locus-tag class description HLB41_00010 ENOG4105W42 Veg protein HLB41_00015 ENOG4105XFA sporulation peptidase YabG HLB41_00025 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) HLB41_00030 ENOG4105F8V Hydrolase, tatD family HLB41_00035 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HLB41_00040 ENOG4105KRN Transcriptional regulator, abrb family HLB41_00045 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HLB41_00055 ENOG41060K3 Methyltransferase HLB41_00065 ENOG4105MA4 psp1 domain protein HLB41_00070 ENOG4105FA2 dna polymerase iii HLB41_00080 ENOG4105CXN decarboxylase HLB41_00115 ENOG41067KS pro-sigma K processing HLB41_00135 ENOG4105C6E dna polymerase iii HLB41_00145 ENOG4108Z6B deaminase HLB41_00150 ENOG4105GTG Isochorismatase HLB41_00160 ENOG4105ZMH deoxynucleoside kinase HLB41_00195 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HLB41_00230 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HLB41_00245 ENOG410848D S4 domain protein YaaA HLB41_00250 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HLB41_00270 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HLB41_00280 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HLB41_00285 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HLB41_00300 ENOG4107QJE Chromosome Partitioning Protein HLB41_00305 ENOG4105FA0 parb-like partition protein HLB41_00310 ENOG4108ZDA Sporulation protein YyaC HLB41_00315 ENOG4105D8X mechanosensitive ion channel HLB41_00320 ENOG4105VDK protein, conserved in bacteria HLB41_00325 ENOG4105C3G gtp-binding protein HLB41_00335 ENOG4108UUM single-stranded DNA-binding protein HLB41_00345 ENOG4108XMW Membrane HLB41_00350 ENOG4105BZR domain protein HLB41_00360 ENOG4105CDU Replicative dna helicase HLB41_00365 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HLB41_00390 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLB41_00395 ENOG4105BZU Histidine kinase HLB41_00410 ENOG4105Q2H domain protein HLB41_00415 ENOG4105C0H protease HLB41_00425 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HLB41_00430 ENOG4105BZU Histidine kinase HLB41_00440 ENOG4105DPN Oligoendopeptidase f HLB41_00445 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) HLB41_00450 ENOG4105C1J atp-dependent rna helicase HLB41_00460 ENOG4108UT2 hemolysin iii HLB41_00465 ENOG4105CMR udp-glucose 4-epimerase HLB41_00470 ENOG4105IW1 AmiS UreI transporter HLB41_00480 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HLB41_00495 ENOG4107RGD Major Facilitator superfamily HLB41_00500 ENOG4108HRK Histidine kinase HLB41_00505 ENOG4108NEV two component transcriptional regulator, LytTR family HLB41_00520 ENOG4106F5Q Membrane HLB41_00525 ENOG4105E0X reductase HLB41_00535 ENOG41067SE Tetr family transcriptional regulator HLB41_00540 ENOG4105C5H ABC transporter HLB41_00545 ENOG4105CKK Glycosyl transferase, family 2 HLB41_00550 ENOG4105EJV Membrane HLB41_00560 ENOG4105K64 Glycosyl transferase, family 2 HLB41_00570 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HLB41_00575 ENOG4108S4H thioesterase Superfamily protein HLB41_00585 ENOG4106YBV Methyl-accepting chemotaxis HLB41_00590 ENOG4105EN6 Membrane HLB41_00600 ENOG4105CG5 Glycosyl transferase (Group 1 HLB41_00610 ENOG41079KZ Major Facilitator Superfamily HLB41_00615 ENOG4105DY9 regulatoR HLB41_00620 ENOG4105D22 carbon starvation protein HLB41_00625 ENOG4105VCD cytoplasmic protein HLB41_00630 ENOG4105BZU Histidine kinase HLB41_00635 ENOG4105DWF phosphomethylpyrimidine kinase HLB41_00640 ENOG4105BZU Histidine kinase HLB41_00645 ENOG4105WH1 Two component transcriptional regulator luxr family HLB41_00655 ENOG4108Y4K DNA-binding transcriptional activator HLB41_00680 ENOG4105D6E homoserine dehydrogenase HLB41_00695 ENOG41090WU lipolytic protein G-D-S-L family HLB41_00700 ENOG4105CJ1 ABC, transporter HLB41_00705 ENOG4108TU7 Inherit from COG: (ABC) transporter HLB41_00715 ENOG4105VCH membrane HLB41_00720 ENOG410667J hydrolase HLB41_00730 ENOG4107SVH Potassium channel protein HLB41_00750 ENOG4108VKI Cell wall hydrolase HLB41_00765 ENOG4108IJ2 phosphate acetyltransferase HLB41_00770 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) HLB41_00775 ENOG4108VCI transcription factor, rsfa family HLB41_00785 ENOG4105DQ5 transport system permease protein HLB41_00790 ENOG4105EHG Permease protein HLB41_00795 ENOG4105E0A ABC, transporter HLB41_00800 ENOG4108MES Periplasmic binding protein HLB41_00805 ENOG4105DCI Phosphohydrolase HLB41_00810 ENOG41069HH 4-oxalocrotonate tautomerase HLB41_00815 ENOG4108Z4T Peptidase M50 HLB41_00820 ENOG4108XFG YwhD family HLB41_00825 ENOG4105BZ4 penicillin-binding protein HLB41_00830 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HLB41_00835 ENOG4107SWG transcriptional regulator MERR family HLB41_00840 ENOG4105DXB Major Facilitator superfamily HLB41_00850 ENOG4105CYW agmatinase HLB41_00870 ENOG410684U Domain of unknown function (DUF1934) HLB41_00880 ENOG4105DU6 RNA polymerase HLB41_00900 ENOG4105IIU Aminopeptidase HLB41_00910 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) HLB41_00915 ENOG4108M15 ABC transporter HLB41_00920 ENOG4105KCT ABC transporter HLB41_00925 ENOG4105BZU Histidine kinase HLB41_00935 ENOG4105D4Y metalloprotease HLB41_00950 ENOG4105BZU Histidine kinase HLB41_00965 ENOG4105DF6 Fe-S oxidoreductase HLB41_00975 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HLB41_00980 ENOG4105C1G acyl-Coa dehydrogenase HLB41_00985 ENOG4105C1G acyl-Coa dehydrogenase HLB41_01000 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HLB41_01020 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HLB41_01025 ENOG4105CBT Fructose-1,6-bisphosphatase HLB41_01030 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HLB41_01040 ENOG4107104 thymidine kinase HLB41_01045 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HLB41_01050 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HLB41_01055 ENOG4108ZXQ stage ii sporulation protein r HLB41_01065 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HLB41_01080 ENOG4107XC4 flavin reductase domain protein, FMN-binding HLB41_01085 ENOG4108VGI doxx family HLB41_01100 ENOG4108YZG isomerase HLB41_01105 ENOG4108UIC UPF0340 protein HLB41_01110 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HLB41_01130 ENOG41062M3 atp synthase HLB41_01135 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) HLB41_01185 ENOG4105BZU Histidine kinase HLB41_01190 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HLB41_01200 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HLB41_01205 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HLB41_01230 ENOG4105D65 subunit l HLB41_01235 ENOG4105C8S subunit m HLB41_01240 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HLB41_01245 ENOG4106778 Protein of unknown function (DUF1146) HLB41_01265 ENOG4108IUW ABC transporter HLB41_01280 ENOG4105FRN stage II sporulation protein HLB41_01290 ENOG4105MT0 Sporulation transcriptional regulator spoiiid HLB41_01305 ENOG4107YJ4 chain length determinant protein HLB41_01310 ENOG4105HTX biosynthesis protein HLB41_01315 ENOG4107YJ4 chain length determinant protein HLB41_01320 ENOG4108RB3 Capsular polysaccharide biosynthesis protein HLB41_01325 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HLB41_01330 ENOG4105D3Q Sugar transferase HLB41_01335 ENOG4105K64 Glycosyl transferase, family 2 HLB41_01350 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family HLB41_01355 ENOG4105H93 Acyltransferase family HLB41_01365 ENOG4107STW synthase HLB41_01370 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HLB41_01375 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HLB41_01385 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HLB41_01390 ENOG4108KGH TRANSCRIPTIONal HLB41_01400 ENOG4105CMR udp-glucose 4-epimerase HLB41_01405 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLB41_01410 ENOG4105BZU Histidine kinase HLB41_01425 ENOG4105CXY transporter HLB41_01435 ENOG4105C19 ABC transporter HLB41_01440 ENOG4107RBB ABC transporter, permease HLB41_01450 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HLB41_01480 ENOG4105C0D helicase HLB41_01485 ENOG4105KBK Zinc finger, swim domain protein HLB41_01510 ENOG41069ER domain protein HLB41_01515 ENOG4105C94 Transporter HLB41_01520 ENOG4107R8N Glycosyl transferase, family 2 HLB41_01535 ENOG4105K4H Nlp p60 protein HLB41_01545 ENOG4105E0M Sulfatase HLB41_01555 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) HLB41_01565 ENOG4105DAA L-lactate HLB41_01570 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HLB41_01600 ENOG4107RSM transcriptional regulator HLB41_01605 ENOG4105ECB domain protein HLB41_01640 ENOG4105VZJ PTS System HLB41_01650 ENOG4105VCP PTS System HLB41_01655 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HLB41_01660 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HLB41_01670 ENOG4105CK1 PTS System HLB41_01675 ENOG4105VCP PTS System HLB41_01680 ENOG4105F8D glycoside hydrolase family 4 HLB41_01700 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HLB41_01710 ENOG4105ESV Glycosyl transferase, family 4 HLB41_01715 ENOG4105C6Y Udp-glucose 6-dehydrogenase HLB41_01720 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HLB41_01725 ENOG4108KGH TRANSCRIPTIONal HLB41_01730 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HLB41_01740 ENOG4105KVH Transcriptional regulator HLB41_01745 ENOG4105K4H Nlp p60 protein HLB41_01755 ENOG41081UC Inherit from COG: Competence protein HLB41_01760 ENOG4105VEQ Cold shock protein HLB41_01765 ENOG4105MS2 ribosomal subunit Interface protein HLB41_01795 ENOG4108RDQ ABC transporter HLB41_01820 ENOG4105CAK Cell division ATP-binding protein ftsE HLB41_01825 ENOG4105CRP Part of the ABC transporter FtsEX involved in HLB41_01830 ENOG4105CN1 protease HLB41_01840 ENOG4105BZ1 (ABC) transporter HLB41_01855 ENOG4108WS4 fmn reductase HLB41_01865 ENOG4105DUM transcriptional regulator, lysR family HLB41_01870 ENOG4105HMI Membrane HLB41_01885 ENOG4107TXC Transcriptional regulator HLB41_01900 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HLB41_01905 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HLB41_01910 ENOG41086DT Membrane protein of unknown function HLB41_01920 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HLB41_01930 ENOG4108S4C acetyltransferase HLB41_01940 ENOG4105C3M thioredoxin reductase HLB41_01950 ENOG4108Z4K mutator MutT protein HLB41_01960 ENOG4105CHW UPF0052 protein HLB41_01970 ENOG4105KRI phosphocarrier protein (HPr HLB41_01980 ENOG4108QY0 Membrane HLB41_01995 ENOG4105CZ3 stage V sporulation protein ad HLB41_02000 ENOG41090VF Stage v sporulation protein ac HLB41_02025 ENOG4105BZU Histidine kinase HLB41_02030 ENOG4108IUX (ABC) transporter HLB41_02035 ENOG4105RHA ABC transporter, permease HLB41_02045 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HLB41_02095 ENOG41067MG lrgb family HLB41_02100 ENOG4105XZU Preprotein translocase, subunit SecG HLB41_02110 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HLB41_02125 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLB41_02140 ENOG4105CM4 permease protein HLB41_02145 ENOG4108IPW abc transporter atp-binding protein HLB41_02185 ENOG4108MK9 spermidine N(1)-acetyltransferase HLB41_02190 ENOG4105C5H ABC transporter HLB41_02210 ENOG4105WMR Protein CrcB homolog HLB41_02215 ENOG4105WMR Protein CrcB homolog HLB41_02235 ENOG4105D4A Cell wall formation (By similarity) HLB41_02240 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HLB41_02255 ENOG4105KVH Transcriptional regulator HLB41_02260 ENOG4105F27 Major Facilitator HLB41_02265 ENOG4105CV8 reductase HLB41_02280 ENOG4108RYK Nad-dependent epimerase dehydratase HLB41_02295 ENOG4105D9N nucleoside HLB41_02300 ENOG4105D9N nucleoside HLB41_02310 ENOG41090A1 ferritin HLB41_02320 ENOG4108URH decarboxylase HLB41_02335 ENOG4108RMU ferritin dps family protein HLB41_02345 ENOG4105NCW Trka-c domain protein HLB41_02350 ENOG4107S91 Sodium hydrogen exchanger HLB41_02355 ENOG4107T5V SNARE associated Golgi HLB41_02375 ENOG4105D4Y metalloprotease HLB41_02380 ENOG4105VG1 fes assembly suf system protein HLB41_02385 ENOG4105C8Q Methyl-accepting chemotaxis HLB41_02410 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HLB41_02425 ENOG4105BZU Histidine kinase HLB41_02430 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLB41_02435 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HLB41_02445 ENOG4107ZTW SNARE associated Golgi HLB41_02485 ENOG4107AYK membrAne HLB41_02495 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HLB41_02515 ENOG4107R7I amino acid HLB41_02525 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) HLB41_02530 ENOG4108SUT Major Facilitator Superfamily HLB41_02545 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HLB41_02565 ENOG4105DZ1 carboxypeptidase HLB41_02580 ENOG4105CHU acetyl-coa acetyltransferase HLB41_02585 ENOG4105C1G acyl-Coa dehydrogenase HLB41_02590 ENOG4108W8B Beta-lactamase domain protein HLB41_02615 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HLB41_02635 ENOG41080E8 Transcriptional regulator, Spx MgsR family HLB41_02660 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HLB41_02665 ENOG4108UMI ABC transporter, permease HLB41_02670 ENOG4105D01 (LipO)protein HLB41_02675 ENOG4105D01 (LipO)protein HLB41_02680 ENOG4105C3K feS assembly ATPase SufC HLB41_02685 ENOG4105JRK feS assembly protein SufD HLB41_02690 ENOG4105C9B Cysteine desulfurase HLB41_02695 ENOG4108UNV SUF system FeS assembly protein, NifU family HLB41_02700 ENOG4105DIW FeS assembly protein SUFB HLB41_02705 ENOG4107R8B 5'-nucleotidase HLB41_02710 ENOG4105KZD Domain of unknown function (DUF1805) HLB41_02715 ENOG4108YTE sporulation protein YunB HLB41_02720 ENOG4105FAA peptidase M23 HLB41_02745 ENOG41090T1 Membrane HLB41_02750 ENOG4107TXC Transcriptional regulator HLB41_02755 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) HLB41_02760 