locus-tag class description WR52_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) WR52_00015 ENOG410848D S4 domain protein YaaA WR52_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) WR52_00075 ENOG4105FA2 dna polymerase iii WR52_00080 ENOG4105MA4 psp1 domain protein WR52_00090 ENOG41060K3 Methyltransferase WR52_00100 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) WR52_00105 ENOG4105KRN Transcriptional regulator, abrb family WR52_00110 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) WR52_00115 ENOG4105F8V Hydrolase, tatD family WR52_00120 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) WR52_00130 ENOG4105XFA sporulation peptidase YabG WR52_00135 ENOG4105W42 Veg protein WR52_00150 ENOG4105DFT pur operon repressor WR52_00155 ENOG4105KME endoribonuclease L-psp WR52_00170 ENOG4105C5T Phosphoribosyl pyrophosphate synthase WR52_00175 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) WR52_00185 ENOG4108JA2 transcriptioN-repair coupling factor WR52_00190 ENOG4108M14 stage v sporulation protein t WR52_00200 ENOG4108IY2 MazG family WR52_00205 ENOG41082I2 s4 domain protein WR52_00210 ENOG4105VYY sporulation protein yabp WR52_00225 ENOG41060GV RNA binding s1 domain protein WR52_00245 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) WR52_00250 ENOG4108UGV hypoxanthine phosphoribosyltransferase WR52_00255 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) WR52_00270 ENOG4105C6T cysteine synthase WR52_00275 ENOG4105CRQ synthase (Component I) WR52_00280 ENOG4105DDQ anthranilate synthase WR52_00285 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 WR52_00290 ENOG4105EEI dihydropteroate synthase WR52_00295 ENOG4105KRF dihydroneopterin aldolase WR52_00300 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase WR52_00310 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) WR52_00400 ENOG4108Z0C Uvrb UvrC protein WR52_00415 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) WR52_00425 ENOG4105CTP PilT protein domain protein WR52_00430 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) WR52_00445 ENOG4105D7W serine acetyltransferase WR52_00460 ENOG4105C2N RNA methyltransferase TrmH family group 3 WR52_00465 ENOG4105M0M Tetracycline resistance protein WR52_00470 ENOG4105QIV RNA polymerase WR52_00485 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) WR52_00510 ENOG4107Y49 methyltransferase WR52_00525 ENOG4105XPM ribosomal protein WR52_00630 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) WR52_00655 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) WR52_00665 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) WR52_00675 ENOG41067V7 50S ribosomal protein L36 WR52_00700 ENOG4108JJB ABC transporter WR52_00705 ENOG4108JJB ABC transporter WR52_00710 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) WR52_00715 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) WR52_00740 ENOG4105D1F ATP-binding protein WR52_00755 ENOG4108NMV polysaccharide deacetylase WR52_00835 ENOG4105C8B TIGR00159 family WR52_00840 ENOG4107U5W ybbr family WR52_00880 ENOG4108PSK reductase WR52_00885 ENOG4108UMI ABC transporter, permease WR52_00890 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) WR52_00895 ENOG4105D01 (LipO)protein WR52_00900 ENOG4105CB2 alcohol dehydrogenase WR52_00910 ENOG4105IQ5 FAD linked oxidase domain protein WR52_00925 ENOG4105C2C drug resistance transporter, Bcr CflA WR52_00955 ENOG4108J59 Extracellular solute-binding protein, family 5 WR52_00960 ENOG4108J59 Extracellular solute-binding protein, family 5 WR52_00985 ENOG4105E0C molybdate abc transporter WR52_00990 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein WR52_00995 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family WR52_01010 ENOG4105EGI Transcriptional regulator WR52_01030 ENOG4105F6E Acyl-transferase WR52_01050 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) WR52_01070 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) WR52_01095 ENOG4105C5H ABC transporter WR52_01105 ENOG4105DEF Extracellular solute-binding protein, family 5 WR52_01115 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component WR52_01120 ENOG4105C3U ABC transporter WR52_01125 ENOG4108JQ7 (ABC) transporter WR52_01130 ENOG410667J hydrolase WR52_01160 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase WR52_01165 ENOG4105ERH Fumarylacetoacetate hydrolase WR52_01175 ENOG4105CUB amino acid WR52_01180 ENOG4108SC4 )-transporter WR52_01185 ENOG4105CPF Cell wall formation (By similarity) WR52_01190 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) WR52_01215 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein WR52_01220 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) WR52_01230 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) WR52_01335 ENOG4105K8N protein family UPF0079, ATPase WR52_01340 ENOG41072GX Peptidase M22 Glycoprotease WR52_01345 ENOG410801F ribosomal-protein-alanine acetyltransferase WR52_01350 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) WR52_01355 ENOG4105C5H ABC transporter WR52_01370 ENOG4108TYN CAAX amino terminal protease family protein WR52_01385 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) WR52_01390 ENOG4105C7N Xanthine uracil vitamin C permease WR52_01400 ENOG4105BZU Histidine kinase WR52_01425 ENOG4107ZXU DSBA oxidoreductase WR52_01475 ENOG4108SHN Glycosyl transferase, family 2 WR52_01515 ENOG4105DPZ Two component transcriptional regulator (Winged helix family WR52_01535 ENOG4105SX7 Transporter WR52_01565 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) WR52_01570 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit WR52_01575 ENOG4105C83 adenylosuccinate lyase WR52_01585 ENOG4105VR9 phosphoribosylformylglycinamidine synthase WR52_01610 ENOG4108V3E phosphoribosylglycinamide formyltransferase WR52_01615 ENOG4105DC1 bifunctional purine biosynthesis protein purh WR52_01620 ENOG4105C12 Phosphoribosylglycinamide synthetase WR52_01650 ENOG4105C4R Atp-dependent dna helicase WR52_01655 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) WR52_01675 ENOG4108W2Y isochorismatase WR52_01680 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) WR52_01685 ENOG4108UMI ABC transporter, permease WR52_01690 ENOG4105D01 (LipO)protein WR52_01710 ENOG410834F Transcriptional regulator WR52_01715 ENOG4107I77 yiaA/B two helix domain WR52_01725 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) WR52_01735 ENOG4105CBD Diacylglycerol kinase WR52_01740 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) WR52_01745 ENOG4108JPW Aminotransferase WR52_01755 ENOG4105C26 Dehydrogenase WR52_01760 ENOG4105KPY Small multidrug resistance protein WR52_01785 ENOG4105D9N nucleoside WR52_01790 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) WR52_01800 ENOG4108W15 Protein of unknown function (DUF1456) WR52_01815 ENOG4105DTQ mandelate racemase muconate lactonizing WR52_01825 ENOG4105DFD Na H antiporter WR52_01850 ENOG4105D3R alkyl hydroperoxide reductase WR52_01855 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) WR52_01860 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) WR52_01865 ENOG4107W7X Aldolase WR52_01870 ENOG4105EHG Permease protein WR52_01875 ENOG4105DQ5 transport system permease protein WR52_01880 ENOG4108V5C ABC transporter WR52_01890 ENOG4105CAY ferredoxin--nadp reductase WR52_01910 ENOG4106UIA WR52_01915 ENOG4106UIA WR52_01930 ENOG4105BZU Histidine kinase WR52_01950 ENOG410756H nucleotidyltransferase WR52_01965 ENOG4105D2S major facilitator superfamily WR52_01980 ENOG4105E5Q amino acid AbC transporter WR52_01985 ENOG4105EAB amino acid AbC transporter WR52_01995 ENOG4105C8Q Methyl-accepting chemotaxis WR52_02010 ENOG4105DBV ornithine carbamoyltransferase WR52_02020 ENOG4105C5B carbamate kinase WR52_02025 ENOG4108W63 CRP FNR family transcriptional regulator WR52_02035 ENOG4105DNP FAD linked oxidase domain protein WR52_02045 ENOG4105CI1 PTS System WR52_02060 ENOG4105C9U ATP-dependent DNA helicase RecQ WR52_02075 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter WR52_02095 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component WR52_02100 ENOG4105D2X ABC transporter substrate-binding protein WR52_02135 ENOG41062JF Transcriptional regulator WR52_02150 ENOG4105DEU major facilitator superfamily WR52_02165 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) WR52_02180 ENOG4108N0M stress protein WR52_02185 ENOG4106FN3 tellurium resistance protein WR52_02190 ENOG4106FN3 tellurium resistance protein WR52_02195 ENOG4107TS3 membrane protein, TerC WR52_02200 ENOG4108TTB tellurium resistance protein WR52_02215 ENOG41068PA UPF0435 protein WR52_02220 ENOG4105KJF protein tyrosine phosphatase WR52_02230 ENOG4107U9T Pfam:Ribonuclease_BN WR52_02235 ENOG4105C59 p-type ATPase WR52_02240 ENOG4108IPJ Membrane WR52_02260 ENOG4107ZTW SNARE associated Golgi WR52_02275 ENOG410606W general stress protein WR52_02280 ENOG4105UPD Calcium Proton WR52_02315 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) WR52_02320 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) WR52_02330 ENOG4108JUB Transcriptional regulator WR52_02340 ENOG4108IQI permease WR52_02385 ENOG4108A04 Beta-lactamase WR52_02400 ENOG4107R51 Glycosyl transferase, family 2 WR52_02405 ENOG4107QQG Dehydrogenase WR52_02410 ENOG4105C3I Nad-dependent epimerase dehydratase WR52_02415 ENOG4105C3Q Glycosyl transferase, family 2 WR52_02430 ENOG4105F1A Pyruvate formate-lyase WR52_02435 ENOG4108QBV Monogalactosyldiacylglycerol synthase WR52_02450 ENOG4105CI2 imidazolone-5-propionate hydrolase WR52_02455 ENOG4105ECP epimerase WR52_02485 ENOG41067AE Membrane-bound metal-dependent hydrolase WR52_02490 ENOG4105CEN a g-specific adenine glycosylase WR52_02495 ENOG4106BXE WR52_02515 ENOG4105BZ1 (ABC) transporter WR52_02520 ENOG4107NBY Membrane WR52_02525 ENOG4105CBC glutamate synthase WR52_02535 ENOG4108IUW ABC transporter WR52_02555 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen WR52_02560 ENOG4105G5W regulator Fur family WR52_02670 ENOG4105CDY transcriptional regulatory protein WR52_02680 ENOG4108JQC penicillin-binding protein 1A WR52_02685 ENOG4108R9S DSBA oxidoreductase WR52_02695 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) WR52_02705 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) WR52_02710 ENOG4105BZU Histidine kinase WR52_02720 ENOG4105CYN Serine protein kinase WR52_02740 ENOG4105C94 Transporter WR52_02755 ENOG4105DZ6 Band 7 protein WR52_02765 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism WR52_02770 ENOG4108V9W transcriptional regulatory protein WR52_02775 ENOG4105D4T Citrate transporter WR52_02800 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator WR52_02805 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) WR52_02810 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component WR52_02815 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component WR52_02820 ENOG4105BZ7 extracellular solute-binding protein family 1 WR52_02825 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) WR52_02830 ENOG4108STX response regulator WR52_02835 ENOG4105US7 Histidine kinase WR52_02860 ENOG4108MRH transcriptional regulatory protein WR52_02870 ENOG4105C6K Malic enzyme WR52_02880 ENOG4108UZ3 Transporter WR52_02885 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WR52_02895 ENOG4105BZU Histidine kinase WR52_02915 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) WR52_02920 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) WR52_02925 ENOG4108JB9 formate dehydrogenase WR52_02945 ENOG4105CUB amino acid WR52_02955 ENOG4105C59 p-type ATPase WR52_02965 ENOG4105DQ6 Transposase WR52_02970 ENOG4105DAP Nicotinate phosphoribosyltransferase WR52_03000 ENOG41073R8 VanW family WR52_03005 ENOG4108KGH TRANSCRIPTIONal WR52_03010 ENOG4105D9N nucleoside WR52_03015 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase WR52_03020 ENOG4105C37 (CBS) domain WR52_03025 ENOG4108IJ0 Aspartate ammonia-lyase WR52_03030 ENOG4105DAA L-lactate WR52_03045 ENOG4105DUX Transporter WR52_03050 ENOG4108MES Periplasmic binding protein WR52_03055 ENOG4105DQ5 transport system permease protein WR52_03060 ENOG4108IHU transport system permease protein WR52_03065 ENOG4105E0A ABC, transporter WR52_03070 ENOG4105DMQ Methyltransferase WR52_03080 ENOG4105EXW epimerase dehydratase WR52_03090 ENOG4107T89 von Willebrand factor, type A WR52_03095 ENOG4105GMT ATPase associated with various cellular activities aaa_5 WR52_03100 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) WR52_03110 ENOG4105BZU Histidine kinase WR52_03115 ENOG4105D5Q Arginine ornithine antiporter WR52_03120 ENOG4107414 GntR family transcriptional regulator WR52_03125 ENOG4105C5Y PTS System WR52_03130 ENOG4105CG3 alpha amylase, catalytic region WR52_03145 ENOG4105E1K spore germination protein WR52_03150 ENOG4105CRN Aminoglycoside phosphotransferase WR52_03155 ENOG4105BZG amino acid carrier protein WR52_03165 ENOG4105CDA abc transporter atp-binding protein WR52_03170 ENOG4105CT1 (ABC) transporter WR52_03175 ENOG4105EAD ABC transporter WR52_03180 ENOG4105DRP amino acid AbC transporter WR52_03185 ENOG4108IQI permease WR52_03200 ENOG4105D29 Helix-turn-helix type 11 domain protein WR52_03205 ENOG4105NAE bifunctional deaminase-reductase domain protein WR52_03210 ENOG4105BZU Histidine kinase WR52_03235 ENOG4105CHH sulfate transporter WR52_03240 ENOG41068KF Universal stress protein WR52_03250 ENOG4105CXY transporter WR52_03255 ENOG41067TZ transcriptional regulator, MarR family WR52_03260 ENOG4105C0R drug resistance transporter emrb qaca subfamily WR52_03265 ENOG4105ETE Transcriptional regulator (LacI family WR52_03270 ENOG4108RVA ribokinase WR52_03280 ENOG4105C2J ABC transporter WR52_03285 ENOG4105CNN ABC, transporter WR52_03290 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator WR52_03295 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) WR52_03325 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) WR52_03355 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) WR52_03360 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer WR52_03365 ENOG41069ER domain protein WR52_03370 ENOG4105VZ8 Transcriptional regulator WR52_03375 ENOG4107D63 WR52_03390 ENOG4105DUX Transporter WR52_03410 ENOG4105C85 amino acid WR52_03415 ENOG4105C7N Xanthine uracil vitamin C permease WR52_03425 ENOG4105D7V transposase WR52_03440 ENOG4105MA6 gCN5-related N-acetyltransferase WR52_03465 ENOG4105BZ9 Cytochrome C oxidase, subunit I WR52_03470 ENOG4105E2S oxidase) subunit II WR52_03490 ENOG4106CAD Protein of unknown function (DUF3311) WR52_03495 ENOG4105E1V na solute symporter WR52_03510 ENOG4108NHD germination protein WR52_03520 ENOG4105CE1 Ferrous iron transport protein b WR52_03525 ENOG4105CE1 Ferrous iron transport protein b WR52_03530 ENOG4105CE1 Ferrous iron transport protein b WR52_03535 ENOG4105CVA phosphate WR52_03540 ENOG4105C8U phosphate abc transporter WR52_03545 ENOG4105E2Z phosphate ABC transporter (Permease WR52_03675 ENOG41080XQ Signal transduction protein with cbs domains WR52_03710 ENOG4105ETU transcriptional activator (TenA WR52_03720 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component WR52_03730 ENOG4108VEU Thiamine monophosphate synthase WR52_03735 ENOG41080HI glycine oxidase WR52_03750 ENOG4105D06 uba thif-type nad fad binding protein WR52_03755 ENOG4105DWF phosphomethylpyrimidine kinase WR52_03805 ENOG4108INS Transcriptional regulator WR52_03820 ENOG4105C7N Xanthine uracil vitamin C permease WR52_03830 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein WR52_03850 ENOG4105C5Y PTS System WR52_03865 ENOG4105K63 Thioredoxin WR52_03885 ENOG4108B31 Spore germination protein WR52_03905 ENOG4107Y03 Nitroreductase WR52_03910 ENOG4105ED1 spovr family WR52_03920 ENOG4105J4Q Transcriptional regulator WR52_03935 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase WR52_03940 ENOG4105XTG Pfam:DUF156 WR52_03945 ENOG4105VFE sira family WR52_03950 ENOG4107TPS domain protein WR52_03955 ENOG4105VFE sira family WR52_03965 ENOG41085GJ domain protein WR52_03970 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase WR52_03975 ENOG41087NI Sulfite exporter TauE/SafE WR52_03985 ENOG4108KGH TRANSCRIPTIONal WR52_04010 ENOG4105EMD TRANSCRIPTIONal WR52_04015 ENOG4105VCP PTS System WR52_04020 ENOG4105VZJ PTS System WR52_04040 ENOG41069ER domain protein WR52_04045 ENOG4107RBB ABC transporter, permease WR52_04050 ENOG4105C19 ABC transporter WR52_04080 ENOG4105WEF catalase WR52_04115 ENOG4107T5V SNARE associated Golgi WR52_04150 ENOG4105CUB amino acid WR52_04155 ENOG4107RWR Sodium hydrogen exchanger WR52_04165 ENOG4106KNT transcriptional regulator WR52_04170 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate WR52_04205 ENOG4108YXU transcriptional regulator AsnC family WR52_04210 ENOG4105CH7 arginosuccinase WR52_04215 ENOG4105UBK short-chain dehydrogenase reductase WR52_04225 ENOG4105KPY Small multidrug resistance protein WR52_04230 ENOG4105KPY Small multidrug resistance protein WR52_04255 ENOG4105NF4 modulator of drug activity WR52_04260 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) WR52_04265 ENOG4105E5W Transporter WR52_04275 ENOG4107RKG DJ-1/PfpI family WR52_04280 ENOG4105CH6 catalase WR52_04290 ENOG4105D5Q Arginine ornithine antiporter WR52_04295 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) WR52_04305 ENOG4105C26 Dehydrogenase WR52_04315 ENOG4105BZ1 (ABC) transporter WR52_04320 ENOG4105BZ1 (ABC) transporter WR52_04330 ENOG4105DRP amino acid AbC transporter WR52_04335 ENOG4105CDA abc transporter atp-binding protein WR52_04350 ENOG410839P WR52_04360 ENOG4108UH6 UPF0754 membrane protein WR52_04370 ENOG4105BZU Histidine kinase WR52_04375 ENOG4105WH1 Two component transcriptional regulator luxr family WR52_04385 ENOG4107FQX Alpha-acetolactate decarboxylase WR52_04405 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase WR52_04410 ENOG4105D4P Coproporphyrinogen iii oxidase WR52_04415 ENOG4105CEY Amp-dependent synthetase and ligase WR52_04430 ENOG4105CHH sulfate transporter WR52_04455 ENOG4105CGU Enoyl-CoA hydratase WR52_04475 ENOG4105DER m42 family WR52_04490 ENOG4105DQ6 Transposase WR52_04510 ENOG4105CIF Ornithine Cyclodeaminase WR52_04525 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component WR52_04535 ENOG4108JQ7 (ABC) transporter WR52_04580 ENOG4108IBT Inherit from COG: transposase WR52_04635 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) WR52_04675 ENOG4105CSH Transporter WR52_04685 ENOG4108MRH transcriptional regulatory protein WR52_04705 ENOG4107SCJ type I restriction enzyme EcoKI subunit R WR52_04745 ENOG4105CDU Replicative dna helicase WR52_04770 ENOG4105C0R drug resistance transporter emrb qaca subfamily WR52_04785 ENOG4105D9U N-acetyltransferase WR52_04810 ENOG4105F6J Alpha beta hydrolase fold WR52_04865 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase WR52_04880 ENOG4105CMT Dihydroxyacetone kinase WR52_04890 ENOG4105CMT Dihydroxyacetone kinase WR52_04925 ENOG41069ER domain protein WR52_04955 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) WR52_05040 ENOG4105WN5 stage II sporulation protein WR52_05050 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WR52_05060 ENOG4108MJI response regulator WR52_05065 ENOG4105BZU Histidine kinase WR52_05070 ENOG4105BZU Histidine kinase WR52_05095 ENOG4105K8R UPF0145 protein WR52_05110 ENOG4107QHE Choloylglycine hydrolase WR52_05130 ENOG4107VRP DNA repair exonuclease WR52_05135 ENOG4106D4I domain protein WR52_05155 ENOG410829K Lysine exporter protein (Lyse ygga) WR52_05180 ENOG4108MUZ hydrolase WR52_05200 ENOG4105F0F Oxalate decarboxylase WR52_05210 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator WR52_05225 ENOG4105C6V Glycerol-3-phosphate dehydrogenase WR52_05300 ENOG4105EMN RNA polymerase sigma factor WR52_05310 ENOG4105CNI cell division protein FtsW WR52_05320 ENOG4105EEM helicase WR52_05330 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) WR52_05360 ENOG4105K59 histidine triad (HIT) protein WR52_05390 ENOG410905X membrane-flanked domain protein WR52_05395 ENOG4105CKV Membrane WR52_05435 ENOG410905X membrane-flanked domain protein WR52_05440 ENOG4105CKV Membrane WR52_05445 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation WR52_05450 ENOG4105BZ4 penicillin-binding protein WR52_05460 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) WR52_05465 ENOG4105C1Q protoporphyrinogen oxidase WR52_05495 ENOG4105ECB domain protein WR52_05520 ENOG4105D29 Helix-turn-helix type 11 domain protein WR52_05530 ENOG4106AXD WR52_05535 ENOG4108RQ5 Beta-lactamase domain-containing protein WR52_05540 ENOG4105DF9 Lipoate-protein, ligase WR52_05550 ENOG4105CEY Amp-dependent synthetase and ligase WR52_05590 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) WR52_05600 ENOG4107RN3 metallophosphoesterase WR52_05605 ENOG4107TVP HD domain protein WR52_05610 ENOG4108AEY RNA polymerase sigma factor WR52_05615 ENOG41086D8 Transcriptional regulator WR52_05630 ENOG4105DPZ Two component transcriptional regulator (Winged helix family WR52_05650 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 WR52_05655 ENOG4105C8Q Methyl-accepting chemotaxis WR52_05660 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) WR52_05670 ENOG4107QP3 malate synthase g WR52_05695 ENOG4105VEQ Cold shock protein WR52_05730 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation WR52_05775 ENOG4105ERH Fumarylacetoacetate hydrolase WR52_05785 ENOG4105C8Y Acetylornithine aminotransferase WR52_05790 ENOG4106BKT UPF0344 protein WR52_05800 ENOG4105CAQ asparagine synthetase WR52_05805 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) WR52_05810 ENOG4105CH6 catalase WR52_05815 ENOG4105BZU Histidine kinase WR52_05830 ENOG4108VPT UPF0234 protein WR52_05835 ENOG4105QNR S1 RNA binding domain protein WR52_05840 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) WR52_05850 ENOG4107AYK membrAne WR52_05855 ENOG41073B9 WR52_05865 ENOG4108KP7 hydrolase WR52_05880 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit WR52_05905 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) WR52_05910 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) WR52_05925 ENOG4105C31 Tryptophanyl-tRNA synthetase WR52_05940 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component WR52_05945 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component WR52_05955 ENOG4108JQ7 (ABC) transporter WR52_05960 ENOG4105UQX Mate efflux family protein WR52_05985 ENOG4108ZCF integral membrane protein WR52_05995 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) WR52_06005 ENOG4105DQ6 Transposase WR52_06015 ENOG4105DPN Oligoendopeptidase f WR52_06030 ENOG4108Z18 K06886 hemoglobin WR52_06035 ENOG4105MIX Adenylate cyclase WR52_06040 ENOG4106EFP UPF0738 protein WR52_06050 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) WR52_06055 ENOG4105EMS pseudouridine synthase WR52_06075 ENOG4105K64 Glycosyl transferase, family 2 WR52_06095 ENOG4107TVC Glycosyl transferase, family 2 WR52_06115 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) WR52_06120 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase WR52_06130 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase WR52_06180 ENOG4108ZMI UPF0477 protein WR52_06205 ENOG4105CK7 Sodium proline symporter WR52_06215 ENOG4105CRQ synthase (Component I) WR52_06220 ENOG4105DDQ anthranilate synthase WR52_06230 ENOG4105DK0 Indole-3-glycerol phosphate synthase WR52_06240 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) WR52_06245 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) WR52_06310 ENOG4105C7S Dehydrogenase WR52_06315 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 WR52_06320 ENOG4105VZ8 Transcriptional regulator WR52_06380 ENOG4105DZ1 carboxypeptidase WR52_06385 ENOG4105VFR signal peptidase WR52_06420 ENOG4105C26 Dehydrogenase WR52_06425 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) WR52_06430 ENOG4105F38 ABC transporter, permease WR52_06435 ENOG4105D38 putrescine abc transporter WR52_06440 ENOG4107RUE extracellular solute-binding protein family 1 WR52_06450 ENOG4105EYF MMPL domain protein WR52_06460 ENOG4108YBP pseudouridine synthase WR52_06470 ENOG4105K4I Scp-like extracellular WR52_06475 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) WR52_06480 ENOG4105CQB FAD linked oxidase domain protein WR52_06495 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR52_06500 ENOG4105BZU Histidine kinase WR52_06505 ENOG4105JXH GntR family transcriptional regulator WR52_06525 ENOG4106A3R peptidase WR52_06535 ENOG4108QTI )-transporter WR52_06540 ENOG4107TS3 membrane protein, TerC WR52_06545 ENOG4105CZN Potassium uptake protein WR52_06550 ENOG410681C small acid-soluble spore protein WR52_06555 ENOG4108Z7G MaoC domain protein dehydratase WR52_06575 ENOG4105CHR reductase WR52_06605 ENOG4105C4Y ABC transporter WR52_06610 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) WR52_06615 ENOG4107RCV ABC transporter, permease WR52_06635 ENOG4105E98 transcriptional regulator DeoR family WR52_06650 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) WR52_06660 ENOG4105PXI polysaccharide deacetylase WR52_06675 ENOG4105BZU Histidine kinase WR52_06680 ENOG41090MY MarR family Transcriptional regulator WR52_06690 ENOG4106DF1 WR52_06700 ENOG4105BZU Histidine kinase WR52_06705 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) WR52_06710 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase WR52_06715 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) WR52_06765 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) WR52_06770 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) WR52_06775 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) WR52_06780 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family WR52_06785 ENOG4105CZV ABC transporter WR52_06795 ENOG4105CJ1 ABC, transporter WR52_06835 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A WR52_06840 ENOG4105EA8 2-Nitropropane dioxygenase WR52_06845 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD WR52_06855 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein WR52_06880 ENOG4105NQC Flavodoxin WR52_06920 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) WR52_06955 ENOG4105CZN Potassium uptake protein WR52_06960 ENOG41063Y9 WR52_06965 ENOG4105KBJ sporulation protein ytfj WR52_06995 ENOG4105CM2 brancheD-chain amino acid aminotransferase WR52_07000 ENOG4105C7K acetolactate synthase WR52_07005 ENOG4108ZP8 Acetolactate synthase small subunit WR52_07010 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase WR52_07025 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) WR52_07040 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) WR52_07045 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) WR52_07050 ENOG4105ECC imidazole-glycerol-phosphate dehydratase WR52_07055 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) WR52_07060 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase WR52_07080 ENOG4107RVV histidinol phosphate phosphatase, hisj family WR52_07095 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase WR52_07100 ENOG4105E0M Sulfatase WR52_07110 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) WR52_07125 ENOG4107S4M Sulfate adenylate transferase WR52_07130 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) WR52_07135 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) WR52_07145 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) WR52_07150 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein WR52_07155 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein WR52_07165 ENOG4105C8J )-transporter WR52_07185 