locus-tag	class	description
WR52_00010	COG0592	DNA-directed DNA polymerase activity
WR52_00015	COG2501	S4 domain
WR52_00025	COG0187	DNA topoisomerase II activity
WR52_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
WR52_00075	COG0470	DNA polymerase III
WR52_00080	COG1774	PSP1 C-terminal conserved region
WR52_00090	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
WR52_00100	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
WR52_00105	COG2002	toxin-antitoxin pair type II binding
WR52_00115	COG0084	hydrolase, TatD family'
WR52_00135	COG4466	Protein conserved in bacteria
WR52_00150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WR52_00155	COG0251	oxidation-reduction process
WR52_00170	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WR52_00185	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WR52_00190	COG2002	toxin-antitoxin pair type II binding
WR52_00195	COG2244	polysaccharide biosynthetic process
WR52_00200	COG3956	TIGRFAM MazG family protein
WR52_00205	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
WR52_00225	COG1098	S1 RNA binding domain
WR52_00240	COG2208	phosphoserine phosphatase activity
WR52_00255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WR52_00270	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
WR52_00275	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
WR52_00280	COG0512	Glutamine amidotransferase of anthranilate synthase
WR52_00285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WR52_00290	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WR52_00295	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
WR52_00300	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
WR52_00305	COG1396	sequence-specific DNA binding
WR52_00310	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WR52_00400	COG3880	PFAM UvrB UvrC protein
WR52_00410	COG0542	response to heat
WR52_00415	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
WR52_00425	COG4956	integral membrane protein (PIN domain superfamily)
WR52_00445	COG1045	serine acetyltransferase
WR52_00460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WR52_00465	COG3688	RNA-binding protein containing a PIN domain
WR52_00475	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WR52_00480	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
WR52_00485	COG0250	Participates in transcription elongation, termination and antitermination
WR52_00510	COG2813	Specifically methylates the guanine in position
WR52_00525	COG1358	cellular component organization or biogenesis
WR52_00630	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WR52_00655	COG0201	protein transport
WR52_00665	COG0024	Methionine aminopeptidase
WR52_00675	COG0257	Belongs to the bacterial ribosomal protein bL36 family
WR52_00710	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
WR52_00735	COG0860	N-Acetylmuramoyl-L-alanine amidase
WR52_00740	COG0489	protein tyrosine kinase activity
WR52_00750	COG2194	sulfuric ester hydrolase activity
WR52_00755	COG0726	polysaccharide deacetylase
WR52_00835	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
WR52_00840	COG4856	YbbR-like protein
WR52_00880	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_00885	COG2011	ABC-type metal ion transport system permease component
WR52_00890	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WR52_00895	COG1464	Belongs to the NlpA lipoprotein family
WR52_00900	COG0604	alcohol dehydrogenase
WR52_00910	COG0277	FAD linked oxidase domain protein
WR52_00915	COG2271	Major facilitator Superfamily
WR52_00925	COG2814	Major facilitator Superfamily
WR52_00940	COG2207	Transcriptional regulator
WR52_00955	COG4166	transmembrane transport
WR52_00960	COG4166	transmembrane transport
WR52_00965	COG0656	L-ascorbic acid biosynthetic process
WR52_00985	COG4149	molybdate abc transporter
WR52_00990	COG0725	ABC transporter, periplasmic molybdate-binding protein
WR52_00995	COG1910	domain protein
WR52_01015	COG0697	spore germination
WR52_01030	COG0204	Acyl-transferase
WR52_01040	COG1609	Transcriptional regulator
WR52_01050	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WR52_01070	COG5298	Protein conserved in bacteria
WR52_01095	COG0488	(ABC) transporter
WR52_01105	COG0747	negative chemotaxis
WR52_01110	COG0601	transmembrane transport
WR52_01120	COG0444	Belongs to the ABC transporter superfamily
WR52_01125	COG4608	Belongs to the ABC transporter superfamily
WR52_01130	COG0561	phosphatase activity
WR52_01160	COG3185	4-Hydroxyphenylpyruvate dioxygenase
WR52_01165	COG0179	Fumarylacetoacetate (FAA) hydrolase
WR52_01175	COG0531	amino acid
WR52_01180	COG2814	Major facilitator Superfamily
WR52_01190	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WR52_01200	COG4294	response to UV
WR52_01205	COG0705	Rhomboid family
WR52_01215	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
WR52_01220	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WR52_01225	COG0864	Transcriptional regulator
WR52_01230	COG2337	Toxic component of a toxin-antitoxin (TA) module
WR52_01235	COG2183	response to ionizing radiation
WR52_01335	COG0802	atpase or kinase
WR52_01340	COG1214	PFAM Peptidase M22, glycoprotease
WR52_01345	COG0456	acetyltransferase
WR52_01355	COG0488	(ABC) transporter
WR52_01370	COG1266	CAAX protease self-immunity
WR52_01390	COG2252	PERMEase
WR52_01400	COG5002	protein histidine kinase activity
WR52_01425	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
WR52_01475	COG1215	transferase activity, transferring glycosyl groups
WR52_01510	COG2205	protein histidine kinase activity
WR52_01515	COG0745	RESPONSE REGULATOR receiver
WR52_01535	COG0697	spore germination
WR52_01565	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WR52_01570	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WR52_01575	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WR52_01585	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WR52_01600	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
WR52_01610	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WR52_01620	COG0151	Belongs to the GarS family
WR52_01650	COG0210	DNA helicase
WR52_01660	COG4851	CamS sex pheromone cAM373 precursor
WR52_01675	COG1335	isochorismatase
WR52_01685	COG2011	ABC-type metal ion transport system permease component
WR52_01705	COG0003	Pfam Anion-transporting ATPase
WR52_01710	COG1846	Transcriptional regulator
WR52_01715	COG4682	membrane
WR52_01735	COG1597	lipid kinase activity
WR52_01745	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
WR52_01755	COG1012	belongs to the aldehyde dehydrogenase family
WR52_01760	COG2076	Multidrug Resistance protein
WR52_01770	COG2309	aminopeptidase activity
WR52_01785	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WR52_01795	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WR52_01800	COG4807	Protein conserved in bacteria
WR52_01830	COG1473	amidohydrolase
WR52_01850	COG0450	alkyl hydroperoxide reductase
WR52_01855	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
WR52_01865	COG0235	Class ii aldolase
WR52_01870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WR52_01875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WR52_01880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WR52_01905	COG0166	Belongs to the GPI family
WR52_01930	COG5002	protein histidine kinase activity
WR52_01950	COG3541	Predicted nucleotidyltransferase
WR52_01965	COG2814	Major facilitator Superfamily
WR52_01970	COG0723	plastoquinol--plastocyanin reductase activity
WR52_01970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WR52_01980	COG0765	amino acid transport
WR52_01985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WR52_01995	COG0840	transmembrane signaling receptor activity
WR52_02020	COG0549	Belongs to the carbamate kinase family
WR52_02025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WR52_02035	COG0277	FAD linked oxidase domain protein
WR52_02040	COG0366	Alpha amylase catalytic
WR52_02045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WR52_02045	COG1263	PTS System
WR52_02045	COG2190	(PTS) system
WR52_02075	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
WR52_02095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WR52_02100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
WR52_02105	COG1116	anion transmembrane transporter activity
WR52_02150	COG2270	Major facilitator Superfamily
WR52_02180	COG2310	stress, protein
WR52_02185	COG2310	stress, protein
WR52_02190	COG2310	stress, protein
WR52_02195	COG0861	Integral membrane protein TerC family
WR52_02205	COG3853	Toxic anion resistance protein (TelA)
WR52_02220	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
WR52_02230	COG1295	ribonuclease BN
WR52_02235	COG2217	Heavy metal translocating P-type atpase
WR52_02240	COG0697	spore germination
WR52_02260	COG0586	Pfam SNARE associated Golgi protein
WR52_02275	COG3871	stress protein (general stress protein 26)
WR52_02280	COG0387	Pfam Sodium calcium exchanger
WR52_02290	COG0535	radical SAM domain protein
WR52_02310	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
WR52_02315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WR52_02330	COG3829	transcription factor binding
WR52_02340	COG0833	amino acid
WR52_02345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WR52_02380	COG1263	PTS System
WR52_02380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WR52_02385	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WR52_02400	COG1216	Glycosyl transferase, family 2
WR52_02410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WR52_02410	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WR52_02415	COG0463	Glycosyl transferase, family 2
WR52_02430	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
WR52_02450	COG1228	amidohydrolase
WR52_02455	COG1090	epimerase
WR52_02485	COG1988	membrane-bound metal-dependent
WR52_02490	COG1194	a g-specific adenine glycosylase
WR52_02515	COG1132	(ABC) transporter
WR52_02520	COG4129	membrane
WR52_02525	COG0070	glutamate synthase
WR52_02525	COG0069	glutamate synthase activity
WR52_02525	COG0067	glutamate synthase
WR52_02535	COG4555	ABC transporter
WR52_02555	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WR52_02560	COG0735	belongs to the Fur family
WR52_02680	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
WR52_02705	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
WR52_02720	COG2766	serine protein kinase
WR52_02740	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
WR52_02750	COG1585	Membrane protein implicated in regulation of membrane protease activity
WR52_02755	COG2268	Band 7 protein
WR52_02765	COG3290	protein histidine kinase activity
WR52_02770	COG4565	transcriptional regulatory protein
WR52_02775	COG2851	Citrate transporter
WR52_02800	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
WR52_02805	COG3842	ATPase activity
WR52_02810	COG1175	transmembrane transport
WR52_02815	COG0395	ABC-type sugar transport system, permease component
WR52_02825	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WR52_02830	COG0745	RESPONSE REGULATOR receiver
WR52_02835	COG5002	protein histidine kinase activity
WR52_02845	COG4990	cell redox homeostasis
WR52_02855	COG3290	protein histidine kinase activity
WR52_02860	COG4565	transcriptional regulatory protein
WR52_02865	COG3493	citrate carrier protein
WR52_02870	COG0281	malic enzyme
WR52_02880	COG0697	spore germination
WR52_02885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WR52_02895	COG5002	protein histidine kinase activity
WR52_02915	COG0454	-acetyltransferase
WR52_02915	COG0456	acetyltransferase
WR52_02920	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
WR52_02925	COG3383	formate dehydrogenase (NAD+) activity
WR52_02930	COG2427	Protein of unknown function (DUF1641)
WR52_02945	COG0531	amino acid
WR52_02950	COG0640	Transcriptional regulator
WR52_02955	COG2217	Heavy metal translocating P-type atpase
WR52_02965	COG2801	Transposase and inactivated derivatives
WR52_02970	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
WR52_02980	COG3227	Zinc metalloprotease (Elastase)
WR52_03000	COG2720	vancomycin resistance protein
WR52_03005	COG1316	TRANSCRIPTIONal
WR52_03010	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WR52_03015	COG0346	lactoylglutathione lyase activity
WR52_03020	COG1253	flavin adenine dinucleotide binding
WR52_03025	COG1027	Aspartate ammonia-lyase
WR52_03030	COG1620	l-lactate permease
WR52_03045	COG3104	oligopeptide transport
WR52_03050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WR52_03055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WR52_03060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WR52_03070	COG2226	methyltransferase
WR52_03075	COG0156	8-amino-7-oxononanoate synthase activity
WR52_03080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WR52_03090	COG4548	von Willebrand factor, type A
WR52_03095	COG0714	Associated with various cellular activities
WR52_03115	COG0531	amino acid
WR52_03120	COG2188	Transcriptional regulator
WR52_03125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WR52_03125	COG1263	PTS System
WR52_03130	COG0366	Alpha amylase catalytic
WR52_03145	COG0697	spore germination
WR52_03150	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
WR52_03155	COG1115	amino acid carrier protein
WR52_03165	COG1126	abc transporter atp-binding protein
WR52_03170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WR52_03175	COG0765	amino acid transport
WR52_03180	COG0765	amino acid transport
WR52_03185	COG0833	amino acid
WR52_03200	COG2378	regulation of single-species biofilm formation
WR52_03205	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
WR52_03210	COG5002	protein histidine kinase activity
WR52_03235	COG0659	secondary active sulfate transmembrane transporter activity
WR52_03250	COG2271	Major facilitator Superfamily
WR52_03255	COG1846	Transcriptional regulator
WR52_03260	COG0477	Major facilitator Superfamily
WR52_03265	COG1609	Transcriptional regulator
WR52_03270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WR52_03285	COG1172	Belongs to the binding-protein-dependent transport system permease family
WR52_03290	COG1879	ABC-type sugar transport system periplasmic component
WR52_03295	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WR52_03310	COG1063	alcohol dehydrogenase
WR52_03360	COG0840	transmembrane signaling receptor activity
WR52_03365	COG1388	LysM domain
WR52_03365	COG3584	3D domain protein
WR52_03370	COG1476	TRANSCRIPTIONal
WR52_03390	COG3104	oligopeptide transport
WR52_03395	COG1114	Component of the transport system for branched-chain amino acids
WR52_03410	COG1113	amino acid transport
WR52_03415	COG2252	PERMEase
WR52_03440	COG2153	protein acetylation
WR52_03450	COG0569	domain protein
WR52_03450	COG0475	glutathione-regulated potassium exporter activity
WR52_03465	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WR52_03475	COG0833	amino acid
WR52_03480	COG4990	cell redox homeostasis
WR52_03495	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WR52_03500	COG0697	spore germination
WR52_03505	COG0531	amino acid
WR52_03520	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
WR52_03525	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
WR52_03530	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
WR52_03530	COG1918	ferrous iron import across plasma membrane
WR52_03535	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
WR52_03540	COG0573	inorganic phosphate transmembrane transporter activity
