locus-tag	class	description
HLB41_00010	COG4466	Protein conserved in bacteria
HLB41_00030	COG0084	hydrolase, TatD family'
HLB41_00040	COG2002	toxin-antitoxin pair type II binding
HLB41_00045	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HLB41_00055	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HLB41_00065	COG1774	PSP1 C-terminal conserved region
HLB41_00070	COG0470	DNA polymerase III
HLB41_00080	COG1982	Orn Lys Arg decarboxylase major
HLB41_00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HLB41_00145	COG0590	tRNA wobble adenosine to inosine editing
HLB41_00150	COG1335	isochorismatase
HLB41_00155	COG1428	Deoxynucleoside kinase
HLB41_00160	COG1428	Deoxynucleoside kinase
HLB41_00190	COG1686	Belongs to the peptidase S11 family
HLB41_00195	COG0517	IMP dehydrogenase activity
HLB41_00195	COG0516	GMP reductase activity
HLB41_00230	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HLB41_00235	COG0187	DNA topoisomerase II activity
HLB41_00245	COG2501	S4 domain
HLB41_00250	COG0592	DNA-directed DNA polymerase activity
HLB41_00260	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HLB41_00275	COG1847	R3H domain protein
HLB41_00300	COG1192	Involved in chromosome partitioning
HLB41_00305	COG1475	DNA binding
HLB41_00315	COG0668	transmembrane transport
HLB41_00320	COG4481	Protein conserved in bacteria
HLB41_00325	COG0012	GTP binding
HLB41_00345	COG4241	membrane
HLB41_00350	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HLB41_00360	COG0305	Participates in initiation and elongation during chromosome replication
HLB41_00390	COG0745	RESPONSE REGULATOR receiver
HLB41_00395	COG5002	protein histidine kinase activity
HLB41_00405	COG4853	Protein conserved in bacteria
HLB41_00410	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HLB41_00415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLB41_00430	COG5002	protein histidine kinase activity
HLB41_00440	COG1164	Oligoendopeptidase f
HLB41_00460	COG1272	protein, Hemolysin III
HLB41_00465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HLB41_00485	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HLB41_00490	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLB41_00495	COG2814	Major facilitator Superfamily
HLB41_00500	COG3275	phosphorelay sensor kinase activity
HLB41_00520	COG0628	permease
HLB41_00525	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HLB41_00525	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HLB41_00530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLB41_00535	COG1309	transcriptional regulator
HLB41_00540	COG0488	(ABC) transporter
HLB41_00545	COG0463	Glycosyl transferase, family 2
HLB41_00550	COG4485	Bacterial membrane protein, YfhO
HLB41_00560	COG1216	Glycosyl transferase, family 2
HLB41_00570	COG1216	Glycosyl transferase, family 2
HLB41_00575	COG1607	acyl-coa hydrolase
HLB41_00585	COG0840	transmembrane signaling receptor activity
HLB41_00600	COG0438	transferase activity, transferring glycosyl groups
HLB41_00610	COG0477	Major facilitator Superfamily
HLB41_00615	COG3279	Response regulator of the LytR AlgR family
HLB41_00620	COG1966	Carbon starvation protein
HLB41_00625	COG2879	small protein
HLB41_00630	COG3706	GGDEF domain
HLB41_00635	COG0351	phosphomethylpyrimidine kinase
HLB41_00640	COG4585	Histidine kinase
HLB41_00640	COG2203	Gaf domain
HLB41_00645	COG2197	response regulator
HLB41_00655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLB41_00660	COG1011	Hydrolase
HLB41_00670	COG2873	o-acetylhomoserine
HLB41_00680	COG0460	homoserine dehydrogenase
HLB41_00690	COG1609	Transcriptional regulator
HLB41_00695	COG2755	lipolytic protein G-D-S-L family
HLB41_00700	COG1131	(ABC) transporter
HLB41_00705	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HLB41_00715	COG2814	Major facilitator Superfamily
HLB41_00720	COG0561	phosphatase activity
HLB41_00725	COG2233	PERMEase
HLB41_00730	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HLB41_00740	COG2363	Small membrane protein
HLB41_00750	COG3773	Cell wall hydrolase
HLB41_00765	COG0280	phosphate acetyltransferase
HLB41_00785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB41_00790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB41_00795	COG1120	ATPase activity
HLB41_00800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLB41_00805	COG1078	dGTPase activity
HLB41_00815	COG1994	Peptidase M50
HLB41_00825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLB41_00830	COG0584	glycerophosphoryl diester phosphodiesterase
HLB41_00835	COG0789	Transcriptional regulator
HLB41_00840	COG2814	Major facilitator Superfamily
HLB41_00865	COG1619	proteins homologs of microcin C7 resistance protein MccF
HLB41_00870	COG4506	Protein conserved in bacteria
HLB41_00880	COG1595	DNA-templated transcription, initiation
HLB41_00900	COG2234	aminopeptidase activity
HLB41_00910	COG0024	Methionine aminopeptidase
HLB41_00915	COG1131	(ABC) transporter
HLB41_00920	COG0842	Transport permease protein
HLB41_00925	COG4585	Histidine kinase
HLB41_00930	COG2197	response regulator
HLB41_00935	COG3227	Zinc metalloprotease (Elastase)
HLB41_00950	COG3300	MHYT domain
HLB41_00950	COG5001	Diguanylate cyclase
HLB41_00960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLB41_00965	COG2181	nitrate reductase activity
HLB41_00965	COG0247	lactate metabolic process
HLB41_00970	COG0183	Belongs to the thiolase family
HLB41_00975	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLB41_00980	COG1960	acyl-CoA dehydrogenase activity
HLB41_00985	COG1960	acyl-CoA dehydrogenase activity
HLB41_01005	COG4821	SIS domain
HLB41_01025	COG1494	fructose-1,6-bisphosphatase
HLB41_01030	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HLB41_01065	COG0009	L-threonylcarbamoyladenylate synthase
HLB41_01080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLB41_01085	COG2259	Doxx family
HLB41_01100	COG0698	ribose 5-phosphate isomerase
HLB41_01135	COG0356	it plays a direct role in the translocation of protons across the membrane
HLB41_01185	COG5001	Diguanylate cyclase
HLB41_01185	COG3300	MHYT domain
HLB41_01200	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLB41_01220	COG0839	Belongs to the complex I subunit 6 family
HLB41_01230	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HLB41_01235	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLB41_01240	COG1007	ATP synthesis coupled electron transport
HLB41_01245	COG4836	Membrane
HLB41_01260	COG2385	sporulation resulting in formation of a cellular spore
HLB41_01265	COG4555	ABC transporter
HLB41_01280	COG0739	heme binding
HLB41_01290	COG1609	Transcriptional regulator
HLB41_01305	COG0489	protein tyrosine kinase activity
HLB41_01310	COG3944	biosynthesis protein
HLB41_01315	COG0489	protein tyrosine kinase activity
HLB41_01320	COG4464	protein tyrosine phosphatase activity
HLB41_01325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HLB41_01330	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HLB41_01335	COG1215	transferase activity, transferring glycosyl groups
HLB41_01350	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HLB41_01355	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HLB41_01365	COG0438	transferase activity, transferring glycosyl groups
HLB41_01370	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HLB41_01385	COG1091	dTDP-4-dehydrorhamnose reductase activity
HLB41_01400	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HLB41_01405	COG0745	RESPONSE REGULATOR receiver
HLB41_01410	COG5002	protein histidine kinase activity
HLB41_01435	COG1136	(ABC) transporter
HLB41_01440	COG0577	efflux transmembrane transporter activity
HLB41_01480	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HLB41_01485	COG4715	Zinc finger, swim domain protein
HLB41_01510	COG1388	LysM domain
HLB41_01510	COG3584	3D domain protein
HLB41_01515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLB41_01520	COG1215	transferase activity, transferring glycosyl groups
HLB41_01530	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HLB41_01535	COG1388	LysM domain
HLB41_01535	COG0791	NLP P60 protein
HLB41_01545	COG1368	sulfuric ester hydrolase activity
HLB41_01555	COG2389	metal-binding protein
HLB41_01565	COG1620	l-lactate permease
HLB41_01575	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HLB41_01580	COG1294	oxidase, subunit
HLB41_01585	COG1271	oxidase subunit
HLB41_01595	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HLB41_01600	COG0583	DNA-binding transcription factor activity
HLB41_01605	COG1511	domain protein
HLB41_01635	COG1301	dicarboxylic acid transport
HLB41_01640	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLB41_01650	COG1447	Phosphotransferase system cellobiose-specific component IIA
HLB41_01670	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLB41_01675	COG1447	Phosphotransferase system cellobiose-specific component IIA
HLB41_01680	COG1486	melibiose metabolic process
HLB41_01700	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HLB41_01700	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HLB41_01710	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HLB41_01715	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HLB41_01720	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HLB41_01725	COG1316	TRANSCRIPTIONal
HLB41_01730	COG1739	Uncharacterized protein family UPF0029
HLB41_01735	COG1307	EDD domain protein, DegV family
HLB41_01740	COG1733	regulation of RNA biosynthetic process
HLB41_01745	COG0791	NLP P60 protein
HLB41_01750	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HLB41_01755	COG1040	competence protein
HLB41_01760	COG1278	Cold shock
HLB41_01765	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HLB41_01795	COG1131	(ABC) transporter
HLB41_01820	COG2884	Cell division ATP-binding protein ftsE
HLB41_01825	COG2177	Part of the ABC transporter FtsEX involved in
HLB41_01830	COG0793	Belongs to the peptidase S41A family
HLB41_01830	COG3409	Peptidoglycan-binding domain 1 protein
HLB41_01835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLB41_01840	COG1132	(ABC) transporter
HLB41_01855	COG0655	NAD(P)H dehydrogenase (quinone) activity
HLB41_01865	COG0583	DNA-binding transcription factor activity
HLB41_01885	COG0789	Transcriptional regulator
HLB41_01900	COG0556	nucleotide-excision repair
HLB41_01905	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HLB41_01910	COG1950	PFAM Membrane protein of
HLB41_01930	COG0110	maltose O-acetyltransferase activity
HLB41_01935	COG0457	Tetratricopeptide repeat
HLB41_01940	COG0492	ferredoxin-NADP+ reductase activity
HLB41_01950	COG1051	belongs to the nudix hydrolase family
HLB41_01960	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HLB41_01970	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLB41_01980	COG2323	membrane
HLB41_01995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HLB41_02025	COG4585	Histidine kinase
HLB41_02030	COG4152	abc transporter atp-binding protein
HLB41_02035	COG1668	transmembrane transport
HLB41_02045	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HLB41_02060	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HLB41_02095	COG1346	cytolysis
HLB41_02100	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HLB41_02105	COG1647	Serine aminopeptidase, S33
HLB41_02110	COG0557	exoribonuclease II activity
HLB41_02185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLB41_02190	COG0488	(ABC) transporter
HLB41_02240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HLB41_02245	COG1252	NADH dehydrogenase
HLB41_02255	COG1733	regulation of RNA biosynthetic process
HLB41_02260	COG2814	Major facilitator Superfamily
HLB41_02265	COG0656	L-ascorbic acid biosynthetic process
HLB41_02280	COG2910	NAD(P)H-binding
HLB41_02285	COG1115	amino acid carrier protein
HLB41_02290	COG1115	amino acid carrier protein
HLB41_02295	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HLB41_02300	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HLB41_02310	COG1528	Iron-storage protein
HLB41_02320	COG1611	Belongs to the LOG family
HLB41_02335	COG0783	Belongs to the Dps family
HLB41_02340	COG1115	amino acid carrier protein
HLB41_02345	COG0490	domain, Protein
HLB41_02350	COG0475	glutathione-regulated potassium exporter activity
HLB41_02355	COG0586	Pfam SNARE associated Golgi protein
HLB41_02370	COG1741	Belongs to the pirin family
HLB41_02375	COG3227	Zinc metalloprotease (Elastase)
HLB41_02380	COG2151	metal-sulfur cluster biosynthetic enzyme
HLB41_02385	COG0840	transmembrane signaling receptor activity
HLB41_02425	COG5002	protein histidine kinase activity
HLB41_02430	COG0745	RESPONSE REGULATOR receiver
HLB41_02435	COG1376	ErfK ybiS ycfS ynhG family protein
HLB41_02445	COG0586	Pfam SNARE associated Golgi protein
HLB41_02485	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLB41_02515	COG0531	amino acid
HLB41_02525	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HLB41_02530	COG2814	Major facilitator Superfamily
HLB41_02545	COG0840	transmembrane signaling receptor activity
HLB41_02550	COG0011	TIGRFAM Protein of
HLB41_02565	COG1686	Belongs to the peptidase S11 family
HLB41_02575	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLB41_02575	COG1024	Enoyl-CoA hydratase
HLB41_02580	COG0183	Belongs to the thiolase family
HLB41_02585	COG1960	acyl-CoA dehydrogenase activity
HLB41_02590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB41_02595	COG1309	transcriptional regulator
HLB41_02635	COG1393	Belongs to the ArsC family
HLB41_02645	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HLB41_02650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLB41_02665	COG2011	ABC-type metal ion transport system permease component
HLB41_02670	COG1464	Belongs to the NlpA lipoprotein family
HLB41_02675	COG1464	Belongs to the NlpA lipoprotein family
HLB41_02680	COG0396	ATPase activity
HLB41_02685	COG0719	Fe-S assembly protein
HLB41_02690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HLB41_02695	COG0822	iron-sulfur transferase activity
HLB41_02700	COG0719	Fe-S assembly protein
HLB41_02705	COG0737	Belongs to the 5'-nucleotidase family
HLB41_02710	COG3377	Domain of unknown function (DUF1805)
HLB41_02720	COG0739	heme binding
HLB41_02745	COG4377	Putative membrane peptidase family (DUF2324)
HLB41_02750	COG0789	Transcriptional regulator
HLB41_02760	COG4470	Protein conserved in bacteria
HLB41_02780	COG1494	fructose-1,6-bisphosphatase
HLB41_02785	COG2445	Protein of unknown function DUF86
HLB41_02795	COG0647	UMP catabolic process
HLB41_02805	COG2249	NAD(P)H dehydrogenase (quinone) activity
HLB41_02815	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HLB41_02820	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HLB41_02830	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HLB41_02835	COG4837	Protein of unknown function (DUF1462)
HLB41_02875	COG2824	Alkylphosphonate utilization operon protein PhnA
HLB41_02880	COG0390	transport system, permease component
HLB41_02895	COG1252	NADH dehydrogenase
HLB41_02910	COG0316	Belongs to the HesB IscA family
HLB41_02930	COG1683	Conserved Protein
HLB41_02945	COG3708	Transcriptional regulator
HLB41_02960	COG1252	NADH dehydrogenase
HLB41_02975	COG3584	3D domain protein
