locus-tag class description BA201_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BA201_00015 ENOG410848D S4 domain protein YaaA BA201_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BA201_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BA201_00100 ENOG4105ZMH deoxynucleoside kinase BA201_00110 ENOG4105GTG Isochorismatase BA201_00115 ENOG4108Z6B deaminase BA201_00125 ENOG4105C6E dna polymerase iii BA201_00145 ENOG41067KS pro-sigma K processing BA201_00180 ENOG4105CXN decarboxylase BA201_00185 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BA201_00190 ENOG4105FA2 dna polymerase iii BA201_00195 ENOG4105MA4 psp1 domain protein BA201_00205 ENOG41060K3 Methyltransferase BA201_00215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BA201_00220 ENOG4105KRN Transcriptional regulator, abrb family BA201_00225 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BA201_00230 ENOG4105F8V Hydrolase, tatD family BA201_00235 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BA201_00245 ENOG4105XFA sporulation peptidase YabG BA201_00250 ENOG4105W42 Veg protein BA201_00265 ENOG4105DFT pur operon repressor BA201_00270 ENOG4105KME endoribonuclease L-psp BA201_00285 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BA201_00290 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BA201_00300 ENOG4108JA2 transcriptioN-repair coupling factor BA201_00305 ENOG4108M14 stage v sporulation protein t BA201_00315 ENOG4108IY2 MazG family BA201_00320 ENOG41082I2 s4 domain protein BA201_00325 ENOG4105VYY sporulation protein yabp BA201_00340 ENOG41060GV RNA binding s1 domain protein BA201_00360 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BA201_00365 ENOG4108UGV hypoxanthine phosphoribosyltransferase BA201_00370 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BA201_00385 ENOG4105C6T cysteine synthase BA201_00390 ENOG4105CRQ synthase (Component I) BA201_00395 ENOG4105DDQ anthranilate synthase BA201_00400 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BA201_00405 ENOG4105EEI dihydropteroate synthase BA201_00410 ENOG4105KRF dihydroneopterin aldolase BA201_00415 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BA201_00425 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BA201_00515 ENOG4108Z0C Uvrb UvrC protein BA201_00530 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BA201_00535 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) BA201_00540 ENOG4105CTP PilT protein domain protein BA201_00545 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BA201_00560 ENOG4105D7W serine acetyltransferase BA201_00575 ENOG4105C2N RNA methyltransferase TrmH family group 3 BA201_00580 ENOG4105M0M Tetracycline resistance protein BA201_00585 ENOG4105QIV RNA polymerase BA201_00595 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BA201_00620 ENOG4107Y49 methyltransferase BA201_00635 ENOG4105XPM ribosomal protein BA201_00740 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BA201_00765 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BA201_00775 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BA201_00785 ENOG41067V7 50S ribosomal protein L36 BA201_00810 ENOG4108JJB ABC transporter BA201_00815 ENOG4108JJB ABC transporter BA201_00820 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BA201_00825 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BA201_00850 ENOG4105D1F ATP-binding protein BA201_00865 ENOG4108NMV polysaccharide deacetylase BA201_00945 ENOG4105C8B TIGR00159 family BA201_00950 ENOG4107U5W ybbr family BA201_00965 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BA201_00990 ENOG4108PSK reductase BA201_00995 ENOG4108UMI ABC transporter, permease BA201_01000 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BA201_01005 ENOG4105D01 (LipO)protein BA201_01010 ENOG4105CB2 alcohol dehydrogenase BA201_01020 ENOG4105IQ5 FAD linked oxidase domain protein BA201_01035 ENOG4105C2C drug resistance transporter, Bcr CflA BA201_01055 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BA201_01060 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BA201_01065 ENOG4105C3U ABC transporter BA201_01070 ENOG4108JQ7 (ABC) transporter BA201_01100 ENOG4108J59 Extracellular solute-binding protein, family 5 BA201_01105 ENOG4108J59 Extracellular solute-binding protein, family 5 BA201_01115 ENOG4105II7 pyrroline-5-carboxylate reductase BA201_01125 ENOG4105E0C molybdate abc transporter BA201_01130 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BA201_01135 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BA201_01145 ENOG4105EGI Transcriptional regulator BA201_01165 ENOG4105F6E Acyl-transferase BA201_01185 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BA201_01205 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BA201_01225 ENOG4105C5H ABC transporter BA201_01235 ENOG4105DEF Extracellular solute-binding protein, family 5 BA201_01245 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BA201_01250 ENOG4105C3U ABC transporter BA201_01255 ENOG4108JQ7 (ABC) transporter BA201_01260 ENOG410667J hydrolase BA201_01285 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BA201_01290 ENOG4105ERH Fumarylacetoacetate hydrolase BA201_01300 ENOG4105CUB amino acid BA201_01305 ENOG4108SC4 )-transporter BA201_01310 ENOG4105CPF Cell wall formation (By similarity) BA201_01315 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BA201_01340 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BA201_01345 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BA201_01355 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BA201_01455 ENOG4105K8N protein family UPF0079, ATPase BA201_01460 ENOG41072GX Peptidase M22 Glycoprotease BA201_01465 ENOG410801F ribosomal-protein-alanine acetyltransferase BA201_01470 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BA201_01475 ENOG4105C5H ABC transporter BA201_01490 ENOG4108TYN CAAX amino terminal protease family protein BA201_01505 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BA201_01510 ENOG4105C7N Xanthine uracil vitamin C permease BA201_01520 ENOG4105BZU Histidine kinase BA201_01545 ENOG4107ZXU DSBA oxidoreductase BA201_01590 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BA201_01610 ENOG4105SX7 Transporter BA201_01635 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BA201_01640 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BA201_01645 ENOG4105C83 adenylosuccinate lyase BA201_01655 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BA201_01665 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii BA201_01680 ENOG4108V3E phosphoribosylglycinamide formyltransferase BA201_01685 ENOG4105DC1 bifunctional purine biosynthesis protein purh BA201_01690 ENOG4105C12 Phosphoribosylglycinamide synthetase BA201_01715 ENOG4105C4R Atp-dependent dna helicase BA201_01720 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BA201_01740 ENOG4108W2Y isochorismatase BA201_01745 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BA201_01750 ENOG4108UMI ABC transporter, permease BA201_01755 ENOG4105D01 (LipO)protein BA201_01770 ENOG410834F Transcriptional regulator BA201_01775 ENOG4107I77 yiaA/B two helix domain BA201_01785 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BA201_01795 ENOG4105CBD Diacylglycerol kinase BA201_01805 ENOG4108JPW Aminotransferase BA201_01815 ENOG4105C26 Dehydrogenase BA201_01820 ENOG4105KPY Small multidrug resistance protein BA201_01845 ENOG4105D9N nucleoside BA201_01850 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BA201_01860 ENOG4108W15 Protein of unknown function (DUF1456) BA201_01875 ENOG4105DTQ mandelate racemase muconate lactonizing BA201_01885 ENOG4105DFD Na H antiporter BA201_01905 ENOG4105D3R alkyl hydroperoxide reductase BA201_01910 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BA201_01915 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BA201_01920 ENOG4107W7X Aldolase BA201_01925 ENOG4105EHG Permease protein BA201_01930 ENOG4105DQ5 transport system permease protein BA201_01935 ENOG4108V5C ABC transporter BA201_01940 ENOG4105CAY ferredoxin--nadp reductase BA201_01955 ENOG4106UIA BA201_01960 ENOG4106UIA BA201_01975 ENOG4105BZU Histidine kinase BA201_01995 ENOG410756H nucleotidyltransferase BA201_02000 ENOG4105D2S major facilitator superfamily BA201_02015 ENOG4105E5Q amino acid AbC transporter BA201_02020 ENOG4105EAB amino acid AbC transporter BA201_02025 ENOG4105CDA abc transporter atp-binding protein BA201_02030 ENOG4105C8Q Methyl-accepting chemotaxis BA201_02045 ENOG4105DBV ornithine carbamoyltransferase BA201_02055 ENOG4105C5B carbamate kinase BA201_02060 ENOG4108W63 CRP FNR family transcriptional regulator BA201_02070 ENOG4105DNP FAD linked oxidase domain protein BA201_02080 ENOG4105CI1 PTS System BA201_02095 ENOG4105C9U ATP-dependent DNA helicase RecQ BA201_02100 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase BA201_02105 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) BA201_02110 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BA201_02130 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BA201_02135 ENOG4105D2X ABC transporter substrate-binding protein BA201_02170 ENOG41062JF Transcriptional regulator BA201_02185 ENOG4105DEU major facilitator superfamily BA201_02200 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BA201_02215 ENOG4108N0M stress protein BA201_02220 ENOG4106FN3 tellurium resistance protein BA201_02225 ENOG4106FN3 tellurium resistance protein BA201_02230 ENOG4107TS3 membrane protein, TerC BA201_02235 ENOG4108TTB tellurium resistance protein BA201_02250 ENOG41068PA UPF0435 protein BA201_02255 ENOG4105KJF protein tyrosine phosphatase BA201_02265 ENOG4107U9T Pfam:Ribonuclease_BN BA201_02270 ENOG4105C59 p-type ATPase BA201_02275 ENOG4108IPJ Membrane BA201_02285 ENOG4105C3F Signal peptidase i BA201_02295 ENOG4107ZTW SNARE associated Golgi BA201_02310 ENOG410606W general stress protein BA201_02315 ENOG4105UPD Calcium Proton BA201_02350 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BA201_02355 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BA201_02365 ENOG4108JUB Transcriptional regulator BA201_02375 ENOG4108IQI permease BA201_02410 ENOG4108A04 Beta-lactamase BA201_02425 ENOG4105CKK Glycosyl transferase, family 2 BA201_02430 ENOG4107QQG Dehydrogenase BA201_02435 ENOG4105C3I Nad-dependent epimerase dehydratase BA201_02455 ENOG4105F1A Pyruvate formate-lyase BA201_02460 ENOG4108QBV Monogalactosyldiacylglycerol synthase BA201_02475 ENOG4105CI2 imidazolone-5-propionate hydrolase BA201_02480 ENOG4105ECP epimerase BA201_02510 ENOG41067AE Membrane-bound metal-dependent hydrolase BA201_02515 ENOG4105CEN a g-specific adenine glycosylase BA201_02520 ENOG4106BXE BA201_02540 ENOG4105BZ1 (ABC) transporter BA201_02545 ENOG4107NBY Membrane BA201_02550 ENOG4105CBC glutamate synthase BA201_02560 ENOG4108IUW ABC transporter BA201_02580 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BA201_02585 ENOG4105G5W regulator Fur family BA201_02695 ENOG4105CDY transcriptional regulatory protein BA201_02705 ENOG4108JQC penicillin-binding protein 1A BA201_02710 ENOG4108R9S DSBA oxidoreductase BA201_02720 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BA201_02730 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BA201_02735 ENOG4105BZU Histidine kinase BA201_02740 ENOG4105CYN Serine protein kinase BA201_02745 ENOG4106AKX UPF0229 protein BA201_02755 ENOG4108MK9 spermidine N(1)-acetyltransferase BA201_02760 ENOG4105C94 Transporter BA201_02775 ENOG4105DZ6 Band 7 protein BA201_02785 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BA201_02790 ENOG4108V9W transcriptional regulatory protein BA201_02795 ENOG4105D4T Citrate transporter BA201_02820 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BA201_02825 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BA201_02830 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BA201_02835 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BA201_02840 ENOG4105BZ7 extracellular solute-binding protein family 1 BA201_02845 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BA201_02850 ENOG4108STX response regulator BA201_02855 ENOG41062D9 Histidine kinase BA201_02880 ENOG4108MRH transcriptional regulatory protein BA201_02890 ENOG4105C6K Malic enzyme BA201_02900 ENOG4108UZ3 Transporter BA201_02905 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BA201_02915 ENOG4105BZU Histidine kinase BA201_02935 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BA201_02940 ENOG4108JB9 formate dehydrogenase BA201_02960 ENOG4105CUB amino acid BA201_02975 ENOG4105C59 p-type ATPase BA201_02980 ENOG4105DAP Nicotinate phosphoribosyltransferase BA201_03010 ENOG41073R8 VanW family BA201_03015 ENOG4108KGH TRANSCRIPTIONal BA201_03020 ENOG4105D9N nucleoside BA201_03025 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BA201_03030 ENOG4105C37 (CBS) domain BA201_03035 ENOG4108IJ0 Aspartate ammonia-lyase BA201_03040 ENOG4105DAA L-lactate BA201_03055 ENOG4105DUX Transporter BA201_03060 ENOG4108MES Periplasmic binding protein BA201_03065 ENOG4105DQ5 transport system permease protein BA201_03070 ENOG4108IHU transport system permease protein BA201_03075 ENOG4105E0A ABC, transporter BA201_03085 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BA201_03090 ENOG4105EXW epimerase dehydratase BA201_03100 ENOG4107T89 von Willebrand factor, type A BA201_03105 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BA201_03110 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BA201_03120 ENOG4105BZU Histidine kinase BA201_03125 ENOG4105D5Q Arginine ornithine antiporter BA201_03130 ENOG4107414 GntR family transcriptional regulator BA201_03135 ENOG4105C5Y PTS System BA201_03140 ENOG4105CG3 alpha