WR52_03545	COG0581	inorganic phosphate transmembrane transporter activity
WR52_03555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WR52_03675	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
WR52_03710	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
WR52_03715	COG1116	anion transmembrane transporter activity
WR52_03720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WR52_03725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
WR52_03730	COG0352	thiamine-phosphate diphosphorylase activity
WR52_03735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WR52_03740	COG2104	thiamine diphosphate biosynthetic process
WR52_03750	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WR52_03755	COG0351	phosphomethylpyrimidine kinase
WR52_03795	COG2205	protein histidine kinase activity
WR52_03800	COG2814	Major facilitator Superfamily
WR52_03805	COG1846	Transcriptional regulator
WR52_03820	COG2252	PERMEase
WR52_03825	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_03840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WR52_03845	COG1621	beta-fructofuranosidase activity
WR52_03850	COG1263	PTS System
WR52_03850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WR52_03855	COG1609	Transcriptional regulator
WR52_03905	COG0778	Nitroreductase
WR52_03910	COG2719	SpoVR family
WR52_03920	COG1414	Transcriptional regulator
WR52_03935	COG0446	pyridine nucleotide-disulphide oxidoreductase
WR52_03940	COG1937	Protein conserved in bacteria
WR52_03945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WR52_03945	COG0425	Belongs to the sulfur carrier protein TusA family
WR52_03950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WR52_03950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WR52_03955	COG0425	Belongs to the sulfur carrier protein TusA family
WR52_03965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WR52_03970	COG2210	Belongs to the sulfur carrier protein TusA family
WR52_03975	COG0730	response to heat
WR52_03985	COG1316	TRANSCRIPTIONal
WR52_03990	COG0604	alcohol dehydrogenase
WR52_03995	COG1283	sodium-dependent phosphate transmembrane transporter activity
WR52_04010	COG3711	transcriptional antiterminator
WR52_04010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
WR52_04015	COG1447	Phosphotransferase system cellobiose-specific component IIA
WR52_04020	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WR52_04040	COG1388	LysM domain
WR52_04040	COG3584	3D domain protein
WR52_04045	COG0577	efflux transmembrane transporter activity
WR52_04050	COG1136	(ABC) transporter
WR52_04060	COG5522	Integral membrane protein (intg_mem_TP0381)
WR52_04075	COG1114	Component of the transport system for branched-chain amino acids
WR52_04080	COG3546	catalase activity
WR52_04115	COG0586	Pfam SNARE associated Golgi protein
WR52_04150	COG0531	amino acid
WR52_04155	COG0475	glutathione-regulated potassium exporter activity
WR52_04165	COG1737	Transcriptional regulator
WR52_04175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WR52_04175	COG1263	PTS System
WR52_04185	COG2259	Doxx family
WR52_04205	COG1522	sequence-specific DNA binding
WR52_04210	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
WR52_04210	COG0165	Argininosuccinate lyase
WR52_04215	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_04225	COG2076	Multidrug Resistance protein
WR52_04230	COG2076	Multidrug Resistance protein
WR52_04235	COG1309	transcriptional regulator
WR52_04240	COG2814	Major facilitator Superfamily
WR52_04245	COG1733	regulation of RNA biosynthetic process
WR52_04255	COG2249	NAD(P)H dehydrogenase (quinone) activity
WR52_04260	COG4533	DNA binding
WR52_04265	COG2211	Major facilitator Superfamily
WR52_04275	COG0693	protein deglycase activity
WR52_04280	COG0693	protein deglycase activity
WR52_04280	COG0753	catalase activity
WR52_04290	COG0531	amino acid
WR52_04305	COG1012	belongs to the aldehyde dehydrogenase family
WR52_04315	COG1132	(ABC) transporter
WR52_04320	COG1132	(ABC) transporter
WR52_04325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WR52_04330	COG0765	amino acid transport
WR52_04335	COG1126	abc transporter atp-binding protein
WR52_04350	COG0189	ligase activity
WR52_04370	COG4585	Histidine kinase
WR52_04375	COG2197	response regulator
WR52_04380	COG0028	Belongs to the TPP enzyme family
WR52_04385	COG3527	Alpha-acetolactate decarboxylase
WR52_04395	COG0561	phosphatase activity
WR52_04405	COG3409	Peptidoglycan-binding domain 1 protein
WR52_04405	COG5632	N-Acetylmuramoyl-L-alanine amidase
WR52_04410	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WR52_04415	COG0318	PFAM AMP-dependent synthetase and ligase
WR52_04430	COG0659	secondary active sulfate transmembrane transporter activity
WR52_04435	COG2244	polysaccharide biosynthetic process
WR52_04455	COG1024	Enoyl-CoA hydratase
WR52_04475	COG1363	Peptidase, m42
WR52_04490	COG2801	Transposase and inactivated derivatives
WR52_04520	COG0601	transmembrane transport
WR52_04525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WR52_04530	COG0444	Belongs to the ABC transporter superfamily
WR52_04535	COG4608	Belongs to the ABC transporter superfamily
WR52_04545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WR52_04675	COG0477	Major facilitator Superfamily
WR52_04680	COG3290	protein histidine kinase activity
WR52_04685	COG4565	transcriptional regulatory protein
WR52_04690	COG3181	Tripartite tricarboxylate transporter family receptor
WR52_04705	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
WR52_04745	COG0305	Participates in initiation and elongation during chromosome replication
WR52_04770	COG0477	Major facilitator Superfamily
WR52_04785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WR52_04810	COG1073	alpha beta
WR52_04865	COG1183	phosphatidylcholine synthase activity
WR52_04880	COG2376	Dihydroxyacetone kinase
WR52_04890	COG2376	Dihydroxyacetone kinase
WR52_04925	COG1388	LysM domain
WR52_04925	COG3584	3D domain protein
WR52_04930	COG0791	NLP P60 protein
WR52_04930	COG1388	LysM domain
WR52_04935	COG2373	Large extracellular alpha-helical protein
WR52_04955	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
WR52_05025	COG3237	CsbD-like
WR52_05050	COG1191	sigma factor activity
WR52_05060	COG2208	phosphoserine phosphatase activity
WR52_05065	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
WR52_05070	COG2205	protein histidine kinase activity
WR52_05070	COG0784	Response regulator, receiver
WR52_05070	COG5002	protein histidine kinase activity
WR52_05095	COG0393	Putative heavy-metal-binding
WR52_05110	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
WR52_05130	COG0420	3'-5' exonuclease activity
WR52_05135	COG4717	serine-type aminopeptidase activity
WR52_05155	COG1280	lysine exporter protein (LysE YggA)
WR52_05160	COG0346	lactoylglutathione lyase activity
WR52_05165	COG0346	lactoylglutathione lyase activity
WR52_05170	COG0457	Tetratricopeptide repeat
WR52_05180	COG2267	carboxylic ester hydrolase activity
WR52_05200	COG2140	Oxalate decarboxylase
WR52_05210	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
WR52_05215	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WR52_05225	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
WR52_05285	COG1136	(ABC) transporter
WR52_05300	COG1595	DNA-templated transcription, initiation
WR52_05310	COG0772	Belongs to the SEDS family
WR52_05320	COG3973	AAA domain
WR52_05355	COG4980	gas vesicle protein
WR52_05360	COG0537	adenosine 5'-monophosphoramidase activity
WR52_05365	COG1131	(ABC) transporter
WR52_05370	COG4473	ABC transporter
WR52_05380	COG1309	transcriptional regulator
WR52_05390	COG3402	PFAM membrane-flanked domain
WR52_05395	COG3428	Bacterial PH domain
WR52_05430	COG0697	spore germination
WR52_05435	COG3402	PFAM membrane-flanked domain
WR52_05440	COG3428	Bacterial PH domain
WR52_05445	COG2329	Antibiotic biosynthesis monooxygenase
WR52_05450	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WR52_05490	COG1309	transcriptional regulator
WR52_05495	COG1511	domain protein
WR52_05520	COG2378	regulation of single-species biofilm formation
WR52_05525	COG1609	Transcriptional regulator
WR52_05535	COG1234	tRNA 3'-trailer cleavage
WR52_05540	COG0095	Lipoate-protein ligase
WR52_05550	COG0318	PFAM AMP-dependent synthetase and ligase
WR52_05600	COG1408	metallophosphoesterase
WR52_05605	COG1078	dGTPase activity
WR52_05610	COG1595	DNA-templated transcription, initiation
WR52_05615	COG3708	Transcriptional regulator
WR52_05615	COG2207	Transcriptional regulator
WR52_05625	COG2205	protein histidine kinase activity
WR52_05630	COG0745	RESPONSE REGULATOR receiver
WR52_05650	COG0501	Belongs to the peptidase M48B family
WR52_05655	COG0840	transmembrane signaling receptor activity
WR52_05660	COG3693	PFAM glycoside hydrolase, family 10
WR52_05670	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
WR52_05675	COG2224	Isocitrate lyase
WR52_05695	COG1278	Cold shock
WR52_05715	COG0398	Pfam SNARE associated Golgi protein
WR52_05775	COG0179	Fumarylacetoacetate (FAA) hydrolase
WR52_05800	COG0367	asparagine synthase
WR52_05810	COG0753	catalase activity
WR52_05815	COG0004	ammonium transporteR
WR52_05835	COG2996	Protein conserved in bacteria
WR52_05850	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WR52_05865	COG0561	phosphatase activity
WR52_05890	COG2267	carboxylic ester hydrolase activity
WR52_05910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WR52_05915	COG5504	Zn-dependent protease
WR52_05925	COG0180	Tryptophanyl-tRNA synthetase
WR52_05935	COG4166	transmembrane transport
WR52_05940	COG0601	transmembrane transport
WR52_05945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WR52_05950	COG0444	Belongs to the ABC transporter superfamily
WR52_05955	COG4608	Belongs to the ABC transporter superfamily
WR52_05960	COG0534	Mate efflux family protein
WR52_05965	COG4166	transmembrane transport
WR52_05980	COG1393	Belongs to the ArsC family
WR52_05985	COG0861	Integral membrane protein TerC family
WR52_06005	COG2801	Transposase and inactivated derivatives
WR52_06015	COG1164	Oligoendopeptidase f
WR52_06030	COG2346	COG2346, Truncated hemoglobins
WR52_06035	COG4116	CYTH
WR52_06045	COG2357	RelA SpoT domain protein
WR52_06055	COG0564	pseudouridine synthase activity
WR52_06070	COG0772	Belongs to the SEDS family
WR52_06075	COG1216	Glycosyl transferase, family 2
WR52_06095	COG0457	Tetratricopeptide repeat
WR52_06095	COG0463	Glycosyl transferase, family 2
WR52_06115	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
WR52_06130	COG1091	dTDP-4-dehydrorhamnose reductase activity
WR52_06175	COG2153	protein acetylation
WR52_06185	COG2382	esterase
WR52_06205	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WR52_06220	COG0512	Glutamine amidotransferase of anthranilate synthase
WR52_06220	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WR52_06255	COG1620	l-lactate permease
WR52_06260	COG5634	Uncharacterized conserved protein (DUF2278)
WR52_06310	COG0508	dehydrogenase complex catalyzes the overall conversion of
WR52_06320	COG1476	TRANSCRIPTIONal
WR52_06380	COG1686	Belongs to the peptidase S11 family
WR52_06385	COG0681	Belongs to the peptidase S26 family
WR52_06420	COG1012	belongs to the aldehyde dehydrogenase family
WR52_06430	COG1176	ABC-type spermidine putrescine transport system, permease component I
WR52_06435	COG1177	transmembrane transport
WR52_06440	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
WR52_06450	COG2409	Drug exporters of the RND superfamily
WR52_06460	COG0564	pseudouridine synthase activity
WR52_06470	COG2340	Cysteine-rich secretory protein family
WR52_06475	COG0247	lactate metabolic process
WR52_06480	COG0277	FAD linked oxidase domain protein
WR52_06485	COG3835	regulator
WR52_06495	COG0745	RESPONSE REGULATOR receiver
WR52_06500	COG5002	protein histidine kinase activity
WR52_06505	COG2186	Transcriptional regulator
WR52_06525	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
WR52_06535	COG2116	formate transmembrane transporter activity
WR52_06540	COG0861	Integral membrane protein TerC family
WR52_06545	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WR52_06555	COG2030	dehydratase
WR52_06575	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_06580	COG3243	poly(R)-hydroxyalkanoic acid synthase
WR52_06590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WR52_06605	COG1840	ABC-type Fe3 transport system, periplasmic component
WR52_06610	COG3842	ATPase activity
WR52_06635	COG1349	DNA-binding transcription factor activity
WR52_06650	COG0235	Class ii aldolase
WR52_06660	COG2861	carbohydrate metabolic process
WR52_06675	COG3852	Histidine kinase
WR52_06680	COG1846	Transcriptional regulator
WR52_06690	COG2318	DinB family
WR52_06700	COG5002	protein histidine kinase activity
WR52_06710	COG0720	synthase
WR52_06725	COG4873	Protein conserved in bacteria
WR52_06765	COG1780	Probably involved in ribonucleotide reductase function
WR52_06770	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WR52_06775	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WR52_06780	COG1725	Transcriptional regulator
WR52_06785	COG1131	(ABC) transporter
WR52_06795	COG1131	(ABC) transporter
WR52_06800	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
WR52_06815	COG1522	sequence-specific DNA binding
WR52_06825	COG1335	isochorismatase
WR52_06835	COG1619	proteins homologs of microcin C7 resistance protein MccF
WR52_06840	COG2070	2-Nitropropane dioxygenase
WR52_06845	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
WR52_06855	COG1696	Membrane protein involved in D-alanine export
WR52_06880	COG0716	FMN binding
WR52_06940	COG1846	Transcriptional regulator
WR52_06950	COG1301	dicarboxylic acid transport
WR52_06955	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WR52_06960	COG4709	membrane
WR52_06965	COG3874	Sporulation protein YtfJ
WR52_06995	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WR52_07000	COG0028	Belongs to the TPP enzyme family
WR52_07005	COG0440	acetolactate synthase activity
WR52_07080	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
WR52_07095	COG1183	phosphatidylcholine synthase activity
WR52_07100	COG1368	sulfuric ester hydrolase activity
WR52_07110	COG0019	diaminopimelate decarboxylase activity
WR52_07130	COG0529	Catalyzes the synthesis of activated sulfate
WR52_07135	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WR52_07155	COG1648	precorrin-2 dehydrogenase activity
WR52_07165	COG0733	neurotransmitter:sodium symporter activity
WR52_07185	COG1757	Na H antiporter
WR52_07200	COG4758	membrane
WR52_07205	COG4585	Histidine kinase
WR52_07210	COG2197	response regulator
WR52_07220	COG1114	Component of the transport system for branched-chain amino acids
WR52_07230	COG2226	methyltransferase
WR52_07275	COG0730	response to heat
WR52_07280	COG0306	phosphate transporter
WR52_07285	COG1392	Phosphate transport regulator
WR52_07290	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WR52_07305	COG3852	Histidine kinase
WR52_07310	COG1801	Protein of unknown function DUF72
WR52_07320	COG0582	viral genome integration into host DNA
WR52_07325	COG5002	protein histidine kinase activity
WR52_07340	COG0392	lysyltransferase activity
WR52_07340	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
WR52_07355	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WR52_07360	COG1686	Belongs to the peptidase S11 family
WR52_07365	COG2715	membrane protein required for spore maturation
WR52_07370	COG0700	Nucleoside recognition
WR52_07375	COG1187	pseudouridine synthase activity