HLB41_02985	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HLB41_02990	COG2076	Multidrug Resistance protein
HLB41_03010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLB41_03015	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HLB41_03020	COG1268	BioY protein
HLB41_03030	COG2050	protein possibly involved in aromatic compounds catabolism
HLB41_03050	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HLB41_03055	COG5018	Exonuclease
HLB41_03075	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HLB41_03085	COG2267	carboxylic ester hydrolase activity
HLB41_03090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HLB41_03095	COG1522	sequence-specific DNA binding
HLB41_03100	COG0436	Aminotransferase
HLB41_03105	COG1098	S1 RNA binding domain
HLB41_03110	COG2155	Conserved Protein
HLB41_03125	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HLB41_03130	COG1285	pathogenesis
HLB41_03165	COG0544	peptidyl-prolyl cis-trans isomerase activity
HLB41_03265	COG1404	Belongs to the peptidase S8 family
HLB41_03285	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HLB41_03295	COG0058	SHG alpha-glucan phosphorylase activity
HLB41_03320	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HLB41_03325	COG1575	Belongs to the MenA family. Type 1 subfamily
HLB41_03330	COG1169	isochorismate synthase
HLB41_03340	COG0596	Alpha beta hydrolase
HLB41_03345	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HLB41_03355	COG4948	Mandelate Racemase Muconate Lactonizing
HLB41_03375	COG3964	amidohydrolase
HLB41_03395	COG2188	Transcriptional regulator
HLB41_03420	COG0577	efflux transmembrane transporter activity
HLB41_03425	COG1136	(ABC) transporter
HLB41_03430	COG0577	efflux transmembrane transporter activity
HLB41_03435	COG0577	efflux transmembrane transporter activity
HLB41_03440	COG2205	protein histidine kinase activity
HLB41_03445	COG0745	RESPONSE REGULATOR receiver
HLB41_03450	COG0640	Transcriptional regulator
HLB41_03455	COG5658	integral membrane protein
HLB41_03460	COG3708	Transcriptional regulator
HLB41_03460	COG2207	Transcriptional regulator
HLB41_03465	COG1136	(ABC) transporter
HLB41_03470	COG0577	efflux transmembrane transporter activity
HLB41_03480	COG0586	Pfam SNARE associated Golgi protein
HLB41_03495	COG1136	(ABC) transporter
HLB41_03500	COG0577	efflux transmembrane transporter activity
HLB41_03540	COG1597	lipid kinase activity
HLB41_03570	COG0745	RESPONSE REGULATOR receiver
HLB41_03575	COG5002	protein histidine kinase activity
HLB41_03605	COG1842	Phage shock protein A
HLB41_03625	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLB41_03640	COG1294	oxidase, subunit
HLB41_03645	COG1271	oxidase subunit
HLB41_03650	COG0288	reversible hydration of carbon dioxide
HLB41_03660	COG1854	S-ribosylhomocysteine lyase activity
HLB41_03690	COG0494	nUDIX hydrolase
HLB41_03715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLB41_03720	COG1116	anion transmembrane transporter activity
HLB41_03725	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLB41_03740	COG1368	sulfuric ester hydrolase activity
HLB41_03745	COG2267	carboxylic ester hydrolase activity
HLB41_03760	COG3852	Histidine kinase
HLB41_03765	COG5002	protein histidine kinase activity
HLB41_03810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLB41_03830	COG0438	transferase activity, transferring glycosyl groups
HLB41_03835	COG0671	phosphoesterase, PA-phosphatase related
HLB41_03840	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HLB41_03845	COG2267	carboxylic ester hydrolase activity
HLB41_03860	COG1794	racemase activity, acting on amino acids and derivatives
HLB41_03875	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HLB41_03880	COG1242	4 iron, 4 sulfur cluster binding
HLB41_03900	COG1136	(ABC) transporter
HLB41_03910	COG0582	viral genome integration into host DNA
HLB41_03915	COG0490	domain, Protein
HLB41_03920	COG0475	glutathione-regulated potassium exporter activity
HLB41_03925	COG2814	Major facilitator Superfamily
HLB41_03965	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HLB41_03975	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLB41_04000	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HLB41_04005	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HLB41_04015	COG0303	'Molybdopterin
HLB41_04020	COG1763	Mo-molybdopterin cofactor biosynthetic process
HLB41_04025	COG0314	molybdopterin synthase activity
HLB41_04050	COG1329	Transcriptional regulator
HLB41_04070	COG3832	glyoxalase III activity
HLB41_04080	COG2814	Major facilitator Superfamily
HLB41_04085	COG2081	HI0933 family
HLB41_04090	COG2244	polysaccharide biosynthetic process
HLB41_04095	COG1187	pseudouridine synthase activity
HLB41_04100	COG1349	DNA-binding transcription factor activity
HLB41_04105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLB41_04115	COG1523	belongs to the glycosyl hydrolase 13 family
HLB41_04120	COG0510	thiamine kinase activity
HLB41_04135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB41_04145	COG1363	Peptidase, m42
HLB41_04150	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HLB41_04155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLB41_04165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLB41_04175	COG1388	LysM domain
HLB41_04175	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLB41_04180	COG1674	ftsk spoiiie
HLB41_04195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLB41_04220	COG2309	aminopeptidase activity
HLB41_04230	COG3118	belongs to the thioredoxin family
HLB41_04235	COG4851	CamS sex pheromone cAM373 precursor
HLB41_04240	COG1605	Chorismate mutase
HLB41_04240	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HLB41_04245	COG1609	Transcriptional regulator
HLB41_04280	COG0666	response to abiotic stimulus
HLB41_04290	COG0745	RESPONSE REGULATOR receiver
HLB41_04305	COG0123	including yeast histone deacetylase and acetoin utilization protein
HLB41_04310	COG0517	IMP dehydrogenase activity
HLB41_04315	COG0454	-acetyltransferase
HLB41_04320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLB41_04325	COG0110	maltose O-acetyltransferase activity
HLB41_04360	COG0626	cystathionine gamma-synthase activity
HLB41_04365	COG1956	GAF domain-containing protein
HLB41_04370	COG1309	transcriptional regulator
HLB41_04375	COG0697	spore germination
HLB41_04380	COG0583	DNA-binding transcription factor activity
HLB41_04390	COG1104	cysteine desulfurase activity
HLB41_04405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLB41_04415	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HLB41_04430	COG3874	Sporulation protein YtfJ
HLB41_04440	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HLB41_04445	COG0827	DNA restriction-modification system
HLB41_04470	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLB41_04510	COG0589	response to stress
HLB41_04515	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_04530	COG0662	Cupin 2, conserved barrel domain protein
HLB41_04535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLB41_04570	COG0006	proline dipeptidase activity
HLB41_04585	COG4109	DRTGG domain
HLB41_04600	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HLB41_04615	COG0587	DNA-directed DNA polymerase activity
HLB41_04620	COG0281	malic enzyme
HLB41_04625	COG1725	Transcriptional regulator
HLB41_04650	COG3030	protein affecting phage T7 exclusion by the F plasmid
HLB41_04655	COG0628	permease
HLB41_04665	COG0372	Belongs to the citrate synthase family
HLB41_04670	COG0538	isocitrate dehydrogenase activity
HLB41_04690	COG0745	RESPONSE REGULATOR receiver
HLB41_04695	COG5002	protein histidine kinase activity
HLB41_04700	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HLB41_04700	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HLB41_04710	COG1971	Probably functions as a manganese efflux pump
HLB41_04720	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HLB41_04725	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HLB41_04735	COG3611	Membrane attachment protein
HLB41_04740	COG1484	DNA-dependent DNA replication
HLB41_04755	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HLB41_04780	COG1363	Peptidase, m42
HLB41_04785	COG1309	transcriptional regulator
HLB41_04790	COG1566	PFAM secretion protein HlyD family protein
HLB41_04795	COG2814	Major facilitator Superfamily
HLB41_04810	COG1418	mRNA catabolic process
HLB41_04820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLB41_04860	COG1286	toxin biosynthetic process
HLB41_04865	COG1796	DNA polymerase
HLB41_04865	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HLB41_04875	COG1187	pseudouridine synthase activity
HLB41_04880	COG1114	Component of the transport system for branched-chain amino acids
HLB41_04885	COG5386	Cell surface protein
HLB41_04895	COG5386	Cell surface protein
HLB41_04910	COG1120	ATPase activity
HLB41_04915	COG4509	Sortase family
HLB41_04925	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HLB41_04930	COG4895	conserved protein (DUF2196)
HLB41_04940	COG0745	RESPONSE REGULATOR receiver
HLB41_04945	COG2205	protein histidine kinase activity
HLB41_04950	COG1131	(ABC) transporter
HLB41_04975	COG2318	DinB family
HLB41_05000	COG0318	PFAM AMP-dependent synthetase and ligase
HLB41_05005	COG1309	transcriptional regulator
HLB41_05010	COG1024	Enoyl-CoA hydratase
HLB41_05015	COG2086	electron transfer activity
HLB41_05020	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HLB41_05025	COG3118	belongs to the thioredoxin family
HLB41_05035	COG1719	4-vinyl reductase, 4VR
HLB41_05040	COG2009	succinate dehydrogenase
HLB41_05045	COG1053	succinate dehydrogenase
HLB41_05050	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HLB41_05055	COG0824	Thioesterase
HLB41_05060	COG1876	peptidase activity
HLB41_05065	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HLB41_05070	COG1360	Flagellar Motor Protein
HLB41_05075	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HLB41_05080	COG4152	abc transporter atp-binding protein
HLB41_05085	COG1668	transmembrane transport
HLB41_05090	COG1959	2 iron, 2 sulfur cluster binding
HLB41_05100	COG0697	spore germination
HLB41_05105	COG1396	sequence-specific DNA binding
HLB41_05110	COG1983	PspC domain protein
HLB41_05115	COG0402	S-adenosylhomocysteine deaminase activity
HLB41_05120	COG2233	PERMEase
HLB41_05125	COG2197	response regulator
HLB41_05150	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HLB41_05215	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HLB41_05220	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HLB41_05225	COG1999	signal sequence binding
HLB41_05255	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HLB41_05265	COG2197	response regulator
HLB41_05275	COG1309	transcriptional regulator
HLB41_05295	COG5401	PFAM Sporulation and spore germination
HLB41_05310	COG0622	Phosphoesterase
HLB41_05355	COG0470	DNA polymerase III
HLB41_05355	COG1067	ATP-dependent peptidase activity
HLB41_05370	COG1764	response to oxidative stress
HLB41_05375	COG1846	Transcriptional regulator
HLB41_05385	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HLB41_05395	COG1587	Uroporphyrinogen-III synthase
HLB41_05400	COG0113	porphobilinogen synthase activity
HLB41_05410	COG1388	LysM domain
HLB41_05425	COG0285	dihydrofolate synthase activity
HLB41_05445	COG1077	Cell shape determining protein MreB Mrl
HLB41_05465	COG2894	cell division
HLB41_05470	COG0739	heme binding
HLB41_05475	COG1994	Peptidase M50
HLB41_05480	COG1530	ribonuclease E activity
HLB41_05490	COG2868	ribosomal protein
HLB41_05500	COG3290	protein histidine kinase activity
HLB41_05510	COG0745	RESPONSE REGULATOR receiver
HLB41_05515	COG5002	protein histidine kinase activity
HLB41_05520	COG1136	(ABC) transporter
HLB41_05525	COG0577	efflux transmembrane transporter activity
HLB41_05530	COG0577	efflux transmembrane transporter activity
HLB41_05535	COG0077	Prephenate dehydratase
HLB41_05540	COG2258	MOSC domain
HLB41_05545	COG1827	regulation of RNA biosynthetic process
HLB41_05550	COG1104	cysteine desulfurase activity
HLB41_05555	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HLB41_05560	COG0157	Belongs to the NadC ModD family
HLB41_05590	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HLB41_05620	COG1862	Preprotein translocase
HLB41_05630	COG2323	membrane
HLB41_05635	COG2244	polysaccharide biosynthetic process
HLB41_05645	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HLB41_05645	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HLB41_05650	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HLB41_05655	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HLB41_05655	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HLB41_05665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HLB41_05690	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HLB41_05700	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HLB41_05705	COG1959	2 iron, 2 sulfur cluster binding
HLB41_05710	COG1104	cysteine desulfurase activity
HLB41_05725	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HLB41_05745	COG0628	permease
HLB41_05775	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HLB41_05780	COG4122	O-methyltransferase activity
HLB41_05810	COG0768	penicillin binding
HLB41_05835	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HLB41_05840	COG0626	cystathionine gamma-synthase activity
HLB41_05845	COG1012	belongs to the aldehyde dehydrogenase family
HLB41_05845	COG1454	alcohol dehydrogenase
HLB41_05855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLB41_05895	COG2259	Doxx family
HLB41_05900	COG2514	catechol 2,3-dioxygenase activity
HLB41_05910	COG3186	Phenylalanine-4-hydroxylase
HLB41_05915	COG1404	Belongs to the peptidase S8 family
HLB41_05950	COG2267	carboxylic ester hydrolase activity
HLB41_05960	COG1785	Belongs to the alkaline phosphatase family
HLB41_05970	COG2357	RelA SpoT domain protein
HLB41_05975	COG0778	Nitroreductase
HLB41_06010	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HLB41_06015	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HLB41_06025	COG1534	Rna-binding protein
HLB41_06035	COG1713	HD superfamily hydrolase involved in NAD metabolism
HLB41_06040	COG0799	negative regulation of ribosome biogenesis
HLB41_06045	COG2226	methyltransferase
HLB41_06050	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HLB41_06055	COG1555	photosystem II stabilization
HLB41_06055	COG1596	polysaccharide export
HLB41_06060	COG2131	deaminase
HLB41_06065	COG2333	competence protein COMEC
HLB41_06065	COG0658	competence protein
HLB41_06075	COG1466	dna polymerase III delta subunit
HLB41_06100	COG1733	regulation of RNA biosynthetic process
HLB41_06105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HLB41_06135	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HLB41_06140	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HLB41_06145	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HLB41_06150	COG1610	YqeY-like protein
HLB41_06165	COG1702	phosphate starvation-inducible protein PhoH
HLB41_06170	COG1480	7TM receptor with intracellular HD hydrolase
HLB41_06180	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HLB41_06185	COG0295	cytidine deaminase activity