ENOG4105DFD Na H antiporter WR52_07205 ENOG4105ENE Histidine kinase WR52_07210 ENOG4105WH1 Two component transcriptional regulator luxr family WR52_07230 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) WR52_07255 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) WR52_07280 ENOG4105CJ3 phosphate transporter WR52_07285 ENOG4107GRR phosphate transport regulator WR52_07290 ENOG4105BZ4 penicillin-binding protein WR52_07305 ENOG4105BZU Histidine kinase WR52_07310 ENOG4105I3N Conserved Protein WR52_07325 ENOG4105BZU Histidine kinase WR52_07355 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) WR52_07360 ENOG4105DZ1 carboxypeptidase WR52_07365 ENOG4108JIC nucleoside recognition domain protein WR52_07375 ENOG4105FE9 pseudouridine synthase WR52_07380 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen WR52_07385 ENOG4107TWT Cytochrome c biogenesis protein WR52_07390 ENOG4105CRE cytochrome C WR52_07395 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR52_07400 ENOG4105BZU Histidine kinase WR52_07405 ENOG4108WBT adenosyltransferase WR52_07420 ENOG4108SAX Membrane WR52_07435 ENOG4105C9U ATP-dependent DNA helicase RecQ WR52_07440 ENOG4105I7S Abortive infection protein WR52_07450 ENOG4107RGJ metallophosphoesterase WR52_07455 ENOG4108XDN Transcriptional regulator WR52_07460 ENOG4108S6Z Negative regulator of genetic competence WR52_07485 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase WR52_07490 ENOG4107RB3 L-asparaginase WR52_07525 ENOG4105S2F WR52_07530 ENOG41065D1 WR52_07560 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) WR52_07575 ENOG4105XXQ heptaprenyl diphosphate synthase component I WR52_07585 ENOG4105EAH synthase WR52_07590 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) WR52_07595 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase WR52_07610 ENOG41068YB TPR repeat-containing protein WR52_07625 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) WR52_07630 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) WR52_07665 ENOG4108JYZ YitT family WR52_07670 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase WR52_07685 ENOG4105FJR Lmbe family WR52_07690 ENOG4105CPK Glycosyl transferase (Group 1 WR52_07710 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) WR52_07725 ENOG4105DVT helicase WR52_07730 ENOG4105YAC WR52_07750 ENOG4105CSM endonuclease III WR52_07760 ENOG4105BZ4 penicillin-binding protein WR52_07810 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) WR52_07820 ENOG4105DVT helicase WR52_07825 ENOG4105CTD carboxy-peptidase WR52_07835 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) WR52_07840 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) WR52_07845 ENOG4105C2W permease WR52_07850 ENOG4105DHF Membrane WR52_07855 ENOG410890F Dynamin family WR52_07865 ENOG4108W0I acetyltransferase WR52_07875 ENOG4105KHC sulfurtransferase WR52_07920 ENOG4105HTX biosynthesis protein WR52_07950 ENOG4105CPK Glycosyl transferase (Group 1 WR52_07965 ENOG4108SZE gCN5-related N-acetyltransferase WR52_07985 ENOG41081VK Ribonuclease WR52_08050 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) WR52_08060 ENOG4107RWR Sodium hydrogen exchanger WR52_08065 ENOG4105CN5 Metallo-Beta-Lactamase WR52_08070 ENOG4108Z5V transcriptional regulator, merr family WR52_08080 ENOG4105H67 Protein of unknown function (DUF421) WR52_08085 ENOG41080C8 DUF218 domain WR52_08120 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) WR52_08130 ENOG4107R0U MotA TolQ exbB proton channel WR52_08135 ENOG4105ER2 Ompa motb domain protein WR52_08140 ENOG4107YTP response regulator receiver protein WR52_08145 ENOG4105CBS Chea signal transduction histidine kinase WR52_08150 ENOG4105DD5 Flagellar motor switch protein WR52_08165 ENOG4105BZU Histidine kinase WR52_08185 ENOG4105E1Q flagellar hook-associated protein WR52_08190 ENOG4105DTJ flagellar hook-associated protein WR52_08210 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) WR52_08215 ENOG4108ZC9 flagellar basal-body rod protein flgc WR52_08220 ENOG41075Z6 flagellar hook-basal body complex protein fliE WR52_08225 ENOG4107U2N Flagellar M-ring protein WR52_08230 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) WR52_08260 ENOG4105BZE flagellar hook protein, FlgE WR52_08275 ENOG4107R88 Chemotaxis protein (CheV) WR52_08285 ENOG4105I03 Flagellin WR52_08290 ENOG4105I03 Flagellin WR52_08295 ENOG4105E4C Lytic transglycosylase catalytic WR52_08305 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) WR52_08310 ENOG4105DD5 Flagellar motor switch protein WR52_08320 ENOG4105CN7 Flagellar biosynthetic protein FliP WR52_08325 ENOG4105VS8 Flagellar biosynthetic protein fliq WR52_08335 ENOG4105D00 flagellar biosynthetic protein flhB WR52_08340 ENOG4105D7B Flagellar biosynthesis protein flha WR52_08345 ENOG4105FZW flagellar biosynthesis regulator FlhF WR52_08350 ENOG4105KTQ flagellar basal-body rod protein WR52_08355 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) WR52_08390 ENOG4105KAC Antibiotic biosynthesis monooxygenase WR52_08415 ENOG4105DUM transcriptional regulator, lysR family WR52_08430 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component WR52_08435 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) WR52_08460 ENOG4105CVJ phosphoglycerate mutase WR52_08470 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) WR52_08490 ENOG4105CAQ asparagine synthetase WR52_08510 ENOG4105PGM cation diffusion facilitator family transporter WR52_08520 ENOG4105DRR Transcriptional regulator, GntR family WR52_08525 ENOG4108UZ3 Transporter WR52_08535 ENOG4105CKI cobalamin synthesis protein WR52_08540 ENOG4108PJD permease WR52_08555 ENOG4105DFD Na H antiporter WR52_08560 ENOG4105VUF Transcriptional regulator WR52_08570 ENOG4105C9Q fumarate hydratase class II WR52_08595 ENOG4107QJQ Mate efflux family protein WR52_08600 ENOG4105EC3 peptidase S51, dipeptidase E WR52_08620 ENOG4107QIV Cytochrome c biogenesis protein WR52_08635 ENOG4107JM4 Tetratricopeptide repeat WR52_08650 ENOG4105BZC d-serine deaminase WR52_08655 ENOG4106BRA Membrane WR52_08690 ENOG4105CJ1 ABC, transporter WR52_08710 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) WR52_08720 ENOG4108IJ0 Aspartate ammonia-lyase WR52_08725 ENOG4105C6K Malic enzyme WR52_08785 ENOG4105FVX WR52_08790 ENOG4105E09 nadh pyrophosphatase WR52_08805 ENOG4105CSR polyphosphate kinase 2 WR52_08810 ENOG4105U3E Transcriptional regulator WR52_08825 ENOG4105DXI Major Facilitator superfamily WR52_08835 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) WR52_08840 ENOG4105EU0 Major facilitator Superfamily WR52_08845 ENOG4105C6T cysteine synthase WR52_08865 ENOG4105C8J )-transporter WR52_08875 ENOG4105X5K response regulator receiver protein WR52_08880 ENOG4105H67 Protein of unknown function (DUF421) WR52_08900 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) WR52_08905 ENOG4105CHR reductase WR52_08910 ENOG4105CM2 brancheD-chain amino acid aminotransferase WR52_08915 ENOG4105C7K acetolactate synthase WR52_08925 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase WR52_08935 ENOG4105C7B Threonine dehydratase WR52_08960 ENOG4105C6X Major Facilitator WR52_08965 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b WR52_08975 ENOG4105DY9 regulatoR WR52_08980 ENOG4105CYC Transferase WR52_08995 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) WR52_09005 ENOG41068WN WR52_09010 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) WR52_09025 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) WR52_09035 ENOG4105C0X amino acid WR52_09080 ENOG410849A acetyltransferase, (GNAT) family WR52_09100 ENOG4107RHR regulatoR WR52_09110 ENOG4105D9N nucleoside WR52_09115 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) WR52_09150 ENOG4107RAQ aminopeptidase WR52_09160 ENOG4107R16 Multicopper oxidase WR52_09185 ENOG4105D6J arsenicaL-resistance protein WR52_09205 ENOG4108T5E Copper resistance protein WR52_09210 ENOG4105KTB nuclear export factor GLE1 WR52_09215 ENOG4107RT3 EamA-like transporter family WR52_09220 ENOG4105GZI Transcriptional regulator WR52_09225 ENOG4108Z40 Transcriptional regulator WR52_09230 ENOG4107ZXU DSBA oxidoreductase WR52_09235 ENOG4108TVJ Nitroreductase WR52_09245 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) WR52_09250 ENOG4106F5Q Membrane WR52_09255 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) WR52_09265 ENOG4105CKI cobalamin synthesis protein WR52_09275 ENOG4105C0Z ABC transporter WR52_09280 ENOG4108IV0 ABC, transporter WR52_09285 ENOG4105C32 Amino acid ABC transporter (Permease) WR52_09295 ENOG4105SKE transcriptional Regulator LysR family WR52_09315 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes WR52_09325 ENOG4105C4M (Ubiquinol oxidase) subunit I WR52_09330 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii WR52_09335 ENOG4108JJ9 ABC, transporter WR52_09340 ENOG4108JJ8 (ABC) transporter WR52_09350 ENOG4105K64 Glycosyl transferase, family 2 WR52_09360 ENOG4108UT6 Transferase hexapeptide repeat containing protein WR52_09415 ENOG4105BZ1 (ABC) transporter WR52_09420 ENOG4105EFI regulatoR WR52_09425 ENOG4105BZU Histidine kinase WR52_09440 ENOG41075D4 Aminoglycoside 6-adenylyltransferase WR52_09445 ENOG4108ZJ4 polysaccharide deacetylase WR52_09465 ENOG4105D6E homoserine dehydrogenase WR52_09475 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) WR52_09490 ENOG4108KGH TRANSCRIPTIONal WR52_09500 ENOG4105DPZ Two component transcriptional regulator (Winged helix family WR52_09505 ENOG4105BZU Histidine kinase WR52_09510 ENOG4107VMI polysaccharide deacetylase WR52_09520 ENOG4105KT7 mgtC SapB transporter WR52_09525 ENOG4105VRR gCN5-related N-acetyltransferase WR52_09535 ENOG4105DUU IucA IucC family protein WR52_09540 ENOG4105CEY Amp-dependent synthetase and ligase WR52_09555 ENOG4108WBH protein TIM barrel WR52_09560 ENOG4105YWU small acid-soluble spore protein WR52_09570 ENOG4108ZUB Lysine exporter protein (Lyse ygga) WR52_09575 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WR52_09620 ENOG4105DQ6 Transposase WR52_09635 ENOG4105KRN Transcriptional regulator, abrb family WR52_09645 ENOG4105YVS arsR family transcriptional regulator WR52_09650 ENOG4105CPC Aldo Keto reductase WR52_09655 ENOG4107XZQ multidrug resistance protein WR52_09665 ENOG4105KAF membrAne WR52_09690 ENOG4105C8Q Methyl-accepting chemotaxis WR52_09710 ENOG4108K88 Membrane WR52_09715 ENOG4108WPJ Ferritin-like domain WR52_09730 ENOG4105DEN Luciferase family WR52_09745 ENOG4105VMI -acetyltransferase WR52_09750 ENOG4107QM2 Aldo Keto reductase WR52_09755 ENOG4105CKI cobalamin synthesis protein WR52_09765 ENOG4105DSE periplasmic solute binding protein WR52_09775 ENOG4105K4T epimerase WR52_09785 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) WR52_09830 ENOG4107T5V SNARE associated Golgi WR52_09845 ENOG4108PJD permease WR52_09855 ENOG4108S4H thioesterase Superfamily protein WR52_09860 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) WR52_09880 ENOG4105SXS Protein of unknown function (DUF456) WR52_09885 ENOG4105C37 (CBS) domain WR52_09905 ENOG4108Z7R Chaperone CsaA WR52_09925 ENOG4108ZRV stage ii sporulation protein p WR52_09935 ENOG4108VXD carboxy-peptidase WR52_09960 ENOG4108ZRV stage ii sporulation protein p WR52_09970 ENOG4108X4Q Hydrolase WR52_09985 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) WR52_10000 ENOG41087PP glycosyltransferase MGT family WR52_10005 ENOG4108JYZ YitT family WR52_10010 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WR52_10040 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) WR52_10065 ENOG4106PAW secretion accessory protein EsaA YueB WR52_10075 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) WR52_10080 ENOG4108MGT Required for secretion of EsxA and EsxB WR52_10145 ENOG4105KBJ sporulation protein ytfj WR52_10170 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) WR52_10190 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) WR52_10195 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily WR52_10205 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein WR52_10210 ENOG4105EMN RNA polymerase sigma factor WR52_10225 ENOG4105CNW domain protein WR52_10235 ENOG4108V06 Glutathione peroxidase WR52_10250 ENOG4105C7R Atpase associated with various cellular activities aaa_3 WR52_10260 ENOG4108IUE nitrate reductase beta subunit WR52_10265 ENOG4105R3A Nitrate reductase WR52_10275 ENOG4107V6Q Cyclic nucleotide-binding domain WR52_10280 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) WR52_10285 ENOG4105D06 uba thif-type nad fad binding protein WR52_10290 ENOG4105CVM Molybdenum cofactor synthesis domain protein WR52_10295 ENOG4108ZAF Molybdopterin WR52_10325 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein WR52_10330 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein WR52_10335 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) WR52_10340 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit WR52_10345 ENOG4108IFG nitrite reductase, (NAD(P)H) WR52_10350 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) WR52_10370 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase WR52_10385 ENOG4105MCT stage V sporulation protein S WR52_10420 ENOG4107T65 Integrase WR52_10425 ENOG410635T phage-like element pbsx protein WR52_10430 ENOG4108IMY Transcriptional regulator WR52_10485 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein WR52_10545 ENOG4108C33 Resolvase WR52_10560 ENOG4105IG6 Phage terminase, large subunit WR52_10685 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis WR52_10745 ENOG4105C5H ABC transporter WR52_10760 ENOG4108UUM single-stranded DNA-binding protein WR52_10780 ENOG4107YX5 Pfam:DUF548 WR52_10785 ENOG4105C75 arginyL-tRNA synthetase WR52_10815 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) WR52_10830 ENOG4105C5S asparaginyl-tRNA synthetase