WR52_07385	COG1333	cytochrome c biogenesis protein
WR52_07390	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WR52_07395	COG0745	RESPONSE REGULATOR receiver
WR52_07400	COG5002	protein histidine kinase activity
WR52_07405	COG2096	Adenosyltransferase
WR52_07420	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
WR52_07425	COG1141	Ferredoxin
WR52_07435	COG0514	ATP-dependent DNA helicase (RecQ)
WR52_07440	COG1266	CAAX protease self-immunity
WR52_07450	COG1408	metallophosphoesterase
WR52_07455	COG0789	Transcriptional regulator
WR52_07465	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
WR52_07485	COG0492	ferredoxin-NADP+ reductase activity
WR52_07490	COG0252	asparaginase activity
WR52_07560	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
WR52_07575	COG0142	geranyltranstransferase activity
WR52_07585	COG0142	geranyltranstransferase activity
WR52_07610	COG0457	Tetratricopeptide repeat
WR52_07630	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WR52_07635	COG2010	Cytochrome c
WR52_07635	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WR52_07640	COG4347	Protein of unknown function (DUF1405)
WR52_07655	COG2738	Putative neutral zinc metallopeptidase
WR52_07665	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WR52_07670	COG1694	Mazg nucleotide pyrophosphohydrolase
WR52_07690	COG0438	transferase activity, transferring glycosyl groups
WR52_07725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WR52_07725	COG1199	ATP-dependent helicase activity
WR52_07745	COG3935	DnaD domain protein
WR52_07750	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
WR52_07760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WR52_07760	COG4499	WXG100 protein secretion system (Wss), protein YukC
WR52_07810	COG0116	Belongs to the methyltransferase superfamily
WR52_07820	COG1199	ATP-dependent helicase activity
WR52_07825	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
WR52_07835	COG0024	Methionine aminopeptidase
WR52_07845	COG2233	PERMEase
WR52_07850	COG2311	Membrane
WR52_07855	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
WR52_07865	COG0456	acetyltransferase
WR52_07905	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WR52_07920	COG3944	biosynthesis protein
WR52_07930	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WR52_07945	COG1215	transferase activity, transferring glycosyl groups
WR52_07950	COG0438	transferase activity, transferring glycosyl groups
WR52_07965	COG0454	-acetyltransferase
WR52_07985	COG0328	RNA-DNA hybrid ribonuclease activity
WR52_08020	COG3403	YqcI/YcgG family
WR52_08025	COG1280	lysine exporter protein (LysE YggA)
WR52_08045	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WR52_08050	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
WR52_08060	COG0475	glutathione-regulated potassium exporter activity
WR52_08065	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
WR52_08070	COG4978	Transcriptional regulator
WR52_08070	COG0789	Transcriptional regulator
WR52_08080	COG2323	membrane
WR52_08085	COG1434	Gram-negative-bacterium-type cell wall biogenesis
WR52_08120	COG1923	regulation of RNA biosynthetic process
WR52_08130	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WR52_08135	COG1360	Flagellar Motor Protein
WR52_08140	COG2201	protein-glutamate methylesterase activity
WR52_08145	COG2198	Histidine kinase
WR52_08145	COG0643	Histidine kinase
WR52_08150	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WR52_08150	COG1776	CheC inhibitor of MCP methylation
WR52_08165	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
WR52_08185	COG1256	bacterial-type flagellum assembly
WR52_08190	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WR52_08195	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
WR52_08210	COG1815	bacterial-type flagellum-dependent cell motility
WR52_08215	COG1558	bacterial-type flagellum-dependent cell motility
WR52_08220	COG1677	Flagellar hook-basal body complex protein FliE
WR52_08225	COG1766	The M ring may be actively involved in energy transduction
WR52_08230	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WR52_08240	COG1157	protein secretion by the type III secretion system
WR52_08275	COG0784	Response regulator, receiver
WR52_08275	COG0835	chemotaxis
WR52_08285	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WR52_08290	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WR52_08295	COG0741	lytic transglycosylase activity
WR52_08305	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WR52_08310	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WR52_08310	COG1776	CheC inhibitor of MCP methylation
WR52_08320	COG1338	Plays a role in the flagellum-specific transport system
WR52_08325	COG1987	bacterial-type flagellum assembly
WR52_08335	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
WR52_08340	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
WR52_08345	COG1419	protein localization to endoplasmic reticulum
WR52_08350	COG4786	Flagellar basal body rod
WR52_08355	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WR52_08390	COG2329	Antibiotic biosynthesis monooxygenase
WR52_08430	COG1177	transmembrane transport
WR52_08435	COG1234	tRNA 3'-trailer cleavage
WR52_08460	COG0406	alpha-ribazole phosphatase activity
WR52_08490	COG0367	asparagine synthase
WR52_08520	COG1802	Transcriptional regulator
WR52_08525	COG0697	spore germination
WR52_08535	COG0523	cobalamin synthesis protein
WR52_08540	COG0701	Predicted permease
WR52_08555	COG1757	Na H antiporter
WR52_08560	COG0789	Transcriptional regulator
WR52_08595	COG0534	Mate efflux family protein
WR52_08600	COG3340	Belongs to the peptidase S51 family
WR52_08620	COG0785	Cytochrome C biogenesis protein
WR52_08635	COG0457	Tetratricopeptide repeat
WR52_08655	COG2733	membrane
WR52_08690	COG1131	(ABC) transporter
WR52_08705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WR52_08710	COG0528	UMP kinase activity
WR52_08720	COG1027	Aspartate ammonia-lyase
WR52_08725	COG0281	malic enzyme
WR52_08730	COG4191	Histidine kinase
WR52_08735	COG0784	Response regulator, receiver
WR52_08740	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WR52_08795	COG2814	Major facilitator Superfamily
WR52_08810	COG1695	Transcriptional regulator
WR52_08825	COG0477	Major facilitator Superfamily
WR52_08835	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WR52_08840	COG2223	nitrite transmembrane transporter activity
WR52_08845	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
WR52_08865	COG0733	neurotransmitter:sodium symporter activity
WR52_08875	COG5566	PFAM Mor transcription activator
WR52_08880	COG2323	membrane
WR52_08900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WR52_08910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WR52_08915	COG0028	Belongs to the TPP enzyme family
WR52_08935	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
WR52_08960	COG2814	Major facilitator Superfamily
WR52_08965	COG3384	dioxygenase
WR52_08975	COG3279	Response regulator of the LytR AlgR family
WR52_08980	COG0427	acetyl-CoA hydrolase
WR52_09000	COG4166	transmembrane transport
WR52_09005	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WR52_09010	COG1914	H( )-stimulated, divalent metal cation uptake system
WR52_09025	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
WR52_09035	COG0531	amino acid
WR52_09065	COG2309	aminopeptidase activity
WR52_09080	COG0456	acetyltransferase
WR52_09090	COG1266	CAAX protease self-immunity
WR52_09095	COG1309	transcriptional regulator
WR52_09100	COG2390	Transcriptional regulator
WR52_09110	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WR52_09115	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
WR52_09125	COG4846	Membrane protein involved in cytochrome C biogenesis
WR52_09150	COG0006	proline dipeptidase activity
WR52_09160	COG2132	Multicopper oxidase
WR52_09185	COG0798	PFAM Bile acid sodium symporter
WR52_09195	COG1114	Component of the transport system for branched-chain amino acids
WR52_09205	COG1276	copper resistance
WR52_09205	COG2372	response to copper ion
WR52_09210	COG4549	nuclear export factor GLE1
WR52_09215	COG0697	spore germination
WR52_09220	COG0583	DNA-binding transcription factor activity
WR52_09225	COG1959	2 iron, 2 sulfur cluster binding
WR52_09230	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
WR52_09235	COG0778	Nitroreductase
WR52_09250	COG0628	permease
WR52_09260	COG1231	oxidoreductase activity
WR52_09265	COG0523	cobalamin synthesis protein
WR52_09275	COG0411	ABC transporter
WR52_09285	COG0559	Belongs to the binding-protein-dependent transport system permease family
WR52_09295	COG0583	DNA-binding transcription factor activity
WR52_09325	COG1271	oxidase subunit
WR52_09330	COG1294	oxidase, subunit
WR52_09335	COG4988	ABC transporter
WR52_09340	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
WR52_09350	COG1216	Glycosyl transferase, family 2
WR52_09390	COG1686	Belongs to the peptidase S11 family
WR52_09405	COG1388	LysM domain
WR52_09405	COG0791	NLP P60 protein
WR52_09415	COG1132	(ABC) transporter
WR52_09420	COG0745	RESPONSE REGULATOR receiver
WR52_09425	COG5002	protein histidine kinase activity
WR52_09435	COG0300	oxidoreductase activity
WR52_09445	COG0726	polysaccharide deacetylase
WR52_09465	COG0460	homoserine dehydrogenase
WR52_09490	COG1316	TRANSCRIPTIONal
WR52_09500	COG0745	RESPONSE REGULATOR receiver
WR52_09505	COG5002	protein histidine kinase activity
WR52_09510	COG0726	polysaccharide deacetylase
WR52_09520	COG1285	pathogenesis
WR52_09525	COG1247	-acetyltransferase
WR52_09535	COG4264	IucA IucC family
WR52_09540	COG0318	PFAM AMP-dependent synthetase and ligase
WR52_09555	COG1082	Xylose isomerase domain protein TIM barrel
WR52_09565	COG2814	Major facilitator Superfamily
WR52_09570	COG1279	arginine transmembrane transporter activity
WR52_09575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WR52_09585	COG1752	Esterase of the alpha-beta hydrolase superfamily
WR52_09620	COG2801	Transposase and inactivated derivatives
WR52_09630	COG0577	efflux transmembrane transporter activity
WR52_09635	COG2002	toxin-antitoxin pair type II binding
WR52_09640	COG1404	Belongs to the peptidase S8 family
WR52_09645	COG0640	Transcriptional regulator
WR52_09650	COG0667	Aldo Keto reductase
WR52_09655	COG2814	Major facilitator Superfamily
WR52_09665	COG3152	Membrane
WR52_09690	COG0840	transmembrane signaling receptor activity
WR52_09710	COG3949	Membrane
WR52_09715	COG0783	Belongs to the Dps family
WR52_09730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WR52_09740	COG1231	oxidoreductase activity
WR52_09745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WR52_09750	COG4989	oxidoreductase activity
WR52_09755	COG0523	cobalamin synthesis protein
WR52_09760	COG0456	acetyltransferase
WR52_09765	COG0803	Belongs to the bacterial solute-binding protein 9 family
WR52_09775	COG0702	epimerase
WR52_09785	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
WR52_09795	COG4166	transmembrane transport
WR52_09820	COG5337	Spore coat protein CotH
WR52_09825	COG1051	belongs to the nudix hydrolase family
WR52_09830	COG0586	Pfam SNARE associated Golgi protein
WR52_09835	COG2244	polysaccharide biosynthetic process
WR52_09845	COG0701	Predicted permease
WR52_09850	COG3689	TIGRFAM TIGR03943 family protein
WR52_09855	COG1607	acyl-coa hydrolase
WR52_09860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WR52_09875	COG0702	epimerase
WR52_09880	COG2839	Protein conserved in bacteria
WR52_09885	COG1253	flavin adenine dinucleotide binding
WR52_09900	COG1114	Component of the transport system for branched-chain amino acids
WR52_09905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WR52_09925	COG0860	N-Acetylmuramoyl-L-alanine amidase
WR52_09935	COG1876	peptidase activity
WR52_09945	COG2211	Major facilitator Superfamily
WR52_09960	COG0860	N-Acetylmuramoyl-L-alanine amidase
WR52_09970	COG0561	phosphatase activity
WR52_09985	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WR52_10000	COG1819	glycosyl
WR52_10005	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WR52_10010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WR52_10040	COG0456	acetyltransferase
WR52_10065	COG1511	domain protein
WR52_10065	COG0842	Transport permease protein
WR52_10080	COG4499	WXG100 protein secretion system (Wss), protein YukC
WR52_10145	COG3874	Sporulation protein YtfJ
WR52_10170	COG2226	methyltransferase
WR52_10190	COG1082	Xylose isomerase domain protein TIM barrel
WR52_10195	COG0346	lactoylglutathione lyase activity
WR52_10205	COG0604	alcohol dehydrogenase
WR52_10210	COG1595	DNA-templated transcription, initiation
WR52_10225	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
WR52_10225	COG0426	domain, Protein
WR52_10235	COG0386	Belongs to the glutathione peroxidase family
WR52_10240	COG1305	Transglutaminase-like
WR52_10245	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
WR52_10250	COG0714	Associated with various cellular activities
WR52_10255	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
WR52_10260	COG1140	nitrate reductase beta subunit
WR52_10265	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
WR52_10270	COG2181	nitrate reductase activity
WR52_10275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WR52_10280	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
WR52_10285	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WR52_10290	COG0303	'Molybdopterin
WR52_10295	COG0314	molybdopterin synthase activity
WR52_10305	COG2223	nitrite transmembrane transporter activity
WR52_10325	COG1648	precorrin-2 dehydrogenase activity
WR52_10335	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WR52_10335	COG1587	Uroporphyrinogen-III synthase
WR52_10340	COG2146	nitrite reductase [NAD(P)H] activity
WR52_10345	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WR52_10350	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
WR52_10370	COG2162	N-hydroxyarylamine O-acetyltransferase activity
WR52_10385	COG2359	stage V sporulation protein S
WR52_10410	COG0457	Tetratricopeptide repeat
WR52_10425	COG2856	Zn peptidase
WR52_10430	COG1396	sequence-specific DNA binding
WR52_10485	COG0662	Cupin 2, conserved barrel domain protein
WR52_10510	COG0582	viral genome integration into host DNA
WR52_10545	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WR52_10555	COG5484	DNA packaging
WR52_10560	COG1783	phage Terminase large subunit
WR52_10575	COG0338	D12 class N6 adenine-specific DNA methyltransferase
WR52_10700	COG0457	Tetratricopeptide repeat
WR52_10740	COG1418	mRNA catabolic process
WR52_10745	COG0488	(ABC) transporter
WR52_10760	COG0629	single-stranded DNA binding
WR52_10765	COG1413	lyase activity
WR52_10780	COG2521	methyltransferase
WR52_10780	COG2136	Putative SAM-dependent methyltransferase
WR52_10785	COG0018	arginyl-trna synthetase
WR52_10830	COG0017	Asparaginyl-tRNA synthetase
WR52_10835	COG1929	Belongs to the glycerate kinase type-1 family
WR52_10845	COG0745	RESPONSE REGULATOR receiver
WR52_10850	COG3850	Histidine kinase
WR52_10850	COG5002	protein histidine kinase activity
WR52_10865	COG0733	neurotransmitter:sodium symporter activity
WR52_10890	COG2610	gluconate transmembrane transporter activity
WR52_10900	COG1794	racemase activity, acting on amino acids and derivatives
WR52_10910	COG0456	acetyltransferase
WR52_10920	COG3655	Transcriptional regulator
WR52_10925	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
WR52_10940	COG4473	ABC transporter