HLB41_06190	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HLB41_06205	COG0517	IMP dehydrogenase activity
HLB41_06215	COG1671	Belongs to the UPF0178 family
HLB41_06220	COG0358	DNA primase activity
HLB41_06225	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HLB41_06235	COG2384	SAM-dependent methyltransferase
HLB41_06240	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HLB41_06270	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLB41_06275	COG1121	(ABC) transporter
HLB41_06280	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLB41_06285	COG0735	belongs to the Fur family
HLB41_06300	COG5521	maltodextrose utilization protein MalA
HLB41_06310	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HLB41_06315	COG0477	Major facilitator Superfamily
HLB41_06325	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HLB41_06330	COG0573	inorganic phosphate transmembrane transporter activity
HLB41_06335	COG0573	inorganic phosphate transmembrane transporter activity
HLB41_06345	COG0704	Plays a role in the regulation of phosphate uptake
HLB41_06350	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HLB41_06355	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HLB41_06360	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HLB41_06365	COG4483	Protein conserved in bacteria
HLB41_06370	COG1940	carbohydrate kinase activity
HLB41_06380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB41_06400	COG0626	cystathionine gamma-synthase activity
HLB41_06405	COG0626	cystathionine gamma-synthase activity
HLB41_06410	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HLB41_06410	COG0646	methionine synthase
HLB41_06415	COG0646	methionine synthase
HLB41_06415	COG1410	methionine synthase
HLB41_06470	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HLB41_06475	COG1459	type II secretion system
HLB41_06525	COG2264	protein methyltransferase activity
HLB41_06550	COG2169	Transcriptional regulator
HLB41_06555	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HLB41_06585	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HLB41_06590	COG2169	Transcriptional regulator
HLB41_06630	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HLB41_06660	COG1725	Transcriptional regulator
HLB41_06665	COG1131	(ABC) transporter
HLB41_06700	COG2076	Multidrug Resistance protein
HLB41_06705	COG2076	Multidrug Resistance protein
HLB41_06715	COG1609	Transcriptional regulator
HLB41_06725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLB41_06760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLB41_06770	COG3872	metal-dependent enzyme
HLB41_06785	COG0006	proline dipeptidase activity
HLB41_06810	COG3854	ATPases associated with a variety of cellular activities
HLB41_06855	COG0511	ligase activity, forming carbon-carbon bonds
HLB41_06860	COG0439	Biotin carboxylase
HLB41_06865	COG1302	Protein conserved in bacteria
HLB41_06890	COG0142	geranyltranstransferase activity
HLB41_06900	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HLB41_06910	COG0497	DNA recombination
HLB41_06915	COG0750	zinc metalloprotease
HLB41_06930	COG3093	addiction module antidote protein HigA
HLB41_06935	COG0584	glycerophosphoryl diester phosphodiesterase
HLB41_06945	COG3829	transcription factor binding
HLB41_06945	COG3290	protein histidine kinase activity
HLB41_06950	COG0280	phosphate acetyltransferase
HLB41_06965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLB41_06970	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HLB41_06975	COG0022	dehydrogenase e1 component
HLB41_06980	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLB41_06985	COG0772	Belongs to the SEDS family
HLB41_06990	COG2323	membrane
HLB41_07010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB41_07015	COG0765	amino acid transport
HLB41_07020	COG1126	abc transporter atp-binding protein
HLB41_07025	COG4129	membrane
HLB41_07030	COG1376	ErfK ybiS ycfS ynhG family protein
HLB41_07045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLB41_07050	COG2195	Cleaves the N-terminal amino acid of tripeptides
HLB41_07060	COG1285	pathogenesis
HLB41_07090	COG1760	l-serine dehydratase
HLB41_07095	COG1760	l-serine dehydratase
HLB41_07100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HLB41_07105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB41_07110	COG0300	oxidoreductase activity
HLB41_07155	COG1522	sequence-specific DNA binding
HLB41_07165	COG0737	Belongs to the 5'-nucleotidase family
HLB41_07180	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HLB41_07195	COG2226	methyltransferase
HLB41_07195	COG1073	alpha beta
HLB41_07225	COG0307	riboflavin synthase, alpha
HLB41_07230	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HLB41_07230	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HLB41_07245	COG1073	alpha beta
HLB41_07250	COG0456	acetyltransferase
HLB41_07255	COG1609	Transcriptional regulator
HLB41_07260	COG2056	Na+-H+ antiporter family
HLB41_07265	COG0596	Alpha beta hydrolase
HLB41_07275	COG4085	toxin activity
HLB41_07275	COG1525	nuclease
HLB41_07275	COG0737	Belongs to the 5'-nucleotidase family
HLB41_07285	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HLB41_07285	COG0456	acetyltransferase
HLB41_07290	COG0656	L-ascorbic acid biosynthetic process
HLB41_07295	COG0667	Aldo Keto reductase
HLB41_07315	COG1300	Membrane
HLB41_07320	COG0735	belongs to the Fur family
HLB41_07330	COG4974	Belongs to the 'phage' integrase family
HLB41_07355	COG0598	Magnesium transport protein CorA
HLB41_07370	COG1846	Transcriptional regulator
HLB41_07390	COG1131	(ABC) transporter
HLB41_07395	COG1725	Transcriptional regulator
HLB41_07400	COG1686	Belongs to the peptidase S11 family
HLB41_07420	COG0733	neurotransmitter:sodium symporter activity
HLB41_07445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HLB41_07460	COG0697	spore germination
HLB41_07465	COG0561	phosphatase activity
HLB41_07470	COG4086	secreted protein
HLB41_07475	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HLB41_07480	COG0456	acetyltransferase
HLB41_07485	COG1547	Domain of unknown function (DUF309)
HLB41_07510	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HLB41_07520	COG2188	Transcriptional regulator
HLB41_07530	COG3711	transcriptional antiterminator
HLB41_07535	COG1263	PTS System
HLB41_07535	COG2190	(PTS) system
HLB41_07535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLB41_07560	COG0778	Nitroreductase
HLB41_07565	COG2199	diguanylate cyclase activity
HLB41_07565	COG2203	Gaf domain
HLB41_07575	COG2084	Dehydrogenase
HLB41_07610	COG0436	Aminotransferase
HLB41_07615	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HLB41_07635	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_07640	COG1695	Transcriptional regulator
HLB41_07675	COG0183	Belongs to the thiolase family
HLB41_07715	COG3842	ATPase activity
HLB41_07720	COG0366	Alpha amylase catalytic
HLB41_07730	COG2182	Extracellular solute-binding protein
HLB41_07735	COG1175	transmembrane transport
HLB41_07740	COG3833	ABC-type maltose transport systems, permease component
HLB41_07745	COG1609	Transcriptional regulator
HLB41_07750	COG0436	Aminotransferase
HLB41_07760	COG2205	protein histidine kinase activity
HLB41_07770	COG3209	COG3209 Rhs family protein
HLB41_07790	COG2814	Major facilitator Superfamily
HLB41_07835	COG1408	metallophosphoesterase
HLB41_07840	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_07845	COG2200	EAL domain
HLB41_07860	COG4703	Protein of unknown function (DUF1797)
HLB41_07870	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HLB41_07880	COG0517	IMP dehydrogenase activity
HLB41_07885	COG0583	DNA-binding transcription factor activity
HLB41_07905	COG0569	domain protein
HLB41_07910	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HLB41_07920	COG0561	phosphatase activity
HLB41_07935	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HLB41_07940	COG0022	dehydrogenase e1 component
HLB41_07990	COG1982	Orn Lys Arg decarboxylase major
HLB41_08010	COG0483	inositol monophosphate 1-phosphatase activity
HLB41_08035	COG4896	Protein conserved in bacteria
HLB41_08045	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HLB41_08050	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HLB41_08060	COG0772	Belongs to the SEDS family
HLB41_08065	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HLB41_08100	COG3336	cytochrome c oxidase
HLB41_08110	COG3344	reverse transcriptase
HLB41_08125	COG2340	Cysteine-rich secretory protein family
HLB41_08140	COG0406	alpha-ribazole phosphatase activity
HLB41_08145	COG3679	Belongs to the UPF0342 family
HLB41_08160	COG0742	ribosomal rna small subunit methyltransferase
HLB41_08170	COG3314	Sporulation integral membrane protein YlbJ
HLB41_08175	COG1752	Esterase of the alpha-beta hydrolase superfamily
HLB41_08180	COG3480	Lon protease (S16) C-terminal proteolytic domain
HLB41_08190	COG1399	metal-binding, possibly nucleic acid-binding protein
HLB41_08195	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HLB41_08210	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HLB41_08235	COG0768	penicillin binding
HLB41_08255	COG0772	Belongs to the SEDS family
HLB41_08275	COG0849	cell division
HLB41_08280	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HLB41_08290	COG1191	sigma factor activity
HLB41_08295	COG1191	sigma factor activity
HLB41_08300	COG1873	PFAM PRC-barrel domain
HLB41_08310	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HLB41_08315	COG1799	cell septum assembly
HLB41_08320	COG0762	integral membrane protein
HLB41_08325	COG2302	S4 RNA-binding domain
HLB41_08330	COG3599	regulation of cell shape
HLB41_08350	COG0564	pseudouridine synthase activity
HLB41_08415	COG3069	C4-dicarboxylate transmembrane transporter activity
HLB41_08425	COG0006	proline dipeptidase activity
HLB41_08435	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HLB41_08440	COG1561	YicC-like family, N-terminal region
HLB41_08460	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HLB41_08465	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HLB41_08480	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HLB41_08480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HLB41_08490	COG0631	protein serine/threonine phosphatase activity
HLB41_08495	COG2815	serine threonine protein kinase
HLB41_08495	COG0515	serine threonine protein kinase
HLB41_08505	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HLB41_08510	COG1564	THIamine pyrophosphokinase
HLB41_08525	COG1302	Protein conserved in bacteria
HLB41_08530	COG1461	Dihydroxyacetone kinase
HLB41_08535	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HLB41_08550	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HLB41_08555	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_08560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HLB41_08570	COG1196	nuclear chromosome segregation
HLB41_08575	COG0552	protein localization to endoplasmic reticulum
HLB41_08585	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HLB41_08595	COG1837	Belongs to the UPF0109 family
HLB41_08635	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HLB41_08640	COG0758	DNA mediated transformation
HLB41_08645	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HLB41_08655	COG4974	Belongs to the 'phage' integrase family
HLB41_08700	COG4589	Belongs to the CDS family
HLB41_08710	COG0750	zinc metalloprotease
HLB41_08730	COG0195	Participates in both transcription termination and antitermination
HLB41_08735	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HLB41_08740	COG1358	cellular component organization or biogenesis
HLB41_08750	COG1550	Protein conserved in bacteria
HLB41_08755	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HLB41_08765	COG0196	riboflavin kinase activity
HLB41_08780	COG0726	polysaccharide deacetylase
HLB41_08785	COG0612	Peptidase, M16
HLB41_08790	COG1873	PFAM PRC-barrel domain
HLB41_08795	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HLB41_08800	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HLB41_08805	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HLB41_08810	COG0527	aspartate kinase activity
HLB41_08820	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HLB41_08825	COG0740	serine-type endopeptidase activity
HLB41_08845	COG2188	Transcriptional regulator
HLB41_08870	COG0612	Peptidase, M16
HLB41_08875	COG0612	Peptidase, M16
HLB41_08880	COG0300	oxidoreductase activity
HLB41_08895	COG1426	Protein conserved in bacteria
HLB41_08900	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HLB41_08920	COG1692	metallophosphoesterase
HLB41_08925	COG2359	stage V sporulation protein S
HLB41_08935	COG0674	pyruvate-flavodoxin oxidoreductase activity
HLB41_08935	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HLB41_08940	COG1013	pyruvate-flavodoxin oxidoreductase activity
HLB41_08950	COG4550	Control of competence regulator ComK, YlbF/YmcA
HLB41_08975	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HLB41_08980	COG1368	sulfuric ester hydrolase activity
HLB41_08990	COG3773	Cell wall hydrolase
HLB41_08995	COG1404	Belongs to the peptidase S8 family
HLB41_09005	COG2723	6-phospho-beta-galactosidase activity
HLB41_09010	COG2188	Transcriptional regulator
HLB41_09020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLB41_09030	COG1346	cytolysis
HLB41_09050	COG1086	Polysaccharide biosynthesis protein
HLB41_09070	COG5001	Diguanylate cyclase
HLB41_09070	COG3300	MHYT domain
HLB41_09075	COG2267	carboxylic ester hydrolase activity
HLB41_09095	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HLB41_09100	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HLB41_09105	COG2169	Transcriptional regulator
HLB41_09110	COG0708	Exodeoxyribonuclease III
HLB41_09115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLB41_09120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB41_09125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB41_09130	COG1120	ATPase activity
HLB41_09135	COG2819	hydrolase of the alpha beta superfamily
HLB41_09145	COG1937	Protein conserved in bacteria
HLB41_09150	COG2608	mercury ion transmembrane transporter activity
HLB41_09155	COG2217	Heavy metal translocating P-type atpase
HLB41_09170	COG2116	formate transmembrane transporter activity
HLB41_09175	COG1408	metallophosphoesterase
HLB41_09185	COG1113	amino acid transport
HLB41_09195	COG2322	membrane
HLB41_09200	COG1979	alcohol dehydrogenase
HLB41_09205	COG1349	DNA-binding transcription factor activity
HLB41_09210	COG1105	Belongs to the carbohydrate kinase PfkB family
HLB41_09215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLB41_09215	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLB41_09215	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLB41_09220	COG1388	LysM domain
HLB41_09220	COG3584	3D domain protein
HLB41_09250	COG0464	growth
HLB41_09260	COG2860	membrane
HLB41_09265	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HLB41_09270	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HLB41_09275	COG0789	Transcriptional regulator
HLB41_09280	COG0174	glutamine synthetase
HLB41_09285	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HLB41_09320	COG0741	lytic transglycosylase activity
