locus-tag class description C2I25_00025 ENOG4105C37 (CBS) domain C2I25_00060 ENOG4108HQR Glycine betaine C2I25_00100 ENOG4108YV3 Protein of unknown function (DUF2711) C2I25_00110 ENOG4105C6Z Gluconate C2I25_00115 ENOG4105CMG Carbohydrate kinase C2I25_00135 ENOG4107ZY0 Phenazine biosynthesis-like protein C2I25_00140 ENOG4106KNT transcriptional regulator C2I25_00145 ENOG4105WH1 Two component transcriptional regulator luxr family C2I25_00150 ENOG4105BZU Histidine kinase C2I25_00155 ENOG4105D8X mechanosensitive ion channel C2I25_00180 ENOG4105F0I Aminotransferase C2I25_00185 ENOG4108MES Periplasmic binding protein C2I25_00190 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C2I25_00205 ENOG4105CAQ asparagine synthetase C2I25_00210 ENOG4107Y70 Heat shock protein C2I25_00215 ENOG4108KF3 Electron transport protein SCO1 SenC C2I25_00225 ENOG4108RCR degv family C2I25_00240 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) C2I25_00250 ENOG4108UT2 hemolysin iii C2I25_00255 ENOG4105E9Q Acyl-transferase C2I25_00265 ENOG4107RVG penicillin-binding protein C2I25_00280 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) C2I25_00295 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 C2I25_00320 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase C2I25_00325 ENOG4105VMP Transcriptional regulator C2I25_00335 ENOG4105KD7 acetyltransferase C2I25_00355 ENOG4105CY2 Citrate transporter C2I25_00360 ENOG4107XGZ Hydrolase C2I25_00380 ENOG4105C8J )-transporter C2I25_00435 ENOG4105EC2 ftsk spoIIIe C2I25_00455 ENOG4105C5S asparaginyl-tRNA synthetase C2I25_00485 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) C2I25_00500 ENOG4105C75 arginyL-tRNA synthetase C2I25_00505 ENOG4107YX5 Pfam:DUF548 C2I25_00530 ENOG4108UUM single-stranded DNA-binding protein C2I25_00545 ENOG4105C5H ABC transporter C2I25_00600 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis C2I25_00680 ENOG41085W3 Transposase C2I25_00745 ENOG4108N0N Phage Terminase Large Subunit C2I25_00760 ENOG4108C33 Resolvase C2I25_00800 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein C2I25_00885 ENOG4105D9P serine threonine protein kinase C2I25_00900 ENOG410635T phage-like element pbsx protein C2I25_00905 ENOG4107T65 Integrase C2I25_00925 ENOG4105MCT stage V sporulation protein S C2I25_00960 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) C2I25_00965 ENOG4108IFG nitrite reductase, (NAD(P)H) C2I25_00970 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit C2I25_00975 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C2I25_00980 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein C2I25_00985 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein C2I25_01015 ENOG4108ZAF Molybdopterin C2I25_01020 ENOG4105CVM Molybdenum cofactor synthesis domain protein C2I25_01025 ENOG4105D06 uba thif-type nad fad binding protein C2I25_01030 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C2I25_01035 ENOG4107V6Q Cyclic nucleotide-binding domain C2I25_01045 ENOG4105R3A Nitrate reductase C2I25_01050 ENOG4108IUE nitrate reductase beta subunit C2I25_01060 ENOG4105C7R Atpase associated with various cellular activities aaa_3 C2I25_01075 ENOG4108V06 Glutathione peroxidase C2I25_01085 ENOG4105CNW domain protein C2I25_01100 ENOG4105EMN RNA polymerase sigma factor C2I25_01105 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein C2I25_01115 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily C2I25_01120 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) C2I25_01140 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) C2I25_01165 ENOG4105KBJ sporulation protein ytfj C2I25_01190 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) C2I25_01220 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C2I25_01225 ENOG4108JYZ YitT family C2I25_01230 ENOG41087PP glycosyltransferase MGT family C2I25_01245 ENOG4107RBS Methyltransferase C2I25_01250 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C2I25_01260 ENOG4105D94 Major Facilitator Superfamily C2I25_01265 ENOG41082F9 transcriptional regulator C2I25_01270 ENOG4108X4Q Hydrolase C2I25_01280 ENOG4108ZRV stage ii sporulation protein p C2I25_01310 ENOG4108VXD carboxy-peptidase C2I25_01325 ENOG4108ZRV stage ii sporulation protein p C2I25_01345 ENOG4108Z7R Chaperone CsaA C2I25_01375 ENOG4105C37 (CBS) domain C2I25_01380 ENOG4105SXS Protein of unknown function (DUF456) C2I25_01400 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) C2I25_01410 ENOG4108S4H thioesterase Superfamily protein C2I25_01420 ENOG4108PJD permease C2I25_01435 ENOG4107T5V SNARE associated Golgi C2I25_01480 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C2I25_01490 ENOG4105K4T epimerase C2I25_01495 ENOG4105DSE periplasmic solute binding protein C2I25_01505 ENOG4105CKI cobalamin synthesis protein C2I25_01515 ENOG4107QM2 Aldo Keto reductase C2I25_01520 ENOG4105VMI -acetyltransferase C2I25_01535 ENOG4105DEN Luciferase family C2I25_01550 ENOG4108WPJ Ferritin-like domain C2I25_01555 ENOG4108K88 Membrane C2I25_01575 ENOG4105C8Q Methyl-accepting chemotaxis C2I25_01600 ENOG4107XZQ multidrug resistance protein C2I25_01605 ENOG4105CPC Aldo Keto reductase C2I25_01610 ENOG4105YVS arsR family transcriptional regulator C2I25_01620 ENOG4105KRN Transcriptional regulator, abrb family C2I25_01670 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C2I25_01675 ENOG4108ZUB Lysine exporter protein (Lyse ygga) C2I25_01685 ENOG4105YWU small acid-soluble spore protein C2I25_01690 ENOG4108WBH protein TIM barrel C2I25_01705 ENOG4105CEY Amp-dependent synthetase and ligase C2I25_01710 ENOG4105DUU IucA IucC family protein C2I25_01720 ENOG4105VRR gCN5-related N-acetyltransferase C2I25_01725 ENOG4105KT7 mgtC SapB transporter C2I25_01735 ENOG4107VMI polysaccharide deacetylase C2I25_01740 ENOG4105BZU Histidine kinase C2I25_01745 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C2I25_01755 ENOG4108KGH TRANSCRIPTIONal C2I25_01770 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) C2I25_01780 ENOG4105D6E homoserine dehydrogenase C2I25_01800 ENOG4108ZJ4 polysaccharide deacetylase C2I25_01805 ENOG41075D4 Aminoglycoside 6-adenylyltransferase C2I25_01825 ENOG4105BZU Histidine kinase C2I25_01830 ENOG4105EFI regulatoR C2I25_01835 ENOG4105BZ1 (ABC) transporter C2I25_01885 ENOG4108UT6 Transferase hexapeptide repeat containing protein C2I25_01895 ENOG4105K64 Glycosyl transferase, family 2 C2I25_01905 ENOG4108JJ8 (ABC) transporter C2I25_01910 ENOG4108JJ9 ABC, transporter C2I25_01915 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii C2I25_01920 ENOG4105C4M (Ubiquinol oxidase) subunit I C2I25_01940 ENOG4105MDS 4-oxalocrotonate tautomerase C2I25_01950 ENOG4105SKE transcriptional Regulator LysR family C2I25_01960 ENOG4105C32 Amino acid ABC transporter (Permease) C2I25_01965 ENOG4108IV0 ABC, transporter C2I25_01970 ENOG4105C0Z ABC transporter C2I25_01980 ENOG4105CKI cobalamin synthesis protein C2I25_01995 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) C2I25_02000 ENOG4106F5Q Membrane C2I25_02005 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C2I25_02015 ENOG4108TVJ Nitroreductase C2I25_02020 ENOG4107ZXU DSBA oxidoreductase C2I25_02025 ENOG4108Z40 Transcriptional regulator C2I25_02030 ENOG4105GZI Transcriptional regulator C2I25_02035 ENOG4107RT3 EamA-like transporter family C2I25_02040 ENOG4105KTB nuclear export factor GLE1 C2I25_02045 ENOG4108T5E Copper resistance protein C2I25_02085 ENOG4105FQP Beta-lactamase C2I25_02095 ENOG4107TUM Amidinotransferase C2I25_02150 ENOG4107R16 Multicopper oxidase C2I25_02160 ENOG4107RAQ aminopeptidase C2I25_02175 ENOG410811B TRANSCRIPTIONal C2I25_02200 ENOG4105KG3 cytidine deaminase C2I25_02205 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) C2I25_02210 ENOG4105D9N nucleoside C2I25_02220 ENOG4107RHR regulatoR C2I25_02245 ENOG410849A acetyltransferase, (GNAT) family C2I25_02290 ENOG4105C0X amino acid C2I25_02295 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) C2I25_02310 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) C2I25_02330 ENOG41068WN C2I25_02355 ENOG4105CYC Transferase C2I25_02360 ENOG4105DY9 regulatoR C2I25_02365 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) C2I25_02375 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b C2I25_02380 ENOG4105C6X Major Facilitator C2I25_02400 ENOG4105C7B Threonine dehydratase C2I25_02405 ENOG4105C01 Dihydroxy-acid dehydratase C2I25_02410 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase C2I25_02420 ENOG4105C7K acetolactate synthase C2I25_02425 ENOG4105CM2 brancheD-chain amino acid aminotransferase C2I25_02430 ENOG4105CHR reductase C2I25_02435 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) C2I25_02465 ENOG4105H67 Protein of unknown function (DUF421) C2I25_02470 ENOG4105X5K response regulator receiver protein C2I25_02480 ENOG4105C8J )-transporter C2I25_02495 ENOG4105C6T cysteine synthase C2I25_02500 ENOG4105EU0 Major facilitator Superfamily C2I25_02505 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) C2I25_02515 ENOG4105DXI Major Facilitator superfamily C2I25_02525 ENOG4105U3E Transcriptional regulator C2I25_02530 ENOG4105CSR polyphosphate kinase 2 C2I25_02545 ENOG4105FVX C2I25_02610 ENOG4105C6K Malic enzyme C2I25_02615 ENOG4108IJ0 Aspartate ammonia-lyase C2I25_02625 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) C2I25_02645 ENOG4105CJ1 ABC, transporter C2I25_02685 ENOG4106BRA Membrane C2I25_02690 ENOG4105BZC d-serine deaminase C2I25_02705 ENOG4107JM4 Tetratricopeptide repeat C2I25_02720 ENOG4107QIV Cytochrome c biogenesis protein C2I25_02740 ENOG4105EC3 peptidase S51, dipeptidase E C2I25_02745 ENOG4107QJQ Mate efflux family protein C2I25_02765 ENOG4105C9Q fumarate hydratase class II C2I25_02775 ENOG4105VUF Transcriptional regulator C2I25_02780 ENOG4105DFD Na H antiporter C2I25_02795 ENOG4108PJD permease C2I25_02805 ENOG4105CKI cobalamin synthesis protein C2I25_02815 ENOG4108UZ3 Transporter C2I25_02820 ENOG4105DRR Transcriptional regulator, GntR family C2I25_02830 ENOG4105PGM cation diffusion facilitator family transporter C2I25_02850 ENOG4105CAQ asparagine synthetase C2I25_02870 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) C2I25_02880 ENOG4105CVJ phosphoglycerate mutase C2I25_02915 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component C2I25_02925 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C2I25_02930 ENOG4105DUM transcriptional regulator, lysR family C2I25_02955 ENOG4105KAC Antibiotic biosynthesis monooxygenase C2I25_02995 ENOG4105CPU Monooxygenase C2I25_03000 ENOG4105KTQ flagellar basal-body rod protein C2I25_03005 ENOG4105FZW flagellar biosynthesis regulator FlhF C2I25_03010 ENOG4105D7B Flagellar biosynthesis protein flha C2I25_03015 ENOG4105D00 flagellar biosynthetic protein flhB C2I25_03025 ENOG4105VS8 Flagellar biosynthetic protein fliq C2I25_03030 ENOG4105CN7 Flagellar biosynthetic protein FliP C2I25_03040 ENOG4105DD5 Flagellar motor switch protein C2I25_03045 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C2I25_03055 ENOG4105E4C Lytic transglycosylase catalytic C2I25_03060 ENOG4105I03 Flagellin C2I25_03065 ENOG4105I03 Flagellin C2I25_03070 ENOG4105I03 Flagellin C2I25_03075 ENOG4105I03 Flagellin C2I25_03085 ENOG4107R88 Chemotaxis protein (CheV) C2I25_03100 ENOG4105BZE flagellar hook protein, FlgE C2I25_03130 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C2I25_03135 ENOG4107U2N Flagellar M-ring protein C2I25_03140 ENOG41075Z6 flagellar hook-basal body complex protein fliE C2I25_03145 ENOG4108ZC9 flagellar basal-body rod protein flgc C2I25_03150 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) C2I25_03165 ENOG4107TPX flagellar hook-associated C2I25_03170 ENOG4105DTJ flagellar hook-associated protein C2I25_03175 ENOG4105E1Q flagellar hook-associated protein C2I25_03195 ENOG4105BZU Histidine kinase C2I25_03210 ENOG4105DD5 Flagellar motor switch protein C2I25_03215 ENOG4105CBS Chea signal transduction histidine kinase C2I25_03220 ENOG4107YTP response regulator receiver protein C2I25_03225 ENOG4105ER2 Ompa motb domain protein C2I25_03230 ENOG4107R0U MotA TolQ exbB proton channel C2I25_03240 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) C2I25_03300 ENOG41080C8 DUF218 domain C2I25_03305 ENOG4105H67 Protein of unknown function (DUF421) C2I25_03315 ENOG4108Z5V transcriptional regulator, merr family C2I25_03320 ENOG4107RWR Sodium hydrogen exchanger C2I25_03330 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C2I25_03395 ENOG41081VK Ribonuclease C2I25_03415 ENOG4108SZE gCN5-related N-acetyltransferase C2I25_03430 ENOG4105CPK Glycosyl transferase (Group 1 C2I25_03460 ENOG4105HTX biosynthesis protein C2I25_03515 ENOG4105KHC sulfurtransferase C2I25_03525 ENOG4108W0I acetyltransferase C2I25_03535 ENOG410890F Dynamin family C2I25_03545 ENOG4105DHF Membrane C2I25_03550 ENOG4105C2W permease C2I25_03560 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) C2I25_03570 ENOG4105CTD carboxy-peptidase C2I25_03575 ENOG4105DVT helicase C2I25_03585 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) C2I25_03600 ENOG4106F55 Protein of unknown function (DUF1273) C2I25_03645 ENOG4105BZ4 penicillin-binding protein C2I25_03655 ENOG4105CSM endonuclease III C2I25_03675 ENOG4105YAC C2I25_03680 ENOG4105DVT helicase C2I25_03695 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) C2I25_03720 ENOG4105CPK Glycosyl