locus-tag class description GNE09_00015 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) GNE09_00055 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GNE09_00060 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GNE09_00065 ENOG4105CNN ABC, transporter GNE09_00070 ENOG4105C2J ABC transporter GNE09_00080 ENOG4108RVA ribokinase GNE09_00085 ENOG4105ETE Transcriptional regulator (LacI family GNE09_00090 ENOG4105C0R drug resistance transporter emrb qaca subfamily GNE09_00095 ENOG41067TZ transcriptional regulator, MarR family GNE09_00100 ENOG4105CXY transporter GNE09_00110 ENOG41068KF Universal stress protein GNE09_00115 ENOG4105CHH sulfate transporter GNE09_00130 ENOG4105BZU Histidine kinase GNE09_00135 ENOG4105NAE bifunctional deaminase-reductase domain protein GNE09_00160 ENOG4108YI8 ABC transporter GNE09_00195 ENOG4108IQI permease GNE09_00200 ENOG4105DRP amino acid AbC transporter GNE09_00205 ENOG4105EAD ABC transporter GNE09_00210 ENOG4105CT1 (ABC) transporter GNE09_00215 ENOG4105CDA abc transporter atp-binding protein GNE09_00220 ENOG4105BZG amino acid carrier protein GNE09_00225 ENOG4105CRN Aminoglycoside phosphotransferase GNE09_00230 ENOG4105E1K spore germination protein GNE09_00245 ENOG4105CG3 alpha amylase, catalytic region GNE09_00250 ENOG4105C5Y PTS System GNE09_00255 ENOG4107414 GntR family transcriptional regulator GNE09_00260 ENOG4105D5Q Arginine ornithine antiporter GNE09_00265 ENOG4105BZU Histidine kinase GNE09_00275 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GNE09_00280 ENOG4105GMT ATPase associated with various cellular activities aaa_5 GNE09_00295 ENOG4105EXW epimerase dehydratase GNE09_00310 ENOG4105E0A ABC, transporter GNE09_00315 ENOG4108IHU transport system permease protein GNE09_00320 ENOG4105DQ5 transport system permease protein GNE09_00325 ENOG4108MES Periplasmic binding protein GNE09_00330 ENOG4105DUX Transporter GNE09_00345 ENOG4105DAA L-lactate GNE09_00350 ENOG4108IJ0 Aspartate ammonia-lyase GNE09_00355 ENOG4105C37 (CBS) domain GNE09_00360 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase GNE09_00365 ENOG4105D9N nucleoside GNE09_00370 ENOG4108KGH TRANSCRIPTIONal GNE09_00375 ENOG41073R8 VanW family GNE09_00410 ENOG4105DAP Nicotinate phosphoribosyltransferase GNE09_00415 ENOG4105C59 p-type ATPase GNE09_00425 ENOG4105CUB amino acid GNE09_00445 ENOG4108JB9 formate dehydrogenase GNE09_00450 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GNE09_00470 ENOG4105BZU Histidine kinase GNE09_00480 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GNE09_00485 ENOG4108UZ3 Transporter GNE09_00495 ENOG4105C6K Malic enzyme GNE09_00505 ENOG4108MRH transcriptional regulatory protein GNE09_00530 ENOG4105US7 Histidine kinase GNE09_00535 ENOG4108STX response regulator GNE09_00540 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) GNE09_00545 ENOG4105BZ7 extracellular solute-binding protein family 1 GNE09_00550 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component GNE09_00555 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GNE09_00560 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GNE09_00565 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator GNE09_00595 ENOG4105C42 Type I secretion membrane fusion protein (HlyD GNE09_00620 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GNE09_00625 ENOG4108594 Permease of the drug metabolite transporter GNE09_00630 ENOG4105DUX Transporter GNE09_00640 ENOG4107ZQN disulfide bond GNE09_00655 ENOG4105ZX1 Transposase C GNE09_00660 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GNE09_00665 ENOG4108FPN Integrase GNE09_00680 ENOG4105D4T Citrate transporter GNE09_00685 ENOG4108V9W transcriptional regulatory protein GNE09_00690 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GNE09_00700 ENOG4105DZ6 Band 7 protein GNE09_00715 ENOG4105C94 Transporter GNE09_00730 ENOG4105CYN Serine protein kinase GNE09_00735 ENOG4105BZU Histidine kinase GNE09_00740 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) GNE09_00750 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) GNE09_00760 ENOG4108R9S DSBA oxidoreductase GNE09_00765 ENOG4108JQC penicillin-binding protein 1A GNE09_00885 ENOG4105G5W regulator Fur family GNE09_00890 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GNE09_00910 ENOG4108IUW ABC transporter GNE09_00920 ENOG4105CBC glutamate synthase GNE09_00925 ENOG4107NBY Membrane GNE09_00930 ENOG4105BZ1 (ABC) transporter GNE09_00950 ENOG4106BXE GNE09_00955 ENOG4105CEN a g-specific adenine glycosylase GNE09_00960 ENOG41067AE Membrane-bound metal-dependent hydrolase GNE09_00990 ENOG4105ECP epimerase GNE09_00995 ENOG4105CI2 imidazolone-5-propionate hydrolase GNE09_01015 ENOG4105F1A Pyruvate formate-lyase GNE09_01030 ENOG4105CKK Glycosyl transferase, family 2 GNE09_01035 ENOG4105C3I Nad-dependent epimerase dehydratase GNE09_01040 ENOG4107QQG Dehydrogenase GNE09_01045 ENOG4107R51 Glycosyl transferase, family 2 GNE09_01060 ENOG4108A04 Beta-lactamase GNE09_01070 ENOG4105CSV Glutaminase GNE09_01095 ENOG4108IQI permease GNE09_01105 ENOG4108JUB Transcriptional regulator GNE09_01115 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GNE09_01125 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GNE09_01160 ENOG4105UPD Calcium Proton GNE09_01165 ENOG410606W general stress protein GNE09_01180 ENOG4107ZTW SNARE associated Golgi GNE09_01200 ENOG4108IPJ Membrane GNE09_01205 ENOG4105C59 p-type ATPase GNE09_01210 ENOG4107U9T Pfam:Ribonuclease_BN GNE09_01220 ENOG4105KJF protein tyrosine phosphatase GNE09_01225 ENOG41068PA UPF0435 protein GNE09_01240 ENOG4108TTB tellurium resistance protein GNE09_01245 ENOG4107TS3 membrane protein, TerC GNE09_01250 ENOG4106FN3 tellurium resistance protein GNE09_01255 ENOG4106FN3 tellurium resistance protein GNE09_01260 ENOG4108N0M stress protein GNE09_01290 ENOG4105DEU major facilitator superfamily GNE09_01305 ENOG41062JF Transcriptional regulator GNE09_01335 ENOG4105C5H ABC transporter GNE09_01345 ENOG4105D2X ABC transporter substrate-binding protein GNE09_01350 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GNE09_01370 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GNE09_01385 ENOG4105C9U ATP-dependent DNA helicase RecQ GNE09_01400 ENOG4105CI1 PTS System GNE09_01410 ENOG4105DNP FAD linked oxidase domain protein GNE09_01420 ENOG4108W63 CRP FNR family transcriptional regulator GNE09_01425 ENOG4105C5B carbamate kinase GNE09_01435 ENOG4105DBV ornithine carbamoyltransferase GNE09_01450 ENOG4105C8Q Methyl-accepting chemotaxis GNE09_01455 ENOG4105CDA abc transporter atp-binding protein GNE09_01460 ENOG4105EAB amino acid AbC transporter GNE09_01465 ENOG4105E5Q amino acid AbC transporter GNE09_01480 ENOG4105D2S major facilitator superfamily GNE09_01485 ENOG410756H nucleotidyltransferase GNE09_01505 ENOG4105BZU Histidine kinase GNE09_01520 ENOG4106UIA GNE09_01525 ENOG4106UIA GNE09_01545 ENOG4108V5C ABC transporter GNE09_01550 ENOG4105DQ5 transport system permease protein GNE09_01555 ENOG4105EHG Permease protein GNE09_01560 ENOG4107W7X Aldolase GNE09_01565 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) GNE09_01570 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) GNE09_01575 ENOG4105D3R alkyl hydroperoxide reductase GNE09_01595 ENOG4105DFD Na H antiporter GNE09_01605 ENOG4105DTQ mandelate racemase muconate lactonizing GNE09_01620 ENOG4108W15 Protein of unknown function (DUF1456) GNE09_01630 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GNE09_01635 ENOG4105D9N nucleoside GNE09_01660 ENOG4105KPY Small multidrug resistance protein GNE09_01665 ENOG4105C26 Dehydrogenase GNE09_01675 ENOG4108JPW Aminotransferase GNE09_01685 ENOG4105CBD Diacylglycerol kinase GNE09_01705 ENOG4107I77 yiaA/B two helix domain GNE09_01710 ENOG410834F Transcriptional regulator GNE09_01730 ENOG4105D01 (LipO)protein GNE09_01735 ENOG4108UMI ABC transporter, permease GNE09_01740 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GNE09_01745 ENOG4108W2Y isochorismatase GNE09_01770 ENOG4105C4R Atp-dependent dna helicase GNE09_01795 ENOG4105C12 Phosphoribosylglycinamide synthetase GNE09_01805 ENOG4108V3E phosphoribosylglycinamide formyltransferase GNE09_01830 ENOG4105VR9 phosphoribosylformylglycinamidine synthase GNE09_01840 ENOG4105C83 adenylosuccinate lyase GNE09_01845 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit GNE09_01850 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GNE09_01870 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GNE09_01920 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GNE09_01940 ENOG4107ZXU DSBA oxidoreductase GNE09_01975 ENOG4105C7N Xanthine uracil vitamin C permease GNE09_01995 ENOG4108TYN CAAX amino terminal protease family protein GNE09_02010 ENOG4105C5H ABC transporter GNE09_02015 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GNE09_02020 ENOG410801F ribosomal-protein-alanine acetyltransferase GNE09_02025 ENOG41072GX Peptidase M22 Glycoprotease GNE09_02030 ENOG4105K8N protein family UPF0079, ATPase GNE09_02135 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) GNE09_02145 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GNE09_02150 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein GNE09_02175 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) GNE09_02180 ENOG4105CPF Cell wall formation (By similarity) GNE09_02185 ENOG4108SC4 )-transporter GNE09_02190 ENOG4105CUB amino acid GNE09_02200 ENOG4105ERH Fumarylacetoacetate hydrolase GNE09_02205 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase GNE09_02235 ENOG410667J hydrolase GNE09_02240 ENOG4108JQ7 (ABC) transporter GNE09_02245 ENOG4105C3U ABC transporter GNE09_02250 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GNE09_02260 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein GNE09_02270 ENOG4105C5H ABC transporter GNE09_02290 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) GNE09_02305 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) GNE09_02355 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family GNE09_02360 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GNE09_02365 ENOG4105E0C molybdate abc transporter GNE09_02385 ENOG4108J59 Extracellular solute-binding protein, family 5 GNE09_02390 ENOG4108J59 Extracellular solute-binding protein, family 5 GNE09_02410 ENOG4108JQ7 (ABC) transporter GNE09_02415 ENOG4105C3U ABC transporter GNE09_02420 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GNE09_02425 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GNE09_02445 ENOG4105C2C drug resistance transporter, Bcr CflA GNE09_02460 ENOG4105IQ5 FAD linked oxidase domain protein GNE09_02475 ENOG4105D01 (LipO)protein GNE09_02480 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GNE09_02485 ENOG4108UMI ABC transporter, permease GNE09_02490 ENOG4108PSK reductase GNE09_02510 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GNE09_02525 ENOG4107U5W ybbr family GNE09_02530 ENOG4105C8B TIGR00159 family GNE09_02610 ENOG4108NMV polysaccharide deacetylase GNE09_02625 ENOG4105D1F ATP-binding protein GNE09_02650 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GNE09_02655 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) GNE09_02665 ENOG4108JJB ABC transporter GNE09_02690 ENOG41067V7 50S ribosomal protein L36 GNE09_02700 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GNE09_02710 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GNE09_02735 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GNE09_02840 ENOG4105XPM ribosomal protein GNE09_02845 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GNE09_02855 ENOG4107Y49 methyltransferase GNE09_02880 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GNE09_02895 ENOG4105QIV RNA polymerase GNE09_02900 ENOG4105M0M Tetracycline resistance protein GNE09_02905 ENOG4105C2N RNA methyltransferase TrmH family group 3 GNE09_02920 ENOG4105D7W serine acetyltransferase GNE09_02940 ENOG4105CTP PilT protein domain protein GNE09_02950 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) GNE09_02965 ENOG4108Z0C Uvrb UvrC protein GNE09_03055 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GNE09_03065 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GNE09_03070 ENOG4105KRF dihydroneopterin aldolase GNE09_03075 ENOG4105EEI dihydropteroate synthase GNE09_03080 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 GNE09_03085 ENOG4105DDQ anthranilate synthase GNE09_03090 ENOG4105CRQ synthase (Component I) GNE09_03095 ENOG4105C6T cysteine synthase GNE09_03110 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GNE09_03115 ENOG4108UGV hypoxanthine phosphoribosyltransferase GNE09_03120 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GNE09_03140 ENOG41060GV RNA binding s1 domain protein GNE09_03155 ENOG4105VYY sporulation protein yabp GNE09_03160 ENOG41082I2 s4 domain protein GNE09_03165 ENOG4108IY2 MazG family GNE09_03175 ENOG4108M14 stage v sporulation protein t GNE09_03180 