HLB41_09325	COG0739	heme binding
HLB41_09330	COG5632	N-Acetylmuramoyl-L-alanine amidase
HLB41_09330	COG3409	Peptidoglycan-binding domain 1 protein
HLB41_09330	COG1388	LysM domain
HLB41_09340	COG1695	Transcriptional regulator
HLB41_09360	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HLB41_09370	COG0737	Belongs to the 5'-nucleotidase family
HLB41_09375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB41_09385	COG3639	organic phosphonate transmembrane transporter activity
HLB41_09410	COG1132	(ABC) transporter
HLB41_09415	COG1132	(ABC) transporter
HLB41_09440	COG0730	response to heat
HLB41_09455	COG1346	cytolysis
HLB41_09465	COG0583	DNA-binding transcription factor activity
HLB41_09480	COG1131	(ABC) transporter
HLB41_09490	COG1473	amidohydrolase
HLB41_09500	COG0785	Cytochrome C biogenesis protein
HLB41_09505	COG4846	Membrane protein involved in cytochrome C biogenesis
HLB41_09555	COG0010	Belongs to the arginase family
HLB41_09560	COG1329	Transcriptional regulator
HLB41_09565	COG1902	pentaerythritol trinitrate reductase activity
HLB41_09570	COG0069	glutamate synthase activity
HLB41_09580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HLB41_09585	COG0346	lactoylglutathione lyase activity
HLB41_09590	COG0400	carboxylic ester hydrolase activity
HLB41_09595	COG5002	protein histidine kinase activity
HLB41_09605	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLB41_09640	COG1396	sequence-specific DNA binding
HLB41_09645	COG0318	PFAM AMP-dependent synthetase and ligase
HLB41_09650	COG1268	BioY protein
HLB41_09655	COG0318	PFAM AMP-dependent synthetase and ligase
HLB41_09660	COG0183	Belongs to the thiolase family
HLB41_09675	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HLB41_09685	COG2211	Major facilitator Superfamily
HLB41_09715	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HLB41_09720	COG1132	(ABC) transporter
HLB41_09735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLB41_09760	COG0824	Thioesterase
HLB41_09765	COG4841	protein insertion into membrane
HLB41_09785	COG0745	RESPONSE REGULATOR receiver
HLB41_09790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLB41_09795	COG1832	CoA-binding protein
HLB41_09800	COG0187	DNA topoisomerase II activity
HLB41_09805	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HLB41_09810	COG0673	inositol 2-dehydrogenase activity
HLB41_09845	COG1131	(ABC) transporter
HLB41_09855	COG1595	DNA-templated transcription, initiation
HLB41_09865	COG1316	TRANSCRIPTIONal
HLB41_09870	COG1301	dicarboxylic acid transport
HLB41_09875	COG4166	transmembrane transport
HLB41_09880	COG4166	transmembrane transport
HLB41_09885	COG4166	transmembrane transport
HLB41_09890	COG2226	methyltransferase
HLB41_09925	COG0531	amino acid
HLB41_09945	COG3383	formate dehydrogenase (NAD+) activity
HLB41_09950	COG2427	Protein of unknown function (DUF1641)
HLB41_09955	COG5609	conserved protein (DUF2294)
HLB41_09960	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HLB41_09970	COG2116	formate transmembrane transporter activity
HLB41_09975	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HLB41_09980	COG0303	'Molybdopterin
HLB41_09985	COG0314	molybdopterin synthase activity
HLB41_09995	COG0489	protein tyrosine kinase activity
HLB41_10010	COG3326	Membrane
HLB41_10015	COG2962	Rard protein
HLB41_10020	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HLB41_10025	COG1657	PFAM Prenyltransferase squalene oxidase
HLB41_10035	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_10040	COG1012	belongs to the aldehyde dehydrogenase family
HLB41_10050	COG4145	pantothenate transmembrane transporter activity
HLB41_10065	COG0165	Argininosuccinate lyase
HLB41_10075	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_10095	COG0494	nUDIX hydrolase
HLB41_10105	COG0716	FMN binding
HLB41_10140	COG2720	vancomycin resistance protein
HLB41_10145	COG2514	catechol 2,3-dioxygenase activity
HLB41_10155	COG1285	pathogenesis
HLB41_10195	COG0277	FAD linked oxidase domain protein
HLB41_10215	COG2808	Putative FMN-binding domain
HLB41_10225	COG0457	Tetratricopeptide repeat
HLB41_10235	COG0604	alcohol dehydrogenase
HLB41_10240	COG0640	Transcriptional regulator
HLB41_10255	COG0584	glycerophosphoryl diester phosphodiesterase
HLB41_10280	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HLB41_10295	COG3781	membrane
HLB41_10320	COG1164	Oligoendopeptidase f
HLB41_10325	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HLB41_10340	COG1193	negative regulation of DNA recombination
HLB41_10360	COG0583	DNA-binding transcription factor activity
HLB41_10390	COG3739	integral membrane protein
HLB41_10395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB41_10400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB41_10405	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLB41_10420	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HLB41_10425	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HLB41_10450	COG2814	Major facilitator Superfamily
HLB41_10455	COG1113	amino acid transport
HLB41_10490	COG2072	flavoprotein involved in K transport
HLB41_10515	COG1151	hydroxylamine reductase activity
HLB41_10595	COG1191	sigma factor activity
HLB41_10605	COG0726	polysaccharide deacetylase
HLB41_10620	COG1733	regulation of RNA biosynthetic process
HLB41_10625	COG2249	NAD(P)H dehydrogenase (quinone) activity
HLB41_10630	COG0318	PFAM AMP-dependent synthetase and ligase
HLB41_10635	COG0384	phenazine biosynthesis protein PhzF
HLB41_10655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB41_10675	COG1733	regulation of RNA biosynthetic process
HLB41_10680	COG1733	regulation of RNA biosynthetic process
HLB41_10685	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HLB41_10690	COG0673	inositol 2-dehydrogenase activity
HLB41_10695	COG2188	Transcriptional regulator
HLB41_10700	COG1733	regulation of RNA biosynthetic process
HLB41_10730	COG0814	amino acid
HLB41_10755	COG2814	Major facilitator Superfamily
HLB41_10760	COG0656	L-ascorbic acid biosynthetic process
HLB41_10775	COG1733	regulation of RNA biosynthetic process
HLB41_10780	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HLB41_10780	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HLB41_10785	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HLB41_10785	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HLB41_10795	COG0840	transmembrane signaling receptor activity
HLB41_10810	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_10820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLB41_10825	COG0604	alcohol dehydrogenase
HLB41_10835	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HLB41_10840	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HLB41_10845	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HLB41_10860	COG1070	Carbohydrate kinase
HLB41_10865	COG2706	6-phosphogluconolactonase activity
HLB41_10870	COG3813	Protein conserved in bacteria
HLB41_10875	COG1357	PFAM Pentapeptide repeats (8 copies)
HLB41_10885	COG0697	spore germination
HLB41_10890	COG0789	Transcriptional regulator
HLB41_10895	COG1253	flavin adenine dinucleotide binding
HLB41_10950	COG0628	permease
HLB41_10995	COG1011	Hydrolase
HLB41_11020	COG1131	(ABC) transporter
HLB41_11030	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_11060	COG0778	Nitroreductase
HLB41_11065	COG1733	regulation of RNA biosynthetic process
HLB41_11085	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HLB41_11105	COG2356	endonuclease I
HLB41_11110	COG1288	antiporter activity
HLB41_11165	COG2249	NAD(P)H dehydrogenase (quinone) activity
HLB41_11175	COG2031	fatty acid transporter
HLB41_11195	COG1131	(ABC) transporter
HLB41_11200	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HLB41_11210	COG2814	Major facilitator Superfamily
HLB41_11215	COG1846	Transcriptional regulator
HLB41_11230	COG0477	Major facilitator Superfamily
HLB41_11240	COG2843	Capsule synthesis protein
HLB41_11245	COG1876	peptidase activity
HLB41_11270	COG5444	nuclease activity
HLB41_11275	COG2849	repeat protein
HLB41_11505	COG3409	Peptidoglycan-binding domain 1 protein
HLB41_11505	COG5632	N-Acetylmuramoyl-L-alanine amidase
HLB41_11530	COG2207	Transcriptional regulator
HLB41_11530	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLB41_11535	COG0662	Cupin 2, conserved barrel domain protein
HLB41_11555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HLB41_11575	COG1619	proteins homologs of microcin C7 resistance protein MccF
HLB41_11600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLB41_11610	COG3850	Histidine kinase
HLB41_11610	COG5002	protein histidine kinase activity
HLB41_11630	COG0577	efflux transmembrane transporter activity
HLB41_11650	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HLB41_11665	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HLB41_11685	COG2814	Major facilitator Superfamily
HLB41_11735	COG5002	protein histidine kinase activity
HLB41_11735	COG3850	Histidine kinase
HLB41_11740	COG0745	RESPONSE REGULATOR receiver
HLB41_11800	COG1309	transcriptional regulator
HLB41_11850	COG0346	lactoylglutathione lyase activity
HLB41_11875	COG1522	sequence-specific DNA binding
HLB41_11880	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_11885	COG1309	transcriptional regulator
HLB41_11890	COG3320	Male sterility
HLB41_11890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HLB41_11895	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HLB41_11905	COG0640	Transcriptional regulator
HLB41_11910	COG0346	lactoylglutathione lyase activity
HLB41_11915	COG0798	PFAM Bile acid sodium symporter
HLB41_11930	COG4154	Belongs to the RbsD FucU family
HLB41_11940	COG1172	Belongs to the binding-protein-dependent transport system permease family
HLB41_11950	COG0235	Class ii aldolase
HLB41_11955	COG1070	Carbohydrate kinase
HLB41_11965	COG3347	Dehydrogenase
HLB41_11965	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_11975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLB41_12000	COG1575	Belongs to the MenA family. Type 1 subfamily
HLB41_12005	COG0456	acetyltransferase
HLB41_12015	COG0697	spore germination
HLB41_12030	COG5609	conserved protein (DUF2294)
HLB41_12035	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HLB41_12045	COG0288	reversible hydration of carbon dioxide
HLB41_12060	COG0415	Belongs to the DNA photolyase family
HLB41_12080	COG1073	alpha beta
HLB41_12100	COG0598	Magnesium transport protein CorA
HLB41_12105	COG1846	Transcriptional regulator
HLB41_12110	COG0583	DNA-binding transcription factor activity
HLB41_12130	COG1335	isochorismatase
HLB41_12135	COG2267	carboxylic ester hydrolase activity
HLB41_12140	COG0737	Belongs to the 5'-nucleotidase family
HLB41_12155	COG2124	cytochrome p450
HLB41_12165	COG1115	amino acid carrier protein
HLB41_12170	COG2066	Belongs to the glutaminase family
HLB41_12175	COG4191	Histidine kinase
HLB41_12185	COG0697	spore germination
HLB41_12190	COG0531	amino acid
HLB41_12205	COG0531	amino acid
HLB41_12210	COG0322	excinuclease ABC activity
HLB41_12225	COG2207	Transcriptional regulator
HLB41_12250	COG5002	protein histidine kinase activity
HLB41_12285	COG1396	sequence-specific DNA binding
HLB41_12290	COG0252	asparaginase activity
HLB41_12295	COG1027	Aspartate ammonia-lyase
HLB41_12305	COG1063	alcohol dehydrogenase
HLB41_12325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB41_12330	COG0574	Belongs to the PEP-utilizing enzyme family
HLB41_12330	COG3848	Pyruvate phosphate dikinase
HLB41_12390	COG1960	acyl-CoA dehydrogenase activity
HLB41_12400	COG0640	Transcriptional regulator
HLB41_12405	COG3142	Participates in the control of copper homeostasis
HLB41_12415	COG1414	Transcriptional regulator
HLB41_12420	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HLB41_12425	COG1984	allophanate hydrolase subunit 2
HLB41_12490	COG4335	DNA alkylation repair
HLB41_12500	COG0833	amino acid
HLB41_12510	COG0730	response to heat
HLB41_12555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLB41_12560	COG0697	spore germination
HLB41_12575	COG0456	acetyltransferase
HLB41_12605	COG1136	(ABC) transporter
HLB41_12620	COG4884	unkown
HLB41_12620	COG3831	ATPase activity
HLB41_12640	COG1846	Transcriptional regulator
HLB41_12645	COG0778	Nitroreductase
HLB41_12755	COG0714	Associated with various cellular activities
HLB41_12795	COG0753	catalase activity
HLB41_12800	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HLB41_12830	COG0463	Glycosyl transferase, family 2
HLB41_12855	COG0714	Associated with various cellular activities
HLB41_12880	COG0346	lactoylglutathione lyase activity
HLB41_12885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLB41_12905	COG3655	Transcriptional regulator
HLB41_12915	COG1785	Belongs to the alkaline phosphatase family
HLB41_12920	COG2720	vancomycin resistance protein
HLB41_12930	COG3239	Fatty acid desaturase
HLB41_12940	COG0833	amino acid
HLB41_12945	COG1414	Transcriptional regulator
HLB41_12950	COG4187	Peptidase family M20/M25/M40
HLB41_12955	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HLB41_12970	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HLB41_12990	COG2329	Antibiotic biosynthesis monooxygenase
HLB41_13010	COG1070	Carbohydrate kinase
HLB41_13015	COG2390	Transcriptional regulator
HLB41_13025	COG1172	Belongs to the binding-protein-dependent transport system permease family
HLB41_13030	COG1172	Belongs to the binding-protein-dependent transport system permease family
HLB41_13035	COG1879	ABC-type sugar transport system periplasmic component
HLB41_13050	COG1309	transcriptional regulator
HLB41_13065	COG0346	lactoylglutathione lyase activity
HLB41_13075	COG3584	3D domain protein
HLB41_13075	COG1388	LysM domain
HLB41_13115	COG1605	Chorismate mutase
HLB41_13115	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HLB41_13130	COG0287	Prephenate dehydrogenase
HLB41_13145	COG1309	transcriptional regulator
HLB41_13150	COG2409	Drug exporters of the RND superfamily
HLB41_13150	COG1033	growth of symbiont in host cell
HLB41_13155	COG0488	(ABC) transporter
HLB41_13160	COG1368	sulfuric ester hydrolase activity
HLB41_13165	COG0861	Integral membrane protein TerC family
HLB41_13180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB41_13185	COG0346	lactoylglutathione lyase activity
HLB41_13190	COG4912	Dna alkylation repair
HLB41_13210	COG2318	DinB family
HLB41_13215	COG0697	spore germination
HLB41_13225	COG2746	aminoglycoside 3-N-acetyltransferase activity
HLB41_13265	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLB41_13270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLB41_13275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLB41_13285	COG0628	permease
HLB41_13335	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HLB41_13340	COG0436	Aminotransferase
HLB41_13375	COG2226	methyltransferase
HLB41_13390	COG2261	transglycosylase associated protein
HLB41_13415	COG4533	DNA binding
HLB41_13420	COG0789	Transcriptional regulator
HLB41_13425	COG1664	Polymer-forming cytoskeletal
HLB41_13435	COG2814	Major facilitator Superfamily
HLB41_13475	COG1307	EDD domain protein, DegV family
HLB41_13480	COG1164	Oligoendopeptidase f
HLB41_13520	COG0745	RESPONSE REGULATOR receiver
