locus-tag class description BF33_10 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BF33_1005 ENOG4105CJ1 ABC, transporter BF33_1007 ENOG4108PSK reductase BF33_1011 ENOG4108RCM Nitroreductase BF33_1012 ENOG4105KVH Transcriptional regulator BF33_1016 ENOG4108Z66 YbaK ebsC protein BF33_1017 ENOG4105EKQ RNA-directed DNA polymerase BF33_1018 ENOG4108Z4K mutator MutT protein BF33_1019 ENOG4105K59 histidine triad (HIT) protein BF33_1020 ENOG4105EKQ RNA-directed DNA polymerase BF33_1023 ENOG4108IND Tetr family transcriptional regulator BF33_1024 ENOG4105EQ0 Major Facilitator superfamily BF33_1031 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BF33_1038 ENOG4105DYS nad(p)h dehydrogenase (quinone) BF33_1040 ENOG4105CRW Short chain fatty acid transporter BF33_1042 ENOG4105KBX Transcriptional regulator, TetR family BF33_1043 ENOG4105KPY Small multidrug resistance protein BF33_1044 ENOG4105RXJ BF33_1046 ENOG4105CZM Major Facilitator BF33_1047 ENOG4107MII Sugar-specific transcriptional regulator TrmB BF33_1049 ENOG4108ISG Major Facilitator BF33_1057 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF33_1061 ENOG410874W AraC family transcriptional regulator BF33_1062 ENOG41082W1 Cupin 2, conserved barrel domain protein BF33_1065 ENOG4108AEY RNA polymerase sigma factor BF33_1069 ENOG4108JQ1 Dehydrogenase BF33_1072 ENOG4105DVH amino acid BF33_1074 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) BF33_1075 ENOG4105C45 hydrogenase expression formation protein (HypE) BF33_1077 ENOG4108JPW Aminotransferase BF33_1079 ENOG4105EJQ L-serine dehydratase BF33_1080 ENOG4105C44 Serine transporter BF33_1086 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF33_1093 ENOG4105TRI Hydrolase BF33_1099 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BF33_11 ENOG4105CQW ribosome biogenesis GTPase YqeH BF33_1101 ENOG4106P55 Transcriptional regulator BF33_1103 ENOG4107QR9 Iron-sulfur cluster binding protein BF33_1104 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) BF33_1105 ENOG4105DJB Major Facilitator Superfamily BF33_1106 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BF33_1108 ENOG4105BZU Histidine kinase BF33_1111 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BF33_1112 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BF33_1115 ENOG4105JQZ Methyltransferase BF33_1119 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF33_1121 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase BF33_1122 ENOG4108NNI Beta-lactamase domain-containing protein BF33_1127 ENOG4105K6H D-cysteine desulfhydrase BF33_1132 ENOG41062D9 Histidine kinase BF33_1133 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF33_1136 ENOG4105IIP Membrane BF33_1138 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF33_1139 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BF33_1154 ENOG4108YXU transcriptional regulator AsnC family BF33_1155 ENOG4105CHR reductase BF33_1156 ENOG4108IG5 Transcriptional regulator BF33_1157 ENOG4107P5I polyketide synthase BF33_1159 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF33_1160 ENOG4105BZU Histidine kinase BF33_1164 ENOG41085FC arsR family transcriptional regulator BF33_1165 ENOG4105D6J arsenicaL-resistance protein BF33_1172 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BF33_1173 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BF33_1175 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BF33_1176 ENOG4108TWJ NADH dehydrogenase subunit 5 BF33_1179 ENOG4105CVP deoxyribo-dipyrimidine photolyase BF33_1180 ENOG4108606 TspO/MBR family BF33_1187 ENOG41090MY MarR family Transcriptional regulator BF33_1192 ENOG4105CHJ isochorismatase hydrolase BF33_1194 ENOG4105CH6 catalase BF33_1195 ENOG4105CGH 5'-nucleotidase BF33_1198 ENOG4105CSV Glutaminase BF33_1202 ENOG4108Q8B Spore germination protein BF33_1203 ENOG4108NHD germination protein BF33_1206 ENOG4105II7 pyrroline-5-carboxylate reductase BF33_1208 ENOG4105CUB amino acid BF33_1209 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BF33_1211 ENOG4108IMY Transcriptional regulator BF33_1212 ENOG4105HDK L-asparaginase BF33_1213 ENOG4108IJ0 Aspartate ammonia-lyase BF33_1215 ENOG4105E2A Dehydrogenase BF33_1230 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BF33_1236 ENOG4105DWD nucleoside recognition domain protein BF33_1240 ENOG4105FDT acyl-CoA dehydrogenase BF33_1242 ENOG4108ZHR arsR family transcriptional regulator BF33_1243 ENOG4108ZRV stage ii sporulation protein p BF33_1244 ENOG4106N3A copper homeostasis protein cutc BF33_1246 ENOG4107258 Transcriptional regulator BF33_1247 ENOG4105P4J Allophanate hydrolase, subunit 1 BF33_1254 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BF33_1256 ENOG4107RF6 penicillin-binding protein BF33_1262 ENOG4105F1N DNA alkylation repair BF33_1264 ENOG4108IQI permease BF33_1265 ENOG4105KNA -acetyltransferase BF33_1266 ENOG410635A Membrane BF33_1279 ENOG4108XET gCN5-related N-acetyltransferase BF33_1285 ENOG4105C19 ABC transporter BF33_1287 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF33_1293 ENOG4105EFZ amidohydrolase BF33_1294 ENOG4105D2S major facilitator superfamily BF33_1295 ENOG4105G9B Transcriptional regulator BF33_1297 ENOG4105VZJ PTS System BF33_13 ENOG410812S Rna-binding protein BF33_1300 ENOG4108QVC Component IIC BF33_1301 ENOG4105VCP PTS System BF33_1302 ENOG4105CS2 ec 3.2.1.21 BF33_1303 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BF33_1304 ENOG4105E39 Enoyl-CoA hydratase BF33_1305 ENOG4105CHU acetyl-coa acetyltransferase BF33_1306 ENOG4105CEY Amp-dependent synthetase and ligase BF33_1310 ENOG4105ERH Fumarylacetoacetate hydrolase BF33_1314 ENOG4105FS7 Transcriptional regulator BF33_1315 ENOG4108TVJ Nitroreductase BF33_1324 ENOG4105C8Y Acetylornithine aminotransferase BF33_1326 ENOG4105CKK Glycosyl transferase, family 2 BF33_1335 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF33_1341 ENOG41068WN BF33_1343 ENOG4108WCX response regulator BF33_1345 ENOG41090T1 Membrane BF33_1348 ENOG4105VMP Transcriptional regulator BF33_1350 ENOG4105G6Z alkaline phosphatase BF33_1351 ENOG4105ECK Fatty Acid Desaturase BF33_1352 ENOG4105E0Y RtcB Protein BF33_1354 ENOG4107258 Transcriptional regulator BF33_1360 ENOG4105II7 pyrroline-5-carboxylate reductase BF33_1361 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BF33_1367 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BF33_1372 ENOG41061GT Aldolase BF33_1374 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) BF33_1375 ENOG4105DKT Transcriptional regulator BF33_1377 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane BF33_1379 ENOG4105D4B ABC, transporter BF33_138 ENOG4105C0D helicase BF33_1383 ENOG4108JUB Transcriptional regulator BF33_1384 ENOG4105J5T Amp-dependent synthetase and ligase BF33_1385 ENOG4105E39 Enoyl-CoA hydratase BF33_1386 ENOG4105CY2 Citrate transporter BF33_1388 ENOG41069ER domain protein BF33_1395 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BF33_1397 ENOG4105CIH Imidazole acetol-phosphate transaminase BF33_1401 ENOG41082JN Transcriptional regulator BF33_1402 ENOG4105EYF MMPL domain protein BF33_1404 ENOG4105C5H ABC transporter BF33_1405 ENOG4105E0M Sulfatase BF33_1406 ENOG4108ZCF integral membrane protein BF33_1408 ENOG4107VMI polysaccharide deacetylase BF33_1410 ENOG4107VC0 DNA alkylation repair enzyme BF33_1420 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BF33_1424 ENOG4105E09 nadh pyrophosphatase BF33_1429 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BF33_1430 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BF33_1431 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BF33_1433 ENOG4105C02 permease BF33_144 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF33_1442 ENOG4105DVE abc transporter atp-binding protein BF33_1445 ENOG4108ZMI UPF0477 protein BF33_1448 ENOG4105CHM Aminotransferase BF33_145 ENOG4105CJ1 ABC, transporter BF33_1455 ENOG41089UC methyltransferase, type 11 BF33_1458 ENOG4107BMA Transglycosylase associated protein BF33_1462 ENOG4106K7D Major facilitator family transporter BF33_1463 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BF33_1471 ENOG4105EPR degv family BF33_1473 ENOG4105DPN Oligoendopeptidase f BF33_1480 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF33_1481 ENOG4105BZU Histidine kinase BF33_1482 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BF33_1489 ENOG4105DTQ mandelate racemase muconate lactonizing BF33_1492 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BF33_1493 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BF33_1496 ENOG4107T5V SNARE associated Golgi BF33_15 ENOG4108WF2 Metal Dependent Phosphohydrolase BF33_1502 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein BF33_1504 ENOG41080HI glycine oxidase BF33_1505 ENOG4105CTU Proline racemase BF33_1506 ENOG4105CTU Proline racemase BF33_1507 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BF33_1508 ENOG4105C26 Dehydrogenase BF33_1509 ENOG4105BZG amino acid carrier protein BF33_1512 ENOG4108M1A Chitin-binding protein BF33_152 ENOG41080TC multidrug resistance protein BF33_1521 ENOG4105C9U ATP-dependent DNA helicase RecQ BF33_1525 ENOG4105EEM helicase BF33_1529 ENOG4108Z7F N-acetyltransferase BF33_1536 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BF33_1540 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF33_1544 ENOG41087PP glycosyltransferase MGT family BF33_1545 ENOG4108M1A Chitin-binding protein BF33_1546 ENOG41082BV acetyltransferase BF33_1547 ENOG4105E66 phosphoriboisomerase A BF33_1552 ENOG4108IJ7 Glycine betaine BF33_1553 ENOG4107SQ8 Glycine betaine BF33_156 ENOG4105WZW rhodanese family BF33_1561 ENOG4105RHY Pfam:UPF0157 BF33_1562 ENOG4105E1F short-chain dehydrogenase reductase BF33_1564 ENOG4107RUY (E1 component), alpha subunit BF33_1566 ENOG4107QKR Dehydrogenase BF33_157 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BF33_1571 ENOG4105E98 transcriptional regulator DeoR family BF33_1575 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BF33_1579 ENOG4107Z3H Transcriptional regulator, TetR family BF33_1586 ENOG4105MSI germination protein ypeb BF33_1597 ENOG4105FDR Membrane BF33_1599 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BF33_1604 ENOG4108IUM Glycogen debranching enzyme BF33_1607 ENOG4105DY8 decarboxylase BF33_1612 ENOG4105U0R haloacid dehalogenase-like hydrolase BF33_1617 ENOG4107VFR oxidoreductase BF33_162 ENOG4107YBY Hydrolase BF33_1625 ENOG4105PKS Excinuclease abc c subunit domain protein BF33_163 ENOG4105CBJ Metal-dependent enzyme BF33_1632 ENOG4105KWG Pfam:DUF1696 BF33_1633 ENOG4108NRW Phospholipase, patatin family BF33_1637 ENOG4108XI2 Domain of unknown function (DUF1963) BF33_1645 ENOG4108Z4K mutator MutT protein BF33_1646 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BF33_1647 ENOG4105E09 nadh pyrophosphatase BF33_1650 ENOG4105FCD Major Facilitator BF33_1658 ENOG4107Y9U Membrane BF33_166 ENOG4105DC7 peptidase M24 BF33_1662 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BF33_1666 ENOG4107Y80 Major Facilitator superfamily BF33_1671 ENOG4108V4B ThiJ pfpI BF33_1677 ENOG4105FQP Beta-lactamase BF33_1679 ENOG4105CJN penicillin-binding protein BF33_1680 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BF33_1681 ENOG4105CB2 alcohol dehydrogenase BF33_1684 ENOG4108HGU Histidine kinase BF33_1691 ENOG4107RF6 penicillin-binding protein BF33_1692 ENOG4105BZU Histidine kinase BF33_1693 ENOG410667J hydrolase BF33_17 ENOG4105DXX methyltransferase BF33_1709 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF33_171 ENOG4105CD2 stage iii sporulation protein aa BF33_172 ENOG4105KR5 Stage iii sporulation protein BF33_173 ENOG4108CQH stage III sporulation protein AC BF33_174 ENOG4105KQ4 Stage iii sporulation protein ad BF33_1741 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein BF33_176 ENOG410644B Stage III sporulation protein af BF33_1761 ENOG4105VTR Integrase BF33_1769 ENOG4105ETU transcriptional activator (TenA BF33_1786 ENOG4105DK7 lysyl-tRNA synthetase BF33_1788 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein BF33_1792 ENOG4105CPQ Dehydrogenase BF33_1799 ENOG4105CUV Homoserine Kinase BF33_1803 ENOG4107Y80 Major Facilitator superfamily BF33_1805 ENOG4105FQP Beta-lactamase BF33_181 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BF33_1815 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BF33_1817 ENOG4105T9C HD domain BF33_182 ENOG4108ZSR alkaline shock protein BF33_1820 ENOG4105DZ1 carboxypeptidase BF33_1823 ENOG4105DBI uridine monophosphokinase BF33_1824 ENOG4105WCN acetyltransferase BF33_1826 