locus-tag class description CSW12_00020 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CSW12_00025 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit CSW12_00030 ENOG4105C83 adenylosuccinate lyase CSW12_00040 ENOG4105VR9 phosphoribosylformylglycinamidine synthase CSW12_00065 ENOG4108V3E phosphoribosylglycinamide formyltransferase CSW12_00075 ENOG4105C12 Phosphoribosylglycinamide synthetase CSW12_00085 ENOG4105EGI Transcriptional regulator CSW12_00110 ENOG4105C4R Atp-dependent dna helicase CSW12_00115 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) CSW12_00140 ENOG4108W2Y isochorismatase CSW12_00150 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CSW12_00155 ENOG4108UMI ABC transporter, permease CSW12_00160 ENOG4105D01 (LipO)protein CSW12_00180 ENOG4108IMY Transcriptional regulator CSW12_00210 ENOG4105F5W AtP-binding protein CSW12_00230 ENOG4105WXW Antirepressor CSW12_00370 ENOG41085W3 Transposase CSW12_00440 ENOG4105CBD Diacylglycerol kinase CSW12_00450 ENOG4108JPW Aminotransferase CSW12_00460 ENOG4105C26 Dehydrogenase CSW12_00465 ENOG4105KPY Small multidrug resistance protein CSW12_00490 ENOG4105D9N nucleoside CSW12_00495 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CSW12_00515 ENOG4108W15 Protein of unknown function (DUF1456) CSW12_00530 ENOG4105DTQ mandelate racemase muconate lactonizing CSW12_00540 ENOG4105DFD Na H antiporter CSW12_00560 ENOG4105D3R alkyl hydroperoxide reductase CSW12_00565 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) CSW12_00570 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) CSW12_00575 ENOG4107W7X Aldolase CSW12_00580 ENOG4105EHG Permease protein CSW12_00585 ENOG4105DQ5 transport system permease protein CSW12_00590 ENOG4108V5C ABC transporter CSW12_00600 ENOG4105CAY ferredoxin--nadp reductase CSW12_00620 ENOG4106UIA CSW12_00625 ENOG4106UIA CSW12_00640 ENOG4105BZU Histidine kinase CSW12_00660 ENOG410756H nucleotidyltransferase CSW12_00665 ENOG4105D2S major facilitator superfamily CSW12_00680 ENOG4105E5Q amino acid AbC transporter CSW12_00685 ENOG4105EAB amino acid AbC transporter CSW12_00695 ENOG4105C8Q Methyl-accepting chemotaxis CSW12_00710 ENOG4105DBV ornithine carbamoyltransferase CSW12_00720 ENOG4105C5B carbamate kinase CSW12_00725 ENOG4108W63 CRP FNR family transcriptional regulator CSW12_00740 ENOG4105DNP FAD linked oxidase domain protein CSW12_00750 ENOG4105CI1 PTS System CSW12_00770 ENOG4105C9U ATP-dependent DNA helicase RecQ CSW12_00785 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter CSW12_00805 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component CSW12_00810 ENOG4105D2X ABC transporter substrate-binding protein CSW12_00820 ENOG4105C5H ABC transporter CSW12_00855 ENOG41062JF Transcriptional regulator CSW12_00870 ENOG4105DEU major facilitator superfamily CSW12_00885 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) CSW12_00900 ENOG4108N0M stress protein CSW12_00905 ENOG4106FN3 tellurium resistance protein CSW12_00910 ENOG4106FN3 tellurium resistance protein CSW12_00915 ENOG4107TS3 membrane protein, TerC CSW12_00920 ENOG4108TTB tellurium resistance protein CSW12_00935 ENOG41068PA UPF0435 protein CSW12_00940 ENOG4105KJF protein tyrosine phosphatase CSW12_00950 ENOG4107U9T Pfam:Ribonuclease_BN CSW12_00960 ENOG4105C59 p-type ATPase CSW12_00965 ENOG4108IPJ Membrane CSW12_00985 ENOG4107ZTW SNARE associated Golgi CSW12_01000 ENOG410606W general stress protein CSW12_01040 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CSW12_01045 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) CSW12_01055 ENOG4108JUB Transcriptional regulator CSW12_01065 ENOG4108IQI permease CSW12_01115 ENOG4108A04 Beta-lactamase CSW12_01130 ENOG4107R51 Glycosyl transferase, family 2 CSW12_01135 ENOG4107QQG Dehydrogenase CSW12_01140 ENOG4105C3I Nad-dependent epimerase dehydratase CSW12_01145 ENOG4105CKK Glycosyl transferase, family 2 CSW12_01160 ENOG4105F1A Pyruvate formate-lyase CSW12_01180 ENOG4105CI2 imidazolone-5-propionate hydrolase CSW12_01185 ENOG4105ECP epimerase CSW12_01215 ENOG41067AE Membrane-bound metal-dependent hydrolase CSW12_01220 ENOG4105CEN a g-specific adenine glycosylase CSW12_01225 ENOG4106BXE CSW12_01245 ENOG4105BZ1 (ABC) transporter CSW12_01250 ENOG4107NBY Membrane CSW12_01255 ENOG4105CBC glutamate synthase CSW12_01265 ENOG4108IUW ABC transporter CSW12_01285 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CSW12_01290 ENOG4105G5W regulator Fur family CSW12_01415 ENOG4108JQC penicillin-binding protein 1A CSW12_01420 ENOG4108R9S DSBA oxidoreductase CSW12_01430 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) CSW12_01440 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CSW12_01455 ENOG4105CYN Serine protein kinase CSW12_01480 ENOG4105C94 Transporter CSW12_01495 ENOG4105DZ6 Band 7 protein CSW12_01505 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism CSW12_01510 ENOG4108V9W transcriptional regulatory protein CSW12_01515 ENOG4105D4T Citrate transporter CSW12_01540 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator CSW12_01545 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CSW12_01550 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component CSW12_01555 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component CSW12_01560 ENOG4105BZ7 extracellular solute-binding protein family 1 CSW12_01565 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) CSW12_01570 ENOG4108STX response regulator CSW12_01575 ENOG4105US7 Histidine kinase CSW12_01600 ENOG4108MRH transcriptional regulatory protein CSW12_01610 ENOG4105C6K Malic enzyme CSW12_01620 ENOG4108UZ3 Transporter CSW12_01625 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CSW12_01635 ENOG4105BZU Histidine kinase CSW12_01640 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CSW12_01655 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CSW12_01665 ENOG4108JB9 formate dehydrogenase CSW12_01685 ENOG4105CUB amino acid CSW12_01695 ENOG4105C59 p-type ATPase CSW12_01700 ENOG4105DAP Nicotinate phosphoribosyltransferase CSW12_01735 ENOG41073R8 VanW family CSW12_01740 ENOG4108KGH TRANSCRIPTIONal CSW12_01745 ENOG4105D9N nucleoside CSW12_01750 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase CSW12_01755 ENOG4105C37 (CBS) domain CSW12_01760 ENOG4108IJ0 Aspartate ammonia-lyase CSW12_01765 ENOG4105DAA L-lactate CSW12_01780 ENOG4105DUX Transporter CSW12_01785 ENOG4108MES Periplasmic binding protein CSW12_01790 ENOG4105DQ5 transport system permease protein CSW12_01795 ENOG4108IHU transport system permease protein CSW12_01800 ENOG4105E0A ABC, transporter CSW12_01805 ENOG4105DMQ Methyltransferase CSW12_01810 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CSW12_01815 ENOG4105EXW epimerase dehydratase CSW12_01825 ENOG4107T89 von Willebrand factor, type A CSW12_01830 ENOG4105GMT ATPase associated with various cellular activities aaa_5 CSW12_01835 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CSW12_01845 ENOG4105BZU Histidine kinase CSW12_01850 ENOG4105D5Q Arginine ornithine antiporter CSW12_01855 ENOG4107414 GntR family transcriptional regulator CSW12_01860 ENOG4105C5Y PTS System CSW12_01865 ENOG4105CG3 alpha amylase, catalytic region CSW12_01880 ENOG4105E1K spore germination protein CSW12_01885 ENOG4105CRN Aminoglycoside phosphotransferase CSW12_01890 ENOG4105BZG amino acid carrier protein CSW12_01895 ENOG4105CDA abc transporter atp-binding protein CSW12_01900 ENOG4105CT1 (ABC) transporter CSW12_01905 ENOG4105EAD ABC transporter CSW12_01910 ENOG4105DRP amino acid AbC transporter CSW12_01915 ENOG4108IQI permease CSW12_01930 ENOG4105GFR rna polymerase sigma factor CSW12_01940 ENOG4105D29 Helix-turn-helix type 11 domain protein CSW12_01945 ENOG4105NAE bifunctional deaminase-reductase domain protein CSW12_01950 ENOG4105BZU Histidine kinase CSW12_01965 ENOG4105CHH sulfate transporter CSW12_01970 ENOG41068KF Universal stress protein CSW12_01990 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CSW12_01995 ENOG4108JQ7 (ABC) transporter CSW12_02005 ENOG4105CXY transporter CSW12_02010 ENOG41067TZ transcriptional regulator, MarR family CSW12_02015 ENOG4105C0R drug resistance transporter emrb qaca subfamily CSW12_02020 ENOG4105ETE Transcriptional regulator (LacI family CSW12_02025 ENOG4108RVA ribokinase CSW12_02040 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CSW12_02245 ENOG4105XSJ toxin secretion phage lysis holin CSW12_02250 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase CSW12_02295 ENOG4105CNN ABC, transporter CSW12_02300 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CSW12_02305 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CSW12_02345 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) CSW12_02540 ENOG4105XSJ toxin secretion phage lysis holin CSW12_02610 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CSW12_02615 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer CSW12_02620 ENOG41069ER domain protein CSW12_02625 ENOG4105VZ8 Transcriptional regulator CSW12_02630 ENOG4107D63 CSW12_02645 ENOG4105DUX Transporter CSW12_02665 ENOG4105C85 amino acid CSW12_02670 ENOG4105C7N Xanthine uracil vitamin C permease CSW12_02685 ENOG4105MA6 gCN5-related N-acetyltransferase CSW12_02710 ENOG4105BZ9 Cytochrome C oxidase, subunit I CSW12_02715 ENOG4105E2S oxidase) subunit II CSW12_02735 ENOG4106CAD Protein of unknown function (DUF3311) CSW12_02740 ENOG4105E1V na solute symporter CSW12_02755 ENOG4108NHD germination protein CSW12_02765 ENOG4105CE1 Ferrous iron transport protein b CSW12_02770 ENOG4105CE1 Ferrous iron transport protein b CSW12_02775 ENOG4105CE1 Ferrous iron transport protein b CSW12_02780 ENOG4105CVA phosphate CSW12_02785 ENOG4105C8U phosphate abc transporter CSW12_02790 ENOG4105E2Z phosphate ABC transporter (Permease CSW12_02925 ENOG41080XQ Signal transduction protein with cbs domains CSW12_02950 ENOG4105ETU transcriptional activator (TenA CSW12_02960 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component CSW12_02970 ENOG4108VEU Thiamine monophosphate synthase CSW12_02975 ENOG41080HI glycine oxidase CSW12_02990 ENOG4105D06 uba thif-type nad fad binding protein CSW12_02995 ENOG4105DWF phosphomethylpyrimidine kinase CSW12_03035 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) CSW12_03050 ENOG4108INS Transcriptional regulator CSW12_03065 ENOG4105C7N Xanthine uracil vitamin C permease CSW12_03075 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein CSW12_03090 ENOG4105K63 Thioredoxin CSW12_03110 ENOG4108B31 Spore germination protein CSW12_03130 ENOG4107Y03 Nitroreductase CSW12_03135 ENOG4105ED1 spovr family CSW12_03140 ENOG410607W Transposase CSW12_03175 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 CSW12_03175 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 CSW12_03190 ENOG4105J4Q Transcriptional regulator CSW12_03210 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase CSW12_03215 ENOG4105XTG Pfam:DUF156 CSW12_03220 ENOG4105VFE sira family CSW12_03225 ENOG4107TPS domain protein CSW12_03230 ENOG4105VFE sira family CSW12_03235 ENOG41085GJ domain protein CSW12_03245 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase CSW12_03250 ENOG41087NI Sulfite exporter TauE/SafE CSW12_03260 ENOG4108KGH TRANSCRIPTIONal CSW12_03290 ENOG4105EMD TRANSCRIPTIONal CSW12_03295 ENOG4105VCP PTS System CSW12_03300 ENOG4105VZJ PTS System CSW12_03320 ENOG41069ER domain protein CSW12_03325 ENOG4107RBB ABC transporter, permease CSW12_03330 ENOG4105C19 ABC transporter CSW12_03365 ENOG4105WEF catalase CSW12_03400 ENOG4107T5V SNARE associated Golgi CSW12_03435 ENOG4105CUB amino acid CSW12_03440 ENOG4107RWR Sodium hydrogen exchanger CSW12_03450 ENOG4106KNT transcriptional regulator CSW12_03490 ENOG4108YXU transcriptional regulator AsnC family CSW12_03495 ENOG4105CH7 arginosuccinase CSW12_03500 ENOG4105UBK short-chain dehydrogenase reductase CSW12_03510 ENOG4105KPY Small multidrug resistance protein CSW12_03550 ENOG4107RKG DJ-1/PfpI family CSW12_03555 ENOG4105CH6 catalase CSW12_03565 ENOG4105D5Q Arginine ornithine antiporter CSW12_03570 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) CSW12_03580 ENOG4105C26 Dehydrogenase CSW12_03600 ENOG4105BZ1 (ABC) transporter CSW12_03605 ENOG4105BZ1 (ABC) transporter CSW12_03620 ENOG4105DRP amino acid AbC transporter CSW12_03625 ENOG4105CDA abc transporter atp-binding protein CSW12_03640 ENOG410839P CSW12_03660 ENOG4105BZU Histidine kinase CSW12_03665 ENOG4105WH1 Two component transcriptional regulator luxr family CSW12_03690 ENOG4107FQX Alpha-acetolactate decarboxylase CSW12_03715 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CSW12_03720 ENOG4105D4P Coproporphyrinogen iii oxidase CSW12_03745 ENOG4105CHH sulfate transporter CSW12_03780 ENOG4105CGU Enoyl-CoA hydratase CSW12_03825 ENOG4105CIF Ornithine Cyclodeaminase CSW12_03845 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CSW12_03850 ENOG4105C3U ABC transporter CSW12_03855 ENOG4108JQ7 (ABC) transporter CSW12_03900 ENOG4105CSH Transporter CSW12_03910 ENOG4108MRH transcriptional regulatory protein CSW12_03920 ENOG4105M6F mutator MutT protein CSW12_03925 ENOG4105C1J atp-dependent rna helicase CSW12_03935 ENOG4105CFI type iii restriction protein res subunit CSW12_03970 ENOG4105CDU Replicative dna helicase CSW12_04005 ENOG4105C0R drug resistance transporter emrb qaca subfamily CSW12_04060 ENOG4105F6J Alpha beta hydrolase fold CSW12_04110 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase CSW12_04125 ENOG4105F27 Major Facilitator CSW12_04130 ENOG4105WAB arsR family transcriptional regulator CSW12_04145 