locus-tag class description DT426_00010 ENOG4108Z0C Uvrb UvrC protein DT426_00025 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) DT426_00035 ENOG4105CTP PilT protein domain protein DT426_00055 ENOG4105D7W serine acetyltransferase DT426_00070 ENOG4105C2N RNA methyltransferase TrmH family group 3 DT426_00075 ENOG4105M0M Tetracycline resistance protein DT426_00080 ENOG4105QIV RNA polymerase DT426_00095 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) DT426_00120 ENOG4107Y49 methyltransferase DT426_00130 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DT426_00135 ENOG4105XPM ribosomal protein DT426_00245 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) DT426_00270 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DT426_00280 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DT426_00290 ENOG41067V7 50S ribosomal protein L36 DT426_00315 ENOG4108JJB ABC transporter DT426_00320 ENOG4108JJB ABC transporter DT426_00325 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) DT426_00330 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DT426_00355 ENOG4105D1F ATP-binding protein DT426_00370 ENOG4108NMV polysaccharide deacetylase DT426_00450 ENOG4105C8B TIGR00159 family DT426_00455 ENOG4107U5W ybbr family DT426_00470 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) DT426_00490 ENOG4108PSK reductase DT426_00495 ENOG4108UMI ABC transporter, permease DT426_00500 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DT426_00505 ENOG4105D01 (LipO)protein DT426_00510 ENOG4105CB2 alcohol dehydrogenase DT426_00520 ENOG4105IQ5 FAD linked oxidase domain protein DT426_00535 ENOG4105C2C drug resistance transporter, Bcr CflA DT426_00555 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DT426_00560 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DT426_00565 ENOG4105C3U ABC transporter DT426_00570 ENOG4108JQ7 (ABC) transporter DT426_00590 ENOG4108J59 Extracellular solute-binding protein, family 5 DT426_00595 ENOG4108J59 Extracellular solute-binding protein, family 5 DT426_00615 ENOG4105E0C molybdate abc transporter DT426_00620 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DT426_00625 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family DT426_00655 ENOG4105F6E Acyl-transferase DT426_00675 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) DT426_00690 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) DT426_00710 ENOG4105C5H ABC transporter DT426_00725 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein DT426_00735 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DT426_00740 ENOG4105C3U ABC transporter DT426_00745 ENOG4108JQ7 (ABC) transporter DT426_00750 ENOG410667J hydrolase DT426_00780 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase DT426_00785 ENOG4105ERH Fumarylacetoacetate hydrolase DT426_00795 ENOG4105CUB amino acid DT426_00800 ENOG4108SC4 )-transporter DT426_00805 ENOG4105CPF Cell wall formation (By similarity) DT426_00810 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) DT426_00835 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein DT426_00840 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DT426_00850 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) DT426_00955 ENOG4105K8N protein family UPF0079, ATPase DT426_00960 ENOG41072GX Peptidase M22 Glycoprotease DT426_00965 ENOG410801F ribosomal-protein-alanine acetyltransferase DT426_00970 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DT426_00975 ENOG4105C5H ABC transporter DT426_00990 ENOG4108TYN CAAX amino terminal protease family protein DT426_01035 ENOG4105C7N Xanthine uracil vitamin C permease DT426_01045 ENOG4105BZU Histidine kinase DT426_01075 ENOG4107ZXU DSBA oxidoreductase DT426_01095 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DT426_01145 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DT426_01165 ENOG410631K Membrane DT426_01190 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) DT426_01195 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit DT426_01200 ENOG4105C83 adenylosuccinate lyase DT426_01210 ENOG4105VR9 phosphoribosylformylglycinamidine synthase DT426_01235 ENOG4108V3E phosphoribosylglycinamide formyltransferase DT426_01245 ENOG4105C12 Phosphoribosylglycinamide synthetase DT426_01270 ENOG4105C4R Atp-dependent dna helicase DT426_01295 ENOG4108W2Y isochorismatase DT426_01305 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DT426_01310 ENOG4108UMI ABC transporter, permease DT426_01315 ENOG4105D01 (LipO)protein DT426_01335 ENOG410834F Transcriptional regulator DT426_01340 ENOG4107I77 yiaA/B two helix domain DT426_01360 ENOG4105CBD Diacylglycerol kinase DT426_01370 ENOG4108JPW Aminotransferase DT426_01380 ENOG4105C26 Dehydrogenase DT426_01385 ENOG4105KPY Small multidrug resistance protein DT426_01410 ENOG4105D9N nucleoside DT426_01415 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DT426_01425 ENOG4108W15 Protein of unknown function (DUF1456) DT426_01445 ENOG4105DTQ mandelate racemase muconate lactonizing DT426_01455 ENOG4105DFD Na H antiporter DT426_01480 ENOG4105D3R alkyl hydroperoxide reductase DT426_01485 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) DT426_01490 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) DT426_01495 ENOG4107W7X Aldolase DT426_01500 ENOG4105EHG Permease protein DT426_01505 ENOG4105DQ5 transport system permease protein DT426_01510 ENOG4108V5C ABC transporter DT426_01540 ENOG4106UIA DT426_01545 ENOG4106UIA DT426_01560 ENOG4105BZU Histidine kinase DT426_01580 ENOG410756H nucleotidyltransferase DT426_01585 ENOG4105D2S major facilitator superfamily DT426_01600 ENOG4105E5Q amino acid AbC transporter DT426_01605 ENOG4105EAB amino acid AbC transporter DT426_01615 ENOG4105C8Q Methyl-accepting chemotaxis DT426_01630 ENOG4105DBV ornithine carbamoyltransferase DT426_01640 ENOG4105C5B carbamate kinase DT426_01645 ENOG4108W63 CRP FNR family transcriptional regulator DT426_01655 ENOG4105DNP FAD linked oxidase domain protein DT426_01665 ENOG4105CI1 PTS System DT426_01680 ENOG4105C9U ATP-dependent DNA helicase RecQ DT426_01695 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter DT426_01715 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DT426_01720 ENOG4105D2X ABC transporter substrate-binding protein DT426_01765 ENOG41062JF Transcriptional regulator DT426_01780 ENOG4105DEU major facilitator superfamily DT426_01810 ENOG4108N0M stress protein DT426_01815 ENOG4106FN3 tellurium resistance protein DT426_01820 ENOG4106FN3 tellurium resistance protein DT426_01825 ENOG4107TS3 membrane protein, TerC DT426_01830 ENOG4108TTB tellurium resistance protein DT426_01845 ENOG41068PA UPF0435 protein DT426_01850 ENOG4105KJF protein tyrosine phosphatase DT426_01860 ENOG4107U9T Pfam:Ribonuclease_BN DT426_01865 ENOG4105C59 p-type ATPase DT426_01870 ENOG4108IPJ Membrane DT426_01890 ENOG4107ZTW SNARE associated Golgi DT426_01905 ENOG410606W general stress protein DT426_01910 ENOG4105UPD Calcium Proton DT426_01945 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DT426_01960 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DT426_01970 ENOG4108JUB Transcriptional regulator DT426_01980 ENOG4108IQI permease DT426_02005 ENOG4105CSV Glutaminase DT426_02025 ENOG4108A04 Beta-lactamase DT426_02040 ENOG4105CKK Glycosyl transferase, family 2 DT426_02045 ENOG4107QQG Dehydrogenase DT426_02050 ENOG4105C3I Nad-dependent epimerase dehydratase DT426_02055 ENOG4105CKK Glycosyl transferase, family 2 DT426_02070 ENOG4105F1A Pyruvate formate-lyase DT426_02090 ENOG4105CI2 imidazolone-5-propionate hydrolase DT426_02095 ENOG4105ECP epimerase DT426_02125 ENOG41067AE Membrane-bound metal-dependent hydrolase DT426_02130 ENOG4105CEN a g-specific adenine glycosylase DT426_02135 ENOG4106BXE DT426_02155 ENOG4105BZ1 (ABC) transporter DT426_02160 ENOG4107NBY Membrane DT426_02165 ENOG4105CBC glutamate synthase DT426_02175 ENOG4108IUW ABC transporter DT426_02195 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DT426_02200 ENOG4105G5W regulator Fur family DT426_02320 ENOG4108JQC penicillin-binding protein 1A DT426_02325 ENOG4108R9S DSBA oxidoreductase DT426_02335 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) DT426_02345 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) DT426_02350 ENOG4105BZU Histidine kinase DT426_02355 ENOG4105CYN Serine protein kinase DT426_02370 ENOG4105C94 Transporter DT426_02385 ENOG4105DZ6 Band 7 protein DT426_02395 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism DT426_02400 ENOG4108MRH transcriptional regulatory protein DT426_02405 ENOG4105D4T Citrate transporter DT426_02430 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator DT426_02435 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DT426_02440 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component DT426_02445 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component DT426_02450 ENOG4105BZ7 extracellular solute-binding protein family 1 DT426_02455 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) DT426_02460 ENOG4108STX response regulator DT426_02465 ENOG4105US7 Histidine kinase DT426_02490 ENOG4108MRH transcriptional regulatory protein DT426_02500 ENOG4105C6K Malic enzyme DT426_02510 ENOG4108UZ3 Transporter DT426_02515 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DT426_02525 ENOG4105BZU Histidine kinase DT426_02550 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DT426_02555 ENOG4108JB9 formate dehydrogenase DT426_02575 ENOG4105CUB amino acid DT426_02585 ENOG4105C59 p-type ATPase DT426_02590 ENOG4105DAP Nicotinate phosphoribosyltransferase DT426_02620 ENOG41073R8 VanW family DT426_02625 ENOG4108KGH TRANSCRIPTIONal DT426_02630 ENOG4105D9N nucleoside DT426_02635 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase DT426_02640 ENOG4105C37 (CBS) domain DT426_02645 ENOG4108IJ0 Aspartate ammonia-lyase DT426_02650 ENOG4105DAA L-lactate DT426_02665 ENOG4105DUX Transporter DT426_02670 ENOG4108MES Periplasmic binding protein DT426_02675 ENOG4105DQ5 transport system permease protein DT426_02680 ENOG4108IHU transport system permease protein DT426_02685 ENOG4105E0A ABC, transporter DT426_02700 ENOG4105EXW epimerase dehydratase DT426_02710 ENOG4107T89 von Willebrand factor, type A DT426_02715 ENOG4105GMT ATPase associated with various cellular activities aaa_5 DT426_02720 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DT426_02730 ENOG4105BZU Histidine kinase DT426_02735 ENOG4105D5Q Arginine ornithine antiporter DT426_02740 ENOG4107414 GntR family transcriptional regulator DT426_02745 ENOG4105C5Y PTS System DT426_02750 ENOG4105CG3 alpha amylase, catalytic region DT426_02765 ENOG4105E1K spore germination protein DT426_02775 ENOG4105CRN Aminoglycoside phosphotransferase DT426_02780 ENOG4105BZG amino acid carrier protein DT426_02790 ENOG4105CDA abc transporter atp-binding protein DT426_02795 ENOG4105CT1 (ABC) transporter DT426_02800 ENOG4105EAD ABC transporter DT426_02805 ENOG4105DRP amino acid AbC transporter DT426_02810 ENOG4108IQI permease DT426_02835 ENOG4105D29 Helix-turn-helix type 11 domain protein DT426_02840 ENOG4105NAE bifunctional deaminase-reductase domain protein DT426_02845 ENOG4105BZU Histidine kinase DT426_02870 ENOG4105CHH sulfate transporter DT426_02875 ENOG41068KF Universal stress protein DT426_02885 ENOG4105CXY transporter DT426_02890 ENOG41067TZ transcriptional regulator, MarR family DT426_02895 ENOG4105C0R drug resistance transporter emrb qaca subfamily DT426_02900 ENOG4105ETE Transcriptional regulator (LacI family DT426_02905 ENOG4108RVA ribokinase DT426_02915 ENOG4105C2J ABC transporter DT426_02920 ENOG4105CNN ABC, transporter DT426_02925 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator DT426_02930 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DT426_02970 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) DT426_03000 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DT426_03005 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DT426_03010 ENOG41069ER domain protein DT426_03015 ENOG4105VZ8 Transcriptional regulator DT426_03020 ENOG4107D63 DT426_03035 ENOG4105DUX Transporter DT426_03055 ENOG4105C85 amino acid DT426_03060 ENOG4105C7N Xanthine uracil vitamin C permease DT426_03075 ENOG4105MA6 gCN5-related N-acetyltransferase DT426_03100 ENOG4105BZ9 Cytochrome C oxidase, subunit I DT426_03105 ENOG4105E2S oxidase) subunit II DT426_03125 ENOG4106CAD Protein of unknown function (DUF3311) DT426_03130 ENOG4105E1V na solute symporter DT426_03145 ENOG4108NHD germination protein DT426_03150 ENOG4105CE1 Ferrous iron transport protein b DT426_03155 ENOG4105CE1 Ferrous iron transport protein b DT426_03160 ENOG4105CE1 Ferrous iron transport protein b DT426_03165 ENOG4105CVA phosphate DT426_03170 ENOG4105C8U phosphate abc transporter DT426_03175 ENOG4105E2Z phosphate ABC transporter (Permease DT426_03305 ENOG41080XQ Signal