WR52_10950	COG0546	phosphoglycolate phosphatase activity
WR52_10965	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WR52_10980	COG0768	penicillin binding
WR52_10990	COG0204	Acyl-transferase
WR52_10995	COG1272	protein, Hemolysin III
WR52_11005	COG0805	protein transport
WR52_11015	COG1307	EDD domain protein, DegV family
WR52_11025	COG1999	signal sequence binding
WR52_11030	COG0071	Belongs to the small heat shock protein (HSP20) family
WR52_11035	COG0367	asparagine synthase
WR52_11050	COG0860	N-Acetylmuramoyl-L-alanine amidase
WR52_11055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WR52_11060	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WR52_11145	COG2801	Transposase and inactivated derivatives
WR52_11150	COG0668	transmembrane transport
WR52_11155	COG2203	Gaf domain
WR52_11155	COG4585	Histidine kinase
WR52_11160	COG2197	response regulator
WR52_11165	COG1737	Transcriptional regulator
WR52_11170	COG0384	phenazine biosynthesis protein PhzF
WR52_11175	COG1064	alcohol dehydrogenase
WR52_11200	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
WR52_11235	COG0517	IMP dehydrogenase activity
WR52_11235	COG1125	glycine betaine transport
WR52_11240	COG1174	glycine betaine transport
WR52_11275	COG1253	flavin adenine dinucleotide binding
WR52_11280	COG1012	belongs to the aldehyde dehydrogenase family
WR52_11285	COG5506	Protein of unknown function (DUF1694)
WR52_11300	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
WR52_11305	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
WR52_11310	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
WR52_11315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WR52_11320	COG0456	acetyltransferase
WR52_11325	COG3829	transcription factor binding
WR52_11330	COG1509	lysine 2,3-aminomutase activity
WR52_11365	COG4991	sh3 domain protein
WR52_11365	COG3064	Membrane
WR52_11365	COG0515	serine threonine protein kinase
WR52_11375	COG0671	phosphoesterase, PA-phosphatase related
WR52_11380	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
WR52_11385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WR52_11505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WR52_11505	COG4499	WXG100 protein secretion system (Wss), protein YukC
WR52_11515	COG2814	Major facilitator Superfamily
WR52_11520	COG4841	protein insertion into membrane
WR52_11525	COG0372	Belongs to the citrate synthase family
WR52_11530	COG2079	MmgE PrpD family protein
WR52_11535	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
WR52_11540	COG1960	acyl-CoA dehydrogenase activity
WR52_11545	COG2084	Dehydrogenase
WR52_11555	COG1280	lysine exporter protein (LysE YggA)
WR52_11560	COG1024	Enoyl-CoA hydratase
WR52_11575	COG0420	3'-5' exonuclease activity
WR52_11580	COG0419	ATPase involved in DNA repair
WR52_11605	COG2223	nitrite transmembrane transporter activity
WR52_11610	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_11615	COG1169	isochorismate synthase
WR52_11620	COG1021	2,3-dihydroxybenzoate-AMP ligase
WR52_11625	COG1535	isochorismatase
WR52_11625	COG3433	isochorismatase activity
WR52_11630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WR52_11635	COG3251	PFAM MbtH domain protein
WR52_11640	COG2814	Major facilitator Superfamily
WR52_11655	COG0776	regulation of translation
WR52_11665	COG2318	DinB family
WR52_11675	COG1115	amino acid carrier protein
WR52_11695	COG1187	pseudouridine synthase activity
WR52_11700	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WR52_11705	COG1136	(ABC) transporter
WR52_11755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WR52_11770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WR52_11805	COG1247	-acetyltransferase
WR52_11840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WR52_11870	COG0583	DNA-binding transcription factor activity
WR52_11875	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WR52_11895	COG0583	DNA-binding transcription factor activity
WR52_11900	COG2258	MOSC domain
WR52_11915	COG1132	(ABC) transporter
WR52_11920	COG1132	(ABC) transporter
WR52_11950	COG1396	sequence-specific DNA binding
WR52_11990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WR52_11995	COG1595	DNA-templated transcription, initiation
WR52_12020	COG1649	PFAM Uncharacterised BCR, COG1649
WR52_12045	COG2971	BadF BadG BcrA BcrD
WR52_12055	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
WR52_12065	COG1846	Transcriptional regulator
WR52_12080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WR52_12105	COG1309	transcriptional regulator
WR52_12125	COG0500	methyltransferase
WR52_12125	COG3615	Tellurite resistance protein tehB
WR52_12145	COG1846	Transcriptional regulator
WR52_12175	COG2195	Cleaves the N-terminal amino acid of tripeptides
WR52_12185	COG2801	Transposase and inactivated derivatives
WR52_12210	COG2002	toxin-antitoxin pair type II binding
WR52_12220	COG0730	response to heat
WR52_12225	COG0110	maltose O-acetyltransferase activity
WR52_12230	COG1686	Belongs to the peptidase S11 family
WR52_12235	COG2814	Major facilitator Superfamily
WR52_12270	COG2312	Erythromycin esterase
WR52_12275	COG0741	lytic transglycosylase activity
WR52_12280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WR52_12295	COG0768	penicillin binding
WR52_12300	COG1595	DNA-templated transcription, initiation
WR52_12310	COG0768	penicillin binding
WR52_12325	COG1408	metallophosphoesterase
WR52_12335	COG1131	(ABC) transporter
WR52_12345	COG1309	transcriptional regulator
WR52_12360	COG1960	acyl-CoA dehydrogenase activity
WR52_12365	COG0439	Biotin carboxylase
WR52_12370	COG0511	ligase activity, forming carbon-carbon bonds
WR52_12375	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WR52_12380	COG1024	Enoyl-CoA hydratase
WR52_12385	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WR52_12390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WR52_12410	COG0572	uridine kinase
WR52_12425	COG1686	Belongs to the peptidase S11 family
WR52_12455	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
WR52_12475	COG3227	Zinc metalloprotease (Elastase)
WR52_12480	COG2207	Transcriptional regulator
WR52_12510	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WR52_12530	COG2226	methyltransferase
WR52_12535	COG0596	Alpha beta hydrolase
WR52_12545	COG1942	4-Oxalocrotonate Tautomerase
WR52_12550	COG0583	DNA-binding transcription factor activity
WR52_12570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WR52_12605	COG3386	PFAM SMP-30 Gluconolaconase
WR52_12615	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
WR52_12630	COG0745	RESPONSE REGULATOR receiver
WR52_12635	COG2205	protein histidine kinase activity
WR52_12650	COG1136	(ABC) transporter
WR52_12655	COG0577	efflux transmembrane transporter activity
WR52_12675	COG0460	homoserine dehydrogenase
WR52_12680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WR52_12690	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
WR52_12715	COG0582	viral genome integration into host DNA
WR52_12760	COG2002	toxin-antitoxin pair type II binding
WR52_12820	COG0582	viral genome integration into host DNA
WR52_12830	COG0531	amino acid
WR52_12835	COG2801	Transposase and inactivated derivatives
WR52_12945	COG4824	toxin secretion phage lysis holin
WR52_12990	COG2124	cytochrome p450
WR52_13025	COG0561	phosphatase activity
WR52_13030	COG5002	protein histidine kinase activity
WR52_13045	COG1819	glycosyl
WR52_13050	COG1794	racemase activity, acting on amino acids and derivatives
WR52_13070	COG2205	protein histidine kinase activity
WR52_13080	COG2801	Transposase and inactivated derivatives
WR52_13130	COG0604	alcohol dehydrogenase
WR52_13135	COG0671	phosphoesterase, PA-phosphatase related
WR52_13180	COG0693	protein deglycase activity
WR52_13195	COG0584	glycerophosphoryl diester phosphodiesterase
WR52_13215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WR52_13220	COG0697	spore germination
WR52_13260	COG2223	nitrite transmembrane transporter activity
WR52_13280	COG0592	DNA-directed DNA polymerase activity
WR52_13310	COG0251	oxidation-reduction process
WR52_13315	COG3878	Protein conserved in bacteria
WR52_13335	COG4667	esterase of the alpha-beta hydrolase superfamily
WR52_13375	COG0322	excinuclease ABC activity
WR52_13415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WR52_13465	COG1073	alpha beta
WR52_13475	COG0076	glutamate decarboxylase activity
WR52_13490	COG1523	belongs to the glycosyl hydrolase 13 family
WR52_13495	COG3227	Zinc metalloprotease (Elastase)
WR52_13520	COG0201	protein transport
WR52_13525	COG0697	spore germination
WR52_13530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WR52_13540	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WR52_13570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WR52_13585	COG2959	enzyme of heme biosynthesis
WR52_13590	COG3409	Peptidoglycan-binding domain 1 protein
WR52_13590	COG3773	Cell wall hydrolase
WR52_13625	COG1309	transcriptional regulator
WR52_13655	COG3284	Transcriptional regulator
WR52_13675	COG1349	DNA-binding transcription factor activity
WR52_13690	COG1959	2 iron, 2 sulfur cluster binding
WR52_13705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WR52_13710	COG0508	dehydrogenase complex catalyzes the overall conversion of
WR52_13715	COG0022	dehydrogenase e1 component
WR52_13720	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WR52_13730	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_13760	COG4176	ABC-type proline glycine betaine transport system permease component
WR52_13765	COG0517	IMP dehydrogenase activity
WR52_13765	COG4175	Glycine betaine
WR52_13775	COG0740	serine-type endopeptidase activity
WR52_13795	COG2153	protein acetylation
WR52_13800	COG3397	chitin binding
WR52_13840	COG2205	protein histidine kinase activity
WR52_13845	COG2226	methyltransferase
WR52_13850	COG2315	Protein conserved in bacteria
WR52_13900	COG3973	AAA domain
WR52_13915	COG0514	ATP-dependent DNA helicase (RecQ)
WR52_13955	COG4637	Psort location Cytoplasmic, score
WR52_13970	COG3397	chitin binding
WR52_13985	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WR52_13990	COG1115	amino acid carrier protein
WR52_13995	COG1012	belongs to the aldehyde dehydrogenase family
WR52_14000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WR52_14010	COG3938	Belongs to the proline racemase family
WR52_14015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WR52_14060	COG1078	dGTPase activity
WR52_14065	COG0586	Pfam SNARE associated Golgi protein
WR52_14075	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
WR52_14085	COG4166	transmembrane transport
WR52_14095	COG4948	Mandelate Racemase Muconate Lactonizing
WR52_14110	COG0667	Aldo Keto reductase
WR52_14155	COG5002	protein histidine kinase activity
WR52_14155	COG3850	Histidine kinase
WR52_14160	COG0745	RESPONSE REGULATOR receiver
WR52_14185	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
WR52_14195	COG1164	Oligoendopeptidase f
WR52_14200	COG1307	EDD domain protein, DegV family
WR52_14225	COG2814	Major facilitator Superfamily
WR52_14235	COG1664	Polymer-forming cytoskeletal
WR52_14240	COG0789	Transcriptional regulator
WR52_14245	COG4533	DNA binding
WR52_14250	COG0477	Major facilitator Superfamily
WR52_14250	COG2814	Major facilitator Superfamily
WR52_14270	COG2261	transglycosylase associated protein
WR52_14285	COG2226	methyltransferase
WR52_14305	COG2801	Transposase and inactivated derivatives
WR52_14330	COG0436	Aminotransferase
WR52_14335	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WR52_14345	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
WR52_14360	COG1131	(ABC) transporter
WR52_14415	COG0628	permease
WR52_14430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WR52_14435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WR52_14480	COG2746	aminoglycoside 3-N-acetyltransferase activity
WR52_14490	COG0697	spore germination
WR52_14510	COG4912	Dna alkylation repair
WR52_14515	COG0346	lactoylglutathione lyase activity
WR52_14530	COG0861	Integral membrane protein TerC family
WR52_14535	COG1368	sulfuric ester hydrolase activity
WR52_14540	COG0488	(ABC) transporter
WR52_14545	COG2409	Drug exporters of the RND superfamily
WR52_14545	COG1033	growth of symbiont in host cell
WR52_14550	COG1309	transcriptional regulator
WR52_14565	COG0287	Prephenate dehydrogenase
WR52_14580	COG1605	Chorismate mutase
WR52_14580	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
WR52_14625	COG1388	LysM domain
WR52_14625	COG3584	3D domain protein
WR52_14635	COG0346	lactoylglutathione lyase activity
WR52_14675	COG1172	Belongs to the binding-protein-dependent transport system permease family
WR52_14685	COG2390	Transcriptional regulator
WR52_14690	COG1070	Carbohydrate kinase
WR52_14705	COG2329	Antibiotic biosynthesis monooxygenase
WR52_14725	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WR52_14740	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
WR52_14745	COG4187	Peptidase family M20/M25/M40
WR52_14750	COG1414	Transcriptional regulator
WR52_14755	COG0833	amino acid
WR52_14765	COG3239	Fatty acid desaturase
WR52_14775	COG2720	vancomycin resistance protein
WR52_14780	COG1785	Belongs to the alkaline phosphatase family
WR52_14790	COG3655	Transcriptional regulator
WR52_14810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WR52_14815	COG0346	lactoylglutathione lyase activity
WR52_14840	COG0714	Associated with various cellular activities
WR52_14865	COG0463	Glycosyl transferase, family 2
WR52_14895	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WR52_14900	COG0753	catalase activity
WR52_14920	COG2801	Transposase and inactivated derivatives
WR52_14950	COG0714	Associated with various cellular activities
WR52_15055	COG0778	Nitroreductase
WR52_15060	COG1846	Transcriptional regulator
WR52_15080	COG0179	Fumarylacetoacetate (FAA) hydrolase
WR52_15090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WR52_15100	COG0318	PFAM AMP-dependent synthetase and ligase
WR52_15105	COG0183	Belongs to the thiolase family
WR52_15110	COG1024	Enoyl-CoA hydratase
WR52_15115	COG1250	3-hydroxyacyl-CoA dehydrogenase
WR52_15125	COG2508	Transcriptional regulator
WR52_15130	COG2814	Major facilitator Superfamily
WR52_15135	COG1574	metal-dependent hydrolase with the TIM-barrel fold
WR52_15170	COG0456	acetyltransferase
WR52_15185	COG0697	spore germination
WR52_15190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WR52_15230	COG0730	response to heat
WR52_15240	COG0833	amino acid
WR52_15250	COG4335	DNA alkylation repair
WR52_15310	COG1984	allophanate hydrolase subunit 2
WR52_15315	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
WR52_15320	COG1414	Transcriptional regulator
WR52_15330	COG3142	Participates in the control of copper homeostasis
WR52_15335	COG0640	Transcriptional regulator
WR52_15345	COG1960	acyl-CoA dehydrogenase activity
WR52_15380	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
WR52_15400	COG3848	Pyruvate phosphate dikinase
WR52_15400	COG0574	Belongs to the PEP-utilizing enzyme family
WR52_15405	COG2267	carboxylic ester hydrolase activity
WR52_15420	COG1124	(ABC) transporter
WR52_15425	COG0444	Belongs to the ABC transporter superfamily
WR52_15430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WR52_15435	COG0601	transmembrane transport
WR52_15440	COG0747	negative chemotaxis
WR52_15460	COG0596	Alpha beta hydrolase
WR52_15465	COG4990	cell redox homeostasis
WR52_15470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WR52_15485	COG5577	PFAM Coat F domain
WR52_15490	COG3403	YqcI/YcgG family
