locus-tag class description GE376_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GE376_00015 ENOG410848D S4 domain protein YaaA GE376_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GE376_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GE376_00080 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) GE376_00100 ENOG4105ZMH deoxynucleoside kinase GE376_00110 ENOG4105GTG Isochorismatase GE376_00115 ENOG4108Z6B deaminase GE376_00125 ENOG4105C6E dna polymerase iii GE376_00145 ENOG41067KS pro-sigma K processing GE376_00180 ENOG4105CXN decarboxylase GE376_00190 ENOG4105FA2 dna polymerase iii GE376_00195 ENOG4105MA4 psp1 domain protein GE376_00205 ENOG41060K3 Methyltransferase GE376_00215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GE376_00220 ENOG4105KRN Transcriptional regulator, abrb family GE376_00225 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GE376_00230 ENOG4105F8V Hydrolase, tatD family GE376_00235 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) GE376_00245 ENOG4105XFA sporulation peptidase YabG GE376_00250 ENOG4105W42 Veg protein GE376_00265 ENOG4105DFT pur operon repressor GE376_00270 ENOG4105KME endoribonuclease L-psp GE376_00285 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GE376_00290 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GE376_00300 ENOG4108JA2 transcriptioN-repair coupling factor GE376_00305 ENOG4108M14 stage v sporulation protein t GE376_00315 ENOG4108IY2 MazG family GE376_00320 ENOG41082I2 s4 domain protein GE376_00325 ENOG4105VYY sporulation protein yabp GE376_00340 ENOG41060GV RNA binding s1 domain protein GE376_00360 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GE376_00365 ENOG4108UGV hypoxanthine phosphoribosyltransferase GE376_00370 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GE376_00385 ENOG4105C6T cysteine synthase GE376_00390 ENOG4105CRQ synthase (Component I) GE376_00395 ENOG4105DDQ anthranilate synthase GE376_00400 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 GE376_00405 ENOG4105EEI dihydropteroate synthase GE376_00410 ENOG4105KRF dihydroneopterin aldolase GE376_00415 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GE376_00425 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GE376_00515 ENOG4108Z0C Uvrb UvrC protein GE376_00530 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) GE376_00540 ENOG4105CTP PilT protein domain protein GE376_00560 ENOG4105D7W serine acetyltransferase GE376_00575 ENOG4105C2N RNA methyltransferase TrmH family group 3 GE376_00580 ENOG4105M0M Tetracycline resistance protein GE376_00585 ENOG4105QIV RNA polymerase GE376_00600 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GE376_00620 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) GE376_00625 ENOG4107Y49 methyltransferase GE376_00635 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GE376_00640 ENOG4105XPM ribosomal protein GE376_00750 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GE376_00775 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GE376_00785 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GE376_00795 ENOG41067V7 50S ribosomal protein L36 GE376_00820 ENOG4108JJB ABC transporter GE376_00825 ENOG4108JJB ABC transporter GE376_00830 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) GE376_00835 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GE376_00860 ENOG4105D1F ATP-binding protein GE376_00875 ENOG4108NMV polysaccharide deacetylase GE376_00955 ENOG4105C8B TIGR00159 family GE376_00960 ENOG4107U5W ybbr family GE376_00975 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GE376_01000 ENOG4108PSK reductase GE376_01005 ENOG4108UMI ABC transporter, permease GE376_01010 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GE376_01015 ENOG4105D01 (LipO)protein GE376_01020 ENOG4105CB2 alcohol dehydrogenase GE376_01030 ENOG4105IQ5 FAD linked oxidase domain protein GE376_01045 ENOG4105C2C drug resistance transporter, Bcr CflA GE376_01065 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GE376_01070 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GE376_01075 ENOG4105C3U ABC transporter GE376_01080 ENOG4108JQ7 (ABC) transporter GE376_01100 ENOG4108J59 Extracellular solute-binding protein, family 5 GE376_01105 ENOG4108J59 Extracellular solute-binding protein, family 5 GE376_01120 ENOG4106Z1T Nicotinamide Mononucleotide Transporter GE376_01130 ENOG4105E0C molybdate abc transporter GE376_01135 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GE376_01140 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family GE376_01150 ENOG4105EGI Transcriptional regulator GE376_01170 ENOG4105F6E Acyl-transferase GE376_01190 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) GE376_01205 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) GE376_01230 ENOG4105C5H ABC transporter GE376_01245 ENOG4105DEF Extracellular solute-binding protein, family 5 GE376_01255 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GE376_01260 ENOG4105C3U ABC transporter GE376_01265 ENOG4108JQ7 (ABC) transporter GE376_01270 ENOG410667J hydrolase GE376_01295 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase GE376_01300 ENOG4105ERH Fumarylacetoacetate hydrolase GE376_01310 ENOG4105CUB amino acid GE376_01315 ENOG4108SC4 )-transporter GE376_01320 ENOG4105CPF Cell wall formation (By similarity) GE376_01325 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) GE376_01350 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein GE376_01355 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GE376_01365 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) GE376_01470 ENOG4105K8N protein family UPF0079, ATPase GE376_01475 ENOG41072GX Peptidase M22 Glycoprotease GE376_01480 ENOG410801F ribosomal-protein-alanine acetyltransferase GE376_01485 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GE376_01490 ENOG4105C5H ABC transporter GE376_01505 ENOG4108TYN CAAX amino terminal protease family protein GE376_01525 ENOG4105C7N Xanthine uracil vitamin C permease GE376_01535 ENOG4105BZU Histidine kinase GE376_01560 ENOG4107ZXU DSBA oxidoreductase GE376_01625 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) GE376_01655 ENOG4105SX7 Transporter GE376_01685 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GE376_01690 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit GE376_01695 ENOG4105C83 adenylosuccinate lyase GE376_01705 ENOG4105VR9 phosphoribosylformylglycinamidine synthase GE376_01730 ENOG4108V3E phosphoribosylglycinamide formyltransferase GE376_01740 ENOG4105C12 Phosphoribosylglycinamide synthetase GE376_01750 ENOG4105EGI Transcriptional regulator GE376_01775 ENOG4105C4R Atp-dependent dna helicase GE376_01780 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GE376_01800 ENOG4108W2Y isochorismatase GE376_01810 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GE376_01815 ENOG4108UMI ABC transporter, permease GE376_01820 ENOG4105D01 (LipO)protein GE376_01840 ENOG410834F Transcriptional regulator GE376_01845 ENOG4107I77 yiaA/B two helix domain GE376_01865 ENOG4105CBD Diacylglycerol kinase GE376_01875 ENOG4108JPW Aminotransferase GE376_01885 ENOG4105C26 Dehydrogenase GE376_01890 ENOG4105KPY Small multidrug resistance protein GE376_01915 ENOG4105D9N nucleoside GE376_01920 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GE376_01940 ENOG4108W15 Protein of unknown function (DUF1456) GE376_01960 ENOG4105DTQ mandelate racemase muconate lactonizing GE376_01970 ENOG4105DFD Na H antiporter GE376_01990 ENOG4105D3R alkyl hydroperoxide reductase GE376_01995 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) GE376_02000 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) GE376_02005 ENOG4107W7X Aldolase GE376_02010 ENOG4105EHG Permease protein GE376_02015 ENOG4105DQ5 transport system permease protein GE376_02020 ENOG4108V5C ABC transporter GE376_02030 ENOG4105CAY ferredoxin--nadp reductase GE376_02050 ENOG4106UIA GE376_02055 ENOG4106UIA GE376_02070 ENOG4105BZU Histidine kinase GE376_02090 ENOG410756H nucleotidyltransferase GE376_02095 ENOG4105D2S major facilitator superfamily GE376_02110 ENOG4105E5Q amino acid AbC transporter GE376_02115 ENOG4105EAB amino acid AbC transporter GE376_02125 ENOG4105C8Q Methyl-accepting chemotaxis GE376_02140 ENOG4105DBV ornithine carbamoyltransferase GE376_02150 ENOG4105C5B carbamate kinase GE376_02155 ENOG4108W63 CRP FNR family transcriptional regulator GE376_02165 ENOG4105DNP FAD linked oxidase domain protein GE376_02175 ENOG4105CI1 PTS System GE376_02190 ENOG4105C9U ATP-dependent DNA helicase RecQ GE376_02205 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GE376_02225 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GE376_02230 ENOG4105D2X ABC transporter substrate-binding protein GE376_02240 ENOG4105C5H ABC transporter GE376_02275 ENOG41062JF Transcriptional regulator GE376_02290 ENOG4105DEU major facilitator superfamily GE376_02305 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GE376_02320 ENOG4108N0M stress protein GE376_02325 ENOG4106FN3 tellurium resistance protein GE376_02330 ENOG4106FN3 tellurium resistance protein GE376_02335 ENOG4107TS3 membrane protein, TerC GE376_02340 ENOG4108TTB tellurium resistance protein GE376_02355 ENOG41068PA UPF0435 protein GE376_02360 ENOG4105KJF protein tyrosine phosphatase GE376_02370 ENOG4107U9T Pfam:Ribonuclease_BN GE376_02375 ENOG4105C59 p-type ATPase GE376_02380 ENOG4108IPJ Membrane GE376_02400 ENOG4107ZTW SNARE associated Golgi GE376_02415 ENOG410606W general stress protein GE376_02420 ENOG4105UPD Calcium Proton GE376_02455 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GE376_02460 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GE376_02470 ENOG4108JUB Transcriptional regulator GE376_02480 ENOG4108IQI permease GE376_02520 ENOG4108A04 Beta-lactamase GE376_02535 ENOG4107R51 Glycosyl transferase, family 2 GE376_02540 ENOG4107QQG Dehydrogenase GE376_02545 ENOG4105C3I Nad-dependent epimerase dehydratase GE376_02550 ENOG4105CKK Glycosyl transferase, family 2 GE376_02565 ENOG4105F1A Pyruvate formate-lyase GE376_02585 ENOG4105CI2 imidazolone-5-propionate hydrolase GE376_02590 ENOG4105ECP epimerase GE376_02620 ENOG41067AE Membrane-bound metal-dependent hydrolase GE376_02625 ENOG4105CEN a g-specific adenine glycosylase GE376_02630 ENOG4106BXE GE376_02655 ENOG4105BZ1 (ABC) transporter GE376_02660 ENOG4107NBY Membrane GE376_02665 ENOG4105CBC glutamate synthase GE376_02675 ENOG4108IUW ABC transporter GE376_02695 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GE376_02700 ENOG4105G5W regulator Fur family GE376_02820 ENOG4108JQC penicillin-binding protein 1A GE376_02825 ENOG4108R9S DSBA oxidoreductase GE376_02835 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) GE376_02845 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) GE376_02855 ENOG4105CYN Serine protein kinase GE376_02875 ENOG4105C94 Transporter GE376_02890 ENOG4105DZ6 Band 7 protein GE376_02900 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GE376_02905 ENOG4108V9W transcriptional regulatory protein GE376_02910 ENOG4105D4T Citrate transporter GE376_02935 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator GE376_02940 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GE376_02945 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GE376_02950 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component GE376_02955 ENOG4105BZ7 extracellular solute-binding protein family 1 GE376_02960 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) GE376_02965 ENOG4108STX response regulator GE376_02970 ENOG4105US7 Histidine kinase GE376_02995 ENOG4108MRH transcriptional regulatory protein GE376_03005 ENOG4105C6K Malic enzyme GE376_03015 ENOG4108UZ3 Transporter GE376_03020 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GE376_03030 ENOG4105BZU Histidine kinase GE376_03035 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GE376_03040 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GE376_03045 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GE376_03050 ENOG4108JB9 formate dehydrogenase GE376_03070 ENOG4105CUB amino acid GE376_03080 ENOG4105C59 p-type ATPase GE376_03095 ENOG4105DAP Nicotinate phosphoribosyltransferase GE376_03130 ENOG41073R8 VanW family GE376_03135 ENOG4108KGH TRANSCRIPTIONal GE376_03140 ENOG4105D9N nucleoside GE376_03145 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase GE376_03150 ENOG4105C37 (CBS) domain GE376_03155 ENOG4108IJ0 Aspartate ammonia-lyase GE376_03160 ENOG4105DAA L-lactate GE376_03180 ENOG4105DUX Transporter GE376_03185 ENOG4108MES Periplasmic binding protein GE376_03190 ENOG4105DQ5 transport system permease protein GE376_03195 ENOG4108IHU transport system permease protein GE376_03200 ENOG4105E0A ABC, transporter GE376_03215 ENOG4105EXW epimerase dehydratase GE376_03225 ENOG4107T89 von Willebrand factor, type A GE376_03230 ENOG4105GMT ATPase associated with various cellular activities aaa_5 GE376_03235 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GE376_03245 ENOG4105BZU Histidine kinase GE376_03250 ENOG4105D5Q Arginine ornithine antiporter GE376_03255 ENOG4107414 GntR family transcriptional regulator GE376_03260 ENOG4105C5Y PTS System GE376_03265 ENOG4105CG3 alpha amylase, catalytic region GE376_03280 ENOG4105E1K spore germination protein GE376_03290 ENOG4105CRN Aminoglycoside phosphotransferase GE376_03295 ENOG4105BZG amino acid carrier protein GE376_03300 ENOG4105CDA abc transporter atp-binding protein GE376_03305 ENOG4105CT1 (ABC) transporter GE376_03310 ENOG4105EAD ABC transporter GE376_03315 ENOG4105DRP amino acid AbC transporter GE376_03320 ENOG4108IQI permease GE376_03335 ENOG4105GFR rna polymerase sigma factor GE376_03345 ENOG4105D29 Helix-turn-helix type 11 domain protein GE376_03350 ENOG4105NAE bifunctional deaminase-reductase domain protein GE376_03355 ENOG4105BZU Histidine kinase GE376_03370 ENOG4105CHH sulfate transporter GE376_03375 ENOG41068KF Universal stress protein GE376_03385 ENOG4105DEF Extracellular solute-binding protein, family 5 GE376_03395 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GE376_03400 ENOG4108JQ7 (ABC) transporter GE376_03410 ENOG4105CXY transporter GE376_03415 ENOG41067TZ transcriptional regulator, MarR family GE376_03420 ENOG4105C0R drug resistance transporter emrb qaca subfamily GE376_03425 ENOG4105ETE Transcriptional regulator (LacI family GE376_03430 ENOG4108RVA ribokinase GE376_03440 ENOG4105C2J ABC transporter GE376_03445 ENOG4105CNN ABC, transporter GE376_03450 