transduction protein with cbs domains DT426_03325 ENOG4105ETU transcriptional activator (TenA DT426_03335 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DT426_03345 ENOG4108VEU Thiamine monophosphate synthase DT426_03350 ENOG41080HI glycine oxidase DT426_03365 ENOG4105D06 uba thif-type nad fad binding protein DT426_03370 ENOG4105DWF phosphomethylpyrimidine kinase DT426_03420 ENOG4108INS Transcriptional regulator DT426_03435 ENOG4105C7N Xanthine uracil vitamin C permease DT426_03445 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein DT426_03460 ENOG4105K63 Thioredoxin DT426_03480 ENOG4108B31 Spore germination protein DT426_03500 ENOG4107Y03 Nitroreductase DT426_03505 ENOG4105ED1 spovr family DT426_03515 ENOG4108TCS Glutamyl endopeptidase DT426_03525 ENOG4105XTG Pfam:DUF156 DT426_03530 ENOG4105VFE sira family DT426_03535 ENOG4107TPS domain protein DT426_03540 ENOG4105VFE sira family DT426_03545 ENOG4105VFE sira family DT426_03555 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase DT426_03560 ENOG41087NI Sulfite exporter TauE/SafE DT426_03570 ENOG4108KGH TRANSCRIPTIONal DT426_03600 ENOG4105EMD TRANSCRIPTIONal DT426_03605 ENOG4105VCP PTS System DT426_03610 ENOG4105VZJ PTS System DT426_03635 ENOG41069ER domain protein DT426_03640 ENOG4107RBB ABC transporter, permease DT426_03645 ENOG4105C19 ABC transporter DT426_03675 ENOG4105WEF catalase DT426_03710 ENOG4107T5V SNARE associated Golgi DT426_03740 ENOG4105CUB amino acid DT426_03745 ENOG4107RWR Sodium hydrogen exchanger DT426_03755 ENOG4106KNT transcriptional regulator DT426_03795 ENOG4108YXU transcriptional regulator AsnC family DT426_03800 ENOG4105CH7 arginosuccinase DT426_03805 ENOG4105UBK short-chain dehydrogenase reductase DT426_03810 ENOG4105W1Y Transcriptional regulator DT426_03815 ENOG4105KPY Small multidrug resistance protein DT426_03835 ENOG4107RKG DJ-1/PfpI family DT426_03840 ENOG4105CH6 catalase DT426_03850 ENOG4105D5Q Arginine ornithine antiporter DT426_03855 ENOG4105C26 Dehydrogenase DT426_03865 ENOG4105BZ1 (ABC) transporter DT426_03870 ENOG4105BZ1 (ABC) transporter DT426_03885 ENOG4105DRP amino acid AbC transporter DT426_03890 ENOG4105CDA abc transporter atp-binding protein DT426_03905 ENOG410839P DT426_03935 ENOG4105K7K Transcriptional regulator DT426_03950 ENOG4105CJA serine threonine protein kinase DT426_03955 ENOG4105BZ1 (ABC) transporter DT426_03965 ENOG4107FQX Alpha-acetolactate decarboxylase DT426_03990 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DT426_03995 ENOG4105D4P Coproporphyrinogen iii oxidase DT426_04000 ENOG4105CEY Amp-dependent synthetase and ligase DT426_04015 ENOG4105CHH sulfate transporter DT426_04040 ENOG4105CGU Enoyl-CoA hydratase DT426_04060 ENOG4105DER m42 family DT426_04085 ENOG4105CIF Ornithine Cyclodeaminase DT426_04100 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DT426_04110 ENOG4108JQ7 (ABC) transporter DT426_04160 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase DT426_04175 ENOG4105D06 uba thif-type nad fad binding protein DT426_04180 ENOG4107SFI Major Facilitator superfamily DT426_04230 ENOG4108IBT Inherit from COG: transposase DT426_04340 ENOG4108IBT Inherit from COG: transposase DT426_04390 ENOG4105CSH Transporter DT426_04400 ENOG4108MRH transcriptional regulatory protein DT426_04440 ENOG4105CVR type I restriction-modification system DT426_04450 ENOG4105DZR Type I site-specific deoxyribonuclease DT426_04460 ENOG4105C4R Atp-dependent dna helicase DT426_04465 ENOG4105C4R Atp-dependent dna helicase DT426_04485 ENOG4105EB3 Histidine kinase DT426_04500 ENOG4105DVF Cytosine-specific methyltransferase DT426_04510 ENOG4105CDU Replicative dna helicase DT426_04535 ENOG4105C0R drug resistance transporter emrb qaca subfamily DT426_04645 ENOG4107P5I polyketide synthase DT426_04650 ENOG4108IG5 Transcriptional regulator DT426_04665 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DT426_04685 ENOG4105CMT Dihydroxyacetone kinase DT426_04700 ENOG4105CMT Dihydroxyacetone kinase DT426_04710 ENOG410847I Transcriptional regulator, BadM Rrf2 family DT426_04815 ENOG4105WN5 stage II sporulation protein DT426_04825 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DT426_04835 ENOG4108MJI response regulator DT426_04845 ENOG4105BZU Histidine kinase DT426_04850 ENOG4105BZU Histidine kinase DT426_04890 ENOG4105ENE Histidine kinase DT426_04895 ENOG4108VB1 regulatoR DT426_04920 ENOG4107VRP DNA repair exonuclease DT426_04925 ENOG4106D4I domain protein DT426_04940 ENOG410829K Lysine exporter protein (Lyse ygga) DT426_04955 ENOG4107JM4 Tetratricopeptide repeat DT426_04965 ENOG4108MUZ hydrolase DT426_04990 ENOG4105F0F Oxalate decarboxylase DT426_04995 ENOG41067QW Transcriptional regulator DT426_05000 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator DT426_05015 ENOG4105C6V Glycerol-3-phosphate dehydrogenase DT426_05020 ENOG4105K7K Transcriptional regulator DT426_05030 ENOG4105EMN RNA polymerase sigma factor DT426_05045 ENOG4105EEM helicase DT426_05050 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DT426_05080 ENOG4105K59 histidine triad (HIT) protein DT426_05110 ENOG410905X membrane-flanked domain protein DT426_05115 ENOG4105CKV Membrane DT426_05155 ENOG410905X membrane-flanked domain protein DT426_05160 ENOG4105CKV Membrane DT426_05165 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation DT426_05170 ENOG4105BZ4 penicillin-binding protein DT426_05180 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) DT426_05185 ENOG4105C1Q protoporphyrinogen oxidase DT426_05215 ENOG4105ECB domain protein DT426_05245 ENOG4106AXD DT426_05250 ENOG4108RQ5 Beta-lactamase domain-containing protein DT426_05255 ENOG4105DF9 Lipoate-protein, ligase DT426_05265 ENOG4105CEY Amp-dependent synthetase and ligase DT426_05300 ENOG4105ENX hydrolase DT426_05305 ENOG4107RN3 metallophosphoesterase DT426_05310 ENOG4107TVP HD domain protein DT426_05325 ENOG4108AEY RNA polymerase sigma factor DT426_05335 ENOG41086D8 Transcriptional regulator DT426_05350 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DT426_05370 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 DT426_05375 ENOG4105C8Q Methyl-accepting chemotaxis DT426_05385 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) DT426_05395 ENOG4107QP3 malate synthase g DT426_05415 ENOG4105VEQ Cold shock protein DT426_05450 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation DT426_05455 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DT426_05495 ENOG4105ERH Fumarylacetoacetate hydrolase DT426_05505 ENOG4105C8Y Acetylornithine aminotransferase DT426_05540 ENOG4105CAQ asparagine synthetase DT426_05545 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) DT426_05550 ENOG4105CH6 catalase DT426_05555 ENOG4105BZU Histidine kinase DT426_05580 ENOG4105QNR S1 RNA binding domain protein DT426_05675 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DT426_05685 ENOG4107AYK membrAne DT426_05690 ENOG41073B9 DT426_05700 ENOG4108KP7 hydrolase DT426_05710 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DT426_05735 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DT426_05740 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DT426_05755 ENOG4105C31 Tryptophanyl-tRNA synthetase DT426_05780 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DT426_05785 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DT426_05795 ENOG4108JQ7 (ABC) transporter DT426_05800 ENOG4105UQX Mate efflux family protein DT426_05830 ENOG4108ZCF integral membrane protein DT426_05840 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DT426_05850 ENOG4105DPN Oligoendopeptidase f DT426_05860 ENOG4108Z18 K06886 hemoglobin DT426_05865 ENOG4105MIX Adenylate cyclase DT426_05880 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DT426_05885 ENOG4105EMS pseudouridine synthase DT426_05905 ENOG4105K64 Glycosyl transferase, family 2 DT426_05925 ENOG4107TVC Glycosyl transferase, family 2 DT426_05945 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) DT426_05950 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase DT426_05960 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase DT426_06035 ENOG4105CK7 Sodium proline symporter DT426_06045 ENOG4105CRQ synthase (Component I) DT426_06050 ENOG4105DDQ anthranilate synthase DT426_06150 ENOG4105C7S Dehydrogenase DT426_06160 ENOG4105VZ8 Transcriptional regulator DT426_06205 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) DT426_06215 ENOG4105DZ1 carboxypeptidase DT426_06220 ENOG4105VFR signal peptidase DT426_06255 ENOG4105C26 Dehydrogenase DT426_06260 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DT426_06265 ENOG4105F38 ABC transporter, permease DT426_06270 ENOG4105D38 putrescine abc transporter DT426_06275 ENOG4107RUE extracellular solute-binding protein family 1 DT426_06280 ENOG410841Q phosphoesterase PA-phosphatase related protein DT426_06285 ENOG4105EYF MMPL domain protein DT426_06295 ENOG4108YBP pseudouridine synthase DT426_06305 ENOG4105K4I Scp-like extracellular DT426_06310 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DT426_06315 ENOG4105CQB FAD linked oxidase domain protein DT426_06330 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DT426_06335 ENOG4105BZU Histidine kinase DT426_06340 ENOG4105JXH GntR family transcriptional regulator DT426_06360 ENOG4106A3R peptidase DT426_06370 ENOG4108QTI )-transporter DT426_06375 ENOG4107TS3 membrane protein, TerC DT426_06380 ENOG4105CZN Potassium uptake protein DT426_06385 ENOG410681C small acid-soluble spore protein DT426_06390 ENOG4108Z7G MaoC domain protein dehydratase DT426_06410 ENOG4105CHR reductase DT426_06440 ENOG4105C4Y ABC transporter DT426_06445 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DT426_06450 ENOG4107RCV ABC transporter, permease DT426_06470 ENOG4105E98 transcriptional regulator DeoR family DT426_06480 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) DT426_06490 ENOG4105PXI polysaccharide deacetylase DT426_06500 ENOG4105BZU Histidine kinase DT426_06505 ENOG41090MY MarR family Transcriptional regulator DT426_06515 ENOG4106DF1 DT426_06520 ENOG4105BZU Histidine kinase DT426_06530 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase DT426_06535 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) DT426_06575 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) DT426_06580 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DT426_06595 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DT426_06600 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DT426_06605 ENOG4105CZV ABC transporter DT426_06615 ENOG4105CJ1 ABC, transporter DT426_06655 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DT426_06660 ENOG4105EA8 2-Nitropropane dioxygenase DT426_06665 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD DT426_06675 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein DT426_06695 ENOG4105NQC Flavodoxin DT426_06725 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DT426_06755 ENOG4105CZN Potassium uptake protein DT426_06760 ENOG41063Y9 DT426_06765 ENOG4105KBJ sporulation protein ytfj DT426_06785 ENOG4105CM2 brancheD-chain amino acid aminotransferase DT426_06790 ENOG4105C7K acetolactate synthase DT426_06795 ENOG4108ZP8 Acetolactate synthase small subunit DT426_06800 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase DT426_06835 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) DT426_06870 ENOG4107RVV histidinol phosphate phosphatase, hisj family DT426_06885 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DT426_06890 ENOG4105E0M Sulfatase DT426_06900 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DT426_06920 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) DT426_06925 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) DT426_06935 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DT426_06940 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein DT426_06945 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein DT426_06950 ENOG4105C8J )-transporter DT426_06970 ENOG4105DFD Na H antiporter DT426_06990 ENOG4105ENE Histidine kinase DT426_06995 ENOG4105WH1 Two component transcriptional regulator luxr family DT426_07015 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DT426_07040 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DT426_07060 ENOG4105CJ3 phosphate transporter DT426_07065 ENOG4107GRR phosphate transport regulator DT426_07070 ENOG4105BZ4 penicillin-binding protein DT426_07085 ENOG4105BZU Histidine kinase DT426_07090 ENOG4105I3N Conserved Protein DT426_07105 ENOG4105BZU Histidine kinase DT426_07135 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DT426_07140 ENOG4105DZ1 carboxypeptidase DT426_07145 ENOG4108JIC nucleoside recognition domain protein DT426_07155 ENOG4105FE9 pseudouridine synthase DT426_07160 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DT426_07165 ENOG4107TWT Cytochrome c biogenesis protein