locus-tag	class	description
HLK66_00010	COG0592	DNA-directed DNA polymerase activity
HLK66_00015	COG2501	S4 domain
HLK66_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HLK66_00030	COG0187	DNA topoisomerase II activity
HLK66_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HLK66_00040	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HLK66_00075	COG0516	GMP reductase activity
HLK66_00075	COG0517	IMP dehydrogenase activity
HLK66_00090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HLK66_00105	COG1428	Deoxynucleoside kinase
HLK66_00110	COG1428	Deoxynucleoside kinase
HLK66_00115	COG0352	thiamine-phosphate diphosphorylase activity
HLK66_00125	COG2104	thiamine diphosphate biosynthetic process
HLK66_00130	COG2022	thiamine diphosphate biosynthetic process
HLK66_00135	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HLK66_00140	COG3858	chitin binding
HLK66_00140	COG1388	LysM domain
HLK66_00145	COG1335	isochorismatase
HLK66_00150	COG0590	tRNA wobble adenosine to inosine editing
HLK66_00160	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HLK66_00165	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HLK66_00170	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HLK66_00215	COG1982	Orn Lys Arg decarboxylase major
HLK66_00225	COG3870	Protein conserved in bacteria
HLK66_00230	COG1728	Protein conserved in bacteria
HLK66_00235	COG0470	DNA polymerase III
HLK66_00240	COG1774	PSP1 C-terminal conserved region
HLK66_00245	COG4467	Involved in initiation control of chromosome replication
HLK66_00250	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HLK66_00255	COG2827	Endonuclease containing a URI domain
HLK66_00260	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HLK66_00265	COG2002	toxin-antitoxin pair type II binding
HLK66_00275	COG0084	hydrolase, TatD family'
HLK66_00280	COG3584	3D domain protein
HLK66_00280	COG3583	domain protein
HLK66_00290	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HLK66_00300	COG4466	Protein conserved in bacteria
HLK66_00310	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HLK66_00315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HLK66_00320	COG0251	oxidation-reduction process
HLK66_00325	COG2088	sporulation resulting in formation of a cellular spore
HLK66_00330	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HLK66_00335	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HLK66_00340	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HLK66_00355	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HLK66_00360	COG2002	toxin-antitoxin pair type II binding
HLK66_00365	COG2188	Transcriptional regulator
HLK66_00375	COG2244	polysaccharide biosynthetic process
HLK66_00380	COG3956	TIGRFAM MazG family protein
HLK66_00385	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HLK66_00400	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HLK66_00405	COG1098	S1 RNA binding domain
HLK66_00415	COG2208	phosphoserine phosphatase activity
HLK66_00420	COG2304	oxidoreductase activity
HLK66_00425	COG0515	serine threonine protein kinase
HLK66_00430	COG0037	tRNA processing
HLK66_00445	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HLK66_00450	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HLK66_00455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HLK66_00460	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HLK66_00465	COG0512	Glutamine amidotransferase of anthranilate synthase
HLK66_00470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HLK66_00475	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HLK66_00480	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HLK66_00485	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HLK66_00490	COG1396	sequence-specific DNA binding
HLK66_00495	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HLK66_00500	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HLK66_00585	COG3880	PFAM UvrB UvrC protein
HLK66_00590	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HLK66_00595	COG0542	response to heat
HLK66_00600	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HLK66_00605	COG4956	integral membrane protein (PIN domain superfamily)
HLK66_00610	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HLK66_00615	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HLK66_00620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HLK66_00625	COG1045	serine acetyltransferase
HLK66_00630	COG0215	cysteine-tRNA ligase activity
HLK66_00640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLK66_00645	COG3688	RNA-binding protein containing a PIN domain
HLK66_00655	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HLK66_00660	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HLK66_00665	COG0250	Participates in transcription elongation, termination and antitermination
HLK66_00670	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HLK66_00675	COG0081	regulation of translation
HLK66_00680	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HLK66_00685	COG0222	ribosome binding
HLK66_00690	COG2813	Specifically methylates the guanine in position
HLK66_00700	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HLK66_00705	COG1358	cellular component organization or biogenesis
HLK66_00710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HLK66_00715	COG0049	tRNA binding
HLK66_00725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HLK66_00730	COG0051	transcription antitermination factor activity, RNA binding
HLK66_00735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HLK66_00740	COG0088	Forms part of the polypeptide exit tunnel
HLK66_00750	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HLK66_00755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HLK66_00770	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HLK66_00775	COG0255	Belongs to the universal ribosomal protein uL29 family
HLK66_00780	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HLK66_00810	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HLK66_00815	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HLK66_00820	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HLK66_00825	COG1841	ribosomal large subunit assembly
HLK66_00835	COG0201	protein transport
HLK66_00840	COG0563	adenylate kinase activity
HLK66_00845	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HLK66_00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HLK66_00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HLK66_00865	COG0202	RNA polymerase activity
HLK66_00870	COG0203	ribosomal protein L17
HLK66_00875	COG1122	ATPase activity
HLK66_00880	COG1122	ATPase activity
HLK66_00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HLK66_00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HLK66_00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HLK66_00955	COG2723	6-phospho-beta-galactosidase activity
HLK66_00960	COG2190	(PTS) system
HLK66_00960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_00960	COG1263	PTS System
HLK66_00970	COG2190	(PTS) system
HLK66_01010	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLK66_01015	COG0489	protein tyrosine kinase activity
HLK66_01025	COG0726	polysaccharide deacetylase
HLK66_01100	COG1595	DNA-templated transcription, initiation
HLK66_01105	COG5662	AntiSigma factor
HLK66_01110	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HLK66_01115	COG4856	YbbR-like protein
HLK66_01120	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLK66_01125	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HLK66_01150	COG1846	Transcriptional regulator
HLK66_01165	COG0778	Nitroreductase
HLK66_01180	COG0745	RESPONSE REGULATOR receiver
HLK66_01185	COG2205	protein histidine kinase activity
HLK66_01210	COG0745	RESPONSE REGULATOR receiver
HLK66_01215	COG0642	Histidine kinase
HLK66_01235	COG1733	regulation of RNA biosynthetic process
HLK66_01245	COG1012	belongs to the aldehyde dehydrogenase family
HLK66_01255	COG1063	alcohol dehydrogenase
HLK66_01260	COG3730	PTS system glucitol sorbitol-specific
HLK66_01265	COG3732	PTS system glucitol sorbitol-specific
HLK66_01280	COG0656	L-ascorbic acid biosynthetic process
HLK66_01290	COG2188	Transcriptional regulator
HLK66_01295	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_01295	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_01300	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_01300	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_01310	COG3716	PTS system mannose fructose sorbose family IID component
HLK66_01315	COG2807	transmembrane transport
HLK66_01320	COG3344	reverse transcriptase
HLK66_01325	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_01340	COG2807	transmembrane transport
HLK66_01350	COG4607	ABC-type enterochelin transport system periplasmic component
HLK66_01355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLK66_01360	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLK66_01365	COG1120	ATPase activity
HLK66_01370	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLK66_01380	COG0730	response to heat
HLK66_01395	COG2210	Belongs to the sulfur carrier protein TusA family
HLK66_01405	COG1114	Component of the transport system for branched-chain amino acids
HLK66_01410	COG2378	regulation of single-species biofilm formation
HLK66_01420	COG0519	Catalyzes the synthesis of GMP from XMP
HLK66_01425	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HLK66_01435	COG1595	DNA-templated transcription, initiation
HLK66_01440	COG0492	ferredoxin-NADP+ reductase activity
HLK66_01445	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HLK66_01455	COG0456	acetyltransferase
HLK66_01480	COG1595	DNA-templated transcription, initiation
HLK66_01490	COG1316	TRANSCRIPTIONal
HLK66_01500	COG0454	-acetyltransferase
HLK66_01525	COG1011	Hydrolase
HLK66_01535	COG1609	Transcriptional regulator
HLK66_01540	COG2182	Extracellular solute-binding protein
HLK66_01545	COG1175	transmembrane transport
HLK66_01550	COG3833	ABC-type maltose transport systems, permease component
HLK66_01555	COG1874	Beta-galactosidase
HLK66_01570	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLK66_01575	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HLK66_01580	COG0583	DNA-binding transcription factor activity
HLK66_01595	COG0175	sulfate reduction
HLK66_01600	COG0306	phosphate transporter
HLK66_01605	COG2046	Belongs to the sulfate adenylyltransferase family
HLK66_01610	COG0529	Catalyzes the synthesis of activated sulfate
HLK66_01635	COG2205	protein histidine kinase activity
HLK66_01635	COG0784	Response regulator, receiver
HLK66_01640	COG5002	protein histidine kinase activity
HLK66_01655	COG0604	alcohol dehydrogenase
HLK66_01660	COG2404	hydrolase activity, acting on ester bonds
HLK66_01675	COG1657	PFAM Prenyltransferase squalene oxidase
HLK66_01680	COG0017	Asparaginyl-tRNA synthetase
HLK66_01685	COG3386	PFAM SMP-30 Gluconolaconase
HLK66_01695	COG0659	secondary active sulfate transmembrane transporter activity
HLK66_01705	COG3620	sequence-specific DNA binding
HLK66_01715	COG2190	(PTS) system
HLK66_01715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_01715	COG1263	PTS System
HLK66_01740	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLK66_01755	COG3328	transposase activity
HLK66_01765	COG4149	molybdate abc transporter
HLK66_01770	COG0725	ABC transporter, periplasmic molybdate-binding protein
HLK66_01775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLK66_01810	COG1252	NADH dehydrogenase
HLK66_01825	COG1122	ATPase activity
HLK66_01845	COG2244	polysaccharide biosynthetic process
HLK66_01850	COG0297	glycogen (starch) synthase activity
HLK66_01850	COG0438	transferase activity, transferring glycosyl groups
HLK66_01855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HLK66_01860	COG3307	-O-antigen
HLK66_01865	COG3206	protein involved in exopolysaccharide biosynthesis
HLK66_01870	COG1215	transferase activity, transferring glycosyl groups
HLK66_01875	COG0438	transferase activity, transferring glycosyl groups
HLK66_01880	COG1959	2 iron, 2 sulfur cluster binding
HLK66_01900	COG2362	D-Aminopeptidase
HLK66_01905	COG0601	transmembrane transport
HLK66_01910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLK66_01915	COG0444	Belongs to the ABC transporter superfamily
HLK66_01920	COG4166	transmembrane transport
HLK66_01925	COG1619	proteins homologs of microcin C7 resistance protein MccF
HLK66_01930	COG4948	Mandelate Racemase Muconate Lactonizing
HLK66_01935	COG0791	NLP P60 protein
HLK66_01940	COG4608	Belongs to the ABC transporter superfamily
HLK66_01950	COG1120	ATPase activity
HLK66_01965	COG0667	Aldo Keto reductase
HLK66_01970	COG0129	dihydroxy-acid dehydratase activity
HLK66_01975	COG0628	permease
HLK66_01980	COG0789	Transcriptional regulator
HLK66_01985	COG1253	flavin adenine dinucleotide binding
HLK66_01995	COG3711	transcriptional antiterminator
HLK66_02000	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_02005	COG0246	Mannitol dehydrogenase
HLK66_02010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLK66_02020	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HLK66_02035	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLK66_02040	COG4605	iron ion homeostasis
HLK66_02045	COG4604	ABC transporter, ATP-binding protein
HLK66_02050	COG4607	ABC-type enterochelin transport system periplasmic component
HLK66_02055	COG0673	inositol 2-dehydrogenase activity
HLK66_02060	COG1940	carbohydrate kinase activity
HLK66_02065	COG3850	Histidine kinase
HLK66_02065	COG5002	protein histidine kinase activity
HLK66_02070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLK66_02075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLK66_02105	COG1176	ABC-type spermidine putrescine transport system, permease component I
HLK66_02110	COG1177	transmembrane transport
HLK66_02115	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HLK66_02120	COG2861	carbohydrate metabolic process
HLK66_02125	COG0668	transmembrane transport
HLK66_02130	COG0569	domain protein
HLK66_02135	COG0783	Belongs to the Dps family
HLK66_02140	COG0772	Belongs to the SEDS family
HLK66_02145	COG2239	Acts as a magnesium transporter
HLK66_02150	COG0402	S-adenosylhomocysteine deaminase activity
HLK66_02160	COG1489	DNA binding
HLK66_02165	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLK66_02175	COG1120	ATPase activity
HLK66_02180	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HLK66_02195	COG1492	cobalamin metabolic process
HLK66_02200	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HLK66_02205	COG0588	phosphoglycerate mutase activity
HLK66_02210	COG2096	Adenosyltransferase
HLK66_02230	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HLK66_02240	COG0513	Belongs to the DEAD box helicase family
HLK66_02245	COG3402	PFAM membrane-flanked domain
HLK66_02250	COG3428	Bacterial PH domain
HLK66_02255	COG0705	Rhomboid family
HLK66_02260	COG0736	holo-[acyl-carrier-protein] synthase activity
HLK66_02265	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HLK66_02275	COG0864	Transcriptional regulator
HLK66_02280	COG2337	Toxic component of a toxin-antitoxin (TA) module
HLK66_02285	COG1366	Belongs to the anti-sigma-factor antagonist family
HLK66_02290	COG2172	sigma factor antagonist activity
HLK66_02295	COG2208	phosphoserine phosphatase activity
HLK66_02300	COG1366	Belongs to the anti-sigma-factor antagonist family
HLK66_02305	COG2172	sigma factor antagonist activity
HLK66_02310	COG1191	sigma factor activity
HLK66_02315	COG2208	phosphoserine phosphatase activity
HLK66_02320	COG2183	response to ionizing radiation
HLK66_02330	COG3091	SprT-like family
HLK66_02410	COG0802	atpase or kinase
HLK66_02415	COG1214	PFAM Peptidase M22, glycoprotease
HLK66_02420	COG0456	acetyltransferase
HLK66_02430	COG0488	(ABC) transporter
HLK66_02435	COG0315	cyclic pyranopterin monophosphate synthase activity
HLK66_02440	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HLK66_02450	COG1266	CAAX protease self-immunity
HLK66_02455	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HLK66_02460	COG0459	protein refolding
HLK66_02470	COG0346	lactoylglutathione lyase activity
HLK66_02500	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLK66_02505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_02505	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLK66_02505	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLK66_02515	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HLK66_02520	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HLK66_02535	COG3715	PTS system
HLK66_02540	COG3716	PTS system mannose fructose sorbose family IID component
HLK66_02545	COG0673	inositol 2-dehydrogenase activity
HLK66_02550	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HLK66_02555	COG0277	FAD linked oxidase domain protein
HLK66_02570	COG0840	transmembrane signaling receptor activity
HLK66_02575	COG0733	neurotransmitter:sodium symporter activity
HLK66_02590	COG4565	transcriptional regulatory protein
HLK66_02610	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HLK66_02615	COG1840	ABC-type Fe3 transport system, periplasmic component
HLK66_02625	COG3842	ATPase activity
HLK66_02635	COG1533	DNA photolyase activity
HLK66_02645	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HLK66_02650	COG3871	stress protein (general stress protein 26)
HLK66_02655	COG4294	response to UV
HLK66_02660	COG4294	response to UV
HLK66_02670	COG2211	Major facilitator Superfamily
HLK66_02680	COG0583	DNA-binding transcription factor activity
HLK66_02685	COG1473	amidohydrolase
HLK66_02690	COG1288	antiporter activity
HLK66_02700	COG0702	epimerase
HLK66_02705	COG2188	Transcriptional regulator
HLK66_02710	COG2222	sugar isomerase
HLK66_02715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLK66_02720	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HLK66_02750	COG1312	Catalyzes the dehydration of D-mannonate
HLK66_02760	COG1904	glucuronate isomerase
HLK66_02770	COG2190	(PTS) system
HLK66_02770	COG1263	PTS System
HLK66_02770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_02775	COG2723	6-phospho-beta-galactosidase activity
HLK66_02780	COG3711	transcriptional antiterminator
HLK66_02790	COG2310	stress, protein
HLK66_02795	COG0714	Associated with various cellular activities
HLK66_02800	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HLK66_02805	COG1305	Transglutaminase-like
HLK66_02810	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HLK66_02810	COG0519	Catalyzes the synthesis of GMP from XMP
HLK66_02815	COG0730	response to heat
HLK66_02820	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HLK66_02825	COG0517	IMP dehydrogenase activity
HLK66_02830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HLK66_02830	COG0574	Belongs to the PEP-utilizing enzyme family
HLK66_02835	COG2252	PERMEase
HLK66_02840	COG3711	transcriptional antiterminator
HLK66_02845	COG1263	PTS System