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GE376_03455 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GE376_03490 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) GE376_03520 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GE376_03525 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer GE376_03530 ENOG41069ER domain protein GE376_03535 ENOG4105VZ8 Transcriptional regulator GE376_03540 ENOG4107D63 GE376_03555 ENOG4105DUX Transporter GE376_03575 ENOG4105C85 amino acid GE376_03580 ENOG4105C7N Xanthine uracil vitamin C permease GE376_03595 ENOG4105MA6 gCN5-related N-acetyltransferase GE376_03615 ENOG4105CCU oxidase (Subunit III) GE376_03620 ENOG4105BZ9 Cytochrome C oxidase, subunit I GE376_03625 ENOG4105E2S oxidase) subunit II GE376_03645 ENOG4106CAD Protein of unknown function (DUF3311) GE376_03650 ENOG4105E1V na solute symporter GE376_03665 ENOG4108NHD germination protein GE376_03670 ENOG4105CE1 Ferrous iron transport protein b GE376_03675 ENOG4105CE1 Ferrous iron transport protein b GE376_03680 ENOG4105CE1 Ferrous iron transport protein b GE376_03685 ENOG4105CVA phosphate GE376_03690 ENOG4105C8U phosphate abc transporter GE376_03695 ENOG4105E2Z phosphate ABC transporter (Permease GE376_03825 ENOG41080XQ Signal transduction protein with cbs domains GE376_03845 ENOG4105ETU transcriptional activator (TenA GE376_03855 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GE376_03865 ENOG4108VEU Thiamine monophosphate synthase GE376_03870 ENOG41080HI glycine oxidase GE376_03885 ENOG4105D06 uba thif-type nad fad binding protein GE376_03890 ENOG4105DWF phosphomethylpyrimidine kinase GE376_03925 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) GE376_03940 ENOG4108INS Transcriptional regulator GE376_03955 ENOG4105C7N Xanthine uracil vitamin C permease GE376_03965 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GE376_03980 ENOG4105K63 Thioredoxin GE376_04000 ENOG4108B31 Spore germination protein GE376_04020 ENOG4107Y03 Nitroreductase GE376_04025 ENOG4105ED1 spovr family GE376_04035 ENOG4105J4Q Transcriptional regulator GE376_04050 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase GE376_04055 ENOG4105XTG Pfam:DUF156 GE376_04060 ENOG4105VFE sira family GE376_04065 ENOG4107TPS domain protein GE376_04070 ENOG4105VFE sira family GE376_04075 ENOG41085GJ domain protein GE376_04085 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase GE376_04090 ENOG41087NI Sulfite exporter TauE/SafE GE376_04100 ENOG4108KGH TRANSCRIPTIONal GE376_04130 ENOG4105EMD TRANSCRIPTIONal GE376_04135 ENOG4105VCP PTS System GE376_04140 ENOG4105VZJ PTS System GE376_04160 ENOG41069ER domain protein GE376_04165 ENOG4107RBB ABC transporter, permease GE376_04170 ENOG4105C19 ABC transporter GE376_04200 ENOG4105WEF catalase GE376_04235 ENOG4107T5V SNARE associated Golgi GE376_04265 ENOG4105CUB amino acid GE376_04270 ENOG4107RWR Sodium hydrogen exchanger GE376_04280 ENOG4106KNT transcriptional regulator GE376_04320 ENOG4108YXU transcriptional regulator AsnC family GE376_04325 ENOG4105CH7 arginosuccinase GE376_04330 ENOG4105UBK short-chain dehydrogenase reductase GE376_04340 ENOG4105KPY Small multidrug resistance protein GE376_04345 ENOG4105KPY Small multidrug resistance protein GE376_04375 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) GE376_04380 ENOG4105E5W Transporter GE376_04390 ENOG4107RKG DJ-1/PfpI family GE376_04395 ENOG4105CH6 catalase GE376_04405 ENOG4105D5Q Arginine ornithine antiporter GE376_04410 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) GE376_04420 ENOG4105C26 Dehydrogenase GE376_04435 ENOG4105BZ1 (ABC) transporter GE376_04440 ENOG4105BZ1 (ABC) transporter GE376_04455 ENOG4105DRP amino acid AbC transporter GE376_04460 ENOG4105CDA abc transporter atp-binding protein GE376_04475 ENOG410839P GE376_04485 ENOG4108UH6 UPF0754 membrane protein GE376_04515 ENOG4107FQX Alpha-acetolactate decarboxylase GE376_04540 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase GE376_04545 ENOG4105D4P Coproporphyrinogen iii oxidase GE376_04550 ENOG4105CEY Amp-dependent synthetase and ligase GE376_04565 ENOG4105CHH sulfate transporter GE376_04595 ENOG4105CGU Enoyl-CoA hydratase GE376_04615 ENOG4105DER m42 family GE376_04635 ENOG4105CTU Proline racemase GE376_04640 ENOG4105CIF Ornithine Cyclodeaminase GE376_04660 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GE376_04665 ENOG4105C3U ABC transporter GE376_04670 ENOG4108JQ7 (ABC) transporter GE376_04730 ENOG4105CSH Transporter GE376_04740 ENOG4108MRH transcriptional regulatory protein GE376_04750 ENOG4105M6F mutator MutT protein GE376_04765 ENOG4105CDU Replicative dna helicase GE376_04800 ENOG4105C0R drug resistance transporter emrb qaca subfamily GE376_04815 ENOG4105D9U N-acetyltransferase GE376_04840 ENOG4105F6J Alpha beta hydrolase fold GE376_04880 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase GE376_04895 ENOG4105F27 Major Facilitator GE376_04900 ENOG4105WAB arsR family transcriptional regulator GE376_04915 ENOG4105CMT Dihydroxyacetone kinase GE376_04930 ENOG4105CMT Dihydroxyacetone kinase GE376_05010 ENOG4108WC5 Alpha Beta Hydrolase Fold protein GE376_05060 ENOG4105WN5 stage II sporulation protein GE376_05070 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GE376_05080 ENOG4108MJI response regulator GE376_05085 ENOG4105BZU Histidine kinase GE376_05090 ENOG4105BZU Histidine kinase GE376_05125 ENOG4107QHE Choloylglycine hydrolase GE376_05145 ENOG4107VRP DNA repair exonuclease GE376_05150 ENOG4106D4I domain protein GE376_05165 ENOG410829K Lysine exporter protein (Lyse ygga) GE376_05190 ENOG4108MUZ hydrolase GE376_05215 ENOG4105F0F Oxalate decarboxylase GE376_05220 ENOG41067QW Transcriptional regulator GE376_05225 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator GE376_05240 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GE376_05255 ENOG4105EMN RNA polymerase sigma factor GE376_05275 ENOG4105EYF MMPL domain protein GE376_05280 ENOG4105EEM helicase GE376_05290 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GE376_05320 ENOG4105K59 histidine triad (HIT) protein GE376_05395 ENOG410905X membrane-flanked domain protein GE376_05400 ENOG4105CKV Membrane GE376_05450 ENOG410905X membrane-flanked domain protein GE376_05455 ENOG4105CKV Membrane GE376_05460 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation GE376_05465 ENOG4105BZ4 penicillin-binding protein GE376_05475 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GE376_05480 ENOG4105C1Q protoporphyrinogen oxidase GE376_05505 ENOG4105NA0 Transcriptional regulator GE376_05520 ENOG4105ECB domain protein GE376_05550 ENOG4106AXD GE376_05555 ENOG4108RQ5 Beta-lactamase domain-containing protein GE376_05560 ENOG4105DF9 Lipoate-protein, ligase GE376_05570 ENOG4105CEY Amp-dependent synthetase and ligase GE376_05580 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein GE376_05585 ENOG4108I5D sulfate abc transporter GE376_05590 ENOG4105ECW sulfate abc transporter GE376_05595 ENOG4108IJ6 ABC transporter GE376_05600 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) GE376_05610 ENOG4107RN3 metallophosphoesterase GE376_05620 ENOG4107TVP HD domain protein GE376_05630 ENOG4108AEY RNA polymerase sigma factor GE376_05635 ENOG41086D8 Transcriptional regulator GE376_05650 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GE376_05670 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 GE376_05675 ENOG4105C8Q Methyl-accepting chemotaxis GE376_05685 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) GE376_05695 ENOG4107QP3 malate synthase g GE376_05715 ENOG4105VEQ Cold shock protein GE376_05750 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation GE376_05755 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GE376_05795 ENOG4105ERH Fumarylacetoacetate hydrolase GE376_05805 ENOG4105C8Y Acetylornithine aminotransferase GE376_05820 ENOG4105CAQ asparagine synthetase GE376_05825 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GE376_05830 ENOG4105CH6 catalase GE376_05835 ENOG4105BZU Histidine kinase GE376_05860 ENOG4105QNR S1 RNA binding domain protein GE376_05865 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GE376_05875 ENOG4107AYK membrAne GE376_05880 ENOG41073B9 GE376_05890 ENOG4108KP7 hydrolase GE376_05900 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GE376_05925 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GE376_05930 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GE376_05945 ENOG4105C31 Tryptophanyl-tRNA synthetase GE376_05965 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GE376_05970 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GE376_05980 ENOG4108JQ7 (ABC) transporter GE376_05985 ENOG4105UQX Mate efflux family protein GE376_06010 ENOG4108ZCF integral membrane protein GE376_06020 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GE376_06030 ENOG4105DPN Oligoendopeptidase f GE376_06040 ENOG4108Z18 K06886 hemoglobin GE376_06045 ENOG4105MIX Adenylate cyclase GE376_06050 ENOG4106EFP UPF0738 protein GE376_06060 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GE376_06065 ENOG4105EMS pseudouridine synthase GE376_06085 ENOG4105K64 Glycosyl transferase, family 2 GE376_06105 ENOG4107TVC Glycosyl transferase, family 2 GE376_06125 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) GE376_06130 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase GE376_06140 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase GE376_06215 ENOG4105CK7 Sodium proline symporter GE376_06220 ENOG4105CRQ synthase (Component I) GE376_06225 ENOG4105DDQ anthranilate synthase GE376_06235 ENOG4105DK0 Indole-3-glycerol phosphate synthase GE376_06240 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase GE376_06245 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GE376_06280 ENOG4105T65 Membrane-associated protein GE376_06305 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GE376_06325 ENOG4105C7S Dehydrogenase GE376_06335 ENOG4105VZ8 Transcriptional regulator GE376_06400 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) GE376_06410 ENOG4105DZ1 carboxypeptidase GE376_06415 ENOG4105VFR signal peptidase GE376_06450 ENOG4105C26 Dehydrogenase GE376_06455 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GE376_06460 ENOG4105F38 ABC transporter, permease GE376_06465 ENOG4105D38 putrescine abc transporter GE376_06470 ENOG4107RUE extracellular solute-binding protein family 1 GE376_06480 ENOG4105EYF MMPL domain protein GE376_06490 ENOG4108YBP pseudouridine synthase GE376_06500 ENOG4105K4I Scp-like extracellular GE376_06505 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GE376_06510 ENOG4105CQB FAD linked oxidase domain protein GE376_06525 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GE376_06530 ENOG4105BZU Histidine kinase GE376_06535 ENOG4105JXH GntR family transcriptional regulator GE376_06555 ENOG4106A3R peptidase GE376_06565 ENOG4108QTI )-transporter GE376_06570 ENOG4107TS3 membrane protein, TerC GE376_06575 ENOG4105CZN Potassium uptake protein GE376_06580 ENOG410681C small acid-soluble spore protein GE376_06585 ENOG4108Z7G MaoC domain protein dehydratase GE376_06605 ENOG4105CHR reductase GE376_06635 ENOG4105C4Y ABC transporter GE376_06640 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GE376_06645 ENOG4107RCV ABC transporter, permease GE376_06665 ENOG4105E98 transcriptional regulator DeoR family GE376_06675 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) GE376_06685 ENOG4105PXI polysaccharide deacetylase GE376_06695 ENOG4105BZU Histidine kinase GE376_06700 ENOG41090MY MarR family Transcriptional regulator GE376_06710 ENOG4106DF1 GE376_06715 ENOG4105BZU Histidine kinase GE376_06720 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) GE376_06725 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase GE376_06730 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) GE376_06770 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) GE376_06775 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GE376_06780 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GE376_06785 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family GE376_06790 ENOG4105CZV ABC transporter GE376_06800 ENOG4105CJ1 ABC, transporter GE376_06840 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GE376_06845 ENOG4105EA8 2-Nitropropane dioxygenase GE376_06850 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD GE376_06860 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein GE376_06880 ENOG4105NQC Flavodoxin GE376_06910 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GE376_06940 ENOG4105CZN Potassium uptake protein GE376_06945 ENOG41063Y9 GE376_06950 ENOG4105KBJ sporulation protein ytfj GE376_06970 ENOG4105CM2 brancheD-chain amino acid aminotransferase GE376_06975 ENOG4105C7K acetolactate synthase GE376_06980 ENOG4108ZP8 Acetolactate synthase small subunit GE376_06985 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GE376_07000 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GE376_07020 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GE376_07025 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GE376_07030 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GE376_07055 ENOG4107RVV histidinol phosphate phosphatase, hisj family GE376_07070 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase GE376_07075 ENOG4105E0M Sulfatase GE376_07085 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GE376_07105 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) GE376_07110 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) GE376_07120 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GE376_07125 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein GE376_07130 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein GE376_07135 ENOG4105C8J )-transporter GE376_07155 ENOG4105DFD Na H antiporter GE376_07175 ENOG4105ENE Histidine kinase GE376_07180 ENOG4105WH1 Two component transcriptional regulator luxr family GE376_07200 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GE376_07225 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GE376_07245 ENOG4105CJ3 phosphate transporter GE376_07250 ENOG4107GRR phosphate transport regulator GE376_07255 ENOG4105BZ4 penicillin-binding protein GE376_07270 ENOG4105BZU Histidine kinase GE376_07275 ENOG4105I3N Conserved Protein GE376_07290 ENOG4105BZU Histidine kinase GE376_07320 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GE376_07325 ENOG4105DZ1 carboxypeptidase GE376_07330 ENOG4108JIC nucleoside recognition