transferase (Group 1 C2I25_03725 ENOG4105FJR Lmbe family C2I25_03740 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase C2I25_03750 ENOG4108JYZ YitT family C2I25_03785 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) C2I25_03790 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) C2I25_03805 ENOG41068YB TPR repeat-containing protein C2I25_03820 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase C2I25_03825 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) C2I25_03830 ENOG4105EAH synthase C2I25_03840 ENOG4105XXQ heptaprenyl diphosphate synthase component I C2I25_03855 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) C2I25_03885 ENOG41065D1 C2I25_03890 ENOG4105S2F C2I25_03925 ENOG4107RB3 L-asparaginase C2I25_03930 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase C2I25_03955 ENOG4108S6Z Negative regulator of genetic competence C2I25_03960 ENOG4107X2D transcriptional regulator, merr family C2I25_03965 ENOG4107RGJ metallophosphoesterase C2I25_03975 ENOG4105I7S Abortive infection protein C2I25_03980 ENOG4105C9U ATP-dependent DNA helicase RecQ C2I25_03995 ENOG4108SAX Membrane C2I25_04010 ENOG4108WBT adenosyltransferase C2I25_04015 ENOG4105BZU Histidine kinase C2I25_04020 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C2I25_04025 ENOG4105CRE cytochrome C C2I25_04030 ENOG4107TWT Cytochrome c biogenesis protein C2I25_04035 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C2I25_04040 ENOG4105FE9 pseudouridine synthase C2I25_04050 ENOG4108JIC nucleoside recognition domain protein C2I25_04055 ENOG4105DZ1 carboxypeptidase C2I25_04060 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C2I25_04095 ENOG4105BZU Histidine kinase C2I25_04110 ENOG4105I3N Conserved Protein C2I25_04115 ENOG4105BZU Histidine kinase C2I25_04130 ENOG4105BZ4 penicillin-binding protein C2I25_04135 ENOG4107GRR phosphate transport regulator C2I25_04140 ENOG4105CJ3 phosphate transporter C2I25_04165 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) C2I25_04190 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) C2I25_04210 ENOG4105WH1 Two component transcriptional regulator luxr family C2I25_04215 ENOG4105ENE Histidine kinase C2I25_04235 ENOG4105DFD Na H antiporter C2I25_04255 ENOG4105C8J )-transporter C2I25_04265 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein C2I25_04270 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein C2I25_04275 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C2I25_04285 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) C2I25_04290 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) C2I25_04310 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) C2I25_04320 ENOG4105E0M Sulfatase C2I25_04325 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase C2I25_04340 ENOG4107RVV histidinol phosphate phosphatase, hisj family C2I25_04365 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) C2I25_04370 ENOG4105ECC imidazole-glycerol-phosphate dehydratase C2I25_04375 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) C2I25_04390 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C2I25_04395 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C2I25_04410 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase C2I25_04415 ENOG4108ZP8 Acetolactate synthase small subunit C2I25_04420 ENOG4105C7K acetolactate synthase C2I25_04425 ENOG4105CM2 brancheD-chain amino acid aminotransferase C2I25_04455 ENOG4105KBJ sporulation protein ytfj C2I25_04460 ENOG41063Y9 C2I25_04465 ENOG4105CZN Potassium uptake protein C2I25_04495 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) C2I25_04540 ENOG4105NQC Flavodoxin C2I25_04565 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein C2I25_04575 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD C2I25_04580 ENOG4105EA8 2-Nitropropane dioxygenase C2I25_04585 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A C2I25_04625 ENOG4105CJ1 ABC, transporter C2I25_04635 ENOG4105CZV ABC transporter C2I25_04640 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family C2I25_04645 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C2I25_04650 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C2I25_04655 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) C2I25_04700 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) C2I25_04705 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase C2I25_04710 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) C2I25_04715 ENOG4105BZU Histidine kinase C2I25_04725 ENOG4106DF1 C2I25_04735 ENOG41090MY MarR family Transcriptional regulator C2I25_04740 ENOG4105BZU Histidine kinase C2I25_04750 ENOG4105PXI polysaccharide deacetylase C2I25_04760 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) C2I25_04775 ENOG4105E98 transcriptional regulator DeoR family C2I25_04795 ENOG4107RCV ABC transporter, permease C2I25_04800 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C2I25_04805 ENOG4105C4Y ABC transporter C2I25_04840 ENOG4105CHR reductase C2I25_04860 ENOG4108Z7G MaoC domain protein dehydratase C2I25_04865 ENOG410681C small acid-soluble spore protein C2I25_04870 ENOG4105CZN Potassium uptake protein C2I25_04875 ENOG4107TS3 membrane protein, TerC C2I25_04880 ENOG4108QTI )-transporter C2I25_04890 ENOG4106A3R peptidase C2I25_04910 ENOG4105JXH GntR family transcriptional regulator C2I25_04915 ENOG4105BZU Histidine kinase C2I25_04920 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C2I25_04935 ENOG4105CQB FAD linked oxidase domain protein C2I25_04940 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) C2I25_04945 ENOG4105K4I Scp-like extracellular C2I25_04955 ENOG4108YBP pseudouridine synthase C2I25_04965 ENOG4105EYF MMPL domain protein C2I25_04975 ENOG4107RUE extracellular solute-binding protein family 1 C2I25_04980 ENOG4105D38 putrescine abc transporter C2I25_04985 ENOG4105F38 ABC transporter, permease C2I25_04990 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C2I25_04995 ENOG4105C26 Dehydrogenase C2I25_05030 ENOG4105VFR signal peptidase C2I25_05035 ENOG4105DZ1 carboxypeptidase C2I25_05065 ENOG4105RHA ABC transporter, permease C2I25_05070 ENOG4108IUX (ABC) transporter C2I25_05110 ENOG4105VZ8 Transcriptional regulator C2I25_05115 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 C2I25_05120 ENOG4105C7S Dehydrogenase C2I25_05200 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) C2I25_05210 ENOG4105DK0 Indole-3-glycerol phosphate synthase C2I25_05220 ENOG4105DDQ anthranilate synthase C2I25_05225 ENOG4105CRQ synthase (Component I) C2I25_05235 ENOG4105CK7 Sodium proline symporter C2I25_05310 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase C2I25_05320 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase C2I25_05325 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) C2I25_05345 ENOG4107TVC Glycosyl transferase, family 2 C2I25_05365 ENOG4105K64 Glycosyl transferase, family 2 C2I25_05385 ENOG4105EMS pseudouridine synthase C2I25_05390 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) C2I25_05400 ENOG4106EFP UPF0738 protein C2I25_05405 ENOG4105MIX Adenylate cyclase C2I25_05410 ENOG4108Z18 K06886 hemoglobin C2I25_05425 ENOG4105DPN Oligoendopeptidase f C2I25_05435 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) C2I25_05445 ENOG4108ZCF integral membrane protein C2I25_05470 ENOG4105UQX Mate efflux family protein C2I25_05475 ENOG4108JQ7 (ABC) transporter C2I25_05485 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C2I25_05490 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C2I25_05510 ENOG4105C31 Tryptophanyl-tRNA synthetase C2I25_05525 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) C2I25_05530 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) C2I25_05555 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit C2I25_05570 ENOG4108KP7 hydrolase C2I25_05580 ENOG41073B9 C2I25_05585 ENOG4107AYK membrAne C2I25_05595 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) C2I25_05600 ENOG4105QNR S1 RNA binding domain protein C2I25_05625 ENOG4105BZU Histidine kinase C2I25_05630 ENOG4105CH6 catalase C2I25_05635 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) C2I25_05640 ENOG4105CAQ asparagine synthetase C2I25_05650 ENOG4106BKT UPF0344 protein C2I25_05655 ENOG4105C8Y Acetylornithine aminotransferase C2I25_05665 ENOG4105ERH Fumarylacetoacetate hydrolase C2I25_05705 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C2I25_05710 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation C2I25_05745 ENOG4105VEQ Cold shock protein C2I25_05765 ENOG4107QP3 malate synthase g C2I25_05775 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) C2I25_05785 ENOG4105C8Q Methyl-accepting chemotaxis C2I25_05790 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 C2I25_05810 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C2I25_05825 ENOG41086D8 Transcriptional regulator C2I25_05830 ENOG4108AEY RNA polymerase sigma factor C2I25_05840 ENOG4105C57 major facilitator superfamily C2I25_05850 ENOG4107TVP HD domain protein C2I25_05860 ENOG4107RN3 metallophosphoesterase C2I25_05870 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) C2I25_05925 ENOG4108IJ6 ABC transporter C2I25_05930 ENOG4105ECW sulfate abc transporter C2I25_05935 ENOG4108I5D sulfate abc transporter C2I25_05940 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein C2I25_05950 ENOG4105CEY Amp-dependent synthetase and ligase C2I25_05960 ENOG4105DF9 Lipoate-protein, ligase C2I25_05965 ENOG4108RQ5 Beta-lactamase domain-containing protein C2I25_05970 ENOG4106AXD C2I25_06000 ENOG4105ECB domain protein C2I25_06015 ENOG4105NA0 Transcriptional regulator C2I25_06040 ENOG4105C1Q protoporphyrinogen oxidase C2I25_06045 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) C2I25_06055 ENOG4105BZ4 penicillin-binding protein C2I25_06060 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation C2I25_06065 ENOG4105CKV Membrane C2I25_06070 ENOG410905X membrane-flanked domain protein C2I25_06115 ENOG4105CKV Membrane C2I25_06120 ENOG410905X membrane-flanked domain protein C2I25_06180 ENOG4105K59 histidine triad (HIT) protein C2I25_06210 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) C2I25_06220 ENOG4105EEM helicase C2I25_06235 ENOG4105EMN RNA polymerase sigma factor C2I25_06265 ENOG4105C6V Glycerol-3-phosphate dehydrogenase C2I25_06280 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator C2I25_06290 ENOG4105F0F Oxalate decarboxylase C2I25_06305 ENOG4108MUZ hydrolase C2I25_06330 ENOG410829K Lysine exporter protein (Lyse ygga) C2I25_06345 ENOG4106D4I domain protein C2I25_06350 ENOG4107VRP DNA repair exonuclease C2I25_06370 ENOG4107QHE Choloylglycine hydrolase C2I25_06410 ENOG4105BZU Histidine kinase C2I25_06415 ENOG4105BZU Histidine kinase C2I25_06420 ENOG4108MJI response regulator C2I25_06430 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C2I25_06440 ENOG4105WN5 stage II sporulation protein C2I25_06485 ENOG4108WC5 Alpha Beta Hydrolase Fold protein C2I25_06535 ENOG4105CMT Dihydroxyacetone kinase C2I25_06550 ENOG4105CMT Dihydroxyacetone kinase C2I25_06565 ENOG4105WAB arsR family transcriptional regulator C2I25_06570 ENOG4105F27 Major Facilitator C2I25_06585 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase C2I25_06645 ENOG4105F6J Alpha beta hydrolase fold C2I25_06670 ENOG4105D9U N-acetyltransferase C2I25_06685 ENOG4105C0R drug resistance transporter emrb qaca subfamily C2I25_06720 ENOG4105CDU Replicative dna helicase C2I25_06770 ENOG4107SCJ type I restriction enzyme EcoKI subunit R C2I25_06805 ENOG4108MRH transcriptional regulatory protein C2I25_06815 ENOG4105CSH Transporter C2I25_06850 ENOG4108JQ7 (ABC) transporter C2I25_06860 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C2I25_06880 ENOG4105CIF Ornithine Cyclodeaminase C2I25_06905 ENOG4105DER m42 family C2I25_06925 ENOG4105CGU Enoyl-CoA hydratase C2I25_06950 ENOG4105CHH sulfate transporter C2I25_06965 ENOG4105CEY Amp-dependent synthetase and ligase C2I25_06970 ENOG4105D4P Coproporphyrinogen iii oxidase C2I25_06975 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase C2I25_07000 ENOG4107FQX Alpha-acetolactate decarboxylase C2I25_07030 ENOG4108UH6 UPF0754 membrane protein C2I25_07040 ENOG410839P C2I25_07055 ENOG4105CDA abc transporter atp-binding protein C2I25_07060 ENOG4105DRP amino acid AbC transporter C2I25_07075 ENOG4105BZ1 (ABC) transporter C2I25_07080 ENOG4105BZ1 (ABC) transporter C2I25_07100 ENOG4105C26 Dehydrogenase C2I25_07110 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) C2I25_07115 ENOG4105D5Q Arginine ornithine antiporter C2I25_07125 ENOG4107RKG DJ-1/PfpI family C2I25_07165 ENOG4105KPY Small multidrug resistance protein C2I25_07175 ENOG4105UBK short-chain dehydrogenase reductase C2I25_07180 ENOG4105CH7 arginosuccinase C2I25_07185 ENOG4108YXU transcriptional regulator AsnC family C2I25_07225 ENOG4106KNT transcriptional regulator C2I25_07235 ENOG4107RWR Sodium hydrogen exchanger C2I25_07240 ENOG4105CUB amino acid C2I25_07275 ENOG4107T5V SNARE associated Golgi C2I25_07310 ENOG4105WEF catalase C2I25_07340 ENOG4105C19 ABC transporter C2I25_07345 ENOG4107RBB ABC transporter, permease C2I25_07350 ENOG41069ER domain protein C2I25_07375 ENOG4105VZJ PTS System C2I25_07380 ENOG4105VCP PTS System C2I25_07385 ENOG4105EMD TRANSCRIPTIONal C2I25_07415 ENOG4108KGH TRANSCRIPTIONal C2I25_07425 ENOG41087NI Sulfite exporter TauE/SafE C2I25_07430 