HLK66_02845	COG2190	(PTS) system
HLK66_02845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_02865	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HLK66_02910	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HLK66_02920	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HLK66_02925	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HLK66_02930	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HLK66_02935	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HLK66_02940	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HLK66_02945	COG0047	phosphoribosylformylglycinamidine synthase activity
HLK66_02955	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HLK66_02960	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HLK66_02965	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HLK66_02970	COG0138	bifunctional purine biosynthesis protein purh
HLK66_02975	COG0151	Belongs to the GarS family
HLK66_02980	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_02995	COG1470	cell adhesion involved in biofilm formation
HLK66_03000	COG4496	protein, YerC YecD
HLK66_03005	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HLK66_03010	COG0210	DNA helicase
HLK66_03015	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HLK66_03020	COG4851	CamS sex pheromone cAM373 precursor
HLK66_03025	COG5506	Protein of unknown function (DUF1694)
HLK66_03030	COG1764	response to oxidative stress
HLK66_03035	COG1846	Transcriptional regulator
HLK66_03045	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HLK66_03055	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HLK66_03075	COG1595	DNA-templated transcription, initiation
HLK66_03095	COG1597	lipid kinase activity
HLK66_03120	COG3173	Aminoglycoside phosphotransferase
HLK66_03150	COG2226	methyltransferase
HLK66_03165	COG0500	methyltransferase
HLK66_03180	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HLK66_03185	COG0210	DNA helicase
HLK66_03205	COG2814	Major facilitator Superfamily
HLK66_03210	COG0604	alcohol dehydrogenase
HLK66_03220	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HLK66_03225	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
HLK66_03230	COG2205	protein histidine kinase activity
HLK66_03240	COG0456	acetyltransferase
HLK66_03245	COG1388	LysM domain
HLK66_03245	COG3584	3D domain protein
HLK66_03265	COG2972	Histidine kinase
HLK66_03290	COG0166	Belongs to the GPI family
HLK66_03295	COG1733	regulation of RNA biosynthetic process
HLK66_03300	COG2514	catechol 2,3-dioxygenase activity
HLK66_03305	COG1366	Belongs to the anti-sigma-factor antagonist family
HLK66_03315	COG1785	Belongs to the alkaline phosphatase family
HLK66_03320	COG1794	racemase activity, acting on amino acids and derivatives
HLK66_03325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLK66_03330	COG3480	Lon protease (S16) C-terminal proteolytic domain
HLK66_03340	COG3279	Response regulator of the LytR AlgR family
HLK66_03360	COG1695	Transcriptional regulator
HLK66_03400	COG1132	(ABC) transporter
HLK66_03415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HLK66_03425	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HLK66_03435	COG2814	Major facilitator Superfamily
HLK66_03440	COG0527	aspartate kinase activity
HLK66_03450	COG0765	amino acid transport
HLK66_03455	COG1126	abc transporter atp-binding protein
HLK66_03465	COG1473	amidohydrolase
HLK66_03470	COG1473	amidohydrolase
HLK66_03475	COG0444	Belongs to the ABC transporter superfamily
HLK66_03480	COG4608	Belongs to the ABC transporter superfamily
HLK66_03485	COG0601	transmembrane transport
HLK66_03490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLK66_03500	COG1132	(ABC) transporter
HLK66_03505	COG1132	(ABC) transporter
HLK66_03510	COG2357	RelA SpoT domain protein
HLK66_03515	COG0513	Belongs to the DEAD box helicase family
HLK66_03530	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HLK66_03535	COG0697	spore germination
HLK66_03570	COG2197	response regulator
HLK66_03575	COG2244	polysaccharide biosynthetic process
HLK66_03590	COG0598	Magnesium transport protein CorA
HLK66_03595	COG1607	acyl-coa hydrolase
HLK66_03605	COG0670	Belongs to the BI1 family
HLK66_03610	COG1970	mechanosensitive ion channel activity
HLK66_03615	COG1254	Belongs to the acylphosphatase family
HLK66_03625	COG2309	aminopeptidase activity
HLK66_03630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLK66_03635	COG0551	DNA topoisomerase type I activity
HLK66_03635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HLK66_03650	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HLK66_03655	COG1360	Flagellar Motor Protein
HLK66_03665	COG1522	sequence-specific DNA binding
HLK66_03665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLK66_03670	COG2313	pseudouridylate synthase activity
HLK66_03675	COG1396	sequence-specific DNA binding
HLK66_03690	COG1396	sequence-specific DNA binding
HLK66_03695	COG2188	Transcriptional regulator
HLK66_03705	COG0024	Methionine aminopeptidase
HLK66_03710	COG4840	Belongs to the UPF0435 family
HLK66_03715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HLK66_03725	COG1295	ribonuclease BN
HLK66_03730	COG2217	Heavy metal translocating P-type atpase
HLK66_03735	COG0477	Major facilitator Superfamily
HLK66_03740	COG0387	Pfam Sodium calcium exchanger
HLK66_03745	COG2364	Membrane
HLK66_03755	COG0535	radical SAM domain protein
HLK66_03770	COG1309	transcriptional regulator
HLK66_03790	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HLK66_03795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLK66_03805	COG1959	2 iron, 2 sulfur cluster binding
HLK66_03825	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HLK66_03830	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HLK66_03890	COG0210	DNA helicase
HLK66_03915	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HLK66_03950	COG4842	Belongs to the WXG100 family
HLK66_03955	COG5417	Belongs to the EsaB family
HLK66_03960	COG4499	WXG100 protein secretion system (Wss), protein YukC
HLK66_03965	COG0433	COG0433 Predicted ATPase
HLK66_03965	COG1674	ftsk spoiiie
HLK66_03970	COG1511	domain protein
HLK66_03980	COG0488	(ABC) transporter
HLK66_03985	COG3940	Belongs to the glycosyl hydrolase 43 family
HLK66_03995	COG0737	Belongs to the 5'-nucleotidase family
HLK66_04000	COG0366	Alpha amylase catalytic
HLK66_04000	COG1874	Beta-galactosidase
HLK66_04015	COG2205	protein histidine kinase activity
HLK66_04015	COG0784	Response regulator, receiver
HLK66_04040	COG4191	Histidine kinase
HLK66_04060	COG4807	Protein conserved in bacteria
HLK66_04070	COG0583	DNA-binding transcription factor activity
HLK66_04095	COG0517	IMP dehydrogenase activity
HLK66_04095	COG1125	glycine betaine transport
HLK66_04100	COG1174	glycine betaine transport
HLK66_04120	COG0573	inorganic phosphate transmembrane transporter activity
HLK66_04125	COG0581	inorganic phosphate transmembrane transporter activity
HLK66_04130	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HLK66_04150	COG4753	response regulator
HLK66_04150	COG2207	Transcriptional regulator
HLK66_04155	COG4213	ABC transporter substrate-binding protein
HLK66_04160	COG1129	ABC transporter
HLK66_04165	COG4214	carbohydrate transport
HLK66_04170	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HLK66_04175	COG2211	Major facilitator Superfamily
HLK66_04195	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HLK66_04205	COG0702	epimerase
HLK66_04210	COG1733	regulation of RNA biosynthetic process
HLK66_04220	COG0765	amino acid transport
HLK66_04235	COG1619	proteins homologs of microcin C7 resistance protein MccF
HLK66_04240	COG0322	excinuclease ABC activity
HLK66_04260	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HLK66_04265	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HLK66_04270	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HLK66_04275	COG4260	virion core protein, lumpy skin disease virus
HLK66_04310	COG3534	alpha-L-arabinofuranosidase
HLK66_04315	COG1780	Probably involved in ribonucleotide reductase function
HLK66_04320	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLK66_04325	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLK66_04330	COG1595	DNA-templated transcription, initiation
HLK66_04345	COG1132	(ABC) transporter
HLK66_04350	COG1132	(ABC) transporter
HLK66_04375	COG0840	transmembrane signaling receptor activity
HLK66_04400	COG3275	phosphorelay sensor kinase activity
HLK66_04405	COG3279	Response regulator of the LytR AlgR family
HLK66_04410	COG2223	nitrite transmembrane transporter activity
HLK66_04415	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HLK66_04420	COG3853	Toxic anion resistance protein (TelA)
HLK66_04425	COG0384	phenazine biosynthesis protein PhzF
HLK66_04430	COG4708	membrane
HLK66_04440	COG1136	(ABC) transporter
HLK66_04445	COG0577	efflux transmembrane transporter activity
HLK66_04445	COG1136	(ABC) transporter
HLK66_04455	COG3850	Histidine kinase
HLK66_04455	COG5002	protein histidine kinase activity
HLK66_04460	COG1607	acyl-coa hydrolase
HLK66_04470	COG0683	leucine binding
HLK66_04495	COG2706	6-phosphogluconolactonase activity
HLK66_04500	COG3507	Belongs to the glycosyl hydrolase 43 family
HLK66_04510	COG2137	regulation of response to DNA damage stimulus
HLK66_04530	COG1988	membrane-bound metal-dependent
HLK66_04535	COG1194	a g-specific adenine glycosylase
HLK66_04545	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_04565	COG1132	(ABC) transporter
HLK66_04570	COG4129	membrane
HLK66_04575	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HLK66_04585	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HLK66_04590	COG0735	belongs to the Fur family
HLK66_04795	COG0398	Pfam SNARE associated Golgi protein
HLK66_04800	COG0745	RESPONSE REGULATOR receiver
HLK66_04805	COG0642	Histidine kinase
HLK66_04805	COG5002	protein histidine kinase activity
HLK66_04820	COG1132	(ABC) transporter
HLK66_04830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLK66_04840	COG1447	Phosphotransferase system cellobiose-specific component IIA
HLK66_04855	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLK66_04860	COG2723	6-phospho-beta-galactosidase activity
HLK66_04865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_04865	COG3711	transcriptional antiterminator
HLK66_04920	COG1304	FMN binding
HLK66_04930	COG1846	Transcriptional regulator
HLK66_04945	COG0477	Major facilitator Superfamily
HLK66_04950	COG3443	Belongs to the bacterial solute-binding protein 9 family
HLK66_04955	COG0803	Belongs to the bacterial solute-binding protein 9 family
HLK66_04955	COG0803	Belongs to the bacterial solute-binding protein 9 family
HLK66_04975	COG0456	acetyltransferase
HLK66_04975	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HLK66_04980	COG0789	Transcriptional regulator
HLK66_04985	COG0697	spore germination
HLK66_04995	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLK66_05000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLK66_05005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLK66_05015	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HLK66_05025	COG0745	RESPONSE REGULATOR receiver
HLK66_05030	COG2205	protein histidine kinase activity
HLK66_05035	COG1136	(ABC) transporter
HLK66_05045	COG1902	pentaerythritol trinitrate reductase activity
HLK66_05050	COG3711	transcriptional antiterminator
HLK66_05055	COG2190	(PTS) system
HLK66_05055	COG1263	PTS System
HLK66_05055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_05060	COG2723	6-phospho-beta-galactosidase activity
HLK66_05065	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HLK66_05070	COG1984	allophanate hydrolase subunit 2
HLK66_05075	COG2814	Major facilitator Superfamily
HLK66_05095	COG1349	DNA-binding transcription factor activity
HLK66_05100	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HLK66_05110	COG1132	(ABC) transporter
HLK66_05115	COG0641	radical SAM
HLK66_05125	COG2723	6-phospho-beta-galactosidase activity
HLK66_05155	COG2205	protein histidine kinase activity
HLK66_05160	COG2205	protein histidine kinase activity
HLK66_05180	COG1846	Transcriptional regulator
HLK66_05185	COG0346	lactoylglutathione lyase activity
HLK66_05190	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLK66_05195	COG0346	lactoylglutathione lyase activity
HLK66_05200	COG0400	carboxylic ester hydrolase activity
HLK66_05215	COG2391	methyltransferase activity
HLK66_05230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLK66_05235	COG0431	NADPH-dependent FMN reductase
HLK66_05250	COG2972	Histidine kinase
HLK66_05255	COG2207	Transcriptional regulator
HLK66_05255	COG4753	response regulator
HLK66_05260	COG3344	reverse transcriptase
HLK66_05265	COG0477	Major facilitator Superfamily
HLK66_05265	COG2814	Major facilitator Superfamily
HLK66_05270	COG3328	transposase activity
HLK66_05280	COG0741	lytic transglycosylase activity
HLK66_05285	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HLK66_05300	COG4221	oxidoreductase activity
HLK66_05305	COG0789	Transcriptional regulator
HLK66_05335	COG0586	Pfam SNARE associated Golgi protein
HLK66_05350	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HLK66_05365	COG1063	alcohol dehydrogenase
HLK66_05380	COG2116	formate transmembrane transporter activity
HLK66_05395	COG3382	B3 4 domain protein
HLK66_05400	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HLK66_05415	COG0778	Nitroreductase
HLK66_05420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HLK66_05425	COG2766	serine protein kinase
HLK66_05460	COG2832	Protein of unknown function (DUF454)
HLK66_05475	COG0667	Aldo Keto reductase
HLK66_05485	COG1737	Transcriptional regulator
HLK66_05490	COG2723	6-phospho-beta-galactosidase activity
HLK66_05495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_05495	COG2190	(PTS) system
HLK66_05495	COG1263	PTS System
HLK66_05500	COG0641	radical SAM
HLK66_05520	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HLK66_05530	COG4977	sequence-specific DNA binding
HLK66_05530	COG1917	Cupin 2, conserved barrel domain protein
HLK66_05535	COG1263	PTS System
HLK66_05535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_05590	COG0346	lactoylglutathione lyase activity
HLK66_05595	COG1733	regulation of RNA biosynthetic process
HLK66_05600	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_05620	COG2329	Antibiotic biosynthesis monooxygenase
HLK66_05625	COG1917	Cupin 2, conserved barrel domain protein
HLK66_05625	COG2207	Transcriptional regulator
HLK66_05630	COG0697	spore germination
HLK66_05635	COG2315	Protein conserved in bacteria
HLK66_05640	COG2207	Transcriptional regulator
HLK66_05645	COG2211	Major facilitator Superfamily
HLK66_05650	COG3250	beta-galactosidase activity
HLK66_05660	COG1312	Catalyzes the dehydration of D-mannonate
HLK66_05665	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_05670	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HLK66_05680	COG2197	response regulator
HLK66_05685	COG4585	Histidine kinase
HLK66_05690	COG3239	Fatty acid desaturase
HLK66_05695	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HLK66_05705	COG1396	sequence-specific DNA binding
HLK66_05720	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HLK66_05745	COG0745	RESPONSE REGULATOR receiver
HLK66_05750	COG5002	protein histidine kinase activity
HLK66_05755	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLK66_05760	COG0306	phosphate transporter
HLK66_05765	COG1392	Phosphate transport regulator
HLK66_05775	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_05780	COG0656	L-ascorbic acid biosynthetic process
HLK66_05785	COG2261	transglycosylase associated protein
HLK66_05790	COG0564	pseudouridine synthase activity
HLK66_05800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLK66_05810	COG3153	acetyltransferase
HLK66_05810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HLK66_05835	COG2252	PERMEase
HLK66_05850	COG0583	DNA-binding transcription factor activity
HLK66_05855	COG1309	transcriptional regulator
HLK66_05860	COG2076	Multidrug Resistance protein
HLK66_05885	COG2378	regulation of single-species biofilm formation
HLK66_05945	COG1694	Mazg nucleotide pyrophosphohydrolase
HLK66_05955	COG0789	Transcriptional regulator
HLK66_05955	COG4978	Transcriptional regulator
HLK66_05960	COG1811	Na channel or pump
HLK66_05965	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HLK66_05970	COG1131	(ABC) transporter
HLK66_05980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLK66_05985	COG0598	Magnesium transport protein CorA
HLK66_05990	COG0745	RESPONSE REGULATOR receiver
HLK66_05995	COG1253	flavin adenine dinucleotide binding
HLK66_06000	COG1253	flavin adenine dinucleotide binding
HLK66_06005	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLK66_06010	COG5278	phosphoserine phosphatase activity
HLK66_06010	COG0840	transmembrane signaling receptor activity
HLK66_06025	COG2814	Major facilitator Superfamily
HLK66_06035	COG1132	(ABC) transporter
HLK66_06040	COG1132	(ABC) transporter
HLK66_06045	COG2819	hydrolase of the alpha beta superfamily
HLK66_06050	COG2207	Transcriptional regulator
HLK66_06050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLK66_06055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLK66_06060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLK66_06075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLK66_06080	COG2819	hydrolase of the alpha beta superfamily
HLK66_06095	COG3842	ATPase activity
HLK66_06100	COG2508	Transcriptional regulator
HLK66_06125	COG0189	ligase activity
HLK66_06130	COG0189	ligase activity
HLK66_06135	COG0189	ligase activity
HLK66_06155	COG0561	phosphatase activity
HLK66_06160	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HLK66_06165	COG2252	PERMEase
HLK66_06170	COG4152	abc transporter atp-binding protein
HLK66_06175	COG1668	transmembrane transport
HLK66_06180	COG0420	3'-5' exonuclease activity
HLK66_06185	COG4717	serine-type aminopeptidase activity
HLK66_06220	COG1846	Transcriptional regulator
HLK66_06230	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HLK66_06235	COG0537	adenosine 5'-monophosphoramidase activity
HLK66_06240	COG1131	(ABC) transporter
HLK66_06245	COG4473	ABC transporter
HLK66_06255	COG1473	amidohydrolase
HLK66_06265	COG3069	C4-dicarboxylate transmembrane transporter activity
HLK66_06275	COG4585	Histidine kinase
HLK66_06280	COG2197	response regulator
HLK66_06290	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HLK66_06300	COG1309	transcriptional regulator
HLK66_06305	COG1511	domain protein
HLK66_06310	COG0095	Lipoate-protein ligase
HLK66_06315	COG0501	Belongs to the peptidase M48B family
HLK66_06345	COG0823	Involved in the tonB-independent uptake of proteins
HLK66_06345	COG1506	peptidase
HLK66_06345	COG4946	Tricorn protease homolog
HLK66_06355	COG0398	Pfam SNARE associated Golgi protein
HLK66_06410	COG0179	Fumarylacetoacetate (FAA) hydrolase
HLK66_06420	COG4585	Histidine kinase