domain protein GE376_07340 ENOG4105FE9 pseudouridine synthase GE376_07345 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GE376_07350 ENOG4107TWT Cytochrome c biogenesis protein GE376_07355 ENOG4105CRE cytochrome C GE376_07360 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GE376_07365 ENOG4105BZU Histidine kinase GE376_07370 ENOG4108WBT adenosyltransferase GE376_07385 ENOG4108SAX Membrane GE376_07400 ENOG4105C9U ATP-dependent DNA helicase RecQ GE376_07405 ENOG4105I7S Abortive infection protein GE376_07415 ENOG4107RGJ metallophosphoesterase GE376_07420 ENOG4108XDN Transcriptional regulator GE376_07425 ENOG4108S6Z Negative regulator of genetic competence GE376_07450 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase GE376_07455 ENOG4107RB3 L-asparaginase GE376_07490 ENOG4105S2F GE376_07495 ENOG41065D1 GE376_07525 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) GE376_07540 ENOG4105XXQ heptaprenyl diphosphate synthase component I GE376_07550 ENOG4105EAH synthase GE376_07555 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GE376_07560 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GE376_07575 ENOG41068YB TPR repeat-containing protein GE376_07590 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) GE376_07595 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GE376_07630 ENOG4108JYZ YitT family GE376_07640 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase GE376_07655 ENOG4105FJR Lmbe family GE376_07660 ENOG4105CPK Glycosyl transferase (Group 1 GE376_07680 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GE376_07695 ENOG4105DVT helicase GE376_07700 ENOG4105YAC GE376_07720 ENOG4105CSM endonuclease III GE376_07730 ENOG4105BZ4 penicillin-binding protein GE376_07770 ENOG4106F55 Protein of unknown function (DUF1273) GE376_07785 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) GE376_07795 ENOG4105DVT helicase GE376_07800 ENOG4105CTD carboxy-peptidase GE376_07810 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GE376_07820 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) GE376_07825 ENOG4105C2W permease GE376_07830 ENOG4105DHF Membrane GE376_07835 ENOG410890F Dynamin family GE376_07845 ENOG4108W0I acetyltransferase GE376_07855 ENOG4105KHC sulfurtransferase GE376_07915 ENOG4105HTX biosynthesis protein GE376_07945 ENOG4105CPK Glycosyl transferase (Group 1 GE376_07960 ENOG4108SZE gCN5-related N-acetyltransferase GE376_07980 ENOG41081VK Ribonuclease GE376_08045 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GE376_08055 ENOG4107RWR Sodium hydrogen exchanger GE376_08060 ENOG4108Z5V transcriptional regulator, merr family GE376_08070 ENOG4105H67 Protein of unknown function (DUF421) GE376_08075 ENOG41080C8 DUF218 domain GE376_08135 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GE376_08145 ENOG4107R0U MotA TolQ exbB proton channel GE376_08150 ENOG4105ER2 Ompa motb domain protein GE376_08155 ENOG4107YTP response regulator receiver protein GE376_08160 ENOG4105CBS Chea signal transduction histidine kinase GE376_08165 ENOG4105DD5 Flagellar motor switch protein GE376_08180 ENOG4105BZU Histidine kinase GE376_08200 ENOG4105E1Q flagellar hook-associated protein GE376_08205 ENOG4105DTJ flagellar hook-associated protein GE376_08225 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GE376_08230 ENOG4108ZC9 flagellar basal-body rod protein flgc GE376_08235 ENOG41075Z6 flagellar hook-basal body complex protein fliE GE376_08240 ENOG4107U2N Flagellar M-ring protein GE376_08245 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GE376_08275 ENOG4105BZE flagellar hook protein, FlgE GE376_08290 ENOG4107R88 Chemotaxis protein (CheV) GE376_08300 ENOG4105I03 Flagellin GE376_08305 ENOG4105I03 Flagellin GE376_08310 ENOG4105E4C Lytic transglycosylase catalytic GE376_08320 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GE376_08325 ENOG4105DD5 Flagellar motor switch protein GE376_08335 ENOG4105CN7 Flagellar biosynthetic protein FliP GE376_08340 ENOG4105VS8 Flagellar biosynthetic protein fliq GE376_08350 ENOG4105D00 flagellar biosynthetic protein flhB GE376_08355 ENOG4105D7B Flagellar biosynthesis protein flha GE376_08360 ENOG4105FZW flagellar biosynthesis regulator FlhF GE376_08365 ENOG4105KTQ flagellar basal-body rod protein GE376_08375 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GE376_08410 ENOG4105KAC Antibiotic biosynthesis monooxygenase GE376_08415 ENOG4107QZ7 Cellulose synthase catalytic subunit GE376_08440 ENOG4105DUM transcriptional regulator, lysR family GE376_08445 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GE376_08455 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component GE376_08460 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GE376_08505 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GE376_08525 ENOG4105CAQ asparagine synthetase GE376_08545 ENOG4105PGM cation diffusion facilitator family transporter GE376_08555 ENOG4105DRR Transcriptional regulator, GntR family GE376_08560 ENOG4108UZ3 Transporter GE376_08570 ENOG4105CKI cobalamin synthesis protein GE376_08580 ENOG4108PJD permease GE376_08595 ENOG4105DFD Na H antiporter GE376_08600 ENOG4105VUF Transcriptional regulator GE376_08610 ENOG4105C9Q fumarate hydratase class II GE376_08625 ENOG4107QJQ Mate efflux family protein GE376_08630 ENOG4105EC3 peptidase S51, dipeptidase E GE376_08650 ENOG4107QIV Cytochrome c biogenesis protein GE376_08655 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GE376_08680 ENOG4105BZC d-serine deaminase GE376_08685 ENOG4106BRA Membrane GE376_08725 ENOG4105CJ1 ABC, transporter GE376_08745 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GE376_08755 ENOG4108IJ0 Aspartate ammonia-lyase GE376_08760 ENOG4105C6K Malic enzyme GE376_08820 ENOG4105FVX GE376_08835 ENOG4105CSR polyphosphate kinase 2 GE376_08840 ENOG4105U3E Transcriptional regulator GE376_08850 ENOG4105DXI Major Facilitator superfamily GE376_08865 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GE376_08870 ENOG4105EU0 Major facilitator Superfamily GE376_08875 ENOG4105C6T cysteine synthase GE376_08895 ENOG4105C8J )-transporter GE376_08905 ENOG4105X5K response regulator receiver protein GE376_08910 ENOG4105H67 Protein of unknown function (DUF421) GE376_08930 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GE376_08935 ENOG4105CHR reductase GE376_08940 ENOG4105CM2 brancheD-chain amino acid aminotransferase GE376_08945 ENOG4105C7K acetolactate synthase GE376_08955 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GE376_08965 ENOG4105C7B Threonine dehydratase GE376_08990 ENOG4105C6X Major Facilitator GE376_08995 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b GE376_09005 ENOG4105DY9 regulatoR GE376_09010 ENOG4105CYC Transferase GE376_09030 ENOG4105EQ0 Major Facilitator superfamily GE376_09035 ENOG4108IND Tetr family transcriptional regulator GE376_09085 ENOG41068WN GE376_09090 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GE376_09110 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) GE376_09125 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GE376_09130 ENOG4105C0X amino acid GE376_09170 ENOG410849A acetyltransferase, (GNAT) family GE376_09195 ENOG4107RHR regulatoR GE376_09205 ENOG4105D9N nucleoside GE376_09210 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) GE376_09240 ENOG410811B TRANSCRIPTIONal GE376_09255 ENOG4107RAQ aminopeptidase GE376_09265 ENOG4107R16 Multicopper oxidase GE376_09310 ENOG4108T5E Copper resistance protein GE376_09315 ENOG4105KTB nuclear export factor GLE1 GE376_09320 ENOG4107RT3 EamA-like transporter family GE376_09325 ENOG4105GZI Transcriptional regulator GE376_09330 ENOG4108Z40 Transcriptional regulator GE376_09335 ENOG4107ZXU DSBA oxidoreductase GE376_09340 ENOG4108TVJ Nitroreductase GE376_09345 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GE376_09350 ENOG4106F5Q Membrane GE376_09355 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GE376_09370 ENOG4105CKI cobalamin synthesis protein GE376_09380 ENOG4105C0Z ABC transporter GE376_09385 ENOG4108IV0 ABC, transporter GE376_09390 ENOG4105C32 Amino acid ABC transporter (Permease) GE376_09400 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family GE376_09410 ENOG4105MDS 4-oxalocrotonate tautomerase GE376_09430 ENOG4105C4M (Ubiquinol oxidase) subunit I GE376_09435 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GE376_09440 ENOG4108JJ9 ABC, transporter GE376_09445 ENOG4108JJ8 (ABC) transporter GE376_09455 ENOG4105K64 Glycosyl transferase, family 2 GE376_09465 ENOG4108UT6 Transferase hexapeptide repeat containing protein GE376_09520 ENOG4105BZ1 (ABC) transporter GE376_09525 ENOG4105EFI regulatoR GE376_09530 ENOG4105BZU Histidine kinase GE376_09550 ENOG41075D4 Aminoglycoside 6-adenylyltransferase GE376_09555 ENOG4108ZJ4 polysaccharide deacetylase GE376_09575 ENOG4105D6E homoserine dehydrogenase GE376_09585 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) GE376_09600 ENOG4108KGH TRANSCRIPTIONal GE376_09610 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GE376_09615 ENOG4105BZU Histidine kinase GE376_09620 ENOG4107VMI polysaccharide deacetylase GE376_09630 ENOG4105KT7 mgtC SapB transporter GE376_09635 ENOG4105VRR gCN5-related N-acetyltransferase GE376_09645 ENOG4105DUU IucA IucC family protein GE376_09650 ENOG4105CEY Amp-dependent synthetase and ligase GE376_09665 ENOG4108WBH protein TIM barrel GE376_09670 ENOG4105YWU small acid-soluble spore protein GE376_09680 ENOG4108ZUB Lysine exporter protein (Lyse ygga) GE376_09685 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GE376_09735 ENOG4105KRN Transcriptional regulator, abrb family GE376_09745 ENOG4105YVS arsR family transcriptional regulator GE376_09750 ENOG4105CPC Aldo Keto reductase GE376_09755 ENOG4107XZQ multidrug resistance protein GE376_09780 ENOG4105C8Q Methyl-accepting chemotaxis GE376_09795 ENOG4108K88 Membrane GE376_09800 ENOG4108WPJ Ferritin-like domain GE376_09815 ENOG4105DEN Luciferase family GE376_09830 ENOG4105VMI -acetyltransferase GE376_09835 ENOG4107QM2 Aldo Keto reductase GE376_09840 ENOG4105CKI cobalamin synthesis protein GE376_09850 ENOG4105DSE periplasmic solute binding protein GE376_09855 ENOG4105K4T epimerase GE376_09865 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GE376_09910 ENOG4107T5V SNARE associated Golgi GE376_09925 ENOG4108PJD permease GE376_09935 ENOG4108S4H thioesterase Superfamily protein GE376_09945 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GE376_09965 ENOG4105SXS Protein of unknown function (DUF456) GE376_09970 ENOG4105C37 (CBS) domain GE376_10000 ENOG4108Z7R Chaperone CsaA GE376_10020 ENOG4108ZRV stage ii sporulation protein p GE376_10035 ENOG4108VXD carboxy-peptidase GE376_10065 ENOG4108ZRV stage ii sporulation protein p GE376_10075 ENOG4108X4Q Hydrolase GE376_10080 ENOG41082F9 transcriptional regulator GE376_10085 ENOG4105D94 Major Facilitator Superfamily GE376_10095 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GE376_10100 ENOG4107RBS Methyltransferase GE376_10115 ENOG41087PP glycosyltransferase MGT family GE376_10120 ENOG4108JYZ YitT family GE376_10125 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GE376_10155 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GE376_10205 ENOG4105KBJ sporulation protein ytfj GE376_10230 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GE376_10250 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) GE376_10255 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily GE376_10265 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GE376_10270 ENOG4105EMN RNA polymerase sigma factor GE376_10285 ENOG4105CNW domain protein GE376_10295 ENOG4108V06 Glutathione peroxidase GE376_10310 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GE376_10320 ENOG4108IUE nitrate reductase beta subunit GE376_10325 ENOG4105R3A Nitrate reductase GE376_10335 ENOG4107V6Q Cyclic nucleotide-binding domain GE376_10340 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GE376_10345 ENOG4105D06 uba thif-type nad fad binding protein GE376_10350 ENOG4105CVM Molybdenum cofactor synthesis domain protein GE376_10355 ENOG4108ZAF Molybdopterin GE376_10380 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein GE376_10385 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein GE376_10390 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GE376_10395 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit GE376_10400 ENOG4108IFG nitrite reductase, (NAD(P)H) GE376_10405 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) GE376_10440 ENOG4105MCT stage V sporulation protein S GE376_10480 ENOG4107T65 Integrase GE376_10485 ENOG410635T phage-like element pbsx protein GE376_10515 ENOG4108IMY Transcriptional regulator GE376_10640 ENOG4108N0N Phage Terminase Large Subunit GE376_10780 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis GE376_10815 ENOG4105C5H ABC transporter GE376_10830 ENOG4108UUM single-stranded DNA-binding protein GE376_10855 ENOG4107YX5 Pfam:DUF548 GE376_10860 ENOG4105C75 arginyL-tRNA synthetase GE376_10875 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GE376_10900 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) GE376_10905 ENOG4105C5S asparaginyl-tRNA synthetase GE376_10925 ENOG4105EC2 ftsk spoIIIe GE376_11000 ENOG4105C8J )-transporter GE376_11020 ENOG4107XGZ Hydrolase GE376_11025 ENOG4105CY2 Citrate transporter GE376_11045 ENOG4105KD7 acetyltransferase GE376_11055 ENOG4105VMP Transcriptional regulator GE376_11060 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase GE376_11085 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 GE376_11100 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) GE376_11115 ENOG4107RVG penicillin-binding protein GE376_11125 ENOG4105E9Q Acyl-transferase GE376_11130 ENOG4108UT2 hemolysin iii GE376_11140 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GE376_11150 ENOG4108RCR degv family GE376_11160 ENOG4108KF3 Electron transport protein SCO1 SenC GE376_11165 ENOG4107Y70 Heat shock protein GE376_11170 ENOG4105CAQ asparagine synthetase GE376_11185 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GE376_11190 ENOG4108MES Periplasmic binding protein GE376_11195 ENOG4105F0I Aminotransferase GE376_11225 ENOG4105D8X mechanosensitive ion channel GE376_11230 ENOG4105BZU Histidine kinase GE376_11235 ENOG4105WH1 Two component transcriptional regulator luxr family GE376_11240 ENOG4106KNT transcriptional regulator GE376_11245 ENOG4107ZY0 Phenazine biosynthesis-like protein GE376_11265 ENOG4105CMG Carbohydrate