WR52_15495	COG1280	lysine exporter protein (LysE YggA)
WR52_15500	COG1113	amino acid transport
WR52_15530	COG1063	alcohol dehydrogenase
WR52_15535	COG1027	Aspartate ammonia-lyase
WR52_15540	COG0252	asparaginase activity
WR52_15545	COG1396	sequence-specific DNA binding
WR52_15565	COG5002	protein histidine kinase activity
WR52_15590	COG2207	Transcriptional regulator
WR52_15600	COG0322	excinuclease ABC activity
WR52_15605	COG0531	amino acid
WR52_15610	COG1114	Component of the transport system for branched-chain amino acids
WR52_15615	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
WR52_15625	COG0281	malic enzyme
WR52_15640	COG0531	amino acid
WR52_15645	COG0697	spore germination
WR52_15650	COG0784	Response regulator, receiver
WR52_15655	COG4191	Histidine kinase
WR52_15665	COG1115	amino acid carrier protein
WR52_15700	COG0737	Belongs to the 5'-nucleotidase family
WR52_15705	COG2267	carboxylic ester hydrolase activity
WR52_15710	COG1335	isochorismatase
WR52_15730	COG0583	DNA-binding transcription factor activity
WR52_15735	COG1846	Transcriptional regulator
WR52_15740	COG0598	Magnesium transport protein CorA
WR52_15760	COG1073	alpha beta
WR52_15780	COG0415	Belongs to the DNA photolyase family
WR52_15785	COG0288	reversible hydration of carbon dioxide
WR52_15795	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WR52_15800	COG5609	conserved protein (DUF2294)
WR52_15805	COG0726	polysaccharide deacetylase
WR52_15810	COG0456	acetyltransferase
WR52_15815	COG1575	Belongs to the MenA family. Type 1 subfamily
WR52_15825	COG0798	PFAM Bile acid sodium symporter
WR52_15830	COG0346	lactoylglutathione lyase activity
WR52_15835	COG0640	Transcriptional regulator
WR52_15865	COG0745	RESPONSE REGULATOR receiver
WR52_15895	COG2814	Major facilitator Superfamily
WR52_15905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WR52_15905	COG3320	Male sterility
WR52_15915	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_15920	COG1522	sequence-specific DNA binding
WR52_15935	COG0346	lactoylglutathione lyase activity
WR52_15980	COG0814	amino acid
WR52_15995	COG3409	Peptidoglycan-binding domain 1 protein
WR52_15995	COG5632	N-Acetylmuramoyl-L-alanine amidase
WR52_16000	COG0583	DNA-binding transcription factor activity
WR52_16040	COG0745	RESPONSE REGULATOR receiver
WR52_16045	COG3850	Histidine kinase
WR52_16045	COG5002	protein histidine kinase activity
WR52_16095	COG2814	Major facilitator Superfamily
WR52_16105	COG2515	1-aminocyclopropane-1-carboxylate deaminase
WR52_16120	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
WR52_16140	COG0577	efflux transmembrane transporter activity
WR52_16160	COG5002	protein histidine kinase activity
WR52_16160	COG3850	Histidine kinase
WR52_16170	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WR52_16175	COG5002	protein histidine kinase activity
WR52_16180	COG0745	RESPONSE REGULATOR receiver
WR52_16185	COG4990	cell redox homeostasis
WR52_16195	COG1619	proteins homologs of microcin C7 resistance protein MccF
WR52_16210	COG0561	phosphatase activity
WR52_16220	COG1609	Transcriptional regulator
WR52_16225	COG0457	Tetratricopeptide repeat
WR52_16255	COG0534	Mate efflux family protein
WR52_16270	COG2814	Major facilitator Superfamily
WR52_16275	COG1309	transcriptional regulator
WR52_16280	COG1522	sequence-specific DNA binding
WR52_16285	COG0531	amino acid
WR52_16300	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WR52_16320	COG0662	Cupin 2, conserved barrel domain protein
WR52_16325	COG2207	Transcriptional regulator
WR52_16325	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WR52_16340	COG3409	Peptidoglycan-binding domain 1 protein
WR52_16340	COG5632	N-Acetylmuramoyl-L-alanine amidase
WR52_16445	COG5444	nuclease activity
WR52_16465	COG2849	repeat protein
WR52_16470	COG5444	nuclease activity
WR52_16510	COG1876	peptidase activity
WR52_16515	COG2843	Capsule synthesis protein
WR52_16525	COG0477	Major facilitator Superfamily
WR52_16540	COG1846	Transcriptional regulator
WR52_16545	COG2814	Major facilitator Superfamily
WR52_16555	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
WR52_16560	COG1131	(ABC) transporter
WR52_16580	COG2076	Multidrug Resistance protein
WR52_16585	COG1309	transcriptional regulator
WR52_16600	COG2801	Transposase and inactivated derivatives
WR52_16615	COG2031	fatty acid transporter
WR52_16625	COG2249	NAD(P)H dehydrogenase (quinone) activity
WR52_16675	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
WR52_16680	COG1288	antiporter activity
WR52_16685	COG2356	endonuclease I
WR52_16705	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
WR52_16725	COG1733	regulation of RNA biosynthetic process
WR52_16730	COG0778	Nitroreductase
WR52_16760	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_16770	COG1131	(ABC) transporter
WR52_16795	COG1011	Hydrolase
WR52_16825	COG0180	Tryptophanyl-tRNA synthetase
WR52_16835	COG0628	permease
WR52_16895	COG1253	flavin adenine dinucleotide binding
WR52_16900	COG0789	Transcriptional regulator
WR52_16910	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
WR52_16935	COG0697	spore germination
WR52_16945	COG1357	PFAM Pentapeptide repeats (8 copies)
WR52_16950	COG3813	Protein conserved in bacteria
WR52_16955	COG2706	6-phosphogluconolactonase activity
WR52_16960	COG1070	Carbohydrate kinase
WR52_16970	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WR52_16975	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
WR52_16985	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
WR52_16990	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
WR52_16995	COG0604	alcohol dehydrogenase
WR52_17000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WR52_17010	COG0604	alcohol dehydrogenase
WR52_17025	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_17040	COG0840	transmembrane signaling receptor activity
WR52_17050	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WR52_17050	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WR52_17055	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WR52_17060	COG1733	regulation of RNA biosynthetic process
WR52_17080	COG2801	Transposase and inactivated derivatives
WR52_17085	COG0656	L-ascorbic acid biosynthetic process
WR52_17090	COG2814	Major facilitator Superfamily
WR52_17110	COG1846	Transcriptional regulator
WR52_17115	COG0814	amino acid
WR52_17145	COG1733	regulation of RNA biosynthetic process
WR52_17150	COG2188	Transcriptional regulator
WR52_17155	COG0673	inositol 2-dehydrogenase activity
WR52_17160	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WR52_17165	COG1733	regulation of RNA biosynthetic process
WR52_17170	COG1733	regulation of RNA biosynthetic process
WR52_17190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WR52_17210	COG0384	phenazine biosynthesis protein PhzF
WR52_17215	COG0318	PFAM AMP-dependent synthetase and ligase
WR52_17220	COG2249	NAD(P)H dehydrogenase (quinone) activity
WR52_17225	COG1733	regulation of RNA biosynthetic process
WR52_17230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WR52_17250	COG2801	Transposase and inactivated derivatives
WR52_17260	COG0726	polysaccharide deacetylase
WR52_17270	COG1191	sigma factor activity
WR52_17330	COG1151	hydroxylamine reductase activity
WR52_17340	COG3409	Peptidoglycan-binding domain 1 protein
WR52_17340	COG3757	hydrolase, family 25
WR52_17375	COG2072	flavoprotein involved in K transport
WR52_17410	COG1113	amino acid transport
WR52_17415	COG2814	Major facilitator Superfamily
WR52_17450	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
WR52_17455	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
WR52_17465	COG1247	-acetyltransferase
WR52_17470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WR52_17475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WR52_17480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WR52_17485	COG3739	integral membrane protein
WR52_17520	COG0583	DNA-binding transcription factor activity
WR52_17540	COG1193	negative regulation of DNA recombination
WR52_17555	COG2162	N-hydroxyarylamine O-acetyltransferase activity
WR52_17560	COG1164	Oligoendopeptidase f
WR52_17565	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WR52_17590	COG0584	glycerophosphoryl diester phosphodiesterase
WR52_17605	COG0640	Transcriptional regulator
WR52_17610	COG0604	alcohol dehydrogenase
WR52_17620	COG0457	Tetratricopeptide repeat
WR52_17630	COG2808	Putative FMN-binding domain
WR52_17645	COG0277	FAD linked oxidase domain protein
WR52_17680	COG3852	Histidine kinase
WR52_17690	COG1285	pathogenesis
WR52_17700	COG2514	catechol 2,3-dioxygenase activity
WR52_17705	COG2720	vancomycin resistance protein
WR52_17735	COG1278	Cold shock
WR52_17745	COG0716	FMN binding
WR52_17755	COG0494	nUDIX hydrolase
WR52_17775	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_17785	COG0165	Argininosuccinate lyase
WR52_17800	COG4145	pantothenate transmembrane transporter activity
WR52_17810	COG1012	belongs to the aldehyde dehydrogenase family
WR52_17815	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_17825	COG1657	PFAM Prenyltransferase squalene oxidase
WR52_17830	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
WR52_17835	COG2962	Rard protein
WR52_17840	COG3326	Membrane
WR52_17855	COG0489	protein tyrosine kinase activity
WR52_17865	COG0314	molybdopterin synthase activity
WR52_17870	COG0303	'Molybdopterin
WR52_17875	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WR52_17880	COG2116	formate transmembrane transporter activity
WR52_17890	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
WR52_17895	COG5609	conserved protein (DUF2294)
WR52_17900	COG2427	Protein of unknown function (DUF1641)
WR52_17905	COG3383	formate dehydrogenase (NAD+) activity
WR52_17915	COG0697	spore germination
WR52_17960	COG2226	methyltransferase
WR52_17965	COG4166	transmembrane transport
WR52_17975	COG4166	transmembrane transport
WR52_17980	COG1301	dicarboxylic acid transport
WR52_17985	COG1316	TRANSCRIPTIONal
WR52_17995	COG1595	DNA-templated transcription, initiation
WR52_18005	COG1131	(ABC) transporter
WR52_18025	COG0673	inositol 2-dehydrogenase activity
WR52_18030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
WR52_18035	COG0187	DNA topoisomerase II activity
WR52_18045	COG1832	CoA-binding protein
WR52_18050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WR52_18055	COG0745	RESPONSE REGULATOR receiver
WR52_18075	COG4841	protein insertion into membrane
WR52_18080	COG0824	Thioesterase
WR52_18110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WR52_18125	COG1132	(ABC) transporter
WR52_18130	COG1132	(ABC) transporter
WR52_18135	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
WR52_18145	COG0726	polysaccharide deacetylase
WR52_18165	COG2211	Major facilitator Superfamily
WR52_18175	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WR52_18190	COG0183	Belongs to the thiolase family
WR52_18195	COG0318	PFAM AMP-dependent synthetase and ligase
WR52_18200	COG1268	BioY protein
WR52_18205	COG0318	PFAM AMP-dependent synthetase and ligase
WR52_18245	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WR52_18255	COG5002	protein histidine kinase activity
WR52_18260	COG0400	carboxylic ester hydrolase activity
WR52_18265	COG0346	lactoylglutathione lyase activity
WR52_18270	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WR52_18275	COG0069	glutamate synthase activity
WR52_18280	COG1902	pentaerythritol trinitrate reductase activity
WR52_18285	COG1329	Transcriptional regulator
WR52_18290	COG0010	Belongs to the arginase family
WR52_18345	COG4846	Membrane protein involved in cytochrome C biogenesis
WR52_18350	COG0785	Cytochrome C biogenesis protein
WR52_18370	COG1131	(ABC) transporter
WR52_18385	COG0583	DNA-binding transcription factor activity
WR52_18395	COG1346	cytolysis
WR52_18410	COG0730	response to heat
WR52_18435	COG1132	(ABC) transporter
WR52_18440	COG1132	(ABC) transporter
WR52_18465	COG3639	organic phosphonate transmembrane transporter activity
WR52_18475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WR52_18480	COG0737	Belongs to the 5'-nucleotidase family
WR52_18490	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WR52_18510	COG1695	Transcriptional regulator
WR52_18520	COG5632	N-Acetylmuramoyl-L-alanine amidase
WR52_18520	COG3409	Peptidoglycan-binding domain 1 protein
WR52_18520	COG1388	LysM domain
WR52_18525	COG0739	heme binding
WR52_18565	COG0174	glutamine synthetase
WR52_18570	COG0789	Transcriptional regulator
WR52_18575	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
WR52_18580	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WR52_18585	COG2860	membrane
WR52_18595	COG0464	growth
WR52_18615	COG2801	Transposase and inactivated derivatives
WR52_18635	COG1388	LysM domain
WR52_18635	COG3584	3D domain protein
WR52_18640	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
WR52_18640	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WR52_18640	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WR52_18645	COG1105	Belongs to the carbohydrate kinase PfkB family
WR52_18650	COG1349	DNA-binding transcription factor activity
WR52_18655	COG1979	alcohol dehydrogenase
WR52_18660	COG2322	membrane
WR52_18675	COG1113	amino acid transport
WR52_18690	COG1408	metallophosphoesterase
WR52_18695	COG2116	formate transmembrane transporter activity
WR52_18710	COG2217	Heavy metal translocating P-type atpase
WR52_18715	COG2608	mercury ion transmembrane transporter activity
WR52_18720	COG1937	Protein conserved in bacteria
WR52_18730	COG2819	hydrolase of the alpha beta superfamily
WR52_18735	COG1120	ATPase activity
WR52_18740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WR52_18745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WR52_18750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WR52_18755	COG0708	Exodeoxyribonuclease III
WR52_18760	COG2169	Transcriptional regulator
WR52_18765	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
WR52_18770	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
WR52_18780	COG2364	Membrane
WR52_18795	COG2267	carboxylic ester hydrolase activity
WR52_18800	COG5001	Diguanylate cyclase
WR52_18800	COG3300	MHYT domain
WR52_18820	COG1086	Polysaccharide biosynthesis protein
WR52_18840	COG1346	cytolysis
WR52_18850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WR52_18860	COG2188	Transcriptional regulator
WR52_18865	COG2723	6-phospho-beta-galactosidase activity
WR52_18875	COG1404	Belongs to the peptidase S8 family
WR52_18880	COG3773	Cell wall hydrolase
WR52_18890	COG1368	sulfuric ester hydrolase activity
WR52_18895	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
WR52_18920	COG4550	Control of competence regulator ComK, YlbF/YmcA
WR52_18930	COG1013	pyruvate-flavodoxin oxidoreductase activity
WR52_18935	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
WR52_18935	COG0674	pyruvate-flavodoxin oxidoreductase activity
WR52_18945	COG2359	stage V sporulation protein S
WR52_18950	COG1692	metallophosphoesterase
WR52_18975	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WR52_18980	COG1426	Protein conserved in bacteria
WR52_18995	COG0300	oxidoreductase activity
WR52_19000	COG0612	Peptidase, M16
WR52_19005	COG0612	Peptidase, M16
WR52_19030	COG2188	Transcriptional regulator
WR52_19045	COG0740	serine-type endopeptidase activity
WR52_19050	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
WR52_19065	COG0527	aspartate kinase activity