HLK66_06425	COG2197	response regulator
HLK66_06430	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLK66_06435	COG1253	flavin adenine dinucleotide binding
HLK66_06440	COG1131	(ABC) transporter
HLK66_06455	COG2226	methyltransferase
HLK66_06460	COG1131	(ABC) transporter
HLK66_06470	COG1737	Transcriptional regulator
HLK66_06475	COG0673	inositol 2-dehydrogenase activity
HLK66_06480	COG0673	inositol 2-dehydrogenase activity
HLK66_06490	COG0662	Cupin 2, conserved barrel domain protein
HLK66_06490	COG2207	Transcriptional regulator
HLK66_06505	COG1247	-acetyltransferase
HLK66_06515	COG0367	asparagine synthase
HLK66_06520	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HLK66_06525	COG0697	spore germination
HLK66_06535	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_06540	COG1666	GTP binding
HLK66_06550	COG2996	Protein conserved in bacteria
HLK66_06560	COG1307	EDD domain protein, DegV family
HLK66_06565	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLK66_06585	COG0561	phosphatase activity
HLK66_06590	COG1073	alpha beta
HLK66_06595	COG2151	metal-sulfur cluster biosynthetic enzyme
HLK66_06600	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HLK66_06605	COG0303	'Molybdopterin
HLK66_06610	COG1620	l-lactate permease
HLK66_06615	COG2186	Transcriptional regulator
HLK66_06620	COG0247	lactate metabolic process
HLK66_06625	COG1139	Iron-sulfur cluster binding protein
HLK66_06630	COG1556	Lactate utilization protein
HLK66_06635	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HLK66_06640	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HLK66_06645	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HLK66_06665	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HLK66_06685	COG2267	carboxylic ester hydrolase activity
HLK66_06695	COG1744	ABC transporter substrate-binding protein PnrA-like
HLK66_06705	COG3711	transcriptional antiterminator
HLK66_06715	COG3730	PTS system glucitol sorbitol-specific
HLK66_06720	COG3732	PTS system glucitol sorbitol-specific
HLK66_06735	COG0561	phosphatase activity
HLK66_06745	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HLK66_06750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HLK66_06755	COG0735	belongs to the Fur family
HLK66_06760	COG5504	Zn-dependent protease
HLK66_06770	COG0180	Tryptophanyl-tRNA synthetase
HLK66_06775	COG4166	transmembrane transport
HLK66_06780	COG0601	transmembrane transport
HLK66_06785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLK66_06790	COG0444	Belongs to the ABC transporter superfamily
HLK66_06795	COG4608	Belongs to the ABC transporter superfamily
HLK66_06805	COG0456	acetyltransferase
HLK66_06810	COG1393	Belongs to the ArsC family
HLK66_06815	COG4862	establishment of competence for transformation
HLK66_06820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLK66_06830	COG1164	Oligoendopeptidase f
HLK66_06840	COG2346	COG2346, Truncated hemoglobins
HLK66_06845	COG0741	lytic transglycosylase activity
HLK66_06850	COG4116	CYTH
HLK66_06860	COG2357	RelA SpoT domain protein
HLK66_06870	COG0564	pseudouridine synthase activity
HLK66_06875	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HLK66_06880	COG2239	Acts as a magnesium transporter
HLK66_06885	COG0569	domain protein
HLK66_06885	COG0475	glutathione-regulated potassium exporter activity
HLK66_06890	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HLK66_06920	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HLK66_06940	COG0210	DNA helicase
HLK66_06950	COG2323	membrane
HLK66_06955	COG2153	protein acetylation
HLK66_06960	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HLK66_06965	COG2382	esterase
HLK66_06970	COG1328	CTP reductase activity
HLK66_06975	COG0602	queuosine metabolic process
HLK66_06985	COG0431	NADPH-dependent FMN reductase
HLK66_07005	COG0726	polysaccharide deacetylase
HLK66_07025	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HLK66_07035	COG1070	Carbohydrate kinase
HLK66_07045	COG2169	Transcriptional regulator
HLK66_07050	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HLK66_07055	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HLK66_07060	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HLK66_07065	COG1215	transferase activity, transferring glycosyl groups
HLK66_07070	COG1609	Transcriptional regulator
HLK66_07075	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HLK66_07080	COG0363	glucosamine-6-phosphate deaminase activity
HLK66_07085	COG2188	Transcriptional regulator
HLK66_07090	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HLK66_07095	COG1595	DNA-templated transcription, initiation
HLK66_07100	COG3104	oligopeptide transport
HLK66_07120	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HLK66_07130	COG2195	Cleaves the N-terminal amino acid of tripeptides
HLK66_07145	COG3347	Dehydrogenase
HLK66_07145	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_07160	COG1070	Carbohydrate kinase
HLK66_07165	COG4806	L-rhamnose isomerase
HLK66_07185	COG2972	Histidine kinase
HLK66_07205	COG4214	carbohydrate transport
HLK66_07210	COG1349	DNA-binding transcription factor activity
HLK66_07220	COG1366	Belongs to the anti-sigma-factor antagonist family
HLK66_07225	COG0366	Alpha amylase catalytic
HLK66_07230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_07230	COG1263	PTS System
HLK66_07230	COG2190	(PTS) system
HLK66_07235	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HLK66_07240	COG1442	glycosyl transferase family 8
HLK66_07245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLK66_07270	COG1216	Glycosyl transferase, family 2
HLK66_07275	COG3328	transposase activity
HLK66_07280	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HLK66_07285	COG3541	Predicted nucleotidyltransferase
HLK66_07295	COG1834	amidinotransferase
HLK66_07300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLK66_07305	COG1309	transcriptional regulator
HLK66_07310	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HLK66_07315	COG1523	belongs to the glycosyl hydrolase 13 family
HLK66_07330	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLK66_07335	COG1937	Protein conserved in bacteria
HLK66_07340	COG2210	Belongs to the sulfur carrier protein TusA family
HLK66_07345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLK66_07360	COG5577	PFAM Coat F domain
HLK66_07370	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HLK66_07375	COG3162	membrane
HLK66_07380	COG3546	catalase activity
HLK66_07385	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HLK66_07420	COG2205	protein histidine kinase activity
HLK66_07425	COG0745	RESPONSE REGULATOR receiver
HLK66_07475	COG1250	3-hydroxyacyl-CoA dehydrogenase
HLK66_07480	COG0840	transmembrane signaling receptor activity
HLK66_07485	COG0655	NAD(P)H dehydrogenase (quinone) activity
HLK66_07490	COG4753	response regulator
HLK66_07490	COG2207	Transcriptional regulator
HLK66_07495	COG2972	Histidine kinase
HLK66_07505	COG1175	transmembrane transport
HLK66_07540	COG2814	Major facilitator Superfamily
HLK66_07545	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLK66_07550	COG1116	anion transmembrane transporter activity
HLK66_07555	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLK66_07560	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLK66_07565	COG0697	spore germination
HLK66_07570	COG1609	Transcriptional regulator
HLK66_07575	COG4209	transmembrane transport
HLK66_07580	COG0395	ABC-type sugar transport system, permease component
HLK66_07590	COG1621	beta-fructofuranosidase activity
HLK66_07595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLK66_07600	COG1621	beta-fructofuranosidase activity
HLK66_07605	COG1621	beta-fructofuranosidase activity
HLK66_07610	COG1621	beta-fructofuranosidase activity
HLK66_07615	COG1653	transport
HLK66_07620	COG2207	Transcriptional regulator
HLK66_07620	COG4753	response regulator
HLK66_07625	COG2972	Histidine kinase
HLK66_07635	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HLK66_07640	COG2271	Major facilitator Superfamily
HLK66_07645	COG0405	Gamma-glutamyltransferase
HLK66_07660	COG2723	6-phospho-beta-galactosidase activity
HLK66_07665	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLK66_07670	COG2146	nitrite reductase [NAD(P)H] activity
HLK66_07675	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HLK66_07675	COG1587	Uroporphyrinogen-III synthase
HLK66_07685	COG2116	formate transmembrane transporter activity
HLK66_07690	COG3604	Transcriptional regulator
HLK66_07700	COG2223	nitrite transmembrane transporter activity
HLK66_07730	COG0523	cobalamin synthesis protein
HLK66_07735	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HLK66_07745	COG3588	fructose-bisphosphate aldolase
HLK66_07780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLK66_07790	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_07800	COG1175	transmembrane transport
HLK66_07805	COG0395	ABC-type sugar transport system, permease component
HLK66_07815	COG0673	inositol 2-dehydrogenase activity
HLK66_07825	COG0673	inositol 2-dehydrogenase activity
HLK66_07835	COG1082	Xylose isomerase domain protein TIM barrel
HLK66_07840	COG3773	Cell wall hydrolase
HLK66_07850	COG1136	(ABC) transporter
HLK66_07865	COG1732	Glycine betaine
HLK66_07875	COG2207	Transcriptional regulator
HLK66_07875	COG0662	Cupin 2, conserved barrel domain protein
HLK66_07890	COG0395	ABC-type sugar transport system, permease component
HLK66_07895	COG1874	Beta-galactosidase
HLK66_07900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HLK66_07905	COG3773	Cell wall hydrolase
HLK66_07915	COG1414	Transcriptional regulator
HLK66_07920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLK66_07925	COG0129	dihydroxy-acid dehydratase activity
HLK66_07935	COG3507	Belongs to the glycosyl hydrolase 43 family
HLK66_07950	COG0583	DNA-binding transcription factor activity
HLK66_07970	COG3842	ATPase activity
HLK66_07990	COG0584	glycerophosphoryl diester phosphodiesterase
HLK66_07995	COG0584	glycerophosphoryl diester phosphodiesterase
HLK66_08010	COG0142	geranyltranstransferase activity
HLK66_08015	COG1234	tRNA 3'-trailer cleavage
HLK66_08025	COG0154	amidase activity
HLK66_08045	COG2508	Transcriptional regulator
HLK66_08050	COG1953	Uracil, thiamine, allantoin
HLK66_08070	COG1266	CAAX protease self-immunity
HLK66_08080	COG0720	synthase
HLK66_08090	COG0302	gtp cyclohydrolase
HLK66_08100	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HLK66_08125	COG0431	NADPH-dependent FMN reductase
HLK66_08140	COG0395	ABC-type sugar transport system, permease component
HLK66_08145	COG3507	Belongs to the glycosyl hydrolase 43 family
HLK66_08150	COG5578	integral membrane protein
HLK66_08155	COG3940	Belongs to the glycosyl hydrolase 43 family
HLK66_08175	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HLK66_08180	COG2207	Transcriptional regulator
HLK66_08190	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLK66_08205	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HLK66_08210	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HLK66_08215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HLK66_08225	COG1113	amino acid transport
HLK66_08230	COG4555	ABC transporter
HLK66_08265	COG3850	Histidine kinase
HLK66_08265	COG5002	protein histidine kinase activity
HLK66_08270	COG1136	(ABC) transporter
HLK66_08280	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HLK66_08290	COG1012	belongs to the aldehyde dehydrogenase family
HLK66_08295	COG1595	DNA-templated transcription, initiation
HLK66_08325	COG0366	Alpha amylase catalytic
HLK66_08330	COG2017	converts alpha-aldose to the beta-anomer
HLK66_08335	COG1175	transmembrane transport
HLK66_08340	COG0395	ABC-type sugar transport system, permease component
HLK66_08350	COG3254	rhamnose metabolic process
HLK66_08355	COG5578	integral membrane protein
HLK66_08370	COG2972	Histidine kinase
HLK66_08375	COG2207	Transcriptional regulator
HLK66_08375	COG4753	response regulator
HLK66_08405	COG1266	CAAX protease self-immunity
HLK66_08410	COG1404	Belongs to the peptidase S8 family
HLK66_08415	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HLK66_08430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HLK66_08435	COG2169	Transcriptional regulator
HLK66_08445	COG0673	inositol 2-dehydrogenase activity
HLK66_08450	COG1082	Xylose isomerase domain protein TIM barrel
HLK66_08455	COG0673	inositol 2-dehydrogenase activity
HLK66_08460	COG0803	Belongs to the bacterial solute-binding protein 9 family
HLK66_08475	COG1595	DNA-templated transcription, initiation
HLK66_08485	COG0772	Belongs to the SEDS family
HLK66_08495	COG0583	DNA-binding transcription factor activity
HLK66_08500	COG1063	alcohol dehydrogenase
HLK66_08505	COG2814	Major facilitator Superfamily
HLK66_08515	COG1113	amino acid transport
HLK66_08520	COG2205	protein histidine kinase activity
HLK66_08530	COG1252	NADH dehydrogenase
HLK66_08540	COG0778	Nitroreductase
HLK66_08545	COG0252	asparaginase activity
HLK66_08550	COG4193	domain, Protein
HLK66_08555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLK66_08560	COG0791	NLP P60 protein
HLK66_08560	COG3883	PFAM NLP P60 protein
HLK66_08565	COG1121	(ABC) transporter
HLK66_08570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLK66_08590	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HLK66_08605	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HLK66_08610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_08615	COG1119	ATPase activity
HLK66_08620	COG0561	phosphatase activity
HLK66_08630	COG1585	Membrane protein implicated in regulation of membrane protease activity
HLK66_08635	COG2268	Band 7 protein
HLK66_08640	COG2113	Glycine betaine
HLK66_08645	COG4176	ABC-type proline glycine betaine transport system permease component
HLK66_08650	COG4175	Glycine betaine
HLK66_08650	COG0517	IMP dehydrogenase activity
HLK66_08655	COG1510	regulation of RNA biosynthetic process
HLK66_08670	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HLK66_08675	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HLK66_08680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLK66_08685	COG4597	amino acid ABC transporter
HLK66_08695	COG1126	abc transporter atp-binding protein
HLK66_08705	COG0861	Integral membrane protein TerC family
HLK66_08715	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLK66_08730	COG3594	Acyltransferase
HLK66_08735	COG5002	protein histidine kinase activity
HLK66_08745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HLK66_08760	COG3852	Histidine kinase
HLK66_08765	COG1846	Transcriptional regulator
HLK66_08775	COG0542	response to heat
HLK66_08780	COG3949	Membrane
HLK66_08795	COG4873	Protein conserved in bacteria
HLK66_08815	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HLK66_08820	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HLK66_08825	COG2084	Dehydrogenase
HLK66_08830	COG0436	Aminotransferase
HLK66_08850	COG0784	Response regulator, receiver
HLK66_08850	COG0835	chemotaxis
HLK66_08865	COG5001	Diguanylate cyclase
HLK66_08865	COG3300	MHYT domain
HLK66_08870	COG4990	cell redox homeostasis
HLK66_08875	COG2200	EAL domain
HLK66_08890	COG4703	Protein of unknown function (DUF1797)
HLK66_08895	COG0517	IMP dehydrogenase activity
HLK66_08900	COG0583	DNA-binding transcription factor activity
HLK66_08905	COG2171	N-acyltransferase activity
HLK66_08915	COG0668	transmembrane transport
HLK66_08930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLK66_08935	COG0569	domain protein
HLK66_08945	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HLK66_08970	COG0022	dehydrogenase e1 component
HLK66_08975	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLK66_08995	COG1982	Orn Lys Arg decarboxylase major
HLK66_09005	COG4493	Belongs to the UPF0637 family
HLK66_09015	COG0483	inositol monophosphate 1-phosphatase activity
HLK66_09030	COG4896	Protein conserved in bacteria
HLK66_09040	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HLK66_09045	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HLK66_09055	COG0772	Belongs to the SEDS family
HLK66_09070	COG2340	Cysteine-rich secretory protein family
HLK66_09090	COG3679	Belongs to the UPF0342 family
HLK66_09095	COG4471	UPF0298 protein
HLK66_09100	COG0742	ribosomal rna small subunit methyltransferase
HLK66_09105	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HLK66_09110	COG3314	Sporulation integral membrane protein YlbJ
HLK66_09115	COG1752	Esterase of the alpha-beta hydrolase superfamily
HLK66_09120	COG1323	Belongs to the UPF0348 family
HLK66_09125	COG1399	metal-binding, possibly nucleic acid-binding protein
HLK66_09130	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HLK66_09135	COG1683	Conserved Protein
HLK66_09155	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HLK66_09160	COG3344	reverse transcriptase
HLK66_09165	COG2001	Belongs to the MraZ family
HLK66_09190	COG0768	penicillin binding
HLK66_09195	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HLK66_09205	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HLK66_09210	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HLK66_09215	COG0772	Belongs to the SEDS family
HLK66_09220	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HLK66_09225	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HLK66_09230	COG3879	Bacterial protein of unknown function (DUF881)
HLK66_09235	COG3879	Bacterial protein of unknown function (DUF881)
HLK66_09240	COG3856	small basic protein
HLK66_09245	COG0849	cell division
HLK66_09250	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HLK66_09255	COG3344	reverse transcriptase
HLK66_09265	COG1191	sigma factor activity
HLK66_09270	COG1191	sigma factor activity
HLK66_09280	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HLK66_09285	COG1799	cell septum assembly
HLK66_09290	COG0762	integral membrane protein
HLK66_09295	COG2302	S4 RNA-binding domain
HLK66_09300	COG3599	regulation of cell shape
HLK66_09305	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HLK66_09310	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HLK66_09315	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HLK66_09320	COG0564	pseudouridine synthase activity
HLK66_09325	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HLK66_09335	COG0540	Belongs to the ATCase OTCase family
HLK66_09350	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HLK66_09360	COG0167	dihydroorotate dehydrogenase activity
HLK66_09380	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HLK66_09385	COG1561	YicC-like family, N-terminal region
HLK66_09395	COG0194	GDP metabolic process
HLK66_09405	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HLK66_09410	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HLK66_09430	COG3833	ABC-type maltose transport systems, permease component
HLK66_09440	COG3250	beta-galactosidase activity
HLK66_09445	COG3250	beta-galactosidase activity