DT426_07170 ENOG4105CRE cytochrome C DT426_07175 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DT426_07180 ENOG4105BZU Histidine kinase DT426_07185 ENOG4108WBT adenosyltransferase DT426_07200 ENOG4108SAX Membrane DT426_07215 ENOG4105C9U ATP-dependent DNA helicase RecQ DT426_07220 ENOG4105I7S Abortive infection protein DT426_07230 ENOG4107RGJ metallophosphoesterase DT426_07235 ENOG4108XDN Transcriptional regulator DT426_07240 ENOG4108S6Z Negative regulator of genetic competence DT426_07265 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase DT426_07270 ENOG4107RB3 L-asparaginase DT426_07300 ENOG4105S2F DT426_07305 ENOG41065D1 DT426_07335 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) DT426_07350 ENOG4105XXQ heptaprenyl diphosphate synthase component I DT426_07360 ENOG4105EAH synthase DT426_07365 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) DT426_07370 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase DT426_07390 ENOG41068YB TPR repeat-containing protein DT426_07405 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) DT426_07410 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) DT426_07445 ENOG4108JYZ YitT family DT426_07450 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase DT426_07465 ENOG4105FJR Lmbe family DT426_07470 ENOG4105CPK Glycosyl transferase (Group 1 DT426_07505 ENOG4105DVT helicase DT426_07510 ENOG4105YAC DT426_07530 ENOG4105CSM endonuclease III DT426_07540 ENOG4105BZ4 penicillin-binding protein DT426_07595 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) DT426_07605 ENOG4105DVT helicase DT426_07610 ENOG4105CTD carboxy-peptidase DT426_07625 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DT426_07635 ENOG4105C2W permease DT426_07640 ENOG4105DHF Membrane DT426_07645 ENOG410890F Dynamin family DT426_07655 ENOG4108W0I acetyltransferase DT426_07665 ENOG4105KHC sulfurtransferase DT426_07690 ENOG4106032 Glutathionylspermidine synthase DT426_07725 ENOG4105HTX biosynthesis protein DT426_07755 ENOG4105CPK Glycosyl transferase (Group 1 DT426_07770 ENOG4108SZE gCN5-related N-acetyltransferase DT426_07790 ENOG41081VK Ribonuclease DT426_07855 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DT426_07865 ENOG4107RWR Sodium hydrogen exchanger DT426_07870 ENOG4105CN5 Metallo-Beta-Lactamase DT426_07875 ENOG4108Z5V transcriptional regulator, merr family DT426_07885 ENOG4105H67 Protein of unknown function (DUF421) DT426_07890 ENOG41080C8 DUF218 domain DT426_07925 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) DT426_07935 ENOG4107R0U MotA TolQ exbB proton channel DT426_07940 ENOG4105ER2 Ompa motb domain protein DT426_07945 ENOG4107YTP response regulator receiver protein DT426_07950 ENOG4105CBS Chea signal transduction histidine kinase DT426_07955 ENOG4105DD5 Flagellar motor switch protein DT426_07970 ENOG4105BZU Histidine kinase DT426_07990 ENOG4105E1Q flagellar hook-associated protein DT426_07995 ENOG4105DTJ flagellar hook-associated protein DT426_08000 ENOG4105DTS flagellar hook-associated DT426_08015 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) DT426_08020 ENOG4108ZC9 flagellar basal-body rod protein flgc DT426_08025 ENOG41075Z6 flagellar hook-basal body complex protein fliE DT426_08030 ENOG4107U2N Flagellar M-ring protein DT426_08035 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DT426_08065 ENOG4105BZE flagellar hook protein, FlgE DT426_08080 ENOG4107R88 Chemotaxis protein (CheV) DT426_08090 ENOG4105I03 Flagellin DT426_08095 ENOG4105I03 Flagellin DT426_08100 ENOG4105E4C Lytic transglycosylase catalytic DT426_08110 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DT426_08115 ENOG4105DD5 Flagellar motor switch protein DT426_08125 ENOG4105CN7 Flagellar biosynthetic protein FliP DT426_08130 ENOG4105VS8 Flagellar biosynthetic protein fliq DT426_08140 ENOG4105D00 flagellar biosynthetic protein flhB DT426_08145 ENOG4105D7B Flagellar biosynthesis protein flha DT426_08150 ENOG4105FZW flagellar biosynthesis regulator FlhF DT426_08155 ENOG4105KTQ flagellar basal-body rod protein DT426_08160 ENOG4105CPU Monooxygenase DT426_08165 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DT426_08195 ENOG4105KAC Antibiotic biosynthesis monooxygenase DT426_08200 ENOG4107QZ7 Cellulose synthase catalytic subunit DT426_08225 ENOG4105DUM transcriptional regulator, lysR family DT426_08230 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DT426_08240 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component DT426_08285 ENOG4105CVJ phosphoglycerate mutase DT426_08295 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) DT426_08305 ENOG4105K56 Transcriptional regulator DT426_08315 ENOG4105CAQ asparagine synthetase DT426_08335 ENOG4105PGM cation diffusion facilitator family transporter DT426_08355 ENOG4105CKI cobalamin synthesis protein DT426_08365 ENOG4108PJD permease DT426_08380 ENOG4105DFD Na H antiporter DT426_08385 ENOG4105VUF Transcriptional regulator DT426_08395 ENOG4105C9Q fumarate hydratase class II DT426_08415 ENOG4107QJQ Mate efflux family protein DT426_08420 ENOG4105EC3 peptidase S51, dipeptidase E DT426_08440 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DT426_08610 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DT426_08645 ENOG4105K63 Thioredoxin DT426_08670 ENOG4105C2M dna polymerase I DT426_08730 ENOG4106BRA Membrane DT426_08770 ENOG4105CJ1 ABC, transporter DT426_08790 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) DT426_08800 ENOG4108IJ0 Aspartate ammonia-lyase DT426_08805 ENOG4105C6K Malic enzyme DT426_08865 ENOG4105FVX DT426_08870 ENOG4105E09 nadh pyrophosphatase DT426_08885 ENOG4105CSR polyphosphate kinase 2 DT426_08890 ENOG4105U3E Transcriptional regulator DT426_08900 ENOG4105DXI Major Facilitator superfamily DT426_08910 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DT426_08915 ENOG4105EU0 Major facilitator Superfamily DT426_08920 ENOG4105C6T cysteine synthase DT426_08940 ENOG4105C8J )-transporter DT426_08950 ENOG4105X5K response regulator receiver protein DT426_08955 ENOG4105H67 Protein of unknown function (DUF421) DT426_08980 ENOG4105CHR reductase DT426_08985 ENOG4105CM2 brancheD-chain amino acid aminotransferase DT426_08990 ENOG4105C7K acetolactate synthase DT426_09000 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase DT426_09010 ENOG4105C7B Threonine dehydratase DT426_09035 ENOG4105C6X Major Facilitator DT426_09040 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b DT426_09055 ENOG4105DY9 regulatoR DT426_09060 ENOG4105CYC Transferase DT426_09085 ENOG41068WN DT426_09105 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) DT426_09120 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) DT426_09125 ENOG4105C0X amino acid DT426_09160 ENOG410849A acetyltransferase, (GNAT) family DT426_09170 ENOG4105K8R UPF0145 protein DT426_09185 ENOG4107RHR regulatoR DT426_09195 ENOG4105D9N nucleoside DT426_09200 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) DT426_09220 ENOG4107RAQ aminopeptidase DT426_09230 ENOG4107R16 Multicopper oxidase DT426_09275 ENOG4108T5E Copper resistance protein DT426_09280 ENOG4105KTB nuclear export factor GLE1 DT426_09285 ENOG4107RT3 EamA-like transporter family DT426_09290 ENOG4105GZI Transcriptional regulator DT426_09295 ENOG4108Z40 Transcriptional regulator DT426_09300 ENOG4107ZXU DSBA oxidoreductase DT426_09305 ENOG4108TVJ Nitroreductase DT426_09310 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DT426_09315 ENOG4106F5Q Membrane DT426_09320 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DT426_09335 ENOG4105CKI cobalamin synthesis protein DT426_09345 ENOG4105C0Z ABC transporter DT426_09350 ENOG4108IV0 ABC, transporter DT426_09355 ENOG4105C32 Amino acid ABC transporter (Permease) DT426_09365 ENOG4105SKE transcriptional Regulator LysR family DT426_09375 ENOG4105MDS 4-oxalocrotonate tautomerase DT426_09395 ENOG4105C4M (Ubiquinol oxidase) subunit I DT426_09400 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DT426_09405 ENOG4108JJ9 ABC, transporter DT426_09410 ENOG4108JJ8 (ABC) transporter DT426_09420 ENOG4105K64 Glycosyl transferase, family 2 DT426_09430 ENOG4108UT6 Transferase hexapeptide repeat containing protein DT426_09485 ENOG4105BZ1 (ABC) transporter DT426_09490 ENOG4105EFI regulatoR DT426_09495 ENOG4105BZU Histidine kinase DT426_09505 ENOG4108VQJ O-methyltransferase DT426_09520 ENOG41075D4 Aminoglycoside 6-adenylyltransferase DT426_09525 ENOG4108ZJ4 polysaccharide deacetylase DT426_09545 ENOG4105D6E homoserine dehydrogenase DT426_09570 ENOG4108KGH TRANSCRIPTIONal DT426_09575 ENOG4107VMI polysaccharide deacetylase DT426_09585 ENOG4105KT7 mgtC SapB transporter DT426_09600 ENOG4105VRR gCN5-related N-acetyltransferase DT426_09610 ENOG4105DUU IucA IucC family protein DT426_09615 ENOG4105CEY Amp-dependent synthetase and ligase DT426_09630 ENOG4108WBH protein TIM barrel DT426_09635 ENOG4105YWU small acid-soluble spore protein DT426_09645 ENOG4108ZUB Lysine exporter protein (Lyse ygga) DT426_09650 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DT426_09700 ENOG4105KRN Transcriptional regulator, abrb family DT426_09710 ENOG4105YVS arsR family transcriptional regulator DT426_09715 ENOG4105CPC Aldo Keto reductase DT426_09750 ENOG4105C8Q Methyl-accepting chemotaxis DT426_09770 ENOG4108K88 Membrane DT426_09775 ENOG4108WPJ Ferritin-like domain DT426_09790 ENOG4105DEN Luciferase family DT426_09805 ENOG4105VMI -acetyltransferase DT426_09810 ENOG4107QM2 Aldo Keto reductase DT426_09815 ENOG4105CKI cobalamin synthesis protein DT426_09825 ENOG4105DSE periplasmic solute binding protein DT426_09835 ENOG4105K4T epimerase DT426_09845 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DT426_09870 ENOG4105CVJ phosphoglycerate mutase DT426_09890 ENOG4107T5V SNARE associated Golgi DT426_09905 ENOG4108PJD permease DT426_09915 ENOG4108S4H thioesterase Superfamily protein DT426_09925 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DT426_09945 ENOG4105SXS Protein of unknown function (DUF456) DT426_09950 ENOG4105C37 (CBS) domain DT426_09980 ENOG4108Z7R Chaperone CsaA DT426_10000 ENOG4108ZRV stage ii sporulation protein p DT426_10010 ENOG4108VXD carboxy-peptidase DT426_10040 ENOG4108ZRV stage ii sporulation protein p DT426_10050 ENOG4108X4Q Hydrolase DT426_10055 ENOG41082F9 transcriptional regulator DT426_10060 ENOG4105D94 Major Facilitator Superfamily DT426_10070 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DT426_10075 ENOG4107RBS Methyltransferase DT426_10090 ENOG41087PP glycosyltransferase MGT family DT426_10095 ENOG4108JYZ YitT family DT426_10100 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DT426_10130 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) DT426_10150 ENOG4106PAW secretion accessory protein EsaA YueB DT426_10160 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) DT426_10165 ENOG4108MGT Required for secretion of EsxA and EsxB DT426_10265 ENOG4105KBJ sporulation protein ytfj DT426_10290 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DT426_10310 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) DT426_10315 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily DT426_10325 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein DT426_10330 ENOG4105EMN RNA polymerase sigma factor DT426_10340 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) DT426_10350 ENOG4105CNW domain protein DT426_10360 ENOG4108V06 Glutathione peroxidase DT426_10375 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DT426_10385 ENOG4108IUE nitrate reductase beta subunit DT426_10390 ENOG4105R3A Nitrate reductase DT426_10400 ENOG4107V6Q Cyclic nucleotide-binding domain DT426_10405 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DT426_10410 ENOG4105D06 uba thif-type nad fad binding protein DT426_10415 ENOG4105CVM Molybdenum cofactor synthesis domain protein DT426_10420 ENOG4108ZAF Molybdopterin DT426_10445 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein DT426_10450 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein DT426_10455 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DT426_10460 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit DT426_10465 ENOG4108IFG nitrite reductase, (NAD(P)H) DT426_10470 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) DT426_10505 ENOG4105MCT stage V sporulation protein S DT426_10545 ENOG4105C5H ABC transporter DT426_10560 ENOG4108UUM single-stranded DNA-binding protein DT426_10585 ENOG4107YX5 Pfam:DUF548 DT426_10590 ENOG4105C75 arginyL-tRNA synthetase DT426_10605 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DT426_10625 ENOG4105C5S asparaginyl-tRNA synthetase DT426_10630 ENOG4105C8J )-transporter DT426_10635 ENOG4108EF6 Proline imino-peptidase DT426_10650 ENOG4107XGZ Hydrolase DT426_10655 ENOG4105CY2 Citrate transporter DT426_10675 ENOG4105KD7 acetyltransferase DT426_10685 ENOG4105VMP Transcriptional regulator