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BF33_1827 ENOG4107QX3 carboxylase BF33_1828 ENOG4105E39 Enoyl-CoA hydratase BF33_1829 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BF33_1830 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BF33_1831 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BF33_1832 ENOG4105C1G acyl-Coa dehydrogenase BF33_1835 ENOG4107Z3H Transcriptional regulator, TetR family BF33_1837 ENOG4105CJ1 ABC, transporter BF33_1840 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) BF33_1843 ENOG4105BZU Histidine kinase BF33_1844 ENOG4105C5H ABC transporter BF33_1845 ENOG41067SE Tetr family transcriptional regulator BF33_1846 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity BF33_1849 ENOG4108VXD carboxy-peptidase BF33_1852 ENOG4105VZ8 Transcriptional regulator BF33_1855 ENOG4105CGH 5'-nucleotidase BF33_1858 ENOG4105DH8 myo-inositol catabolism BF33_1859 ENOG4105D2N Aldolase BF33_1864 ENOG4105CK5 oxidoreductase BF33_1865 ENOG4105IE8 Alpha-ketoglutarate permease BF33_1866 ENOG4105ETE Transcriptional regulator (LacI family BF33_1867 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BF33_1869 ENOG4107RF6 penicillin-binding protein BF33_187 ENOG4105CTB Polyprenyl synthetase BF33_1870 ENOG4107RF6 penicillin-binding protein BF33_1875 ENOG4105CIN aminoacyl-histidine dipeptidase BF33_1882 ENOG41090HR transcriptional regulator BF33_1883 ENOG4107RA9 decarboxylase BF33_1884 ENOG4108I0C methyltransferase BF33_1886 ENOG41088CC tellurite resistance protein tehB BF33_189 ENOG4105DX0 Hemolysin A BF33_1890 ENOG4108RZE Tetr family transcriptional regulator BF33_1893 ENOG4105C1J atp-dependent rna helicase BF33_1896 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BF33_19 ENOG4105KQC Competence protein BF33_1901 ENOG4107STF Involved in phosphonate degradation (By similarity) BF33_1903 ENOG4105RD7 BadF BadG BcrA BcrD BF33_1908 ENOG4105F32 YngK protein BF33_191 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BF33_1913 ENOG4108KPJ rna polymerase sigma factor BF33_1916 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BF33_192 ENOG4105S1Z Stage IV sporulation protein B BF33_1923 ENOG4108JCI Transcriptional regulator BF33_1927 ENOG4105BZ1 (ABC) transporter BF33_1928 ENOG4105BZ1 (ABC) transporter BF33_193 ENOG4107QQR Sporulation BF33_1931 ENOG4108RPX mosc domain containing protein BF33_1932 ENOG4105DND Transcriptional regulator BF33_1935 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BF33_1936 ENOG4107V2S Transcriptional regulator BF33_1943 ENOG410667J hydrolase BF33_1947 ENOG4105VEQ Cold shock protein BF33_1949 ENOG41068WN BF33_1951 ENOG4105C1Q protoporphyrinogen oxidase BF33_1957 ENOG4105WCN acetyltransferase BF33_196 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BF33_1962 ENOG4105EYF MMPL domain protein BF33_1964 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BF33_1967 ENOG41081I9 integral membrane protein BF33_1971 ENOG4108D32 Methyltransferase BF33_1975 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BF33_1977 ENOG4105C19 ABC transporter BF33_1978 ENOG4105C22 threonyL-tRNA synthetase BF33_1979 ENOG4105FE9 pseudouridine synthase BF33_198 ENOG4108JUB Transcriptional regulator BF33_1983 ENOG4105BZG amino acid carrier protein BF33_1987 ENOG4105K70 DNA-binding protein BF33_1990 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF33_1991 ENOG4105WQT MbtH domain protein BF33_1992 ENOG4105CEY Amp-dependent synthetase and ligase BF33_1993 ENOG4105WQI isochorismatase BF33_1994 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BF33_1995 ENOG4105E4F Isochorismate synthase BF33_1996 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BF33_1997 ENOG4105FCD Major Facilitator BF33_20 ENOG4108UK2 deaminase BF33_200 ENOG4107RDP Dehydrogenase BF33_2001 ENOG4105EYH Exonuclease BF33_2002 ENOG4107RFY SbcCD D subunit BF33_2005 ENOG4105E39 Enoyl-CoA hydratase BF33_2006 ENOG4105N14 lysine exporter protein LysE YggA BF33_2008 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF33_2009 ENOG4105C1G acyl-Coa dehydrogenase BF33_2010 ENOG4105CR4 methylisocitrate lyase BF33_2011 ENOG4105DXD 2-methylcitrate dehydratase BF33_2013 ENOG4105W8X HesB YadR YfhF-family protein BF33_2014 ENOG4105DP8 Major facilitator superfamily MFS_1 BF33_2015 ENOG4105BZ4 penicillin-binding protein BF33_2023 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF33_204 ENOG4105CPP Dehydrogenase, E1 component BF33_2043 ENOG4108IBT Inherit from COG: transposase BF33_2045 ENOG4105SZ6 Thioredoxin BF33_2046 ENOG410841Q phosphoesterase PA-phosphatase related protein BF33_2048 ENOG4108N23 SpoOM-related protein BF33_205 ENOG4105C7S Dehydrogenase BF33_2056 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BF33_2057 ENOG4108JUB Transcriptional regulator BF33_2058 ENOG4108TSC N-acetyltransferase BF33_2059 ENOG4107S4Y M20 DapE family protein YgeY BF33_2062 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF33_2067 ENOG4105C37 (CBS) domain BF33_207 ENOG4105E09 nadh pyrophosphatase BF33_2074 ENOG4105E90 ABC transporter BF33_2075 ENOG4108IJ8 ABC transporter BF33_208 ENOG4105G7B Protein of unknown function (DUF2992) BF33_2081 ENOG4105CMG Carbohydrate kinase BF33_2082 ENOG4105CMG Carbohydrate kinase BF33_2088 ENOG4106KNT transcriptional regulator BF33_2090 ENOG4105WH1 Two component transcriptional regulator luxr family BF33_2091 ENOG4105BZU Histidine kinase BF33_2092 ENOG4105D8X mechanosensitive ion channel BF33_2093 ENOG4107Y70 Heat shock protein BF33_2099 ENOG4105F0I Aminotransferase BF33_21 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BF33_210 ENOG4108HW3 (ABC) transporter BF33_2100 ENOG4108MES Periplasmic binding protein BF33_2104 ENOG4105CAQ asparagine synthetase BF33_2105 ENOG4107Y70 Heat shock protein BF33_2106 ENOG4108KF3 Electron transport protein SCO1 SenC BF33_2107 ENOG4105E8R UPF0173 metal-dependent hydrolase BF33_2108 ENOG4108RCR degv family BF33_211 ENOG4105E5Q amino acid AbC transporter BF33_2110 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BF33_2112 ENOG4108UT2 hemolysin iii BF33_2113 ENOG4105E9Q Acyl-transferase BF33_2115 ENOG4107RVG penicillin-binding protein BF33_2118 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) BF33_212 ENOG4105CDA abc transporter atp-binding protein BF33_2121 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 BF33_2126 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BF33_2127 ENOG4105KD7 acetyltransferase BF33_213 ENOG4108QEG Membrane BF33_2131 ENOG4105CY2 Citrate transporter BF33_2132 ENOG4107XGZ Hydrolase BF33_2136 ENOG4105C8J )-transporter BF33_2139 ENOG41062D9 Histidine kinase BF33_214 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BF33_2140 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF33_2141 ENOG4107QPK )-transporter BF33_2142 ENOG4105BZW Glycerate kinase BF33_2153 ENOG4105EC2 ftsk spoIIIe BF33_2157 ENOG4105C5S asparaginyl-tRNA synthetase BF33_2158 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BF33_216 ENOG4105D9U N-acetyltransferase BF33_2161 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BF33_2165 ENOG4105C75 arginyL-tRNA synthetase BF33_2166 ENOG4105EKQ RNA-directed DNA polymerase BF33_217 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BF33_2171 ENOG4105EKQ RNA-directed DNA polymerase BF33_2172 ENOG4108UUM single-stranded DNA-binding protein BF33_2175 ENOG4105C5H ABC transporter BF33_2180 ENOG4105MCT stage V sporulation protein S BF33_2187 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BF33_2188 ENOG4108IFG nitrite reductase, (NAD(P)H) BF33_2189 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BF33_219 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF33_2190 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BF33_2191 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BF33_2192 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BF33_2196 ENOG4108ZAF Molybdopterin BF33_2197 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF33_2198 ENOG4105D06 uba thif-type nad fad binding protein BF33_2199 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BF33_2200 ENOG4107V6Q Cyclic nucleotide-binding domain BF33_2203 ENOG4105D3W isochorismatase BF33_2204 ENOG4108X3M OsmC Ohr family protein BF33_2205 ENOG4106HZJ BF33_2206 ENOG4107QN2 dihydrolipoyl dehydrogenase BF33_2207 ENOG4105K63 Thioredoxin BF33_2208 ENOG4108Z40 Transcriptional regulator BF33_2211 ENOG4105R3A Nitrate reductase BF33_2212 ENOG4108IUE nitrate reductase beta subunit BF33_2214 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF33_2217 ENOG4108V06 Glutathione peroxidase BF33_2221 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) BF33_2223 ENOG4105EMN RNA polymerase sigma factor BF33_2224 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BF33_2226 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BF33_2227 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BF33_223 ENOG4105EJQ L-serine dehydratase BF33_2231 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BF33_2236 ENOG4105KBJ sporulation protein ytfj BF33_2238 ENOG4105EKQ RNA-directed DNA polymerase BF33_224 ENOG4105II7 pyrroline-5-carboxylate reductase BF33_225 ENOG41069FQ Metallo-beta-lactamase superfamily BF33_2250 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BF33_2256 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF33_2257 ENOG4108JYZ YitT family BF33_2258 ENOG41087PP glycosyltransferase MGT family BF33_226 ENOG4108IXY short-chain dehydrogenase reductase BF33_2261 ENOG4107RBS Methyltransferase BF33_2262 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BF33_2264 ENOG4108X4Q Hydrolase BF33_2269 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BF33_2271 ENOG4108VXD carboxy-peptidase BF33_2273 ENOG4108ZRV stage ii sporulation protein p BF33_2277 ENOG4108Z7R Chaperone CsaA BF33_2281 ENOG4105C37 (CBS) domain BF33_2282 ENOG4105SXS Protein of unknown function (DUF456) BF33_2286 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF33_2287 ENOG4108S4H thioesterase Superfamily protein BF33_2289 ENOG4108PJD permease BF33_229 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BF33_2292 ENOG4107T5V SNARE associated Golgi BF33_2296 ENOG4107TB6 phosphoglycerate mutase BF33_23 ENOG4105TQK DNA polymerase iii, delta' subunit BF33_2301 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BF33_2303 ENOG4105K4T epimerase BF33_2305 ENOG4105DSE periplasmic solute binding protein BF33_2317 ENOG4105CKI cobalamin synthesis protein BF33_2318 ENOG4107QM2 Aldo Keto reductase BF33_2322 ENOG4105DEN Luciferase family BF33_2325 ENOG4108WPJ Ferritin-like domain BF33_2326 ENOG4108K88 Membrane BF33_2329 ENOG4105C8Q Methyl-accepting chemotaxis BF33_2334 ENOG4107XZQ multidrug resistance protein BF33_2335 ENOG4107SET aldo keto reductase BF33_2336 ENOG4105YVS arsR family transcriptional regulator BF33_2338 ENOG4105KRN Transcriptional regulator, abrb family BF33_2348 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BF33_2350 ENOG4105YWU small acid-soluble spore protein BF33_2351 ENOG4108WBH protein TIM barrel BF33_2354 ENOG4105CEY Amp-dependent synthetase and ligase BF33_2355 ENOG4105DUU IucA IucC family protein BF33_2357 ENOG4105VRR gCN5-related N-acetyltransferase BF33_2358 ENOG4105KT7 mgtC SapB transporter BF33_2360 ENOG4107VMI polysaccharide deacetylase BF33_2361 ENOG4105BZU Histidine kinase BF33_2362 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF33_2364 ENOG4108KGH TRANSCRIPTIONal BF33_2369 ENOG4105D6E homoserine dehydrogenase BF33_237 ENOG4105CGH 5'-nucleotidase BF33_2372 ENOG4106AKJ BF33_2373 ENOG4108ZJ4 polysaccharide deacetylase BF33_2374 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BF33_2377 ENOG4105BZU Histidine kinase BF33_2378 ENOG4105EFI regulatoR BF33_2379 ENOG4105BZ1 (ABC) transporter BF33_238 ENOG4105DFD Na H antiporter BF33_2387 ENOG4108JJ8 (ABC) transporter BF33_2388 ENOG4108JJ9 ABC, transporter BF33_2389 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BF33_2390 ENOG4105C4M (Ubiquinol oxidase) subunit I BF33_2394 ENOG4105MDS 4-oxalocrotonate tautomerase BF33_2396 ENOG4105SKE transcriptional Regulator LysR family BF33_2398 ENOG4105C32 Amino acid ABC transporter (Permease) BF33_2399 ENOG4108IV0 ABC, transporter BF33_240 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF33_2400 ENOG4105C0Z ABC transporter BF33_2402 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF33_2403 ENOG4108Z7G MaoC domain protein dehydratase BF33_2407 ENOG4105CKI cobalamin synthesis protein BF33_2409 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF33_2410 ENOG4106F5Q Membrane