WR52_19070	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WR52_19075	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WR52_19205	COG0582	viral genome integration into host DNA
WR52_19215	COG2801	Transposase and inactivated derivatives
WR52_19225	COG0791	NLP P60 protein
WR52_19225	COG1388	LysM domain
WR52_19230	COG1388	LysM domain
WR52_19230	COG3584	3D domain protein
WR52_19250	COG0305	Participates in initiation and elongation during chromosome replication
WR52_19285	COG3620	sequence-specific DNA binding
WR52_19315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WR52_19320	COG1873	PFAM PRC-barrel domain
WR52_19325	COG0612	Peptidase, M16
WR52_19330	COG0726	polysaccharide deacetylase
WR52_19345	COG0196	riboflavin kinase activity
WR52_19360	COG1550	Protein conserved in bacteria
WR52_19370	COG1358	cellular component organization or biogenesis
WR52_19375	COG2740	Nucleic-acid-binding protein implicated in transcription termination
WR52_19380	COG0195	Participates in both transcription termination and antitermination
WR52_19400	COG0750	zinc metalloprotease
WR52_19410	COG4589	Belongs to the CDS family
WR52_19455	COG4974	Belongs to the 'phage' integrase family
WR52_19465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WR52_19470	COG0758	DNA mediated transformation
WR52_19475	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
WR52_19515	COG1837	Belongs to the UPF0109 family
WR52_19525	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WR52_19535	COG0552	protein localization to endoplasmic reticulum
WR52_19540	COG1196	nuclear chromosome segregation
WR52_19555	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_19560	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
WR52_19575	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WR52_19580	COG1461	Dihydroxyacetone kinase
WR52_19585	COG1302	Protein conserved in bacteria
WR52_19600	COG1564	THIamine pyrophosphokinase
WR52_19605	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WR52_19615	COG2815	serine threonine protein kinase
WR52_19615	COG0515	serine threonine protein kinase
WR52_19620	COG0631	protein serine/threonine phosphatase activity
WR52_19630	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WR52_19630	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WR52_19645	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
WR52_19650	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WR52_19670	COG1561	YicC-like family, N-terminal region
WR52_19675	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
WR52_19685	COG0006	proline dipeptidase activity
WR52_19705	COG3069	C4-dicarboxylate transmembrane transporter activity
WR52_19765	COG0564	pseudouridine synthase activity
WR52_19785	COG3599	regulation of cell shape
WR52_19790	COG2302	S4 RNA-binding domain
WR52_19795	COG0762	integral membrane protein
WR52_19805	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
WR52_19815	COG1873	PFAM PRC-barrel domain
WR52_19820	COG1191	sigma factor activity
WR52_19825	COG1191	sigma factor activity
WR52_19835	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
WR52_19840	COG0849	cell division
WR52_19860	COG0772	Belongs to the SEDS family
WR52_19880	COG0768	penicillin binding
WR52_19905	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
WR52_19925	COG1399	metal-binding, possibly nucleic acid-binding protein
WR52_20035	COG0740	serine-type endopeptidase activity
WR52_20045	COG4626	Terminase
WR52_20045	COG1802	Transcriptional regulator
WR52_20080	COG1674	ftsk spoiiie
WR52_20080	COG4980	gas vesicle protein
WR52_20085	COG0582	viral genome integration into host DNA
WR52_20150	COG2002	toxin-antitoxin pair type II binding
WR52_20180	COG1396	sequence-specific DNA binding
WR52_20220	COG0582	viral genome integration into host DNA
WR52_20230	COG3480	Lon protease (S16) C-terminal proteolytic domain
WR52_20235	COG1752	Esterase of the alpha-beta hydrolase superfamily
WR52_20240	COG3314	Sporulation integral membrane protein YlbJ
WR52_20250	COG0742	ribosomal rna small subunit methyltransferase
WR52_20265	COG3679	Belongs to the UPF0342 family
WR52_20270	COG0406	alpha-ribazole phosphatase activity
WR52_20285	COG2340	Cysteine-rich secretory protein family
WR52_20300	COG3336	cytochrome c oxidase
WR52_20335	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
WR52_20340	COG0772	Belongs to the SEDS family
WR52_20350	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
WR52_20355	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
WR52_20365	COG4896	Protein conserved in bacteria
WR52_20390	COG0483	inositol monophosphate 1-phosphatase activity
WR52_20410	COG1982	Orn Lys Arg decarboxylase major
WR52_20460	COG0022	dehydrogenase e1 component
WR52_20465	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WR52_20480	COG0561	phosphatase activity
WR52_20490	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
WR52_20495	COG0569	domain protein
WR52_20515	COG0583	DNA-binding transcription factor activity
WR52_20520	COG0517	IMP dehydrogenase activity
WR52_20530	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
WR52_20540	COG4703	Protein of unknown function (DUF1797)
WR52_20555	COG2200	EAL domain
WR52_20560	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_20565	COG1408	metallophosphoesterase
WR52_20610	COG2814	Major facilitator Superfamily
WR52_20635	COG3209	COG3209 Rhs family protein
WR52_20645	COG2205	protein histidine kinase activity
WR52_20655	COG0436	Aminotransferase
WR52_20660	COG1609	Transcriptional regulator
WR52_20665	COG3833	ABC-type maltose transport systems, permease component
WR52_20670	COG1175	transmembrane transport
WR52_20675	COG2182	Extracellular solute-binding protein
WR52_20685	COG0366	Alpha amylase catalytic
WR52_20690	COG3842	ATPase activity
WR52_20730	COG0183	Belongs to the thiolase family
WR52_20765	COG1695	Transcriptional regulator
WR52_20770	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_20790	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WR52_20795	COG0436	Aminotransferase
WR52_20830	COG2084	Dehydrogenase
WR52_20840	COG2199	diguanylate cyclase activity
WR52_20840	COG2203	Gaf domain
WR52_20845	COG0778	Nitroreductase
WR52_20870	COG2190	(PTS) system
WR52_20870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WR52_20870	COG1263	PTS System
WR52_20875	COG3711	transcriptional antiterminator
WR52_20895	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
WR52_20925	COG1547	Domain of unknown function (DUF309)
WR52_20930	COG0456	acetyltransferase
WR52_20935	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WR52_20940	COG4086	secreted protein
WR52_20945	COG0561	phosphatase activity
WR52_20950	COG0697	spore germination
WR52_20965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WR52_20990	COG0733	neurotransmitter:sodium symporter activity
WR52_21010	COG1686	Belongs to the peptidase S11 family
WR52_21015	COG1725	Transcriptional regulator
WR52_21020	COG1131	(ABC) transporter
WR52_21040	COG1846	Transcriptional regulator
WR52_21055	COG0598	Magnesium transport protein CorA
WR52_21080	COG4974	Belongs to the 'phage' integrase family
WR52_21090	COG0735	belongs to the Fur family
WR52_21095	COG1300	Membrane
WR52_21115	COG0667	Aldo Keto reductase
WR52_21120	COG0656	L-ascorbic acid biosynthetic process
WR52_21125	COG0456	acetyltransferase
WR52_21125	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
WR52_21135	COG0737	Belongs to the 5'-nucleotidase family
WR52_21135	COG4085	toxin activity
WR52_21135	COG1525	nuclease
WR52_21145	COG0596	Alpha beta hydrolase
WR52_21150	COG2056	Na+-H+ antiporter family
WR52_21155	COG1609	Transcriptional regulator
WR52_21160	COG0456	acetyltransferase
WR52_21165	COG1073	alpha beta
WR52_21180	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WR52_21180	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WR52_21185	COG0307	riboflavin synthase, alpha
WR52_21215	COG2226	methyltransferase
WR52_21215	COG1073	alpha beta
WR52_21230	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
WR52_21245	COG0737	Belongs to the 5'-nucleotidase family
WR52_21255	COG1522	sequence-specific DNA binding
WR52_21300	COG0300	oxidoreductase activity
WR52_21305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WR52_21310	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
WR52_21315	COG2801	Transposase and inactivated derivatives
WR52_21325	COG1760	l-serine dehydratase
WR52_21330	COG1760	l-serine dehydratase
WR52_21370	COG2195	Cleaves the N-terminal amino acid of tripeptides
WR52_21375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WR52_21390	COG1376	ErfK ybiS ycfS ynhG family protein
WR52_21395	COG4129	membrane
WR52_21400	COG1126	abc transporter atp-binding protein
WR52_21405	COG0765	amino acid transport
WR52_21410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WR52_21435	COG0772	Belongs to the SEDS family
WR52_21445	COG0508	dehydrogenase complex catalyzes the overall conversion of
WR52_21450	COG0022	dehydrogenase e1 component
WR52_21455	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WR52_21460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WR52_21470	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
WR52_21475	COG0280	phosphate acetyltransferase
WR52_21485	COG3290	protein histidine kinase activity
WR52_21485	COG3829	transcription factor binding
WR52_21495	COG0584	glycerophosphoryl diester phosphodiesterase
WR52_21500	COG3093	addiction module antidote protein HigA
WR52_21520	COG0750	zinc metalloprotease
WR52_21525	COG0497	DNA recombination
WR52_21535	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
WR52_21545	COG0142	geranyltranstransferase activity
WR52_21570	COG1302	Protein conserved in bacteria
WR52_21575	COG0439	Biotin carboxylase
WR52_21580	COG0511	ligase activity, forming carbon-carbon bonds
WR52_21625	COG3854	ATPases associated with a variety of cellular activities
WR52_21650	COG0006	proline dipeptidase activity
WR52_21665	COG3872	metal-dependent enzyme
WR52_21675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WR52_21690	COG1695	Transcriptional regulator
WR52_21710	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WR52_21720	COG1609	Transcriptional regulator
WR52_21730	COG2076	Multidrug Resistance protein
WR52_21735	COG2076	Multidrug Resistance protein
WR52_21770	COG1131	(ABC) transporter
WR52_21775	COG1725	Transcriptional regulator
WR52_21805	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WR52_21870	COG1459	type II secretion system
WR52_21875	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WR52_21930	COG0646	methionine synthase
WR52_21930	COG1410	methionine synthase
WR52_21935	COG0646	methionine synthase
WR52_21935	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
WR52_21940	COG0626	cystathionine gamma-synthase activity
WR52_21945	COG0626	cystathionine gamma-synthase activity
WR52_21965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WR52_21975	COG1940	carbohydrate kinase activity
WR52_21980	COG4483	Protein conserved in bacteria
WR52_21985	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
WR52_21995	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
WR52_22000	COG2801	Transposase and inactivated derivatives
WR52_22010	COG0704	Plays a role in the regulation of phosphate uptake
WR52_22020	COG0573	inorganic phosphate transmembrane transporter activity
WR52_22025	COG0573	inorganic phosphate transmembrane transporter activity
WR52_22030	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
WR52_22040	COG0477	Major facilitator Superfamily
WR52_22045	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WR52_22055	COG5521	maltodextrose utilization protein MalA
WR52_22070	COG0735	belongs to the Fur family
WR52_22075	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WR52_22080	COG1121	(ABC) transporter
WR52_22085	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WR52_22115	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
WR52_22120	COG2384	SAM-dependent methyltransferase
WR52_22130	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WR52_22135	COG0358	DNA primase activity
WR52_22150	COG0517	IMP dehydrogenase activity
WR52_22165	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
WR52_22170	COG0295	cytidine deaminase activity
WR52_22175	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
WR52_22185	COG1480	7TM receptor with intracellular HD hydrolase
WR52_22190	COG1702	phosphate starvation-inducible protein PhoH
WR52_22210	COG1610	YqeY-like protein
WR52_22220	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WR52_22225	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WR52_22255	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WR52_22260	COG1733	regulation of RNA biosynthetic process
WR52_22285	COG1466	dna polymerase III delta subunit
WR52_22295	COG0658	competence protein
WR52_22295	COG2333	competence protein COMEC
WR52_22300	COG2131	deaminase
WR52_22305	COG1555	photosystem II stabilization
WR52_22305	COG1596	polysaccharide export
WR52_22310	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
WR52_22315	COG2226	methyltransferase
WR52_22320	COG0799	negative regulation of ribosome biogenesis
WR52_22325	COG1713	HD superfamily hydrolase involved in NAD metabolism
WR52_22335	COG1534	Rna-binding protein
WR52_22345	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
WR52_22350	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
WR52_22365	COG1191	sigma factor activity
WR52_22385	COG0778	Nitroreductase
WR52_22390	COG2357	RelA SpoT domain protein
WR52_22400	COG1785	Belongs to the alkaline phosphatase family
WR52_22410	COG2267	carboxylic ester hydrolase activity
WR52_22455	COG2801	Transposase and inactivated derivatives
WR52_22470	COG3186	Phenylalanine-4-hydroxylase
WR52_22480	COG2514	catechol 2,3-dioxygenase activity
WR52_22485	COG2259	Doxx family
WR52_22525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WR52_22535	COG1012	belongs to the aldehyde dehydrogenase family
WR52_22535	COG1454	alcohol dehydrogenase
WR52_22540	COG0626	cystathionine gamma-synthase activity
WR52_22545	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
WR52_22570	COG0768	penicillin binding
WR52_22605	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
WR52_22635	COG0628	permease
WR52_22655	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WR52_22670	COG1104	cysteine desulfurase activity
WR52_22675	COG1959	2 iron, 2 sulfur cluster binding
WR52_22680	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WR52_22700	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
WR52_22725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WR52_22735	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WR52_22735	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
WR52_22740	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
WR52_22745	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WR52_22745	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WR52_22755	COG2244	polysaccharide biosynthetic process
WR52_22760	COG2323	membrane
WR52_22770	COG1862	Preprotein translocase
WR52_22800	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
WR52_22830	COG0157	Belongs to the NadC ModD family
WR52_22835	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
WR52_22840	COG1104	cysteine desulfurase activity
WR52_22845	COG1827	regulation of RNA biosynthetic process
WR52_22850	COG2258	MOSC domain
WR52_22855	COG0077	Prephenate dehydratase
WR52_22860	COG0577	efflux transmembrane transporter activity
WR52_22865	COG0577	efflux transmembrane transporter activity
WR52_22870	COG1136	(ABC) transporter