ENOG4105CMT Dihydroxyacetone kinase CSW12_04155 ENOG4105EKQ RNA-directed DNA polymerase CSW12_04175 ENOG4105CMT Dihydroxyacetone kinase CSW12_04300 ENOG4105WN5 stage II sporulation protein CSW12_04310 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CSW12_04320 ENOG4108MJI response regulator CSW12_04330 ENOG4105BZU Histidine kinase CSW12_04335 ENOG4105BZU Histidine kinase CSW12_04380 ENOG4107QHE Choloylglycine hydrolase CSW12_04400 ENOG4107VRP DNA repair exonuclease CSW12_04405 ENOG4106D4I domain protein CSW12_04420 ENOG410829K Lysine exporter protein (Lyse ygga) CSW12_04445 ENOG4108MUZ hydrolase CSW12_04465 ENOG4105F0F Oxalate decarboxylase CSW12_04470 ENOG41067QW Transcriptional regulator CSW12_04475 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator CSW12_04490 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CSW12_04500 ENOG4105EMN RNA polymerase sigma factor CSW12_04515 ENOG4105EEM helicase CSW12_04525 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CSW12_04555 ENOG4105K59 histidine triad (HIT) protein CSW12_04595 ENOG410905X membrane-flanked domain protein CSW12_04600 ENOG4105CKV Membrane CSW12_04665 ENOG410905X membrane-flanked domain protein CSW12_04670 ENOG4105CKV Membrane CSW12_04675 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation CSW12_04680 ENOG4105BZ4 penicillin-binding protein CSW12_04690 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CSW12_04695 ENOG4105C1Q protoporphyrinogen oxidase CSW12_04710 ENOG410607W Transposase CSW12_04725 ENOG4105NA0 Transcriptional regulator CSW12_04740 ENOG4105ECB domain protein CSW12_04770 ENOG4106AXD CSW12_04775 ENOG4108RQ5 Beta-lactamase domain-containing protein CSW12_04780 ENOG4105DF9 Lipoate-protein, ligase CSW12_04790 ENOG4105CEY Amp-dependent synthetase and ligase CSW12_04800 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein CSW12_04805 ENOG4108I5D sulfate abc transporter CSW12_04810 ENOG4105ECW sulfate abc transporter CSW12_04815 ENOG4108IJ6 ABC transporter CSW12_04820 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) CSW12_04830 ENOG4107RN3 metallophosphoesterase CSW12_04845 ENOG4107TVP HD domain protein CSW12_04855 ENOG4108AEY RNA polymerase sigma factor CSW12_04860 ENOG41086D8 Transcriptional regulator CSW12_04880 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CSW12_04900 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 CSW12_04905 ENOG4105C8Q Methyl-accepting chemotaxis CSW12_04915 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) CSW12_04925 ENOG4107QP3 malate synthase g CSW12_04950 ENOG4105VEQ Cold shock protein CSW12_04965 ENOG4105XVF Competence transcription factor CSW12_04990 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation CSW12_05035 ENOG4105ERH Fumarylacetoacetate hydrolase CSW12_05045 ENOG4105C8Y Acetylornithine aminotransferase CSW12_05060 ENOG4105CAQ asparagine synthetase CSW12_05075 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) CSW12_05270 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CSW12_05285 ENOG4105CAQ asparagine synthetase CSW12_05295 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CSW12_05300 ENOG4105CH6 catalase CSW12_05305 ENOG4105BZU Histidine kinase CSW12_05335 ENOG4105QNR S1 RNA binding domain protein CSW12_05360 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CSW12_05370 ENOG4107AYK membrAne CSW12_05375 ENOG41073B9 CSW12_05385 ENOG4108KP7 hydrolase CSW12_05400 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CSW12_05425 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CSW12_05430 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CSW12_05450 ENOG4105C31 Tryptophanyl-tRNA synthetase CSW12_05470 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CSW12_05475 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CSW12_05485 ENOG4108JQ7 (ABC) transporter CSW12_05490 ENOG4105UQX Mate efflux family protein CSW12_05515 ENOG4108ZCF integral membrane protein CSW12_05525 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CSW12_05535 ENOG4105DPN Oligoendopeptidase f CSW12_05550 ENOG4108Z18 K06886 hemoglobin CSW12_05555 ENOG4105MIX Adenylate cyclase CSW12_05560 ENOG4106EFP UPF0738 protein CSW12_05570 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CSW12_05575 ENOG4105EMS pseudouridine synthase CSW12_05595 ENOG4105K64 Glycosyl transferase, family 2 CSW12_05615 ENOG4107TVC Glycosyl transferase, family 2 CSW12_05635 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) CSW12_05640 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase CSW12_05650 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase CSW12_05730 ENOG4105CK7 Sodium proline symporter CSW12_05740 ENOG4105CRQ synthase (Component I) CSW12_05745 ENOG4105DDQ anthranilate synthase CSW12_05760 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase CSW12_05765 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) CSW12_05840 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CSW12_05860 ENOG4105C7S Dehydrogenase CSW12_05865 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 CSW12_05870 ENOG4105VZ8 Transcriptional regulator CSW12_05915 ENOG4108IUX (ABC) transporter CSW12_05920 ENOG4105RHA ABC transporter, permease CSW12_05950 ENOG4105DZ1 carboxypeptidase CSW12_05955 ENOG4105VFR signal peptidase CSW12_05990 ENOG4105C26 Dehydrogenase CSW12_05995 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CSW12_06000 ENOG4105F38 ABC transporter, permease CSW12_06005 ENOG4105D38 putrescine abc transporter CSW12_06010 ENOG4107RUE extracellular solute-binding protein family 1 CSW12_06020 ENOG4105EYF MMPL domain protein CSW12_06030 ENOG4108YBP pseudouridine synthase CSW12_06040 ENOG4105K4I Scp-like extracellular CSW12_06045 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CSW12_06050 ENOG4105CQB FAD linked oxidase domain protein CSW12_06065 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CSW12_06070 ENOG4105BZU Histidine kinase CSW12_06075 ENOG4105JXH GntR family transcriptional regulator CSW12_06095 ENOG4106A3R peptidase CSW12_06105 ENOG4108QTI )-transporter CSW12_06110 ENOG4107TS3 membrane protein, TerC CSW12_06115 ENOG4105CZN Potassium uptake protein CSW12_06120 ENOG410681C small acid-soluble spore protein CSW12_06125 ENOG4108Z7G MaoC domain protein dehydratase CSW12_06145 ENOG4105CHR reductase CSW12_06180 ENOG4105C4Y ABC transporter CSW12_06185 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CSW12_06190 ENOG4107RCV ABC transporter, permease CSW12_06210 ENOG4105E98 transcriptional regulator DeoR family CSW12_06225 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) CSW12_06235 ENOG4105PXI polysaccharide deacetylase CSW12_06245 ENOG4105BZU Histidine kinase CSW12_06250 ENOG41090MY MarR family Transcriptional regulator CSW12_06260 ENOG4106DF1 CSW12_06270 ENOG4105BZU Histidine kinase CSW12_06275 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) CSW12_06280 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase CSW12_06285 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) CSW12_06330 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) CSW12_06335 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CSW12_06350 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CSW12_06355 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family CSW12_06360 ENOG4105CZV ABC transporter CSW12_06370 ENOG4105CJ1 ABC, transporter CSW12_06410 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A CSW12_06415 ENOG4105EA8 2-Nitropropane dioxygenase CSW12_06420 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD CSW12_06430 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein CSW12_06455 ENOG4105NQC Flavodoxin CSW12_06515 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CSW12_06545 ENOG4105CZN Potassium uptake protein CSW12_06550 ENOG41063Y9 CSW12_06555 ENOG4105KBJ sporulation protein ytfj CSW12_06585 ENOG4105CM2 brancheD-chain amino acid aminotransferase CSW12_06590 ENOG4105C7K acetolactate synthase CSW12_06595 ENOG4108ZP8 Acetolactate synthase small subunit CSW12_06600 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CSW12_06615 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CSW12_06620 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CSW12_06630 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) CSW12_06635 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) CSW12_06640 ENOG4105ECC imidazole-glycerol-phosphate dehydratase CSW12_06645 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CSW12_06670 ENOG4107RVV histidinol phosphate phosphatase, hisj family CSW12_06685 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase CSW12_06690 ENOG4105E0M Sulfatase CSW12_06700 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CSW12_06720 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) CSW12_06725 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) CSW12_06735 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CSW12_06740 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein CSW12_06745 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein CSW12_06760 ENOG4105C8J )-transporter CSW12_06780 ENOG4105DFD Na H antiporter CSW12_06800 ENOG4105ENE Histidine kinase CSW12_06805 ENOG4105WH1 Two component transcriptional regulator luxr family CSW12_06830 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CSW12_06855 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CSW12_06880 ENOG4105CJ3 phosphate transporter CSW12_06885 ENOG4107GRR phosphate transport regulator CSW12_06890 ENOG4105BZ4 penicillin-binding protein CSW12_06905 ENOG4105BZU Histidine kinase CSW12_06910 ENOG4105I3N Conserved Protein CSW12_06925 ENOG4105BZU Histidine kinase CSW12_06955 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CSW12_06960 ENOG4105DZ1 carboxypeptidase CSW12_06965 ENOG4108JIC nucleoside recognition domain protein CSW12_06975 ENOG4105FE9 pseudouridine synthase CSW12_06980 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CSW12_06985 ENOG4107TWT Cytochrome c biogenesis protein CSW12_06990 ENOG4105CRE cytochrome C CSW12_06995 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CSW12_07000 ENOG4105BZU Histidine kinase CSW12_07005 ENOG4108WBT adenosyltransferase CSW12_07020 ENOG4108SAX Membrane CSW12_07025 ENOG410607W Transposase CSW12_07040 ENOG4105C9U ATP-dependent DNA helicase RecQ CSW12_07045 ENOG4105I7S Abortive infection protein CSW12_07055 ENOG4107RGJ metallophosphoesterase CSW12_07060 ENOG4108XDN Transcriptional regulator CSW12_07065 ENOG4108S6Z Negative regulator of genetic competence CSW12_07090 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase CSW12_07095 ENOG4107RB3 L-asparaginase CSW12_07140 ENOG4105S2F CSW12_07145 ENOG41065D1 CSW12_07170 ENOG4105ETE Transcriptional regulator (LacI family CSW12_07180 ENOG4107SKW Inherit from COG: Alpha beta hydrolase CSW12_07205 ENOG4105RHY Pfam:UPF0157 CSW12_07215 ENOG4105CPC Aldo Keto reductase CSW12_07235 ENOG4105MZ9 stage II sporulation protein m CSW12_07240 ENOG4105I3K Ferric uptake regulator, Fur family CSW12_07250 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CSW12_07275 ENOG4105D7N magnesium and cobalt transport protein CorA CSW12_07305 ENOG4105DVE abc transporter atp-binding protein CSW12_07310 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family CSW12_07320 ENOG4105DZ1 carboxypeptidase CSW12_07325 ENOG41082AN stage II sporulation protein CSW12_07335 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CSW12_07340 ENOG4105C8J )-transporter CSW12_07360 ENOG41090VF Stage v sporulation protein ac CSW12_07365 ENOG4105CZ3 stage V sporulation protein ad CSW12_07375 ENOG4105G6R Stage v sporulation protein ae CSW12_07385 ENOG4105DQF Hydrolase CSW12_07390 ENOG4105PTM secreted protein CSW12_07395 ENOG4107ZE5 PPIases accelerate the folding of proteins CSW12_07435 ENOG4105CE4 GlcNAc 6-P deacetylase CSW12_07445 ENOG4105FDP GntR family transcriptional regulator CSW12_07455 ENOG4105CID antiterminator CSW12_07470 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) CSW12_07490 ENOG4105BZU Histidine kinase CSW12_07500 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CSW12_07515 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) CSW12_07540 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase CSW12_07560 ENOG4105DTD Dehydrogenase CSW12_07565 ENOG4105K7K Transcriptional regulator CSW12_07600 ENOG4105CHU acetyl-coa acetyltransferase CSW12_07615 ENOG4105C5I Dehydrogenase CSW12_07630 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain CSW12_07680 ENOG4105CG3 alpha amylase, catalytic region CSW12_07690 ENOG4107FKK extracellular solute-binding protein family 1 CSW12_07700 ENOG4105EG2 ABC transporter, permease CSW12_07705 ENOG4105FKQ transcriptional regulator CSW12_07710 ENOG4105CHM Aminotransferase CSW12_07720 ENOG4108HGU Histidine kinase CSW12_07745 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) CSW12_07780 ENOG4105UIN CSW12_07790 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) CSW12_07805 ENOG4105K6S Short-chain dehydrogenase reductase Sdr CSW12_07810 ENOG4105EPM Diguanylate phosphodiesterase CSW12_07825 ENOG4107IN1 Protein of unknown function (DUF1797) CSW12_07835 ENOG4108XRC Protein of unknown function (DUF458) CSW12_07870 ENOG4107ZYR domain protein CSW12_07875 ENOG4105CN5 Metallo-Beta-Lactamase CSW12_07890 ENOG4108X4Q Hydrolase CSW12_07895 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CSW12_07910 ENOG4105CPP Dehydrogenase, E1 component CSW12_07960 ENOG4105CXN decarboxylase CSW12_07980 ENOG4105ECY inositol monophosphatase CSW12_07990 ENOG4105CI3 gtp-binding protein typa