HLK66_09455	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HLK66_09460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HLK66_09460	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HLK66_09470	COG0631	protein serine/threonine phosphatase activity
HLK66_09475	COG2815	serine threonine protein kinase
HLK66_09475	COG0515	serine threonine protein kinase
HLK66_09480	COG1162	GTPase activity
HLK66_09485	COG1564	THIamine pyrophosphokinase
HLK66_09495	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HLK66_09500	COG1302	Protein conserved in bacteria
HLK66_09505	COG1461	Dihydroxyacetone kinase
HLK66_09510	COG1760	l-serine dehydratase
HLK66_09515	COG1760	l-serine dehydratase
HLK66_09525	COG1349	DNA-binding transcription factor activity
HLK66_09530	COG0416	fatty acid biosynthetic process
HLK66_09535	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HLK66_09540	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_09545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HLK66_09550	COG0571	ribonuclease III activity
HLK66_09555	COG1196	nuclear chromosome segregation
HLK66_09560	COG0552	protein localization to endoplasmic reticulum
HLK66_09575	COG1131	(ABC) transporter
HLK66_09590	COG0714	Associated with various cellular activities
HLK66_09610	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HLK66_09615	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HLK66_09625	COG1837	Belongs to the UPF0109 family
HLK66_09635	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HLK66_09650	COG0681	Belongs to the peptidase S26 family
HLK66_09655	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HLK66_09670	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HLK66_09675	COG0045	succinate-CoA ligase (ADP-forming) activity
HLK66_09680	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HLK66_09685	COG0758	DNA mediated transformation
HLK66_09690	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HLK66_09695	COG4974	Belongs to the 'phage' integrase family
HLK66_09705	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HLK66_09710	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HLK66_09715	COG1815	bacterial-type flagellum-dependent cell motility
HLK66_09720	COG1558	bacterial-type flagellum-dependent cell motility
HLK66_09725	COG1677	Flagellar hook-basal body complex protein FliE
HLK66_09730	COG1766	The M ring may be actively involved in energy transduction
HLK66_09735	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HLK66_09740	COG1317	bacterial-type flagellum organization
HLK66_09745	COG1157	protein secretion by the type III secretion system
HLK66_09750	COG2882	bacterial-type flagellum organization
HLK66_09765	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HLK66_09775	COG4786	Flagellar basal body rod
HLK66_09780	COG1582	Flagellar protein (FlbD)
HLK66_09785	COG1580	Controls the rotational direction of flagella during chemotaxis
HLK66_09790	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HLK66_09795	COG1776	CheC inhibitor of MCP methylation
HLK66_09795	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HLK66_09800	COG2201	protein-glutamate methylesterase activity
HLK66_09805	COG3190	flagellar
HLK66_09810	COG1338	Plays a role in the flagellum-specific transport system
HLK66_09815	COG1987	bacterial-type flagellum assembly
HLK66_09820	COG1684	flagellar biosynthetic protein fliR
HLK66_09825	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HLK66_09830	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HLK66_09835	COG1419	protein localization to endoplasmic reticulum
HLK66_09840	COG0455	bacterial-type flagellum organization
HLK66_09845	COG2201	protein-glutamate methylesterase activity
HLK66_09850	COG2198	Histidine kinase
HLK66_09850	COG0643	Histidine kinase
HLK66_09855	COG0835	chemotaxis
HLK66_09860	COG1776	CheC inhibitor of MCP methylation
HLK66_09865	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HLK66_09870	COG1191	sigma factor activity
HLK66_09900	COG0233	cytoplasmic translational termination
HLK66_09910	COG4589	Belongs to the CDS family
HLK66_09920	COG0750	zinc metalloprotease
HLK66_09925	COG0442	prolyl-tRNA aminoacylation
HLK66_09930	COG2176	DNA-directed DNA polymerase activity
HLK66_09935	COG0779	Required for maturation of 30S ribosomal subunits
HLK66_09940	COG0195	Participates in both transcription termination and antitermination
HLK66_09945	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HLK66_09950	COG1358	cellular component organization or biogenesis
HLK66_09960	COG1550	Protein conserved in bacteria
HLK66_09970	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HLK66_09975	COG0196	riboflavin kinase activity
HLK66_09980	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HLK66_09985	COG1185	polyribonucleotide nucleotidyltransferase activity
HLK66_09990	COG0726	polysaccharide deacetylase
HLK66_09995	COG0612	Peptidase, M16
HLK66_10000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HLK66_10005	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HLK66_10010	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HLK66_10015	COG0527	aspartate kinase activity
HLK66_10020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLK66_10025	COG1113	amino acid transport
HLK66_10030	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HLK66_10035	COG0740	serine-type endopeptidase activity
HLK66_10050	COG4980	gas vesicle protein
HLK66_10050	COG1674	ftsk spoiiie
HLK66_10055	COG2188	Transcriptional regulator
HLK66_10090	COG0612	Peptidase, M16
HLK66_10095	COG0612	Peptidase, M16
HLK66_10100	COG0300	oxidoreductase activity
HLK66_10115	COG1426	Protein conserved in bacteria
HLK66_10120	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HLK66_10125	COG1546	Belongs to the CinA family
HLK66_10125	COG1058	Belongs to the CinA family
HLK66_10130	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HLK66_10135	COG1418	mRNA catabolic process
HLK66_10140	COG3344	reverse transcriptase
HLK66_10145	COG1692	metallophosphoesterase
HLK66_10150	COG2359	stage V sporulation protein S
HLK66_10160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HLK66_10165	COG4550	Control of competence regulator ComK, YlbF/YmcA
HLK66_10170	COG3344	reverse transcriptase
HLK66_10200	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HLK66_10205	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HLK66_10220	COG3711	transcriptional antiterminator
HLK66_10220	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_10235	COG3711	transcriptional antiterminator
HLK66_10235	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_10240	COG1447	Phosphotransferase system cellobiose-specific component IIA
HLK66_10275	COG2217	Heavy metal translocating P-type atpase
HLK66_10285	COG0586	Pfam SNARE associated Golgi protein
HLK66_10300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLK66_10315	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HLK66_10320	COG2271	Major facilitator Superfamily
HLK66_10325	COG1846	Transcriptional regulator
HLK66_10325	COG0456	acetyltransferase
HLK66_10330	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HLK66_10335	COG0583	DNA-binding transcription factor activity
HLK66_10350	COG2318	DinB family
HLK66_10355	COG2207	Transcriptional regulator
HLK66_10365	COG1309	transcriptional regulator
HLK66_10370	COG3773	Cell wall hydrolase
HLK66_10405	COG0531	amino acid
HLK66_10420	COG0640	Transcriptional regulator
HLK66_10440	COG3848	Pyruvate phosphate dikinase
HLK66_10440	COG0574	Belongs to the PEP-utilizing enzyme family
HLK66_10445	COG1794	racemase activity, acting on amino acids and derivatives
HLK66_10450	COG0076	glutamate decarboxylase activity
HLK66_10455	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_10470	COG0768	penicillin binding
HLK66_10500	COG0723	plastoquinol--plastocyanin reductase activity
HLK66_10500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLK66_10530	COG3715	PTS system
HLK66_10535	COG3716	PTS system mannose fructose sorbose family IID component
HLK66_10540	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_10540	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_10545	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HLK66_10575	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_10585	COG2207	Transcriptional regulator
HLK66_10585	COG3708	Transcriptional regulator
HLK66_10590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLK66_10620	COG3546	catalase activity
HLK66_10645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLK66_10680	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HLK66_10685	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HLK66_10690	COG0217	transcriptional regulatory protein
HLK66_10700	COG0789	Transcriptional regulator
HLK66_10740	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HLK66_10750	COG0454	-acetyltransferase
HLK66_10755	COG2814	Major facilitator Superfamily
HLK66_10765	COG2318	DinB family
HLK66_10790	COG0456	acetyltransferase
HLK66_10815	COG0596	Alpha beta hydrolase
HLK66_10830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLK66_10860	COG0640	Transcriptional regulator
HLK66_10875	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_10885	COG1309	transcriptional regulator
HLK66_10890	COG2814	Major facilitator Superfamily
HLK66_10910	COG5002	protein histidine kinase activity
HLK66_10970	COG2267	carboxylic ester hydrolase activity
HLK66_10995	COG3708	Transcriptional regulator
HLK66_10995	COG2207	Transcriptional regulator
HLK66_11010	COG0018	arginyl-trna synthetase
HLK66_11015	COG4549	nuclear export factor GLE1
HLK66_11025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLK66_11035	COG0592	DNA-directed DNA polymerase activity
HLK66_11040	COG2329	Antibiotic biosynthesis monooxygenase
HLK66_11100	COG2226	methyltransferase
HLK66_11120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLK66_11140	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HLK66_11145	COG0022	dehydrogenase e1 component
HLK66_11150	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLK66_11155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLK66_11160	COG0316	Belongs to the HesB IscA family
HLK66_11190	COG3655	Transcriptional regulator
HLK66_11195	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HLK66_11210	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HLK66_11215	COG3002	Belongs to the UPF0753 family
HLK66_11220	COG0288	reversible hydration of carbon dioxide
HLK66_11225	COG5609	conserved protein (DUF2294)
HLK66_11275	COG2076	Multidrug Resistance protein
HLK66_11280	COG2076	Multidrug Resistance protein
HLK66_11285	COG1309	transcriptional regulator
HLK66_11300	COG0412	Dienelactone hydrolase
HLK66_11330	COG0583	DNA-binding transcription factor activity
HLK66_11335	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_11380	COG5002	protein histidine kinase activity
HLK66_11385	COG0494	nUDIX hydrolase
HLK66_11435	COG2267	carboxylic ester hydrolase activity
HLK66_11445	COG2244	polysaccharide biosynthetic process
HLK66_11490	COG1104	cysteine desulfurase activity
HLK66_11495	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HLK66_11500	COG0157	Belongs to the NadC ModD family
HLK66_11505	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HLK66_11515	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HLK66_11525	COG0464	growth
HLK66_11530	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HLK66_11535	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HLK66_11540	COG0789	Transcriptional regulator
HLK66_11545	COG0174	glutamine synthetase
HLK66_11565	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HLK66_11600	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HLK66_11645	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HLK66_11655	COG2080	2 iron, 2 sulfur cluster binding
HLK66_11670	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HLK66_11675	COG3344	reverse transcriptase
HLK66_11685	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HLK66_11695	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HLK66_11700	COG4224	UPF0291 protein
HLK66_11705	COG3344	reverse transcriptase
HLK66_11720	COG3763	UPF0154 protein
HLK66_11740	COG1132	(ABC) transporter
HLK66_11745	COG1132	(ABC) transporter
HLK66_11755	COG0785	Cytochrome C biogenesis protein
HLK66_11760	COG2201	protein-glutamate methylesterase activity
HLK66_11765	COG4846	Membrane protein involved in cytochrome C biogenesis
HLK66_11800	COG0420	3'-5' exonuclease activity
HLK66_11810	COG1876	peptidase activity
HLK66_11815	COG1363	Peptidase, m42
HLK66_11820	COG1368	sulfuric ester hydrolase activity
HLK66_11825	COG3973	AAA domain
HLK66_11830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLK66_11840	COG3764	Sortase (surface protein transpeptidase)
HLK66_11855	COG0456	acetyltransferase
HLK66_11860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLK66_11870	COG3344	reverse transcriptase
HLK66_11880	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HLK66_11890	COG5577	PFAM Coat F domain
HLK66_11895	COG1063	alcohol dehydrogenase
HLK66_11905	COG5577	PFAM Coat F domain
HLK66_11910	COG1486	melibiose metabolic process
HLK66_11925	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HLK66_11930	COG1247	-acetyltransferase
HLK66_11945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLK66_11955	COG1227	inorganic diphosphatase activity
HLK66_11960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLK66_11975	COG0464	growth
HLK66_11995	COG4841	protein insertion into membrane
HLK66_12000	COG2843	Capsule synthesis protein
HLK66_12005	COG3852	Histidine kinase
HLK66_12010	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HLK66_12035	COG3153	acetyltransferase
HLK66_12035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HLK66_12045	COG5504	Zn-dependent protease
HLK66_12050	COG1846	Transcriptional regulator
HLK66_12055	COG0477	Major facilitator Superfamily
HLK66_12060	COG3344	reverse transcriptase
HLK66_12065	COG2755	lipolytic protein G-D-S-L family
HLK66_12085	COG1410	methionine synthase
HLK66_12085	COG0646	methionine synthase
HLK66_12090	COG0646	methionine synthase
HLK66_12090	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HLK66_12095	COG0626	cystathionine gamma-synthase activity
HLK66_12100	COG0626	cystathionine gamma-synthase activity
HLK66_12110	COG0745	RESPONSE REGULATOR receiver
HLK66_12115	COG5002	protein histidine kinase activity
HLK66_12120	COG0567	Dehydrogenase, E1 component
HLK66_12125	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLK66_12145	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HLK66_12165	COG1335	isochorismatase
HLK66_12185	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HLK66_12195	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HLK66_12195	COG0392	lysyltransferase activity
HLK66_12200	COG1686	Belongs to the peptidase S11 family
HLK66_12205	COG3344	reverse transcriptase
HLK66_12210	COG0488	(ABC) transporter
HLK66_12215	COG2116	formate transmembrane transporter activity
HLK66_12240	COG0514	ATP-dependent DNA helicase (RecQ)
HLK66_12245	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HLK66_12260	COG3584	3D domain protein
HLK66_12260	COG1388	LysM domain
HLK66_12275	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HLK66_12285	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HLK66_12290	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HLK66_12295	COG2080	2 iron, 2 sulfur cluster binding
HLK66_12300	COG3195	allantoin biosynthetic process
HLK66_12300	COG3648	Uricase
HLK66_12305	COG2351	hydroxyisourate hydrolase activity
HLK66_12310	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HLK66_12320	COG2223	nitrite transmembrane transporter activity
HLK66_12335	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HLK66_12345	COG0561	phosphatase activity
HLK66_12355	COG1164	Oligoendopeptidase f
HLK66_12360	COG0583	DNA-binding transcription factor activity
HLK66_12365	COG0070	glutamate synthase
HLK66_12365	COG0069	glutamate synthase activity
HLK66_12365	COG0067	glutamate synthase
HLK66_12370	COG0493	'glutamate synthase
HLK66_12375	COG1418	mRNA catabolic process
HLK66_12385	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HLK66_12390	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HLK66_12395	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_12400	COG0861	Integral membrane protein TerC family
HLK66_12405	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HLK66_12420	COG0681	Belongs to the peptidase S26 family
HLK66_12430	COG1725	Transcriptional regulator
HLK66_12445	COG4974	Belongs to the 'phage' integrase family
HLK66_12460	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HLK66_12465	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HLK66_12465	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HLK66_12470	COG0307	riboflavin synthase, alpha
HLK66_12475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLK66_12480	COG0708	Exodeoxyribonuclease III
HLK66_12485	COG0346	lactoylglutathione lyase activity
HLK66_12490	COG0561	phosphatase activity
HLK66_12510	COG1366	Belongs to the anti-sigma-factor antagonist family
HLK66_12530	COG1733	regulation of RNA biosynthetic process
HLK66_12535	COG2249	NAD(P)H dehydrogenase (quinone) activity
HLK66_12545	COG2027	D-alanyl-D-alanine carboxypeptidase
HLK66_12555	COG3341	Caulimovirus viroplasmin
HLK66_12555	COG0328	RNA-DNA hybrid ribonuclease activity
HLK66_12560	COG3275	phosphorelay sensor kinase activity
HLK66_12570	COG1966	Carbon starvation protein
HLK66_12580	COG3300	MHYT domain
HLK66_12580	COG5001	Diguanylate cyclase
HLK66_12585	COG2066	Belongs to the glutaminase family
HLK66_12590	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HLK66_12600	COG0840	transmembrane signaling receptor activity
HLK66_12610	COG1280	lysine exporter protein (LysE YggA)
HLK66_12615	COG0024	Methionine aminopeptidase
HLK66_12625	COG0531	amino acid
HLK66_12650	COG0045	succinate-CoA ligase (ADP-forming) activity
HLK66_12650	COG1042	CoA-binding domain protein
HLK66_12650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLK66_12655	COG0753	catalase activity
HLK66_12660	COG0326	Molecular chaperone. Has ATPase activity
HLK66_12665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLK66_12670	COG1280	lysine exporter protein (LysE YggA)
HLK66_12715	COG3689	TIGRFAM TIGR03943 family protein
HLK66_12720	COG0701	Predicted permease
HLK66_12735	COG0492	ferredoxin-NADP+ reductase activity
HLK66_12740	COG1609	Transcriptional regulator
HLK66_12745	COG1621	beta-fructofuranosidase activity
HLK66_12760	COG0583	DNA-binding transcription factor activity
HLK66_12775	COG1349	DNA-binding transcription factor activity
HLK66_12780	COG4977	sequence-specific DNA binding
HLK66_12795	COG1051	belongs to the nudix hydrolase family
HLK66_12800	COG4473	ABC transporter
HLK66_12805	COG1131	(ABC) transporter
HLK66_12810	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HLK66_12830	COG0406	alpha-ribazole phosphatase activity