WR52_10835 ENOG4105BZW Glycerate kinase WR52_10845 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR52_10850 ENOG41062D9 Histidine kinase WR52_10865 ENOG4105C8J )-transporter WR52_10885 ENOG4107XGZ Hydrolase WR52_10890 ENOG4105CY2 Citrate transporter WR52_10910 ENOG4105KD7 acetyltransferase WR52_10920 ENOG4105VMP Transcriptional regulator WR52_10925 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase WR52_10950 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 WR52_10965 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) WR52_10970 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) WR52_10980 ENOG4107RVG penicillin-binding protein WR52_10985 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) WR52_10990 ENOG4105E9Q Acyl-transferase WR52_10995 ENOG4108UT2 hemolysin iii WR52_11005 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) WR52_11015 ENOG4108RCR degv family WR52_11025 ENOG4108KF3 Electron transport protein SCO1 SenC WR52_11030 ENOG4107Y70 Heat shock protein WR52_11035 ENOG4105CAQ asparagine synthetase WR52_11050 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase WR52_11055 ENOG4108MES Periplasmic binding protein WR52_11060 ENOG4105F0I Aminotransferase WR52_11145 ENOG4105DQ6 Transposase WR52_11150 ENOG4105D8X mechanosensitive ion channel WR52_11155 ENOG4105BZU Histidine kinase WR52_11160 ENOG4105WH1 Two component transcriptional regulator luxr family WR52_11165 ENOG4106KNT transcriptional regulator WR52_11170 ENOG4107ZY0 Phenazine biosynthesis-like protein WR52_11190 ENOG4105CMG Carbohydrate kinase WR52_11195 ENOG4105C6Z Gluconate WR52_11205 ENOG4108YV3 Protein of unknown function (DUF2711) WR52_11235 ENOG4108IJ8 ABC transporter WR52_11240 ENOG4105E90 ABC transporter WR52_11275 ENOG4105C37 (CBS) domain WR52_11300 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) WR52_11315 ENOG4107S4Y M20 DapE family protein YgeY WR52_11320 ENOG4108TSC N-acetyltransferase WR52_11325 ENOG4108JUB Transcriptional regulator WR52_11330 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein WR52_11375 ENOG410841Q phosphoesterase PA-phosphatase related protein WR52_11385 ENOG4105SZ6 Thioredoxin WR52_11450 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) WR52_11505 ENOG4105BZ4 penicillin-binding protein WR52_11515 ENOG4105CZM Major Facilitator WR52_11520 ENOG4105W8X HesB YadR YfhF-family protein WR52_11530 ENOG4105DXD 2-methylcitrate dehydratase WR52_11535 ENOG4105CR4 methylisocitrate lyase WR52_11540 ENOG4105C1G acyl-Coa dehydrogenase WR52_11545 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase WR52_11555 ENOG4105N14 lysine exporter protein LysE YggA WR52_11560 ENOG4105E39 Enoyl-CoA hydratase WR52_11575 ENOG4107RFY SbcCD D subunit WR52_11580 ENOG4105EYH Exonuclease WR52_11605 ENOG4105FCD Major Facilitator WR52_11610 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase WR52_11615 ENOG4105E4F Isochorismate synthase WR52_11620 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase WR52_11625 ENOG4105WQI isochorismatase WR52_11630 ENOG4105CEY Amp-dependent synthetase and ligase WR52_11635 ENOG4105WQT MbtH domain protein WR52_11640 ENOG4105C0R drug resistance transporter emrb qaca subfamily WR52_11655 ENOG4105K70 DNA-binding protein WR52_11675 ENOG4105BZG amino acid carrier protein WR52_11695 ENOG4105FE9 pseudouridine synthase WR52_11700 ENOG4105C22 threonyL-tRNA synthetase WR52_11705 ENOG4105C19 ABC transporter WR52_11745 ENOG41081I9 integral membrane protein WR52_11755 ENOG4108Y4K DNA-binding transcriptional activator WR52_11770 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) WR52_11780 ENOG4105EYF MMPL domain protein WR52_11805 ENOG4105WCN acetyltransferase WR52_11830 ENOG4105C1Q protoporphyrinogen oxidase WR52_11840 ENOG41068WN WR52_11870 ENOG4107V2S Transcriptional regulator WR52_11875 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) WR52_11895 ENOG4105DND Transcriptional regulator WR52_11900 ENOG4108RPX mosc domain containing protein WR52_11915 ENOG4105BZ1 (ABC) transporter WR52_11920 ENOG4105BZ1 (ABC) transporter WR52_11950 ENOG4108JCI Transcriptional regulator WR52_11990 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) WR52_11995 ENOG4108KPJ rna polymerase sigma factor WR52_12020 ENOG4105F32 YngK protein WR52_12040 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) WR52_12045 ENOG4105RD7 BadF BadG BcrA BcrD WR52_12050 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) WR52_12055 ENOG4107STF Involved in phosphonate degradation (By similarity) WR52_12065 ENOG4108INS Transcriptional regulator WR52_12080 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) WR52_12090 ENOG4105C1J atp-dependent rna helicase WR52_12105 ENOG4108RZE Tetr family transcriptional regulator WR52_12125 ENOG41088CC tellurite resistance protein tehB WR52_12145 ENOG4105K56 Transcriptional regulator WR52_12150 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) WR52_12175 ENOG4105CIN aminoacyl-histidine dipeptidase WR52_12185 ENOG4105DQ6 Transposase WR52_12210 ENOG4105KRN Transcriptional regulator, abrb family WR52_12220 ENOG4105EJ9 Membrane WR52_12225 ENOG4105EQK -acetyltransferase WR52_12295 ENOG4107RVG penicillin-binding protein WR52_12310 ENOG4107RF6 penicillin-binding protein WR52_12315 ENOG4107RF6 penicillin-binding protein WR52_12325 ENOG4105DIN metallophosphoesterase WR52_12335 ENOG4105CJ1 ABC, transporter WR52_12345 ENOG4107Z3H Transcriptional regulator, TetR family WR52_12360 ENOG4105C1G acyl-Coa dehydrogenase WR52_12365 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase WR52_12370 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit WR52_12375 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase WR52_12380 ENOG4105E39 Enoyl-CoA hydratase WR52_12385 ENOG4107QX3 carboxylase WR52_12390 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) WR52_12410 ENOG4105DBI uridine monophosphokinase WR52_12425 ENOG4105DZ1 carboxypeptidase WR52_12440 ENOG4105T9C HD domain WR52_12455 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) WR52_12480 ENOG41075H3 AraC family transcriptional regulator WR52_12510 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) WR52_12530 ENOG41089UC methyltransferase, type 11 WR52_12535 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) WR52_12545 ENOG4105MDS 4-oxalocrotonate tautomerase WR52_12550 ENOG4107V2S Transcriptional regulator WR52_12605 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein WR52_12615 ENOG4105DK7 lysyl-tRNA synthetase WR52_12675 ENOG4105D6E homoserine dehydrogenase WR52_12685 ENOG4105CPF Cell wall formation (By similarity) WR52_12690 ENOG4105ETU transcriptional activator (TenA WR52_12715 ENOG4105VTR Integrase WR52_12760 ENOG4105KRN Transcriptional regulator, abrb family WR52_12830 ENOG4105CUB amino acid WR52_12835 ENOG4105DQ6 Transposase WR52_12945 ENOG4105XSJ toxin secretion phage lysis holin WR52_13025 ENOG410667J hydrolase WR52_13030 ENOG4105BZU Histidine kinase WR52_13035 ENOG4107RF6 penicillin-binding protein WR52_13060 ENOG4108JJB ABC transporter WR52_13070 ENOG4108HGU Histidine kinase WR52_13080 ENOG4105DQ6 Transposase WR52_13130 ENOG4105CB2 alcohol dehydrogenase WR52_13135 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase WR52_13140 ENOG4105CJN penicillin-binding protein WR52_13180 ENOG4108V4B ThiJ pfpI WR52_13195 ENOG4107VXM glycerophosphoryl diester phosphodiesterase WR52_13220 ENOG4107Y9U Membrane WR52_13235 ENOG4105EGD dinuclear metal center protein, YbgI family WR52_13260 ENOG4105FCD Major Facilitator WR52_13275 ENOG4105E09 nadh pyrophosphatase WR52_13280 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) WR52_13310 ENOG4105KME endoribonuclease L-psp WR52_13315 ENOG4108XI2 Domain of unknown function (DUF1963) WR52_13335 ENOG4108NRW Phospholipase, patatin family WR52_13340 ENOG4105KWG Pfam:DUF1696 WR52_13350 ENOG4108YYS metal-dependent hydrolase (By similarity) WR52_13365 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) WR52_13375 ENOG4105PKS Excinuclease abc c subunit domain protein WR52_13415 ENOG4107VFR oxidoreductase WR52_13450 ENOG4105U0R haloacid dehalogenase-like hydrolase WR52_13475 ENOG4105DY8 decarboxylase WR52_13490 ENOG4108IUM Glycogen debranching enzyme WR52_13515 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) WR52_13520 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) WR52_13525 ENOG4105FDR Membrane WR52_13540 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) WR52_13585 ENOG4105MSI germination protein ypeb WR52_13615 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) WR52_13620 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) WR52_13625 ENOG4107Z3H Transcriptional regulator, TetR family WR52_13655 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family WR52_13675 ENOG4105E98 transcriptional regulator DeoR family WR52_13690 ENOG41062ES Transcriptional regulator WR52_13710 ENOG4107QKR Dehydrogenase WR52_13720 ENOG4107RUY (E1 component), alpha subunit WR52_13730 ENOG4105E1F short-chain dehydrogenase reductase WR52_13760 ENOG4107SQ8 Glycine betaine WR52_13765 ENOG4108IJ7 Glycine betaine WR52_13790 ENOG4105E66 phosphoriboisomerase A WR52_13795 ENOG41082BV acetyltransferase WR52_13800 ENOG4108M1A Chitin-binding protein WR52_13845 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) WR52_13850 ENOG4105MSB protein, conserved in bacteria WR52_13875 ENOG4108Z7F N-acetyltransferase WR52_13900 ENOG4105EEM helicase WR52_13915 ENOG4105C9U ATP-dependent DNA helicase RecQ WR52_13970 ENOG4108M1A Chitin-binding protein WR52_13990 ENOG4105BZG amino acid carrier protein WR52_13995 ENOG4105C26 Dehydrogenase WR52_14000 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) WR52_14005 ENOG4105CTU Proline racemase WR52_14010 ENOG4105CTU Proline racemase WR52_14015 ENOG41080HI glycine oxidase WR52_14025 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein WR52_14060 ENOG4105DCI Phosphohydrolase WR52_14065 ENOG4107T5V SNARE associated Golgi WR52_14075 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD WR52_14095 ENOG4105DTQ mandelate racemase muconate lactonizing WR52_14110 ENOG4107SET aldo keto reductase WR52_14145 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) WR52_14150 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) WR52_14155 ENOG4105BZU Histidine kinase WR52_14160 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR52_14180 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 WR52_14195 ENOG4105DPN Oligoendopeptidase f WR52_14200 ENOG4105EPR degv family WR52_14245 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) WR52_14250 ENOG4106K7D Major facilitator family transporter WR52_14270 ENOG4107BMA Transglycosylase associated protein WR52_14285 ENOG41089UC methyltransferase, type 11 WR52_14305 ENOG4105DQ6 Transposase WR52_14330 ENOG4105CHM Aminotransferase WR52_14345 ENOG4108ZMI UPF0477 protein WR52_14360 ENOG4105DVE abc transporter atp-binding protein WR52_14365 ENOG4105FDP GntR family transcriptional regulator WR52_14415 ENOG4105C02 permease WR52_14430 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) WR52_14435 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component WR52_14445 ENOG4105D7T ABC transporter WR52_14480 ENOG4108AQF aminoglycoside N(3)-acetyltransferase WR52_14510 ENOG4107VC0 DNA alkylation repair enzyme WR52_14515 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase WR52_14530 ENOG4108ZCF integral membrane protein WR52_14535 ENOG4105E0M Sulfatase WR52_14540 ENOG4105C5H ABC transporter WR52_14545 ENOG4105EYF MMPL domain protein WR52_14550 ENOG41082JN Transcriptional regulator WR52_14575 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase WR52_14580 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase WR52_14625 ENOG41069ER domain protein WR52_14635 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase WR52_14665 ENOG4105D4B ABC, transporter WR52_14675 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane WR52_14685 ENOG4105DKT Transcriptional regulator WR52_14690 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) WR52_14700 ENOG41061GT Aldolase WR52_14705 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) WR52_14740 ENOG4105II7 pyrroline-5-carboxylate reductase WR52_14750 ENOG4107258 Transcriptional regulator WR52_14765 ENOG4105ECK Fatty Acid Desaturase WR52_14775 ENOG4107RBI VanW family WR52_14780 ENOG4105G6Z alkaline phosphatase WR52_14790 ENOG4105VMP Transcriptional regulator WR52_14810 ENOG41068WN WR52_14840 ENOG4105C7R Atpase associated with various cellular activities aaa_3 WR52_14895 ENOG4105C8Y Acetylornithine aminotransferase WR52_14920 ENOG4105DQ6 Transposase WR52_14950 ENOG4105C7R Atpase associated with various cellular activities aaa_3 WR52_15035 ENOG4108IBT Inherit from COG: transposase WR52_15055 ENOG4108TVJ Nitroreductase WR52_15060 ENOG4105FS7 Transcriptional regulator WR52_15080 ENOG4105ERH Fumarylacetoacetate hydrolase WR52_15100 ENOG4105CEY Amp-dependent synthetase and ligase WR52_15105 ENOG4105CHU acetyl-coa acetyltransferase WR52_15110 ENOG4105E39 Enoyl-CoA hydratase WR52_15115 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase WR52_15125 ENOG4105G9B Transcriptional regulator WR52_15130 ENOG4105D2S major facilitator superfamily WR52_15135 ENOG4105EFZ amidohydrolase WR52_15145 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) WR52_15165 ENOG4108DMH HTH_ARAC WR52_15170 ENOG4108XET gCN5-related N-acetyltransferase WR52_15185 ENOG4108PCN EamA-like transporter family WR52_15195 ENOG4107XJU UPF0178 protein WR52_15230 ENOG410635A Membrane WR52_15240 ENOG4108IQI permease WR52_15250 ENOG4105F1N DNA alkylation repair WR52_15280 ENOG4107RF6 penicillin-binding protein WR52_15285 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) WR52_15305 ENOG4105E7W lamb ycsf family protein WR52_15315 ENOG4105P4J Allophanate