CSW12_07995 ENOG4105QA2 CSW12_08015 ENOG4108IAB Phoh family CSW12_08030 ENOG4105CNI cell division protein FtsW CSW12_08040 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) CSW12_08090 ENOG4106UY4 Inherit from COG: Scp-like extracellular CSW12_08105 ENOG4107TB6 phosphoglycerate mutase CSW12_08125 ENOG4106H78 methyltransferase CSW12_08135 ENOG4105H20 Sporulation integral membrane protein YlbJ CSW12_08140 ENOG4105D78 K07001 NTE family protein CSW12_08145 ENOG41063PX domain protein CSW12_08155 ENOG4105KNH Nucleic acid-binding protein CSW12_08185 ENOG41074B2 UPF0747 protein CSW12_08200 ENOG4105CJN penicillin-binding protein CSW12_08205 ENOG4105CJN penicillin-binding protein CSW12_08210 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CSW12_08225 ENOG4105CNI cell division protein FtsW CSW12_08230 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CSW12_08235 ENOG4105D4A Cell wall formation (By similarity) CSW12_08245 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CSW12_08250 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CSW12_08260 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CSW12_08270 ENOG4105WR5 sporulation protein, YlmC YmxH family CSW12_08275 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CSW12_08280 ENOG4105DFA alanine racemase domain protein CSW12_08290 ENOG41067XK integral membrane protein CSW12_08295 ENOG4105DBK s4 domain protein CSW12_08305 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CSW12_08320 ENOG4105C34 Pseudouridine synthase CSW12_08355 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) CSW12_08400 ENOG4105DC7 peptidase M24 CSW12_08420 ENOG4105F23 Fibronectin-binding protein CSW12_08430 ENOG4105DSJ YicC domain protein CSW12_08450 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase CSW12_08455 ENOG4105C25 Primosomal protein n' CSW12_08470 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CSW12_08480 ENOG4108ZF3 Phosphatase CSW12_08485 ENOG4105D9P serine threonine protein kinase CSW12_08490 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CSW12_08495 ENOG4105DJV ribulose-phosphate 3-epimerase CSW12_08500 ENOG4105FJ0 thiamine CSW12_08515 ENOG4108ZAA Alkaline-shock protein CSW12_08520 ENOG4105DP4 dak2 domain fusion protein ylov CSW12_08525 ENOG4105CB5 ATP-dependent DNA helicase recG CSW12_08540 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CSW12_08545 ENOG4105CHR reductase CSW12_08560 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) CSW12_08565 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CSW12_08585 ENOG4105VB6 UPF0109 protein CSW12_08610 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) CSW12_08625 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha CSW12_08630 ENOG4105C79 DNA protecting protein DprA CSW12_08635 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CSW12_08645 ENOG4108HE4 integrase family CSW12_08675 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) CSW12_08685 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CSW12_08690 ENOG4105KNE Phosphatidate cytidylyltransferase CSW12_08695 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) CSW12_08700 ENOG4105DZP Membrane-associated zinc metalloprotease CSW12_08710 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CSW12_08720 ENOG4105CHV Transcription elongation factor NusA CSW12_08725 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination CSW12_08730 ENOG4105VHM ribosomal protein CSW12_08740 ENOG4105W7A Protein of unknown function (DUF503) CSW12_08755 ENOG4105DTN riboflavin biosynthesis protein ribF CSW12_08775 ENOG4105C1V Peptidase, M16 CSW12_08785 ENOG4105E35 Dipicolinate synthase subunit A CSW12_08790 ENOG4108S0H Dipicolinic acid synthetase, b subunit CSW12_08795 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CSW12_08805 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CSW12_08815 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit CSW12_08825 ENOG4105CNU cell division protein FtsK CSW12_08835 ENOG4105FDP GntR family transcriptional regulator CSW12_08840 ENOG4105DIH basic membrane CSW12_08845 ENOG4108JQ9 ABC transporter CSW12_08850 ENOG4105UIB (ABC) transporter CSW12_08870 ENOG4108RKS Short-chain dehydrogenase reductase Sdr CSW12_08875 ENOG4105XZV Protein of unknown function (DUF3243) CSW12_08890 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CSW12_08915 ENOG4105D48 metallophosphoesterase CSW12_08920 ENOG4105MCT stage V sporulation protein S CSW12_08925 ENOG4108IGT Dipeptidase CSW12_08930 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein CSW12_08935 ENOG4105DQU oxidoreductase, subunit beta CSW12_08970 ENOG410890F Dynamin family CSW12_08975 ENOG4105E0M Sulfatase CSW12_08990 ENOG4105F0V Cell wall hydrolase CSW12_09005 ENOG4105CS2 ec 3.2.1.21 CSW12_09010 ENOG4108S3Y transcriptional regulator CSW12_09030 ENOG41067MG lrgb family CSW12_09070 ENOG4105BZU Histidine kinase CSW12_09100 ENOG4105D03 DNA-3-methyladenine glycosylase II CSW12_09105 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CSW12_09115 ENOG4105CGK Exodeoxyribonuclease III CSW12_09135 ENOG4105E0A ABC, transporter CSW12_09140 ENOG4105NIV Esterase CSW12_09150 ENOG4105VPX protein, conserved in bacteria CSW12_09155 ENOG410681U heavy metal transport detoxification protein CSW12_09160 ENOG4105C59 p-type ATPase CSW12_09170 ENOG4105K70 DNA-binding protein CSW12_09175 ENOG4105TMB Formate nitrite transporter CSW12_09200 ENOG4105C85 amino acid CSW12_09215 ENOG4108SJC Membrane CSW12_09220 ENOG4107QW4 alcohol dehydrogenase CSW12_09225 ENOG4105E98 transcriptional regulator DeoR family CSW12_09230 ENOG4105DE4 1-phosphofructokinase CSW12_09235 ENOG4105DM4 PTS System CSW12_09245 ENOG41069ER domain protein CSW12_09275 ENOG4106F1P AAA ATPase, central domain protein CSW12_09280 ENOG4105EN6 Membrane CSW12_09285 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CSW12_09290 ENOG4105CXI aluminum resistance protein CSW12_09295 ENOG4105KV4 Transcriptional regulator CSW12_09300 ENOG4105C5F glutamine synthetase CSW12_09305 ENOG4105K7K Transcriptional regulator CSW12_09325 ENOG4108SVB resolvase CSW12_09335 ENOG4105CGH 5'-nucleotidase CSW12_09340 ENOG4108HW3 (ABC) transporter CSW12_09375 ENOG4105BZ1 (ABC) transporter CSW12_09380 ENOG4105BZ1 (ABC) transporter CSW12_09420 ENOG41067MG lrgb family CSW12_09425 ENOG4105VAW lrga family CSW12_09430 ENOG4107RSM transcriptional regulator CSW12_09445 ENOG4105CJ1 ABC, transporter CSW12_09455 ENOG4105CH2 amidohydrolase CSW12_09470 ENOG4107QIV Cytochrome c biogenesis protein CSW12_09505 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) CSW12_09530 ENOG4108903 Formimidoylglutamase CSW12_09535 ENOG4108VJ1 Transcriptional regulator (CarD family CSW12_09540 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CSW12_09545 ENOG4105CBC glutamate synthase CSW12_09555 ENOG4105CK7 Sodium proline symporter CSW12_09560 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase CSW12_09565 ENOG4105FBA Phospholipase Carboxylesterase CSW12_09570 ENOG4105BZU Histidine kinase CSW12_09585 ENOG4107AYK membrAne CSW12_09630 ENOG4108IMY Transcriptional regulator CSW12_09635 ENOG4105CEY Amp-dependent synthetase and ligase CSW12_09640 ENOG4107ZYJ bioY protein CSW12_09645 ENOG4107F3J Amp-dependent synthetase and ligase CSW12_09665 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CSW12_09675 ENOG4105E5W Transporter CSW12_09705 ENOG4108I0Z Aconitate hydratase CSW12_09710 ENOG4108JJA ABC, transporter CSW12_09720 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CSW12_09725 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CSW12_09750 ENOG4105W8X HesB YadR YfhF-family protein CSW12_09755 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CSW12_09760 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase CSW12_09770 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CSW12_09775 ENOG4105C0H protease CSW12_09780 ENOG4105K4P CoA-binding domain protein CSW12_09790 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CSW12_09800 ENOG4105D9R oxidoreductase CSW12_09820 ENOG4105CIG ABC transporter CSW12_09830 ENOG4105EMN RNA polymerase sigma factor CSW12_09840 ENOG4108KGH TRANSCRIPTIONal CSW12_09895 ENOG4105CUB amino acid CSW12_09910 ENOG4105E1K spore germination protein CSW12_09920 ENOG4108JB9 formate dehydrogenase CSW12_09930 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) CSW12_09935 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CSW12_09950 ENOG4105TMB Formate nitrite transporter CSW12_09955 ENOG4105D06 uba thif-type nad fad binding protein CSW12_09960 ENOG4105CVM Molybdenum cofactor synthesis domain protein CSW12_09965 ENOG4108ZAF Molybdopterin CSW12_09975 ENOG4105D1F ATP-binding protein CSW12_09990 ENOG410696E Membrane CSW12_09995 ENOG4105FR1 rard protein CSW12_10005 ENOG4105EWU Squalene--hopene cyclase CSW12_10015 ENOG4105CHR reductase CSW12_10020 ENOG4105C26 Dehydrogenase CSW12_10030 ENOG4108IA2 Sodium pantothenate symporter CSW12_10045 ENOG4106IQC argininosuccinate lyase CSW12_10055 ENOG410904N short-chain dehydrogenase reductase CSW12_10095 ENOG4105VEQ Cold shock protein CSW12_10110 ENOG4108R1P CSW12_10120 ENOG41073R8 VanW family CSW12_10125 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase CSW12_10140 ENOG4105KT7 mgtC SapB transporter CSW12_10150 ENOG4105BZU Histidine kinase CSW12_10170 ENOG4105EKQ RNA-directed DNA polymerase CSW12_10185 ENOG4107DUR UPF0457 protein CSW12_10190 ENOG4108VXD carboxy-peptidase CSW12_10200 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity CSW12_10205 ENOG41067SE Tetr family transcriptional regulator CSW12_10215 ENOG4105BZU Histidine kinase CSW12_10285 ENOG4105FAW cDP-glucose 4,6-dehydratase CSW12_10290 ENOG4108IAJ Nad-dependent epimerase dehydratase CSW12_10300 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase CSW12_10320 ENOG4105E1K spore germination protein CSW12_10340 ENOG4108M1A Chitin-binding protein CSW12_10345 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C CSW12_10365 ENOG4107TPS domain protein CSW12_10380 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase CSW12_10405 ENOG4105CQB FAD linked oxidase domain protein CSW12_10410 ENOG4105C09 Bile acid CSW12_10430 ENOG4105CNG UPF0061 protein CSW12_10435 ENOG4105CB2 alcohol dehydrogenase CSW12_10440 ENOG41082BM Transcriptional regulator, arsr family CSW12_10450 ENOG4107VXM glycerophosphoryl diester phosphodiesterase CSW12_10475 ENOG4108A04 Beta-lactamase CSW12_10510 ENOG4105DPN Oligoendopeptidase f CSW12_10515 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase CSW12_10520 ENOG4105E5K Alpha-amylase CSW12_10530 ENOG4105C98 muts2 protein CSW12_10550 ENOG4107V2S Transcriptional regulator CSW12_10560 ENOG4107CUJ Protein of unknown function (DUF2690) CSW12_10565 ENOG4105D9U N-acetyltransferase CSW12_10590 ENOG4105NX3 Membrane CSW12_10595 ENOG4105DQ5 transport system permease protein CSW12_10600 ENOG4105EHG Permease protein CSW12_10605 ENOG4108MES Periplasmic binding protein CSW12_10620 ENOG4107R3E Citrate transporter CSW12_10630 ENOG4108TN2 lmbE family CSW12_10675 ENOG4105CIS alcohol dehydrogenase CSW12_10710 ENOG4105H3G oxidoreductase CSW12_10755 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) CSW12_10830 ENOG4108ZJ4 polysaccharide deacetylase CSW12_10840 ENOG4105KVH Transcriptional regulator CSW12_10845 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein CSW12_10865 ENOG4105CAQ asparagine synthetase CSW12_10945 ENOG4105D9R oxidoreductase CSW12_10950 ENOG4108TZY GntR Family Transcriptional Regulator CSW12_10985 ENOG4105C44 Serine transporter CSW12_11000 ENOG4105CHH sulfate transporter CSW12_11005 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA CSW12_11045 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CSW12_11050 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CSW12_11055 ENOG4105CV1 Transketolase (EC 2.2.1.1) CSW12_11070 ENOG4105C6Z Gluconate CSW12_11090 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) CSW12_11095 ENOG4105XDF Protein of unknown function (DUF1272) CSW12_11100 ENOG4105DDN Pentapeptide repeat-containing protein CSW12_11130 ENOG4105FAW cDP-glucose 4,6-dehydratase CSW12_11135 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase CSW12_11150 ENOG4105C37 (CBS) domain CSW12_11180 ENOG4105EV4 Multidrug resistance protein mdtH CSW12_11190 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) CSW12_11225 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) CSW12_11230 ENOG4105C31 Tryptophanyl-tRNA synthetase CSW12_11235 ENOG4108UW5 maltose o-acetyltransferase CSW12_11240 ENOG4106UW1 Major Facilitator superfamily CSW12_11245 ENOG4105DKQ ROK family CSW12_11250 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase CSW12_11320 ENOG4108PSK reductase CSW12_11355 ENOG4108RCM Nitroreductase CSW12_11360 ENOG4105KVH Transcriptional regulator CSW12_11380 ENOG4108Z66 YbaK ebsC protein CSW12_11390 ENOG41067QW Transcriptional regulator CSW12_11400 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) CSW12_11415 ENOG4108K8S endonuclease I CSW12_11475 ENOG4105DYS nad(p)h dehydrogenase (quinone) CSW12_11485 ENOG4105CRW Short chain fatty acid transporter CSW12_11495 ENOG41069JR CSW12_11500 ENOG4105DA5 (ABC) transporter CSW12_11515 ENOG4105CZM Major Facilitator CSW12_11520 ENOG4107MII Sugar-specific transcriptional regulator TrmB CSW12_11535 ENOG4108ISG Major Facilitator CSW12_11545 ENOG4105PNM synthesis protein CSW12_11550 ENOG4108VXD carboxy-peptidase CSW12_11570 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CSW12_11600 ENOG410874W AraC family transcriptional regulator CSW12_11610 ENOG41082W1 Cupin 