BF33_2411 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BF33_2414 ENOG4108TVJ Nitroreductase BF33_2415 ENOG4107ZXU DSBA oxidoreductase BF33_2416 ENOG4108Z40 Transcriptional regulator BF33_2417 ENOG4105GZI Transcriptional regulator BF33_2418 ENOG4107RT3 EamA-like transporter family BF33_2419 ENOG4105KTB nuclear export factor GLE1 BF33_242 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BF33_2420 ENOG4108T5E Copper resistance protein BF33_2429 ENOG4107R16 Multicopper oxidase BF33_243 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF33_2430 ENOG4107RAQ aminopeptidase BF33_2436 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BF33_2437 ENOG4105D9N nucleoside BF33_2439 ENOG4107RHR regulatoR BF33_244 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF33_2444 ENOG4105C0X amino acid BF33_2446 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BF33_2448 ENOG4105C72 UPF0176 protein BF33_2449 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BF33_245 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BF33_2453 ENOG41068WN BF33_2462 ENOG4105CYC Transferase BF33_2463 ENOG4105DY9 regulatoR BF33_2465 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BF33_2466 ENOG4105C6X Major Facilitator BF33_2471 ENOG4105C7B Threonine dehydratase BF33_2473 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BF33_2474 ENOG4108ZP8 Acetolactate synthase small subunit BF33_2475 ENOG4105C7K acetolactate synthase BF33_2476 ENOG4105CM2 brancheD-chain amino acid aminotransferase BF33_2477 ENOG4105CHR reductase BF33_2478 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BF33_2482 ENOG4105H67 Protein of unknown function (DUF421) BF33_2483 ENOG4105X5K response regulator receiver protein BF33_2485 ENOG4105C8J )-transporter BF33_2489 ENOG4105C6T cysteine synthase BF33_249 ENOG4108R6K riboflavin synthase, subunit alpha BF33_2490 ENOG4105EU0 Major facilitator Superfamily BF33_2492 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BF33_2495 ENOG4105DXI Major Facilitator superfamily BF33_2496 ENOG4105CSR polyphosphate kinase 2 BF33_250 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BF33_2504 ENOG4105FVX BF33_2516 ENOG4105C6K Malic enzyme BF33_2517 ENOG4108IJ0 Aspartate ammonia-lyase BF33_2519 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BF33_2523 ENOG4105CJ1 ABC, transporter BF33_2530 ENOG4106BRA Membrane BF33_2536 ENOG4107QIV Cytochrome c biogenesis protein BF33_254 ENOG4108YM7 Gcn5-related n-acetyltransferase BF33_2540 ENOG4105EC3 peptidase S51, dipeptidase E BF33_2541 ENOG4107QJQ Mate efflux family protein BF33_2545 ENOG4105C9Q fumarate hydratase class II BF33_2547 ENOG4105VUF Transcriptional regulator BF33_2548 ENOG4105DFD Na H antiporter BF33_255 ENOG4105ETE Transcriptional regulator (LacI family BF33_2551 ENOG4108PJD permease BF33_2552 ENOG4105CKI cobalamin synthesis protein BF33_2553 ENOG4108UZ3 Transporter BF33_2554 ENOG4105DRR Transcriptional regulator, GntR family BF33_2556 ENOG4105PGM cation diffusion facilitator family transporter BF33_2560 ENOG4105CAQ asparagine synthetase BF33_2562 ENOG4105K56 Transcriptional regulator BF33_2566 ENOG4105CVJ phosphoglycerate mutase BF33_257 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BF33_2573 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BF33_2574 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component BF33_2576 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF33_2577 ENOG4105DUM transcriptional regulator, lysR family BF33_2582 ENOG4105KAC Antibiotic biosynthesis monooxygenase BF33_2589 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF33_2590 ENOG4105KTQ flagellar basal-body rod protein BF33_2591 ENOG4105FZW flagellar biosynthesis regulator FlhF BF33_2592 ENOG4105D7B Flagellar biosynthesis protein flha BF33_2593 ENOG4105D00 flagellar biosynthetic protein flhB BF33_2595 ENOG4105VS8 Flagellar biosynthetic protein fliq BF33_2596 ENOG4105CN7 Flagellar biosynthetic protein FliP BF33_2598 ENOG4105DD5 Flagellar motor switch protein BF33_2599 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BF33_2601 ENOG4105E4C Lytic transglycosylase catalytic BF33_2602 ENOG4105I03 Flagellin BF33_2603 ENOG4105I03 Flagellin BF33_2605 ENOG4107R88 Chemotaxis protein (CheV) BF33_2608 ENOG4105BZE flagellar hook protein, FlgE BF33_261 ENOG4105RHY Pfam:UPF0157 BF33_2614 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BF33_2615 ENOG4107U2N Flagellar M-ring protein BF33_2616 ENOG41075Z6 flagellar hook-basal body complex protein fliE BF33_2617 ENOG4108ZC9 flagellar basal-body rod protein flgc BF33_2618 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BF33_2621 ENOG4107TPX flagellar hook-associated BF33_2622 ENOG4105DTJ flagellar hook-associated protein BF33_2623 ENOG4105E1Q flagellar hook-associated protein BF33_2627 ENOG4105BZU Histidine kinase BF33_263 ENOG4105CPC Aldo Keto reductase BF33_2630 ENOG4105DD5 Flagellar motor switch protein BF33_2631 ENOG4105CBS Chea signal transduction histidine kinase BF33_2632 ENOG4105CBS Chea signal transduction histidine kinase BF33_2633 ENOG4107YTP response regulator receiver protein BF33_2634 ENOG4105ER2 Ompa motb domain protein BF33_2635 ENOG4107R0U MotA TolQ exbB proton channel BF33_2637 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BF33_2648 ENOG41080C8 DUF218 domain BF33_2649 ENOG4105H67 Protein of unknown function (DUF421) BF33_2651 ENOG4108Z5V transcriptional regulator, merr family BF33_2652 ENOG4105CN5 Metallo-Beta-Lactamase BF33_2653 ENOG4107RWR Sodium hydrogen exchanger BF33_2655 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF33_2668 ENOG41081VK Ribonuclease BF33_267 ENOG4105MZ9 stage II sporulation protein m BF33_2672 ENOG4108SZE gCN5-related N-acetyltransferase BF33_2675 ENOG4105CPK Glycosyl transferase (Group 1 BF33_268 ENOG4105I3K Ferric uptake regulator, Fur family BF33_2687 ENOG4106032 Glutathionylspermidine synthase BF33_2690 ENOG4105KHC sulfurtransferase BF33_2692 ENOG4108W0I acetyltransferase BF33_2694 ENOG410890F Dynamin family BF33_2696 ENOG4105DHF Membrane BF33_2697 ENOG4105C2W permease BF33_2699 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BF33_270 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF33_2702 ENOG4105CTD carboxy-peptidase BF33_2703 ENOG4105DVT helicase BF33_2705 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BF33_2716 ENOG4105BZ4 penicillin-binding protein BF33_2718 ENOG4105CSM endonuclease III BF33_2722 ENOG4105YAC BF33_2723 ENOG4105DVT helicase BF33_2730 ENOG4105CPK Glycosyl transferase (Group 1 BF33_2731 ENOG4105FJR Lmbe family BF33_2734 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BF33_2735 ENOG4108JYZ YitT family BF33_2741 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit BF33_2742 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BF33_2743 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BF33_2746 ENOG41068YB TPR repeat-containing protein BF33_2747 ENOG4105CIH Imidazole acetol-phosphate transaminase BF33_275 ENOG4105D7N magnesium and cobalt transport protein CorA BF33_2751 ENOG4105EAH synthase BF33_2753 ENOG4105XXQ heptaprenyl diphosphate synthase component I BF33_2756 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BF33_2762 ENOG41065D1 BF33_2763 ENOG4105S2F BF33_2770 ENOG4107RB3 L-asparaginase BF33_2771 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BF33_2776 ENOG4108S6Z Negative regulator of genetic competence BF33_2777 ENOG4107X2D transcriptional regulator, merr family BF33_2778 ENOG4107RGJ metallophosphoesterase BF33_2780 ENOG4105I7S Abortive infection protein BF33_2781 ENOG4105C9U ATP-dependent DNA helicase RecQ BF33_2784 ENOG4108SAX Membrane BF33_2786 ENOG41063SB peptidase BF33_2787 ENOG4108WBT adenosyltransferase BF33_2788 ENOG4105BZU Histidine kinase BF33_2789 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF33_2790 ENOG4105CRE cytochrome C BF33_2791 ENOG4107TWT Cytochrome c biogenesis protein BF33_2793 ENOG4105FE9 pseudouridine synthase BF33_2795 ENOG4108JIC nucleoside recognition domain protein BF33_2796 ENOG4105DZ1 carboxypeptidase BF33_2797 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF33_28 ENOG4105KVH Transcriptional regulator BF33_2804 ENOG4105BZU Histidine kinase BF33_2807 ENOG4105I3N Conserved Protein BF33_2808 ENOG4105BZU Histidine kinase BF33_281 ENOG4105DVE abc transporter atp-binding protein BF33_2811 ENOG4105BZ4 penicillin-binding protein BF33_2812 ENOG4107GRR phosphate transport regulator BF33_2813 ENOG4105CJ3 phosphate transporter BF33_282 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF33_2822 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BF33_2826 ENOG4105WH1 Two component transcriptional regulator luxr family BF33_2827 ENOG4105ENE Histidine kinase BF33_283 ENOG4105DZ1 carboxypeptidase BF33_2831 ENOG4105DFD Na H antiporter BF33_2835 ENOG4105C8J )-transporter BF33_2836 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BF33_2837 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BF33_2838 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BF33_284 ENOG41082AN stage II sporulation protein BF33_2840 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BF33_2841 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BF33_2845 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BF33_2847 ENOG4105E0M Sulfatase BF33_2848 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BF33_2851 ENOG4107RVV histidinol phosphate phosphatase, hisj family BF33_286 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF33_2866 ENOG4108ZP8 Acetolactate synthase small subunit BF33_2867 ENOG4105C7K acetolactate synthase BF33_2868 ENOG4105CM2 brancheD-chain amino acid aminotransferase BF33_287 ENOG4105C8J )-transporter BF33_2872 ENOG4105KBJ sporulation protein ytfj BF33_2873 ENOG41063Y9 BF33_2874 ENOG4105CZN Potassium uptake protein BF33_2880 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF33_2881 ENOG4107QMU Mate efflux family protein BF33_2888 ENOG4105NQC Flavodoxin BF33_2893 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF33_2895 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BF33_2896 ENOG4105EA8 2-Nitropropane dioxygenase BF33_2897 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BF33_29 ENOG4105CSA Coproporphyrinogen iii oxidase BF33_2905 ENOG4105CJ1 ABC, transporter BF33_2907 ENOG4105CZV ABC transporter BF33_2908 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BF33_2909 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF33_291 ENOG41090VF Stage v sporulation protein ac BF33_2910 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF33_2912 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF33_2913 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BF33_292 ENOG4105CZ3 stage V sporulation protein ad BF33_2921 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BF33_2922 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BF33_2924 ENOG4105BZU Histidine kinase BF33_2926 ENOG4106DF1 BF33_2928 ENOG41090MY MarR family Transcriptional regulator BF33_2929 ENOG4105BZU Histidine kinase BF33_2931 ENOG4105PXI polysaccharide deacetylase BF33_2933 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BF33_2936 ENOG4105E98 transcriptional regulator DeoR family BF33_2939 ENOG4108KAZ Involved in phosphonate degradation (By similarity) BF33_294 ENOG4105G6R Stage v sporulation protein ae BF33_2940 ENOG4107RCV ABC transporter, permease BF33_2941 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF33_2942 ENOG4105C4Y ABC transporter BF33_2946 ENOG4105MWK D-amino acid dehydrogenase, small subunit BF33_2948 ENOG4105CHR reductase BF33_2952 ENOG4108Z7G MaoC domain protein dehydratase BF33_2953 ENOG410681C small acid-soluble spore protein BF33_2954 ENOG4105CZN Potassium uptake protein BF33_2955 ENOG4107TS3 membrane protein, TerC BF33_2956 ENOG4108QTI )-transporter BF33_2958 ENOG4106A3R peptidase BF33_296 ENOG4105J7I hydrolase BF33_2962 ENOG4105JXH GntR family transcriptional regulator BF33_2963 ENOG4105BZU Histidine kinase BF33_2964 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF33_2967 ENOG4105CQB FAD linked oxidase domain protein BF33_2968 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BF33_2969 ENOG4105K4I Scp-like extracellular BF33_297 ENOG4105PTM secreted protein BF33_2971 ENOG4108YBP pseudouridine synthase BF33_2973 ENOG4105EYF MMPL domain protein BF33_2975 ENOG4107RUE extracellular solute-binding protein family 1 BF33_2976 ENOG4105D38 putrescine abc transporter BF33_2977 ENOG4105F38 ABC transporter, permease BF33_2979 ENOG4105C26 Dehydrogenase BF33_298 ENOG4107ZE5 PPIases