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase C2I25_07445 ENOG4105VFE sira family C2I25_07450 ENOG4107TPS domain protein C2I25_07455 ENOG4105VFE sira family C2I25_07460 ENOG4105XTG Pfam:DUF156 C2I25_07465 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase C2I25_07485 ENOG4105J4Q Transcriptional regulator C2I25_07495 ENOG4105ED1 spovr family C2I25_07500 ENOG4107Y03 Nitroreductase C2I25_07520 ENOG4108B31 Spore germination protein C2I25_07540 ENOG4105K63 Thioredoxin C2I25_07555 ENOG4105C5Y PTS System C2I25_07575 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein C2I25_07585 ENOG4105C7N Xanthine uracil vitamin C permease C2I25_07600 ENOG4105CNN ABC, transporter C2I25_07615 ENOG4105C19 ABC transporter C2I25_07640 ENOG4108INS Transcriptional regulator C2I25_07655 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) C2I25_07695 ENOG4105DWF phosphomethylpyrimidine kinase C2I25_07700 ENOG4105D06 uba thif-type nad fad binding protein C2I25_07715 ENOG41080HI glycine oxidase C2I25_07720 ENOG4108VEU Thiamine monophosphate synthase C2I25_07730 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component C2I25_07740 ENOG4105ETU transcriptional activator (TenA C2I25_07765 ENOG41080XQ Signal transduction protein with cbs domains C2I25_07900 ENOG4105E2Z phosphate ABC transporter (Permease C2I25_07905 ENOG4105C8U phosphate abc transporter C2I25_07910 ENOG4105CVA phosphate C2I25_07915 ENOG4105CE1 Ferrous iron transport protein b C2I25_07920 ENOG4105CE1 Ferrous iron transport protein b C2I25_07925 ENOG4105CE1 Ferrous iron transport protein b C2I25_07935 ENOG4108NHD germination protein C2I25_07950 ENOG4105E1V na solute symporter C2I25_07955 ENOG4106CAD Protein of unknown function (DUF3311) C2I25_07975 ENOG4105E2S oxidase) subunit II C2I25_07980 ENOG4105BZ9 Cytochrome C oxidase, subunit I C2I25_08005 ENOG4105MA6 gCN5-related N-acetyltransferase C2I25_08020 ENOG4105C7N Xanthine uracil vitamin C permease C2I25_08025 ENOG4105C85 amino acid C2I25_08045 ENOG4105DUX Transporter C2I25_08060 ENOG4107D63 C2I25_08065 ENOG4105VZ8 Transcriptional regulator C2I25_08070 ENOG41069ER domain protein C2I25_08075 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer C2I25_08080 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) C2I25_08110 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) C2I25_08150 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) C2I25_08155 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator C2I25_08160 ENOG4105CNN ABC, transporter C2I25_08165 ENOG4105C2J ABC transporter C2I25_08175 ENOG4108RVA ribokinase C2I25_08180 ENOG4105ETE Transcriptional regulator (LacI family C2I25_08185 ENOG4105C0R drug resistance transporter emrb qaca subfamily C2I25_08190 ENOG41067TZ transcriptional regulator, MarR family C2I25_08195 ENOG4105CXY transporter C2I25_08205 ENOG4108JQ7 (ABC) transporter C2I25_08210 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C2I25_08230 ENOG41068KF Universal stress protein C2I25_08235 ENOG4105CHH sulfate transporter C2I25_08250 ENOG4105BZU Histidine kinase C2I25_08260 ENOG4105NAE bifunctional deaminase-reductase domain protein C2I25_08265 ENOG4105D29 Helix-turn-helix type 11 domain protein C2I25_08280 ENOG4108IQI permease C2I25_08285 ENOG4105DRP amino acid AbC transporter C2I25_08290 ENOG4105EAD ABC transporter C2I25_08295 ENOG4105CT1 (ABC) transporter C2I25_08300 ENOG4105CDA abc transporter atp-binding protein C2I25_08305 ENOG4105BZG amino acid carrier protein C2I25_08310 ENOG4105CRN Aminoglycoside phosphotransferase C2I25_08315 ENOG4105E1K spore germination protein C2I25_08330 ENOG4105CG3 alpha amylase, catalytic region C2I25_08335 ENOG4105C5Y PTS System C2I25_08340 ENOG4107414 GntR family transcriptional regulator C2I25_08345 ENOG4105D5Q Arginine ornithine antiporter C2I25_08350 ENOG4105BZU Histidine kinase C2I25_08360 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) C2I25_08365 ENOG4105GMT ATPase associated with various cellular activities aaa_5 C2I25_08370 ENOG4107T89 von Willebrand factor, type A C2I25_08380 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) C2I25_08385 ENOG4105EXW epimerase dehydratase C2I25_08400 ENOG4105E0A ABC, transporter C2I25_08405 ENOG4108IHU transport system permease protein C2I25_08410 ENOG4105DQ5 transport system permease protein C2I25_08415 ENOG4108MES Periplasmic binding protein C2I25_08420 ENOG4105DUX Transporter C2I25_08435 ENOG4105DAA L-lactate C2I25_08440 ENOG4108IJ0 Aspartate ammonia-lyase C2I25_08445 ENOG4105C37 (CBS) domain C2I25_08450 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase C2I25_08455 ENOG4105D9N nucleoside C2I25_08460 ENOG4108KGH TRANSCRIPTIONal C2I25_08465 ENOG41073R8 VanW family C2I25_08495 ENOG4105DAP Nicotinate phosphoribosyltransferase C2I25_08500 ENOG4105C59 p-type ATPase C2I25_08520 ENOG4105CUB amino acid C2I25_08540 ENOG4108JB9 formate dehydrogenase C2I25_08545 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) C2I25_08550 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) C2I25_08565 ENOG4105BZU Histidine kinase C2I25_08575 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C2I25_08580 ENOG4108UZ3 Transporter C2I25_08590 ENOG4105C6K Malic enzyme C2I25_08600 ENOG4108MRH transcriptional regulatory protein C2I25_08625 ENOG4105US7 Histidine kinase C2I25_08630 ENOG4108STX response regulator C2I25_08635 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) C2I25_08640 ENOG4105BZ7 extracellular solute-binding protein family 1 C2I25_08645 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component C2I25_08650 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component C2I25_08655 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C2I25_08660 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator C2I25_08685 ENOG4105D4T Citrate transporter C2I25_08690 ENOG4108V9W transcriptional regulatory protein C2I25_08695 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism C2I25_08705 ENOG4105DZ6 Band 7 protein C2I25_08720 ENOG4105C94 Transporter C2I25_08750 ENOG4105CYN Serine protein kinase C2I25_08760 ENOG4105BZU Histidine kinase C2I25_08765 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) C2I25_08775 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) C2I25_08785 ENOG4108R9S DSBA oxidoreductase C2I25_08790 ENOG4108JQC penicillin-binding protein 1A C2I25_08915 ENOG4105G5W regulator Fur family C2I25_08920 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C2I25_08940 ENOG4108IUW ABC transporter C2I25_08950 ENOG4105CBC glutamate synthase C2I25_08955 ENOG4107NBY Membrane C2I25_08960 ENOG4105BZ1 (ABC) transporter C2I25_08980 ENOG4106BXE C2I25_08985 ENOG4105CEN a g-specific adenine glycosylase C2I25_08990 ENOG41067AE Membrane-bound metal-dependent hydrolase C2I25_09020 ENOG4105ECP epimerase C2I25_09025 ENOG4105CI2 imidazolone-5-propionate hydrolase C2I25_09045 ENOG4105F1A Pyruvate formate-lyase C2I25_09060 ENOG4105CKK Glycosyl transferase, family 2 C2I25_09065 ENOG4105C3I Nad-dependent epimerase dehydratase C2I25_09070 ENOG4107QQG Dehydrogenase C2I25_09075 ENOG4107R51 Glycosyl transferase, family 2 C2I25_09090 ENOG4108A04 Beta-lactamase C2I25_09140 ENOG4108IQI permease C2I25_09150 ENOG4108JUB Transcriptional regulator C2I25_09160 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) C2I25_09165 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C2I25_09200 ENOG4105UPD Calcium Proton C2I25_09205 ENOG410606W general stress protein C2I25_09220 ENOG4107ZTW SNARE associated Golgi C2I25_09240 ENOG4108IPJ Membrane C2I25_09245 ENOG4105C59 p-type ATPase C2I25_09255 ENOG4107U9T Pfam:Ribonuclease_BN C2I25_09265 ENOG4105KJF protein tyrosine phosphatase C2I25_09270 ENOG41068PA UPF0435 protein C2I25_09285 ENOG4108TTB tellurium resistance protein C2I25_09290 ENOG4107TS3 membrane protein, TerC C2I25_09295 ENOG4106FN3 tellurium resistance protein C2I25_09300 ENOG4106FN3 tellurium resistance protein C2I25_09305 ENOG4108N0M stress protein C2I25_09320 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) C2I25_09335 ENOG4105DEU major facilitator superfamily C2I25_09350 ENOG41062JF Transcriptional regulator C2I25_09385 ENOG4105C5H ABC transporter C2I25_09400 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component C2I25_09420 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter C2I25_09435 ENOG4105C9U ATP-dependent DNA helicase RecQ C2I25_09450 ENOG4105CI1 PTS System C2I25_09460 ENOG4105DNP FAD linked oxidase domain protein C2I25_09470 ENOG4108W63 CRP FNR family transcriptional regulator C2I25_09475 ENOG4105C5B carbamate kinase C2I25_09485 ENOG4105DBV ornithine carbamoyltransferase C2I25_09500 ENOG4105C8Q Methyl-accepting chemotaxis C2I25_09505 ENOG4105CDA abc transporter atp-binding protein C2I25_09510 ENOG4105EAB amino acid AbC transporter C2I25_09515 ENOG4105E5Q amino acid AbC transporter C2I25_09530 ENOG4105D2S major facilitator superfamily C2I25_09535 ENOG410756H nucleotidyltransferase C2I25_09555 ENOG4105BZU Histidine kinase C2I25_09570 ENOG4106UIA C2I25_09575 ENOG4106UIA C2I25_09595 ENOG4105CAY ferredoxin--nadp reductase C2I25_09605 ENOG4108V5C ABC transporter C2I25_09610 ENOG4105DQ5 transport system permease protein C2I25_09615 ENOG4105EHG Permease protein C2I25_09620 ENOG4107W7X Aldolase C2I25_09625 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) C2I25_09630 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) C2I25_09635 ENOG4105D3R alkyl hydroperoxide reductase C2I25_09655 ENOG4105DFD Na H antiporter C2I25_09665 ENOG4105DTQ mandelate racemase muconate lactonizing C2I25_09680 ENOG4108W15 Protein of unknown function (DUF1456) C2I25_09700 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C2I25_09705 ENOG4105D9N nucleoside C2I25_09730 ENOG4105KPY Small multidrug resistance protein C2I25_09735 ENOG4105C26 Dehydrogenase C2I25_09745 ENOG4108JPW Aminotransferase C2I25_09755 ENOG4105CBD Diacylglycerol kinase C2I25_09775 ENOG4107I77 yiaA/B two helix domain C2I25_09780 ENOG410834F Transcriptional regulator C2I25_09800 ENOG4105D01 (LipO)protein C2I25_09805 ENOG4108UMI ABC transporter, permease C2I25_09810 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C2I25_09820 ENOG4108W2Y isochorismatase C2I25_09845 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) C2I25_09850 ENOG4105C4R Atp-dependent dna helicase C2I25_09875 ENOG4105EGI Transcriptional regulator C2I25_09885 ENOG4105C12 Phosphoribosylglycinamide synthetase C2I25_09895 ENOG4108V3E phosphoribosylglycinamide formyltransferase C2I25_09920 ENOG4105VR9 phosphoribosylformylglycinamidine synthase C2I25_09930 ENOG4105C83 adenylosuccinate lyase C2I25_09935 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit C2I25_09940 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) C2I25_09965 ENOG4105SX7 Transporter C2I25_09995 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) C2I25_10040 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C2I25_10060 ENOG4107ZXU DSBA oxidoreductase C2I25_10085 ENOG4105BZU Histidine kinase C2I25_10095 ENOG4105C7N Xanthine uracil vitamin C permease C2I25_10115 ENOG4108TYN CAAX amino terminal protease family protein C2I25_10130 ENOG4105C5H ABC transporter C2I25_10135 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C2I25_10140 ENOG410801F ribosomal-protein-alanine acetyltransferase C2I25_10145 ENOG41072GX Peptidase M22 Glycoprotease C2I25_10150 ENOG4105K8N protein family UPF0079, ATPase C2I25_10255 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) C2I25_10265 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C2I25_10270 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein C2I25_10295 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) C2I25_10300 ENOG4105CPF Cell wall formation (By similarity) C2I25_10305 ENOG4108SC4 )-transporter C2I25_10310 ENOG4105CUB amino acid C2I25_10320 ENOG4105ERH Fumarylacetoacetate hydrolase C2I25_10325 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase C2I25_10355 ENOG410667J hydrolase C2I25_10360 ENOG4108JQ7 (ABC) transporter C2I25_10365 ENOG4105C3U ABC transporter C2I25_10370 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C2I25_10380 ENOG4105DEF Extracellular solute-binding protein, family 5 C2I25_10395 ENOG4105C5H ABC transporter C2I25_10420 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) C2I25_10440 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) C2I25_10465 ENOG4105F6E Acyl-transferase C2I25_10485 ENOG4105EGI Transcriptional regulator C2I25_10500 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family C2I25_10505 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein C2I25_10510 ENOG4105E0C molybdate abc transporter C2I25_10520 ENOG4106Z1T Nicotinamide Mononucleotide Transporter C2I25_10535 ENOG4108J59 Extracellular solute-binding protein, family 5 C2I25_10540 ENOG4108J59 Extracellular solute-binding protein, family 5 C2I25_10560 ENOG4108JQ7 (ABC) transporter C2I25_10565 ENOG4105C3U ABC transporter C2I25_10570 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C2I25_10575 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C2I25_10595 ENOG4105C2C drug resistance transporter, Bcr CflA C2I25_10610 ENOG4105IQ5 FAD linked oxidase domain protein C2I25_10620 ENOG4105CB2 alcohol dehydrogenase C2I25_10625 ENOG4105D01 (LipO)protein C2I25_10630 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C2I25_10635 ENOG4108UMI ABC transporter, permease