DT426_10690 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase DT426_10715 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 DT426_10745 ENOG4107RVG penicillin-binding protein DT426_10755 ENOG4105E9Q Acyl-transferase DT426_10760 ENOG4108UT2 hemolysin iii DT426_10770 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DT426_10780 ENOG4108RCR degv family DT426_10790 ENOG4108KF3 Electron transport protein SCO1 SenC DT426_10795 ENOG4107Y70 Heat shock protein DT426_10800 ENOG4105CAQ asparagine synthetase DT426_10815 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DT426_10820 ENOG4108MES Periplasmic binding protein DT426_10825 ENOG4105F0I Aminotransferase DT426_10855 ENOG4105D8X mechanosensitive ion channel DT426_10860 ENOG4105BZU Histidine kinase DT426_10865 ENOG4105WH1 Two component transcriptional regulator luxr family DT426_10870 ENOG4106KNT transcriptional regulator DT426_10875 ENOG4107ZY0 Phenazine biosynthesis-like protein DT426_10895 ENOG4105CMG Carbohydrate kinase DT426_10900 ENOG4105C6Z Gluconate DT426_10910 ENOG4108YV3 Protein of unknown function (DUF2711) DT426_10940 ENOG4108IJ8 ABC transporter DT426_10945 ENOG4105E90 ABC transporter DT426_10980 ENOG4105C37 (CBS) domain DT426_11005 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DT426_11020 ENOG4107S4Y M20 DapE family protein YgeY DT426_11025 ENOG4108TSC N-acetyltransferase DT426_11030 ENOG4108JUB Transcriptional regulator DT426_11040 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein DT426_11085 ENOG410841Q phosphoesterase PA-phosphatase related protein DT426_11095 ENOG4105SZ6 Thioredoxin DT426_11100 ENOG4105KNA -acetyltransferase DT426_11155 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DT426_11210 ENOG4105BZ4 penicillin-binding protein DT426_11220 ENOG4105CZM Major Facilitator DT426_11225 ENOG4105W8X HesB YadR YfhF-family protein DT426_11235 ENOG4105DXD 2-methylcitrate dehydratase DT426_11240 ENOG4105CR4 methylisocitrate lyase DT426_11245 ENOG4105C1G acyl-Coa dehydrogenase DT426_11250 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DT426_11260 ENOG4105N14 lysine exporter protein LysE YggA DT426_11265 ENOG4105E39 Enoyl-CoA hydratase DT426_11280 ENOG4107RFY SbcCD D subunit DT426_11285 ENOG4105EYH Exonuclease DT426_11300 ENOG4105FCD Major Facilitator DT426_11305 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase DT426_11310 ENOG4105E4F Isochorismate synthase DT426_11315 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase DT426_11320 ENOG4105WQI isochorismatase DT426_11325 ENOG4105CEY Amp-dependent synthetase and ligase DT426_11335 ENOG4105C0R drug resistance transporter emrb qaca subfamily DT426_11350 ENOG4105K70 DNA-binding protein DT426_11370 ENOG4105BZG amino acid carrier protein DT426_11390 ENOG4105FE9 pseudouridine synthase DT426_11395 ENOG4105C22 threonyL-tRNA synthetase DT426_11400 ENOG4105C19 ABC transporter DT426_11435 ENOG41081I9 integral membrane protein DT426_11445 ENOG4108Y4K DNA-binding transcriptional activator DT426_11460 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DT426_11470 ENOG4105EYF MMPL domain protein DT426_11495 ENOG4105WCN acetyltransferase DT426_11520 ENOG4105C1Q protoporphyrinogen oxidase DT426_11530 ENOG41068WN DT426_11560 ENOG4107V2S Transcriptional regulator DT426_11565 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DT426_11580 ENOG4105DND Transcriptional regulator DT426_11585 ENOG4108RPX mosc domain containing protein DT426_11600 ENOG4105BZ1 (ABC) transporter DT426_11605 ENOG4105BZ1 (ABC) transporter DT426_11630 ENOG4108VP3 Lysine exporter protein (LysE YggA) DT426_11635 ENOG4108JCI Transcriptional regulator DT426_11665 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) DT426_11670 ENOG4108KPJ rna polymerase sigma factor DT426_11690 ENOG4105F32 YngK protein DT426_11715 ENOG4105RD7 BadF BadG BcrA BcrD DT426_11720 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) DT426_11725 ENOG4107STF Involved in phosphonate degradation (By similarity) DT426_11730 ENOG4105C7B Threonine dehydratase DT426_11735 ENOG4108INS Transcriptional regulator DT426_11750 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DT426_11760 ENOG4105C1J atp-dependent rna helicase DT426_11765 ENOG41088CC tellurite resistance protein tehB DT426_11775 ENOG4108I0C methyltransferase DT426_11815 ENOG4105CIN aminoacyl-histidine dipeptidase DT426_11840 ENOG4105KRN Transcriptional regulator, abrb family DT426_11850 ENOG4105EJ9 Membrane DT426_11895 ENOG4105W8Z 4'-phosphopantetheinyl transferase DT426_11905 ENOG4105CHR reductase DT426_11980 ENOG4108W0I acetyltransferase DT426_11985 ENOG4107QQG Dehydrogenase DT426_11990 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DT426_11995 ENOG4108IAJ Nad-dependent epimerase dehydratase DT426_12000 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DT426_12015 ENOG4105FJR Lmbe family DT426_12025 ENOG4105IIU Aminopeptidase DT426_12030 ENOG4108SC4 )-transporter DT426_12075 ENOG4108IMY Transcriptional regulator DT426_12085 ENOG4107VMI polysaccharide deacetylase DT426_12125 ENOG4107RVG penicillin-binding protein DT426_12140 ENOG4107RF6 penicillin-binding protein DT426_12145 ENOG4107RF6 penicillin-binding protein DT426_12155 ENOG4105DIN metallophosphoesterase DT426_12165 ENOG4105CJ1 ABC, transporter DT426_12175 ENOG4107Z3H Transcriptional regulator, TetR family DT426_12190 ENOG4105C1G acyl-Coa dehydrogenase DT426_12195 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DT426_12200 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit DT426_12205 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase DT426_12210 ENOG4105E39 Enoyl-CoA hydratase DT426_12215 ENOG4107QX3 carboxylase DT426_12220 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DT426_12240 ENOG4105DBI uridine monophosphokinase DT426_12260 ENOG4105DZ1 carboxypeptidase DT426_12285 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) DT426_12305 ENOG41075H3 AraC family transcriptional regulator DT426_12335 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DT426_12345 ENOG4105CHR reductase DT426_12350 ENOG4105KVH Transcriptional regulator DT426_12420 ENOG410900G Protein of unknown function (DUF421) DT426_12430 ENOG4108V4B ThiJ pfpI DT426_12440 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein DT426_12450 ENOG4105DK7 lysyl-tRNA synthetase DT426_12475 ENOG4106NZI LysR family Transcriptional regulator DT426_12480 ENOG4105CPC Aldo Keto reductase DT426_12520 ENOG4105D6E homoserine dehydrogenase DT426_12530 ENOG4105CPF Cell wall formation (By similarity) DT426_12535 ENOG4105ETU transcriptional activator (TenA DT426_12570 ENOG4105VTR Integrase DT426_12585 ENOG4108IMY Transcriptional regulator DT426_12785 ENOG4105XSJ toxin secretion phage lysis holin DT426_12885 ENOG410667J hydrolase DT426_12890 ENOG4105BZU Histidine kinase DT426_12895 ENOG4107RF6 penicillin-binding protein DT426_12920 ENOG4108JJB ABC transporter DT426_12935 ENOG4108HGU Histidine kinase DT426_13035 ENOG4105CB2 alcohol dehydrogenase DT426_13040 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase DT426_13045 ENOG4105CJN penicillin-binding protein DT426_13105 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DT426_13130 ENOG4107Y9U Membrane DT426_13150 ENOG4105EGD dinuclear metal center protein, YbgI family DT426_13155 ENOG4105M6F mutator MutT protein DT426_13170 ENOG4105FCD Major Facilitator DT426_13185 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DT426_13190 ENOG4108Z4K mutator MutT protein DT426_13215 ENOG4108XI2 Domain of unknown function (DUF1963) DT426_13240 ENOG4108NRW Phospholipase, patatin family DT426_13245 ENOG4105KWG Pfam:DUF1696 DT426_13270 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DT426_13280 ENOG4105PKS Excinuclease abc c subunit domain protein DT426_13315 ENOG41087PP glycosyltransferase MGT family DT426_13330 ENOG4107VFR oxidoreductase DT426_13355 ENOG4105U0R haloacid dehalogenase-like hydrolase DT426_13360 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DT426_13365 ENOG4105BZU Histidine kinase DT426_13385 ENOG4107WD8 ABC transporter, permease DT426_13400 ENOG4105DY8 decarboxylase DT426_13415 ENOG4108IUM Glycogen debranching enzyme DT426_13425 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic DT426_13445 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) DT426_13450 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DT426_13455 ENOG4105FDR Membrane DT426_13460 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DT426_13510 ENOG4105MSI germination protein ypeb DT426_13540 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) DT426_13545 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) DT426_13550 ENOG4107Z3H Transcriptional regulator, TetR family DT426_13585 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family DT426_13600 ENOG4105E98 transcriptional regulator DeoR family DT426_13615 ENOG41062ES Transcriptional regulator DT426_13635 ENOG4107QKR Dehydrogenase DT426_13645 ENOG4107RUY (E1 component), alpha subunit DT426_13655 ENOG4105E1F short-chain dehydrogenase reductase DT426_13685 ENOG4107SQ8 Glycine betaine DT426_13690 ENOG4108IJ7 Glycine betaine DT426_13700 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DT426_13715 ENOG4105E66 phosphoriboisomerase A DT426_13720 ENOG41082BV acetyltransferase DT426_13740 ENOG4108M1A Chitin-binding protein DT426_13755 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) DT426_13770 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DT426_13775 ENOG4105MSB protein, conserved in bacteria DT426_13800 ENOG4108Z7F N-acetyltransferase DT426_13825 ENOG4105KEG ribosomal-protein-alanine acetyltransferase DT426_13830 ENOG4105EEM helicase DT426_13840 ENOG41066HZ AIG2-like family DT426_13845 ENOG4105C9U ATP-dependent DNA helicase RecQ DT426_13895 ENOG4108M1A Chitin-binding protein DT426_13915 ENOG4105BZG amino acid carrier protein DT426_13920 ENOG4105C26 Dehydrogenase DT426_13925 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DT426_13935 ENOG4105CTU Proline racemase DT426_13940 ENOG41080HI glycine oxidase DT426_13950 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein DT426_13985 ENOG4107T5V SNARE associated Golgi DT426_13995 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD DT426_14010 ENOG4105DTQ mandelate racemase muconate lactonizing DT426_14025 ENOG4107SET aldo keto reductase DT426_14065 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DT426_14070 ENOG4105BZU Histidine kinase DT426_14075 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DT426_14100 ENOG4105DPN Oligoendopeptidase f DT426_14105 ENOG4105EPR degv family DT426_14165 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) DT426_14170 ENOG4106K7D Major facilitator family transporter DT426_14195 ENOG4107BMA Transglycosylase associated protein DT426_14210 ENOG41089UC methyltransferase, type 11 DT426_14245 ENOG4105CHM Aminotransferase DT426_14295 ENOG4105C02 permease DT426_14310 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DT426_14315 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein DT426_14320 ENOG4105D7T ABC transporter DT426_14345 ENOG4108AQF aminoglycoside N(3)-acetyltransferase DT426_14380 ENOG4107VC0 DNA alkylation repair enzyme DT426_14385 ENOG4105C6T cysteine synthase DT426_14390 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase DT426_14405 ENOG4107VMI polysaccharide deacetylase DT426_14425 ENOG4108ZCF integral membrane protein DT426_14430 ENOG4105E0M Sulfatase DT426_14435 ENOG4105C5H ABC transporter DT426_14440 ENOG4105EYF MMPL domain protein DT426_14445 ENOG41082JN Transcriptional regulator DT426_14470 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase DT426_14475 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase DT426_14520 ENOG41069ER domain protein DT426_14550 ENOG4105D4B ABC, transporter DT426_14560 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane DT426_14565 ENOG4105C2J ABC transporter DT426_14570 ENOG4105DKT Transcriptional regulator DT426_14575 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) DT426_14585 ENOG41061GT Aldolase DT426_14605 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) DT426_14635 ENOG4105II7 pyrroline-5-carboxylate reductase DT426_14645 ENOG4107258 Transcriptional regulator DT426_14670 ENOG4105ECK Fatty Acid Desaturase DT426_14680 ENOG4107RBI VanW family DT426_14685 ENOG4105G6Z alkaline phosphatase DT426_14695 ENOG4105VMP Transcriptional regulator DT426_14715 ENOG4105KNA -acetyltransferase DT426_14750 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DT426_14775 ENOG4105C8Y Acetylornithine aminotransferase DT426_14815 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DT426_14825 ENOG41090AA DT426_14830 ENOG4106BHF DT426_14875 ENOG4108IBT Inherit from COG: transposase DT426_14895 ENOG4108TVJ Nitroreductase DT426_14900 ENOG4105FS7 Transcriptional regulator DT426_14925 ENOG4105WEC Molybdate