accelerate the folding of proteins BF33_2985 ENOG4105VFR signal peptidase BF33_2986 ENOG4105DZ1 carboxypeptidase BF33_2988 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BF33_2991 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF33_2995 ENOG4105EFC phage portal protein HK97 family BF33_3 ENOG4108TVJ Nitroreductase BF33_3002 ENOG4108NE4 BF33_3022 ENOG4105VZ8 Transcriptional regulator BF33_3024 ENOG4105C7S Dehydrogenase BF33_3044 ENOG4105DDQ anthranilate synthase BF33_3045 ENOG4105CRQ synthase (Component I) BF33_3046 ENOG4105CK7 Sodium proline symporter BF33_305 ENOG4105CE4 GlcNAc 6-P deacetylase BF33_3060 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BF33_3062 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BF33_3063 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BF33_3067 ENOG4107TVC Glycosyl transferase, family 2 BF33_307 ENOG4105FDP GntR family transcriptional regulator BF33_3071 ENOG4105K64 Glycosyl transferase, family 2 BF33_3075 ENOG4105EMS pseudouridine synthase BF33_3076 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BF33_3079 ENOG4105MIX Adenylate cyclase BF33_3080 ENOG4108Z18 K06886 hemoglobin BF33_3083 ENOG4105DPN Oligoendopeptidase f BF33_3085 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF33_3087 ENOG4108ZCF integral membrane protein BF33_309 ENOG4105CID antiterminator BF33_3091 ENOG4105UQX Mate efflux family protein BF33_3092 ENOG4108JQ7 (ABC) transporter BF33_3094 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF33_3095 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF33_3098 ENOG4105C31 Tryptophanyl-tRNA synthetase BF33_31 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BF33_3101 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BF33_3102 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF33_3107 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BF33_3109 ENOG4108KP7 hydrolase BF33_3111 ENOG41073B9 BF33_3112 ENOG4107AYK membrAne BF33_3114 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF33_3116 ENOG4105QNR S1 RNA binding domain protein BF33_312 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BF33_3120 ENOG4105BZU Histidine kinase BF33_3121 ENOG4105CH6 catalase BF33_3122 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BF33_3123 ENOG4105CAQ asparagine synthetase BF33_3128 ENOG4105ERH Fumarylacetoacetate hydrolase BF33_3142 ENOG4105XVF Competence transcription factor BF33_3146 ENOG4105VEQ Cold shock protein BF33_3149 ENOG4107QP3 malate synthase g BF33_3150 ENOG4105ZU5 s-layer protein BF33_3154 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BF33_3159 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF33_316 ENOG4106TD9 Diguanylate cyclase BF33_3163 ENOG41086D8 Transcriptional regulator BF33_3164 ENOG4108AEY RNA polymerase sigma factor BF33_3166 ENOG4107TVP HD domain protein BF33_3168 ENOG4107RN3 metallophosphoesterase BF33_3169 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) BF33_317 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF33_3176 ENOG4105CNA YD repeat protein BF33_3179 ENOG4105CNA YD repeat protein BF33_3188 ENOG4105CEY Amp-dependent synthetase and ligase BF33_3190 ENOG4105DF9 Lipoate-protein, ligase BF33_3191 ENOG4108RQ5 Beta-lactamase domain-containing protein BF33_3192 ENOG4106AXD BF33_3194 ENOG4105D29 Helix-turn-helix type 11 domain protein BF33_3196 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) BF33_3200 ENOG4105ECB domain protein BF33_3207 ENOG4105C1Q protoporphyrinogen oxidase BF33_3210 ENOG4105BZ4 penicillin-binding protein BF33_3211 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BF33_3212 ENOG4105CKV Membrane BF33_3213 ENOG410905X membrane-flanked domain protein BF33_3221 ENOG4105CKV Membrane BF33_3222 ENOG410905X membrane-flanked domain protein BF33_3237 ENOG4105K59 histidine triad (HIT) protein BF33_3242 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF33_3243 ENOG4105EEM helicase BF33_3245 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF33_3246 ENOG4105C57 major facilitator superfamily BF33_3249 ENOG4105CNI cell division protein FtsW BF33_325 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BF33_3251 ENOG4105EMN RNA polymerase sigma factor BF33_3253 ENOG4105DQ6 Transposase BF33_3254 ENOG4105IYK transposase BF33_3255 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BF33_3258 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BF33_3262 ENOG4108MUZ hydrolase BF33_3273 ENOG4106D4I domain protein BF33_3274 ENOG4107VRP DNA repair exonuclease BF33_3283 ENOG4105K8R UPF0145 protein BF33_3288 ENOG4105BZU Histidine kinase BF33_3289 ENOG4105BZU Histidine kinase BF33_329 ENOG4105DTD Dehydrogenase BF33_3290 ENOG4108MJI response regulator BF33_3292 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF33_3294 ENOG4105WN5 stage II sporulation protein BF33_3307 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BF33_3309 ENOG4105CMT Dihydroxyacetone kinase BF33_3311 ENOG4105CMT Dihydroxyacetone kinase BF33_3317 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BF33_3333 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF33_3337 ENOG4105CDU Replicative dna helicase BF33_3348 ENOG4105M6F mutator MutT protein BF33_3350 ENOG4108MRH transcriptional regulatory protein BF33_3352 ENOG4105CSH Transporter BF33_3355 ENOG4108JQ7 (ABC) transporter BF33_3357 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF33_3365 ENOG4105CTU Proline racemase BF33_3369 ENOG4105DER m42 family BF33_337 ENOG4105CHU acetyl-coa acetyltransferase BF33_3373 ENOG4105CGU Enoyl-CoA hydratase BF33_3376 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF33_3377 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF33_3387 ENOG4105CHH sulfate transporter BF33_3390 ENOG4105D4P Coproporphyrinogen iii oxidase BF33_3391 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF33_3395 ENOG4107FQX Alpha-acetolactate decarboxylase BF33_3402 ENOG410839P BF33_3405 ENOG4105CDA abc transporter atp-binding protein BF33_3406 ENOG4105DRP amino acid AbC transporter BF33_3408 ENOG4105BZ1 (ABC) transporter BF33_3409 ENOG4105BZ1 (ABC) transporter BF33_3410 ENOG4105C26 Dehydrogenase BF33_3412 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BF33_3413 ENOG4105D5Q Arginine ornithine antiporter BF33_3415 ENOG4105CH6 catalase BF33_3416 ENOG4107RKG DJ-1/PfpI family BF33_3418 ENOG4105E5W Transporter BF33_3419 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BF33_3421 ENOG4105NF4 modulator of drug activity BF33_3426 ENOG4105KPY Small multidrug resistance protein BF33_3427 ENOG4105KPY Small multidrug resistance protein BF33_3429 ENOG4108YXU transcriptional regulator AsnC family BF33_3437 ENOG4106KNT transcriptional regulator BF33_3439 ENOG4107RWR Sodium hydrogen exchanger BF33_3440 ENOG4105CUB amino acid BF33_3447 ENOG4107T5V SNARE associated Golgi BF33_3454 ENOG4105WEF catalase BF33_346 ENOG4105CG3 alpha amylase, catalytic region BF33_3460 ENOG4105C19 ABC transporter BF33_3461 ENOG4107RBB ABC transporter, permease BF33_3462 ENOG41069ER domain protein BF33_3466 ENOG4105VZJ PTS System BF33_3467 ENOG4105VCP PTS System BF33_3468 ENOG4105EMD TRANSCRIPTIONal BF33_3473 ENOG4108KGH TRANSCRIPTIONal BF33_3475 ENOG41087NI Sulfite exporter TauE/SafE BF33_3476 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BF33_3478 ENOG41085GJ domain protein BF33_3479 ENOG4105VFE sira family BF33_348 ENOG4107FKK extracellular solute-binding protein family 1 BF33_3480 ENOG4107TPS domain protein BF33_3481 ENOG4105VFE sira family BF33_3482 ENOG4105XTG Pfam:DUF156 BF33_3483 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BF33_3485 ENOG4108TCS Glutamyl endopeptidase BF33_3487 ENOG4105ED1 spovr family BF33_3488 ENOG4107Y03 Nitroreductase BF33_3492 ENOG4108B31 Spore germination protein BF33_3499 ENOG4108PXI ErfK YbiS YcfS YnhG BF33_35 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BF33_350 ENOG4105EG2 ABC transporter, permease BF33_3501 ENOG4105C7N Xanthine uracil vitamin C permease BF33_3504 ENOG4108INS Transcriptional regulator BF33_351 ENOG4105FKQ transcriptional regulator BF33_3513 ENOG4105DWF phosphomethylpyrimidine kinase BF33_3514 ENOG4105D06 uba thif-type nad fad binding protein BF33_3517 ENOG41080HI glycine oxidase BF33_3518 ENOG4108VEU Thiamine monophosphate synthase BF33_352 ENOG4105CHM Aminotransferase BF33_3520 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BF33_3522 ENOG4105ETU transcriptional activator (TenA BF33_3526 ENOG41080XQ Signal transduction protein with cbs domains BF33_354 ENOG4108HGU Histidine kinase BF33_3552 ENOG4105E2Z phosphate ABC transporter (Permease BF33_3553 ENOG4105C8U phosphate abc transporter BF33_3554 ENOG4105CVA phosphate BF33_3555 ENOG4105CE1 Ferrous iron transport protein b BF33_3556 ENOG4105CE1 Ferrous iron transport protein b BF33_3557 ENOG4105CE1 Ferrous iron transport protein b BF33_3558 ENOG4108NHD germination protein BF33_3561 ENOG4105E1V na solute symporter BF33_3562 ENOG4106CAD Protein of unknown function (DUF3311) BF33_3565 ENOG4105E2S oxidase) subunit II BF33_3566 ENOG4105BZ9 Cytochrome C oxidase, subunit I BF33_3571 ENOG4105MA6 gCN5-related N-acetyltransferase BF33_3574 ENOG4105C7N Xanthine uracil vitamin C permease BF33_3575 ENOG4105C85 amino acid BF33_3579 ENOG4105DUX Transporter BF33_3581 ENOG4107D63 BF33_3582 ENOG4105VZ8 Transcriptional regulator BF33_3583 ENOG41069ER domain protein BF33_3584 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BF33_3596 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BF33_3597 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BF33_3598 ENOG4105CNN ABC, transporter BF33_3599 ENOG4105C2J ABC transporter BF33_36 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BF33_3601 ENOG4108RVA ribokinase BF33_3602 ENOG4105ETE Transcriptional regulator (LacI family BF33_3603 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF33_3604 ENOG41067TZ transcriptional regulator, MarR family BF33_3605 ENOG4105CXY transporter BF33_3607 ENOG4108JQ7 (ABC) transporter BF33_3608 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF33_3610 ENOG4105DEF Extracellular solute-binding protein, family 5 BF33_3612 ENOG41068KF Universal stress protein BF33_3613 ENOG4105CHH sulfate transporter BF33_3616 ENOG4105BZU Histidine kinase BF33_3617 ENOG4105NAE bifunctional deaminase-reductase domain protein BF33_3618 ENOG4105D29 Helix-turn-helix type 11 domain protein BF33_3620 ENOG4105GFR rna polymerase sigma factor BF33_3623 ENOG4108IQI permease BF33_3624 ENOG4105DRP amino acid AbC transporter BF33_3625 ENOG4105EAD ABC transporter BF33_3626 ENOG4105CT1 (ABC) transporter BF33_3627 ENOG4105CDA abc transporter atp-binding protein BF33_3628 ENOG4105BZG amino acid carrier protein BF33_3629 ENOG4105CRN Aminoglycoside phosphotransferase BF33_3631 ENOG4105E1K spore germination protein BF33_3634 ENOG4105CG3 alpha amylase, catalytic region BF33_3635 ENOG4105C5Y PTS System BF33_3636 ENOG4107414 GntR family transcriptional regulator BF33_3637 ENOG4105D5Q Arginine ornithine antiporter BF33_3638 ENOG4105BZU Histidine kinase BF33_3641 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF33_3642 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BF33_3643 ENOG4107T89 von Willebrand factor, type A BF33_3645 ENOG4105EXW epimerase dehydratase BF33_3647 ENOG4105E0A ABC, transporter BF33_3648 ENOG4108IHU transport system permease protein BF33_3649 ENOG4105DQ5 transport system permease protein BF33_365 ENOG4105UIN BF33_3650 ENOG4108MES Periplasmic binding protein BF33_3651 ENOG4105DUX Transporter BF33_3654 ENOG4105DAA L-lactate BF33_3655 ENOG4108IJ0 Aspartate ammonia-lyase BF33_3656 ENOG4105C37 (CBS) domain BF33_3657 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BF33_3658 ENOG4105D9N nucleoside BF33_3659 ENOG4108KGH TRANSCRIPTIONal BF33_3660 ENOG41073R8 VanW family BF33_3667 ENOG4105DAP Nicotinate phosphoribosyltransferase BF33_3668 ENOG4105C59 p-type ATPase BF33_367 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BF33_3670 ENOG4105CUB amino acid BF33_3674 ENOG4108JB9 formate dehydrogenase BF33_3675 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BF33_3676 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BF33_3678 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF33_3679 ENOG4105BZU Histidine kinase BF33_3681 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF33_3682 ENOG4108UZ3 Transporter BF33_3684 ENOG4105C6K Malic enzyme BF33_3686 ENOG4108MRH transcriptional regulatory protein BF33_3691 ENOG4105US7 Histidine kinase BF33_3692 ENOG4108STX response regulator BF33_3693 