amylase, catalytic region BA201_03155 ENOG4105E1K spore germination protein BA201_03160 ENOG4108XG2 Histidine kinase BA201_03165 ENOG4105WH1 Two component transcriptional regulator luxr family BA201_03170 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BA201_03180 ENOG4105CRN Aminoglycoside phosphotransferase BA201_03185 ENOG4105BZG amino acid carrier protein BA201_03195 ENOG4105CDA abc transporter atp-binding protein BA201_03200 ENOG4105CT1 (ABC) transporter BA201_03205 ENOG4105EAD ABC transporter BA201_03210 ENOG4105DRP amino acid AbC transporter BA201_03215 ENOG4108IQI permease BA201_03240 ENOG4105D29 Helix-turn-helix type 11 domain protein BA201_03245 ENOG4105NAE bifunctional deaminase-reductase domain protein BA201_03250 ENOG4105BZU Histidine kinase BA201_03265 ENOG4105CHH sulfate transporter BA201_03270 ENOG41068KF Universal stress protein BA201_03280 ENOG4105CXY transporter BA201_03285 ENOG41067TZ transcriptional regulator, MarR family BA201_03290 ENOG4105C0R drug resistance transporter emrb qaca subfamily BA201_03295 ENOG4105ETE Transcriptional regulator (LacI family BA201_03300 ENOG4108RVA ribokinase BA201_03310 ENOG4105C2J ABC transporter BA201_03315 ENOG4105CNN ABC, transporter BA201_03320 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BA201_03325 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BA201_03355 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) BA201_03385 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BA201_03390 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BA201_03395 ENOG41069ER domain protein BA201_03400 ENOG4105VZ8 Transcriptional regulator BA201_03405 ENOG4107D63 BA201_03420 ENOG4105DUX Transporter BA201_03440 ENOG4105C85 amino acid BA201_03445 ENOG4105C7N Xanthine uracil vitamin C permease BA201_03460 ENOG4105MA6 gCN5-related N-acetyltransferase BA201_03485 ENOG4105BZ9 Cytochrome C oxidase, subunit I BA201_03490 ENOG4105E2S oxidase) subunit II BA201_03510 ENOG4106CAD Protein of unknown function (DUF3311) BA201_03515 ENOG4105E1V na solute symporter BA201_03535 ENOG4105CE1 Ferrous iron transport protein b BA201_03540 ENOG4105CE1 Ferrous iron transport protein b BA201_03545 ENOG4105CE1 Ferrous iron transport protein b BA201_03550 ENOG4105CVA phosphate BA201_03555 ENOG4105C8U phosphate abc transporter BA201_03560 ENOG4105E2Z phosphate ABC transporter (Permease BA201_03685 ENOG41080XQ Signal transduction protein with cbs domains BA201_03705 ENOG4105ETU transcriptional activator (TenA BA201_03715 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BA201_03725 ENOG4108VEU Thiamine monophosphate synthase BA201_03730 ENOG41080HI glycine oxidase BA201_03745 ENOG4105D06 uba thif-type nad fad binding protein BA201_03750 ENOG4105DWF phosphomethylpyrimidine kinase BA201_03785 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) BA201_03800 ENOG4108INS Transcriptional regulator BA201_03810 ENOG4105C7N Xanthine uracil vitamin C permease BA201_03820 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BA201_03840 ENOG4105C5Y PTS System BA201_03855 ENOG4105K63 Thioredoxin BA201_03875 ENOG4108B31 Spore germination protein BA201_03895 ENOG4107Y03 Nitroreductase BA201_03920 ENOG4105ED1 spovr family BA201_03930 ENOG4105J4Q Transcriptional regulator BA201_03945 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BA201_03950 ENOG4105XTG Pfam:DUF156 BA201_03955 ENOG4105VFE sira family BA201_03960 ENOG4107TPS domain protein BA201_03965 ENOG4105VFE sira family BA201_03970 ENOG4105VFE sira family BA201_03975 ENOG41085GJ domain protein BA201_03980 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BA201_03985 ENOG41087NI Sulfite exporter TauE/SafE BA201_03995 ENOG4108KGH TRANSCRIPTIONal BA201_04020 ENOG4105EMD TRANSCRIPTIONal BA201_04025 ENOG4105VCP PTS System BA201_04030 ENOG4105VZJ PTS System BA201_04050 ENOG41069ER domain protein BA201_04055 ENOG4107RBB ABC transporter, permease BA201_04060 ENOG4105C19 ABC transporter BA201_04090 ENOG4105WEF catalase BA201_04125 ENOG4107T5V SNARE associated Golgi BA201_04155 ENOG4105CUB amino acid BA201_04160 ENOG4107RWR Sodium hydrogen exchanger BA201_04170 ENOG4106KNT transcriptional regulator BA201_04175 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BA201_04210 ENOG4108YXU transcriptional regulator AsnC family BA201_04215 ENOG4105CH7 arginosuccinase BA201_04220 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BA201_04230 ENOG4105KPY Small multidrug resistance protein BA201_04260 ENOG4105NF4 modulator of drug activity BA201_04265 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BA201_04270 ENOG4105E5W Transporter BA201_04280 ENOG4107RKG DJ-1/PfpI family BA201_04295 ENOG4105D5Q Arginine ornithine antiporter BA201_04300 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BA201_04310 ENOG4105C26 Dehydrogenase BA201_04315 ENOG4105BZ1 (ABC) transporter BA201_04320 ENOG4105BZ1 (ABC) transporter BA201_04330 ENOG4105DRP amino acid AbC transporter BA201_04335 ENOG4105CDA abc transporter atp-binding protein BA201_04350 ENOG410839P BA201_04360 ENOG4108UH6 UPF0754 membrane protein BA201_04370 ENOG4105BZU Histidine kinase BA201_04375 ENOG4105WH1 Two component transcriptional regulator luxr family BA201_04385 ENOG4107FQX Alpha-acetolactate decarboxylase BA201_04390 ENOG4108VX5 3-methyladenine DNA glycosylase BA201_04405 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BA201_04410 ENOG4105D4P Coproporphyrinogen iii oxidase BA201_04415 ENOG4105CEY Amp-dependent synthetase and ligase BA201_04430 ENOG4105CHH sulfate transporter BA201_04455 ENOG4105CGU Enoyl-CoA hydratase BA201_04475 ENOG4105DER m42 family BA201_04495 ENOG4105CTU Proline racemase BA201_04500 ENOG4105CIF Ornithine Cyclodeaminase BA201_04515 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BA201_04525 ENOG4108JQ7 (ABC) transporter BA201_04585 ENOG4108IBT Inherit from COG: transposase BA201_04635 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) BA201_04700 ENOG4105CSH Transporter BA201_04710 ENOG4108MRH transcriptional regulatory protein BA201_04770 ENOG4105CDU Replicative dna helicase BA201_04795 ENOG4105C0R drug resistance transporter emrb qaca subfamily BA201_04805 ENOG4105D9U N-acetyltransferase BA201_04825 ENOG4105F6J Alpha beta hydrolase fold BA201_04855 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BA201_04870 ENOG4105CMT Dihydroxyacetone kinase BA201_04880 ENOG4105CMT Dihydroxyacetone kinase BA201_04930 ENOG4108WC5 Alpha Beta Hydrolase Fold protein BA201_04970 ENOG4105WN5 stage II sporulation protein BA201_04980 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BA201_04990 ENOG4108MJI response regulator BA201_04995 ENOG4105BZU Histidine kinase BA201_05000 ENOG4105BZU Histidine kinase BA201_05020 ENOG4105K8R UPF0145 protein BA201_05035 ENOG4107QHE Choloylglycine hydrolase BA201_05055 ENOG4107VRP DNA repair exonuclease BA201_05060 ENOG4106D4I domain protein BA201_05090 ENOG4108MUZ hydrolase BA201_05110 ENOG4105F0F Oxalate decarboxylase BA201_05115 ENOG41067QW Transcriptional regulator BA201_05120 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BA201_05135 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BA201_05150 ENOG4105DU6 RNA polymerase BA201_05175 ENOG4105EEM helicase BA201_05185 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BA201_05210 ENOG4105K59 histidine triad (HIT) protein BA201_05240 ENOG410905X membrane-flanked domain protein BA201_05245 ENOG4105CKV Membrane BA201_05280 ENOG410905X membrane-flanked domain protein BA201_05285 ENOG4105CKV Membrane BA201_05290 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BA201_05295 ENOG4105BZ4 penicillin-binding protein BA201_05305 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BA201_05310 ENOG4105C1Q protoporphyrinogen oxidase BA201_05335 ENOG4105NA0 Transcriptional regulator BA201_05350 ENOG4105ECB domain protein BA201_05370 ENOG4108MK9 spermidine N(1)-acetyltransferase BA201_05380 ENOG4106AXD BA201_05385 ENOG4108RQ5 Beta-lactamase domain-containing protein BA201_05390 ENOG4105DF9 Lipoate-protein, ligase BA201_05400 ENOG4105CEY Amp-dependent synthetase and ligase BA201_05410 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein BA201_05415 ENOG4108I5D sulfate abc transporter BA201_05420 ENOG4105ECW sulfate abc transporter BA201_05425 ENOG4108IJ6 ABC transporter BA201_05490 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) BA201_05495 ENOG4107RN3 metallophosphoesterase BA201_05500 ENOG4107TVP HD domain protein BA201_05510 ENOG4108AEY RNA polymerase sigma factor BA201_05515 ENOG41086D8 Transcriptional regulator BA201_05530 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BA201_05550 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BA201_05555 ENOG4105C8Q Methyl-accepting chemotaxis BA201_05560 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) BA201_05570 ENOG4107QP3 malate synthase g BA201_05590 ENOG4105VEQ Cold shock protein BA201_05625 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BA201_05630 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BA201_05670 ENOG4105ERH Fumarylacetoacetate hydrolase BA201_05680 ENOG4105C8Y Acetylornithine aminotransferase BA201_05685 ENOG4106BKT UPF0344 protein BA201_05695 ENOG4105CAQ asparagine synthetase BA201_05700 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BA201_05705 ENOG4105CH6 catalase BA201_05710 ENOG4105BZU Histidine kinase BA201_05725 ENOG4108VPT UPF0234 protein BA201_05730 ENOG4105QNR S1 RNA binding domain protein BA201_05735 ENOG4105CNA YD repeat protein BA201_05745 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BA201_05755 ENOG4107AYK membrAne BA201_05760 ENOG41073B9 BA201_05770 ENOG4108KP7 hydrolase BA201_05780 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BA201_05810 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BA201_05815 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BA201_05830 ENOG4105C31 Tryptophanyl-tRNA synthetase BA201_05845 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BA201_05850 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BA201_05860 ENOG4108JQ7 (ABC) transporter BA201_05865 ENOG4105UQX Mate efflux family protein BA201_05885 ENOG4108ZCF integral membrane protein BA201_05895 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BA201_05905 ENOG4105DPN Oligoendopeptidase f BA201_05915 ENOG4108Z18 K06886 hemoglobin BA201_05920 ENOG4105MIX Adenylate cyclase BA201_05925 ENOG4106EFP UPF0738 protein BA201_05935 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BA201_05940 ENOG4105EMS pseudouridine synthase BA201_05960 ENOG4105K64 Glycosyl transferase, family 2 BA201_05980 ENOG4107TVC Glycosyl transferase, family 2 BA201_06000 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BA201_06005 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BA201_06015 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BA201_06065 ENOG4108ZMI UPF0477 protein BA201_06090 ENOG4105CK7 Sodium proline symporter BA201_06095 ENOG4105CRQ synthase (Component I) BA201_06100 ENOG4105DDQ anthranilate synthase BA201_06105 ENOG4108I0Q anthranilate phosphoribosyltransferase BA201_06110 ENOG4105DK0 Indole-3-glycerol phosphate synthase BA201_06115 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase BA201_06120 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BA201_06125 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) BA201_06190 ENOG4105C7S Dehydrogenase BA201_06220 ENOG4108IUX (ABC) transporter BA201_06225 ENOG4105RHA ABC transporter, permease BA201_06255 ENOG4105DZ1 carboxypeptidase BA201_06260 ENOG4105VFR signal peptidase BA201_06295 ENOG4105C26 Dehydrogenase BA201_06300 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BA201_06305 ENOG4105F38 ABC transporter, permease BA201_06310 ENOG4105D38 putrescine abc transporter BA201_06315 ENOG4107RUE extracellular solute-binding protein family 1 BA201_06325 ENOG4105EYF MMPL domain protein BA201_06335 ENOG4108YBP pseudouridine synthase BA201_06345 ENOG4105K4I Scp-like extracellular BA201_06350 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BA201_06355 ENOG4105CQB FAD linked oxidase domain protein BA201_06370 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BA201_06375 ENOG4105BZU Histidine kinase BA201_06380 ENOG4105JXH GntR family transcriptional regulator BA201_06400 ENOG4106A3R peptidase BA201_06410 ENOG4108QTI )-transporter BA201_06415 ENOG4107TS3 membrane protein, TerC BA201_06420 ENOG4105CZN Potassium uptake protein BA201_06425 ENOG410681C small acid-soluble spore protein BA201_06430 ENOG4108Z7G MaoC domain protein dehydratase BA201_06450 ENOG4105CHR reductase BA201_06480 ENOG4105C4Y ABC transporter BA201_06485 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BA201_06490 ENOG4107RCV ABC transporter, permease BA201_06510 ENOG4105E98 transcriptional regulator DeoR family BA201_06525 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BA201_06535 ENOG4105PXI polysaccharide deacetylase BA201_06545 ENOG4105BZU Histidine kinase BA201_06550 ENOG41090MY MarR family Transcriptional regulator BA201_06560 ENOG4106DF1 BA201_06570 ENOG4105BZU Histidine kinase BA201_06575 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BA201_06580 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BA201_06585 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BA201_06625 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BA201_06630 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BA201_06635 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BA201_06640 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BA201_06645 ENOG4105CZV ABC transporter BA201_06655 ENOG4105CJ1 ABC, transporter BA201_06695 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BA201_06700 ENOG4105EA8 