hydrolase, subunit 1 WR52_15320 ENOG4107258 Transcriptional regulator WR52_15330 ENOG4106N3A copper homeostasis protein cutc WR52_15335 ENOG4108ZHR arsR family transcriptional regulator WR52_15345 ENOG4105FDT acyl-CoA dehydrogenase WR52_15360 ENOG4105DWD nucleoside recognition domain protein WR52_15400 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) WR52_15405 ENOG4107S9D Alpha beta hydrolase WR52_15420 ENOG4108S9F abc transporter, atp-binding protein WR52_15425 ENOG4108RZA ABC transporter WR52_15430 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component WR52_15435 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component WR52_15440 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein WR52_15460 ENOG4105F2Z 3-oxoadipate enol-lactonase WR52_15530 ENOG4105E2A Dehydrogenase WR52_15535 ENOG4108IJ0 Aspartate ammonia-lyase WR52_15540 ENOG4105HDK L-asparaginase WR52_15545 ENOG4108IMY Transcriptional regulator WR52_15555 ENOG4108B31 Spore germination protein WR52_15565 ENOG4105BZU Histidine kinase WR52_15590 ENOG41075H3 AraC family transcriptional regulator WR52_15595 ENOG4105YWU small acid-soluble spore protein WR52_15600 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) WR52_15605 ENOG4105CUB amino acid WR52_15615 ENOG4105II7 pyrroline-5-carboxylate reductase WR52_15625 ENOG4105C6K Malic enzyme WR52_15635 ENOG4108NHD germination protein WR52_15640 ENOG4108Q8B Spore germination protein WR52_15700 ENOG4105CGH 5'-nucleotidase WR52_15710 ENOG4105CHJ isochorismatase hydrolase WR52_15735 ENOG41090MY MarR family Transcriptional regulator WR52_15760 ENOG4105F6J Alpha beta hydrolase fold WR52_15775 ENOG4108606 TspO/MBR family WR52_15780 ENOG4105CVP deoxyribo-dipyrimidine photolyase WR52_15795 ENOG4108TWJ NADH dehydrogenase subunit 5 WR52_15800 ENOG4105GPN Uncharacterized conserved protein (DUF2294) WR52_15805 ENOG4107VMI polysaccharide deacetylase WR52_15810 ENOG4108U7W acetyltransferase WR52_15815 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase WR52_15825 ENOG4105D6J arsenicaL-resistance protein WR52_15830 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase WR52_15835 ENOG41085FC arsR family transcriptional regulator WR52_15865 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR52_15905 ENOG4107P5I polyketide synthase WR52_15910 ENOG4108IG5 Transcriptional regulator WR52_15915 ENOG4105CHR reductase WR52_15920 ENOG4108YXU transcriptional regulator AsnC family WR52_15980 ENOG4105C44 Serine transporter WR52_15995 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase WR52_16000 ENOG4105DUM transcriptional regulator, lysR family WR52_16005 ENOG4105DWP Membrane WR52_16015 ENOG4105N0V mono-oxygenase ydhR WR52_16040 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR52_16045 ENOG41062D9 Histidine kinase WR52_16090 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) WR52_16095 ENOG4105C0R drug resistance transporter emrb qaca subfamily WR52_16105 ENOG4105K6H D-cysteine desulfhydrase WR52_16120 ENOG4105JQZ Methyltransferase WR52_16140 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) WR52_16160 ENOG4105BZU Histidine kinase WR52_16170 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) WR52_16175 ENOG4105BZU Histidine kinase WR52_16180 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR52_16195 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A WR52_16210 ENOG4105TRI Hydrolase WR52_16255 ENOG4107QJQ Mate efflux family protein WR52_16270 ENOG4105EQ0 Major Facilitator superfamily WR52_16275 ENOG4108JGH Tetr family transcriptional regulator WR52_16285 ENOG4105DVH amino acid WR52_16300 ENOG4108JQ1 Dehydrogenase WR52_16305 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) WR52_16320 ENOG41082W1 Cupin 2, conserved barrel domain protein WR52_16325 ENOG410874W AraC family transcriptional regulator WR52_16340 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase WR52_16465 ENOG4106YAD MORN repeat variant WR52_16510 ENOG4108VXD carboxy-peptidase WR52_16515 ENOG4105PNM synthesis protein WR52_16525 ENOG4108ISG Major Facilitator WR52_16540 ENOG4107MII Sugar-specific transcriptional regulator TrmB WR52_16545 ENOG4105CZM Major Facilitator WR52_16560 ENOG4105DA5 (ABC) transporter WR52_16565 ENOG41069JR WR52_16575 ENOG4105RXJ WR52_16580 ENOG4105KPY Small multidrug resistance protein WR52_16585 ENOG4105KBX Transcriptional regulator, TetR family WR52_16590 ENOG4107AUC WR52_16600 ENOG4105DQ6 Transposase WR52_16615 ENOG4105CRW Short chain fatty acid transporter WR52_16625 ENOG4105DYS nad(p)h dehydrogenase (quinone) WR52_16685 ENOG4108K8S endonuclease I WR52_16705 ENOG4108Z66 YbaK ebsC protein WR52_16710 ENOG4105CUT histidyl-tRNA synthetase WR52_16725 ENOG4105KVH Transcriptional regulator WR52_16730 ENOG4108RCM Nitroreductase WR52_16760 ENOG4108PSK reductase WR52_16825 ENOG4105C31 Tryptophanyl-tRNA synthetase WR52_16830 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) WR52_16895 ENOG4105C37 (CBS) domain WR52_16910 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase WR52_16915 ENOG4105FAW cDP-glucose 4,6-dehydratase WR52_16945 ENOG4105DDN Pentapeptide repeat-containing protein WR52_16950 ENOG4105XDF Protein of unknown function (DUF1272) WR52_16955 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) WR52_16960 ENOG4105CMG Carbohydrate kinase WR52_16965 ENOG4105C6Z Gluconate WR52_16970 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) WR52_16985 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase WR52_16990 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase WR52_16995 ENOG4105CIS alcohol dehydrogenase WR52_17000 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone WR52_17010 ENOG4105CIS alcohol dehydrogenase WR52_17025 ENOG4105EWI Short-chain dehydrogenase reductase Sdr WR52_17040 ENOG4105C8Q Methyl-accepting chemotaxis WR52_17045 ENOG4108UX3 '-nucleotidase WR52_17050 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) WR52_17055 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) WR52_17060 ENOG4105KVH Transcriptional regulator WR52_17080 ENOG4105DQ6 Transposase WR52_17085 ENOG4105CV8 reductase WR52_17090 ENOG4105F27 Major Facilitator WR52_17100 ENOG41090KN UPF0303 protein WR52_17110 ENOG4105FS7 Transcriptional regulator WR52_17115 ENOG4105C44 Serine transporter WR52_17145 ENOG4105KVH Transcriptional regulator WR52_17150 ENOG4108TZY GntR Family Transcriptional Regulator WR52_17155 ENOG4105D9R oxidoreductase WR52_17160 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase WR52_17165 ENOG4105KVH Transcriptional regulator WR52_17170 ENOG4105KVH Transcriptional regulator WR52_17210 ENOG4105JAB phenazine biosynthesis protein, phzf family WR52_17220 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein WR52_17225 ENOG4105KVH Transcriptional regulator WR52_17230 ENOG4107SCK Monooxygenase WR52_17250 ENOG4105DQ6 Transposase WR52_17330 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) WR52_17340 ENOG4107YXZ hydrolase, family 25 WR52_17375 ENOG4105H3G oxidoreductase WR52_17445 ENOG4108TN2 lmbE family WR52_17455 ENOG4107R3E Citrate transporter WR52_17465 ENOG4105WCN acetyltransferase WR52_17470 ENOG4108MES Periplasmic binding protein WR52_17475 ENOG4105EHG Permease protein WR52_17480 ENOG4105DQ5 transport system permease protein WR52_17485 ENOG4105NX3 Membrane WR52_17510 ENOG4107CUJ Protein of unknown function (DUF2690) WR52_17520 ENOG4107V2S Transcriptional regulator WR52_17540 ENOG4105C98 muts2 protein WR52_17550 ENOG4105E5K Alpha-amylase WR52_17555 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase WR52_17560 ENOG4105DPN Oligoendopeptidase f WR52_17565 ENOG4108A04 Beta-lactamase WR52_17590 ENOG4107VXM glycerophosphoryl diester phosphodiesterase WR52_17605 ENOG41082BM Transcriptional regulator, arsr family WR52_17610 ENOG4105CIS alcohol dehydrogenase WR52_17620 ENOG4107JM4 Tetratricopeptide repeat WR52_17645 ENOG4105CQB FAD linked oxidase domain protein WR52_17680 ENOG4105BZU Histidine kinase WR52_17690 ENOG4105KT7 mgtC SapB transporter WR52_17700 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase WR52_17705 ENOG41073R8 VanW family WR52_17715 ENOG4108R1P WR52_17735 ENOG4105VEQ Cold shock protein WR52_17755 ENOG4105M6F mutator MutT protein WR52_17775 ENOG410904N short-chain dehydrogenase reductase WR52_17785 ENOG4106IQC argininosuccinate lyase WR52_17800 ENOG4108IA2 Sodium pantothenate symporter WR52_17810 ENOG4105C26 Dehydrogenase WR52_17815 ENOG4105CHR reductase WR52_17825 ENOG4105EWU Squalene--hopene cyclase WR52_17835 ENOG4105FR1 rard protein WR52_17840 ENOG410696E Membrane WR52_17855 ENOG4105D1F ATP-binding protein WR52_17865 ENOG4108ZAF Molybdopterin WR52_17870 ENOG4105CVM Molybdenum cofactor synthesis domain protein WR52_17875 ENOG4105D06 uba thif-type nad fad binding protein WR52_17880 ENOG4105TMB Formate nitrite transporter WR52_17890 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) WR52_17895 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) WR52_17905 ENOG4108JB9 formate dehydrogenase WR52_17915 ENOG4105E1K spore germination protein WR52_17980 ENOG4107QJT sodium dicarboxylate symporter WR52_17985 ENOG4108KGH TRANSCRIPTIONal WR52_17995 ENOG4105EMN RNA polymerase sigma factor WR52_18005 ENOG4105CIG ABC transporter WR52_18025 ENOG4105D9R oxidoreductase WR52_18035 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) WR52_18045 ENOG4105K4P CoA-binding domain protein WR52_18050 ENOG4105C0H protease WR52_18055 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR52_18065 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase WR52_18070 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) WR52_18075 ENOG4105W8X HesB YadR YfhF-family protein WR52_18105 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) WR52_18110 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen WR52_18125 ENOG4105BZ1 (ABC) transporter WR52_18130 ENOG4105BZ1 (ABC) transporter WR52_18135 ENOG4108I0Z Aconitate hydratase WR52_18165 ENOG4105E5W Transporter WR52_18175 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) WR52_18195 ENOG4107F3J Amp-dependent synthetase and ligase WR52_18200 ENOG4107ZYJ bioY protein WR52_18205 ENOG4105CEY Amp-dependent synthetase and ligase WR52_18245 ENOG4107AYK membrAne WR52_18255 ENOG4105BZU Histidine kinase WR52_18260 ENOG4105FBA Phospholipase Carboxylesterase WR52_18265 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase WR52_18270 ENOG4105CK7 Sodium proline symporter WR52_18275 ENOG4105CBC glutamate synthase WR52_18280 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase WR52_18285 ENOG4108VJ1 Transcriptional regulator (CarD family WR52_18290 ENOG4108903 Formimidoylglutamase WR52_18350 ENOG4107QIV Cytochrome c biogenesis protein WR52_18360 ENOG4105CH2 amidohydrolase WR52_18370 ENOG4105CJ1 ABC, transporter WR52_18385 ENOG4107RSM transcriptional regulator WR52_18390 ENOG4105VAW lrga family WR52_18395 ENOG41067MG lrgb family WR52_18435 ENOG4105BZ1 (ABC) transporter WR52_18440 ENOG4105BZ1 (ABC) transporter WR52_18475 ENOG4108HW3 (ABC) transporter WR52_18480 ENOG4105CGH 5'-nucleotidase WR52_18490 ENOG4108SVB resolvase WR52_18510 ENOG4105K7K Transcriptional regulator WR52_18520 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase WR52_18525 ENOG4105DR5 peptidase WR52_18565 ENOG4105C5F glutamine synthetase WR52_18570 ENOG4105KV4 Transcriptional regulator WR52_18575 ENOG4105CXI aluminum resistance protein WR52_18580 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) WR52_18585 ENOG4105EN6 Membrane WR52_18595 ENOG4106F1P AAA ATPase, central domain protein WR52_18615 ENOG4105DQ6 Transposase WR52_18635 ENOG41069ER domain protein WR52_18640 ENOG4105DM4 PTS System WR52_18645 ENOG4105DE4 1-phosphofructokinase WR52_18650 ENOG4105E98 transcriptional regulator DeoR family WR52_18655 ENOG4107QW4 alcohol dehydrogenase WR52_18660 ENOG4108SJC Membrane WR52_18675 ENOG4105C85 amino acid WR52_18695 ENOG4105TMB Formate nitrite transporter WR52_18700 ENOG4105K70 DNA-binding protein WR52_18710 ENOG4105C59 p-type ATPase WR52_18715 ENOG410681U heavy metal transport detoxification protein WR52_18720 ENOG4105VPX protein, conserved in bacteria WR52_18730 ENOG4105NIV Esterase WR52_18735 ENOG4105E0A ABC, transporter WR52_18755 ENOG4105CGK Exodeoxyribonuclease III WR52_18765 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) WR52_18770 ENOG4105D03 DNA-3-methyladenine glycosylase II WR52_18800 ENOG4105BZU Histidine kinase WR52_18840 ENOG41067MG lrgb family WR52_18860 ENOG4108S3Y transcriptional regulator WR52_18865 ENOG4105CS2 ec 3.2.1.21 WR52_18880 ENOG4105F0V Cell wall hydrolase WR52_18890 ENOG4105E0M Sulfatase WR52_18895 ENOG410890F Dynamin family WR52_18925 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) WR52_18930 ENOG4105DQU oxidoreductase, subunit beta WR52_18935 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein WR52_18940 ENOG4108IGT Dipeptidase WR52_18945 ENOG4105MCT stage V sporulation protein S WR52_18950 ENOG4105D48 metallophosphoesterase WR52_18970 ENOG4105CEV competence damage-inducible protein WR52_18975 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase WR52_18990 ENOG4105XZV Protein of unknown function (DUF3243) WR52_18995 ENOG4108RKS Short-chain dehydrogenase reductase Sdr WR52_19015 ENOG4105UIB (ABC) transporter WR52_19020 ENOG4108JQ9 ABC transporter WR52_19025 ENOG4105DIH basic membrane WR52_19030 ENOG4105FDP GntR family transcriptional regulator WR52_19035 ENOG4105CNU cell division protein FtsK WR52_19045 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit WR52_19060 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) WR52_19070 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) WR52_19075 ENOG4108S0H Dipicolinic acid synthetase, b subunit WR52_19080 ENOG4108IBT Inherit from COG: transposase WR52_19215 ENOG4105DQ6 Transposase WR52_19230 ENOG41069ER