kinase GE376_11270 ENOG4105C6Z Gluconate GE376_11280 ENOG4108YV3 Protein of unknown function (DUF2711) GE376_11310 ENOG4108IJ8 ABC transporter GE376_11315 ENOG4105E90 ABC transporter GE376_11350 ENOG4105C37 (CBS) domain GE376_11375 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GE376_11390 ENOG4107S4Y M20 DapE family protein YgeY GE376_11395 ENOG4108TSC N-acetyltransferase GE376_11400 ENOG4108JUB Transcriptional regulator GE376_11405 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein GE376_11445 ENOG4108N23 SpoOM-related protein GE376_11450 ENOG410841Q phosphoesterase PA-phosphatase related protein GE376_11460 ENOG4105SZ6 Thioredoxin GE376_11465 ENOG4105KNA -acetyltransferase GE376_11505 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GE376_11555 ENOG4105BZ4 penicillin-binding protein GE376_11565 ENOG4105CZM Major Facilitator GE376_11570 ENOG4105W8X HesB YadR YfhF-family protein GE376_11580 ENOG4105DXD 2-methylcitrate dehydratase GE376_11585 ENOG4105CR4 methylisocitrate lyase GE376_11590 ENOG4105C1G acyl-Coa dehydrogenase GE376_11595 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GE376_11605 ENOG4105N14 lysine exporter protein LysE YggA GE376_11610 ENOG4105E39 Enoyl-CoA hydratase GE376_11625 ENOG4107RFY SbcCD D subunit GE376_11630 ENOG4105EYH Exonuclease GE376_11660 ENOG4105FCD Major Facilitator GE376_11665 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase GE376_11670 ENOG4105E4F Isochorismate synthase GE376_11675 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase GE376_11680 ENOG4105WQI isochorismatase GE376_11685 ENOG4105CEY Amp-dependent synthetase and ligase GE376_11690 ENOG4105WQT MbtH domain protein GE376_11695 ENOG4105C0R drug resistance transporter emrb qaca subfamily GE376_11710 ENOG4105K70 DNA-binding protein GE376_11730 ENOG4105BZG amino acid carrier protein GE376_11750 ENOG4105FE9 pseudouridine synthase GE376_11755 ENOG4105C22 threonyL-tRNA synthetase GE376_11760 ENOG4105C19 ABC transporter GE376_11810 ENOG41081I9 integral membrane protein GE376_11820 ENOG4108Y4K DNA-binding transcriptional activator GE376_11835 ENOG4107MII Sugar-specific transcriptional regulator TrmB GE376_11845 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GE376_11855 ENOG4105EYF MMPL domain protein GE376_11880 ENOG4105WCN acetyltransferase GE376_11905 ENOG4105C1Q protoporphyrinogen oxidase GE376_11920 ENOG41068WN GE376_11950 ENOG4107V2S Transcriptional regulator GE376_11955 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GE376_11975 ENOG4105DND Transcriptional regulator GE376_11980 ENOG4108RPX mosc domain containing protein GE376_11995 ENOG4105BZ1 (ABC) transporter GE376_12000 ENOG4105BZ1 (ABC) transporter GE376_12085 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase GE376_12115 ENOG4108JCI Transcriptional regulator GE376_12150 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) GE376_12155 ENOG4108KPJ rna polymerase sigma factor GE376_12175 ENOG4105F32 YngK protein GE376_12195 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) GE376_12200 ENOG4105RD7 BadF BadG BcrA BcrD GE376_12205 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GE376_12215 ENOG4105C7B Threonine dehydratase GE376_12220 ENOG4108INS Transcriptional regulator GE376_12235 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GE376_12245 ENOG4105C1J atp-dependent rna helicase GE376_12255 ENOG4108RZE Tetr family transcriptional regulator GE376_12275 ENOG41088CC tellurite resistance protein tehB GE376_12290 ENOG4107RA9 decarboxylase GE376_12295 ENOG4105K56 Transcriptional regulator GE376_12300 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GE376_12325 ENOG4105CIN aminoacyl-histidine dipeptidase GE376_12360 ENOG4105KRN Transcriptional regulator, abrb family GE376_12370 ENOG4105EJ9 Membrane GE376_12375 ENOG4105EQK -acetyltransferase GE376_12415 ENOG4105W8Z 4'-phosphopantetheinyl transferase GE376_12465 ENOG4108Q8B Spore germination protein GE376_12470 ENOG4108NHD germination protein GE376_12475 ENOG4105II7 pyrroline-5-carboxylate reductase GE376_12480 ENOG4105CUB amino acid GE376_12485 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GE376_12505 ENOG41075H3 AraC family transcriptional regulator GE376_12530 ENOG4105BZU Histidine kinase GE376_12625 ENOG4105EJQ L-serine dehydratase GE376_12630 ENOG4105C44 Serine transporter GE376_12645 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer GE376_12665 ENOG41067SE Tetr family transcriptional regulator GE376_12695 ENOG4105VPS UPF0291 protein GE376_12700 ENOG4105DEN Luciferase family GE376_12705 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) GE376_12725 ENOG4108VJ1 Transcriptional regulator (CarD family GE376_12760 ENOG410829K Lysine exporter protein (Lyse ygga) GE376_12770 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GE376_12775 ENOG4105FQP Beta-lactamase GE376_12795 ENOG4107RVG penicillin-binding protein GE376_12810 ENOG4107RF6 penicillin-binding protein GE376_12815 ENOG4107RF6 penicillin-binding protein GE376_12825 ENOG4105DIN metallophosphoesterase GE376_12835 ENOG4105CJ1 ABC, transporter GE376_12845 ENOG4107Z3H Transcriptional regulator, TetR family GE376_12860 ENOG4105C1G acyl-Coa dehydrogenase GE376_12865 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GE376_12870 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit GE376_12875 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GE376_12880 ENOG4105E39 Enoyl-CoA hydratase GE376_12885 ENOG4107QX3 carboxylase GE376_12890 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GE376_12925 ENOG4105DZ1 carboxypeptidase GE376_12940 ENOG4105T9C HD domain GE376_12970 ENOG41075H3 AraC family transcriptional regulator GE376_13000 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GE376_13010 ENOG4105CHR reductase GE376_13015 ENOG4105KVH Transcriptional regulator GE376_13070 ENOG4105EFA 4-hydroxyphenylacetate GE376_13085 ENOG4105CPQ Dehydrogenase GE376_13095 ENOG410900G Protein of unknown function (DUF421) GE376_13105 ENOG4108V4B ThiJ pfpI GE376_13115 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein GE376_13125 ENOG4105DK7 lysyl-tRNA synthetase GE376_13200 ENOG4105D6E homoserine dehydrogenase GE376_13210 ENOG4105CPF Cell wall formation (By similarity) GE376_13215 ENOG4105ETU transcriptional activator (TenA GE376_13240 ENOG4105VTR Integrase GE376_13275 ENOG4105KRN Transcriptional regulator, abrb family GE376_13310 ENOG4105KNA -acetyltransferase GE376_13380 ENOG4105CAR Terminase, large subunit GE376_13390 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GE376_13475 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase GE376_13570 ENOG410667J hydrolase GE376_13575 ENOG4105BZU Histidine kinase GE376_13580 ENOG4107RF6 penicillin-binding protein GE376_13605 ENOG4108JJB ABC transporter GE376_13620 ENOG4108HGU Histidine kinase GE376_13625 ENOG4105VTR Integrase GE376_13695 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GE376_13700 ENOG4105GR3 Histidine kinase GE376_13705 ENOG4105CB2 alcohol dehydrogenase GE376_13710 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GE376_13715 ENOG4105CJN penicillin-binding protein GE376_13765 ENOG4107TXC Transcriptional regulator GE376_13770 ENOG4107Y80 Major Facilitator superfamily GE376_13785 ENOG4107VXM glycerophosphoryl diester phosphodiesterase GE376_13810 ENOG4107Y9U Membrane GE376_13850 ENOG4105FCD Major Facilitator GE376_13860 ENOG4105E09 nadh pyrophosphatase GE376_13865 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GE376_13905 ENOG4108XI2 Domain of unknown function (DUF1963) GE376_13930 ENOG4108NRW Phospholipase, patatin family GE376_13935 ENOG4105KWG Pfam:DUF1696 GE376_13970 ENOG4105PKS Excinuclease abc c subunit domain protein GE376_14010 ENOG4107VFR oxidoreductase GE376_14040 ENOG4105U0R haloacid dehalogenase-like hydrolase GE376_14045 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GE376_14050 ENOG4105BZU Histidine kinase GE376_14060 ENOG4105XDF Protein of unknown function (DUF1272) GE376_14085 ENOG4107WD8 ABC transporter, permease GE376_14110 ENOG4108IUM Glycogen debranching enzyme GE376_14120 ENOG4105CGH 5'-nucleotidase GE376_14135 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GE376_14145 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) GE376_14150 ENOG4105FDR Membrane GE376_14160 ENOG4105CIS alcohol dehydrogenase GE376_14165 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GE376_14210 ENOG4105MSI germination protein ypeb GE376_14245 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) GE376_14250 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) GE376_14255 ENOG4107Z3H Transcriptional regulator, TetR family GE376_14290 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family GE376_14305 ENOG4105E98 transcriptional regulator DeoR family GE376_14320 ENOG41062ES Transcriptional regulator GE376_14340 ENOG4107QKR Dehydrogenase GE376_14350 ENOG4107RUY (E1 component), alpha subunit GE376_14360 ENOG4105E1F short-chain dehydrogenase reductase GE376_14390 ENOG4107SQ8 Glycine betaine GE376_14395 ENOG4108IJ7 Glycine betaine GE376_14420 ENOG4105E66 phosphoriboisomerase A GE376_14425 ENOG41082BV acetyltransferase GE376_14430 ENOG4108M1A Chitin-binding protein GE376_14435 ENOG41087PP glycosyltransferase MGT family GE376_14455 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GE376_14460 ENOG4105MSB protein, conserved in bacteria GE376_14480 ENOG4108Z7F N-acetyltransferase GE376_14505 ENOG4105EEM helicase GE376_14535 ENOG4105C9U ATP-dependent DNA helicase RecQ GE376_14590 ENOG4108M1A Chitin-binding protein GE376_14610 ENOG4105BZG amino acid carrier protein GE376_14615 ENOG4105C26 Dehydrogenase GE376_14620 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GE376_14625 ENOG4105CTU Proline racemase GE376_14630 ENOG4105CTU Proline racemase GE376_14635 ENOG41080HI glycine oxidase GE376_14645 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein GE376_14680 ENOG4105DCI Phosphohydrolase GE376_14685 ENOG4107T5V SNARE associated Golgi GE376_14700 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD GE376_14705 ENOG4108428 Inherit from COG: -acetyltransferase GE376_14720 ENOG4105DTQ mandelate racemase muconate lactonizing GE376_14735 ENOG4107SET aldo keto reductase GE376_14770 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) GE376_14780 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GE376_14785 ENOG4105BZU Histidine kinase GE376_14790 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GE376_14810 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 GE376_14835 ENOG4105EPR degv family GE376_14895 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) GE376_14900 ENOG4106K7D Major facilitator family transporter GE376_14925 ENOG4107BMA Transglycosylase associated protein GE376_14940 ENOG41089UC methyltransferase, type 11 GE376_14975 ENOG4105CHM Aminotransferase GE376_14990 ENOG4108ZMI UPF0477 protein GE376_15005 ENOG4105DVE abc transporter atp-binding protein GE376_15055 ENOG4105C02 permease GE376_15065 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GE376_15070 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GE376_15075 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein GE376_15080 ENOG4105D7T ABC transporter GE376_15115 ENOG4108AQF aminoglycoside N(3)-acetyltransferase GE376_15155 ENOG4107VC0 DNA alkylation repair enzyme GE376_15160 ENOG4105C6T cysteine synthase GE376_15165 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase GE376_15180 ENOG4107VMI polysaccharide deacetylase GE376_15185 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC GE376_15195 ENOG4106ETB IIa component GE376_15200 ENOG4108ZCF integral membrane protein GE376_15205 ENOG4105E0M Sulfatase GE376_15210 ENOG4105C5H ABC transporter GE376_15215 ENOG4105EYF MMPL domain protein GE376_15220 ENOG41082JN Transcriptional regulator GE376_15225 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GE376_15250 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GE376_15255 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase GE376_15310 ENOG41069ER domain protein GE376_15325 ENOG4105DNP FAD linked oxidase domain protein GE376_15350 ENOG4105D4B ABC, transporter GE376_15355 ENOG4105F5R ABC transporter GE376_15370 ENOG4105DKT Transcriptional regulator GE376_15375 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) GE376_15385 ENOG41061GT Aldolase GE376_15400 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) GE376_15430 ENOG4105II7 pyrroline-5-carboxylate reductase GE376_15440 ENOG4107258 Transcriptional regulator GE376_15465 ENOG4105ECK Fatty Acid Desaturase GE376_15475 ENOG4107RBI VanW family GE376_15480 ENOG4105G6Z alkaline phosphatase GE376_15490 ENOG4105VMP Transcriptional regulator GE376_15515 ENOG41068WN GE376_15545 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GE376_15565 ENOG4105C8Y Acetylornithine aminotransferase GE376_15605 ENOG4108TVJ Nitroreductase GE376_15610 ENOG4105FS7 Transcriptional regulator GE376_15650 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GE376_15655 ENOG4105CMR udp-glucose 4-epimerase GE376_15670 ENOG4108DMH HTH_ARAC GE376_15675 ENOG4108XET gCN5-related N-acetyltransferase GE376_15690 ENOG4108PCN EamA-like transporter family GE376_15735 ENOG410635A Membrane GE376_15740 ENOG4108428 Inherit from COG: -acetyltransferase GE376_15745 ENOG4108IQI permease GE376_15755 ENOG4105F1N DNA alkylation repair GE376_15765 ENOG4105BZU Histidine kinase GE376_15770 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GE376_15780 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GE376_15815 ENOG4107RF6 penicillin-binding protein GE376_15825 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GE376_15830 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) GE376_15845 ENOG4105E7W lamb ycsf family protein GE376_15855 ENOG4105P4J Allophanate hydrolase, subunit 1 GE376_15860 ENOG4107258 Transcriptional regulator GE376_15870 ENOG4106N3A copper homeostasis protein cutc GE376_15875 ENOG4108ZHR arsR family transcriptional regulator GE376_15885 ENOG4105FDT acyl-CoA dehydrogenase GE376_15910 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GE376_15930 ENOG4105DWD nucleoside recognition domain protein GE376_15975 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GE376_16000 ENOG4105E2A Dehydrogenase GE376_16010 ENOG4105CN5 Metallo-Beta-Lactamase GE376_16020 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GE376_16035 ENOG4105CGH 5'-nucleotidase GE376_16045 ENOG4105CHJ isochorismatase hydrolase GE376_16070 ENOG41090MY MarR