ENOG4108JA2 transcriptioN-repair coupling factor GNE09_03190 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GNE09_03195 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GNE09_03210 ENOG4105KME endoribonuclease L-psp GNE09_03215 ENOG4105DFT pur operon repressor GNE09_03230 ENOG4105W42 Veg protein GNE09_03235 ENOG4105XFA sporulation peptidase YabG GNE09_03245 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) GNE09_03250 ENOG4105F8V Hydrolase, tatD family GNE09_03255 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GNE09_03265 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GNE09_03275 ENOG41060K3 Methyltransferase GNE09_03285 ENOG4105MA4 psp1 domain protein GNE09_03290 ENOG4105FA2 dna polymerase iii GNE09_03300 ENOG4105CXN decarboxylase GNE09_03335 ENOG41067KS pro-sigma K processing GNE09_03355 ENOG4105C6E dna polymerase iii GNE09_03365 ENOG4108Z6B deaminase GNE09_03370 ENOG4105GTG Isochorismatase GNE09_03380 ENOG4105ZMH deoxynucleoside kinase GNE09_03415 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GNE09_03450 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GNE09_03465 ENOG410848D S4 domain protein YaaA GNE09_03490 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GNE09_03500 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) GNE09_03520 ENOG4107QJE Chromosome Partitioning Protein GNE09_03525 ENOG4105FA0 parb-like partition protein GNE09_03530 ENOG4108ZDA Sporulation protein YyaC GNE09_03535 ENOG4105D8X mechanosensitive ion channel GNE09_03540 ENOG4105VDK protein, conserved in bacteria GNE09_03545 ENOG4105C3G gtp-binding protein GNE09_03565 ENOG4108XMW Membrane GNE09_03570 ENOG4105BZR domain protein GNE09_03580 ENOG4105CDU Replicative dna helicase GNE09_03585 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GNE09_03610 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GNE09_03615 ENOG4105BZU Histidine kinase GNE09_03630 ENOG4105Q2H domain protein GNE09_03635 ENOG4105C0H protease GNE09_03650 ENOG4105BZU Histidine kinase GNE09_03665 ENOG4105DPN Oligoendopeptidase f GNE09_03670 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) GNE09_03675 ENOG4105C1J atp-dependent rna helicase GNE09_03685 ENOG4108UT2 hemolysin iii GNE09_03690 ENOG4105CMR udp-glucose 4-epimerase GNE09_03700 ENOG4105IW1 AmiS UreI transporter GNE09_03710 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GNE09_03725 ENOG4107RGD Major Facilitator superfamily GNE09_03730 ENOG4108HRK Histidine kinase GNE09_03735 ENOG4108NEV two component transcriptional regulator, LytTR family GNE09_03750 ENOG4106F5Q Membrane GNE09_03755 ENOG4105E0X reductase GNE09_03765 ENOG41067SE Tetr family transcriptional regulator GNE09_03770 ENOG4105C5H ABC transporter GNE09_03775 ENOG4108IG5 Transcriptional regulator GNE09_03785 ENOG4105CKK Glycosyl transferase, family 2 GNE09_03800 ENOG4105K64 Glycosyl transferase, family 2 GNE09_03815 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) GNE09_03820 ENOG4108S4H thioesterase Superfamily protein GNE09_03830 ENOG4106YBV Methyl-accepting chemotaxis GNE09_03835 ENOG4105EN6 Membrane GNE09_03845 ENOG4105CG5 Glycosyl transferase (Group 1 GNE09_03855 ENOG41079KZ Major Facilitator Superfamily GNE09_03860 ENOG4105DY9 regulatoR GNE09_03865 ENOG4105D22 carbon starvation protein GNE09_03870 ENOG4105VCD cytoplasmic protein GNE09_03875 ENOG4105BZU Histidine kinase GNE09_03880 ENOG4105DWF phosphomethylpyrimidine kinase GNE09_03885 ENOG4105BZU Histidine kinase GNE09_03890 ENOG4105WH1 Two component transcriptional regulator luxr family GNE09_03900 ENOG4108Y4K DNA-binding transcriptional activator GNE09_03920 ENOG4105D6E homoserine dehydrogenase GNE09_03935 ENOG41090WU lipolytic protein G-D-S-L family GNE09_03940 ENOG4105CJ1 ABC, transporter GNE09_03945 ENOG4108TU7 Inherit from COG: (ABC) transporter GNE09_03955 ENOG4105VCH membrane GNE09_03960 ENOG410667J hydrolase GNE09_03970 ENOG4107SVH Potassium channel protein GNE09_03990 ENOG4108VKI Cell wall hydrolase GNE09_04000 ENOG4107UEZ chlorite dismutase GNE09_04005 ENOG4108IJ2 phosphate acetyltransferase GNE09_04010 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) GNE09_04015 ENOG4108VCI transcription factor, rsfa family GNE09_04025 ENOG4105DQ5 transport system permease protein GNE09_04030 ENOG4105EHG Permease protein GNE09_04035 ENOG4105E0A ABC, transporter GNE09_04040 ENOG4108MES Periplasmic binding protein GNE09_04045 ENOG4105DCI Phosphohydrolase GNE09_04050 ENOG41069HH 4-oxalocrotonate tautomerase GNE09_04055 ENOG4108Z4T Peptidase M50 GNE09_04060 ENOG4108XFG YwhD family GNE09_04065 ENOG4105BZ4 penicillin-binding protein GNE09_04070 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GNE09_04075 ENOG4107SWG transcriptional regulator MERR family GNE09_04080 ENOG4105DXB Major Facilitator superfamily GNE09_04090 ENOG4105CYW agmatinase GNE09_04110 ENOG410684U Domain of unknown function (DUF1934) GNE09_04120 ENOG4105EMN RNA polymerase sigma factor GNE09_04140 ENOG4105IIU Aminopeptidase GNE09_04150 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) GNE09_04155 ENOG4108M15 ABC transporter GNE09_04160 ENOG4105KCT ABC transporter GNE09_04165 ENOG4105BZU Histidine kinase GNE09_04175 ENOG4105D4Y metalloprotease GNE09_04190 ENOG4105BZU Histidine kinase GNE09_04205 ENOG4105DF6 Fe-S oxidoreductase GNE09_04215 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GNE09_04220 ENOG4105C1G acyl-Coa dehydrogenase GNE09_04225 ENOG4105C1G acyl-Coa dehydrogenase GNE09_04260 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GNE09_04265 ENOG4105CBT Fructose-1,6-bisphosphatase GNE09_04270 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) GNE09_04285 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GNE09_04290 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GNE09_04295 ENOG4108ZXQ stage ii sporulation protein r GNE09_04305 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GNE09_04320 ENOG4107XC4 flavin reductase domain protein, FMN-binding GNE09_04325 ENOG4108VGI doxx family GNE09_04340 ENOG4108YZG isomerase GNE09_04345 ENOG4108UIC UPF0340 protein GNE09_04370 ENOG41062M3 atp synthase GNE09_04375 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) GNE09_04425 ENOG4105BZU Histidine kinase GNE09_04430 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GNE09_04440 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GNE09_04445 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GNE09_04470 ENOG4105D65 subunit l GNE09_04475 ENOG4105C8S subunit m GNE09_04480 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GNE09_04485 ENOG4106778 Protein of unknown function (DUF1146) GNE09_04505 ENOG4105DY9 regulatoR GNE09_04520 ENOG4105FRN stage II sporulation protein GNE09_04530 ENOG4105MT0 Sporulation transcriptional regulator spoiiid GNE09_04545 ENOG4107YJ4 chain length determinant protein GNE09_04550 ENOG4105HTX biosynthesis protein GNE09_04555 ENOG4107YJ4 chain length determinant protein GNE09_04560 ENOG4108RB3 Capsular polysaccharide biosynthesis protein GNE09_04565 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GNE09_04575 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GNE09_04580 ENOG4105D3Q Sugar transferase GNE09_04585 ENOG4105D7W serine acetyltransferase GNE09_04595 ENOG4105C5E polysaccharide biosynthesis protein GNE09_04605 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GNE09_04610 ENOG4108TMJ glycosyl transferase GNE09_04625 ENOG4105BZF Glycosyl transferase (Group 1 GNE09_04645 ENOG4108KGH TRANSCRIPTIONal GNE09_04655 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GNE09_04660 ENOG4105BZU Histidine kinase GNE09_04675 ENOG4105CXY transporter GNE09_04695 ENOG4105C19 ABC transporter GNE09_04700 ENOG4107RBB ABC transporter, permease GNE09_04710 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GNE09_04740 ENOG4105C0D helicase GNE09_04745 ENOG4105KBK Zinc finger, swim domain protein GNE09_04770 ENOG41069ER domain protein GNE09_04775 ENOG4105C94 Transporter GNE09_04780 ENOG4107R8N Glycosyl transferase, family 2 GNE09_04805 ENOG4105E0M Sulfatase GNE09_04815 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) GNE09_04855 ENOG4107RSM transcriptional regulator GNE09_04860 ENOG4105ECB domain protein GNE09_04880 ENOG4105VZJ PTS System GNE09_04890 ENOG4105VCP PTS System GNE09_04895 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) GNE09_04900 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GNE09_04910 ENOG4105CK1 PTS System GNE09_04915 ENOG4105VCP PTS System GNE09_04920 ENOG4105F8D glycoside hydrolase family 4 GNE09_04940 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GNE09_04950 ENOG4105ESV Glycosyl transferase, family 4 GNE09_04960 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GNE09_04970 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GNE09_04980 ENOG4105KVH Transcriptional regulator GNE09_04995 ENOG41081UC Inherit from COG: Competence protein GNE09_05000 ENOG4105VEQ Cold shock protein GNE09_05005 ENOG4105MS2 ribosomal subunit Interface protein GNE09_05035 ENOG4108RDQ ABC transporter GNE09_05060 ENOG4105CAK Cell division ATP-binding protein ftsE GNE09_05065 ENOG4105CRP Part of the ABC transporter FtsEX involved in GNE09_05070 ENOG4105CN1 protease GNE09_05080 ENOG4105BZ1 (ABC) transporter GNE09_05095 ENOG4108WS4 fmn reductase GNE09_05105 ENOG4105DUM transcriptional regulator, lysR family GNE09_05110 ENOG4105HMI Membrane GNE09_05140 ENOG4107TXC Transcriptional regulator GNE09_05155 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GNE09_05160 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GNE09_05170 ENOG41086DT Membrane protein of unknown function GNE09_05190 ENOG4108S4C acetyltransferase GNE09_05200 ENOG4105C3M thioredoxin reductase GNE09_05210 ENOG4108Z4K mutator MutT protein GNE09_05220 ENOG4105CHW UPF0052 protein GNE09_05230 ENOG4105KRI phosphocarrier protein (HPr GNE09_05235 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GNE09_05240 ENOG4108QY0 Membrane GNE09_05255 ENOG4105CZ3 stage V sporulation protein ad GNE09_05260 ENOG41090VF Stage v sporulation protein ac GNE09_05280 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GNE09_05330 ENOG41067MG lrgb family GNE09_05335 ENOG4105XZU Preprotein translocase, subunit SecG GNE09_05345 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GNE09_05380 ENOG4105CM4 permease protein GNE09_05385 ENOG4108IPW abc transporter atp-binding protein GNE09_05400 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) GNE09_05405 ENOG4108V2W Carbonate dehydratase GNE09_05425 ENOG4108W2Y isochorismatase GNE09_05435 ENOG4108VY7 phosphate-starvation-inducible protein PsiE GNE09_05445 ENOG4108MK9 spermidine N(1)-acetyltransferase GNE09_05450 ENOG4105C5H ABC transporter GNE09_05470 ENOG4105WMR Protein CrcB homolog GNE09_05485 ENOG4105C8Q Methyl-accepting chemotaxis GNE09_05495 ENOG4105D4A Cell wall formation (By similarity) GNE09_05500 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GNE09_05515 ENOG4105KVH Transcriptional regulator GNE09_05520 ENOG4105F27 Major Facilitator GNE09_05525 ENOG4105CV8 reductase GNE09_05540 ENOG4108RYK Nad-dependent epimerase dehydratase GNE09_05555 ENOG4105D9N nucleoside GNE09_05560 ENOG4105D9N nucleoside GNE09_05565 ENOG4105DHF Membrane GNE09_05580 ENOG4108URH decarboxylase GNE09_05595 ENOG4108RMU ferritin dps family protein GNE09_05605 ENOG4105NCW Trka-c domain protein GNE09_05610 ENOG4107S91 Sodium hydrogen exchanger GNE09_05615 ENOG4107T5V SNARE associated Golgi GNE09_05630 ENOG4105C2I pirin domain protein GNE09_05635 ENOG4105D4Y metalloprotease GNE09_05640 ENOG4105VG1 fes assembly suf system protein GNE09_05645 ENOG4105C8Q Methyl-accepting chemotaxis GNE09_05650 ENOG4105C8Q Methyl-accepting chemotaxis GNE09_05675 ENOG4105BZU Histidine kinase GNE09_05680 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GNE09_05685 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GNE09_05730 ENOG4107AYK membrAne GNE09_05740 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GNE09_05755 ENOG4107R7I amino acid GNE09_05760 ENOG4108SUT Major Facilitator Superfamily GNE09_05775 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer GNE09_05795 ENOG4105DZ1 carboxypeptidase GNE09_05810 ENOG4105CHU acetyl-coa acetyltransferase GNE09_05815 ENOG4105C1G acyl-Coa dehydrogenase GNE09_05820 ENOG4108W8B Beta-lactamase domain protein GNE09_05835 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GNE09_05855 ENOG41080E8 Transcriptional regulator, Spx MgsR family GNE09_05880 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GNE09_05885 ENOG4108UMI ABC transporter, permease GNE09_05890 ENOG4105D01 (LipO)protein GNE09_05895 ENOG4105D01 (LipO)protein GNE09_05900 ENOG4105C3K feS assembly ATPase SufC GNE09_05905 ENOG4105JRK feS assembly protein SufD GNE09_05910 ENOG4105C9B Cysteine desulfurase GNE09_05915 ENOG4108UNV SUF system FeS assembly protein, NifU family GNE09_05920 ENOG4105DIW FeS assembly protein SUFB GNE09_05925 