HLK66_12860	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HLK66_12870	COG1832	CoA-binding protein
HLK66_12890	COG3858	chitin binding
HLK66_12905	COG3859	Proton-coupled thiamine transporter YuaJ
HLK66_12915	COG1309	transcriptional regulator
HLK66_12930	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLK66_12935	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HLK66_12940	COG0204	Acyl-transferase
HLK66_12945	COG0561	phosphatase activity
HLK66_12950	COG1349	DNA-binding transcription factor activity
HLK66_12965	COG1482	cell wall glycoprotein biosynthetic process
HLK66_12970	COG1404	Belongs to the peptidase S8 family
HLK66_12975	COG2814	Major facilitator Superfamily
HLK66_13000	COG1268	BioY protein
HLK66_13005	COG1276	copper resistance
HLK66_13005	COG2372	response to copper ion
HLK66_13025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLK66_13030	COG0737	Belongs to the 5'-nucleotidase family
HLK66_13040	COG0561	phosphatase activity
HLK66_13050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLK66_13055	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HLK66_13070	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLK66_13080	COG1011	Hydrolase
HLK66_13085	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HLK66_13115	COG1695	Transcriptional regulator
HLK66_13125	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HLK66_13130	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HLK66_13135	COG0561	phosphatase activity
HLK66_13140	COG0697	spore germination
HLK66_13145	COG1132	(ABC) transporter
HLK66_13150	COG0583	DNA-binding transcription factor activity
HLK66_13175	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HLK66_13180	COG0512	Glutamine amidotransferase of anthranilate synthase
HLK66_13180	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HLK66_13185	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HLK66_13190	COG2258	MOSC domain
HLK66_13195	COG2814	Major facilitator Superfamily
HLK66_13200	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLK66_13200	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLK66_13200	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_13205	COG1105	Belongs to the carbohydrate kinase PfkB family
HLK66_13210	COG1349	DNA-binding transcription factor activity
HLK66_13225	COG2176	DNA-directed DNA polymerase activity
HLK66_13235	COG0004	ammonium transporteR
HLK66_13250	COG0351	phosphomethylpyrimidine kinase
HLK66_13265	COG0701	Predicted permease
HLK66_13270	COG0523	cobalamin synthesis protein
HLK66_13275	COG0840	transmembrane signaling receptor activity
HLK66_13285	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HLK66_13305	COG2267	carboxylic ester hydrolase activity
HLK66_13310	COG0596	Alpha beta hydrolase
HLK66_13325	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HLK66_13330	COG1737	Transcriptional regulator
HLK66_13335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_13335	COG1263	PTS System
HLK66_13350	COG1609	Transcriptional regulator
HLK66_13360	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HLK66_13365	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HLK66_13370	COG0523	cobalamin synthesis protein
HLK66_13415	COG2849	repeat protein
HLK66_13480	COG3739	integral membrane protein
HLK66_13485	COG3655	Transcriptional regulator
HLK66_13500	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HLK66_13505	COG5646	InterPro IPR014922
HLK66_13535	COG1595	DNA-templated transcription, initiation
HLK66_13550	COG1357	PFAM Pentapeptide repeats (8 copies)
HLK66_13575	COG2155	Conserved Protein
HLK66_13580	COG2733	membrane
HLK66_13600	COG0384	phenazine biosynthesis protein PhzF
HLK66_13625	COG2207	Transcriptional regulator
HLK66_13625	COG3708	Transcriptional regulator
HLK66_13630	COG1115	amino acid carrier protein
HLK66_13660	COG1690	Belongs to the RtcB family
HLK66_13665	COG4377	Putative membrane peptidase family (DUF2324)
HLK66_13680	COG0586	Pfam SNARE associated Golgi protein
HLK66_13700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLK66_13710	COG0406	alpha-ribazole phosphatase activity
HLK66_13715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLK66_13765	COG0726	polysaccharide deacetylase
HLK66_13790	COG0583	DNA-binding transcription factor activity
HLK66_13800	COG1346	cytolysis
HLK66_13825	COG0513	Belongs to the DEAD box helicase family
HLK66_13835	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HLK66_13840	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HLK66_13850	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HLK66_13855	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HLK66_13860	COG0671	phosphoesterase, PA-phosphatase related
HLK66_13865	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HLK66_13870	COG1793	dna ligase
HLK66_13870	COG3285	dna ligase
HLK66_13880	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HLK66_13885	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HLK66_13915	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HLK66_13920	COG0640	Transcriptional regulator
HLK66_13925	COG0534	Mate efflux family protein
HLK66_13945	COG2340	Cysteine-rich secretory protein family
HLK66_13960	COG0523	cobalamin synthesis protein
HLK66_13965	COG0793	Belongs to the peptidase S41A family
HLK66_13965	COG3409	Peptidoglycan-binding domain 1 protein
HLK66_13970	COG1876	peptidase activity
HLK66_14000	COG4479	Belongs to the UPF0346 family
HLK66_14010	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HLK66_14035	COG2755	lipolytic protein G-D-S-L family
HLK66_14040	COG5002	protein histidine kinase activity
HLK66_14045	COG1307	EDD domain protein, DegV family
HLK66_14050	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HLK66_14055	COG1272	protein, Hemolysin III
HLK66_14060	COG3716	PTS system mannose fructose sorbose family IID component
HLK66_14065	COG3715	PTS system
HLK66_14070	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_14085	COG2188	Transcriptional regulator
HLK66_14090	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HLK66_14105	COG2310	stress, protein
HLK66_14110	COG2310	stress, protein
HLK66_14115	COG3853	Toxic anion resistance protein (TelA)
HLK66_14135	COG1358	cellular component organization or biogenesis
HLK66_14150	COG0861	Integral membrane protein TerC family
HLK66_14155	COG2310	stress, protein
HLK66_14165	COG2521	methyltransferase
HLK66_14165	COG2136	Putative SAM-dependent methyltransferase
HLK66_14175	COG1413	lyase activity
HLK66_14185	COG1418	mRNA catabolic process
HLK66_14205	COG0386	Belongs to the glutathione peroxidase family
HLK66_14220	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HLK66_14235	COG1321	iron dependent repressor
HLK66_14240	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HLK66_14240	COG0551	DNA topoisomerase type I activity
HLK66_14245	COG4129	membrane
HLK66_14260	COG1278	Cold shock
HLK66_14270	COG0328	RNA-DNA hybrid ribonuclease activity
HLK66_14275	COG0328	RNA-DNA hybrid ribonuclease activity
HLK66_14285	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HLK66_14295	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HLK66_14305	COG1131	(ABC) transporter
HLK66_14320	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HLK66_14330	COG3344	reverse transcriptase
HLK66_14335	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HLK66_14340	COG1199	ATP-dependent helicase activity
HLK66_14350	COG0116	Belongs to the methyltransferase superfamily
HLK66_14365	COG4474	Belongs to the UPF0398 family
HLK66_14375	COG3359	exonuclease
HLK66_14385	COG2267	carboxylic ester hydrolase activity
HLK66_14390	COG0071	Belongs to the small heat shock protein (HSP20) family
HLK66_14425	COG3331	DNA recombination
HLK66_14430	COG4499	WXG100 protein secretion system (Wss), protein YukC
HLK66_14430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLK66_14440	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HLK66_14445	COG3935	DnaD domain protein
HLK66_14450	COG0017	Asparaginyl-tRNA synthetase
HLK66_14455	COG0436	Aminotransferase
HLK66_14465	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HLK66_14465	COG1199	ATP-dependent helicase activity
HLK66_14470	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HLK66_14475	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HLK66_14480	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HLK66_14490	COG0617	tRNA 3'-terminal CCA addition
HLK66_14495	COG0438	transferase activity, transferring glycosyl groups
HLK66_14500	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HLK66_14510	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HLK66_14515	COG1694	Mazg nucleotide pyrophosphohydrolase
HLK66_14520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLK66_14530	COG2223	nitrite transmembrane transporter activity
HLK66_14535	COG2738	Putative neutral zinc metallopeptidase
HLK66_14545	COG4347	Protein of unknown function (DUF1405)
HLK66_14550	COG5582	Belongs to the UPF0302 family
HLK66_14555	COG0457	Tetratricopeptide repeat
HLK66_14565	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HLK66_14570	COG0287	Prephenate dehydrogenase
HLK66_14575	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HLK66_14580	COG4401	Chorismate mutase type I
HLK66_14585	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HLK66_14595	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HLK66_14600	COG0105	UTP biosynthetic process
HLK66_14605	COG0142	geranyltranstransferase activity
HLK66_14610	COG2226	methyltransferase
HLK66_14615	COG0142	geranyltranstransferase activity
HLK66_14620	COG0776	regulation of translation
HLK66_14625	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HLK66_14630	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HLK66_14635	COG1160	GTP binding
HLK66_14655	COG0539	negative regulation of cytoplasmic translation
HLK66_14675	COG2959	enzyme of heme biosynthesis
HLK66_14680	COG3773	Cell wall hydrolase
HLK66_14680	COG3409	Peptidoglycan-binding domain 1 protein
HLK66_14685	COG2339	peptidase activity
HLK66_14690	COG0492	ferredoxin-NADP+ reductase activity
HLK66_14695	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HLK66_14700	COG4862	establishment of competence for transformation
HLK66_14705	COG1408	metallophosphoesterase
HLK66_14720	COG3546	catalase activity
HLK66_14735	COG1266	CAAX protease self-immunity
HLK66_14740	COG0514	ATP-dependent DNA helicase (RecQ)
HLK66_14750	COG1141	Ferredoxin
HLK66_14755	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HLK66_14760	COG0739	heme binding
HLK66_14775	COG1595	DNA-templated transcription, initiation
HLK66_14780	COG5002	protein histidine kinase activity
HLK66_14785	COG0745	RESPONSE REGULATOR receiver
HLK66_14790	COG1187	pseudouridine synthase activity
HLK66_14795	COG0700	Nucleoside recognition
HLK66_14800	COG2715	membrane protein required for spore maturation
HLK66_14805	COG1686	Belongs to the peptidase S11 family
HLK66_14810	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HLK66_14815	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HLK66_14820	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HLK66_14825	COG1547	Domain of unknown function (DUF309)
HLK66_14835	COG4086	secreted protein
HLK66_14850	COG0697	spore germination
HLK66_14875	COG2172	sigma factor antagonist activity
HLK66_14885	COG1686	Belongs to the peptidase S11 family
HLK66_14890	COG0024	Methionine aminopeptidase
HLK66_14895	COG1595	DNA-templated transcription, initiation
HLK66_14915	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HLK66_14950	COG4974	Belongs to the 'phage' integrase family
HLK66_14960	COG0735	belongs to the Fur family
HLK66_14965	COG1300	Membrane
HLK66_14975	COG1379	DNA repair
HLK66_14990	COG0667	Aldo Keto reductase
HLK66_15010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLK66_15015	COG0456	acetyltransferase
HLK66_15020	COG0346	lactoylglutathione lyase activity
HLK66_15025	COG1078	dGTPase activity
HLK66_15055	COG2271	Major facilitator Superfamily
HLK66_15060	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_15065	COG1063	alcohol dehydrogenase
HLK66_15070	COG4948	Mandelate Racemase Muconate Lactonizing
HLK66_15115	COG1595	DNA-templated transcription, initiation
HLK66_15140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLK66_15145	COG3620	sequence-specific DNA binding
HLK66_15175	COG1764	response to oxidative stress
HLK66_15180	COG1073	alpha beta
HLK66_15185	COG2814	Major facilitator Superfamily
HLK66_15190	COG0640	Transcriptional regulator
HLK66_15235	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HLK66_15240	COG2814	Major facilitator Superfamily
HLK66_15245	COG1846	Transcriptional regulator
HLK66_15255	COG0300	oxidoreductase activity
HLK66_15265	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HLK66_15270	COG1234	tRNA 3'-trailer cleavage
HLK66_15275	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HLK66_15280	COG1408	metallophosphoesterase
HLK66_15290	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HLK66_15295	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HLK66_15305	COG2195	Cleaves the N-terminal amino acid of tripeptides
HLK66_15315	COG1376	ErfK ybiS ycfS ynhG family protein
HLK66_15320	COG1126	abc transporter atp-binding protein
HLK66_15325	COG0765	amino acid transport
HLK66_15330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLK66_15340	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLK66_15345	COG0022	dehydrogenase e1 component
HLK66_15350	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HLK66_15355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLK66_15360	COG3426	butyrate kinase activity
HLK66_15365	COG3290	protein histidine kinase activity
HLK66_15365	COG3829	transcription factor binding
HLK66_15370	COG0584	glycerophosphoryl diester phosphodiesterase
HLK66_15385	COG0745	RESPONSE REGULATOR receiver
HLK66_15390	COG1575	Belongs to the MenA family. Type 1 subfamily
HLK66_15395	COG0750	zinc metalloprotease
HLK66_15400	COG0497	DNA recombination
HLK66_15405	COG1438	arginine binding
HLK66_15410	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HLK66_15415	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HLK66_15420	COG0142	geranyltranstransferase activity
HLK66_15425	COG1722	exodeoxyribonuclease VII activity
HLK66_15440	COG1302	Protein conserved in bacteria
HLK66_15445	COG0439	Biotin carboxylase
HLK66_15450	COG0511	ligase activity, forming carbon-carbon bonds
HLK66_15490	COG3854	ATPases associated with a variety of cellular activities
HLK66_15500	COG1785	Belongs to the alkaline phosphatase family
HLK66_15510	COG2723	6-phospho-beta-galactosidase activity
HLK66_15515	COG1501	Belongs to the glycosyl hydrolase 31 family
HLK66_15530	COG0395	ABC-type sugar transport system, permease component
HLK66_15535	COG4209	transmembrane transport
HLK66_15550	COG4753	response regulator
HLK66_15550	COG2207	Transcriptional regulator
HLK66_15555	COG2972	Histidine kinase
HLK66_15575	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HLK66_15580	COG0006	proline dipeptidase activity
HLK66_15590	COG3872	metal-dependent enzyme
HLK66_15600	COG1752	Esterase of the alpha-beta hydrolase superfamily
HLK66_15635	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLK66_15640	COG0095	Lipoate-protein ligase
HLK66_15645	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLK66_15650	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HLK66_15655	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HLK66_15660	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HLK66_15665	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HLK66_15700	COG4537	Required for transformation and DNA binding
HLK66_15705	COG1459	type II secretion system
HLK66_15780	COG1705	Flagellar rod assembly protein muramidase FlgJ
HLK66_15885	COG1802	Transcriptional regulator
HLK66_15885	COG4626	Terminase
HLK66_15965	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HLK66_15985	COG1484	DNA-dependent DNA replication
HLK66_16055	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HLK66_16135	COG1705	Flagellar rod assembly protein muramidase FlgJ
HLK66_16320	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HLK66_16340	COG1484	DNA-dependent DNA replication
HLK66_16415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HLK66_16440	COG2072	flavoprotein involved in K transport
HLK66_16455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLK66_16460	COG0011	TIGRFAM Protein of
HLK66_16480	COG1940	carbohydrate kinase activity
HLK66_16505	COG2318	DinB family
HLK66_16520	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HLK66_16525	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HLK66_16555	COG0704	Plays a role in the regulation of phosphate uptake
HLK66_16560	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HLK66_16565	COG0581	inorganic phosphate transmembrane transporter activity
HLK66_16570	COG0573	inorganic phosphate transmembrane transporter activity
HLK66_16575	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HLK66_16590	COG0477	Major facilitator Superfamily
HLK66_16600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLK66_16605	COG2839	Protein conserved in bacteria
HLK66_16610	COG5521	maltodextrose utilization protein MalA
HLK66_16625	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HLK66_16635	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HLK66_16640	COG0735	belongs to the Fur family
HLK66_16650	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HLK66_16655	COG0513	Belongs to the DEAD box helicase family
HLK66_16665	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HLK66_16670	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HLK66_16675	COG2384	SAM-dependent methyltransferase
HLK66_16685	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HLK66_16695	COG1671	Belongs to the UPF0178 family
HLK66_16705	COG0517	IMP dehydrogenase activity
HLK66_16710	COG0751	glycine-tRNA ligase activity
HLK66_16720	COG1381	Involved in DNA repair and RecF pathway recombination
HLK66_16730	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HLK66_16735	COG0295	cytidine deaminase activity
HLK66_16740	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HLK66_16750	COG1480	7TM receptor with intracellular HD hydrolase
HLK66_16755	COG1702	phosphate starvation-inducible protein PhoH
HLK66_16775	COG4864	UPF0365 protein
HLK66_16780	COG1030	water channel activity
HLK66_16785	COG1610	YqeY-like protein
HLK66_16795	COG1283	sodium-dependent phosphate transmembrane transporter activity
HLK66_16810	COG1132	(ABC) transporter
HLK66_16815	COG1132	(ABC) transporter
HLK66_16820	COG2207	Transcriptional regulator
HLK66_16820	COG1917	Cupin 2, conserved barrel domain protein
HLK66_16825	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HLK66_16830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HLK66_16835	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HLK66_16840	COG2264	protein methyltransferase activity