family Transcriptional regulator GE376_16135 ENOG4105E1K spore germination protein GE376_16150 ENOG4108606 TspO/MBR family GE376_16155 ENOG4105CVP deoxyribo-dipyrimidine photolyase GE376_16180 ENOG4108TWJ NADH dehydrogenase subunit 5 GE376_16185 ENOG4105GPN Uncharacterized conserved protein (DUF2294) GE376_16190 ENOG4107VMI polysaccharide deacetylase GE376_16200 ENOG4105KY5 gCN5-related N-acetyltransferase GE376_16205 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GE376_16230 ENOG4105Z7P Acetyltransferase (GNAT) family GE376_16240 ENOG4105D6J arsenicaL-resistance protein GE376_16245 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase GE376_16250 ENOG41085FC arsR family transcriptional regulator GE376_16260 ENOG4105NAE bifunctional deaminase-reductase domain protein GE376_16285 ENOG4107P5I polyketide synthase GE376_16290 ENOG4108IG5 Transcriptional regulator GE376_16340 ENOG4105F27 Major Facilitator GE376_16345 ENOG4105M4P Tetr family transcriptional regulator GE376_16350 ENOG4105CHR reductase GE376_16355 ENOG4108YXU transcriptional regulator AsnC family GE376_16430 ENOG4105C44 Serine transporter GE376_16455 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase GE376_16460 ENOG4105DUM transcriptional regulator, lysR family GE376_16465 ENOG4105DWP Membrane GE376_16490 ENOG4105N0V mono-oxygenase ydhR GE376_16520 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GE376_16525 ENOG41062D9 Histidine kinase GE376_16565 ENOG4105C19 ABC transporter GE376_16595 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GE376_16600 ENOG4105C0R drug resistance transporter emrb qaca subfamily GE376_16615 ENOG4105K6H D-cysteine desulfhydrase GE376_16630 ENOG4105JQZ Methyltransferase GE376_16650 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) GE376_16670 ENOG4105BZU Histidine kinase GE376_16680 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) GE376_16705 ENOG4108JQ1 Dehydrogenase GE376_16710 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GE376_16735 ENOG4108IBT Inherit from COG: transposase GE376_16760 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase GE376_16780 ENOG4108VXD carboxy-peptidase GE376_16785 ENOG4105PNM synthesis protein GE376_16795 ENOG4108ISG Major Facilitator GE376_16810 ENOG4107MII Sugar-specific transcriptional regulator TrmB GE376_16815 ENOG4105CZM Major Facilitator GE376_16830 ENOG4105DA5 (ABC) transporter GE376_16835 ENOG41069JR GE376_16850 ENOG4105CRW Short chain fatty acid transporter GE376_16860 ENOG4105DYS nad(p)h dehydrogenase (quinone) GE376_16920 ENOG4108K8S endonuclease I GE376_16950 ENOG4108Z66 YbaK ebsC protein GE376_16970 ENOG4105KVH Transcriptional regulator GE376_16975 ENOG4108RCM Nitroreductase GE376_17005 ENOG4108PSK reductase GE376_17075 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase GE376_17080 ENOG4105DKQ ROK family GE376_17090 ENOG4108UW5 maltose o-acetyltransferase GE376_17095 ENOG4105C31 Tryptophanyl-tRNA synthetase GE376_17160 ENOG4105C37 (CBS) domain GE376_17175 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase GE376_17180 ENOG4105FAW cDP-glucose 4,6-dehydratase GE376_17210 ENOG4105DDN Pentapeptide repeat-containing protein GE376_17215 ENOG4105XDF Protein of unknown function (DUF1272) GE376_17220 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) GE376_17225 ENOG4105CMG Carbohydrate kinase GE376_17230 ENOG4105C6Z Gluconate GE376_17245 ENOG4105CV1 Transketolase (EC 2.2.1.1) GE376_17250 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase GE376_17255 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase GE376_17260 ENOG4105CIS alcohol dehydrogenase GE376_17265 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone GE376_17280 ENOG4105EWI Short-chain dehydrogenase reductase Sdr GE376_17295 ENOG4105C8Q Methyl-accepting chemotaxis GE376_17300 ENOG4108UX3 '-nucleotidase GE376_17305 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GE376_17310 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GE376_17315 ENOG4105KVH Transcriptional regulator GE376_17330 ENOG4105CV8 reductase GE376_17335 ENOG4105F27 Major Facilitator GE376_17360 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA GE376_17365 ENOG4105CHH sulfate transporter GE376_17380 ENOG4105C44 Serine transporter GE376_17415 ENOG4105KVH Transcriptional regulator GE376_17420 ENOG4108TZY GntR Family Transcriptional Regulator GE376_17425 ENOG4105D9R oxidoreductase GE376_17430 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GE376_17435 ENOG4105KVH Transcriptional regulator GE376_17440 ENOG4105KVH Transcriptional regulator GE376_17490 ENOG4105JAB phenazine biosynthesis protein, phzf family GE376_17500 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GE376_17505 ENOG4105KVH Transcriptional regulator GE376_17525 ENOG4108ZJ4 polysaccharide deacetylase GE376_17605 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) GE376_17615 ENOG4107YXZ hydrolase, family 25 GE376_17650 ENOG4105H3G oxidoreductase GE376_17720 ENOG4108TN2 lmbE family GE376_17730 ENOG4107R3E Citrate transporter GE376_17745 ENOG4108MES Periplasmic binding protein GE376_17750 ENOG4105EHG Permease protein GE376_17755 ENOG4105DQ5 transport system permease protein GE376_17760 ENOG4105NX3 Membrane GE376_17780 ENOG4107CUJ Protein of unknown function (DUF2690) GE376_17790 ENOG4107V2S Transcriptional regulator GE376_17810 ENOG4105C98 muts2 protein GE376_17820 ENOG4105E5K Alpha-amylase GE376_17825 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase GE376_17830 ENOG4105DPN Oligoendopeptidase f GE376_17855 ENOG4105FFC UPF0187 protein GE376_17870 ENOG4108A04 Beta-lactamase GE376_17895 ENOG4107VXM glycerophosphoryl diester phosphodiesterase GE376_17935 ENOG41082BM Transcriptional regulator, arsr family GE376_17940 ENOG4105CIS alcohol dehydrogenase GE376_17945 ENOG4105CNG UPF0061 protein GE376_17950 ENOG4107JM4 Tetratricopeptide repeat GE376_17980 ENOG4105CQB FAD linked oxidase domain protein GE376_18005 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase GE376_18020 ENOG4105CEP NADH dehydrogenase GE376_18035 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C GE376_18040 ENOG4108M1A Chitin-binding protein GE376_18055 ENOG4105E1K spore germination protein GE376_18075 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase GE376_18085 ENOG4108IAJ Nad-dependent epimerase dehydratase GE376_18090 ENOG4105FAW cDP-glucose 4,6-dehydratase GE376_18145 ENOG4105BZU Histidine kinase GE376_18150 ENOG4105C5H ABC transporter GE376_18155 ENOG41067SE Tetr family transcriptional regulator GE376_18160 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity GE376_18170 ENOG4108VXD carboxy-peptidase GE376_18175 ENOG4107DUR UPF0457 protein GE376_18195 ENOG4105BZU Histidine kinase GE376_18205 ENOG4105KT7 mgtC SapB transporter GE376_18215 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase GE376_18220 ENOG41073R8 VanW family GE376_18230 ENOG4108R1P GE376_18245 ENOG4105VEQ Cold shock protein GE376_18265 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GE376_18285 ENOG410904N short-chain dehydrogenase reductase GE376_18295 ENOG4106IQC argininosuccinate lyase GE376_18310 ENOG4108IA2 Sodium pantothenate symporter GE376_18320 ENOG4105C26 Dehydrogenase GE376_18325 ENOG4105CHR reductase GE376_18335 ENOG4105EWU Squalene--hopene cyclase GE376_18345 ENOG4105FR1 rard protein GE376_18350 ENOG410696E Membrane GE376_18365 ENOG4105D1F ATP-binding protein GE376_18375 ENOG4108ZAF Molybdopterin GE376_18380 ENOG4105CVM Molybdenum cofactor synthesis domain protein GE376_18385 ENOG4105D06 uba thif-type nad fad binding protein GE376_18390 ENOG4105TMB Formate nitrite transporter GE376_18400 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GE376_18405 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) GE376_18415 ENOG4108JB9 formate dehydrogenase GE376_18420 ENOG4105E1K spore germination protein GE376_18435 ENOG4105CUB amino acid GE376_18490 ENOG4108KGH TRANSCRIPTIONal GE376_18500 ENOG4105EMN RNA polymerase sigma factor GE376_18510 ENOG4105CIG ABC transporter GE376_18530 ENOG4105D9R oxidoreductase GE376_18540 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GE376_18545 ENOG4105K4P CoA-binding domain protein GE376_18550 ENOG4105C0H protease GE376_18555 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GE376_18565 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase GE376_18570 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GE376_18575 ENOG4105W8X HesB YadR YfhF-family protein GE376_18600 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) GE376_18605 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GE376_18615 ENOG4105BZ1 (ABC) transporter GE376_18620 ENOG4108I0Z Aconitate hydratase GE376_18650 ENOG4105E5W Transporter GE376_18660 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GE376_18680 ENOG4107F3J Amp-dependent synthetase and ligase GE376_18685 ENOG4107ZYJ bioY protein GE376_18690 ENOG4105CEY Amp-dependent synthetase and ligase GE376_18700 ENOG4105BZU Histidine kinase GE376_18715 ENOG4105C19 ABC transporter GE376_18730 ENOG4105CJ1 ABC, transporter GE376_18815 ENOG4107AYK membrAne GE376_18830 ENOG4105BZU Histidine kinase GE376_18835 ENOG4105FBA Phospholipase Carboxylesterase GE376_18840 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase GE376_18845 ENOG4105CK7 Sodium proline symporter GE376_18850 ENOG4105CBC glutamate synthase GE376_18855 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GE376_18860 ENOG4108VJ1 Transcriptional regulator (CarD family GE376_18865 ENOG4108903 Formimidoylglutamase GE376_18890 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) GE376_18920 ENOG4107QIV Cytochrome c biogenesis protein GE376_18935 ENOG4105CH2 amidohydrolase GE376_18945 ENOG4105CJ1 ABC, transporter GE376_18960 ENOG4107RSM transcriptional regulator GE376_18965 ENOG4105VAW lrga family GE376_18970 ENOG41067MG lrgb family GE376_19010 ENOG4105BZ1 (ABC) transporter GE376_19015 ENOG4105BZ1 (ABC) transporter GE376_19050 ENOG4108HW3 (ABC) transporter GE376_19055 ENOG4105CGH 5'-nucleotidase GE376_19065 ENOG4108SVB resolvase GE376_19085 ENOG4105K7K Transcriptional regulator GE376_19090 ENOG4105C5F glutamine synthetase GE376_19095 ENOG4105KV4 Transcriptional regulator GE376_19100 ENOG4105CXI aluminum resistance protein GE376_19105 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GE376_19110 ENOG4105EN6 Membrane GE376_19115 ENOG4106F1P AAA ATPase, central domain protein GE376_19145 ENOG41069ER domain protein GE376_19160 ENOG4105DM4 PTS System GE376_19165 ENOG4105DE4 1-phosphofructokinase GE376_19170 ENOG4105E98 transcriptional regulator DeoR family GE376_19175 ENOG4107QW4 alcohol dehydrogenase GE376_19180 ENOG4108SJC Membrane GE376_19190 ENOG4105C85 amino acid GE376_19210 ENOG4105TMB Formate nitrite transporter GE376_19215 ENOG4105K70 DNA-binding protein GE376_19225 ENOG4105C59 p-type ATPase GE376_19230 ENOG410681U heavy metal transport detoxification protein GE376_19235 ENOG4105VPX protein, conserved in bacteria GE376_19245 ENOG4105NIV Esterase GE376_19250 ENOG4105E0A ABC, transporter GE376_19270 ENOG4105CGK Exodeoxyribonuclease III GE376_19280 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GE376_19285 ENOG4105D03 DNA-3-methyladenine glycosylase II GE376_19315 ENOG4105BZU Histidine kinase GE376_19355 ENOG41067MG lrgb family GE376_19375 ENOG4108S3Y transcriptional regulator GE376_19380 ENOG4105CS2 ec 3.2.1.21 GE376_19395 ENOG4105F0V Cell wall hydrolase GE376_19410 ENOG4105E0M Sulfatase GE376_19415 ENOG410890F Dynamin family GE376_19450 ENOG4105DQU oxidoreductase, subunit beta GE376_19455 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein GE376_19460 ENOG4108IGT Dipeptidase GE376_19465 ENOG4105MCT stage V sporulation protein S GE376_19470 ENOG4105D48 metallophosphoesterase GE376_19490 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase GE376_19505 ENOG4105XZV Protein of unknown function (DUF3243) GE376_19510 ENOG4108RKS Short-chain dehydrogenase reductase Sdr GE376_19530 ENOG4105UIB (ABC) transporter GE376_19535 ENOG4108JQ9 ABC transporter GE376_19540 ENOG4105DIH basic membrane GE376_19545 ENOG4105FDP GntR family transcriptional regulator GE376_19555 ENOG4105CNU cell division protein FtsK GE376_19565 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit GE376_19575 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GE376_19585 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GE376_19590 ENOG4108S0H Dipicolinic acid synthetase, b subunit GE376_19665 ENOG4105CDU Replicative dna helicase GE376_19730 ENOG4105E35 Dipicolinate synthase subunit A GE376_19740 ENOG4105C1V Peptidase, M16 GE376_19760 ENOG4105DTN riboflavin biosynthesis protein ribF GE376_19775 ENOG4105W7A Protein of unknown function (DUF503) GE376_19785 ENOG4105VHM ribosomal protein GE376_19790 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination GE376_19795 ENOG4105CHV Transcription elongation factor NusA GE376_19805 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) GE376_19815 ENOG4105DZP Membrane-associated zinc metalloprotease GE376_19820 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GE376_19825 ENOG4105KNE Phosphatidate cytidylyltransferase GE376_19830 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GE376_19840 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GE376_19870 ENOG4108HE4 integrase family GE376_19880 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GE376_19885 ENOG4105C79 DNA protecting protein DprA GE376_19890 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha GE376_19905 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) GE376_19930 ENOG4105VB6 UPF0109 protein GE376_19950 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GE376_19955 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) GE376_19970 ENOG4105CHR reductase GE376_19975 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GE376_19990 ENOG4105CB5 ATP-dependent DNA helicase recG GE376_19995 ENOG4105DP4 dak2 domain fusion protein ylov GE376_20000 ENOG4108ZAA Alkaline-shock protein GE376_20015 ENOG4105FJ0 thiamine GE376_20020 ENOG4105DJV ribulose-phosphate 3-epimerase GE376_20025 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GE376_20030 ENOG4105D9P serine threonine protein kinase GE376_20035 ENOG4108ZF3 Phosphatase GE376_20045 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GE376_20060 ENOG4105C25 Primosomal protein n' GE376_20065 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase GE376_20085 ENOG4105DSJ YicC domain protein GE376_20095 ENOG4105F23 