domain protein WR52_19250 ENOG4105CDU Replicative dna helicase WR52_19285 ENOG41067QW Transcriptional regulator WR52_19315 ENOG4105E35 Dipicolinate synthase subunit A WR52_19325 ENOG4105C1V Peptidase, M16 WR52_19345 ENOG4105DTN riboflavin biosynthesis protein ribF WR52_19360 ENOG4105W7A Protein of unknown function (DUF503) WR52_19370 ENOG4105VHM ribosomal protein WR52_19375 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination WR52_19380 ENOG4105CHV Transcription elongation factor NusA WR52_19390 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) WR52_19395 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) WR52_19400 ENOG4105DZP Membrane-associated zinc metalloprotease WR52_19405 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) WR52_19410 ENOG4105KNE Phosphatidate cytidylyltransferase WR52_19415 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) WR52_19425 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) WR52_19455 ENOG4108HE4 integrase family WR52_19465 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) WR52_19470 ENOG4105C79 DNA protecting protein DprA WR52_19475 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha WR52_19490 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) WR52_19515 ENOG4105VB6 UPF0109 protein WR52_19535 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) WR52_19540 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) WR52_19555 ENOG4105CHR reductase WR52_19560 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase WR52_19575 ENOG4105CB5 ATP-dependent DNA helicase recG WR52_19580 ENOG4105DP4 dak2 domain fusion protein ylov WR52_19585 ENOG4108ZAA Alkaline-shock protein WR52_19600 ENOG4105FJ0 thiamine WR52_19605 ENOG4105DJV ribulose-phosphate 3-epimerase WR52_19610 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) WR52_19615 ENOG4105D9P serine threonine protein kinase WR52_19620 ENOG4108ZF3 Phosphatase WR52_19630 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B WR52_19645 ENOG4105C25 Primosomal protein n' WR52_19650 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase WR52_19670 ENOG4105DSJ YicC domain protein WR52_19680 ENOG4105F23 Fibronectin-binding protein WR52_19685 ENOG4105DC7 peptidase M24 WR52_19730 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) WR52_19765 ENOG4105C34 Pseudouridine synthase WR52_19780 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) WR52_19790 ENOG4105DBK s4 domain protein WR52_19795 ENOG41067XK integral membrane protein WR52_19805 ENOG4105DFA alanine racemase domain protein WR52_19810 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase WR52_19815 ENOG4105WR5 sporulation protein, YlmC YmxH family WR52_19825 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WR52_19835 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) WR52_19840 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) WR52_19850 ENOG4105D4A Cell wall formation (By similarity) WR52_19855 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) WR52_19860 ENOG4105CNI cell division protein FtsW WR52_19875 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) WR52_19880 ENOG4105CJN penicillin-binding protein WR52_19885 ENOG4105CJN penicillin-binding protein WR52_19900 ENOG41074B2 UPF0747 protein WR52_19925 ENOG4105KNH Nucleic acid-binding protein WR52_20035 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) WR52_20045 ENOG4105CAR Terminase, large subunit WR52_20080 ENOG4105CNU cell division protein FtsK WR52_20150 ENOG4105KRN Transcriptional regulator, abrb family WR52_20220 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) WR52_20230 ENOG41063PX domain protein WR52_20235 ENOG4105D78 K07001 NTE family protein WR52_20240 ENOG4105H20 Sporulation integral membrane protein YlbJ WR52_20250 ENOG4106H78 methyltransferase WR52_20270 ENOG4107TB6 phosphoglycerate mutase WR52_20285 ENOG4106UY4 Inherit from COG: Scp-like extracellular WR52_20335 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) WR52_20340 ENOG4105CNI cell division protein FtsW WR52_20355 ENOG4108IAB Phoh family WR52_20375 ENOG4105QA2 WR52_20380 ENOG4105CI3 gtp-binding protein typa WR52_20390 ENOG4105ECY inositol monophosphatase WR52_20410 ENOG4105CXN decarboxylase WR52_20460 ENOG4105CPP Dehydrogenase, E1 component WR52_20475 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) WR52_20480 ENOG4108X4Q Hydrolase WR52_20490 ENOG4105CN5 Metallo-Beta-Lactamase WR52_20495 ENOG4107ZYR domain protein WR52_20530 ENOG4108XRC Protein of unknown function (DUF458) WR52_20540 ENOG4107IN1 Protein of unknown function (DUF1797) WR52_20555 ENOG4105EPM Diguanylate phosphodiesterase WR52_20560 ENOG4105K6S Short-chain dehydrogenase reductase Sdr WR52_20575 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) WR52_20585 ENOG4105UIN WR52_20625 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) WR52_20645 ENOG4108HGU Histidine kinase WR52_20655 ENOG4105CHM Aminotransferase WR52_20660 ENOG4105FKQ transcriptional regulator WR52_20665 ENOG4105EG2 ABC transporter, permease WR52_20675 ENOG4107FKK extracellular solute-binding protein family 1 WR52_20685 ENOG4105CG3 alpha amylase, catalytic region WR52_20730 ENOG4105CHU acetyl-coa acetyltransferase WR52_20765 ENOG4105K7K Transcriptional regulator WR52_20770 ENOG4105DTD Dehydrogenase WR52_20790 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase WR52_20815 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) WR52_20830 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase WR52_20840 ENOG4105BZU Histidine kinase WR52_20860 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) WR52_20875 ENOG4105CID antiterminator WR52_20885 ENOG4105FDP GntR family transcriptional regulator WR52_20895 ENOG4105CE4 GlcNAc 6-P deacetylase WR52_20935 ENOG4107ZE5 PPIases accelerate the folding of proteins WR52_20940 ENOG4105PTM secreted protein WR52_20945 ENOG4105J7I hydrolase WR52_20955 ENOG4105G6R Stage v sporulation protein ae WR52_20965 ENOG4105CZ3 stage V sporulation protein ad WR52_20970 ENOG41090VF Stage v sporulation protein ac WR52_20990 ENOG4105C8J )-transporter WR52_20995 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WR52_21005 ENOG41082AN stage II sporulation protein WR52_21010 ENOG4105DZ1 carboxypeptidase WR52_21015 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family WR52_21020 ENOG4105DVE abc transporter atp-binding protein WR52_21055 ENOG4105D7N magnesium and cobalt transport protein CorA WR52_21080 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) WR52_21090 ENOG4105I3K Ferric uptake regulator, Fur family WR52_21095 ENOG4105MZ9 stage II sporulation protein m WR52_21115 ENOG4105CPC Aldo Keto reductase WR52_21125 ENOG4105RHY Pfam:UPF0157 WR52_21145 ENOG4107SKW Inherit from COG: Alpha beta hydrolase WR52_21155 ENOG4105ETE Transcriptional regulator (LacI family WR52_21160 ENOG4108YM7 Gcn5-related n-acetyltransferase WR52_21180 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) WR52_21185 ENOG4108R6K riboflavin synthase, subunit alpha WR52_21210 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) WR52_21215 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) WR52_21230 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) WR52_21240 ENOG4105DFD Na H antiporter WR52_21245 ENOG4105CGH 5'-nucleotidase WR52_21270 ENOG4105DBV ornithine carbamoyltransferase WR52_21285 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) WR52_21300 ENOG4108IXY short-chain dehydrogenase reductase WR52_21305 ENOG41069FQ Metallo-beta-lactamase superfamily WR52_21310 ENOG4105II7 pyrroline-5-carboxylate reductase WR52_21315 ENOG4105DQ6 Transposase WR52_21325 ENOG4105EJQ L-serine dehydratase WR52_21370 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) WR52_21375 ENOG4105D9U N-acetyltransferase WR52_21390 ENOG4108VZI ErfK ybiS ycfS ynhG family protein WR52_21395 ENOG4108QEG Membrane WR52_21400 ENOG4105CDA abc transporter atp-binding protein WR52_21405 ENOG4105E5Q amino acid AbC transporter WR52_21410 ENOG4108HW3 (ABC) transporter WR52_21420 ENOG4105G7B Protein of unknown function (DUF2992) WR52_21445 ENOG4105C7S Dehydrogenase WR52_21450 ENOG4105CPP Dehydrogenase, E1 component WR52_21465 ENOG4105CKM Branched-chain carboxylic acid kinase WR52_21470 ENOG4107RDP Dehydrogenase WR52_21485 ENOG4108JUB Transcriptional regulator WR52_21495 ENOG4108QXE glycerophosphoryl diester phosphodiesterase WR52_21510 ENOG4107QQR Sporulation WR52_21520 ENOG4105S1Z Stage IV sporulation protein B WR52_21525 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) WR52_21530 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) WR52_21535 ENOG4105DX0 Hemolysin A WR52_21545 ENOG4105CTB Polyprenyl synthetase WR52_21560 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) WR52_21570 ENOG4108ZSR alkaline shock protein WR52_21575 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase WR52_21600 ENOG410644B Stage III sporulation protein af WR52_21610 ENOG4105KQ4 Stage iii sporulation protein ad WR52_21615 ENOG4108CQH stage III sporulation protein AC WR52_21620 ENOG4105KR5 Stage iii sporulation protein WR52_21625 ENOG4105CD2 stage iii sporulation protein aa WR52_21650 ENOG4105DC7 peptidase M24 WR52_21655 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) WR52_21665 ENOG4105CBJ Metal-dependent enzyme WR52_21675 ENOG4107YBY Hydrolase WR52_21690 ENOG4105K7K Transcriptional regulator WR52_21705 ENOG41082GG biotin lipoate A B protein ligase WR52_21710 ENOG4105WZW rhodanese family WR52_21735 ENOG41080TC multidrug resistance protein WR52_21770 ENOG4105CJ1 ABC, transporter WR52_21775 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family WR52_21805 ENOG4105C0D helicase WR52_21890 ENOG4107R6U sodium dicarboxylate symporter WR52_21930 ENOG4105C3R Methionine synthase WR52_21940 ENOG4105C28 cystathionine WR52_21945 ENOG4105C28 cystathionine WR52_21965 ENOG4105C5X domain protein WR52_21975 ENOG4105DKQ ROK family WR52_21985 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase WR52_22000 ENOG4105DQ6 Transposase WR52_22010 ENOG4108UTW Plays a role in the regulation of phosphate uptake WR52_22015 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) WR52_22020 ENOG4105C8U phosphate abc transporter WR52_22025 ENOG4105C8U phosphate abc transporter WR52_22030 ENOG4105EXS phosphate abc transporter WR52_22035 ENOG4107RF6 penicillin-binding protein WR52_22045 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) WR52_22070 ENOG4105N80 Ferric uptake regulator, Fur family WR52_22080 ENOG4105FDK ABC transporter WR52_22085 ENOG4108JYZ YitT family WR52_22090 ENOG41069ZM Protein of unknown function (DUF2624) WR52_22115 ENOG4105EGD dinuclear metal center protein, YbgI family WR52_22130 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WR52_22135 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) WR52_22165 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) WR52_22170 ENOG4105KG3 cytidine deaminase WR52_22175 ENOG4107YR5 Diacylglycerol kinase WR52_22185 ENOG4105CTJ Metal Dependent Phosphohydrolase WR52_22190 ENOG4105C9A Phoh family WR52_22200 ENOG41068P3 sporulation protein YqfC WR52_22210 ENOG4105KTH gatB Yqey WR52_22220 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) WR52_22225 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) WR52_22255 ENOG4105CSA Coproporphyrinogen iii oxidase WR52_22260 ENOG4105KVH Transcriptional regulator WR52_22285 ENOG4105TQK DNA polymerase iii, delta' subunit WR52_22295 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 WR52_22300 ENOG4108UK2 deaminase WR52_22305 ENOG4105KQC Competence protein WR52_22315 ENOG4105DXX methyltransferase WR52_22325 ENOG4108WF2 Metal Dependent Phosphohydrolase WR52_22335 ENOG410812S Rna-binding protein WR52_22345 ENOG4105CQW ribosome biogenesis GTPase YqeH WR52_22350 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase WR52_22365 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WR52_22385 ENOG4108TVJ Nitroreductase WR52_22400 ENOG4105G6Z alkaline phosphatase WR52_22405 ENOG4105KEG ribosomal-protein-alanine acetyltransferase WR52_22410 ENOG4108MUZ hydrolase WR52_22455 ENOG4105DQ6 Transposase WR52_22470 ENOG4105MIR Phenylalanine 4-monooxygenase WR52_22480 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase WR52_22520 ENOG4105S6R Iron-hydroxamate transporter permease subunit WR52_22525 ENOG4108V5C ABC transporter WR52_22535 ENOG4108EKI Dehydrogenase WR52_22540 ENOG4105C28 cystathionine WR52_22570 ENOG4107XRG penicillin-binding protein WR52_22580 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) WR52_22590 ENOG4105CFP Peptidase U32 WR52_22595 ENOG4105XYU peptidase (U32 family) WR52_22600 ENOG4108VQJ O-methyltransferase WR52_22605 ENOG4105HHA aminodeoxychorismate lyase WR52_22625 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) WR52_22635 ENOG4105C02 permease WR52_22650 ENOG41060CR WR52_22655 ENOG4105C7H Helicase, RecD TraA family WR52_22665 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) WR52_22670 ENOG4105C3J Cysteine desulfurase WR52_22680 ENOG4105D1H recombination factor protein RarA WR52_22685 ENOG4108VCI transcription factor, rsfa family WR52_22700 ENOG4105CUZ uba thif-type nad fad binding protein WR52_22710 ENOG4105CUT histidyl-tRNA synthetase WR52_22720 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) WR52_22725 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) WR52_22735 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) WR52_22740 ENOG41076HS cation diffusion facilitator family transporter WR52_22745 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) WR52_22755 ENOG4105CKP Polysaccharide Biosynthesis Protein WR52_22760 ENOG4108QG2 Membrane WR52_22770 ENOG4105VIE preprotein translocase, subunit YajC WR52_22785 ENOG41061AI Protein of unknown function (DUF2905) WR52_22800 ENOG4108HUF Transporter WR52_22830 