transporter CJ306_28105 ENOG4105BZU Histidine kinase CJ306_28110 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CJ306_28115 ENOG4105CMR udp-glucose 4-epimerase CJ306_28125 ENOG4108KGH TRANSCRIPTIONal CJ306_28140 ENOG4107QRS glycosyltransferase group 2 family protein CJ306_28145 ENOG4107T8Q Glycosyl transferase (Group 1 CJ306_28155 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) CJ306_28160 ENOG4105CPF Cell wall formation (By similarity) CJ306_28165 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CJ306_28175 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CJ306_28180 ENOG4108RB3 Capsular polysaccharide biosynthesis protein CJ306_28185 ENOG4107YJ4 chain length determinant protein CJ306_28190 ENOG4105HTX biosynthesis protein CJ306_28195 ENOG4107YJ4 chain length determinant protein CJ306_28210 ENOG4105MT0 Sporulation transcriptional regulator spoiiid CJ306_28220 ENOG4105FRN stage II sporulation protein CJ306_28235 ENOG4105DY9 regulatoR CJ306_28255 ENOG4106778 Protein of unknown function (DUF1146) CJ306_28260 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CJ306_28265 ENOG4105C8S subunit m CJ306_28270 ENOG4105D65 subunit l CJ306_28295 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CJ306_28300 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CJ306_28310 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CJ306_28315 ENOG4105BZU Histidine kinase CJ306_28375 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) CJ306_28380 ENOG41062M3 atp synthase CJ306_28400 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) CJ306_28405 ENOG4108UIC UPF0340 protein CJ306_28410 ENOG4108YZG isomerase CJ306_28430 ENOG4108VGI doxx family CJ306_28435 ENOG4107XC4 flavin reductase domain protein, FMN-binding CJ306_28455 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CJ306_28465 ENOG4108ZXQ stage ii sporulation protein r CJ306_28470 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CJ306_28475 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) CJ306_28485 ENOG4107104 thymidine kinase CJ306_28495 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) CJ306_28505 ENOG4105CBT Fructose-1,6-bisphosphatase CJ306_28515 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CJ306_28535 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) CJ306_28550 ENOG4105C1G acyl-Coa dehydrogenase CJ306_28555 ENOG4105C1G acyl-Coa dehydrogenase CJ306_28560 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CJ306_28570 ENOG4105DF6 Fe-S oxidoreductase CJ306_28590 ENOG4105BZU Histidine kinase CJ306_28605 ENOG4105D4Y metalloprotease CJ306_28615 ENOG4105BZU Histidine kinase CJ306_28620 ENOG4105KCT ABC transporter CJ306_28625 ENOG4108M15 ABC transporter CJ306_28630 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) CJ306_28645 ENOG4105IIU Aminopeptidase CJ306_28665 ENOG4105DU6 RNA polymerase CJ306_28680 ENOG410684U Domain of unknown function (DUF1934) CJ306_28700 ENOG4105CYW agmatinase CJ306_28710 ENOG4105DXB Major Facilitator superfamily CJ306_28715 ENOG4107SWG transcriptional regulator MERR family CJ306_28720 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CJ306_28725 ENOG4105BZ4 penicillin-binding protein CJ306_28730 ENOG4108XFG YwhD family CJ306_28735 ENOG4108Z4T Peptidase M50 CJ306_28740 ENOG41069HH 4-oxalocrotonate tautomerase CJ306_28745 ENOG4105DCI Phosphohydrolase CJ306_28750 ENOG4108MES Periplasmic binding protein CJ306_28755 ENOG4105E0A ABC, transporter CJ306_28760 ENOG4105EHG Permease protein CJ306_28765 ENOG4105DQ5 transport system permease protein CJ306_28775 ENOG4108VCI transcription factor, rsfa family CJ306_28780 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) CJ306_28785 ENOG4108IJ2 phosphate