HLB41_13525	COG3850	Histidine kinase
HLB41_13525	COG5002	protein histidine kinase activity
HLB41_13570	COG0667	Aldo Keto reductase
HLB41_13585	COG4948	Mandelate Racemase Muconate Lactonizing
HLB41_13595	COG4166	transmembrane transport
HLB41_13605	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HLB41_13615	COG0586	Pfam SNARE associated Golgi protein
HLB41_13620	COG1078	dGTPase activity
HLB41_13660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLB41_13665	COG3938	Belongs to the proline racemase family
HLB41_13675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLB41_13680	COG1012	belongs to the aldehyde dehydrogenase family
HLB41_13685	COG1115	amino acid carrier protein
HLB41_13690	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HLB41_13705	COG3397	chitin binding
HLB41_13720	COG4637	Psort location Cytoplasmic, score
HLB41_13755	COG0514	ATP-dependent DNA helicase (RecQ)
HLB41_13770	COG3973	AAA domain
HLB41_13815	COG2315	Protein conserved in bacteria
HLB41_13820	COG2226	methyltransferase
HLB41_13825	COG2205	protein histidine kinase activity
HLB41_13845	COG1819	glycosyl
HLB41_13850	COG3397	chitin binding
HLB41_13855	COG2153	protein acetylation
HLB41_13885	COG0517	IMP dehydrogenase activity
HLB41_13885	COG4175	Glycine betaine
HLB41_13890	COG4176	ABC-type proline glycine betaine transport system permease component
HLB41_13920	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_13935	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HLB41_13940	COG0022	dehydrogenase e1 component
HLB41_13945	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLB41_13950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLB41_13965	COG1959	2 iron, 2 sulfur cluster binding
HLB41_13980	COG1349	DNA-binding transcription factor activity
HLB41_13995	COG3284	Transcriptional regulator
HLB41_14020	COG1309	transcriptional regulator
HLB41_14060	COG2959	enzyme of heme biosynthesis
HLB41_14075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLB41_14105	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HLB41_14110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLB41_14115	COG0697	spore germination
HLB41_14120	COG0201	protein transport
HLB41_14140	COG0737	Belongs to the 5'-nucleotidase family
HLB41_14145	COG3227	Zinc metalloprotease (Elastase)
HLB41_14150	COG1523	belongs to the glycosyl hydrolase 13 family
HLB41_14155	COG1073	alpha beta
HLB41_14170	COG1011	Hydrolase
HLB41_14205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLB41_14225	COG1131	(ABC) transporter
HLB41_14255	COG0322	excinuclease ABC activity
HLB41_14295	COG4667	esterase of the alpha-beta hydrolase superfamily
HLB41_14315	COG3878	Protein conserved in bacteria
HLB41_14320	COG0251	oxidation-reduction process
HLB41_14340	COG0592	DNA-directed DNA polymerase activity
HLB41_14360	COG2223	nitrite transmembrane transporter activity
HLB41_14405	COG0697	spore germination
HLB41_14410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLB41_14430	COG0584	glycerophosphoryl diester phosphodiesterase
HLB41_14445	COG2814	Major facilitator Superfamily
HLB41_14500	COG0671	phosphoesterase, PA-phosphatase related
HLB41_14505	COG0604	alcohol dehydrogenase
HLB41_14570	COG2205	protein histidine kinase activity
HLB41_14595	COG1794	racemase activity, acting on amino acids and derivatives
HLB41_14600	COG1819	glycosyl
HLB41_14615	COG5002	protein histidine kinase activity
HLB41_14620	COG0561	phosphatase activity
HLB41_14645	COG2124	cytochrome p450
HLB41_14665	COG2124	cytochrome p450
HLB41_14720	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HLB41_14730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLB41_14735	COG0460	homoserine dehydrogenase
HLB41_14755	COG0577	efflux transmembrane transporter activity
HLB41_14760	COG1136	(ABC) transporter
HLB41_14780	COG2205	protein histidine kinase activity
HLB41_14785	COG0745	RESPONSE REGULATOR receiver
HLB41_14795	COG3773	Cell wall hydrolase
HLB41_14800	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HLB41_14810	COG3386	PFAM SMP-30 Gluconolaconase
HLB41_14820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HLB41_14825	COG2323	membrane
HLB41_14835	COG1063	alcohol dehydrogenase
HLB41_14860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLB41_14910	COG1733	regulation of RNA biosynthetic process
HLB41_14915	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_14920	COG2814	Major facilitator Superfamily
HLB41_14930	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HLB41_14960	COG2207	Transcriptional regulator
HLB41_14965	COG3227	Zinc metalloprotease (Elastase)
HLB41_14980	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HLB41_15005	COG1686	Belongs to the peptidase S11 family
HLB41_15040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLB41_15045	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HLB41_15050	COG1024	Enoyl-CoA hydratase
HLB41_15055	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HLB41_15060	COG0511	ligase activity, forming carbon-carbon bonds
HLB41_15065	COG0439	Biotin carboxylase
HLB41_15070	COG1960	acyl-CoA dehydrogenase activity
HLB41_15085	COG1309	transcriptional regulator
HLB41_15095	COG1131	(ABC) transporter
HLB41_15105	COG1408	metallophosphoesterase
HLB41_15120	COG0768	penicillin binding
HLB41_15130	COG1595	DNA-templated transcription, initiation
HLB41_15135	COG0768	penicillin binding
HLB41_15140	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HLB41_15175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLB41_15180	COG0741	lytic transglycosylase activity
HLB41_15185	COG2312	Erythromycin esterase
HLB41_15220	COG2814	Major facilitator Superfamily
HLB41_15235	COG1686	Belongs to the peptidase S11 family
HLB41_15240	COG0110	maltose O-acetyltransferase activity
HLB41_15245	COG0730	response to heat
HLB41_15255	COG2002	toxin-antitoxin pair type II binding
HLB41_15280	COG2195	Cleaves the N-terminal amino acid of tripeptides
HLB41_15310	COG1846	Transcriptional regulator
HLB41_15315	COG3961	Belongs to the TPP enzyme family
HLB41_15330	COG0500	methyltransferase
HLB41_15330	COG3615	Tellurite resistance protein tehB
HLB41_15350	COG1309	transcriptional regulator
HLB41_15370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB41_15390	COG1846	Transcriptional regulator
HLB41_15400	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HLB41_15410	COG2971	BadF BadG BcrA BcrD
HLB41_15435	COG1649	PFAM Uncharacterised BCR, COG1649
HLB41_15465	COG1595	DNA-templated transcription, initiation
HLB41_15470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLB41_15500	COG1396	sequence-specific DNA binding
HLB41_15525	COG1132	(ABC) transporter
HLB41_15530	COG1132	(ABC) transporter
HLB41_15545	COG2258	MOSC domain
HLB41_15550	COG0583	DNA-binding transcription factor activity
HLB41_15570	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HLB41_15575	COG0583	DNA-binding transcription factor activity
HLB41_15605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLB41_15640	COG1247	-acetyltransferase
HLB41_15670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB41_15690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLB41_15730	COG1136	(ABC) transporter
HLB41_15735	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HLB41_15740	COG1187	pseudouridine synthase activity
HLB41_15760	COG1115	amino acid carrier protein
HLB41_15770	COG2318	DinB family
HLB41_15780	COG0776	regulation of translation
HLB41_15795	COG2814	Major facilitator Superfamily
HLB41_15800	COG3251	PFAM MbtH domain protein
HLB41_15805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HLB41_15810	COG1535	isochorismatase
HLB41_15810	COG3433	isochorismatase activity
HLB41_15815	COG1021	2,3-dihydroxybenzoate-AMP ligase
HLB41_15820	COG1169	isochorismate synthase
HLB41_15825	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_15830	COG2223	nitrite transmembrane transporter activity
HLB41_15855	COG0419	ATPase involved in DNA repair
HLB41_15860	COG0420	3'-5' exonuclease activity
HLB41_15875	COG1024	Enoyl-CoA hydratase
HLB41_15880	COG1280	lysine exporter protein (LysE YggA)
HLB41_15890	COG2084	Dehydrogenase
HLB41_15895	COG1960	acyl-CoA dehydrogenase activity
HLB41_15900	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HLB41_15905	COG2079	MmgE PrpD family protein
HLB41_15910	COG0372	Belongs to the citrate synthase family
HLB41_15915	COG4841	protein insertion into membrane
HLB41_15920	COG2814	Major facilitator Superfamily
HLB41_15930	COG4499	WXG100 protein secretion system (Wss), protein YukC
HLB41_15930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLB41_15950	COG0300	oxidoreductase activity
HLB41_16040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLB41_16045	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HLB41_16050	COG0671	phosphoesterase, PA-phosphatase related
HLB41_16060	COG4991	sh3 domain protein
HLB41_16060	COG3064	Membrane
HLB41_16060	COG0515	serine threonine protein kinase
HLB41_16095	COG1509	lysine 2,3-aminomutase activity
HLB41_16100	COG3829	transcription factor binding
HLB41_16105	COG0456	acetyltransferase
HLB41_16110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLB41_16115	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HLB41_16120	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HLB41_16125	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HLB41_16140	COG5506	Protein of unknown function (DUF1694)
HLB41_16145	COG1012	belongs to the aldehyde dehydrogenase family
HLB41_16150	COG1253	flavin adenine dinucleotide binding
HLB41_16185	COG1174	glycine betaine transport
HLB41_16190	COG1125	glycine betaine transport
HLB41_16190	COG0517	IMP dehydrogenase activity
HLB41_16220	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HLB41_16245	COG1064	alcohol dehydrogenase
HLB41_16250	COG0384	phenazine biosynthesis protein PhzF
HLB41_16255	COG1737	Transcriptional regulator
HLB41_16260	COG2197	response regulator
HLB41_16265	COG4585	Histidine kinase
HLB41_16265	COG2203	Gaf domain
HLB41_16270	COG0668	transmembrane transport
HLB41_16280	COG1335	isochorismatase
HLB41_16300	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HLB41_16305	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLB41_16310	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLB41_16325	COG0367	asparagine synthase
HLB41_16330	COG0071	Belongs to the small heat shock protein (HSP20) family
HLB41_16335	COG1999	signal sequence binding
HLB41_16345	COG1307	EDD domain protein, DegV family
HLB41_16355	COG0805	protein transport
HLB41_16365	COG1272	protein, Hemolysin III
HLB41_16370	COG0204	Acyl-transferase
HLB41_16380	COG0768	penicillin binding
HLB41_16395	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HLB41_16410	COG0546	phosphoglycolate phosphatase activity
HLB41_16420	COG4473	ABC transporter
HLB41_16425	COG1131	(ABC) transporter
HLB41_16435	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HLB41_16440	COG3655	Transcriptional regulator
HLB41_16450	COG0456	acetyltransferase
HLB41_16460	COG1794	racemase activity, acting on amino acids and derivatives
HLB41_16470	COG2610	gluconate transmembrane transporter activity
HLB41_16495	COG0733	neurotransmitter:sodium symporter activity
HLB41_16510	COG5002	protein histidine kinase activity
HLB41_16510	COG3850	Histidine kinase
HLB41_16515	COG0745	RESPONSE REGULATOR receiver
HLB41_16525	COG1929	Belongs to the glycerate kinase type-1 family
HLB41_16530	COG0017	Asparaginyl-tRNA synthetase
HLB41_16570	COG0018	arginyl-trna synthetase
HLB41_16575	COG2136	Putative SAM-dependent methyltransferase
HLB41_16575	COG2521	methyltransferase
HLB41_16590	COG1413	lyase activity
HLB41_16595	COG0629	single-stranded DNA binding
HLB41_16610	COG0488	(ABC) transporter
HLB41_16615	COG1418	mRNA catabolic process
HLB41_16630	COG0457	Tetratricopeptide repeat
HLB41_16655	COG4974	Belongs to the 'phage' integrase family
HLB41_16685	COG2359	stage V sporulation protein S
HLB41_16720	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HLB41_16725	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLB41_16730	COG2146	nitrite reductase [NAD(P)H] activity
HLB41_16735	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HLB41_16735	COG1587	Uroporphyrinogen-III synthase
HLB41_16745	COG1648	precorrin-2 dehydrogenase activity
HLB41_16765	COG2223	nitrite transmembrane transporter activity
HLB41_16775	COG0314	molybdopterin synthase activity
HLB41_16780	COG0303	'Molybdopterin
HLB41_16785	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HLB41_16790	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HLB41_16795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLB41_16800	COG2181	nitrate reductase activity
HLB41_16805	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HLB41_16810	COG1140	nitrate reductase beta subunit
HLB41_16815	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HLB41_16820	COG0714	Associated with various cellular activities
HLB41_16825	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HLB41_16830	COG1305	Transglutaminase-like
HLB41_16835	COG0386	Belongs to the glutathione peroxidase family
HLB41_16845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLB41_16845	COG0426	domain, Protein
HLB41_16855	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HLB41_16865	COG1595	DNA-templated transcription, initiation
HLB41_16870	COG0604	alcohol dehydrogenase
HLB41_16880	COG0346	lactoylglutathione lyase activity
HLB41_16905	COG2226	methyltransferase
HLB41_16930	COG3874	Sporulation protein YtfJ
HLB41_17055	COG4499	WXG100 protein secretion system (Wss), protein YukC
HLB41_17090	COG0456	acetyltransferase
HLB41_17120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLB41_17125	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLB41_17130	COG1819	glycosyl
HLB41_17145	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HLB41_17160	COG0561	phosphatase activity
HLB41_17170	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLB41_17185	COG2211	Major facilitator Superfamily
HLB41_17190	COG0154	amidase activity
HLB41_17200	COG1876	peptidase activity
HLB41_17210	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLB41_17230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLB41_17235	COG1114	Component of the transport system for branched-chain amino acids
HLB41_17250	COG1253	flavin adenine dinucleotide binding
HLB41_17255	COG2839	Protein conserved in bacteria
HLB41_17260	COG0702	epimerase
HLB41_17275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLB41_17285	COG1607	acyl-coa hydrolase
HLB41_17290	COG3689	TIGRFAM TIGR03943 family protein
HLB41_17295	COG0701	Predicted permease
HLB41_17305	COG2244	polysaccharide biosynthetic process
HLB41_17310	COG0586	Pfam SNARE associated Golgi protein
HLB41_17315	COG1051	belongs to the nudix hydrolase family
HLB41_17320	COG5337	Spore coat protein CotH
HLB41_17345	COG4166	transmembrane transport
HLB41_17355	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HLB41_17365	COG0702	epimerase
HLB41_17375	COG0803	Belongs to the bacterial solute-binding protein 9 family
HLB41_17380	COG0456	acetyltransferase
HLB41_17385	COG0523	cobalamin synthesis protein
HLB41_17390	COG4989	oxidoreductase activity
HLB41_17395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLB41_17400	COG1231	oxidoreductase activity
HLB41_17410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLB41_17425	COG0783	Belongs to the Dps family
HLB41_17430	COG3949	Membrane
HLB41_17445	COG0840	transmembrane signaling receptor activity
HLB41_17470	COG3152	Membrane
HLB41_17480	COG2814	Major facilitator Superfamily
HLB41_17485	COG0667	Aldo Keto reductase
HLB41_17490	COG0640	Transcriptional regulator
HLB41_17495	COG1404	Belongs to the peptidase S8 family
HLB41_17500	COG2002	toxin-antitoxin pair type II binding
HLB41_17505	COG0577	efflux transmembrane transporter activity
HLB41_17540	COG1752	Esterase of the alpha-beta hydrolase superfamily
HLB41_17550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLB41_17555	COG1279	arginine transmembrane transporter activity
HLB41_17560	COG2814	Major facilitator Superfamily
HLB41_17570	COG1082	Xylose isomerase domain protein TIM barrel
HLB41_17585	COG0318	PFAM AMP-dependent synthetase and ligase
HLB41_17590	COG4264	IucA IucC family
HLB41_17600	COG1247	-acetyltransferase
HLB41_17605	COG1285	pathogenesis
HLB41_17620	COG5002	protein histidine kinase activity
HLB41_17625	COG0745	RESPONSE REGULATOR receiver
HLB41_17635	COG1316	TRANSCRIPTIONal
HLB41_17660	COG0460	homoserine dehydrogenase
HLB41_17690	COG0300	oxidoreductase activity
HLB41_17700	COG5002	protein histidine kinase activity
HLB41_17705	COG0745	RESPONSE REGULATOR receiver
HLB41_17710	COG1132	(ABC) transporter
HLB41_17720	COG1388	LysM domain
HLB41_17720	COG0791	NLP P60 protein
HLB41_17735	COG1686	Belongs to the peptidase S11 family
HLB41_17775	COG1216	Glycosyl transferase, family 2
HLB41_17785	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HLB41_17790	COG4988	ABC transporter
HLB41_17795	COG1294	oxidase, subunit
HLB41_17800	COG1271	oxidase subunit
HLB41_17830	COG0583	DNA-binding transcription factor activity
HLB41_17850	COG0411	ABC transporter
HLB41_17860	COG0523	cobalamin synthesis protein
HLB41_17865	COG1231	oxidoreductase activity
HLB41_17875	COG0628	permease
HLB41_17885	COG0778	Nitroreductase
HLB41_17890	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HLB41_17895	COG1959	2 iron, 2 sulfur cluster binding
HLB41_17900	COG0583	DNA-binding transcription factor activity
HLB41_17905	COG0697	spore germination
HLB41_17910	COG4549	nuclear export factor GLE1
HLB41_17915	COG2372	response to copper ion
HLB41_17915	COG1276	copper resistance
HLB41_17925	COG1114	Component of the transport system for branched-chain amino acids
HLB41_17955	COG2132	Multicopper oxidase
HLB41_17965	COG0006	proline dipeptidase activity
HLB41_17975	COG4846	Membrane protein involved in cytochrome C biogenesis
HLB41_17985	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HLB41_17990	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HLB41_18000	COG2390	Transcriptional regulator
HLB41_18005	COG1309	transcriptional regulator
HLB41_18020	COG0456	acetyltransferase
HLB41_18035	COG2309	aminopeptidase activity
HLB41_18065	COG0531	amino acid
HLB41_18070	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HLB41_18085	COG1914	H( )-stimulated, divalent metal cation uptake system
HLB41_18105	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLB41_18130	COG4166	transmembrane transport
HLB41_18150	COG0427	acetyl-CoA hydrolase
HLB41_18155	COG3279	Response regulator of the LytR AlgR family
HLB41_18165	COG3384	dioxygenase
HLB41_18170	COG2814	Major facilitator Superfamily
HLB41_18195	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HLB41_18215	COG0028	Belongs to the TPP enzyme family
HLB41_18220	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HLB41_18230	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HLB41_18250	COG2323	membrane
HLB41_18255	COG5566	PFAM Mor transcription activator
HLB41_18265	COG0733	neurotransmitter:sodium symporter activity
HLB41_18285	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HLB41_18290	COG2223	nitrite transmembrane transporter activity
HLB41_18295	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HLB41_18310	COG0477	Major facilitator Superfamily
HLB41_18320	COG1695	Transcriptional regulator
HLB41_18335	COG2814	Major facilitator Superfamily
HLB41_18380	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HLB41_18385	COG0784	Response regulator, receiver
HLB41_18390	COG4191	Histidine kinase
HLB41_18395	COG0281	malic enzyme
HLB41_18400	COG1027	Aspartate ammonia-lyase
HLB41_18415	COG0528	UMP kinase activity
HLB41_18420	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLB41_18435	COG1131	(ABC) transporter
HLB41_18470	COG2733	membrane
HLB41_18490	COG0457	Tetratricopeptide repeat
HLB41_18505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLB41_18510	COG0785	Cytochrome C biogenesis protein
HLB41_18530	COG3340	Belongs to the peptidase S51 family
HLB41_18535	COG0534	Mate efflux family protein
HLB41_18560	COG0789	Transcriptional regulator
HLB41_18565	COG1757	Na H antiporter
HLB41_18580	COG0701	Predicted permease
HLB41_18585	COG0523	cobalamin synthesis protein
HLB41_18595	COG0697	spore germination
HLB41_18600	COG1802	Transcriptional regulator
HLB41_18630	COG0367	asparagine synthase
HLB41_18660	COG0406	alpha-ribazole phosphatase activity
HLB41_18700	COG0725	ABC transporter, periplasmic molybdate-binding protein
HLB41_18710	COG0583	DNA-binding transcription factor activity
HLB41_18735	COG2329	Antibiotic biosynthesis monooxygenase
HLB41_18770	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HLB41_18775	COG4786	Flagellar basal body rod
HLB41_18780	COG1419	protein localization to endoplasmic reticulum
HLB41_18785	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HLB41_18790	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HLB41_18800	COG1987	bacterial-type flagellum assembly
HLB41_18805	COG1338	Plays a role in the flagellum-specific transport system
HLB41_18815	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HLB41_18815	COG1776	CheC inhibitor of MCP methylation
HLB41_18820	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HLB41_18830	COG0741	lytic transglycosylase activity
HLB41_18840	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HLB41_18850	COG0784	Response regulator, receiver
HLB41_18850	COG0835	chemotaxis
HLB41_18865	COG1749	Flagellar hook protein flgE
HLB41_18885	COG1157	protein secretion by the type III secretion system
HLB41_18895	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HLB41_18900	COG1766	The M ring may be actively involved in energy transduction
HLB41_18910	COG1558	bacterial-type flagellum-dependent cell motility
HLB41_18915	COG1815	bacterial-type flagellum-dependent cell motility
HLB41_18935	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HLB41_18940	COG1256	bacterial-type flagellum assembly
HLB41_18960	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HLB41_18975	COG1776	CheC inhibitor of MCP methylation
HLB41_18975	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HLB41_18980	COG2198	Histidine kinase
HLB41_18980	COG0643	Histidine kinase
HLB41_18985	COG2201	protein-glutamate methylesterase activity
HLB41_18990	COG1360	Flagellar Motor Protein
HLB41_18995	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HLB41_19005	COG1923	regulation of RNA biosynthetic process
HLB41_19040	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HLB41_19045	COG2323	membrane
HLB41_19055	COG0789	Transcriptional regulator
HLB41_19055	COG4978	Transcriptional regulator
HLB41_19060	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HLB41_19065	COG0475	glutathione-regulated potassium exporter activity
HLB41_19075	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HLB41_19080	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HLB41_19100	COG1280	lysine exporter protein (LysE YggA)
HLB41_19105	COG3403	YqcI/YcgG family
HLB41_19140	COG0328	RNA-DNA hybrid ribonuclease activity
HLB41_19160	COG0454	-acetyltransferase
HLB41_19175	COG0438	transferase activity, transferring glycosyl groups
HLB41_19180	COG1215	transferase activity, transferring glycosyl groups
HLB41_19195	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HLB41_19205	COG3944	biosynthesis protein
HLB41_19220	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HLB41_19270	COG0456	acetyltransferase
HLB41_19280	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HLB41_19285	COG2311	Membrane
HLB41_19290	COG2233	PERMEase
HLB41_19305	COG0024	Methionine aminopeptidase
HLB41_19315	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HLB41_19320	COG1199	ATP-dependent helicase activity
HLB41_19330	COG0116	Belongs to the methyltransferase superfamily
HLB41_19385	COG4499	WXG100 protein secretion system (Wss), protein YukC
HLB41_19385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLB41_19395	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HLB41_19400	COG3935	DnaD domain protein
HLB41_19420	COG1199	ATP-dependent helicase activity
HLB41_19420	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HLB41_19455	COG0438	transferase activity, transferring glycosyl groups
HLB41_19475	COG1694	Mazg nucleotide pyrophosphohydrolase
HLB41_19480	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLB41_19490	COG2738	Putative neutral zinc metallopeptidase
HLB41_19505	COG4347	Protein of unknown function (DUF1405)
HLB41_19510	COG2010	Cytochrome c
HLB41_19510	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HLB41_19515	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HLB41_19535	COG0457	Tetratricopeptide repeat
HLB41_19560	COG0142	geranyltranstransferase activity
HLB41_19570	COG0142	geranyltranstransferase activity
HLB41_19585	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HLB41_19655	COG0252	asparaginase activity
HLB41_19660	COG0492	ferredoxin-NADP+ reductase activity
HLB41_19680	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HLB41_19690	COG0789	Transcriptional regulator
HLB41_19695	COG1408	metallophosphoesterase
HLB41_19705	COG1266	CAAX protease self-immunity
HLB41_19710	COG0514	ATP-dependent DNA helicase (RecQ)
HLB41_19720	COG1141	Ferredoxin
HLB41_19725	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HLB41_19740	COG2096	Adenosyltransferase
HLB41_19745	COG5002	protein histidine kinase activity
HLB41_19750	COG0745	RESPONSE REGULATOR receiver
HLB41_19755	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HLB41_19760	COG1333	cytochrome c biogenesis protein
HLB41_19770	COG1187	pseudouridine synthase activity
HLB41_19775	COG0700	Nucleoside recognition
HLB41_19780	COG2715	membrane protein required for spore maturation
HLB41_19785	COG1686	Belongs to the peptidase S11 family
HLB41_19790	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HLB41_19805	COG0392	lysyltransferase activity
HLB41_19805	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HLB41_19820	COG5002	protein histidine kinase activity
HLB41_19825	COG0582	viral genome integration into host DNA
HLB41_19835	COG1801	Protein of unknown function DUF72
HLB41_19840	COG3852	Histidine kinase
HLB41_19855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLB41_19860	COG1392	Phosphate transport regulator
HLB41_19865	COG0306	phosphate transporter
HLB41_19870	COG0730	response to heat
HLB41_19920	COG1114	Component of the transport system for branched-chain amino acids
HLB41_19930	COG2197	response regulator
HLB41_19935	COG4585	Histidine kinase
HLB41_19940	COG4758	membrane
HLB41_19955	COG1757	Na H antiporter
HLB41_19980	COG0733	neurotransmitter:sodium symporter activity
HLB41_19985	COG1648	precorrin-2 dehydrogenase activity
HLB41_20005	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLB41_20010	COG0529	Catalyzes the synthesis of activated sulfate
HLB41_20030	COG0019	diaminopimelate decarboxylase activity
HLB41_20040	COG1368	sulfuric ester hydrolase activity
HLB41_20045	COG1183	phosphatidylcholine synthase activity
HLB41_20060	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HLB41_20135	COG0440	acetolactate synthase activity
HLB41_20140	COG0028	Belongs to the TPP enzyme family
HLB41_20145	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HLB41_20165	COG3874	Sporulation protein YtfJ
HLB41_20170	COG4709	membrane
HLB41_20175	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLB41_20180	COG1301	dicarboxylic acid transport
HLB41_20190	COG1846	Transcriptional regulator
HLB41_20230	COG3173	Aminoglycoside phosphotransferase
HLB41_20245	COG0716	FMN binding
HLB41_20265	COG1696	Membrane protein involved in D-alanine export
HLB41_20275	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HLB41_20280	COG2070	2-Nitropropane dioxygenase
HLB41_20285	COG1619	proteins homologs of microcin C7 resistance protein MccF
HLB41_20295	COG1335	isochorismatase
HLB41_20305	COG1522	sequence-specific DNA binding
HLB41_20325	COG1131	(ABC) transporter
HLB41_20335	COG1131	(ABC) transporter
HLB41_20340	COG1725	Transcriptional regulator
HLB41_20345	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLB41_20350	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLB41_20355	COG1780	Probably involved in ribonucleotide reductase function
HLB41_20380	COG4873	Protein conserved in bacteria
HLB41_20395	COG0720	synthase
HLB41_20405	COG5002	protein histidine kinase activity
HLB41_20410	COG2318	DinB family
HLB41_20420	COG1846	Transcriptional regulator
HLB41_20425	COG3852	Histidine kinase
HLB41_20435	COG2861	carbohydrate metabolic process
HLB41_20445	COG0235	Class ii aldolase
HLB41_20455	COG1349	DNA-binding transcription factor activity
HLB41_20480	COG3842	ATPase activity
HLB41_20485	COG1840	ABC-type Fe3 transport system, periplasmic component
HLB41_20500	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLB41_20510	COG3243	poly(R)-hydroxyalkanoic acid synthase
HLB41_20515	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_20535	COG2030	dehydratase
HLB41_20545	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLB41_20550	COG0861	Integral membrane protein TerC family
HLB41_20555	COG2116	formate transmembrane transporter activity
HLB41_20565	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HLB41_20585	COG2186	Transcriptional regulator
HLB41_20590	COG5002	protein histidine kinase activity
HLB41_20595	COG0745	RESPONSE REGULATOR receiver
HLB41_20605	COG3835	regulator
HLB41_20610	COG0277	FAD linked oxidase domain protein
HLB41_20615	COG0247	lactate metabolic process
HLB41_20620	COG2340	Cysteine-rich secretory protein family
HLB41_20630	COG0564	pseudouridine synthase activity
HLB41_20640	COG2409	Drug exporters of the RND superfamily
HLB41_20655	COG1177	transmembrane transport
HLB41_20660	COG1176	ABC-type spermidine putrescine transport system, permease component I
HLB41_20670	COG1012	belongs to the aldehyde dehydrogenase family
HLB41_20705	COG0681	Belongs to the peptidase S26 family
HLB41_20710	COG1686	Belongs to the peptidase S11 family
HLB41_20740	COG1668	transmembrane transport
HLB41_20745	COG4152	abc transporter atp-binding protein
HLB41_20760	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HLB41_20810	COG1476	TRANSCRIPTIONal
HLB41_20820	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLB41_20870	COG5634	Uncharacterized conserved protein (DUF2278)
HLB41_20875	COG1620	l-lactate permease
HLB41_20910	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HLB41_20910	COG0512	Glutamine amidotransferase of anthranilate synthase
HLB41_20920	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HLB41_20940	COG2382	esterase
HLB41_20950	COG2153	protein acetylation
HLB41_20995	COG1091	dTDP-4-dehydrorhamnose reductase activity
HLB41_21010	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HLB41_21030	COG0463	Glycosyl transferase, family 2
HLB41_21030	COG0457	Tetratricopeptide repeat
HLB41_21050	COG1216	Glycosyl transferase, family 2
HLB41_21055	COG0772	Belongs to the SEDS family
HLB41_21070	COG0564	pseudouridine synthase activity
HLB41_21080	COG2357	RelA SpoT domain protein
HLB41_21090	COG4116	CYTH
HLB41_21095	COG2346	COG2346, Truncated hemoglobins
HLB41_21110	COG1164	Oligoendopeptidase f
HLB41_21130	COG0861	Integral membrane protein TerC family
HLB41_21145	COG4166	transmembrane transport
HLB41_21150	COG0534	Mate efflux family protein
HLB41_21155	COG4608	Belongs to the ABC transporter superfamily
HLB41_21160	COG0444	Belongs to the ABC transporter superfamily
HLB41_21165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLB41_21170	COG0601	transmembrane transport
HLB41_21175	COG4166	transmembrane transport
HLB41_21185	COG0180	Tryptophanyl-tRNA synthetase
HLB41_21195	COG5504	Zn-dependent protease
HLB41_21200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HLB41_21220	COG2267	carboxylic ester hydrolase activity
HLB41_21240	COG0561	phosphatase activity
HLB41_21255	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLB41_21325	COG2996	Protein conserved in bacteria
HLB41_21345	COG0004	ammonium transporteR
HLB41_21350	COG0753	catalase activity
HLB41_21360	COG0367	asparagine synthase
HLB41_21385	COG0179	Fumarylacetoacetate (FAA) hydrolase
HLB41_21445	COG0398	Pfam SNARE associated Golgi protein
HLB41_21485	COG2224	Isocitrate lyase
HLB41_21490	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HLB41_21500	COG3693	PFAM glycoside hydrolase, family 10
HLB41_21505	COG0840	transmembrane signaling receptor activity
HLB41_21510	COG0501	Belongs to the peptidase M48B family
HLB41_21530	COG0745	RESPONSE REGULATOR receiver
HLB41_21535	COG2205	protein histidine kinase activity
HLB41_21540	COG2207	Transcriptional regulator
HLB41_21540	COG3708	Transcriptional regulator
HLB41_21545	COG1595	DNA-templated transcription, initiation
HLB41_21555	COG1078	dGTPase activity
HLB41_21560	COG1408	metallophosphoesterase
HLB41_21565	COG1073	alpha beta
HLB41_21725	COG4208	sulfate ABC transporter
HLB41_21735	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HLB41_21745	COG0318	PFAM AMP-dependent synthetase and ligase
HLB41_21755	COG0095	Lipoate-protein ligase
HLB41_21760	COG1234	tRNA 3'-trailer cleavage
HLB41_21770	COG1609	Transcriptional regulator
HLB41_21775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLB41_21795	COG1511	domain protein
HLB41_21800	COG1309	transcriptional regulator
HLB41_21850	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLB41_21855	COG2329	Antibiotic biosynthesis monooxygenase
HLB41_21860	COG3428	Bacterial PH domain
HLB41_21865	COG3402	PFAM membrane-flanked domain
HLB41_21870	COG0697	spore germination
HLB41_21900	COG3428	Bacterial PH domain
HLB41_21905	COG3402	PFAM membrane-flanked domain
HLB41_21930	COG4473	ABC transporter
HLB41_21935	COG1131	(ABC) transporter
HLB41_21940	COG0537	adenosine 5'-monophosphoramidase activity
HLB41_21945	COG4980	gas vesicle protein
HLB41_21965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLB41_21975	COG3973	AAA domain
HLB41_21990	COG1595	DNA-templated transcription, initiation
HLB41_22005	COG1695	Transcriptional regulator
HLB41_22010	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HLB41_22020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HLB41_22025	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HLB41_22030	COG3620	sequence-specific DNA binding
HLB41_22035	COG2140	Oxalate decarboxylase
HLB41_22060	COG2267	carboxylic ester hydrolase activity
HLB41_22070	COG0457	Tetratricopeptide repeat
HLB41_22075	COG0346	lactoylglutathione lyase activity
HLB41_22080	COG0346	lactoylglutathione lyase activity
HLB41_22090	COG4717	serine-type aminopeptidase activity
HLB41_22095	COG0420	3'-5' exonuclease activity
HLB41_22115	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HLB41_22160	COG5002	protein histidine kinase activity
HLB41_22160	COG2205	protein histidine kinase activity
HLB41_22160	COG0784	Response regulator, receiver
HLB41_22165	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HLB41_22170	COG2208	phosphoserine phosphatase activity
HLB41_22180	COG1191	sigma factor activity
HLB41_22250	COG0596	Alpha beta hydrolase
HLB41_22270	COG2373	Large extracellular alpha-helical protein
HLB41_22280	COG0791	NLP P60 protein
HLB41_22280	COG1388	LysM domain
HLB41_22285	COG1388	LysM domain
HLB41_22285	COG3584	3D domain protein
HLB41_22325	COG2376	Dihydroxyacetone kinase
HLB41_22335	COG2376	Dihydroxyacetone kinase
HLB41_22350	COG1183	phosphatidylcholine synthase activity
HLB41_22390	COG1073	alpha beta
HLB41_22410	COG3344	reverse transcriptase
HLB41_22415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLB41_22430	COG0477	Major facilitator Superfamily
HLB41_22455	COG0305	Participates in initiation and elongation during chromosome replication
HLB41_22490	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HLB41_22505	COG0494	nUDIX hydrolase
HLB41_22510	COG3181	Tripartite tricarboxylate transporter family receptor
HLB41_22515	COG4565	transcriptional regulatory protein
HLB41_22520	COG3290	protein histidine kinase activity
HLB41_22525	COG0477	Major facilitator Superfamily
HLB41_22755	COG0457	Tetratricopeptide repeat
HLB41_22775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB41_22785	COG4608	Belongs to the ABC transporter superfamily
HLB41_22790	COG0444	Belongs to the ABC transporter superfamily
HLB41_22795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLB41_22800	COG0601	transmembrane transport
HLB41_22835	COG1363	Peptidase, m42
HLB41_22855	COG1024	Enoyl-CoA hydratase
HLB41_22875	COG2244	polysaccharide biosynthetic process
HLB41_22880	COG0659	secondary active sulfate transmembrane transporter activity
HLB41_22895	COG0318	PFAM AMP-dependent synthetase and ligase
HLB41_22900	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HLB41_22905	COG5632	N-Acetylmuramoyl-L-alanine amidase
HLB41_22905	COG3409	Peptidoglycan-binding domain 1 protein
HLB41_22915	COG0561	phosphatase activity
HLB41_22925	COG3527	Alpha-acetolactate decarboxylase
HLB41_22930	COG0028	Belongs to the TPP enzyme family
HLB41_22935	COG2197	response regulator
HLB41_22940	COG4585	Histidine kinase
HLB41_22960	COG0189	ligase activity
HLB41_22975	COG1126	abc transporter atp-binding protein
HLB41_22980	COG0765	amino acid transport
HLB41_22985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB41_22990	COG1132	(ABC) transporter
HLB41_22995	COG1132	(ABC) transporter
HLB41_23000	COG1012	belongs to the aldehyde dehydrogenase family
HLB41_23010	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HLB41_23015	COG0531	amino acid
HLB41_23025	COG0693	protein deglycase activity
HLB41_23025	COG0753	catalase activity
HLB41_23030	COG0693	protein deglycase activity
HLB41_23045	COG2211	Major facilitator Superfamily
HLB41_23050	COG4533	DNA binding
HLB41_23055	COG2249	NAD(P)H dehydrogenase (quinone) activity
HLB41_23065	COG1733	regulation of RNA biosynthetic process
HLB41_23070	COG2814	Major facilitator Superfamily
HLB41_23075	COG1309	transcriptional regulator
HLB41_23095	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_23100	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HLB41_23100	COG0165	Argininosuccinate lyase
HLB41_23105	COG1522	sequence-specific DNA binding
HLB41_23125	COG2259	Doxx family
HLB41_23135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLB41_23135	COG1263	PTS System
HLB41_23145	COG1737	Transcriptional regulator
HLB41_23155	COG0475	glutathione-regulated potassium exporter activity
HLB41_23160	COG0531	amino acid
HLB41_23195	COG0586	Pfam SNARE associated Golgi protein
HLB41_23230	COG3546	catalase activity
HLB41_23235	COG1114	Component of the transport system for branched-chain amino acids
HLB41_23250	COG5522	Integral membrane protein (intg_mem_TP0381)
HLB41_23260	COG1136	(ABC) transporter
HLB41_23265	COG0577	efflux transmembrane transporter activity
HLB41_23270	COG3584	3D domain protein
HLB41_23270	COG1388	LysM domain
HLB41_23290	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLB41_23295	COG1447	Phosphotransferase system cellobiose-specific component IIA
HLB41_23300	COG3711	transcriptional antiterminator
HLB41_23300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLB41_23315	COG1283	sodium-dependent phosphate transmembrane transporter activity
HLB41_23320	COG0604	alcohol dehydrogenase
HLB41_23325	COG1316	TRANSCRIPTIONal
HLB41_23335	COG0730	response to heat
HLB41_23340	COG2210	Belongs to the sulfur carrier protein TusA family
HLB41_23345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLB41_23350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLB41_23350	COG0425	Belongs to the sulfur carrier protein TusA family
HLB41_23355	COG0425	Belongs to the sulfur carrier protein TusA family
HLB41_23360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLB41_23360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLB41_23365	COG0425	Belongs to the sulfur carrier protein TusA family
HLB41_23365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLB41_23370	COG1937	Protein conserved in bacteria
HLB41_23375	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLB41_23390	COG1414	Transcriptional regulator
HLB41_23400	COG2719	SpoVR family
HLB41_23405	COG0778	Nitroreductase
HLB41_23455	COG1609	Transcriptional regulator
HLB41_23460	COG1263	PTS System
HLB41_23460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLB41_23465	COG1621	beta-fructofuranosidase activity
HLB41_23470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLB41_23485	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_23490	COG2252	PERMEase
HLB41_23500	COG1129	ABC transporter
HLB41_23505	COG1172	Belongs to the binding-protein-dependent transport system permease family
HLB41_23520	COG1136	(ABC) transporter
HLB41_23545	COG1846	Transcriptional regulator
HLB41_23550	COG2814	Major facilitator Superfamily
HLB41_23555	COG2205	protein histidine kinase activity
HLB41_23595	COG0351	phosphomethylpyrimidine kinase
HLB41_23600	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HLB41_23610	COG2104	thiamine diphosphate biosynthetic process
HLB41_23615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLB41_23620	COG0352	thiamine-phosphate diphosphorylase activity
HLB41_23625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLB41_23630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLB41_23635	COG1116	anion transmembrane transporter activity
HLB41_23640	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HLB41_23660	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HLB41_23780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLB41_23790	COG0581	inorganic phosphate transmembrane transporter activity
HLB41_23795	COG0573	inorganic phosphate transmembrane transporter activity
HLB41_23800	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HLB41_23805	COG1918	ferrous iron import across plasma membrane
HLB41_23805	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HLB41_23810	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HLB41_23815	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HLB41_23825	COG0531	amino acid
HLB41_23830	COG0697	spore germination
HLB41_23835	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HLB41_23850	COG4990	cell redox homeostasis
HLB41_23855	COG0833	amino acid
HLB41_23865	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HLB41_23880	COG0475	glutathione-regulated potassium exporter activity
HLB41_23880	COG0569	domain protein
HLB41_23890	COG2153	protein acetylation
HLB41_23905	COG2252	PERMEase
HLB41_23910	COG1113	amino acid transport
HLB41_23925	COG1114	Component of the transport system for branched-chain amino acids
HLB41_23930	COG3104	oligopeptide transport
HLB41_23950	COG1476	TRANSCRIPTIONal
HLB41_23955	COG3584	3D domain protein
HLB41_23955	COG1388	LysM domain
HLB41_23960	COG0840	transmembrane signaling receptor activity
HLB41_24010	COG1063	alcohol dehydrogenase
HLB41_24030	COG1879	ABC-type sugar transport system periplasmic component
HLB41_24035	COG1172	Belongs to the binding-protein-dependent transport system permease family
HLB41_24050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLB41_24055	COG1609	Transcriptional regulator
HLB41_24060	COG0477	Major facilitator Superfamily
HLB41_24065	COG1846	Transcriptional regulator
HLB41_24070	COG2271	Major facilitator Superfamily
HLB41_24085	COG0659	secondary active sulfate transmembrane transporter activity
HLB41_24110	COG5002	protein histidine kinase activity
HLB41_24115	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HLB41_24120	COG2378	regulation of single-species biofilm formation
HLB41_24145	COG0833	amino acid
HLB41_24150	COG0765	amino acid transport
HLB41_24155	COG0765	amino acid transport
HLB41_24160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB41_24165	COG1126	abc transporter atp-binding protein
HLB41_24170	COG1115	amino acid carrier protein
HLB41_24175	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HLB41_24185	COG0697	spore germination
HLB41_24200	COG0366	Alpha amylase catalytic
HLB41_24205	COG1263	PTS System
HLB41_24205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLB41_24210	COG2188	Transcriptional regulator
HLB41_24215	COG0531	amino acid
HLB41_24235	COG0714	Associated with various cellular activities
HLB41_24240	COG4548	von Willebrand factor, type A
HLB41_24250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLB41_24270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB41_24275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB41_24280	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLB41_24285	COG3104	oligopeptide transport
HLB41_24300	COG1620	l-lactate permease
HLB41_24305	COG1027	Aspartate ammonia-lyase
HLB41_24310	COG1253	flavin adenine dinucleotide binding
HLB41_24315	COG0346	lactoylglutathione lyase activity
HLB41_24320	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HLB41_24325	COG1316	TRANSCRIPTIONal
HLB41_24330	COG2720	vancomycin resistance protein
HLB41_24350	COG3227	Zinc metalloprotease (Elastase)
HLB41_24370	COG2217	Heavy metal translocating P-type atpase
HLB41_24375	COG0640	Transcriptional regulator
HLB41_24380	COG0531	amino acid
HLB41_24395	COG2427	Protein of unknown function (DUF1641)
HLB41_24400	COG3383	formate dehydrogenase (NAD+) activity
HLB41_24405	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HLB41_24420	COG5002	protein histidine kinase activity
HLB41_24430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLB41_24435	COG0697	spore germination
HLB41_24445	COG0281	malic enzyme
HLB41_24450	COG3493	citrate carrier protein
HLB41_24455	COG4565	transcriptional regulatory protein
HLB41_24460	COG3290	protein histidine kinase activity
HLB41_24470	COG4990	cell redox homeostasis
HLB41_24480	COG5002	protein histidine kinase activity
HLB41_24485	COG0745	RESPONSE REGULATOR receiver
HLB41_24490	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HLB41_24500	COG0395	ABC-type sugar transport system, permease component
HLB41_24505	COG1175	transmembrane transport
HLB41_24510	COG3842	ATPase activity
HLB41_24515	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HLB41_24540	COG2851	Citrate transporter
HLB41_24545	COG4565	transcriptional regulatory protein
HLB41_24550	COG3290	protein histidine kinase activity
HLB41_24560	COG2268	Band 7 protein
HLB41_24565	COG1585	Membrane protein implicated in regulation of membrane protease activity
HLB41_24575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLB41_24595	COG2766	serine protein kinase
HLB41_24605	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HLB41_24630	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HLB41_24750	COG0735	belongs to the Fur family
HLB41_24755	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HLB41_24775	COG4555	ABC transporter
HLB41_24785	COG0070	glutamate synthase
HLB41_24785	COG0067	glutamate synthase
HLB41_24785	COG0069	glutamate synthase activity
HLB41_24790	COG4129	membrane
HLB41_24795	COG1132	(ABC) transporter
HLB41_24820	COG1194	a g-specific adenine glycosylase
HLB41_24825	COG1988	membrane-bound metal-dependent
HLB41_24855	COG1090	epimerase
HLB41_24860	COG1228	amidohydrolase
HLB41_24880	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HLB41_24900	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HLB41_24900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLB41_24910	COG0463	Glycosyl transferase, family 2
HLB41_24925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HLB41_24930	COG1263	PTS System
HLB41_24930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLB41_24960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLB41_24965	COG0833	amino acid
HLB41_24975	COG3829	transcription factor binding
HLB41_24990	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HLB41_24995	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HLB41_25015	COG0535	radical SAM domain protein
HLB41_25025	COG0387	Pfam Sodium calcium exchanger
HLB41_25030	COG3871	stress protein (general stress protein 26)
HLB41_25045	COG0586	Pfam SNARE associated Golgi protein
HLB41_25055	COG0681	Belongs to the peptidase S26 family
HLB41_25065	COG0697	spore germination
HLB41_25070	COG2217	Heavy metal translocating P-type atpase
HLB41_25075	COG1295	ribonuclease BN
HLB41_25085	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HLB41_25100	COG3853	Toxic anion resistance protein (TelA)
HLB41_25110	COG0861	Integral membrane protein TerC family
HLB41_25115	COG2310	stress, protein
HLB41_25120	COG2310	stress, protein
HLB41_25125	COG2310	stress, protein
HLB41_25155	COG2270	Major facilitator Superfamily
HLB41_25205	COG1116	anion transmembrane transporter activity
HLB41_25210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLB41_25215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLB41_25235	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HLB41_25265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLB41_25265	COG1263	PTS System
HLB41_25265	COG2190	(PTS) system
HLB41_25270	COG0366	Alpha amylase catalytic
HLB41_25275	COG0277	FAD linked oxidase domain protein
HLB41_25285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLB41_25290	COG0549	Belongs to the carbamate kinase family
HLB41_25315	COG0840	transmembrane signaling receptor activity
HLB41_25320	COG1126	abc transporter atp-binding protein
HLB41_25325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLB41_25330	COG0765	amino acid transport
HLB41_25340	COG0723	plastoquinol--plastocyanin reductase activity
HLB41_25340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLB41_25345	COG2814	Major facilitator Superfamily
HLB41_25350	COG3541	Predicted nucleotidyltransferase
HLB41_25370	COG5002	protein histidine kinase activity
HLB41_25395	COG0166	Belongs to the GPI family
HLB41_25405	COG0492	ferredoxin-NADP+ reductase activity
HLB41_25410	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLB41_25415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB41_25420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLB41_25440	COG0450	alkyl hydroperoxide reductase
HLB41_25455	COG1473	amidohydrolase
HLB41_25485	COG4807	Protein conserved in bacteria
HLB41_25500	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HLB41_25510	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HLB41_25530	COG2309	aminopeptidase activity
HLB41_25540	COG2076	Multidrug Resistance protein
HLB41_25545	COG1012	belongs to the aldehyde dehydrogenase family
HLB41_25555	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HLB41_25565	COG1597	lipid kinase activity
HLB41_25585	COG4682	membrane
HLB41_25590	COG1846	Transcriptional regulator
HLB41_25595	COG0003	Pfam Anion-transporting ATPase
HLB41_25610	COG1464	Belongs to the NlpA lipoprotein family
HLB41_25615	COG2011	ABC-type metal ion transport system permease component
HLB41_25625	COG1335	isochorismatase
HLB41_25640	COG4851	CamS sex pheromone cAM373 precursor
HLB41_25650	COG0210	DNA helicase
HLB41_25675	COG0151	Belongs to the GarS family
HLB41_25685	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HLB41_25695	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HLB41_25710	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HLB41_25720	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HLB41_25725	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HLB41_25730	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HLB41_25760	COG0697	spore germination
HLB41_25780	COG1215	transferase activity, transferring glycosyl groups
HLB41_25790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLB41_25800	COG2226	methyltransferase
HLB41_25830	COG0745	RESPONSE REGULATOR receiver
HLB41_25835	COG2205	protein histidine kinase activity
HLB41_25875	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HLB41_25900	COG5002	protein histidine kinase activity
HLB41_25910	COG2252	PERMEase
HLB41_25930	COG1266	CAAX protease self-immunity
HLB41_25945	COG0488	(ABC) transporter
HLB41_25955	COG0456	acetyltransferase
HLB41_25960	COG1214	PFAM Peptidase M22, glycoprotease
HLB41_25965	COG0802	atpase or kinase
HLB41_26065	COG2183	response to ionizing radiation
HLB41_26070	COG2337	Toxic component of a toxin-antitoxin (TA) module
HLB41_26075	COG0864	Transcriptional regulator
HLB41_26080	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HLB41_26085	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HLB41_26095	COG0705	Rhomboid family
HLB41_26100	COG4294	response to UV
HLB41_26110	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HLB41_26120	COG2814	Major facilitator Superfamily
HLB41_26125	COG0531	amino acid
HLB41_26135	COG0179	Fumarylacetoacetate (FAA) hydrolase
HLB41_26140	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HLB41_26170	COG0561	phosphatase activity
HLB41_26175	COG4608	Belongs to the ABC transporter superfamily
HLB41_26180	COG0444	Belongs to the ABC transporter superfamily
HLB41_26190	COG0601	transmembrane transport
HLB41_26195	COG0747	negative chemotaxis
HLB41_26205	COG0488	(ABC) transporter
HLB41_26225	COG5298	Protein conserved in bacteria
HLB41_26240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLB41_26250	COG1609	Transcriptional regulator
HLB41_26260	COG0204	Acyl-transferase
HLB41_26275	COG0697	spore germination
HLB41_26290	COG1910	domain protein
HLB41_26295	COG0725	ABC transporter, periplasmic molybdate-binding protein
HLB41_26300	COG4149	molybdate abc transporter
HLB41_26320	COG0656	L-ascorbic acid biosynthetic process
HLB41_26325	COG4166	transmembrane transport
HLB41_26330	COG4166	transmembrane transport
HLB41_26345	COG2207	Transcriptional regulator
HLB41_26355	COG4166	transmembrane transport
HLB41_26360	COG4608	Belongs to the ABC transporter superfamily
HLB41_26365	COG0444	Belongs to the ABC transporter superfamily
HLB41_26370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLB41_26375	COG0601	transmembrane transport
HLB41_26390	COG2814	Major facilitator Superfamily
HLB41_26400	COG2271	Major facilitator Superfamily
HLB41_26405	COG0277	FAD linked oxidase domain protein
HLB41_26415	COG0604	alcohol dehydrogenase
HLB41_26420	COG1464	Belongs to the NlpA lipoprotein family
HLB41_26425	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HLB41_26430	COG2011	ABC-type metal ion transport system permease component
HLB41_26435	COG1028	Short-chain dehydrogenase reductase Sdr
HLB41_26525	COG4856	YbbR-like protein
HLB41_26530	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HLB41_26610	COG0726	polysaccharide deacetylase
HLB41_26615	COG2194	sulfuric ester hydrolase activity
HLB41_26625	COG0489	protein tyrosine kinase activity
HLB41_26630	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLB41_26655	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HLB41_26690	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HLB41_26700	COG0024	Methionine aminopeptidase
HLB41_26710	COG0201	protein transport
HLB41_26770	COG0255	Belongs to the universal ribosomal protein uL29 family
HLB41_26835	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HLB41_26840	COG1358	cellular component organization or biogenesis
HLB41_26855	COG2813	Specifically methylates the guanine in position
HLB41_26875	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HLB41_26880	COG0250	Participates in transcription elongation, termination and antitermination
HLB41_26885	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HLB41_26900	COG3688	RNA-binding protein containing a PIN domain
HLB41_26905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLB41_26920	COG1045	serine acetyltransferase
HLB41_26940	COG4956	integral membrane protein (PIN domain superfamily)
HLB41_26950	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HLB41_26955	COG0542	response to heat
HLB41_26965	COG3880	PFAM UvrB UvrC protein
HLB41_27055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HLB41_27060	COG1396	sequence-specific DNA binding
HLB41_27065	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HLB41_27070	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HLB41_27075	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HLB41_27080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HLB41_27085	COG0512	Glutamine amidotransferase of anthranilate synthase
HLB41_27090	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HLB41_27095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HLB41_27110	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HLB41_27125	COG2208	phosphoserine phosphatase activity
HLB41_27140	COG1098	S1 RNA binding domain
HLB41_27160	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HLB41_27165	COG3956	TIGRFAM MazG family protein
HLB41_27170	COG2244	polysaccharide biosynthetic process
HLB41_27175	COG2002	toxin-antitoxin pair type II binding
HLB41_27180	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HLB41_27210	COG0251	oxidation-reduction process
HLB41_27215	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HLB41_27230	COG2217	Heavy metal translocating P-type atpase
HLB41_27235	COG1937	Protein conserved in bacteria
HLB41_27240	COG3443	Belongs to the bacterial solute-binding protein 9 family
HLB41_27240	COG0803	Belongs to the bacterial solute-binding protein 9 family
HLB41_27260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLB41_27310	COG3118	belongs to the thioredoxin family
HLB41_27330	COG1126	abc transporter atp-binding protein
HLB41_27335	COG2304	oxidoreductase activity
HLB41_27340	COG2132	Multicopper oxidase
HLB41_27345	COG0745	RESPONSE REGULATOR receiver
HLB41_27350	COG5002	protein histidine kinase activity
HLB41_27360	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLB41_27370	COG4974	Belongs to the 'phage' integrase family
HLB41_27385	COG0457	Tetratricopeptide repeat
HLB41_27505	COG3344	reverse transcriptase
HLB41_27525	COG3344	reverse transcriptase
HLB41_27575	COG1396	sequence-specific DNA binding
HLB41_27610	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HLB41_27615	COG0582	viral genome integration into host DNA
HLB41_27650	COG2003	Belongs to the UPF0758 family
HLB41_27725	COG3397	chitin binding
HLB41_27760	COG0791	NLP P60 protein
HLB41_27760	COG3103	Sh3 type 3 domain protein
HLB41_27760	COG1388	LysM domain
HLB41_27800	COG0640	Transcriptional regulator
HLB41_27925	COG3344	reverse transcriptase
HLB41_28065	COG3344	reverse transcriptase
HLB41_28175	COG4962	Type ii secretion system protein e
HLB41_28260	COG0640	Transcriptional regulator
HLB41_28275	COG2072	flavoprotein involved in K transport
HLB41_28285	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HLB41_28290	COG0589	response to stress
HLB41_28295	COG0659	secondary active sulfate transmembrane transporter activity
HLB41_28300	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HLB41_28315	COG0659	secondary active sulfate transmembrane transporter activity
HLB41_28330	COG2824	Alkylphosphonate utilization operon protein PhnA
HLB41_28350	COG0640	Transcriptional regulator
HLB41_28355	COG0798	PFAM Bile acid sodium symporter
HLB41_28445	COG3344	reverse transcriptase
HLB41_28525	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HLB41_28540	COG1063	alcohol dehydrogenase
HLB41_28545	COG1733	regulation of RNA biosynthetic process
HLB41_28555	COG3791	Glutathione-dependent formaldehyde-activating
HLB41_28565	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HLB41_28575	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HLB41_28580	COG2918	glutathione biosynthetic process
HLB41_28580	COG1181	Belongs to the D-alanine--D-alanine ligase family
HLB41_28620	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HLB41_28635	COG2918	glutathione biosynthetic process
HLB41_28635	COG1181	Belongs to the D-alanine--D-alanine ligase family
HLB41_28675	COG2311	Membrane
HLB41_28745	COG2002	toxin-antitoxin pair type II binding
HLB41_28780	COG4974	Belongs to the 'phage' integrase family
HLB41_28805	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HLB41_28835	COG4166	transmembrane transport
HLB41_28850	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HLB41_28930	COG0789	Transcriptional regulator
HLB41_28980	COG1733	regulation of RNA biosynthetic process
HLB41_28990	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HLB41_29000	COG1181	Belongs to the D-alanine--D-alanine ligase family
HLB41_29000	COG2918	glutathione biosynthetic process
HLB41_29030	COG1335	isochorismatase
HLB41_29035	COG4990	cell redox homeostasis
HLB41_29040	COG0745	RESPONSE REGULATOR receiver
HLB41_29090	COG0798	PFAM Bile acid sodium symporter
HLB41_29095	COG0640	Transcriptional regulator
HLB41_29115	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HLB41_29125	COG3620	sequence-specific DNA binding
HLB41_29130	COG0306	phosphate transporter
HLB41_29135	COG0640	Transcriptional regulator
HLB41_29150	COG1846	Transcriptional regulator