2, conserved barrel domain protein CSW12_11625 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) CSW12_11630 ENOG4108JQ1 Dehydrogenase CSW12_11650 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A CSW12_11660 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) CSW12_11670 ENOG4105BZU Histidine kinase CSW12_11690 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) CSW12_11710 ENOG4105JQZ Methyltransferase CSW12_11720 ENOG4105E0Y RtcB Protein CSW12_11730 ENOG4105K6H D-cysteine desulfhydrase CSW12_11755 ENOG4105C0R drug resistance transporter emrb qaca subfamily CSW12_11760 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CSW12_11820 ENOG4107RF6 penicillin-binding protein CSW12_11840 ENOG4108J5H Homocysteine s-methyltransferase CSW12_11845 ENOG4108IQI permease CSW12_11860 ENOG4105BZ4 penicillin-binding protein CSW12_11910 ENOG41062D9 Histidine kinase CSW12_11915 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CSW12_11945 ENOG4105N0V mono-oxygenase ydhR CSW12_11985 ENOG4108YXU transcriptional regulator AsnC family CSW12_11990 ENOG4105CHR reductase CSW12_11995 ENOG4108IG5 Transcriptional regulator CSW12_12000 ENOG4107P5I polyketide synthase CSW12_12005 ENOG41085FC arsR family transcriptional regulator CSW12_12010 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase CSW12_12015 ENOG4105D6J arsenicaL-resistance protein CSW12_12025 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CSW12_12030 ENOG4105KY5 gCN5-related N-acetyltransferase CSW12_12035 ENOG4107VMI polysaccharide deacetylase CSW12_12055 ENOG4105C0R drug resistance transporter emrb qaca subfamily CSW12_12060 ENOG4105GPN Uncharacterized conserved protein (DUF2294) CSW12_12065 ENOG4108TWJ NADH dehydrogenase subunit 5 CSW12_12080 ENOG4105F2M alpha beta hydrolase fold-3 domain protein CSW12_12100 ENOG4105CVP deoxyribo-dipyrimidine photolyase CSW12_12105 ENOG4108606 TspO/MBR family CSW12_12120 ENOG4105F6J Alpha beta hydrolase fold CSW12_12145 ENOG41090MY MarR family Transcriptional regulator CSW12_12180 ENOG4105CHJ isochorismatase hydrolase CSW12_12195 ENOG4105CGH 5'-nucleotidase CSW12_12210 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CSW12_12220 ENOG4105E2A Dehydrogenase CSW12_12245 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) CSW12_12285 ENOG4105DWD nucleoside recognition domain protein CSW12_12300 ENOG4105FDT acyl-CoA dehydrogenase CSW12_12310 ENOG4108ZHR arsR family transcriptional regulator CSW12_12315 ENOG4106N3A copper homeostasis protein cutc CSW12_12325 ENOG4107258 Transcriptional regulator CSW12_12330 ENOG4105P4J Allophanate hydrolase, subunit 1 CSW12_12340 ENOG4105E7W lamb ycsf family protein CSW12_12360 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CSW12_12365 ENOG4107RF6 penicillin-binding protein CSW12_12405 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CSW12_12415 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CSW12_12430 ENOG4105F1N DNA alkylation repair CSW12_12440 ENOG4108IQI permease CSW12_12455 ENOG410635A Membrane CSW12_12475 ENOG4105RHY Pfam:UPF0157 CSW12_12500 ENOG4108PCN EamA-like transporter family CSW12_12515 ENOG4108XET gCN5-related N-acetyltransferase CSW12_12520 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF CSW12_12540 ENOG4105CMR udp-glucose 4-epimerase CSW12_12545 ENOG4105WEC Molybdate metabolism regulator CSW12_12550 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) CSW12_12570 ENOG4105FS7 Transcriptional regulator CSW12_12575 ENOG4108TVJ Nitroreductase CSW12_12585 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CSW12_12650 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CSW12_12680 ENOG41068WN CSW12_12705 ENOG4105VMP Transcriptional regulator CSW12_12715 ENOG4105G6Z alkaline phosphatase CSW12_12720 ENOG4107RBI VanW family CSW12_12730 ENOG4105ECK Fatty Acid Desaturase CSW12_12755 ENOG4107258 Transcriptional regulator CSW12_12765 ENOG4105II7 pyrroline-5-carboxylate reductase CSW12_12800 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) CSW12_12815 ENOG41061GT Aldolase CSW12_12825 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) CSW12_12830 ENOG4105DKT Transcriptional regulator CSW12_12840 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane CSW12_12845 ENOG4105F5R ABC transporter CSW12_12850 ENOG4105D4B ABC, transporter CSW12_12875 ENOG4105DNP FAD linked oxidase domain protein CSW12_12890 ENOG41069ER domain protein CSW12_12915 ENOG410607W Transposase CSW12_12930 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase CSW12_12940 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CSW12_12965 ENOG41082JN Transcriptional regulator CSW12_12970 ENOG4105EYF MMPL domain protein CSW12_12975 ENOG4105C5H ABC transporter CSW12_12980 ENOG4105E0M Sulfatase CSW12_12985 ENOG4108ZCF integral membrane protein CSW12_12995 ENOG4107VMI polysaccharide deacetylase CSW12_13010 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase CSW12_13015 ENOG4105C6T cysteine synthase CSW12_13020 ENOG4107VC0 DNA alkylation repair enzyme CSW12_13065 ENOG4108AQF aminoglycoside N(3)-acetyltransferase CSW12_13090 ENOG4105D7T ABC transporter CSW12_13095 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein CSW12_13100 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CSW12_13105 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) CSW12_13120 ENOG4105C02 permease CSW12_13180 ENOG4105DVE abc transporter atp-binding protein CSW12_13195 ENOG4108ZMI UPF0477 protein CSW12_13210 ENOG4105CHM Aminotransferase CSW12_13250 ENOG41089UC methyltransferase, type 11 CSW12_13265 ENOG4107BMA Transglycosylase associated protein CSW12_13290 ENOG4106K7D Major facilitator family transporter CSW12_13295 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) CSW12_13350 ENOG4105EPR degv family CSW12_13355 ENOG4105DPN Oligoendopeptidase f CSW12_13375 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 CSW12_13390 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CSW12_13395 ENOG4105BZU Histidine kinase CSW12_13400 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CSW12_13410 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) CSW12_13440 ENOG4107SET aldo keto reductase CSW12_13455 ENOG4105DTQ mandelate racemase muconate lactonizing CSW12_13470 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD CSW12_13480 ENOG4107T5V SNARE associated Golgi CSW12_13515 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein CSW12_13525 ENOG41080HI glycine oxidase CSW12_13530 ENOG4105CTU Proline racemase CSW12_13535 ENOG4105CTU Proline racemase CSW12_13540 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CSW12_13545 ENOG4105C26 Dehydrogenase CSW12_13550 ENOG4105BZG amino acid carrier protein CSW12_13570 ENOG4108M1A Chitin-binding protein CSW12_13630 ENOG4105C9U ATP-dependent DNA helicase RecQ CSW12_13635 ENOG41066HZ AIG2-like family CSW12_13645 ENOG4105EEM helicase CSW12_13670 ENOG4108Z7F N-acetyltransferase CSW12_13690 ENOG4105MSB protein, conserved in bacteria CSW12_13720 ENOG4108M1A Chitin-binding protein CSW12_13725 ENOG41082BV acetyltransferase CSW12_13730 ENOG4105E66 phosphoriboisomerase A CSW12_13755 ENOG4108IJ7 Glycine betaine CSW12_13760 ENOG4107SQ8 Glycine betaine CSW12_13805 ENOG4105E1F short-chain dehydrogenase reductase CSW12_13815 ENOG4107RUY (E1 component), alpha subunit CSW12_13825 ENOG4107QKR Dehydrogenase CSW12_13845 ENOG41062ES Transcriptional regulator CSW12_13860 ENOG4105E98 transcriptional regulator DeoR family CSW12_13880 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family CSW12_13925 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) CSW12_13930 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) CSW12_13970 ENOG4105MSI germination protein ypeb CSW12_14015 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) CSW12_14020 ENOG4105CIS alcohol dehydrogenase CSW12_14030 ENOG4105FDR Membrane CSW12_14035 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CSW12_14050 ENOG4105CGH 5'-nucleotidase CSW12_14060 ENOG4108IUM Glycogen debranching enzyme CSW12_14075 ENOG4105DY8 decarboxylase CSW12_14090 ENOG4107WD8 ABC transporter, permease CSW12_14110 ENOG4105BZU Histidine kinase CSW12_14115 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CSW12_14120 ENOG4105U0R haloacid dehalogenase-like hydrolase CSW12_14150 ENOG4107VFR oxidoreductase CSW12_14195 ENOG4105PKS Excinuclease abc c subunit domain protein CSW12_14220 ENOG4108YYS metal-dependent hydrolase (By similarity) CSW12_14230 ENOG4105KWG Pfam:DUF1696 CSW12_14235 ENOG4108NRW Phospholipase, patatin family CSW12_14260 ENOG4108XI2 Domain of unknown function (DUF1963) CSW12_14285 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CSW12_14290 ENOG4105E09 nadh pyrophosphatase CSW12_14300 ENOG4105FCD Major Facilitator CSW12_14325 ENOG4105EGD dinuclear metal center protein, YbgI family CSW12_14345 ENOG4107Y9U Membrane CSW12_14370 ENOG4107VXM glycerophosphoryl diester phosphodiesterase CSW12_14395 ENOG4108Z5V transcriptional regulator, merr family CSW12_14400 ENOG4107Y80 Major Facilitator superfamily CSW12_14450 ENOG4105CJN penicillin-binding protein CSW12_14455 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase CSW12_14460 ENOG4105CB2 alcohol dehydrogenase CSW12_14535 ENOG4105VTR Integrase CSW12_14540 ENOG4108HGU Histidine kinase CSW12_14555 ENOG4108JJB ABC transporter CSW12_14575 ENOG410607W Transposase CSW12_14585 ENOG4107RF6 penicillin-binding protein CSW12_14590 ENOG4105BZU Histidine kinase CSW12_14595 ENOG410667J hydrolase CSW12_14700 ENOG4105ETU transcriptional activator (TenA CSW12_14705 ENOG4105CPF Cell wall formation (By similarity) CSW12_14715 ENOG4105D6E homoserine dehydrogenase CSW12_14790 ENOG4105DK7 lysyl-tRNA synthetase CSW12_14800 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein CSW12_14810 ENOG4108V4B ThiJ pfpI CSW12_14815 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) CSW12_14820 ENOG410900G Protein of unknown function (DUF421) CSW12_14830 ENOG4105CPQ Dehydrogenase CSW12_14845 ENOG4105EFA 4-hydroxyphenylacetate CSW12_14890 ENOG41089UC methyltransferase, type 11 CSW12_14895 ENOG4105KVH Transcriptional regulator CSW12_14900 ENOG41061TZ Short-chain dehydrogenase reductase Sdr CSW12_14940 ENOG41075H3 AraC family transcriptional regulator CSW12_14960 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) CSW12_14985 ENOG4105DZ1 carboxypeptidase CSW12_15010 ENOG4105DBI uridine monophosphokinase CSW12_15030 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CSW12_15035 ENOG4107QX3 carboxylase CSW12_15040 ENOG4105E39 Enoyl-CoA hydratase CSW12_15045 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase CSW12_15050 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit CSW12_15055 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CSW12_15060 ENOG4105C1G acyl-Coa dehydrogenase CSW12_15075 ENOG4107Z3H Transcriptional regulator, TetR family CSW12_15085 ENOG4105CJ1 ABC, transporter CSW12_15095 ENOG4105DIN metallophosphoesterase CSW12_15115 ENOG4107RF6 penicillin-binding protein CSW12_15120 ENOG4107RF6 penicillin-binding protein CSW12_15135 ENOG4107RVG penicillin-binding protein CSW12_15145 ENOG4105CJW magnesium transporter CSW12_15155 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) CSW12_15170 ENOG4105F6S Spore photoproduct lyase CSW12_15190 ENOG4105C44 Serine transporter CSW12_15195 ENOG4105EJQ L-serine dehydratase CSW12_15275 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin CSW12_15285 ENOG4108XG2 Histidine kinase CSW12_15310 ENOG41082BM Transcriptional regulator, arsr family CSW12_15325 ENOG41067TZ transcriptional regulator, MarR family CSW12_15335 ENOG410607W Transposase CSW12_15345 ENOG4108RZE Tetr family transcriptional regulator CSW12_15350 ENOG4107VMI polysaccharide deacetylase CSW12_15370 ENOG4108IMY Transcriptional regulator CSW12_15415 ENOG4108B31 Spore germination protein CSW12_15425 ENOG4105BZU Histidine kinase CSW12_15450 ENOG41075H3 AraC family transcriptional regulator CSW12_15470 ENOG4105YWU small acid-soluble spore protein CSW12_15475 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CSW12_15480 ENOG4105CUB amino acid CSW12_15485 ENOG4105II7 pyrroline-5-carboxylate reductase CSW12_15495 ENOG4108Q8B Spore germination protein CSW12_15585 ENOG4105EQK -acetyltransferase CSW12_15590 ENOG4105EJ9 Membrane CSW12_15600 ENOG4105KRN Transcriptional regulator, abrb family CSW12_15630 ENOG4105CIN aminoacyl-histidine dipeptidase CSW12_15685 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CSW12_15690 ENOG4105K56 Transcriptional regulator CSW12_15695 ENOG4107RA9 decarboxylase CSW12_15700 ENOG4108I0C methyltransferase CSW12_15710 ENOG41088CC tellurite resistance protein tehB CSW12_15715 ENOG4105C1J atp-dependent rna helicase CSW12_15725 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CSW12_15740 ENOG4108INS Transcriptional regulator CSW12_15745 ENOG4105C7B Threonine dehydratase CSW12_15755 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CSW12_15760 ENOG4105RD7 BadF BadG BcrA BcrD CSW12_15785 ENOG4105F32 YngK protein CSW12_15815 ENOG4108KPJ rna polymerase sigma factor CSW12_15820 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) CSW12_15855 ENOG4108JCI Transcriptional regulator CSW12_15895 ENOG4105BZ1 (ABC) transporter CSW12_15900 ENOG4105BZ1 (ABC) transporter CSW12_15915 ENOG4108RPX mosc domain containing protein CSW12_15920 ENOG4105DND Transcriptional regulator CSW12_15940 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CSW12_15945 ENOG4107V2S Transcriptional regulator CSW12_15975 ENOG41068WN CSW12_15985 ENOG4105C1Q protoporphyrinogen oxidase