2-Nitropropane dioxygenase BA201_06705 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BA201_06715 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BA201_06740 ENOG4105NQC Flavodoxin BA201_06780 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BA201_06810 ENOG4105CZN Potassium uptake protein BA201_06815 ENOG41063Y9 BA201_06820 ENOG4105KBJ sporulation protein ytfj BA201_06840 ENOG4105CM2 brancheD-chain amino acid aminotransferase BA201_06845 ENOG4105C7K acetolactate synthase BA201_06850 ENOG4108ZP8 Acetolactate synthase small subunit BA201_06855 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BA201_06870 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BA201_06885 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BA201_06890 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BA201_06895 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BA201_06900 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BA201_06905 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BA201_06910 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BA201_06920 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase BA201_06925 ENOG4107RVV histidinol phosphate phosphatase, hisj family BA201_06940 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BA201_06945 ENOG4105E0M Sulfatase BA201_06955 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BA201_06975 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BA201_06980 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BA201_06990 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BA201_06995 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BA201_07000 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BA201_07005 ENOG4105C8J )-transporter BA201_07025 ENOG4105DFD Na H antiporter BA201_07045 ENOG4105ENE Histidine kinase BA201_07050 ENOG4105WH1 Two component transcriptional regulator luxr family BA201_07070 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BA201_07095 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BA201_07115 ENOG4105CJ3 phosphate transporter BA201_07120 ENOG4107GRR phosphate transport regulator BA201_07125 ENOG4105BZ4 penicillin-binding protein BA201_07140 ENOG4105BZU Histidine kinase BA201_07145 ENOG4105I3N Conserved Protein BA201_07160 ENOG4105BZU Histidine kinase BA201_07165 ENOG4105D3A purine nucleoside phosphorylase DeoD-type BA201_07190 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BA201_07195 ENOG4105DZ1 carboxypeptidase BA201_07200 ENOG4108JIC nucleoside recognition domain protein BA201_07210 ENOG4105FE9 pseudouridine synthase BA201_07215 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BA201_07220 ENOG4107TWT Cytochrome c biogenesis protein BA201_07225 ENOG4105CRE cytochrome C BA201_07230 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BA201_07235 ENOG4105BZU Histidine kinase BA201_07240 ENOG4108WBT adenosyltransferase BA201_07255 ENOG4108SAX Membrane BA201_07270 ENOG4105C9U ATP-dependent DNA helicase RecQ BA201_07275 ENOG4105I7S Abortive infection protein BA201_07285 ENOG4107RGJ metallophosphoesterase BA201_07290 ENOG4108XDN Transcriptional regulator BA201_07295 ENOG4108S6Z Negative regulator of genetic competence BA201_07320 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BA201_07325 ENOG4107RB3 L-asparaginase BA201_07340 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) BA201_07355 ENOG4105S2F BA201_07360 ENOG41065D1 BA201_07390 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BA201_07405 ENOG4105XXQ heptaprenyl diphosphate synthase component I BA201_07415 ENOG4105EAH synthase BA201_07420 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BA201_07425 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BA201_07430 ENOG4105D49 3-dehydroquinate synthase BA201_07440 ENOG41068YB TPR repeat-containing protein BA201_07455 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BA201_07460 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BA201_07495 ENOG4108JYZ YitT family BA201_07505 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BA201_07510 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BA201_07520 ENOG4105FJR Lmbe family BA201_07525 ENOG4105CPK Glycosyl transferase (Group 1 BA201_07545 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BA201_07560 ENOG4105DVT helicase BA201_07565 ENOG4105YAC BA201_07585 ENOG4105CSM endonuclease III BA201_07595 ENOG4105BZ4 penicillin-binding protein BA201_07635 ENOG4106F55 Protein of unknown function (DUF1273) BA201_07650 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BA201_07685 ENOG4105DVT helicase BA201_07690 ENOG4105CTD carboxy-peptidase BA201_07700 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BA201_07710 ENOG4105C2W permease BA201_07715 ENOG4105DHF Membrane BA201_07720 ENOG410890F Dynamin family BA201_07730 ENOG4108W0I acetyltransferase BA201_07740 ENOG4105KHC sulfurtransferase BA201_07795 ENOG4105HTX biosynthesis protein BA201_07825 ENOG4105EKQ RNA-directed DNA polymerase BA201_07835 ENOG4105CPK Glycosyl transferase (Group 1 BA201_07850 ENOG4108SZE gCN5-related N-acetyltransferase BA201_07870 ENOG41081VK Ribonuclease BA201_07935 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BA201_07945 ENOG4107RWR Sodium hydrogen exchanger BA201_07950 ENOG4105CN5 Metallo-Beta-Lactamase BA201_07955 ENOG4108Z5V transcriptional regulator, merr family BA201_07965 ENOG4105H67 Protein of unknown function (DUF421) BA201_07970 ENOG41080C8 DUF218 domain BA201_08005 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BA201_08015 ENOG4107R0U MotA TolQ exbB proton channel BA201_08020 ENOG4105ER2 Ompa motb domain protein BA201_08025 ENOG4107YTP response regulator receiver protein BA201_08030 ENOG4105CBS Chea signal transduction histidine kinase BA201_08035 ENOG4105DD5 Flagellar motor switch protein BA201_08050 ENOG4105BZU Histidine kinase BA201_08070 ENOG4105E1Q flagellar hook-associated protein BA201_08075 ENOG4105DTJ flagellar hook-associated protein BA201_08080 ENOG4107TPX flagellar hook-associated BA201_08095 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BA201_08100 ENOG4108ZC9 flagellar basal-body rod protein flgc BA201_08105 ENOG41075Z6 flagellar hook-basal body complex protein fliE BA201_08110 ENOG4107U2N Flagellar M-ring protein BA201_08115 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BA201_08145 ENOG4105BZE flagellar hook protein, FlgE BA201_08160 ENOG4107R88 Chemotaxis protein (CheV) BA201_08170 ENOG4105I03 Flagellin BA201_08175 ENOG4105I03 Flagellin BA201_08180 ENOG4105I03 Flagellin BA201_08185 ENOG4105I03 Flagellin BA201_08190 ENOG4105I03 Flagellin BA201_08195 ENOG4105E4C Lytic transglycosylase catalytic BA201_08205 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BA201_08210 ENOG4105DD5 Flagellar motor switch protein BA201_08220 ENOG4105CN7 Flagellar biosynthetic protein FliP BA201_08225 ENOG4105VS8 Flagellar biosynthetic protein fliq BA201_08235 ENOG4105D00 flagellar biosynthetic protein flhB BA201_08240 ENOG4105D7B Flagellar biosynthesis protein flha BA201_08245 ENOG4105FZW flagellar biosynthesis regulator FlhF BA201_08250 ENOG4105KTQ flagellar basal-body rod protein BA201_08255 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BA201_08285 ENOG4105KAC Antibiotic biosynthesis monooxygenase BA201_08310 ENOG4105DUM transcriptional regulator, lysR family BA201_08325 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component BA201_08355 ENOG4105CVJ phosphoglycerate mutase BA201_08365 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) BA201_08385 ENOG4105CAQ asparagine synthetase BA201_08405 ENOG4105PGM cation diffusion facilitator family transporter BA201_08415 ENOG4105DRR Transcriptional regulator, GntR family BA201_08420 ENOG4108UZ3 Transporter BA201_08430 ENOG4105CKI cobalamin synthesis protein BA201_08435 ENOG4108PJD permease BA201_08450 ENOG4105DFD Na H antiporter BA201_08455 ENOG4105VUF Transcriptional regulator BA201_08465 ENOG4105C9Q fumarate hydratase class II BA201_08480 ENOG4107QJQ Mate efflux family protein BA201_08485 ENOG4105EC3 peptidase S51, dipeptidase E BA201_08505 ENOG4107QIV Cytochrome c biogenesis protein BA201_08510 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BA201_08520 ENOG4107JM4 Tetratricopeptide repeat BA201_08535 ENOG4105BZC d-serine deaminase BA201_08540 ENOG4106BRA Membrane BA201_08575 ENOG4105CJ1 ABC, transporter BA201_08595 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BA201_08610 ENOG4108IJ0 Aspartate ammonia-lyase BA201_08615 ENOG4105C6K Malic enzyme BA201_08675 ENOG4105E09 nadh pyrophosphatase BA201_08690 ENOG4105CSR polyphosphate kinase 2 BA201_08695 ENOG4105U3E Transcriptional regulator BA201_08710 ENOG4105DXI Major Facilitator superfamily BA201_08720 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BA201_08725 ENOG4105EU0 Major facilitator Superfamily BA201_08730 ENOG4105C6T cysteine synthase BA201_08750 ENOG4105C8J )-transporter BA201_08760 ENOG4105X5K response regulator receiver protein BA201_08765 ENOG4105H67 Protein of unknown function (DUF421) BA201_08785 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BA201_08790 ENOG4105CHR reductase BA201_08795 ENOG4105CM2 brancheD-chain amino acid aminotransferase BA201_08800 ENOG4105C7K acetolactate synthase BA201_08810 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BA201_08815 ENOG4105C01 Dihydroxy-acid dehydratase BA201_08820 ENOG4105C7B Threonine dehydratase BA201_08845 ENOG4105C6X Major Facilitator BA201_08850 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BA201_08860 ENOG4105DY9 regulatoR BA201_08865 ENOG4105CYC Transferase BA201_08880 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BA201_08910 ENOG41068WN BA201_08930 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BA201_08935 ENOG4105C72 UPF0176 protein BA201_08945 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BA201_08955 ENOG4105C0X amino acid BA201_08980 ENOG4105K8R UPF0145 protein BA201_08995 ENOG4107RHR regulatoR BA201_09005 ENOG4105D9N nucleoside BA201_09010 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BA201_09055 ENOG4107RAQ aminopeptidase BA201_09065 ENOG4107R16 Multicopper oxidase BA201_09105 ENOG4108T5E Copper resistance protein BA201_09110 ENOG4105KTB nuclear export factor GLE1 BA201_09115 ENOG4107RT3 EamA-like transporter family BA201_09120 ENOG4105GZI Transcriptional regulator BA201_09130 ENOG4107ZXU DSBA oxidoreductase BA201_09135 ENOG4108TVJ Nitroreductase BA201_09145 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BA201_09150 ENOG4106F5Q Membrane BA201_09155 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BA201_09165 ENOG4105CKI cobalamin synthesis protein BA201_09175 ENOG4105C0Z ABC transporter BA201_09180 ENOG4108IV0 ABC, transporter BA201_09185 ENOG4105C32 Amino acid ABC transporter (Permease) BA201_09195 ENOG4105SKE transcriptional Regulator LysR family BA201_09215 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes BA201_09225 ENOG4105C4M (Ubiquinol oxidase) subunit I BA201_09230 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BA201_09235 ENOG4108JJ9 ABC, transporter BA201_09240 ENOG4108JJ8 (ABC) transporter BA201_09250 ENOG4105K64 Glycosyl transferase, family 2 BA201_09260 ENOG4108UT6 Transferase hexapeptide repeat containing protein BA201_09315 ENOG4105BZ1 (ABC) transporter BA201_09320 ENOG4105EFI regulatoR BA201_09325 ENOG4105BZU Histidine kinase BA201_09340 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BA201_09345 ENOG4108ZJ4 polysaccharide deacetylase BA201_09365 ENOG4105D6E homoserine dehydrogenase BA201_09390 ENOG4108KGH TRANSCRIPTIONal BA201_09400 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BA201_09405 ENOG4105BZU Histidine kinase BA201_09410 ENOG4107VMI polysaccharide deacetylase BA201_09420 ENOG4105KT7 mgtC SapB transporter BA201_09425 ENOG4105VRR gCN5-related N-acetyltransferase BA201_09435 ENOG4105DUU IucA IucC family protein BA201_09440 ENOG4105CEY Amp-dependent synthetase and ligase BA201_09455 ENOG4108WBH protein TIM barrel BA201_09460 ENOG4105YWU small acid-soluble spore protein BA201_09470 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BA201_09475 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BA201_09525 ENOG4105KRN Transcriptional regulator, abrb family BA201_09535 ENOG4105YVS arsR family transcriptional regulator BA201_09540 ENOG4105CPC Aldo Keto reductase BA201_09545 ENOG4107XZQ multidrug resistance protein BA201_09555 ENOG4105KAF membrAne BA201_09580 ENOG4105C8Q Methyl-accepting chemotaxis BA201_09595 ENOG4108K88 Membrane BA201_09600 ENOG4108WPJ Ferritin-like domain BA201_09615 ENOG4105DEN Luciferase family BA201_09630 ENOG4105VMI -acetyltransferase BA201_09635 ENOG4107QM2 Aldo Keto reductase BA201_09640 ENOG4105CKI cobalamin synthesis protein BA201_09650 ENOG4105DSE periplasmic solute binding protein BA201_09655 ENOG4105K4T epimerase BA201_09665 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BA201_09710 ENOG4107T5V SNARE associated Golgi BA201_09725 ENOG4108PJD permease BA201_09735 ENOG4108S4H thioesterase Superfamily protein BA201_09740 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BA201_09760 ENOG4105SXS Protein of unknown function (DUF456) BA201_09765 ENOG4105C37 (CBS) domain BA201_09785 ENOG4108Z7R Chaperone CsaA BA201_09800 ENOG4108ZRV stage ii sporulation protein p BA201_09810 ENOG4108VXD carboxy-peptidase BA201_09820 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BA201_09840 ENOG4108ZRV stage ii sporulation protein p BA201_09850 ENOG4108X4Q Hydrolase BA201_09865 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BA201_09880 ENOG41087PP glycosyltransferase MGT family BA201_09885 ENOG4108JYZ YitT family BA201_09890 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BA201_09920 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BA201_09940 ENOG4106PAW secretion accessory protein EsaA YueB BA201_09950 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) BA201_09955 ENOG4108MGT Required for secretion of EsxA and EsxB BA201_10035 ENOG4108IPW abc transporter atp-binding protein BA201_10065 ENOG4108ZUE Phage regulatory protein rha BA201_10125 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BA201_10135 ENOG4105KBJ sporulation protein ytfj BA201_10160 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BA201_10180 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BA201_10185 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BA201_10195 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BA201_10200 ENOG4105EMN RNA polymerase sigma factor BA201_10210 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) BA201_10220 ENOG4105CNW domain protein BA201_10230 ENOG4108V06 Glutathione peroxidase BA201_10245 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BA201_10255 ENOG4108IUE nitrate reductase beta subunit BA201_10260 ENOG4105R3A Nitrate reductase BA201_10270 ENOG4107V6Q Cyclic nucleotide-binding domain BA201_10275 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BA201_10280 ENOG4105D06 uba thif-type nad fad binding protein BA201_10285 ENOG4105CVM Molybdenum cofactor synthesis domain protein BA201_10290 ENOG4108ZAF Molybdopterin BA201_10315 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BA201_10320 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BA201_10325 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BA201_10330 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BA201_10335 ENOG4108IFG nitrite reductase, (NAD(P)H) BA201_10340 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BA201_10375 ENOG4105MCT stage V sporulation protein S BA201_10420 ENOG4105C5H ABC transporter BA201_10435 ENOG4108UUM single-stranded DNA-binding protein BA201_10455 ENOG4107YX5 Pfam:DUF548 BA201_10460 ENOG4105C75 arginyL-tRNA synthetase BA201_10480 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BA201_10495 ENOG4105C5S asparaginyl-tRNA synthetase BA201_10500 ENOG4105C8J )-transporter BA201_10520 ENOG4107XGZ Hydrolase BA201_10525 ENOG4105CY2 Citrate transporter BA201_10545 ENOG4105KD7 acetyltransferase BA201_10555 ENOG4105VMP Transcriptional regulator BA201_10560 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BA201_10585 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 BA201_10600 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) BA201_10605 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BA201_10615 ENOG4107RVG penicillin-binding protein BA201_10620 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BA201_10625 ENOG4105E9Q Acyl-transferase BA201_10630 ENOG4108UT2 hemolysin iii BA201_10640 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BA201_10650 ENOG4108RCR degv family BA201_10660 ENOG4108KF3 Electron transport protein SCO1 SenC BA201_10665 ENOG4107Y70 Heat shock protein BA201_10670 ENOG4105CAQ asparagine synthetase BA201_10685 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BA201_10690 ENOG4108MES Periplasmic binding protein BA201_10695 ENOG4105F0I Aminotransferase BA201_10720 ENOG4105D8X mechanosensitive ion channel BA201_10725 ENOG4105BZU Histidine kinase BA201_10730 ENOG4105WH1 Two component transcriptional regulator luxr family BA201_10735 ENOG4106KNT transcriptional regulator BA201_10740 ENOG4107ZY0 Phenazine biosynthesis-like protein BA201_10760 ENOG4105CMG Carbohydrate kinase BA201_10765 ENOG4105C6Z Gluconate BA201_10775 ENOG4108YV3 Protein of unknown function (DUF2711) BA201_10805 ENOG4108IJ8 ABC transporter BA201_10810 ENOG4105E90 ABC transporter BA201_10845 ENOG4105C37 (CBS) domain BA201_10870 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BA201_10885 ENOG4107S4Y M20 DapE family protein YgeY BA201_10890 ENOG4108TSC N-acetyltransferase BA201_10895 ENOG4108JUB Transcriptional regulator BA201_10900 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BA201_10945 ENOG410841Q phosphoesterase PA-phosphatase related protein BA201_10955 ENOG4105SZ6 Thioredoxin BA201_10995 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BA201_11050 ENOG4105BZ4 penicillin-binding protein BA201_11060 ENOG4105CZM Major Facilitator BA201_11065 ENOG4105W8X HesB YadR YfhF-family protein BA201_11075 ENOG4105DXD 2-methylcitrate dehydratase BA201_11080 ENOG4105CR4 methylisocitrate lyase BA201_11085 ENOG4105C1G acyl-Coa dehydrogenase BA201_11090 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BA201_11100 ENOG4105N14 lysine exporter protein LysE YggA BA201_11105 ENOG4105E39 Enoyl-CoA hydratase BA201_11120 ENOG4107RFY SbcCD D subunit BA201_11125 ENOG4105EYH Exonuclease BA201_11130 ENOG4105VTR Integrase BA201_11210 ENOG4105C2M dna polymerase I BA201_11230 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) BA201_11235 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) BA201_11260 ENOG4105DVF Cytosine-specific methyltransferase BA201_11410 ENOG410907Z n-acetylmuramoyl-l-alanine amidase BA201_11420 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BA201_11480 ENOG4105FCD Major Facilitator BA201_11485 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BA201_11490 ENOG4105E4F Isochorismate synthase BA201_11495 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BA201_11500 ENOG4105WQI isochorismatase BA201_11505 ENOG4105CEY Amp-dependent synthetase and ligase BA201_11510 ENOG4105WQT MbtH domain protein BA201_11515 ENOG4105C0R drug resistance transporter emrb qaca subfamily BA201_11530 ENOG4105K70 DNA-binding protein BA201_11550 ENOG4105BZG amino acid carrier protein BA201_11570 ENOG4105FE9 pseudouridine synthase BA201_11575 ENOG4105C22 threonyL-tRNA synthetase BA201_11580 ENOG4105C19 ABC transporter BA201_11635 ENOG41081I9 integral membrane protein BA201_11645 ENOG4108Y4K DNA-binding transcriptional activator BA201_11665 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BA201_11675 ENOG4105EYF MMPL domain protein BA201_11705 ENOG4105WCN acetyltransferase BA201_11730 ENOG4105C1Q protoporphyrinogen oxidase BA201_11740 ENOG41068WN BA201_11770 ENOG4107V2S Transcriptional regulator BA201_11775 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BA201_11795 ENOG4105DND Transcriptional regulator BA201_11800 ENOG4108RPX mosc domain containing protein BA201_11815 ENOG4105BZ1 (ABC) transporter BA201_11820 ENOG4105BZ1 (ABC) transporter BA201_11850 ENOG4108JCI Transcriptional regulator BA201_11880 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) BA201_11885 ENOG4108KPJ rna polymerase sigma factor BA201_11910 ENOG4105F32 YngK protein BA201_11930 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) BA201_11935 ENOG4105RD7 BadF BadG BcrA BcrD BA201_11940 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BA201_11945 ENOG4107STF Involved in phosphonate degradation (By similarity) BA201_11950 ENOG4105C7B Threonine dehydratase BA201_11955 ENOG4108INS Transcriptional regulator BA201_11975 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BA201_11985 ENOG4105C1J atp-dependent rna helicase BA201_11995 ENOG4108RZE Tetr family transcriptional regulator BA201_12090 ENOG41088CC tellurite resistance protein tehB BA201_12105 ENOG4107RA9 decarboxylase BA201_12110 ENOG4105K56 Transcriptional regulator BA201_12115 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BA201_12140 ENOG4105CIN aminoacyl-histidine dipeptidase BA201_12165 ENOG4105KRN Transcriptional regulator, abrb family BA201_12175 ENOG4105EJ9 Membrane BA201_12180 ENOG4105EQK -acetyltransferase BA201_12285 ENOG4108IG5 Transcriptional regulator BA201_12310 ENOG4105ED2 Beta-lactamase BA201_12320 ENOG4105FQP Beta-lactamase BA201_12325 ENOG4107RVG penicillin-binding protein BA201_12340 ENOG4107RF6 penicillin-binding protein BA201_12345 ENOG4107RF6 penicillin-binding protein BA201_12355 ENOG4105DIN metallophosphoesterase BA201_12365 ENOG4105CJ1 ABC, transporter BA201_12375 ENOG4107Z3H Transcriptional regulator, TetR family BA201_12390 ENOG4105C1G acyl-Coa dehydrogenase BA201_12395 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BA201_12400 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BA201_12405 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BA201_12410 ENOG4105E39 Enoyl-CoA hydratase BA201_12415 ENOG4107QX3 carboxylase BA201_12420 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BA201_12440 ENOG4105DBI uridine monophosphokinase BA201_12455 ENOG4105DZ1 carboxypeptidase BA201_12470 ENOG4105T9C HD domain BA201_12480 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BA201_12500 ENOG41075H3 AraC family transcriptional regulator BA201_12530 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BA201_12560 ENOG4105MDS 4-oxalocrotonate tautomerase BA201_12565 ENOG4107V2S Transcriptional regulator BA201_12595 ENOG4105EFA 4-hydroxyphenylacetate BA201_12610 ENOG4105CPQ Dehydrogenase BA201_12620 ENOG410900G Protein of unknown function (DUF421) BA201_12625 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BA201_12635 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein BA201_12645 ENOG4105DK7 lysyl-tRNA synthetase BA201_12655 ENOG4108VQT Alpha beta hydrolase fold protein BA201_12715 ENOG4105D6E homoserine dehydrogenase BA201_12725 ENOG4105CPF Cell wall formation (By similarity) BA201_12730 ENOG4105ETU transcriptional activator (TenA BA201_12820 ENOG410667J hydrolase BA201_12825 ENOG4105BZU Histidine kinase BA201_12830 ENOG4107RF6 penicillin-binding protein BA201_12855 ENOG4108FPN Integrase BA201_12875 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BA201_12890 ENOG41086D8 Transcriptional regulator BA201_12925 ENOG4108NHD germination protein BA201_12935 ENOG4108W2Y isochorismatase BA201_12950 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BA201_12960 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BA201_13005 ENOG4108JJB ABC transporter BA201_13015 ENOG4108HGU Histidine kinase BA201_13030 ENOG4105CB2 alcohol dehydrogenase BA201_13035 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BA201_13040 ENOG4105CJN penicillin-binding protein BA201_13095 ENOG4107Y80 Major Facilitator superfamily BA201_13110 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BA201_13135 ENOG4107Y9U Membrane BA201_13180 ENOG4105FCD Major Facilitator BA201_13195 ENOG4105E09 nadh pyrophosphatase BA201_13200 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BA201_13220 ENOG4105KME endoribonuclease L-psp BA201_13225 ENOG4108XI2 Domain of unknown function (DUF1963) BA201_13250 ENOG4108NRW Phospholipase, patatin family BA201_13255 ENOG4105KWG Pfam:DUF1696 BA201_13265 ENOG4108YYS metal-dependent hydrolase (By similarity) BA201_13280 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BA201_13290 ENOG4105PKS Excinuclease abc c subunit domain protein BA201_13320 ENOG4105CJ1 ABC, transporter BA201_13340 ENOG4107VFR oxidoreductase BA201_13375 ENOG4105U0R haloacid dehalogenase-like hydrolase BA201_13395 ENOG4108IUM Glycogen debranching enzyme BA201_13405 ENOG4105CGH 5'-nucleotidase BA201_13420 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BA201_13425 ENOG4105FDR Membrane BA201_13435 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BA201_13480 ENOG4105MSI germination protein ypeb BA201_13510 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) BA201_13515 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) BA201_13520 ENOG4107Z3H Transcriptional regulator, TetR family BA201_13545 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BA201_13560 ENOG4105E98 transcriptional regulator DeoR family BA201_13575 ENOG41062ES Transcriptional regulator BA201_13595 ENOG4107QKR Dehydrogenase BA201_13605 ENOG4107RUY (E1 component), alpha subunit BA201_13615 ENOG4105E1F short-chain dehydrogenase reductase BA201_13645 ENOG4107SQ8 Glycine betaine BA201_13650 ENOG4108IJ7 Glycine betaine BA201_13660 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BA201_13675 ENOG4105E66 phosphoriboisomerase A BA201_13680 ENOG41082BV acetyltransferase BA201_13685 ENOG4108M1A Chitin-binding protein BA201_13695 ENOG4105E6M Sulphatase-modifying factor protein BA201_13715 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BA201_13720 ENOG4105MSB protein, conserved in bacteria BA201_13740 ENOG4108Z7F N-acetyltransferase BA201_13760 ENOG4105EEM helicase BA201_13775 ENOG4105DQ6 Transposase BA201_13790 ENOG4105C9U ATP-dependent DNA helicase RecQ BA201_13835 ENOG4108M1A Chitin-binding protein BA201_13855 ENOG4105BZG amino acid carrier protein BA201_13860 ENOG4105C26 Dehydrogenase BA201_13865 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BA201_13870 ENOG4105CTU Proline racemase BA201_13875 ENOG4105CTU Proline racemase BA201_13880 ENOG41080HI glycine oxidase BA201_13890 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein BA201_13920 ENOG4105DCI Phosphohydrolase BA201_13925 ENOG4107T5V SNARE associated Golgi BA201_13935 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BA201_13955 ENOG4105DTQ mandelate racemase muconate lactonizing BA201_13970 ENOG4107SET aldo keto reductase BA201_14005 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BA201_14010 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BA201_14015 ENOG4105BZU Histidine kinase BA201_14020 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BA201_14045 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 BA201_14060 ENOG4105DPN Oligoendopeptidase f BA201_14065 ENOG4105EPR degv family BA201_14125 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BA201_14130 ENOG4106K7D Major facilitator family transporter BA201_14150 ENOG4107BMA Transglycosylase associated protein BA201_14165 ENOG41089UC methyltransferase, type 11 BA201_14200 ENOG4105CHM Aminotransferase BA201_14215 ENOG4108ZMI UPF0477 protein BA201_14255 ENOG4105C02 permease BA201_14265 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BA201_14270 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BA201_14275 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BA201_14280 ENOG4105D7T ABC transporter BA201_14315 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BA201_14350 ENOG4107VC0 DNA alkylation repair enzyme BA201_14355 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BA201_14365 ENOG4107VMI polysaccharide deacetylase BA201_14375 ENOG4108ZCF integral membrane protein BA201_14380 ENOG4105E0M Sulfatase BA201_14385 ENOG4105C5H ABC transporter BA201_14465 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BA201_14475 ENOG4105EYF MMPL domain protein BA201_14480 ENOG41082JN Transcriptional regulator BA201_14500 ENOG4105CIH Imidazole acetol-phosphate transaminase BA201_14505 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BA201_14510 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BA201_14555 ENOG41069ER domain protein BA201_14565 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BA201_14570 ENOG4105DNP FAD linked oxidase domain protein BA201_14595 ENOG4105D4B ABC, transporter BA201_14600 ENOG4105F5R ABC transporter BA201_14605 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane BA201_14615 ENOG4105DKT Transcriptional regulator BA201_14620 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) BA201_14630 ENOG41061GT Aldolase BA201_14645 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BA201_14680 ENOG4105II7 pyrroline-5-carboxylate reductase BA201_14690 ENOG4107258 Transcriptional regulator BA201_14705 ENOG4105ECK Fatty Acid Desaturase BA201_14715 ENOG4107RBI VanW family BA201_14720 ENOG4105G6Z alkaline phosphatase BA201_14730 ENOG4105VMP Transcriptional regulator BA201_14750 ENOG41068WN BA201_14775 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BA201_14800 ENOG4105CKK Glycosyl transferase, family 2 BA201_14835 ENOG4105C8Y Acetylornithine aminotransferase BA201_14880 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BA201_14955 ENOG4108IBT Inherit from COG: transposase BA201_14975 ENOG4108TVJ Nitroreductase BA201_14980 ENOG4105FS7 Transcriptional regulator BA201_14995 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BA201_15000 ENOG4105WEC Molybdate metabolism regulator BA201_15005 ENOG4105CMR udp-glucose 4-epimerase BA201_15010 ENOG4105C19 ABC transporter BA201_15035 ENOG4108DMH HTH_ARAC BA201_15040 ENOG4108XET gCN5-related N-acetyltransferase BA201_15115 ENOG410635A Membrane BA201_15125 ENOG4108IQI permease BA201_15135 ENOG4105F1N DNA alkylation repair BA201_15170 ENOG4107RF6 penicillin-binding protein BA201_15200 ENOG4105E7W lamb ycsf family protein BA201_15210 ENOG4105P4J Allophanate hydrolase, subunit 1 BA201_15215 ENOG4107258 Transcriptional regulator BA201_15225 ENOG4106N3A copper homeostasis protein cutc BA201_15230 ENOG4108ZHR arsR family transcriptional regulator BA201_15240 ENOG4105FDT acyl-CoA dehydrogenase BA201_15255 ENOG4105DWD nucleoside recognition domain protein BA201_15300 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BA201_15325 ENOG4105E2A Dehydrogenase BA201_15335 ENOG4108IJ0 Aspartate ammonia-lyase BA201_15340 ENOG4105HDK L-asparaginase BA201_15345 ENOG4108IMY Transcriptional regulator BA201_15355 ENOG4108B31 Spore germination protein BA201_15365 ENOG4105BZU Histidine kinase BA201_15390 ENOG41075H3 AraC family transcriptional regulator BA201_15395 ENOG4105YWU small acid-soluble spore protein BA201_15400 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BA201_15405 ENOG4105CUB amino acid BA201_15410 ENOG4105II7 pyrroline-5-carboxylate reductase BA201_15415 ENOG4108NHD germination protein BA201_15420 ENOG4108Q8B Spore germination protein BA201_15480 ENOG4105CGH 5'-nucleotidase BA201_15490 ENOG4105CHJ isochorismatase hydrolase BA201_15515 ENOG41090MY MarR family Transcriptional regulator BA201_15540 ENOG4105F6J Alpha beta hydrolase fold BA201_15560 ENOG4105CVP deoxyribo-dipyrimidine photolyase BA201_15585 ENOG4108TWJ NADH dehydrogenase subunit 5 BA201_15590 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BA201_15595 ENOG4107VMI polysaccharide deacetylase BA201_15600 ENOG4105KY5 gCN5-related N-acetyltransferase BA201_15605 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BA201_15630 ENOG4105Z7P Acetyltransferase (GNAT) family BA201_15640 ENOG4105D6J arsenicaL-resistance protein BA201_15645 ENOG41085FC arsR family transcriptional regulator BA201_15655 ENOG4105NAE bifunctional deaminase-reductase domain protein BA201_15660 ENOG4107P5I polyketide synthase BA201_15665 ENOG4108IG5 Transcriptional regulator BA201_15670 ENOG4105CHR reductase BA201_15675 ENOG4108YXU transcriptional regulator AsnC family BA201_15690 ENOG4105D7V transposase BA201_15825 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BA201_15830 ENOG4105C0R drug resistance transporter emrb qaca subfamily BA201_15850 ENOG4105K6H D-cysteine desulfhydrase BA201_15860 ENOG4105E0Y RtcB Protein BA201_15870 ENOG4105JQZ Methyltransferase BA201_15885 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BA201_15905 ENOG4105BZU Histidine kinase BA201_15915 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BA201_15940 ENOG4108JQ1 Dehydrogenase BA201_15945 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BA201_15960 ENOG41082W1 Cupin 2, conserved barrel domain protein BA201_15965 ENOG410874W AraC family transcriptional regulator BA201_15985 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BA201_16195 ENOG4108VXD carboxy-peptidase BA201_16200 ENOG4105PNM synthesis protein BA201_16210 ENOG4108ISG Major Facilitator BA201_16225 ENOG4107MII Sugar-specific transcriptional regulator TrmB BA201_16230 ENOG4105CZM Major Facilitator BA201_16240 ENOG4105CRW Short chain fatty acid transporter BA201_16250 ENOG4105DYS nad(p)h dehydrogenase (quinone) BA201_16310 ENOG4108K8S endonuclease I BA201_16335 ENOG4108Z66 YbaK ebsC protein BA201_16340 ENOG4105CUT histidyl-tRNA synthetase BA201_16355 ENOG4105KVH Transcriptional regulator BA201_16360 ENOG4108RCM Nitroreductase BA201_16390 ENOG4108PSK reductase BA201_16460 ENOG4105C31 Tryptophanyl-tRNA synthetase BA201_16465 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BA201_16525 ENOG4105C37 (CBS) domain BA201_16540 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase BA201_16545 ENOG4105FAW cDP-glucose 4,6-dehydratase BA201_16580 ENOG4105DDN Pentapeptide repeat-containing protein BA201_16585 ENOG4105XDF Protein of unknown function (DUF1272) BA201_16590 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BA201_16595 ENOG4105CMG Carbohydrate kinase BA201_16600 ENOG4105C6Z Gluconate BA201_16615 ENOG4105CV1 Transketolase (EC 2.2.1.1) BA201_16620 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BA201_16625 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BA201_16635 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BA201_16650 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BA201_16665 ENOG4105C8Q Methyl-accepting chemotaxis BA201_16670 ENOG4108UX3 '-nucleotidase BA201_16675 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BA201_16680 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BA201_16685 ENOG4105KVH Transcriptional regulator BA201_16700 ENOG4105CV8 reductase BA201_16705 ENOG4105F27 Major Facilitator BA201_16715 ENOG41090KN UPF0303 protein BA201_16725 ENOG4105C44 Serine transporter BA201_16755 ENOG4105KVH Transcriptional regulator BA201_16760 ENOG4108TZY GntR Family Transcriptional Regulator BA201_16765 ENOG4105D9R oxidoreductase BA201_16770 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BA201_16775 ENOG4105KVH Transcriptional regulator BA201_16780 ENOG4105KVH Transcriptional regulator BA201_16820 ENOG4105JAB phenazine biosynthesis protein, phzf family BA201_16830 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BA201_16835 ENOG4105KVH Transcriptional regulator BA201_16850 ENOG4105DQ6 Transposase BA201_16855 ENOG4108ZJ4 polysaccharide deacetylase BA201_16940 ENOG4107YXZ hydrolase, family 25 BA201_16970 ENOG4105H3G oxidoreductase BA201_17035 ENOG4108TN2 lmbE family BA201_17045 ENOG4107R3E Citrate transporter BA201_17060 ENOG4108MES Periplasmic binding protein BA201_17065 ENOG4105EHG Permease protein BA201_17070 ENOG4105DQ5 transport system permease protein BA201_17075 ENOG4105NX3 Membrane BA201_17095 ENOG4107CUJ Protein of unknown function (DUF2690) BA201_17105 ENOG4107V2S Transcriptional regulator BA201_17125 ENOG4105C98 muts2 protein BA201_17135 ENOG4105E5K Alpha-amylase BA201_17140 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BA201_17145 ENOG4105DPN Oligoendopeptidase f BA201_17150 ENOG4108A04 Beta-lactamase BA201_17175 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BA201_17185 ENOG41082BM Transcriptional regulator, arsr family BA201_17190 ENOG4105CIS alcohol dehydrogenase BA201_17195 ENOG4105CNG UPF0061 protein BA201_17225 ENOG4105CQB FAD linked oxidase domain protein BA201_17250 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BA201_17260 ENOG4107TPS domain protein BA201_17265 ENOG4105CEP NADH dehydrogenase BA201_17275 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase BA201_17285 ENOG4108IAJ Nad-dependent epimerase dehydratase BA201_17290 ENOG4105FAW cDP-glucose 4,6-dehydratase BA201_17340 ENOG4105BZU Histidine kinase BA201_17345 ENOG4105C5H ABC transporter BA201_17355 ENOG4107DUR UPF0457 protein BA201_17375 ENOG4105BZU Histidine kinase BA201_17385 ENOG4105KT7 mgtC SapB transporter BA201_17395 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BA201_17400 ENOG41073R8 VanW family BA201_17410 ENOG4108R1P BA201_17425 ENOG4105VEQ Cold shock protein BA201_17445 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BA201_17465 ENOG410904N short-chain dehydrogenase reductase BA201_17475 ENOG4106IQC argininosuccinate lyase BA201_17490 ENOG4108IA2 Sodium pantothenate symporter BA201_17500 ENOG4105C26 Dehydrogenase BA201_17505 ENOG4105CHR reductase BA201_17515 ENOG4105EWU Squalene--hopene cyclase BA201_17525 ENOG4105FR1 rard protein BA201_17530 ENOG410696E Membrane BA201_17545 ENOG4105D1F ATP-binding protein BA201_17555 ENOG4108ZAF Molybdopterin BA201_17560 ENOG4105CVM Molybdenum cofactor synthesis domain protein BA201_17565 ENOG4105D06 uba thif-type nad fad binding protein BA201_17570 ENOG4105TMB Formate nitrite transporter BA201_17580 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BA201_17585 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BA201_17595 ENOG4108JB9 formate dehydrogenase BA201_17600 ENOG4105E1K spore germination protein BA201_17615 ENOG4105CUB amino acid BA201_17670 ENOG4107QJT sodium dicarboxylate symporter BA201_17675 ENOG4108KGH TRANSCRIPTIONal BA201_17685 ENOG4105EMN RNA polymerase sigma factor BA201_17695 ENOG4105CIG ABC transporter BA201_17705 ENOG4105D9R oxidoreductase BA201_17715 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BA201_17720 ENOG4105K4P CoA-binding domain protein BA201_17725 ENOG4105C0H protease BA201_17730 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BA201_17740 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BA201_17745 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BA201_17750 ENOG4105W8X HesB YadR YfhF-family protein BA201_17760 ENOG4105D7V transposase BA201_17785 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BA201_17790 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BA201_17800 ENOG4108JJ8 (ABC) transporter BA201_17805 ENOG4108I0Z Aconitate hydratase BA201_17835 ENOG4105E5W Transporter BA201_17845 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BA201_17865 ENOG4107F3J Amp-dependent synthetase and ligase BA201_17870 ENOG4107ZYJ bioY protein BA201_17875 ENOG4105CEY Amp-dependent synthetase and ligase BA201_17880 ENOG4108IMY Transcriptional regulator BA201_17920 ENOG4107AYK membrAne BA201_17930 ENOG4105BZU Histidine kinase BA201_17935 ENOG4105FBA Phospholipase Carboxylesterase BA201_17940 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BA201_17945 ENOG4105CK7 Sodium proline symporter BA201_17950 ENOG4105CBC glutamate synthase BA201_17955 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BA201_17960 ENOG4108VJ1 Transcriptional regulator (CarD family BA201_17965 ENOG4108903 Formimidoylglutamase BA201_18020 ENOG4107QIV Cytochrome c biogenesis protein BA201_18030 ENOG4105CH2 amidohydrolase BA201_18040 ENOG4105CJ1 ABC, transporter BA201_18055 ENOG4107RSM transcriptional regulator BA201_18060 ENOG4105VAW lrga family BA201_18065 ENOG41067MG lrgb family BA201_18105 ENOG4105BZ1 (ABC) transporter BA201_18110 ENOG4105BZ1 (ABC) transporter BA201_18130 ENOG4105T6C Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps BA201_18190 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BA201_18225 ENOG4108HW3 (ABC) transporter BA201_18230 ENOG4105CGH 5'-nucleotidase BA201_18240 ENOG4108SVB resolvase BA201_18260 ENOG4105K7K Transcriptional regulator BA201_18265 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BA201_18285 ENOG4105E4C Lytic transglycosylase catalytic BA201_18290 ENOG41065S2 pneumococcal vaccine antigen BA201_18320 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BA201_18325 ENOG4105C5F glutamine synthetase BA201_18330 ENOG4105KV4 Transcriptional regulator BA201_18335 ENOG4105CXI aluminum resistance protein BA201_18340 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BA201_18345 ENOG4105EN6 Membrane BA201_18355 ENOG4106F1P AAA ATPase, central domain protein BA201_18385 ENOG41069ER domain protein BA201_18390 ENOG4105DQ6 Transposase BA201_18400 ENOG4105DM4 PTS System BA201_18405 ENOG4105DE4 1-phosphofructokinase BA201_18410 ENOG4105E98 transcriptional regulator DeoR family BA201_18415 ENOG4107QW4 alcohol dehydrogenase BA201_18420 ENOG4108SJC Membrane BA201_18435 ENOG4105C85 amino acid BA201_18450 ENOG4105TMB Formate nitrite transporter BA201_18455 ENOG4105K70 DNA-binding protein BA201_18465 ENOG4105C59 p-type ATPase BA201_18470 ENOG410681U heavy metal transport detoxification protein BA201_18475 ENOG4105VPX protein, conserved in bacteria BA201_18485 ENOG4105NIV Esterase BA201_18490 ENOG4105E0A ABC, transporter BA201_18510 ENOG4105CGK Exodeoxyribonuclease III BA201_18520 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BA201_18525 ENOG4105D03 DNA-3-methyladenine glycosylase II BA201_18530 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BA201_18550 ENOG4105BZU Histidine kinase BA201_18585 ENOG41067MG lrgb family BA201_18605 ENOG4108S3Y transcriptional regulator BA201_18610 ENOG4105CS2 ec 3.2.1.21 BA201_18625 ENOG4105F0V Cell wall hydrolase BA201_18635 ENOG4105E0M Sulfatase BA201_18640 ENOG410890F Dynamin family BA201_18660 ENOG4105C4R Atp-dependent dna helicase BA201_18765 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BA201_18770 ENOG4105DQU oxidoreductase, subunit beta BA201_18775 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BA201_18780 ENOG4108IGT Dipeptidase BA201_18785 ENOG4105MCT stage V sporulation protein S BA201_18790 ENOG4105D48 metallophosphoesterase BA201_18805 ENOG4105CEV competence damage-inducible protein BA201_18810 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BA201_18825 ENOG4105XZV Protein of unknown function (DUF3243) BA201_18830 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BA201_18850 ENOG4105UIB (ABC) transporter BA201_18855 ENOG4108JQ9 ABC transporter BA201_18860 ENOG4105DIH basic membrane BA201_18865 ENOG4105FDP GntR family transcriptional regulator BA201_18870 ENOG4107QZI cell division protein FtsK BA201_18880 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BA201_18890 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BA201_18900 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BA201_18905 ENOG4108S0H Dipicolinic acid synthetase, b subunit BA201_18910 ENOG4105E35 Dipicolinate synthase subunit A BA201_18940 ENOG4105DTN riboflavin biosynthesis protein ribF BA201_18955 ENOG4105W7A Protein of unknown function (DUF503) BA201_18965 ENOG4105VHM ribosomal protein BA201_18970 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BA201_18975 ENOG4105CHV Transcription elongation factor NusA BA201_18985 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BA201_18990 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BA201_18995 ENOG4105DZP Membrane-associated zinc metalloprotease BA201_19000 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BA201_19005 ENOG4105KNE Phosphatidate cytidylyltransferase BA201_19010 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BA201_19020 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BA201_19050 ENOG4108HE4 integrase family BA201_19060 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BA201_19065 ENOG4105C79 DNA protecting protein DprA BA201_19070 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BA201_19085 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BA201_19110 ENOG4105VB6 UPF0109 protein BA201_19130 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BA201_19135 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BA201_19150 ENOG4105CHR reductase BA201_19155 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BA201_19170 ENOG4105CB5 ATP-dependent DNA helicase recG BA201_19175 ENOG4105DP4 dak2 domain fusion protein ylov BA201_19180 ENOG4108ZAA Alkaline-shock protein BA201_19195 ENOG4105FJ0 thiamine BA201_19200 ENOG4105DJV ribulose-phosphate 3-epimerase BA201_19205 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BA201_19210 ENOG4105D9P serine threonine protein kinase BA201_19215 ENOG4108ZF3 Phosphatase BA201_19220 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BA201_19225 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BA201_19240 ENOG4105C25 Primosomal protein n' BA201_19245 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BA201_19265 ENOG4105DSJ YicC domain protein BA201_19275 ENOG4105F23 Fibronectin-binding protein BA201_19285 ENOG4105DC7 peptidase M24 BA201_19315 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BA201_19330 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) BA201_19335 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BA201_19345 ENOG4105CD3 dihydroorotase BA201_19365 ENOG4105C34 Pseudouridine synthase BA201_19380 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BA201_19390 ENOG4105DBK s4 domain protein BA201_19395 ENOG41067XK integral membrane protein BA201_19405 ENOG4105DFA alanine racemase domain protein BA201_19410 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BA201_19415 ENOG4105WR5 sporulation protein, YlmC YmxH family BA201_19425 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BA201_19435 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BA201_19440 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BA201_19450 ENOG4105D4A Cell wall formation (By similarity) BA201_19455 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BA201_19460 ENOG4105CNI cell division protein FtsW BA201_19465 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) BA201_19475 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BA201_19480 ENOG4105CJN penicillin-binding protein BA201_19485 ENOG4105CJN penicillin-binding protein BA201_19500 ENOG41074B2 UPF0747 protein BA201_19525 ENOG4105KNH Nucleic acid-binding protein BA201_19535 ENOG41063PX domain protein BA201_19540 ENOG4105D78 K07001 NTE family protein BA201_19545 ENOG4105H20 Sporulation integral membrane protein YlbJ BA201_19555 ENOG4106H78 methyltransferase BA201_19575 ENOG4107TB6 phosphoglycerate mutase BA201_19590 ENOG4106UY4 Inherit from COG: Scp-like extracellular BA201_19605 ENOG4105EKQ RNA-directed DNA polymerase BA201_19645 ENOG4107VFP cytochrome oxidase assembly BA201_19650 ENOG4105DQ6 Transposase BA201_19660 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BA201_19665 ENOG4105CNI cell division protein FtsW BA201_19680 ENOG4108IAB Phoh family BA201_19700 ENOG4105QA2 BA201_19705 ENOG4105CI3 gtp-binding protein typa BA201_19715 ENOG4105ECY inositol monophosphatase BA201_19735 ENOG4105CXN decarboxylase BA201_19785 ENOG4105CPP Dehydrogenase, E1 component BA201_19800 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BA201_19805 ENOG4108X4Q Hydrolase BA201_19815 ENOG4105CN5 Metallo-Beta-Lactamase BA201_19820 ENOG4107ZYR domain protein BA201_19855 ENOG4108XRC Protein of unknown function (DUF458) BA201_19865 ENOG4107IN1 Protein of unknown function (DUF1797) BA201_19880 ENOG4105EPM Diguanylate phosphodiesterase BA201_19885 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BA201_19900 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BA201_19910 ENOG4105UIN BA201_19945 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BA201_19955 ENOG4105EKQ RNA-directed DNA polymerase BA201_19970 ENOG4108HGU Histidine kinase BA201_19980 ENOG4105CHM Aminotransferase BA201_19985 ENOG4105FKQ transcriptional regulator BA201_19990 ENOG4105EG2 ABC transporter, permease BA201_20000 ENOG4107FKK extracellular solute-binding protein family 1 BA201_20010 ENOG4105CG3 alpha amylase, catalytic region BA201_20055 ENOG4105CHU acetyl-coa acetyltransferase BA201_20085 ENOG4105K7K Transcriptional regulator BA201_20090 ENOG4105DTD Dehydrogenase BA201_20105 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BA201_20110 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BA201_20120 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate BA201_20135 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BA201_20150 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BA201_20160 ENOG4105BZU Histidine kinase BA201_20180 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BA201_20195 ENOG4105CID antiterminator BA201_20205 ENOG4105FDP GntR family transcriptional regulator BA201_20215 ENOG4105CE4 GlcNAc 6-P deacetylase BA201_20250 ENOG4107ZE5 PPIases accelerate the folding of proteins BA201_20255 ENOG4105PTM secreted protein BA201_20260 ENOG4105J7I hydrolase BA201_20270 ENOG4105G6R Stage v sporulation protein ae BA201_20280 ENOG4105CZ3 stage V sporulation protein ad BA201_20285 ENOG41090VF Stage v sporulation protein ac BA201_20305 ENOG4105C8J )-transporter BA201_20310 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BA201_20320 ENOG41082AN stage II sporulation protein BA201_20325 ENOG4105DZ1 carboxypeptidase BA201_20330 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BA201_20335 ENOG4105DVE abc transporter atp-binding protein BA201_20370 ENOG4105D7N magnesium and cobalt transport protein CorA BA201_20395 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BA201_20405 ENOG4105I3K Ferric uptake regulator, Fur family BA201_20410 ENOG4105MZ9 stage II sporulation protein m BA201_20430 ENOG4105CPC Aldo Keto reductase BA201_20440 ENOG4105RHY Pfam:UPF0157 BA201_20460 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BA201_20470 ENOG4105ETE Transcriptional regulator (LacI family BA201_20475 ENOG4108YM7 Gcn5-related n-acetyltransferase BA201_20495 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BA201_20500 ENOG4108R6K riboflavin synthase, subunit alpha BA201_20525 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BA201_20530 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BA201_20540 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) BA201_20545 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BA201_20555 ENOG4105DFD Na H antiporter BA201_20560 ENOG4105CGH 5'-nucleotidase BA201_20585 ENOG4105DBV ornithine carbamoyltransferase BA201_20600 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BA201_20615 ENOG4108IXY short-chain dehydrogenase reductase BA201_20620 ENOG41069FQ Metallo-beta-lactamase superfamily BA201_20625 ENOG4105II7 pyrroline-5-carboxylate reductase BA201_20630 ENOG4105EJQ L-serine dehydratase BA201_20640 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BA201_20660 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BA201_20665 ENOG4105D9U N-acetyltransferase BA201_20675 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BA201_20680 ENOG4108QEG Membrane BA201_20685 ENOG4105CDA abc transporter atp-binding protein BA201_20690 ENOG4105E5Q amino acid AbC transporter BA201_20695 ENOG4108HW3 (ABC) transporter BA201_20705 ENOG4105G7B Protein of unknown function (DUF2992) BA201_20715 ENOG4108QY0 Membrane BA201_20725 ENOG4105C7S Dehydrogenase BA201_20730 ENOG4105CPP Dehydrogenase, E1 component BA201_20745 ENOG4105CKM Branched-chain carboxylic acid kinase BA201_20750 ENOG4107RDP Dehydrogenase BA201_20760 ENOG4108JUB Transcriptional regulator BA201_20770 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BA201_20785 ENOG4107QQR Sporulation BA201_20790 ENOG4105S1Z Stage IV sporulation protein B BA201_20795 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BA201_20800 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BA201_20805 ENOG4105DX0 Hemolysin A BA201_20815 ENOG4105CTB Polyprenyl synthetase BA201_20830 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BA201_20840 ENOG4108ZSR alkaline shock protein BA201_20845 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BA201_20865 ENOG410644B Stage III sporulation protein af BA201_20875 ENOG4105KQ4 Stage iii sporulation protein ad BA201_20880 ENOG4108CQH stage III sporulation protein AC BA201_20885 ENOG4105KR5 Stage iii sporulation protein BA201_20890 ENOG4105CD2 stage iii sporulation protein aa BA201_20915 ENOG4105DC7 peptidase M24 BA201_20920 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BA201_20930 ENOG4105CBJ Metal-dependent enzyme BA201_20940 ENOG4107YBY Hydrolase BA201_20970 ENOG41082GG biotin lipoate A B protein ligase BA201_20975 ENOG4105WZW rhodanese family BA201_21000 ENOG41080TC multidrug resistance protein BA201_21040 ENOG4105C0D helicase BA201_21115 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BA201_21145 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BA201_21215 ENOG4107R6U sodium dicarboxylate symporter BA201_21250 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BA201_21255 ENOG4105C3R Methionine synthase BA201_21265 ENOG4105C28 cystathionine BA201_21270 ENOG4105C28 cystathionine BA201_21290 ENOG4105C5X domain protein BA201_21300 ENOG4105DKQ ROK family BA201_21310 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BA201_21325 ENOG4108UTW Plays a role in the regulation of phosphate uptake BA201_21330 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BA201_21335 ENOG4105C8U phosphate abc transporter BA201_21340 ENOG4105C8U phosphate abc transporter BA201_21345 ENOG4105EXS phosphate abc transporter BA201_21350 ENOG4107RF6 penicillin-binding protein BA201_21360 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BA201_21385 ENOG4105N80 Ferric uptake regulator, Fur family BA201_21395 ENOG4105FDK ABC transporter BA201_21400 ENOG4108JYZ YitT family BA201_21405 ENOG41069ZM Protein of unknown function (DUF2624) BA201_21430 ENOG4105EGD dinuclear metal center protein, YbgI family BA201_21445 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BA201_21450 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BA201_21475 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BA201_21480 ENOG4105KG3 cytidine deaminase BA201_21485 ENOG4107YR5 Diacylglycerol kinase BA201_21490 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BA201_21495 ENOG4105CTJ Metal Dependent Phosphohydrolase BA201_21500 ENOG4105C9A Phoh family BA201_21510 ENOG41068P3 sporulation protein YqfC BA201_21515 ENOG4105KTH gatB Yqey BA201_21525 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BA201_21530 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BA201_21560 ENOG4105CSA Coproporphyrinogen iii oxidase BA201_21565 ENOG4105KVH Transcriptional regulator BA201_21590 ENOG4105TQK DNA polymerase iii, delta' subunit BA201_21600 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BA201_21605 ENOG4108UK2 deaminase BA201_21610 ENOG4105KQC Competence protein BA201_21620 ENOG4105DXX methyltransferase BA201_21630 ENOG4108WF2 Metal Dependent Phosphohydrolase BA201_21640 ENOG410812S Rna-binding protein BA201_21650 ENOG4105CQW ribosome biogenesis GTPase YqeH BA201_21655 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BA201_21670 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BA201_21690 ENOG4108TVJ Nitroreductase BA201_21705 ENOG4105G6Z alkaline phosphatase BA201_21710 ENOG4105KEG ribosomal-protein-alanine acetyltransferase BA201_21715 ENOG4108MUZ hydrolase BA201_21750 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BA201_21755 ENOG4105MIR Phenylalanine 4-monooxygenase BA201_21765 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BA201_21805 ENOG4105S6R Iron-hydroxamate transporter permease subunit BA201_21810 ENOG4108V5C ABC transporter BA201_21820 ENOG4108EKI Dehydrogenase BA201_21825 ENOG4105C28 cystathionine BA201_21855 ENOG4107XRG penicillin-binding protein BA201_21865 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BA201_21875 ENOG4105CFP Peptidase U32 BA201_21880 ENOG4105XYU peptidase (U32 family) BA201_21885 ENOG4108VQJ O-methyltransferase BA201_21890 ENOG4105HHA aminodeoxychorismate lyase BA201_21910 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BA201_21920 ENOG4105C02 permease BA201_21935 ENOG41060CR BA201_21940 ENOG4105C7H Helicase, RecD TraA family BA201_21950 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BA201_21955 ENOG4105C3J Cysteine desulfurase BA201_21965 ENOG4105D1H recombination factor protein RarA BA201_21970 ENOG4108VCI transcription factor, rsfa family BA201_21975 ENOG4105CUZ uba thif-type nad fad binding protein BA201_21985 ENOG4105CUT histidyl-tRNA synthetase BA201_21995 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BA201_22000 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BA201_22010 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BA201_22015 ENOG41076HS cation diffusion facilitator family transporter BA201_22020 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BA201_22030 ENOG4105CKP Polysaccharide Biosynthesis Protein BA201_22035 ENOG4108QG2 Membrane BA201_22045 ENOG4105VIE preprotein translocase, subunit YajC BA201_22060 ENOG41061AI Protein of unknown function (DUF2905) BA201_22075 ENOG4108HUF Transporter BA201_22100 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) BA201_22105 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BA201_22110 ENOG4108IYU L-aspartate oxidase BA201_22125 ENOG4108RPX mosc domain containing protein BA201_22130 ENOG4105CQC Prephenate dehydratase BA201_22145 ENOG4105C19 ABC transporter BA201_22150 ENOG4105EWM Histidine kinase BA201_22160 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BA201_22175 ENOG4105X36 (ribosomal) protein BA201_22185 ENOG4105C03 ribonuclease BA201_22200 ENOG4107QMS site-determining protein BA201_22215 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BA201_22220 ENOG4105DFF Rod shape-determining protein mreb BA201_22440 ENOG4108C33 Resolvase BA201_22450 ENOG4108Z03 MAF-like protein BA201_22460 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BA201_22465 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BA201_22475 ENOG41068KH stage VI sporulation protein D BA201_22485 ENOG4105D52 delta-aminolevulinic acid dehydratase BA201_22510 ENOG4105K56 Transcriptional regulator BA201_22530 ENOG4108IUQ atp-dependent protease BA201_22550 ENOG4108QCI YvbH-like oligomerisation region BA201_22570 ENOG4105M59 Phosphodiesterase, mj0936 family BA201_22575 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BA201_22585 ENOG4108XJQ germination protein BA201_22595 ENOG4108PCX Major Facilitator BA201_22605 ENOG4105KBX Transcriptional regulator, TetR family BA201_22615 ENOG4105PFC Transcriptional regulator BA201_22625 ENOG4105DZC cytosine deaminase BA201_22630 ENOG41067S9 phage shock protein C, PspC BA201_22635 ENOG4108JCI Transcriptional regulator BA201_22645 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BA201_22650 ENOG4108Z40 Transcriptional regulator BA201_22655 ENOG4105RHA ABC transporter, permease BA201_22660 ENOG4108IUX (ABC) transporter BA201_22665 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BA201_22670 ENOG4105ER2 Ompa motb domain protein BA201_22675 ENOG4105E14 MotA TolQ exbB proton channel BA201_22680 ENOG4108VXD carboxy-peptidase BA201_22690 ENOG4105E33 succinate dehydrogenase BA201_22700 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BA201_22710 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BA201_22715 ENOG4105K63 Thioredoxin BA201_22720 ENOG4105C10 Electron transfer flavoprotein BA201_22725 ENOG4105BZJ Electron transfer flavoprotein BA201_22730 ENOG41060WC Enoyl-CoA hydratase BA201_22735 ENOG4107Z3H Transcriptional regulator, TetR family BA201_22740 ENOG4105CEY Amp-dependent synthetase and ligase BA201_22750 ENOG4105J76 Periplasmic binding protein BA201_22755 ENOG4105S6R Iron-hydroxamate transporter permease subunit BA201_22800 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BA201_22815 ENOG4105DR4 Methyltransferase BA201_22825 ENOG4105KFN sortase, SrtB family BA201_22830 ENOG4105E0A ABC, transporter BA201_22845 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BA201_22855 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BA201_22865 ENOG4105FE9 pseudouridine synthase BA201_22875 ENOG4105DCG PHP domain protein BA201_22890 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BA201_22910 ENOG4105C5S asparaginyl-tRNA synthetase BA201_22915 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BA201_22925 ENOG4108RWN rrna methyltransferase BA201_22955 ENOG4105C0R drug resistance transporter emrb qaca subfamily BA201_22960 ENOG4105CW7 secretion protein, HlyD family BA201_22965 ENOG4108JGH Tetr family transcriptional regulator BA201_22970 ENOG4105CN9 Peptidase m42 family protein BA201_22990 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BA201_22995 ENOG4105C22 threonyL-tRNA synthetase BA201_23000 ENOG4108TDW sporulation protein YtxC BA201_23010 ENOG4105DQ6 Transposase BA201_23035 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BA201_23040 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BA201_23045 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BA201_23055 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BA201_23060 ENOG4105C2M dna polymerase I BA201_23065 ENOG4105BZU Histidine kinase BA201_23070 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BA201_23085 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BA201_23090 ENOG4108HMX isocitrate dehydrogenase (NADP) BA201_23095 ENOG4105BZN citrate synthase BA201_23105 ENOG4108REF Sporulation integral membrane protein ytvi BA201_23110 ENOG4105FS0 cytoplasmic membrane protein BA201_23135 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BA201_23140 ENOG4105C6K Malic enzyme BA201_23145 ENOG4105C0B DNA polymerase III (alpha subunit) BA201_23150 ENOG4105VV2 BA201_23160 ENOG4105SFS phosphoesterase RecJ domain protein BA201_23185 ENOG4105E8R UPF0173 metal-dependent hydrolase BA201_23190 ENOG4105DC7 peptidase M24 BA201_23220 ENOG4105Z7P Acetyltransferase (GNAT) family BA201_23225 ENOG41082W1 Cupin 2, conserved barrel domain protein BA201_23245 ENOG4107YZX Universal stress protein BA201_23265 ENOG4105CH7 arginosuccinase BA201_23285 ENOG4108JYZ YitT family BA201_23305 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BA201_23315 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BA201_23320 ENOG4105KBJ sporulation protein ytfj BA201_23335 ENOG4105EFZ amidohydrolase BA201_23345 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BA201_23370 ENOG4105RQF LysR family Transcriptional regulator BA201_23380 ENOG4105U5Y Transcriptional regulator BA201_23390 ENOG4105C28 cystathionine BA201_23410 ENOG4108IBT Inherit from COG: transposase BA201_23465 ENOG4108UW5 maltose o-acetyltransferase BA201_23475 ENOG4105F1V Acetoin utilization protein BA201_23480 ENOG4105W87 Cbs domain BA201_23485 ENOG4105DGU Histone deacetylase BA201_23500 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BA201_23510 ENOG4107SNB ankyrin repeat protein YahD BA201_23515 ENOG4105EP9 oxidoreductase BA201_23535 ENOG4105ETE Transcriptional regulator (LacI family BA201_23540 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BA201_23560 ENOG4105C88 aminopeptidase BA201_23615 ENOG4108VDD TRNA binding domain protein BA201_23645 ENOG4105C8F Beta-lactamase domain protein BA201_23660 ENOG4108V15 phosphotransferase enzyme family BA201_23665 ENOG4108IUM Glycogen debranching enzyme BA201_23675 ENOG4107QSE Dipeptidase BA201_23680 ENOG4105YW5 deoR family transcriptional regulator BA201_23695 ENOG4105CBX hi0933 family BA201_23730 ENOG4108VJ1 Transcriptional regulator (CarD family BA201_23735 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BA201_23740 ENOG4105CSC Glucose uptake protein BA201_23755 ENOG4108ZAF Molybdopterin BA201_23760 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BA201_23765 ENOG4105CVM Molybdenum cofactor synthesis domain protein BA201_23775 ENOG4105D06 uba thif-type nad fad binding protein BA201_23780 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BA201_23800 ENOG41085GJ domain protein BA201_23810 ENOG4105DWV Homoserine O-trans-acetylase BA201_23820 ENOG4108B31 Spore germination protein BA201_23845 ENOG4105C8T Leucyl-tRNA synthetase BA201_23850 ENOG410605W Major Facilitator BA201_23855 ENOG4107S91 Sodium hydrogen exchanger BA201_23860 ENOG4105NCW Trka-c domain protein BA201_23875 ENOG4105C19 ABC transporter BA201_23895 ENOG4105N5T Radical SAM Protein BA201_23905 ENOG4105CIG ABC transporter BA201_23935 ENOG4105E8V Alpha Beta Hydrolase Fold protein BA201_23940 ENOG4108Z0R Transferase BA201_23945 ENOG4105YVM Phosphoesterase, PA-phosphatase related BA201_23950 ENOG4105BZF Glycosyl transferase (Group 1 BA201_23960 ENOG4105EPU Molybdenum cofactor synthesis domain protein BA201_23970 ENOG4108MK9 spermidine N(1)-acetyltransferase BA201_24015 ENOG4105BZU Histidine kinase BA201_24020 ENOG4105BZU Histidine kinase BA201_24035 ENOG4107S9D Alpha beta hydrolase BA201_24040 ENOG4107T7U Sulfatase BA201_24050 ENOG4105D2X ABC transporter substrate-binding protein BA201_24060 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BA201_24130 ENOG4108V2W Carbonate dehydratase BA201_24135 ENOG4105C4M (Ubiquinol oxidase) subunit I BA201_24140 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BA201_24180 ENOG41087YS Phage shock protein A BA201_24210 ENOG4105BZU Histidine kinase BA201_24215 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BA201_24240 ENOG4108UGV hypoxanthine phosphoribosyltransferase BA201_24245 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BA201_24290 ENOG4105C19 ABC transporter BA201_24300 ENOG4107ZTW SNARE associated Golgi BA201_24315 ENOG4105C19 ABC transporter BA201_24320 ENOG41086D8 Transcriptional regulator BA201_24330 ENOG41082BM Transcriptional regulator, arsr family BA201_24380 ENOG4105C6Z Gluconate BA201_24385 ENOG4105FDP GntR family transcriptional regulator BA201_24405 ENOG41069H0 dihydroorotase EC 3.5.2.3 BA201_24425 ENOG4105DTQ mandelate racemase muconate lactonizing BA201_24430 ENOG4105CEY Amp-dependent synthetase and ligase BA201_24435 ENOG4108IPT Naphthoate synthase BA201_24440 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BA201_24445 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BA201_24450 ENOG4105E4F Isochorismate synthase BA201_24455 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BA201_24465 ENOG4105VEQ Cold shock protein BA201_24500 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BA201_24505 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) BA201_24515 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BA201_24615 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BA201_24650 ENOG4105KT7 mgtC SapB transporter BA201_24655 ENOG4107PBV potassium channel BA201_24670 ENOG4105WG9 Conserved Protein BA201_24680 ENOG4105CHM Aminotransferase BA201_24685 ENOG4108ZB6 transcriptional regulator AsnC family BA201_24690 ENOG4105C5I Dehydrogenase BA201_24695 ENOG4108MUZ hydrolase BA201_24705 ENOG4105C87 Aminotransferase class I and II BA201_24720 ENOG4105Y38 Kinase-associated protein B BA201_24730 ENOG4107R3E Citrate transporter BA201_24745 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BA201_24750 ENOG4105KA0 thioesterase Superfamily protein BA201_24765 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BA201_24780 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BA201_24785 ENOG41069ER domain protein BA201_24800 ENOG4105CEP NADH dehydrogenase BA201_24830 ENOG4105EWC Purine nucleoside phosphorylase BA201_24845 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BA201_24870 ENOG4108JJA ABC, transporter BA201_24875 ENOG4105C4B ABC transporter, permease BA201_24880 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BA201_24930 ENOG41083MR nifu domain-containing protein BA201_24945 ENOG4108W5N phosphatidylglycerophosphatase a BA201_24965 ENOG4105DAX Pfam:DUF2983 BA201_24975 ENOG4105DYS nad(p)h dehydrogenase (quinone) BA201_24985 ENOG4105D4U had-superfamily hydrolase, subfamily iia BA201_25000 ENOG4105CBT Fructose-1,6-bisphosphatase BA201_25020 ENOG4105MMD transcriptional regulator BA201_25025 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BA201_25030 ENOG4107TXC Transcriptional regulator BA201_25035 ENOG41090T1 Membrane BA201_25060 ENOG4105FAA peptidase M23 BA201_25065 ENOG4108YTE sporulation protein YunB BA201_25070 ENOG4105KZD Domain of unknown function (DUF1805) BA201_25075 ENOG4107R8B 5'-nucleotidase BA201_25080 ENOG4105DIW FeS assembly protein SUFB BA201_25085 ENOG4108UNV SUF system FeS assembly protein, NifU family BA201_25090 ENOG4105C9B Cysteine desulfurase BA201_25095 ENOG4105JRK feS assembly protein SufD BA201_25100 ENOG4105C3K feS assembly ATPase SufC BA201_25105 ENOG4105D01 (LipO)protein BA201_25110 ENOG4105D01 (LipO)protein BA201_25115 ENOG4108UMI ABC transporter, permease BA201_25145 ENOG41080E8 Transcriptional regulator, Spx MgsR family BA201_25165 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BA201_25190 ENOG4108W8B Beta-lactamase domain protein BA201_25195 ENOG4105C1G acyl-Coa dehydrogenase BA201_25200 ENOG4105CHU acetyl-coa acetyltransferase BA201_25215 ENOG4105DZ1 carboxypeptidase BA201_25235 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BA201_25250 ENOG4108SUT Major Facilitator Superfamily BA201_25255 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) BA201_25265 ENOG4107R7I amino acid BA201_25285 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BA201_25295 ENOG4107AYK membrAne BA201_25330 ENOG4107ZTW SNARE associated Golgi BA201_25340 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BA201_25345 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BA201_25350 ENOG4105BZU Histidine kinase BA201_25365 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BA201_25390 ENOG4105C8Q Methyl-accepting chemotaxis BA201_25395 ENOG4105VG1 fes assembly suf system protein BA201_25400 ENOG4105D4Y metalloprotease BA201_25420 ENOG4107T5V SNARE associated Golgi BA201_25425 ENOG4107S91 Sodium hydrogen exchanger BA201_25430 ENOG4105NCW Trka-c domain protein BA201_25445 ENOG4108RMU ferritin dps family protein BA201_25460 ENOG4108URH decarboxylase BA201_25470 ENOG41090A1 ferritin BA201_25480 ENOG4105D9N nucleoside BA201_25485 ENOG4105D9N nucleoside BA201_25500 ENOG4108RYK Nad-dependent epimerase dehydratase BA201_25515 ENOG4105CV8 reductase BA201_25520 ENOG4105F27 Major Facilitator BA201_25525 ENOG4105KVH Transcriptional regulator BA201_25540 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BA201_25545 ENOG4105D4A Cell wall formation (By similarity) BA201_25565 ENOG4105WMR Protein CrcB homolog BA201_25570 ENOG4105WMR Protein CrcB homolog BA201_25580 ENOG4108MK9 spermidine N(1)-acetyltransferase BA201_25590 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BA201_25630 ENOG4108IPW abc transporter atp-binding protein BA201_25635 ENOG4105CM4 permease protein BA201_25655 ENOG4105EWM Histidine kinase BA201_25660 ENOG4105CJZ response regulator BA201_25665 ENOG4105C19 ABC transporter BA201_25690 ENOG4105C19 ABC transporter BA201_25750 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BA201_25760 ENOG4105XZU Preprotein translocase, subunit SecG BA201_25765 ENOG41067MG lrgb family BA201_25785 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BA201_25815 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BA201_25835 ENOG41090VF Stage v sporulation protein ac BA201_25840 ENOG4105CZ3 stage V sporulation protein ad BA201_25855 ENOG4108QY0 Membrane BA201_25860 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BA201_25865 ENOG4105KRI phosphocarrier protein (HPr BA201_25875 ENOG4105CHW UPF0052 protein BA201_25880 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BA201_25885 ENOG4108Z4K mutator MutT protein BA201_25895 ENOG4105C3M thioredoxin reductase BA201_25905 ENOG4108S4C acetyltransferase BA201_25915 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) BA201_25925 ENOG41086DT Membrane protein of unknown function BA201_25930 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BA201_25935 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BA201_25950 ENOG4107TXC Transcriptional regulator BA201_25965 ENOG4105HMI Membrane BA201_25970 ENOG4105DUM transcriptional regulator, lysR family BA201_25980 ENOG4108WS4 fmn reductase BA201_25995 ENOG4105BZ1 (ABC) transporter BA201_26005 ENOG4105CN1 protease BA201_26010 ENOG4105CRP Part of the ABC transporter FtsEX involved in BA201_26015 ENOG4105CAK Cell division ATP-binding protein ftsE BA201_26025 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BA201_26040 ENOG4108RDQ ABC transporter BA201_26070 ENOG4105MS2 ribosomal subunit Interface protein BA201_26075 ENOG4105VEQ Cold shock protein BA201_26080 ENOG41081UC Inherit from COG: Competence protein BA201_26090 ENOG4105K4H Nlp p60 protein BA201_26095 ENOG4105KVH Transcriptional regulator BA201_26105 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BA201_26110 ENOG4108KGH TRANSCRIPTIONal BA201_26115 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BA201_26120 ENOG4105C6Y Udp-glucose 6-dehydrogenase BA201_26125 ENOG4105ESV Glycosyl transferase, family 4 BA201_26135 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BA201_26155 ENOG4105F8D glycoside hydrolase family 4 BA201_26160 ENOG4105VCP PTS System BA201_26165 ENOG4105CK1 PTS System BA201_26175 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BA201_26180 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BA201_26185 ENOG4105VCP PTS System BA201_26195 ENOG4105VZJ PTS System BA201_26215 ENOG4105ECB domain protein BA201_26220 ENOG4107RSM transcriptional regulator BA201_26250 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) BA201_26255 ENOG4105DAA L-lactate BA201_26265 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) BA201_26275 ENOG4105E0M Sulfatase BA201_26300 ENOG4107R8N Glycosyl transferase, family 2 BA201_26310 ENOG4105C94 Transporter BA201_26315 ENOG41069ER domain protein BA201_26340 ENOG4105KBK Zinc finger, swim domain protein BA201_26345 ENOG4105C0D helicase BA201_26375 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BA201_26385 ENOG4107RBB ABC transporter, permease BA201_26390 ENOG4105C19 ABC transporter BA201_26400 ENOG4105CXY transporter BA201_26415 ENOG4105BZU Histidine kinase BA201_26420 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BA201_26425 ENOG4105DG6 mannose-6-phosphate isomerase BA201_26430 ENOG4105DM4 PTS System BA201_26450 ENOG4108KGH TRANSCRIPTIONal BA201_26455 ENOG4105DG6 mannose-6-phosphate isomerase BA201_26460 ENOG4105CJT Mannose-1-phosphate guanylyltransferase BA201_26470 ENOG4108TJN glycosyl transferase group 1 BA201_26475 ENOG4105C6Y Udp-glucose 6-dehydrogenase BA201_26505 ENOG4105D3Q Sugar transferase BA201_26510 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BA201_26515 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BA201_26520 ENOG4107YJ4 chain length determinant protein BA201_26525 ENOG4105HTX biosynthesis protein BA201_26530 ENOG4107YJ4 chain length determinant protein BA201_26545 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BA201_26555 ENOG4105FRN stage II sporulation protein BA201_26570 ENOG4105DY9 regulatoR BA201_26600 ENOG4106778 Protein of unknown function (DUF1146) BA201_26605 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BA201_26610 ENOG4105C8S subunit m BA201_26615 ENOG4105D65 subunit l BA201_26640 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BA201_26645 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BA201_26655 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BA201_26660 ENOG4105BZU Histidine kinase BA201_26710 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BA201_26715 ENOG41062M3 atp synthase BA201_26735 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BA201_26740 ENOG4108UIC UPF0340 protein BA201_26745 ENOG4108YZG isomerase BA201_26760 ENOG4108VGI doxx family BA201_26765 ENOG4107XC4 flavin reductase domain protein, FMN-binding BA201_26785 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BA201_26795 ENOG4108ZXQ stage ii sporulation protein r BA201_26800 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BA201_26805 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BA201_26810 ENOG4107104 thymidine kinase BA201_26820 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BA201_26825 ENOG4105CBT Fructose-1,6-bisphosphatase BA201_26830 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BA201_26850 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BA201_26865 ENOG4105C1G acyl-Coa dehydrogenase BA201_26870 ENOG4105C1G acyl-Coa dehydrogenase BA201_26875 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BA201_26885 ENOG4105DF6 Fe-S oxidoreductase BA201_26900 ENOG4105BZU Histidine kinase BA201_26915 ENOG4105D4Y metalloprotease BA201_26925 ENOG4105BZU Histidine kinase BA201_26930 ENOG4105KCT ABC transporter BA201_26935 ENOG4108M15 ABC transporter BA201_26940 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BA201_26950 ENOG4105IIU Aminopeptidase BA201_26970 ENOG4105DU6 RNA polymerase BA201_26980 ENOG410684U Domain of unknown function (DUF1934) BA201_27000 ENOG4105CYW agmatinase BA201_27010 ENOG4105DXB Major Facilitator superfamily BA201_27015 ENOG4107SWG transcriptional regulator MERR family BA201_27020 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BA201_27025 ENOG4105BZ4 penicillin-binding protein BA201_27030 ENOG4108XFG YwhD family BA201_27035 ENOG4108Z4T Peptidase M50 BA201_27040 ENOG41069HH 4-oxalocrotonate tautomerase BA201_27045 ENOG4105DCI Phosphohydrolase BA201_27050 ENOG4108MES Periplasmic binding protein BA201_27055 ENOG4105E0A ABC, transporter BA201_27060 ENOG4105EHG Permease protein BA201_27065 ENOG4105DQ5 transport system permease protein BA201_27075 ENOG4108VCI transcription factor, rsfa family BA201_27080 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) BA201_27085 ENOG4108IJ2 phosphate acetyltransferase BA201_27090 ENOG4107UEZ chlorite dismutase BA201_27100 ENOG4108VKI Cell wall hydrolase BA201_27120 ENOG4107SVH Potassium channel protein BA201_27130 ENOG410667J hydrolase BA201_27135 ENOG4105VCH membrane BA201_27145 ENOG4108TU7 Inherit from COG: (ABC) transporter BA201_27150 ENOG4105CJ1 ABC, transporter BA201_27155 ENOG41090WU lipolytic protein G-D-S-L family BA201_27170 ENOG4105D6E homoserine dehydrogenase BA201_27175 ENOG4105CVG Homoserine O-transsuccinylase BA201_27195 ENOG4108Y4K DNA-binding transcriptional activator BA201_27205 ENOG4105WH1 Two component transcriptional regulator luxr family BA201_27210 ENOG4105BZU Histidine kinase BA201_27215 ENOG4105DWF phosphomethylpyrimidine kinase BA201_27220 ENOG4105BZU Histidine kinase BA201_27225 ENOG4105VCD cytoplasmic protein BA201_27230 ENOG4105D22 carbon starvation protein BA201_27235 ENOG4105DY9 regulatoR BA201_27240 ENOG41079KZ Major Facilitator Superfamily BA201_27250 ENOG4105CG5 Glycosyl transferase (Group 1 BA201_27260 ENOG4105EN6 Membrane BA201_27265 ENOG4106YBV Methyl-accepting chemotaxis BA201_27275 ENOG4108S4H thioesterase Superfamily protein BA201_27280 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) BA201_27295 ENOG4105K64 Glycosyl transferase, family 2 BA201_27310 ENOG4105CKK Glycosyl transferase, family 2 BA201_27315 ENOG4105C5H ABC transporter BA201_27320 ENOG41067SE Tetr family transcriptional regulator BA201_27330 ENOG4105E0X reductase BA201_27335 ENOG4106F5Q Membrane BA201_27350 ENOG4108NEV two component transcriptional regulator, LytTR family BA201_27360 ENOG4107RGD Major Facilitator superfamily BA201_27375 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BA201_27385 ENOG4105IW1 AmiS UreI transporter BA201_27390 ENOG4105CMR udp-glucose 4-epimerase BA201_27395 ENOG4108UT2 hemolysin iii BA201_27405 ENOG4105C1J atp-dependent rna helicase BA201_27410 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) BA201_27415 ENOG4105DPN Oligoendopeptidase f BA201_27475 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) BA201_27485 ENOG4105C0H protease BA201_27490 ENOG4105Q2H domain protein BA201_27505 ENOG4105BZU Histidine kinase BA201_27510 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BA201_27535 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BA201_27540 ENOG4105CDU Replicative dna helicase BA201_27550 ENOG4105BZR domain protein BA201_27555 ENOG4108XMW Membrane BA201_27565 ENOG4108UUM single-stranded DNA-binding protein BA201_27575 ENOG4105C3G gtp-binding protein BA201_27580 ENOG4105VDK protein, conserved in bacteria BA201_27585 ENOG4105D8X mechanosensitive ion channel BA201_27590 ENOG4108ZDA Sporulation protein YyaC BA201_27595 ENOG4105FA0 parb-like partition protein BA201_27600 ENOG4107QJE Chromosome Partitioning Protein BA201_27615 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BA201_27620 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BA201_27630 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BA201_27655 ENOG4105E1K spore germination protein BA201_27660 ENOG4108B31 Spore germination protein BA201_27675 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BA201_27680 ENOG4108QY0 Membrane BA201_27695 ENOG4105CZ3 stage V sporulation protein ad BA201_27700 ENOG41090VF Stage v sporulation protein ac BA201_27715 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BA201_27730 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BA201_27780 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BA201_27800 ENOG4105W5Q DNA repair protein (RadC BA201_27980 ENOG4106A7E Transcriptional regulator BA201_27985 ENOG4108VB1 regulatoR BA201_28080 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BA201_28090 ENOG4105D9M gamma-glutamylcysteine synthetase BA201_28100 ENOG4105C4W S-formylglutathione hydrolase BA201_28110 ENOG4105KVH Transcriptional regulator