WR52_22875	COG5002	protein histidine kinase activity
WR52_22880	COG0745	RESPONSE REGULATOR receiver
WR52_22890	COG3290	protein histidine kinase activity
WR52_22900	COG2868	ribosomal protein
WR52_22910	COG1530	ribonuclease E activity
WR52_22915	COG1994	Peptidase M50
WR52_22920	COG0739	heme binding
WR52_22925	COG2894	cell division
WR52_22940	COG1792	Involved in formation and maintenance of cell shape
WR52_22945	COG1077	Cell shape determining protein MreB Mrl
WR52_22965	COG0285	dihydrofolate synthase activity
WR52_22980	COG1388	LysM domain
WR52_22990	COG0113	porphobilinogen synthase activity
WR52_22995	COG1587	Uroporphyrinogen-III synthase
WR52_23005	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WR52_23015	COG1846	Transcriptional regulator
WR52_23020	COG1764	response to oxidative stress
WR52_23035	COG0470	DNA polymerase III
WR52_23035	COG1067	ATP-dependent peptidase activity
WR52_23080	COG0622	Phosphoesterase
WR52_23085	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
WR52_23095	COG5401	PFAM Sporulation and spore germination
WR52_23115	COG1309	transcriptional regulator
WR52_23125	COG2197	response regulator
WR52_23130	COG2233	PERMEase
WR52_23135	COG0402	S-adenosylhomocysteine deaminase activity
WR52_23140	COG1983	PspC domain protein
WR52_23145	COG1396	sequence-specific DNA binding
WR52_23150	COG0697	spore germination
WR52_23160	COG1959	2 iron, 2 sulfur cluster binding
WR52_23165	COG1668	transmembrane transport
WR52_23170	COG4152	abc transporter atp-binding protein
WR52_23175	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
WR52_23180	COG1360	Flagellar Motor Protein
WR52_23185	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WR52_23190	COG1876	peptidase activity
WR52_23195	COG0824	Thioesterase
WR52_23200	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WR52_23205	COG1053	succinate dehydrogenase
WR52_23210	COG2009	succinate dehydrogenase
WR52_23215	COG1719	4-vinyl reductase, 4VR
WR52_23225	COG3118	belongs to the thioredoxin family
WR52_23230	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
WR52_23235	COG2086	electron transfer activity
WR52_23240	COG1024	Enoyl-CoA hydratase
WR52_23245	COG1309	transcriptional regulator
WR52_23250	COG0318	PFAM AMP-dependent synthetase and ligase
WR52_23280	COG2318	DinB family
WR52_23310	COG1131	(ABC) transporter
WR52_23315	COG2205	protein histidine kinase activity
WR52_23320	COG0745	RESPONSE REGULATOR receiver
WR52_23330	COG4895	conserved protein (DUF2196)
WR52_23335	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
WR52_23345	COG4509	Sortase family
WR52_23350	COG1120	ATPase activity
WR52_23365	COG5386	Cell surface protein
WR52_23375	COG5386	Cell surface protein
WR52_23380	COG1114	Component of the transport system for branched-chain amino acids
WR52_23385	COG1187	pseudouridine synthase activity
WR52_23400	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
WR52_23400	COG1796	DNA polymerase
WR52_23405	COG1286	toxin biosynthetic process
WR52_23450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WR52_23460	COG1418	mRNA catabolic process
WR52_23475	COG2814	Major facilitator Superfamily
WR52_23480	COG1566	PFAM secretion protein HlyD family protein
WR52_23485	COG1309	transcriptional regulator
WR52_23490	COG1363	Peptidase, m42
WR52_23515	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WR52_23530	COG1484	DNA-dependent DNA replication
WR52_23535	COG3611	Membrane attachment protein
WR52_23545	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
WR52_23550	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WR52_23555	COG0237	dephospho-CoA kinase activity
WR52_23560	COG1971	Probably functions as a manganese efflux pump
WR52_23570	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WR52_23570	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WR52_23575	COG5002	protein histidine kinase activity
WR52_23580	COG0745	RESPONSE REGULATOR receiver
WR52_23595	COG0538	isocitrate dehydrogenase activity
WR52_23600	COG0372	Belongs to the citrate synthase family
WR52_23615	COG0628	permease
WR52_23620	COG3030	protein affecting phage T7 exclusion by the F plasmid
WR52_23645	COG1725	Transcriptional regulator
WR52_23650	COG0281	malic enzyme
WR52_23655	COG0587	DNA-directed DNA polymerase activity
WR52_23670	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
WR52_23685	COG4109	DRTGG domain
WR52_23700	COG0006	proline dipeptidase activity
WR52_23730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WR52_23735	COG0662	Cupin 2, conserved barrel domain protein
WR52_23750	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_23755	COG0589	response to stress
WR52_23795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WR52_23820	COG0827	DNA restriction-modification system
WR52_23825	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
WR52_23830	COG3874	Sporulation protein YtfJ
WR52_23845	COG1574	metal-dependent hydrolase with the TIM-barrel fold
WR52_23855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WR52_23870	COG1104	cysteine desulfurase activity
WR52_23880	COG0583	DNA-binding transcription factor activity
WR52_23885	COG0697	spore germination
WR52_23890	COG1309	transcriptional regulator
WR52_23895	COG1956	GAF domain-containing protein
WR52_23900	COG0626	cystathionine gamma-synthase activity
WR52_23935	COG0110	maltose O-acetyltransferase activity
WR52_23940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WR52_23945	COG0454	-acetyltransferase
WR52_23950	COG0517	IMP dehydrogenase activity
WR52_23955	COG0123	including yeast histone deacetylase and acetoin utilization protein
WR52_23970	COG0745	RESPONSE REGULATOR receiver
WR52_23980	COG0666	response to abiotic stimulus
WR52_24010	COG1609	Transcriptional regulator
WR52_24020	COG1605	Chorismate mutase
WR52_24020	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
WR52_24025	COG4851	CamS sex pheromone cAM373 precursor
WR52_24030	COG3118	belongs to the thioredoxin family
WR52_24040	COG2309	aminopeptidase activity
WR52_24065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WR52_24070	COG0697	spore germination
WR52_24075	COG0789	Transcriptional regulator
WR52_24090	COG1674	ftsk spoiiie
WR52_24095	COG0860	N-Acetylmuramoyl-L-alanine amidase
WR52_24095	COG1388	LysM domain
WR52_24105	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WR52_24115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WR52_24120	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
WR52_24125	COG1363	Peptidase, m42
WR52_24135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WR52_24150	COG0510	thiamine kinase activity
WR52_24155	COG1523	belongs to the glycosyl hydrolase 13 family
WR52_24165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WR52_24170	COG1349	DNA-binding transcription factor activity
WR52_24175	COG1187	pseudouridine synthase activity
WR52_24180	COG2244	polysaccharide biosynthetic process
WR52_24185	COG2081	HI0933 family
WR52_24190	COG2814	Major facilitator Superfamily
WR52_24200	COG3832	glyoxalase III activity
WR52_24225	COG1329	Transcriptional regulator
WR52_24250	COG0314	molybdopterin synthase activity
WR52_24255	COG1763	Mo-molybdopterin cofactor biosynthetic process
WR52_24260	COG0303	'Molybdopterin
WR52_24270	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WR52_24275	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
WR52_24295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WR52_24305	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WR52_24345	COG2814	Major facilitator Superfamily
WR52_24350	COG0475	glutathione-regulated potassium exporter activity
WR52_24355	COG0490	domain, Protein
WR52_24360	COG0582	viral genome integration into host DNA
WR52_24370	COG1136	(ABC) transporter
WR52_24390	COG1242	4 iron, 4 sulfur cluster binding
WR52_24395	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
WR52_24400	COG1794	racemase activity, acting on amino acids and derivatives
WR52_24420	COG2267	carboxylic ester hydrolase activity
WR52_24425	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
WR52_24430	COG0671	phosphoesterase, PA-phosphatase related
WR52_24435	COG0438	transferase activity, transferring glycosyl groups
WR52_24520	COG5002	protein histidine kinase activity
WR52_24525	COG3852	Histidine kinase
WR52_24535	COG2267	carboxylic ester hydrolase activity
WR52_24540	COG1368	sulfuric ester hydrolase activity
WR52_24560	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
WR52_24565	COG1116	anion transmembrane transporter activity
WR52_24570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WR52_24595	COG0494	nUDIX hydrolase
WR52_24640	COG0288	reversible hydration of carbon dioxide
WR52_24650	COG1271	oxidase subunit
WR52_24655	COG1294	oxidase, subunit
WR52_24670	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WR52_24690	COG1842	Phage shock protein A
WR52_24720	COG5002	protein histidine kinase activity
WR52_24725	COG0745	RESPONSE REGULATOR receiver
WR52_24755	COG1597	lipid kinase activity
WR52_24790	COG0586	Pfam SNARE associated Golgi protein
WR52_24800	COG0577	efflux transmembrane transporter activity
WR52_24805	COG1136	(ABC) transporter
WR52_24810	COG3708	Transcriptional regulator
WR52_24810	COG2207	Transcriptional regulator
WR52_24820	COG5658	integral membrane protein
WR52_24825	COG0640	Transcriptional regulator
WR52_24830	COG0745	RESPONSE REGULATOR receiver
WR52_24835	COG2205	protein histidine kinase activity
WR52_24840	COG0577	efflux transmembrane transporter activity
WR52_24845	COG0577	efflux transmembrane transporter activity
WR52_24850	COG1136	(ABC) transporter
WR52_24855	COG0577	efflux transmembrane transporter activity
WR52_24890	COG3964	amidohydrolase
WR52_24910	COG4948	Mandelate Racemase Muconate Lactonizing
WR52_24925	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
WR52_24940	COG1169	isochorismate synthase
WR52_24945	COG1575	Belongs to the MenA family. Type 1 subfamily
WR52_24950	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
WR52_24955	COG1278	Cold shock
WR52_24980	COG0058	SHG alpha-glucan phosphorylase activity
WR52_24990	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
WR52_25100	COG0544	peptidyl-prolyl cis-trans isomerase activity
WR52_25140	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
WR52_25170	COG2155	Conserved Protein
WR52_25175	COG1098	S1 RNA binding domain
WR52_25180	COG0436	Aminotransferase
WR52_25185	COG1522	sequence-specific DNA binding
WR52_25190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WR52_25195	COG2267	carboxylic ester hydrolase activity
WR52_25205	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
WR52_25225	COG5018	Exonuclease
WR52_25230	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
WR52_25245	COG0423	glycine-tRNA ligase activity
WR52_25250	COG2050	protein possibly involved in aromatic compounds catabolism
WR52_25260	COG1268	BioY protein
WR52_25265	COG1210	Utp--glucose-1-phosphate uridylyltransferase
WR52_25270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WR52_25285	COG3584	3D domain protein
WR52_25300	COG1252	NADH dehydrogenase
WR52_25315	COG3708	Transcriptional regulator
WR52_25330	COG1683	Conserved Protein
WR52_25350	COG0316	Belongs to the HesB IscA family
WR52_25365	COG1252	NADH dehydrogenase
WR52_25375	COG2274	protein secretion by the type I secretion system
WR52_25380	COG0390	transport system, permease component
WR52_25385	COG2824	Alkylphosphonate utilization operon protein PhnA
WR52_25420	COG4837	Protein of unknown function (DUF1462)
WR52_25425	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
WR52_25435	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
WR52_25440	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
WR52_25450	COG2249	NAD(P)H dehydrogenase (quinone) activity
WR52_25460	COG0647	UMP catabolic process
WR52_25470	COG2445	Protein of unknown function DUF86
WR52_25475	COG1494	fructose-1,6-bisphosphatase
WR52_25500	COG4470	Protein conserved in bacteria
WR52_25510	COG0789	Transcriptional regulator
WR52_25515	COG4377	Putative membrane peptidase family (DUF2324)
WR52_25540	COG0739	heme binding
WR52_25550	COG3377	Domain of unknown function (DUF1805)
WR52_25555	COG0737	Belongs to the 5'-nucleotidase family
WR52_25560	COG0719	Fe-S assembly protein
WR52_25565	COG0822	iron-sulfur transferase activity
WR52_25570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
WR52_25575	COG0719	Fe-S assembly protein
WR52_25580	COG0396	ATPase activity
WR52_25585	COG1464	Belongs to the NlpA lipoprotein family
WR52_25590	COG1464	Belongs to the NlpA lipoprotein family
WR52_25595	COG2011	ABC-type metal ion transport system permease component
WR52_25610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WR52_25615	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
WR52_25625	COG1393	Belongs to the ArsC family
WR52_25645	COG0039	L-malate dehydrogenase activity
WR52_25665	COG1309	transcriptional regulator
WR52_25670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WR52_25675	COG1960	acyl-CoA dehydrogenase activity
WR52_25685	COG0183	Belongs to the thiolase family
WR52_25690	COG1024	Enoyl-CoA hydratase
WR52_25690	COG1250	3-hydroxyacyl-CoA dehydrogenase
WR52_25700	COG1686	Belongs to the peptidase S11 family
WR52_25715	COG0011	TIGRFAM Protein of
WR52_25720	COG0840	transmembrane signaling receptor activity
WR52_25735	COG2814	Major facilitator Superfamily
WR52_25740	COG0531	amino acid
WR52_25765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
WR52_25800	COG0586	Pfam SNARE associated Golgi protein
WR52_25810	COG1376	ErfK ybiS ycfS ynhG family protein
WR52_25815	COG0745	RESPONSE REGULATOR receiver
WR52_25820	COG5002	protein histidine kinase activity
WR52_25850	COG0840	transmembrane signaling receptor activity
WR52_25855	COG2151	metal-sulfur cluster biosynthetic enzyme
WR52_25860	COG3227	Zinc metalloprotease (Elastase)
WR52_25865	COG1741	Belongs to the pirin family
WR52_25880	COG0586	Pfam SNARE associated Golgi protein
WR52_25885	COG0475	glutathione-regulated potassium exporter activity
WR52_25890	COG0490	domain, Protein
WR52_25900	COG1115	amino acid carrier protein
WR52_25910	COG0783	Belongs to the Dps family
WR52_25925	COG1611	Belongs to the LOG family
WR52_25935	COG1528	Iron-storage protein
WR52_25945	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WR52_25950	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WR52_25955	COG1115	amino acid carrier protein
WR52_25960	COG1115	amino acid carrier protein
WR52_25965	COG2910	NAD(P)H-binding
WR52_25980	COG0656	L-ascorbic acid biosynthetic process
WR52_25985	COG2814	Major facilitator Superfamily
WR52_25990	COG1733	regulation of RNA biosynthetic process
WR52_26000	COG1252	NADH dehydrogenase
WR52_26055	COG0488	(ABC) transporter
WR52_26060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WR52_26070	COG3223	Belongs to the PsiE family
WR52_26130	COG0557	exoribonuclease II activity
WR52_26135	COG1647	Serine aminopeptidase, S33
WR52_26140	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
WR52_26145	COG1346	cytolysis
WR52_26180	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WR52_26195	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
WR52_26220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WR52_26235	COG2323	membrane
WR52_26245	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WR52_26255	COG0391	Required for morphogenesis under gluconeogenic growth conditions
WR52_26265	COG1051	belongs to the nudix hydrolase family
WR52_26275	COG0492	ferredoxin-NADP+ reductase activity