ENOG4105MMD transcriptional regulator HLB41_02780 ENOG4105CBT Fructose-1,6-bisphosphatase HLB41_02795 ENOG4105D4U had-superfamily hydrolase, subfamily iia HLB41_02805 ENOG4105DYS nad(p)h dehydrogenase (quinone) HLB41_02815 ENOG4108W5N phosphatidylglycerophosphatase a HLB41_02830 ENOG41083MR nifu domain-containing protein HLB41_02875 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HLB41_02880 ENOG4105C4B ABC transporter, permease HLB41_02885 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HLB41_02910 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HLB41_02930 ENOG4105EWC Purine nucleoside phosphorylase HLB41_02960 ENOG4105CEP NADH dehydrogenase HLB41_02975 ENOG41069ER domain protein HLB41_02980 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HLB41_02985 ENOG4106YN8 Prenyltransferase HLB41_02990 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) HLB41_03015 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HLB41_03030 ENOG4105KA0 thioesterase Superfamily protein HLB41_03050 ENOG4107R3E Citrate transporter HLB41_03060 ENOG4105Y38 Kinase-associated protein B HLB41_03075 ENOG4105C87 Aminotransferase class I and II HLB41_03085 ENOG4108MUZ hydrolase HLB41_03090 ENOG4105C5I Dehydrogenase HLB41_03095 ENOG4108ZB6 transcriptional regulator AsnC family HLB41_03100 ENOG4105CHM Aminotransferase HLB41_03110 ENOG4105WG9 Conserved Protein HLB41_03125 ENOG4107PBV potassium channel HLB41_03130 ENOG4105KT7 mgtC SapB transporter HLB41_03165 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HLB41_03265 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HLB41_03280 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HLB41_03315 ENOG4105VEQ Cold shock protein HLB41_03325 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HLB41_03330 ENOG4105E4F Isochorismate synthase HLB41_03335 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HLB41_03340 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HLB41_03345 ENOG4108IPT Naphthoate synthase HLB41_03350 ENOG4105CEY Amp-dependent synthetase and ligase HLB41_03355 ENOG4105DTQ mandelate racemase muconate lactonizing HLB41_03375 ENOG41069H0 dihydroorotase EC 3.5.2.3 HLB41_03400 ENOG4105C6Z Gluconate HLB41_03450 ENOG41082BM Transcriptional regulator, arsr family HLB41_03460 ENOG41086D8 Transcriptional regulator HLB41_03465 ENOG4105C19 ABC transporter HLB41_03480 ENOG4107ZTW SNARE associated Golgi HLB41_03495 ENOG4105C19 ABC transporter HLB41_03540 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) HLB41_03545 ENOG4108UGV hypoxanthine phosphoribosyltransferase HLB41_03570 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLB41_03575 ENOG4105BZU Histidine kinase HLB41_03605 ENOG41087YS Phage shock protein A HLB41_03640 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HLB41_03645 ENOG4105C4M (Ubiquinol oxidase) subunit I HLB41_03650 ENOG4108V2W Carbonate dehydratase HLB41_03715 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component HLB41_03725 ENOG4105D2X ABC transporter substrate-binding protein HLB41_03740 ENOG4107T7U Sulfatase HLB41_03745 ENOG4107S9D Alpha beta hydrolase HLB41_03755 ENOG4105CH6 catalase HLB41_03760 ENOG4105BZU Histidine kinase HLB41_03765 ENOG4105BZU Histidine kinase HLB41_03810 ENOG4108MK9 spermidine N(1)-acetyltransferase HLB41_03820 ENOG4105EPU Molybdenum cofactor synthesis domain protein HLB41_03830 ENOG4105BZF Glycosyl transferase (Group 1 HLB41_03835 ENOG4105YVM Phosphoesterase, PA-phosphatase related HLB41_03840 ENOG4108Z0R Transferase HLB41_03845 ENOG4105E8V Alpha Beta Hydrolase Fold protein HLB41_03870 ENOG4105CIG ABC transporter HLB41_03880 ENOG4105N5T Radical SAM Protein HLB41_03900 ENOG4105C19 ABC transporter HLB41_03915 ENOG4105NCW Trka-c domain protein HLB41_03920 ENOG4107S91 Sodium hydrogen exchanger HLB41_03925 ENOG410605W Major Facilitator HLB41_03930 ENOG4105C8T Leucyl-tRNA synthetase HLB41_03955 ENOG4108B31 Spore germination protein HLB41_03965 ENOG4105DWV Homoserine O-trans-acetylase HLB41_03975 ENOG41085GJ domain protein HLB41_04000 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HLB41_04005 ENOG4105D06 uba thif-type nad fad binding protein HLB41_04015 ENOG4105CVM Molybdenum cofactor synthesis domain protein HLB41_04020 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein HLB41_04025 ENOG4108ZAF Molybdopterin HLB41_04040 ENOG4105CSC Glucose uptake protein HLB41_04045 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HLB41_04050 ENOG4108VJ1 Transcriptional regulator (CarD family HLB41_04085 ENOG4105CBX hi0933 family HLB41_04100 ENOG4105YW5 deoR family transcriptional regulator HLB41_04105 ENOG4107QSE Dipeptidase HLB41_04115 ENOG4108IUM Glycogen debranching enzyme HLB41_04120 ENOG4108V15 phosphotransferase enzyme family HLB41_04135 ENOG4105C8F Beta-lactamase domain protein HLB41_04165 ENOG4108VDD TRNA binding domain protein HLB41_04175 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HLB41_04220 ENOG4105C88 aminopeptidase HLB41_04240 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HLB41_04245 ENOG4105ETE Transcriptional regulator (LacI family HLB41_04275 ENOG4105EP9 oxidoreductase HLB41_04280 ENOG4107SNB ankyrin repeat protein YahD HLB41_04290 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HLB41_04305 ENOG4105DGU Histone deacetylase HLB41_04310 ENOG4105W87 Cbs domain HLB41_04315 ENOG4105F1V Acetoin utilization protein HLB41_04325 ENOG4108UW5 maltose o-acetyltransferase HLB41_04350 ENOG4108IBT Inherit from COG: transposase HLB41_04360 ENOG4105C28 cystathionine HLB41_04370 ENOG4105U5Y Transcriptional regulator HLB41_04380 ENOG4105RQF LysR family Transcriptional regulator HLB41_04405 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HLB41_04415 ENOG4105EFZ amidohydrolase HLB41_04430 ENOG4105KBJ sporulation protein ytfj HLB41_04435 ENOG4106F1P AAA ATPase, central domain protein HLB41_04440 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HLB41_04450 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HLB41_04470 ENOG4108JYZ YitT family HLB41_04490 ENOG4105CH7 arginosuccinase HLB41_04510 ENOG4107YZX Universal stress protein HLB41_04530 ENOG41082W1 Cupin 2, conserved barrel domain protein HLB41_04535 ENOG4105Z7P Acetyltransferase (GNAT) family HLB41_04570 ENOG4105DC7 peptidase M24 HLB41_04575 ENOG4105E8R UPF0173 metal-dependent hydrolase HLB41_04600 ENOG4105SFS phosphoesterase RecJ domain protein HLB41_04610 ENOG4105VV2 HLB41_04615 ENOG4105C0B DNA polymerase III (alpha subunit) HLB41_04620 ENOG4105C6K Malic enzyme HLB41_04625 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HLB41_04650 ENOG4105FS0 cytoplasmic membrane protein HLB41_04655 ENOG4108REF Sporulation integral membrane protein ytvi HLB41_04665 ENOG4105BZN citrate synthase HLB41_04670 ENOG4108HMX isocitrate dehydrogenase (NADP) HLB41_04675 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HLB41_04690 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HLB41_04695 ENOG4105BZU Histidine kinase HLB41_04700 ENOG4105C2M dna polymerase I HLB41_04705 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HLB41_04715 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HLB41_04720 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HLB41_04750 ENOG4108TDW sporulation protein YtxC HLB41_04755 ENOG4105C22 threonyL-tRNA synthetase HLB41_04760 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HLB41_04780 ENOG4105CN9 Peptidase m42 family protein HLB41_04785 ENOG4108JGH Tetr family transcriptional regulator HLB41_04790 ENOG4105CW7 secretion protein, HlyD family HLB41_04795 ENOG4105C0R drug resistance transporter emrb qaca subfamily HLB41_04820 ENOG4108RWN rrna methyltransferase HLB41_04830 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HLB41_04835 ENOG4105C5S asparaginyl-tRNA synthetase HLB41_04850 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HLB41_04865 ENOG4105DCG PHP domain protein HLB41_04875 ENOG4105FE9 pseudouridine synthase HLB41_04885 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) HLB41_04895 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) HLB41_04910 ENOG4105E0A ABC, transporter HLB41_04915 ENOG4105KFN sortase, SrtB family HLB41_04925 ENOG4105DR4 Methyltransferase HLB41_04940 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HLB41_04985 ENOG4105S6R Iron-hydroxamate transporter permease subunit HLB41_04990 ENOG4105J76 Periplasmic binding protein HLB41_05000 ENOG4105CEY Amp-dependent synthetase and ligase HLB41_05005 ENOG4107Z3H Transcriptional regulator, TetR family HLB41_05010 ENOG41060WC Enoyl-CoA hydratase HLB41_05015 ENOG4105BZJ Electron transfer flavoprotein HLB41_05020 ENOG4105C10 Electron transfer flavoprotein HLB41_05025 ENOG4105K63 Thioredoxin HLB41_05030 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HLB41_05040 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit HLB41_05050 ENOG4105E33 succinate dehydrogenase HLB41_05060 ENOG4108VXD carboxy-peptidase HLB41_05065 ENOG4105E14 MotA TolQ exbB proton channel HLB41_05070 ENOG4105ER2 Ompa motb domain protein HLB41_05075 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family HLB41_05080 ENOG4108IUX (ABC) transporter HLB41_05085 ENOG4105RHA ABC transporter, permease HLB41_05090 ENOG4108Z40 Transcriptional regulator HLB41_05095 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HLB41_05105 ENOG4108JCI Transcriptional regulator HLB41_05110 ENOG41067S9 phage shock protein C, PspC HLB41_05115 ENOG4105DZC cytosine deaminase HLB41_05125 ENOG4105PFC Transcriptional regulator HLB41_05150 ENOG4105CUZ uba thif-type nad fad binding protein HLB41_05220 ENOG4107ZQN disulfide bond HLB41_05225 ENOG4108KF3 Electron transport protein SCO1 SenC HLB41_05265 ENOG4105PFC Transcriptional regulator HLB41_05275 ENOG4105KBX Transcriptional regulator, TetR family HLB41_05285 ENOG4108PCX Major Facilitator HLB41_05295 ENOG4108XJQ germination protein HLB41_05305 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HLB41_05310 ENOG4105M59 Phosphodiesterase, mj0936 family HLB41_05330 ENOG4108QCI YvbH-like oligomerisation region HLB41_05355 ENOG4108IUQ atp-dependent protease HLB41_05375 ENOG4105K56 Transcriptional regulator HLB41_05400 ENOG4105D52 delta-aminolevulinic acid dehydratase HLB41_05410 ENOG41068KH stage VI sporulation protein D HLB41_05420 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HLB41_05425 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HLB41_05435 ENOG4108Z03 MAF-like protein HLB41_05445 ENOG4105DFF Rod shape-determining protein mreb HLB41_05465 ENOG4107QMS site-determining protein HLB41_05480 ENOG4105C03 ribonuclease HLB41_05490 ENOG4105X36 (ribosomal) protein HLB41_05505 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HLB41_05515 ENOG4105EWM Histidine kinase HLB41_05520 ENOG4105C19 ABC transporter HLB41_05535 ENOG4105CQC Prephenate dehydratase HLB41_05540 ENOG4108RPX mosc domain containing protein HLB41_05555 ENOG4108IYU L-aspartate oxidase HLB41_05560 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HLB41_05565 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HLB41_05590 ENOG4108HUF Transporter HLB41_05605 ENOG41061AI Protein of unknown function (DUF2905) HLB41_05620 ENOG4105VIE preprotein translocase, subunit YajC HLB41_05630 ENOG4108QG2 Membrane HLB41_05635 ENOG4105CKP Polysaccharide Biosynthesis Protein HLB41_05645 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HLB41_05650 ENOG41076HS cation diffusion facilitator family transporter HLB41_05655 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HLB41_05665 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HLB41_05670 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HLB41_05680 ENOG4105CUT histidyl-tRNA synthetase HLB41_05690 ENOG4105CUZ uba thif-type nad fad binding protein HLB41_05695 ENOG4108VCI transcription factor, rsfa family HLB41_05700 ENOG4105D1H recombination factor protein RarA HLB41_05710 ENOG4105C3J Cysteine desulfurase HLB41_05715 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HLB41_05725 ENOG4105C7H Helicase, RecD TraA family HLB41_05730 ENOG41060CR HLB41_05745 ENOG4105C02 permease HLB41_05755 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HLB41_05775 ENOG4105HHA aminodeoxychorismate lyase HLB41_05785 ENOG4105XYU peptidase (U32 family) HLB41_05790 ENOG4105CFP Peptidase U32 HLB41_05800 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HLB41_05810 ENOG4107XRG penicillin-binding protein HLB41_05840 ENOG4105C28 cystathionine HLB41_05845 ENOG4105C0A alcohol dehydrogenase HLB41_05855 ENOG4108V5C ABC transporter HLB41_05860 ENOG4105S6R Iron-hydroxamate transporter permease subunit HLB41_05900 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HLB41_05910 ENOG4105MIR Phenylalanine 4-monooxygenase HLB41_05915 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HLB41_05950 ENOG4108MUZ hydrolase HLB41_05955 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HLB41_05960 ENOG4105G6Z alkaline phosphatase HLB41_05975 ENOG4108TVJ Nitroreductase HLB41_05995 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HLB41_06010 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase HLB41_06015 ENOG4105CQW ribosome biogenesis GTPase YqeH HLB41_06025 ENOG410812S Rna-binding protein HLB41_06035 ENOG4108WF2 Metal Dependent Phosphohydrolase HLB41_06045 ENOG4105DXX methyltransferase HLB41_06055 ENOG4105KQC Competence protein HLB41_06060 ENOG4108UK2 deaminase HLB41_06065 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HLB41_06075 ENOG4105TQK DNA polymerase iii, delta' subunit HLB41_06100 ENOG4105KVH Transcriptional regulator HLB41_06105 ENOG4105CSA Coproporphyrinogen iii oxidase HLB41_06135 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HLB41_06140 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HLB41_06150 ENOG4105KTH gatB Yqey HLB41_06155 ENOG41068P3 sporulation protein YqfC