Fibronectin-binding protein GE376_20105 ENOG4105DC7 peptidase M24 GE376_20155 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) GE376_20190 ENOG4105C34 Pseudouridine synthase GE376_20205 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GE376_20215 ENOG4105DBK s4 domain protein GE376_20220 ENOG41067XK integral membrane protein GE376_20230 ENOG4105DFA alanine racemase domain protein GE376_20235 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GE376_20240 ENOG4105WR5 sporulation protein, YlmC YmxH family GE376_20250 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GE376_20260 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GE376_20265 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GE376_20275 ENOG4105D4A Cell wall formation (By similarity) GE376_20280 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GE376_20285 ENOG4105CNI cell division protein FtsW GE376_20300 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GE376_20305 ENOG4105CJN penicillin-binding protein GE376_20310 ENOG4105CJN penicillin-binding protein GE376_20325 ENOG41074B2 UPF0747 protein GE376_20350 ENOG4105KNH Nucleic acid-binding protein GE376_20360 ENOG41063PX domain protein GE376_20365 ENOG4105D78 K07001 NTE family protein GE376_20370 ENOG4105H20 Sporulation integral membrane protein YlbJ GE376_20380 ENOG4106H78 methyltransferase GE376_20400 ENOG4107TB6 phosphoglycerate mutase GE376_20415 ENOG4106UY4 Inherit from COG: Scp-like extracellular GE376_20465 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) GE376_20475 ENOG4105CNI cell division protein FtsW GE376_20490 ENOG4108IAB Phoh family GE376_20510 ENOG4105QA2 GE376_20515 ENOG4105CI3 gtp-binding protein typa GE376_20525 ENOG4105ECY inositol monophosphatase GE376_20545 ENOG4105CXN decarboxylase GE376_20595 ENOG4105CPP Dehydrogenase, E1 component GE376_20610 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GE376_20615 ENOG4108X4Q Hydrolase GE376_20630 ENOG4105CN5 Metallo-Beta-Lactamase GE376_20635 ENOG4107ZYR domain protein GE376_20670 ENOG4108XRC Protein of unknown function (DUF458) GE376_20675 ENOG4107IN1 Protein of unknown function (DUF1797) GE376_20690 ENOG4105EPM Diguanylate phosphodiesterase GE376_20695 ENOG4105K6S Short-chain dehydrogenase reductase Sdr GE376_20710 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GE376_20720 ENOG4105UIN GE376_20755 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) GE376_20775 ENOG4108HGU Histidine kinase GE376_20785 ENOG4105CHM Aminotransferase GE376_20790 ENOG4105FKQ transcriptional regulator GE376_20795 ENOG4105EG2 ABC transporter, permease GE376_20805 ENOG4107FKK extracellular solute-binding protein family 1 GE376_20815 ENOG4105CG3 alpha amylase, catalytic region GE376_20860 ENOG4105CHU acetyl-coa acetyltransferase GE376_20895 ENOG4105K7K Transcriptional regulator GE376_20900 ENOG4105DTD Dehydrogenase GE376_20920 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GE376_20945 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) GE376_20960 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GE376_20970 ENOG4105BZU Histidine kinase GE376_20990 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GE376_21005 ENOG4105CID antiterminator GE376_21015 ENOG4105FDP GntR family transcriptional regulator GE376_21025 ENOG4105CE4 GlcNAc 6-P deacetylase GE376_21065 ENOG4107ZE5 PPIases accelerate the folding of proteins GE376_21070 ENOG4105PTM secreted protein GE376_21075 ENOG4105J7I hydrolase GE376_21085 ENOG4105G6R Stage v sporulation protein ae GE376_21095 ENOG4105CZ3 stage V sporulation protein ad GE376_21100 ENOG41090VF Stage v sporulation protein ac GE376_21120 ENOG4105C8J )-transporter GE376_21125 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GE376_21135 ENOG41082AN stage II sporulation protein GE376_21140 ENOG4105DZ1 carboxypeptidase GE376_21150 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GE376_21155 ENOG4105DVE abc transporter atp-binding protein GE376_21190 ENOG4105D7N magnesium and cobalt transport protein CorA GE376_21215 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GE376_21225 ENOG4105I3K Ferric uptake regulator, Fur family GE376_21230 ENOG4105MZ9 stage II sporulation protein m GE376_21250 ENOG4105CPC Aldo Keto reductase GE376_21260 ENOG4105RHY Pfam:UPF0157 GE376_21280 ENOG4107SKW Inherit from COG: Alpha beta hydrolase GE376_21290 ENOG4105ETE Transcriptional regulator (LacI family GE376_21295 ENOG4108YM7 Gcn5-related n-acetyltransferase GE376_21320 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GE376_21325 ENOG4108R6K riboflavin synthase, subunit alpha GE376_21350 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GE376_21355 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GE376_21370 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GE376_21380 ENOG4105DFD Na H antiporter GE376_21385 ENOG4105CGH 5'-nucleotidase GE376_21410 ENOG4105DBV ornithine carbamoyltransferase GE376_21425 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) GE376_21440 ENOG4108IXY short-chain dehydrogenase reductase GE376_21445 ENOG41069FQ Metallo-beta-lactamase superfamily GE376_21450 ENOG4105II7 pyrroline-5-carboxylate reductase GE376_21455 ENOG4105EJQ L-serine dehydratase GE376_21485 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic GE376_21505 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GE376_21510 ENOG4105D9U N-acetyltransferase GE376_21525 ENOG4108VZI ErfK ybiS ycfS ynhG family protein GE376_21530 ENOG4108QEG Membrane GE376_21535 ENOG4105CDA abc transporter atp-binding protein GE376_21540 ENOG4105E5Q amino acid AbC transporter GE376_21545 ENOG4108HW3 (ABC) transporter GE376_21555 ENOG4105G7B Protein of unknown function (DUF2992) GE376_21565 ENOG4108QY0 Membrane GE376_21575 ENOG4105C7S Dehydrogenase GE376_21580 ENOG4105CPP Dehydrogenase, E1 component GE376_21595 ENOG4105CKM Branched-chain carboxylic acid kinase GE376_21600 ENOG4107RDP Dehydrogenase GE376_21615 ENOG4108JUB Transcriptional regulator GE376_21625 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GE376_21640 ENOG4107QQR Sporulation GE376_21650 ENOG4105S1Z Stage IV sporulation protein B GE376_21655 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GE376_21660 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) GE376_21665 ENOG4105DX0 Hemolysin A GE376_21675 ENOG4105CTB Polyprenyl synthetase GE376_21690 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GE376_21700 ENOG4108ZSR alkaline shock protein GE376_21705 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GE376_21730 ENOG410644B Stage III sporulation protein af GE376_21740 ENOG4105KQ4 Stage iii sporulation protein ad GE376_21745 ENOG4108CQH stage III sporulation protein AC GE376_21750 ENOG4105KR5 Stage iii sporulation protein GE376_21755 ENOG4105CD2 stage iii sporulation protein aa GE376_21780 ENOG4105DC7 peptidase M24 GE376_21785 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GE376_21795 ENOG4105CBJ Metal-dependent enzyme GE376_21805 ENOG4107YBY Hydrolase GE376_21835 ENOG41082GG biotin lipoate A B protein ligase GE376_21840 ENOG4105WZW rhodanese family GE376_21865 ENOG41080TC multidrug resistance protein GE376_21900 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GE376_21935 ENOG4105C0D helicase GE376_22020 ENOG4107R6U sodium dicarboxylate symporter GE376_22065 ENOG4105D7V transposase GE376_22075 ENOG4105C3R Methionine synthase GE376_22085 ENOG4105C28 cystathionine GE376_22090 ENOG4105C28 cystathionine GE376_22110 ENOG4105C5X domain protein GE376_22120 ENOG4105DKQ ROK family GE376_22130 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase GE376_22150 ENOG4108UTW Plays a role in the regulation of phosphate uptake GE376_22155 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GE376_22160 ENOG4105C8U phosphate abc transporter GE376_22165 ENOG4105C8U phosphate abc transporter GE376_22170 ENOG4105EXS phosphate abc transporter GE376_22175 ENOG4107RF6 penicillin-binding protein GE376_22185 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GE376_22210 ENOG4105N80 Ferric uptake regulator, Fur family GE376_22220 ENOG4105FDK ABC transporter GE376_22225 ENOG4108JYZ YitT family GE376_22230 ENOG41069ZM Protein of unknown function (DUF2624) GE376_22255 ENOG4105EGD dinuclear metal center protein, YbgI family GE376_22270 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GE376_22275 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GE376_22300 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GE376_22305 ENOG4105KG3 cytidine deaminase GE376_22310 ENOG4107YR5 Diacylglycerol kinase GE376_22315 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GE376_22320 ENOG4105CTJ Metal Dependent Phosphohydrolase GE376_22325 ENOG4105C9A Phoh family GE376_22335 ENOG41068P3 sporulation protein YqfC GE376_22345 ENOG4105KTH gatB Yqey GE376_22355 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GE376_22360 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GE376_22390 ENOG4105CSA Coproporphyrinogen iii oxidase GE376_22395 ENOG4105KVH Transcriptional regulator GE376_22420 ENOG4105TQK DNA polymerase iii, delta' subunit GE376_22430 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 GE376_22435 ENOG4108UK2 deaminase GE376_22440 ENOG4105KQC Competence protein GE376_22450 ENOG4105DXX methyltransferase GE376_22460 ENOG4108WF2 Metal Dependent Phosphohydrolase GE376_22470 ENOG410812S Rna-binding protein GE376_22480 ENOG4105CQW ribosome biogenesis GTPase YqeH GE376_22485 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase GE376_22500 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GE376_22520 ENOG4108TVJ Nitroreductase GE376_22535 ENOG4105G6Z alkaline phosphatase GE376_22540 ENOG4105KEG ribosomal-protein-alanine acetyltransferase GE376_22545 ENOG4108MUZ hydrolase GE376_22580 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin GE376_22585 ENOG4105MIR Phenylalanine 4-monooxygenase GE376_22595 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase GE376_22635 ENOG4105S6R Iron-hydroxamate transporter permease subunit GE376_22640 ENOG4108V5C ABC transporter GE376_22655 ENOG4108EKI Dehydrogenase GE376_22660 ENOG4105C28 cystathionine GE376_22690 ENOG4107XRG penicillin-binding protein GE376_22695 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GE376_22705 ENOG4105CFP Peptidase U32 GE376_22710 ENOG4105XYU peptidase (U32 family) GE376_22715 ENOG4108VQJ O-methyltransferase GE376_22720 ENOG4105HHA aminodeoxychorismate lyase GE376_22740 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GE376_22750 ENOG4105C02 permease GE376_22765 ENOG41060CR GE376_22770 ENOG4105C7H Helicase, RecD TraA family GE376_22780 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GE376_22785 ENOG4105C3J Cysteine desulfurase GE376_22795 ENOG4105D1H recombination factor protein RarA GE376_22800 ENOG4108VCI transcription factor, rsfa family GE376_22810 ENOG4105CUZ uba thif-type nad fad binding protein GE376_22820 ENOG4105CUT histidyl-tRNA synthetase GE376_22825 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) GE376_22830 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GE376_22840 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GE376_22845 ENOG41076HS cation diffusion facilitator family transporter GE376_22850 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GE376_22860 ENOG4105CKP Polysaccharide Biosynthesis Protein GE376_22865 ENOG4108QG2 Membrane GE376_22875 ENOG4105VIE preprotein translocase, subunit YajC GE376_22890 ENOG41061AI Protein of unknown function (DUF2905) GE376_22905 ENOG4108HUF Transporter GE376_22935 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GE376_22940 ENOG4108IYU L-aspartate oxidase GE376_22955 ENOG4108RPX mosc domain containing protein GE376_22960 ENOG4105CQC Prephenate dehydratase GE376_22975 ENOG4105C19 ABC transporter GE376_22980 ENOG4105EWM Histidine kinase GE376_22990 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GE376_23005 ENOG4105X36 (ribosomal) protein GE376_23015 ENOG4105C03 ribonuclease GE376_23030 ENOG4107QMS site-determining protein GE376_23045 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) GE376_23050 ENOG4105DFF Rod shape-determining protein mreb GE376_23075 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GE376_23080 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GE376_23090 ENOG41068KH stage VI sporulation protein D GE376_23100 ENOG4105D52 delta-aminolevulinic acid dehydratase GE376_23125 ENOG4105K56 Transcriptional regulator GE376_23145 ENOG4108IUQ atp-dependent protease GE376_23170 ENOG4108QCI YvbH-like oligomerisation region GE376_23190 ENOG4105M59 Phosphodiesterase, mj0936 family GE376_23205 ENOG4108XJQ germination protein GE376_23215 ENOG4108PCX Major Facilitator GE376_23225 ENOG4105KBX Transcriptional regulator, TetR family GE376_23235 ENOG4105PFC Transcriptional regulator GE376_23245 ENOG4105DZC cytosine deaminase GE376_23250 ENOG41067S9 phage shock protein C, PspC GE376_23255 ENOG4108JCI Transcriptional regulator GE376_23265 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GE376_23270 ENOG4108Z40 Transcriptional regulator GE376_23275 ENOG4105RHA ABC transporter, permease GE376_23280 ENOG4108IUX (ABC) transporter GE376_23285 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family GE376_23290 ENOG4105ER2 Ompa motb domain protein GE376_23295 ENOG4105E14 MotA TolQ exbB proton channel GE376_23300 ENOG4108VXD carboxy-peptidase GE376_23310 ENOG4105E33 succinate dehydrogenase GE376_23320 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit GE376_23330 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GE376_23335 ENOG4105K63 Thioredoxin GE376_23340 ENOG4105C10 Electron transfer flavoprotein GE376_23345 ENOG4105BZJ Electron transfer flavoprotein GE376_23350 ENOG41060WC Enoyl-CoA hydratase GE376_23355 ENOG4107Z3H Transcriptional regulator, TetR family GE376_23360 ENOG4105CEY Amp-dependent synthetase and ligase GE376_23370 ENOG4105J76 Periplasmic binding protein GE376_23375 ENOG4105S6R Iron-hydroxamate transporter permease subunit GE376_23420 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GE376_23430 ENOG4105DR4 Methyltransferase GE376_23440 ENOG4105KFN sortase, SrtB family GE376_23445 ENOG4105E0A ABC, transporter GE376_23460 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) GE376_23470 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) GE376_23480 ENOG4105FE9 pseudouridine synthase GE376_23490 ENOG4105DCG PHP domain protein GE376_23505 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GE376_23525 ENOG4105C5S