ENOG4107R8B 5'-nucleotidase GNE09_05930 ENOG4105KZD Domain of unknown function (DUF1805) GNE09_05935 ENOG4108YTE sporulation protein YunB GNE09_05940 ENOG4105FAA peptidase M23 GNE09_05965 ENOG41090T1 Membrane GNE09_05970 ENOG4107TXC Transcriptional regulator GNE09_05975 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) GNE09_05980 ENOG4105MMD transcriptional regulator GNE09_05995 ENOG4105CBT Fructose-1,6-bisphosphatase GNE09_06015 ENOG4105DYS nad(p)h dehydrogenase (quinone) GNE09_06025 ENOG4105DAX Pfam:DUF2983 GNE09_06045 ENOG4108W5N phosphatidylglycerophosphatase a GNE09_06060 ENOG41083MR nifu domain-containing protein GNE09_06085 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA GNE09_06090 ENOG4105C4B ABC transporter, permease GNE09_06095 ENOG4108JJA ABC, transporter GNE09_06120 ENOG4108YX9 iron--sulfur cluster insertion protein erpA GNE09_06150 ENOG4105EWC Purine nucleoside phosphorylase GNE09_06175 ENOG4105CEP NADH dehydrogenase GNE09_06190 ENOG41069ER domain protein GNE09_06210 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GNE09_06225 ENOG4105KA0 thioesterase Superfamily protein GNE09_06230 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) GNE09_06245 ENOG4107R3E Citrate transporter GNE09_06255 ENOG4105Y38 Kinase-associated protein B GNE09_06265 ENOG4105C87 Aminotransferase class I and II GNE09_06275 ENOG4108MUZ hydrolase GNE09_06280 ENOG4105C5I Dehydrogenase GNE09_06285 ENOG4108ZB6 transcriptional regulator AsnC family GNE09_06290 ENOG4105CHM Aminotransferase GNE09_06300 ENOG4105WG9 Conserved Protein GNE09_06315 ENOG4107PBV potassium channel GNE09_06320 ENOG4105KT7 mgtC SapB transporter GNE09_06455 ENOG4108Q5F Tetr family transcriptional regulator GNE09_06460 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GNE09_06480 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) GNE09_06515 ENOG4105VEQ Cold shock protein GNE09_06525 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GNE09_06530 ENOG4105E4F Isochorismate synthase GNE09_06540 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) GNE09_06545 ENOG4108IPT Naphthoate synthase GNE09_06555 ENOG4105DTQ mandelate racemase muconate lactonizing GNE09_06585 ENOG41069H0 dihydroorotase EC 3.5.2.3 GNE09_06605 ENOG4105FDP GntR family transcriptional regulator GNE09_06610 ENOG4105C6Z Gluconate GNE09_06655 ENOG41082BM Transcriptional regulator, arsr family GNE09_06665 ENOG4105CJ1 ABC, transporter GNE09_06675 ENOG41086D8 Transcriptional regulator GNE09_06680 ENOG4105C19 ABC transporter GNE09_06695 ENOG4107ZTW SNARE associated Golgi GNE09_06705 ENOG4105BZU Histidine kinase GNE09_06755 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) GNE09_06760 ENOG4108UGV hypoxanthine phosphoribosyltransferase GNE09_06785 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GNE09_06790 ENOG4105BZU Histidine kinase GNE09_06795 ENOG4105N67 Proton-coupled thiamine transporter YuaJ GNE09_06820 ENOG41087YS Phage shock protein A GNE09_06865 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GNE09_06870 ENOG4105C4M (Ubiquinol oxidase) subunit I GNE09_06875 ENOG4108V2W Carbonate dehydratase GNE09_06900 ENOG41080TC multidrug resistance protein GNE09_06955 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component GNE09_06965 ENOG4105D2X ABC transporter substrate-binding protein GNE09_06980 ENOG4107T7U Sulfatase GNE09_06985 ENOG4107S9D Alpha beta hydrolase GNE09_06990 ENOG4105CH6 catalase GNE09_06995 ENOG4105BZU Histidine kinase GNE09_07000 ENOG4105BZU Histidine kinase GNE09_07080 ENOG4105EPU Molybdenum cofactor synthesis domain protein GNE09_07090 ENOG4105BZF Glycosyl transferase (Group 1 GNE09_07095 ENOG4105YVM Phosphoesterase, PA-phosphatase related GNE09_07100 ENOG4108Z0R Transferase GNE09_07105 ENOG4105E8V Alpha Beta Hydrolase Fold protein GNE09_07130 ENOG4105N5T Radical SAM Protein GNE09_07150 ENOG4105C19 ABC transporter GNE09_07165 ENOG4105NCW Trka-c domain protein GNE09_07170 ENOG4107S91 Sodium hydrogen exchanger GNE09_07175 ENOG410605W Major Facilitator GNE09_07215 ENOG4105DWV Homoserine O-trans-acetylase GNE09_07225 ENOG41085GJ domain protein GNE09_07245 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GNE09_07250 ENOG4105D06 uba thif-type nad fad binding protein GNE09_07260 ENOG4105CVM Molybdenum cofactor synthesis domain protein GNE09_07265 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein GNE09_07270 ENOG4108ZAF Molybdopterin GNE09_07285 ENOG4105CSC Glucose uptake protein GNE09_07290 ENOG4107EXU Short-chain dehydrogenase reductase Sdr GNE09_07295 ENOG4108VJ1 Transcriptional regulator (CarD family GNE09_07330 ENOG4105CBX hi0933 family GNE09_07345 ENOG4105YW5 deoR family transcriptional regulator GNE09_07350 ENOG4107QSE Dipeptidase GNE09_07360 ENOG4108IUM Glycogen debranching enzyme GNE09_07365 ENOG4108V15 phosphotransferase enzyme family GNE09_07380 ENOG4105C8F Beta-lactamase domain protein GNE09_07410 ENOG4108VDD TRNA binding domain protein GNE09_07445 ENOG4108IPJ Membrane GNE09_07465 ENOG4105C88 aminopeptidase GNE09_07485 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase GNE09_07500 ENOG4105ETE Transcriptional regulator (LacI family GNE09_07525 ENOG4105EP9 oxidoreductase GNE09_07530 ENOG4107SNB ankyrin repeat protein YahD GNE09_07535 ENOG4105BZU Histidine kinase GNE09_07540 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GNE09_07555 ENOG4105DGU Histone deacetylase GNE09_07560 ENOG4105W87 Cbs domain GNE09_07565 ENOG4105F1V Acetoin utilization protein GNE09_07575 ENOG4108UW5 maltose o-acetyltransferase GNE09_07585 ENOG4105EMN RNA polymerase sigma factor GNE09_07625 ENOG4105C28 cystathionine GNE09_07635 ENOG4105U5Y Transcriptional regulator GNE09_07645 ENOG4105RQF LysR family Transcriptional regulator GNE09_07670 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GNE09_07680 ENOG4105EFZ amidohydrolase GNE09_07695 ENOG4105KBJ sporulation protein ytfj GNE09_07700 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) GNE09_07710 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GNE09_07730 ENOG4108JYZ YitT family GNE09_07775 ENOG4107YZX Universal stress protein GNE09_07795 ENOG41082W1 Cupin 2, conserved barrel domain protein GNE09_07800 ENOG4105Z7P Acetyltransferase (GNAT) family GNE09_07835 ENOG4105DC7 peptidase M24 GNE09_07865 ENOG4105SFS phosphoesterase RecJ domain protein GNE09_07875 ENOG4105VV2 GNE09_07880 ENOG4105C0B DNA polymerase III (alpha subunit) GNE09_07885 ENOG4105C6K Malic enzyme GNE09_07890 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family GNE09_07915 ENOG4105FS0 cytoplasmic membrane protein GNE09_07920 ENOG4108REF Sporulation integral membrane protein ytvi GNE09_07930 ENOG4105BZN citrate synthase GNE09_07935 ENOG4108HMX isocitrate dehydrogenase (NADP) GNE09_07955 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GNE09_07960 ENOG4105BZU Histidine kinase GNE09_07965 ENOG4105C2M dna polymerase I GNE09_07970 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GNE09_07980 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GNE09_07985 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GNE09_07990 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) GNE09_08015 ENOG4108TDW sporulation protein YtxC GNE09_08020 ENOG4105C22 threonyL-tRNA synthetase GNE09_08025 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GNE09_08045 ENOG4105CN9 Peptidase m42 family protein GNE09_08050 ENOG4108JGH Tetr family transcriptional regulator GNE09_08055 ENOG4105CW7 secretion protein, HlyD family GNE09_08060 ENOG4105C0R drug resistance transporter emrb qaca subfamily GNE09_08085 ENOG4108RWN rrna methyltransferase GNE09_08095 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GNE09_08100 ENOG4105C5S asparaginyl-tRNA synthetase GNE09_08115 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GNE09_08130 ENOG4105DCG PHP domain protein GNE09_08140 ENOG4105FE9 pseudouridine synthase GNE09_08150 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) GNE09_08175 ENOG4105E0A ABC, transporter GNE09_08180 ENOG4105KFN sortase, SrtB family GNE09_08190 ENOG4105DR4 Methyltransferase GNE09_08200 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GNE09_08240 ENOG4105J76 Periplasmic binding protein GNE09_08250 ENOG4105CEY Amp-dependent synthetase and ligase GNE09_08255 ENOG4107Z3H Transcriptional regulator, TetR family GNE09_08260 ENOG41060WC Enoyl-CoA hydratase GNE09_08265 ENOG4105BZJ Electron transfer flavoprotein GNE09_08270 ENOG4105C10 Electron transfer flavoprotein GNE09_08275 ENOG4105K63 Thioredoxin GNE09_08300 ENOG4105E33 succinate dehydrogenase GNE09_08310 ENOG4108VXD carboxy-peptidase GNE09_08315 ENOG4105E14 MotA TolQ exbB proton channel GNE09_08320 ENOG4105ER2 Ompa motb domain protein GNE09_08325 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family GNE09_08330 ENOG4108IUX (ABC) transporter GNE09_08335 ENOG4105RHA ABC transporter, permease GNE09_08340 ENOG4108Z40 Transcriptional regulator GNE09_08345 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GNE09_08355 ENOG4108JCI Transcriptional regulator GNE09_08360 ENOG41067S9 phage shock protein C, PspC GNE09_08365 ENOG4105DZC cytosine deaminase GNE09_08375 ENOG4105PFC Transcriptional regulator GNE09_08385 ENOG4105KBX Transcriptional regulator, TetR family GNE09_08395 ENOG4108PCX Major Facilitator GNE09_08405 ENOG4108XJQ germination protein GNE09_08420 ENOG4105M59 Phosphodiesterase, mj0936 family GNE09_08440 ENOG4108QCI YvbH-like oligomerisation region GNE09_08465 ENOG4108IUQ atp-dependent protease GNE09_08485 ENOG4105K56 Transcriptional regulator GNE09_08510 ENOG4105D52 delta-aminolevulinic acid dehydratase GNE09_08520 ENOG41068KH stage VI sporulation protein D GNE09_08530 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GNE09_08535 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GNE09_08555 ENOG4105DFF Rod shape-determining protein mreb GNE09_08560 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) GNE09_08575 ENOG4107QMS site-determining protein GNE09_08590 ENOG4105C03 ribonuclease GNE09_08600 ENOG4105X36 (ribosomal) protein GNE09_08625 ENOG4105EWM Histidine kinase GNE09_08645 ENOG4105CQC Prephenate dehydratase GNE09_08655 ENOG4108RPX mosc domain containing protein GNE09_08670 ENOG4108IYU L-aspartate oxidase GNE09_08675 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GNE09_08705 ENOG4108HUF Transporter GNE09_08720 ENOG41061AI Protein of unknown function (DUF2905) GNE09_08735 ENOG4105VIE preprotein translocase, subunit YajC GNE09_08745 ENOG4108QG2 Membrane GNE09_08750 ENOG4105CKP Polysaccharide Biosynthesis Protein GNE09_08760 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GNE09_08765 ENOG41076HS cation diffusion facilitator family transporter GNE09_08770 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GNE09_08780 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GNE09_08795 ENOG4105CUT histidyl-tRNA synthetase GNE09_08805 ENOG4105CUZ uba thif-type nad fad binding protein GNE09_08810 ENOG4108VCI transcription factor, rsfa family GNE09_08815 ENOG4105D1H recombination factor protein RarA GNE09_08825 ENOG4105C3J Cysteine desulfurase GNE09_08830 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GNE09_08840 ENOG4105C7H Helicase, RecD TraA family GNE09_08845 ENOG41060CR GNE09_08860 ENOG4105C02 permease GNE09_08870 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GNE09_08890 ENOG4105HHA aminodeoxychorismate lyase GNE09_08900 ENOG4105XYU peptidase (U32 family) GNE09_08905 ENOG4105CFP Peptidase U32 GNE09_08915 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GNE09_08925 ENOG4107XRG penicillin-binding protein GNE09_08955 ENOG4105C28 cystathionine GNE09_08960 ENOG4108EKI Dehydrogenase GNE09_08970 ENOG4108V5C ABC transporter GNE09_08975 ENOG4105S6R Iron-hydroxamate transporter permease subunit GNE09_09015 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase GNE09_09025 ENOG4105MIR Phenylalanine 4-monooxygenase GNE09_09030 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin GNE09_09065 ENOG4108MUZ hydrolase GNE09_09070 ENOG4105KEG ribosomal-protein-alanine acetyltransferase GNE09_09075 ENOG4105G6Z alkaline phosphatase GNE09_09090 ENOG4108TVJ Nitroreductase GNE09_09110 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GNE09_09125 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase GNE09_09130 ENOG4105CQW ribosome biogenesis GTPase YqeH GNE09_09140 ENOG410812S Rna-binding protein GNE09_09150 ENOG4108WF2 Metal Dependent Phosphohydrolase GNE09_09160 ENOG4105DXX methyltransferase GNE09_09170 ENOG4105KQC Competence protein GNE09_09175 ENOG4108UK2 deaminase GNE09_09180 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 GNE09_09190 ENOG4105TQK DNA polymerase iii, delta' subunit GNE09_09215 ENOG4105KVH Transcriptional regulator GNE09_09220 ENOG4105CSA Coproporphyrinogen iii oxidase GNE09_09250 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GNE09_09255 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GNE09_09265 