acetyltransferase CJ306_28790 ENOG4107UEZ chlorite dismutase CJ306_28800 ENOG4108VKI Cell wall hydrolase CJ306_28820 ENOG4107SVH Potassium channel protein CJ306_28830 ENOG410667J hydrolase CJ306_28835 ENOG4105VCH membrane CJ306_28845 ENOG4108TU7 Inherit from COG: (ABC) transporter CJ306_28850 ENOG4105CJ1 ABC, transporter CJ306_28855 ENOG41090WU lipolytic protein G-D-S-L family CJ306_28870 ENOG4105D6E homoserine dehydrogenase CJ306_28895 ENOG4108Y4K DNA-binding transcriptional activator CJ306_28905 ENOG4105WH1 Two component transcriptional regulator luxr family CJ306_28910 ENOG4105BZU Histidine kinase CJ306_28915 ENOG4105DWF phosphomethylpyrimidine kinase CJ306_28920 ENOG4105BZU Histidine kinase CJ306_28925 ENOG4105VCD cytoplasmic protein CJ306_28930 ENOG4105D22 carbon starvation protein CJ306_28935 ENOG4105DY9 regulatoR CJ306_28940 ENOG41079KZ Major Facilitator Superfamily CJ306_28955 ENOG4105CG5 Glycosyl transferase (Group 1 CJ306_28965 ENOG4105EN6 Membrane CJ306_28970 ENOG4106YBV Methyl-accepting chemotaxis CJ306_28980 ENOG4108S4H thioesterase Superfamily protein CJ306_28985 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) CJ306_28995 ENOG4105K64 Glycosyl transferase, family 2 CJ306_29005 ENOG4105EJV Membrane CJ306_29010 ENOG4105CKK Glycosyl transferase, family 2 CJ306_29015 ENOG4105C5H ABC transporter CJ306_29020 ENOG41067SE Tetr family transcriptional regulator CJ306_29030 ENOG4105E0X reductase CJ306_29035 ENOG4106F5Q Membrane CJ306_29050 ENOG4108NEV two component transcriptional regulator, LytTR family CJ306_29060 ENOG4107RGD Major Facilitator superfamily CJ306_29080 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CJ306_29090 ENOG4105IW1 AmiS UreI transporter CJ306_29100 ENOG4105CMR udp-glucose 4-epimerase CJ306_29105 ENOG4108UT2 hemolysin iii CJ306_29115 ENOG4105C1J atp-dependent rna helicase CJ306_29120 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) CJ306_29125 ENOG4105DPN Oligoendopeptidase f CJ306_29135 ENOG4105BZU Histidine kinase CJ306_29140 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) CJ306_29150 ENOG4105C0H protease CJ306_29155 ENOG4105Q2H domain protein CJ306_29170 ENOG4105BZU Histidine kinase CJ306_29175 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CJ306_29200 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis CJ306_29205 ENOG4105CDU Replicative dna helicase CJ306_29215 ENOG4105BZR domain protein CJ306_29220 ENOG4108XMW Membrane CJ306_29230 ENOG4108UUM single-stranded DNA-binding protein CJ306_29240 ENOG4105C3G gtp-binding protein CJ306_29245 ENOG4105VDK protein, conserved in bacteria CJ306_29250 ENOG4105D8X mechanosensitive ion channel CJ306_29255 ENOG4108ZDA Sporulation protein YyaC CJ306_29260 ENOG4105FA0 parb-like partition protein CJ306_29265 ENOG4107QJE Chromosome Partitioning Protein CJ306_29280 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) CJ306_29285 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) CJ306_29295 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CJ306_29560 ENOG4107UGY Proline imino-peptidase CJ306_29580 ENOG4105CKK Glycosyl transferase, family 2 CJ306_29600 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase CJ306_29610 ENOG4108MEK Metal-binding protein YodA CJ306_29650 ENOG4105EKQ RNA-directed DNA polymerase CJ306_29730 ENOG4105DHF Membrane CJ306_29765 ENOG4108NGU Transcriptional regulator CJ306_29820 ENOG4105D3R alkyl hydroperoxide reductase CJ306_29825 ENOG4108IQI permease CJ306_29840 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein CJ306_29845 ENOG4105KVH Transcriptional regulator CJ306_29850 ENOG4108UW5 maltose o-acetyltransferase CJ306_29925 ENOG4108K8S endonuclease I CJ306_29945 ENOG4105D7V transposase CJ306_29950 