HLB41_06165 ENOG4105C9A Phoh family HLB41_06170 ENOG4105CTJ Metal Dependent Phosphohydrolase HLB41_06175 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HLB41_06180 ENOG4107YR5 Diacylglycerol kinase HLB41_06185 ENOG4105KG3 cytidine deaminase HLB41_06190 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HLB41_06215 ENOG4107XJU UPF0178 protein HLB41_06220 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HLB41_06225 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HLB41_06240 ENOG4105EGD dinuclear metal center protein, YbgI family HLB41_06265 ENOG41069ZM Protein of unknown function (DUF2624) HLB41_06270 ENOG4108JYZ YitT family HLB41_06275 ENOG4105FDK ABC transporter HLB41_06285 ENOG4105N80 Ferric uptake regulator, Fur family HLB41_06310 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HLB41_06320 ENOG4107RF6 penicillin-binding protein HLB41_06325 ENOG4105EXS phosphate abc transporter HLB41_06330 ENOG4105C8U phosphate abc transporter HLB41_06335 ENOG4105C8U phosphate abc transporter HLB41_06340 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HLB41_06345 ENOG4108UTW Plays a role in the regulation of phosphate uptake HLB41_06360 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HLB41_06370 ENOG4105DKQ ROK family HLB41_06380 ENOG4105C5X domain protein HLB41_06400 ENOG4105C28 cystathionine HLB41_06405 ENOG4105C28 cystathionine HLB41_06415 ENOG4105C3R Methionine synthase HLB41_06420 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HLB41_06455 ENOG4107R6U sodium dicarboxylate symporter HLB41_06525 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HLB41_06555 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HLB41_06585 ENOG4105D03 DNA-3-methyladenine glycosylase II HLB41_06630 ENOG4105C0D helicase HLB41_06660 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HLB41_06665 ENOG4105CJ1 ABC, transporter HLB41_06700 ENOG41080TC multidrug resistance protein HLB41_06725 ENOG4105WZW rhodanese family HLB41_06730 ENOG41082GG biotin lipoate A B protein ligase HLB41_06760 ENOG4107YBY Hydrolase HLB41_06770 ENOG4105CBJ Metal-dependent enzyme HLB41_06785 ENOG4105DC7 peptidase M24 HLB41_06810 ENOG4105CD2 stage iii sporulation protein aa HLB41_06815 ENOG4105KR5 Stage iii sporulation protein HLB41_06820 ENOG4108CQH stage III sporulation protein AC HLB41_06825 ENOG4105KQ4 Stage iii sporulation protein ad HLB41_06835 ENOG410644B Stage III sporulation protein af HLB41_06860 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HLB41_06865 ENOG4108ZSR alkaline shock protein HLB41_06875 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HLB41_06890 ENOG4105CTB Polyprenyl synthetase HLB41_06900 ENOG4105DX0 Hemolysin A HLB41_06905 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HLB41_06910 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HLB41_06915 ENOG4105S1Z Stage IV sporulation protein B HLB41_06920 ENOG4107QQR Sporulation HLB41_06935 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HLB41_06945 ENOG4108JUB Transcriptional regulator HLB41_06955 ENOG4107RDP Dehydrogenase HLB41_06960 ENOG4105CKM Branched-chain carboxylic acid kinase HLB41_06975 ENOG4105CPP Dehydrogenase, E1 component HLB41_06980 ENOG4105C7S Dehydrogenase HLB41_06990 ENOG4108QY0 Membrane HLB41_07000 ENOG4105G7B Protein of unknown function (DUF2992) HLB41_07010 ENOG4108HW3 (ABC) transporter HLB41_07015 ENOG4105E5Q amino acid AbC transporter HLB41_07020 ENOG4105CDA abc transporter atp-binding protein HLB41_07025 ENOG4108QEG Membrane HLB41_07030 ENOG4108VZI ErfK ybiS ycfS ynhG family protein HLB41_07045 ENOG4105D9U N-acetyltransferase HLB41_07050 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HLB41_07080 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HLB41_07095 ENOG4105EJQ L-serine dehydratase HLB41_07100 ENOG4105II7 pyrroline-5-carboxylate reductase HLB41_07105 ENOG41069FQ Metallo-beta-lactamase superfamily HLB41_07110 ENOG4108IXY short-chain dehydrogenase reductase HLB41_07125 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HLB41_07140 ENOG4105DBV ornithine carbamoyltransferase HLB41_07165 ENOG4105CGH 5'-nucleotidase HLB41_07170 ENOG4105DFD Na H antiporter HLB41_07180 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HLB41_07185 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HLB41_07195 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HLB41_07200 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HLB41_07225 ENOG4108R6K riboflavin synthase, subunit alpha HLB41_07230 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HLB41_07250 ENOG4108YM7 Gcn5-related n-acetyltransferase HLB41_07255 ENOG4105ETE Transcriptional regulator (LacI family HLB41_07265 ENOG4107SKW Inherit from COG: Alpha beta hydrolase HLB41_07285 ENOG4105RHY Pfam:UPF0157 HLB41_07295 ENOG4105CPC Aldo Keto reductase HLB41_07315 ENOG4105MZ9 stage II sporulation protein m HLB41_07320 ENOG4105I3K Ferric uptake regulator, Fur family HLB41_07330 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HLB41_07355 ENOG4105D7N magnesium and cobalt transport protein CorA HLB41_07390 ENOG4105DVE abc transporter atp-binding protein HLB41_07395 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HLB41_07400 ENOG4105DZ1 carboxypeptidase HLB41_07405 ENOG41082AN stage II sporulation protein HLB41_07415 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HLB41_07420 ENOG4105C8J )-transporter HLB41_07440 ENOG41090VF Stage v sporulation protein ac HLB41_07445 ENOG4105CZ3 stage V sporulation protein ad HLB41_07455 ENOG4105G6R Stage v sporulation protein ae HLB41_07465 ENOG4105DQF Hydrolase HLB41_07470 ENOG4105PTM secreted protein HLB41_07475 ENOG4107ZE5 PPIases accelerate the folding of proteins HLB41_07510 ENOG4105CE4 GlcNAc 6-P deacetylase HLB41_07530 ENOG4105CID antiterminator HLB41_07545 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HLB41_07565 ENOG4105BZU Histidine kinase HLB41_07575 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HLB41_07590 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HLB41_07605 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate HLB41_07615 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HLB41_07620 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) HLB41_07635 ENOG4105DTD Dehydrogenase HLB41_07640 ENOG4105K7K Transcriptional regulator HLB41_07675 ENOG4105CHU acetyl-coa acetyltransferase HLB41_07720 ENOG4105CG3 alpha amylase, catalytic region HLB41_07730 ENOG4107FKK extracellular solute-binding protein family 1 HLB41_07740 ENOG4105EG2 ABC transporter, permease HLB41_07745 ENOG4105FKQ transcriptional regulator HLB41_07750 ENOG4105CHM Aminotransferase HLB41_07760 ENOG4108HGU Histidine kinase HLB41_07780 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HLB41_07815 ENOG4105UIN HLB41_07825 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HLB41_07840 ENOG4105K6S Short-chain dehydrogenase reductase Sdr HLB41_07845 ENOG4105EPM Diguanylate phosphodiesterase HLB41_07860 ENOG4107IN1 Protein of unknown function (DUF1797) HLB41_07870 ENOG4108XRC Protein of unknown function (DUF458) HLB41_07905 ENOG4107ZYR domain protein HLB41_07910 ENOG4105CN5 Metallo-Beta-Lactamase HLB41_07920 ENOG4108X4Q Hydrolase HLB41_07925 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HLB41_07940 ENOG4105CPP Dehydrogenase, E1 component HLB41_07990 ENOG4105CXN decarboxylase HLB41_08010 ENOG4105ECY inositol monophosphatase HLB41_08020 ENOG4105CI3 gtp-binding protein typa HLB41_08025 ENOG4105QA2 HLB41_08045 ENOG4108IAB Phoh family HLB41_08060 ENOG4105CNI cell division protein FtsW HLB41_08065 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HLB41_08070 ENOG4107VFP cytochrome oxidase assembly HLB41_08110 ENOG4105EKQ RNA-directed DNA polymerase HLB41_08125 ENOG4106UY4 Inherit from COG: Scp-like extracellular HLB41_08140 ENOG4107TB6 phosphoglycerate mutase HLB41_08160 ENOG4106H78 methyltransferase HLB41_08170 ENOG4105H20 Sporulation integral membrane protein YlbJ HLB41_08175 ENOG4105D78 K07001 NTE family protein HLB41_08180 ENOG41063PX domain protein HLB41_08190 ENOG4105KNH Nucleic acid-binding protein HLB41_08215 ENOG41074B2 UPF0747 protein HLB41_08230 ENOG4105CJN penicillin-binding protein HLB41_08235 ENOG4105CJN penicillin-binding protein HLB41_08240 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HLB41_08250 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HLB41_08255 ENOG4105CNI cell division protein FtsW HLB41_08260 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HLB41_08265 ENOG4105D4A Cell wall formation (By similarity) HLB41_08275 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HLB41_08280 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HLB41_08290 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HLB41_08300 ENOG4105WR5 sporulation protein, YlmC YmxH family HLB41_08305 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HLB41_08310 ENOG4105DFA alanine racemase domain protein HLB41_08315 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HLB41_08320 ENOG41067XK integral membrane protein HLB41_08325 ENOG4105DBK s4 domain protein HLB41_08350 ENOG4105C34 Pseudouridine synthase HLB41_08370 ENOG4105CD3 dihydroorotase HLB41_08380 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HLB41_08385 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) HLB41_08400 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HLB41_08425 ENOG4105DC7 peptidase M24 HLB41_08440 ENOG4105DSJ YicC domain protein HLB41_08460 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HLB41_08465 ENOG4105C25 Primosomal protein n' HLB41_08480 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HLB41_08485 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HLB41_08490 ENOG4108ZF3 Phosphatase HLB41_08495 ENOG4105D9P serine threonine protein kinase HLB41_08500 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HLB41_08505 ENOG4105DJV ribulose-phosphate 3-epimerase HLB41_08510 ENOG4105FJ0 thiamine HLB41_08525 ENOG4108ZAA Alkaline-shock protein HLB41_08530 ENOG4105DP4 dak2 domain fusion protein ylov HLB41_08535 ENOG4105CB5 ATP-dependent DNA helicase recG HLB41_08550 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HLB41_08555 ENOG4105CHR reductase HLB41_08570 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HLB41_08575 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HLB41_08595 ENOG4105VB6 UPF0109 protein HLB41_08620 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) HLB41_08635 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HLB41_08640 ENOG4105C79 DNA protecting protein DprA HLB41_08645 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HLB41_08655 ENOG4108HE4 integrase family HLB41_08685 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HLB41_08695 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HLB41_08700 ENOG4105KNE Phosphatidate cytidylyltransferase HLB41_08705 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HLB41_08710 ENOG4105DZP Membrane-associated zinc metalloprotease HLB41_08720 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HLB41_08730 ENOG4105CHV Transcription elongation factor NusA HLB41_08735 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination HLB41_08740 ENOG4105VHM ribosomal protein HLB41_08750 ENOG4105W7A Protein of unknown function (DUF503) HLB41_08765 ENOG4105DTN riboflavin biosynthesis protein ribF HLB41_08785 ENOG4105C1V Peptidase, M16 HLB41_08795 ENOG4105E35 Dipicolinate synthase subunit A HLB41_08800 ENOG4108S0H Dipicolinic acid synthetase, b subunit HLB41_08805 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HLB41_08815 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HLB41_08825 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit HLB41_08835 ENOG4105CNU cell division protein FtsK HLB41_08845 ENOG4105FDP GntR family transcriptional regulator HLB41_08850 ENOG4105DIH basic membrane HLB41_08855 ENOG4108JQ9 ABC transporter HLB41_08860 ENOG4105UIB (ABC) transporter HLB41_08880 ENOG4108RKS Short-chain dehydrogenase reductase Sdr HLB41_08885 ENOG4105XZV Protein of unknown function (DUF3243) HLB41_08900 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HLB41_08905 ENOG4105CEV competence damage-inducible protein HLB41_08920 ENOG4105D48 metallophosphoesterase HLB41_08925 ENOG4105MCT stage V sporulation protein S HLB41_08930 ENOG4108IGT Dipeptidase HLB41_08935 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HLB41_08940 ENOG4105DQU oxidoreductase, subunit beta HLB41_08945 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HLB41_08975 ENOG410890F Dynamin family HLB41_08980 ENOG4105E0M Sulfatase HLB41_08990 ENOG4105F0V Cell wall hydrolase HLB41_09005 ENOG4105CS2 ec 3.2.1.21 HLB41_09010 ENOG4108S3Y transcriptional regulator HLB41_09030 ENOG41067MG lrgb family HLB41_09070 ENOG4105BZU Histidine kinase HLB41_09090 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HLB41_09095 ENOG4105D03 DNA-3-methyladenine glycosylase II HLB41_09100 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HLB41_09110 ENOG4105CGK Exodeoxyribonuclease III HLB41_09130 ENOG4105E0A ABC, transporter HLB41_09135 ENOG4105NIV Esterase HLB41_09145 ENOG4105VPX protein, conserved in bacteria HLB41_09150 ENOG410681U heavy metal transport detoxification protein HLB41_09155 ENOG4105C59 p-type ATPase HLB41_09165 ENOG4105K70 DNA-binding protein HLB41_09170 ENOG4105TMB Formate nitrite transporter HLB41_09185 ENOG4105C85 amino acid HLB41_09195 ENOG4108SJC Membrane HLB41_09200 ENOG4107QW4 alcohol dehydrogenase HLB41_09205 ENOG4105E98 transcriptional regulator DeoR family HLB41_09210 ENOG4105DE4 1-phosphofructokinase HLB41_09215 ENOG4105DM4 PTS System HLB41_09220 ENOG41069ER domain protein HLB41_09250 ENOG4106F1P AAA ATPase, central domain protein HLB41_09260 ENOG4105EN6 Membrane HLB41_09265 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HLB41_09270 ENOG4105CXI