ENOG4105KTH gatB Yqey GNE09_09275 ENOG41068P3 sporulation protein YqfC GNE09_09285 ENOG4105C9A Phoh family GNE09_09290 ENOG4105CTJ Metal Dependent Phosphohydrolase GNE09_09300 ENOG4107YR5 Diacylglycerol kinase GNE09_09305 ENOG4105KG3 cytidine deaminase GNE09_09310 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GNE09_09340 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GNE09_09355 ENOG4105EGD dinuclear metal center protein, YbgI family GNE09_09380 ENOG41069ZM Protein of unknown function (DUF2624) GNE09_09385 ENOG4108JYZ YitT family GNE09_09390 ENOG4105FDK ABC transporter GNE09_09400 ENOG4105N80 Ferric uptake regulator, Fur family GNE09_09425 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GNE09_09435 ENOG4107RF6 penicillin-binding protein GNE09_09445 ENOG4105C8U phosphate abc transporter GNE09_09450 ENOG4105C8U phosphate abc transporter GNE09_09455 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GNE09_09460 ENOG4108UTW Plays a role in the regulation of phosphate uptake GNE09_09475 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase GNE09_09485 ENOG4105DKQ ROK family GNE09_09495 ENOG4105C5X domain protein GNE09_09515 ENOG4105C28 cystathionine GNE09_09520 ENOG4105C28 cystathionine GNE09_09530 ENOG4105C3R Methionine synthase GNE09_09535 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GNE09_09570 ENOG4107R6U sodium dicarboxylate symporter GNE09_09655 ENOG4105C0D helicase GNE09_09695 ENOG41080TC multidrug resistance protein GNE09_09720 ENOG4105WZW rhodanese family GNE09_09725 ENOG41082GG biotin lipoate A B protein ligase GNE09_09755 ENOG4107YBY Hydrolase GNE09_09765 ENOG4105CBJ Metal-dependent enzyme GNE09_09775 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GNE09_09780 ENOG4105DC7 peptidase M24 GNE09_09805 ENOG4105CD2 stage iii sporulation protein aa GNE09_09810 ENOG4105KR5 Stage iii sporulation protein GNE09_09815 ENOG4108CQH stage III sporulation protein AC GNE09_09820 ENOG4105KQ4 Stage iii sporulation protein ad GNE09_09830 ENOG410644B Stage III sporulation protein af GNE09_09855 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GNE09_09860 ENOG4108ZSR alkaline shock protein GNE09_09885 ENOG4105CTB Polyprenyl synthetase GNE09_09895 ENOG4105DX0 Hemolysin A GNE09_09900 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) GNE09_09905 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GNE09_09910 ENOG4105S1Z Stage IV sporulation protein B GNE09_09915 ENOG4107QQR Sporulation GNE09_09930 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GNE09_09940 ENOG4108JUB Transcriptional regulator GNE09_09950 ENOG4107RDP Dehydrogenase GNE09_09970 ENOG4105CPP Dehydrogenase, E1 component GNE09_09975 ENOG4105C7S Dehydrogenase GNE09_09985 ENOG4108QY0 Membrane GNE09_09995 ENOG4105G7B Protein of unknown function (DUF2992) GNE09_10005 ENOG4108HW3 (ABC) transporter GNE09_10010 ENOG4105E5Q amino acid AbC transporter GNE09_10015 ENOG4105CDA abc transporter atp-binding protein GNE09_10020 ENOG4108QEG Membrane GNE09_10025 ENOG4108VZI ErfK ybiS ycfS ynhG family protein GNE09_10040 ENOG4105D9U N-acetyltransferase GNE09_10045 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GNE09_10060 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic GNE09_10090 ENOG4105EJQ L-serine dehydratase GNE09_10095 ENOG4105II7 pyrroline-5-carboxylate reductase GNE09_10100 ENOG41069FQ Metallo-beta-lactamase superfamily GNE09_10105 ENOG4108IXY short-chain dehydrogenase reductase GNE09_10120 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) GNE09_10135 ENOG4105DBV ornithine carbamoyltransferase GNE09_10160 ENOG4105CGH 5'-nucleotidase GNE09_10165 ENOG4105DFD Na H antiporter GNE09_10175 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GNE09_10190 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GNE09_10195 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GNE09_10220 ENOG4108R6K riboflavin synthase, subunit alpha GNE09_10225 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GNE09_10245 ENOG4108YM7 Gcn5-related n-acetyltransferase GNE09_10250 ENOG4105ETE Transcriptional regulator (LacI family GNE09_10280 ENOG4105RHY Pfam:UPF0157 GNE09_10290 ENOG4105CPC Aldo Keto reductase GNE09_10310 ENOG4105MZ9 stage II sporulation protein m GNE09_10315 ENOG4105I3K Ferric uptake regulator, Fur family GNE09_10325 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GNE09_10350 ENOG4105D7N magnesium and cobalt transport protein CorA GNE09_10385 ENOG4105DVE abc transporter atp-binding protein GNE09_10390 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GNE09_10395 ENOG4105DZ1 carboxypeptidase GNE09_10400 ENOG41082AN stage II sporulation protein GNE09_10410 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GNE09_10415 ENOG4105C8J )-transporter GNE09_10435 ENOG41090VF Stage v sporulation protein ac GNE09_10440 ENOG4105CZ3 stage V sporulation protein ad GNE09_10450 ENOG4105G6R Stage v sporulation protein ae GNE09_10460 ENOG4105J7I hydrolase GNE09_10465 ENOG4105PTM secreted protein GNE09_10470 ENOG4107ZE5 PPIases accelerate the folding of proteins GNE09_10505 ENOG4105CE4 GlcNAc 6-P deacetylase GNE09_10515 ENOG4105FDP GntR family transcriptional regulator GNE09_10525 ENOG4105CID antiterminator GNE09_10540 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GNE09_10560 ENOG4105BZU Histidine kinase GNE09_10570 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GNE09_10585 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) GNE09_10610 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GNE09_10630 ENOG4105DTD Dehydrogenase GNE09_10635 ENOG4105K7K Transcriptional regulator GNE09_10665 ENOG4105CHU acetyl-coa acetyltransferase GNE09_10710 ENOG4105CG3 alpha amylase, catalytic region GNE09_10720 ENOG4107FKK extracellular solute-binding protein family 1 GNE09_10730 ENOG4105EG2 ABC transporter, permease GNE09_10735 ENOG4105FKQ transcriptional regulator GNE09_10740 ENOG4105CHM Aminotransferase GNE09_10750 ENOG4108HGU Histidine kinase GNE09_10805 ENOG4105UIN GNE09_10815 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GNE09_10830 ENOG4105K6S Short-chain dehydrogenase reductase Sdr GNE09_10835 ENOG4105EPM Diguanylate phosphodiesterase GNE09_10850 ENOG4107IN1 Protein of unknown function (DUF1797) GNE09_10855 ENOG4108XRC Protein of unknown function (DUF458) GNE09_10890 ENOG4107ZYR domain protein GNE09_10895 ENOG4105CN5 Metallo-Beta-Lactamase GNE09_10905 ENOG4108X4Q Hydrolase GNE09_10910 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GNE09_10925 ENOG4105CPP Dehydrogenase, E1 component GNE09_10995 ENOG4105ECY inositol monophosphatase GNE09_11005 ENOG4105CI3 gtp-binding protein typa GNE09_11030 ENOG4108IAB Phoh family GNE09_11045 ENOG4105CNI cell division protein FtsW GNE09_11050 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) GNE09_11100 ENOG4106UY4 Inherit from COG: Scp-like extracellular GNE09_11115 ENOG4107TB6 phosphoglycerate mutase GNE09_11140 ENOG4106H78 methyltransferase GNE09_11150 ENOG4105H20 Sporulation integral membrane protein YlbJ GNE09_11155 ENOG4105D78 K07001 NTE family protein GNE09_11160 ENOG41063PX domain protein GNE09_11170 ENOG4105KNH Nucleic acid-binding protein GNE09_11210 ENOG4105CJN penicillin-binding protein GNE09_11220 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GNE09_11235 ENOG4105CNI cell division protein FtsW GNE09_11240 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GNE09_11245 ENOG4105D4A Cell wall formation (By similarity) GNE09_11255 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GNE09_11260 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GNE09_11270 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GNE09_11280 ENOG4105WR5 sporulation protein, YlmC YmxH family GNE09_11285 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GNE09_11290 ENOG4105DFA alanine racemase domain protein GNE09_11300 ENOG41067XK integral membrane protein GNE09_11305 ENOG4105DBK s4 domain protein GNE09_11330 ENOG4105C34 Pseudouridine synthase GNE09_11415 ENOG4105F23 Fibronectin-binding protein GNE09_11425 ENOG4105DSJ YicC domain protein GNE09_11445 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase GNE09_11450 ENOG4105C25 Primosomal protein n' GNE09_11465 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GNE09_11475 ENOG4108ZF3 Phosphatase GNE09_11480 ENOG4105D9P serine threonine protein kinase GNE09_11485 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GNE09_11490 ENOG4105DJV ribulose-phosphate 3-epimerase GNE09_11495 ENOG4105FJ0 thiamine GNE09_11510 ENOG4108ZAA Alkaline-shock protein GNE09_11515 ENOG4105DP4 dak2 domain fusion protein ylov GNE09_11535 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GNE09_11540 ENOG4105CHR reductase GNE09_11555 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) GNE09_11560 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GNE09_11580 ENOG4105VB6 UPF0109 protein GNE09_11605 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) GNE09_11620 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha GNE09_11625 ENOG4105C79 DNA protecting protein DprA GNE09_11630 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GNE09_11670 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GNE09_11680 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GNE09_11685 ENOG4105KNE Phosphatidate cytidylyltransferase GNE09_11690 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GNE09_11695 ENOG4105DZP Membrane-associated zinc metalloprotease GNE09_11705 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) GNE09_11715 ENOG4105CHV Transcription elongation factor NusA GNE09_11720 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination GNE09_11725 ENOG4105VHM ribosomal protein GNE09_11735 ENOG4105W7A Protein of unknown function (DUF503) GNE09_11750 ENOG4105DTN riboflavin biosynthesis protein ribF GNE09_11770 ENOG4105C1V Peptidase, M16 GNE09_11780 ENOG4105E35 Dipicolinate synthase subunit A GNE09_11785 ENOG4108S0H Dipicolinic acid synthetase, b subunit GNE09_11790 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GNE09_11800 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GNE09_11810 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit GNE09_11820 ENOG4105CNU cell division protein FtsK GNE09_11825 ENOG4105FDP GntR family transcriptional regulator GNE09_11835 ENOG4108JQ9 ABC transporter GNE09_11840 ENOG4105UIB (ABC) transporter GNE09_11860 ENOG4108RKS Short-chain dehydrogenase reductase Sdr GNE09_11865 ENOG4105XZV Protein of unknown function (DUF3243) GNE09_11880 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase GNE09_11900 ENOG4105D48 metallophosphoesterase GNE09_11905 ENOG4105MCT stage V sporulation protein S GNE09_11910 ENOG4108IGT Dipeptidase GNE09_11915 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein GNE09_11920 ENOG4105DQU oxidoreductase, subunit beta GNE09_11955 ENOG410890F Dynamin family GNE09_11970 ENOG4105F0V Cell wall hydrolase GNE09_11980 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C GNE09_11985 ENOG4105C8Q Methyl-accepting chemotaxis GNE09_12010 ENOG41067MG lrgb family GNE09_12075 ENOG4105D03 DNA-3-methyladenine glycosylase II GNE09_12080 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GNE09_12090 ENOG4105CGK Exodeoxyribonuclease III GNE09_12110 ENOG4105E0A ABC, transporter GNE09_12115 ENOG4105NIV Esterase GNE09_12135 ENOG4105VPX protein, conserved in bacteria GNE09_12140 ENOG410681U heavy metal transport detoxification protein GNE09_12145 ENOG4105C59 p-type ATPase GNE09_12155 ENOG4105K70 DNA-binding protein GNE09_12160 ENOG4105TMB Formate nitrite transporter GNE09_12180 ENOG4105C85 amino acid GNE09_12190 ENOG4108SJC Membrane GNE09_12195 ENOG4107QW4 alcohol dehydrogenase GNE09_12200 ENOG4105E98 transcriptional regulator DeoR family GNE09_12205 ENOG4105DE4 1-phosphofructokinase GNE09_12210 ENOG4105DM4 PTS System GNE09_12215 ENOG41069ER domain protein GNE09_12245 ENOG4106F1P AAA ATPase, central domain protein GNE09_12250 ENOG4105EN6 Membrane GNE09_12255 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GNE09_12260 ENOG4105CXI aluminum resistance protein GNE09_12265 ENOG4105KV4 Transcriptional regulator GNE09_12270 ENOG4105C5F glutamine synthetase GNE09_12275 ENOG4105K7K Transcriptional regulator GNE09_12295 ENOG4108SVB resolvase GNE09_12305 ENOG4105CGH 5'-nucleotidase GNE09_12345 ENOG4105BZ1 (ABC) transporter GNE09_12350 ENOG4105BZ1 (ABC) transporter GNE09_12390 ENOG41067MG lrgb family GNE09_12395 ENOG4105VAW lrga family GNE09_12400 ENOG4107RSM transcriptional regulator GNE09_12420 ENOG4105CJ1 ABC, transporter GNE09_12430 ENOG4105CH2 amidohydrolase GNE09_12440 ENOG4107QIV Cytochrome c biogenesis protein GNE09_12495 ENOG4108903 Formimidoylglutamase GNE09_12500 ENOG4108VJ1 Transcriptional regulator (CarD family GNE09_12505 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GNE09_12510 ENOG4105CBC glutamate synthase GNE09_12520 ENOG4105CK7 Sodium proline symporter