metabolism regulator DT426_14950 ENOG4108XET gCN5-related N-acetyltransferase DT426_14965 ENOG4108PCN EamA-like transporter family DT426_15010 ENOG410635A Membrane DT426_15020 ENOG4108IQI permease DT426_15075 ENOG4108VJ1 Transcriptional regulator (CarD family DT426_15085 ENOG4105BZU Histidine kinase DT426_15115 ENOG4107RF6 penicillin-binding protein DT426_15120 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) DT426_15150 ENOG4105P4J Allophanate hydrolase, subunit 1 DT426_15155 ENOG4107258 Transcriptional regulator DT426_15165 ENOG4106N3A copper homeostasis protein cutc DT426_15170 ENOG4108ZHR arsR family transcriptional regulator DT426_15180 ENOG4105FDT acyl-CoA dehydrogenase DT426_15195 ENOG4105DWD nucleoside recognition domain protein DT426_15235 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) DT426_15305 ENOG4105E2A Dehydrogenase DT426_15315 ENOG4108IJ0 Aspartate ammonia-lyase DT426_15320 ENOG4105HDK L-asparaginase DT426_15325 ENOG4108IMY Transcriptional regulator DT426_15345 ENOG4108B31 Spore germination protein DT426_15355 ENOG4105BZU Histidine kinase DT426_15380 ENOG41075H3 AraC family transcriptional regulator DT426_15395 ENOG4105YWU small acid-soluble spore protein DT426_15400 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) DT426_15405 ENOG4105CUB amino acid DT426_15410 ENOG4105II7 pyrroline-5-carboxylate reductase DT426_15415 ENOG4108NHD germination protein DT426_15420 ENOG4108Q8B Spore germination protein DT426_15455 ENOG4106A3M Cytochrome p-450 DT426_15475 ENOG4105CGH 5'-nucleotidase DT426_15485 ENOG4105CHJ isochorismatase hydrolase DT426_15510 ENOG41090MY MarR family Transcriptional regulator DT426_15525 ENOG4105VZ8 Transcriptional regulator DT426_15565 ENOG4105F6J Alpha beta hydrolase fold DT426_15580 ENOG4108606 TspO/MBR family DT426_15585 ENOG4105CVP deoxyribo-dipyrimidine photolyase DT426_15600 ENOG4108TWJ NADH dehydrogenase subunit 5 DT426_15605 ENOG4105GPN Uncharacterized conserved protein (DUF2294) DT426_15620 ENOG4105E1K spore germination protein DT426_15625 ENOG4107VMI polysaccharide deacetylase DT426_15630 ENOG4108U7W acetyltransferase DT426_15635 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase DT426_15640 ENOG4105DSE periplasmic solute binding protein DT426_15645 ENOG4105CC5 ABC transporter DT426_15650 ENOG4105DIK (ABC) transporter DT426_15675 ENOG4105D6J arsenicaL-resistance protein DT426_15680 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase DT426_15685 ENOG41085FC arsR family transcriptional regulator DT426_15735 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DT426_15740 ENOG41062D9 Histidine kinase DT426_15780 ENOG4105DNP FAD linked oxidase domain protein DT426_15795 ENOG4105C19 ABC transporter DT426_15830 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DT426_15835 ENOG4105C0R drug resistance transporter emrb qaca subfamily DT426_15850 ENOG4105K6H D-cysteine desulfhydrase DT426_15870 ENOG4105JQZ Methyltransferase DT426_15890 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) DT426_15910 ENOG4105BZU Histidine kinase DT426_15925 ENOG4108U05 Transcriptional regulator DT426_15930 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 DT426_15940 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) DT426_15955 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DT426_15975 ENOG4108JQ1 Dehydrogenase DT426_15980 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) DT426_15995 ENOG41082W1 Cupin 2, conserved barrel domain protein DT426_16005 ENOG410874W AraC family transcriptional regulator DT426_16025 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DT426_16035 ENOG4108IG5 Transcriptional regulator DT426_16150 ENOG4108VXD carboxy-peptidase DT426_16155 ENOG4105PNM synthesis protein DT426_16165 ENOG4108ISG Major Facilitator DT426_16180 ENOG4107MII Sugar-specific transcriptional regulator TrmB DT426_16185 ENOG4105CZM Major Facilitator DT426_16195 ENOG4105CRW Short chain fatty acid transporter DT426_16210 ENOG4105DYS nad(p)h dehydrogenase (quinone) DT426_16270 ENOG4108K8S endonuclease I DT426_16280 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) DT426_16285 ENOG4108Z66 YbaK ebsC protein DT426_16305 ENOG4105KVH Transcriptional regulator DT426_16310 ENOG4108RCM Nitroreductase DT426_16340 ENOG4108PSK reductase DT426_16405 ENOG4105C31 Tryptophanyl-tRNA synthetase DT426_16410 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) DT426_16450 ENOG4105EV4 Multidrug resistance protein mdtH DT426_16480 ENOG4105C37 (CBS) domain DT426_16505 ENOG4105DDN Pentapeptide repeat-containing protein DT426_16510 ENOG4105XDF Protein of unknown function (DUF1272) DT426_16515 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) DT426_16520 ENOG4105CMG Carbohydrate kinase DT426_16525 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DT426_16535 ENOG4105CV1 Transketolase (EC 2.2.1.1) DT426_16540 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase DT426_16560 ENOG4105C44 Serine transporter DT426_16600 ENOG4105KVH Transcriptional regulator DT426_16605 ENOG4108TZY GntR Family Transcriptional Regulator DT426_16610 ENOG4105D9R oxidoreductase DT426_16655 ENOG4105JAB phenazine biosynthesis protein, phzf family DT426_16670 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein DT426_16675 ENOG4105KVH Transcriptional regulator DT426_16680 ENOG4107SCK Monooxygenase DT426_16700 ENOG4108ZJ4 polysaccharide deacetylase DT426_16755 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) DT426_16790 ENOG4105H3G oxidoreductase DT426_16825 ENOG4105CIS alcohol dehydrogenase DT426_16865 ENOG4108TN2 lmbE family DT426_16875 ENOG4107R3E Citrate transporter DT426_16885 ENOG4105WCN acetyltransferase DT426_16890 ENOG4108MES Periplasmic binding protein DT426_16895 ENOG4105EHG Permease protein DT426_16900 ENOG4105DQ5 transport system permease protein DT426_16905 ENOG4105NX3 Membrane DT426_16925 ENOG4107CUJ Protein of unknown function (DUF2690) DT426_16935 ENOG4107V2S Transcriptional regulator DT426_16955 ENOG4105C98 muts2 protein DT426_16965 ENOG4105E5K Alpha-amylase DT426_16970 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase DT426_16975 ENOG4105DPN Oligoendopeptidase f DT426_16980 ENOG4108A04 Beta-lactamase DT426_16990 ENOG4105E5T Major Facilitator Superfamily DT426_17005 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DT426_17015 ENOG41082BM Transcriptional regulator, arsr family DT426_17020 ENOG4105CIS alcohol dehydrogenase DT426_17040 ENOG4105C09 Bile acid DT426_17045 ENOG4105CQB FAD linked oxidase domain protein DT426_17065 ENOG4105CEP NADH dehydrogenase DT426_17090 ENOG4105D2T synthase DT426_17105 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) DT426_17110 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DT426_17115 ENOG4105C1B dTDP-glucose 4-6-dehydratase DT426_17120 ENOG4105C5E polysaccharide biosynthesis protein DT426_17145 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C DT426_17150 ENOG4108M1A Chitin-binding protein DT426_17160 ENOG4105E1K spore germination protein DT426_17180 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase DT426_17195 ENOG4105FAW cDP-glucose 4,6-dehydratase DT426_17240 ENOG4105BZU Histidine kinase DT426_17250 ENOG4105C5H ABC transporter DT426_17255 ENOG41067SE Tetr family transcriptional regulator DT426_17260 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity DT426_17270 ENOG4108VXD carboxy-peptidase DT426_17275 ENOG4107DUR UPF0457 protein DT426_17295 ENOG4105BZU Histidine kinase DT426_17305 ENOG4105KT7 mgtC SapB transporter DT426_17315 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DT426_17320 ENOG41073R8 VanW family DT426_17330 ENOG4108R1P DT426_17345 ENOG4105VEQ Cold shock protein DT426_17365 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) DT426_17385 ENOG410904N short-chain dehydrogenase reductase DT426_17395 ENOG4106IQC argininosuccinate lyase DT426_17410 ENOG4108IA2 Sodium pantothenate symporter DT426_17420 ENOG4105C26 Dehydrogenase DT426_17425 ENOG4105CHR reductase DT426_17435 ENOG4105EWU Squalene--hopene cyclase DT426_17445 ENOG4105FR1 rard protein DT426_17450 ENOG410696E Membrane DT426_17465 ENOG4105D1F ATP-binding protein DT426_17475 ENOG4108ZAF Molybdopterin DT426_17480 ENOG4105CVM Molybdenum cofactor synthesis domain protein DT426_17485 ENOG4105D06 uba thif-type nad fad binding protein DT426_17490 ENOG4105TMB Formate nitrite transporter DT426_17500 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DT426_17505 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) DT426_17515 ENOG4108JB9 formate dehydrogenase DT426_17520 ENOG4105E1K spore germination protein DT426_17590 ENOG4107QJT sodium dicarboxylate symporter DT426_17595 ENOG4108KGH TRANSCRIPTIONal DT426_17605 ENOG4105EMN RNA polymerase sigma factor DT426_17615 ENOG4105CIG ABC transporter DT426_17635 ENOG4105D9R oxidoreductase DT426_17645 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DT426_17650 ENOG4105K4P CoA-binding domain protein DT426_17655 ENOG4105C0H protease DT426_17660 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DT426_17670 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase DT426_17675 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) DT426_17680 ENOG4105W8X HesB YadR YfhF-family protein DT426_17705 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DT426_17710 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DT426_17720 ENOG4108JJA ABC, transporter DT426_17725 ENOG4108I0Z Aconitate hydratase DT426_17755 ENOG4105E5W Transporter DT426_17765 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DT426_17785 ENOG4107F3J Amp-dependent synthetase and ligase DT426_17790 ENOG4107ZYJ bioY protein DT426_17795 ENOG4105CEY Amp-dependent synthetase and ligase DT426_17810 ENOG4108IMY Transcriptional regulator DT426_17845 ENOG4107AYK membrAne DT426_17860 ENOG4105BZU Histidine kinase DT426_17865 ENOG4105FBA Phospholipase Carboxylesterase DT426_17870 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase DT426_17875 ENOG4105CK7 Sodium proline symporter DT426_17885 ENOG4105CBC glutamate synthase DT426_17890 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DT426_17895 ENOG4108VJ1 Transcriptional regulator (CarD family DT426_17900 ENOG4108903 Formimidoylglutamase DT426_17960 ENOG4107QIV Cytochrome c biogenesis protein DT426_17975 ENOG4105CH2 amidohydrolase DT426_17985 ENOG4105CJ1 ABC, transporter DT426_18005 ENOG4107RSM transcriptional regulator DT426_18010 ENOG4105VAW lrga family DT426_18015 ENOG41067MG lrgb family DT426_18055 ENOG4105BZ1 (ABC) transporter DT426_18060 ENOG4105BZ1 (ABC) transporter DT426_18100 ENOG4105CGH 5'-nucleotidase DT426_18110 ENOG4108SVB resolvase DT426_18130 ENOG4105K7K Transcriptional regulator DT426_18135 ENOG4105C5F glutamine synthetase DT426_18140 ENOG4105KV4 Transcriptional regulator DT426_18145 ENOG4105CXI aluminum resistance protein DT426_18150 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DT426_18155 ENOG4105EN6 Membrane DT426_18160 ENOG4106F1P AAA ATPase, central domain protein DT426_18190 ENOG41069ER domain protein DT426_18195 ENOG4105DM4 PTS System DT426_18200 ENOG4105DE4 1-phosphofructokinase DT426_18205 ENOG4105E98 transcriptional regulator DeoR family DT426_18210 ENOG4107QW4 alcohol dehydrogenase DT426_18215 ENOG4108SJC Membrane DT426_18225 ENOG4105C85 amino acid DT426_18250 ENOG4105TMB Formate nitrite transporter DT426_18255 ENOG4105K70 DNA-binding protein DT426_18265 ENOG4105C59 p-type ATPase DT426_18270 ENOG410681U heavy metal transport detoxification protein DT426_18275 ENOG4105VPX protein, conserved in bacteria DT426_18295 ENOG4105NIV Esterase DT426_18300 ENOG4105E0A ABC, transporter DT426_18325 ENOG4105CGK Exodeoxyribonuclease III DT426_18335 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DT426_18340 ENOG4105D03 DNA-3-methyladenine glycosylase II DT426_18370 ENOG4105BZU Histidine kinase DT426_18390 ENOG4105C5E polysaccharide biosynthesis protein DT426_18410 ENOG41067MG lrgb family DT426_18435 ENOG4105C8Q Methyl-accepting chemotaxis DT426_18440 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C DT426_18450 ENOG4105F0V Cell wall hydrolase DT426_18465 ENOG4105E0M Sulfatase DT426_18470 ENOG410890F Dynamin family DT426_18515 ENOG4105CZV ABC transporter DT426_18520 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DT426_18550 ENOG4105NA0 Transcriptional regulator DT426_18565 ENOG4105C8Q Methyl-accepting chemotaxis DT426_18570 ENOG4107VMI polysaccharide deacetylase DT426_18585 ENOG4108IMY Transcriptional regulator DT426_18635 ENOG4105DQU oxidoreductase, subunit beta DT426_18640 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein DT426_18645 ENOG4108IGT Dipeptidase DT426_18650 ENOG4105MCT stage V sporulation protein S DT426_18655 ENOG4105D48 metallophosphoesterase DT426_18680 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase DT426_18695 ENOG4105XZV Protein of unknown function (DUF3243) DT426_18700 ENOG4108RKS Short-chain dehydrogenase reductase Sdr DT426_18720 ENOG4105UIB (ABC) transporter DT426_18725 ENOG4108JQ9 ABC transporter DT426_18730 ENOG4105DIH basic membrane DT426_18735 ENOG4105FDP GntR family transcriptional regulator DT426_18745 ENOG4105CNU cell division protein FtsK DT426_18755 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit DT426_18765 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DT426_18775 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DT426_18780 ENOG4108S0H Dipicolinic acid synthetase, b subunit DT426_18785 ENOG4108IBT Inherit from COG: transposase DT426_18905 ENOG4105CDU Replicative dna helicase DT426_18970 ENOG4105E35 Dipicolinate synthase subunit A DT426_18980 ENOG4105C1V Peptidase, M16 DT426_19000 ENOG4105DTN riboflavin biosynthesis protein ribF DT426_19015 ENOG4105W7A Protein of unknown function (DUF503) DT426_19025 ENOG4105VHM ribosomal protein DT426_19030 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination DT426_19035 ENOG4105CHV Transcription elongation factor NusA DT426_19045 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DT426_19055 ENOG4105DZP Membrane-associated zinc metalloprotease DT426_19060 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) DT426_19065 ENOG4105KNE Phosphatidate cytidylyltransferase DT426_19070 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) DT426_19080 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) DT426_19110 ENOG4108HE4 integrase family DT426_19120 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DT426_19125 ENOG4105C79 DNA protecting protein DprA DT426_19130 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha DT426_19145 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) DT426_19170 ENOG4105VB6 UPF0109 protein DT426_19190 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) DT426_19195 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) DT426_19210 ENOG4105CHR reductase DT426_19215 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DT426_19230 ENOG4105CB5 ATP-dependent DNA helicase recG DT426_19235 ENOG4105DP4 dak2 domain fusion protein ylov DT426_19240 ENOG4108ZAA Alkaline-shock protein DT426_19255 ENOG4105FJ0 thiamine DT426_19260 ENOG4105DJV ribulose-phosphate 3-epimerase DT426_19265 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) DT426_19270 ENOG4105D9P serine threonine protein kinase DT426_19275 ENOG4108ZF3 Phosphatase DT426_19285 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B DT426_19300 ENOG4105C25 Primosomal protein n' DT426_19305 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase DT426_19325 ENOG4105DSJ YicC domain protein DT426_19335 ENOG4105F23 Fibronectin-binding protein DT426_19425 ENOG4105C34 Pseudouridine synthase DT426_19440 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DT426_19450 ENOG4105DBK s4 domain protein DT426_19455 ENOG41067XK integral membrane protein DT426_19465 ENOG4105DFA alanine racemase domain protein DT426_19470 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase DT426_19475 ENOG4105WR5 sporulation protein, YlmC YmxH family DT426_19485 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DT426_19495 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) DT426_19500 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) DT426_19510 ENOG4105D4A Cell wall formation (By similarity) DT426_19515 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DT426_19520 ENOG4105CNI cell division protein FtsW DT426_19535 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) DT426_19540 ENOG4105CJN penicillin-binding protein DT426_19545 ENOG4105CJN penicillin-binding protein DT426_19585 ENOG4105KNH Nucleic acid-binding protein DT426_19595 ENOG41063PX domain protein DT426_19600 ENOG4105D78 K07001 NTE family protein DT426_19605 ENOG4105H20 Sporulation integral membrane protein YlbJ DT426_19615 ENOG4106H78 methyltransferase DT426_19635 ENOG4107TB6 phosphoglycerate mutase DT426_19650 ENOG4106UY4 Inherit from COG: Scp-like extracellular DT426_19700 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) DT426_19710 ENOG4105CNI cell division protein FtsW DT426_19725 ENOG4108IAB Phoh family DT426_19745 ENOG4105QA2 DT426_19750 ENOG4105CI3 gtp-binding protein typa DT426_19760 ENOG4105ECY inositol monophosphatase DT426_19780 ENOG4105CXN decarboxylase DT426_19830 ENOG4105CPP Dehydrogenase, E1 component DT426_19845 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DT426_19855 ENOG4108X4Q Hydrolase DT426_19870 ENOG4105CN5 Metallo-Beta-Lactamase DT426_19875 ENOG4107ZYR domain protein DT426_19910 ENOG4108XRC Protein of unknown function (DUF458) DT426_19915 ENOG4107IN1 Protein of unknown function (DUF1797) DT426_19930 ENOG4105EPM Diguanylate phosphodiesterase DT426_19935 ENOG4105K6S Short-chain dehydrogenase reductase Sdr DT426_19950 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) DT426_19960 ENOG4105UIN DT426_20015 ENOG4108HGU Histidine kinase DT426_20025 ENOG4105CHM Aminotransferase DT426_20030 ENOG4105FKQ transcriptional regulator DT426_20035 ENOG4105EG2 ABC transporter, permease DT426_20045 ENOG4107FKK extracellular solute-binding protein family 1 DT426_20055 ENOG4105CG3 alpha amylase, catalytic region DT426_20100 ENOG4105CHU acetyl-coa acetyltransferase DT426_20135 ENOG4105K7K Transcriptional regulator DT426_20140 ENOG4105DTD Dehydrogenase DT426_20160 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase DT426_20185 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) DT426_20200 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DT426_20210 ENOG4105BZU Histidine kinase DT426_20230 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) DT426_20245 ENOG4105CID antiterminator DT426_20255 ENOG4105FDP GntR family transcriptional regulator DT426_20265 ENOG4105CE4 GlcNAc 6-P deacetylase DT426_20305 ENOG4107ZE5 PPIases accelerate the folding of proteins DT426_20310 ENOG4105PTM secreted protein DT426_20315 ENOG4105J7I hydrolase DT426_20325 ENOG4105G6R Stage v sporulation protein ae DT426_20335 ENOG4105CZ3 stage V sporulation protein ad DT426_20340 ENOG41090VF Stage v sporulation protein ac DT426_20360 ENOG4105C8J )-transporter DT426_20365 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DT426_20375 ENOG41082AN stage II sporulation protein DT426_20380 ENOG4105DZ1 carboxypeptidase DT426_20390 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DT426_20395 ENOG4105DVE abc transporter atp-binding protein DT426_20435 ENOG4105D7N magnesium and cobalt transport protein CorA DT426_20460 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DT426_20470 ENOG4105I3K Ferric uptake regulator, Fur family DT426_20475 ENOG4105MZ9 stage II sporulation protein m DT426_20495 ENOG4105CPC Aldo Keto reductase DT426_20505 ENOG4105RHY Pfam:UPF0157 DT426_20525 ENOG4107SKW Inherit from COG: Alpha beta hydrolase DT426_20535 ENOG4105ETE Transcriptional regulator (LacI family DT426_20540 ENOG4108YM7 Gcn5-related n-acetyltransferase DT426_20560 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) DT426_20565 ENOG4108R6K riboflavin synthase, subunit alpha DT426_20590 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DT426_20595 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DT426_20610 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DT426_20620 ENOG4105DFD Na H antiporter DT426_20625 ENOG4105CGH 5'-nucleotidase DT426_20650 ENOG4105DBV ornithine carbamoyltransferase DT426_20665 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) DT426_20680 ENOG4108IXY short-chain dehydrogenase reductase DT426_20685 ENOG41069FQ Metallo-beta-lactamase superfamily DT426_20690 ENOG4105II7 pyrroline-5-carboxylate reductase DT426_20695 ENOG4105EJQ L-serine dehydratase DT426_20725 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic DT426_20740 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DT426_20745 ENOG4105D9U N-acetyltransferase DT426_20755 ENOG4108VZI ErfK ybiS ycfS ynhG family protein DT426_20760 ENOG4108QEG Membrane DT426_20765 ENOG4105CDA abc transporter atp-binding protein DT426_20770 ENOG4105E5Q amino acid AbC transporter DT426_20775 ENOG4108HW3 (ABC) transporter DT426_20790 ENOG4105G7B Protein of unknown function (DUF2992) DT426_20810 ENOG4105C7S Dehydrogenase DT426_20815 ENOG4105CPP Dehydrogenase, E1 component DT426_20835 ENOG4107RDP Dehydrogenase DT426_20850 ENOG4108JUB Transcriptional regulator DT426_20860 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DT426_20875 ENOG4107QQR Sporulation DT426_20975 ENOG4107QQR Sporulation DT426_20985 ENOG4105S1Z Stage IV sporulation protein B DT426_20990 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) DT426_20995 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) DT426_21000 ENOG4105DX0 Hemolysin A DT426_21010 ENOG4105CTB Polyprenyl synthetase DT426_21035 ENOG4108ZSR alkaline shock protein DT426_21040 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DT426_21065 ENOG410644B Stage III sporulation protein af DT426_21075 ENOG4105KQ4 Stage iii sporulation protein ad DT426_21080 ENOG4108CQH stage III sporulation protein AC DT426_21085 ENOG4105KR5 Stage iii sporulation protein DT426_21090 ENOG4105CD2 stage iii sporulation protein aa DT426_21115 ENOG4105DC7 peptidase M24 DT426_21130 ENOG4105CBJ Metal-dependent enzyme DT426_21140 ENOG4107YBY Hydrolase DT426_21170 ENOG41082GG biotin lipoate A B protein ligase DT426_21175 ENOG4105WZW rhodanese family DT426_21200 ENOG41080TC multidrug resistance protein DT426_21245 ENOG4105C0D helicase DT426_21330 ENOG4107R6U sodium dicarboxylate symporter DT426_21365 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DT426_21370 ENOG4105C3R Methionine synthase DT426_21380 ENOG4105C28 cystathionine DT426_21385 ENOG4105C28 cystathionine DT426_21405 ENOG4105C5X domain protein DT426_21415 ENOG4105DKQ ROK family DT426_21425 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase DT426_21440 ENOG4108UTW Plays a role in the regulation of phosphate uptake DT426_21445 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DT426_21450 ENOG4105C8U phosphate abc transporter DT426_21455 ENOG4105C8U phosphate abc transporter DT426_21465 ENOG4107RF6 penicillin-binding protein DT426_21475 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DT426_21500 ENOG4105N80 Ferric uptake regulator, Fur family DT426_21510 ENOG4105FDK ABC transporter DT426_21515 ENOG4108JYZ YitT family DT426_21520 ENOG41069ZM Protein of unknown function (DUF2624) DT426_21545 ENOG4105EGD dinuclear metal center protein, YbgI family DT426_21560 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DT426_21565 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) DT426_21590 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) DT426_21595 ENOG4105KG3 cytidine deaminase DT426_21600 ENOG4107YR5 Diacylglycerol kinase DT426_21610 ENOG4105CTJ Metal Dependent Phosphohydrolase DT426_21615 ENOG4105C9A Phoh family DT426_21625 ENOG41068P3 sporulation protein YqfC DT426_21635 ENOG4105KTH gatB Yqey DT426_21645 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DT426_21650 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) DT426_21680 ENOG4105CSA Coproporphyrinogen iii oxidase DT426_21685 ENOG4105KVH Transcriptional regulator DT426_21710 ENOG4105TQK DNA polymerase iii, delta' subunit DT426_21720 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 DT426_21725 ENOG4108UK2 deaminase DT426_21730 ENOG4105KQC Competence protein DT426_21740 ENOG4105DXX methyltransferase DT426_21750 ENOG4108WF2 Metal Dependent Phosphohydrolase DT426_21760 ENOG410812S Rna-binding protein DT426_21770 ENOG4105CQW ribosome biogenesis GTPase YqeH DT426_21775 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase DT426_21790 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DT426_21810 ENOG4108TVJ Nitroreductase DT426_21825 ENOG4105G6Z alkaline phosphatase DT426_21830 ENOG4105KEG ribosomal-protein-alanine acetyltransferase DT426_21835 ENOG4108MUZ hydrolase DT426_21870 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin DT426_21875 ENOG4105MIR Phenylalanine 4-monooxygenase DT426_21885 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DT426_21925 ENOG4105S6R Iron-hydroxamate transporter permease subunit DT426_21930 ENOG4108V5C ABC transporter DT426_21945 ENOG4108EKI Dehydrogenase DT426_21950 ENOG4105C28 cystathionine DT426_21980 ENOG4107XRG penicillin-binding protein DT426_21990 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) DT426_22000 ENOG4105CFP Peptidase U32 DT426_22005 ENOG4105XYU peptidase (U32 family) DT426_22010 ENOG4108VQJ O-methyltransferase DT426_22015 ENOG4105HHA aminodeoxychorismate lyase DT426_22035 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DT426_22045 ENOG4105C02 permease DT426_22060 ENOG41060CR DT426_22065 ENOG4105C7H Helicase, RecD TraA family DT426_22075 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) DT426_22080 ENOG4105C3J Cysteine desulfurase DT426_22090 ENOG4105D1H recombination factor protein RarA DT426_22095 ENOG4108VCI transcription factor, rsfa family DT426_22100 ENOG4105CUZ uba thif-type nad fad binding protein DT426_22115 ENOG4105CUT histidyl-tRNA synthetase DT426_22130 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DT426_22140 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) DT426_22145 ENOG41076HS cation diffusion facilitator family transporter DT426_22150 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DT426_22160 ENOG4105CKP Polysaccharide Biosynthesis Protein DT426_22165 ENOG4108QG2 Membrane DT426_22175 ENOG4105VIE preprotein translocase, subunit YajC DT426_22190 ENOG41061AI Protein of unknown function (DUF2905) DT426_22205 ENOG4108HUF Transporter DT426_22235 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase DT426_22240 ENOG4108IYU L-aspartate oxidase DT426_22255 ENOG4108RPX mosc domain containing protein DT426_22265 ENOG4105CQC Prephenate dehydratase DT426_22280 ENOG4105C19 ABC transporter DT426_22285 ENOG4105EWM Histidine kinase DT426_22310 ENOG4105X36 (ribosomal) protein DT426_22320 ENOG4105C03 ribonuclease DT426_22335 ENOG4107QMS site-determining protein DT426_22350 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) DT426_22355 ENOG4105DFF Rod shape-determining protein mreb DT426_22375 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase DT426_22380 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) DT426_22390 ENOG41068KH stage VI sporulation protein D DT426_22400 ENOG4105D52 delta-aminolevulinic acid dehydratase DT426_22425 ENOG4105K56 Transcriptional regulator DT426_22445 ENOG4108IUQ atp-dependent protease DT426_22470 ENOG4108QCI YvbH-like oligomerisation region DT426_22490 ENOG4105M59 Phosphodiesterase, mj0936 family DT426_22505 ENOG4108XJQ germination protein DT426_22515 ENOG4108PCX Major Facilitator DT426_22525 ENOG4105KBX Transcriptional regulator, TetR family DT426_22535 ENOG4105PFC Transcriptional regulator DT426_22545 ENOG4105DZC cytosine deaminase DT426_22550 ENOG41067S9 phage shock protein C, PspC DT426_22555 ENOG4108JCI Transcriptional regulator DT426_22565 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) DT426_22570 ENOG4108Z40 Transcriptional regulator DT426_22575 ENOG4105RHA ABC transporter, permease DT426_22580 ENOG4108IUX (ABC) transporter DT426_22585 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family DT426_22590 ENOG4105ER2 Ompa motb domain protein DT426_22595 ENOG4105E14 MotA TolQ exbB proton channel DT426_22600 ENOG4108VXD carboxy-peptidase DT426_22610 ENOG4105E33 succinate dehydrogenase DT426_22620 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit DT426_22635 ENOG4105K63 Thioredoxin DT426_22640 ENOG4105C10 Electron transfer flavoprotein DT426_22645 ENOG4105BZJ Electron transfer flavoprotein DT426_22650 ENOG41060WC Enoyl-CoA hydratase DT426_22655 ENOG4107Z3H Transcriptional regulator, TetR family DT426_22660 ENOG4105CEY Amp-dependent synthetase and ligase DT426_22670 ENOG4105J76 Periplasmic binding protein DT426_22675 ENOG4105S6R Iron-hydroxamate transporter permease subunit DT426_22710 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DT426_22720 ENOG4105DR4 Methyltransferase DT426_22730 ENOG4105KFN sortase, SrtB family DT426_22735 ENOG4105E0A ABC, transporter DT426_22750 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) DT426_22760 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) DT426_22770 ENOG4105FE9 pseudouridine synthase DT426_22780 ENOG4105DCG PHP domain protein DT426_22795 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DT426_22810 ENOG4105C5S asparaginyl-tRNA synthetase DT426_22815 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) DT426_22825 ENOG4108RWN rrna methyltransferase DT426_22850 ENOG4105C0R drug resistance transporter emrb qaca subfamily DT426_22855 ENOG4105CW7 secretion protein, HlyD family DT426_22860 ENOG4108JGH Tetr family transcriptional regulator DT426_22865 ENOG4105CN9 Peptidase m42 family protein DT426_22885 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) DT426_22890 ENOG4105C22 threonyL-tRNA synthetase DT426_22895 ENOG4108TDW sporulation protein YtxC DT426_22920 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) DT426_22925 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DT426_22930 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) DT426_22940 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) DT426_22945 ENOG4105C2M dna polymerase I DT426_22950 ENOG4105BZU Histidine kinase DT426_22955 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DT426_22975 ENOG4108HMX isocitrate dehydrogenase (NADP) DT426_22980 ENOG4105BZN citrate synthase DT426_23000 ENOG4108REF Sporulation integral membrane protein ytvi DT426_23005 ENOG4105FS0 cytoplasmic membrane protein DT426_23030 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DT426_23035 ENOG4105C6K Malic enzyme DT426_23040 ENOG4105C0B DNA polymerase III (alpha subunit) DT426_23045 ENOG4105VV2 DT426_23055 ENOG4105SFS phosphoesterase RecJ domain protein DT426_23080 ENOG4105DC7 peptidase M24 DT426_23125 ENOG4105Z7P Acetyltransferase (GNAT) family DT426_23130 ENOG41082W1 Cupin 2, conserved barrel domain protein DT426_23150 ENOG4107YZX Universal stress protein DT426_23190 ENOG4108JYZ YitT family DT426_23210 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) DT426_23220 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) DT426_23225 ENOG4105KBJ sporulation protein ytfj DT426_23240 ENOG4105EFZ amidohydrolase DT426_23250 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DT426_23275 ENOG4106KR7 LysR family Transcriptional regulator DT426_23285 ENOG4105U5Y Transcriptional regulator DT426_23295 ENOG4105C28 cystathionine DT426_23305 ENOG4108IBT Inherit from COG: transposase DT426_23335 ENOG4105EMN RNA polymerase sigma factor DT426_23345 ENOG4108UW5 maltose o-acetyltransferase DT426_23355 ENOG4105F1V Acetoin utilization protein DT426_23360 ENOG4105W87 Cbs domain DT426_23365 ENOG4105DGU Histone deacetylase DT426_23380 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DT426_23385 ENOG4105BZU Histidine kinase DT426_23390 ENOG4107SNB ankyrin repeat protein YahD DT426_23395 ENOG4105EP9 oxidoreductase DT426_23425 ENOG4105ETE Transcriptional regulator (LacI family DT426_23435 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase DT426_23440 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase DT426_23460 ENOG4105C88 aminopeptidase DT426_23480 ENOG4108IPJ Membrane DT426_23515 ENOG4108VDD TRNA binding domain protein DT426_23545 ENOG4105C8F Beta-lactamase domain protein DT426_23560 ENOG4108V15 phosphotransferase enzyme family DT426_23565 ENOG4108IUM Glycogen debranching enzyme DT426_23575 ENOG4107QSE Dipeptidase DT426_23580 ENOG4105YW5 deoR family transcriptional regulator DT426_23595 ENOG4105CBX hi0933 family DT426_23635 ENOG4108VJ1 Transcriptional regulator (CarD family DT426_23640 ENOG4107EXU Short-chain dehydrogenase reductase Sdr DT426_23645 ENOG4105CSC Glucose uptake protein DT426_23660 ENOG4108ZAF Molybdopterin DT426_23665 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein DT426_23670 ENOG4105CVM Molybdenum cofactor synthesis domain protein DT426_23680 ENOG4105D06 uba thif-type nad fad binding protein DT426_23685 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DT426_23710 ENOG41085GJ domain protein DT426_23720 ENOG4105DWV Homoserine O-trans-acetylase DT426_23730 ENOG4108B31 Spore germination protein DT426_23760 ENOG410605W Major Facilitator DT426_23765 ENOG4107S91 Sodium hydrogen exchanger DT426_23770 ENOG4105NCW Trka-c domain protein DT426_23785 ENOG4105C19 ABC transporter DT426_23805 ENOG4105N5T Radical SAM Protein DT426_23835 ENOG4105E8V Alpha Beta Hydrolase Fold protein DT426_23840 ENOG4108Z0R Transferase DT426_23845 ENOG4105YVM Phosphoesterase, PA-phosphatase related DT426_23850 ENOG4105BZF Glycosyl transferase (Group 1 DT426_23860 ENOG4105EPU Molybdenum cofactor synthesis domain protein DT426_23945 ENOG4105BZU Histidine kinase DT426_23950 ENOG4105BZU Histidine kinase DT426_23955 ENOG4105CH6 catalase DT426_23960 ENOG4107S9D Alpha beta hydrolase DT426_23965 ENOG4107T7U Sulfatase DT426_23990 ENOG4105D2X ABC transporter substrate-binding protein DT426_24000 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component DT426_24060 ENOG41080TC multidrug resistance protein DT426_24065 ENOG410839T multidrug resistance protein DT426_24085 ENOG4108V2W Carbonate dehydratase DT426_24090 ENOG4105C4M (Ubiquinol oxidase) subunit I DT426_24095 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DT426_24140 ENOG41087YS Phage shock protein A DT426_24165 ENOG4105N67 Proton-coupled thiamine transporter YuaJ DT426_24170 ENOG4105BZU Histidine kinase DT426_24175 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DT426_24200 ENOG4108UGV hypoxanthine phosphoribosyltransferase DT426_24205 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) DT426_24260 ENOG4107ZTW SNARE associated Golgi DT426_24275 ENOG4105C19 ABC transporter DT426_24280 ENOG41086D8 Transcriptional regulator DT426_24290 ENOG4105CJ1 ABC, transporter DT426_24300 ENOG41082BM Transcriptional regulator, arsr family DT426_24345 ENOG4105C6Z Gluconate DT426_24350 ENOG4105FDP GntR family transcriptional regulator DT426_24370 ENOG41069H0 dihydroorotase EC 3.5.2.3 DT426_24395 ENOG4105DTQ mandelate racemase muconate lactonizing DT426_24405 ENOG4108IPT Naphthoate synthase DT426_24410 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) DT426_24420 ENOG4105E4F Isochorismate synthase DT426_24425 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase DT426_24435 ENOG4105VEQ Cold shock protein DT426_24470 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) DT426_24495 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DT426_24500 ENOG4108Q5F Tetr family transcriptional regulator DT426_24635 ENOG4105KT7 mgtC SapB transporter DT426_24640 ENOG4107PBV potassium channel DT426_24660 ENOG4105WG9 Conserved Protein DT426_24670 ENOG4105CHM Aminotransferase DT426_24675 ENOG4108ZB6 transcriptional regulator AsnC family DT426_24680 ENOG4105C5I Dehydrogenase DT426_24685 ENOG4108MUZ hydrolase DT426_24695 ENOG4105C87 Aminotransferase class I and II DT426_24705 ENOG4105Y38 Kinase-associated protein B DT426_24715 ENOG4107R3E Citrate transporter DT426_24730 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) DT426_24735 ENOG4105KA0 thioesterase Superfamily protein DT426_24750 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DT426_24770 ENOG41069ER domain protein DT426_24785 ENOG4105CEP NADH dehydrogenase DT426_24815 ENOG4105EWC Purine nucleoside phosphorylase DT426_24845 ENOG4108YX9 iron--sulfur cluster insertion protein erpA DT426_24870 ENOG4108JJA ABC, transporter DT426_24875 ENOG4105C4B ABC transporter, permease DT426_24880 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA DT426_24910 ENOG41083MR nifu domain-containing protein DT426_24925 ENOG4108W5N phosphatidylglycerophosphatase a DT426_24945 ENOG4105DAX Pfam:DUF2983 DT426_24955 ENOG4105DYS nad(p)h dehydrogenase (quinone) DT426_24960 ENOG4105D4U had-superfamily hydrolase, subfamily iia DT426_24975 ENOG4105CBT Fructose-1,6-bisphosphatase DT426_24995 ENOG4105MMD transcriptional regulator DT426_25000 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) DT426_25005 ENOG4107TXC Transcriptional regulator DT426_25010 ENOG41090T1 Membrane DT426_25035 ENOG4105FAA peptidase M23 DT426_25040 ENOG4108YTE sporulation protein YunB DT426_25045 ENOG4105KZD Domain of unknown function (DUF1805) DT426_25050 ENOG4107R8B 5'-nucleotidase DT426_25055 ENOG4105DIW FeS assembly protein SUFB DT426_25060 ENOG4108UNV SUF system FeS assembly protein, NifU family DT426_25065 ENOG4105C9B Cysteine desulfurase DT426_25070 ENOG4105JRK feS assembly protein SufD DT426_25075 ENOG4105C3K feS assembly ATPase SufC DT426_25080 ENOG4105D01 (LipO)protein DT426_25085 ENOG4105D01 (LipO)protein DT426_25090 ENOG4108UMI ABC transporter, permease DT426_25095 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DT426_25120 ENOG41080E8 Transcriptional regulator, Spx MgsR family DT426_25140 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DT426_25165 ENOG4108W8B Beta-lactamase domain protein DT426_25170 ENOG4105C1G acyl-Coa dehydrogenase DT426_25175 ENOG4105CHU acetyl-coa acetyltransferase DT426_25190 ENOG4105DZ1 carboxypeptidase DT426_25210 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DT426_25225 ENOG4108SUT Major Facilitator Superfamily DT426_25230 ENOG4107R7I amino acid DT426_25245 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DT426_25255 ENOG4107AYK membrAne DT426_25305 ENOG4107ZTW SNARE associated Golgi DT426_25315 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein DT426_25320 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DT426_25325 ENOG4105BZU Histidine kinase