HLK66_16850	COG0443	Heat shock 70 kDa protein
HLK66_16855	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HLK66_16860	COG1420	regulation of RNA biosynthetic process
HLK66_16865	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HLK66_16870	COG0481	GTPase activity
HLK66_16880	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HLK66_16885	COG0268	Binds directly to 16S ribosomal RNA
HLK66_16890	COG1466	dna polymerase III delta subunit
HLK66_16895	COG0658	competence protein
HLK66_16895	COG2333	competence protein COMEC
HLK66_16900	COG2131	deaminase
HLK66_16905	COG1596	polysaccharide export
HLK66_16905	COG1555	photosystem II stabilization
HLK66_16910	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HLK66_16915	COG2226	methyltransferase
HLK66_16920	COG0799	negative regulation of ribosome biogenesis
HLK66_16925	COG1713	HD superfamily hydrolase involved in NAD metabolism
HLK66_16930	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HLK66_16935	COG1534	Rna-binding protein
HLK66_16945	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HLK66_16950	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HLK66_16960	COG0688	phosphatidylethanolamine metabolic process
HLK66_16965	COG1183	phosphatidylcholine synthase activity
HLK66_16980	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLK66_17000	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HLK66_17045	COG4977	sequence-specific DNA binding
HLK66_17060	COG0673	inositol 2-dehydrogenase activity
HLK66_17070	COG0789	Transcriptional regulator
HLK66_17100	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HLK66_17115	COG2801	Transposase and inactivated derivatives
HLK66_17130	COG0626	cystathionine gamma-synthase activity
HLK66_17135	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HLK66_17140	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HLK66_17145	COG2226	methyltransferase
HLK66_17170	COG0768	penicillin binding
HLK66_17175	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HLK66_17180	COG0572	uridine kinase
HLK66_17195	COG4122	O-methyltransferase activity
HLK66_17200	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HLK66_17205	COG3906	Belongs to the UPF0473 family
HLK66_17215	COG4472	Bacterial protein of unknown function (DUF965)
HLK66_17225	COG0628	permease
HLK66_17240	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HLK66_17255	COG1104	cysteine desulfurase activity
HLK66_17260	COG1959	2 iron, 2 sulfur cluster binding
HLK66_17265	COG2364	Membrane
HLK66_17270	COG1473	amidohydrolase
HLK66_17280	COG4948	Mandelate Racemase Muconate Lactonizing
HLK66_17295	COG3833	ABC-type maltose transport systems, permease component
HLK66_17310	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HLK66_17315	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HLK66_17320	COG1131	(ABC) transporter
HLK66_17325	COG1131	(ABC) transporter
HLK66_17330	COG1725	Transcriptional regulator
HLK66_17340	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HLK66_17345	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HLK66_17350	COG0124	histidyl-tRNA synthetase
HLK66_17360	COG4991	sh3 domain protein
HLK66_17360	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLK66_17360	COG3103	Sh3 type 3 domain protein
HLK66_17370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HLK66_17375	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HLK66_17380	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HLK66_17380	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HLK66_17385	COG5416	Lipopolysaccharide assembly protein A domain
HLK66_17390	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HLK66_17390	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HLK66_17400	COG2244	polysaccharide biosynthetic process
HLK66_17405	COG2323	membrane
HLK66_17415	COG3344	reverse transcriptase
HLK66_17420	COG1862	Preprotein translocase
HLK66_17430	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HLK66_17445	COG0632	four-way junction helicase activity
HLK66_17475	COG1827	regulation of RNA biosynthetic process
HLK66_17480	COG0077	Prephenate dehydratase
HLK66_17485	COG4492	Belongs to the UPF0735 family
HLK66_17490	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HLK66_17495	COG3290	protein histidine kinase activity
HLK66_17500	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HLK66_17505	COG2868	ribosomal protein
HLK66_17510	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HLK66_17515	COG1530	ribonuclease E activity
HLK66_17520	COG1994	Peptidase M50
HLK66_17525	COG0739	heme binding
HLK66_17530	COG2894	cell division
HLK66_17535	COG0850	regulation of cytokinetic process
HLK66_17540	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HLK66_17545	COG1792	Involved in formation and maintenance of cell shape
HLK66_17550	COG1077	Cell shape determining protein MreB Mrl
HLK66_17555	COG2003	Belongs to the UPF0758 family
HLK66_17560	COG0424	maF-like protein
HLK66_17590	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HLK66_17610	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HLK66_17650	COG3706	GGDEF domain
HLK66_17660	COG0525	valine-tRNA ligase activity
HLK66_17665	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HLK66_17670	COG1388	LysM domain
HLK66_17670	COG1388	LysM domain
HLK66_17675	COG0726	polysaccharide deacetylase
HLK66_17675	COG1649	PFAM Uncharacterised BCR, COG1649
HLK66_17685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLK66_17695	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HLK66_17700	COG0113	porphobilinogen synthase activity
HLK66_17710	COG0181	hydroxymethylbilane synthase activity
HLK66_17715	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HLK66_17730	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HLK66_17735	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HLK66_17740	COG0470	DNA polymerase III
HLK66_17740	COG1067	ATP-dependent peptidase activity
HLK66_17750	COG0544	peptidyl-prolyl cis-trans isomerase activity
HLK66_17760	COG0066	3-isopropylmalate dehydratase activity
HLK66_17765	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HLK66_17770	COG0473	3-isopropylmalate dehydrogenase activity
HLK66_17775	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HLK66_17780	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HLK66_17785	COG0440	acetolactate synthase activity
HLK66_17790	COG0028	Belongs to the TPP enzyme family
HLK66_17800	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HLK66_17815	COG0622	Phosphoesterase
HLK66_17830	COG5401	PFAM Sporulation and spore germination
HLK66_17835	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HLK66_17840	COG1846	Transcriptional regulator
HLK66_17845	COG2197	response regulator
HLK66_17855	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HLK66_17860	COG1053	succinate dehydrogenase
HLK66_17865	COG2009	succinate dehydrogenase
HLK66_17870	COG1719	4-vinyl reductase, 4VR
HLK66_17885	COG3118	belongs to the thioredoxin family
HLK66_17890	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HLK66_17895	COG2086	electron transfer activity
HLK66_17900	COG0318	PFAM AMP-dependent synthetase and ligase
HLK66_17905	COG3766	membrane
HLK66_17915	COG1796	DNA polymerase
HLK66_17915	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HLK66_17925	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HLK66_17930	COG1940	carbohydrate kinase activity
HLK66_17940	COG0395	ABC-type sugar transport system, permease component
HLK66_17945	COG1175	transmembrane transport
HLK66_17955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLK66_17955	COG0072	phenylalanine-tRNA ligase activity
HLK66_17960	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HLK66_17965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLK66_17975	COG1070	Carbohydrate kinase
HLK66_17980	COG2115	Belongs to the xylose isomerase family
HLK66_17985	COG1940	carbohydrate kinase activity
HLK66_17990	COG0628	permease
HLK66_17995	COG1363	Peptidase, m42
HLK66_18010	COG3326	Membrane
HLK66_18015	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HLK66_18025	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HLK66_18030	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HLK66_18050	COG1484	DNA-dependent DNA replication
HLK66_18055	COG3611	Membrane attachment protein
HLK66_18060	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HLK66_18070	COG1971	Probably functions as a manganese efflux pump
HLK66_18075	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HLK66_18080	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HLK66_18080	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HLK66_18085	COG5002	protein histidine kinase activity
HLK66_18090	COG0745	RESPONSE REGULATOR receiver
HLK66_18095	COG0039	L-malate dehydrogenase activity
HLK66_18100	COG0538	isocitrate dehydrogenase activity
HLK66_18105	COG0372	Belongs to the citrate synthase family
HLK66_18110	COG2707	UPF0756 membrane protein
HLK66_18115	COG0628	permease
HLK66_18165	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_18180	COG0395	ABC-type sugar transport system, permease component
HLK66_18185	COG4209	transmembrane transport
HLK66_18190	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HLK66_18195	COG5578	integral membrane protein
HLK66_18200	COG0395	ABC-type sugar transport system, permease component
HLK66_18205	COG1175	transmembrane transport
HLK66_18210	COG1653	transport
HLK66_18215	COG2207	Transcriptional regulator
HLK66_18220	COG2972	Histidine kinase
HLK66_18225	COG3030	protein affecting phage T7 exclusion by the F plasmid
HLK66_18240	COG0825	malonyl-CoA metabolic process
HLK66_18245	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HLK66_18250	COG2186	Transcriptional regulator
HLK66_18255	COG0587	DNA-directed DNA polymerase activity
HLK66_18270	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HLK66_18275	COG4109	DRTGG domain
HLK66_18285	COG0006	proline dipeptidase activity
HLK66_18300	COG0589	response to stress
HLK66_18305	COG0165	Argininosuccinate lyase
HLK66_18310	COG0137	argininosuccinate synthase activity
HLK66_18315	COG0521	Mo-molybdopterin cofactor biosynthetic process
HLK66_18320	COG3973	AAA domain
HLK66_18335	COG0827	DNA restriction-modification system
HLK66_18340	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HLK66_18345	COG3874	Sporulation protein YtfJ
HLK66_18355	COG1714	RDD family
HLK66_18360	COG0616	signal peptide processing
HLK66_18365	COG2962	Rard protein
HLK66_18370	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HLK66_18375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLK66_18385	COG0301	tRNA thio-modification
HLK66_18390	COG1104	cysteine desulfurase activity
HLK66_18395	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HLK66_18400	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HLK66_18405	COG1309	transcriptional regulator
HLK66_18410	COG1956	GAF domain-containing protein
HLK66_18415	COG2199	diguanylate cyclase activity
HLK66_18415	COG2203	Gaf domain
HLK66_18420	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HLK66_18445	COG1605	Chorismate mutase
HLK66_18445	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HLK66_18450	COG0849	cell division
HLK66_18455	COG3118	belongs to the thioredoxin family
HLK66_18460	COG4980	gas vesicle protein
HLK66_18465	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HLK66_18470	COG2309	aminopeptidase activity
HLK66_18475	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HLK66_18480	COG1674	ftsk spoiiie
HLK66_18485	COG4848	Belongs to the UPF0354 family
HLK66_18490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLK66_18495	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HLK66_18510	COG1363	Peptidase, m42
HLK66_18515	COG5584	Small secreted protein
HLK66_18520	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HLK66_18530	COG0510	thiamine kinase activity
HLK66_18535	COG1523	belongs to the glycosyl hydrolase 13 family
HLK66_18545	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HLK66_18555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLK66_18565	COG1349	DNA-binding transcription factor activity
HLK66_18570	COG1187	pseudouridine synthase activity
HLK66_18575	COG2244	polysaccharide biosynthetic process
HLK66_18580	COG2081	HI0933 family
HLK66_18590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLK66_18595	COG0495	leucyl-tRNA aminoacylation
HLK66_18605	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HLK66_18610	COG0154	amidase activity
HLK66_18615	COG0406	alpha-ribazole phosphatase activity
HLK66_18620	COG2814	Major facilitator Superfamily
HLK66_18635	COG1242	4 iron, 4 sulfur cluster binding
HLK66_18640	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HLK66_18650	COG2267	carboxylic ester hydrolase activity
HLK66_18655	COG4990	cell redox homeostasis
HLK66_18660	COG0367	asparagine synthase
HLK66_18665	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HLK66_18675	COG1506	peptidase
HLK66_18680	COG0494	nUDIX hydrolase
HLK66_18695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLK66_18705	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HLK66_18710	COG0288	reversible hydration of carbon dioxide
HLK66_18730	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HLK66_18735	COG0596	Alpha beta hydrolase
HLK66_18740	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HLK66_18745	COG1169	isochorismate synthase
HLK66_18750	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HLK66_18755	COG0058	SHG alpha-glucan phosphorylase activity
HLK66_18760	COG0297	glycogen (starch) synthase activity
HLK66_18765	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HLK66_18770	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HLK66_18900	COG1285	pathogenesis
HLK66_18920	COG5002	protein histidine kinase activity
HLK66_18935	COG0604	alcohol dehydrogenase
HLK66_18940	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_18945	COG0778	Nitroreductase
HLK66_18955	COG3729	General stress protein
HLK66_18975	COG2059	Chromate
HLK66_18980	COG2059	Chromate
HLK66_18990	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HLK66_18990	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HLK66_18995	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HLK66_18995	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HLK66_19000	COG1309	transcriptional regulator
HLK66_19005	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HLK66_19020	COG1979	alcohol dehydrogenase
HLK66_19025	COG2155	Conserved Protein
HLK66_19030	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HLK66_19035	COG1098	S1 RNA binding domain
HLK66_19040	COG0436	Aminotransferase
HLK66_19045	COG1522	sequence-specific DNA binding
HLK66_19055	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HLK66_19060	COG2011	ABC-type metal ion transport system permease component
HLK66_19065	COG1464	Belongs to the NlpA lipoprotein family
HLK66_19075	COG1914	H( )-stimulated, divalent metal cation uptake system
HLK66_19080	COG2032	superoxide dismutase activity
HLK66_19090	COG5018	Exonuclease
HLK66_19100	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HLK66_19100	COG2111	Na H antiporter
HLK66_19105	COG2111	Na H antiporter
HLK66_19110	COG1006	Multisubunit Na H antiporter MnhC subunit
HLK66_19115	COG0651	ATP synthesis coupled electron transport
HLK66_19120	COG1863	multisubunit Na H antiporter MnhE subunit
HLK66_19125	COG2212	antiporter activity
HLK66_19130	COG1320	monovalent cation:proton antiporter activity
HLK66_19150	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HLK66_19180	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_19190	COG3243	poly(R)-hydroxyalkanoic acid synthase
HLK66_19195	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HLK66_19200	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HLK66_19205	COG3584	3D domain protein
HLK66_19210	COG0492	ferredoxin-NADP+ reductase activity
HLK66_19215	COG0316	Belongs to the HesB IscA family
HLK66_19225	COG4844	belongs to the
HLK66_19235	COG4837	Protein of unknown function (DUF1462)
HLK66_19240	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HLK66_19245	COG0083	homoserine kinase activity
HLK66_19250	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HLK66_19255	COG0460	homoserine dehydrogenase
HLK66_19260	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HLK66_19265	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HLK66_19270	COG0647	UMP catabolic process
HLK66_19275	COG2445	Protein of unknown function DUF86
HLK66_19280	COG3287	FIST C domain
HLK66_19280	COG2199	diguanylate cyclase activity
HLK66_19280	COG2200	EAL domain
HLK66_19290	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HLK66_19295	COG0739	heme binding
HLK66_19300	COG2199	diguanylate cyclase activity
HLK66_19300	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HLK66_19305	COG3377	Domain of unknown function (DUF1805)
HLK66_19310	COG0737	Belongs to the 5'-nucleotidase family
HLK66_19315	COG1801	Protein of unknown function DUF72
HLK66_19320	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_19325	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HLK66_19340	COG1414	Transcriptional regulator
HLK66_19345	COG0561	phosphatase activity
HLK66_19350	COG0110	maltose O-acetyltransferase activity
HLK66_19355	COG0346	lactoylglutathione lyase activity
HLK66_19365	COG1940	carbohydrate kinase activity
HLK66_19370	COG0719	Fe-S assembly protein
HLK66_19375	COG0822	iron-sulfur transferase activity
HLK66_19380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HLK66_19385	COG0719	Fe-S assembly protein
HLK66_19390	COG0396	ATPase activity
HLK66_19395	COG1464	Belongs to the NlpA lipoprotein family
HLK66_19400	COG2011	ABC-type metal ion transport system permease component
HLK66_19405	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HLK66_19415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLK66_19420	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HLK66_19425	COG0509	glycine decarboxylation via glycine cleavage system
HLK66_19430	COG1393	Belongs to the ArsC family
HLK66_19435	COG1960	acyl-CoA dehydrogenase activity
HLK66_19455	COG5577	PFAM Coat F domain
HLK66_19465	COG0772	Belongs to the SEDS family
HLK66_19470	COG0840	transmembrane signaling receptor activity
HLK66_19480	COG1126	abc transporter atp-binding protein
HLK66_19485	COG0765	amino acid transport
HLK66_19490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLK66_19500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLK66_19505	COG1968	undecaprenyl-diphosphatase activity
HLK66_19510	COG0628	permease
HLK66_19515	COG2409	Drug exporters of the RND superfamily
HLK66_19515	COG1033	growth of symbiont in host cell
HLK66_19520	COG1846	Transcriptional regulator
HLK66_19525	COG2050	protein possibly involved in aromatic compounds catabolism
HLK66_19540	COG0366	Alpha amylase catalytic