CSW12_16010 ENOG4105WCN acetyltransferase CSW12_16035 ENOG4105EYF MMPL domain protein CSW12_16045 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CSW12_16070 ENOG41081I9 integral membrane protein CSW12_16085 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) CSW12_16125 ENOG4105C19 ABC transporter CSW12_16130 ENOG4105C22 threonyL-tRNA synthetase CSW12_16135 ENOG4105FE9 pseudouridine synthase CSW12_16155 ENOG4105BZG amino acid carrier protein CSW12_16175 ENOG4105K70 DNA-binding protein CSW12_16190 ENOG4105C0R drug resistance transporter emrb qaca subfamily CSW12_16195 ENOG4105WQT MbtH domain protein CSW12_16200 ENOG4105CEY Amp-dependent synthetase and ligase CSW12_16205 ENOG4105WQI isochorismatase CSW12_16210 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase CSW12_16215 ENOG4105E4F Isochorismate synthase CSW12_16220 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase CSW12_16230 ENOG4105FCD Major Facilitator CSW12_16265 ENOG4105EYH Exonuclease CSW12_16270 ENOG4107RFY SbcCD D subunit CSW12_16285 ENOG4105E39 Enoyl-CoA hydratase CSW12_16290 ENOG4105N14 lysine exporter protein LysE YggA CSW12_16300 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CSW12_16305 ENOG4105C1G acyl-Coa dehydrogenase CSW12_16310 ENOG4105CR4 methylisocitrate lyase CSW12_16315 ENOG4105DXD 2-methylcitrate dehydratase CSW12_16325 ENOG4105W8X HesB YadR YfhF-family protein CSW12_16330 ENOG4105CZM Major Facilitator CSW12_16340 ENOG4105BZ4 penicillin-binding protein CSW12_16395 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CSW12_16445 ENOG4105KNA -acetyltransferase CSW12_16450 ENOG4105SZ6 Thioredoxin CSW12_16460 ENOG410841Q phosphoesterase PA-phosphatase related protein CSW12_16505 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein CSW12_16515 ENOG4108JUB Transcriptional regulator CSW12_16520 ENOG4108TSC N-acetyltransferase CSW12_16525 ENOG4107S4Y M20 DapE family protein YgeY CSW12_16540 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CSW12_16565 ENOG4105C37 (CBS) domain CSW12_16600 ENOG4105E90 ABC transporter CSW12_16605 ENOG4108IJ8 ABC transporter CSW12_16635 ENOG4108YV3 Protein of unknown function (DUF2711) CSW12_16645 ENOG4105C6Z Gluconate CSW12_16650 ENOG4105CMG Carbohydrate kinase CSW12_16670 ENOG4107ZY0 Phenazine biosynthesis-like protein CSW12_16675 ENOG4106KNT transcriptional regulator CSW12_16680 ENOG4105WH1 Two component transcriptional regulator luxr family CSW12_16685 ENOG4105BZU Histidine kinase CSW12_16690 ENOG4105D8X mechanosensitive ion channel CSW12_16795 ENOG4105F0I Aminotransferase CSW12_16800 ENOG4108MES Periplasmic binding protein CSW12_16805 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CSW12_16820 ENOG4105CAQ asparagine synthetase CSW12_16825 ENOG4107Y70 Heat shock protein CSW12_16830 ENOG4108KF3 Electron transport protein SCO1 SenC CSW12_16840 ENOG4108RCR degv family CSW12_16855 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CSW12_16865 ENOG4108UT2 hemolysin iii CSW12_16870 ENOG4105E9Q Acyl-transferase CSW12_16880 ENOG4107RVG penicillin-binding protein CSW12_16895 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) CSW12_16910 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 CSW12_16935 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase CSW12_16940 ENOG4105VMP Transcriptional regulator CSW12_16950 ENOG4105KD7 acetyltransferase CSW12_16970 ENOG4105CY2 Citrate transporter CSW12_16975 ENOG4107XGZ Hydrolase CSW12_16995 ENOG4105C8J )-transporter CSW12_17050 ENOG4105EC2 ftsk spoIIIe CSW12_17070 ENOG4105C5S asparaginyl-tRNA synthetase CSW12_17080 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) CSW12_17105 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CSW12_17120 ENOG4105C75 arginyL-tRNA synthetase CSW12_17125 ENOG4107YX5 Pfam:DUF548 CSW12_17160 ENOG4108UUM single-stranded DNA-binding protein CSW12_17175 ENOG4105C5H ABC transporter CSW12_17195 ENOG4105MCT stage V sporulation protein S CSW12_17230 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) CSW12_17235 ENOG4108IFG nitrite reductase, (NAD(P)H) CSW12_17240 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit CSW12_17245 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CSW12_17250 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein CSW12_17255 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein CSW12_17285 ENOG4108ZAF Molybdopterin CSW12_17290 ENOG4105CVM Molybdenum cofactor synthesis domain protein CSW12_17295 ENOG4105D06 uba thif-type nad fad binding protein CSW12_17300 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CSW12_17305 ENOG4107V6Q Cyclic nucleotide-binding domain CSW12_17315 ENOG4105R3A Nitrate reductase CSW12_17320 ENOG4108IUE nitrate reductase beta subunit CSW12_17330 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CSW12_17345 ENOG4108V06 Glutathione peroxidase CSW12_17355 ENOG4105CNW domain protein CSW12_17370 ENOG4105EMN RNA polymerase sigma factor CSW12_17375 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein CSW12_17385 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily CSW12_17410 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CSW12_17435 ENOG4105KBJ sporulation protein ytfj CSW12_17475 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) CSW12_17505 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CSW12_17510 ENOG4108JYZ YitT family CSW12_17515 ENOG41087PP glycosyltransferase MGT family CSW12_17530 ENOG4107RBS Methyltransferase CSW12_17535 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CSW12_17545 ENOG4105D94 Major Facilitator Superfamily CSW12_17550 ENOG41082F9 transcriptional regulator CSW12_17565 ENOG4108ZRV stage ii sporulation protein p CSW12_17595 ENOG4108VXD carboxy-peptidase CSW12_17610 ENOG4108ZRV stage ii sporulation protein p CSW12_17630 ENOG4108Z7R Chaperone CsaA CSW12_17660 ENOG4105C37 (CBS) domain CSW12_17665 ENOG4105SXS Protein of unknown function (DUF456) CSW12_17685 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CSW12_17695 ENOG4108S4H thioesterase Superfamily protein CSW12_17705 ENOG4108PJD permease CSW12_17720 ENOG4107T5V SNARE associated Golgi CSW12_17765 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CSW12_17775 ENOG4105K4T epimerase CSW12_17785 ENOG4105DSE periplasmic solute binding protein CSW12_17795 ENOG4105CKI cobalamin synthesis protein CSW12_17800 ENOG4107QM2 Aldo Keto reductase CSW12_17835 ENOG4108WPJ Ferritin-like domain CSW12_17840 ENOG4108K88 Membrane CSW12_17860 ENOG4105C8Q Methyl-accepting chemotaxis CSW12_17885 ENOG4107XZQ multidrug resistance protein CSW12_17890 ENOG4105CPC Aldo Keto reductase CSW12_17895 ENOG4105YVS arsR family transcriptional regulator CSW12_17905 ENOG4105KRN Transcriptional regulator, abrb family CSW12_17955 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CSW12_17960 ENOG4108ZUB Lysine exporter protein (Lyse ygga) CSW12_17970 ENOG4105YWU small acid-soluble spore protein CSW12_17975 ENOG4108WBH protein TIM barrel CSW12_17990 ENOG4105CEY Amp-dependent synthetase and ligase CSW12_17995 ENOG4105DUU IucA IucC family protein CSW12_18005 ENOG4105VRR gCN5-related N-acetyltransferase CSW12_18010 ENOG4105KT7 mgtC SapB transporter CSW12_18025 ENOG4105BZU Histidine kinase CSW12_18030 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CSW12_18040 ENOG4108KGH TRANSCRIPTIONal CSW12_18055 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) CSW12_18065 ENOG4105D6E homoserine dehydrogenase CSW12_18085 ENOG4108ZJ4 polysaccharide deacetylase CSW12_18090 ENOG41075D4 Aminoglycoside 6-adenylyltransferase CSW12_18105 ENOG4105BZU Histidine kinase CSW12_18110 ENOG4105EFI regulatoR CSW12_18165 ENOG4108UT6 Transferase hexapeptide repeat containing protein CSW12_18175 ENOG4105K64 Glycosyl transferase, family 2 CSW12_18185 ENOG4108JJ8 (ABC) transporter CSW12_18190 ENOG4108JJ9 ABC, transporter CSW12_18195 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CSW12_18200 ENOG4105C4M (Ubiquinol oxidase) subunit I CSW12_18220 ENOG4105MDS 4-oxalocrotonate tautomerase CSW12_18230 ENOG4105SKE transcriptional Regulator LysR family CSW12_18240 ENOG4105C32 Amino acid ABC transporter (Permease) CSW12_18245 ENOG4108IV0 ABC, transporter CSW12_18250 ENOG4105C0Z ABC transporter CSW12_18260 ENOG4105CKI cobalamin synthesis protein CSW12_18275 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CSW12_18280 ENOG4106F5Q Membrane CSW12_18285 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CSW12_18295 ENOG4108TVJ Nitroreductase CSW12_18300 ENOG4107ZXU DSBA oxidoreductase CSW12_18305 ENOG4108Z40 Transcriptional regulator CSW12_18310 ENOG4105GZI Transcriptional regulator CSW12_18315 ENOG4107RT3 EamA-like transporter family CSW12_18320 ENOG4105KTB nuclear export factor GLE1 CSW12_18325 ENOG4108T5E Copper resistance protein CSW12_18375 ENOG4107R16 Multicopper oxidase CSW12_18385 ENOG4107RAQ aminopeptidase CSW12_18405 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) CSW12_18410 ENOG4105D9N nucleoside CSW12_18420 ENOG4107RHR regulatoR CSW12_18435 ENOG4105K8R UPF0145 protein CSW12_18445 ENOG410849A acetyltransferase, (GNAT) family CSW12_18495 ENOG4105C0X amino acid CSW12_18500 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) CSW12_18515 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) CSW12_18520 ENOG41068WN CSW12_18570 ENOG4108IND Tetr family transcriptional regulator CSW12_18575 ENOG4105EQ0 Major Facilitator superfamily CSW12_18580 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) CSW12_18595 ENOG4105CYC Transferase CSW12_18600 ENOG4105DY9 regulatoR CSW12_18610 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b CSW12_18615 ENOG4105C6X Major Facilitator CSW12_18635 ENOG4105C7B Threonine dehydratase CSW12_18640 ENOG4105C01 Dihydroxy-acid dehydratase CSW12_18645 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CSW12_18655 ENOG4105C7K acetolactate synthase CSW12_18660 ENOG4105CM2 brancheD-chain amino acid aminotransferase CSW12_18665 ENOG4105CHR reductase CSW12_18670 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CSW12_18700 ENOG4105H67 Protein of unknown function (DUF421) CSW12_18705 ENOG4105X5K response regulator receiver protein CSW12_18720 ENOG4105C8J )-transporter CSW12_18740 ENOG4105C6T cysteine synthase CSW12_18745 ENOG4105EU0 Major facilitator Superfamily CSW12_18750 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CSW12_18760 ENOG4105DXI Major Facilitator superfamily CSW12_18770 ENOG4105U3E Transcriptional regulator CSW12_18775 ENOG4105CSR polyphosphate kinase 2 CSW12_18790 ENOG4105FVX CSW12_18855 ENOG4105C6K Malic enzyme CSW12_18860 ENOG4108IJ0 Aspartate ammonia-lyase CSW12_18870 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) CSW12_18890 ENOG4105CJ1 ABC, transporter CSW12_18930 ENOG4106BRA Membrane CSW12_18950 ENOG4107JM4 Tetratricopeptide repeat CSW12_18965 ENOG4107QIV Cytochrome c biogenesis protein CSW12_18985 ENOG4105EC3 peptidase S51, dipeptidase E CSW12_18990 ENOG4107QJQ Mate efflux family protein CSW12_19005 ENOG4105C9Q fumarate hydratase class II CSW12_19015 ENOG4105VUF Transcriptional regulator CSW12_19020 ENOG4105DFD Na H antiporter CSW12_19035 ENOG4108PJD permease CSW12_19045 ENOG4105CKI cobalamin synthesis protein CSW12_19055 ENOG4108UZ3 Transporter CSW12_19060 ENOG4105DRR Transcriptional regulator, GntR family CSW12_19070 ENOG4105PGM cation diffusion facilitator family transporter CSW12_19090 ENOG4105CAQ asparagine synthetase CSW12_19110 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) CSW12_19165 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component CSW12_19175 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CSW12_19180 ENOG4105DUM transcriptional regulator, lysR family CSW12_19205 ENOG4105KAC Antibiotic biosynthesis monooxygenase CSW12_19245 ENOG4105CPU Monooxygenase CSW12_19250 ENOG4105KTQ flagellar basal-body rod protein CSW12_19255 ENOG4105FZW flagellar biosynthesis regulator FlhF CSW12_19260 ENOG4105D7B Flagellar biosynthesis protein flha CSW12_19265 ENOG4105D00 flagellar biosynthetic protein flhB CSW12_19275 ENOG4105VS8 Flagellar biosynthetic protein fliq CSW12_19280 ENOG4105CN7 Flagellar biosynthetic protein FliP CSW12_19290 ENOG4105DD5 Flagellar motor switch protein CSW12_19295 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CSW12_19305 ENOG4105E4C Lytic transglycosylase catalytic CSW12_19310 ENOG4105I03 Flagellin CSW12_19315 ENOG4105I03 Flagellin CSW12_19320 ENOG4105I03 Flagellin CSW12_19325 ENOG4105I03 Flagellin CSW12_19335 ENOG4107R88 Chemotaxis protein (CheV) CSW12_19350 ENOG4105BZE flagellar hook protein, FlgE CSW12_19380 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CSW12_19385 ENOG4107U2N Flagellar M-ring protein CSW12_19390 ENOG41075Z6 flagellar hook-basal body complex protein fliE CSW12_19395 ENOG4108ZC9 flagellar basal-body rod protein flgc CSW12_19400 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) CSW12_19415 ENOG4107TPX flagellar hook-associated CSW12_19420 ENOG4105DTJ flagellar hook-associated protein CSW12_19445 ENOG4105BZU Histidine kinase CSW12_19460 ENOG4105DD5 Flagellar motor switch protein CSW12_19465 ENOG4105CBS Chea signal transduction histidine kinase CSW12_19470 ENOG4107YTP response regulator receiver protein CSW12_19475 ENOG4105ER2 Ompa motb domain protein CSW12_19480 ENOG4107R0U MotA TolQ exbB proton channel CSW12_19490 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CSW12_19540 ENOG41080C8 DUF218 domain CSW12_19545 ENOG4105H67 Protein of unknown function (DUF421) CSW12_19555 ENOG4108Z5V transcriptional regulator, merr family CSW12_19560 ENOG4107RWR Sodium hydrogen