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BF33_3694 ENOG4105BZ7 extracellular solute-binding protein family 1 BF33_3695 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BF33_3696 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BF33_3697 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF33_3698 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BF33_370 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BF33_3702 ENOG4105D4T Citrate transporter BF33_3703 ENOG4108V9W transcriptional regulatory protein BF33_3704 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BF33_3706 ENOG4105DZ6 Band 7 protein BF33_3709 ENOG4105C94 Transporter BF33_371 ENOG4105EPM Diguanylate phosphodiesterase BF33_3713 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BF33_3735 ENOG4105CAR Terminase, large subunit BF33_374 ENOG4107IN1 Protein of unknown function (DUF1797) BF33_3741 ENOG410682Q Phage transcriptional regulator, ArpU BF33_3750 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BF33_3755 ENOG4105CDU Replicative dna helicase BF33_376 ENOG4108XRC Protein of unknown function (DUF458) BF33_3763 ENOG4108IMY Transcriptional regulator BF33_3769 ENOG4105CYN Serine protein kinase BF33_3771 ENOG4105BZU Histidine kinase BF33_3772 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BF33_3774 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BF33_3776 ENOG4107ZQN disulfide bond BF33_3777 ENOG4108JQC penicillin-binding protein 1A BF33_38 ENOG4105KTH gatB Yqey BF33_3801 ENOG4105G5W regulator Fur family BF33_3802 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BF33_3806 ENOG4108IUW ABC transporter BF33_3808 ENOG4105CBC glutamate synthase BF33_3809 ENOG4107NBY Membrane BF33_3810 ENOG4105BZ1 (ABC) transporter BF33_3814 ENOG4106BXE BF33_3815 ENOG4105CEN a g-specific adenine glycosylase BF33_3816 ENOG41067AE Membrane-bound metal-dependent hydrolase BF33_3822 ENOG4105ECP epimerase BF33_3823 ENOG4105CI2 imidazolone-5-propionate hydrolase BF33_3827 ENOG4105F1A Pyruvate formate-lyase BF33_383 ENOG4107ZYR domain protein BF33_3830 ENOG4105C3I Nad-dependent epimerase dehydratase BF33_3831 ENOG4107QQG Dehydrogenase BF33_3832 ENOG4105CKK Glycosyl transferase, family 2 BF33_3835 ENOG4108A04 Beta-lactamase BF33_3837 ENOG4105CSV Glutaminase BF33_384 ENOG4105CN5 Metallo-Beta-Lactamase BF33_3844 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BF33_3845 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BF33_3852 ENOG4105UPD Calcium Proton BF33_3853 ENOG410606W general stress protein BF33_3856 ENOG4107ZTW SNARE associated Golgi BF33_386 ENOG4108X4Q Hydrolase BF33_3861 ENOG4108IPJ Membrane BF33_3862 ENOG4105C59 p-type ATPase BF33_3863 ENOG4107U9T Pfam:Ribonuclease_BN BF33_3865 ENOG4105KJF protein tyrosine phosphatase BF33_3869 ENOG4108TTB tellurium resistance protein BF33_387 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BF33_3870 ENOG4107TS3 membrane protein, TerC BF33_3871 ENOG4106FN3 tellurium resistance protein BF33_3872 ENOG4106FN3 tellurium resistance protein BF33_3873 ENOG4108N0M stress protein BF33_3879 ENOG4105DEU major facilitator superfamily BF33_3883 ENOG41062JF Transcriptional regulator BF33_3890 ENOG4105C5H ABC transporter BF33_3893 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BF33_3896 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BF33_39 ENOG41068P3 sporulation protein YqfC BF33_390 ENOG4105CPP Dehydrogenase, E1 component BF33_3902 ENOG4105CI1 PTS System BF33_3906 ENOG4105C5B carbamate kinase BF33_3911 ENOG4105C8Q Methyl-accepting chemotaxis BF33_3913 ENOG4105EAB amino acid AbC transporter BF33_3914 ENOG4105E5Q amino acid AbC transporter BF33_3917 ENOG4105D2S major facilitator superfamily BF33_3918 ENOG410756H nucleotidyltransferase BF33_3926 ENOG4106UIA BF33_3927 ENOG4106UIA BF33_3931 ENOG4108V5C ABC transporter BF33_3932 ENOG4105DQ5 transport system permease protein BF33_3933 ENOG4105EHG Permease protein BF33_3934 ENOG4107W7X Aldolase BF33_3936 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BF33_3937 ENOG4105D3R alkyl hydroperoxide reductase BF33_3942 ENOG4105DFD Na H antiporter BF33_3943 ENOG4105DTQ mandelate racemase muconate lactonizing BF33_3946 ENOG4108W15 Protein of unknown function (DUF1456) BF33_3949 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BF33_3950 ENOG4105D9N nucleoside BF33_3954 ENOG4105KPY Small multidrug resistance protein BF33_3955 ENOG4105C26 Dehydrogenase BF33_3957 ENOG4108JPW Aminotransferase BF33_3958 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BF33_3959 ENOG4105CBD Diacylglycerol kinase BF33_3963 ENOG4107I77 yiaA/B two helix domain BF33_3964 ENOG410834F Transcriptional regulator BF33_3968 ENOG4105D01 (LipO)protein BF33_3969 ENOG4108UMI ABC transporter, permease BF33_3970 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF33_3971 ENOG4108W2Y isochorismatase BF33_3977 ENOG4105C4R Atp-dependent dna helicase BF33_3982 ENOG4105C12 Phosphoribosylglycinamide synthetase BF33_3984 ENOG4108V3E phosphoribosylglycinamide formyltransferase BF33_3989 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BF33_3991 ENOG4105C83 adenylosuccinate lyase BF33_3992 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BF33_3993 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BF33_3999 ENOG4105SX7 Transporter BF33_400 ENOG4105CXN decarboxylase BF33_4004 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF33_4013 ENOG4107ZXU DSBA oxidoreductase BF33_4019 ENOG4105BZU Histidine kinase BF33_4021 ENOG4105C7N Xanthine uracil vitamin C permease BF33_4025 ENOG4108TYN CAAX amino terminal protease family protein BF33_4028 ENOG4105C5H ABC transporter BF33_4029 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BF33_4030 ENOG410801F ribosomal-protein-alanine acetyltransferase BF33_4031 ENOG41072GX Peptidase M22 Glycoprotease BF33_4032 ENOG4105K8N protein family UPF0079, ATPase BF33_404 ENOG4105ECY inositol monophosphatase BF33_4052 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BF33_4054 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BF33_4055 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BF33_4058 ENOG4107ZXI Rhomboid family BF33_406 ENOG4105CI3 gtp-binding protein typa BF33_4060 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BF33_4061 ENOG4105CPF Cell wall formation (By similarity) BF33_4062 ENOG4108SC4 )-transporter BF33_4064 ENOG4105ERH Fumarylacetoacetate hydrolase BF33_4065 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BF33_407 ENOG4105QA2 BF33_4071 ENOG410667J hydrolase BF33_4072 ENOG4108JQ7 (ABC) transporter BF33_4073 ENOG4105C3U ABC transporter BF33_4074 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF33_4076 ENOG4105DEF Extracellular solute-binding protein, family 5 BF33_4079 ENOG4108KYE ABC-2 type transporter BF33_4080 ENOG41090VJ ABC-2 type transporter BF33_4081 ENOG4105CJ1 ABC, transporter BF33_4082 ENOG4105WH1 Two component transcriptional regulator luxr family BF33_4083 ENOG4105BZU Histidine kinase BF33_4084 ENOG4105C5H ABC transporter BF33_4088 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BF33_4089 ENOG4108RE7 deoxyribonuclease BF33_4092 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BF33_4096 ENOG4105F6E Acyl-transferase BF33_41 ENOG4105C9A Phoh family BF33_4103 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BF33_4104 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BF33_4105 ENOG4105E0C molybdate abc transporter BF33_4107 ENOG4107XDY Nicotinamide Mononucleotide Transporter BF33_4108 ENOG4105II7 pyrroline-5-carboxylate reductase BF33_411 ENOG4108IAB Phoh family BF33_4110 ENOG4108J59 Extracellular solute-binding protein, family 5 BF33_4111 ENOG4108J59 Extracellular solute-binding protein, family 5 BF33_4113 ENOG4105U5Y Transcriptional regulator BF33_4118 ENOG4108JQ7 (ABC) transporter BF33_4119 ENOG4105C3U ABC transporter BF33_4120 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF33_4121 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF33_4124 ENOG4105C2C drug resistance transporter, Bcr CflA BF33_4127 ENOG4105IQ5 FAD linked oxidase domain protein BF33_4129 ENOG4105EE1 crotonyl-CoA reductase BF33_4130 ENOG4105D01 (LipO)protein BF33_4131 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF33_4132 ENOG4108UMI ABC transporter, permease BF33_4133 ENOG4108PSK reductase BF33_4139 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BF33_414 ENOG4105CNI cell division protein FtsW BF33_4140 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BF33_4142 ENOG4105CMG Carbohydrate kinase BF33_4144 ENOG4108VQT Alpha beta hydrolase fold protein BF33_4148 ENOG4107U5W ybbr family BF33_4149 ENOG4105C8B TIGR00159 family BF33_415 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BF33_4166 ENOG4108NMV polysaccharide deacetylase BF33_4169 ENOG4105D1F ATP-binding protein BF33_4174 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BF33_4175 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BF33_4176 ENOG4108JJB ABC transporter BF33_4182 ENOG41067V7 50S ribosomal protein L36 BF33_4184 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BF33_4186 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BF33_4191 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BF33_42 ENOG4105CTJ Metal Dependent Phosphohydrolase BF33_4212 ENOG4105XPM ribosomal protein BF33_4215 ENOG4107Y49 methyltransferase BF33_4220 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BF33_4222 ENOG4105QIV RNA polymerase BF33_4223 ENOG4105M0M Tetracycline resistance protein BF33_4224 ENOG4105C2N RNA methyltransferase TrmH family group 3 BF33_4227 ENOG4105D7W serine acetyltransferase BF33_4231 ENOG4105CTP PilT protein domain protein BF33_4233 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BF33_4236 ENOG4108Z0C Uvrb UvrC protein BF33_424 ENOG4105EKQ RNA-directed DNA polymerase BF33_4256 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BF33_4258 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BF33_4259 ENOG4105KRF dihydroneopterin aldolase BF33_4260 ENOG4105EEI dihydropteroate synthase BF33_4261 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BF33_4262 ENOG4105DDQ anthranilate synthase BF33_4263 ENOG4105CRQ synthase (Component I) BF33_4264 ENOG4105C6T cysteine synthase BF33_4267 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BF33_4268 ENOG4108UGV hypoxanthine phosphoribosyltransferase BF33_427 ENOG4106UY4 Inherit from COG: Scp-like extracellular BF33_4273 ENOG41060GV RNA binding s1 domain protein BF33_4276 ENOG4105VYY sporulation protein yabp BF33_4277 ENOG41082I2 s4 domain protein BF33_4278 ENOG4108IY2 MazG family BF33_4280 ENOG4108M14 stage v sporulation protein t BF33_4281 ENOG4108JA2 transcriptioN-repair coupling factor BF33_4284 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BF33_4287 ENOG4105KME endoribonuclease L-psp BF33_4288 ENOG4105DFT pur operon repressor BF33_4291 ENOG4105W42 Veg protein BF33_4292 ENOG4105XFA sporulation peptidase YabG BF33_4294 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BF33_4295 ENOG4105F8V Hydrolase, tatD family BF33_4297 ENOG4105KRN Transcriptional regulator, abrb family BF33_4298 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BF33_430 ENOG4107TB6 phosphoglycerate mutase BF33_4300 ENOG41060K3 Methyltransferase BF33_4302 ENOG4105MA4 psp1 domain protein BF33_4303 ENOG4105FA2 dna polymerase iii BF33_4305 ENOG4105CXN decarboxylase BF33_4313 ENOG41067KS pro-sigma K processing BF33_4317 ENOG4105C6E dna polymerase iii BF33_4318 ENOG4108Z6B deaminase BF33_4319 ENOG4105GTG Isochorismatase BF33_4321 ENOG4105ZMH deoxynucleoside kinase BF33_4328 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BF33_4336 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BF33_4339 ENOG410848D S4 domain protein YaaA BF33_434 ENOG4106H78 methyltransferase BF33_4340 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BF33_4344 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BF33_4346 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BF33_435 ENOG4105H20 Sporulation integral membrane protein YlbJ BF33_4350 ENOG4107QJE Chromosome Partitioning Protein BF33_4351 ENOG4105FA0 parb-like partition protein BF33_4352 ENOG4108ZDA Sporulation protein YyaC BF33_4353 ENOG4105D8X mechanosensitive ion channel BF33_4354 ENOG4105VDK protein, conserved in bacteria BF33_4355 ENOG4105C3G gtp-binding protein BF33_4357 ENOG4108UUM single-stranded DNA-binding protein BF33_4359 ENOG4108XMW Membrane BF33_4360 ENOG4105BZR domain protein BF33_4362 ENOG4105CDU Replicative dna helicase BF33_4368 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF33_4369 