asparaginyl-tRNA synthetase GE376_23530 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GE376_23540 ENOG4108RWN rrna methyltransferase GE376_23570 ENOG4105C0R drug resistance transporter emrb qaca subfamily GE376_23575 ENOG4105CW7 secretion protein, HlyD family GE376_23580 ENOG4108JGH Tetr family transcriptional regulator GE376_23585 ENOG4105CN9 Peptidase m42 family protein GE376_23605 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GE376_23610 ENOG4105C22 threonyL-tRNA synthetase GE376_23615 ENOG4108TDW sporulation protein YtxC GE376_23640 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) GE376_23645 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GE376_23650 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GE376_23660 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GE376_23665 ENOG4105C2M dna polymerase I GE376_23670 ENOG4105BZU Histidine kinase GE376_23675 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GE376_23695 ENOG4108HMX isocitrate dehydrogenase (NADP) GE376_23700 ENOG4105BZN citrate synthase GE376_23720 ENOG4108REF Sporulation integral membrane protein ytvi GE376_23725 ENOG4105FS0 cytoplasmic membrane protein GE376_23750 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family GE376_23755 ENOG4105C6K Malic enzyme GE376_23760 ENOG4105C0B DNA polymerase III (alpha subunit) GE376_23765 ENOG4105VV2 GE376_23775 ENOG4105SFS phosphoesterase RecJ domain protein GE376_23800 ENOG4105DC7 peptidase M24 GE376_23845 ENOG4105Z7P Acetyltransferase (GNAT) family GE376_23850 ENOG41082W1 Cupin 2, conserved barrel domain protein GE376_23870 ENOG4107YZX Universal stress protein GE376_23905 ENOG4108JYZ YitT family GE376_23925 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GE376_23935 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) GE376_23940 ENOG4105KBJ sporulation protein ytfj GE376_23955 ENOG4105EFZ amidohydrolase GE376_23965 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GE376_23990 ENOG4105RQF LysR family Transcriptional regulator GE376_24000 ENOG4105U5Y Transcriptional regulator GE376_24010 ENOG4105C28 cystathionine GE376_24040 ENOG4105EMN RNA polymerase sigma factor GE376_24050 ENOG4108UW5 maltose o-acetyltransferase GE376_24060 ENOG4105F1V Acetoin utilization protein GE376_24065 ENOG4105W87 Cbs domain GE376_24070 ENOG4105DGU Histone deacetylase GE376_24075 ENOG4106HB6 Alpha beta hydrolase GE376_24085 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GE376_24090 ENOG4105BZU Histidine kinase GE376_24095 ENOG4107SNB ankyrin repeat protein YahD GE376_24100 ENOG4105EP9 oxidoreductase GE376_24125 ENOG4105ETE Transcriptional regulator (LacI family GE376_24150 ENOG4105C88 aminopeptidase GE376_24175 ENOG4108IPJ Membrane GE376_24210 ENOG4108VDD TRNA binding domain protein GE376_24240 ENOG4105C8F Beta-lactamase domain protein GE376_24255 ENOG4108V15 phosphotransferase enzyme family GE376_24260 ENOG4108IUM Glycogen debranching enzyme GE376_24270 ENOG4107QSE Dipeptidase GE376_24275 ENOG4105YW5 deoR family transcriptional regulator GE376_24290 ENOG4105CBX hi0933 family GE376_24330 ENOG4108VJ1 Transcriptional regulator (CarD family GE376_24335 ENOG4107EXU Short-chain dehydrogenase reductase Sdr GE376_24340 ENOG4105CSC Glucose uptake protein GE376_24355 ENOG4108ZAF Molybdopterin GE376_24360 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein GE376_24365 ENOG4105CVM Molybdenum cofactor synthesis domain protein GE376_24375 ENOG4105D06 uba thif-type nad fad binding protein GE376_24380 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GE376_24405 ENOG41085GJ domain protein GE376_24415 ENOG4105DWV Homoserine O-trans-acetylase GE376_24425 ENOG4108B31 Spore germination protein GE376_24450 ENOG4105C8T Leucyl-tRNA synthetase GE376_24455 ENOG410605W Major Facilitator GE376_24460 ENOG4107S91 Sodium hydrogen exchanger GE376_24465 ENOG4105NCW Trka-c domain protein GE376_24485 ENOG4105C19 ABC transporter GE376_24500 ENOG4105D7V transposase GE376_24520 ENOG4105N5T Radical SAM Protein GE376_24530 ENOG4105DA5 (ABC) transporter GE376_24565 ENOG4105E8V Alpha Beta Hydrolase Fold protein GE376_24570 ENOG4108Z0R Transferase GE376_24575 ENOG4105YVM Phosphoesterase, PA-phosphatase related GE376_24580 ENOG4105BZF Glycosyl transferase (Group 1 GE376_24590 ENOG4105EPU Molybdenum cofactor synthesis domain protein GE376_24660 ENOG4105BZU Histidine kinase GE376_24665 ENOG4105BZU Histidine kinase GE376_24670 ENOG4105CH6 catalase GE376_24675 ENOG4107S9D Alpha beta hydrolase GE376_24680 ENOG4107T7U Sulfatase GE376_24705 ENOG4105D2X ABC transporter substrate-binding protein GE376_24715 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component GE376_24780 ENOG4108V2W Carbonate dehydratase GE376_24785 ENOG4105C4M (Ubiquinol oxidase) subunit I GE376_24790 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GE376_24830 ENOG41087YS Phage shock protein A GE376_24855 ENOG4105N67 Proton-coupled thiamine transporter YuaJ GE376_24860 ENOG4105BZU Histidine kinase GE376_24865 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GE376_24890 ENOG4108UGV hypoxanthine phosphoribosyltransferase GE376_24895 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) GE376_24910 ENOG4105C19 ABC transporter GE376_24925 ENOG4107ZTW SNARE associated Golgi GE376_24940 ENOG4105C19 ABC transporter GE376_24945 ENOG41086D8 Transcriptional regulator GE376_24960 ENOG41082BM Transcriptional regulator, arsr family GE376_25010 ENOG4105C6Z Gluconate GE376_25015 ENOG4105FDP GntR family transcriptional regulator GE376_25035 ENOG41069H0 dihydroorotase EC 3.5.2.3 GE376_25055 ENOG4105DTQ mandelate racemase muconate lactonizing GE376_25060 ENOG4105CEY Amp-dependent synthetase and ligase GE376_25065 ENOG4108IPT Naphthoate synthase GE376_25070 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) GE376_25075 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) GE376_25080 ENOG4105E4F Isochorismate synthase GE376_25085 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GE376_25095 ENOG4105VEQ Cold shock protein GE376_25130 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) GE376_25135 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) GE376_25145 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin GE376_25285 ENOG4105KT7 mgtC SapB transporter GE376_25290 ENOG4107PBV potassium channel GE376_25310 ENOG4105WG9 Conserved Protein GE376_25320 ENOG4105CHM Aminotransferase GE376_25325 ENOG4108ZB6 transcriptional regulator AsnC family GE376_25330 ENOG4105C5I Dehydrogenase GE376_25335 ENOG4108MUZ hydrolase GE376_25345 ENOG4105C87 Aminotransferase class I and II GE376_25355 ENOG4105Y38 Kinase-associated protein B GE376_25365 ENOG4107R3E Citrate transporter GE376_25380 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) GE376_25385 ENOG4105KA0 thioesterase Superfamily protein GE376_25400 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GE376_25425 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) GE376_25430 ENOG4106YN8 Prenyltransferase GE376_25440 ENOG41069ER domain protein GE376_25455 ENOG4105CEP NADH dehydrogenase GE376_25485 ENOG4105EWC Purine nucleoside phosphorylase GE376_25495 ENOG4108VQJ O-methyltransferase GE376_25515 ENOG4108YX9 iron--sulfur cluster insertion protein erpA GE376_25540 ENOG4108JJA ABC, transporter GE376_25545 ENOG4105C4B ABC transporter, permease GE376_25550 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA GE376_25575 ENOG41083MR nifu domain-containing protein GE376_25590 ENOG4108W5N phosphatidylglycerophosphatase a GE376_25610 ENOG4105DAX Pfam:DUF2983 GE376_25625 ENOG4105DYS nad(p)h dehydrogenase (quinone) GE376_25630 ENOG4105D4U had-superfamily hydrolase, subfamily iia GE376_25645 ENOG4105CBT Fructose-1,6-bisphosphatase GE376_25665 ENOG4105MMD transcriptional regulator GE376_25670 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) GE376_25675 ENOG4107TXC Transcriptional regulator GE376_25680 ENOG41090T1 Membrane GE376_25715 ENOG4105FAA peptidase M23 GE376_25720 ENOG4108YTE sporulation protein YunB GE376_25725 ENOG4105KZD Domain of unknown function (DUF1805) GE376_25730 ENOG4107R8B 5'-nucleotidase GE376_25735 ENOG4105DIW FeS assembly protein SUFB GE376_25740 ENOG4108UNV SUF system FeS assembly protein, NifU family GE376_25745 ENOG4105C9B Cysteine desulfurase GE376_25750 ENOG4105JRK feS assembly protein SufD GE376_25755 ENOG4105C3K feS assembly ATPase SufC GE376_25760 ENOG4105D01 (LipO)protein GE376_25765 ENOG4105D01 (LipO)protein GE376_25770 ENOG4108UMI ABC transporter, permease GE376_25775 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GE376_25800 ENOG41080E8 Transcriptional regulator, Spx MgsR family GE376_25840 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GE376_25865 ENOG4108W8B Beta-lactamase domain protein GE376_25870 ENOG4105C1G acyl-Coa dehydrogenase GE376_25875 ENOG4105CHU acetyl-coa acetyltransferase GE376_25890 ENOG4105DZ1 carboxypeptidase GE376_25910 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer GE376_25925 ENOG4108SUT Major Facilitator Superfamily GE376_25930 ENOG4107R7I amino acid GE376_25945 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GE376_25955 ENOG4107AYK membrAne GE376_25995 ENOG4107ZTW SNARE associated Golgi GE376_26005 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GE376_26010 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GE376_26015 ENOG4105BZU Histidine kinase GE376_26040 ENOG4105C8Q Methyl-accepting chemotaxis GE376_26045 ENOG4105C8Q Methyl-accepting chemotaxis GE376_26050 ENOG4105VG1 fes assembly suf system protein GE376_26055 ENOG4105D4Y metalloprotease GE376_26060 ENOG4105C2I pirin domain protein GE376_26075 ENOG4107T5V SNARE associated Golgi GE376_26080 ENOG4107S91 Sodium hydrogen exchanger GE376_26085 ENOG4105NCW Trka-c domain protein GE376_26095 ENOG4108RMU ferritin dps family protein GE376_26115 ENOG4108URH decarboxylase GE376_26125 ENOG41090A1 ferritin GE376_26130 ENOG4105DHF Membrane GE376_26135 ENOG4105D9N nucleoside GE376_26140 ENOG4105D9N nucleoside GE376_26155 ENOG4108RYK Nad-dependent epimerase dehydratase GE376_26170 ENOG4105CV8 reductase GE376_26175 ENOG4105F27 Major Facilitator GE376_26180 ENOG4105KVH Transcriptional regulator GE376_26195 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GE376_26200 ENOG4105D4A Cell wall formation (By similarity) GE376_26220 ENOG4105WMR Protein CrcB homolog GE376_26225 ENOG4105WMR Protein CrcB homolog GE376_26240 ENOG4108MK9 spermidine N(1)-acetyltransferase GE376_26245 ENOG4108VY7 phosphate-starvation-inducible protein PsiE GE376_26255 ENOG4108W2Y isochorismatase GE376_26285 ENOG4108IPW abc transporter atp-binding protein GE376_26290 ENOG4105CM4 permease protein GE376_26330 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GE376_26340 ENOG4105XZU Preprotein translocase, subunit SecG GE376_26345 ENOG41067MG lrgb family GE376_26395 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GE376_26405 ENOG4105RHA ABC transporter, permease GE376_26410 ENOG4108IUX (ABC) transporter GE376_26415 ENOG4105BZU Histidine kinase GE376_26420 ENOG4108W5X Transcriptional Regulator, LuxR family GE376_26440 ENOG41090VF Stage v sporulation protein ac GE376_26445 ENOG4105CZ3 stage V sporulation protein ad GE376_26460 ENOG4108QY0 Membrane GE376_26465 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GE376_26470 ENOG4105KRI phosphocarrier protein (HPr GE376_26480 ENOG4105CHW UPF0052 protein GE376_26485 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GE376_26490 ENOG4108Z4K mutator MutT protein GE376_26500 ENOG4105C3M thioredoxin reductase GE376_26510 ENOG4108S4C acetyltransferase GE376_26530 ENOG41086DT Membrane protein of unknown function GE376_26535 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GE376_26555 ENOG4107TXC Transcriptional regulator GE376_26580 ENOG4105DUM transcriptional regulator, lysR family GE376_26590 ENOG4108WS4 fmn reductase GE376_26605 ENOG4105BZ1 (ABC) transporter GE376_26615 ENOG4105CN1 protease GE376_26620 ENOG4105CRP Part of the ABC transporter FtsEX involved in GE376_26625 ENOG4105CAK Cell division ATP-binding protein ftsE GE376_26645 ENOG4105MS2 ribosomal subunit Interface protein GE376_26650 ENOG4105VEQ Cold shock protein GE376_26670 ENOG4105KVH Transcriptional regulator GE376_26680 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GE376_26685 ENOG4108KGH TRANSCRIPTIONal GE376_26690 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GE376_26695 ENOG4105C6Y Udp-glucose 6-dehydrogenase GE376_26700 ENOG4105ESV Glycosyl transferase, family 4 GE376_26710 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GE376_26730 ENOG4105F8D glycoside hydrolase family 4 GE376_26735 ENOG4105VCP PTS System GE376_26740 ENOG4105CK1 PTS System GE376_26750 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GE376_26755 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) GE376_26760 ENOG4105VCP PTS System GE376_26770 ENOG4105VZJ PTS System GE376_26790 ENOG4105ECB domain protein GE376_26795 ENOG4107RSM transcriptional regulator GE376_26845 ENOG4105DAA L-lactate GE376_26855 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) GE376_26870 ENOG4105E0M Sulfatase GE376_26895 ENOG4107R8N Glycosyl transferase, family 2 GE376_26900 ENOG4105C94 Transporter GE376_26910 ENOG41069ER domain protein GE376_26935 ENOG4105KBK Zinc finger, swim domain protein GE376_26940 ENOG4105C0D helicase GE376_26970 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GE376_26980 ENOG4107RBB ABC transporter, permease GE376_26985 ENOG4105C19 ABC transporter GE376_27005 ENOG4105CXY transporter GE376_27020 ENOG4105BZU Histidine kinase GE376_27025 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GE376_27030 ENOG4105CMR udp-glucose 4-epimerase GE376_27040 ENOG4108KGH TRANSCRIPTIONal GE376_27050 ENOG4105C6Y Udp-glucose 6-dehydrogenase GE376_27075 ENOG4108KMV Glycosyl transferase (Group 1 GE376_27080 ENOG4107XU6 Glycosyl transferase (Group 1 GE376_27085 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GE376_27090 ENOG4108RYC glycosyltransferase GE376_27100 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GE376_27110 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GE376_27115 ENOG4108RB3 Capsular polysaccharide biosynthesis protein GE376_27120 ENOG4107YJ4 chain length determinant protein GE376_27125 ENOG4105HTX biosynthesis protein GE376_27130 ENOG4107YJ4 chain length determinant protein GE376_27145 ENOG4105MT0 Sporulation transcriptional regulator spoiiid GE376_27155 ENOG4105FRN stage II sporulation protein GE376_27170 ENOG4105DY9 regulatoR