exchanger CSW12_19570 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CSW12_19635 ENOG41081VK Ribonuclease CSW12_19655 ENOG4108SZE gCN5-related N-acetyltransferase CSW12_19670 ENOG4105CPK Glycosyl transferase (Group 1 CSW12_19755 ENOG4105KHC sulfurtransferase CSW12_19765 ENOG4108W0I acetyltransferase CSW12_19775 ENOG410890F Dynamin family CSW12_19785 ENOG4105DHF Membrane CSW12_19790 ENOG4105C2W permease CSW12_19795 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) CSW12_19800 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CSW12_19810 ENOG4105CTD carboxy-peptidase CSW12_19815 ENOG4105DVT helicase CSW12_19825 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) CSW12_19840 ENOG4106F55 Protein of unknown function (DUF1273) CSW12_19885 ENOG4105BZ4 penicillin-binding protein CSW12_19895 ENOG4105CSM endonuclease III CSW12_19915 ENOG4105YAC CSW12_19920 ENOG4105DVT helicase CSW12_19935 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) CSW12_19960 ENOG4105CPK Glycosyl transferase (Group 1 CSW12_19965 ENOG4105FJR Lmbe family CSW12_19980 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase CSW12_19990 ENOG4108JYZ YitT family CSW12_20030 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) CSW12_20035 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) CSW12_20050 ENOG41068YB TPR repeat-containing protein CSW12_20065 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CSW12_20070 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) CSW12_20075 ENOG4105EAH synthase CSW12_20085 ENOG4105XXQ heptaprenyl diphosphate synthase component I CSW12_20100 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) CSW12_20120 ENOG4108YM7 Gcn5-related n-acetyltransferase CSW12_20140 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CSW12_20145 ENOG4108R6K riboflavin synthase, subunit alpha CSW12_20170 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CSW12_20175 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CSW12_20190 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CSW12_20205 ENOG4105DFD Na H antiporter CSW12_20210 ENOG4105CGH 5'-nucleotidase CSW12_20235 ENOG4105DBV ornithine carbamoyltransferase CSW12_20250 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) CSW12_20265 ENOG4108IXY short-chain dehydrogenase reductase CSW12_20270 ENOG41069FQ Metallo-beta-lactamase superfamily CSW12_20275 ENOG4105II7 pyrroline-5-carboxylate reductase CSW12_20280 ENOG4105EJQ L-serine dehydratase CSW12_20315 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic CSW12_20340 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CSW12_20345 ENOG4105D9U N-acetyltransferase CSW12_20360 ENOG4108VZI ErfK ybiS ycfS ynhG family protein CSW12_20365 ENOG4108QEG Membrane CSW12_20370 ENOG4105CDA abc transporter atp-binding protein CSW12_20375 ENOG4105E5Q amino acid AbC transporter CSW12_20380 ENOG4108HW3 (ABC) transporter CSW12_20390 ENOG4105G7B Protein of unknown function (DUF2992) CSW12_20400 ENOG4108QY0 Membrane CSW12_20415 ENOG4105C7S Dehydrogenase CSW12_20420 ENOG4105CPP Dehydrogenase, E1 component CSW12_20435 ENOG4105CKM Branched-chain carboxylic acid kinase CSW12_20440 ENOG4107RDP Dehydrogenase CSW12_20455 ENOG4108JUB Transcriptional regulator CSW12_20465 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CSW12_20485 ENOG4107QQR Sporulation CSW12_20495 ENOG4105S1Z Stage IV sporulation protein B CSW12_20500 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CSW12_20505 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) CSW12_20510 ENOG4105DX0 Hemolysin A CSW12_20520 ENOG4105CTB Polyprenyl synthetase CSW12_20535 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) CSW12_20545 ENOG4108ZSR alkaline shock protein CSW12_20550 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CSW12_20575 ENOG410644B Stage III sporulation protein af CSW12_20585 ENOG4105KQ4 Stage iii sporulation protein ad CSW12_20590 ENOG4108CQH stage III sporulation protein AC CSW12_20595 ENOG4105KR5 Stage iii sporulation protein CSW12_20600 ENOG4105CD2 stage iii sporulation protein aa CSW12_20625 ENOG4105DC7 peptidase M24 CSW12_20630 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) CSW12_20640 ENOG4105CBJ Metal-dependent enzyme CSW12_20650 ENOG4107YBY Hydrolase CSW12_20680 ENOG41082GG biotin lipoate A B protein ligase CSW12_20685 ENOG4105WZW rhodanese family CSW12_20710 ENOG41080TC multidrug resistance protein CSW12_20745 ENOG4105CJ1 ABC, transporter CSW12_20750 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family CSW12_20785 ENOG4105C0D helicase CSW12_20885 ENOG4107R6U sodium dicarboxylate symporter CSW12_20925 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CSW12_20930 ENOG4105C3R Methionine synthase CSW12_20940 ENOG4105C28 cystathionine CSW12_20945 ENOG4105C28 cystathionine CSW12_20965 ENOG4105C5X domain protein CSW12_20975 ENOG4105DKQ ROK family CSW12_20985 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase CSW12_21000 ENOG4108UTW Plays a role in the regulation of phosphate uptake CSW12_21005 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CSW12_21010 ENOG4105C8U phosphate abc transporter CSW12_21015 ENOG4105C8U phosphate abc transporter CSW12_21020 ENOG4105EXS phosphate abc transporter CSW12_21025 ENOG4107RF6 penicillin-binding protein CSW12_21035 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CSW12_21060 ENOG4105N80 Ferric uptake regulator, Fur family CSW12_21070 ENOG4105FDK ABC transporter CSW12_21075 ENOG4108JYZ YitT family CSW12_21080 ENOG41069ZM Protein of unknown function (DUF2624) CSW12_21105 ENOG4105EGD dinuclear metal center protein, YbgI family CSW12_21120 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CSW12_21125 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CSW12_21160 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) CSW12_21165 ENOG4105KG3 cytidine deaminase CSW12_21170 ENOG4107YR5 Diacylglycerol kinase CSW12_21175 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) CSW12_21180 ENOG4105CTJ Metal Dependent Phosphohydrolase CSW12_21185 ENOG4105C9A Phoh family CSW12_21195 ENOG41068P3 sporulation protein YqfC CSW12_21205 ENOG4105KTH gatB Yqey CSW12_21220 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CSW12_21225 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CSW12_21255 ENOG4105CSA Coproporphyrinogen iii oxidase CSW12_21260 ENOG4105KVH Transcriptional regulator CSW12_21285 ENOG4105TQK DNA polymerase iii, delta' subunit CSW12_21295 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 CSW12_21300 ENOG4108UK2 deaminase CSW12_21325 ENOG4105DXX methyltransferase CSW12_21335 ENOG4108WF2 Metal Dependent Phosphohydrolase CSW12_21345 ENOG410812S Rna-binding protein CSW12_21355 ENOG4105CQW ribosome biogenesis GTPase YqeH CSW12_21360 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase CSW12_21375 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CSW12_21395 ENOG4108TVJ Nitroreductase CSW12_21410 ENOG4105G6Z alkaline phosphatase CSW12_21415 ENOG4105KEG ribosomal-protein-alanine acetyltransferase CSW12_21425 ENOG4108MUZ hydrolase CSW12_21460 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin CSW12_21465 ENOG4105MIR Phenylalanine 4-monooxygenase CSW12_21475 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase CSW12_21520 ENOG4105S6R Iron-hydroxamate transporter permease subunit CSW12_21525 ENOG4108V5C ABC transporter CSW12_21540 ENOG4108EKI Dehydrogenase CSW12_21545 ENOG4105C28 cystathionine CSW12_21575 ENOG4107XRG penicillin-binding protein CSW12_21580 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) CSW12_21590 ENOG4105CFP Peptidase U32 CSW12_21595 ENOG4105XYU peptidase (U32 family) CSW12_21600 ENOG4108VQJ O-methyltransferase CSW12_21605 ENOG4105HHA aminodeoxychorismate lyase CSW12_21625 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CSW12_21635 ENOG4105C02 permease CSW12_21650 ENOG41060CR CSW12_21655 ENOG4105C7H Helicase, RecD TraA family CSW12_21665 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) CSW12_21670 ENOG4105C3J Cysteine desulfurase CSW12_21680 ENOG4105D1H recombination factor protein RarA CSW12_21685 ENOG4108VCI transcription factor, rsfa family CSW12_21700 ENOG4105CUZ uba thif-type nad fad binding protein CSW12_21710 ENOG4105CUT histidyl-tRNA synthetase CSW12_21720 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) CSW12_21725 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CSW12_21735 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CSW12_21740 ENOG41076HS cation diffusion facilitator family transporter CSW12_21745 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CSW12_21755 ENOG4105CKP Polysaccharide Biosynthesis Protein CSW12_21760 ENOG4108QG2 Membrane CSW12_21770 ENOG4105VIE preprotein translocase, subunit YajC CSW12_21785 ENOG41061AI Protein of unknown function (DUF2905) CSW12_21800 ENOG4108HUF Transporter CSW12_21830 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase CSW12_21835 ENOG4108IYU L-aspartate oxidase CSW12_21850 ENOG4108RPX mosc domain containing protein CSW12_21855 ENOG4105CQC Prephenate dehydratase CSW12_21870 ENOG4105C19 ABC transporter CSW12_21875 ENOG4105EWM Histidine kinase CSW12_21885 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control CSW12_21900 ENOG4105X36 (ribosomal) protein CSW12_21910 ENOG4105C03 ribonuclease CSW12_21925 ENOG4107QMS site-determining protein CSW12_21940 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) CSW12_21945 ENOG4105DFF Rod shape-determining protein mreb CSW12_21970 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CSW12_21975 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) CSW12_21985 ENOG41068KH stage VI sporulation protein D CSW12_21995 ENOG4105D52 delta-aminolevulinic acid dehydratase CSW12_22020 ENOG4105K56 Transcriptional regulator CSW12_22045 ENOG4108IUQ atp-dependent protease CSW12_22075 ENOG4108QCI YvbH-like oligomerisation region CSW12_22105 ENOG4105M59 Phosphodiesterase, mj0936 family CSW12_22110 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CSW12_22120 ENOG4108XJQ germination protein CSW12_22130 ENOG4108PCX Major Facilitator CSW12_22140 ENOG4105KBX Transcriptional regulator, TetR family CSW12_22150 ENOG4105PFC Transcriptional regulator CSW12_22160 ENOG4105DZC cytosine deaminase CSW12_22165 ENOG41067S9 phage shock protein C, PspC CSW12_22170 ENOG4108JCI Transcriptional regulator CSW12_22180 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CSW12_22185 ENOG4108Z40 Transcriptional regulator CSW12_22190 ENOG4105RHA ABC transporter, permease CSW12_22195 ENOG4108IUX (ABC) transporter CSW12_22200 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family CSW12_22205 ENOG4105ER2 Ompa motb domain protein CSW12_22210 ENOG4105E14 MotA TolQ exbB proton channel CSW12_22220 ENOG4108VXD carboxy-peptidase CSW12_22230 ENOG4105E33 succinate dehydrogenase CSW12_22240 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit CSW12_22250 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CSW12_22255 ENOG4105K63 Thioredoxin CSW12_22260 ENOG4105C10 Electron transfer flavoprotein CSW12_22265 ENOG4105BZJ Electron transfer flavoprotein CSW12_22270 ENOG41060WC Enoyl-CoA hydratase CSW12_22275 ENOG4107Z3H Transcriptional regulator, TetR family CSW12_22280 ENOG4105CEY Amp-dependent synthetase and ligase CSW12_22295 ENOG4105J76 Periplasmic binding protein CSW12_22300 ENOG4105S6R Iron-hydroxamate transporter permease subunit CSW12_22355 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CSW12_22370 ENOG4105DR4 Methyltransferase CSW12_22380 ENOG4105KFN sortase, SrtB family CSW12_22385 ENOG4105E0A ABC, transporter CSW12_22400 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) CSW12_22410 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) CSW12_22420 ENOG4105FE9 pseudouridine synthase CSW12_22435 ENOG4105DCG PHP domain protein CSW12_22450 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CSW12_22470 ENOG4105C5S asparaginyl-tRNA synthetase CSW12_22475 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) CSW12_22485 ENOG4108RWN rrna methyltransferase CSW12_22515 ENOG4105C0R drug resistance transporter emrb qaca subfamily CSW12_22520 ENOG4105CW7 secretion protein, HlyD family CSW12_22525 ENOG4108JGH Tetr family transcriptional regulator CSW12_22530 ENOG4105CN9 Peptidase m42 family protein CSW12_22550 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) CSW12_22555 ENOG4105C22 threonyL-tRNA synthetase CSW12_22560 ENOG4108TDW sporulation protein YtxC CSW12_22585 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) CSW12_22595 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CSW12_22600 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) CSW12_22610 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CSW12_22615 ENOG4105C2M dna polymerase I CSW12_22620 ENOG4105BZU Histidine kinase CSW12_22625 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CSW12_22650 ENOG4108HMX isocitrate dehydrogenase (NADP) CSW12_22655 ENOG4105BZN citrate synthase CSW12_22670 ENOG4108REF Sporulation integral membrane protein ytvi CSW12_22675 ENOG4105FS0 cytoplasmic membrane protein CSW12_22700 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family CSW12_22705 ENOG4105C6K Malic enzyme CSW12_22710 ENOG4105C0B DNA polymerase III (alpha subunit) CSW12_22715 ENOG4105VV2 CSW12_22725 ENOG4105SFS phosphoesterase RecJ domain protein CSW12_22755 ENOG4105DC7 peptidase M24 CSW12_22785 ENOG4105Z7P Acetyltransferase (GNAT) family CSW12_22790 ENOG41082W1 Cupin 2, conserved barrel domain protein CSW12_22810 ENOG4107YZX Universal stress protein CSW12_22855 ENOG4108JYZ YitT