GNE09_12525 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase GNE09_12530 ENOG4105FBA Phospholipase Carboxylesterase GNE09_12535 ENOG4105BZU Histidine kinase GNE09_12545 ENOG4107AYK membrAne GNE09_12585 ENOG4105CEY Amp-dependent synthetase and ligase GNE09_12590 ENOG4107ZYJ bioY protein GNE09_12595 ENOG4107F3J Amp-dependent synthetase and ligase GNE09_12615 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GNE09_12625 ENOG4105E5W Transporter GNE09_12655 ENOG4108I0Z Aconitate hydratase GNE09_12670 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GNE09_12675 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) GNE09_12700 ENOG4105W8X HesB YadR YfhF-family protein GNE09_12705 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GNE09_12710 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase GNE09_12720 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GNE09_12725 ENOG4105C0H protease GNE09_12730 ENOG4105K4P CoA-binding domain protein GNE09_12735 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GNE09_12745 ENOG4105D9R oxidoreductase GNE09_12765 ENOG4105CIG ABC transporter GNE09_12775 ENOG4105EMN RNA polymerase sigma factor GNE09_12785 ENOG4108KGH TRANSCRIPTIONal GNE09_12790 ENOG4107QJT sodium dicarboxylate symporter GNE09_12860 ENOG4105E1K spore germination protein GNE09_12865 ENOG4108JB9 formate dehydrogenase GNE09_12875 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) GNE09_12880 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GNE09_12890 ENOG4105TMB Formate nitrite transporter GNE09_12895 ENOG4105D06 uba thif-type nad fad binding protein GNE09_12905 ENOG4108ZAF Molybdopterin GNE09_12915 ENOG4105D1F ATP-binding protein GNE09_12930 ENOG410696E Membrane GNE09_12935 ENOG4105FR1 rard protein GNE09_12945 ENOG4105EWU Squalene--hopene cyclase GNE09_12955 ENOG4105CHR reductase GNE09_12960 ENOG4105C26 Dehydrogenase GNE09_12970 ENOG4108IA2 Sodium pantothenate symporter GNE09_12985 ENOG4106IQC argininosuccinate lyase GNE09_12995 ENOG410904N short-chain dehydrogenase reductase GNE09_13015 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GNE09_13035 ENOG4105VEQ Cold shock protein GNE09_13050 ENOG4108R1P GNE09_13060 ENOG41073R8 VanW family GNE09_13065 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase GNE09_13075 ENOG4105KT7 mgtC SapB transporter GNE09_13085 ENOG4105BZU Histidine kinase GNE09_13105 ENOG4107DUR UPF0457 protein GNE09_13110 ENOG4108VXD carboxy-peptidase GNE09_13120 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity GNE09_13125 ENOG41067SE Tetr family transcriptional regulator GNE09_13130 ENOG4105C5H ABC transporter GNE09_13135 ENOG4105BZU Histidine kinase GNE09_13180 ENOG4105FAW cDP-glucose 4,6-dehydratase GNE09_13195 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase GNE09_13215 ENOG4105E1K spore germination protein GNE09_13225 ENOG4108M1A Chitin-binding protein GNE09_13230 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C GNE09_13255 ENOG4105C5E polysaccharide biosynthesis protein GNE09_13260 ENOG4105C1B dTDP-glucose 4-6-dehydratase GNE09_13265 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GNE09_13285 ENOG4105D2T synthase GNE09_13310 ENOG4105CEP NADH dehydrogenase GNE09_13330 ENOG4105CQB FAD linked oxidase domain protein GNE09_13335 ENOG4105C09 Bile acid GNE09_13355 ENOG4105CIS alcohol dehydrogenase GNE09_13360 ENOG41082BM Transcriptional regulator, arsr family GNE09_13370 ENOG4107VXM glycerophosphoryl diester phosphodiesterase GNE09_13385 ENOG4105E5T Major Facilitator Superfamily GNE09_13395 ENOG4108A04 Beta-lactamase GNE09_13425 ENOG4105DWY Agmatine deiminase GNE09_13430 ENOG4105DPN Oligoendopeptidase f GNE09_13435 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase GNE09_13440 ENOG4105E5K Alpha-amylase GNE09_13470 ENOG4107V2S Transcriptional regulator GNE09_13480 ENOG4107CUJ Protein of unknown function (DUF2690) GNE09_13500 ENOG4105NX3 Membrane GNE09_13505 ENOG4105DQ5 transport system permease protein GNE09_13510 ENOG4105EHG Permease protein GNE09_13515 ENOG4108MES Periplasmic binding protein GNE09_13530 ENOG4107R3E Citrate transporter GNE09_13540 ENOG4108TN2 lmbE family GNE09_13575 ENOG4105CIS alcohol dehydrogenase GNE09_13610 ENOG4105H3G oxidoreductase GNE09_13640 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) GNE09_13695 ENOG4108ZJ4 polysaccharide deacetylase GNE09_13710 ENOG4107SCK Monooxygenase GNE09_13715 ENOG4105KVH Transcriptional regulator GNE09_13735 ENOG4105JAB phenazine biosynthesis protein, phzf family GNE09_13780 ENOG4105D9R oxidoreductase GNE09_13785 ENOG4108TZY GntR Family Transcriptional Regulator GNE09_13815 ENOG4105C44 Serine transporter GNE09_13860 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) GNE09_13865 ENOG4105XDF Protein of unknown function (DUF1272) GNE09_13870 ENOG4105DDN Pentapeptide repeat-containing protein GNE09_13895 ENOG4105C37 (CBS) domain GNE09_13925 ENOG4105EV4 Multidrug resistance protein mdtH GNE09_13935 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) GNE09_13970 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GNE09_13975 ENOG4105C31 Tryptophanyl-tRNA synthetase GNE09_13985 ENOG4106UW1 Major Facilitator superfamily GNE09_13990 ENOG4105DKQ ROK family GNE09_13995 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase GNE09_14060 ENOG4108PSK reductase GNE09_14090 ENOG4108RCM Nitroreductase GNE09_14095 ENOG4105KVH Transcriptional regulator GNE09_14115 ENOG4108Z66 YbaK ebsC protein GNE09_14120 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) GNE09_14130 ENOG4108K8S endonuclease I GNE09_14190 ENOG4105DYS nad(p)h dehydrogenase (quinone) GNE09_14200 ENOG4105CRW Short chain fatty acid transporter GNE09_14215 ENOG4105CZM Major Facilitator GNE09_14220 ENOG4107MII Sugar-specific transcriptional regulator TrmB GNE09_14245 ENOG4105PNM synthesis protein GNE09_14250 ENOG4108VXD carboxy-peptidase GNE09_14450 ENOG4108IG5 Transcriptional regulator GNE09_14455 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase GNE09_14475 ENOG410874W AraC family transcriptional regulator GNE09_14480 ENOG41082W1 Cupin 2, conserved barrel domain protein GNE09_14495 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GNE09_14500 ENOG4108JQ1 Dehydrogenase GNE09_14525 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) GNE09_14535 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 GNE09_14540 ENOG4108U05 Transcriptional regulator GNE09_14555 ENOG4105BZU Histidine kinase GNE09_14560 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) GNE09_14580 ENOG4105JQZ Methyltransferase GNE09_14590 ENOG4105E0Y RtcB Protein GNE09_14600 ENOG4105K6H D-cysteine desulfhydrase GNE09_14620 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GNE09_14660 ENOG4105DNP FAD linked oxidase domain protein GNE09_14695 ENOG41062D9 Histidine kinase GNE09_14700 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GNE09_14740 ENOG4108YXU transcriptional regulator AsnC family GNE09_14745 ENOG4105CHR reductase GNE09_14750 ENOG4108IG5 Transcriptional regulator GNE09_14755 ENOG4107P5I polyketide synthase GNE09_14765 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) GNE09_14780 ENOG41085FC arsR family transcriptional regulator GNE09_14785 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase GNE09_14790 ENOG4105D6J arsenicaL-resistance protein GNE09_14815 ENOG4105DIK (ABC) transporter GNE09_14820 ENOG4105CC5 ABC transporter GNE09_14825 ENOG4105DSE periplasmic solute binding protein GNE09_14830 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GNE09_14840 ENOG4107VMI polysaccharide deacetylase GNE09_14845 ENOG4105E1K spore germination protein GNE09_14860 ENOG4105GPN Uncharacterized conserved protein (DUF2294) GNE09_14865 ENOG4108TWJ NADH dehydrogenase subunit 5 GNE09_14880 ENOG4105CVP deoxyribo-dipyrimidine photolyase GNE09_14885 ENOG4108606 TspO/MBR family GNE09_14900 ENOG4105F6J Alpha beta hydrolase fold GNE09_14925 ENOG41090MY MarR family Transcriptional regulator GNE09_14950 ENOG4105CHJ isochorismatase hydrolase GNE09_14960 ENOG4105CGH 5'-nucleotidase GNE09_14975 ENOG4106A3M Cytochrome p-450 GNE09_15010 ENOG4108Q8B Spore germination protein GNE09_15020 ENOG4105II7 pyrroline-5-carboxylate reductase GNE09_15025 ENOG4105CUB amino acid GNE09_15035 ENOG4105YWU small acid-soluble spore protein GNE09_15070 ENOG4105BZU Histidine kinase GNE09_15100 ENOG4108IMY Transcriptional regulator GNE09_15105 ENOG4105HDK L-asparaginase GNE09_15110 ENOG4108IJ0 Aspartate ammonia-lyase GNE09_15120 ENOG4105E2A Dehydrogenase GNE09_15145 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GNE09_15185 ENOG4105DWD nucleoside recognition domain protein GNE09_15200 ENOG4105FDT acyl-CoA dehydrogenase GNE09_15210 ENOG4108ZHR arsR family transcriptional regulator GNE09_15215 ENOG4106N3A copper homeostasis protein cutc GNE09_15225 ENOG4107258 Transcriptional regulator GNE09_15230 ENOG4105P4J Allophanate hydrolase, subunit 1 GNE09_15260 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GNE09_15265 ENOG4107RF6 penicillin-binding protein GNE09_15290 ENOG4105BZU Histidine kinase GNE09_15300 ENOG4108VJ1 Transcriptional regulator (CarD family GNE09_15350 ENOG4108IQI permease GNE09_15360 ENOG410635A Membrane GNE09_15405 ENOG4108PCN EamA-like transporter family GNE09_15410 ENOG4105E09 nadh pyrophosphatase GNE09_15420 ENOG4108XET gCN5-related N-acetyltransferase GNE09_15445 ENOG4105WEC Molybdate metabolism regulator GNE09_15450 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GNE09_15465 ENOG4105FS7 Transcriptional regulator GNE09_15470 ENOG4108TVJ Nitroreductase GNE09_15490 ENOG4108IBT Inherit from COG: transposase GNE09_15510 ENOG4106BHF GNE09_15515 ENOG41090AA GNE09_15565 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GNE09_15600 ENOG4105CH6 catalase GNE09_15605 ENOG4105C8Y Acetylornithine aminotransferase GNE09_15625 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GNE09_15650 ENOG4105KNA -acetyltransferase GNE09_15670 ENOG4105VMP Transcriptional regulator GNE09_15685 ENOG4107RBI VanW family GNE09_15695 ENOG4105ECK Fatty Acid Desaturase GNE09_15715 ENOG4107258 Transcriptional regulator GNE09_15725 ENOG4105II7 pyrroline-5-carboxylate reductase GNE09_15745 ENOG4105YVS arsR family transcriptional regulator GNE09_15755 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) GNE09_15775 ENOG41061GT Aldolase GNE09_15785 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) GNE09_15790 ENOG4105DKT Transcriptional regulator GNE09_15795 ENOG4105C2J ABC transporter GNE09_15800 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane GNE09_15810 ENOG4105D4B ABC, transporter GNE09_15895 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GNE09_15920 ENOG41082JN Transcriptional regulator GNE09_15930 ENOG4105C5H ABC transporter GNE09_15935 ENOG4105E0M Sulfatase GNE09_15940 ENOG4108ZCF integral membrane protein GNE09_15960 ENOG4107VMI polysaccharide deacetylase GNE09_15980 ENOG4105C6T cysteine synthase GNE09_15985 ENOG4107VC0 DNA alkylation repair enzyme GNE09_16020 ENOG4108AQF aminoglycoside N(3)-acetyltransferase GNE09_16045 ENOG4105D7T ABC transporter GNE09_16050 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein GNE09_16055 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GNE09_16070 ENOG4105C02 permease GNE09_16115 ENOG4105DVE abc transporter atp-binding protein GNE09_16130 ENOG4108ZMI UPF0477 protein GNE09_16145 ENOG4105CHM Aminotransferase GNE09_16180 ENOG41089UC methyltransferase, type 11 GNE09_16195 ENOG4107BMA Transglycosylase associated protein GNE09_16220 ENOG4106K7D Major facilitator family transporter GNE09_16225 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) GNE09_16285 ENOG4105EPR degv family GNE09_16290 ENOG4105DPN Oligoendopeptidase f GNE09_16315 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GNE09_16325 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GNE09_16330 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) GNE09_16380 ENOG4105DTQ mandelate racemase muconate lactonizing GNE09_16395 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD GNE09_16405 ENOG4107T5V SNARE associated Golgi GNE09_16410 ENOG4105DCI Phosphohydrolase GNE09_16415 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GNE09_16445 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein GNE09_16455 ENOG41080HI glycine oxidase GNE09_16460 ENOG4105CTU Proline racemase GNE09_16470 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GNE09_16475 ENOG4105C26 Dehydrogenase GNE09_16480 ENOG4105BZG amino acid carrier protein GNE09_16500 ENOG4108M1A Chitin-binding protein GNE09_16550 ENOG4105C9U ATP-dependent DNA helicase RecQ GNE09_16565 ENOG4105EEM helicase GNE09_16570 ENOG4105KEG ribosomal-protein-alanine acetyltransferase GNE09_16595 ENOG4108Z7F N-acetyltransferase GNE09_16620 ENOG4105MSB protein, conserved in bacteria GNE09_16625 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GNE09_16640 