aluminum resistance protein HLB41_09275 ENOG4105KV4 Transcriptional regulator HLB41_09280 ENOG4105C5F glutamine synthetase HLB41_09320 ENOG41065S2 pneumococcal vaccine antigen HLB41_09325 ENOG4105DR5 peptidase HLB41_09330 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HLB41_09340 ENOG4105K7K Transcriptional regulator HLB41_09360 ENOG4108SVB resolvase HLB41_09370 ENOG4105CGH 5'-nucleotidase HLB41_09375 ENOG4108HW3 (ABC) transporter HLB41_09410 ENOG4105BZ1 (ABC) transporter HLB41_09415 ENOG4105BZ1 (ABC) transporter HLB41_09455 ENOG41067MG lrgb family HLB41_09465 ENOG4107RSM transcriptional regulator HLB41_09480 ENOG4105CJ1 ABC, transporter HLB41_09500 ENOG4107QIV Cytochrome c biogenesis protein HLB41_09555 ENOG4108903 Formimidoylglutamase HLB41_09560 ENOG4108VJ1 Transcriptional regulator (CarD family HLB41_09565 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HLB41_09570 ENOG4105CBC glutamate synthase HLB41_09580 ENOG4105CK7 Sodium proline symporter HLB41_09585 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HLB41_09590 ENOG4105FBA Phospholipase Carboxylesterase HLB41_09595 ENOG4105BZU Histidine kinase HLB41_09605 ENOG4107AYK membrAne HLB41_09640 ENOG4108IMY Transcriptional regulator HLB41_09645 ENOG4105CEY Amp-dependent synthetase and ligase HLB41_09650 ENOG4107ZYJ bioY protein HLB41_09655 ENOG4107F3J Amp-dependent synthetase and ligase HLB41_09675 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HLB41_09685 ENOG4105E5W Transporter HLB41_09715 ENOG4108I0Z Aconitate hydratase HLB41_09720 ENOG4105BZ1 (ABC) transporter HLB41_09735 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HLB41_09740 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HLB41_09765 ENOG4105W8X HesB YadR YfhF-family protein HLB41_09775 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HLB41_09785 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLB41_09790 ENOG4105C0H protease HLB41_09795 ENOG4105K4P CoA-binding domain protein HLB41_09800 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HLB41_09810 ENOG4105D9R oxidoreductase HLB41_09815 ENOG4108FPN Integrase HLB41_09820 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HLB41_09825 ENOG4105ZX1 Transposase C HLB41_09845 ENOG4105CIG ABC transporter HLB41_09855 ENOG4105EMN RNA polymerase sigma factor HLB41_09865 ENOG4108KGH TRANSCRIPTIONal HLB41_09870 ENOG4107QJT sodium dicarboxylate symporter HLB41_09925 ENOG4105CUB amino acid HLB41_09945 ENOG4108JB9 formate dehydrogenase HLB41_09955 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) HLB41_09960 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HLB41_09970 ENOG4105TMB Formate nitrite transporter HLB41_09975 ENOG4105D06 uba thif-type nad fad binding protein HLB41_09980 ENOG4105CVM Molybdenum cofactor synthesis domain protein HLB41_09985 ENOG4108ZAF Molybdopterin HLB41_09995 ENOG4105D1F ATP-binding protein HLB41_10010 ENOG410696E Membrane HLB41_10015 ENOG4105FR1 rard protein HLB41_10025 ENOG4105EWU Squalene--hopene cyclase HLB41_10035 ENOG4105CHR reductase HLB41_10040 ENOG4105C26 Dehydrogenase HLB41_10050 ENOG4108IA2 Sodium pantothenate symporter HLB41_10065 ENOG4106IQC argininosuccinate lyase HLB41_10075 ENOG410904N short-chain dehydrogenase reductase HLB41_10095 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HLB41_10115 ENOG4105VEQ Cold shock protein HLB41_10130 ENOG4108R1P HLB41_10140 ENOG41073R8 VanW family HLB41_10145 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HLB41_10155 ENOG4105KT7 mgtC SapB transporter HLB41_10195 ENOG4105CQB FAD linked oxidase domain protein HLB41_10230 ENOG4105CNG UPF0061 protein HLB41_10235 ENOG4105CIS alcohol dehydrogenase HLB41_10240 ENOG41082BM Transcriptional regulator, arsr family HLB41_10255 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HLB41_10280 ENOG4108A04 Beta-lactamase HLB41_10295 ENOG4105FFC UPF0187 protein HLB41_10320 ENOG4105DPN Oligoendopeptidase f HLB41_10325 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HLB41_10330 ENOG4105E5K Alpha-amylase HLB41_10360 ENOG4107V2S Transcriptional regulator HLB41_10370 ENOG4107CUJ Protein of unknown function (DUF2690) HLB41_10390 ENOG4105NX3 Membrane HLB41_10395 ENOG4105DQ5 transport system permease protein HLB41_10400 ENOG4105EHG Permease protein HLB41_10405 ENOG4108MES Periplasmic binding protein HLB41_10420 ENOG4107R3E Citrate transporter HLB41_10430 ENOG4108TN2 lmbE family HLB41_10490 ENOG4105H3G oxidoreductase HLB41_10515 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) HLB41_10605 ENOG4108ZJ4 polysaccharide deacetylase HLB41_10620 ENOG4105KVH Transcriptional regulator HLB41_10625 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HLB41_10635 ENOG4105JAB phenazine biosynthesis protein, phzf family HLB41_10675 ENOG4105KVH Transcriptional regulator HLB41_10680 ENOG4105KVH Transcriptional regulator HLB41_10685 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HLB41_10690 ENOG4105D9R oxidoreductase HLB41_10695 ENOG4108TZY GntR Family Transcriptional Regulator HLB41_10700 ENOG4105KVH Transcriptional regulator HLB41_10730 ENOG4105C44 Serine transporter HLB41_10745 ENOG41090KN UPF0303 protein HLB41_10755 ENOG4105F27 Major Facilitator HLB41_10760 ENOG4105CV8 reductase HLB41_10775 ENOG4105KVH Transcriptional regulator HLB41_10780 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HLB41_10785 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HLB41_10790 ENOG4108UX3 '-nucleotidase HLB41_10795 ENOG4105C8Q Methyl-accepting chemotaxis HLB41_10810 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HLB41_10820 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HLB41_10825 ENOG4105CIS alcohol dehydrogenase HLB41_10835 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HLB41_10840 ENOG4105CV1 Transketolase (EC 2.2.1.1) HLB41_10855 ENOG4105C6Z Gluconate HLB41_10860 ENOG4105CMG Carbohydrate kinase HLB41_10865 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HLB41_10870 ENOG4105XDF Protein of unknown function (DUF1272) HLB41_10875 ENOG4105DDN Pentapeptide repeat-containing protein HLB41_10895 ENOG4105C37 (CBS) domain HLB41_11030 ENOG4108PSK reductase HLB41_11060 ENOG4108RCM Nitroreductase HLB41_11065 ENOG4105KVH Transcriptional regulator HLB41_11080 ENOG4105CUT histidyl-tRNA synthetase HLB41_11085 ENOG4108Z66 YbaK ebsC protein HLB41_11105 ENOG4108K8S endonuclease I HLB41_11165 ENOG4105DYS nad(p)h dehydrogenase (quinone) HLB41_11175 ENOG4105CRW Short chain fatty acid transporter HLB41_11190 ENOG41069JR HLB41_11195 ENOG4105DA5 (ABC) transporter HLB41_11210 ENOG4105CZM Major Facilitator HLB41_11215 ENOG4107MII Sugar-specific transcriptional regulator TrmB HLB41_11230 ENOG4108ISG Major Facilitator HLB41_11240 ENOG4105PNM synthesis protein HLB41_11245 ENOG4108VXD carboxy-peptidase HLB41_11275 ENOG4106YAD MORN repeat variant HLB41_11505 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HLB41_11530 ENOG410874W AraC family transcriptional regulator HLB41_11535 ENOG41082W1 Cupin 2, conserved barrel domain protein HLB41_11550 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HLB41_11555 ENOG4108JQ1 Dehydrogenase HLB41_11575 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HLB41_11600 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) HLB41_11610 ENOG4105BZU Histidine kinase HLB41_11630 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) HLB41_11650 ENOG4105JQZ Methyltransferase HLB41_11665 ENOG4105K6H D-cysteine desulfhydrase HLB41_11685 ENOG4105C0R drug resistance transporter emrb qaca subfamily HLB41_11690 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HLB41_11735 ENOG41062D9 Histidine kinase HLB41_11740 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLB41_11860 ENOG4105D7V transposase HLB41_11875 ENOG4108YXU transcriptional regulator AsnC family HLB41_11880 ENOG4105CHR reductase HLB41_11885 ENOG4108IG5 Transcriptional regulator HLB41_11890 ENOG4107P5I polyketide synthase HLB41_11895 ENOG4105NAE bifunctional deaminase-reductase domain protein HLB41_11905 ENOG41085FC arsR family transcriptional regulator HLB41_11910 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase HLB41_11915 ENOG4105D6J arsenicaL-resistance protein HLB41_11925 ENOG4105ETE Transcriptional regulator (LacI family HLB41_11930 ENOG4105NWF RbsD or FucU transport HLB41_11940 ENOG4105CNN ABC, transporter HLB41_11950 ENOG4107W7X Aldolase HLB41_11955 ENOG4105DET Rhamnulokinase HLB41_11975 ENOG4105Z7P Acetyltransferase (GNAT) family HLB41_12000 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HLB41_12015 ENOG4105E1K spore germination protein HLB41_12030 ENOG4105GPN Uncharacterized conserved protein (DUF2294) HLB41_12035 ENOG4108TWJ NADH dehydrogenase subunit 5 HLB41_12060 ENOG4105CVP deoxyribo-dipyrimidine photolyase HLB41_12065 ENOG4108606 TspO/MBR family HLB41_12080 ENOG4105F6J Alpha beta hydrolase fold HLB41_12105 ENOG41090MY MarR family Transcriptional regulator HLB41_12130 ENOG4105CHJ isochorismatase hydrolase HLB41_12140 ENOG4105CGH 5'-nucleotidase HLB41_12155 ENOG4106A3M Cytochrome p-450 HLB41_12170 ENOG4105CSV Glutaminase HLB41_12190 ENOG4108Q8B Spore germination protein HLB41_12195 ENOG4108NHD germination protein HLB41_12205 ENOG4105CUB amino acid HLB41_12210 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HLB41_12215 ENOG4105YWU small acid-soluble spore protein HLB41_12225 ENOG41075H3 AraC family transcriptional regulator HLB41_12250 ENOG4105BZU Histidine kinase HLB41_12260 ENOG4108B31 Spore germination protein HLB41_12285 ENOG4108IMY Transcriptional regulator HLB41_12290 ENOG4105HDK L-asparaginase HLB41_12295 ENOG4108IJ0 Aspartate ammonia-lyase HLB41_12305 ENOG4105E2A Dehydrogenase HLB41_12330 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HLB41_12375 ENOG4105DWD nucleoside recognition domain protein HLB41_12390 ENOG4105FDT acyl-CoA dehydrogenase HLB41_12400 ENOG4108ZHR arsR family transcriptional regulator HLB41_12405 ENOG4106N3A copper homeostasis protein cutc HLB41_12415 ENOG4107258 Transcriptional regulator HLB41_12420 ENOG4105P4J Allophanate hydrolase, subunit 1 HLB41_12430 ENOG4105E7W lamb ycsf family protein HLB41_12445 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) HLB41_12450 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HLB41_12455 ENOG4107RF6 penicillin-binding protein HLB41_12490 ENOG4105F1N DNA alkylation repair HLB41_12500 ENOG4108IQI permease HLB41_12510 ENOG410635A Membrane HLB41_12560 ENOG4108PCN EamA-like transporter family HLB41_12575 ENOG4108XET gCN5-related N-acetyltransferase HLB41_12580 ENOG4108DMH HTH_ARAC HLB41_12605 ENOG4105C19 ABC transporter HLB41_12610 ENOG4105CMR udp-glucose 4-epimerase HLB41_12620 ENOG4105WEC Molybdate metabolism regulator HLB41_12625 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HLB41_12640 ENOG4105FS7 Transcriptional regulator HLB41_12645 ENOG4108TVJ Nitroreductase HLB41_12665 ENOG4108IBT Inherit from COG: transposase HLB41_12755 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HLB41_12800 ENOG4105C8Y Acetylornithine aminotransferase HLB41_12830 ENOG4105CKK Glycosyl transferase, family 2 HLB41_12840 ENOG4105CSH Transporter HLB41_12855 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HLB41_12885 ENOG41068WN HLB41_12905 ENOG4105VMP Transcriptional regulator HLB41_12915 ENOG4105G6Z alkaline phosphatase HLB41_12920 ENOG4107RBI VanW family HLB41_12930 ENOG4105ECK Fatty Acid Desaturase HLB41_12945 ENOG4107258 Transcriptional regulator HLB41_12955 ENOG4105II7 pyrroline-5-carboxylate reductase HLB41_12990 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) HLB41_13000 ENOG41061GT Aldolase HLB41_13010 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) HLB41_13015 ENOG4105DKT Transcriptional regulator HLB41_13025 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HLB41_13030 ENOG4105F5R ABC transporter HLB41_13035 ENOG4105D4B ABC, transporter HLB41_13050 ENOG4105MKU Transcriptional regulator HLB41_13065 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase HLB41_13075 ENOG41069ER domain protein HLB41_13095 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) HLB41_13115 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HLB41_13120 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HLB41_13125 ENOG4105CIH Imidazole acetol-phosphate transaminase HLB41_13145 ENOG41082JN Transcriptional regulator HLB41_13150 ENOG4105EYF MMPL domain protein HLB41_13155 ENOG4105C5H ABC transporter HLB41_13160 ENOG4105E0M Sulfatase HLB41_13165 ENOG4108ZCF integral membrane protein HLB41_13185 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase HLB41_13190 ENOG4107VC0 DNA alkylation repair enzyme HLB41_13225 ENOG4108AQF aminoglycoside N(3)-acetyltransferase HLB41_13260 ENOG4105D7T ABC transporter HLB41_13265 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein HLB41_13270 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HLB41_13275 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HLB41_13285 ENOG4105C02 permease HLB41_13340 ENOG4105CHM Aminotransferase HLB41_13375 ENOG41089UC methyltransferase, type 11 HLB41_13390 ENOG4107BMA Transglycosylase associated protein HLB41_13415 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HLB41_13475 ENOG4105EPR degv family HLB41_13480 ENOG4105DPN Oligoendopeptidase f HLB41_13495 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 HLB41_13520 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLB41_13525 ENOG4105BZU Histidine kinase HLB41_13530 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HLB41_13535 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) HLB41_13570 ENOG4107SET aldo keto reductase HLB41_13585 ENOG4105DTQ mandelate racemase muconate lactonizing HLB41_13605 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD HLB41_13615 ENOG4107T5V SNARE associated Golgi HLB41_13620 ENOG4105DCI Phosphohydrolase HLB41_13650 