C2I25_10640 ENOG4108PSK reductase C2I25_10665 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) C2I25_10680 ENOG4107U5W ybbr family C2I25_10685 ENOG4105C8B TIGR00159 family C2I25_10770 ENOG4108NMV polysaccharide deacetylase C2I25_10785 ENOG4105D1F ATP-binding protein C2I25_10810 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) C2I25_10815 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) C2I25_10820 ENOG4108JJB ABC transporter C2I25_10825 ENOG4108JJB ABC transporter C2I25_10850 ENOG41067V7 50S ribosomal protein L36 C2I25_10860 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) C2I25_10870 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) C2I25_10895 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) C2I25_11005 ENOG4105XPM ribosomal protein C2I25_11010 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C2I25_11020 ENOG4107Y49 methyltransferase C2I25_11025 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) C2I25_11045 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) C2I25_11060 ENOG4105QIV RNA polymerase C2I25_11065 ENOG4105M0M Tetracycline resistance protein C2I25_11070 ENOG4105C2N RNA methyltransferase TrmH family group 3 C2I25_11085 ENOG4105D7W serine acetyltransferase C2I25_11105 ENOG4105CTP PilT protein domain protein C2I25_11115 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) C2I25_11130 ENOG4108Z0C Uvrb UvrC protein C2I25_11220 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) C2I25_11230 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase C2I25_11235 ENOG4105KRF dihydroneopterin aldolase C2I25_11240 ENOG4105EEI dihydropteroate synthase C2I25_11245 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 C2I25_11250 ENOG4105DDQ anthranilate synthase C2I25_11255 ENOG4105CRQ synthase (Component I) C2I25_11260 ENOG4105C6T cysteine synthase C2I25_11275 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) C2I25_11280 ENOG4108UGV hypoxanthine phosphoribosyltransferase C2I25_11285 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) C2I25_11305 ENOG41060GV RNA binding s1 domain protein C2I25_11320 ENOG4105VYY sporulation protein yabp C2I25_11325 ENOG41082I2 s4 domain protein C2I25_11330 ENOG4108IY2 MazG family C2I25_11340 ENOG4108M14 stage v sporulation protein t C2I25_11345 ENOG4108JA2 transcriptioN-repair coupling factor C2I25_11355 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) C2I25_11360 ENOG4105C5T Phosphoribosyl pyrophosphate synthase C2I25_11375 ENOG4105KME endoribonuclease L-psp C2I25_11380 ENOG4105DFT pur operon repressor C2I25_11395 ENOG4105W42 Veg protein C2I25_11400 ENOG4105XFA sporulation peptidase YabG C2I25_11410 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) C2I25_11415 ENOG4105F8V Hydrolase, tatD family C2I25_11420 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) C2I25_11425 ENOG4105KRN Transcriptional regulator, abrb family C2I25_11430 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) C2I25_11440 ENOG41060K3 Methyltransferase C2I25_11450 ENOG4105MA4 psp1 domain protein C2I25_11455 ENOG4105FA2 dna polymerase iii C2I25_11465 ENOG4105CXN decarboxylase C2I25_11500 ENOG41067KS pro-sigma K processing C2I25_11520 ENOG4105C6E dna polymerase iii C2I25_11530 ENOG4108Z6B deaminase C2I25_11540 ENOG4105GTG Isochorismatase C2I25_11550 ENOG4105ZMH deoxynucleoside kinase C2I25_11585 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) C2I25_11620 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C2I25_11635 ENOG410848D S4 domain protein YaaA C2I25_11640 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) C2I25_11660 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins C2I25_11670 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) C2I25_11675 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) C2I25_11690 ENOG4107QJE Chromosome Partitioning Protein C2I25_11695 ENOG4105FA0 parb-like partition protein C2I25_11700 ENOG4108ZDA Sporulation protein YyaC C2I25_11705 ENOG4105D8X mechanosensitive ion channel C2I25_11710 ENOG4105VDK protein, conserved in bacteria C2I25_11715 ENOG4105C3G gtp-binding protein C2I25_11725 ENOG4108UUM single-stranded DNA-binding protein C2I25_11735 ENOG4108XMW Membrane C2I25_11740 ENOG4105BZR domain protein C2I25_11750 ENOG4105CDU Replicative dna helicase C2I25_11755 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis C2I25_11780 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C2I25_11785 ENOG4105BZU Histidine kinase C2I25_11800 ENOG4105Q2H domain protein C2I25_11805 ENOG4105C0H protease C2I25_11820 ENOG4105BZU Histidine kinase C2I25_11835 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) C2I25_11840 ENOG4105C1J atp-dependent rna helicase C2I25_11855 ENOG4108UT2 hemolysin iii C2I25_11885 ENOG4105CJA serine threonine protein kinase C2I25_11890 ENOG4105BZ1 (ABC) transporter C2I25_11895 ENOG4105K7K Transcriptional regulator C2I25_11915 ENOG4105DQ6 Transposase C2I25_11920 ENOG4105DQ6 Transposase C2I25_11925 ENOG4105CMR udp-glucose 4-epimerase C2I25_11935 ENOG4105IW1 AmiS UreI transporter C2I25_11945 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C2I25_11965 ENOG4107RGD Major Facilitator superfamily C2I25_11970 ENOG4108HRK Histidine kinase C2I25_11975 ENOG4108NEV two component transcriptional regulator, LytTR family C2I25_11990 ENOG4106F5Q Membrane C2I25_11995 ENOG4105E0X reductase C2I25_12005 ENOG41067SE Tetr family transcriptional regulator C2I25_12010 ENOG4105CKK Glycosyl transferase, family 2 C2I25_12025 ENOG4105C5H ABC transporter C2I25_12035 ENOG4105K64 Glycosyl transferase, family 2 C2I25_12045 ENOG4108S4H thioesterase Superfamily protein C2I25_12055 ENOG4106YBV Methyl-accepting chemotaxis C2I25_12060 ENOG4105EN6 Membrane C2I25_12070 ENOG4105CG5 Glycosyl transferase (Group 1 C2I25_12080 ENOG41079KZ Major Facilitator Superfamily C2I25_12085 ENOG4105DY9 regulatoR C2I25_12090 ENOG4105D22 carbon starvation protein C2I25_12095 ENOG4105VCD cytoplasmic protein C2I25_12100 ENOG4105BZU Histidine kinase C2I25_12105 ENOG4105DWF phosphomethylpyrimidine kinase C2I25_12110 ENOG4105BZU Histidine kinase C2I25_12115 ENOG4105WH1 Two component transcriptional regulator luxr family C2I25_12125 ENOG4108Y4K DNA-binding transcriptional activator C2I25_12145 ENOG4105CVG Homoserine O-transsuccinylase C2I25_12150 ENOG4105D6E homoserine dehydrogenase C2I25_12165 ENOG41090WU lipolytic protein G-D-S-L family C2I25_12170 ENOG4105CJ1 ABC, transporter C2I25_12175 ENOG4108TU7 Inherit from COG: (ABC) transporter C2I25_12185 ENOG4105VCH membrane C2I25_12190 ENOG410667J hydrolase C2I25_12200 ENOG4107SVH Potassium channel protein C2I25_12220 ENOG4108VKI Cell wall hydrolase C2I25_12230 ENOG4107UEZ chlorite dismutase C2I25_12235 ENOG4108IJ2 phosphate acetyltransferase C2I25_12240 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) C2I25_12245 ENOG4108VCI transcription factor, rsfa family C2I25_12255 ENOG4105DQ5 transport system permease protein C2I25_12260 ENOG4105EHG Permease protein C2I25_12265 ENOG4105E0A ABC, transporter C2I25_12270 ENOG4108MES Periplasmic binding protein C2I25_12275 ENOG4105DCI Phosphohydrolase C2I25_12280 ENOG41069HH 4-oxalocrotonate tautomerase C2I25_12285 ENOG4108Z4T Peptidase M50 C2I25_12290 ENOG4108XFG YwhD family C2I25_12295 ENOG4105BZ4 penicillin-binding protein C2I25_12300 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C2I25_12305 ENOG4107SWG transcriptional regulator MERR family C2I25_12310 ENOG4105DXB Major Facilitator superfamily C2I25_12320 ENOG4105CYW agmatinase C2I25_12345 ENOG410684U Domain of unknown function (DUF1934) C2I25_12355 ENOG4105EMN RNA polymerase sigma factor C2I25_12375 ENOG4105IIU Aminopeptidase C2I25_12385 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) C2I25_12390 ENOG4108M15 ABC transporter C2I25_12395 ENOG4105KCT ABC transporter C2I25_12400 ENOG4105BZU Histidine kinase C2I25_12410 ENOG4105D4Y metalloprotease C2I25_12425 ENOG4105BZU Histidine kinase C2I25_12440 ENOG4105DF6 Fe-S oxidoreductase C2I25_12450 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C2I25_12455 ENOG4105C1G acyl-Coa dehydrogenase C2I25_12460 ENOG4105C1G acyl-Coa dehydrogenase C2I25_12475 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) C2I25_12495 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) C2I25_12500 ENOG4105CBT Fructose-1,6-bisphosphatase C2I25_12505 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) C2I25_12525 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) C2I25_12530 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) C2I25_12535 ENOG4108ZXQ stage ii sporulation protein r C2I25_12545 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C2I25_12560 ENOG4107XC4 flavin reductase domain protein, FMN-binding C2I25_12565 ENOG4108VGI doxx family C2I25_12585 ENOG4108YZG isomerase C2I25_12590 ENOG4108UIC UPF0340 protein C2I25_12600 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) C2I25_12620 ENOG41062M3 atp synthase C2I25_12625 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) C2I25_12675 ENOG4105BZU Histidine kinase C2I25_12680 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain C2I25_12690 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain C2I25_12695 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C2I25_12720 ENOG4105D65 subunit l C2I25_12725 ENOG4105C8S subunit m C2I25_12730 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C2I25_12735 ENOG4106778 Protein of unknown function (DUF1146) C2I25_12755 ENOG4105DY9 regulatoR C2I25_12770 ENOG4105FRN stage II sporulation protein C2I25_12780 ENOG4105MT0 Sporulation transcriptional regulator spoiiid C2I25_12795 ENOG4107YJ4 chain length determinant protein C2I25_12800 ENOG4105HTX biosynthesis protein C2I25_12805 ENOG4107YJ4 chain length determinant protein C2I25_12810 ENOG4108RB3 Capsular polysaccharide biosynthesis protein C2I25_12815 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase C2I25_12825 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C2I25_12830 ENOG4105CPF Cell wall formation (By similarity) C2I25_12835 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) C2I25_12845 ENOG4107T8Q Glycosyl transferase (Group 1 C2I25_12855 ENOG4105K64 Glycosyl transferase, family 2 C2I25_12865 ENOG4108KGH TRANSCRIPTIONal C2I25_12875 ENOG4105CMR udp-glucose 4-epimerase C2I25_12880 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C2I25_12885 ENOG4105BZU Histidine kinase C2I25_12900 ENOG4105CXY transporter C2I25_12920 ENOG4105C19 ABC transporter C2I25_12925 ENOG4107RBB ABC transporter, permease C2I25_12935 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C2I25_12965 ENOG4105C0D helicase C2I25_12970 ENOG4105KBK Zinc finger, swim domain protein C2I25_12995 ENOG41069ER domain protein C2I25_13005 ENOG4105C94 Transporter C2I25_13015 ENOG4107R8N Glycosyl transferase, family 2 C2I25_13050 ENOG4105E0M Sulfatase C2I25_13065 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) C2I25_13075 ENOG4105DAA L-lactate C2I25_13130 ENOG4107RSM transcriptional regulator C2I25_13135 ENOG4105ECB domain protein C2I25_13155 ENOG4105VZJ PTS System C2I25_13165 ENOG4105VCP PTS System C2I25_13170 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) C2I25_13175 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) C2I25_13185 ENOG4105CK1 PTS System C2I25_13190 ENOG4105VCP PTS System C2I25_13195 ENOG4105F8D glycoside hydrolase family 4 C2I25_13215 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C2I25_13225 ENOG4105ESV Glycosyl transferase, family 4 C2I25_13230 ENOG4105C6Y Udp-glucose 6-dehydrogenase C2I25_13235 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase C2I25_13240 ENOG4108KGH TRANSCRIPTIONal C2I25_13245 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein C2I25_13260 ENOG4105KVH Transcriptional regulator C2I25_13275 ENOG41081UC Inherit from COG: Competence protein C2I25_13280 ENOG4105VEQ Cold shock protein C2I25_13285 ENOG4105MS2 ribosomal subunit Interface protein C2I25_13310 ENOG4105CAK Cell division ATP-binding protein ftsE C2I25_13315 ENOG4105CRP Part of the ABC transporter FtsEX involved in C2I25_13320 ENOG4105CN1 protease C2I25_13330 ENOG4105BZ1 (ABC) transporter C2I25_13340 ENOG4105C5H ABC transporter C2I25_13345 ENOG4108WS4 fmn reductase C2I25_13355 ENOG4105DUM transcriptional regulator, lysR family C2I25_13375 ENOG4107TXC Transcriptional regulator C2I25_13395 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) C2I25_13405 ENOG41086DT Membrane protein of unknown function C2I25_13425 ENOG4108S4C acetyltransferase C2I25_13435 ENOG4105C3M thioredoxin reductase C2I25_13445 ENOG4108Z4K mutator MutT protein C2I25_13450 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) C2I25_13455 ENOG4105CHW UPF0052 protein C2I25_13465 ENOG4105KRI phosphocarrier protein (HPr C2I25_13470 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) C2I25_13475 ENOG4108QY0 Membrane C2I25_13490 ENOG4105CZ3 stage V sporulation protein ad C2I25_13495 ENOG41090VF Stage v sporulation protein ac C2I25_13515 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C2I25_13565 ENOG41067MG lrgb family C2I25_13570 ENOG4105XZU Preprotein translocase, subunit SecG C2I25_13580 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) C2I25_13620 ENOG4105CM4 permease protein C2I25_13625 ENOG4108IPW abc transporter atp-binding protein C2I25_13660 ENOG4108W2Y isochorismatase C2I25_13670 ENOG4108VY7 phosphate-starvation-inducible protein PsiE C2I25_13675 ENOG4108MK9 spermidine N(1)-acetyltransferase C2I25_13690 ENOG4105WMR Protein CrcB homolog C2I25_13695 ENOG4105WMR Protein CrcB homolog C2I25_13715 ENOG4105D4A Cell wall formation (By similarity) C2I25_13720 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) C2I25_13735 ENOG4105KVH Transcriptional regulator C2I25_13740 ENOG4105F27 Major Facilitator C2I25_13745 ENOG4105CV8 reductase C2I25_13765 ENOG4108RYK Nad-dependent epimerase dehydratase C2I25_13780 ENOG4105D9N nucleoside C2I25_13785 ENOG4105D9N nucleoside C2I25_13790 ENOG4105DHF Membrane C2I25_13795 ENOG41090A1 ferritin C2I25_13805 ENOG4108URH decarboxylase C2I25_13820 ENOG4108RMU ferritin dps family protein C2I25_13835 ENOG4105NCW Trka-c domain protein C2I25_13840 ENOG4107S91 Sodium hydrogen exchanger C2I25_13845 ENOG4107T5V SNARE associated Golgi C2I25_13860 ENOG4105C2I pirin domain protein C2I25_13865 ENOG4105D4Y metalloprotease C2I25_13870 ENOG4105VG1 fes assembly suf system protein C2I25_13875 ENOG4105C8Q Methyl-accepting chemotaxis C2I25_13880 ENOG4105C8Q Methyl-accepting chemotaxis C2I25_13905 ENOG4105BZU Histidine kinase C2I25_13910 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C2I25_13915 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein C2I25_13925 ENOG4107ZTW SNARE associated Golgi C2I25_13970 ENOG4107AYK membrAne C2I25_13980 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins C2I25_13995 ENOG4107R7I amino acid C2I25_14000 ENOG4108SUT Major Facilitator Superfamily C2I25_14015 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer C2I25_14035 ENOG4105DZ1 carboxypeptidase C2I25_14050 ENOG4105CHU acetyl-coa acetyltransferase C2I25_14060 ENOG4105C1G acyl-Coa dehydrogenase C2I25_14065 ENOG4108W8B Beta-lactamase domain protein C2I25_14090 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) C2I25_14135 ENOG41080E8 Transcriptional regulator, Spx MgsR family C2I25_14165 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C2I25_14170 ENOG4108UMI ABC transporter, permease C2I25_14175 ENOG4105D01 (LipO)protein C2I25_14180 ENOG4105D01 (LipO)protein C2I25_14185 ENOG4105C3K feS assembly ATPase SufC C2I25_14190 ENOG4105JRK feS assembly protein SufD C2I25_14195 ENOG4105C9B Cysteine desulfurase C2I25_14200 ENOG4108UNV SUF system FeS assembly protein, NifU family C2I25_14205 ENOG4105DIW FeS assembly protein SUFB C2I25_14215 ENOG4107R8B 5'-nucleotidase C2I25_14220 ENOG4105KZD Domain of unknown function (DUF1805) C2I25_14225 ENOG4108YTE sporulation protein YunB C2I25_14230 ENOG4105FAA peptidase M23 C2I25_14255 ENOG41090T1 Membrane C2I25_14260 ENOG4107TXC Transcriptional regulator C2I25_14265 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) C2I25_14270 ENOG4105MMD transcriptional regulator C2I25_14290 ENOG4105CBT Fructose-1,6-bisphosphatase C2I25_14305 ENOG4105D4U had-superfamily hydrolase, subfamily iia C2I25_14310 ENOG4105DYS nad(p)h dehydrogenase (quinone) C2I25_14320 ENOG4105DAX Pfam:DUF2983 C2I25_14340 ENOG4108W5N phosphatidylglycerophosphatase a C2I25_14355 ENOG41083MR nifu domain-containing protein C2I25_14410 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA C2I25_14420 ENOG4105C4B ABC transporter, permease C2I25_14425 ENOG4108JJA ABC, transporter C2I25_14450 ENOG4108YX9 iron--sulfur cluster insertion protein erpA C2I25_14485 ENOG4105EWC Purine nucleoside phosphorylase C2I25_14515 ENOG4105CEP NADH dehydrogenase C2I25_14530 ENOG41069ER domain protein C2I25_14550 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase C2I25_14565 ENOG4105KA0 thioesterase Superfamily protein C2I25_14570 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) C2I25_14590 ENOG4107R3E Citrate transporter C2I25_14600 ENOG4105Y38 Kinase-associated protein B C2I25_14610 ENOG4105C87 Aminotransferase class I and II C2I25_14620 ENOG4108MUZ hydrolase C2I25_14625 ENOG4105C5I Dehydrogenase C2I25_14630 ENOG4108ZB6 transcriptional regulator AsnC family C2I25_14635 ENOG4105CHM Aminotransferase C2I25_14645 ENOG4105WG9 Conserved Protein C2I25_14665 ENOG4107PBV potassium channel C2I25_14670 ENOG4105KT7 mgtC SapB transporter C2I25_14815 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin C2I25_14825 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) C2I25_14830 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) C2I25_14875 ENOG4105VEQ Cold shock protein C2I25_14885 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase C2I25_14890 ENOG4105E4F Isochorismate synthase C2I25_14895 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) C2I25_14900 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) C2I25_14905 ENOG4108IPT Naphthoate synthase C2I25_14910 ENOG4105CEY Amp-dependent synthetase and ligase C2I25_14915 ENOG4105DTQ mandelate racemase muconate lactonizing C2I25_14935 ENOG41069H0 dihydroorotase EC 3.5.2.3 C2I25_14955 ENOG4105FDP GntR family transcriptional regulator C2I25_14960 ENOG4105C6Z Gluconate C2I25_15010 ENOG4105EMN RNA polymerase sigma factor C2I25_15025 ENOG41082BM Transcriptional regulator, arsr family C2I25_15040 ENOG41086D8 Transcriptional regulator C2I25_15045 ENOG4105C19 ABC transporter C2I25_15060 ENOG4107ZTW SNARE associated Golgi C2I25_15100 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) C2I25_15105 ENOG4108UGV hypoxanthine phosphoribosyltransferase C2I25_15130 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C2I25_15135 ENOG4105BZU Histidine kinase C2I25_15140 ENOG4105N67 Proton-coupled thiamine transporter YuaJ C2I25_15165 ENOG41087YS Phage shock protein A C2I25_15205 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii C2I25_15210 ENOG4105C4M (Ubiquinol oxidase) subunit I C2I25_15215 ENOG4108V2W Carbonate dehydratase C2I25_15235 ENOG410839T multidrug resistance protein C2I25_15240 ENOG41080TC multidrug resistance protein C2I25_15300 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component C2I25_15310 ENOG4105D2X ABC transporter substrate-binding protein C2I25_15325 ENOG4107T7U Sulfatase C2I25_15330 ENOG4107S9D Alpha beta hydrolase C2I25_15335 ENOG4105CH6 catalase C2I25_15340 ENOG4105BZU Histidine kinase C2I25_15345 ENOG4105BZU Histidine kinase C2I25_15430 ENOG4105EPU Molybdenum cofactor synthesis domain protein C2I25_15440 ENOG4105BZF Glycosyl transferase (Group 1 C2I25_15445 ENOG4105YVM Phosphoesterase, PA-phosphatase related C2I25_15450 ENOG4108Z0R Transferase C2I25_15455 ENOG4105E8V Alpha Beta Hydrolase Fold protein C2I25_15490 ENOG4105CIG ABC transporter C2I25_15505 ENOG4105N5T Radical SAM Protein C2I25_15525 ENOG4105C19 ABC transporter C2I25_15540 ENOG4105NCW Trka-c domain protein C2I25_15545 ENOG4107S91 Sodium hydrogen exchanger C2I25_15550 ENOG410605W Major Facilitator C2I25_15555 ENOG4105C8T Leucyl-tRNA synthetase C2I25_15580 ENOG4108B31 Spore germination protein C2I25_15590 ENOG4105DWV Homoserine O-trans-acetylase C2I25_15600 ENOG41085GJ domain protein C2I25_15625 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C2I25_15630 ENOG4105D06 uba thif-type nad fad binding protein C2I25_15640 ENOG4105CVM Molybdenum cofactor synthesis domain protein C2I25_15645 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein C2I25_15650 ENOG4108ZAF Molybdopterin C2I25_15665 ENOG4105CSC Glucose uptake protein C2I25_15670 ENOG4107EXU Short-chain dehydrogenase reductase Sdr C2I25_15675 ENOG4108VJ1 Transcriptional regulator (CarD family C2I25_15715 ENOG4105CBX hi0933 family C2I25_15730 ENOG4105YW5 deoR family transcriptional regulator C2I25_15735 ENOG4107QSE Dipeptidase C2I25_15745 ENOG4108IUM Glycogen debranching enzyme C2I25_15750 ENOG4108V15 phosphotransferase enzyme family C2I25_15765 ENOG4105C8F Beta-lactamase domain protein C2I25_15795 ENOG4108VDD TRNA binding domain protein C2I25_15830 ENOG4105K7K Transcriptional regulator C2I25_15840 ENOG4108IPJ Membrane C2I25_15855 ENOG4105C88 aminopeptidase C2I25_15875 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase C2I25_15885 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase C2I25_15895 ENOG4105ETE Transcriptional regulator (LacI family C2I25_15920 ENOG4105EP9 oxidoreductase C2I25_15925 ENOG4107SNB ankyrin repeat protein YahD C2I25_15930 ENOG4105BZU Histidine kinase C2I25_15935 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C2I25_15950 ENOG4105DGU Histone deacetylase C2I25_15955 ENOG4105W87 Cbs domain C2I25_15960 ENOG4105F1V Acetoin utilization protein C2I25_15980 ENOG4105EMN RNA polymerase sigma factor C2I25_16020 ENOG4105C28 cystathionine C2I25_16030 ENOG4105U5Y Transcriptional regulator C2I25_16040 ENOG4105RQF LysR family Transcriptional regulator C2I25_16065 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C2I25_16075 ENOG4105EFZ amidohydrolase C2I25_16095 ENOG4105KBJ sporulation protein ytfj C2I25_16100 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) C2I25_16110 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) C2I25_16130 ENOG4108JYZ YitT family C2I25_16170 ENOG4107YZX Universal stress protein C2I25_16190 ENOG41082W1 Cupin 2, conserved barrel domain protein C2I25_16195 ENOG4105Z7P Acetyltransferase (GNAT) family C2I25_16230 ENOG4105DC7 peptidase M24 C2I25_16260 ENOG4105SFS phosphoesterase RecJ domain protein C2I25_16270 ENOG4105VV2 C2I25_16275 ENOG4105C0B DNA polymerase III (alpha subunit) C2I25_16280 ENOG4105C6K Malic enzyme C2I25_16285 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family C2I25_16310 ENOG4105FS0 cytoplasmic membrane protein C2I25_16315 ENOG4108REF Sporulation integral membrane protein ytvi C2I25_16330 ENOG4105BZN citrate synthase C2I25_16335 ENOG4108HMX isocitrate dehydrogenase (NADP) C2I25_16360 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C2I25_16365 ENOG4105BZU Histidine kinase C2I25_16370 ENOG4105C2M dna polymerase I C2I25_16375 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) C2I25_16385 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) C2I25_16390 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase C2I25_16400 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) C2I25_16425 ENOG4108TDW sporulation protein YtxC C2I25_16430 ENOG4105C22 threonyL-tRNA synthetase C2I25_16435 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) C2I25_16455 ENOG4105CN9 Peptidase m42 family protein C2I25_16460 ENOG4108JGH Tetr family transcriptional regulator C2I25_16465 ENOG4105CW7 secretion protein, HlyD family C2I25_16470 ENOG4105C0R drug resistance transporter emrb qaca subfamily C2I25_16500 ENOG4108RWN rrna methyltransferase C2I25_16510 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) C2I25_16515 ENOG4105C5S asparaginyl-tRNA synthetase C2I25_16535 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C2I25_16550 ENOG4105DCG PHP domain protein C2I25_16565 ENOG4105FE9 pseudouridine synthase C2I25_16575 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) C2I25_16585 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) C2I25_16600 ENOG4105E0A ABC, transporter C2I25_16605 ENOG4105KFN sortase, SrtB family C2I25_16615 ENOG4105DR4 Methyltransferase C2I25_16630 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C2I25_16680 ENOG4105S6R Iron-hydroxamate transporter permease subunit C2I25_16685 ENOG4105J76 Periplasmic binding protein C2I25_16695 ENOG4105CEY Amp-dependent synthetase and ligase C2I25_16700 ENOG4107Z3H Transcriptional regulator, TetR family C2I25_16705 ENOG41060WC Enoyl-CoA hydratase C2I25_16710 ENOG4105BZJ Electron transfer flavoprotein C2I25_16715 ENOG4105C10 Electron transfer flavoprotein C2I25_16720 ENOG4105K63 Thioredoxin C2I25_16725 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) C2I25_16735 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit C2I25_16745 ENOG4105E33 succinate dehydrogenase C2I25_16755 ENOG4108VXD carboxy-peptidase C2I25_16765 ENOG4105E14 MotA TolQ exbB proton channel C2I25_16770 ENOG4105ER2 Ompa motb domain protein C2I25_16775 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family C2I25_16780 ENOG4108IUX (ABC) transporter C2I25_16785 ENOG4105RHA ABC transporter, permease C2I25_16790 ENOG4108Z40 Transcriptional regulator C2I25_16795 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) C2I25_16805 ENOG4108JCI Transcriptional regulator C2I25_16810 ENOG41067S9 phage shock protein C, PspC C2I25_16815 ENOG4105DZC cytosine deaminase C2I25_16825 ENOG4105PFC Transcriptional regulator C2I25_16835 ENOG4105KBX Transcriptional regulator, TetR family C2I25_16845 ENOG4108PCX Major Facilitator C2I25_16855 ENOG4108XJQ germination protein C2I25_16865 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) C2I25_16870 ENOG4105M59 Phosphodiesterase, mj0936 family C2I25_16900 ENOG4108QCI YvbH-like oligomerisation region C2I25_16925 ENOG4108IUQ atp-dependent protease C2I25_16945 ENOG4105K56 Transcriptional regulator C2I25_16970 ENOG4105D52 delta-aminolevulinic acid dehydratase C2I25_16980 ENOG41068KH stage VI sporulation protein D C2I25_16990 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) C2I25_16995 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase C2I25_17015 ENOG4105DFF Rod shape-determining protein mreb C2I25_17020 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) C2I25_17035 ENOG4107QMS site-determining protein C2I25_17050 ENOG4105C03 ribonuclease C2I25_17060 ENOG4105X36 (ribosomal) protein C2I25_17075 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control C2I25_17085 ENOG4105EWM Histidine kinase C2I25_17090 ENOG4105C19 ABC transporter C2I25_17105 ENOG4105CQC Prephenate dehydratase C2I25_17110 ENOG4108RPX mosc domain containing protein C2I25_17125 ENOG4108IYU L-aspartate oxidase C2I25_17130 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase C2I25_17160 ENOG4108HUF Transporter C2I25_17175 ENOG41061AI Protein of unknown function (DUF2905) C2I25_17190 ENOG4105VIE preprotein translocase, subunit YajC C2I25_17200 ENOG4108QG2 Membrane C2I25_17205 ENOG4105CKP Polysaccharide Biosynthesis Protein C2I25_17215 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C2I25_17220 ENOG41076HS cation diffusion facilitator family transporter C2I25_17225 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) C2I25_17235 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) C2I25_17250 ENOG4105CUT histidyl-tRNA synthetase C2I25_17260 ENOG4105CUZ uba thif-type nad fad binding protein C2I25_17275 ENOG4108VCI transcription factor, rsfa family C2I25_17280 ENOG4105D1H recombination factor protein RarA C2I25_17290 ENOG4105C3J Cysteine desulfurase C2I25_17295 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) C2I25_17305 ENOG4105C7H Helicase, RecD TraA family C2I25_17310 ENOG41060CR C2I25_17325 ENOG4105C02 permease C2I25_17335 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) C2I25_17355 ENOG4105HHA aminodeoxychorismate lyase C2I25_17360 ENOG4108VQJ O-methyltransferase C2I25_17365 ENOG4105XYU peptidase (U32 family) C2I25_17370 ENOG4105CFP Peptidase U32 C2I25_17380 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) C2I25_17385 ENOG4107XRG penicillin-binding protein C2I25_17415 ENOG4105C28 cystathionine C2I25_17420 ENOG4108EKI Dehydrogenase C2I25_17435 ENOG4108V5C ABC transporter C2I25_17440 ENOG4105S6R Iron-hydroxamate transporter permease subunit C2I25_17485 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase C2I25_17495 ENOG4105MIR Phenylalanine 4-monooxygenase C2I25_17500 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin C2I25_17535 ENOG4108MUZ hydrolase C2I25_17540 ENOG4105KEG ribosomal-protein-alanine acetyltransferase C2I25_17545 ENOG4105G6Z alkaline phosphatase C2I25_17560 ENOG4108TVJ Nitroreductase C2I25_17580 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C2I25_17595 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase C2I25_17600 ENOG4105CQW ribosome biogenesis GTPase YqeH C2I25_17610 ENOG410812S Rna-binding protein C2I25_17620 ENOG4108WF2 Metal Dependent Phosphohydrolase C2I25_17630 ENOG4105DXX methyltransferase C2I25_17640 ENOG4105KQC Competence protein C2I25_17645 ENOG4108UK2 deaminase C2I25_17650 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 C2I25_17660 ENOG4105TQK DNA polymerase iii, delta' subunit C2I25_17685 ENOG4105KVH Transcriptional regulator C2I25_17690 ENOG4105CSA Coproporphyrinogen iii oxidase C2I25_17720 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) C2I25_17725 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) C2I25_17740 ENOG4105KTH gatB Yqey C2I25_17750 ENOG41068P3 sporulation protein YqfC C2I25_17760 ENOG4105C9A Phoh family C2I25_17765 ENOG4105CTJ Metal Dependent Phosphohydrolase C2I25_17770 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) C2I25_17775 ENOG4107YR5 Diacylglycerol kinase C2I25_17780 ENOG4105KG3 cytidine deaminase C2I25_17785 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) C2I25_17820 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) C2I25_17825 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C2I25_17840 ENOG4105EGD dinuclear metal center protein, YbgI family C2I25_17865 ENOG41069ZM Protein of unknown function (DUF2624) C2I25_17870 ENOG4108JYZ YitT family C2I25_17875 ENOG4105FDK ABC transporter C2I25_17885 ENOG4105N80 Ferric uptake regulator, Fur family C2I25_17910 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C2I25_17920 ENOG4107RF6 penicillin-binding protein C2I25_17925 ENOG4105EXS phosphate abc transporter C2I25_17930 ENOG4105C8U phosphate abc transporter C2I25_17935 ENOG4105C8U phosphate abc transporter C2I25_17940 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) C2I25_17950 ENOG4108UTW Plays a role in the regulation of phosphate uptake C2I25_17965 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase C2I25_17975 ENOG4105DKQ ROK family C2I25_17985 ENOG4105C5X domain protein C2I25_18005 ENOG4105C28 cystathionine C2I25_18010 ENOG4105C28 cystathionine C2I25_18020 ENOG4105C3R Methionine synthase C2I25_18030 ENOG4105D7V transposase C2I25_18075 ENOG4107R6U sodium dicarboxylate symporter C2I25_18165 ENOG4105C0D helicase C2I25_18200 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family C2I25_18240 ENOG41080TC multidrug resistance protein C2I25_18265 ENOG4105WZW rhodanese family C2I25_18270 ENOG41082GG biotin lipoate A B protein ligase C2I25_18300 ENOG4107YBY Hydrolase C2I25_18310 ENOG4105CBJ Metal-dependent enzyme C2I25_18320 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) C2I25_18325 ENOG4105DC7 peptidase M24 C2I25_18350 ENOG4105CD2 stage iii sporulation protein aa C2I25_18355 ENOG4105KR5 Stage iii sporulation protein C2I25_18360 ENOG4108CQH stage III sporulation protein AC C2I25_18365 ENOG4105KQ4 Stage iii sporulation protein ad C2I25_18375 ENOG410644B Stage III sporulation protein af C2I25_18400 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C2I25_18405 ENOG4108ZSR alkaline shock protein C2I25_18415 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) C2I25_18430 ENOG4105CTB Polyprenyl synthetase C2I25_18440 ENOG4105DX0 Hemolysin A C2I25_18445 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) C2I25_18450 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) C2I25_18455 ENOG4105S1Z Stage IV sporulation protein B C2I25_18465 ENOG4107QQR Sporulation C2I25_18560 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C2I25_18570 ENOG4108JUB Transcriptional regulator C2I25_18585 ENOG4107RDP Dehydrogenase C2I25_18590 ENOG4105CKM Branched-chain carboxylic acid kinase C2I25_18605 ENOG4105CPP Dehydrogenase, E1 component C2I25_18610 ENOG4105C7S Dehydrogenase C2I25_18625 ENOG4108QY0 Membrane C2I25_18635 ENOG4105G7B Protein of unknown function (DUF2992) C2I25_18645 ENOG4108HW3 (ABC) transporter C2I25_18650 ENOG4105E5Q amino acid AbC transporter C2I25_18655 ENOG4105CDA abc transporter atp-binding protein C2I25_18660 ENOG4108QEG Membrane C2I25_18665 ENOG4108VZI ErfK ybiS ycfS ynhG family protein C2I25_18680 ENOG4105D9U N-acetyltransferase C2I25_18685 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) C2I25_18705 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic C2I25_18735 ENOG4105EJQ L-serine dehydratase C2I25_18740 ENOG4105II7 pyrroline-5-carboxylate reductase C2I25_18745 ENOG41069FQ Metallo-beta-lactamase superfamily C2I25_18750 ENOG4108IXY short-chain dehydrogenase reductase C2I25_18765 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) C2I25_18780 ENOG4105DBV ornithine carbamoyltransferase C2I25_18830 ENOG4105CGH 5'-nucleotidase C2I25_18835 ENOG4105DFD Na H antiporter C2I25_18850 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C2I25_18865 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) C2I25_18870 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) C2I25_18895 ENOG4108R6K riboflavin synthase, subunit alpha C2I25_18900 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) C2I25_18925 ENOG4108YM7 Gcn5-related n-acetyltransferase C2I25_18930 ENOG4105ETE Transcriptional regulator (LacI family C2I25_18940 ENOG4107SKW Inherit from COG: Alpha beta hydrolase C2I25_18960 ENOG4105RHY Pfam:UPF0157 C2I25_18965 ENOG4105CV8 reductase C2I25_18970 ENOG4105CPC Aldo Keto reductase C2I25_18990 ENOG4105MZ9 stage II sporulation protein m C2I25_18995 ENOG4105I3K Ferric uptake regulator, Fur family C2I25_19005 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C2I25_19030 ENOG4105D7N magnesium and cobalt transport protein CorA C2I25_19065 ENOG4105DVE abc transporter atp-binding protein C2I25_19070 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family C2I25_19080 ENOG4105DZ1 carboxypeptidase C2I25_19085 ENOG41082AN stage II sporulation protein C2I25_19095 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C2I25_19100 ENOG4105C8J )-transporter C2I25_19120 ENOG41090VF Stage v sporulation protein ac C2I25_19125 ENOG4105CZ3 stage V sporulation protein ad C2I25_19135 ENOG4105G6R Stage v sporulation protein ae C2I25_19145 ENOG4105J7I hydrolase C2I25_19150 ENOG4105PTM secreted protein C2I25_19155 ENOG4107ZE5 PPIases accelerate the folding of proteins C2I25_19195 ENOG4105CE4 GlcNAc 6-P deacetylase C2I25_19205 ENOG4105FDP GntR family transcriptional regulator C2I25_19215 ENOG4105CID antiterminator C2I25_19230 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) C2I25_19250 ENOG4105BZU Histidine kinase C2I25_19260 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C2I25_19275 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) C2I25_19300 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase C2I25_19320 ENOG4105DTD Dehydrogenase C2I25_19325 ENOG4105K7K Transcriptional regulator C2I25_19360 ENOG4105CHU acetyl-coa acetyltransferase C2I25_19405 ENOG4105CG3 alpha amylase, catalytic region C2I25_19415 ENOG4107FKK extracellular solute-binding protein family 1 C2I25_19425 ENOG4105EG2 ABC transporter, permease C2I25_19430 ENOG4105FKQ transcriptional regulator C2I25_19435 ENOG4105CHM Aminotransferase C2I25_19445 ENOG4108HGU Histidine kinase C2I25_19470 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) C2I25_19505 ENOG4105UIN C2I25_19515 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) C2I25_19530 ENOG4105K6S Short-chain dehydrogenase reductase Sdr C2I25_19535 ENOG4105EPM Diguanylate phosphodiesterase C2I25_19550 ENOG4107IN1 Protein of unknown function (DUF1797) C2I25_19560 ENOG4108XRC Protein of unknown function (DUF458) C2I25_19595 ENOG4107ZYR domain protein C2I25_19600 ENOG4105CN5 Metallo-Beta-Lactamase C2I25_19615 ENOG4108X4Q Hydrolase C2I25_19620 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) C2I25_19635 ENOG4105CPP Dehydrogenase, E1 component C2I25_19680 ENOG4105CXN decarboxylase C2I25_19700 ENOG4105ECY inositol monophosphatase C2I25_19710 ENOG4105CI3 gtp-binding protein typa C2I25_19715 ENOG4105QA2 C2I25_19735 ENOG4108IAB Phoh family C2I25_19750 ENOG4105CNI cell division protein FtsW C2I25_19760 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) C2I25_19810 ENOG4106UY4 Inherit from COG: Scp-like extracellular C2I25_19825 ENOG4107TB6 phosphoglycerate mutase C2I25_19845 ENOG4106H78 methyltransferase C2I25_19855 ENOG4105H20 Sporulation integral membrane protein YlbJ C2I25_19860 ENOG4105D78 K07001 NTE family protein C2I25_19865 ENOG41063PX domain protein C2I25_19875 ENOG4105KNH Nucleic acid-binding protein C2I25_19900 ENOG41074B2 UPF0747 protein C2I25_19915 ENOG4105CJN penicillin-binding protein C2I25_19920 ENOG4105CJN penicillin-binding protein C2I25_19925 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) C2I25_19940 ENOG4105CNI cell division protein FtsW C2I25_19945 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) C2I25_19950 ENOG4105D4A Cell wall formation (By similarity) C2I25_19960 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) C2I25_19965 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) C2I25_19975 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C2I25_19985 ENOG4105WR5 sporulation protein, YlmC YmxH family C2I25_19990 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase C2I25_19995 ENOG4105DFA alanine racemase domain protein C2I25_20005 ENOG41067XK integral membrane protein C2I25_20010 ENOG4105DBK s4 domain protein C2I25_20020 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) C2I25_20035 ENOG4105C34 Pseudouridine synthase C2I25_20070 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) C2I25_20120 ENOG4105DC7 peptidase M24 C2I25_20130 ENOG4105F23 Fibronectin-binding protein C2I25_20140 ENOG4105DSJ YicC domain protein C2I25_20160 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase C2I25_20165 ENOG4105C25 Primosomal protein n' C2I25_20180 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B C2I25_20190 ENOG4108ZF3 Phosphatase C2I25_20195 ENOG4105D9P serine threonine protein kinase C2I25_20200 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) C2I25_20205 ENOG4105DJV ribulose-phosphate 3-epimerase C2I25_20210 ENOG4105FJ0 thiamine C2I25_20225 ENOG4108ZAA Alkaline-shock protein C2I25_20230 ENOG4105DP4 dak2 domain fusion protein ylov C2I25_20235 ENOG4105CB5 ATP-dependent DNA helicase recG C2I25_20250 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase C2I25_20255 ENOG4105CHR reductase C2I25_20270 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) C2I25_20275 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) C2I25_20295 ENOG4105VB6 UPF0109 protein C2I25_20320 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) C2I25_20335 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha C2I25_20340 ENOG4105C79 DNA protecting protein DprA C2I25_20345 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) C2I25_20355 ENOG4108HE4 integrase family C2I25_20385 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) C2I25_20395 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) C2I25_20400 ENOG4105KNE Phosphatidate cytidylyltransferase C2I25_20405 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) C2I25_20410 ENOG4105DZP Membrane-associated zinc metalloprotease C2I25_20425 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) C2I25_20435 ENOG4105CHV Transcription elongation factor NusA C2I25_20440 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination C2I25_20445 ENOG4105VHM ribosomal protein C2I25_20455 ENOG4105W7A Protein of unknown function (DUF503) C2I25_20470 ENOG4105DTN riboflavin biosynthesis protein ribF C2I25_20490 ENOG4105C1V Peptidase, M16 C2I25_20500 ENOG4105E35 Dipicolinate synthase subunit A C2I25_20505 ENOG4108S0H Dipicolinic acid synthetase, b subunit C2I25_20510 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) C2I25_20520 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C2I25_20530 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit C2I25_20540 ENOG4105CNU cell division protein FtsK C2I25_20550 ENOG4105FDP GntR family transcriptional regulator C2I25_20555 ENOG4105DIH basic membrane C2I25_20560 ENOG4108JQ9 ABC transporter C2I25_20565 ENOG4105UIB (ABC) transporter C2I25_20585 ENOG4108RKS Short-chain dehydrogenase reductase Sdr C2I25_20590 ENOG4105XZV Protein of unknown function (DUF3243) C2I25_20605 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase C2I25_20630 ENOG4105D48 metallophosphoesterase C2I25_20635 ENOG4105MCT stage V sporulation protein S C2I25_20640 ENOG4108IGT Dipeptidase C2I25_20645 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein C2I25_20650 ENOG4105DQU oxidoreductase, subunit beta C2I25_20685 ENOG410890F Dynamin family C2I25_20690 ENOG4105E0M Sulfatase C2I25_20705 ENOG4105F0V Cell wall hydrolase C2I25_20715 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C C2I25_20720 ENOG4105CS2 ec 3.2.1.21 C2I25_20725 ENOG4108S3Y transcriptional regulator C2I25_20745 ENOG41067MG lrgb family C2I25_20785 ENOG4105BZU Histidine kinase C2I25_20815 ENOG4105D03 DNA-3-methyladenine glycosylase II C2I25_20820 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C2I25_20830 ENOG4105CGK Exodeoxyribonuclease III C2I25_20850 ENOG4105E0A ABC, transporter C2I25_20855 ENOG4105NIV Esterase C2I25_20865 ENOG4105VPX protein, conserved in bacteria C2I25_20870 ENOG410681U heavy metal transport detoxification protein C2I25_20875 ENOG4105C59 p-type ATPase C2I25_20885 ENOG4105K70 DNA-binding protein C2I25_20890 ENOG4105TMB Formate nitrite transporter C2I25_20910 ENOG4105C85 amino acid C2I25_20925 ENOG4108SJC Membrane C2I25_20930 ENOG4107QW4 alcohol dehydrogenase C2I25_20935 ENOG4105E98 transcriptional regulator DeoR family C2I25_20940 ENOG4105DE4 1-phosphofructokinase C2I25_20945 ENOG4105DM4 PTS System C2I25_20955 ENOG41069ER domain protein C2I25_20985 ENOG4106F1P AAA ATPase, central domain protein C2I25_20990 ENOG4105EN6 Membrane C2I25_20995 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) C2I25_21000 ENOG4105CXI aluminum resistance protein C2I25_21005 ENOG4105KV4 Transcriptional regulator C2I25_21010 ENOG4105C5F glutamine synthetase C2I25_21015 ENOG4105K7K Transcriptional regulator C2I25_21035 ENOG4108SVB resolvase C2I25_21045 ENOG4105CGH 5'-nucleotidase C2I25_21085 ENOG4105BZ1 (ABC) transporter C2I25_21090 ENOG4105BZ1 (ABC) transporter C2I25_21130 ENOG41067MG lrgb family C2I25_21135 ENOG4105VAW lrga family C2I25_21140 ENOG4107RSM transcriptional regulator C2I25_21155 ENOG4105CJ1 ABC, transporter C2I25_21165 ENOG4105CH2 amidohydrolase C2I25_21180 ENOG4107QIV Cytochrome c biogenesis protein C2I25_21215 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) C2I25_21240 ENOG4108903 Formimidoylglutamase C2I25_21245 ENOG4108VJ1 Transcriptional regulator (CarD family C2I25_21250 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C2I25_21255 ENOG4105CBC glutamate synthase C2I25_21260 ENOG4105CK7 Sodium proline symporter C2I25_21265 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase C2I25_21270 ENOG4105FBA Phospholipase Carboxylesterase C2I25_21275 ENOG4105BZU Histidine kinase C2I25_21290 ENOG4107AYK membrAne C2I25_21375 ENOG4105CJ1 ABC, transporter C2I25_21390 ENOG4105C19 ABC transporter C2I25_21405 ENOG4105BZU Histidine kinase C2I25_21415 ENOG4105CEY Amp-dependent synthetase and ligase C2I25_21420 ENOG4107ZYJ bioY protein C2I25_21425 ENOG4107F3J Amp-dependent synthetase and ligase C2I25_21445 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) C2I25_21455 ENOG4105E5W Transporter C2I25_21485 ENOG4108I0Z Aconitate hydratase C2I25_21490 ENOG4108JJA ABC, transporter C2I25_21500 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C2I25_21505 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) C2I25_21530 ENOG4105W8X HesB YadR YfhF-family protein C2I25_21535 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) C2I25_21540 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase C2I25_21550 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C2I25_21555 ENOG4105C0H protease C2I25_21560 ENOG4105K4P CoA-binding domain protein C2I25_21570 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C2I25_21580 ENOG4105D9R oxidoreductase C2I25_21600 ENOG4105CIG ABC transporter C2I25_21610 ENOG4105EMN RNA polymerase sigma factor C2I25_21620 ENOG4108KGH TRANSCRIPTIONal C2I25_21685 ENOG4105CUB amino acid C2I25_21700 ENOG4105E1K spore germination protein C2I25_21710 ENOG4108JB9 formate dehydrogenase C2I25_21720 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) C2I25_21725 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) C2I25_21740 ENOG4105TMB Formate nitrite transporter C2I25_21745 ENOG4105D06 uba thif-type nad fad binding protein C2I25_21750 ENOG4105CVM Molybdenum cofactor synthesis domain protein C2I25_21755 ENOG4108ZAF Molybdopterin C2I25_21765 ENOG4105D1F ATP-binding protein C2I25_21780 ENOG410696E Membrane C2I25_21785 ENOG4105FR1 rard protein C2I25_21795 ENOG4105EWU Squalene--hopene cyclase C2I25_21805 ENOG4105CHR reductase C2I25_21810 ENOG4105C26 Dehydrogenase C2I25_21820 ENOG4108IA2 Sodium pantothenate symporter C2I25_21835 ENOG4106IQC argininosuccinate lyase C2I25_21845 ENOG410904N short-chain dehydrogenase reductase C2I25_21865 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) C2I25_21885 ENOG4105VEQ Cold shock protein C2I25_21900 ENOG4108R1P C2I25_21910 ENOG41073R8 VanW family C2I25_21915 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase C2I25_21925 ENOG4105KT7 mgtC SapB transporter C2I25_21935 ENOG4105BZU Histidine kinase C2I25_21955 ENOG4107DUR UPF0457 protein C2I25_21960 ENOG4108VXD carboxy-peptidase C2I25_21970 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity C2I25_21975 ENOG41067SE Tetr family transcriptional regulator C2I25_22025 ENOG4105D7V transposase C2I25_22030 ENOG4105FAW cDP-glucose 4,6-dehydratase C2I25_22035 ENOG4108IAJ Nad-dependent epimerase dehydratase C2I25_22045 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase C2I25_22065 ENOG4105E1K spore germination protein C2I25_22080 ENOG4108M1A Chitin-binding protein C2I25_22085 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C C2I25_22125 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C2I25_22140 ENOG4105CEP NADH dehydrogenase C2I25_22145 ENOG4107TPS domain protein C2I25_22160 ENOG4105CQB FAD linked oxidase domain protein C2I25_22195 ENOG4105CNG UPF0061 protein C2I25_22200 ENOG4105CB2 alcohol dehydrogenase C2I25_22205 ENOG41082BM Transcriptional regulator, arsr family C2I25_22215 ENOG4107VXM glycerophosphoryl diester phosphodiesterase C2I25_22240 ENOG4108A04 Beta-lactamase C2I25_22255 ENOG4105FFC UPF0187 protein C2I25_22275 ENOG4105DPN Oligoendopeptidase f C2I25_22280 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase C2I25_22285 ENOG4105E5K Alpha-amylase C2I25_22295 ENOG4105C98 muts2 protein C2I25_22315 ENOG4107V2S Transcriptional regulator C2I25_22330 ENOG4107CUJ Protein of unknown function (DUF2690) C2I25_22350 ENOG4105NX3 Membrane C2I25_22355 ENOG4105DQ5 transport system permease protein C2I25_22360 ENOG4105EHG Permease protein C2I25_22365 ENOG4108MES Periplasmic binding protein C2I25_22380 ENOG4107R3E Citrate transporter C2I25_22390 ENOG4108TN2 lmbE family C2I25_22470 ENOG4105H3G oxidoreductase C2I25_22515 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) C2I25_22590 ENOG4108ZJ4 polysaccharide deacetylase C2I25_22605 ENOG4105KVH Transcriptional regulator C2I25_22610 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein C2I25_22630 ENOG4105CAQ asparagine synthetase C2I25_22705 ENOG4105KVH Transcriptional regulator C2I25_22710 ENOG4105KVH Transcriptional regulator C2I25_22715 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase C2I25_22720 ENOG4105D9R oxidoreductase C2I25_22725 ENOG4108TZY GntR Family Transcriptional Regulator C2I25_22730 ENOG4105KVH Transcriptional regulator C2I25_22770 ENOG4105C44 Serine transporter C2I25_22785 ENOG4105CHH sulfate transporter C2I25_22790 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA C2I25_22825 ENOG4105F27 Major Facilitator C2I25_22830 ENOG4105CV8 reductase C2I25_22845 ENOG4105KVH Transcriptional regulator C2I25_22850 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) C2I25_22855 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) C2I25_22860 ENOG4108UX3 '-nucleotidase C2I25_22880 ENOG4105EWI Short-chain dehydrogenase reductase Sdr C2I25_22895 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone C2I25_22900 ENOG4105CIS alcohol dehydrogenase C2I25_22905 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase C2I25_22910 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase C2I25_22915 ENOG4105CV1 Transketolase (EC 2.2.1.1) C2I25_22930 ENOG4105C6Z Gluconate C2I25_22935 ENOG4105CMG Carbohydrate kinase C2I25_22940 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) C2I25_22945 ENOG4105XDF Protein of unknown function (DUF1272) C2I25_22950 ENOG4105DDN Pentapeptide repeat-containing protein C2I25_22980 ENOG4105FAW cDP-glucose 4,6-dehydratase C2I25_22985 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase C2I25_23000 ENOG4105C37 (CBS) domain C2I25_23030 ENOG4105EV4 Multidrug resistance protein mdtH C2I25_23040 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) C2I25_23075 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) C2I25_23085 ENOG4108UW5 maltose o-acetyltransferase C2I25_23090 ENOG4106UW1 Major Facilitator superfamily C2I25_23095 ENOG4105DKQ ROK family C2I25_23100 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase C2I25_23175 ENOG4108PSK reductase C2I25_23205 ENOG4108RCM Nitroreductase C2I25_23210 ENOG4105KVH Transcriptional regulator C2I25_23230 ENOG4108Z66 YbaK ebsC protein C2I25_23250 ENOG4108K8S endonuclease I C2I25_23310 ENOG4105DYS nad(p)h dehydrogenase (quinone) C2I25_23320 ENOG4105CRW Short chain fatty acid transporter C2I25_23335 ENOG41069JR C2I25_23340 ENOG4105DA5 (ABC) transporter C2I25_23355 ENOG4105CZM Major Facilitator C2I25_23360 ENOG4107MII Sugar-specific transcriptional regulator TrmB C2I25_23375 ENOG4108ISG Major Facilitator C2I25_23385 ENOG4105PNM synthesis protein C2I25_23390 ENOG4108VXD carboxy-peptidase C2I25_23410 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase C2I25_23435 ENOG410874W AraC family transcriptional regulator C2I25_23445 ENOG41082W1 Cupin 2, conserved barrel domain protein C2I25_23460 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) C2I25_23465 ENOG4108JQ1 Dehydrogenase C2I25_23485 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A C2I25_23500 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C2I25_23505 ENOG4105BZU Histidine kinase C2I25_23510 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) C2I25_23520 ENOG4105BZU Histidine kinase C2I25_23540 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) C2I25_23560 ENOG4105JQZ Methyltransferase C2I25_23570 ENOG4105E0Y RtcB Protein C2I25_23580 ENOG4105C88 aminopeptidase C2I25_23595 ENOG4105K6H D-cysteine desulfhydrase C2I25_23620 ENOG4105C0R drug resistance transporter emrb qaca subfamily C2I25_23625 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) C2I25_23665 ENOG4105C19 ABC transporter C2I25_23705 ENOG41062D9 Histidine kinase C2I25_23710 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C2I25_23740 ENOG4105N0V mono-oxygenase ydhR C2I25_23750 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family C2I25_23755 ENOG4105CZV ABC transporter C2I25_23785 ENOG4105DWP Membrane C2I25_23790 ENOG4105DUM transcriptional regulator, lysR family C2I25_23795 ENOG4105C44 Serine transporter C2I25_23845 ENOG4108YXU transcriptional regulator AsnC family C2I25_23850 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C2I25_23855 ENOG4105M4P Tetr family transcriptional regulator C2I25_23860 ENOG4105F27 Major Facilitator C2I25_23865 ENOG4108IG5 Transcriptional regulator C2I25_23870 ENOG4107P5I polyketide synthase C2I25_23900 ENOG41085FC arsR family transcriptional regulator C2I25_23905 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase C2I25_23910 ENOG4105D6J arsenicaL-resistance protein C2I25_23915 ENOG4108SY2 LMWPc C2I25_23920 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase C2I25_23925 ENOG4105KY5 gCN5-related N-acetyltransferase C2I25_23930 ENOG4107VMI polysaccharide deacetylase C2I25_23940 ENOG4105GPN Uncharacterized conserved protein (DUF2294) C2I25_23945 ENOG4108TWJ NADH dehydrogenase subunit 5 C2I25_23960 ENOG4105CVP deoxyribo-dipyrimidine photolyase C2I25_23965 ENOG4108606 TspO/MBR family C2I25_24030 ENOG41090MY MarR family Transcriptional regulator C2I25_24055 ENOG4105CHJ isochorismatase hydrolase C2I25_24065 ENOG4105CGH 5'-nucleotidase C2I25_24085 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C2I25_24095 ENOG4105CN5 Metallo-Beta-Lactamase C2I25_24105 ENOG4105E2A Dehydrogenase C2I25_24130 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) C2I25_24175 ENOG4105DWD nucleoside recognition domain protein C2I25_24190 ENOG4105FDT acyl-CoA dehydrogenase C2I25_24200 ENOG4108ZHR arsR family transcriptional regulator C2I25_24205 ENOG4106N3A copper homeostasis protein cutc C2I25_24215 ENOG4107258 Transcriptional regulator C2I25_24220 ENOG4105P4J Allophanate hydrolase, subunit 1 C2I25_24230 ENOG4105E7W lamb ycsf family protein C2I25_24250 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) C2I25_24255 ENOG4107RF6 penicillin-binding protein C2I25_24290 ENOG4105F1N DNA alkylation repair C2I25_24300 ENOG4108IQI permease C2I25_24310 ENOG410635A Membrane C2I25_24330 ENOG4105RHY Pfam:UPF0157 C2I25_24355 ENOG4108PCN EamA-like transporter family C2I25_24370 ENOG4108XET gCN5-related N-acetyltransferase C2I25_24375 ENOG4108DMH HTH_ARAC C2I25_24390 ENOG4105CMR udp-glucose 4-epimerase C2I25_24395 ENOG4105WEC Molybdate metabolism regulator C2I25_24400 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) C2I25_24420 ENOG4105FS7 Transcriptional regulator C2I25_24425 ENOG4108TVJ Nitroreductase C2I25_24465 ENOG4105C8Y Acetylornithine aminotransferase C2I25_24485 ENOG4105C7R Atpase associated with various cellular activities aaa_3 C2I25_24515 ENOG41068WN C2I25_24525 ENOG4108WCX response regulator C2I25_24535 ENOG41090T1 Membrane C2I25_24555 ENOG4105VMP Transcriptional regulator C2I25_24565 ENOG4105G6Z alkaline phosphatase C2I25_24570 ENOG4107RBI VanW family C2I25_24580 ENOG4105ECK Fatty Acid Desaturase C2I25_24610 ENOG4107258 Transcriptional regulator C2I25_24620 ENOG4105II7 pyrroline-5-carboxylate reductase C2I25_24655 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) C2I25_24670 ENOG41061GT Aldolase C2I25_24680 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) C2I25_24685 ENOG4105DKT Transcriptional regulator C2I25_24695 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane C2I25_24700 ENOG4105F5R ABC transporter C2I25_24705 ENOG4105D4B ABC, transporter C2I25_24730 ENOG4105DNP FAD linked oxidase domain protein C2I25_24745 ENOG41069ER domain protein C2I25_24795 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase C2I25_24805 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase C2I25_24830 ENOG41082JN Transcriptional regulator C2I25_24835 ENOG4105EYF MMPL domain protein C2I25_24840 ENOG4105C5H ABC transporter C2I25_24845 ENOG4105E0M Sulfatase C2I25_24850 ENOG4108ZCF integral membrane protein C2I25_24860 ENOG4107VMI polysaccharide deacetylase C2I25_24875 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase C2I25_24880 ENOG4105C6T cysteine synthase C2I25_24885 ENOG4107VC0 DNA alkylation repair enzyme C2I25_24925 ENOG4108AQF aminoglycoside N(3)-acetyltransferase C2I25_24960 ENOG4105D7T ABC transporter C2I25_24965 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein C2I25_24970 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component C2I25_24975 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) C2I25_24990 ENOG4105C02 permease C2I25_25045 ENOG4105DVE abc transporter atp-binding protein C2I25_25065 ENOG4108ZMI UPF0477 protein C2I25_25080 ENOG4105CHM Aminotransferase C2I25_25120 ENOG41089UC methyltransferase, type 11 C2I25_25135 ENOG4107BMA Transglycosylase associated protein C2I25_25160 ENOG4106K7D Major facilitator family transporter C2I25_25165 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) C2I25_25230 ENOG4105EPR degv family C2I25_25235 ENOG4105DPN Oligoendopeptidase f C2I25_25255 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 C2I25_25270 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C2I25_25275 ENOG4105BZU Histidine kinase C2I25_25280 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) C2I25_25285 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) C2I25_25320 ENOG4107SET aldo keto reductase C2I25_25335 ENOG4105DTQ mandelate racemase muconate lactonizing C2I25_25350 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD C2I25_25360 ENOG4107T5V SNARE associated Golgi C2I25_25395 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein C2I25_25405 ENOG41080HI glycine oxidase C2I25_25410 ENOG4105CTU Proline racemase C2I25_25415 ENOG4105CTU Proline racemase C2I25_25420 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C2I25_25425 ENOG4105C26 Dehydrogenase C2I25_25430 ENOG4105BZG amino acid carrier protein C2I25_25450 ENOG4108M1A Chitin-binding protein C2I25_25510 ENOG4105C9U ATP-dependent DNA helicase RecQ C2I25_25530 ENOG4105EEM helicase C2I25_25555 ENOG4108Z7F N-acetyltransferase C2I25_25575 ENOG4105MSB protein, conserved in bacteria C2I25_25600 ENOG41087PP glycosyltransferase MGT family C2I25_25605 ENOG4108M1A Chitin-binding protein C2I25_25610 ENOG41082BV acetyltransferase C2I25_25615 ENOG4105E66 phosphoriboisomerase A C2I25_25630 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) C2I25_25640 ENOG4108IJ7 Glycine betaine C2I25_25645 ENOG4107SQ8 Glycine betaine C2I25_25685 ENOG4105RHY Pfam:UPF0157 C2I25_25690 ENOG4105E1F short-chain dehydrogenase reductase C2I25_25700 ENOG4107RUY (E1 component), alpha subunit C2I25_25710 ENOG4107QKR Dehydrogenase C2I25_25730 ENOG41062ES Transcriptional regulator C2I25_25745 ENOG4105E98 transcriptional regulator DeoR family C2I25_25765 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family C2I25_25795 ENOG4107Z3H Transcriptional regulator, TetR family C2I25_25800 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) C2I25_25805 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) C2I25_25835 ENOG4105MSI germination protein ypeb C2I25_25880 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) C2I25_25885 ENOG4105CIS alcohol dehydrogenase C2I25_25890 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C2I25_25895 ENOG4105FDR Membrane C2I25_25900 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) C2I25_25915 ENOG4105CGH 5'-nucleotidase C2I25_25925 ENOG4108IUM Glycogen debranching enzyme C2I25_25950 ENOG4107WD8 ABC transporter, permease C2I25_25970 ENOG4105BZU Histidine kinase C2I25_25975 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C2I25_25980 ENOG4105U0R haloacid dehalogenase-like hydrolase C2I25_26005 ENOG4107VFR oxidoreductase C2I25_26045 ENOG4105PKS Excinuclease abc c subunit domain protein C2I25_26080 ENOG4105KWG Pfam:DUF1696 C2I25_26085 ENOG4108NRW Phospholipase, patatin family C2I25_26110 ENOG4108XI2 Domain of unknown function (DUF1963) C2I25_26115 ENOG4105KME endoribonuclease L-psp C2I25_26140 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) C2I25_26145 ENOG4105E09 nadh pyrophosphatase C2I25_26160 ENOG4105FCD Major Facilitator C2I25_26205 ENOG4107Y9U Membrane C2I25_26230 ENOG4107VXM glycerophosphoryl diester phosphodiesterase C2I25_26255 ENOG4108Z5V transcriptional regulator, merr family C2I25_26260 ENOG4107Y80 Major Facilitator superfamily C2I25_26310 ENOG4105CJN penicillin-binding protein C2I25_26315 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase C2I25_26320 ENOG4105CB2 alcohol dehydrogenase C2I25_26385 ENOG4108HGU Histidine kinase C2I25_26400 ENOG4108JJB ABC transporter C2I25_26425 ENOG4107RF6 penicillin-binding protein C2I25_26430 ENOG4105BZU Histidine kinase C2I25_26435 ENOG410667J hydrolase C2I25_26535 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase C2I25_26540 ENOG4105XSJ toxin secretion phage lysis holin C2I25_26595 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) C2I25_26705 ENOG4105KRN Transcriptional regulator, abrb family C2I25_26745 ENOG4105VTR Integrase C2I25_26775 ENOG4105ETU transcriptional activator (TenA C2I25_26780 ENOG4105CPF Cell wall formation (By similarity) C2I25_26790 ENOG4105D6E homoserine dehydrogenase C2I25_26865 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) C2I25_26870 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) C2I25_26875 ENOG410900G Protein of unknown function (DUF421) C2I25_26895 ENOG4105EFA 4-hydroxyphenylacetate C2I25_26950 ENOG4105KVH Transcriptional regulator C2I25_26955 ENOG41061TZ Short-chain dehydrogenase reductase Sdr C2I25_26980 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) C2I25_27010 ENOG41075H3 AraC family transcriptional regulator C2I25_27035 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) C2I25_27050 ENOG4105T9C HD domain C2I25_27065 ENOG4105DZ1 carboxypeptidase C2I25_27085 ENOG4105DBI uridine monophosphokinase C2I25_27105 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C2I25_27110 ENOG4107QX3 carboxylase C2I25_27115 ENOG4105E39 Enoyl-CoA hydratase C2I25_27120 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase C2I25_27125 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit C2I25_27130 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C2I25_27135 ENOG4105C1G acyl-Coa dehydrogenase C2I25_27150 ENOG4107Z3H Transcriptional regulator, TetR family C2I25_27160 ENOG4105CJ1 ABC, transporter C2I25_27170 ENOG4105DIN metallophosphoesterase C2I25_27190 ENOG4107RF6 penicillin-binding protein C2I25_27195 ENOG4107RF6 penicillin-binding protein C2I25_27210 ENOG4107RVG penicillin-binding protein C2I25_27265 ENOG4107S9D Alpha beta hydrolase C2I25_27275 ENOG4105BZU Histidine kinase C2I25_27300 ENOG41075H3 AraC family transcriptional regulator C2I25_27320 ENOG4105YWU small acid-soluble spore protein C2I25_27325 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) C2I25_27330 ENOG4105CUB amino acid C2I25_27335 ENOG4105II7 pyrroline-5-carboxylate reductase C2I25_27340 ENOG4108NHD germination protein C2I25_27345 ENOG4108Q8B Spore germination protein C2I25_27400 ENOG4105W8Z 4'-phosphopantetheinyl transferase C2I25_27440 ENOG4105EQK -acetyltransferase C2I25_27445 ENOG4105EJ9 Membrane C2I25_27455 ENOG4105KRN Transcriptional regulator, abrb family C2I25_27490 ENOG4105CIN aminoacyl-histidine dipeptidase C2I25_27540 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) C2I25_27545 ENOG4105K56 Transcriptional regulator C2I25_27550 ENOG4107RA9 decarboxylase C2I25_27565 ENOG41088CC tellurite resistance protein tehB C2I25_27605 ENOG4105KRN Transcriptional regulator, abrb family C2I25_27625 ENOG4105VTR Integrase C2I25_27650 ENOG4108RZE Tetr family transcriptional regulator C2I25_27660 ENOG4105C1J atp-dependent rna helicase C2I25_27675 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) C2I25_27690 ENOG4108INS Transcriptional regulator C2I25_27695 ENOG4105C7B Threonine dehydratase C2I25_27705 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) C2I25_27710 ENOG4105RD7 BadF BadG BcrA BcrD C2I25_27715 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) C2I25_27735 ENOG4105F32 YngK protein C2I25_27765 ENOG4108KPJ rna polymerase sigma factor C2I25_27770 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) C2I25_27805 ENOG4108JCI Transcriptional regulator C2I25_27840 ENOG4105BZ1 (ABC) transporter C2I25_27845 ENOG4105BZ1 (ABC) transporter C2I25_27860 ENOG4108RPX mosc domain containing protein C2I25_27865 ENOG4105DND Transcriptional regulator C2I25_27885 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) C2I25_27890 ENOG4107V2S Transcriptional regulator C2I25_27900 ENOG4108KP7 hydrolase C2I25_27925 ENOG41068WN C2I25_27935 ENOG4105C1Q protoporphyrinogen oxidase C2I25_27960 ENOG4105WCN acetyltransferase C2I25_27985 ENOG4105EYF MMPL domain protein C2I25_28010 ENOG4108Y4K DNA-binding transcriptional activator C2I25_28020 ENOG41081I9 integral membrane protein C2I25_28075 ENOG4105C19 ABC transporter C2I25_28080 ENOG4105C22 threonyL-tRNA synthetase C2I25_28085 ENOG4105FE9 pseudouridine synthase C2I25_28105 ENOG4105BZG amino acid carrier protein C2I25_28125 ENOG4105K70 DNA-binding protein C2I25_28140 ENOG4105C0R drug resistance transporter emrb qaca subfamily C2I25_28145 ENOG4105WQT MbtH domain protein C2I25_28150 ENOG4105CEY Amp-dependent synthetase and ligase C2I25_28155 ENOG4105WQI isochorismatase C2I25_28160 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase C2I25_28165 ENOG4105E4F Isochorismate synthase C2I25_28170 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase C2I25_28180 ENOG4105FCD Major Facilitator C2I25_28205 ENOG4105EYH Exonuclease C2I25_28210 ENOG4107RFY SbcCD D subunit C2I25_28225 ENOG4105E39 Enoyl-CoA hydratase C2I25_28230 ENOG4105N14 lysine exporter protein LysE YggA C2I25_28240 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C2I25_28245 ENOG4105C1G acyl-Coa dehydrogenase C2I25_28250 ENOG4105CR4 methylisocitrate lyase C2I25_28255 ENOG4105DXD 2-methylcitrate dehydratase C2I25_28265 ENOG4105W8X HesB YadR YfhF-family protein C2I25_28270 ENOG4105CZM Major Facilitator C2I25_28280 ENOG4105BZ4 penicillin-binding protein C2I25_28335 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) C2I25_28385 ENOG4105KNA -acetyltransferase C2I25_28390 ENOG4105SZ6 Thioredoxin C2I25_28400 ENOG410841Q phosphoesterase PA-phosphatase related protein C2I25_28445 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein C2I25_28450 ENOG4108JUB Transcriptional regulator C2I25_28455 ENOG4108TSC N-acetyltransferase C2I25_28460 ENOG4107S4Y M20 DapE family protein YgeY C2I25_28475 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C2I25_28500 ENOG4105C37 (CBS) domain C2I25_28545 ENOG4105C37 (CBS) domain C2I25_28580 ENOG4105E90 ABC transporter