DT426_25350 ENOG4105C8Q Methyl-accepting chemotaxis DT426_25355 ENOG4105C8Q Methyl-accepting chemotaxis DT426_25360 ENOG4105VG1 fes assembly suf system protein DT426_25365 ENOG4105D4Y metalloprotease DT426_25370 ENOG4105C2I pirin domain protein DT426_25385 ENOG4107T5V SNARE associated Golgi DT426_25390 ENOG4107S91 Sodium hydrogen exchanger DT426_25395 ENOG4105NCW Trka-c domain protein DT426_25405 ENOG4108RMU ferritin dps family protein DT426_25425 ENOG4108URH decarboxylase DT426_25440 ENOG4105DHF Membrane DT426_25445 ENOG4105D9N nucleoside DT426_25455 ENOG4105D9N nucleoside DT426_25470 ENOG4108RYK Nad-dependent epimerase dehydratase DT426_25485 ENOG4105CV8 reductase DT426_25490 ENOG4105F27 Major Facilitator DT426_25495 ENOG4105KVH Transcriptional regulator DT426_25510 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DT426_25515 ENOG4105D4A Cell wall formation (By similarity) DT426_25525 ENOG4105C8Q Methyl-accepting chemotaxis DT426_25540 ENOG4105WMR Protein CrcB homolog DT426_25560 ENOG4105C5H ABC transporter DT426_25565 ENOG4108MK9 spermidine N(1)-acetyltransferase DT426_25575 ENOG4108VY7 phosphate-starvation-inducible protein PsiE DT426_25585 ENOG4108W2Y isochorismatase DT426_25605 ENOG4108V2W Carbonate dehydratase DT426_25610 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) DT426_25625 ENOG4108IPW abc transporter atp-binding protein DT426_25630 ENOG4105CM4 permease protein DT426_25650 ENOG4107UNZ domain protein DT426_25705 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) DT426_25715 ENOG4105XZU Preprotein translocase, subunit SecG DT426_25720 ENOG41067MG lrgb family DT426_25770 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DT426_25780 ENOG4105RHA ABC transporter, permease DT426_25785 ENOG4108IUX (ABC) transporter DT426_25790 ENOG4105BZU Histidine kinase DT426_25795 ENOG4108W5X Transcriptional Regulator, LuxR family DT426_25845 ENOG41090VF Stage v sporulation protein ac DT426_25850 ENOG4105CZ3 stage V sporulation protein ad DT426_25865 ENOG4108QY0 Membrane DT426_25870 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DT426_25875 ENOG4105KRI phosphocarrier protein (HPr DT426_25885 ENOG4105CHW UPF0052 protein DT426_25895 ENOG4108Z4K mutator MutT protein DT426_25905 ENOG4105C3M thioredoxin reductase DT426_25915 ENOG4108S4C acetyltransferase DT426_25935 ENOG41086DT Membrane protein of unknown function DT426_25945 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DT426_25965 ENOG4107TXC Transcriptional regulator DT426_25980 ENOG4105HMI Membrane DT426_25985 ENOG4105DUM transcriptional regulator, lysR family DT426_25995 ENOG4108WS4 fmn reductase DT426_26010 ENOG4105BZ1 (ABC) transporter DT426_26020 ENOG4105CN1 protease DT426_26025 ENOG4105CRP Part of the ABC transporter FtsEX involved in DT426_26030 ENOG4105CAK Cell division ATP-binding protein ftsE DT426_26055 ENOG4108RDQ ABC transporter DT426_26085 ENOG4105MS2 ribosomal subunit Interface protein DT426_26090 ENOG4105VEQ Cold shock protein DT426_26095 ENOG41081UC Inherit from COG: Competence protein DT426_26110 ENOG4105KVH Transcriptional regulator DT426_26120 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein DT426_26125 ENOG4108KGH TRANSCRIPTIONal DT426_26130 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DT426_26135 ENOG4105C6Y Udp-glucose 6-dehydrogenase DT426_26140 ENOG4105ESV Glycosyl transferase, family 4 DT426_26150 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DT426_26170 ENOG4105F8D glycoside hydrolase family 4 DT426_26175 ENOG4105VCP PTS System DT426_26180 ENOG4105CK1 PTS System DT426_26190 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) DT426_26195 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) DT426_26200 ENOG4105VCP PTS System DT426_26210 ENOG4105VZJ PTS System DT426_26230 ENOG4105ECB domain protein DT426_26235 ENOG4107RSM transcriptional regulator DT426_26265 ENOG4105DAA L-lactate DT426_26275 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) DT426_26290 ENOG4105E0M Sulfatase DT426_26315 ENOG4107R8N Glycosyl transferase, family 2 DT426_26320 ENOG4105C94 Transporter DT426_26330 ENOG41069ER domain protein DT426_26355 ENOG4105KBK Zinc finger, swim domain protein DT426_26360 ENOG4105C0D helicase DT426_26390 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DT426_26400 ENOG4107RBB ABC transporter, permease DT426_26405 ENOG4105C19 ABC transporter DT426_26425 ENOG4105CXY transporter DT426_26440 ENOG4105BZU Histidine kinase DT426_26445 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DT426_26455 ENOG4108KGH TRANSCRIPTIONal DT426_26460 ENOG4105CMR udp-glucose 4-epimerase DT426_26465 ENOG4105C6Y Udp-glucose 6-dehydrogenase DT426_26495 ENOG4105D3Q Sugar transferase DT426_26500 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DT426_26505 ENOG4108RB3 Capsular polysaccharide biosynthesis protein DT426_26510 ENOG4107YJ4 chain length determinant protein DT426_26515 ENOG4105HTX biosynthesis protein DT426_26520 ENOG4107YJ4 chain length determinant protein DT426_26535 ENOG4105MT0 Sporulation transcriptional regulator spoiiid DT426_26545 ENOG4105FRN stage II sporulation protein DT426_26560 ENOG4105DY9 regulatoR DT426_26580 ENOG4106778 Protein of unknown function (DUF1146) DT426_26585 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DT426_26590 ENOG4105C8S subunit m DT426_26595 ENOG4105D65 subunit l DT426_26620 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DT426_26625 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain DT426_26635 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain DT426_26640 ENOG4105BZU Histidine kinase DT426_26690 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) DT426_26695 ENOG41062M3 atp synthase DT426_26720 ENOG4108UIC UPF0340 protein DT426_26725 ENOG4108YZG isomerase DT426_26740 ENOG4108VGI doxx family DT426_26745 ENOG4107XC4 flavin reductase domain protein, FMN-binding DT426_26760 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DT426_26770 ENOG4108ZXQ stage ii sporulation protein r DT426_26775 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DT426_26780 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) DT426_26795 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) DT426_26800 ENOG4105CBT Fructose-1,6-bisphosphatase DT426_26805 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DT426_26845 ENOG4105C1G acyl-Coa dehydrogenase DT426_26850 ENOG4105C1G acyl-Coa dehydrogenase DT426_26855 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DT426_26865 ENOG4105DF6 Fe-S oxidoreductase DT426_26880 ENOG4105BZU Histidine kinase DT426_26895 ENOG4105D4Y metalloprotease DT426_26905 ENOG4105BZU Histidine kinase DT426_26910 ENOG4105KCT ABC transporter DT426_26915 ENOG4108M15 ABC transporter DT426_26920 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) DT426_26930 ENOG4105IIU Aminopeptidase DT426_26950 ENOG4105EMN RNA polymerase sigma factor DT426_26960 ENOG410684U Domain of unknown function (DUF1934) DT426_26980 ENOG4105CYW agmatinase DT426_26990 ENOG4105DXB Major Facilitator superfamily DT426_26995 ENOG4107SWG transcriptional regulator MERR family DT426_27000 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DT426_27005 ENOG4105BZ4 penicillin-binding protein DT426_27010 ENOG4108XFG YwhD family DT426_27015 ENOG4108Z4T Peptidase M50 DT426_27020 ENOG41069HH 4-oxalocrotonate tautomerase DT426_27025 ENOG4105DCI Phosphohydrolase DT426_27030 ENOG4108MES Periplasmic binding protein DT426_27035 ENOG4105E0A ABC, transporter DT426_27040 ENOG4105EHG Permease protein DT426_27045 ENOG4105DQ5 transport system permease protein DT426_27055 ENOG4108VCI transcription factor, rsfa family DT426_27060 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) DT426_27065 ENOG4108IJ2 phosphate acetyltransferase DT426_27070 ENOG4107UEZ chlorite dismutase DT426_27085 ENOG4108VKI Cell wall hydrolase DT426_27105 ENOG4107SVH Potassium channel protein DT426_27115 ENOG410667J hydrolase DT426_27120 ENOG4105VCH membrane DT426_27130 ENOG4108TU7 Inherit from COG: (ABC) transporter DT426_27135 ENOG4105CJ1 ABC, transporter DT426_27140 ENOG41090WU lipolytic protein G-D-S-L family DT426_27155 ENOG4105D6E homoserine dehydrogenase DT426_27175 ENOG4108Y4K DNA-binding transcriptional activator DT426_27185 ENOG4105WH1 Two component transcriptional regulator luxr family DT426_27190 ENOG4105BZU Histidine kinase DT426_27195 ENOG4105DWF phosphomethylpyrimidine kinase DT426_27200 ENOG4105BZU Histidine kinase DT426_27210 ENOG4105VCD cytoplasmic protein DT426_27215 ENOG4105D22 carbon starvation protein DT426_27220 ENOG4105DY9 regulatoR DT426_27225 ENOG41079KZ Major Facilitator Superfamily DT426_27240 ENOG4105CG5 Glycosyl transferase (Group 1 DT426_27250 ENOG4105EN6 Membrane DT426_27255 ENOG4106YBV Methyl-accepting chemotaxis DT426_27265 ENOG4108S4H thioesterase Superfamily protein DT426_27270 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) DT426_27285 ENOG4105K64 Glycosyl transferase, family 2 DT426_27295 ENOG4105EJV Membrane DT426_27300 ENOG4105CKK Glycosyl transferase, family 2 DT426_27310 ENOG4108IG5 Transcriptional regulator DT426_27315 ENOG4105C5H ABC transporter DT426_27320 ENOG41067SE Tetr family transcriptional regulator DT426_27330 ENOG4105E0X reductase DT426_27335 ENOG4106F5Q Membrane DT426_27350 ENOG4108NEV two component transcriptional regulator, LytTR family DT426_27355 ENOG4108HRK Histidine kinase DT426_27360 ENOG4107RGD Major Facilitator superfamily DT426_27380 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DT426_27390 ENOG4105IW1 AmiS UreI transporter DT426_27405 ENOG4105CMR udp-glucose 4-epimerase DT426_27410 ENOG4108UT2 hemolysin iii DT426_27420 ENOG4105C1J atp-dependent rna helicase DT426_27425 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) DT426_27430 ENOG4105DPN Oligoendopeptidase f DT426_27500 ENOG4107Y5K Resolvase DT426_27550 ENOG4105C0H protease DT426_27555 ENOG4105Q2H domain protein DT426_27570 ENOG4105BZU Histidine kinase DT426_27575 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DT426_27600 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis DT426_27605 ENOG4105CDU Replicative dna helicase DT426_27615 ENOG4105BZR domain protein DT426_27620 ENOG4108XMW Membrane DT426_27630 ENOG4108UUM single-stranded DNA-binding protein DT426_27640 ENOG4105C3G gtp-binding protein DT426_27645 ENOG4105VDK protein, conserved in bacteria DT426_27650 ENOG4105D8X mechanosensitive ion channel DT426_27655 ENOG4108ZDA Sporulation protein YyaC DT426_27660 ENOG4105FA0 parb-like partition protein DT426_27665 ENOG4107QJE Chromosome Partitioning Protein DT426_27685 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) DT426_27695 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DT426_27715 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DT426_27720 ENOG410848D S4 domain protein YaaA DT426_27735 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DT426_27770 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DT426_27805 ENOG4105ZMH deoxynucleoside kinase DT426_27815 ENOG4105GTG Isochorismatase DT426_27825 ENOG4108Z6B deaminase DT426_27835 ENOG4105C6E dna polymerase iii DT426_27855 ENOG41067KS pro-sigma K processing DT426_27890 ENOG4105CXN decarboxylase DT426_27900 ENOG4105FA2 dna polymerase iii DT426_27905 ENOG4105MA4 psp1 domain protein DT426_27915 ENOG41060K3 Methyltransferase DT426_27925 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) DT426_27930 ENOG4105KRN Transcriptional regulator, abrb family DT426_27935 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) DT426_27940 ENOG4105F8V Hydrolase, tatD family DT426_27945 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) DT426_27955 ENOG4105XFA sporulation peptidase YabG DT426_27960 ENOG4105W42 Veg protein DT426_27975 ENOG4105DFT pur operon repressor DT426_27980 ENOG4105KME endoribonuclease L-psp DT426_27995 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DT426_28000 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) DT426_28010 ENOG4108JA2 transcriptioN-repair coupling factor DT426_28015 ENOG4108M14 stage v sporulation protein t DT426_28025 ENOG4108IY2 MazG family DT426_28030 ENOG41082I2 s4 domain protein DT426_28035 ENOG4105VYY sporulation protein yabp DT426_28050 ENOG41060GV RNA binding s1 domain protein DT426_28070 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) DT426_28075 ENOG4108UGV hypoxanthine phosphoribosyltransferase DT426_28080 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) DT426_28095 ENOG4105C6T cysteine synthase DT426_28100 ENOG4105CRQ synthase (Component I) DT426_28105 ENOG4105DDQ anthranilate synthase DT426_28110 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 DT426_28115 ENOG4105EEI dihydropteroate synthase DT426_28120 ENOG4105KRF dihydroneopterin aldolase DT426_28125 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase DT426_28135 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)