GE376_27190 ENOG4106778 Protein of unknown function (DUF1146) GE376_27195 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GE376_27200 ENOG4105C8S subunit m GE376_27205 ENOG4105D65 subunit l GE376_27230 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GE376_27235 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GE376_27245 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GE376_27250 ENOG4105BZU Histidine kinase GE376_27305 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) GE376_27310 ENOG41062M3 atp synthase GE376_27330 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GE376_27340 ENOG4108UIC UPF0340 protein GE376_27345 ENOG4108YZG isomerase GE376_27360 ENOG4108VGI doxx family GE376_27365 ENOG4107XC4 flavin reductase domain protein, FMN-binding GE376_27380 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GE376_27390 ENOG4108ZXQ stage ii sporulation protein r GE376_27395 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GE376_27400 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GE376_27420 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) GE376_27425 ENOG4105CBT Fructose-1,6-bisphosphatase GE376_27430 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GE376_27465 ENOG4105C1G acyl-Coa dehydrogenase GE376_27470 ENOG4105C1G acyl-Coa dehydrogenase GE376_27475 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GE376_27485 ENOG4105DF6 Fe-S oxidoreductase GE376_27500 ENOG4105BZU Histidine kinase GE376_27515 ENOG4105D4Y metalloprotease GE376_27525 ENOG4105BZU Histidine kinase GE376_27530 ENOG4105KCT ABC transporter GE376_27535 ENOG4108M15 ABC transporter GE376_27540 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) GE376_27550 ENOG4105IIU Aminopeptidase GE376_27570 ENOG4105EMN RNA polymerase sigma factor GE376_27580 ENOG410684U Domain of unknown function (DUF1934) GE376_27600 ENOG4105CYW agmatinase GE376_27610 ENOG4105DXB Major Facilitator superfamily GE376_27615 ENOG4107SWG transcriptional regulator MERR family GE376_27620 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GE376_27625 ENOG4105BZ4 penicillin-binding protein GE376_27630 ENOG4108XFG YwhD family GE376_27635 ENOG4108Z4T Peptidase M50 GE376_27640 ENOG41069HH 4-oxalocrotonate tautomerase GE376_27645 ENOG4105DCI Phosphohydrolase GE376_27650 ENOG4108MES Periplasmic binding protein GE376_27655 ENOG4105E0A ABC, transporter GE376_27660 ENOG4105EHG Permease protein GE376_27665 ENOG4105DQ5 transport system permease protein GE376_27675 ENOG4108VCI transcription factor, rsfa family GE376_27680 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) GE376_27685 ENOG4108IJ2 phosphate acetyltransferase GE376_27690 ENOG4107UEZ chlorite dismutase GE376_27700 ENOG4108VKI Cell wall hydrolase GE376_27720 ENOG4107SVH Potassium channel protein GE376_27730 ENOG410667J hydrolase GE376_27735 ENOG4105VCH membrane GE376_27745 ENOG4108TU7 Inherit from COG: (ABC) transporter GE376_27750 ENOG4105CJ1 ABC, transporter GE376_27755 ENOG41090WU lipolytic protein G-D-S-L family GE376_27770 ENOG4105D6E homoserine dehydrogenase GE376_27775 ENOG4105CVG Homoserine O-transsuccinylase GE376_27795 ENOG4108Y4K DNA-binding transcriptional activator GE376_27805 ENOG4105WH1 Two component transcriptional regulator luxr family GE376_27810 ENOG4105BZU Histidine kinase GE376_27815 ENOG4105DWF phosphomethylpyrimidine kinase GE376_27820 ENOG4105BZU Histidine kinase GE376_27825 ENOG4105VCD cytoplasmic protein GE376_27830 ENOG4105D22 carbon starvation protein GE376_27835 ENOG4105DY9 regulatoR GE376_27840 ENOG41079KZ Major Facilitator Superfamily GE376_27850 ENOG4105CG5 Glycosyl transferase (Group 1 GE376_27860 ENOG4105EN6 Membrane GE376_27865 ENOG4106YBV Methyl-accepting chemotaxis GE376_27875 ENOG4108S4H thioesterase Superfamily protein GE376_27880 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) GE376_27890 ENOG4105K64 Glycosyl transferase, family 2 GE376_27905 ENOG4108IG5 Transcriptional regulator GE376_27910 ENOG4105C5H ABC transporter GE376_27915 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein GE376_27925 ENOG41067SE Tetr family transcriptional regulator GE376_27935 ENOG4105E0X reductase GE376_27940 ENOG4106F5Q Membrane GE376_27955 ENOG4108NEV two component transcriptional regulator, LytTR family GE376_27960 ENOG4108HRK Histidine kinase GE376_27965 ENOG4107RGD Major Facilitator superfamily GE376_27985 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GE376_27995 ENOG4105IW1 AmiS UreI transporter GE376_28010 ENOG4105CMR udp-glucose 4-epimerase GE376_28015 ENOG4108UT2 hemolysin iii GE376_28025 ENOG4105C1J atp-dependent rna helicase GE376_28035 ENOG4105DPN Oligoendopeptidase f GE376_28045 ENOG4105BZU Histidine kinase GE376_28060 ENOG4105C0H protease GE376_28065 ENOG4105Q2H domain protein GE376_28080 ENOG4105BZU Histidine kinase GE376_28085 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GE376_28110 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GE376_28115 ENOG4105CDU Replicative dna helicase GE376_28125 ENOG4105BZR domain protein GE376_28130 ENOG4108XMW Membrane GE376_28140 ENOG4108UUM single-stranded DNA-binding protein GE376_28150 ENOG4105C3G gtp-binding protein GE376_28155 ENOG4105VDK protein, conserved in bacteria GE376_28160 ENOG4105D8X mechanosensitive ion channel GE376_28165 ENOG4108ZDA Sporulation protein YyaC GE376_28170 ENOG4105FA0 parb-like partition protein GE376_28175 ENOG4107QJE Chromosome Partitioning Protein GE376_28190 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) GE376_28195 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) GE376_28205 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GE376_28220 ENOG4105TRI Hydrolase GE376_28250 ENOG41067FT ParB-like nuclease domain GE376_28295 ENOG4105D4Y metalloprotease GE376_28345 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) GE376_28350 ENOG4105CJ1 ABC, transporter GE376_28415 ENOG41063PX domain protein GE376_28475 ENOG4105D7V transposase GE376_28515 ENOG4105EKQ RNA-directed DNA polymerase GE376_28535 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GE376_28565 ENOG4105D7V transposase GE376_28600 ENOG4105C5E polysaccharide biosynthesis protein GE376_28605 ENOG4105C1B dTDP-glucose 4-6-dehydratase GE376_28610 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GE376_28615 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) GE376_28630 ENOG4105D2T synthase GE376_28670 ENOG4108IND Tetr family transcriptional regulator GE376_28695 ENOG4105BZU Histidine kinase GE376_28735 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) GE376_28745 ENOG4105D4Y metalloprotease GE376_28785 ENOG4105CJW magnesium transporter GE376_28795 ENOG4105CNI cell division protein FtsW GE376_28800 ENOG4105FQP Beta-lactamase GE376_28815 ENOG4105DRR Transcriptional regulator, GntR family GE376_28840 ENOG4107QHE Choloylglycine hydrolase GE376_28855 ENOG4105CVK Glutamate decarboxylase GE376_28900 ENOG4107RA9 decarboxylase GE376_28915 ENOG4106A3M Cytochrome p-450 GE376_28925 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GE376_28940 ENOG4105C8Q Methyl-accepting chemotaxis GE376_28945 ENOG4105MZU cell filamentation protein GE376_28965 ENOG4105DVH amino acid GE376_28985 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GE376_29005 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases GE376_29045 ENOG4105CHR reductase GE376_29055 ENOG4108594 Permease of the drug metabolite transporter GE376_29060 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GE376_29070 ENOG4105DUX Transporter GE376_29090 ENOG4105CIF Ornithine Cyclodeaminase GE376_29105 ENOG4107YAK holo-(acyl carrier protein) synthase 2 GE376_29135 ENOG4105CUJ penicillin amidase GE376_29140 ENOG4105E5W Transporter GE376_29150 ENOG4108UZ3 Transporter GE376_29155 ENOG4105DRR Transcriptional regulator, GntR family GE376_29165 ENOG4108UZ3 Transporter GE376_29175 ENOG4105D7V transposase GE376_29205 ENOG4105KRN Transcriptional regulator, abrb family GE376_29210 ENOG4105K70 DNA-binding protein GE376_29225 ENOG4105K70 DNA-binding protein GE376_29235 ENOG4107SWG transcriptional regulator MERR family GE376_29285 ENOG4105KNA -acetyltransferase GE376_29290 ENOG41061CK Antibiotic biosynthesis monooxygenase GE376_29320 ENOG4105DHF Membrane GE376_29360 ENOG4108VJ1 Transcriptional regulator (CarD family GE376_29395 ENOG4105CZV ABC transporter GE376_29400 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family GE376_29505 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) GE376_29545 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GE376_29675 ENOG4105CNU cell division protein FtsK GE376_29825 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) GE376_29850 ENOG4107VUZ GE376_29985 ENOG41069ER domain protein GE376_29995 ENOG4105E4C Lytic transglycosylase catalytic GE376_30035 ENOG4105IIU Aminopeptidase GE376_30075 ENOG4105DR5 peptidase GE376_30080 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase GE376_30095 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase GE376_30100 ENOG4105D7V transposase GE376_30170 ENOG4108IMY Transcriptional regulator GE376_30185 ENOG4107VMI polysaccharide deacetylase GE376_30190 ENOG4108RZE Tetr family transcriptional regulator GE376_30195 ENOG4105CAQ asparagine synthetase GE376_30255 ENOG4105D7V transposase GE376_30260 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase GE376_30305 ENOG4105C19 ABC transporter GE376_30315 ENOG4105K70 DNA-binding protein GE376_30515 ENOG4107QRT dEAD DEAH box helicase GE376_30540 ENOG4108IMY Transcriptional regulator GE376_30590 ENOG4105CFF transcriptional regulator GE376_30660 ENOG4105E39 Enoyl-CoA hydratase GE376_30665 ENOG4105K64 Glycosyl transferase, family 2 GE376_30675 ENOG4108UT6 Transferase hexapeptide repeat containing protein GE376_30680 ENOG4108IMY Transcriptional regulator GE376_30710 ENOG4107SET aldo keto reductase GE376_30730 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GE376_30735 ENOG4105C0W non-ribosomal peptide synthetase GE376_30735 ENOG4105C0W non-ribosomal peptide synthetase GE376_30755 ENOG4105C1G acyl-Coa dehydrogenase GE376_30770 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GE376_30775 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) GE376_30790 ENOG4105C0W non-ribosomal peptide synthetase GE376_30795 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GE376_30800 ENOG4105IBP Cyclic peptide transporter GE376_30850 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase GE376_30865 ENOG4105CNW domain protein GE376_30870 ENOG4108IFG nitrite reductase, (NAD(P)H) GE376_30875 ENOG4105VCQ rubredoxin GE376_30885 ENOG4105DS0 Transcriptional regulator, Crp Fnr family GE376_30895 ENOG4105D7V transposase GE376_30910 ENOG4108QTI )-transporter GE376_30915 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GE376_30925 ENOG4107R7I amino acid GE376_30935 ENOG4105C7B Threonine dehydratase GE376_30940 ENOG4105CUB amino acid GE376_30945 ENOG4105F2M alpha beta hydrolase fold-3 domain protein GE376_30985 ENOG4105BZU Histidine kinase GE376_30990 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GE376_30995 ENOG4105C0H protease GE376_31000 ENOG4107WD8 ABC transporter, permease GE376_31020 ENOG4105D7V transposase GE376_31030 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C GE376_31045 ENOG4105CZV ABC transporter GE376_31065 ENOG4108NNZ chitinase GE376_31075 ENOG4108JUA Transcriptional regulator GE376_31080 ENOG4105CMT Dihydroxyacetone kinase GE376_31090 ENOG4105KRI phosphocarrier protein (HPr GE376_31095 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GE376_31105 ENOG4105ETZ PTS System GE376_31110 ENOG4105F3R pts system mannose fructose sorbose family iid GE376_31130 ENOG41067TZ transcriptional regulator, MarR family GE376_31135 ENOG4108ZJ4 polysaccharide deacetylase GE376_31150 ENOG4105KRN Transcriptional regulator, abrb family GE376_31160 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GE376_31180 ENOG4105RHY Pfam:UPF0157 GE376_31200 ENOG4107RSM transcriptional regulator GE376_31205 ENOG4107AYK membrAne GE376_31270 ENOG4107RF6 penicillin-binding protein GE376_31320 ENOG4108ZJ4 polysaccharide deacetylase GE376_31325 ENOG4105NA0 Transcriptional regulator GE376_31395 ENOG4105E1K spore germination protein GE376_31415 ENOG4105CSV Glutaminase GE376_31440 ENOG4105CTC Lipopolysaccharide biosynthesis protein-like protein GE376_31445 ENOG4105CJ1 ABC, transporter GE376_31450 ENOG4108KYE ABC-2 type transporter GE376_31460 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GE376_31465 ENOG4105CHR reductase GE376_31475 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GE376_31490 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GE376_31495 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GE376_31500 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) GE376_31505 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase GE376_31515 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase GE376_31555 ENOG4108J5H Homocysteine s-methyltransferase GE376_31560 ENOG4108IQI permease GE376_31565 ENOG4105DG6 mannose-6-phosphate isomerase GE376_31570 ENOG4105DM4 PTS System GE376_31610 ENOG4105KVY Required for disulfide bond formation in some proteins (By similarity) GE376_31630 ENOG4105EKQ RNA-directed DNA polymerase GE376_31655 ENOG4108Q5U germination protein, ger(x)c family GE376_31660 ENOG4105E1K spore germination protein GE376_31705 ENOG4105WH1 Two component transcriptional regulator luxr family GE376_31730 ENOG4105BZ4 penicillin-binding protein GE376_31785 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase GE376_31820 ENOG4105KIR Thiol-disulfide oxidoreductase dcc GE376_31835 ENOG4105C19 ABC transporter GE376_31855 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GE376_31865 ENOG4107VMI polysaccharide deacetylase GE376_31880 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein GE376_31895 ENOG4105BZ1 (ABC) transporter GE376_31905 ENOG4108WUH Transcriptional regulator, TetR family GE376_31925 ENOG4105C0R drug resistance transporter emrb qaca subfamily GE376_31950 ENOG41082BM Transcriptional regulator, arsr family GE376_31960 ENOG4105C0R drug resistance transporter emrb qaca subfamily GE376_31965 ENOG4108VHC Short-chain dehydrogenase reductase Sdr GE376_31995 ENOG4107RN3 metallophosphoesterase GE376_32030 ENOG41067XF inhibitor GE376_32050 ENOG4105KRN Transcriptional regulator, abrb family GE376_32090 ENOG4108EKI Dehydrogenase GE376_32125 ENOG4107R0E Glycosyl transferase, family 2 GE376_32165 ENOG4107JEE Short-chain dehydrogenase reductase Sdr