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein HLB41_13660 ENOG41080HI glycine oxidase HLB41_13665 ENOG4105CTU Proline racemase HLB41_13670 ENOG4105CTU Proline racemase HLB41_13675 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HLB41_13680 ENOG4105C26 Dehydrogenase HLB41_13685 ENOG4105BZG amino acid carrier protein HLB41_13705 ENOG4108M1A Chitin-binding protein HLB41_13755 ENOG4105C9U ATP-dependent DNA helicase RecQ HLB41_13770 ENOG4105EEM helicase HLB41_13790 ENOG4108Z7F N-acetyltransferase HLB41_13815 ENOG4105MSB protein, conserved in bacteria HLB41_13820 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HLB41_13850 ENOG4108M1A Chitin-binding protein HLB41_13855 ENOG41082BV acetyltransferase HLB41_13860 ENOG4105E66 phosphoriboisomerase A HLB41_13875 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HLB41_13885 ENOG4108IJ7 Glycine betaine HLB41_13890 ENOG4107SQ8 Glycine betaine HLB41_13920 ENOG4105E1F short-chain dehydrogenase reductase HLB41_13935 ENOG4107RUY (E1 component), alpha subunit HLB41_13945 ENOG4107QKR Dehydrogenase HLB41_13965 ENOG41062ES Transcriptional regulator HLB41_13980 ENOG4105E98 transcriptional regulator DeoR family HLB41_13995 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HLB41_14020 ENOG4107Z3H Transcriptional regulator, TetR family HLB41_14025 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) HLB41_14030 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) HLB41_14060 ENOG4105MSI germination protein ypeb HLB41_14105 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HLB41_14115 ENOG4105FDR Membrane HLB41_14120 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HLB41_14125 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) HLB41_14140 ENOG4105CGH 5'-nucleotidase HLB41_14150 ENOG4108IUM Glycogen debranching enzyme HLB41_14205 ENOG4107VFR oxidoreductase HLB41_14225 ENOG4105CJ1 ABC, transporter HLB41_14255 ENOG4105PKS Excinuclease abc c subunit domain protein HLB41_14265 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HLB41_14290 ENOG4105KWG Pfam:DUF1696 HLB41_14295 ENOG4108NRW Phospholipase, patatin family HLB41_14315 ENOG4108XI2 Domain of unknown function (DUF1963) HLB41_14320 ENOG4105KME endoribonuclease L-psp HLB41_14340 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HLB41_14345 ENOG4105E09 nadh pyrophosphatase HLB41_14360 ENOG4105FCD Major Facilitator HLB41_14405 ENOG4107Y9U Membrane HLB41_14430 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HLB41_14445 ENOG4107Y80 Major Facilitator superfamily HLB41_14495 ENOG4105CJN penicillin-binding protein HLB41_14500 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HLB41_14505 ENOG4105CB2 alcohol dehydrogenase HLB41_14570 ENOG4108HGU Histidine kinase HLB41_14585 ENOG4108JJB ABC transporter HLB41_14610 ENOG4107RF6 penicillin-binding protein HLB41_14615 ENOG4105BZU Histidine kinase HLB41_14620 ENOG410667J hydrolase HLB41_14645 ENOG4106A3M Cytochrome p-450 HLB41_14720 ENOG4105ETU transcriptional activator (TenA HLB41_14725 ENOG4105CPF Cell wall formation (By similarity) HLB41_14735 ENOG4105D6E homoserine dehydrogenase HLB41_14800 ENOG4105DK7 lysyl-tRNA synthetase HLB41_14810 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein HLB41_14820 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HLB41_14825 ENOG410900G Protein of unknown function (DUF421) HLB41_14835 ENOG4105CPQ Dehydrogenase HLB41_14910 ENOG4105KVH Transcriptional regulator HLB41_14915 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HLB41_14920 ENOG4107Y80 Major Facilitator superfamily HLB41_14930 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HLB41_14960 ENOG41075H3 AraC family transcriptional regulator HLB41_14980 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HLB41_14990 ENOG4105T9C HD domain HLB41_15005 ENOG4105DZ1 carboxypeptidase HLB41_15040 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HLB41_15045 ENOG4107QX3 carboxylase HLB41_15050 ENOG4105E39 Enoyl-CoA hydratase HLB41_15055 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HLB41_15060 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit HLB41_15065 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HLB41_15070 ENOG4105C1G acyl-Coa dehydrogenase HLB41_15085 ENOG4107Z3H Transcriptional regulator, TetR family HLB41_15095 ENOG4105CJ1 ABC, transporter HLB41_15105 ENOG4105DIN metallophosphoesterase HLB41_15115 ENOG4107RF6 penicillin-binding protein HLB41_15120 ENOG4107RF6 penicillin-binding protein HLB41_15135 ENOG4107RVG penicillin-binding protein HLB41_15140 ENOG4105FQP Beta-lactamase HLB41_15200 ENOG4105W8Z 4'-phosphopantetheinyl transferase HLB41_15240 ENOG4105EQK -acetyltransferase HLB41_15245 ENOG4105EJ9 Membrane HLB41_15255 ENOG4105KRN Transcriptional regulator, abrb family HLB41_15280 ENOG4105CIN aminoacyl-histidine dipeptidase HLB41_15305 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HLB41_15310 ENOG41090HR transcriptional regulator HLB41_15315 ENOG4107RA9 decarboxylase HLB41_15330 ENOG41088CC tellurite resistance protein tehB HLB41_15350 ENOG4108RZE Tetr family transcriptional regulator HLB41_15360 ENOG4105C1J atp-dependent rna helicase HLB41_15370 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HLB41_15390 ENOG4108INS Transcriptional regulator HLB41_15400 ENOG4107STF Involved in phosphonate degradation (By similarity) HLB41_15405 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HLB41_15410 ENOG4105RD7 BadF BadG BcrA BcrD HLB41_15415 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HLB41_15435 ENOG4105F32 YngK protein HLB41_15465 ENOG4108KPJ rna polymerase sigma factor HLB41_15470 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) HLB41_15500 ENOG4108JCI Transcriptional regulator HLB41_15525 ENOG4105BZ1 (ABC) transporter HLB41_15530 ENOG4105BZ1 (ABC) transporter HLB41_15545 ENOG4108RPX mosc domain containing protein HLB41_15550 ENOG4105DND Transcriptional regulator HLB41_15570 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HLB41_15575 ENOG4107V2S Transcriptional regulator HLB41_15605 ENOG41068WN HLB41_15615 ENOG4105C1Q protoporphyrinogen oxidase HLB41_15640 ENOG4105WCN acetyltransferase HLB41_15660 ENOG4105EYF MMPL domain protein HLB41_15670 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HLB41_15680 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) HLB41_15690 ENOG4108Y4K DNA-binding transcriptional activator HLB41_15700 ENOG41081I9 integral membrane protein HLB41_15715 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HLB41_15730 ENOG4105C19 ABC transporter HLB41_15735 ENOG4105C22 threonyL-tRNA synthetase HLB41_15740 ENOG4105FE9 pseudouridine synthase HLB41_15760 ENOG4105BZG amino acid carrier protein HLB41_15780 ENOG4105K70 DNA-binding protein HLB41_15795 ENOG4105C0R drug resistance transporter emrb qaca subfamily HLB41_15800 ENOG4105WQT MbtH domain protein HLB41_15805 ENOG4105CEY Amp-dependent synthetase and ligase HLB41_15810 ENOG4105WQI isochorismatase HLB41_15815 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HLB41_15820 ENOG4105E4F Isochorismate synthase HLB41_15825 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HLB41_15830 ENOG4105FCD Major Facilitator HLB41_15855 ENOG4105EYH Exonuclease HLB41_15860 ENOG4107RFY SbcCD D subunit HLB41_15875 ENOG4105E39 Enoyl-CoA hydratase HLB41_15880 ENOG4105N14 lysine exporter protein LysE YggA HLB41_15890 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HLB41_15895 ENOG4105C1G acyl-Coa dehydrogenase HLB41_15900 ENOG4105CR4 methylisocitrate lyase HLB41_15905 ENOG4105DXD 2-methylcitrate dehydratase HLB41_15915 ENOG4105W8X HesB YadR YfhF-family protein HLB41_15920 ENOG4105CZM Major Facilitator HLB41_15930 ENOG4105BZ4 penicillin-binding protein HLB41_15990 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HLB41_16035 ENOG4105KNA -acetyltransferase HLB41_16040 ENOG4105SZ6 Thioredoxin HLB41_16050 ENOG410841Q phosphoesterase PA-phosphatase related protein HLB41_16095 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HLB41_16100 ENOG4108JUB Transcriptional regulator HLB41_16105 ENOG4108TSC N-acetyltransferase HLB41_16110 ENOG4107S4Y M20 DapE family protein YgeY HLB41_16125 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HLB41_16150 ENOG4105C37 (CBS) domain HLB41_16185 ENOG4105E90 ABC transporter HLB41_16190 ENOG4108IJ8 ABC transporter HLB41_16215 ENOG4108YV3 Protein of unknown function (DUF2711) HLB41_16225 ENOG4105C6Z Gluconate HLB41_16230 ENOG4105CMG Carbohydrate kinase HLB41_16250 ENOG4107ZY0 Phenazine biosynthesis-like protein HLB41_16255 ENOG4106KNT transcriptional regulator HLB41_16260 ENOG4105WH1 Two component transcriptional regulator luxr family HLB41_16265 ENOG4105BZU Histidine kinase HLB41_16270 ENOG4105D8X mechanosensitive ion channel HLB41_16300 ENOG4105F0I Aminotransferase HLB41_16305 ENOG4108MES Periplasmic binding protein HLB41_16310 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HLB41_16325 ENOG4105CAQ asparagine synthetase HLB41_16330 ENOG4107Y70 Heat shock protein HLB41_16335 ENOG4108KF3 Electron transport protein SCO1 SenC HLB41_16345 ENOG4108RCR degv family HLB41_16355 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HLB41_16365 ENOG4108UT2 hemolysin iii HLB41_16370 ENOG4105E9Q Acyl-transferase HLB41_16375 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HLB41_16380 ENOG4107RVG penicillin-binding protein HLB41_16390 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HLB41_16395 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) HLB41_16410 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 HLB41_16435 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HLB41_16440 ENOG4105VMP Transcriptional regulator HLB41_16450 ENOG4105KD7 acetyltransferase HLB41_16470 ENOG4105CY2 Citrate transporter HLB41_16475 ENOG4107XGZ Hydrolase HLB41_16495 ENOG4105C8J )-transporter HLB41_16510 ENOG41062D9 Histidine kinase HLB41_16515 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLB41_16525 ENOG4105BZW Glycerate kinase HLB41_16530 ENOG4105C5S asparaginyl-tRNA synthetase HLB41_16545 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HLB41_16570 ENOG4105C75 arginyL-tRNA synthetase HLB41_16575 ENOG4107YX5 Pfam:DUF548 HLB41_16595 ENOG4108UUM single-stranded DNA-binding protein HLB41_16610 ENOG4105C5H ABC transporter HLB41_16655 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HLB41_16660 ENOG4108FPN Integrase HLB41_16685 ENOG4105MCT stage V sporulation protein S HLB41_16720 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) HLB41_16725 ENOG4108IFG nitrite reductase, (NAD(P)H) HLB41_16730 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit HLB41_16735 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HLB41_16740 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HLB41_16745 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein HLB41_16775 ENOG4108ZAF Molybdopterin HLB41_16780 ENOG4105CVM Molybdenum cofactor synthesis domain protein HLB41_16785 ENOG4105D06 uba thif-type nad fad binding protein HLB41_16790 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HLB41_16795 ENOG4107V6Q Cyclic nucleotide-binding domain HLB41_16805 ENOG4105R3A Nitrate reductase HLB41_16810 ENOG4108IUE nitrate reductase beta subunit HLB41_16820 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HLB41_16835 ENOG4108V06 Glutathione peroxidase HLB41_16845 ENOG4105CNW domain protein HLB41_16855 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HLB41_16865 ENOG4105EMN RNA polymerase sigma factor HLB41_16870 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HLB41_16880 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HLB41_16905 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HLB41_16930 ENOG4105KBJ sporulation protein ytfj HLB41_17055 ENOG4108MGT Required for secretion of EsxA and EsxB HLB41_17090 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HLB41_17120 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HLB41_17125 ENOG4108JYZ YitT family HLB41_17130 ENOG41087PP glycosyltransferase MGT family HLB41_17145 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HLB41_17160 ENOG4108X4Q Hydrolase HLB41_17170 ENOG4108ZRV stage ii sporulation protein p HLB41_17190 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HLB41_17200 ENOG4108VXD carboxy-peptidase HLB41_17210 ENOG4108ZRV stage ii sporulation protein p HLB41_17230 ENOG4108Z7R Chaperone CsaA HLB41_17250 ENOG4105C37 (CBS) domain HLB41_17255 ENOG4105SXS Protein of unknown function (DUF456) HLB41_17275 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HLB41_17285 ENOG4108S4H thioesterase Superfamily protein HLB41_17295 ENOG4108PJD permease HLB41_17310 ENOG4107T5V SNARE associated Golgi HLB41_17355 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HLB41_17365 ENOG4105K4T epimerase HLB41_17375 ENOG4105DSE periplasmic solute binding protein HLB41_17385 ENOG4105CKI cobalamin synthesis protein HLB41_17390 ENOG4107QM2 Aldo Keto reductase HLB41_17395 ENOG4105VMI -acetyltransferase HLB41_17410 ENOG4105DEN Luciferase family HLB41_17425 ENOG4108WPJ Ferritin-like domain HLB41_17430 ENOG4108K88 Membrane HLB41_17445 ENOG4105C8Q Methyl-accepting chemotaxis HLB41_17470 ENOG4105KAF membrAne HLB41_17480 ENOG4107XZQ multidrug resistance protein HLB41_17485 ENOG4105CPC Aldo Keto reductase HLB41_17490 ENOG4105YVS arsR family transcriptional regulator HLB41_17500 ENOG4105KRN Transcriptional regulator, abrb family HLB41_17550 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HLB41_17555 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HLB41_17565 ENOG4105YWU small acid-soluble spore protein HLB41_17570 ENOG4108WBH protein TIM barrel HLB41_17585 ENOG4105CEY Amp-dependent synthetase and ligase HLB41_17590 ENOG4105DUU IucA IucC family protein HLB41_17600 ENOG4105VRR gCN5-related N-acetyltransferase HLB41_17605 ENOG4105KT7 mgtC SapB transporter HLB41_17620 