ENOG4105CHR reductase CJ306_29985 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CJ306_30005 ENOG4105DVH amino acid CJ306_30020 ENOG4105EJQ L-serine dehydratase CJ306_30025 ENOG4105C44 Serine transporter CJ306_30040 ENOG4108JGH Tetr family transcriptional regulator CJ306_30045 ENOG4105EQ0 Major Facilitator superfamily CJ306_30055 ENOG4105CVK Glutamate decarboxylase CJ306_30065 ENOG4107QHE Choloylglycine hydrolase CJ306_30070 ENOG4105D7V transposase CJ306_30090 ENOG4105DRR Transcriptional regulator, GntR family CJ306_30105 ENOG410829K Lysine exporter protein (Lyse ygga) CJ306_30115 ENOG4105FQP Beta-lactamase CJ306_30120 ENOG4105CNI cell division protein FtsW CJ306_30125 ENOG4105CJW magnesium transporter CJ306_30135 ENOG4105F27 Major Facilitator CJ306_30140 ENOG4105GZI Transcriptional regulator CJ306_30180 ENOG4108E1C hydrolase CJ306_30215 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) CJ306_30255 ENOG4107TPS domain protein CJ306_30260 ENOG4105CEP NADH dehydrogenase CJ306_30295 ENOG4105D7V transposase CJ306_30305 ENOG4108M1A Chitin-binding protein CJ306_30335 ENOG4105D7V transposase CJ306_30400 ENOG4107EXU Short-chain dehydrogenase reductase Sdr CJ306_30410 ENOG4105BZ1 (ABC) transporter CJ306_30415 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CJ306_30425 ENOG4105CZV ABC transporter CJ306_30480 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CJ306_30485 ENOG4107VEG TrkA-N domain protein CJ306_30495 ENOG4105BZU Histidine kinase CJ306_30525 ENOG4105BZ1 (ABC) transporter CJ306_30545 ENOG41067FT ParB-like nuclease domain CJ306_30590 ENOG4105IBP Cyclic peptide transporter CJ306_30595 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) CJ306_30600 ENOG4105C0W non-ribosomal peptide synthetase CJ306_30615 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) CJ306_30620 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CJ306_30635 ENOG4105C1G acyl-Coa dehydrogenase CJ306_30655 ENOG4105C0W non-ribosomal peptide synthetase CJ306_30655 ENOG4105C0W non-ribosomal peptide synthetase CJ306_30680 ENOG4107SET aldo keto reductase CJ306_30715 ENOG4108UT6 Transferase hexapeptide repeat containing protein CJ306_30725 ENOG4105K64 Glycosyl transferase, family 2 CJ306_30730 ENOG4105E39 Enoyl-CoA hydratase CJ306_30765 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) CJ306_30770 ENOG4105C4R Atp-dependent dna helicase CJ306_30840 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 CJ306_30945 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CJ306_30965 ENOG4105K70 DNA-binding protein CJ306_30985 ENOG4107JM4 Tetratricopeptide repeat CJ306_30995 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CJ306_31070 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin CJ306_31080 ENOG4108XG2 Histidine kinase CJ306_31085 ENOG4105CAQ asparagine synthetase CJ306_31095 ENOG4108RZE Tetr family transcriptional regulator CJ306_31100 ENOG4107VMI polysaccharide deacetylase CJ306_31110 ENOG4105BZC d-serine deaminase CJ306_31120 ENOG4108IMY Transcriptional regulator CJ306_31135 ENOG4105D7V transposase CJ306_31160 ENOG4108IBT Inherit from COG: transposase CJ306_31175 ENOG4108IBT Inherit from COG: transposase CJ306_31180 ENOG4105D7V transposase CJ306_31265 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CJ306_31280 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase CJ306_31285 ENOG4105DR5 peptidase CJ306_31320 ENOG4108SHJ s-layer protein CJ306_31350 ENOG4105IIU Aminopeptidase CJ306_31460 ENOG4108WZA zeta toxin CJ306_31465 ENOG4105M6F mutator MutT protein CJ306_31470 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) CJ306_31480 ENOG4107JM4 Tetratricopeptide repeat CJ306_31680 ENOG4105CNU cell division protein FtsK