ENOG4105BZU Histidine kinase BF33_437 ENOG4105D78 K07001 NTE family protein BF33_4372 ENOG4105Q2H domain protein BF33_4373 ENOG4105C0H protease BF33_4377 ENOG4105DPN Oligoendopeptidase f BF33_438 ENOG41063PX domain protein BF33_4380 ENOG4105C1J atp-dependent rna helicase BF33_4382 ENOG4108UT2 hemolysin iii BF33_4383 ENOG4105CMR udp-glucose 4-epimerase BF33_4385 ENOG4105IW1 AmiS UreI transporter BF33_4387 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF33_4390 ENOG4107RGD Major Facilitator superfamily BF33_4391 ENOG4108HRK Histidine kinase BF33_4392 ENOG4105DY9 regulatoR BF33_4395 ENOG4106F5Q Membrane BF33_4396 ENOG4105E0X reductase BF33_4398 ENOG41067SE Tetr family transcriptional regulator BF33_4399 ENOG4105CKK Glycosyl transferase, family 2 BF33_44 ENOG4107YR5 Diacylglycerol kinase BF33_440 ENOG4105KNH Nucleic acid-binding protein BF33_4403 ENOG4105C5H ABC transporter BF33_4404 ENOG4105JEU Glycosyl transferase, family 2 BF33_4406 ENOG4108S4H thioesterase Superfamily protein BF33_4408 ENOG4106YBV Methyl-accepting chemotaxis BF33_4409 ENOG4105EN6 Membrane BF33_4413 ENOG41079KZ Major Facilitator Superfamily BF33_4414 ENOG4105DY9 regulatoR BF33_4415 ENOG4105D22 carbon starvation protein BF33_4416 ENOG4105VCD cytoplasmic protein BF33_4417 ENOG4105BZU Histidine kinase BF33_4418 ENOG4105DWF phosphomethylpyrimidine kinase BF33_4419 ENOG4105BZU Histidine kinase BF33_4420 ENOG4105WH1 Two component transcriptional regulator luxr family BF33_4422 ENOG4108Y4K DNA-binding transcriptional activator BF33_4427 ENOG4105D6E homoserine dehydrogenase BF33_4430 ENOG41090WU lipolytic protein G-D-S-L family BF33_4431 ENOG4105CJ1 ABC, transporter BF33_4432 ENOG4108TU7 Inherit from COG: (ABC) transporter BF33_4434 ENOG4105VCH membrane BF33_4435 ENOG410667J hydrolase BF33_4437 ENOG4107SVH Potassium channel protein BF33_4441 ENOG4108VKI Cell wall hydrolase BF33_4444 ENOG4108IJ2 phosphate acetyltransferase BF33_4448 ENOG4108VCI transcription factor, rsfa family BF33_4450 ENOG4105DQ5 transport system permease protein BF33_4451 ENOG4105EHG Permease protein BF33_4452 ENOG4105E0A ABC, transporter BF33_4453 ENOG4108MES Periplasmic binding protein BF33_4454 ENOG4105DCI Phosphohydrolase BF33_4455 ENOG41069HH 4-oxalocrotonate tautomerase BF33_4456 ENOG4108Z4T Peptidase M50 BF33_4457 ENOG4108XFG YwhD family BF33_4458 ENOG4105BZ4 penicillin-binding protein BF33_4459 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BF33_4460 ENOG4107SWG transcriptional regulator MERR family BF33_4461 ENOG4105DXB Major Facilitator superfamily BF33_4463 ENOG4105CYW agmatinase BF33_4467 ENOG410684U Domain of unknown function (DUF1934) BF33_4469 ENOG4105EMN RNA polymerase sigma factor BF33_447 ENOG41068DC Essential cell division protein (By similarity) BF33_4473 ENOG4105IIU Aminopeptidase BF33_4475 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BF33_4476 ENOG4108M15 ABC transporter BF33_448 ENOG4105CJN penicillin-binding protein BF33_4480 ENOG4105BZU Histidine kinase BF33_4483 ENOG4105DF6 Fe-S oxidoreductase BF33_4485 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BF33_4486 ENOG4105C1G acyl-Coa dehydrogenase BF33_4487 ENOG4105C1G acyl-Coa dehydrogenase BF33_449 ENOG4105CJN penicillin-binding protein BF33_4494 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BF33_4495 ENOG4105CBT Fructose-1,6-bisphosphatase BF33_4496 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BF33_4499 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BF33_45 ENOG4105KG3 cytidine deaminase BF33_450 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BF33_4500 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BF33_4501 ENOG4108ZXQ stage ii sporulation protein r BF33_4503 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BF33_4506 ENOG4107XC4 flavin reductase domain protein, FMN-binding BF33_4507 ENOG4108VGI doxx family BF33_4510 ENOG4108YZG isomerase BF33_4515 ENOG41062M3 atp synthase BF33_4516 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BF33_4526 ENOG4105BZU Histidine kinase BF33_4527 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BF33_4529 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BF33_453 ENOG4105CNI cell division protein FtsW BF33_4530 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BF33_4535 ENOG4105D65 subunit l BF33_4536 ENOG4105C8S subunit m BF33_4537 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BF33_4538 ENOG4106778 Protein of unknown function (DUF1146) BF33_454 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BF33_4542 ENOG4105DY9 regulatoR BF33_4545 ENOG4105FRN stage II sporulation protein BF33_4546 ENOG4107BJW polysaccharide deacetylase BF33_4547 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BF33_4549 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase BF33_455 ENOG4105D4A Cell wall formation (By similarity) BF33_4550 ENOG4107RZX Teichoic acid biosynthesis protein BF33_4551 ENOG4107SJB teichoic acid biosynthesis BF33_4552 ENOG4107SJB teichoic acid biosynthesis BF33_4554 ENOG4105EY8 ABC transporter BF33_4555 ENOG4107VDP teichoic acid biosynthesis BF33_4556 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BF33_4559 ENOG4105CMR udp-glucose 4-epimerase BF33_456 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BF33_4560 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF33_4561 ENOG4105BZU Histidine kinase BF33_4564 ENOG4105CXY transporter BF33_4566 ENOG4105C19 ABC transporter BF33_4567 ENOG4107RBB ABC transporter, permease BF33_457 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BF33_4570 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF33_4576 ENOG4105C0D helicase BF33_4577 ENOG4105KBK Zinc finger, swim domain protein BF33_458 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BF33_4582 ENOG41069ER domain protein BF33_4583 ENOG4105C94 Transporter BF33_4585 ENOG4107R8N Glycosyl transferase, family 2 BF33_4590 ENOG4105E0M Sulfatase BF33_4592 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) BF33_4594 ENOG4105DAA L-lactate BF33_4596 ENOG4105DAA L-lactate BF33_46 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BF33_460 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF33_4603 ENOG4107RSM transcriptional regulator BF33_4604 ENOG4105ECB domain protein BF33_4605 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BF33_4608 ENOG4105VZJ PTS System BF33_4610 ENOG4105VCP PTS System BF33_4612 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BF33_4614 ENOG4105CK1 PTS System BF33_4615 ENOG4105VCP PTS System BF33_4616 ENOG4105F8D glycoside hydrolase family 4 BF33_462 ENOG4105WR5 sporulation protein, YlmC YmxH family BF33_4620 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BF33_4621 ENOG4108ZJ4 polysaccharide deacetylase BF33_4622 ENOG4105ESV Glycosyl transferase, family 4 BF33_4623 ENOG4105C6Y Udp-glucose 6-dehydrogenase BF33_4624 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BF33_4625 ENOG4108KGH TRANSCRIPTIONal BF33_4626 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BF33_4628 ENOG4105KVH Transcriptional regulator BF33_463 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BF33_4631 ENOG41081UC Inherit from COG: Competence protein BF33_4632 ENOG4105VEQ Cold shock protein BF33_4633 ENOG4105MS2 ribosomal subunit Interface protein BF33_4635 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BF33_4637 ENOG4105CAK Cell division ATP-binding protein ftsE BF33_4638 ENOG4105CRP Part of the ABC transporter FtsEX involved in BF33_4639 ENOG4105CN1 protease BF33_464 ENOG4105DFA alanine racemase domain protein BF33_4641 ENOG4105BZ1 (ABC) transporter BF33_4644 ENOG4108WS4 fmn reductase BF33_4646 ENOG4105DUM transcriptional regulator, lysR family BF33_4647 ENOG4105HMI Membrane BF33_4653 ENOG4107TXC Transcriptional regulator BF33_4656 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BF33_4657 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF33_4659 ENOG41086DT Membrane protein of unknown function BF33_466 ENOG41067XK integral membrane protein BF33_4663 ENOG4108S4C acetyltransferase BF33_4665 ENOG4105C3M thioredoxin reductase BF33_4667 ENOG4108Z4K mutator MutT protein BF33_4669 ENOG4105CHW UPF0052 protein BF33_467 ENOG4105DBK s4 domain protein BF33_4671 ENOG4105KRI phosphocarrier protein (HPr BF33_4672 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BF33_4673 ENOG4105H67 Protein of unknown function (DUF421) BF33_4676 ENOG4105CZ3 stage V sporulation protein ad BF33_4677 ENOG41090VF Stage v sporulation protein ac BF33_4681 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF33_4687 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BF33_4691 ENOG41067MG lrgb family BF33_4692 ENOG4105XZU Preprotein translocase, subunit SecG BF33_4694 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BF33_4700 ENOG4105CM4 permease protein BF33_4701 ENOG4108IPW abc transporter atp-binding protein BF33_4704 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BF33_4705 ENOG4108MK9 spermidine N(1)-acetyltransferase BF33_4711 ENOG4105C8Q Methyl-accepting chemotaxis BF33_4715 ENOG4105D4A Cell wall formation (By similarity) BF33_4716 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BF33_4719 ENOG4105KVH Transcriptional regulator BF33_472 ENOG4105C34 Pseudouridine synthase BF33_4720 ENOG4105F27 Major Facilitator BF33_4721 ENOG4105CV8 reductase BF33_4725 ENOG4108RYK Nad-dependent epimerase dehydratase BF33_4727 ENOG4105D9N nucleoside BF33_4728 ENOG4105D9N nucleoside BF33_4732 ENOG4108URH decarboxylase BF33_4735 ENOG4108RMU ferritin dps family protein BF33_4737 ENOG4105NCW Trka-c domain protein BF33_4738 ENOG4107S91 Sodium hydrogen exchanger BF33_4742 ENOG4105D4Y metalloprotease BF33_4743 ENOG4105VG1 fes assembly suf system protein BF33_4744 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BF33_4745 ENOG4105C8Q Methyl-accepting chemotaxis BF33_4749 ENOG4105BZU Histidine kinase BF33_4750 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF33_4751 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BF33_4753 ENOG4107ZTW SNARE associated Golgi BF33_4761 ENOG4107AYK membrAne BF33_4763 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BF33_4765 ENOG4107R7I amino acid BF33_4766 ENOG4108SUT Major Facilitator Superfamily BF33_477 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BF33_4770 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BF33_4774 ENOG4105DZ1 carboxypeptidase BF33_4777 ENOG4105CHU acetyl-coa acetyltransferase BF33_4778 ENOG4105C1G acyl-Coa dehydrogenase BF33_4779 ENOG4108W8B Beta-lactamase domain protein BF33_4787 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF33_4795 ENOG41080E8 Transcriptional regulator, Spx MgsR family BF33_4801 ENOG4108UMI ABC transporter, permease BF33_4802 ENOG4105D01 (LipO)protein BF33_4803 ENOG4105D01 (LipO)protein BF33_4804 ENOG4105C3K feS assembly ATPase SufC BF33_4805 ENOG4105JRK feS assembly protein SufD BF33_4806 ENOG4105C9B Cysteine desulfurase BF33_4807 ENOG4108UNV SUF system FeS assembly protein, NifU family BF33_4808 ENOG4105DIW FeS assembly protein SUFB BF33_4809 ENOG4107R8B 5'-nucleotidase BF33_4810 ENOG4105KZD Domain of unknown function (DUF1805) BF33_4812 ENOG4105FAA peptidase M23 BF33_4817 ENOG41090T1 Membrane BF33_4818 ENOG4107TXC Transcriptional regulator BF33_4819 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BF33_4820 ENOG4105MMD transcriptional regulator BF33_4823 ENOG4105CBT Fructose-1,6-bisphosphatase BF33_4826 ENOG4105D4U had-superfamily hydrolase, subfamily iia BF33_4828 ENOG4105DYS nad(p)h dehydrogenase (quinone) BF33_4830 ENOG4108W5N phosphatidylglycerophosphatase a BF33_4833 ENOG41083MR nifu domain-containing protein BF33_4838 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BF33_4839 ENOG4105C4B ABC transporter, permease BF33_4840 ENOG4108JJA ABC, transporter BF33_4844 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BF33_4846 ENOG4105EWC Purine nucleoside phosphorylase BF33_4852 ENOG4105CEP NADH dehydrogenase BF33_4855 ENOG41069ER domain protein BF33_4859 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BF33_4862 ENOG4105KA0 thioesterase Superfamily protein BF33_4863 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BF33_4866 ENOG4107R3E Citrate transporter BF33_4868 ENOG4105Y38 Kinase-associated protein B BF33_4871 ENOG4105C87 Aminotransferase class I and II BF33_4873 ENOG4108MUZ hydrolase BF33_4874 ENOG4105C5I Dehydrogenase BF33_4875 ENOG4108ZB6 transcriptional regulator AsnC family BF33_4876 ENOG4105CHM Aminotransferase BF33_4878 ENOG4105WG9 Conserved Protein BF33_488 ENOG4105DC7 peptidase M24 