ENOG4105BZU Histidine kinase HLB41_17625 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HLB41_17635 ENOG4108KGH TRANSCRIPTIONal HLB41_17650 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HLB41_17660 ENOG4105D6E homoserine dehydrogenase HLB41_17685 ENOG41075D4 Aminoglycoside 6-adenylyltransferase HLB41_17700 ENOG4105BZU Histidine kinase HLB41_17705 ENOG4105EFI regulatoR HLB41_17710 ENOG4105BZ1 (ABC) transporter HLB41_17765 ENOG4108UT6 Transferase hexapeptide repeat containing protein HLB41_17775 ENOG4105K64 Glycosyl transferase, family 2 HLB41_17785 ENOG4108JJ8 (ABC) transporter HLB41_17790 ENOG4108JJ9 ABC, transporter HLB41_17795 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HLB41_17800 ENOG4105C4M (Ubiquinol oxidase) subunit I HLB41_17810 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HLB41_17830 ENOG4105SKE transcriptional Regulator LysR family HLB41_17840 ENOG4105C32 Amino acid ABC transporter (Permease) HLB41_17845 ENOG4108IV0 ABC, transporter HLB41_17850 ENOG4105C0Z ABC transporter HLB41_17860 ENOG4105CKI cobalamin synthesis protein HLB41_17870 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HLB41_17875 ENOG4106F5Q Membrane HLB41_17880 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HLB41_17885 ENOG4108TVJ Nitroreductase HLB41_17890 ENOG4107ZXU DSBA oxidoreductase HLB41_17895 ENOG4108Z40 Transcriptional regulator HLB41_17900 ENOG4105GZI Transcriptional regulator HLB41_17905 ENOG4107RT3 EamA-like transporter family HLB41_17910 ENOG4105KTB nuclear export factor GLE1 HLB41_17915 ENOG4108T5E Copper resistance protein HLB41_17955 ENOG4107R16 Multicopper oxidase HLB41_17965 ENOG4107RAQ aminopeptidase HLB41_17985 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HLB41_17990 ENOG4105D9N nucleoside HLB41_18000 ENOG4107RHR regulatoR HLB41_18015 ENOG4105K8R UPF0145 protein HLB41_18020 ENOG410849A acetyltransferase, (GNAT) family HLB41_18065 ENOG4105C0X amino acid HLB41_18070 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HLB41_18085 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HLB41_18105 ENOG41068WN HLB41_18150 ENOG4105CYC Transferase HLB41_18155 ENOG4105DY9 regulatoR HLB41_18165 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HLB41_18170 ENOG4105C6X Major Facilitator HLB41_18195 ENOG4105C7B Threonine dehydratase HLB41_18200 ENOG4105C01 Dihydroxy-acid dehydratase HLB41_18205 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HLB41_18215 ENOG4105C7K acetolactate synthase HLB41_18220 ENOG4105CM2 brancheD-chain amino acid aminotransferase HLB41_18225 ENOG4105CHR reductase HLB41_18230 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HLB41_18250 ENOG4105H67 Protein of unknown function (DUF421) HLB41_18255 ENOG4105X5K response regulator receiver protein HLB41_18265 ENOG4105C8J )-transporter HLB41_18285 ENOG4105C6T cysteine synthase HLB41_18290 ENOG4105EU0 Major facilitator Superfamily HLB41_18295 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HLB41_18310 ENOG4105DXI Major Facilitator superfamily HLB41_18320 ENOG4105U3E Transcriptional regulator HLB41_18325 ENOG4105CSR polyphosphate kinase 2 HLB41_18340 ENOG4105E09 nadh pyrophosphatase HLB41_18345 ENOG4105FVX HLB41_18395 ENOG4105C6K Malic enzyme HLB41_18400 ENOG4108IJ0 Aspartate ammonia-lyase HLB41_18415 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HLB41_18435 ENOG4105CJ1 ABC, transporter HLB41_18470 ENOG4106BRA Membrane HLB41_18475 ENOG4105BZC d-serine deaminase HLB41_18490 ENOG4107JM4 Tetratricopeptide repeat HLB41_18505 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HLB41_18510 ENOG4107QIV Cytochrome c biogenesis protein HLB41_18530 ENOG4105EC3 peptidase S51, dipeptidase E HLB41_18535 ENOG4107QJQ Mate efflux family protein HLB41_18550 ENOG4105C9Q fumarate hydratase class II HLB41_18560 ENOG4105VUF Transcriptional regulator HLB41_18565 ENOG4105DFD Na H antiporter HLB41_18580 ENOG4108PJD permease HLB41_18585 ENOG4105CKI cobalamin synthesis protein HLB41_18595 ENOG4108UZ3 Transporter HLB41_18600 ENOG4105DRR Transcriptional regulator, GntR family HLB41_18610 ENOG4105PGM cation diffusion facilitator family transporter HLB41_18630 ENOG4105CAQ asparagine synthetase HLB41_18650 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HLB41_18660 ENOG4105CVJ phosphoglycerate mutase HLB41_18695 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component HLB41_18700 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HLB41_18735 ENOG4105KAC Antibiotic biosynthesis monooxygenase HLB41_18770 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HLB41_18775 ENOG4105KTQ flagellar basal-body rod protein HLB41_18780 ENOG4105FZW flagellar biosynthesis regulator FlhF HLB41_18785 ENOG4105D7B Flagellar biosynthesis protein flha HLB41_18790 ENOG4105D00 flagellar biosynthetic protein flhB HLB41_18800 ENOG4105VS8 Flagellar biosynthetic protein fliq HLB41_18805 ENOG4105CN7 Flagellar biosynthetic protein FliP HLB41_18815 ENOG4105DD5 Flagellar motor switch protein HLB41_18820 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HLB41_18830 ENOG4105E4C Lytic transglycosylase catalytic HLB41_18835 ENOG4105I03 Flagellin HLB41_18840 ENOG4105I03 Flagellin HLB41_18850 ENOG4107R88 Chemotaxis protein (CheV) HLB41_18865 ENOG4105BZE flagellar hook protein, FlgE HLB41_18895 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HLB41_18900 ENOG4107U2N Flagellar M-ring protein HLB41_18910 ENOG4108ZC9 flagellar basal-body rod protein flgc HLB41_18915 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HLB41_18935 ENOG4105DTJ flagellar hook-associated protein HLB41_18940 ENOG4105E1Q flagellar hook-associated protein HLB41_18960 ENOG4105BZU Histidine kinase HLB41_18975 ENOG4105DD5 Flagellar motor switch protein HLB41_18980 ENOG4105CBS Chea signal transduction histidine kinase HLB41_18985 ENOG4107YTP response regulator receiver protein HLB41_18990 ENOG4105ER2 Ompa motb domain protein HLB41_18995 ENOG4107R0U MotA TolQ exbB proton channel HLB41_19005 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HLB41_19040 ENOG41080C8 DUF218 domain HLB41_19045 ENOG4105H67 Protein of unknown function (DUF421) HLB41_19055 ENOG4108Z5V transcriptional regulator, merr family HLB41_19060 ENOG4105CN5 Metallo-Beta-Lactamase HLB41_19065 ENOG4107RWR Sodium hydrogen exchanger HLB41_19075 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HLB41_19140 ENOG41081VK Ribonuclease HLB41_19160 ENOG4108SZE gCN5-related N-acetyltransferase HLB41_19175 ENOG4105CPK Glycosyl transferase (Group 1 HLB41_19205 ENOG4105HTX biosynthesis protein HLB41_19260 ENOG4105KHC sulfurtransferase HLB41_19270 ENOG4108W0I acetyltransferase HLB41_19280 ENOG410890F Dynamin family HLB41_19285 ENOG4105DHF Membrane HLB41_19290 ENOG4105C2W permease HLB41_19295 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) HLB41_19305 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HLB41_19315 ENOG4105CTD carboxy-peptidase HLB41_19320 ENOG4105DVT helicase HLB41_19330 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HLB41_19345 ENOG4106F55 Protein of unknown function (DUF1273) HLB41_19385 ENOG4105BZ4 penicillin-binding protein HLB41_19395 ENOG4105CSM endonuclease III HLB41_19415 ENOG4105YAC HLB41_19420 ENOG4105DVT helicase HLB41_19435 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HLB41_19455 ENOG4105CPK Glycosyl transferase (Group 1 HLB41_19460 ENOG4105FJR Lmbe family HLB41_19470 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HLB41_19475 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase HLB41_19480 ENOG4108JYZ YitT family HLB41_19515 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HLB41_19520 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) HLB41_19535 ENOG41068YB TPR repeat-containing protein HLB41_19545 ENOG4105D49 3-dehydroquinate synthase HLB41_19550 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HLB41_19555 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HLB41_19560 ENOG4105EAH synthase HLB41_19570 ENOG4105XXQ heptaprenyl diphosphate synthase component I HLB41_19585 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) HLB41_19615 ENOG41065D1 HLB41_19620 ENOG4105S2F HLB41_19635 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HLB41_19655 ENOG4107RB3 L-asparaginase HLB41_19660 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase HLB41_19685 ENOG4108S6Z Negative regulator of genetic competence HLB41_19690 ENOG4108XDN Transcriptional regulator HLB41_19695 ENOG4107RGJ metallophosphoesterase HLB41_19705 ENOG4105I7S Abortive infection protein HLB41_19710 ENOG4105C9U ATP-dependent DNA helicase RecQ HLB41_19725 ENOG4108SAX Membrane HLB41_19740 ENOG4108WBT adenosyltransferase HLB41_19745 ENOG4105BZU Histidine kinase HLB41_19750 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLB41_19755 ENOG4105CRE cytochrome C HLB41_19760 ENOG4107TWT Cytochrome c biogenesis protein HLB41_19765 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HLB41_19770 ENOG4105FE9 pseudouridine synthase HLB41_19780 ENOG4108JIC nucleoside recognition domain protein HLB41_19785 ENOG4105DZ1 carboxypeptidase HLB41_19790 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HLB41_19815 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HLB41_19820 ENOG4105BZU Histidine kinase HLB41_19835 ENOG4105I3N Conserved Protein HLB41_19840 ENOG4105BZU Histidine kinase HLB41_19855 ENOG4105BZ4 penicillin-binding protein HLB41_19860 ENOG4107GRR phosphate transport regulator HLB41_19865 ENOG4105CJ3 phosphate transporter HLB41_19885 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HLB41_19910 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HLB41_19930 ENOG4105WH1 Two component transcriptional regulator luxr family HLB41_19935 ENOG4105ENE Histidine kinase HLB41_19955 ENOG4105DFD Na H antiporter HLB41_19980 ENOG4105C8J )-transporter HLB41_19985 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein HLB41_19990 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HLB41_19995 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HLB41_20005 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HLB41_20010 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HLB41_20015 ENOG4107S4M Sulfate adenylate transferase HLB41_20030 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HLB41_20040 ENOG4105E0M Sulfatase HLB41_20045 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HLB41_20060 ENOG4107RVV histidinol phosphate phosphatase, hisj family HLB41_20065 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase HLB41_20075 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HLB41_20080 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HLB41_20085 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HLB41_20090 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HLB41_20095 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HLB41_20100 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HLB41_20115 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HLB41_20130 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HLB41_20135 ENOG4108ZP8 Acetolactate synthase small subunit HLB41_20140 ENOG4105C7K acetolactate synthase HLB41_20145 ENOG4105CM2 brancheD-chain amino acid aminotransferase HLB41_20165 ENOG4105KBJ sporulation protein ytfj HLB41_20170 ENOG41063Y9 HLB41_20175 ENOG4105CZN Potassium uptake protein HLB41_20205 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HLB41_20245 ENOG4105NQC Flavodoxin HLB41_20265 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HLB41_20275 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD HLB41_20280 ENOG4105EA8 2-Nitropropane dioxygenase HLB41_20285 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HLB41_20325 ENOG4105CJ1 ABC, transporter HLB41_20335 ENOG4105CZV ABC transporter HLB41_20340 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HLB41_20345 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HLB41_20350 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HLB41_20355 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HLB41_20390 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HLB41_20395 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HLB41_20400 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HLB41_20405 ENOG4105BZU Histidine kinase HLB41_20410 ENOG4106DF1 HLB41_20420 ENOG41090MY MarR family Transcriptional regulator HLB41_20425 ENOG4105BZU Histidine kinase HLB41_20435 ENOG4105PXI polysaccharide deacetylase HLB41_20445 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HLB41_20455 ENOG4105E98 transcriptional regulator DeoR family HLB41_20475 ENOG4107RCV ABC transporter, permease HLB41_20480 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HLB41_20485 ENOG4105C4Y ABC transporter HLB41_20515 ENOG4105CHR reductase HLB41_20535 ENOG4108Z7G MaoC domain protein dehydratase HLB41_20540 ENOG410681C small acid-soluble spore protein HLB41_20545 ENOG4105CZN Potassium uptake protein HLB41_20550 ENOG4107TS3 membrane protein, TerC HLB41_20555 ENOG4108QTI )-transporter HLB41_20565 ENOG4106A3R peptidase HLB41_20585 ENOG4105JXH GntR family transcriptional regulator HLB41_20590 ENOG4105BZU Histidine kinase HLB41_20595 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLB41_20610 ENOG4105CQB FAD linked oxidase domain protein HLB41_20615 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HLB41_20620 ENOG4105K4I Scp-like extracellular HLB41_20630 ENOG4108YBP pseudouridine synthase HLB41_20640 ENOG4105EYF MMPL domain protein HLB41_20650 ENOG4108HM4 ABC transporter HLB41_20655 ENOG4105D38 putrescine abc transporter HLB41_20660 ENOG4105F38 ABC transporter, permease HLB41_20665 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HLB41_20670 ENOG4105C26 Dehydrogenase HLB41_20705 ENOG4105VFR signal peptidase HLB41_20710 ENOG4105DZ1 carboxypeptidase HLB41_20740 ENOG4105RHA ABC transporter, permease HLB41_20745 