WR52_26280	COG0457	Tetratricopeptide repeat
WR52_26285	COG0110	maltose O-acetyltransferase activity
WR52_26305	COG1950	PFAM Membrane protein of
WR52_26315	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WR52_26320	COG0556	nucleotide-excision repair
WR52_26340	COG0789	Transcriptional regulator
WR52_26360	COG0583	DNA-binding transcription factor activity
WR52_26370	COG0655	NAD(P)H dehydrogenase (quinone) activity
WR52_26375	COG0488	(ABC) transporter
WR52_26385	COG1132	(ABC) transporter
WR52_26390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WR52_26395	COG3409	Peptidoglycan-binding domain 1 protein
WR52_26395	COG0793	Belongs to the peptidase S41A family
WR52_26400	COG2177	Part of the ABC transporter FtsEX involved in
WR52_26405	COG2884	Cell division ATP-binding protein ftsE
WR52_26420	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WR52_26435	COG1131	(ABC) transporter
WR52_26465	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
WR52_26470	COG1278	Cold shock
WR52_26475	COG1040	competence protein
WR52_26480	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
WR52_26485	COG0791	NLP P60 protein
WR52_26485	COG1388	LysM domain
WR52_26490	COG1733	regulation of RNA biosynthetic process
WR52_26495	COG1307	EDD domain protein, DegV family
WR52_26500	COG1739	Uncharacterized protein family UPF0029
WR52_26505	COG1316	TRANSCRIPTIONal
WR52_26510	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
WR52_26515	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
WR52_26520	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WR52_26530	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
WR52_26530	COG3933	PFAM sigma-54 factor interaction domain-containing protein
WR52_26550	COG1486	melibiose metabolic process
WR52_26555	COG1447	Phosphotransferase system cellobiose-specific component IIA
WR52_26560	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WR52_26570	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
WR52_26580	COG1447	Phosphotransferase system cellobiose-specific component IIA
WR52_26590	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WR52_26595	COG1301	dicarboxylic acid transport
WR52_26610	COG1511	domain protein
WR52_26615	COG0583	DNA-binding transcription factor activity
WR52_26620	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
WR52_26630	COG1271	oxidase subunit
WR52_26635	COG1294	oxidase, subunit
WR52_26640	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
WR52_26650	COG1620	l-lactate permease
WR52_26660	COG2389	metal-binding protein
WR52_26670	COG1368	sulfuric ester hydrolase activity
WR52_26680	COG1388	LysM domain
WR52_26680	COG0791	NLP P60 protein
WR52_26685	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WR52_26695	COG1215	transferase activity, transferring glycosyl groups
WR52_26705	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
WR52_26710	COG3584	3D domain protein
WR52_26710	COG1388	LysM domain
WR52_26735	COG4715	Zinc finger, swim domain protein
WR52_26740	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WR52_26770	COG1191	sigma factor activity
WR52_26780	COG0577	efflux transmembrane transporter activity
WR52_26785	COG1136	(ABC) transporter
WR52_26810	COG5002	protein histidine kinase activity
WR52_26815	COG0745	RESPONSE REGULATOR receiver
WR52_26820	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WR52_26825	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WR52_26845	COG0438	transferase activity, transferring glycosyl groups
WR52_26865	COG0438	transferase activity, transferring glycosyl groups
WR52_26880	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
WR52_26885	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WR52_26890	COG1210	Utp--glucose-1-phosphate uridylyltransferase
WR52_26895	COG4464	protein tyrosine phosphatase activity
WR52_26900	COG0489	protein tyrosine kinase activity
WR52_26905	COG3944	biosynthesis protein
WR52_26910	COG0489	protein tyrosine kinase activity
WR52_26925	COG1609	Transcriptional regulator
WR52_26935	COG0739	heme binding
WR52_26950	COG3279	Response regulator of the LytR AlgR family
WR52_26955	COG2385	sporulation resulting in formation of a cellular spore
WR52_26970	COG4836	Membrane
WR52_26975	COG1007	ATP synthesis coupled electron transport
WR52_26980	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WR52_26985	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
WR52_26995	COG0839	Belongs to the complex I subunit 6 family
WR52_27015	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WR52_27030	COG5001	Diguanylate cyclase
WR52_27030	COG3300	MHYT domain
WR52_27080	COG0356	it plays a direct role in the translocation of protons across the membrane
WR52_27115	COG0698	ribose 5-phosphate isomerase
WR52_27130	COG2259	Doxx family
WR52_27135	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
WR52_27150	COG0009	L-threonylcarbamoyladenylate synthase
WR52_27185	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
WR52_27190	COG1494	fructose-1,6-bisphosphatase
WR52_27210	COG4821	SIS domain
WR52_27220	COG3343	RNA polymerase activity
WR52_27230	COG1960	acyl-CoA dehydrogenase activity
WR52_27235	COG1960	acyl-CoA dehydrogenase activity
WR52_27240	COG1250	3-hydroxyacyl-CoA dehydrogenase
WR52_27245	COG0183	Belongs to the thiolase family
WR52_27250	COG0247	lactate metabolic process
WR52_27250	COG2181	nitrate reductase activity
WR52_27255	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WR52_27265	COG5001	Diguanylate cyclase
WR52_27265	COG3300	MHYT domain
WR52_27280	COG3227	Zinc metalloprotease (Elastase)
WR52_27285	COG2197	response regulator
WR52_27290	COG4585	Histidine kinase
WR52_27295	COG0842	Transport permease protein
WR52_27300	COG1131	(ABC) transporter
WR52_27305	COG0024	Methionine aminopeptidase
WR52_27315	COG2234	aminopeptidase activity
WR52_27345	COG4506	Protein conserved in bacteria
WR52_27350	COG1619	proteins homologs of microcin C7 resistance protein MccF
WR52_27370	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
WR52_27375	COG2814	Major facilitator Superfamily
WR52_27380	COG0789	Transcriptional regulator
WR52_27385	COG0584	glycerophosphoryl diester phosphodiesterase
WR52_27390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WR52_27400	COG1994	Peptidase M50
WR52_27410	COG1078	dGTPase activity
WR52_27415	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WR52_27420	COG1120	ATPase activity
WR52_27425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WR52_27430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WR52_27450	COG0280	phosphate acetyltransferase
WR52_27465	COG3773	Cell wall hydrolase
WR52_27475	COG2363	Small membrane protein
WR52_27485	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
WR52_27490	COG2233	PERMEase
WR52_27495	COG0561	phosphatase activity
WR52_27500	COG2814	Major facilitator Superfamily
WR52_27510	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
WR52_27515	COG1131	(ABC) transporter
WR52_27520	COG2755	lipolytic protein G-D-S-L family
WR52_27525	COG1609	Transcriptional regulator
WR52_27535	COG0460	homoserine dehydrogenase
WR52_27555	COG1011	Hydrolase
WR52_27560	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WR52_27570	COG2197	response regulator
WR52_27575	COG4585	Histidine kinase
WR52_27575	COG2203	Gaf domain
WR52_27580	COG0351	phosphomethylpyrimidine kinase
WR52_27585	COG3706	GGDEF domain
WR52_27590	COG2879	small protein
WR52_27595	COG1966	Carbon starvation protein
WR52_27600	COG3279	Response regulator of the LytR AlgR family
WR52_27605	COG0477	Major facilitator Superfamily
WR52_27615	COG0438	transferase activity, transferring glycosyl groups
WR52_27630	COG0840	transmembrane signaling receptor activity
WR52_27640	COG1607	acyl-coa hydrolase
WR52_27645	COG1216	Glycosyl transferase, family 2
WR52_27655	COG1216	Glycosyl transferase, family 2
WR52_27675	COG0488	(ABC) transporter
WR52_27680	COG1696	Membrane protein involved in D-alanine export
WR52_27690	COG1309	transcriptional regulator
WR52_27695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WR52_27700	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WR52_27700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WR52_27705	COG0628	permease
WR52_27725	COG3275	phosphorelay sensor kinase activity
WR52_27730	COG2814	Major facilitator Superfamily
WR52_27735	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
WR52_27740	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
WR52_27760	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WR52_27765	COG1272	protein, Hemolysin III
WR52_27785	COG1164	Oligoendopeptidase f
WR52_27805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WR52_27810	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
WR52_27815	COG4853	Protein conserved in bacteria
WR52_27825	COG5002	protein histidine kinase activity
WR52_27830	COG0745	RESPONSE REGULATOR receiver
WR52_27860	COG0305	Participates in initiation and elongation during chromosome replication
WR52_27870	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
WR52_27875	COG4241	membrane
WR52_27895	COG0012	GTP binding
WR52_27900	COG4481	Protein conserved in bacteria
WR52_27905	COG0668	transmembrane transport
WR52_27915	COG1475	DNA binding
WR52_27920	COG1192	Involved in chromosome partitioning
WR52_27945	COG1847	R3H domain protein
WR52_28015	COG0667	Aldo Keto reductase
WR52_28070	COG1609	Transcriptional regulator
WR52_28075	COG2814	Major facilitator Superfamily
WR52_28085	COG0673	inositol 2-dehydrogenase activity
WR52_28115	COG3718	enzyme involved in inositol metabolism
WR52_28150	COG3942	CHAP domain
WR52_28150	COG1388	LysM domain
WR52_28215	COG0457	Tetratricopeptide repeat
WR52_28230	COG0697	spore germination
WR52_28255	COG3397	chitin binding
WR52_28260	COG0823	Involved in the tonB-independent uptake of proteins
WR52_28295	COG0584	glycerophosphoryl diester phosphodiesterase
WR52_28310	COG1252	NADH dehydrogenase
WR52_28365	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
WR52_28390	COG1183	phosphatidylcholine synthase activity
WR52_28450	COG0463	Glycosyl transferase, family 2
WR52_28475	COG3443	Belongs to the bacterial solute-binding protein 9 family
WR52_28490	COG4974	Belongs to the 'phage' integrase family
WR52_28505	COG5549	protein import
WR52_28505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WR52_28535	COG1404	Belongs to the peptidase S8 family
WR52_28545	COG1404	Belongs to the peptidase S8 family
WR52_28570	COG2169	Transcriptional regulator
WR52_28575	COG0745	RESPONSE REGULATOR receiver
WR52_28605	COG0683	leucine binding
WR52_28610	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WR52_28625	COG3486	L-lysine 6-monooxygenase (NADPH) activity
WR52_28640	COG2801	Transposase and inactivated derivatives
WR52_28650	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
WR52_28685	COG1136	(ABC) transporter
WR52_28690	COG0577	efflux transmembrane transporter activity
WR52_28695	COG0456	acetyltransferase
WR52_28705	COG2184	nucleotidyltransferase activity
WR52_28715	COG2814	Major facilitator Superfamily
WR52_28720	COG1309	transcriptional regulator
WR52_28735	COG0814	amino acid
WR52_28740	COG1760	l-serine dehydratase
WR52_28745	COG1760	l-serine dehydratase
WR52_28755	COG0531	amino acid
WR52_28810	COG0577	efflux transmembrane transporter activity
WR52_28815	COG1136	(ABC) transporter
WR52_28835	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_28865	COG2816	NAD+ diphosphatase activity
WR52_28870	COG0457	Tetratricopeptide repeat
WR52_28870	COG0463	Glycosyl transferase, family 2
WR52_29010	COG1210	Utp--glucose-1-phosphate uridylyltransferase
WR52_29015	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
WR52_29020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WR52_29025	COG0438	transferase activity, transferring glycosyl groups
WR52_29040	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
WR52_29045	COG0438	transferase activity, transferring glycosyl groups
WR52_29050	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
WR52_29075	COG2323	membrane
WR52_29085	COG0671	phosphoesterase, PA-phosphatase related
WR52_29090	COG3647	Membrane
WR52_29105	COG4990	cell redox homeostasis
WR52_29145	COG1819	glycosyl
WR52_29195	COG0582	viral genome integration into host DNA
WR52_29205	COG2002	toxin-antitoxin pair type II binding
WR52_29270	COG0596	Alpha beta hydrolase
WR52_29300	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
WR52_29335	COG0741	lytic transglycosylase activity
WR52_29340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WR52_29365	COG1404	Belongs to the peptidase S8 family
WR52_29440	COG0457	Tetratricopeptide repeat
WR52_29450	COG5632	N-Acetylmuramoyl-L-alanine amidase
WR52_29545	COG1396	sequence-specific DNA binding
WR52_29555	COG0726	polysaccharide deacetylase
WR52_29570	COG5632	N-Acetylmuramoyl-L-alanine amidase
WR52_29570	COG3409	Peptidoglycan-binding domain 1 protein
WR52_29575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WR52_29610	COG0457	Tetratricopeptide repeat
WR52_29625	COG2801	Transposase and inactivated derivatives
WR52_29665	COG2003	Belongs to the UPF0758 family
WR52_29670	COG1396	sequence-specific DNA binding
WR52_29750	COG1024	Enoyl-CoA hydratase
WR52_29760	COG1216	Glycosyl transferase, family 2
WR52_29795	COG1396	sequence-specific DNA binding
WR52_29810	COG3391	amine dehydrogenase activity
WR52_29815	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
WR52_29820	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_29825	COG2089	acid synthase
WR52_29840	COG1028	Short-chain dehydrogenase reductase Sdr
WR52_29845	COG0463	Glycosyl transferase, family 2
WR52_29850	COG0463	Glycosyl transferase, family 2
WR52_29855	COG1086	Polysaccharide biosynthesis protein
WR52_29860	COG1088	dTDP-glucose 4,6-dehydratase activity
WR52_29865	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WR52_29870	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
WR52_29920	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
WR52_29935	COG1395	domain, Protein
WR52_29960	COG3316	Transposase and inactivated derivatives
WR52_29980	COG1192	Involved in chromosome partitioning
WR52_30015	COG2312	Erythromycin esterase
WR52_30060	COG3402	PFAM membrane-flanked domain
WR52_30075	COG1136	(ABC) transporter
WR52_30080	COG0577	efflux transmembrane transporter activity
WR52_30090	COG1725	Transcriptional regulator
WR52_30115	COG2732	(Barnase) inhibitor
WR52_30145	COG1192	Involved in chromosome partitioning
WR52_30180	COG2801	Transposase and inactivated derivatives
WR52_30200	COG2274	protein secretion by the type I secretion system
WR52_30200	COG3271	cysteine-type peptidase activity
WR52_30210	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
WR52_30215	COG2197	response regulator
WR52_30235	COG5002	protein histidine kinase activity
WR52_30240	COG0745	RESPONSE REGULATOR receiver
WR52_30290	COG0450	alkyl hydroperoxide reductase
WR52_30295	COG0833	amino acid
WR52_30305	COG1982	Orn Lys Arg decarboxylase major
WR52_30310	COG2249	NAD(P)H dehydrogenase (quinone) activity
WR52_30315	COG1733	regulation of RNA biosynthetic process
WR52_30320	COG0110	maltose O-acetyltransferase activity
WR52_30325	COG1733	regulation of RNA biosynthetic process
WR52_30350	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WR52_30420	COG0076	glutamate decarboxylase activity
WR52_30425	COG0318	PFAM AMP-dependent synthetase and ligase
WR52_30430	COG4555	ABC transporter
WR52_30520	COG0739	heme binding
WR52_30555	COG3118	belongs to the thioredoxin family