HLK66_19545	COG1609	Transcriptional regulator
HLK66_19550	COG1733	regulation of RNA biosynthetic process
HLK66_19555	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HLK66_19560	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HLK66_19570	COG3764	Sortase (surface protein transpeptidase)
HLK66_19575	COG1283	sodium-dependent phosphate transmembrane transporter activity
HLK66_19585	COG0488	(ABC) transporter
HLK66_19595	COG1609	Transcriptional regulator
HLK66_19600	COG0673	inositol 2-dehydrogenase activity
HLK66_19605	COG1874	Beta-galactosidase
HLK66_19610	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HLK66_19615	COG0395	ABC-type sugar transport system, permease component
HLK66_19620	COG1175	transmembrane transport
HLK66_19625	COG1653	transport
HLK66_19630	COG2207	Transcriptional regulator
HLK66_19630	COG4753	response regulator
HLK66_19635	COG2972	Histidine kinase
HLK66_19640	COG5578	integral membrane protein
HLK66_19650	COG5577	PFAM Coat F domain
HLK66_19655	COG1366	Belongs to the anti-sigma-factor antagonist family
HLK66_19670	COG1012	belongs to the aldehyde dehydrogenase family
HLK66_19675	COG0710	3-dehydroquinate dehydratase activity
HLK66_19685	COG0753	catalase activity
HLK66_19695	COG0656	L-ascorbic acid biosynthetic process
HLK66_19700	COG0395	ABC-type sugar transport system, permease component
HLK66_19705	COG1175	transmembrane transport
HLK66_19710	COG1653	transport
HLK66_19715	COG1486	melibiose metabolic process
HLK66_19720	COG2207	Transcriptional regulator
HLK66_19730	COG2217	Heavy metal translocating P-type atpase
HLK66_19735	COG2608	mercury ion transmembrane transporter activity
HLK66_19745	COG1802	Transcriptional regulator
HLK66_19755	COG2814	Major facilitator Superfamily
HLK66_19760	COG0789	Transcriptional regulator
HLK66_19765	COG2188	Transcriptional regulator
HLK66_19770	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HLK66_19785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLK66_19815	COG0765	amino acid transport
HLK66_19820	COG1126	abc transporter atp-binding protein
HLK66_19835	COG0395	ABC-type sugar transport system, permease component
HLK66_19840	COG1175	transmembrane transport
HLK66_19845	COG1653	transport
HLK66_19855	COG1012	belongs to the aldehyde dehydrogenase family
HLK66_19865	COG1063	alcohol dehydrogenase
HLK66_19870	COG3775	system Galactitol-specific IIC component
HLK66_19885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_19885	COG3711	transcriptional antiterminator
HLK66_19895	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HLK66_19905	COG1647	Serine aminopeptidase, S33
HLK66_19910	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HLK66_19920	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HLK66_19960	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_19970	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HLK66_19975	COG1660	Displays ATPase and GTPase activities
HLK66_19980	COG1051	belongs to the nudix hydrolase family
HLK66_19995	COG0492	ferredoxin-NADP+ reductase activity
HLK66_20005	COG0457	Tetratricopeptide repeat
HLK66_20010	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HLK66_20010	COG0140	phosphoribosyl-ATP diphosphatase activity
HLK66_20015	COG0107	imidazoleglycerol-phosphate synthase activity
HLK66_20020	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HLK66_20025	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HLK66_20030	COG0131	Imidazoleglycerol-phosphate dehydratase
HLK66_20035	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HLK66_20040	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HLK66_20045	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HLK66_20050	COG0110	maltose O-acetyltransferase activity
HLK66_20055	COG0546	phosphoglycolate phosphatase activity
HLK66_20070	COG1950	PFAM Membrane protein of
HLK66_20075	COG3595	metallopeptidase activity
HLK66_20080	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HLK66_20085	COG0556	nucleotide-excision repair
HLK66_20090	COG4897	Protein conserved in bacteria
HLK66_20095	COG1366	Belongs to the anti-sigma-factor antagonist family
HLK66_20110	COG1454	alcohol dehydrogenase
HLK66_20110	COG1012	belongs to the aldehyde dehydrogenase family
HLK66_20125	COG1595	DNA-templated transcription, initiation
HLK66_20135	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HLK66_20145	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HLK66_20150	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HLK66_20155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLK66_20160	COG2508	Transcriptional regulator
HLK66_20165	COG2233	PERMEase
HLK66_20170	COG0281	malic enzyme
HLK66_20175	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HLK66_20195	COG1053	succinate dehydrogenase
HLK66_20200	COG2030	dehydratase
HLK66_20205	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HLK66_20210	COG4988	ABC transporter
HLK66_20215	COG1294	oxidase, subunit
HLK66_20220	COG1271	oxidase subunit
HLK66_20230	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HLK66_20235	COG0205	6-phosphofructokinase activity
HLK66_20240	COG0698	ribose 5-phosphate isomerase
HLK66_20250	COG1063	alcohol dehydrogenase
HLK66_20255	COG3775	system Galactitol-specific IIC component
HLK66_20260	COG3414	Phosphotransferase system galactitol-specific IIB component
HLK66_20265	COG3414	Phosphotransferase system galactitol-specific IIB component
HLK66_20280	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HLK66_20285	COG0205	6-phosphofructokinase activity
HLK66_20290	COG0698	ribose 5-phosphate isomerase
HLK66_20295	COG0656	L-ascorbic acid biosynthetic process
HLK66_20300	COG2814	Major facilitator Superfamily
HLK66_20305	COG1733	regulation of RNA biosynthetic process
HLK66_20310	COG3409	Peptidoglycan-binding domain 1 protein
HLK66_20310	COG0793	Belongs to the peptidase S41A family
HLK66_20315	COG3546	catalase activity
HLK66_20320	COG2217	Heavy metal translocating P-type atpase
HLK66_20325	COG2217	Heavy metal translocating P-type atpase
HLK66_20335	COG0739	heme binding
HLK66_20340	COG2177	Part of the ABC transporter FtsEX involved in
HLK66_20345	COG2884	Cell division ATP-binding protein ftsE
HLK66_20350	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HLK66_20370	COG0463	Glycosyl transferase, family 2
HLK66_20380	COG0653	protein targeting
HLK66_20400	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HLK66_20405	COG1176	ABC-type spermidine putrescine transport system, permease component I
HLK66_20410	COG3842	ATPase activity
HLK66_20425	COG1802	Transcriptional regulator
HLK66_20430	COG2059	Chromate
HLK66_20435	COG2059	Chromate
HLK66_20440	COG0405	Gamma-glutamyltransferase
HLK66_20455	COG1522	sequence-specific DNA binding
HLK66_20465	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HLK66_20480	COG1516	flagellar protein fliS
HLK66_20485	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HLK66_20490	COG1334	flagellar protein FlaG
HLK66_20510	COG4974	Belongs to the 'phage' integrase family
HLK66_20525	COG4974	Belongs to the 'phage' integrase family
HLK66_20535	COG0653	protein targeting
HLK66_20560	COG4974	Belongs to the 'phage' integrase family
HLK66_20575	COG4974	Belongs to the 'phage' integrase family
HLK66_20595	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HLK66_20600	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HLK66_20610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HLK66_20615	COG4786	Flagellar basal body rod
HLK66_20615	COG1256	bacterial-type flagellum assembly
HLK66_20640	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HLK66_20650	COG1307	EDD domain protein, DegV family
HLK66_20655	COG2197	response regulator
HLK66_20660	COG4585	Histidine kinase
HLK66_20665	COG1739	Uncharacterized protein family UPF0029
HLK66_20670	COG1316	TRANSCRIPTIONal
HLK66_20675	COG2385	sporulation resulting in formation of a cellular spore
HLK66_20675	COG2247	cell wall binding repeat
HLK66_20695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HLK66_20700	COG1442	glycosyl transferase family 8
HLK66_20700	COG1216	Glycosyl transferase, family 2
HLK66_20705	COG1134	teichoic acid transport
HLK66_20710	COG1682	transport, permease protein
HLK66_20715	COG4193	domain, Protein
HLK66_20720	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HLK66_20730	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HLK66_20735	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HLK66_20745	COG0346	lactoylglutathione lyase activity
HLK66_20750	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HLK66_20755	COG0366	Alpha amylase catalytic
HLK66_20760	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HLK66_20775	COG0629	single-stranded DNA binding
HLK66_20780	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLK66_20785	COG4297	protein containing double-stranded beta helix domain
HLK66_20790	COG0840	transmembrane signaling receptor activity
HLK66_20795	COG2814	Major facilitator Superfamily
HLK66_20800	COG1335	isochorismatase
HLK66_20825	COG1012	belongs to the aldehyde dehydrogenase family
HLK66_20840	COG0604	alcohol dehydrogenase
HLK66_20845	COG1660	Displays ATPase and GTPase activities
HLK66_20850	COG0371	Dehydrogenase
HLK66_20855	COG2084	Dehydrogenase
HLK66_20860	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HLK66_20865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLK66_20870	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HLK66_20885	COG3339	Conserved Protein
HLK66_20890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HLK66_20905	COG2011	ABC-type metal ion transport system permease component
HLK66_20910	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HLK66_20920	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HLK66_20925	COG0840	transmembrane signaling receptor activity
HLK66_20930	COG0745	RESPONSE REGULATOR receiver
HLK66_20935	COG0642	Histidine kinase
HLK66_20940	COG1136	(ABC) transporter
HLK66_20945	COG0577	efflux transmembrane transporter activity
HLK66_20960	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HLK66_20965	COG4191	Histidine kinase
HLK66_20990	COG0300	oxidoreductase activity
HLK66_20995	COG0656	L-ascorbic acid biosynthetic process
HLK66_21000	COG0431	NADPH-dependent FMN reductase
HLK66_21000	COG3976	FMN-binding domain protein
HLK66_21000	COG1053	succinate dehydrogenase
HLK66_21010	COG0778	Nitroreductase
HLK66_21015	COG1115	amino acid carrier protein
HLK66_21025	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HLK66_21035	COG0561	phosphatase activity
HLK66_21065	COG1164	Oligoendopeptidase f
HLK66_21070	COG2723	6-phospho-beta-galactosidase activity
HLK66_21075	COG2188	Transcriptional regulator
HLK66_21085	COG0840	transmembrane signaling receptor activity
HLK66_21085	COG5278	phosphoserine phosphatase activity
HLK66_21100	COG1695	Transcriptional regulator
HLK66_21110	COG0191	fructose-bisphosphate aldolase activity
HLK66_21115	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HLK66_21115	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLK66_21115	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLK66_21120	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLK66_21155	COG2124	cytochrome p450
HLK66_21160	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_21165	COG2814	Major facilitator Superfamily
HLK66_21170	COG0383	alpha-mannosidase activity
HLK66_21190	COG2207	Transcriptional regulator
HLK66_21190	COG4753	response regulator
HLK66_21195	COG2972	Histidine kinase
HLK66_21210	COG0395	ABC-type sugar transport system, permease component
HLK66_21215	COG1175	transmembrane transport
HLK66_21220	COG2207	Transcriptional regulator
HLK66_21225	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_21230	COG0477	Major facilitator Superfamily
HLK66_21235	COG1309	transcriptional regulator
HLK66_21240	COG0778	Nitroreductase
HLK66_21245	COG2207	Transcriptional regulator
HLK66_21245	COG4753	response regulator
HLK66_21250	COG2972	Histidine kinase
HLK66_21265	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HLK66_21270	COG0395	ABC-type sugar transport system, permease component
HLK66_21275	COG4209	transmembrane transport
HLK66_21285	COG2188	Transcriptional regulator
HLK66_21290	COG4948	Mandelate Racemase Muconate Lactonizing
HLK66_21295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_21295	COG2190	(PTS) system
HLK66_21295	COG1263	PTS System
HLK66_21305	COG1178	ABC-type Fe3 transport system permease component
HLK66_21310	COG3842	ATPase activity
HLK66_21315	COG1840	ABC-type Fe3 transport system, periplasmic component
HLK66_21320	COG2207	Transcriptional regulator
HLK66_21320	COG4753	response regulator
HLK66_21330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_21330	COG1263	PTS System
HLK66_21350	COG3835	regulator
HLK66_21355	COG1929	Belongs to the glycerate kinase type-1 family
HLK66_21360	COG2610	gluconate transmembrane transporter activity
HLK66_21380	COG1176	ABC-type spermidine putrescine transport system, permease component I
HLK66_21385	COG1176	ABC-type spermidine putrescine transport system, permease component I
HLK66_21390	COG3842	ATPase activity
HLK66_21395	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HLK66_21410	COG0662	Cupin 2, conserved barrel domain protein
HLK66_21410	COG2207	Transcriptional regulator
HLK66_21420	COG4221	oxidoreductase activity
HLK66_21425	COG1595	DNA-templated transcription, initiation
HLK66_21445	COG1988	membrane-bound metal-dependent
HLK66_21450	COG2723	6-phospho-beta-galactosidase activity
HLK66_21455	COG2723	6-phospho-beta-galactosidase activity
HLK66_21460	COG1263	PTS System
HLK66_21460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_21460	COG2190	(PTS) system
HLK66_21470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLK66_21475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLK66_21480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLK66_21485	COG2197	response regulator
HLK66_21490	COG2199	diguanylate cyclase activity
HLK66_21490	COG2200	EAL domain
HLK66_21495	COG3279	Response regulator of the LytR AlgR family
HLK66_21505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLK66_21550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_21555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLK66_21570	COG1316	TRANSCRIPTIONal
HLK66_21575	COG2340	Cysteine-rich secretory protein family
HLK66_21605	COG2153	protein acetylation
HLK66_21620	COG1447	Phosphotransferase system cellobiose-specific component IIA
HLK66_21630	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLK66_21635	COG2723	6-phospho-beta-galactosidase activity
HLK66_21640	COG2188	Transcriptional regulator
HLK66_21645	COG2368	4-hydroxyphenylacetate
HLK66_21675	COG0395	ABC-type sugar transport system, permease component
HLK66_21680	COG1175	transmembrane transport
HLK66_21690	COG1940	carbohydrate kinase activity
HLK66_21695	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HLK66_21715	COG2720	vancomycin resistance protein
HLK66_21720	COG0346	lactoylglutathione lyase activity
HLK66_21735	COG1609	Transcriptional regulator
HLK66_21750	COG2160	L-arabinose isomerase activity
HLK66_21790	COG2079	MmgE PrpD family protein
HLK66_21795	COG1473	amidohydrolase
HLK66_21800	COG1126	abc transporter atp-binding protein
HLK66_21805	COG0765	amino acid transport
HLK66_21810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLK66_21815	COG0456	acetyltransferase
HLK66_21825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLK66_21830	COG0436	Aminotransferase
HLK66_21835	COG0371	Dehydrogenase
HLK66_21850	COG4895	conserved protein (DUF2196)
HLK66_21870	COG1846	Transcriptional regulator
HLK66_21880	COG2814	Major facilitator Superfamily
HLK66_21885	COG0395	ABC-type sugar transport system, permease component
HLK66_21890	COG1175	transmembrane transport
HLK66_21900	COG0165	Argininosuccinate lyase
HLK66_21920	COG0840	transmembrane signaling receptor activity
HLK66_21930	COG3344	reverse transcriptase
HLK66_21940	COG1012	belongs to the aldehyde dehydrogenase family
HLK66_21945	COG2188	Transcriptional regulator
HLK66_21950	COG2222	sugar isomerase
HLK66_21955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLK66_21960	COG1082	Xylose isomerase domain protein TIM barrel
HLK66_21965	COG1126	abc transporter atp-binding protein
HLK66_21970	COG0765	amino acid transport
HLK66_21995	COG0395	ABC-type sugar transport system, permease component
HLK66_22000	COG4209	transmembrane transport
HLK66_22010	COG3279	Response regulator of the LytR AlgR family
HLK66_22015	COG2972	Histidine kinase
HLK66_22020	COG0800	Aldolase
HLK66_22025	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HLK66_22035	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HLK66_22040	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_22040	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_22060	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HLK66_22100	COG1131	(ABC) transporter
HLK66_22105	COG2205	protein histidine kinase activity
HLK66_22110	COG0745	RESPONSE REGULATOR receiver
HLK66_22115	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HLK66_22125	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HLK66_22130	COG3716	PTS system mannose fructose sorbose family IID component
HLK66_22135	COG3715	PTS system
HLK66_22145	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_22145	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_22150	COG1940	carbohydrate kinase activity
HLK66_22150	COG1846	Transcriptional regulator
HLK66_22155	COG3328	transposase activity
HLK66_22165	COG4821	SIS domain
HLK66_22175	COG1402	creatininase
HLK66_22195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_22200	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_22210	COG1141	Ferredoxin
HLK66_22215	COG0402	S-adenosylhomocysteine deaminase activity
HLK66_22220	COG0402	S-adenosylhomocysteine deaminase activity
HLK66_22230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLK66_22260	COG1522	sequence-specific DNA binding
HLK66_22285	COG1263	PTS System
HLK66_22285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_22285	COG2190	(PTS) system
HLK66_22335	COG1940	carbohydrate kinase activity
HLK66_22340	COG2188	Transcriptional regulator
HLK66_22350	COG4821	SIS domain
HLK66_22380	COG0543	2 iron, 2 sulfur cluster binding
HLK66_22385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLK66_22395	COG2814	Major facilitator Superfamily
HLK66_22410	COG0679	Auxin Efflux Carrier
HLK66_22415	COG0281	malic enzyme
HLK66_22445	COG0402	S-adenosylhomocysteine deaminase activity
HLK66_22455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_22455	COG2190	(PTS) system
HLK66_22455	COG1263	PTS System
HLK66_22465	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HLK66_22470	COG1609	Transcriptional regulator
HLK66_22510	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HLK66_22525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_22560	COG2801	Transposase and inactivated derivatives