ENOG4108IUX (ABC) transporter HLB41_20760 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HLB41_20810 ENOG4105VZ8 Transcriptional regulator HLB41_20820 ENOG4105C7S Dehydrogenase HLB41_20885 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HLB41_20890 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HLB41_20895 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase HLB41_20900 ENOG4105DK0 Indole-3-glycerol phosphate synthase HLB41_20905 ENOG4108I0Q anthranilate phosphoribosyltransferase HLB41_20910 ENOG4105DDQ anthranilate synthase HLB41_20920 ENOG4105CK7 Sodium proline symporter HLB41_20995 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HLB41_21005 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HLB41_21010 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HLB41_21030 ENOG4107TVC Glycosyl transferase, family 2 HLB41_21050 ENOG4105K64 Glycosyl transferase, family 2 HLB41_21070 ENOG4105EMS pseudouridine synthase HLB41_21075 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HLB41_21090 ENOG4105MIX Adenylate cyclase HLB41_21095 ENOG4108Z18 K06886 hemoglobin HLB41_21110 ENOG4105DPN Oligoendopeptidase f HLB41_21120 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HLB41_21130 ENOG4108ZCF integral membrane protein HLB41_21150 ENOG4105UQX Mate efflux family protein HLB41_21155 ENOG4108JQ7 (ABC) transporter HLB41_21165 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HLB41_21170 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HLB41_21185 ENOG4105C31 Tryptophanyl-tRNA synthetase HLB41_21200 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HLB41_21205 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HLB41_21230 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HLB41_21240 ENOG4108KP7 hydrolase HLB41_21250 ENOG41073B9 HLB41_21255 ENOG4107AYK membrAne HLB41_21265 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HLB41_21325 ENOG4105QNR S1 RNA binding domain protein HLB41_21345 ENOG4105BZU Histidine kinase HLB41_21350 ENOG4105CH6 catalase HLB41_21355 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HLB41_21360 ENOG4105CAQ asparagine synthetase HLB41_21375 ENOG4105C8Y Acetylornithine aminotransferase HLB41_21385 ENOG4105ERH Fumarylacetoacetate hydrolase HLB41_21430 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation HLB41_21490 ENOG4107QP3 malate synthase g HLB41_21500 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) HLB41_21505 ENOG4105C8Q Methyl-accepting chemotaxis HLB41_21510 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 HLB41_21530 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HLB41_21540 ENOG41086D8 Transcriptional regulator HLB41_21545 ENOG4108AEY RNA polymerase sigma factor HLB41_21555 ENOG4107TVP HD domain protein HLB41_21560 ENOG4107RN3 metallophosphoesterase HLB41_21565 ENOG4105ENX hydrolase HLB41_21720 ENOG4108IJ6 ABC transporter HLB41_21725 ENOG4105ECW sulfate abc transporter HLB41_21730 ENOG4108I5D sulfate abc transporter HLB41_21735 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HLB41_21745 ENOG4105CEY Amp-dependent synthetase and ligase HLB41_21755 ENOG4105DF9 Lipoate-protein, ligase HLB41_21760 ENOG4108RQ5 Beta-lactamase domain-containing protein HLB41_21765 ENOG4106AXD HLB41_21775 ENOG4108MK9 spermidine N(1)-acetyltransferase HLB41_21795 ENOG4105ECB domain protein HLB41_21810 ENOG4105NA0 Transcriptional regulator HLB41_21835 ENOG4105C1Q protoporphyrinogen oxidase HLB41_21840 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HLB41_21850 ENOG4105BZ4 penicillin-binding protein HLB41_21855 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation HLB41_21860 ENOG4105CKV Membrane HLB41_21865 ENOG410905X membrane-flanked domain protein HLB41_21900 ENOG4105CKV Membrane HLB41_21905 ENOG410905X membrane-flanked domain protein HLB41_21940 ENOG4105K59 histidine triad (HIT) protein HLB41_21965 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HLB41_21975 ENOG4105EEM helicase HLB41_21990 ENOG4105DU6 RNA polymerase HLB41_22010 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HLB41_22025 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HLB41_22030 ENOG41067QW Transcriptional regulator HLB41_22035 ENOG4105F0F Oxalate decarboxylase HLB41_22060 ENOG4108MUZ hydrolase HLB41_22090 ENOG4106D4I domain protein HLB41_22095 ENOG4107VRP DNA repair exonuclease HLB41_22115 ENOG4107QHE Choloylglycine hydrolase HLB41_22160 ENOG4105BZU Histidine kinase HLB41_22165 ENOG4105BZU Histidine kinase HLB41_22170 ENOG4108MJI response regulator HLB41_22180 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HLB41_22190 ENOG4105WN5 stage II sporulation protein HLB41_22250 ENOG4108WC5 Alpha Beta Hydrolase Fold protein HLB41_22285 ENOG41069ER domain protein HLB41_22325 ENOG4105CMT Dihydroxyacetone kinase HLB41_22335 ENOG4105CMT Dihydroxyacetone kinase HLB41_22350 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HLB41_22390 ENOG4105F6J Alpha beta hydrolase fold HLB41_22410 ENOG4105EKQ RNA-directed DNA polymerase HLB41_22415 ENOG4105D9U N-acetyltransferase HLB41_22430 ENOG4105C0R drug resistance transporter emrb qaca subfamily HLB41_22455 ENOG4105CDU Replicative dna helicase HLB41_22490 ENOG4105DZR Type I site-specific deoxyribonuclease HLB41_22505 ENOG4105M6F mutator MutT protein HLB41_22515 ENOG4108MRH transcriptional regulatory protein HLB41_22525 ENOG4105CSH Transporter HLB41_22710 ENOG4108IBT Inherit from COG: transposase HLB41_22785 ENOG4108JQ7 (ABC) transporter HLB41_22790 ENOG4105C3U ABC transporter HLB41_22795 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HLB41_22810 ENOG4105CIF Ornithine Cyclodeaminase HLB41_22815 ENOG4105CTU Proline racemase HLB41_22835 ENOG4105DER m42 family HLB41_22855 ENOG4105CGU Enoyl-CoA hydratase HLB41_22880 ENOG4105CHH sulfate transporter HLB41_22895 ENOG4105CEY Amp-dependent synthetase and ligase HLB41_22900 ENOG4105D4P Coproporphyrinogen iii oxidase HLB41_22905 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HLB41_22920 ENOG4108VX5 3-methyladenine DNA glycosylase HLB41_22925 ENOG4107FQX Alpha-acetolactate decarboxylase HLB41_22935 ENOG4105WH1 Two component transcriptional regulator luxr family HLB41_22940 ENOG4105BZU Histidine kinase HLB41_22950 ENOG4108UH6 UPF0754 membrane protein HLB41_22960 ENOG410839P HLB41_22975 ENOG4105CDA abc transporter atp-binding protein HLB41_22980 ENOG4105DRP amino acid AbC transporter HLB41_22990 ENOG4105BZ1 (ABC) transporter HLB41_22995 ENOG4105BZ1 (ABC) transporter HLB41_23000 ENOG4105C26 Dehydrogenase HLB41_23010 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HLB41_23015 ENOG4105D5Q Arginine ornithine antiporter HLB41_23025 ENOG4105CH6 catalase HLB41_23030 ENOG4107RKG DJ-1/PfpI family HLB41_23045 ENOG4105E5W Transporter HLB41_23050 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HLB41_23055 ENOG4105NF4 modulator of drug activity HLB41_23095 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HLB41_23100 ENOG4105CH7 arginosuccinase HLB41_23105 ENOG4108YXU transcriptional regulator AsnC family HLB41_23140 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HLB41_23145 ENOG4106KNT transcriptional regulator HLB41_23155 ENOG4107RWR Sodium hydrogen exchanger HLB41_23160 ENOG4105CUB amino acid HLB41_23195 ENOG4107T5V SNARE associated Golgi HLB41_23230 ENOG4105WEF catalase HLB41_23260 ENOG4105C19 ABC transporter HLB41_23265 ENOG4107RBB ABC transporter, permease HLB41_23270 ENOG41069ER domain protein HLB41_23290 ENOG4105VZJ PTS System HLB41_23295 ENOG4105VCP PTS System HLB41_23300 ENOG4105EMD TRANSCRIPTIONal HLB41_23325 ENOG4108KGH TRANSCRIPTIONal HLB41_23335 ENOG41087NI Sulfite exporter TauE/SafE HLB41_23340 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase HLB41_23345 ENOG41085GJ domain protein HLB41_23350 ENOG4105VFE sira family HLB41_23355 ENOG4105VFE sira family HLB41_23360 ENOG4107TPS domain protein HLB41_23365 ENOG4105VFE sira family HLB41_23370 ENOG4105XTG Pfam:DUF156 HLB41_23375 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase HLB41_23390 ENOG4105J4Q Transcriptional regulator HLB41_23400 ENOG4105ED1 spovr family HLB41_23405 ENOG4107Y03 Nitroreductase HLB41_23425 ENOG4108B31 Spore germination protein HLB41_23445 ENOG4105K63 Thioredoxin HLB41_23460 ENOG4105C5Y PTS System HLB41_23480 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HLB41_23490 ENOG4105C7N Xanthine uracil vitamin C permease HLB41_23500 ENOG4105C2J ABC transporter HLB41_23505 ENOG4105CNN ABC, transporter HLB41_23520 ENOG4105C19 ABC transporter HLB41_23545 ENOG4108INS Transcriptional regulator HLB41_23560 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HLB41_23595 ENOG4105DWF phosphomethylpyrimidine kinase HLB41_23600 ENOG4105D06 uba thif-type nad fad binding protein HLB41_23615 ENOG41080HI glycine oxidase HLB41_23620 ENOG4108VEU Thiamine monophosphate synthase HLB41_23630 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HLB41_23640 ENOG4105ETU transcriptional activator (TenA HLB41_23660 ENOG41080XQ Signal transduction protein with cbs domains HLB41_23790 ENOG4105E2Z phosphate ABC transporter (Permease HLB41_23795 ENOG4105C8U phosphate abc transporter HLB41_23800 ENOG4105CVA phosphate HLB41_23805 ENOG4105CE1 Ferrous iron transport protein b HLB41_23810 ENOG4105CE1 Ferrous iron transport protein b HLB41_23815 ENOG4105CE1 Ferrous iron transport protein b HLB41_23820 ENOG4108NHD germination protein HLB41_23835 ENOG4105E1V na solute symporter HLB41_23840 ENOG4106CAD Protein of unknown function (DUF3311) HLB41_23860 ENOG4105E2S oxidase) subunit II HLB41_23865 ENOG4105BZ9 Cytochrome C oxidase, subunit I HLB41_23890 ENOG4105MA6 gCN5-related N-acetyltransferase HLB41_23905 ENOG4105C7N Xanthine uracil vitamin C permease HLB41_23910 ENOG4105C85 amino acid HLB41_23930 ENOG4105DUX Transporter HLB41_23945 ENOG4107D63 HLB41_23950 ENOG4105VZ8 Transcriptional regulator HLB41_23955 ENOG41069ER domain protein HLB41_23960 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HLB41_23965 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HLB41_23995 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) HLB41_24025 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HLB41_24030 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HLB41_24035 ENOG4105CNN ABC, transporter HLB41_24040 ENOG4105C2J ABC transporter HLB41_24045 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HLB41_24050 ENOG4108RVA ribokinase HLB41_24055 ENOG4105ETE Transcriptional regulator (LacI family HLB41_24060 ENOG4105C0R drug resistance transporter emrb qaca subfamily HLB41_24065 ENOG41067TZ transcriptional regulator, MarR family HLB41_24070 ENOG4105CXY transporter HLB41_24080 ENOG41068KF Universal stress protein HLB41_24085 ENOG4105CHH sulfate transporter HLB41_24105 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLB41_24110 ENOG4105BZU Histidine kinase HLB41_24115 ENOG4105NAE bifunctional deaminase-reductase domain protein HLB41_24120 ENOG4105D29 Helix-turn-helix type 11 domain protein HLB41_24145 ENOG4108IQI permease HLB41_24150 ENOG4105DRP amino acid AbC transporter HLB41_24155 ENOG4105EAD ABC transporter HLB41_24160 ENOG4105CT1 (ABC) transporter HLB41_24165 ENOG4105CDA abc transporter atp-binding protein HLB41_24170 ENOG4105BZG amino acid carrier protein HLB41_24175 ENOG4105CRN Aminoglycoside phosphotransferase HLB41_24185 ENOG4105E1K spore germination protein HLB41_24200 ENOG4105CG3 alpha amylase, catalytic region HLB41_24205 ENOG4105C5Y PTS System HLB41_24210 ENOG4107414 GntR family transcriptional regulator HLB41_24215 ENOG4105D5Q Arginine ornithine antiporter HLB41_24220 ENOG4105BZU Histidine kinase HLB41_24230 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HLB41_24235 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HLB41_24240 ENOG4107T89 von Willebrand factor, type A HLB41_24250 ENOG4105EXW epimerase dehydratase HLB41_24255 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HLB41_24265 ENOG4105E0A ABC, transporter HLB41_24270 ENOG4108IHU transport system permease protein HLB41_24275 ENOG4105DQ5 transport system permease protein HLB41_24280 ENOG4108MES Periplasmic binding protein HLB41_24285 ENOG4105DUX Transporter HLB41_24300 ENOG4105DAA L-lactate HLB41_24305 ENOG4108IJ0 Aspartate ammonia-lyase HLB41_24310 ENOG4105C37 (CBS) domain HLB41_24315 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HLB41_24320 ENOG4105D9N nucleoside HLB41_24325 ENOG4108KGH TRANSCRIPTIONal HLB41_24330 ENOG41073R8 VanW family HLB41_24370 ENOG4105C59 p-type ATPase HLB41_24380 ENOG4105CUB amino acid HLB41_24400 ENOG4108JB9 formate dehydrogenase HLB41_24405 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HLB41_24415 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLB41_24420 ENOG4105BZU Histidine kinase HLB41_24430 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HLB41_24435 ENOG4108UZ3 Transporter HLB41_24445 ENOG4105C6K Malic enzyme HLB41_24455 ENOG4108MRH transcriptional regulatory protein HLB41_24480 ENOG4105US7 Histidine kinase HLB41_24485 ENOG4108STX response regulator HLB41_24490 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HLB41_24495 ENOG4105BZ7 extracellular solute-binding protein family 1 HLB41_24500 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HLB41_24505 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HLB41_24510 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HLB41_24515 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HLB41_24540 ENOG4105D4T Citrate transporter HLB41_24545 ENOG4108V9W transcriptional regulatory protein HLB41_24550 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HLB41_24560 ENOG4105DZ6 Band 7 protein HLB41_24575 ENOG4105C94 Transporter HLB41_24590 ENOG4106AKX UPF0229 protein HLB41_24595 ENOG4105CYN Serine protein kinase HLB41_24600 ENOG4105BZU Histidine kinase HLB41_24605 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HLB41_24615 