BF33_4880 ENOG4107PBV potassium channel BF33_4882 ENOG4105KT7 mgtC SapB transporter BF33_489 ENOG4105F23 Fibronectin-binding protein BF33_4890 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BF33_4909 ENOG4105JVQ RNA Polymerase BF33_491 ENOG4105DSJ YicC domain protein BF33_4911 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF33_4914 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BF33_4921 ENOG4105VEQ Cold shock protein BF33_4923 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BF33_4924 ENOG4105E4F Isochorismate synthase BF33_4926 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BF33_4927 ENOG4108IPT Naphthoate synthase BF33_4929 ENOG4105DTQ mandelate racemase muconate lactonizing BF33_4935 ENOG41069H0 dihydroorotase EC 3.5.2.3 BF33_4939 ENOG4105FDP GntR family transcriptional regulator BF33_4940 ENOG4105C6Z Gluconate BF33_4949 ENOG41086D8 Transcriptional regulator BF33_495 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BF33_4950 ENOG4105C19 ABC transporter BF33_4953 ENOG4107ZTW SNARE associated Golgi BF33_4958 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BF33_4959 ENOG4108UGV hypoxanthine phosphoribosyltransferase BF33_496 ENOG4105C25 Primosomal protein n' BF33_4964 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF33_4965 ENOG4105BZU Histidine kinase BF33_497 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BF33_4973 ENOG41087YS Phage shock protein A BF33_4982 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BF33_4983 ENOG4105C4M (Ubiquinol oxidase) subunit I BF33_4985 ENOG4108V2W Carbonate dehydratase BF33_499 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BF33_4993 ENOG4107XGZ Hydrolase BF33_4996 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BF33_4998 ENOG4105D2X ABC transporter substrate-binding protein BF33_5001 ENOG4107T7U Sulfatase BF33_5002 ENOG4107S9D Alpha beta hydrolase BF33_5003 ENOG4105BZU Histidine kinase BF33_5004 ENOG4105BZU Histidine kinase BF33_5005 ENOG4105EGD dinuclear metal center protein, YbgI family BF33_501 ENOG4108ZF3 Phosphatase BF33_5015 ENOG4108RIR Molybdenum cofactor biosynthesis protein BF33_5017 ENOG4105BZF Glycosyl transferase (Group 1 BF33_5018 ENOG4105YVM Phosphoesterase, PA-phosphatase related BF33_5019 ENOG4108Z0R Transferase BF33_502 ENOG4105D9P serine threonine protein kinase BF33_5020 ENOG4105E8V Alpha Beta Hydrolase Fold protein BF33_5026 ENOG4105CIG ABC transporter BF33_5028 ENOG4105N5T Radical SAM Protein BF33_503 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BF33_5032 ENOG4105C19 ABC transporter BF33_5035 ENOG4105NCW Trka-c domain protein BF33_5036 ENOG4107S91 Sodium hydrogen exchanger BF33_5037 ENOG410605W Major Facilitator BF33_504 ENOG4105DJV ribulose-phosphate 3-epimerase BF33_5043 ENOG4108B31 Spore germination protein BF33_5045 ENOG4105DWV Homoserine O-trans-acetylase BF33_5047 ENOG41085GJ domain protein BF33_505 ENOG4105FJ0 thiamine BF33_5051 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BF33_5052 ENOG4105D06 uba thif-type nad fad binding protein BF33_5054 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF33_5055 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BF33_5056 ENOG4108ZAF Molybdopterin BF33_5060 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BF33_5061 ENOG4108VJ1 Transcriptional regulator (CarD family BF33_5068 ENOG4105CBX hi0933 family BF33_507 ENOG4108ZAA Alkaline-shock protein BF33_5071 ENOG4105YW5 deoR family transcriptional regulator BF33_5072 ENOG4107QSE Dipeptidase BF33_5074 ENOG4108IUM Glycogen debranching enzyme BF33_5075 ENOG4108V15 phosphotransferase enzyme family BF33_5078 ENOG4105C8F Beta-lactamase domain protein BF33_508 ENOG4105DP4 dak2 domain fusion protein ylov BF33_5084 ENOG4108VDD TRNA binding domain protein BF33_509 ENOG4105CB5 ATP-dependent DNA helicase recG BF33_5093 ENOG4105C88 aminopeptidase BF33_5097 ENOG4105ETE Transcriptional regulator (LacI family BF33_51 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BF33_5103 ENOG4105EP9 oxidoreductase BF33_5104 ENOG4107SNB ankyrin repeat protein YahD BF33_5105 ENOG4105BZU Histidine kinase BF33_5106 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF33_5108 ENOG4106HB6 Alpha beta hydrolase BF33_5109 ENOG4105DGU Histone deacetylase BF33_5110 ENOG4105W87 Cbs domain BF33_5111 ENOG4105F1V Acetoin utilization protein BF33_5114 ENOG4105EMN RNA polymerase sigma factor BF33_5116 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BF33_512 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BF33_5120 ENOG4105C28 cystathionine BF33_5122 ENOG4105U5Y Transcriptional regulator BF33_5124 ENOG4106KR7 LysR family Transcriptional regulator BF33_5129 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BF33_513 ENOG4105CHR reductase BF33_5131 ENOG4105EFZ amidohydrolase BF33_5134 ENOG4105KBJ sporulation protein ytfj BF33_5135 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BF33_5141 ENOG4108JYZ YitT family BF33_5150 ENOG4107YZX Universal stress protein BF33_5154 ENOG4105VZ8 Transcriptional regulator BF33_5156 ENOG41082W1 Cupin 2, conserved barrel domain protein BF33_516 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BF33_5165 ENOG4105DC7 peptidase M24 BF33_517 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BF33_5172 ENOG4105SFS phosphoesterase RecJ domain protein BF33_5174 ENOG4105VV2 BF33_5175 ENOG4105C0B DNA polymerase III (alpha subunit) BF33_5176 ENOG4105C6K Malic enzyme BF33_5177 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BF33_5182 ENOG4105FS0 cytoplasmic membrane protein BF33_5183 ENOG4108REF Sporulation integral membrane protein ytvi BF33_5185 ENOG4105BZN citrate synthase BF33_5186 ENOG4108HMX isocitrate dehydrogenase (NADP) BF33_5191 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF33_5192 ENOG4105BZU Histidine kinase BF33_5193 ENOG4105C2M dna polymerase I BF33_5194 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BF33_5196 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BF33_5197 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BF33_5198 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BF33_52 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF33_5202 ENOG4108TDW sporulation protein YtxC BF33_5203 ENOG4105C22 threonyL-tRNA synthetase BF33_5204 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BF33_5208 ENOG4105CN9 Peptidase m42 family protein BF33_5209 ENOG4108JGH Tetr family transcriptional regulator BF33_521 ENOG4105VB6 UPF0109 protein BF33_5210 ENOG4105CW7 secretion protein, HlyD family BF33_5211 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF33_5218 ENOG4108RWN rrna methyltransferase BF33_5220 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BF33_5221 ENOG4105C5S asparaginyl-tRNA synthetase BF33_5228 ENOG4105DCG PHP domain protein BF33_5231 ENOG4105FE9 pseudouridine synthase BF33_5233 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BF33_5235 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BF33_5238 ENOG4105E0A ABC, transporter BF33_5239 ENOG4105KFN sortase, SrtB family BF33_5242 ENOG4105DR4 Methyltransferase BF33_5245 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF33_5253 ENOG4105S6R Iron-hydroxamate transporter permease subunit BF33_5254 ENOG4105J76 Periplasmic binding protein BF33_5256 ENOG4105CEY Amp-dependent synthetase and ligase BF33_5257 ENOG4107Z3H Transcriptional regulator, TetR family BF33_5258 ENOG41060WC Enoyl-CoA hydratase BF33_5259 ENOG4105BZJ Electron transfer flavoprotein BF33_526 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BF33_5260 ENOG4105C10 Electron transfer flavoprotein BF33_5261 ENOG4105K63 Thioredoxin BF33_5264 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BF33_5266 ENOG4105E33 succinate dehydrogenase BF33_5268 ENOG4108VXD carboxy-peptidase BF33_5269 ENOG4105E14 MotA TolQ exbB proton channel BF33_5270 ENOG4105ER2 Ompa motb domain protein BF33_5271 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BF33_5272 ENOG4108IUX (ABC) transporter BF33_5273 ENOG4105RHA ABC transporter, permease BF33_5274 ENOG4108Z40 Transcriptional regulator BF33_5275 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BF33_5277 ENOG4108JCI Transcriptional regulator BF33_5278 ENOG41067S9 phage shock protein C, PspC BF33_5280 ENOG4105DY9 regulatoR BF33_5281 ENOG4108HRK Histidine kinase BF33_5282 ENOG4108JQ7 (ABC) transporter BF33_5285 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF33_5286 ENOG4105DEF Extracellular solute-binding protein, family 5 BF33_5287 ENOG4105DZC cytosine deaminase BF33_5288 ENOG4105DZC cytosine deaminase BF33_529 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BF33_5291 ENOG4105PFC Transcriptional regulator BF33_5296 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BF33_530 ENOG4105C79 DNA protecting protein DprA BF33_5301 ENOG4105D6J arsenicaL-resistance protein BF33_5304 ENOG41082YX Transcriptional regulator, arsr family BF33_5309 ENOG410904A RNA polymerase BF33_531 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BF33_5310 ENOG41089UC methyltransferase, type 11 BF33_5319 ENOG4105KBX Transcriptional regulator, TetR family BF33_5321 ENOG4108PCX Major Facilitator BF33_5323 ENOG4108XJQ germination protein BF33_5325 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BF33_5326 ENOG4105M59 Phosphodiesterase, mj0936 family BF33_533 ENOG4108HE4 integrase family BF33_5330 ENOG4108QCI YvbH-like oligomerisation region BF33_5337 ENOG4108IUQ atp-dependent protease BF33_5341 ENOG4105K56 Transcriptional regulator BF33_5346 ENOG4105D52 delta-aminolevulinic acid dehydratase BF33_5348 ENOG41068KH stage VI sporulation protein D BF33_5350 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BF33_5351 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BF33_5355 ENOG4105DFF Rod shape-determining protein mreb BF33_5356 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BF33_5359 ENOG4107QMS site-determining protein BF33_5362 ENOG4105C03 ribonuclease BF33_5364 ENOG4105X36 (ribosomal) protein BF33_5369 ENOG4105EWM Histidine kinase BF33_5373 ENOG4105CQC Prephenate dehydratase BF33_5374 ENOG4108RPX mosc domain containing protein BF33_5377 ENOG4108IYU L-aspartate oxidase BF33_5378 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BF33_5384 ENOG4108HUF Transporter BF33_5387 ENOG41061AI Protein of unknown function (DUF2905) BF33_5390 ENOG4105VIE preprotein translocase, subunit YajC BF33_5392 ENOG4108QG2 Membrane BF33_5393 ENOG4105CKP Polysaccharide Biosynthesis Protein BF33_5395 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BF33_5396 ENOG41076HS cation diffusion facilitator family transporter BF33_5397 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BF33_5399 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BF33_5403 ENOG4105CUT histidyl-tRNA synthetase BF33_5405 ENOG4105CUZ uba thif-type nad fad binding protein BF33_5406 ENOG4108VCI transcription factor, rsfa family BF33_5407 ENOG4105D1H recombination factor protein RarA BF33_5409 ENOG4105C3J Cysteine desulfurase BF33_5412 ENOG4105C7H Helicase, RecD TraA family BF33_5413 ENOG41060CR BF33_5416 ENOG4105C02 permease BF33_542 ENOG4105KNE Phosphatidate cytidylyltransferase BF33_5422 ENOG4105HHA aminodeoxychorismate lyase BF33_5423 ENOG4108VQJ O-methyltransferase BF33_5424 ENOG4105XYU peptidase (U32 family) BF33_5425 ENOG4105CFP Peptidase U32 BF33_5428 ENOG4107XRG penicillin-binding protein BF33_543 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BF33_5434 ENOG4105C28 cystathionine BF33_5435 ENOG4108EKI Dehydrogenase BF33_5437 ENOG4108V5C ABC transporter BF33_5438 ENOG4105S6R Iron-hydroxamate transporter permease subunit BF33_544 ENOG4105DZP Membrane-associated zinc metalloprotease BF33_5446 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BF33_5448 ENOG4105MIR Phenylalanine 4-monooxygenase BF33_5449 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BF33_5456 ENOG4108MUZ hydrolase BF33_5458 ENOG4105G6Z alkaline phosphatase BF33_5459 ENOG4108B31 Spore germination protein BF33_546 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BF33_5462 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BF33_5463 ENOG4108QY0 Membrane BF33_5466 ENOG4105CZ3 stage V sporulation protein ad BF33_5467 ENOG41090VF Stage v sporulation protein ac BF33_5470 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF33_5473 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BF33_548 ENOG4105CHV Transcription elongation factor NusA BF33_5481 ENOG41086D8 Transcriptional regulator BF33_5486 ENOG4108W2Y isochorismatase BF33_5489 ENOG4108NHD germination protein BF33_549 