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GNE09_16655 ENOG4108M1A Chitin-binding protein GNE09_16670 ENOG41082BV acetyltransferase GNE09_16675 ENOG4105E66 phosphoriboisomerase A GNE09_16700 ENOG4108IJ7 Glycine betaine GNE09_16705 ENOG4107SQ8 Glycine betaine GNE09_16735 ENOG4105E1F short-chain dehydrogenase reductase GNE09_16745 ENOG4107RUY (E1 component), alpha subunit GNE09_16755 ENOG4107QKR Dehydrogenase GNE09_16775 ENOG41062ES Transcriptional regulator GNE09_16790 ENOG4105E98 transcriptional regulator DeoR family GNE09_16805 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family GNE09_16825 ENOG4107Z3H Transcriptional regulator, TetR family GNE09_16830 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) GNE09_16835 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) GNE09_16865 ENOG4105MSI germination protein ypeb GNE09_16915 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GNE09_16920 ENOG4105FDR Membrane GNE09_16930 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) GNE09_16945 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic GNE09_16955 ENOG4108IUM Glycogen debranching enzyme GNE09_16970 ENOG4105DY8 decarboxylase GNE09_16985 ENOG4107WD8 ABC transporter, permease GNE09_17005 ENOG4105BZU Histidine kinase GNE09_17010 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GNE09_17015 ENOG4105U0R haloacid dehalogenase-like hydrolase GNE09_17040 ENOG4107VFR oxidoreductase GNE09_17060 ENOG41087PP glycosyltransferase MGT family GNE09_17095 ENOG4105PKS Excinuclease abc c subunit domain protein GNE09_17105 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GNE09_17120 ENOG4108YYS metal-dependent hydrolase (By similarity) GNE09_17130 ENOG4105KWG Pfam:DUF1696 GNE09_17135 ENOG4108NRW Phospholipase, patatin family GNE09_17185 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GNE09_17200 ENOG4105FCD Major Facilitator GNE09_17215 ENOG4105M6F mutator MutT protein GNE09_17220 ENOG4105EGD dinuclear metal center protein, YbgI family GNE09_17240 ENOG4107Y9U Membrane GNE09_17265 ENOG4107VXM glycerophosphoryl diester phosphodiesterase GNE09_17325 ENOG4105CJN penicillin-binding protein GNE09_17330 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GNE09_17335 ENOG4105CB2 alcohol dehydrogenase GNE09_17445 ENOG4108JJB ABC transporter GNE09_17645 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GNE09_17655 ENOG4105CAR Terminase, large subunit GNE09_17775 ENOG4108IMY Transcriptional regulator GNE09_17785 ENOG4105VTR Integrase GNE09_17815 ENOG4105ETU transcriptional activator (TenA GNE09_17820 ENOG4105CPF Cell wall formation (By similarity) GNE09_17830 ENOG4105D6E homoserine dehydrogenase GNE09_17875 ENOG4105CPC Aldo Keto reductase GNE09_17880 ENOG4106NZI LysR family Transcriptional regulator GNE09_17905 ENOG4105DK7 lysyl-tRNA synthetase GNE09_17910 ENOG4105DK7 lysyl-tRNA synthetase GNE09_17920 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein GNE09_17930 ENOG4108V4B ThiJ pfpI GNE09_17945 ENOG4105CPQ Dehydrogenase GNE09_18010 ENOG4105KVH Transcriptional regulator GNE09_18015 ENOG4105CHR reductase GNE09_18025 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GNE09_18075 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) GNE09_18090 ENOG4105T9C HD domain GNE09_18145 ENOG4107QX3 carboxylase GNE09_18150 ENOG4105E39 Enoyl-CoA hydratase GNE09_18160 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit GNE09_18165 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GNE09_18170 ENOG4105C1G acyl-Coa dehydrogenase GNE09_18185 ENOG4107Z3H Transcriptional regulator, TetR family GNE09_18205 ENOG4105DIN metallophosphoesterase GNE09_18220 ENOG4107RF6 penicillin-binding protein GNE09_18265 ENOG4107VMI polysaccharide deacetylase GNE09_18280 ENOG4108IMY Transcriptional regulator GNE09_18325 ENOG4105IIU Aminopeptidase GNE09_18335 ENOG4105FJR Lmbe family GNE09_18355 ENOG4108IAJ Nad-dependent epimerase dehydratase GNE09_18360 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GNE09_18365 ENOG4107QQG Dehydrogenase GNE09_18370 ENOG4108W0I acetyltransferase GNE09_18430 ENOG4105CHR reductase GNE09_18440 ENOG4105W8Z 4'-phosphopantetheinyl transferase GNE09_18485 ENOG4105EJ9 Membrane GNE09_18495 ENOG4105KRN Transcriptional regulator, abrb family GNE09_18520 ENOG4105CIN aminoacyl-histidine dipeptidase GNE09_18560 ENOG4107RA9 decarboxylase GNE09_18565 ENOG4108I0C methyltransferase GNE09_18575 ENOG41088CC tellurite resistance protein tehB GNE09_18580 ENOG4105C1J atp-dependent rna helicase GNE09_18590 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GNE09_18610 ENOG4105C7B Threonine dehydratase GNE09_18615 ENOG4107STF Involved in phosphonate degradation (By similarity) GNE09_18620 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GNE09_18625 ENOG4105RD7 BadF BadG BcrA BcrD GNE09_18650 ENOG4105F32 YngK protein GNE09_18670 ENOG4108KPJ rna polymerase sigma factor GNE09_18675 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) GNE09_18705 ENOG4108JCI Transcriptional regulator GNE09_18730 ENOG4105BZ1 (ABC) transporter GNE09_18735 ENOG4105BZ1 (ABC) transporter GNE09_18750 ENOG4108RPX mosc domain containing protein GNE09_18755 ENOG4105DND Transcriptional regulator GNE09_18775 ENOG4107V2S Transcriptional regulator GNE09_18805 ENOG41068WN GNE09_18815 ENOG4105C1Q protoporphyrinogen oxidase GNE09_18840 ENOG4105WCN acetyltransferase GNE09_18865 ENOG4105EYF MMPL domain protein GNE09_18875 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GNE09_18900 ENOG41081I9 integral membrane protein GNE09_18935 ENOG4105C19 ABC transporter GNE09_18940 ENOG4105C22 threonyL-tRNA synthetase GNE09_18945 ENOG4105FE9 pseudouridine synthase GNE09_18965 ENOG4105BZG amino acid carrier protein GNE09_18985 ENOG4105K70 DNA-binding protein GNE09_19000 ENOG4105C0R drug resistance transporter emrb qaca subfamily GNE09_19005 ENOG4105WQT MbtH domain protein GNE09_19010 ENOG4105CEY Amp-dependent synthetase and ligase GNE09_19015 ENOG4105WQI isochorismatase GNE09_19020 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase GNE09_19025 ENOG4105E4F Isochorismate synthase GNE09_19030 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase GNE09_19035 ENOG4105FCD Major Facilitator GNE09_19050 ENOG4105EYH Exonuclease GNE09_19055 ENOG4107RFY SbcCD D subunit GNE09_19075 ENOG4105N14 lysine exporter protein LysE YggA GNE09_19085 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GNE09_19090 ENOG4105C1G acyl-Coa dehydrogenase GNE09_19095 ENOG4105CR4 methylisocitrate lyase GNE09_19100 ENOG4105DXD 2-methylcitrate dehydratase GNE09_19110 ENOG4105W8X HesB YadR YfhF-family protein GNE09_19115 ENOG4105CZM Major Facilitator GNE09_19180 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GNE09_19235 ENOG4105KNA -acetyltransferase GNE09_19240 ENOG4105SZ6 Thioredoxin GNE09_19250 ENOG410841Q phosphoesterase PA-phosphatase related protein GNE09_19295 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein GNE09_19305 ENOG4108TSC N-acetyltransferase GNE09_19310 ENOG4107S4Y M20 DapE family protein YgeY GNE09_19325 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GNE09_19350 ENOG4105C37 (CBS) domain GNE09_19390 ENOG4108IJ8 ABC transporter GNE09_19430 ENOG4105C6Z Gluconate GNE09_19435 ENOG4105CMG Carbohydrate kinase GNE09_19455 ENOG4107ZY0 Phenazine biosynthesis-like protein GNE09_19460 ENOG4106KNT transcriptional regulator GNE09_19465 ENOG4105WH1 Two component transcriptional regulator luxr family GNE09_19475 ENOG4105D8X mechanosensitive ion channel GNE09_19500 ENOG4105F0I Aminotransferase GNE09_19505 ENOG4108MES Periplasmic binding protein GNE09_19510 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GNE09_19525 ENOG4105CAQ asparagine synthetase GNE09_19530 ENOG4107Y70 Heat shock protein GNE09_19535 ENOG4108KF3 Electron transport protein SCO1 SenC GNE09_19545 ENOG4108RCR degv family GNE09_19565 ENOG4108UT2 hemolysin iii GNE09_19570 ENOG4105E9Q Acyl-transferase GNE09_19580 ENOG4107RVG penicillin-binding protein GNE09_19610 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 GNE09_19635 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase GNE09_19650 ENOG4105KD7 acetyltransferase GNE09_19670 ENOG4105CY2 Citrate transporter GNE09_19695 ENOG4105C8J )-transporter GNE09_19700 ENOG4105C5S asparaginyl-tRNA synthetase GNE09_19715 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GNE09_19740 ENOG4105C75 arginyL-tRNA synthetase GNE09_19745 ENOG4107YX5 Pfam:DUF548 GNE09_19770 ENOG4108UUM single-stranded DNA-binding protein GNE09_19785 ENOG4105C5H ABC transporter GNE09_19820 ENOG4105MCT stage V sporulation protein S GNE09_19855 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) GNE09_19860 ENOG4108IFG nitrite reductase, (NAD(P)H) GNE09_19865 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit GNE09_19870 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GNE09_19875 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein GNE09_19880 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein GNE09_19910 ENOG4108ZAF Molybdopterin GNE09_19915 ENOG4105CVM Molybdenum cofactor synthesis domain protein GNE09_19920 ENOG4105D06 uba thif-type nad fad binding protein GNE09_19925 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GNE09_19930 ENOG4107V6Q Cyclic nucleotide-binding domain GNE09_19940 ENOG4105R3A Nitrate reductase GNE09_19945 ENOG4108IUE nitrate reductase beta subunit GNE09_19955 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GNE09_19970 ENOG4108V06 Glutathione peroxidase GNE09_19980 ENOG4105CNW domain protein GNE09_19990 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) GNE09_20000 ENOG4105EMN RNA polymerase sigma factor GNE09_20005 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GNE09_20015 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily GNE09_20020 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) GNE09_20045 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GNE09_20070 ENOG4105KBJ sporulation protein ytfj GNE09_20080 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GNE09_20165 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) GNE09_20245 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) GNE09_20275 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GNE09_20310 ENOG4108JYZ YitT family GNE09_20315 ENOG41087PP glycosyltransferase MGT family GNE09_20335 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GNE09_20350 ENOG41082F9 transcriptional regulator GNE09_20355 ENOG4108X4Q Hydrolase GNE09_20365 ENOG4108ZRV stage ii sporulation protein p GNE09_20395 ENOG4108VXD carboxy-peptidase GNE09_20405 ENOG4108ZRV stage ii sporulation protein p GNE09_20425 ENOG4108Z7R Chaperone CsaA GNE09_20455 ENOG4105C37 (CBS) domain GNE09_20460 ENOG4105SXS Protein of unknown function (DUF456) GNE09_20490 ENOG4108S4H thioesterase Superfamily protein GNE09_20515 ENOG4107T5V SNARE associated Golgi GNE09_20535 ENOG4105CVJ phosphoglycerate mutase GNE09_20560 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GNE09_20570 ENOG4105K4T epimerase GNE09_20575 ENOG4105DSE periplasmic solute binding protein GNE09_20585 ENOG4105CKI cobalamin synthesis protein GNE09_20590 ENOG4107QM2 Aldo Keto reductase GNE09_20595 ENOG4105VMI -acetyltransferase GNE09_20610 ENOG4105DEN Luciferase family GNE09_20625 ENOG4108WPJ Ferritin-like domain GNE09_20630 ENOG4108K88 Membrane GNE09_20645 ENOG4105C8Q Methyl-accepting chemotaxis GNE09_20675 ENOG4105CPC Aldo Keto reductase GNE09_20680 ENOG4105YVS arsR family transcriptional regulator GNE09_20690 ENOG4105KRN Transcriptional regulator, abrb family GNE09_20740 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GNE09_20745 ENOG4108ZUB Lysine exporter protein (Lyse ygga) GNE09_20755 ENOG4105YWU small acid-soluble spore protein GNE09_20760 ENOG4108WBH protein TIM barrel GNE09_20775 ENOG4105CEY Amp-dependent synthetase and ligase GNE09_20780 ENOG4105DUU IucA IucC family protein GNE09_20795 ENOG4105KT7 mgtC SapB transporter GNE09_20810 ENOG4108KGH TRANSCRIPTIONal GNE09_20835 ENOG4105D6E homoserine dehydrogenase GNE09_20855 ENOG4108ZJ4 polysaccharide deacetylase GNE09_20860 ENOG41075D4 Aminoglycoside 6-adenylyltransferase GNE09_20880 ENOG4105BZU Histidine kinase GNE09_20885 ENOG4105EFI regulatoR GNE09_20890 ENOG4105BZ1 (ABC) transporter GNE09_20945 ENOG4108UT6 Transferase hexapeptide repeat containing protein GNE09_20955 ENOG4105K64 Glycosyl transferase, family 2 GNE09_20965 ENOG4108JJ8 (ABC) transporter GNE09_20970 ENOG4108JJ9 ABC, transporter GNE09_20975 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GNE09_20980 ENOG4105C4M (Ubiquinol oxidase) subunit I GNE09_21015 ENOG4107XZA Glycosyl transferase family 2 GNE09_21030 ENOG4105CJ1 ABC, transporter GNE09_21035 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GNE09_21040 ENOG4105CEY Amp-dependent synthetase and ligase GNE09_21060 ENOG4105FAW cDP-glucose 4,6-dehydratase GNE09_21065 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase GNE09_21080 ENOG4105SKE transcriptional Regulator LysR family GNE09_21090 ENOG4105C32 Amino acid ABC transporter (Permease) GNE09_21095 ENOG4108IV0 ABC, transporter GNE09_21100 ENOG4105C0Z ABC transporter GNE09_21110 ENOG4105CKI cobalamin synthesis protein GNE09_21120 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GNE09_21125 ENOG4106F5Q Membrane GNE09_21130 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GNE09_21135 ENOG4108TVJ Nitroreductase GNE09_21140 ENOG4107ZXU DSBA oxidoreductase GNE09_21145 ENOG4108Z40 Transcriptional regulator GNE09_21150 ENOG4105GZI Transcriptional regulator GNE09_21155 ENOG4107RT3 EamA-like transporter family GNE09_21160 ENOG4105KTB nuclear export factor GLE1 GNE09_21165 ENOG4108T5E Copper resistance protein GNE09_21205 ENOG4107R16 Multicopper oxidase GNE09_21215 ENOG4107RAQ aminopeptidase GNE09_21245 ENOG4108IBT Inherit from COG: transposase GNE09_21260 ENOG4105KG3 cytidine deaminase GNE09_21265 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) GNE09_21270 ENOG4105D9N nucleoside GNE09_21280 ENOG4107RHR regulatoR GNE09_21300 ENOG410849A acetyltransferase, (GNAT) family GNE09_21335 ENOG4105C0X amino acid GNE09_21355 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) GNE09_21375 ENOG41068WN GNE09_21400 ENOG4105CYC Transferase GNE09_21405 ENOG4105DY9 regulatoR GNE09_21420 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b GNE09_21450 ENOG4105C7B Threonine dehydratase GNE09_21460 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GNE09_21475 ENOG4105CM2 brancheD-chain amino acid aminotransferase GNE09_21480 ENOG4105CHR reductase GNE09_21505 ENOG4105H67 Protein of unknown function (DUF421) GNE09_21510 ENOG4105X5K response regulator receiver protein GNE09_21520 ENOG4105C8J )-transporter GNE09_21540 ENOG4105C6T cysteine synthase GNE09_21550 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GNE09_21560 ENOG4105DXI Major Facilitator superfamily GNE09_21570 ENOG4105U3E Transcriptional regulator GNE09_21575 ENOG4105CSR polyphosphate kinase 2 GNE09_21590 ENOG4105FVX GNE09_21640 ENOG4105C6K Malic enzyme GNE09_21645 ENOG4108IJ0 Aspartate ammonia-lyase GNE09_21655 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GNE09_21675 ENOG4105CJ1 ABC, transporter GNE09_21710 ENOG4106BRA Membrane GNE09_21730 ENOG4107JM4 Tetratricopeptide repeat GNE09_21740 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GNE09_21745 ENOG4107QIV Cytochrome c biogenesis protein GNE09_21765 ENOG4105EC3 peptidase S51, dipeptidase E GNE09_21770 ENOG4107QJQ Mate efflux family protein GNE09_21790 ENOG4105C9Q fumarate hydratase class II GNE09_21800 ENOG4105VUF Transcriptional regulator GNE09_21805 ENOG4105DFD Na H antiporter GNE09_21820 ENOG4108PJD permease GNE09_21845 ENOG4105PGM cation diffusion facilitator family transporter GNE09_21865 ENOG4105CAQ asparagine synthetase GNE09_21875 ENOG4105K56 Transcriptional regulator GNE09_21885 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GNE09_21895 ENOG4105CVJ phosphoglycerate mutase GNE09_21935 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component GNE09_21945 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GNE09_21950 ENOG4105DUM transcriptional regulator, lysR family GNE09_21975 ENOG4107QZ7 Cellulose synthase catalytic subunit GNE09_21980 ENOG4105KAC Antibiotic biosynthesis monooxygenase GNE09_22010 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GNE09_22015 ENOG4105CPU Monooxygenase GNE09_22020 ENOG4105KTQ flagellar basal-body rod protein GNE09_22025 ENOG4105FZW flagellar biosynthesis regulator FlhF GNE09_22030 ENOG4105D7B Flagellar biosynthesis protein flha GNE09_22035 ENOG4105D00 flagellar biosynthetic protein flhB GNE09_22045 ENOG4105VS8 Flagellar biosynthetic protein fliq GNE09_22060 ENOG4105DD5 Flagellar motor switch protein GNE09_22065 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GNE09_22075 ENOG4105E4C Lytic transglycosylase catalytic GNE09_22080 ENOG4105I03 Flagellin GNE09_22085 ENOG4105I03 Flagellin GNE09_22095 ENOG4107R88 Chemotaxis protein (CheV) GNE09_22110 ENOG4105BZE flagellar hook protein, FlgE GNE09_22140 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GNE09_22145 ENOG4107U2N Flagellar M-ring protein GNE09_22150 ENOG41075Z6 flagellar hook-basal body complex protein fliE GNE09_22155 ENOG4108ZC9 flagellar basal-body rod protein flgc GNE09_22160 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GNE09_22180 ENOG4105DTJ flagellar hook-associated protein GNE09_22185 ENOG4105E1Q flagellar hook-associated protein GNE09_22205 ENOG4105BZU Histidine kinase GNE09_22220 ENOG4105DD5 Flagellar motor switch protein GNE09_22225 ENOG4105CBS Chea signal transduction histidine kinase GNE09_22230 ENOG4107YTP response regulator receiver protein GNE09_22235 ENOG4105ER2 Ompa motb domain protein GNE09_22240 ENOG4107R0U MotA TolQ exbB proton channel GNE09_22250 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GNE09_22285 ENOG41080C8 DUF218 domain GNE09_22290 ENOG4105H67 Protein of unknown function (DUF421) GNE09_22300 ENOG4108Z5V transcriptional regulator, merr family GNE09_22305 ENOG4105CN5 Metallo-Beta-Lactamase GNE09_22310 ENOG4107RWR Sodium hydrogen exchanger GNE09_22320 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GNE09_22385 ENOG41081VK Ribonuclease GNE09_22405 ENOG4108SZE gCN5-related N-acetyltransferase GNE09_22420 ENOG4105CPK Glycosyl transferase (Group 1 GNE09_22480 ENOG4106032 Glutathionylspermidine synthase GNE09_22505 ENOG4105KHC sulfurtransferase GNE09_22515 ENOG4108W0I acetyltransferase GNE09_22530 ENOG4105DHF Membrane GNE09_22535 ENOG4105C2W permease GNE09_22560 ENOG4105CTD carboxy-peptidase GNE09_22565 ENOG4105DVT helicase GNE09_22575 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) GNE09_22630 ENOG4105BZ4 penicillin-binding protein GNE09_22640 ENOG4105CSM endonuclease III GNE09_22660 ENOG4105YAC GNE09_22705 ENOG4105FJR Lmbe family GNE09_22720 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase GNE09_22725 ENOG4108JYZ YitT family GNE09_22760 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GNE09_22765 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) GNE09_22780 ENOG41068YB TPR repeat-containing protein GNE09_22795 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GNE09_22800 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GNE09_22805 ENOG4105EAH synthase GNE09_22815 ENOG4105XXQ heptaprenyl diphosphate synthase component I GNE09_22830 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) GNE09_22860 ENOG41065D1 GNE09_22865 ENOG4105S2F GNE09_22895 ENOG4107RB3 L-asparaginase GNE09_22900 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase GNE09_22925 ENOG4108S6Z Negative regulator of genetic competence GNE09_22930 ENOG4108XDN Transcriptional regulator GNE09_22935 ENOG4107RGJ metallophosphoesterase GNE09_22950 ENOG4105C9U ATP-dependent DNA helicase RecQ GNE09_22965 ENOG4108SAX Membrane GNE09_22980 ENOG4108WBT adenosyltransferase GNE09_22985 ENOG4105BZU Histidine kinase GNE09_22990 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GNE09_22995 ENOG4105CRE cytochrome C GNE09_23000 ENOG4107TWT Cytochrome c biogenesis protein GNE09_23005 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GNE09_23010 ENOG4105FE9 pseudouridine synthase GNE09_23020 ENOG4108JIC nucleoside recognition domain protein GNE09_23025 ENOG4105DZ1 carboxypeptidase GNE09_23075 ENOG4105I3N Conserved Protein GNE09_23080 ENOG4105BZU Histidine kinase GNE09_23095 ENOG4105BZ4 penicillin-binding protein GNE09_23100 ENOG4107GRR phosphate transport regulator GNE09_23105 ENOG4105CJ3 phosphate transporter GNE09_23150 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GNE09_23170 ENOG4105WH1 Two component transcriptional regulator luxr family GNE09_23175 ENOG4105ENE Histidine kinase GNE09_23195 ENOG4105DFD Na H antiporter GNE09_23215 ENOG4105C8J )-transporter GNE09_23220 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein GNE09_23225 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein GNE09_23230 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GNE09_23240 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) GNE09_23245 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) GNE09_23265 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GNE09_23275 ENOG4105E0M Sulfatase GNE09_23280 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase GNE09_23295 ENOG4107RVV histidinol phosphate phosphatase, hisj family GNE09_23330 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GNE09_23365 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GNE09_23370 ENOG4108ZP8 Acetolactate synthase small subunit GNE09_23375 ENOG4105C7K acetolactate synthase GNE09_23380 ENOG4105CM2 brancheD-chain amino acid aminotransferase GNE09_23400 ENOG4105KBJ sporulation protein ytfj GNE09_23405 ENOG41063Y9 GNE09_23410 ENOG4105CZN Potassium uptake protein GNE09_23440 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GNE09_23470 ENOG4105NQC Flavodoxin GNE09_23490 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein GNE09_23500 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD GNE09_23505 ENOG4105EA8 2-Nitropropane dioxygenase GNE09_23510 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GNE09_23550 ENOG4105CJ1 ABC, transporter GNE09_23560 ENOG4105CZV ABC transporter GNE09_23565 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family GNE09_23570 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GNE09_23575 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GNE09_23580 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) GNE09_23615 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) GNE09_23620 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase GNE09_23630 ENOG4105BZU Histidine kinase GNE09_23635 ENOG4106DF1 GNE09_23645 ENOG41090MY MarR family Transcriptional regulator GNE09_23650 ENOG4105BZU Histidine kinase GNE09_23660 ENOG4105PXI polysaccharide deacetylase GNE09_23670 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) GNE09_23680 ENOG4105E98 transcriptional regulator DeoR family GNE09_23700 ENOG4107RCV ABC transporter, permease GNE09_23705 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GNE09_23710 ENOG4105C4Y ABC transporter GNE09_23735 ENOG4105CHR reductase GNE09_23755 ENOG4108Z7G MaoC domain protein dehydratase GNE09_23760 ENOG410681C small acid-soluble spore protein GNE09_23765 ENOG4105CZN Potassium uptake protein GNE09_23770 ENOG4107TS3 membrane protein, TerC GNE09_23775 ENOG4108QTI )-transporter GNE09_23785 ENOG4106A3R peptidase GNE09_23805 ENOG4105JXH GntR family transcriptional regulator GNE09_23810 ENOG4105BZU Histidine kinase GNE09_23815 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GNE09_23830 ENOG4105CQB FAD linked oxidase domain protein GNE09_23835 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GNE09_23840 ENOG4105K4I Scp-like extracellular GNE09_23850 ENOG4108YBP pseudouridine synthase GNE09_23860 ENOG4105EYF MMPL domain protein GNE09_23865 ENOG410841Q phosphoesterase PA-phosphatase related protein GNE09_23870 ENOG4107RUE extracellular solute-binding protein family 1 GNE09_23875 ENOG4105D38 putrescine abc transporter GNE09_23880 ENOG4105F38 ABC transporter, permease GNE09_23890 ENOG4105C26 Dehydrogenase GNE09_23925 ENOG4105VFR signal peptidase GNE09_23930 ENOG4105DZ1 carboxypeptidase GNE09_23940 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) GNE09_23980 ENOG4105VZ8 Transcriptional regulator GNE09_23990 ENOG4105C7S Dehydrogenase GNE09_24090 ENOG4105DDQ anthranilate synthase GNE09_24095 ENOG4105CRQ synthase (Component I) GNE09_24100 ENOG4105CK7 Sodium proline symporter GNE09_24175 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase GNE09_24185 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase GNE09_24190 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) GNE09_24210 ENOG4107TVC Glycosyl transferase, family 2 GNE09_24230 ENOG4105K64 Glycosyl transferase, family 2 GNE09_24250 ENOG4105EMS pseudouridine synthase GNE09_24255 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GNE09_24270 ENOG4105MIX Adenylate cyclase GNE09_24275 ENOG4108Z18 K06886 hemoglobin GNE09_24285 ENOG4105DPN Oligoendopeptidase f GNE09_24295 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GNE09_24305 ENOG4108ZCF integral membrane protein GNE09_24325 ENOG4105UQX Mate efflux family protein GNE09_24330 ENOG4108JQ7 (ABC) transporter GNE09_24340 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GNE09_24345 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GNE09_24360 ENOG4105C31 Tryptophanyl-tRNA synthetase GNE09_24375 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GNE09_24380 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GNE09_24405 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GNE09_24415 ENOG4108KP7 hydrolase GNE09_24425 ENOG41073B9 GNE09_24430 ENOG4107AYK membrAne GNE09_24440 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GNE09_24475 ENOG4105QNR S1 RNA binding domain protein GNE09_24495 ENOG4105BZU Histidine kinase GNE09_24500 ENOG4105CH6 catalase GNE09_24505 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GNE09_24510 ENOG4105CAQ asparagine synthetase GNE09_24525 ENOG4105C8Y Acetylornithine aminotransferase GNE09_24535 ENOG4105ERH Fumarylacetoacetate hydrolase GNE09_24600 ENOG4105XVF Competence transcription factor GNE09_24615 ENOG4105VEQ Cold shock protein GNE09_24635 ENOG4107QP3 malate synthase g GNE09_24645 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) GNE09_24655 ENOG4105C8Q Methyl-accepting chemotaxis GNE09_24660 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 GNE09_24680 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GNE09_24695 ENOG41086D8 Transcriptional regulator GNE09_24700 ENOG4108AEY RNA polymerase sigma factor GNE09_24715 ENOG4107TVP HD domain protein GNE09_24720 ENOG4107RN3 metallophosphoesterase GNE09_24725 ENOG4105ENX hydrolase GNE09_24735 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) GNE09_24780 ENOG4105CEY Amp-dependent synthetase and ligase GNE09_24790 ENOG4105DF9 Lipoate-protein, ligase GNE09_24795 ENOG4108RQ5 Beta-lactamase domain-containing protein GNE09_24800 ENOG4106AXD GNE09_24830 ENOG4105ECB domain protein GNE09_24860 ENOG4105C1Q protoporphyrinogen oxidase GNE09_24875 ENOG4105BZ4 penicillin-binding protein GNE09_24880 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation GNE09_24890 ENOG410905X membrane-flanked domain protein GNE09_24930 ENOG4105CKV Membrane GNE09_24935 ENOG410905X membrane-flanked domain protein GNE09_24965 ENOG4105K59 histidine triad (HIT) protein GNE09_24990 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GNE09_24995 ENOG4105EEM helicase GNE09_25010 ENOG4105EMN RNA polymerase sigma factor GNE09_25025 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GNE09_25040 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator GNE09_25045 ENOG41067QW Transcriptional regulator GNE09_25050 ENOG4105F0F Oxalate decarboxylase GNE09_25065 ENOG4108MUZ hydrolase GNE09_25090 ENOG410829K Lysine exporter protein (Lyse ygga) GNE09_25105 ENOG4106D4I domain protein GNE09_25110 ENOG4107VRP DNA repair exonuclease GNE09_25130 ENOG4107QHE Choloylglycine hydrolase GNE09_25140 ENOG4105D7V transposase GNE09_25170 ENOG4105BZU Histidine kinase GNE09_25175 ENOG4105BZU Histidine kinase GNE09_25180 ENOG4108MJI response regulator GNE09_25190 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GNE09_25200 ENOG4105WN5 stage II sporulation protein GNE09_25285 ENOG410847I Transcriptional regulator, BadM Rrf2 family GNE09_25305 ENOG4105CMT Dihydroxyacetone kinase GNE09_25315 ENOG4105WAB arsR family transcriptional regulator GNE09_25320 ENOG4105F27 Major Facilitator GNE09_25330 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase GNE09_25395 ENOG4105F6J Alpha beta hydrolase fold GNE09_25430 ENOG4105D9U N-acetyltransferase GNE09_25450 ENOG4105C0R drug resistance transporter emrb qaca subfamily GNE09_25475 ENOG4105CDU Replicative dna helicase GNE09_25520 ENOG4105M6F mutator MutT protein GNE09_25530 ENOG4108MRH transcriptional regulatory protein GNE09_25540 ENOG4105CSH Transporter GNE09_25595 ENOG4108IBT Inherit from COG: transposase GNE09_25655 ENOG4108IBT Inherit from COG: transposase GNE09_25700 ENOG4107SFI Major Facilitator superfamily GNE09_25705 ENOG4105D06 uba thif-type nad fad binding protein GNE09_25720 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase GNE09_25750 ENOG4108JQ7 (ABC) transporter GNE09_25755 ENOG4105C3U ABC transporter GNE09_25760 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GNE09_25775 ENOG4105CIF Ornithine Cyclodeaminase GNE09_25800 ENOG4105DER m42 family GNE09_25820 ENOG4105CGU Enoyl-CoA hydratase GNE09_25845 ENOG4105CHH sulfate transporter GNE09_25855 ENOG4105CEY Amp-dependent synthetase and ligase GNE09_25860 ENOG4105D4P Coproporphyrinogen iii oxidase GNE09_25865 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase GNE09_25885 ENOG4107FQX Alpha-acetolactate decarboxylase GNE09_25920 ENOG410839P GNE09_25935 ENOG4105CDA abc transporter atp-binding protein GNE09_25940 ENOG4105DRP amino acid AbC transporter GNE09_25950 ENOG4105BZ1 (ABC) transporter GNE09_25955 ENOG4105BZ1 (ABC) transporter GNE09_25960 ENOG4105C26 Dehydrogenase GNE09_25965 ENOG4105D5Q Arginine ornithine antiporter GNE09_25975 ENOG4105CH6 catalase GNE09_25980 ENOG4107RKG DJ-1/PfpI family GNE09_25990 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF GNE09_26020 ENOG4105KPY Small multidrug resistance protein GNE09_26030 ENOG4105UBK short-chain dehydrogenase reductase GNE09_26040 ENOG4108YXU transcriptional regulator AsnC family GNE09_26075 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GNE09_26080 ENOG4106KNT transcriptional regulator GNE09_26090 ENOG4107RWR Sodium hydrogen exchanger GNE09_26125 ENOG4107T5V SNARE associated Golgi GNE09_26160 ENOG4105WEF catalase GNE09_26195 ENOG4107RBB ABC transporter, permease GNE09_26200 ENOG41069ER domain protein GNE09_26225 ENOG4105VZJ PTS System GNE09_26230 ENOG4105VCP PTS System GNE09_26235 ENOG4105EMD TRANSCRIPTIONal GNE09_26260 ENOG4108KGH TRANSCRIPTIONal GNE09_26270 ENOG41087NI Sulfite exporter TauE/SafE GNE09_26275 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase GNE09_26285 ENOG4105VFE sira family GNE09_26290 ENOG4105VFE sira family GNE09_26295 ENOG4107TPS domain protein GNE09_26300 ENOG4105VFE sira family GNE09_26305 ENOG4105XTG Pfam:DUF156 GNE09_26310 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase GNE09_26325 ENOG4105J4Q Transcriptional regulator GNE09_26365 ENOG4105ED1 spovr family GNE09_26370 ENOG4107Y03 Nitroreductase GNE09_26390 ENOG4108B31 Spore germination protein GNE09_26410 ENOG4105K63 Thioredoxin GNE09_26425 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GNE09_26435 ENOG4105C7N Xanthine uracil vitamin C permease GNE09_26445 ENOG4105C19 ABC transporter GNE09_26470 ENOG4108INS Transcriptional regulator GNE09_26520 ENOG4105C3F Signal peptidase i GNE09_26525 ENOG4105C19 ABC transporter GNE09_26545 ENOG4105DWF phosphomethylpyrimidine kinase GNE09_26550 ENOG4105D06 uba thif-type nad fad binding protein GNE09_26565 ENOG41080HI glycine oxidase GNE09_26570 ENOG4108VEU Thiamine monophosphate synthase GNE09_26580 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GNE09_26590 ENOG4105ETU transcriptional activator (TenA GNE09_26610 ENOG41080XQ Signal transduction protein with cbs domains GNE09_26740 ENOG4105E2Z phosphate ABC transporter (Permease GNE09_26745 ENOG4105C8U phosphate abc transporter GNE09_26750 ENOG4105CVA phosphate GNE09_26755 ENOG4105CE1 Ferrous iron transport protein b GNE09_26760 ENOG4105CE1 Ferrous iron transport protein b GNE09_26765 ENOG4105CE1 Ferrous iron transport protein b GNE09_26770 ENOG4108NHD germination protein GNE09_26785 ENOG4105E1V na solute symporter GNE09_26790 ENOG4106CAD Protein of unknown function (DUF3311) GNE09_26810 ENOG4105E2S oxidase) subunit II GNE09_26815 ENOG4105BZ9 Cytochrome C oxidase, subunit I GNE09_26840 ENOG4105MA6 gCN5-related N-acetyltransferase GNE09_26855 ENOG4105C7N Xanthine uracil vitamin C permease GNE09_26860 ENOG4105C85 amino acid GNE09_26880 ENOG4105DUX Transporter GNE09_26895 ENOG4107D63 GNE09_26900 ENOG4105VZ8 Transcriptional regulator GNE09_26905 ENOG41069ER domain protein GNE09_26910 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer GNE09_26915 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GNE09_27100 ENOG4105DHF Membrane GNE09_27110 ENOG4105KRN Transcriptional regulator, abrb family GNE09_27140 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GNE09_27155 ENOG4105K70 DNA-binding protein GNE09_27160 ENOG4105CVK Glutamate decarboxylase GNE09_27175 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family GNE09_27180 ENOG4105CZV ABC transporter GNE09_27250 ENOG4105WQG acetyltransferase GNE09_27260 ENOG41080TC multidrug resistance protein GNE09_27275 ENOG4105BZU Histidine kinase GNE09_27280 ENOG4105C19 ABC transporter GNE09_27310 ENOG4107RF6 penicillin-binding protein GNE09_27325 ENOG4108J5H Homocysteine s-methyltransferase GNE09_27330 ENOG4108IQI permease GNE09_27335 ENOG4105D7V transposase GNE09_27350 ENOG4105BZ4 penicillin-binding protein GNE09_27445 ENOG4105ES4 Nitrilase GNE09_27455 ENOG4107RF6 penicillin-binding protein GNE09_27485 ENOG4105T38 integral membrane protein GNE09_27490 ENOG4107VMI polysaccharide deacetylase GNE09_27505 ENOG4105DVE abc transporter atp-binding protein GNE09_27545 ENOG4105MZU cell filamentation protein GNE09_27555 ENOG4105EJQ L-serine dehydratase GNE09_27560 ENOG4105C44 Serine transporter GNE09_27570 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer GNE09_27585 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GNE09_27605 ENOG4105F6S Spore photoproduct lyase GNE09_27620 ENOG4107QHE Choloylglycine hydrolase GNE09_27625 ENOG4105FQP Beta-lactamase GNE09_27630 ENOG4105CNI cell division protein FtsW GNE09_27640 ENOG4105CJW magnesium transporter GNE09_27660 ENOG4108E1C hydrolase GNE09_27705 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) GNE09_27760 ENOG4107Y80 Major Facilitator superfamily GNE09_27780 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GNE09_27790 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GNE09_27795 ENOG4105BZU Histidine kinase GNE09_27805 ENOG4105CJZ response regulator GNE09_27820 ENOG4105D7V transposase GNE09_27905 ENOG4107EXU Short-chain dehydrogenase reductase Sdr GNE09_27945 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase GNE09_27980 ENOG4105BZ1 (ABC) transporter GNE09_28000 ENOG41067FT ParB-like nuclease domain GNE09_28045 ENOG4105IBP Cyclic peptide transporter GNE09_28050 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GNE09_28070 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) GNE09_28075 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GNE09_28090 ENOG4105C1G acyl-Coa dehydrogenase GNE09_28110 ENOG4105C0W non-ribosomal peptide synthetase GNE09_28110 ENOG4105C0W non-ribosomal peptide synthetase GNE09_28155 ENOG4107SET aldo keto reductase GNE09_28170 ENOG4105CHR reductase GNE09_28180 ENOG4105D2T synthase GNE09_28185 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr GNE09_28240 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GNE09_28245 ENOG4105C4R Atp-dependent dna helicase GNE09_28345 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GNE09_28355 ENOG4105K70 DNA-binding protein GNE09_28360 ENOG4105DQ6 Transposase GNE09_28375 ENOG4107JM4 Tetratricopeptide repeat GNE09_28405 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin GNE09_28415 ENOG4108XG2 Histidine kinase GNE09_28430 ENOG41067SE Tetr family transcriptional regulator GNE09_28490 ENOG4105CAQ asparagine synthetase GNE09_28495 ENOG4108RZE Tetr family transcriptional regulator GNE09_28510 ENOG4108IBT Inherit from COG: transposase GNE09_28525 ENOG4108IBT Inherit from COG: transposase GNE09_28535 ENOG4105D7V transposase GNE09_28585 ENOG4105D7V transposase GNE09_28590 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase GNE09_28605 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase GNE09_28610 ENOG4105DR5 peptidase GNE09_28680 ENOG4108WZA zeta toxin GNE09_28685 ENOG4105E4C Lytic transglycosylase catalytic GNE09_28695 ENOG41069ER domain protein GNE09_28750 ENOG4105D7V transposase GNE09_28785 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GNE09_28830 ENOG4105EKQ RNA-directed DNA polymerase GNE09_28985 ENOG4105D7V transposase GNE09_29085 ENOG4108S3A nucleotidyltransferase GNE09_29145 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GNE09_29175 ENOG4107ZTW SNARE associated Golgi GNE09_29205 ENOG41088CC tellurite resistance protein tehB GNE09_29280 ENOG4105DQ6 Transposase GNE09_29295 ENOG4105DQ6 Transposase GNE09_29400 ENOG4105E1K spore germination protein GNE09_29405 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family GNE09_29410 ENOG41073R8 VanW family GNE09_29415 ENOG4108A04 Beta-lactamase GNE09_29440 ENOG4105VUF Transcriptional regulator GNE09_29465 ENOG4105E1F short-chain dehydrogenase reductase GNE09_29470 ENOG4105VUF Transcriptional regulator GNE09_29475 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) GNE09_29565 ENOG4105DQ4 alcohol dehydrogenase GNE09_29570 ENOG4107RA9 decarboxylase GNE09_29590 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD GNE09_29600 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein GNE09_29615 ENOG4107VMI polysaccharide deacetylase GNE09_29720 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GNE09_29830 ENOG4105EKQ RNA-directed DNA polymerase GNE09_29870 ENOG4105KCF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) GNE09_29905 ENOG4105FB9 CRISPR-associated protein GNE09_30015 ENOG41061CK Antibiotic biosynthesis monooxygenase GNE09_30025 ENOG4105CNU cell division protein FtsK GNE09_30030 ENOG4105EKQ RNA-directed DNA polymerase GNE09_30215 ENOG4105D7V transposase