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase WR52_22835 ENOG4108IYU L-aspartate oxidase WR52_22850 ENOG4108RPX mosc domain containing protein WR52_22855 ENOG4105CQC Prephenate dehydratase WR52_22875 ENOG4105EWM Histidine kinase WR52_22885 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control WR52_22900 ENOG4105X36 (ribosomal) protein WR52_22910 ENOG4105C03 ribonuclease WR52_22925 ENOG4107QMS site-determining protein WR52_22940 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) WR52_22945 ENOG4105DFF Rod shape-determining protein mreb WR52_22965 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase WR52_22970 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) WR52_22980 ENOG41068KH stage VI sporulation protein D WR52_22990 ENOG4105D52 delta-aminolevulinic acid dehydratase WR52_23015 ENOG4105K56 Transcriptional regulator WR52_23035 ENOG4108IUQ atp-dependent protease WR52_23060 ENOG4108QCI YvbH-like oligomerisation region WR52_23080 ENOG4105M59 Phosphodiesterase, mj0936 family WR52_23085 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) WR52_23095 ENOG4108XJQ germination protein WR52_23105 ENOG4108PCX Major Facilitator WR52_23115 ENOG4105KBX Transcriptional regulator, TetR family WR52_23125 ENOG4105PFC Transcriptional regulator WR52_23135 ENOG4105DZC cytosine deaminase WR52_23140 ENOG41067S9 phage shock protein C, PspC WR52_23145 ENOG4108JCI Transcriptional regulator WR52_23155 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) WR52_23160 ENOG4108Z40 Transcriptional regulator WR52_23165 ENOG4105RHA ABC transporter, permease WR52_23170 ENOG4108IUX (ABC) transporter WR52_23175 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family WR52_23180 ENOG4105ER2 Ompa motb domain protein WR52_23185 ENOG4105E14 MotA TolQ exbB proton channel WR52_23190 ENOG4108VXD carboxy-peptidase WR52_23200 ENOG4105E33 succinate dehydrogenase WR52_23210 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit WR52_23220 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) WR52_23225 ENOG4105K63 Thioredoxin WR52_23230 ENOG4105C10 Electron transfer flavoprotein WR52_23235 ENOG4105BZJ Electron transfer flavoprotein WR52_23240 ENOG41060WC Enoyl-CoA hydratase WR52_23245 ENOG4107Z3H Transcriptional regulator, TetR family WR52_23250 ENOG4105CEY Amp-dependent synthetase and ligase WR52_23260 ENOG4105J76 Periplasmic binding protein WR52_23265 ENOG4105S6R Iron-hydroxamate transporter permease subunit WR52_23320 ENOG4105DPZ Two component transcriptional regulator (Winged helix family WR52_23335 ENOG4105DR4 Methyltransferase WR52_23345 ENOG4105KFN sortase, SrtB family WR52_23350 ENOG4105E0A ABC, transporter WR52_23365 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) WR52_23375 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) WR52_23385 ENOG4105FE9 pseudouridine synthase WR52_23400 ENOG4105DCG PHP domain protein WR52_23415 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) WR52_23435 ENOG4105C5S asparaginyl-tRNA synthetase WR52_23440 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) WR52_23450 ENOG4108RWN rrna methyltransferase WR52_23475 ENOG4105C0R drug resistance transporter emrb qaca subfamily WR52_23480 ENOG4105CW7 secretion protein, HlyD family WR52_23485 ENOG4108JGH Tetr family transcriptional regulator WR52_23490 ENOG4105CN9 Peptidase m42 family protein WR52_23510 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) WR52_23515 ENOG4105C22 threonyL-tRNA synthetase WR52_23520 ENOG4108TDW sporulation protein YtxC WR52_23545 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) WR52_23550 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase WR52_23555 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) WR52_23565 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) WR52_23570 ENOG4105C2M dna polymerase I WR52_23575 ENOG4105BZU Histidine kinase WR52_23580 ENOG4105DPZ Two component transcriptional regulator (Winged helix family WR52_23590 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) WR52_23595 ENOG4108HMX isocitrate dehydrogenase (NADP) WR52_23600 ENOG4105BZN citrate synthase WR52_23615 ENOG4108REF Sporulation integral membrane protein ytvi WR52_23620 ENOG4105FS0 cytoplasmic membrane protein WR52_23645 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family WR52_23650 ENOG4105C6K Malic enzyme WR52_23655 ENOG4105C0B DNA polymerase III (alpha subunit) WR52_23660 ENOG4105VV2 WR52_23670 ENOG4105SFS phosphoesterase RecJ domain protein WR52_23700 ENOG4105DC7 peptidase M24 WR52_23730 ENOG4105Z7P Acetyltransferase (GNAT) family WR52_23735 ENOG41082W1 Cupin 2, conserved barrel domain protein WR52_23755 ENOG4107YZX Universal stress protein WR52_23795 ENOG4108JYZ YitT family WR52_23815 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) WR52_23825 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) WR52_23830 ENOG4105KBJ sporulation protein ytfj WR52_23845 ENOG4105EFZ amidohydrolase WR52_23855 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) WR52_23880 ENOG4105RQF LysR family Transcriptional regulator WR52_23890 ENOG4105U5Y Transcriptional regulator WR52_23900 ENOG4105C28 cystathionine WR52_23910 ENOG4108IBT Inherit from COG: transposase WR52_23935 ENOG4108UW5 maltose o-acetyltransferase WR52_23945 ENOG4105F1V Acetoin utilization protein WR52_23950 ENOG4105W87 Cbs domain WR52_23955 ENOG4105DGU Histone deacetylase WR52_23970 ENOG4105DPZ Two component transcriptional regulator (Winged helix family WR52_23980 ENOG4107SNB ankyrin repeat protein YahD WR52_23985 ENOG4105EP9 oxidoreductase WR52_24010 ENOG4105ETE Transcriptional regulator (LacI family WR52_24020 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase WR52_24040 ENOG4105C88 aminopeptidase WR52_24070 ENOG4108IPJ Membrane WR52_24095 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase WR52_24105 ENOG4108VDD TRNA binding domain protein WR52_24135 ENOG4105C8F Beta-lactamase domain protein WR52_24150 ENOG4108V15 phosphotransferase enzyme family WR52_24155 ENOG4108IUM Glycogen debranching enzyme WR52_24165 ENOG4107QSE Dipeptidase WR52_24170 ENOG4105YW5 deoR family transcriptional regulator WR52_24185 ENOG4105CBX hi0933 family WR52_24225 ENOG4108VJ1 Transcriptional regulator (CarD family WR52_24230 ENOG4107EXU Short-chain dehydrogenase reductase Sdr WR52_24235 ENOG4105CSC Glucose uptake protein WR52_24250 ENOG4108ZAF Molybdopterin WR52_24255 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein WR52_24260 ENOG4105CVM Molybdenum cofactor synthesis domain protein WR52_24270 ENOG4105D06 uba thif-type nad fad binding protein WR52_24275 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) WR52_24295 ENOG41085GJ domain protein WR52_24305 ENOG4105DWV Homoserine O-trans-acetylase WR52_24315 ENOG4108B31 Spore germination protein WR52_24340 ENOG4105C8T Leucyl-tRNA synthetase WR52_24345 ENOG410605W Major Facilitator WR52_24350 ENOG4107S91 Sodium hydrogen exchanger WR52_24355 ENOG4105NCW Trka-c domain protein WR52_24370 ENOG4105C19 ABC transporter WR52_24390 ENOG4105N5T Radical SAM Protein WR52_24420 ENOG4105E8V Alpha Beta Hydrolase Fold protein WR52_24425 ENOG4108Z0R Transferase WR52_24430 ENOG4105YVM Phosphoesterase, PA-phosphatase related WR52_24435 ENOG4105BZF Glycosyl transferase (Group 1 WR52_24445 ENOG4105EPU Molybdenum cofactor synthesis domain protein WR52_24520 ENOG4105BZU Histidine kinase WR52_24525 ENOG4105BZU Histidine kinase WR52_24535 ENOG4107S9D Alpha beta hydrolase WR52_24540 ENOG4107T7U Sulfatase WR52_24560 ENOG4105D2X ABC transporter substrate-binding protein WR52_24570 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component WR52_24640 ENOG4108V2W Carbonate dehydratase WR52_24645 ENOG4105D7V transposase WR52_24650 ENOG4105C4M (Ubiquinol oxidase) subunit I WR52_24655 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii WR52_24690 ENOG41087YS Phage shock protein A WR52_24720 ENOG4105BZU Histidine kinase WR52_24725 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR52_24750 ENOG4108UGV hypoxanthine phosphoribosyltransferase WR52_24755 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) WR52_24790 ENOG4107ZTW SNARE associated Golgi WR52_24805 ENOG4105C19 ABC transporter WR52_24810 ENOG41086D8 Transcriptional regulator WR52_24825 ENOG41082BM Transcriptional regulator, arsr family WR52_24865 ENOG4105C6Z Gluconate WR52_24870 ENOG4105FDP GntR family transcriptional regulator WR52_24890 ENOG41069H0 dihydroorotase EC 3.5.2.3 WR52_24910 ENOG4105DTQ mandelate racemase muconate lactonizing WR52_24915 ENOG4105CEY Amp-dependent synthetase and ligase WR52_24925 ENOG4108IPT Naphthoate synthase WR52_24935 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) WR52_24940 ENOG4105E4F Isochorismate synthase WR52_24945 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase WR52_24955 ENOG4105VEQ Cold shock protein WR52_24995 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) WR52_25100 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation WR52_25140 ENOG4107PBV potassium channel WR52_25170 ENOG4105WG9 Conserved Protein WR52_25180 ENOG4105CHM Aminotransferase WR52_25185 ENOG4108ZB6 transcriptional regulator AsnC family WR52_25190 ENOG4105C5I Dehydrogenase WR52_25195 ENOG4108MUZ hydrolase WR52_25205 ENOG4105C87 Aminotransferase class I and II WR52_25220 ENOG4105Y38 Kinase-associated protein B WR52_25230 ENOG4107R3E Citrate transporter WR52_25245 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) WR52_25250 ENOG4105KA0 thioesterase Superfamily protein WR52_25265 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase WR52_25285 ENOG41069ER domain protein WR52_25300 ENOG4105CEP NADH dehydrogenase WR52_25330 ENOG4105EWC Purine nucleoside phosphorylase WR52_25340 ENOG4108VQJ O-methyltransferase WR52_25350 ENOG4108YX9 iron--sulfur cluster insertion protein erpA WR52_25375 ENOG4108JJA ABC, transporter WR52_25380 ENOG4105C4B ABC transporter, permease WR52_25385 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA WR52_25425 ENOG41083MR nifu domain-containing protein WR52_25440 ENOG4108W5N phosphatidylglycerophosphatase a WR52_25450 ENOG4105DYS nad(p)h dehydrogenase (quinone) WR52_25460 ENOG4105D4U had-superfamily hydrolase, subfamily iia WR52_25475 ENOG4105CBT Fructose-1,6-bisphosphatase WR52_25500 ENOG4105MMD transcriptional regulator WR52_25505 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) WR52_25510 ENOG4107TXC Transcriptional regulator WR52_25515 ENOG41090T1 Membrane WR52_25540 ENOG4105FAA peptidase M23 WR52_25545 ENOG4108YTE sporulation protein YunB WR52_25550 ENOG4105KZD Domain of unknown function (DUF1805) WR52_25555 ENOG4107R8B 5'-nucleotidase WR52_25560 ENOG4105DIW FeS assembly protein SUFB WR52_25565 ENOG4108UNV SUF system FeS assembly protein, NifU family WR52_25570 ENOG4105C9B Cysteine desulfurase WR52_25575 ENOG4105JRK feS assembly protein SufD WR52_25580 ENOG4105C3K feS assembly ATPase SufC WR52_25585 ENOG4105D01 (LipO)protein WR52_25590 ENOG4105D01 (LipO)protein WR52_25595 ENOG4108UMI ABC transporter, permease WR52_25600 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) WR52_25625 ENOG41080E8 Transcriptional regulator, Spx MgsR family WR52_25645 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) WR52_25670 ENOG4108W8B Beta-lactamase domain protein WR52_25675 ENOG4105C1G acyl-Coa dehydrogenase WR52_25685 ENOG4105CHU acetyl-coa acetyltransferase WR52_25700 ENOG4105DZ1 carboxypeptidase WR52_25720 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer WR52_25735 ENOG4108SUT Major Facilitator Superfamily WR52_25740 ENOG4107R7I amino acid WR52_25755 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins WR52_25765 ENOG4107AYK membrAne WR52_25800 ENOG4107ZTW SNARE associated Golgi WR52_25810 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein WR52_25815 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR52_25820 ENOG4105BZU Histidine kinase WR52_25835 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) WR52_25850 ENOG4105C8Q Methyl-accepting chemotaxis WR52_25855 ENOG4105VG1 fes assembly suf system protein WR52_25860 ENOG4105D4Y metalloprotease WR52_25880 ENOG4107T5V SNARE associated Golgi WR52_25885 ENOG4107S91 Sodium hydrogen exchanger WR52_25890 ENOG4105NCW Trka-c domain protein WR52_25910 ENOG4108RMU ferritin dps family protein WR52_25925 ENOG4108URH decarboxylase WR52_25935 ENOG41090A1 ferritin WR52_25945 ENOG4105D9N nucleoside WR52_25950 ENOG4105D9N nucleoside WR52_25965 ENOG4108RYK Nad-dependent epimerase dehydratase WR52_25980 ENOG4105CV8 reductase WR52_25985 ENOG4105F27 Major Facilitator WR52_25990 ENOG4105KVH Transcriptional regulator WR52_26005 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) WR52_26010 ENOG4105D4A Cell wall formation (By similarity) WR52_26030 ENOG4105WMR Protein CrcB homolog WR52_26035 ENOG4105WMR Protein CrcB homolog WR52_26055 ENOG4105C5H ABC transporter WR52_26060 ENOG4108MK9 spermidine N(1)-acetyltransferase WR52_26070 ENOG4108VY7 phosphate-starvation-inducible protein PsiE WR52_26095 ENOG4108IPW abc transporter atp-binding protein WR52_26100 ENOG4105CM4 permease protein WR52_26130 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) WR52_26140 ENOG4105XZU Preprotein translocase, subunit SecG WR52_26145 ENOG41067MG lrgb family WR52_26195 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WR52_26215 ENOG41090VF Stage v sporulation protein ac WR52_26220 ENOG4105CZ3 stage V sporulation protein ad WR52_26235 ENOG4108QY0 Membrane WR52_26240 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) WR52_26245 ENOG4105KRI phosphocarrier protein (HPr WR52_26255 ENOG4105CHW UPF0052 protein WR52_26260 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) WR52_26265 ENOG4108Z4K mutator MutT protein WR52_26275 ENOG4105C3M thioredoxin reductase WR52_26285 ENOG4108S4C acetyltransferase WR52_26295 