family CSW12_22875 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) CSW12_22885 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) CSW12_22890 ENOG4105KBJ sporulation protein ytfj CSW12_22910 ENOG4105EFZ amidohydrolase CSW12_22915 ENOG410607W Transposase CSW12_22930 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CSW12_22955 ENOG4105RQF LysR family Transcriptional regulator CSW12_22965 ENOG4105U5Y Transcriptional regulator CSW12_22975 ENOG4105C28 cystathionine CSW12_23015 ENOG4105EMN RNA polymerase sigma factor CSW12_23025 ENOG4108UW5 maltose o-acetyltransferase CSW12_23035 ENOG4105F1V Acetoin utilization protein CSW12_23040 ENOG4105W87 Cbs domain CSW12_23045 ENOG4105DGU Histone deacetylase CSW12_23060 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CSW12_23065 ENOG4105BZU Histidine kinase CSW12_23070 ENOG4107SNB ankyrin repeat protein YahD CSW12_23075 ENOG4105EP9 oxidoreductase CSW12_23100 ENOG4105ETE Transcriptional regulator (LacI family CSW12_23115 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase CSW12_23120 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase CSW12_23140 ENOG4105C88 aminopeptidase CSW12_23165 ENOG4108IPJ Membrane CSW12_23200 ENOG4108VDD TRNA binding domain protein CSW12_23230 ENOG4105C8F Beta-lactamase domain protein CSW12_23235 ENOG410607W Transposase CSW12_23250 ENOG4108V15 phosphotransferase enzyme family CSW12_23255 ENOG4108IUM Glycogen debranching enzyme CSW12_23265 ENOG4107QSE Dipeptidase CSW12_23270 ENOG4105YW5 deoR family transcriptional regulator CSW12_23285 ENOG4105CBX hi0933 family CSW12_23330 ENOG4108VJ1 Transcriptional regulator (CarD family CSW12_23335 ENOG4107EXU Short-chain dehydrogenase reductase Sdr CSW12_23340 ENOG4105CSC Glucose uptake protein CSW12_23355 ENOG4108ZAF Molybdopterin CSW12_23360 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein CSW12_23365 ENOG4105CVM Molybdenum cofactor synthesis domain protein CSW12_23375 ENOG4105D06 uba thif-type nad fad binding protein CSW12_23380 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CSW12_23405 ENOG41085GJ domain protein CSW12_23415 ENOG4105DWV Homoserine O-trans-acetylase CSW12_23425 ENOG4108B31 Spore germination protein CSW12_23450 ENOG4105C8T Leucyl-tRNA synthetase CSW12_23455 ENOG410605W Major Facilitator CSW12_23460 ENOG4107S91 Sodium hydrogen exchanger CSW12_23465 ENOG4105NCW Trka-c domain protein CSW12_23485 ENOG4105C19 ABC transporter CSW12_23505 ENOG4105N5T Radical SAM Protein CSW12_23545 ENOG4105E8V Alpha Beta Hydrolase Fold protein CSW12_23550 ENOG4108Z0R Transferase CSW12_23555 ENOG4105YVM Phosphoesterase, PA-phosphatase related CSW12_23560 ENOG4105BZF Glycosyl transferase (Group 1 CSW12_23570 ENOG4105EPU Molybdenum cofactor synthesis domain protein CSW12_23670 ENOG4105BZU Histidine kinase CSW12_23675 ENOG4105BZU Histidine kinase CSW12_23680 ENOG4107S9D Alpha beta hydrolase CSW12_23685 ENOG4107T7U Sulfatase CSW12_23700 ENOG4105D2X ABC transporter substrate-binding protein CSW12_23710 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component CSW12_23775 ENOG4108V2W Carbonate dehydratase CSW12_23780 ENOG4105C4M (Ubiquinol oxidase) subunit I CSW12_23785 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CSW12_23830 ENOG41087YS Phage shock protein A CSW12_23855 ENOG4105N67 Proton-coupled thiamine transporter YuaJ CSW12_23860 ENOG4105BZU Histidine kinase CSW12_23865 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CSW12_23890 ENOG4108UGV hypoxanthine phosphoribosyltransferase CSW12_23895 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) CSW12_23925 ENOG4107ZTW SNARE associated Golgi CSW12_23940 ENOG4105C19 ABC transporter CSW12_23945 ENOG41086D8 Transcriptional regulator CSW12_23960 ENOG41082BM Transcriptional regulator, arsr family CSW12_24010 ENOG4105C6Z Gluconate CSW12_24015 ENOG4105FDP GntR family transcriptional regulator CSW12_24035 ENOG41069H0 dihydroorotase EC 3.5.2.3 CSW12_24060 ENOG4105DTQ mandelate racemase muconate lactonizing CSW12_24065 ENOG4105CEY Amp-dependent synthetase and ligase CSW12_24080 ENOG4108IPT Naphthoate synthase CSW12_24085 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) CSW12_24095 ENOG4105E4F Isochorismate synthase CSW12_24100 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CSW12_24110 ENOG4105VEQ Cold shock protein CSW12_24155 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) CSW12_24160 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) CSW12_24170 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin CSW12_24185 ENOG4108Q5F Tetr family transcriptional regulator CSW12_24325 ENOG4105KT7 mgtC SapB transporter CSW12_24330 ENOG4107PBV potassium channel CSW12_24350 ENOG4105WG9 Conserved Protein CSW12_24360 ENOG4105CHM Aminotransferase CSW12_24365 ENOG4108ZB6 transcriptional regulator AsnC family CSW12_24370 ENOG4105C5I Dehydrogenase CSW12_24375 ENOG4108MUZ hydrolase CSW12_24385 ENOG4105C87 Aminotransferase class I and II CSW12_24395 ENOG4105Y38 Kinase-associated protein B CSW12_24405 ENOG4107R3E Citrate transporter CSW12_24425 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) CSW12_24430 ENOG4105KA0 thioesterase Superfamily protein CSW12_24445 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CSW12_24465 ENOG41069ER domain protein CSW12_24480 ENOG4105CEP NADH dehydrogenase CSW12_24510 ENOG4105EWC Purine nucleoside phosphorylase CSW12_24520 ENOG4108VQJ O-methyltransferase CSW12_24545 ENOG4108YX9 iron--sulfur cluster insertion protein erpA CSW12_24570 ENOG4108JJA ABC, transporter CSW12_24575 ENOG4105C4B ABC transporter, permease CSW12_24580 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA CSW12_24610 ENOG41083MR nifu domain-containing protein CSW12_24625 ENOG4108W5N phosphatidylglycerophosphatase a CSW12_24645 ENOG4105DAX Pfam:DUF2983 CSW12_24655 ENOG4105DYS nad(p)h dehydrogenase (quinone) CSW12_24660 ENOG4105D4U had-superfamily hydrolase, subfamily iia CSW12_24675 ENOG4105CBT Fructose-1,6-bisphosphatase CSW12_24695 ENOG4105MMD transcriptional regulator CSW12_24700 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) CSW12_24705 ENOG4107TXC Transcriptional regulator CSW12_24710 ENOG41090T1 Membrane CSW12_24735 ENOG4105FAA peptidase M23 CSW12_24740 ENOG4108YTE sporulation protein YunB CSW12_24745 ENOG4105KZD Domain of unknown function (DUF1805) CSW12_24760 ENOG4105DIW FeS assembly protein SUFB CSW12_24765 ENOG4108UNV SUF system FeS assembly protein, NifU family CSW12_24770 ENOG4105C9B Cysteine desulfurase CSW12_24775 ENOG4105JRK feS assembly protein SufD CSW12_24780 ENOG4105C3K feS assembly ATPase SufC CSW12_24785 ENOG4105D01 (LipO)protein CSW12_24790 ENOG4105D01 (LipO)protein CSW12_24795 ENOG4108UMI ABC transporter, permease CSW12_24800 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CSW12_24830 ENOG41080E8 Transcriptional regulator, Spx MgsR family CSW12_24850 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CSW12_24875 ENOG4108W8B Beta-lactamase domain protein CSW12_24880 ENOG4105C1G acyl-Coa dehydrogenase CSW12_24885 ENOG4105CHU acetyl-coa acetyltransferase CSW12_24900 ENOG4105DZ1 carboxypeptidase CSW12_24920 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer CSW12_24935 ENOG4108SUT Major Facilitator Superfamily CSW12_24940 ENOG4107R7I amino acid CSW12_24955 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CSW12_24965 ENOG4107AYK membrAne CSW12_25005 ENOG4107ZTW SNARE associated Golgi CSW12_25015 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein CSW12_25020 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CSW12_25025 ENOG4105BZU Histidine kinase CSW12_25040 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) CSW12_25055 ENOG4105C8Q Methyl-accepting chemotaxis CSW12_25060 ENOG4105VG1 fes assembly suf system protein CSW12_25065 ENOG4105D4Y metalloprotease CSW12_25070 ENOG4105C2I pirin domain protein CSW12_25085 ENOG4107T5V SNARE associated Golgi CSW12_25090 ENOG4107S91 Sodium hydrogen exchanger CSW12_25095 ENOG4105NCW Trka-c domain protein CSW12_25110 ENOG4108RMU ferritin dps family protein CSW12_25125 ENOG4108URH decarboxylase CSW12_25135 ENOG41090A1 ferritin CSW12_25150 ENOG4105D9N nucleoside CSW12_25155 ENOG4105D9N nucleoside CSW12_25170 ENOG4108RYK Nad-dependent epimerase dehydratase CSW12_25195 ENOG4105CV8 reductase CSW12_25200 ENOG4105F27 Major Facilitator CSW12_25210 ENOG4105KVH Transcriptional regulator CSW12_25225 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CSW12_25230 ENOG4105D4A Cell wall formation (By similarity) CSW12_25250 ENOG4105WMR Protein CrcB homolog CSW12_25255 ENOG4105WMR Protein CrcB homolog CSW12_25275 ENOG4105C5H ABC transporter CSW12_25280 ENOG4108MK9 spermidine N(1)-acetyltransferase CSW12_25285 ENOG4108VY7 phosphate-starvation-inducible protein PsiE CSW12_25295 ENOG4108W2Y isochorismatase CSW12_25315 ENOG4108V2W Carbonate dehydratase CSW12_25320 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) CSW12_25335 ENOG4108IPW abc transporter atp-binding protein CSW12_25340 ENOG4105CM4 permease protein CSW12_25370 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CSW12_25380 ENOG4105XZU Preprotein translocase, subunit SecG CSW12_25385 ENOG41067MG lrgb family CSW12_25435 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CSW12_25450 ENOG4108IUX (ABC) transporter CSW12_25455 ENOG4105BZU Histidine kinase CSW12_25480 ENOG41090VF Stage v sporulation protein ac CSW12_25485 ENOG4105CZ3 stage V sporulation protein ad CSW12_25500 ENOG4108QY0 Membrane CSW12_25505 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CSW12_25515 ENOG4105KRI phosphocarrier protein (HPr CSW12_25525 ENOG4105CHW UPF0052 protein CSW12_25530 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) CSW12_25535 ENOG4108Z4K mutator MutT protein CSW12_25545 ENOG4105C3M thioredoxin reductase CSW12_25555 ENOG4108S4C acetyltransferase CSW12_25575 ENOG41086DT Membrane protein of unknown function CSW12_25580 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CSW12_25600 ENOG4107TXC Transcriptional regulator CSW12_25630 ENOG4105DUM transcriptional regulator, lysR family CSW12_25640 ENOG4108WS4 fmn reductase CSW12_25645 ENOG4105C5H ABC transporter CSW12_25655 ENOG4105BZ1 (ABC) transporter CSW12_25665 ENOG4105CN1 protease CSW12_25670 ENOG4105CRP Part of the ABC transporter FtsEX involved in CSW12_25675 ENOG4105CAK Cell division ATP-binding protein ftsE CSW12_25705 ENOG4108RDQ ABC transporter CSW12_25735 ENOG4105MS2 ribosomal subunit Interface protein CSW12_25740 ENOG4105VEQ Cold shock protein CSW12_25745 ENOG41081UC Inherit from COG: Competence protein CSW12_25760 ENOG4105KVH Transcriptional regulator CSW12_25775 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CSW12_25780 ENOG4108KGH TRANSCRIPTIONal CSW12_25785 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CSW12_25795 ENOG4105ESV Glycosyl transferase, family 4 CSW12_25805 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CSW12_25825 ENOG4105F8D glycoside hydrolase family 4 CSW12_25830 ENOG4105VCP PTS System CSW12_25835 ENOG4105CK1 PTS System CSW12_25845 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) CSW12_25850 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) CSW12_25855 ENOG4105VCP PTS System CSW12_25865 ENOG4105VZJ PTS System CSW12_25885 ENOG4105ECB domain protein CSW12_25890 ENOG4107RSM transcriptional regulator CSW12_25920 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) CSW12_25945 ENOG4105DAA L-lactate CSW12_25950 ENOG410607W Transposase CSW12_25960 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) CSW12_25975 ENOG4105E0M Sulfatase CSW12_26005 ENOG4107R8N Glycosyl transferase, family 2 CSW12_26015 ENOG4105C94 Transporter CSW12_26025 ENOG41069ER domain protein CSW12_26050 ENOG4105KBK Zinc finger, swim domain protein CSW12_26055 ENOG4105C0D helicase CSW12_26085 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CSW12_26095 ENOG4107RBB ABC transporter, permease CSW12_26100 ENOG4105C19 ABC transporter CSW12_26120 ENOG4105CXY transporter CSW12_26135 ENOG4105BZU Histidine kinase CSW12_26140 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CSW12_26145 ENOG4105CMR udp-glucose 4-epimerase CSW12_26155 ENOG4108KGH TRANSCRIPTIONal CSW12_26175 ENOG4107T8Q Glycosyl transferase (Group 1 CSW12_26185 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) CSW12_26190 ENOG4105CPF Cell wall formation (By similarity) CSW12_26195 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CSW12_26205 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CSW12_26210 ENOG4108RB3 Capsular polysaccharide biosynthesis protein CSW12_26215 ENOG4107YJ4 chain length determinant protein CSW12_26220 ENOG4105HTX biosynthesis protein CSW12_26225 ENOG4107YJ4 chain length determinant protein CSW12_26240 ENOG4105MT0 Sporulation transcriptional regulator spoiiid CSW12_26250 ENOG4105FRN stage II sporulation protein CSW12_26265 ENOG4105DY9 regulatoR CSW12_26285 ENOG4106778 Protein of unknown function (DUF1146) CSW12_26290 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CSW12_26295 ENOG4105C8S subunit m CSW12_26300 ENOG4105D65 subunit l CSW12_26325 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CSW12_26330 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CSW12_26340 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CSW12_26345 ENOG4105BZU Histidine kinase CSW12_26400 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) CSW12_26405 ENOG41062M3 atp synthase CSW12_26425 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) CSW12_26435 ENOG4108UIC UPF0340 protein CSW12_26440 ENOG4108YZG isomerase CSW12_26460 ENOG4108VGI doxx family