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HLB41_24625 ENOG4108R9S DSBA oxidoreductase HLB41_24630 ENOG4108JQC penicillin-binding protein 1A HLB41_24750 ENOG4105G5W regulator Fur family HLB41_24755 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HLB41_24775 ENOG4108IUW ABC transporter HLB41_24785 ENOG4105CBC glutamate synthase HLB41_24790 ENOG4107NBY Membrane HLB41_24795 ENOG4105BZ1 (ABC) transporter HLB41_24815 ENOG4106BXE HLB41_24820 ENOG4105CEN a g-specific adenine glycosylase HLB41_24825 ENOG41067AE Membrane-bound metal-dependent hydrolase HLB41_24855 ENOG4105ECP epimerase HLB41_24860 ENOG4105CI2 imidazolone-5-propionate hydrolase HLB41_24875 ENOG4108QBV Monogalactosyldiacylglycerol synthase HLB41_24880 ENOG4105F1A Pyruvate formate-lyase HLB41_24900 ENOG4105C3I Nad-dependent epimerase dehydratase HLB41_24905 ENOG4107QQG Dehydrogenase HLB41_24910 ENOG4105CKK Glycosyl transferase, family 2 HLB41_24925 ENOG4108A04 Beta-lactamase HLB41_24965 ENOG4108IQI permease HLB41_24975 ENOG4108JUB Transcriptional regulator HLB41_24985 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HLB41_24990 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HLB41_25025 ENOG4105UPD Calcium Proton HLB41_25030 ENOG410606W general stress protein HLB41_25045 ENOG4107ZTW SNARE associated Golgi HLB41_25055 ENOG4105C3F Signal peptidase i HLB41_25065 ENOG4108IPJ Membrane HLB41_25070 ENOG4105C59 p-type ATPase HLB41_25075 ENOG4107U9T Pfam:Ribonuclease_BN HLB41_25085 ENOG4105KJF protein tyrosine phosphatase HLB41_25105 ENOG4108TTB tellurium resistance protein HLB41_25110 ENOG4107TS3 membrane protein, TerC HLB41_25115 ENOG4106FN3 tellurium resistance protein HLB41_25120 ENOG4106FN3 tellurium resistance protein HLB41_25125 ENOG4108N0M stress protein HLB41_25140 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HLB41_25155 ENOG4105DEU major facilitator superfamily HLB41_25170 ENOG41062JF Transcriptional regulator HLB41_25210 ENOG4105D2X ABC transporter substrate-binding protein HLB41_25215 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HLB41_25235 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HLB41_25240 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HLB41_25245 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase HLB41_25250 ENOG4105C9U ATP-dependent DNA helicase RecQ HLB41_25265 ENOG4105CI1 PTS System HLB41_25275 ENOG4105DNP FAD linked oxidase domain protein HLB41_25285 ENOG4108W63 CRP FNR family transcriptional regulator HLB41_25290 ENOG4105C5B carbamate kinase HLB41_25300 ENOG4105DBV ornithine carbamoyltransferase HLB41_25315 ENOG4105C8Q Methyl-accepting chemotaxis HLB41_25320 ENOG4105CDA abc transporter atp-binding protein HLB41_25325 ENOG4105EAB amino acid AbC transporter HLB41_25330 ENOG4105E5Q amino acid AbC transporter HLB41_25345 ENOG4105D2S major facilitator superfamily HLB41_25350 ENOG410756H nucleotidyltransferase HLB41_25370 ENOG4105BZU Histidine kinase HLB41_25385 ENOG4106UIA HLB41_25390 ENOG4106UIA HLB41_25410 ENOG4108V5C ABC transporter HLB41_25415 ENOG4105DQ5 transport system permease protein HLB41_25420 ENOG4105EHG Permease protein HLB41_25440 ENOG4105D3R alkyl hydroperoxide reductase HLB41_25460 ENOG4105DFD Na H antiporter HLB41_25470 ENOG4105DTQ mandelate racemase muconate lactonizing HLB41_25485 ENOG4108W15 Protein of unknown function (DUF1456) HLB41_25505 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HLB41_25510 ENOG4105D9N nucleoside HLB41_25540 ENOG4105KPY Small multidrug resistance protein HLB41_25545 ENOG4105C26 Dehydrogenase HLB41_25555 ENOG4108JPW Aminotransferase HLB41_25565 ENOG4105CBD Diacylglycerol kinase HLB41_25575 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HLB41_25585 ENOG4107I77 yiaA/B two helix domain HLB41_25590 ENOG410834F Transcriptional regulator HLB41_25610 ENOG4105D01 (LipO)protein HLB41_25615 ENOG4108UMI ABC transporter, permease HLB41_25620 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HLB41_25625 ENOG4108W2Y isochorismatase HLB41_25645 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HLB41_25650 ENOG4105C4R Atp-dependent dna helicase HLB41_25675 ENOG4105C12 Phosphoribosylglycinamide synthetase HLB41_25680 ENOG4105DC1 bifunctional purine biosynthesis protein purh HLB41_25685 ENOG4108V3E phosphoribosylglycinamide formyltransferase HLB41_25710 ENOG4105VR9 phosphoribosylformylglycinamidine synthase HLB41_25720 ENOG4105C83 adenylosuccinate lyase HLB41_25725 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HLB41_25730 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HLB41_25760 ENOG4105SX7 Transporter HLB41_25780 ENOG4108SHN Glycosyl transferase, family 2 HLB41_25790 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) HLB41_25800 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HLB41_25830 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HLB41_25875 ENOG4107ZXU DSBA oxidoreductase HLB41_25900 ENOG4105BZU Histidine kinase HLB41_25910 ENOG4105C7N Xanthine uracil vitamin C permease HLB41_25915 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HLB41_25930 ENOG4108TYN CAAX amino terminal protease family protein HLB41_25945 ENOG4105C5H ABC transporter HLB41_25950 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HLB41_25955 ENOG410801F ribosomal-protein-alanine acetyltransferase HLB41_25960 ENOG41072GX Peptidase M22 Glycoprotease HLB41_25965 ENOG4105K8N protein family UPF0079, ATPase HLB41_26070 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) HLB41_26080 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HLB41_26085 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein HLB41_26110 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) HLB41_26115 ENOG4105CPF Cell wall formation (By similarity) HLB41_26120 ENOG4108SC4 )-transporter HLB41_26125 ENOG4105CUB amino acid HLB41_26135 ENOG4105ERH Fumarylacetoacetate hydrolase HLB41_26140 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HLB41_26170 ENOG410667J hydrolase HLB41_26175 ENOG4108JQ7 (ABC) transporter HLB41_26180 ENOG4105C3U ABC transporter HLB41_26185 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HLB41_26195 ENOG4105DEF Extracellular solute-binding protein, family 5 HLB41_26205 ENOG4105C5H ABC transporter HLB41_26225 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) HLB41_26240 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) HLB41_26260 ENOG4105F6E Acyl-transferase HLB41_26280 ENOG4105EGI Transcriptional regulator HLB41_26290 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family HLB41_26295 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HLB41_26300 ENOG4105E0C molybdate abc transporter HLB41_26310 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HLB41_26325 ENOG4108J59 Extracellular solute-binding protein, family 5 HLB41_26330 ENOG4108J59 Extracellular solute-binding protein, family 5 HLB41_26360 ENOG4108JQ7 (ABC) transporter HLB41_26365 ENOG4105C3U ABC transporter HLB41_26370 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HLB41_26375 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HLB41_26390 ENOG4105C2C drug resistance transporter, Bcr CflA HLB41_26405 ENOG4105IQ5 FAD linked oxidase domain protein HLB41_26415 ENOG4105CB2 alcohol dehydrogenase HLB41_26420 ENOG4105D01 (LipO)protein HLB41_26425 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HLB41_26430 ENOG4108UMI ABC transporter, permease HLB41_26435 ENOG4108PSK reductase HLB41_26510 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HLB41_26525 ENOG4107U5W ybbr family HLB41_26530 ENOG4105C8B TIGR00159 family HLB41_26610 ENOG4108NMV polysaccharide deacetylase HLB41_26625 ENOG4105D1F ATP-binding protein HLB41_26650 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HLB41_26655 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HLB41_26660 ENOG4108JJB ABC transporter HLB41_26665 ENOG4108JJB ABC transporter HLB41_26700 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HLB41_26710 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HLB41_26840 ENOG4105XPM ribosomal protein HLB41_26855 ENOG4107Y49 methyltransferase HLB41_26880 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HLB41_26895 ENOG4105QIV RNA polymerase HLB41_26900 ENOG4105M0M Tetracycline resistance protein HLB41_26905 ENOG4105C2N RNA methyltransferase TrmH family group 3 HLB41_26920 ENOG4105D7W serine acetyltransferase HLB41_26935 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HLB41_26940 ENOG4105CTP PilT protein domain protein HLB41_26945 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HLB41_26950 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HLB41_26965 ENOG4108Z0C Uvrb UvrC protein HLB41_27055 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HLB41_27065 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HLB41_27070 ENOG4105KRF dihydroneopterin aldolase HLB41_27075 ENOG4105EEI dihydropteroate synthase HLB41_27080 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 HLB41_27085 ENOG4105DDQ anthranilate synthase HLB41_27090 ENOG4105CRQ synthase (Component I) HLB41_27095 ENOG4105C6T cysteine synthase HLB41_27110 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HLB41_27115 ENOG4108UGV hypoxanthine phosphoribosyltransferase HLB41_27120 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HLB41_27140 ENOG41060GV RNA binding s1 domain protein HLB41_27155 ENOG4105VYY sporulation protein yabp HLB41_27160 ENOG41082I2 s4 domain protein HLB41_27165 ENOG4108IY2 MazG family HLB41_27175 ENOG4108M14 stage v sporulation protein t HLB41_27180 ENOG4108JA2 transcriptioN-repair coupling factor HLB41_27190 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HLB41_27210 ENOG4105KME endoribonuclease L-psp HLB41_27215 ENOG4105DFT pur operon repressor HLB41_27230 ENOG4105C59 p-type ATPase HLB41_27235 ENOG4105VPX protein, conserved in bacteria HLB41_27240 ENOG4105DSE periplasmic solute binding protein HLB41_27310 ENOG4105K63 Thioredoxin HLB41_27320 ENOG4105EAB amino acid AbC transporter HLB41_27325 ENOG4105E5Q amino acid AbC transporter HLB41_27330 ENOG4105CDA abc transporter atp-binding protein HLB41_27340 ENOG4107R16 Multicopper oxidase HLB41_27345 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLB41_27350 ENOG4105BZU Histidine kinase HLB41_27360 ENOG4108ZRV stage ii sporulation protein p HLB41_27370 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) HLB41_27505 ENOG4105EKQ RNA-directed DNA polymerase HLB41_27525 ENOG4105EKQ RNA-directed DNA polymerase HLB41_27575 ENOG4108IMY Transcriptional regulator HLB41_27610 ENOG4107QYX exodeoxyribonuclease v alpha HLB41_27615 ENOG4105VTR Integrase HLB41_27650 ENOG4105W5Q DNA repair protein (RadC HLB41_27725 ENOG4108M1A Chitin-binding protein HLB41_27740 ENOG4107SDU Methyl-accepting chemotaxis HLB41_27760 ENOG4105K4H Nlp p60 protein HLB41_27800 ENOG41080HT Transcriptional regulator, arsr family HLB41_27825 ENOG41075D4 Aminoglycoside 6-adenylyltransferase HLB41_27925 ENOG4105EKQ RNA-directed DNA polymerase HLB41_27945 ENOG4105EKQ RNA-directed DNA polymerase HLB41_28005 ENOG4105EKQ RNA-directed DNA polymerase HLB41_28065 ENOG4105EKQ RNA-directed DNA polymerase HLB41_28070 ENOG4105CNU cell division protein FtsK HLB41_28100 ENOG4105D7V transposase HLB41_28260 ENOG41085FC arsR family transcriptional regulator HLB41_28265 ENOG4105CAY ferredoxin--nadp reductase HLB41_28275 ENOG4105H3G oxidoreductase HLB41_28285 ENOG4105CN5 Metallo-Beta-Lactamase HLB41_28290 ENOG4107YZX Universal stress protein HLB41_28295 ENOG4105CHH sulfate transporter HLB41_28315 ENOG4105CHH sulfate transporter HLB41_28330 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HLB41_28350 ENOG41082YX Transcriptional regulator, arsr family HLB41_28355 ENOG4105D6J arsenicaL-resistance protein HLB41_28375 ENOG4105C3M thioredoxin reductase HLB41_28445 ENOG4105EKQ RNA-directed DNA polymerase HLB41_28525 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HLB41_28540 ENOG4105E2A Dehydrogenase HLB41_28545 ENOG4105KVH Transcriptional regulator HLB41_28555 ENOG4108QBQ Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione (By similarity) HLB41_28575 ENOG4105C4W S-formylglutathione hydrolase HLB41_28580 ENOG4105D9M gamma-glutamylcysteine synthetase HLB41_28585 ENOG4108B31 Spore germination protein HLB41_28620 ENOG4105C4W S-formylglutathione hydrolase HLB41_28635 ENOG4105D9M gamma-glutamylcysteine synthetase HLB41_28640 ENOG4105D9M gamma-glutamylcysteine synthetase HLB41_28665 ENOG41067QW Transcriptional regulator HLB41_28675 ENOG4105DHF Membrane HLB41_28745 ENOG4105KRN Transcriptional regulator, abrb family HLB41_28755 ENOG4108FPN Integrase HLB41_28760 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HLB41_28765 ENOG4105ZX1 Transposase C HLB41_28775 ENOG4108FPN Integrase HLB41_28780 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HLB41_28805 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HLB41_28835 ENOG4108J59 Extracellular solute-binding protein, family 5 HLB41_28850 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HLB41_28930 ENOG4105W1Y Transcriptional regulator HLB41_28960 ENOG4108IBT Inherit from COG: transposase HLB41_28980 ENOG4105KVH Transcriptional regulator HLB41_28990 ENOG4105C4W S-formylglutathione hydrolase HLB41_29000 ENOG4105D9M gamma-glutamylcysteine synthetase HLB41_29020 ENOG4108NHD germination protein HLB41_29030 ENOG4108W2Y isochorismatase HLB41_29040 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLB41_29090 ENOG4105D6J arsenicaL-resistance protein HLB41_29095 ENOG41082YX Transcriptional regulator, arsr family HLB41_29115 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HLB41_29125 ENOG41067QW Transcriptional regulator HLB41_29130 ENOG4105CJ3 phosphate transporter HLB41_29135 ENOG41085FC arsR family transcriptional regulator HLB41_29150 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes