locus-tag	class	description
C2I25_00015	COG5506	Protein of unknown function (DUF1694)
C2I25_00020	COG1012	belongs to the aldehyde dehydrogenase family
C2I25_00025	COG1253	flavin adenine dinucleotide binding
C2I25_00060	COG1732	Glycine betaine
C2I25_00105	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C2I25_00130	COG1064	alcohol dehydrogenase
C2I25_00135	COG0384	phenazine biosynthesis protein PhzF
C2I25_00140	COG1737	Transcriptional regulator
C2I25_00145	COG2197	response regulator
C2I25_00150	COG4585	Histidine kinase
C2I25_00150	COG2203	Gaf domain
C2I25_00155	COG0668	transmembrane transport
C2I25_00160	COG1335	isochorismatase
C2I25_00180	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2I25_00185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2I25_00190	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2I25_00205	COG0367	asparagine synthase
C2I25_00210	COG0071	Belongs to the small heat shock protein (HSP20) family
C2I25_00215	COG1999	signal sequence binding
C2I25_00225	COG1307	EDD domain protein, DegV family
C2I25_00240	COG0805	protein transport
C2I25_00250	COG1272	protein, Hemolysin III
C2I25_00255	COG0204	Acyl-transferase
C2I25_00265	COG0768	penicillin binding
C2I25_00280	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2I25_00295	COG0546	phosphoglycolate phosphatase activity
C2I25_00305	COG4473	ABC transporter
C2I25_00310	COG1131	(ABC) transporter
C2I25_00320	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C2I25_00325	COG3655	Transcriptional regulator
C2I25_00335	COG0456	acetyltransferase
C2I25_00345	COG1794	racemase activity, acting on amino acids and derivatives
C2I25_00355	COG2610	gluconate transmembrane transporter activity
C2I25_00380	COG0733	neurotransmitter:sodium symporter activity
C2I25_00405	COG5444	nuclease activity
C2I25_00435	COG1674	ftsk spoiiie
C2I25_00455	COG0017	Asparaginyl-tRNA synthetase
C2I25_00500	COG0018	arginyl-trna synthetase
C2I25_00505	COG2521	methyltransferase
C2I25_00505	COG2136	Putative SAM-dependent methyltransferase
C2I25_00520	COG1413	lyase activity
C2I25_00530	COG0629	single-stranded DNA binding
C2I25_00545	COG0488	(ABC) transporter
C2I25_00550	COG1418	mRNA catabolic process
C2I25_00595	COG0457	Tetratricopeptide repeat
C2I25_00680	COG3547	Transposase (IS116 IS110 IS902 family)
C2I25_00725	COG4653	Phage capsid family
C2I25_00730	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C2I25_00745	COG1783	phage Terminase large subunit
C2I25_00750	COG5484	DNA packaging
C2I25_00760	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2I25_00800	COG0662	Cupin 2, conserved barrel domain protein
C2I25_00805	COG0582	viral genome integration into host DNA
C2I25_00880	COG1396	sequence-specific DNA binding
C2I25_00885	COG0515	serine threonine protein kinase
C2I25_00885	COG2815	serine threonine protein kinase
C2I25_00900	COG2856	Zn peptidase
C2I25_00925	COG2359	stage V sporulation protein S
C2I25_00960	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
C2I25_00965	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2I25_00970	COG2146	nitrite reductase [NAD(P)H] activity
C2I25_00975	COG1587	Uroporphyrinogen-III synthase
C2I25_00975	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2I25_00985	COG1648	precorrin-2 dehydrogenase activity
C2I25_01005	COG2223	nitrite transmembrane transporter activity
C2I25_01015	COG0314	molybdopterin synthase activity
C2I25_01020	COG0303	'Molybdopterin
C2I25_01025	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2I25_01030	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2I25_01035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2I25_01040	COG2181	nitrate reductase activity
C2I25_01045	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C2I25_01050	COG1140	nitrate reductase beta subunit
C2I25_01055	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C2I25_01060	COG0714	Associated with various cellular activities
C2I25_01065	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
C2I25_01070	COG1305	Transglutaminase-like
C2I25_01075	COG0386	Belongs to the glutathione peroxidase family
C2I25_01085	COG0426	domain, Protein
C2I25_01085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2I25_01100	COG1595	DNA-templated transcription, initiation
C2I25_01105	COG0604	alcohol dehydrogenase
C2I25_01115	COG0346	lactoylglutathione lyase activity
C2I25_01120	COG1082	Xylose isomerase domain protein TIM barrel
C2I25_01140	COG2226	methyltransferase
C2I25_01165	COG3874	Sporulation protein YtfJ
C2I25_01190	COG0456	acetyltransferase
C2I25_01220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I25_01225	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I25_01230	COG1819	glycosyl
C2I25_01250	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2I25_01260	COG2814	Major facilitator Superfamily
C2I25_01265	COG1846	Transcriptional regulator
C2I25_01270	COG0561	phosphatase activity
C2I25_01280	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2I25_01295	COG2211	Major facilitator Superfamily
C2I25_01310	COG1876	peptidase activity
C2I25_01325	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2I25_01345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2I25_01350	COG1114	Component of the transport system for branched-chain amino acids
C2I25_01375	COG1253	flavin adenine dinucleotide binding
C2I25_01380	COG2839	Protein conserved in bacteria
C2I25_01385	COG0702	epimerase
C2I25_01400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2I25_01410	COG1607	acyl-coa hydrolase
C2I25_01415	COG3689	TIGRFAM TIGR03943 family protein
C2I25_01420	COG0701	Predicted permease
C2I25_01430	COG2244	polysaccharide biosynthetic process
C2I25_01435	COG0586	Pfam SNARE associated Golgi protein
C2I25_01440	COG1051	belongs to the nudix hydrolase family
C2I25_01445	COG5337	Spore coat protein CotH
C2I25_01470	COG4166	transmembrane transport
C2I25_01480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2I25_01490	COG0702	epimerase
C2I25_01495	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2I25_01500	COG0456	acetyltransferase
C2I25_01505	COG0523	cobalamin synthesis protein
C2I25_01515	COG4989	oxidoreductase activity
C2I25_01520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I25_01525	COG1231	oxidoreductase activity
C2I25_01535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2I25_01550	COG0783	Belongs to the Dps family
C2I25_01555	COG3949	Membrane
C2I25_01575	COG0840	transmembrane signaling receptor activity
C2I25_01600	COG2814	Major facilitator Superfamily
C2I25_01605	COG0667	Aldo Keto reductase
C2I25_01610	COG0640	Transcriptional regulator
C2I25_01615	COG1404	Belongs to the peptidase S8 family
C2I25_01620	COG2002	toxin-antitoxin pair type II binding
C2I25_01625	COG0577	efflux transmembrane transporter activity
C2I25_01660	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2I25_01670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I25_01675	COG1279	arginine transmembrane transporter activity
C2I25_01680	COG2814	Major facilitator Superfamily
C2I25_01690	COG1082	Xylose isomerase domain protein TIM barrel
C2I25_01705	COG0318	PFAM AMP-dependent synthetase and ligase
C2I25_01710	COG4264	IucA IucC family
C2I25_01720	COG1247	-acetyltransferase
C2I25_01725	COG1285	pathogenesis
C2I25_01735	COG0726	polysaccharide deacetylase
C2I25_01740	COG5002	protein histidine kinase activity
C2I25_01745	COG0745	RESPONSE REGULATOR receiver
C2I25_01755	COG1316	TRANSCRIPTIONal
C2I25_01780	COG0460	homoserine dehydrogenase
C2I25_01800	COG0726	polysaccharide deacetylase
C2I25_01815	COG0300	oxidoreductase activity
C2I25_01825	COG5002	protein histidine kinase activity
C2I25_01830	COG0745	RESPONSE REGULATOR receiver
C2I25_01835	COG1132	(ABC) transporter
C2I25_01845	COG0791	NLP P60 protein
C2I25_01845	COG1388	LysM domain
C2I25_01860	COG1686	Belongs to the peptidase S11 family
C2I25_01895	COG1216	Glycosyl transferase, family 2
C2I25_01905	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2I25_01910	COG4988	ABC transporter
C2I25_01915	COG1294	oxidase, subunit
C2I25_01920	COG1271	oxidase subunit
C2I25_01940	COG1942	4-Oxalocrotonate Tautomerase
C2I25_01950	COG0583	DNA-binding transcription factor activity
C2I25_01970	COG0411	ABC transporter
C2I25_01980	COG0523	cobalamin synthesis protein
C2I25_01990	COG1231	oxidoreductase activity
C2I25_02000	COG0628	permease
C2I25_02015	COG0778	Nitroreductase
C2I25_02020	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C2I25_02025	COG1959	2 iron, 2 sulfur cluster binding
C2I25_02030	COG0583	DNA-binding transcription factor activity
C2I25_02035	COG0697	spore germination
C2I25_02040	COG4549	nuclear export factor GLE1
C2I25_02045	COG2372	response to copper ion
C2I25_02045	COG1276	copper resistance
C2I25_02085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2I25_02095	COG1834	amidinotransferase
C2I25_02115	COG1114	Component of the transport system for branched-chain amino acids
C2I25_02150	COG2132	Multicopper oxidase
C2I25_02160	COG0006	proline dipeptidase activity
C2I25_02175	COG0583	DNA-binding transcription factor activity
C2I25_02195	COG4846	Membrane protein involved in cytochrome C biogenesis
C2I25_02200	COG0295	cytidine deaminase activity
C2I25_02205	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C2I25_02210	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2I25_02220	COG2390	Transcriptional regulator
C2I25_02225	COG1309	transcriptional regulator
C2I25_02230	COG1266	CAAX protease self-immunity
C2I25_02245	COG0456	acetyltransferase
C2I25_02260	COG2309	aminopeptidase activity
C2I25_02290	COG0531	amino acid
C2I25_02295	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2I25_02310	COG1914	H( )-stimulated, divalent metal cation uptake system
C2I25_02330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I25_02335	COG4166	transmembrane transport
C2I25_02355	COG0427	acetyl-CoA hydrolase
C2I25_02360	COG3279	Response regulator of the LytR AlgR family
C2I25_02365	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2I25_02375	COG3384	dioxygenase
C2I25_02380	COG2814	Major facilitator Superfamily
C2I25_02400	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2I25_02420	COG0028	Belongs to the TPP enzyme family
C2I25_02425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2I25_02435	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2I25_02465	COG2323	membrane
C2I25_02470	COG5566	PFAM Mor transcription activator
C2I25_02480	COG0733	neurotransmitter:sodium symporter activity
C2I25_02495	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2I25_02500	COG2223	nitrite transmembrane transporter activity
C2I25_02505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2I25_02515	COG0477	Major facilitator Superfamily
C2I25_02525	COG1695	Transcriptional regulator
C2I25_02595	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2I25_02600	COG0784	Response regulator, receiver
C2I25_02605	COG4191	Histidine kinase
C2I25_02610	COG0281	malic enzyme
C2I25_02615	COG1027	Aspartate ammonia-lyase
C2I25_02625	COG0528	UMP kinase activity
C2I25_02630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2I25_02645	COG1131	(ABC) transporter
C2I25_02685	COG2733	membrane
C2I25_02705	COG0457	Tetratricopeptide repeat
C2I25_02720	COG0785	Cytochrome C biogenesis protein
C2I25_02740	COG3340	Belongs to the peptidase S51 family
C2I25_02745	COG0534	Mate efflux family protein
C2I25_02775	COG0789	Transcriptional regulator
C2I25_02780	COG1757	Na H antiporter
C2I25_02795	COG0701	Predicted permease
C2I25_02805	COG0523	cobalamin synthesis protein
C2I25_02815	COG0697	spore germination
C2I25_02820	COG1802	Transcriptional regulator
C2I25_02850	COG0367	asparagine synthase
C2I25_02880	COG0406	alpha-ribazole phosphatase activity
C2I25_02915	COG1177	transmembrane transport
C2I25_02925	COG3842	ATPase activity
C2I25_02955	COG2329	Antibiotic biosynthesis monooxygenase
C2I25_03000	COG4786	Flagellar basal body rod
C2I25_03005	COG1419	protein localization to endoplasmic reticulum
C2I25_03010	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2I25_03015	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2I25_03025	COG1987	bacterial-type flagellum assembly
C2I25_03030	COG1338	Plays a role in the flagellum-specific transport system
C2I25_03040	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2I25_03040	COG1776	CheC inhibitor of MCP methylation
C2I25_03045	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2I25_03055	COG0741	lytic transglycosylase activity
C2I25_03060	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2I25_03065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2I25_03070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2I25_03075	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2I25_03085	COG0784	Response regulator, receiver
C2I25_03085	COG0835	chemotaxis
C2I25_03120	COG1157	protein secretion by the type III secretion system
C2I25_03130	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2I25_03135	COG1766	The M ring may be actively involved in energy transduction
C2I25_03140	COG1677	Flagellar hook-basal body complex protein FliE
C2I25_03145	COG1558	bacterial-type flagellum-dependent cell motility
C2I25_03150	COG1815	bacterial-type flagellum-dependent cell motility
C2I25_03165	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C2I25_03170	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2I25_03175	COG1256	bacterial-type flagellum assembly
C2I25_03195	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C2I25_03210	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2I25_03210	COG1776	CheC inhibitor of MCP methylation
C2I25_03215	COG2198	Histidine kinase
C2I25_03215	COG0643	Histidine kinase
C2I25_03220	COG2201	protein-glutamate methylesterase activity
C2I25_03225	COG1360	Flagellar Motor Protein
C2I25_03230	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2I25_03240	COG1923	regulation of RNA biosynthetic process
C2I25_03300	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C2I25_03305	COG2323	membrane
C2I25_03315	COG0789	Transcriptional regulator
C2I25_03315	COG4978	Transcriptional regulator
C2I25_03320	COG0475	glutathione-regulated potassium exporter activity
C2I25_03330	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2I25_03335	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2I25_03355	COG1280	lysine exporter protein (LysE YggA)
C2I25_03360	COG3403	YqcI/YcgG family
C2I25_03395	COG0328	RNA-DNA hybrid ribonuclease activity
C2I25_03415	COG0454	-acetyltransferase
C2I25_03430	COG0438	transferase activity, transferring glycosyl groups
C2I25_03435	COG1215	transferase activity, transferring glycosyl groups
C2I25_03450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C2I25_03460	COG3944	biosynthesis protein
C2I25_03475	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2I25_03525	COG0456	acetyltransferase
C2I25_03535	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C2I25_03545	COG2311	Membrane
C2I25_03550	COG2233	PERMEase
C2I25_03560	COG0024	Methionine aminopeptidase
C2I25_03570	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C2I25_03575	COG1199	ATP-dependent helicase activity
C2I25_03585	COG0116	Belongs to the methyltransferase superfamily
C2I25_03645	COG4499	WXG100 protein secretion system (Wss), protein YukC
C2I25_03645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2I25_03655	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2I25_03660	COG3935	DnaD domain protein
C2I25_03680	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2I25_03680	COG1199	ATP-dependent helicase activity
C2I25_03720	COG0438	transferase activity, transferring glycosyl groups
C2I25_03740	COG1694	Mazg nucleotide pyrophosphohydrolase
C2I25_03750	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I25_03760	COG2738	Putative neutral zinc metallopeptidase
C2I25_03775	COG4347	Protein of unknown function (DUF1405)
C2I25_03780	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C2I25_03780	COG2010	Cytochrome c
C2I25_03785	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C2I25_03805	COG0457	Tetratricopeptide repeat
C2I25_03830	COG0142	geranyltranstransferase activity
C2I25_03840	COG0142	geranyltranstransferase activity
C2I25_03855	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C2I25_03925	COG0252	asparaginase activity
C2I25_03930	COG0492	ferredoxin-NADP+ reductase activity
C2I25_03950	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2I25_03965	COG1408	metallophosphoesterase
C2I25_03975	COG1266	CAAX protease self-immunity
C2I25_03980	COG0514	ATP-dependent DNA helicase (RecQ)
C2I25_03990	COG1141	Ferredoxin
C2I25_03995	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C2I25_04010	COG2096	Adenosyltransferase
C2I25_04015	COG5002	protein histidine kinase activity
C2I25_04020	COG0745	RESPONSE REGULATOR receiver
C2I25_04025	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2I25_04030	COG1333	cytochrome c biogenesis protein
C2I25_04040	COG1187	pseudouridine synthase activity
C2I25_04045	COG0700	Nucleoside recognition
C2I25_04050	COG2715	membrane protein required for spore maturation
C2I25_04055	COG1686	Belongs to the peptidase S11 family
C2I25_04060	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2I25_04075	COG0392	lysyltransferase activity
C2I25_04075	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C2I25_04095	COG5002	protein histidine kinase activity
C2I25_04100	COG0582	viral genome integration into host DNA
C2I25_04110	COG1801	Protein of unknown function DUF72
C2I25_04115	COG3852	Histidine kinase
C2I25_04130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2I25_04135	COG1392	Phosphate transport regulator
C2I25_04140	COG0306	phosphate transporter
C2I25_04145	COG0730	response to heat
C2I25_04200	COG1114	Component of the transport system for branched-chain amino acids
C2I25_04210	COG2197	response regulator
C2I25_04215	COG4585	Histidine kinase
C2I25_04220	COG4758	membrane
C2I25_04235	COG1757	Na H antiporter
C2I25_04255	COG0733	neurotransmitter:sodium symporter activity
C2I25_04265	COG1648	precorrin-2 dehydrogenase activity
C2I25_04285	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2I25_04290	COG0529	Catalyzes the synthesis of activated sulfate
C2I25_04310	COG0019	diaminopimelate decarboxylase activity
C2I25_04320	COG1368	sulfuric ester hydrolase activity
C2I25_04325	COG1183	phosphatidylcholine synthase activity
C2I25_04340	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C2I25_04415	COG0440	acetolactate synthase activity
C2I25_04420	COG0028	Belongs to the TPP enzyme family
C2I25_04425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2I25_04455	COG3874	Sporulation protein YtfJ
C2I25_04460	COG4709	membrane
C2I25_04465	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2I25_04470	COG1301	dicarboxylic acid transport
C2I25_04480	COG1846	Transcriptional regulator
C2I25_04525	COG3173	Aminoglycoside phosphotransferase
C2I25_04540	COG0716	FMN binding
C2I25_04565	COG1696	Membrane protein involved in D-alanine export
C2I25_04575	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
C2I25_04580	COG2070	2-Nitropropane dioxygenase
C2I25_04585	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2I25_04595	COG1335	isochorismatase
C2I25_04605	COG1522	sequence-specific DNA binding
C2I25_04615	COG1266	CAAX protease self-immunity
C2I25_04620	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C2I25_04625	COG1131	(ABC) transporter
C2I25_04635	COG1131	(ABC) transporter
C2I25_04640	COG1725	Transcriptional regulator
C2I25_04645	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2I25_04650	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2I25_04655	COG1780	Probably involved in ribonucleotide reductase function
C2I25_04690	COG4873	Protein conserved in bacteria
C2I25_04705	COG0720	synthase
C2I25_04715	COG5002	protein histidine kinase activity
C2I25_04725	COG2318	DinB family
C2I25_04735	COG1846	Transcriptional regulator
C2I25_04740	COG3852	Histidine kinase
C2I25_04750	COG2861	carbohydrate metabolic process
C2I25_04760	COG0235	Class ii aldolase
C2I25_04775	COG1349	DNA-binding transcription factor activity
C2I25_04800	COG3842	ATPase activity
C2I25_04805	COG1840	ABC-type Fe3 transport system, periplasmic component
C2I25_04825	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2I25_04835	COG3243	poly(R)-hydroxyalkanoic acid synthase
C2I25_04840	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_04860	COG2030	dehydratase
C2I25_04870	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2I25_04875	COG0861	Integral membrane protein TerC family
C2I25_04880	COG2116	formate transmembrane transporter activity
C2I25_04890	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C2I25_04910	COG2186	Transcriptional regulator
C2I25_04915	COG5002	protein histidine kinase activity
C2I25_04920	COG0745	RESPONSE REGULATOR receiver
C2I25_04930	COG3835	regulator
C2I25_04935	COG0277	FAD linked oxidase domain protein
C2I25_04940	COG0247	lactate metabolic process
C2I25_04945	COG2340	Cysteine-rich secretory protein family
C2I25_04955	COG0564	pseudouridine synthase activity
C2I25_04965	COG2409	Drug exporters of the RND superfamily
C2I25_04975	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2I25_04980	COG1177	transmembrane transport
C2I25_04985	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2I25_04995	COG1012	belongs to the aldehyde dehydrogenase family
C2I25_05030	COG0681	Belongs to the peptidase S26 family
C2I25_05035	COG1686	Belongs to the peptidase S11 family
C2I25_05065	COG1668	transmembrane transport
C2I25_05070	COG4152	abc transporter atp-binding protein
C2I25_05110	COG1476	TRANSCRIPTIONal
C2I25_05120	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2I25_05180	COG5634	Uncharacterized conserved protein (DUF2278)
C2I25_05185	COG1620	l-lactate permease
C2I25_05220	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2I25_05220	COG0512	Glutamine amidotransferase of anthranilate synthase
C2I25_05235	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2I25_05255	COG2382	esterase
C2I25_05265	COG2153	protein acetylation
C2I25_05310	COG1091	dTDP-4-dehydrorhamnose reductase activity
C2I25_05325	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C2I25_05345	COG0457	Tetratricopeptide repeat
C2I25_05345	COG0463	Glycosyl transferase, family 2
C2I25_05365	COG1216	Glycosyl transferase, family 2
C2I25_05370	COG0772	Belongs to the SEDS family
C2I25_05385	COG0564	pseudouridine synthase activity
C2I25_05395	COG2357	RelA SpoT domain protein
C2I25_05405	COG4116	CYTH
C2I25_05410	COG2346	COG2346, Truncated hemoglobins
C2I25_05425	COG1164	Oligoendopeptidase f
C2I25_05435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2I25_05445	COG0861	Integral membrane protein TerC family
C2I25_05450	COG1393	Belongs to the ArsC family
C2I25_05465	COG4166	transmembrane transport
C2I25_05470	COG0534	Mate efflux family protein
C2I25_05475	COG4608	Belongs to the ABC transporter superfamily
C2I25_05480	COG0444	Belongs to the ABC transporter superfamily
C2I25_05485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2I25_05490	COG0601	transmembrane transport
C2I25_05495	COG4166	transmembrane transport
C2I25_05510	COG0180	Tryptophanyl-tRNA synthetase
C2I25_05520	COG5504	Zn-dependent protease
C2I25_05525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2I25_05530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2I25_05545	COG2267	carboxylic ester hydrolase activity
C2I25_05570	COG0561	phosphatase activity
C2I25_05585	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I25_05600	COG2996	Protein conserved in bacteria
C2I25_05625	COG0004	ammonium transporteR
C2I25_05630	COG0753	catalase activity
C2I25_05640	COG0367	asparagine synthase
C2I25_05665	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2I25_05705	COG0202	RNA polymerase activity
C2I25_05725	COG0398	Pfam SNARE associated Golgi protein
C2I25_05745	COG1278	Cold shock
C2I25_05760	COG2224	Isocitrate lyase
C2I25_05765	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C2I25_05775	COG3693	PFAM glycoside hydrolase, family 10
C2I25_05785	COG0840	transmembrane signaling receptor activity
C2I25_05790	COG0501	Belongs to the peptidase M48B family
C2I25_05810	COG0745	RESPONSE REGULATOR receiver
C2I25_05815	COG2205	protein histidine kinase activity
C2I25_05825	COG2207	Transcriptional regulator
C2I25_05825	COG3708	Transcriptional regulator
C2I25_05830	COG1595	DNA-templated transcription, initiation
C2I25_05840	COG0477	Major facilitator Superfamily
C2I25_05850	COG1078	dGTPase activity
C2I25_05860	COG1408	metallophosphoesterase
C2I25_05930	COG4208	sulfate ABC transporter
C2I25_05940	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C2I25_05950	COG0318	PFAM AMP-dependent synthetase and ligase
C2I25_05960	COG0095	Lipoate-protein ligase
C2I25_05965	COG1234	tRNA 3'-trailer cleavage
C2I25_05975	COG1609	Transcriptional regulator
C2I25_06000	COG1511	domain protein
C2I25_06005	COG1309	transcriptional regulator
C2I25_06055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2I25_06060	COG2329	Antibiotic biosynthesis monooxygenase
C2I25_06065	COG3428	Bacterial PH domain
C2I25_06070	COG3402	PFAM membrane-flanked domain
C2I25_06075	COG0697	spore germination
C2I25_06115	COG3428	Bacterial PH domain
C2I25_06120	COG3402	PFAM membrane-flanked domain
C2I25_06130	COG1309	transcriptional regulator
C2I25_06165	COG4473	ABC transporter
C2I25_06170	COG1131	(ABC) transporter
C2I25_06180	COG0537	adenosine 5'-monophosphoramidase activity
C2I25_06185	COG4980	gas vesicle protein
C2I25_06220	COG3973	AAA domain
C2I25_06260	COG1695	Transcriptional regulator
C2I25_06265	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2I25_06275	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2I25_06280	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
C2I25_06290	COG2140	Oxalate decarboxylase
C2I25_06305	COG2267	carboxylic ester hydrolase activity
C2I25_06315	COG0457	Tetratricopeptide repeat
C2I25_06320	COG0346	lactoylglutathione lyase activity
C2I25_06325	COG0346	lactoylglutathione lyase activity
C2I25_06330	COG1280	lysine exporter protein (LysE YggA)
C2I25_06345	COG4717	serine-type aminopeptidase activity
C2I25_06350	COG0420	3'-5' exonuclease activity
C2I25_06370	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
C2I25_06415	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C2I25_06420	COG2208	phosphoserine phosphatase activity
C2I25_06430	COG1191	sigma factor activity
C2I25_06455	COG3237	CsbD-like
C2I25_06485	COG0596	Alpha beta hydrolase
C2I25_06495	COG2373	Large extracellular alpha-helical protein
C2I25_06535	COG2376	Dihydroxyacetone kinase
C2I25_06550	COG2376	Dihydroxyacetone kinase
C2I25_06565	COG0640	Transcriptional regulator
C2I25_06570	COG2814	Major facilitator Superfamily
C2I25_06585	COG1183	phosphatidylcholine synthase activity
C2I25_06645	COG1073	alpha beta
C2I25_06670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I25_06685	COG0477	Major facilitator Superfamily
C2I25_06720	COG0305	Participates in initiation and elongation during chromosome replication
C2I25_06735	COG0789	Transcriptional regulator
C2I25_06735	COG4978	Transcriptional regulator
C2I25_06770	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
C2I25_06800	COG3181	Tripartite tricarboxylate transporter family receptor
C2I25_06805	COG4565	transcriptional regulatory protein
C2I25_06810	COG3290	protein histidine kinase activity
C2I25_06815	COG0477	Major facilitator Superfamily
C2I25_06840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I25_06850	COG4608	Belongs to the ABC transporter superfamily
C2I25_06855	COG0444	Belongs to the ABC transporter superfamily
C2I25_06860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2I25_06865	COG0601	transmembrane transport
C2I25_06905	COG1363	Peptidase, m42
C2I25_06925	COG1024	Enoyl-CoA hydratase
C2I25_06945	COG2244	polysaccharide biosynthetic process
C2I25_06950	COG0659	secondary active sulfate transmembrane transporter activity
C2I25_06965	COG0318	PFAM AMP-dependent synthetase and ligase
C2I25_06970	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2I25_06975	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2I25_06975	COG3409	Peptidoglycan-binding domain 1 protein
C2I25_06985	COG0561	phosphatase activity
C2I25_07000	COG3527	Alpha-acetolactate decarboxylase
C2I25_07005	COG0028	Belongs to the TPP enzyme family
C2I25_07040	COG0189	ligase activity
C2I25_07055	COG1126	abc transporter atp-binding protein
C2I25_07060	COG0765	amino acid transport
C2I25_07065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2I25_07075	COG1132	(ABC) transporter
C2I25_07080	COG1132	(ABC) transporter
C2I25_07100	COG1012	belongs to the aldehyde dehydrogenase family
C2I25_07115	COG0531	amino acid
C2I25_07125	COG0693	protein deglycase activity
C2I25_07145	COG1733	regulation of RNA biosynthetic process
C2I25_07150	COG2814	Major facilitator Superfamily
C2I25_07155	COG1309	transcriptional regulator
C2I25_07165	COG2076	Multidrug Resistance protein
C2I25_07175	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_07180	COG0165	Argininosuccinate lyase
C2I25_07180	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C2I25_07185	COG1522	sequence-specific DNA binding
C2I25_07205	COG2259	Doxx family
C2I25_07215	COG1263	PTS System
C2I25_07215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I25_07225	COG1737	Transcriptional regulator
C2I25_07235	COG0475	glutathione-regulated potassium exporter activity
C2I25_07240	COG0531	amino acid
C2I25_07275	COG0586	Pfam SNARE associated Golgi protein
C2I25_07310	COG3546	catalase activity
C2I25_07315	COG1114	Component of the transport system for branched-chain amino acids
C2I25_07330	COG5522	Integral membrane protein (intg_mem_TP0381)
C2I25_07340	COG1136	(ABC) transporter
C2I25_07345	COG0577	efflux transmembrane transporter activity
C2I25_07350	COG1388	LysM domain
C2I25_07350	COG3584	3D domain protein
C2I25_07375	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2I25_07380	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2I25_07385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I25_07385	COG3711	transcriptional antiterminator
C2I25_07405	COG1283	sodium-dependent phosphate transmembrane transporter activity
C2I25_07410	COG0604	alcohol dehydrogenase
C2I25_07415	COG1316	TRANSCRIPTIONal
C2I25_07425	COG0730	response to heat
C2I25_07430	COG2210	Belongs to the sulfur carrier protein TusA family
C2I25_07445	COG0425	Belongs to the sulfur carrier protein TusA family
C2I25_07450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I25_07450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2I25_07455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2I25_07455	COG0425	Belongs to the sulfur carrier protein TusA family
C2I25_07460	COG1937	Protein conserved in bacteria
C2I25_07465	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2I25_07485	COG1414	Transcriptional regulator
C2I25_07495	COG2719	SpoVR family
C2I25_07500	COG0778	Nitroreductase
C2I25_07550	COG1609	Transcriptional regulator
C2I25_07555	COG1263	PTS System
C2I25_07555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I25_07560	COG1621	beta-fructofuranosidase activity
C2I25_07565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2I25_07580	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_07585	COG2252	PERMEase
C2I25_07590	COG1879	ABC-type sugar transport system periplasmic component
C2I25_07595	COG1129	ABC transporter
C2I25_07600	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2I25_07615	COG1136	(ABC) transporter
C2I25_07640	COG1846	Transcriptional regulator
C2I25_07645	COG2814	Major facilitator Superfamily
C2I25_07650	COG2205	protein histidine kinase activity
C2I25_07695	COG0351	phosphomethylpyrimidine kinase
C2I25_07700	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2I25_07710	COG2104	thiamine diphosphate biosynthetic process
C2I25_07715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2I25_07720	COG0352	thiamine-phosphate diphosphorylase activity
C2I25_07725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2I25_07730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2I25_07735	COG1116	anion transmembrane transporter activity
C2I25_07740	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C2I25_07765	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C2I25_07890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2I25_07900	COG0581	inorganic phosphate transmembrane transporter activity
C2I25_07905	COG0573	inorganic phosphate transmembrane transporter activity
C2I25_07910	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2I25_07915	COG1918	ferrous iron import across plasma membrane
C2I25_07915	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C2I25_07920	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C2I25_07925	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C2I25_07940	COG0531	amino acid
C2I25_07945	COG0697	spore germination
C2I25_07950	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2I25_07965	COG4990	cell redox homeostasis
C2I25_07970	COG0833	amino acid
C2I25_07980	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2I25_07995	COG0569	domain protein
C2I25_07995	COG0475	glutathione-regulated potassium exporter activity
C2I25_08005	COG2153	protein acetylation
C2I25_08020	COG2252	PERMEase
C2I25_08025	COG1113	amino acid transport
C2I25_08040	COG1114	Component of the transport system for branched-chain amino acids
C2I25_08045	COG3104	oligopeptide transport
C2I25_08065	COG1476	TRANSCRIPTIONal
C2I25_08070	COG1388	LysM domain
C2I25_08070	COG3584	3D domain protein
C2I25_08075	COG0840	transmembrane signaling receptor activity
C2I25_08125	COG1063	alcohol dehydrogenase
C2I25_08150	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2I25_08155	COG1879	ABC-type sugar transport system periplasmic component
C2I25_08160	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2I25_08175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2I25_08180	COG1609	Transcriptional regulator
C2I25_08185	COG0477	Major facilitator Superfamily
C2I25_08190	COG1846	Transcriptional regulator
C2I25_08195	COG2271	Major facilitator Superfamily
C2I25_08205	COG4608	Belongs to the ABC transporter superfamily
C2I25_08210	COG0601	transmembrane transport
C2I25_08235	COG0659	secondary active sulfate transmembrane transporter activity
C2I25_08250	COG5002	protein histidine kinase activity
C2I25_08260	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C2I25_08265	COG2378	regulation of single-species biofilm formation
C2I25_08280	COG0833	amino acid
C2I25_08285	COG0765	amino acid transport
C2I25_08290	COG0765	amino acid transport
C2I25_08295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2I25_08300	COG1126	abc transporter atp-binding protein
C2I25_08305	COG1115	amino acid carrier protein
C2I25_08310	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2I25_08315	COG0697	spore germination
C2I25_08330	COG0366	Alpha amylase catalytic
C2I25_08335	COG1263	PTS System
C2I25_08335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I25_08340	COG2188	Transcriptional regulator
C2I25_08345	COG0531	amino acid
C2I25_08365	COG0714	Associated with various cellular activities
C2I25_08370	COG4548	von Willebrand factor, type A
C2I25_08380	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C2I25_08385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2I25_08390	COG0156	8-amino-7-oxononanoate synthase activity
C2I25_08405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I25_08410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I25_08415	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2I25_08420	COG3104	oligopeptide transport
C2I25_08435	COG1620	l-lactate permease
C2I25_08440	COG1027	Aspartate ammonia-lyase
C2I25_08445	COG1253	flavin adenine dinucleotide binding
C2I25_08450	COG0346	lactoylglutathione lyase activity
C2I25_08455	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2I25_08460	COG1316	TRANSCRIPTIONal
C2I25_08465	COG2720	vancomycin resistance protein
C2I25_08485	COG3227	Zinc metalloprotease (Elastase)
C2I25_08495	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C2I25_08500	COG2217	Heavy metal translocating P-type atpase
C2I25_08505	COG0640	Transcriptional regulator
C2I25_08520	COG0531	amino acid
C2I25_08535	COG2427	Protein of unknown function (DUF1641)
C2I25_08540	COG3383	formate dehydrogenase (NAD+) activity
C2I25_08545	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C2I25_08550	COG0456	acetyltransferase
C2I25_08550	COG0454	-acetyltransferase
C2I25_08565	COG5002	protein histidine kinase activity
C2I25_08575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I25_08580	COG0697	spore germination
C2I25_08590	COG0281	malic enzyme
C2I25_08595	COG3493	citrate carrier protein
C2I25_08600	COG4565	transcriptional regulatory protein
C2I25_08605	COG3290	protein histidine kinase activity
C2I25_08615	COG4990	cell redox homeostasis
C2I25_08625	COG5002	protein histidine kinase activity
C2I25_08630	COG0745	RESPONSE REGULATOR receiver
C2I25_08635	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2I25_08645	COG0395	ABC-type sugar transport system, permease component
C2I25_08650	COG1175	transmembrane transport
C2I25_08655	COG3842	ATPase activity
C2I25_08660	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
C2I25_08685	COG2851	Citrate transporter
C2I25_08690	COG4565	transcriptional regulatory protein
C2I25_08695	COG3290	protein histidine kinase activity
C2I25_08705	COG2268	Band 7 protein
C2I25_08710	COG1585	Membrane protein implicated in regulation of membrane protease activity
C2I25_08720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2I25_08750	COG2766	serine protein kinase
C2I25_08765	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C2I25_08790	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C2I25_08915	COG0735	belongs to the Fur family
C2I25_08920	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2I25_08940	COG4555	ABC transporter
C2I25_08950	COG0067	glutamate synthase
C2I25_08950	COG0069	glutamate synthase activity
C2I25_08950	COG0070	glutamate synthase
C2I25_08955	COG4129	membrane
C2I25_08960	COG1132	(ABC) transporter
C2I25_08985	COG1194	a g-specific adenine glycosylase
C2I25_08990	COG1988	membrane-bound metal-dependent
C2I25_09020	COG1090	epimerase
C2I25_09025	COG1228	amidohydrolase
C2I25_09045	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2I25_09060	COG0463	Glycosyl transferase, family 2
C2I25_09065	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C2I25_09065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2I25_09075	COG1216	Glycosyl transferase, family 2
C2I25_09090	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2I25_09095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I25_09095	COG1263	PTS System
C2I25_09135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2I25_09140	COG0833	amino acid
C2I25_09150	COG3829	transcription factor binding
C2I25_09165	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2I25_09170	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C2I25_09190	COG0535	radical SAM domain protein
C2I25_09200	COG0387	Pfam Sodium calcium exchanger
C2I25_09205	COG3871	stress protein (general stress protein 26)
C2I25_09220	COG0586	Pfam SNARE associated Golgi protein
C2I25_09240	COG0697	spore germination
C2I25_09245	COG2217	Heavy metal translocating P-type atpase
C2I25_09255	COG1295	ribonuclease BN
C2I25_09265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2I25_09280	COG3853	Toxic anion resistance protein (TelA)
C2I25_09290	COG0861	Integral membrane protein TerC family
C2I25_09295	COG2310	stress, protein
C2I25_09300	COG2310	stress, protein
C2I25_09305	COG2310	stress, protein
C2I25_09335	COG2270	Major facilitator Superfamily
C2I25_09385	COG0488	(ABC) transporter
C2I25_09390	COG1116	anion transmembrane transporter activity
C2I25_09400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2I25_09420	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2I25_09450	COG2190	(PTS) system
C2I25_09450	COG1263	PTS System
C2I25_09450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I25_09455	COG0366	Alpha amylase catalytic
C2I25_09460	COG0277	FAD linked oxidase domain protein
C2I25_09470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2I25_09475	COG0549	Belongs to the carbamate kinase family
C2I25_09500	COG0840	transmembrane signaling receptor activity
C2I25_09505	COG1126	abc transporter atp-binding protein
C2I25_09510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2I25_09515	COG0765	amino acid transport
C2I25_09525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2I25_09525	COG0723	plastoquinol--plastocyanin reductase activity
C2I25_09530	COG2814	Major facilitator Superfamily
C2I25_09535	COG3541	Predicted nucleotidyltransferase
C2I25_09555	COG5002	protein histidine kinase activity
C2I25_09580	COG0166	Belongs to the GPI family
C2I25_09605	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2I25_09610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I25_09615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I25_09620	COG0235	Class ii aldolase
C2I25_09630	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
C2I25_09635	COG0450	alkyl hydroperoxide reductase
C2I25_09650	COG1473	amidohydrolase
C2I25_09680	COG4807	Protein conserved in bacteria
C2I25_09695	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2I25_09705	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2I25_09720	COG2309	aminopeptidase activity
C2I25_09730	COG2076	Multidrug Resistance protein
C2I25_09735	COG1012	belongs to the aldehyde dehydrogenase family
C2I25_09745	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2I25_09755	COG1597	lipid kinase activity
C2I25_09775	COG4682	membrane
C2I25_09780	COG1846	Transcriptional regulator
C2I25_09785	COG0003	Pfam Anion-transporting ATPase
C2I25_09800	COG1464	Belongs to the NlpA lipoprotein family
C2I25_09805	COG2011	ABC-type metal ion transport system permease component
C2I25_09820	COG1335	isochorismatase
C2I25_09840	COG4851	CamS sex pheromone cAM373 precursor
C2I25_09850	COG0210	DNA helicase
C2I25_09875	COG0583	DNA-binding transcription factor activity
C2I25_09885	COG0151	Belongs to the GarS family
C2I25_09895	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2I25_09905	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C2I25_09920	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2I25_09930	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2I25_09935	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2I25_09940	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2I25_09965	COG0697	spore germination
C2I25_09985	COG1215	transferase activity, transferring glycosyl groups
C2I25_09995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2I25_10035	COG0506	proline dehydrogenase activity
C2I25_10040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I25_10060	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C2I25_10085	COG5002	protein histidine kinase activity
C2I25_10095	COG2252	PERMEase
C2I25_10115	COG1266	CAAX protease self-immunity
C2I25_10130	COG0488	(ABC) transporter
C2I25_10140	COG0456	acetyltransferase
C2I25_10145	COG1214	PFAM Peptidase M22, glycoprotease
C2I25_10150	COG0802	atpase or kinase
C2I25_10250	COG2183	response to ionizing radiation
C2I25_10255	COG2337	Toxic component of a toxin-antitoxin (TA) module
C2I25_10260	COG0864	Transcriptional regulator
C2I25_10265	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2I25_10270	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C2I25_10280	COG0705	Rhomboid family
C2I25_10285	COG4294	response to UV
C2I25_10295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2I25_10305	COG2814	Major facilitator Superfamily
C2I25_10310	COG0531	amino acid
C2I25_10320	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2I25_10325	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C2I25_10355	COG0561	phosphatase activity
C2I25_10360	COG4608	Belongs to the ABC transporter superfamily
C2I25_10365	COG0444	Belongs to the ABC transporter superfamily
C2I25_10370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2I25_10375	COG0601	transmembrane transport
C2I25_10380	COG0747	negative chemotaxis
C2I25_10395	COG0488	(ABC) transporter
C2I25_10420	COG5298	Protein conserved in bacteria
C2I25_10440	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I25_10450	COG1609	Transcriptional regulator
C2I25_10465	COG0204	Acyl-transferase
C2I25_10480	COG0697	spore germination
C2I25_10500	COG1910	domain protein
C2I25_10505	COG0725	ABC transporter, periplasmic molybdate-binding protein
C2I25_10510	COG4149	molybdate abc transporter
C2I25_10530	COG0656	L-ascorbic acid biosynthetic process
C2I25_10535	COG4166	transmembrane transport
C2I25_10540	COG4166	transmembrane transport
C2I25_10555	COG4166	transmembrane transport
C2I25_10560	COG4608	Belongs to the ABC transporter superfamily
C2I25_10565	COG0444	Belongs to the ABC transporter superfamily
C2I25_10570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2I25_10575	COG0601	transmembrane transport
C2I25_10595	COG2814	Major facilitator Superfamily
C2I25_10605	COG2271	Major facilitator Superfamily
C2I25_10610	COG0277	FAD linked oxidase domain protein
C2I25_10620	COG0604	alcohol dehydrogenase
C2I25_10625	COG1464	Belongs to the NlpA lipoprotein family
C2I25_10630	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2I25_10635	COG2011	ABC-type metal ion transport system permease component
C2I25_10640	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_10680	COG4856	YbbR-like protein
C2I25_10685	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C2I25_10770	COG0726	polysaccharide deacetylase
C2I25_10775	COG2194	sulfuric ester hydrolase activity
C2I25_10785	COG0489	protein tyrosine kinase activity
C2I25_10790	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2I25_10815	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C2I25_10850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2I25_10860	COG0024	Methionine aminopeptidase
C2I25_10870	COG0201	protein transport
C2I25_10895	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C2I25_11005	COG1358	cellular component organization or biogenesis
C2I25_11020	COG2813	Specifically methylates the guanine in position
C2I25_11045	COG0250	Participates in transcription elongation, termination and antitermination
C2I25_11050	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2I25_11055	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C2I25_11065	COG3688	RNA-binding protein containing a PIN domain
C2I25_11070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2I25_11085	COG1045	serine acetyltransferase
C2I25_11105	COG4956	integral membrane protein (PIN domain superfamily)
C2I25_11115	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C2I25_11120	COG0542	response to heat
C2I25_11130	COG3880	PFAM UvrB UvrC protein
C2I25_11220	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2I25_11225	COG1396	sequence-specific DNA binding
C2I25_11230	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C2I25_11235	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2I25_11240	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2I25_11245	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2I25_11250	COG0512	Glutamine amidotransferase of anthranilate synthase
C2I25_11255	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2I25_11260	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2I25_11275	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2I25_11290	COG2208	phosphoserine phosphatase activity
C2I25_11305	COG1098	S1 RNA binding domain
C2I25_11325	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C2I25_11330	COG3956	TIGRFAM MazG family protein
C2I25_11335	COG2244	polysaccharide biosynthetic process
C2I25_11340	COG2002	toxin-antitoxin pair type II binding
C2I25_11345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2I25_11360	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2I25_11375	COG0251	oxidation-reduction process
C2I25_11380	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2I25_11395	COG4466	Protein conserved in bacteria
C2I25_11415	COG0084	hydrolase, TatD family'
C2I25_11425	COG2002	toxin-antitoxin pair type II binding
C2I25_11430	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C2I25_11440	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C2I25_11450	COG1774	PSP1 C-terminal conserved region
C2I25_11455	COG0470	DNA polymerase III
C2I25_11465	COG1982	Orn Lys Arg decarboxylase major
C2I25_11520	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C2I25_11530	COG0590	tRNA wobble adenosine to inosine editing
C2I25_11540	COG1335	isochorismatase
C2I25_11545	COG1428	Deoxynucleoside kinase
C2I25_11550	COG1428	Deoxynucleoside kinase
C2I25_11580	COG1686	Belongs to the peptidase S11 family
C2I25_11585	COG0516	GMP reductase activity
C2I25_11585	COG0517	IMP dehydrogenase activity
C2I25_11620	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C2I25_11625	COG0187	DNA topoisomerase II activity
C2I25_11635	COG2501	S4 domain
C2I25_11640	COG0592	DNA-directed DNA polymerase activity
C2I25_11665	COG1847	R3H domain protein
C2I25_11690	COG1192	Involved in chromosome partitioning
C2I25_11695	COG1475	DNA binding
C2I25_11705	COG0668	transmembrane transport
C2I25_11710	COG4481	Protein conserved in bacteria
C2I25_11715	COG0012	GTP binding
C2I25_11725	COG0629	single-stranded DNA binding
C2I25_11735	COG4241	membrane
C2I25_11740	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
C2I25_11750	COG0305	Participates in initiation and elongation during chromosome replication
C2I25_11780	COG0745	RESPONSE REGULATOR receiver
C2I25_11785	COG5002	protein histidine kinase activity
C2I25_11795	COG4853	Protein conserved in bacteria
C2I25_11800	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C2I25_11805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2I25_11820	COG5002	protein histidine kinase activity
C2I25_11855	COG1272	protein, Hemolysin III
C2I25_11885	COG0515	serine threonine protein kinase
C2I25_11890	COG1132	(ABC) transporter
C2I25_11895	COG1695	Transcriptional regulator
C2I25_11915	COG2801	Transposase and inactivated derivatives
C2I25_11920	COG2801	Transposase and inactivated derivatives
C2I25_11925	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2I25_11955	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
C2I25_11960	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2I25_11965	COG2814	Major facilitator Superfamily
C2I25_11970	COG3275	phosphorelay sensor kinase activity
C2I25_11990	COG0628	permease
C2I25_11995	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2I25_11995	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2I25_12000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2I25_12005	COG1309	transcriptional regulator
C2I25_12010	COG0463	Glycosyl transferase, family 2
C2I25_12025	COG0488	(ABC) transporter
C2I25_12035	COG1216	Glycosyl transferase, family 2
C2I25_12045	COG1607	acyl-coa hydrolase
C2I25_12055	COG0840	transmembrane signaling receptor activity
C2I25_12070	COG0438	transferase activity, transferring glycosyl groups
C2I25_12080	COG0477	Major facilitator Superfamily
C2I25_12085	COG3279	Response regulator of the LytR AlgR family
C2I25_12090	COG1966	Carbon starvation protein
C2I25_12095	COG2879	small protein
C2I25_12100	COG3706	GGDEF domain
C2I25_12105	COG0351	phosphomethylpyrimidine kinase
C2I25_12110	COG4585	Histidine kinase
C2I25_12110	COG2203	Gaf domain
C2I25_12115	COG2197	response regulator
C2I25_12125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2I25_12130	COG1011	Hydrolase
C2I25_12150	COG0460	homoserine dehydrogenase
C2I25_12160	COG1609	Transcriptional regulator
C2I25_12165	COG2755	lipolytic protein G-D-S-L family
C2I25_12170	COG1131	(ABC) transporter
C2I25_12175	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C2I25_12185	COG2814	Major facilitator Superfamily
C2I25_12190	COG0561	phosphatase activity
C2I25_12195	COG2233	PERMEase
C2I25_12200	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2I25_12210	COG2363	Small membrane protein
C2I25_12220	COG3773	Cell wall hydrolase
C2I25_12235	COG0280	phosphate acetyltransferase
C2I25_12255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I25_12260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I25_12265	COG1120	ATPase activity
C2I25_12270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2I25_12275	COG1078	dGTPase activity
C2I25_12285	COG1994	Peptidase M50
C2I25_12295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2I25_12300	COG0584	glycerophosphoryl diester phosphodiesterase
C2I25_12305	COG0789	Transcriptional regulator
C2I25_12310	COG2814	Major facilitator Superfamily
C2I25_12315	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C2I25_12340	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2I25_12345	COG4506	Protein conserved in bacteria
C2I25_12355	COG1595	DNA-templated transcription, initiation
C2I25_12375	COG2234	aminopeptidase activity
C2I25_12385	COG0024	Methionine aminopeptidase
C2I25_12390	COG1131	(ABC) transporter
C2I25_12395	COG0842	Transport permease protein
C2I25_12400	COG4585	Histidine kinase
C2I25_12405	COG2197	response regulator
C2I25_12410	COG3227	Zinc metalloprotease (Elastase)
C2I25_12425	COG5001	Diguanylate cyclase
C2I25_12425	COG3300	MHYT domain
C2I25_12435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2I25_12440	COG0247	lactate metabolic process
C2I25_12440	COG2181	nitrate reductase activity
C2I25_12445	COG0183	Belongs to the thiolase family
C2I25_12450	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2I25_12455	COG1960	acyl-CoA dehydrogenase activity
C2I25_12460	COG1960	acyl-CoA dehydrogenase activity
C2I25_12480	COG4821	SIS domain
C2I25_12500	COG1494	fructose-1,6-bisphosphatase
C2I25_12505	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C2I25_12525	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C2I25_12545	COG0009	L-threonylcarbamoyladenylate synthase
C2I25_12560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2I25_12565	COG2259	Doxx family
C2I25_12570	COG2190	(PTS) system
C2I25_12585	COG0698	ribose 5-phosphate isomerase
C2I25_12625	COG0356	it plays a direct role in the translocation of protons across the membrane
C2I25_12675	COG3300	MHYT domain
C2I25_12675	COG5001	Diguanylate cyclase
C2I25_12690	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2I25_12710	COG0839	Belongs to the complex I subunit 6 family
C2I25_12720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2I25_12725	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C2I25_12730	COG1007	ATP synthesis coupled electron transport
C2I25_12735	COG4836	Membrane
C2I25_12745	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2I25_12750	COG2385	sporulation resulting in formation of a cellular spore
C2I25_12755	COG3279	Response regulator of the LytR AlgR family
C2I25_12770	COG0739	heme binding
C2I25_12780	COG1609	Transcriptional regulator
C2I25_12795	COG0489	protein tyrosine kinase activity
C2I25_12800	COG3944	biosynthesis protein
C2I25_12805	COG0489	protein tyrosine kinase activity
C2I25_12810	COG4464	protein tyrosine phosphatase activity
C2I25_12815	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2I25_12820	COG1086	Polysaccharide biosynthesis protein
C2I25_12830	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2I25_12840	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C2I25_12845	COG0438	transferase activity, transferring glycosyl groups
C2I25_12855	COG1216	Glycosyl transferase, family 2
C2I25_12875	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2I25_12880	COG0745	RESPONSE REGULATOR receiver
C2I25_12885	COG5002	protein histidine kinase activity
C2I25_12920	COG1136	(ABC) transporter
C2I25_12925	COG0577	efflux transmembrane transporter activity
C2I25_12935	COG1191	sigma factor activity
C2I25_12965	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2I25_12970	COG4715	Zinc finger, swim domain protein
C2I25_12995	COG1388	LysM domain
C2I25_12995	COG3584	3D domain protein
C2I25_13005	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2I25_13015	COG1215	transferase activity, transferring glycosyl groups
C2I25_13025	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2I25_13030	COG0791	NLP P60 protein
C2I25_13030	COG1388	LysM domain
C2I25_13050	COG1368	sulfuric ester hydrolase activity
C2I25_13065	COG2389	metal-binding protein
C2I25_13075	COG1620	l-lactate permease
C2I25_13110	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2I25_13115	COG1294	oxidase, subunit
C2I25_13120	COG1271	oxidase subunit
C2I25_13125	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C2I25_13130	COG0583	DNA-binding transcription factor activity
C2I25_13135	COG1511	domain protein
C2I25_13150	COG1301	dicarboxylic acid transport
C2I25_13155	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2I25_13165	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2I25_13185	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2I25_13190	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2I25_13195	COG1486	melibiose metabolic process
C2I25_13215	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2I25_13215	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C2I25_13225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2I25_13230	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C2I25_13235	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C2I25_13240	COG1316	TRANSCRIPTIONal
C2I25_13245	COG1739	Uncharacterized protein family UPF0029
C2I25_13250	COG1307	EDD domain protein, DegV family
C2I25_13260	COG1733	regulation of RNA biosynthetic process
C2I25_13265	COG0791	NLP P60 protein
C2I25_13265	COG1388	LysM domain
C2I25_13270	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C2I25_13275	COG1040	competence protein
C2I25_13280	COG1278	Cold shock
C2I25_13285	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2I25_13310	COG2884	Cell division ATP-binding protein ftsE
C2I25_13315	COG2177	Part of the ABC transporter FtsEX involved in
C2I25_13320	COG0793	Belongs to the peptidase S41A family
C2I25_13320	COG3409	Peptidoglycan-binding domain 1 protein
C2I25_13325	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2I25_13330	COG1132	(ABC) transporter
C2I25_13340	COG0488	(ABC) transporter
C2I25_13345	COG0655	NAD(P)H dehydrogenase (quinone) activity
C2I25_13355	COG0583	DNA-binding transcription factor activity
C2I25_13375	COG0789	Transcriptional regulator
C2I25_13395	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C2I25_13405	COG1950	PFAM Membrane protein of
C2I25_13425	COG0110	maltose O-acetyltransferase activity
C2I25_13430	COG0457	Tetratricopeptide repeat
C2I25_13435	COG0492	ferredoxin-NADP+ reductase activity
C2I25_13445	COG1051	belongs to the nudix hydrolase family
C2I25_13455	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C2I25_13465	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I25_13475	COG2323	membrane
C2I25_13490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2I25_13515	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2I25_13530	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2I25_13565	COG1346	cytolysis
C2I25_13570	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2I25_13575	COG1647	Serine aminopeptidase, S33
C2I25_13580	COG0557	exoribonuclease II activity
C2I25_13660	COG1335	isochorismatase
C2I25_13670	COG3223	Belongs to the PsiE family
C2I25_13675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I25_13725	COG1252	NADH dehydrogenase
C2I25_13735	COG1733	regulation of RNA biosynthetic process
C2I25_13740	COG2814	Major facilitator Superfamily
C2I25_13745	COG0656	L-ascorbic acid biosynthetic process
C2I25_13765	COG2910	NAD(P)H-binding
C2I25_13770	COG1115	amino acid carrier protein
C2I25_13775	COG1115	amino acid carrier protein
C2I25_13780	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2I25_13785	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2I25_13790	COG2311	Membrane
C2I25_13795	COG1528	Iron-storage protein
C2I25_13805	COG1611	Belongs to the LOG family
C2I25_13810	COG2318	DinB family
C2I25_13820	COG0783	Belongs to the Dps family
C2I25_13825	COG1115	amino acid carrier protein
C2I25_13835	COG0490	domain, Protein
C2I25_13840	COG0475	glutathione-regulated potassium exporter activity
C2I25_13845	COG0586	Pfam SNARE associated Golgi protein
C2I25_13865	COG3227	Zinc metalloprotease (Elastase)
C2I25_13870	COG2151	metal-sulfur cluster biosynthetic enzyme
C2I25_13875	COG0840	transmembrane signaling receptor activity
C2I25_13905	COG5002	protein histidine kinase activity
C2I25_13910	COG0745	RESPONSE REGULATOR receiver
C2I25_13915	COG1376	ErfK ybiS ycfS ynhG family protein
C2I25_13925	COG0586	Pfam SNARE associated Golgi protein
C2I25_13970	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I25_13995	COG0531	amino acid
C2I25_14000	COG2814	Major facilitator Superfamily
C2I25_14015	COG0840	transmembrane signaling receptor activity
C2I25_14020	COG0011	TIGRFAM Protein of
C2I25_14035	COG1686	Belongs to the peptidase S11 family
C2I25_14045	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2I25_14045	COG1024	Enoyl-CoA hydratase
C2I25_14050	COG0183	Belongs to the thiolase family
C2I25_14060	COG1960	acyl-CoA dehydrogenase activity
C2I25_14065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I25_14070	COG1309	transcriptional regulator
C2I25_14090	COG0039	L-malate dehydrogenase activity
C2I25_14135	COG1393	Belongs to the ArsC family
C2I25_14150	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C2I25_14155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2I25_14170	COG2011	ABC-type metal ion transport system permease component
C2I25_14175	COG1464	Belongs to the NlpA lipoprotein family
C2I25_14180	COG1464	Belongs to the NlpA lipoprotein family
C2I25_14185	COG0396	ATPase activity
C2I25_14190	COG0719	Fe-S assembly protein
C2I25_14195	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2I25_14200	COG0822	iron-sulfur transferase activity
C2I25_14205	COG0719	Fe-S assembly protein
C2I25_14215	COG0737	Belongs to the 5'-nucleotidase family
C2I25_14220	COG3377	Domain of unknown function (DUF1805)
C2I25_14230	COG0739	heme binding
C2I25_14255	COG4377	Putative membrane peptidase family (DUF2324)
C2I25_14260	COG0789	Transcriptional regulator
C2I25_14270	COG4470	Protein conserved in bacteria
C2I25_14290	COG1494	fructose-1,6-bisphosphatase
C2I25_14295	COG2445	Protein of unknown function DUF86
C2I25_14305	COG0647	UMP catabolic process
C2I25_14310	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2I25_14320	COG1358	cellular component organization or biogenesis
C2I25_14340	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2I25_14345	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2I25_14355	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C2I25_14360	COG4837	Protein of unknown function (DUF1462)
C2I25_14410	COG2824	Alkylphosphonate utilization operon protein PhnA
C2I25_14420	COG0390	transport system, permease component
C2I25_14425	COG2274	protein secretion by the type I secretion system
C2I25_14435	COG1252	NADH dehydrogenase
C2I25_14450	COG0316	Belongs to the HesB IscA family
C2I25_14485	COG1683	Conserved Protein
C2I25_14500	COG3708	Transcriptional regulator
C2I25_14515	COG1252	NADH dehydrogenase
C2I25_14530	COG3584	3D domain protein
C2I25_14545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2I25_14550	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2I25_14555	COG1268	BioY protein
C2I25_14565	COG2050	protein possibly involved in aromatic compounds catabolism
C2I25_14570	COG0423	glycine-tRNA ligase activity
C2I25_14590	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2I25_14595	COG5018	Exonuclease
C2I25_14610	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C2I25_14620	COG2267	carboxylic ester hydrolase activity
C2I25_14625	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2I25_14630	COG1522	sequence-specific DNA binding
C2I25_14635	COG0436	Aminotransferase
C2I25_14640	COG1098	S1 RNA binding domain
C2I25_14645	COG2155	Conserved Protein
C2I25_14665	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2I25_14670	COG1285	pathogenesis
C2I25_14815	COG1404	Belongs to the peptidase S8 family
C2I25_14835	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2I25_14845	COG0058	SHG alpha-glucan phosphorylase activity
C2I25_14875	COG1278	Cold shock
C2I25_14880	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2I25_14885	COG1575	Belongs to the MenA family. Type 1 subfamily
C2I25_14890	COG1169	isochorismate synthase
C2I25_14900	COG0596	Alpha beta hydrolase
C2I25_14905	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C2I25_14915	COG4948	Mandelate Racemase Muconate Lactonizing
C2I25_14935	COG3964	amidohydrolase
C2I25_14980	COG0577	efflux transmembrane transporter activity
C2I25_14985	COG1136	(ABC) transporter
C2I25_14990	COG0577	efflux transmembrane transporter activity
C2I25_14995	COG0577	efflux transmembrane transporter activity
C2I25_15000	COG2205	protein histidine kinase activity
C2I25_15005	COG0745	RESPONSE REGULATOR receiver
C2I25_15010	COG1595	DNA-templated transcription, initiation
C2I25_15025	COG0640	Transcriptional regulator
C2I25_15030	COG5658	integral membrane protein
C2I25_15040	COG2207	Transcriptional regulator
C2I25_15040	COG3708	Transcriptional regulator
C2I25_15045	COG1136	(ABC) transporter
C2I25_15050	COG0577	efflux transmembrane transporter activity
C2I25_15060	COG0586	Pfam SNARE associated Golgi protein
C2I25_15100	COG1597	lipid kinase activity
C2I25_15130	COG0745	RESPONSE REGULATOR receiver
C2I25_15135	COG5002	protein histidine kinase activity
C2I25_15140	COG3859	Proton-coupled thiamine transporter YuaJ
C2I25_15165	COG1842	Phage shock protein A
C2I25_15190	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I25_15205	COG1294	oxidase, subunit
C2I25_15210	COG1271	oxidase subunit
C2I25_15215	COG0288	reversible hydration of carbon dioxide
C2I25_15230	COG0789	Transcriptional regulator
C2I25_15235	COG2076	Multidrug Resistance protein
C2I25_15240	COG2076	Multidrug Resistance protein
C2I25_15275	COG0494	nUDIX hydrolase
C2I25_15300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2I25_15305	COG1116	anion transmembrane transporter activity
C2I25_15310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2I25_15325	COG1368	sulfuric ester hydrolase activity
C2I25_15330	COG2267	carboxylic ester hydrolase activity
C2I25_15340	COG3852	Histidine kinase
C2I25_15345	COG5002	protein histidine kinase activity
C2I25_15440	COG0438	transferase activity, transferring glycosyl groups
C2I25_15445	COG0671	phosphoesterase, PA-phosphatase related
C2I25_15450	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2I25_15455	COG2267	carboxylic ester hydrolase activity
C2I25_15480	COG1794	racemase activity, acting on amino acids and derivatives
C2I25_15500	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C2I25_15505	COG1242	4 iron, 4 sulfur cluster binding
C2I25_15525	COG1136	(ABC) transporter
C2I25_15535	COG0582	viral genome integration into host DNA
C2I25_15540	COG0490	domain, Protein
C2I25_15545	COG0475	glutathione-regulated potassium exporter activity
C2I25_15550	COG2814	Major facilitator Superfamily
C2I25_15590	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2I25_15600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2I25_15625	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2I25_15630	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2I25_15640	COG0303	'Molybdopterin
C2I25_15645	COG1763	Mo-molybdopterin cofactor biosynthetic process
C2I25_15650	COG0314	molybdopterin synthase activity
C2I25_15675	COG1329	Transcriptional regulator
C2I25_15700	COG3832	glyoxalase III activity
C2I25_15710	COG2814	Major facilitator Superfamily
C2I25_15715	COG2081	HI0933 family
C2I25_15720	COG2244	polysaccharide biosynthetic process
C2I25_15725	COG1187	pseudouridine synthase activity
C2I25_15730	COG1349	DNA-binding transcription factor activity
C2I25_15735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2I25_15745	COG1523	belongs to the glycosyl hydrolase 13 family
C2I25_15750	COG0510	thiamine kinase activity
C2I25_15765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I25_15775	COG1363	Peptidase, m42
C2I25_15780	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
C2I25_15785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2I25_15795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2I25_15805	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2I25_15810	COG1674	ftsk spoiiie
C2I25_15830	COG1695	Transcriptional regulator
C2I25_15835	COG0789	Transcriptional regulator
C2I25_15840	COG0697	spore germination
C2I25_15845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I25_15855	COG2309	aminopeptidase activity
C2I25_15865	COG3118	belongs to the thioredoxin family
C2I25_15870	COG4851	CamS sex pheromone cAM373 precursor
C2I25_15875	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C2I25_15875	COG1605	Chorismate mutase
C2I25_15885	COG1605	Chorismate mutase
C2I25_15885	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C2I25_15895	COG1609	Transcriptional regulator
C2I25_15925	COG0666	response to abiotic stimulus
C2I25_15930	COG5002	protein histidine kinase activity
C2I25_15935	COG0745	RESPONSE REGULATOR receiver
C2I25_15950	COG0123	including yeast histone deacetylase and acetoin utilization protein
C2I25_15955	COG0517	IMP dehydrogenase activity
C2I25_15960	COG0454	-acetyltransferase
C2I25_15965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2I25_15980	COG1595	DNA-templated transcription, initiation
C2I25_16020	COG0626	cystathionine gamma-synthase activity
C2I25_16025	COG1956	GAF domain-containing protein
C2I25_16030	COG1309	transcriptional regulator
C2I25_16035	COG0697	spore germination
C2I25_16040	COG0583	DNA-binding transcription factor activity
C2I25_16050	COG1104	cysteine desulfurase activity
C2I25_16065	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2I25_16075	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C2I25_16095	COG3874	Sporulation protein YtfJ
C2I25_16100	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C2I25_16105	COG0827	DNA restriction-modification system
C2I25_16130	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I25_16170	COG0589	response to stress
C2I25_16175	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_16190	COG0662	Cupin 2, conserved barrel domain protein
C2I25_16195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I25_16230	COG0006	proline dipeptidase activity
C2I25_16245	COG4109	DRTGG domain
C2I25_16260	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C2I25_16275	COG0587	DNA-directed DNA polymerase activity
C2I25_16280	COG0281	malic enzyme
C2I25_16285	COG1725	Transcriptional regulator
C2I25_16310	COG3030	protein affecting phage T7 exclusion by the F plasmid
C2I25_16315	COG0628	permease
C2I25_16330	COG0372	Belongs to the citrate synthase family
C2I25_16335	COG0538	isocitrate dehydrogenase activity
C2I25_16360	COG0745	RESPONSE REGULATOR receiver
C2I25_16365	COG5002	protein histidine kinase activity
C2I25_16370	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2I25_16370	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2I25_16380	COG1971	Probably functions as a manganese efflux pump
C2I25_16385	COG0237	dephospho-CoA kinase activity
C2I25_16390	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2I25_16400	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C2I25_16410	COG3611	Membrane attachment protein
C2I25_16415	COG1484	DNA-dependent DNA replication
C2I25_16430	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2I25_16455	COG1363	Peptidase, m42
C2I25_16460	COG1309	transcriptional regulator
C2I25_16465	COG1566	PFAM secretion protein HlyD family protein
C2I25_16470	COG2814	Major facilitator Superfamily
C2I25_16490	COG1418	mRNA catabolic process
C2I25_16500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2I25_16515	COG0017	Asparaginyl-tRNA synthetase
C2I25_16545	COG1286	toxin biosynthetic process
C2I25_16550	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C2I25_16550	COG1796	DNA polymerase
C2I25_16565	COG1187	pseudouridine synthase activity
C2I25_16570	COG1114	Component of the transport system for branched-chain amino acids
C2I25_16575	COG5386	Cell surface protein
C2I25_16585	COG5386	Cell surface protein
C2I25_16600	COG1120	ATPase activity
C2I25_16605	COG4509	Sortase family
C2I25_16615	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C2I25_16620	COG4895	conserved protein (DUF2196)
C2I25_16630	COG0745	RESPONSE REGULATOR receiver
C2I25_16635	COG2205	protein histidine kinase activity
C2I25_16640	COG1131	(ABC) transporter
C2I25_16670	COG2318	DinB family
C2I25_16695	COG0318	PFAM AMP-dependent synthetase and ligase
C2I25_16700	COG1309	transcriptional regulator
C2I25_16705	COG1024	Enoyl-CoA hydratase
C2I25_16710	COG2086	electron transfer activity
C2I25_16715	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C2I25_16720	COG3118	belongs to the thioredoxin family
C2I25_16730	COG1719	4-vinyl reductase, 4VR
C2I25_16735	COG2009	succinate dehydrogenase
C2I25_16740	COG1053	succinate dehydrogenase
C2I25_16745	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2I25_16750	COG0824	Thioesterase
C2I25_16755	COG1876	peptidase activity
C2I25_16765	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2I25_16770	COG1360	Flagellar Motor Protein
C2I25_16775	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
C2I25_16780	COG4152	abc transporter atp-binding protein
C2I25_16785	COG1668	transmembrane transport
C2I25_16790	COG1959	2 iron, 2 sulfur cluster binding
C2I25_16800	COG0697	spore germination
C2I25_16805	COG1396	sequence-specific DNA binding
C2I25_16810	COG1983	PspC domain protein
C2I25_16815	COG0402	S-adenosylhomocysteine deaminase activity
C2I25_16820	COG2233	PERMEase
C2I25_16825	COG2197	response regulator
C2I25_16835	COG1309	transcriptional regulator
C2I25_16855	COG5401	PFAM Sporulation and spore germination
C2I25_16870	COG0622	Phosphoesterase
C2I25_16925	COG1067	ATP-dependent peptidase activity
C2I25_16925	COG0470	DNA polymerase III
C2I25_16940	COG1764	response to oxidative stress
C2I25_16945	COG1846	Transcriptional regulator
C2I25_16955	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2I25_16965	COG1587	Uroporphyrinogen-III synthase
C2I25_16970	COG0113	porphobilinogen synthase activity
C2I25_16980	COG1388	LysM domain
C2I25_16995	COG0285	dihydrofolate synthase activity
C2I25_17015	COG1077	Cell shape determining protein MreB Mrl
C2I25_17020	COG1792	Involved in formation and maintenance of cell shape
C2I25_17035	COG2894	cell division
C2I25_17040	COG0739	heme binding
C2I25_17045	COG1994	Peptidase M50
C2I25_17050	COG1530	ribonuclease E activity
C2I25_17060	COG2868	ribosomal protein
C2I25_17070	COG3290	protein histidine kinase activity
C2I25_17080	COG0745	RESPONSE REGULATOR receiver
C2I25_17085	COG5002	protein histidine kinase activity
C2I25_17090	COG1136	(ABC) transporter
C2I25_17095	COG0577	efflux transmembrane transporter activity
C2I25_17100	COG0577	efflux transmembrane transporter activity
C2I25_17105	COG0077	Prephenate dehydratase
C2I25_17110	COG2258	MOSC domain
C2I25_17115	COG1827	regulation of RNA biosynthetic process
C2I25_17120	COG1104	cysteine desulfurase activity
C2I25_17125	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2I25_17130	COG0157	Belongs to the NadC ModD family
C2I25_17160	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C2I25_17190	COG1862	Preprotein translocase
C2I25_17200	COG2323	membrane
C2I25_17205	COG2244	polysaccharide biosynthetic process
C2I25_17215	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2I25_17215	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2I25_17220	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C2I25_17225	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2I25_17225	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C2I25_17235	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2I25_17260	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2I25_17280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2I25_17285	COG1959	2 iron, 2 sulfur cluster binding
C2I25_17290	COG1104	cysteine desulfurase activity
C2I25_17305	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2I25_17325	COG0628	permease
C2I25_17355	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2I25_17385	COG0768	penicillin binding
C2I25_17410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2I25_17415	COG0626	cystathionine gamma-synthase activity
C2I25_17420	COG1012	belongs to the aldehyde dehydrogenase family
C2I25_17420	COG1454	alcohol dehydrogenase
C2I25_17435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2I25_17480	COG2259	Doxx family
C2I25_17485	COG2514	catechol 2,3-dioxygenase activity
C2I25_17495	COG3186	Phenylalanine-4-hydroxylase
C2I25_17500	COG1404	Belongs to the peptidase S8 family
C2I25_17535	COG2267	carboxylic ester hydrolase activity
C2I25_17545	COG1785	Belongs to the alkaline phosphatase family
C2I25_17555	COG2357	RelA SpoT domain protein
C2I25_17560	COG0778	Nitroreductase
C2I25_17570	COG1595	DNA-templated transcription, initiation
C2I25_17580	COG1191	sigma factor activity
C2I25_17595	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
C2I25_17600	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C2I25_17610	COG1534	Rna-binding protein
C2I25_17620	COG1713	HD superfamily hydrolase involved in NAD metabolism
C2I25_17625	COG0799	negative regulation of ribosome biogenesis
C2I25_17630	COG2226	methyltransferase
C2I25_17635	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2I25_17640	COG1555	photosystem II stabilization
C2I25_17640	COG1596	polysaccharide export
C2I25_17645	COG2131	deaminase
C2I25_17650	COG0658	competence protein
C2I25_17650	COG2333	competence protein COMEC
C2I25_17660	COG1466	dna polymerase III delta subunit
C2I25_17685	COG1733	regulation of RNA biosynthetic process
C2I25_17690	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2I25_17720	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2I25_17725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2I25_17740	COG1610	YqeY-like protein
C2I25_17760	COG1702	phosphate starvation-inducible protein PhoH
C2I25_17765	COG1480	7TM receptor with intracellular HD hydrolase
C2I25_17775	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2I25_17780	COG0295	cytidine deaminase activity
C2I25_17785	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C2I25_17800	COG0517	IMP dehydrogenase activity
C2I25_17820	COG0358	DNA primase activity
C2I25_17825	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2I25_17835	COG2384	SAM-dependent methyltransferase
C2I25_17840	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2I25_17870	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I25_17875	COG1121	(ABC) transporter
C2I25_17880	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2I25_17885	COG0735	belongs to the Fur family
C2I25_17900	COG5521	maltodextrose utilization protein MalA
C2I25_17910	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2I25_17915	COG0477	Major facilitator Superfamily
C2I25_17925	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2I25_17930	COG0573	inorganic phosphate transmembrane transporter activity
C2I25_17935	COG0573	inorganic phosphate transmembrane transporter activity
C2I25_17950	COG0704	Plays a role in the regulation of phosphate uptake
C2I25_17955	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C2I25_17965	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2I25_17970	COG4483	Protein conserved in bacteria
C2I25_17975	COG1940	carbohydrate kinase activity
C2I25_17985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I25_18005	COG0626	cystathionine gamma-synthase activity
C2I25_18010	COG0626	cystathionine gamma-synthase activity
C2I25_18015	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C2I25_18015	COG0646	methionine synthase
C2I25_18020	COG0646	methionine synthase
C2I25_18020	COG1410	methionine synthase
C2I25_18090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2I25_18095	COG1459	type II secretion system
C2I25_18165	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2I25_18200	COG1725	Transcriptional regulator
C2I25_18240	COG2076	Multidrug Resistance protein
C2I25_18245	COG2076	Multidrug Resistance protein
C2I25_18255	COG1609	Transcriptional regulator
C2I25_18265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2I25_18300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2I25_18310	COG3872	metal-dependent enzyme
C2I25_18325	COG0006	proline dipeptidase activity
C2I25_18350	COG3854	ATPases associated with a variety of cellular activities
C2I25_18395	COG0511	ligase activity, forming carbon-carbon bonds
C2I25_18400	COG0439	Biotin carboxylase
C2I25_18405	COG1302	Protein conserved in bacteria
C2I25_18430	COG0142	geranyltranstransferase activity
C2I25_18440	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C2I25_18450	COG0497	DNA recombination
C2I25_18455	COG0750	zinc metalloprotease
C2I25_18555	COG3093	addiction module antidote protein HigA
C2I25_18560	COG0584	glycerophosphoryl diester phosphodiesterase
C2I25_18570	COG3290	protein histidine kinase activity
C2I25_18570	COG3829	transcription factor binding
C2I25_18580	COG0280	phosphate acetyltransferase
C2I25_18585	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2I25_18595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2I25_18600	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2I25_18605	COG0022	dehydrogenase e1 component
C2I25_18610	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2I25_18620	COG0772	Belongs to the SEDS family
C2I25_18625	COG2323	membrane
C2I25_18645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2I25_18650	COG0765	amino acid transport
C2I25_18655	COG1126	abc transporter atp-binding protein
C2I25_18660	COG4129	membrane
C2I25_18665	COG1376	ErfK ybiS ycfS ynhG family protein
C2I25_18680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I25_18685	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2I25_18700	COG1285	pathogenesis
C2I25_18730	COG1760	l-serine dehydratase
C2I25_18735	COG1760	l-serine dehydratase
C2I25_18740	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2I25_18745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I25_18750	COG0300	oxidoreductase activity
C2I25_18785	COG5444	nuclease activity
C2I25_18820	COG1522	sequence-specific DNA binding
C2I25_18830	COG0737	Belongs to the 5'-nucleotidase family
C2I25_18850	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2I25_18865	COG2226	methyltransferase
C2I25_18865	COG1073	alpha beta
C2I25_18895	COG0307	riboflavin synthase, alpha
C2I25_18900	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2I25_18900	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2I25_18920	COG1073	alpha beta
C2I25_18925	COG0456	acetyltransferase
C2I25_18930	COG1609	Transcriptional regulator
C2I25_18935	COG2056	Na+-H+ antiporter family
C2I25_18940	COG0596	Alpha beta hydrolase
C2I25_18950	COG1525	nuclease
C2I25_18950	COG0737	Belongs to the 5'-nucleotidase family
C2I25_18950	COG4085	toxin activity
C2I25_18960	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C2I25_18960	COG0456	acetyltransferase
C2I25_18965	COG0656	L-ascorbic acid biosynthetic process
C2I25_18970	COG0667	Aldo Keto reductase
C2I25_18990	COG1300	Membrane
C2I25_18995	COG0735	belongs to the Fur family
C2I25_19005	COG4974	Belongs to the 'phage' integrase family
C2I25_19030	COG0598	Magnesium transport protein CorA
C2I25_19045	COG1846	Transcriptional regulator
C2I25_19065	COG1131	(ABC) transporter
C2I25_19070	COG1725	Transcriptional regulator
C2I25_19080	COG1686	Belongs to the peptidase S11 family
C2I25_19100	COG0733	neurotransmitter:sodium symporter activity
C2I25_19125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2I25_19140	COG0697	spore germination
C2I25_19145	COG0561	phosphatase activity
C2I25_19150	COG4086	secreted protein
C2I25_19155	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2I25_19160	COG0456	acetyltransferase
C2I25_19165	COG1547	Domain of unknown function (DUF309)
C2I25_19195	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2I25_19215	COG3711	transcriptional antiterminator
C2I25_19220	COG2190	(PTS) system
C2I25_19220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I25_19220	COG1263	PTS System
C2I25_19245	COG0778	Nitroreductase
C2I25_19250	COG2199	diguanylate cyclase activity
C2I25_19250	COG2203	Gaf domain
C2I25_19260	COG2084	Dehydrogenase
C2I25_19295	COG0436	Aminotransferase
C2I25_19300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2I25_19320	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_19325	COG1695	Transcriptional regulator
C2I25_19360	COG0183	Belongs to the thiolase family
C2I25_19400	COG3842	ATPase activity
C2I25_19405	COG0366	Alpha amylase catalytic
C2I25_19415	COG2182	Extracellular solute-binding protein
C2I25_19420	COG1175	transmembrane transport
C2I25_19425	COG3833	ABC-type maltose transport systems, permease component
C2I25_19430	COG1609	Transcriptional regulator
C2I25_19435	COG0436	Aminotransferase
C2I25_19445	COG2205	protein histidine kinase activity
C2I25_19460	COG3209	COG3209 Rhs family protein
C2I25_19480	COG2814	Major facilitator Superfamily
C2I25_19525	COG1408	metallophosphoesterase
C2I25_19530	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_19535	COG2200	EAL domain
C2I25_19550	COG4703	Protein of unknown function (DUF1797)
C2I25_19560	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
C2I25_19570	COG0517	IMP dehydrogenase activity
C2I25_19575	COG0583	DNA-binding transcription factor activity
C2I25_19595	COG0569	domain protein
C2I25_19600	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C2I25_19615	COG0561	phosphatase activity
C2I25_19630	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2I25_19635	COG0022	dehydrogenase e1 component
C2I25_19680	COG1982	Orn Lys Arg decarboxylase major
C2I25_19700	COG0483	inositol monophosphate 1-phosphatase activity
C2I25_19725	COG4896	Protein conserved in bacteria
C2I25_19735	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C2I25_19740	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2I25_19750	COG0772	Belongs to the SEDS family
C2I25_19760	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C2I25_19795	COG3336	cytochrome c oxidase
C2I25_19810	COG2340	Cysteine-rich secretory protein family
C2I25_19825	COG0406	alpha-ribazole phosphatase activity
C2I25_19830	COG3679	Belongs to the UPF0342 family
C2I25_19845	COG0742	ribosomal rna small subunit methyltransferase
C2I25_19855	COG3314	Sporulation integral membrane protein YlbJ
C2I25_19860	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2I25_19865	COG3480	Lon protease (S16) C-terminal proteolytic domain
C2I25_19875	COG1399	metal-binding, possibly nucleic acid-binding protein
C2I25_19895	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2I25_19920	COG0768	penicillin binding
C2I25_19940	COG0772	Belongs to the SEDS family
C2I25_19945	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2I25_19960	COG0849	cell division
C2I25_19965	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C2I25_19975	COG1191	sigma factor activity
C2I25_19980	COG1191	sigma factor activity
C2I25_19985	COG1873	PFAM PRC-barrel domain
C2I25_19995	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2I25_20005	COG0762	integral membrane protein
C2I25_20010	COG2302	S4 RNA-binding domain
C2I25_20015	COG3599	regulation of cell shape
C2I25_20035	COG0564	pseudouridine synthase activity
C2I25_20100	COG3069	C4-dicarboxylate transmembrane transporter activity
C2I25_20120	COG0006	proline dipeptidase activity
C2I25_20135	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C2I25_20140	COG1561	YicC-like family, N-terminal region
C2I25_20160	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2I25_20165	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2I25_20180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2I25_20180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2I25_20190	COG0631	protein serine/threonine phosphatase activity
C2I25_20195	COG0515	serine threonine protein kinase
C2I25_20195	COG2815	serine threonine protein kinase
C2I25_20205	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2I25_20210	COG1564	THIamine pyrophosphokinase
C2I25_20225	COG1302	Protein conserved in bacteria
C2I25_20230	COG1461	Dihydroxyacetone kinase
C2I25_20235	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2I25_20250	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2I25_20255	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_20270	COG1196	nuclear chromosome segregation
C2I25_20275	COG0552	protein localization to endoplasmic reticulum
C2I25_20285	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2I25_20295	COG1837	Belongs to the UPF0109 family
C2I25_20335	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2I25_20340	COG0758	DNA mediated transformation
C2I25_20345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2I25_20355	COG4974	Belongs to the 'phage' integrase family
C2I25_20400	COG4589	Belongs to the CDS family
C2I25_20410	COG0750	zinc metalloprotease
C2I25_20435	COG0195	Participates in both transcription termination and antitermination
C2I25_20440	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C2I25_20445	COG1358	cellular component organization or biogenesis
C2I25_20455	COG1550	Protein conserved in bacteria
C2I25_20470	COG0196	riboflavin kinase activity
C2I25_20485	COG0726	polysaccharide deacetylase
C2I25_20490	COG0612	Peptidase, M16
C2I25_20495	COG1873	PFAM PRC-barrel domain
C2I25_20500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2I25_20505	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2I25_20510	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2I25_20515	COG0527	aspartate kinase activity
C2I25_20525	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C2I25_20530	COG0740	serine-type endopeptidase activity
C2I25_20550	COG2188	Transcriptional regulator
C2I25_20575	COG0612	Peptidase, M16
C2I25_20580	COG0612	Peptidase, M16
C2I25_20585	COG0300	oxidoreductase activity
C2I25_20600	COG1426	Protein conserved in bacteria
C2I25_20605	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2I25_20630	COG1692	metallophosphoesterase
C2I25_20635	COG2359	stage V sporulation protein S
C2I25_20645	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C2I25_20645	COG0674	pyruvate-flavodoxin oxidoreductase activity
C2I25_20650	COG1013	pyruvate-flavodoxin oxidoreductase activity
C2I25_20660	COG4550	Control of competence regulator ComK, YlbF/YmcA
C2I25_20685	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C2I25_20690	COG1368	sulfuric ester hydrolase activity
C2I25_20705	COG3773	Cell wall hydrolase
C2I25_20715	COG0823	Involved in the tonB-independent uptake of proteins
C2I25_20720	COG2723	6-phospho-beta-galactosidase activity
C2I25_20725	COG2188	Transcriptional regulator
C2I25_20735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I25_20745	COG1346	cytolysis
C2I25_20765	COG1086	Polysaccharide biosynthesis protein
C2I25_20785	COG3300	MHYT domain
C2I25_20785	COG5001	Diguanylate cyclase
C2I25_20790	COG2267	carboxylic ester hydrolase activity
C2I25_20805	COG2364	Membrane
C2I25_20815	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C2I25_20820	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2I25_20825	COG2169	Transcriptional regulator
C2I25_20830	COG0708	Exodeoxyribonuclease III
C2I25_20835	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2I25_20840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I25_20845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I25_20850	COG1120	ATPase activity
C2I25_20855	COG2819	hydrolase of the alpha beta superfamily
C2I25_20865	COG1937	Protein conserved in bacteria
C2I25_20870	COG2608	mercury ion transmembrane transporter activity
C2I25_20875	COG2217	Heavy metal translocating P-type atpase
C2I25_20890	COG2116	formate transmembrane transporter activity
C2I25_20895	COG1408	metallophosphoesterase
C2I25_20910	COG1113	amino acid transport
C2I25_20925	COG2322	membrane
C2I25_20930	COG1979	alcohol dehydrogenase
C2I25_20935	COG1349	DNA-binding transcription factor activity
C2I25_20940	COG1105	Belongs to the carbohydrate kinase PfkB family
C2I25_20945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2I25_20945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I25_20945	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2I25_20955	COG1388	LysM domain
C2I25_20955	COG3584	3D domain protein
C2I25_20985	COG0464	growth
C2I25_20990	COG2860	membrane
C2I25_20995	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2I25_21000	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
C2I25_21005	COG0789	Transcriptional regulator
C2I25_21010	COG0174	glutamine synthetase
C2I25_21015	COG1695	Transcriptional regulator
C2I25_21035	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2I25_21045	COG0737	Belongs to the 5'-nucleotidase family
C2I25_21085	COG1132	(ABC) transporter
C2I25_21090	COG1132	(ABC) transporter
C2I25_21115	COG0730	response to heat
C2I25_21130	COG1346	cytolysis
C2I25_21140	COG0583	DNA-binding transcription factor activity
C2I25_21155	COG1131	(ABC) transporter
C2I25_21180	COG0785	Cytochrome C biogenesis protein
C2I25_21185	COG4846	Membrane protein involved in cytochrome C biogenesis
C2I25_21215	COG2226	methyltransferase
C2I25_21240	COG0010	Belongs to the arginase family
C2I25_21245	COG1329	Transcriptional regulator
C2I25_21250	COG1902	pentaerythritol trinitrate reductase activity
C2I25_21255	COG0069	glutamate synthase activity
C2I25_21260	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2I25_21265	COG0346	lactoylglutathione lyase activity
C2I25_21270	COG0400	carboxylic ester hydrolase activity
C2I25_21275	COG5002	protein histidine kinase activity
C2I25_21290	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I25_21375	COG1131	(ABC) transporter
C2I25_21390	COG1136	(ABC) transporter
C2I25_21405	COG5002	protein histidine kinase activity
C2I25_21415	COG0318	PFAM AMP-dependent synthetase and ligase
C2I25_21420	COG1268	BioY protein
C2I25_21425	COG0318	PFAM AMP-dependent synthetase and ligase
C2I25_21430	COG0183	Belongs to the thiolase family
C2I25_21445	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2I25_21455	COG2211	Major facilitator Superfamily
C2I25_21475	COG0726	polysaccharide deacetylase
C2I25_21485	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C2I25_21490	COG2274	protein secretion by the type I secretion system
C2I25_21500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2I25_21525	COG0824	Thioesterase
C2I25_21530	COG4841	protein insertion into membrane
C2I25_21550	COG0745	RESPONSE REGULATOR receiver
C2I25_21555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2I25_21560	COG1832	CoA-binding protein
C2I25_21570	COG0187	DNA topoisomerase II activity
C2I25_21575	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C2I25_21580	COG0673	inositol 2-dehydrogenase activity
C2I25_21600	COG1131	(ABC) transporter
C2I25_21610	COG1595	DNA-templated transcription, initiation
C2I25_21620	COG1316	TRANSCRIPTIONal
C2I25_21625	COG4166	transmembrane transport
C2I25_21630	COG4166	transmembrane transport
C2I25_21645	COG4166	transmembrane transport
C2I25_21650	COG2226	methyltransferase
C2I25_21685	COG0531	amino acid
C2I25_21700	COG0697	spore germination
C2I25_21710	COG3383	formate dehydrogenase (NAD+) activity
C2I25_21715	COG2427	Protein of unknown function (DUF1641)
C2I25_21720	COG5609	conserved protein (DUF2294)
C2I25_21725	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C2I25_21740	COG2116	formate transmembrane transporter activity
C2I25_21745	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2I25_21750	COG0303	'Molybdopterin
C2I25_21755	COG0314	molybdopterin synthase activity
C2I25_21765	COG0489	protein tyrosine kinase activity
C2I25_21780	COG3326	Membrane
C2I25_21785	COG2962	Rard protein
C2I25_21790	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
C2I25_21795	COG1657	PFAM Prenyltransferase squalene oxidase
C2I25_21805	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_21810	COG1012	belongs to the aldehyde dehydrogenase family
C2I25_21820	COG4145	pantothenate transmembrane transporter activity
C2I25_21835	COG0165	Argininosuccinate lyase
C2I25_21845	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_21865	COG1051	belongs to the nudix hydrolase family
C2I25_21875	COG0716	FMN binding
C2I25_21885	COG1278	Cold shock
C2I25_21910	COG2720	vancomycin resistance protein
C2I25_21915	COG2514	catechol 2,3-dioxygenase activity
C2I25_21925	COG1285	pathogenesis
C2I25_21935	COG3852	Histidine kinase
C2I25_21960	COG1876	peptidase activity
C2I25_21975	COG1309	transcriptional regulator
C2I25_22020	COG0457	Tetratricopeptide repeat
C2I25_22035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2I25_22045	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C2I25_22065	COG0697	spore germination
C2I25_22080	COG3397	chitin binding
C2I25_22085	COG0823	Involved in the tonB-independent uptake of proteins
C2I25_22125	COG0584	glycerophosphoryl diester phosphodiesterase
C2I25_22140	COG1252	NADH dehydrogenase
C2I25_22145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2I25_22145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I25_22160	COG0277	FAD linked oxidase domain protein
C2I25_22180	COG2808	Putative FMN-binding domain
C2I25_22190	COG0457	Tetratricopeptide repeat
C2I25_22200	COG0604	alcohol dehydrogenase
C2I25_22205	COG0640	Transcriptional regulator
C2I25_22215	COG0584	glycerophosphoryl diester phosphodiesterase
C2I25_22240	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2I25_22255	COG3781	membrane
C2I25_22275	COG1164	Oligoendopeptidase f
C2I25_22280	COG2162	N-hydroxyarylamine O-acetyltransferase activity
C2I25_22315	COG0583	DNA-binding transcription factor activity
C2I25_22350	COG3739	integral membrane protein
C2I25_22355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I25_22360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I25_22365	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2I25_22380	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2I25_22385	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2I25_22430	COG2814	Major facilitator Superfamily
C2I25_22435	COG1113	amino acid transport
C2I25_22470	COG2072	flavoprotein involved in K transport
C2I25_22515	COG1151	hydroxylamine reductase activity
C2I25_22570	COG1280	lysine exporter protein (LysE YggA)
C2I25_22580	COG1191	sigma factor activity
C2I25_22590	COG0726	polysaccharide deacetylase
C2I25_22605	COG1733	regulation of RNA biosynthetic process
C2I25_22610	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2I25_22615	COG0318	PFAM AMP-dependent synthetase and ligase
C2I25_22630	COG0367	asparagine synthase
C2I25_22685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I25_22705	COG1733	regulation of RNA biosynthetic process
C2I25_22710	COG1733	regulation of RNA biosynthetic process
C2I25_22715	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2I25_22720	COG0673	inositol 2-dehydrogenase activity
C2I25_22725	COG2188	Transcriptional regulator
C2I25_22730	COG1733	regulation of RNA biosynthetic process
C2I25_22770	COG0814	amino acid
C2I25_22785	COG0659	secondary active sulfate transmembrane transporter activity
C2I25_22790	COG2824	Alkylphosphonate utilization operon protein PhnA
C2I25_22825	COG2814	Major facilitator Superfamily
C2I25_22830	COG0656	L-ascorbic acid biosynthetic process
C2I25_22845	COG1733	regulation of RNA biosynthetic process
C2I25_22850	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2I25_22850	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2I25_22855	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2I25_22855	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2I25_22880	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_22895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2I25_22900	COG0604	alcohol dehydrogenase
C2I25_22905	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C2I25_22910	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C2I25_22915	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2I25_22920	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C2I25_22935	COG1070	Carbohydrate kinase
C2I25_22940	COG2706	6-phosphogluconolactonase activity
C2I25_22945	COG3813	Protein conserved in bacteria
C2I25_22950	COG1357	PFAM Pentapeptide repeats (8 copies)
C2I25_22960	COG0697	spore germination
C2I25_22985	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C2I25_22995	COG0789	Transcriptional regulator
C2I25_23000	COG1253	flavin adenine dinucleotide binding
C2I25_23030	COG0477	Major facilitator Superfamily
C2I25_23040	COG0500	methyltransferase
C2I25_23070	COG0628	permease
C2I25_23085	COG0110	maltose O-acetyltransferase activity
C2I25_23090	COG0738	Major facilitator superfamily
C2I25_23095	COG1940	carbohydrate kinase activity
C2I25_23100	COG0346	lactoylglutathione lyase activity
C2I25_23135	COG1011	Hydrolase
C2I25_23165	COG1131	(ABC) transporter
C2I25_23175	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_23205	COG0778	Nitroreductase
C2I25_23210	COG1733	regulation of RNA biosynthetic process
C2I25_23230	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2I25_23250	COG2356	endonuclease I
C2I25_23255	COG1288	antiporter activity
C2I25_23310	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2I25_23320	COG2031	fatty acid transporter
C2I25_23340	COG1131	(ABC) transporter
C2I25_23345	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C2I25_23355	COG2814	Major facilitator Superfamily
C2I25_23360	COG1846	Transcriptional regulator
C2I25_23375	COG0477	Major facilitator Superfamily
C2I25_23385	COG2843	Capsule synthesis protein
C2I25_23390	COG1876	peptidase activity
C2I25_23410	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2I25_23410	COG3409	Peptidoglycan-binding domain 1 protein
C2I25_23435	COG2207	Transcriptional regulator
C2I25_23435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2I25_23445	COG0662	Cupin 2, conserved barrel domain protein
C2I25_23465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2I25_23485	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2I25_23495	COG4990	cell redox homeostasis
C2I25_23500	COG0745	RESPONSE REGULATOR receiver
C2I25_23505	COG5002	protein histidine kinase activity
C2I25_23510	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I25_23520	COG5002	protein histidine kinase activity
C2I25_23520	COG3850	Histidine kinase
C2I25_23540	COG0577	efflux transmembrane transporter activity
C2I25_23560	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C2I25_23570	COG1690	Belongs to the RtcB family
C2I25_23580	COG2309	aminopeptidase activity
C2I25_23595	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C2I25_23620	COG2814	Major facilitator Superfamily
C2I25_23665	COG1136	(ABC) transporter
C2I25_23705	COG5002	protein histidine kinase activity
C2I25_23705	COG3850	Histidine kinase
C2I25_23710	COG0745	RESPONSE REGULATOR receiver
C2I25_23750	COG1725	Transcriptional regulator
C2I25_23755	COG1131	(ABC) transporter
C2I25_23790	COG0583	DNA-binding transcription factor activity
C2I25_23795	COG0814	amino acid
C2I25_23830	COG0346	lactoylglutathione lyase activity
C2I25_23845	COG1522	sequence-specific DNA binding
C2I25_23850	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_23855	COG1309	transcriptional regulator
C2I25_23860	COG2814	Major facilitator Superfamily
C2I25_23870	COG3320	Male sterility
C2I25_23870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2I25_23890	COG2814	Major facilitator Superfamily
C2I25_23900	COG0640	Transcriptional regulator
C2I25_23905	COG0346	lactoylglutathione lyase activity
C2I25_23910	COG0798	PFAM Bile acid sodium symporter
C2I25_23920	COG1575	Belongs to the MenA family. Type 1 subfamily
C2I25_23930	COG0726	polysaccharide deacetylase
C2I25_23940	COG5609	conserved protein (DUF2294)
C2I25_23945	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2I25_23955	COG0288	reversible hydration of carbon dioxide
C2I25_23960	COG0415	Belongs to the DNA photolyase family
C2I25_23985	COG0814	amino acid
C2I25_24025	COG0598	Magnesium transport protein CorA
C2I25_24030	COG1846	Transcriptional regulator
C2I25_24035	COG0583	DNA-binding transcription factor activity
C2I25_24055	COG1335	isochorismatase
C2I25_24060	COG2267	carboxylic ester hydrolase activity
C2I25_24065	COG0737	Belongs to the 5'-nucleotidase family
C2I25_24085	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2I25_24095	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C2I25_24105	COG1063	alcohol dehydrogenase
C2I25_24125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I25_24130	COG3848	Pyruvate phosphate dikinase
C2I25_24130	COG0574	Belongs to the PEP-utilizing enzyme family
C2I25_24155	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
C2I25_24190	COG1960	acyl-CoA dehydrogenase activity
C2I25_24200	COG0640	Transcriptional regulator
C2I25_24215	COG1414	Transcriptional regulator
C2I25_24220	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C2I25_24225	COG1984	allophanate hydrolase subunit 2
C2I25_24290	COG4335	DNA alkylation repair
C2I25_24300	COG0833	amino acid
C2I25_24310	COG0730	response to heat
C2I25_24330	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C2I25_24330	COG0456	acetyltransferase
C2I25_24350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I25_24355	COG0697	spore germination
C2I25_24370	COG0456	acetyltransferase
C2I25_24395	COG4884	unkown
C2I25_24395	COG3831	ATPase activity
C2I25_24420	COG1846	Transcriptional regulator
C2I25_24425	COG0778	Nitroreductase
C2I25_24460	COG0753	catalase activity
C2I25_24465	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2I25_24485	COG0714	Associated with various cellular activities
C2I25_24510	COG0346	lactoylglutathione lyase activity
C2I25_24515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I25_24525	COG3279	Response regulator of the LytR AlgR family
C2I25_24535	COG4377	Putative membrane peptidase family (DUF2324)
C2I25_24555	COG3655	Transcriptional regulator
C2I25_24565	COG1785	Belongs to the alkaline phosphatase family
C2I25_24570	COG2720	vancomycin resistance protein
C2I25_24580	COG3239	Fatty acid desaturase
C2I25_24610	COG1414	Transcriptional regulator
C2I25_24615	COG4187	Peptidase family M20/M25/M40
C2I25_24620	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2I25_24640	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2I25_24655	COG2329	Antibiotic biosynthesis monooxygenase
C2I25_24680	COG1070	Carbohydrate kinase
C2I25_24685	COG2390	Transcriptional regulator
C2I25_24695	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2I25_24700	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2I25_24705	COG1879	ABC-type sugar transport system periplasmic component
C2I25_24730	COG0277	FAD linked oxidase domain protein
C2I25_24745	COG3584	3D domain protein
C2I25_24745	COG1388	LysM domain
C2I25_24795	COG1605	Chorismate mutase
C2I25_24795	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C2I25_24815	COG0287	Prephenate dehydrogenase
C2I25_24830	COG1309	transcriptional regulator
C2I25_24835	COG2409	Drug exporters of the RND superfamily
C2I25_24835	COG1033	growth of symbiont in host cell
C2I25_24840	COG0488	(ABC) transporter
C2I25_24845	COG1368	sulfuric ester hydrolase activity
C2I25_24850	COG0861	Integral membrane protein TerC family
C2I25_24860	COG0726	polysaccharide deacetylase
C2I25_24870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I25_24875	COG0346	lactoylglutathione lyase activity
C2I25_24880	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2I25_24885	COG4912	Dna alkylation repair
C2I25_24905	COG2318	DinB family
C2I25_24915	COG0697	spore germination
C2I25_24925	COG2746	aminoglycoside 3-N-acetyltransferase activity
C2I25_24965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2I25_24970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2I25_24975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2I25_24990	COG0628	permease
C2I25_25045	COG1131	(ABC) transporter
C2I25_25065	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C2I25_25075	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2I25_25080	COG0436	Aminotransferase
C2I25_25120	COG2226	methyltransferase
C2I25_25135	COG2261	transglycosylase associated protein
C2I25_25160	COG0477	Major facilitator Superfamily
C2I25_25160	COG2814	Major facilitator Superfamily
C2I25_25165	COG4533	DNA binding
C2I25_25170	COG0789	Transcriptional regulator
C2I25_25175	COG1664	Polymer-forming cytoskeletal
C2I25_25185	COG2814	Major facilitator Superfamily
C2I25_25230	COG1307	EDD domain protein, DegV family
C2I25_25235	COG1164	Oligoendopeptidase f
C2I25_25270	COG0745	RESPONSE REGULATOR receiver
C2I25_25275	COG5002	protein histidine kinase activity
C2I25_25275	COG3850	Histidine kinase
C2I25_25320	COG0667	Aldo Keto reductase
C2I25_25335	COG4948	Mandelate Racemase Muconate Lactonizing
C2I25_25345	COG4166	transmembrane transport
C2I25_25350	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
C2I25_25360	COG0586	Pfam SNARE associated Golgi protein
C2I25_25405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2I25_25410	COG3938	Belongs to the proline racemase family
C2I25_25420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2I25_25425	COG1012	belongs to the aldehyde dehydrogenase family
C2I25_25430	COG1115	amino acid carrier protein
C2I25_25435	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2I25_25450	COG3397	chitin binding
C2I25_25475	COG4637	Psort location Cytoplasmic, score
C2I25_25510	COG0514	ATP-dependent DNA helicase (RecQ)
C2I25_25530	COG3973	AAA domain
C2I25_25575	COG2315	Protein conserved in bacteria
C2I25_25585	COG2205	protein histidine kinase activity
C2I25_25600	COG1819	glycosyl
C2I25_25605	COG3397	chitin binding
C2I25_25610	COG2153	protein acetylation
C2I25_25640	COG0517	IMP dehydrogenase activity
C2I25_25640	COG4175	Glycine betaine
C2I25_25645	COG4176	ABC-type proline glycine betaine transport system permease component
C2I25_25685	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C2I25_25685	COG0456	acetyltransferase
C2I25_25690	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_25700	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2I25_25705	COG0022	dehydrogenase e1 component
C2I25_25710	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2I25_25715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2I25_25730	COG1959	2 iron, 2 sulfur cluster binding
C2I25_25745	COG1349	DNA-binding transcription factor activity
C2I25_25765	COG3284	Transcriptional regulator
C2I25_25795	COG1309	transcriptional regulator
C2I25_25830	COG3773	Cell wall hydrolase
C2I25_25830	COG3409	Peptidoglycan-binding domain 1 protein
C2I25_25835	COG2959	enzyme of heme biosynthesis
C2I25_25850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I25_25880	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C2I25_25890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I25_25895	COG0697	spore germination
C2I25_25900	COG0201	protein transport
C2I25_25915	COG0737	Belongs to the 5'-nucleotidase family
C2I25_25920	COG3227	Zinc metalloprotease (Elastase)
C2I25_25925	COG1523	belongs to the glycosyl hydrolase 13 family
C2I25_25940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I25_25945	COG1073	alpha beta
C2I25_25950	COG0577	efflux transmembrane transporter activity
C2I25_25955	COG1136	(ABC) transporter
C2I25_25970	COG5002	protein histidine kinase activity
C2I25_25975	COG0745	RESPONSE REGULATOR receiver
C2I25_26005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2I25_26045	COG0322	excinuclease ABC activity
C2I25_26085	COG4667	esterase of the alpha-beta hydrolase superfamily
C2I25_26110	COG3878	Protein conserved in bacteria
C2I25_26115	COG0251	oxidation-reduction process
C2I25_26140	COG0592	DNA-directed DNA polymerase activity
C2I25_26160	COG2223	nitrite transmembrane transporter activity
C2I25_26205	COG0697	spore germination
C2I25_26210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I25_26230	COG0584	glycerophosphoryl diester phosphodiesterase
C2I25_26255	COG0789	Transcriptional regulator
C2I25_26255	COG4978	Transcriptional regulator
C2I25_26260	COG2814	Major facilitator Superfamily
C2I25_26315	COG0671	phosphoesterase, PA-phosphatase related
C2I25_26320	COG0604	alcohol dehydrogenase
C2I25_26385	COG2205	protein histidine kinase activity
C2I25_26410	COG1794	racemase activity, acting on amino acids and derivatives
C2I25_26415	COG1819	glycosyl
C2I25_26430	COG5002	protein histidine kinase activity
C2I25_26435	COG0561	phosphatase activity
C2I25_26475	COG2124	cytochrome p450
C2I25_26535	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2I25_26535	COG3409	Peptidoglycan-binding domain 1 protein
C2I25_26535	COG1388	LysM domain
C2I25_26540	COG4824	toxin secretion phage lysis holin
C2I25_26595	COG0740	serine-type endopeptidase activity
C2I25_26610	COG5484	DNA packaging
C2I25_26650	COG0582	viral genome integration into host DNA
C2I25_26705	COG2002	toxin-antitoxin pair type II binding
C2I25_26725	COG1396	sequence-specific DNA binding
C2I25_26745	COG0582	viral genome integration into host DNA
C2I25_26775	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C2I25_26785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I25_26790	COG0460	homoserine dehydrogenase
C2I25_26810	COG0577	efflux transmembrane transporter activity
C2I25_26815	COG1136	(ABC) transporter
C2I25_26835	COG2205	protein histidine kinase activity
C2I25_26840	COG0745	RESPONSE REGULATOR receiver
C2I25_26850	COG3773	Cell wall hydrolase
C2I25_26865	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2I25_26870	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2I25_26875	COG2323	membrane
C2I25_26895	COG2368	4-hydroxyphenylacetate
C2I25_26905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I25_26950	COG1733	regulation of RNA biosynthetic process
C2I25_26955	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_26980	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C2I25_27010	COG2207	Transcriptional regulator
C2I25_27015	COG3227	Zinc metalloprotease (Elastase)
C2I25_27035	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2I25_27065	COG1686	Belongs to the peptidase S11 family
C2I25_27085	COG0572	uridine kinase
C2I25_27105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2I25_27110	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2I25_27115	COG1024	Enoyl-CoA hydratase
C2I25_27120	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2I25_27125	COG0511	ligase activity, forming carbon-carbon bonds
C2I25_27130	COG0439	Biotin carboxylase
C2I25_27135	COG1960	acyl-CoA dehydrogenase activity
C2I25_27150	COG1309	transcriptional regulator
C2I25_27160	COG1131	(ABC) transporter
C2I25_27170	COG1408	metallophosphoesterase
C2I25_27180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I25_27205	COG1595	DNA-templated transcription, initiation
C2I25_27210	COG0768	penicillin binding
C2I25_27265	COG2267	carboxylic ester hydrolase activity
C2I25_27275	COG5002	protein histidine kinase activity
C2I25_27300	COG2207	Transcriptional regulator
C2I25_27325	COG0322	excinuclease ABC activity
C2I25_27330	COG0531	amino acid
C2I25_27335	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2I25_27345	COG0531	amino acid
C2I25_27350	COG0697	spore germination
C2I25_27365	COG0784	Response regulator, receiver
C2I25_27370	COG4191	Histidine kinase
C2I25_27380	COG1115	amino acid carrier protein
C2I25_27420	COG2814	Major facilitator Superfamily
C2I25_27435	COG1686	Belongs to the peptidase S11 family
C2I25_27440	COG0110	maltose O-acetyltransferase activity
C2I25_27445	COG0730	response to heat
C2I25_27455	COG2002	toxin-antitoxin pair type II binding
C2I25_27490	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2I25_27545	COG1846	Transcriptional regulator
C2I25_27550	COG3961	Belongs to the TPP enzyme family
C2I25_27565	COG0500	methyltransferase
C2I25_27565	COG3615	Tellurite resistance protein tehB
C2I25_27605	COG2002	toxin-antitoxin pair type II binding
C2I25_27625	COG0582	viral genome integration into host DNA
C2I25_27650	COG1309	transcriptional regulator
C2I25_27675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I25_27690	COG1846	Transcriptional regulator
C2I25_27710	COG2971	BadF BadG BcrA BcrD
C2I25_27735	COG1649	PFAM Uncharacterised BCR, COG1649
C2I25_27765	COG1595	DNA-templated transcription, initiation
C2I25_27770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2I25_27805	COG1396	sequence-specific DNA binding
C2I25_27840	COG1132	(ABC) transporter
C2I25_27845	COG1132	(ABC) transporter
C2I25_27860	COG2258	MOSC domain
C2I25_27865	COG0583	DNA-binding transcription factor activity
C2I25_27885	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2I25_27890	COG0583	DNA-binding transcription factor activity
C2I25_27900	COG0561	phosphatase activity
C2I25_27925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I25_27960	COG1247	-acetyltransferase
C2I25_27995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I25_28010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2I25_28050	COG0028	Belongs to the TPP enzyme family
C2I25_28065	COG2814	Major facilitator Superfamily
C2I25_28075	COG1136	(ABC) transporter
C2I25_28080	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2I25_28085	COG1187	pseudouridine synthase activity
C2I25_28105	COG1115	amino acid carrier protein
C2I25_28115	COG2318	DinB family
C2I25_28125	COG0776	regulation of translation
C2I25_28140	COG2814	Major facilitator Superfamily
C2I25_28145	COG3251	PFAM MbtH domain protein
C2I25_28150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2I25_28155	COG1535	isochorismatase
C2I25_28155	COG3433	isochorismatase activity
C2I25_28160	COG1021	2,3-dihydroxybenzoate-AMP ligase
C2I25_28165	COG1169	isochorismate synthase
C2I25_28170	COG1028	Short-chain dehydrogenase reductase Sdr
C2I25_28180	COG2223	nitrite transmembrane transporter activity
C2I25_28205	COG0419	ATPase involved in DNA repair
C2I25_28210	COG0420	3'-5' exonuclease activity
C2I25_28225	COG1024	Enoyl-CoA hydratase
C2I25_28230	COG1280	lysine exporter protein (LysE YggA)
C2I25_28240	COG2084	Dehydrogenase
C2I25_28245	COG1960	acyl-CoA dehydrogenase activity
C2I25_28250	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C2I25_28255	COG2079	MmgE PrpD family protein
C2I25_28260	COG0372	Belongs to the citrate synthase family
C2I25_28265	COG4841	protein insertion into membrane
C2I25_28270	COG2814	Major facilitator Superfamily
C2I25_28280	COG4499	WXG100 protein secretion system (Wss), protein YukC
C2I25_28280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2I25_28300	COG0300	oxidoreductase activity
C2I25_28390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2I25_28395	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C2I25_28400	COG0671	phosphoesterase, PA-phosphatase related
C2I25_28410	COG4991	sh3 domain protein
C2I25_28410	COG3064	Membrane
C2I25_28410	COG0515	serine threonine protein kinase
C2I25_28445	COG1509	lysine 2,3-aminomutase activity
C2I25_28450	COG3829	transcription factor binding
C2I25_28455	COG0456	acetyltransferase
C2I25_28460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2I25_28465	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2I25_28470	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C2I25_28475	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2I25_28490	COG5506	Protein of unknown function (DUF1694)
C2I25_28495	COG1012	belongs to the aldehyde dehydrogenase family
C2I25_28500	COG1253	flavin adenine dinucleotide binding
C2I25_28535	COG5506	Protein of unknown function (DUF1694)
C2I25_28540	COG1012	belongs to the aldehyde dehydrogenase family
C2I25_28545	COG1253	flavin adenine dinucleotide binding
C2I25_28580	COG1174	glycine betaine transport