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) WR52_26305 ENOG41086DT Membrane protein of unknown function WR52_26315 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) WR52_26320 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) WR52_26340 ENOG4107TXC Transcriptional regulator WR52_26360 ENOG4105DUM transcriptional regulator, lysR family WR52_26370 ENOG4108WS4 fmn reductase WR52_26375 ENOG4105C5H ABC transporter WR52_26385 ENOG4105BZ1 (ABC) transporter WR52_26395 ENOG4105CN1 protease WR52_26400 ENOG4105CRP Part of the ABC transporter FtsEX involved in WR52_26405 ENOG4105CAK Cell division ATP-binding protein ftsE WR52_26420 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) WR52_26435 ENOG4108RDQ ABC transporter WR52_26465 ENOG4105MS2 ribosomal subunit Interface protein WR52_26470 ENOG4105VEQ Cold shock protein WR52_26475 ENOG41081UC Inherit from COG: Competence protein WR52_26490 ENOG4105KVH Transcriptional regulator WR52_26500 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein WR52_26505 ENOG4108KGH TRANSCRIPTIONal WR52_26510 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase WR52_26515 ENOG4105C6Y Udp-glucose 6-dehydrogenase WR52_26520 ENOG4105ESV Glycosyl transferase, family 4 WR52_26530 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family WR52_26550 ENOG4105F8D glycoside hydrolase family 4 WR52_26555 ENOG4105VCP PTS System WR52_26560 ENOG4105CK1 PTS System WR52_26570 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) WR52_26580 ENOG4105VCP PTS System WR52_26590 ENOG4105VZJ PTS System WR52_26610 ENOG4105ECB domain protein WR52_26615 ENOG4107RSM transcriptional regulator WR52_26645 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) WR52_26650 ENOG4105DAA L-lactate WR52_26660 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) WR52_26670 ENOG4105E0M Sulfatase WR52_26695 ENOG4107R8N Glycosyl transferase, family 2 WR52_26705 ENOG4105C94 Transporter WR52_26710 ENOG41069ER domain protein WR52_26735 ENOG4105KBK Zinc finger, swim domain protein WR52_26740 ENOG4105C0D helicase WR52_26770 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WR52_26780 ENOG4107RBB ABC transporter, permease WR52_26785 ENOG4105C19 ABC transporter WR52_26795 ENOG4105CXY transporter WR52_26810 ENOG4105BZU Histidine kinase WR52_26815 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR52_26820 ENOG4105CMR udp-glucose 4-epimerase WR52_26825 ENOG4105CMR udp-glucose 4-epimerase WR52_26835 ENOG4108KGH TRANSCRIPTIONal WR52_26845 ENOG4105CG5 Glycosyl transferase (Group 1 WR52_26865 ENOG4105CG5 Glycosyl transferase (Group 1 WR52_26875 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) WR52_26880 ENOG4105C6Y Udp-glucose 6-dehydrogenase WR52_26885 ENOG4105D3Q Sugar transferase WR52_26890 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase WR52_26895 ENOG4108RB3 Capsular polysaccharide biosynthesis protein WR52_26900 ENOG4107YJ4 chain length determinant protein WR52_26905 ENOG4105HTX biosynthesis protein WR52_26910 ENOG4107YJ4 chain length determinant protein WR52_26925 ENOG4105MT0 Sporulation transcriptional regulator spoiiid WR52_26935 ENOG4105FRN stage II sporulation protein WR52_26950 ENOG4105DY9 regulatoR WR52_26970 ENOG4106778 Protein of unknown function (DUF1146) WR52_26975 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) WR52_26980 ENOG4105C8S subunit m WR52_26985 ENOG4105D65 subunit l WR52_27010 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) WR52_27015 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain WR52_27025 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain WR52_27030 ENOG4105BZU Histidine kinase WR52_27080 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) WR52_27085 ENOG41062M3 atp synthase WR52_27105 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) WR52_27110 ENOG4108UIC UPF0340 protein WR52_27115 ENOG4108YZG isomerase WR52_27130 ENOG4108VGI doxx family WR52_27135 ENOG4107XC4 flavin reductase domain protein, FMN-binding WR52_27150 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) WR52_27160 ENOG4108ZXQ stage ii sporulation protein r WR52_27165 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) WR52_27170 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) WR52_27175 ENOG4107104 thymidine kinase WR52_27185 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) WR52_27190 ENOG4105CBT Fructose-1,6-bisphosphatase WR52_27195 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) WR52_27215 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) WR52_27230 ENOG4105C1G acyl-Coa dehydrogenase WR52_27235 ENOG4105C1G acyl-Coa dehydrogenase WR52_27240 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase WR52_27250 ENOG4105DF6 Fe-S oxidoreductase WR52_27265 ENOG4105BZU Histidine kinase WR52_27280 ENOG4105D4Y metalloprotease WR52_27290 ENOG4105BZU Histidine kinase WR52_27295 ENOG4105KCT ABC transporter WR52_27300 ENOG4108M15 ABC transporter WR52_27305 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) WR52_27315 ENOG4105IIU Aminopeptidase WR52_27345 ENOG410684U Domain of unknown function (DUF1934) WR52_27365 ENOG4105CYW agmatinase WR52_27375 ENOG4105DXB Major Facilitator superfamily WR52_27380 ENOG4107SWG transcriptional regulator MERR family WR52_27385 ENOG4108QXE glycerophosphoryl diester phosphodiesterase WR52_27390 ENOG4105BZ4 penicillin-binding protein WR52_27395 ENOG4108XFG YwhD family WR52_27400 ENOG4108Z4T Peptidase M50 WR52_27405 ENOG41069HH 4-oxalocrotonate tautomerase WR52_27410 ENOG4105DCI Phosphohydrolase WR52_27415 ENOG4108MES Periplasmic binding protein WR52_27420 ENOG4105E0A ABC, transporter WR52_27425 ENOG4105EHG Permease protein WR52_27430 ENOG4105DQ5 transport system permease protein WR52_27440 ENOG4108VCI transcription factor, rsfa family WR52_27445 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) WR52_27450 ENOG4108IJ2 phosphate acetyltransferase WR52_27455 ENOG4107UEZ chlorite dismutase WR52_27465 ENOG4108VKI Cell wall hydrolase WR52_27485 ENOG4107SVH Potassium channel protein WR52_27495 ENOG410667J hydrolase WR52_27500 ENOG4105VCH membrane WR52_27510 ENOG4108TU7 Inherit from COG: (ABC) transporter WR52_27515 ENOG4105CJ1 ABC, transporter WR52_27520 ENOG41090WU lipolytic protein G-D-S-L family WR52_27535 ENOG4105D6E homoserine dehydrogenase WR52_27560 ENOG4108Y4K DNA-binding transcriptional activator WR52_27570 ENOG4105WH1 Two component transcriptional regulator luxr family WR52_27575 ENOG4105BZU Histidine kinase WR52_27580 ENOG4105DWF phosphomethylpyrimidine kinase WR52_27585 ENOG4105BZU Histidine kinase WR52_27590 ENOG4105VCD cytoplasmic protein WR52_27595 ENOG4105D22 carbon starvation protein WR52_27600 ENOG4105DY9 regulatoR WR52_27605 ENOG41079KZ Major Facilitator Superfamily WR52_27615 ENOG4105CG5 Glycosyl transferase (Group 1 WR52_27625 ENOG4105EN6 Membrane WR52_27630 ENOG4106YBV Methyl-accepting chemotaxis WR52_27640 ENOG4108S4H thioesterase Superfamily protein WR52_27645 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) WR52_27655 ENOG4105K64 Glycosyl transferase, family 2 WR52_27675 ENOG4105C5H ABC transporter WR52_27680 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein WR52_27690 ENOG41067SE Tetr family transcriptional regulator WR52_27700 ENOG4105E0X reductase WR52_27705 ENOG4106F5Q Membrane WR52_27720 ENOG4108NEV two component transcriptional regulator, LytTR family WR52_27725 ENOG4108HRK Histidine kinase WR52_27730 ENOG4107RGD Major Facilitator superfamily WR52_27745 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) WR52_27755 ENOG4105IW1 AmiS UreI transporter WR52_27760 ENOG4105CMR udp-glucose 4-epimerase WR52_27765 ENOG4108UT2 hemolysin iii WR52_27775 ENOG4105C1J atp-dependent rna helicase WR52_27780 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) WR52_27785 ENOG4105DPN Oligoendopeptidase f WR52_27805 ENOG4105C0H protease WR52_27810 ENOG4105Q2H domain protein WR52_27825 ENOG4105BZU Histidine kinase WR52_27830 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR52_27855 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis WR52_27860 ENOG4105CDU Replicative dna helicase WR52_27870 ENOG4105BZR domain protein WR52_27875 ENOG4108XMW Membrane WR52_27885 ENOG4108UUM single-stranded DNA-binding protein WR52_27895 ENOG4105C3G gtp-binding protein WR52_27900 ENOG4105VDK protein, conserved in bacteria WR52_27905 ENOG4105D8X mechanosensitive ion channel WR52_27910 ENOG4108ZDA Sporulation protein YyaC WR52_27915 ENOG4105FA0 parb-like partition protein WR52_27920 ENOG4107QJE Chromosome Partitioning Protein WR52_27935 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) WR52_27940 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) WR52_27950 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins WR52_28015 ENOG4107SET aldo keto reductase WR52_28055 ENOG4105D7V transposase WR52_28070 ENOG4105ETE Transcriptional regulator (LacI family WR52_28075 ENOG4105IE8 Alpha-ketoglutarate permease WR52_28085 ENOG4105CK5 oxidoreductase WR52_28110 ENOG4105D2N Aldolase WR52_28115 ENOG4105DH8 myo-inositol catabolism WR52_28150 ENOG41068JE domain protein WR52_28230 ENOG4105E1K spore germination protein WR52_28240 ENOG4105D7V transposase WR52_28255 ENOG4108M1A Chitin-binding protein WR52_28260 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C WR52_28295 ENOG4108QXE glycerophosphoryl diester phosphodiesterase WR52_28310 ENOG4105CEP NADH dehydrogenase WR52_28345 ENOG4105D7V transposase WR52_28360 ENOG4105FAW cDP-glucose 4,6-dehydratase WR52_28365 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase WR52_28390 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase WR52_28450 ENOG4105CKK Glycosyl transferase, family 2 WR52_28475 ENOG4108MEK Metal-binding protein YodA WR52_28490 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) WR52_28535 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin WR52_28575 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WR52_28605 ENOG4105CP9 extracellular ligand-binding receptor WR52_28610 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) WR52_28620 ENOG4108JPW Aminotransferase WR52_28640 ENOG4105DQ6 Transposase WR52_28650 ENOG4105FQP Beta-lactamase WR52_28680 ENOG4105ED2 Beta-lactamase WR52_28705 ENOG4105MZU cell filamentation protein WR52_28715 ENOG4105EQ0 Major Facilitator superfamily WR52_28720 ENOG4108JGH Tetr family transcriptional regulator WR52_28735 ENOG4105C44 Serine transporter WR52_28740 ENOG4105EJQ L-serine dehydratase WR52_28755 ENOG4105DVH amino acid WR52_28835 ENOG4105CHR reductase WR52_28840 ENOG4105D7V transposase WR52_28865 ENOG4105E09 nadh pyrophosphatase WR52_28870 ENOG4107TVC Glycosyl transferase, family 2 WR52_28935 ENOG4105D7V transposase WR52_29020 ENOG4108IAJ Nad-dependent epimerase dehydratase WR52_29025 ENOG4107SBE Glycosyl transferase (Group 1 WR52_29045 ENOG4107SBE Glycosyl transferase (Group 1 WR52_29050 ENOG4108KS4 Spore coat protein WR52_29075 ENOG4108QY0 Membrane WR52_29080 ENOG41069DP small acid-soluble spore protein WR52_29085 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase WR52_29090 ENOG4108R5S membrane WR52_29125 ENOG4105D7V transposase WR52_29145 ENOG41087PP glycosyltransferase MGT family WR52_29150 ENOG4105KNA -acetyltransferase WR52_29205 ENOG4105KRN Transcriptional regulator, abrb family WR52_29270 ENOG4108VQT Alpha beta hydrolase fold protein WR52_29290 ENOG4105CMG Carbohydrate kinase WR52_29300 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) WR52_29450 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase WR52_29520 ENOG4108IBT Inherit from COG: transposase WR52_29545 ENOG4108IMY Transcriptional regulator WR52_29555 ENOG4107VMI polysaccharide deacetylase WR52_29570 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase WR52_29625 ENOG4105DQ6 Transposase WR52_29665 ENOG4105W5Q DNA repair protein (RadC WR52_29695 ENOG4108IBT Inherit from COG: transposase WR52_29735 ENOG4105D7V transposase WR52_29750 ENOG4105E39 Enoyl-CoA hydratase WR52_29760 ENOG4105K64 Glycosyl transferase, family 2 WR52_29770 ENOG4108UT6 Transferase hexapeptide repeat containing protein WR52_29795 ENOG4108IMY Transcriptional regulator WR52_29820 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr WR52_29825 ENOG4105D2T synthase WR52_29840 ENOG4105CHR reductase WR52_29855 ENOG4105C5E polysaccharide biosynthesis protein WR52_29860 ENOG4105C1B dTDP-glucose 4-6-dehydratase WR52_29865 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase WR52_29870 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) WR52_29920 ENOG410682Q Phage transcriptional regulator, ArpU WR52_29935 ENOG41067QW Transcriptional regulator WR52_29980 ENOG4107QJE Chromosome Partitioning Protein WR52_30060 ENOG410905X membrane-flanked domain protein WR52_30075 ENOG4105C19 ABC transporter WR52_30080 ENOG4107RBB ABC transporter, permease WR52_30090 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family WR52_30115 ENOG41067XF inhibitor WR52_30145 ENOG4107QJE Chromosome Partitioning Protein WR52_30180 ENOG4105DQ6 Transposase WR52_30215 ENOG4105WH1 Two component transcriptional regulator luxr family WR52_30235 ENOG4105BZU Histidine kinase WR52_30290 ENOG4105D3R alkyl hydroperoxide reductase WR52_30295 ENOG4108IQI permease WR52_30305 ENOG4105CXN decarboxylase WR52_30310 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein WR52_30315 ENOG4105KVH Transcriptional regulator WR52_30320 ENOG4108UW5 maltose o-acetyltransferase WR52_30350 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) WR52_30370 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) WR52_30390 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) WR52_30420 ENOG4105DY8 decarboxylase WR52_30425 ENOG4105CEY Amp-dependent synthetase and ligase WR52_30430 ENOG4108IUW ABC transporter WR52_30520 ENOG4105DR5 peptidase WR52_30555 ENOG4105K63 Thioredoxin