HLK66_22595	COG1091	dTDP-4-dehydrorhamnose reductase activity
HLK66_22630	COG1215	transferase activity, transferring glycosyl groups
HLK66_22640	COG0110	maltose O-acetyltransferase activity
HLK66_22655	COG4464	protein tyrosine phosphatase activity
HLK66_22660	COG0489	protein tyrosine kinase activity
HLK66_22665	COG3944	biosynthesis protein
HLK66_22675	COG1396	sequence-specific DNA binding
HLK66_22685	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HLK66_22700	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HLK66_22700	COG0662	Cupin 2, conserved barrel domain protein
HLK66_22705	COG1132	(ABC) transporter
HLK66_22730	COG0438	transferase activity, transferring glycosyl groups
HLK66_22740	COG5039	Polysaccharide pyruvyl transferase
HLK66_22745	COG1216	Glycosyl transferase, family 2
HLK66_22745	COG1442	glycosyl transferase family 8
HLK66_22775	COG0438	transferase activity, transferring glycosyl groups
HLK66_22785	COG0438	transferase activity, transferring glycosyl groups
HLK66_22795	COG0438	transferase activity, transferring glycosyl groups
HLK66_22800	COG1215	transferase activity, transferring glycosyl groups
HLK66_22805	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HLK66_22810	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HLK66_22815	COG0489	protein tyrosine kinase activity
HLK66_22820	COG3944	biosynthesis protein
HLK66_22825	COG0668	transmembrane transport
HLK66_22850	COG2814	Major facilitator Superfamily
HLK66_22855	COG4978	Transcriptional regulator
HLK66_22855	COG0789	Transcriptional regulator
HLK66_22865	COG1846	Transcriptional regulator
HLK66_22870	COG1132	(ABC) transporter
HLK66_22890	COG3119	arylsulfatase activity
HLK66_22895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_22895	COG1263	PTS System
HLK66_22895	COG2190	(PTS) system
HLK66_22900	COG3711	transcriptional antiterminator
HLK66_22905	COG2190	(PTS) system
HLK66_22910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_22910	COG3711	transcriptional antiterminator
HLK66_22920	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLK66_22925	COG1447	Phosphotransferase system cellobiose-specific component IIA
HLK66_22930	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLK66_22950	COG2002	toxin-antitoxin pair type II binding
HLK66_22955	COG3706	GGDEF domain
HLK66_22960	COG1742	UPF0060 membrane protein
HLK66_22980	COG1846	Transcriptional regulator
HLK66_22985	COG1566	PFAM secretion protein HlyD family protein
HLK66_22990	COG2814	Major facilitator Superfamily
HLK66_23000	COG0673	inositol 2-dehydrogenase activity
HLK66_23010	COG2814	Major facilitator Superfamily
HLK66_23015	COG0596	Alpha beta hydrolase
HLK66_23020	COG1309	transcriptional regulator
HLK66_23030	COG0667	Aldo Keto reductase
HLK66_23035	COG1940	carbohydrate kinase activity
HLK66_23040	COG2723	6-phospho-beta-galactosidase activity
HLK66_23050	COG3458	cephalosporin-C deacetylase activity
HLK66_23055	COG1609	Transcriptional regulator
HLK66_23060	COG0701	Predicted permease
HLK66_23065	COG0709	Synthesizes selenophosphate from selenide and ATP
HLK66_23070	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HLK66_23080	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HLK66_23085	COG1388	LysM domain
HLK66_23090	COG4191	Histidine kinase
HLK66_23095	COG0025	NhaP-type Na H and K H
HLK66_23125	COG1408	metallophosphoesterase
HLK66_23135	COG2197	response regulator
HLK66_23140	COG4585	Histidine kinase
HLK66_23145	COG0842	Transport permease protein
HLK66_23150	COG1131	(ABC) transporter
HLK66_23175	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HLK66_23180	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_23190	COG0697	spore germination
HLK66_23195	COG1388	LysM domain
HLK66_23195	COG0791	NLP P60 protein
HLK66_23200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HLK66_23205	COG5522	Integral membrane protein (intg_mem_TP0381)
HLK66_23215	COG0460	homoserine dehydrogenase
HLK66_23230	COG2719	SpoVR family
HLK66_23235	COG0768	penicillin binding
HLK66_23240	COG3011	Protein conserved in bacteria
HLK66_23250	COG0791	NLP P60 protein
HLK66_23250	COG1388	LysM domain
HLK66_23255	COG4715	Zinc finger, swim domain protein
HLK66_23260	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HLK66_23290	COG4786	Flagellar basal body rod
HLK66_23295	COG4786	Flagellar basal body rod
HLK66_23300	COG1077	Cell shape determining protein MreB Mrl
HLK66_23305	COG1609	Transcriptional regulator
HLK66_23310	COG0739	heme binding
HLK66_23320	COG2385	sporulation resulting in formation of a cellular spore
HLK66_23325	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HLK66_23335	COG4836	Membrane
HLK66_23340	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HLK66_23345	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HLK66_23350	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HLK66_23360	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HLK66_23365	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HLK66_23370	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HLK66_23375	COG0356	it plays a direct role in the translocation of protons across the membrane
HLK66_23385	COG1404	Belongs to the peptidase S8 family
HLK66_23390	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HLK66_23395	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HLK66_23405	COG0840	transmembrane signaling receptor activity
HLK66_23415	COG1971	Probably functions as a manganese efflux pump
HLK66_23420	COG0009	L-threonylcarbamoyladenylate synthase
HLK66_23430	COG2204	response regulator
HLK66_23440	COG1012	belongs to the aldehyde dehydrogenase family
HLK66_23445	COG0506	proline dehydrogenase activity
HLK66_23450	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLK66_23455	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLK66_23455	COG1321	iron dependent repressor
HLK66_23460	COG1121	(ABC) transporter
HLK66_23465	COG0803	Belongs to the bacterial solute-binding protein 9 family
HLK66_23480	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HLK66_23485	COG1366	Belongs to the anti-sigma-factor antagonist family
HLK66_23490	COG1253	flavin adenine dinucleotide binding
HLK66_23495	COG1253	flavin adenine dinucleotide binding
HLK66_23515	COG1435	thymidine kinase activity
HLK66_23525	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HLK66_23535	COG0191	fructose-bisphosphate aldolase activity
HLK66_23540	COG2204	response regulator
HLK66_23545	COG4821	SIS domain
HLK66_23550	COG0504	CTP synthase activity
HLK66_23555	COG3343	RNA polymerase activity
HLK66_23565	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLK66_23575	COG3279	Response regulator of the LytR AlgR family
HLK66_23580	COG4555	ABC transporter
HLK66_23585	COG1668	transmembrane transport
HLK66_23595	COG1131	(ABC) transporter
HLK66_23620	COG0018	arginyl-trna synthetase
HLK66_23625	COG4506	Protein conserved in bacteria
HLK66_23630	COG3103	Sh3 type 3 domain protein
HLK66_23630	COG0791	NLP P60 protein
HLK66_23630	COG1388	LysM domain
HLK66_23635	COG0010	Belongs to the arginase family
HLK66_23640	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HLK66_23645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLK66_23655	COG1193	negative regulation of DNA recombination
HLK66_23665	COG1994	Peptidase M50
HLK66_23670	COG1942	4-Oxalocrotonate Tautomerase
HLK66_23675	COG3465	dGTPase activity
HLK66_23680	COG1078	dGTPase activity
HLK66_23690	COG0477	Major facilitator Superfamily
HLK66_23705	COG0280	phosphate acetyltransferase
HLK66_23720	COG2363	Small membrane protein
HLK66_23735	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HLK66_23750	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HLK66_23760	COG0314	molybdopterin synthase activity
HLK66_23765	COG0351	phosphomethylpyrimidine kinase
HLK66_23770	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HLK66_23790	COG0561	phosphatase activity
HLK66_23795	COG1271	oxidase subunit
HLK66_23800	COG1294	oxidase, subunit
HLK66_23805	COG4988	ABC transporter
HLK66_23810	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HLK66_23815	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HLK66_23820	COG2226	methyltransferase
HLK66_23825	COG0492	ferredoxin-NADP+ reductase activity
HLK66_23830	COG1486	melibiose metabolic process
HLK66_23835	COG3610	response to peptide
HLK66_23840	COG2966	Psort location CytoplasmicMembrane, score
HLK66_23860	COG1131	(ABC) transporter
HLK66_23865	COG0686	Belongs to the AlaDH PNT family
HLK66_23870	COG2508	Transcriptional regulator
HLK66_23870	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HLK66_23880	COG1486	melibiose metabolic process
HLK66_23885	COG1447	Phosphotransferase system cellobiose-specific component IIA
HLK66_23890	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLK66_23895	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLK66_23900	COG2188	Transcriptional regulator
HLK66_23910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLK66_23915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLK66_23925	COG0385	Bile acid
HLK66_23930	COG1447	Phosphotransferase system cellobiose-specific component IIA
HLK66_23935	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLK66_23940	COG2723	6-phospho-beta-galactosidase activity
HLK66_23950	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_23950	COG3711	transcriptional antiterminator
HLK66_23960	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLK66_24010	COG2508	Transcriptional regulator
HLK66_24020	COG0477	Major facilitator Superfamily
HLK66_24025	COG0534	Mate efflux family protein
HLK66_24035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLK66_24045	COG1609	Transcriptional regulator
HLK66_24060	COG1609	Transcriptional regulator
HLK66_24070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLK66_24075	COG1554	hydrolase, family 65, central catalytic
HLK66_24085	COG3833	ABC-type maltose transport systems, permease component
HLK66_24090	COG1175	transmembrane transport
HLK66_24095	COG2182	Extracellular solute-binding protein
HLK66_24100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLK66_24100	COG1263	PTS System
HLK66_24105	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HLK66_24110	COG1122	ATPase activity
HLK66_24115	COG4721	ABC-type cobalt transport system, permease component
HLK66_24120	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HLK66_24130	COG3695	enzyme binding
HLK66_24140	COG0411	ABC transporter
HLK66_24170	COG0492	ferredoxin-NADP+ reductase activity
HLK66_24180	COG4176	ABC-type proline glycine betaine transport system permease component
HLK66_24190	COG3507	Belongs to the glycosyl hydrolase 43 family
HLK66_24205	COG1073	alpha beta
HLK66_24215	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HLK66_24220	COG1653	transport
HLK66_24230	COG4209	transmembrane transport
HLK66_24235	COG0395	ABC-type sugar transport system, permease component
HLK66_24240	COG2207	Transcriptional regulator
HLK66_24250	COG2721	sulfolactate sulfo-lyase activity
HLK66_24255	COG1904	glucuronate isomerase
HLK66_24260	COG0657	acetylesterase activity
HLK66_24260	COG2755	lipolytic protein G-D-S-L family
HLK66_24265	COG2755	lipolytic protein G-D-S-L family
HLK66_24280	COG2814	Major facilitator Superfamily
HLK66_24310	COG2072	flavoprotein involved in K transport
HLK66_24345	COG2208	phosphoserine phosphatase activity
HLK66_24350	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HLK66_24355	COG2205	protein histidine kinase activity
HLK66_24355	COG2198	Histidine kinase
HLK66_24355	COG0784	Response regulator, receiver
HLK66_24365	COG4608	Belongs to the ABC transporter superfamily
HLK66_24370	COG0444	Belongs to the ABC transporter superfamily
HLK66_24375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLK66_24380	COG0601	transmembrane transport
HLK66_24385	COG4166	transmembrane transport
HLK66_24395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLK66_24400	COG4989	oxidoreductase activity
HLK66_24405	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HLK66_24410	COG1320	monovalent cation:proton antiporter activity
HLK66_24415	COG2212	antiporter activity
HLK66_24420	COG1863	multisubunit Na H antiporter MnhE subunit
HLK66_24425	COG0651	ATP synthesis coupled electron transport
HLK66_24435	COG2111	Na H antiporter
HLK66_24450	COG0582	viral genome integration into host DNA
HLK66_24455	COG0124	histidyl-tRNA synthetase
HLK66_24460	COG3142	Participates in the control of copper homeostasis
HLK66_24465	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HLK66_24470	COG1609	Transcriptional regulator
HLK66_24475	COG3459	Glycosyltransferase 36 associated
HLK66_24485	COG0395	ABC-type sugar transport system, permease component
HLK66_24490	COG1175	transmembrane transport
HLK66_24500	COG5039	Polysaccharide pyruvyl transferase
HLK66_24505	COG1994	Peptidase M50
HLK66_24510	COG1397	ADP-ribosylglycohydrolase
HLK66_24535	COG4555	ABC transporter
HLK66_24545	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLK66_24550	COG0450	alkyl hydroperoxide reductase
HLK66_24555	COG3634	alkyl hydroperoxide reductase activity
HLK66_24575	COG4166	transmembrane transport
HLK66_24580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLK66_24580	COG3711	transcriptional antiterminator
HLK66_24585	COG2723	6-phospho-beta-galactosidase activity
HLK66_24595	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLK66_24600	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLK66_24605	COG3507	Belongs to the glycosyl hydrolase 43 family
HLK66_24610	COG0579	oxidoreductase
HLK66_24615	COG1464	Belongs to the NlpA lipoprotein family
HLK66_24625	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HLK66_24630	COG1279	arginine transmembrane transporter activity
HLK66_24635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLK66_24645	COG5566	PFAM Mor transcription activator
HLK66_24650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLK66_24655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLK66_24665	COG5002	protein histidine kinase activity
HLK66_24685	COG2824	Alkylphosphonate utilization operon protein PhnA
HLK66_24695	COG0840	transmembrane signaling receptor activity
HLK66_24700	COG1126	abc transporter atp-binding protein
HLK66_24705	COG0765	amino acid transport
HLK66_24715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLK66_24720	COG2814	Major facilitator Superfamily
HLK66_24730	COG0733	neurotransmitter:sodium symporter activity
HLK66_24740	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HLK66_24745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HLK66_24750	COG1696	Membrane protein involved in D-alanine export
HLK66_24755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HLK66_24765	COG0745	RESPONSE REGULATOR receiver
HLK66_24770	COG5002	protein histidine kinase activity
HLK66_24780	COG0697	spore germination
HLK66_24785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLK66_24795	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HLK66_24800	COG2169	Transcriptional regulator
HLK66_24810	COG1126	abc transporter atp-binding protein
HLK66_24815	COG0765	amino acid transport
HLK66_24820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLK66_24855	COG2223	nitrite transmembrane transporter activity
HLK66_24860	COG0109	protoheme IX farnesyltransferase activity
HLK66_24865	COG0746	molybdenum cofactor guanylyltransferase activity
HLK66_24870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLK66_24875	COG1763	Mo-molybdopterin cofactor biosynthetic process
HLK66_24885	COG0314	molybdopterin synthase activity
HLK66_24890	COG0303	'Molybdopterin
HLK66_24895	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HLK66_24900	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HLK66_24910	COG2181	nitrate reductase activity
HLK66_24915	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HLK66_24920	COG1140	nitrate reductase beta subunit
HLK66_24925	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HLK66_24930	COG4149	molybdate abc transporter
HLK66_24935	COG0725	ABC transporter, periplasmic molybdate-binding protein
HLK66_24950	COG1028	Short-chain dehydrogenase reductase Sdr
HLK66_24960	COG0697	spore germination
HLK66_24965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLK66_25015	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HLK66_25065	COG4974	Belongs to the 'phage' integrase family
HLK66_25075	COG1201	RNA secondary structure unwinding
HLK66_25105	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HLK66_25125	COG1074	ATP-dependent DNA helicase activity
HLK66_25145	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HLK66_25155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLK66_25160	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HLK66_25165	COG4853	Protein conserved in bacteria
HLK66_25170	COG4863	YycH protein
HLK66_25175	COG5002	protein histidine kinase activity
HLK66_25180	COG0745	RESPONSE REGULATOR receiver
HLK66_25210	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HLK66_25225	COG0305	Participates in initiation and elongation during chromosome replication
HLK66_25230	COG0359	binds to the 23S rRNA
HLK66_25235	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HLK66_25250	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HLK66_25260	COG0360	Binds together with S18 to 16S ribosomal RNA
HLK66_25265	COG0438	transferase activity, transferring glycosyl groups
HLK66_25270	COG0012	GTP binding
HLK66_25275	COG4481	Protein conserved in bacteria
HLK66_25280	COG0668	transmembrane transport
HLK66_25290	COG1475	DNA binding
HLK66_25295	COG1192	Involved in chromosome partitioning
HLK66_25300	COG1475	DNA binding
HLK66_25320	COG1847	R3H domain protein
HLK66_25330	COG0594	ribonuclease P activity
HLK66_25335	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HLK66_25365	COG1414	Transcriptional regulator
HLK66_25370	COG2814	Major facilitator Superfamily
HLK66_25380	COG2329	Antibiotic biosynthesis monooxygenase
HLK66_25405	COG0697	spore germination
HLK66_25435	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HLK66_25440	COG0640	Transcriptional regulator
HLK66_25445	COG0640	Transcriptional regulator
HLK66_25455	COG0492	ferredoxin-NADP+ reductase activity
HLK66_25465	COG1846	Transcriptional regulator
HLK66_25515	COG4712	double-strand break repair protein
HLK66_25520	COG0592	DNA-directed DNA polymerase activity
HLK66_25705	COG0583	DNA-binding transcription factor activity
HLK66_25715	COG2135	peptidase activity
HLK66_25760	COG0629	single-stranded DNA binding
HLK66_25785	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HLK66_25825	COG3344	reverse transcriptase
HLK66_26065	COG1525	nuclease
HLK66_26100	COG3883	PFAM NLP P60 protein
HLK66_26100	COG0791	NLP P60 protein
HLK66_26165	COG4974	Belongs to the 'phage' integrase family
HLK66_26180	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HLK66_26195	COG1793	dna ligase