CSW12_26465 ENOG4107XC4 flavin reductase domain protein, FMN-binding CSW12_26480 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CSW12_26490 ENOG4108ZXQ stage ii sporulation protein r CSW12_26495 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CSW12_26500 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) CSW12_26520 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) CSW12_26525 ENOG4105CBT Fructose-1,6-bisphosphatase CSW12_26530 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CSW12_26550 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) CSW12_26565 ENOG4105C1G acyl-Coa dehydrogenase CSW12_26570 ENOG4105C1G acyl-Coa dehydrogenase CSW12_26575 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CSW12_26585 ENOG4105DF6 Fe-S oxidoreductase CSW12_26605 ENOG4105BZU Histidine kinase CSW12_26620 ENOG4105D4Y metalloprotease CSW12_26630 ENOG4105BZU Histidine kinase CSW12_26635 ENOG4105KCT ABC transporter CSW12_26640 ENOG4108M15 ABC transporter CSW12_26645 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) CSW12_26660 ENOG4105IIU Aminopeptidase CSW12_26670 ENOG4105EMN RNA polymerase sigma factor CSW12_26680 ENOG410684U Domain of unknown function (DUF1934) CSW12_26705 ENOG4105CYW agmatinase CSW12_26715 ENOG4105DXB Major Facilitator superfamily CSW12_26720 ENOG4107SWG transcriptional regulator MERR family CSW12_26725 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CSW12_26730 ENOG4105BZ4 penicillin-binding protein CSW12_26735 ENOG4108XFG YwhD family CSW12_26740 ENOG4108Z4T Peptidase M50 CSW12_26745 ENOG41069HH 4-oxalocrotonate tautomerase CSW12_26750 ENOG4105DCI Phosphohydrolase CSW12_26755 ENOG4108MES Periplasmic binding protein CSW12_26760 ENOG4105E0A ABC, transporter CSW12_26765 ENOG4105EHG Permease protein CSW12_26770 ENOG4105DQ5 transport system permease protein CSW12_26780 ENOG4108VCI transcription factor, rsfa family CSW12_26785 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) CSW12_26790 ENOG4108IJ2 phosphate acetyltransferase CSW12_26795 ENOG4107UEZ chlorite dismutase CSW12_26805 ENOG4108VKI Cell wall hydrolase CSW12_26830 ENOG4107SVH Potassium channel protein CSW12_26840 ENOG410667J hydrolase CSW12_26845 ENOG4105VCH membrane CSW12_26855 ENOG4108TU7 Inherit from COG: (ABC) transporter CSW12_26860 ENOG4105CJ1 ABC, transporter CSW12_26865 ENOG41090WU lipolytic protein G-D-S-L family CSW12_26880 ENOG4105D6E homoserine dehydrogenase CSW12_26885 ENOG4105CVG Homoserine O-transsuccinylase CSW12_26905 ENOG4108Y4K DNA-binding transcriptional activator CSW12_26915 ENOG4105WH1 Two component transcriptional regulator luxr family CSW12_26920 ENOG4105BZU Histidine kinase CSW12_26925 ENOG4105DWF phosphomethylpyrimidine kinase CSW12_26930 ENOG4105BZU Histidine kinase CSW12_26935 ENOG4105VCD cytoplasmic protein CSW12_26940 ENOG4105D22 carbon starvation protein CSW12_26945 ENOG4105DY9 regulatoR CSW12_26950 ENOG41079KZ Major Facilitator Superfamily CSW12_26960 ENOG4105CG5 Glycosyl transferase (Group 1 CSW12_26970 ENOG4105EN6 Membrane CSW12_26975 ENOG4106YBV Methyl-accepting chemotaxis CSW12_26985 ENOG4108S4H thioesterase Superfamily protein CSW12_26995 ENOG4105K64 Glycosyl transferase, family 2 CSW12_27005 ENOG4105C5H ABC transporter CSW12_27020 ENOG4105CKK Glycosyl transferase, family 2 CSW12_27025 ENOG41067SE Tetr family transcriptional regulator CSW12_27035 ENOG4105E0X reductase CSW12_27040 ENOG4106F5Q Membrane CSW12_27055 ENOG4108NEV two component transcriptional regulator, LytTR family CSW12_27060 ENOG4108HRK Histidine kinase CSW12_27065 ENOG4107RGD Major Facilitator superfamily CSW12_27085 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CSW12_27095 ENOG4105IW1 AmiS UreI transporter CSW12_27105 ENOG4105CMR udp-glucose 4-epimerase CSW12_27110 ENOG4105DQ6 Transposase CSW12_27115 ENOG4105DQ6 Transposase CSW12_27135 ENOG4105K7K Transcriptional regulator CSW12_27140 ENOG4105BZ1 (ABC) transporter CSW12_27145 ENOG4105CJA serine threonine protein kinase CSW12_27175 ENOG4108UT2 hemolysin iii CSW12_27190 ENOG4105C1J atp-dependent rna helicase CSW12_27195 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) CSW12_27200 ENOG4105DPN Oligoendopeptidase f CSW12_27210 ENOG4105BZU Histidine kinase CSW12_27225 ENOG4105C0H protease CSW12_27230 ENOG4105Q2H domain protein CSW12_27245 ENOG4105BZU Histidine kinase CSW12_27250 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CSW12_27275 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis CSW12_27280 ENOG4105CDU Replicative dna helicase CSW12_27290 ENOG4105BZR domain protein CSW12_27295 ENOG4108XMW Membrane CSW12_27305 ENOG4108UUM single-stranded DNA-binding protein CSW12_27315 ENOG4105C3G gtp-binding protein CSW12_27320 ENOG4105VDK protein, conserved in bacteria CSW12_27325 ENOG4105D8X mechanosensitive ion channel CSW12_27330 ENOG4108ZDA Sporulation protein YyaC CSW12_27335 ENOG4105FA0 parb-like partition protein CSW12_27340 ENOG4107QJE Chromosome Partitioning Protein CSW12_27355 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) CSW12_27360 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) CSW12_27370 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CSW12_27390 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CSW12_27395 ENOG410848D S4 domain protein YaaA CSW12_27410 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CSW12_27445 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CSW12_27480 ENOG4105ZMH deoxynucleoside kinase CSW12_27490 ENOG4105GTG Isochorismatase CSW12_27500 ENOG4108Z6B deaminase CSW12_27510 ENOG4105C6E dna polymerase iii CSW12_27530 ENOG41067KS pro-sigma K processing CSW12_27565 ENOG4105CXN decarboxylase CSW12_27575 ENOG4105FA2 dna polymerase iii CSW12_27580 ENOG4105MA4 psp1 domain protein CSW12_27590 ENOG41060K3 Methyltransferase CSW12_27600 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) CSW12_27605 ENOG4105KRN Transcriptional regulator, abrb family CSW12_27610 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) CSW12_27615 ENOG4105F8V Hydrolase, tatD family CSW12_27620 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) CSW12_27630 ENOG4105XFA sporulation peptidase YabG CSW12_27635 ENOG4105W42 Veg protein CSW12_27650 ENOG4105DFT pur operon repressor CSW12_27655 ENOG4105KME endoribonuclease L-psp CSW12_27670 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CSW12_27675 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) CSW12_27685 ENOG4108JA2 transcriptioN-repair coupling factor CSW12_27690 ENOG4108M14 stage v sporulation protein t CSW12_27700 ENOG4108IY2 MazG family CSW12_27705 ENOG41082I2 s4 domain protein CSW12_27710 ENOG4105VYY sporulation protein yabp CSW12_27725 ENOG41060GV RNA binding s1 domain protein CSW12_27745 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) CSW12_27750 ENOG4108UGV hypoxanthine phosphoribosyltransferase CSW12_27755 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CSW12_27770 ENOG4105C6T cysteine synthase CSW12_27775 ENOG4105CRQ synthase (Component I) CSW12_27780 ENOG4105DDQ anthranilate synthase CSW12_27785 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 CSW12_27790 ENOG4105EEI dihydropteroate synthase CSW12_27795 ENOG4105KRF dihydroneopterin aldolase CSW12_27800 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CSW12_27810 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CSW12_27900 ENOG4108Z0C Uvrb UvrC protein CSW12_27915 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CSW12_27925 ENOG4105CTP PilT protein domain protein CSW12_27945 ENOG4105D7W serine acetyltransferase CSW12_27960 ENOG4105C2N RNA methyltransferase TrmH family group 3 CSW12_27965 ENOG4105M0M Tetracycline resistance protein CSW12_27970 ENOG4105QIV RNA polymerase CSW12_27985 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) CSW12_28005 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) CSW12_28010 ENOG4107Y49 methyltransferase CSW12_28020 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CSW12_28025 ENOG4105XPM ribosomal protein CSW12_28135 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) CSW12_28160 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CSW12_28170 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CSW12_28180 ENOG41067V7 50S ribosomal protein L36 CSW12_28205 ENOG4108JJB ABC transporter CSW12_28210 ENOG4108JJB ABC transporter CSW12_28215 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) CSW12_28220 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) CSW12_28245 ENOG4105D1F ATP-binding protein CSW12_28260 ENOG4108NMV polysaccharide deacetylase CSW12_28345 ENOG4105C8B TIGR00159 family CSW12_28350 ENOG4107U5W ybbr family CSW12_28365 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CSW12_28390 ENOG4108PSK reductase CSW12_28395 ENOG4108UMI ABC transporter, permease CSW12_28400 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CSW12_28405 ENOG4105D01 (LipO)protein CSW12_28410 ENOG4105CB2 alcohol dehydrogenase CSW12_28420 ENOG4105IQ5 FAD linked oxidase domain protein CSW12_28435 ENOG4105C2C drug resistance transporter, Bcr CflA CSW12_28455 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CSW12_28460 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CSW12_28465 ENOG4105C3U ABC transporter CSW12_28470 ENOG4108JQ7 (ABC) transporter CSW12_28490 ENOG4108J59 Extracellular solute-binding protein, family 5 CSW12_28495 ENOG4108J59 Extracellular solute-binding protein, family 5 CSW12_28515 ENOG4106Z1T Nicotinamide Mononucleotide Transporter CSW12_28525 ENOG4105E0C molybdate abc transporter CSW12_28530 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CSW12_28535 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family CSW12_28545 ENOG4105EGI Transcriptional regulator CSW12_28565 ENOG4105F6E Acyl-transferase CSW12_28590 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) CSW12_28610 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) CSW12_28640 ENOG4105C5H ABC transporter CSW12_28655 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein CSW12_28665 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CSW12_28670 ENOG4105C3U ABC transporter CSW12_28675 ENOG4108JQ7 (ABC) transporter CSW12_28680 ENOG410667J hydrolase CSW12_28710 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase CSW12_28715 ENOG4105ERH Fumarylacetoacetate hydrolase CSW12_28725 ENOG4105CUB amino acid CSW12_28730 ENOG4108SC4 )-transporter CSW12_28735 ENOG4105CPF Cell wall formation (By similarity) CSW12_28740 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) CSW12_28765 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein CSW12_28770 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CSW12_28780 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) CSW12_28885 ENOG4105K8N protein family UPF0079, ATPase CSW12_28890 ENOG41072GX Peptidase M22 Glycoprotease CSW12_28895 ENOG410801F ribosomal-protein-alanine acetyltransferase CSW12_28900 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CSW12_28905 ENOG4105C5H ABC transporter CSW12_28920 ENOG4108TYN CAAX amino terminal protease family protein CSW12_28940 ENOG4105C7N Xanthine uracil vitamin C permease CSW12_28950 ENOG4105BZU Histidine kinase CSW12_28980 ENOG4107ZXU DSBA oxidoreductase CSW12_29000 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CSW12_29005 ENOG41062BK proline dehydrogenase CSW12_29075 ENOG4105SX7 Transporter CSW12_29220 ENOG4105DQ6 Transposase CSW12_29345 ENOG4105EKQ RNA-directed DNA polymerase CSW12_29495 ENOG41082J7 Rhodanese domain protein CSW12_29510 ENOG4105MZU cell filamentation protein CSW12_29530 ENOG4105C19 ABC transporter CSW12_29650 ENOG4105DQ6 Transposase CSW12_29750 ENOG4105DQ6 Transposase CSW12_29785 ENOG4107SVN transposase CSW12_29815 ENOG4108IMY Transcriptional regulator CSW12_29950 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family CSW12_29960 ENOG4108B31 Spore germination protein CSW12_29965 ENOG4108NHD germination protein CSW12_29990 ENOG4105CHH sulfate transporter CSW12_29995 ENOG4108V2W Carbonate dehydratase CSW12_30015 ENOG4105EXC Acyl-transferase CSW12_30110 ENOG41082J7 Rhodanese domain protein CSW12_30160 ENOG4105DVF Cytosine-specific methyltransferase CSW12_30190 ENOG4105KRN Transcriptional regulator, abrb family CSW12_30195 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CSW12_30265 ENOG4105CND Glycosyl transferase, family 2 CSW12_30430 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CSW12_30435 ENOG4105KRN Transcriptional regulator, abrb family CSW12_30475 ENOG4105EKQ RNA-directed DNA polymerase CSW12_30525 ENOG4105K4H Nlp p60 protein CSW12_30545 ENOG4107SVN transposase CSW12_30575 ENOG4108IMY Transcriptional regulator CSW12_30595 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CSW12_30635 ENOG4105EKQ RNA-directed DNA polymerase CSW12_30690 ENOG4105G6Z alkaline phosphatase CSW12_30720 ENOG4108NHD germination protein CSW12_30725 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family CSW12_30740 ENOG4105EXC Acyl-transferase CSW12_30765 ENOG4108V2W Carbonate dehydratase CSW12_30770 ENOG4105CHH sulfate transporter CSW12_30895 ENOG4105E3W Two component transcriptional regulator (Winged helix family CSW12_30945 ENOG4108IMY Transcriptional regulator CSW12_31015 ENOG4105E80 TraG TraD family protein CSW12_31120 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CSW12_31135 ENOG4108UUM single-stranded DNA-binding protein CSW12_31140 ENOG4105KRN Transcriptional regulator, abrb family CSW12_31155 ENOG4108B1Q Ribonuclease CSW12_31235 ENOG4105EKQ RNA-directed DNA polymerase CSW12_31270 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)