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BF33_5494 ENOG4107XGZ Hydrolase BF33_5496 ENOG4105YWU small acid-soluble spore protein BF33_55 ENOG4105EGD dinuclear metal center protein, YbgI family BF33_550 ENOG4105VHM ribosomal protein BF33_5501 ENOG4107A6P BF33_5503 ENOG4105EKQ RNA-directed DNA polymerase BF33_5507 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF33_5508 ENOG41089BK Glutamine amido-transferase BF33_5510 ENOG4106J6E BF33_5517 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BF33_552 ENOG4105W7A Protein of unknown function (DUF503) BF33_5536 ENOG4105EKQ RNA-directed DNA polymerase BF33_554 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BF33_555 ENOG4105DTN riboflavin biosynthesis protein ribF BF33_5550 ENOG4105TQK DNA polymerase iii, delta' subunit BF33_5552 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF33_5555 ENOG4105EKQ RNA-directed DNA polymerase BF33_5567 ENOG4105EKQ RNA-directed DNA polymerase BF33_5582 ENOG4105EKQ RNA-directed DNA polymerase BF33_5586 ENOG4105K4H Nlp p60 protein BF33_559 ENOG4105C1V Peptidase, M16 BF33_5593 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BF33_5598 ENOG4105DQ6 Transposase BF33_561 ENOG4105E35 Dipicolinate synthase subunit A BF33_5616 ENOG4105D7V transposase BF33_562 ENOG4108S0H Dipicolinic acid synthetase, b subunit BF33_563 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BF33_5647 ENOG41067QW Transcriptional regulator BF33_565 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BF33_5653 ENOG4105C6E dna polymerase iii BF33_5655 ENOG4105ENA helicase BF33_5656 ENOG4105FA2 dna polymerase iii BF33_5660 ENOG4108TF4 von Willebrand factor, type A BF33_5661 ENOG4105KRN Transcriptional regulator, abrb family BF33_5666 ENOG4105IYK transposase BF33_5667 ENOG4105DQ6 Transposase BF33_5668 ENOG4108VXD carboxy-peptidase BF33_567 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BF33_5675 ENOG4105D6J arsenicaL-resistance protein BF33_5676 ENOG41082YX Transcriptional regulator, arsr family BF33_5680 ENOG4105CKI cobalamin synthesis protein BF33_5681 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BF33_5683 ENOG41067QW Transcriptional regulator BF33_5684 ENOG4105CJ3 phosphate transporter BF33_5685 ENOG41085FC arsR family transcriptional regulator BF33_5688 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes BF33_569 ENOG4107QZI cell division protein FtsK BF33_5698 ENOG4105C59 p-type ATPase BF33_5699 ENOG4105VPX protein, conserved in bacteria BF33_570 ENOG4105FDP GntR family transcriptional regulator BF33_5700 ENOG4105DSE periplasmic solute binding protein BF33_5706 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding BF33_571 ENOG4105DIH basic membrane BF33_572 ENOG4108JQ9 ABC transporter BF33_5724 ENOG4105K63 Thioredoxin BF33_5726 ENOG4105EAB amino acid AbC transporter BF33_5727 ENOG4105E5Q amino acid AbC transporter BF33_5728 ENOG4105CDA abc transporter atp-binding protein BF33_573 ENOG4105UIB (ABC) transporter BF33_5730 ENOG4107R16 Multicopper oxidase BF33_5731 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF33_5732 ENOG4105BZU Histidine kinase BF33_5734 ENOG4108ZRV stage ii sporulation protein p BF33_5744 ENOG4105D9M gamma-glutamylcysteine synthetase BF33_5746 ENOG4105C4W S-formylglutathione hydrolase BF33_5748 ENOG4105KVH Transcriptional regulator BF33_5752 ENOG4105E1K spore germination protein BF33_5756 ENOG4105CDU Replicative dna helicase BF33_577 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BF33_5776 ENOG4105QBX endodeoxyribonuclease RusA BF33_578 ENOG4105XZV Protein of unknown function (DUF3243) BF33_5785 ENOG4108MDF Phage Portal Protein BF33_5786 ENOG4106CGH Phage Mu protein F like protein BF33_5792 ENOG41060SN BF33_5806 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF33_5809 ENOG4105PKS Excinuclease abc c subunit domain protein BF33_581 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BF33_5818 ENOG4107QJE Chromosome Partitioning Protein BF33_5832 ENOG4108NF7 phage-type endonuclease BF33_5833 ENOG4108PNI recT protein BF33_586 ENOG4105D48 metallophosphoesterase BF33_587 ENOG4105MCT stage V sporulation protein S BF33_588 ENOG4108IGT Dipeptidase BF33_589 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BF33_590 ENOG4105DQU oxidoreductase, subunit beta BF33_596 ENOG4107QHE Choloylglycine hydrolase BF33_598 ENOG410890F Dynamin family BF33_599 ENOG4105E0M Sulfatase BF33_60 ENOG41069ZM Protein of unknown function (DUF2624) BF33_600 ENOG4107R6R udp-galactopyranose mutase BF33_601 ENOG4105F0V Cell wall hydrolase BF33_605 ENOG4107YEI lmbE family BF33_606 ENOG4107TTQ Alpha beta hydrolase fold BF33_609 ENOG41067MG lrgb family BF33_61 ENOG4108JYZ YitT family BF33_612 ENOG4105BZU Histidine kinase BF33_613 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BF33_619 ENOG4105D03 DNA-3-methyladenine glycosylase II BF33_62 ENOG4105FDK ABC transporter BF33_620 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BF33_622 ENOG4105CGK Exodeoxyribonuclease III BF33_626 ENOG4105E0A ABC, transporter BF33_627 ENOG4105NIV Esterase BF33_629 ENOG4105VPX protein, conserved in bacteria BF33_630 ENOG410681U heavy metal transport detoxification protein BF33_631 ENOG4105C59 p-type ATPase BF33_632 ENOG4105K70 DNA-binding protein BF33_633 ENOG4105TMB Formate nitrite transporter BF33_637 ENOG4105C85 amino acid BF33_64 ENOG4105N80 Ferric uptake regulator, Fur family BF33_640 ENOG4108SJC Membrane BF33_641 ENOG4107QW4 alcohol dehydrogenase BF33_642 ENOG4105E98 transcriptional regulator DeoR family BF33_643 ENOG4105DE4 1-phosphofructokinase BF33_644 ENOG4105DM4 PTS System BF33_645 ENOG41069ER domain protein BF33_651 ENOG4106F1P AAA ATPase, central domain protein BF33_653 ENOG4105EN6 Membrane BF33_654 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BF33_655 ENOG4105CXI aluminum resistance protein BF33_656 ENOG4105KV4 Transcriptional regulator BF33_657 ENOG4105C5F glutamine synthetase BF33_663 ENOG4105K7K Transcriptional regulator BF33_667 ENOG4108SVB resolvase BF33_669 ENOG4105CGH 5'-nucleotidase BF33_671 ENOG4105D5T phosphonate abc transporter BF33_674 ENOG4105D7V transposase BF33_678 ENOG4105BZ1 (ABC) transporter BF33_679 ENOG4105BZ1 (ABC) transporter BF33_682 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF33_687 ENOG41067MG lrgb family BF33_689 ENOG4107RSM transcriptional regulator BF33_69 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF33_691 ENOG4105CJ1 ABC, transporter BF33_693 ENOG4105CH2 amidohydrolase BF33_695 ENOG4107QIV Cytochrome c biogenesis protein BF33_7 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF33_702 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) BF33_708 ENOG4108903 Formimidoylglutamase BF33_709 ENOG4108VJ1 Transcriptional regulator (CarD family BF33_71 ENOG4107RF6 penicillin-binding protein BF33_710 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BF33_711 ENOG4105CBC glutamate synthase BF33_712 ENOG4105CK7 Sodium proline symporter BF33_713 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BF33_714 ENOG4105FBA Phospholipase Carboxylesterase BF33_715 ENOG4105BZU Histidine kinase BF33_717 ENOG4107AYK membrAne BF33_72 ENOG4105PWN phosphate abc transporter BF33_727 ENOG4105CEY Amp-dependent synthetase and ligase BF33_728 ENOG4107ZYJ bioY protein BF33_729 ENOG4107F3J Amp-dependent synthetase and ligase BF33_73 ENOG4105C8U phosphate abc transporter BF33_733 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF33_735 ENOG4105E5W Transporter BF33_74 ENOG4105E2Z phosphate ABC transporter (Permease BF33_741 ENOG4108I0Z Aconitate hydratase BF33_742 ENOG4108JJA ABC, transporter BF33_744 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BF33_745 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BF33_75 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BF33_751 ENOG4105W8X HesB YadR YfhF-family protein BF33_752 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BF33_753 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BF33_755 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF33_756 ENOG4105C0H protease BF33_757 ENOG4105K4P CoA-binding domain protein BF33_758 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BF33_76 ENOG4108UTW Plays a role in the regulation of phosphate uptake BF33_760 ENOG4105D9R oxidoreductase BF33_762 ENOG4105CIG ABC transporter BF33_766 ENOG4105EMN RNA polymerase sigma factor BF33_768 ENOG4108KGH TRANSCRIPTIONal BF33_769 ENOG4107QJT sodium dicarboxylate symporter BF33_772 ENOG4105DQ6 Transposase BF33_784 ENOG4105E1K spore germination protein BF33_786 ENOG4108JB9 formate dehydrogenase BF33_788 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BF33_789 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BF33_79 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BF33_791 ENOG4105TMB Formate nitrite transporter BF33_792 ENOG4105D06 uba thif-type nad fad binding protein BF33_793 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF33_794 ENOG4108ZAF Molybdopterin BF33_796 ENOG4105D1F ATP-binding protein BF33_799 ENOG4105FR1 rard protein BF33_801 ENOG4105EWU Squalene--hopene cyclase BF33_802 ENOG4105CHR reductase BF33_803 ENOG4105C26 Dehydrogenase BF33_805 ENOG4108IA2 Sodium pantothenate symporter BF33_808 ENOG4106IQC argininosuccinate lyase BF33_81 ENOG4105DKQ ROK family BF33_810 ENOG410904N short-chain dehydrogenase reductase BF33_814 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BF33_818 ENOG4105VEQ Cold shock protein BF33_822 ENOG4108R1P BF33_824 ENOG41073R8 VanW family BF33_825 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BF33_828 ENOG4105KT7 mgtC SapB transporter BF33_83 ENOG4105C5X domain protein BF33_830 ENOG4105E39 Enoyl-CoA hydratase BF33_831 ENOG4105K64 Glycosyl transferase, family 2 BF33_833 ENOG4108UT6 Transferase hexapeptide repeat containing protein BF33_839 ENOG4105C09 Bile acid BF33_841 ENOG4105RHY Pfam:UPF0157 BF33_846 ENOG4105CIS alcohol dehydrogenase BF33_847 ENOG41082BM Transcriptional regulator, arsr family BF33_851 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BF33_857 ENOG4108A04 Beta-lactamase BF33_858 ENOG4105DPN Oligoendopeptidase f BF33_859 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BF33_860 ENOG4105E5K Alpha-amylase BF33_862 ENOG4105C98 muts2 protein BF33_866 ENOG4107V2S Transcriptional regulator BF33_868 ENOG4107CUJ Protein of unknown function (DUF2690) BF33_87 ENOG4105C28 cystathionine BF33_873 ENOG4107ZY0 Phenazine biosynthesis-like protein BF33_874 ENOG4105NX3 Membrane BF33_875 ENOG4105DQ5 transport system permease protein BF33_876 ENOG4105EHG Permease protein BF33_877 ENOG4108MES Periplasmic binding protein BF33_88 ENOG4105C28 cystathionine BF33_880 ENOG4107R3E Citrate transporter BF33_882 ENOG4108TN2 lmbE family BF33_889 ENOG4105CIS alcohol dehydrogenase BF33_896 ENOG4105H3G oxidoreductase BF33_90 ENOG4105C3R Methionine synthase BF33_907 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BF33_91 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BF33_912 ENOG4105KAF membrAne BF33_921 ENOG4108ZJ4 polysaccharide deacetylase BF33_923 ENOG4105KVH Transcriptional regulator BF33_924 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BF33_926 ENOG4105KNA -acetyltransferase BF33_928 ENOG4105CHR reductase BF33_930 ENOG4105JAB phenazine biosynthesis protein, phzf family BF33_937 ENOG4105KVH Transcriptional regulator BF33_938 ENOG4105KVH Transcriptional regulator BF33_939 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BF33_940 ENOG4105D9R oxidoreductase BF33_941 ENOG4108TZY GntR Family Transcriptional Regulator BF33_948 ENOG4105C44 Serine transporter BF33_955 ENOG4105D4Y metalloprotease BF33_956 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BF33_959 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BF33_961 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BF33_964 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BF33_965 ENOG4105C6Z Gluconate BF33_966 ENOG4105CMG Carbohydrate kinase BF33_967 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BF33_968 ENOG4105XDF Protein of unknown function (DUF1272) BF33_969 ENOG4105DDN Pentapeptide repeat-containing protein BF33_972 ENOG4105C37 (CBS) domain BF33_978 ENOG4105EV4 Multidrug resistance protein mdtH BF33_980 ENOG4105DMQ Methyltransferase BF33_986 ENOG4105C31 Tryptophanyl-tRNA synthetase BF33_988 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BF33_990 ENOG4108UW5 maltose o-acetyltransferase BF33_991 ENOG4106UW1 Major Facilitator superfamily BF33_992 ENOG4105DKQ ROK family BF33_993 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase