locus-tag	class	description
C2I06_00005	COG0189	ligase activity
C2I06_00025	COG0561	phosphatase activity
C2I06_00030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2I06_00035	COG2252	PERMEase
C2I06_00040	COG4152	abc transporter atp-binding protein
C2I06_00045	COG1668	transmembrane transport
C2I06_00050	COG0420	3'-5' exonuclease activity
C2I06_00055	COG4717	serine-type aminopeptidase activity
C2I06_00090	COG1846	Transcriptional regulator
C2I06_00100	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C2I06_00105	COG0537	adenosine 5'-monophosphoramidase activity
C2I06_00110	COG1131	(ABC) transporter
C2I06_00115	COG4473	ABC transporter
C2I06_00125	COG1473	amidohydrolase
C2I06_00135	COG3069	C4-dicarboxylate transmembrane transporter activity
C2I06_00145	COG4585	Histidine kinase
C2I06_00150	COG2197	response regulator
C2I06_00160	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C2I06_00170	COG1309	transcriptional regulator
C2I06_00175	COG1511	domain protein
C2I06_00180	COG0095	Lipoate-protein ligase
C2I06_00185	COG0501	Belongs to the peptidase M48B family
C2I06_00205	COG1506	peptidase
C2I06_00205	COG4946	Tricorn protease homolog
C2I06_00205	COG0823	Involved in the tonB-independent uptake of proteins
C2I06_00210	COG1316	TRANSCRIPTIONal
C2I06_00215	COG0398	Pfam SNARE associated Golgi protein
C2I06_00225	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C2I06_00270	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2I06_00280	COG4585	Histidine kinase
C2I06_00290	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I06_00295	COG1253	flavin adenine dinucleotide binding
C2I06_00300	COG1131	(ABC) transporter
C2I06_00315	COG2226	methyltransferase
C2I06_00320	COG1131	(ABC) transporter
C2I06_00330	COG1737	Transcriptional regulator
C2I06_00335	COG0673	inositol 2-dehydrogenase activity
C2I06_00340	COG0673	inositol 2-dehydrogenase activity
C2I06_00350	COG2207	Transcriptional regulator
C2I06_00350	COG0662	Cupin 2, conserved barrel domain protein
C2I06_00365	COG1247	-acetyltransferase
C2I06_00375	COG0367	asparagine synthase
C2I06_00385	COG0697	spore germination
C2I06_00395	COG1028	Short-chain dehydrogenase reductase Sdr
C2I06_00400	COG1666	GTP binding
C2I06_00405	COG2996	Protein conserved in bacteria
C2I06_00420	COG1307	EDD domain protein, DegV family
C2I06_00425	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I06_00440	COG0561	phosphatase activity
C2I06_00445	COG1073	alpha beta
C2I06_00450	COG2151	metal-sulfur cluster biosynthetic enzyme
C2I06_00455	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2I06_00460	COG0303	'Molybdopterin
C2I06_00465	COG1620	l-lactate permease
C2I06_00470	COG2186	Transcriptional regulator
C2I06_00475	COG0247	lactate metabolic process
C2I06_00480	COG1139	Iron-sulfur cluster binding protein
C2I06_00485	COG1556	Lactate utilization protein
C2I06_00490	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C2I06_00495	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C2I06_00500	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2I06_00520	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C2I06_00540	COG2267	carboxylic ester hydrolase activity
C2I06_00550	COG1744	ABC transporter substrate-binding protein PnrA-like
C2I06_00560	COG3711	transcriptional antiterminator
C2I06_00570	COG3730	PTS system glucitol sorbitol-specific
C2I06_00575	COG3732	PTS system glucitol sorbitol-specific
C2I06_00590	COG0561	phosphatase activity
C2I06_00600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2I06_00605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2I06_00610	COG0735	belongs to the Fur family
C2I06_00615	COG5504	Zn-dependent protease
C2I06_00625	COG0180	Tryptophanyl-tRNA synthetase
C2I06_00630	COG4166	transmembrane transport
C2I06_00635	COG0601	transmembrane transport
C2I06_00640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2I06_00645	COG0444	Belongs to the ABC transporter superfamily
C2I06_00655	COG0456	acetyltransferase
C2I06_00660	COG1393	Belongs to the ArsC family
C2I06_00665	COG4862	establishment of competence for transformation
C2I06_00670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2I06_00680	COG1164	Oligoendopeptidase f
C2I06_00690	COG2346	COG2346, Truncated hemoglobins
C2I06_00695	COG0741	lytic transglycosylase activity
C2I06_00700	COG4116	CYTH
C2I06_00710	COG2357	RelA SpoT domain protein
C2I06_00715	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C2I06_00720	COG0564	pseudouridine synthase activity
C2I06_00725	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2I06_00730	COG2239	Acts as a magnesium transporter
C2I06_00735	COG0569	domain protein
C2I06_00735	COG0475	glutathione-regulated potassium exporter activity
C2I06_00740	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2I06_00770	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2I06_00790	COG0210	DNA helicase
C2I06_00800	COG2323	membrane
C2I06_00805	COG2153	protein acetylation
C2I06_00810	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C2I06_00815	COG2382	esterase
C2I06_00820	COG1328	CTP reductase activity
C2I06_00825	COG0602	queuosine metabolic process
C2I06_00835	COG0431	NADPH-dependent FMN reductase
C2I06_00850	COG0726	polysaccharide deacetylase
C2I06_00865	COG1737	Transcriptional regulator
C2I06_00870	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C2I06_00880	COG1070	Carbohydrate kinase
C2I06_00890	COG2169	Transcriptional regulator
C2I06_00895	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C2I06_00900	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2I06_00905	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
C2I06_00910	COG1215	transferase activity, transferring glycosyl groups
C2I06_00915	COG1609	Transcriptional regulator
C2I06_00920	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2I06_00925	COG0363	glucosamine-6-phosphate deaminase activity
C2I06_00935	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C2I06_00940	COG1595	DNA-templated transcription, initiation
C2I06_00945	COG3104	oligopeptide transport
C2I06_00960	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2I06_00970	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2I06_00980	COG1028	Short-chain dehydrogenase reductase Sdr
C2I06_00980	COG3347	Dehydrogenase
C2I06_00995	COG1070	Carbohydrate kinase
C2I06_01000	COG4806	L-rhamnose isomerase
C2I06_01010	COG2972	Histidine kinase
C2I06_01030	COG4214	carbohydrate transport
C2I06_01035	COG1349	DNA-binding transcription factor activity
C2I06_01045	COG1366	Belongs to the anti-sigma-factor antagonist family
C2I06_01050	COG0366	Alpha amylase catalytic
C2I06_01055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I06_01055	COG1263	PTS System
C2I06_01055	COG2190	(PTS) system
C2I06_01060	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C2I06_01070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2I06_01095	COG1216	Glycosyl transferase, family 2
C2I06_01100	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C2I06_01105	COG3541	Predicted nucleotidyltransferase
C2I06_01115	COG1834	amidinotransferase
C2I06_01120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2I06_01125	COG1309	transcriptional regulator
C2I06_01130	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2I06_01135	COG1523	belongs to the glycosyl hydrolase 13 family
C2I06_01150	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2I06_01155	COG1937	Protein conserved in bacteria
C2I06_01160	COG2210	Belongs to the sulfur carrier protein TusA family
C2I06_01165	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2I06_01180	COG5577	PFAM Coat F domain
C2I06_01190	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2I06_01195	COG3162	membrane
C2I06_01200	COG3546	catalase activity
C2I06_01205	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2I06_01240	COG2205	protein histidine kinase activity
C2I06_01245	COG0745	RESPONSE REGULATOR receiver
C2I06_01275	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2I06_01280	COG0840	transmembrane signaling receptor activity
C2I06_01285	COG0655	NAD(P)H dehydrogenase (quinone) activity
C2I06_01290	COG3279	Response regulator of the LytR AlgR family
C2I06_01295	COG2972	Histidine kinase
C2I06_01305	COG1175	transmembrane transport
C2I06_01335	COG2814	Major facilitator Superfamily
C2I06_01340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I06_01345	COG1116	anion transmembrane transporter activity
C2I06_01350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2I06_01355	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2I06_01360	COG0697	spore germination
C2I06_01365	COG1609	Transcriptional regulator
C2I06_01370	COG4209	transmembrane transport
C2I06_01375	COG0395	ABC-type sugar transport system, permease component
C2I06_01385	COG1621	beta-fructofuranosidase activity
C2I06_01390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2I06_01395	COG1621	beta-fructofuranosidase activity
C2I06_01400	COG1621	beta-fructofuranosidase activity
C2I06_01405	COG1621	beta-fructofuranosidase activity
C2I06_01410	COG1653	transport
C2I06_01415	COG4753	response regulator
C2I06_01415	COG2207	Transcriptional regulator
C2I06_01420	COG2972	Histidine kinase
C2I06_01425	COG0583	DNA-binding transcription factor activity
C2I06_01430	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2I06_01435	COG2271	Major facilitator Superfamily
C2I06_01440	COG0405	Gamma-glutamyltransferase
C2I06_01445	COG0840	transmembrane signaling receptor activity
C2I06_01455	COG0494	nUDIX hydrolase
C2I06_01460	COG2723	6-phospho-beta-galactosidase activity
C2I06_01465	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2I06_01470	COG2146	nitrite reductase [NAD(P)H] activity
C2I06_01475	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2I06_01475	COG1587	Uroporphyrinogen-III synthase
C2I06_01485	COG2116	formate transmembrane transporter activity
C2I06_01490	COG3604	Transcriptional regulator
C2I06_01530	COG0523	cobalamin synthesis protein
C2I06_01535	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C2I06_01545	COG3588	fructose-bisphosphate aldolase
C2I06_01580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2I06_01590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I06_01600	COG1175	transmembrane transport
C2I06_01605	COG0395	ABC-type sugar transport system, permease component
C2I06_01615	COG0673	inositol 2-dehydrogenase activity
C2I06_01625	COG0673	inositol 2-dehydrogenase activity
C2I06_01635	COG1082	Xylose isomerase domain protein TIM barrel
C2I06_01640	COG3773	Cell wall hydrolase
C2I06_01645	COG0515	serine threonine protein kinase
C2I06_01655	COG1732	Glycine betaine
C2I06_01665	COG2207	Transcriptional regulator
C2I06_01665	COG0662	Cupin 2, conserved barrel domain protein
C2I06_01680	COG0395	ABC-type sugar transport system, permease component
C2I06_01685	COG1874	Beta-galactosidase
C2I06_01690	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2I06_01695	COG3773	Cell wall hydrolase
C2I06_01705	COG1414	Transcriptional regulator
C2I06_01710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2I06_01715	COG0129	dihydroxy-acid dehydratase activity
C2I06_01725	COG3507	Belongs to the glycosyl hydrolase 43 family
C2I06_01735	COG0583	DNA-binding transcription factor activity
C2I06_01745	COG1811	Na channel or pump
C2I06_01755	COG3842	ATPase activity
C2I06_01775	COG0584	glycerophosphoryl diester phosphodiesterase
C2I06_01780	COG0584	glycerophosphoryl diester phosphodiesterase
C2I06_01795	COG0142	geranyltranstransferase activity
C2I06_01800	COG1234	tRNA 3'-trailer cleavage
C2I06_01830	COG2508	Transcriptional regulator
C2I06_01835	COG1953	Uracil, thiamine, allantoin
C2I06_01855	COG1266	CAAX protease self-immunity
C2I06_01865	COG0720	synthase
C2I06_01875	COG0302	gtp cyclohydrolase
C2I06_01885	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2I06_01910	COG0431	NADPH-dependent FMN reductase
C2I06_01925	COG0395	ABC-type sugar transport system, permease component
C2I06_01930	COG3507	Belongs to the glycosyl hydrolase 43 family
C2I06_01935	COG5578	integral membrane protein
C2I06_01940	COG3940	Belongs to the glycosyl hydrolase 43 family
C2I06_01965	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2I06_01970	COG2207	Transcriptional regulator
C2I06_01980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2I06_01995	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C2I06_02000	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C2I06_02005	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2I06_02015	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2I06_02020	COG1113	amino acid transport
C2I06_02025	COG4555	ABC transporter
C2I06_02055	COG0745	RESPONSE REGULATOR receiver
C2I06_02060	COG3850	Histidine kinase
C2I06_02060	COG5002	protein histidine kinase activity
C2I06_02065	COG1136	(ABC) transporter
C2I06_02075	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2I06_02080	COG1012	belongs to the aldehyde dehydrogenase family
C2I06_02085	COG1595	DNA-templated transcription, initiation
C2I06_02105	COG0366	Alpha amylase catalytic
C2I06_02110	COG2017	converts alpha-aldose to the beta-anomer
C2I06_02115	COG1175	transmembrane transport
C2I06_02120	COG0395	ABC-type sugar transport system, permease component
C2I06_02130	COG3254	rhamnose metabolic process
C2I06_02135	COG5578	integral membrane protein
C2I06_02145	COG2972	Histidine kinase
C2I06_02150	COG2207	Transcriptional regulator
C2I06_02150	COG4753	response regulator
C2I06_02180	COG1266	CAAX protease self-immunity
C2I06_02185	COG1404	Belongs to the peptidase S8 family
C2I06_02190	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2I06_02205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2I06_02210	COG2169	Transcriptional regulator
C2I06_02220	COG0673	inositol 2-dehydrogenase activity
C2I06_02225	COG1082	Xylose isomerase domain protein TIM barrel
C2I06_02230	COG0673	inositol 2-dehydrogenase activity
C2I06_02235	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2I06_02250	COG1595	DNA-templated transcription, initiation
C2I06_02260	COG0772	Belongs to the SEDS family
C2I06_02270	COG0583	DNA-binding transcription factor activity
C2I06_02275	COG1063	alcohol dehydrogenase
C2I06_02280	COG2814	Major facilitator Superfamily
C2I06_02295	COG2205	protein histidine kinase activity
C2I06_02305	COG1252	NADH dehydrogenase
C2I06_02315	COG0778	Nitroreductase
C2I06_02325	COG4193	domain, Protein
C2I06_02330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2I06_02335	COG0791	NLP P60 protein
C2I06_02335	COG3883	PFAM NLP P60 protein
C2I06_02340	COG1121	(ABC) transporter
C2I06_02345	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2I06_02365	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C2I06_02380	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C2I06_02385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I06_02390	COG1119	ATPase activity
C2I06_02395	COG0561	phosphatase activity
C2I06_02405	COG1585	Membrane protein implicated in regulation of membrane protease activity
C2I06_02410	COG2268	Band 7 protein
C2I06_02415	COG2113	Glycine betaine
C2I06_02420	COG4176	ABC-type proline glycine betaine transport system permease component
C2I06_02425	COG4175	Glycine betaine
C2I06_02425	COG0517	IMP dehydrogenase activity
C2I06_02430	COG1510	regulation of RNA biosynthetic process
C2I06_02445	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2I06_02450	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C2I06_02455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2I06_02460	COG4597	amino acid ABC transporter
C2I06_02465	COG0765	amino acid transport
C2I06_02470	COG1126	abc transporter atp-binding protein
C2I06_02480	COG0861	Integral membrane protein TerC family
C2I06_02490	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2I06_02495	COG3594	Acyltransferase
C2I06_02500	COG5002	protein histidine kinase activity
C2I06_02510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2I06_02515	COG0436	Aminotransferase
C2I06_02525	COG3852	Histidine kinase
C2I06_02530	COG1846	Transcriptional regulator
C2I06_02540	COG0542	response to heat
C2I06_02545	COG3949	Membrane
C2I06_02560	COG4873	Protein conserved in bacteria
C2I06_02580	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2I06_02585	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C2I06_02590	COG2084	Dehydrogenase
C2I06_02595	COG0436	Aminotransferase
C2I06_02615	COG0835	chemotaxis
C2I06_02615	COG0784	Response regulator, receiver
C2I06_02630	COG5001	Diguanylate cyclase
C2I06_02630	COG3300	MHYT domain
C2I06_02635	COG4990	cell redox homeostasis
C2I06_02640	COG2200	EAL domain
C2I06_02655	COG4703	Protein of unknown function (DUF1797)
C2I06_02660	COG0517	IMP dehydrogenase activity
C2I06_02665	COG0583	DNA-binding transcription factor activity
C2I06_02670	COG2171	N-acyltransferase activity
C2I06_02675	COG1473	amidohydrolase
C2I06_02680	COG0668	transmembrane transport
C2I06_02685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2I06_02690	COG0569	domain protein
C2I06_02695	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C2I06_02720	COG0022	dehydrogenase e1 component
C2I06_02725	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2I06_02745	COG1982	Orn Lys Arg decarboxylase major
C2I06_02755	COG4493	Belongs to the UPF0637 family
C2I06_02765	COG0483	inositol monophosphate 1-phosphatase activity
C2I06_02785	COG4896	Protein conserved in bacteria
C2I06_02795	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C2I06_02800	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2I06_02810	COG0772	Belongs to the SEDS family
C2I06_02825	COG2340	Cysteine-rich secretory protein family
C2I06_02845	COG3679	Belongs to the UPF0342 family
C2I06_02850	COG4471	UPF0298 protein
C2I06_02855	COG0742	ribosomal rna small subunit methyltransferase
C2I06_02860	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C2I06_02865	COG3314	Sporulation integral membrane protein YlbJ
C2I06_02870	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2I06_02875	COG1323	Belongs to the UPF0348 family
C2I06_02880	COG1399	metal-binding, possibly nucleic acid-binding protein
C2I06_02890	COG1683	Conserved Protein
C2I06_02910	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
C2I06_02915	COG2001	Belongs to the MraZ family
C2I06_02940	COG0768	penicillin binding
C2I06_02945	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2I06_02955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2I06_02960	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C2I06_02970	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2I06_02975	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C2I06_02980	COG3879	Bacterial protein of unknown function (DUF881)
C2I06_02985	COG3879	Bacterial protein of unknown function (DUF881)
C2I06_02990	COG3856	small basic protein
C2I06_02995	COG0849	cell division
C2I06_03000	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C2I06_03010	COG1191	sigma factor activity
C2I06_03015	COG1191	sigma factor activity
C2I06_03025	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2I06_03030	COG1799	cell septum assembly
C2I06_03035	COG0762	integral membrane protein
C2I06_03040	COG2302	S4 RNA-binding domain
C2I06_03045	COG3599	regulation of cell shape
C2I06_03050	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C2I06_03055	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2I06_03060	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C2I06_03065	COG0564	pseudouridine synthase activity
C2I06_03070	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C2I06_03080	COG0540	Belongs to the ATCase OTCase family
C2I06_03085	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2I06_03095	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C2I06_03105	COG0167	dihydroorotate dehydrogenase activity
C2I06_03125	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C2I06_03130	COG1561	YicC-like family, N-terminal region
C2I06_03135	COG2052	Domain of unknown function (DUF370)
C2I06_03140	COG0194	GDP metabolic process
C2I06_03150	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2I06_03155	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2I06_03175	COG3833	ABC-type maltose transport systems, permease component
C2I06_03190	COG3250	beta-galactosidase activity
C2I06_03200	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C2I06_03205	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2I06_03205	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2I06_03215	COG0631	protein serine/threonine phosphatase activity
C2I06_03220	COG0515	serine threonine protein kinase
C2I06_03220	COG2815	serine threonine protein kinase
C2I06_03225	COG1162	GTPase activity
C2I06_03230	COG1564	THIamine pyrophosphokinase
C2I06_03240	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C2I06_03245	COG1302	Protein conserved in bacteria
C2I06_03250	COG1461	Dihydroxyacetone kinase
C2I06_03255	COG1760	l-serine dehydratase
C2I06_03260	COG1760	l-serine dehydratase
C2I06_03265	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2I06_03270	COG1349	DNA-binding transcription factor activity
C2I06_03275	COG0416	fatty acid biosynthetic process
C2I06_03280	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2I06_03285	COG1028	Short-chain dehydrogenase reductase Sdr
C2I06_03290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2I06_03295	COG0571	ribonuclease III activity
C2I06_03300	COG1196	nuclear chromosome segregation
C2I06_03305	COG0552	protein localization to endoplasmic reticulum
C2I06_03320	COG1131	(ABC) transporter
C2I06_03335	COG0714	Associated with various cellular activities
C2I06_03360	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2I06_03370	COG1837	Belongs to the UPF0109 family
C2I06_03380	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C2I06_03395	COG0681	Belongs to the peptidase S26 family
C2I06_03400	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C2I06_03415	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2I06_03420	COG0045	succinate-CoA ligase (ADP-forming) activity
C2I06_03425	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2I06_03430	COG0758	DNA mediated transformation
C2I06_03435	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2I06_03440	COG4974	Belongs to the 'phage' integrase family
C2I06_03450	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C2I06_03455	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C2I06_03460	COG1815	bacterial-type flagellum-dependent cell motility
C2I06_03465	COG1558	bacterial-type flagellum-dependent cell motility
C2I06_03470	COG1677	Flagellar hook-basal body complex protein FliE
C2I06_03475	COG1766	The M ring may be actively involved in energy transduction
C2I06_03480	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2I06_03485	COG1317	bacterial-type flagellum organization
C2I06_03490	COG1157	protein secretion by the type III secretion system
C2I06_03495	COG2882	bacterial-type flagellum organization
C2I06_03510	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C2I06_03520	COG4786	Flagellar basal body rod
C2I06_03525	COG1582	Flagellar protein (FlbD)
C2I06_03530	COG1580	Controls the rotational direction of flagella during chemotaxis
C2I06_03535	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2I06_03540	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2I06_03540	COG1776	CheC inhibitor of MCP methylation
C2I06_03545	COG2201	protein-glutamate methylesterase activity
C2I06_03550	COG3190	flagellar
C2I06_03560	COG1987	bacterial-type flagellum assembly
C2I06_03570	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2I06_03575	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2I06_03585	COG0455	bacterial-type flagellum organization
C2I06_03590	COG2201	protein-glutamate methylesterase activity
C2I06_03595	COG2198	Histidine kinase
C2I06_03595	COG0643	Histidine kinase
C2I06_03600	COG0835	chemotaxis
C2I06_03605	COG1776	CheC inhibitor of MCP methylation
C2I06_03610	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C2I06_03615	COG1191	sigma factor activity
C2I06_03640	COG0528	UMP kinase activity
C2I06_03645	COG0233	cytoplasmic translational termination
C2I06_03650	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C2I06_03655	COG4589	Belongs to the CDS family
C2I06_03665	COG0750	zinc metalloprotease
C2I06_03670	COG0442	prolyl-tRNA aminoacylation
C2I06_03675	COG2176	DNA-directed DNA polymerase activity
C2I06_03680	COG0779	Required for maturation of 30S ribosomal subunits
C2I06_03685	COG0195	Participates in both transcription termination and antitermination
C2I06_03690	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C2I06_03695	COG1358	cellular component organization or biogenesis
C2I06_03705	COG1550	Protein conserved in bacteria
C2I06_03715	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C2I06_03720	COG0196	riboflavin kinase activity
C2I06_03725	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C2I06_03730	COG1185	polyribonucleotide nucleotidyltransferase activity
C2I06_03735	COG0726	polysaccharide deacetylase
C2I06_03740	COG0612	Peptidase, M16
C2I06_03745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2I06_03750	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2I06_03755	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2I06_03760	COG0527	aspartate kinase activity
C2I06_03765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2I06_03770	COG1113	amino acid transport
C2I06_03775	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C2I06_03780	COG0740	serine-type endopeptidase activity
C2I06_03795	COG1674	ftsk spoiiie
C2I06_03795	COG4980	gas vesicle protein
C2I06_03800	COG2188	Transcriptional regulator
C2I06_03835	COG0612	Peptidase, M16
C2I06_03840	COG0612	Peptidase, M16
C2I06_03845	COG0300	oxidoreductase activity
C2I06_03860	COG1426	Protein conserved in bacteria
C2I06_03865	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2I06_03870	COG1546	Belongs to the CinA family
C2I06_03870	COG1058	Belongs to the CinA family
C2I06_03875	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C2I06_03880	COG1418	mRNA catabolic process
C2I06_03885	COG1692	metallophosphoesterase
C2I06_03890	COG2359	stage V sporulation protein S
C2I06_03900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2I06_03905	COG4550	Control of competence regulator ComK, YlbF/YmcA
C2I06_03935	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C2I06_03940	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C2I06_03955	COG3711	transcriptional antiterminator
C2I06_03955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I06_03960	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2I06_03995	COG2217	Heavy metal translocating P-type atpase
C2I06_04000	COG0586	Pfam SNARE associated Golgi protein
C2I06_04015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2I06_04030	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C2I06_04035	COG2271	Major facilitator Superfamily
C2I06_04040	COG1846	Transcriptional regulator
C2I06_04040	COG0456	acetyltransferase
C2I06_04045	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2I06_04050	COG0583	DNA-binding transcription factor activity
C2I06_04055	COG2207	Transcriptional regulator
C2I06_04055	COG0662	Cupin 2, conserved barrel domain protein
C2I06_04070	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2I06_04075	COG1609	Transcriptional regulator
C2I06_04095	COG2318	DinB family
C2I06_04100	COG2207	Transcriptional regulator
C2I06_04115	COG1309	transcriptional regulator
C2I06_04120	COG3773	Cell wall hydrolase
C2I06_04165	COG0531	amino acid
C2I06_04180	COG0640	Transcriptional regulator
C2I06_04205	COG3848	Pyruvate phosphate dikinase
C2I06_04205	COG0574	Belongs to the PEP-utilizing enzyme family
C2I06_04210	COG1794	racemase activity, acting on amino acids and derivatives
C2I06_04215	COG0076	glutamate decarboxylase activity
C2I06_04235	COG0768	penicillin binding
C2I06_04265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2I06_04265	COG0723	plastoquinol--plastocyanin reductase activity
C2I06_04305	COG3715	PTS system
C2I06_04310	COG3716	PTS system mannose fructose sorbose family IID component
C2I06_04315	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I06_04315	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I06_04320	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C2I06_04350	COG1943	Transposase
C2I06_04355	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C2I06_04365	COG1028	Short-chain dehydrogenase reductase Sdr
C2I06_04375	COG2207	Transcriptional regulator
C2I06_04375	COG3708	Transcriptional regulator
C2I06_04380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I06_04405	COG3546	catalase activity
C2I06_04430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I06_04460	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2I06_04465	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2I06_04470	COG0217	transcriptional regulatory protein
C2I06_04485	COG0789	Transcriptional regulator
C2I06_04510	COG0697	spore germination
C2I06_04525	COG0531	amino acid
C2I06_04545	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C2I06_04555	COG0454	-acetyltransferase
C2I06_04570	COG2318	DinB family
C2I06_04610	COG2267	carboxylic ester hydrolase activity
C2I06_04615	COG0596	Alpha beta hydrolase
C2I06_04630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I06_04660	COG0640	Transcriptional regulator
C2I06_04665	COG2814	Major facilitator Superfamily
C2I06_04675	COG1028	Short-chain dehydrogenase reductase Sdr
C2I06_04680	COG1309	transcriptional regulator
C2I06_04685	COG2814	Major facilitator Superfamily
C2I06_04705	COG5002	protein histidine kinase activity
C2I06_04720	COG1011	Hydrolase
C2I06_04785	COG2207	Transcriptional regulator
C2I06_04785	COG3708	Transcriptional regulator
C2I06_04795	COG0018	arginyl-trna synthetase
C2I06_04800	COG4549	nuclear export factor GLE1
C2I06_04825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I06_04835	COG0592	DNA-directed DNA polymerase activity
C2I06_04840	COG2329	Antibiotic biosynthesis monooxygenase
C2I06_04885	COG4106	trans-aconitate 2-methyltransferase activity
C2I06_04895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I06_04920	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2I06_04925	COG0022	dehydrogenase e1 component
C2I06_04930	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2I06_04935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2I06_04940	COG0316	Belongs to the HesB IscA family
C2I06_04975	COG3655	Transcriptional regulator
C2I06_04980	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C2I06_04995	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2I06_05005	COG0288	reversible hydration of carbon dioxide
C2I06_05010	COG5609	conserved protein (DUF2294)
C2I06_05060	COG2076	Multidrug Resistance protein
C2I06_05065	COG2076	Multidrug Resistance protein
C2I06_05070	COG1309	transcriptional regulator
C2I06_05090	COG0412	Dienelactone hydrolase
C2I06_05105	COG0583	DNA-binding transcription factor activity
C2I06_05110	COG1028	Short-chain dehydrogenase reductase Sdr
C2I06_05160	COG5002	protein histidine kinase activity
C2I06_05170	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2I06_05235	COG2244	polysaccharide biosynthetic process
C2I06_05275	COG1104	cysteine desulfurase activity
C2I06_05280	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2I06_05285	COG0157	Belongs to the NadC ModD family
C2I06_05290	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C2I06_05300	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C2I06_05310	COG0464	growth
C2I06_05315	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2I06_05325	COG0789	Transcriptional regulator
C2I06_05330	COG0174	glutamine synthetase
C2I06_05370	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
C2I06_05410	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2I06_05420	COG2080	2 iron, 2 sulfur cluster binding
C2I06_05435	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2I06_05440	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2I06_05450	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2I06_05455	COG4224	UPF0291 protein
C2I06_05475	COG1132	(ABC) transporter
C2I06_05480	COG1132	(ABC) transporter
C2I06_05490	COG0785	Cytochrome C biogenesis protein
C2I06_05495	COG2201	protein-glutamate methylesterase activity
C2I06_05500	COG4846	Membrane protein involved in cytochrome C biogenesis
C2I06_05530	COG1278	Cold shock
C2I06_05535	COG0420	3'-5' exonuclease activity
C2I06_05540	COG0419	ATPase involved in DNA repair
C2I06_05545	COG1876	peptidase activity
C2I06_05550	COG1363	Peptidase, m42
C2I06_05555	COG1368	sulfuric ester hydrolase activity
C2I06_05560	COG3973	AAA domain
C2I06_05565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2I06_05575	COG3764	Sortase (surface protein transpeptidase)
C2I06_05590	COG0456	acetyltransferase
C2I06_05595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I06_05610	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2I06_05620	COG5577	PFAM Coat F domain
C2I06_05625	COG1063	alcohol dehydrogenase
C2I06_05635	COG5577	PFAM Coat F domain
C2I06_05655	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C2I06_05660	COG1247	-acetyltransferase
C2I06_05675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I06_05685	COG1227	inorganic diphosphatase activity
C2I06_05690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2I06_05705	COG0464	growth
C2I06_05725	COG4841	protein insertion into membrane
C2I06_05730	COG2843	Capsule synthesis protein
C2I06_05735	COG3852	Histidine kinase
C2I06_05740	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C2I06_05755	COG1960	acyl-CoA dehydrogenase activity
C2I06_05760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2I06_05760	COG3153	acetyltransferase
C2I06_05765	COG0456	acetyltransferase
C2I06_05770	COG5504	Zn-dependent protease
C2I06_05775	COG1846	Transcriptional regulator
C2I06_05780	COG0477	Major facilitator Superfamily
C2I06_05800	COG1410	methionine synthase
C2I06_05800	COG0646	methionine synthase
C2I06_05805	COG0646	methionine synthase
C2I06_05805	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C2I06_05810	COG0626	cystathionine gamma-synthase activity
C2I06_05815	COG0626	cystathionine gamma-synthase activity
C2I06_05825	COG0745	RESPONSE REGULATOR receiver
C2I06_05830	COG5002	protein histidine kinase activity
C2I06_05835	COG0567	Dehydrogenase, E1 component
C2I06_05840	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2I06_05855	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C2I06_05865	COG0706	membrane insertase activity
C2I06_05875	COG1335	isochorismatase
C2I06_05880	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C2I06_05890	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2I06_05905	COG1686	Belongs to the peptidase S11 family
C2I06_05910	COG0488	(ABC) transporter
C2I06_05915	COG2116	formate transmembrane transporter activity
C2I06_05945	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2I06_05955	COG5002	protein histidine kinase activity
C2I06_05960	COG1388	LysM domain
C2I06_05960	COG3584	3D domain protein
C2I06_05975	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C2I06_05980	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C2I06_05990	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C2I06_05995	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2I06_06000	COG2080	2 iron, 2 sulfur cluster binding
C2I06_06005	COG3648	Uricase
C2I06_06005	COG3195	allantoin biosynthetic process
C2I06_06010	COG2351	hydroxyisourate hydrolase activity
C2I06_06015	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2I06_06040	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2I06_06050	COG0561	phosphatase activity
C2I06_06060	COG1164	Oligoendopeptidase f
C2I06_06065	COG0583	DNA-binding transcription factor activity
C2I06_06070	COG0067	glutamate synthase
C2I06_06070	COG0070	glutamate synthase
C2I06_06070	COG0069	glutamate synthase activity
C2I06_06075	COG0493	'glutamate synthase
C2I06_06080	COG1418	mRNA catabolic process
C2I06_06090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2I06_06095	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2I06_06100	COG1028	Short-chain dehydrogenase reductase Sdr
C2I06_06105	COG0861	Integral membrane protein TerC family
C2I06_06110	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
C2I06_06125	COG0681	Belongs to the peptidase S26 family
C2I06_06135	COG1725	Transcriptional regulator
C2I06_06150	COG4974	Belongs to the 'phage' integrase family
C2I06_06165	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C2I06_06170	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2I06_06170	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2I06_06175	COG0307	riboflavin synthase, alpha
C2I06_06180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I06_06185	COG0708	Exodeoxyribonuclease III
C2I06_06190	COG0346	lactoylglutathione lyase activity
C2I06_06195	COG0561	phosphatase activity
C2I06_06215	COG1366	Belongs to the anti-sigma-factor antagonist family
C2I06_06240	COG1733	regulation of RNA biosynthetic process
C2I06_06245	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2I06_06255	COG2027	D-alanyl-D-alanine carboxypeptidase
C2I06_06265	COG3341	Caulimovirus viroplasmin
C2I06_06265	COG0328	RNA-DNA hybrid ribonuclease activity
C2I06_06270	COG3275	phosphorelay sensor kinase activity
C2I06_06275	COG3279	Response regulator of the LytR AlgR family
C2I06_06280	COG1966	Carbon starvation protein
C2I06_06290	COG2066	Belongs to the glutaminase family
C2I06_06295	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C2I06_06305	COG0840	transmembrane signaling receptor activity
C2I06_06315	COG1280	lysine exporter protein (LysE YggA)
C2I06_06320	COG0024	Methionine aminopeptidase
C2I06_06330	COG0531	amino acid
C2I06_06350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I06_06350	COG0045	succinate-CoA ligase (ADP-forming) activity
C2I06_06350	COG1042	CoA-binding domain protein
C2I06_06355	COG0753	catalase activity
C2I06_06360	COG0326	Molecular chaperone. Has ATPase activity
C2I06_06365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I06_06370	COG1280	lysine exporter protein (LysE YggA)
C2I06_06415	COG3689	TIGRFAM TIGR03943 family protein
C2I06_06420	COG0701	Predicted permease
C2I06_06435	COG0492	ferredoxin-NADP+ reductase activity
C2I06_06440	COG1609	Transcriptional regulator
C2I06_06445	COG1621	beta-fructofuranosidase activity
C2I06_06460	COG0583	DNA-binding transcription factor activity
C2I06_06465	COG0730	response to heat
C2I06_06470	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2I06_06475	COG1349	DNA-binding transcription factor activity
C2I06_06480	COG4977	sequence-specific DNA binding
C2I06_06495	COG1051	belongs to the nudix hydrolase family
C2I06_06500	COG4473	ABC transporter
C2I06_06505	COG1131	(ABC) transporter
C2I06_06510	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2I06_06555	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C2I06_06560	COG0187	DNA topoisomerase II activity
C2I06_06565	COG1832	CoA-binding protein
C2I06_06570	COG0840	transmembrane signaling receptor activity
C2I06_06590	COG3859	Proton-coupled thiamine transporter YuaJ
C2I06_06600	COG1309	transcriptional regulator
C2I06_06615	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2I06_06620	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2I06_06625	COG0204	Acyl-transferase
C2I06_06630	COG0561	phosphatase activity
C2I06_06635	COG1349	DNA-binding transcription factor activity
C2I06_06650	COG1482	cell wall glycoprotein biosynthetic process
C2I06_06655	COG1404	Belongs to the peptidase S8 family
C2I06_06660	COG1943	Transposase
C2I06_06665	COG2814	Major facilitator Superfamily
C2I06_06690	COG1268	BioY protein
C2I06_06695	COG2372	response to copper ion
C2I06_06695	COG1276	copper resistance
C2I06_06710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2I06_06715	COG0737	Belongs to the 5'-nucleotidase family
C2I06_06725	COG0561	phosphatase activity
C2I06_06735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2I06_06740	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C2I06_06755	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I06_06770	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C2I06_06800	COG1695	Transcriptional regulator
C2I06_06810	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C2I06_06815	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C2I06_06820	COG0561	phosphatase activity
C2I06_06825	COG0697	spore germination
C2I06_06830	COG1132	(ABC) transporter
C2I06_06835	COG0583	DNA-binding transcription factor activity
C2I06_06865	COG0512	Glutamine amidotransferase of anthranilate synthase
C2I06_06865	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2I06_06870	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2I06_06880	COG2814	Major facilitator Superfamily
C2I06_06885	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2I06_06885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I06_06885	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2I06_06890	COG1105	Belongs to the carbohydrate kinase PfkB family
C2I06_06895	COG1349	DNA-binding transcription factor activity
C2I06_06910	COG2176	DNA-directed DNA polymerase activity
C2I06_06920	COG0004	ammonium transporteR
C2I06_06935	COG0351	phosphomethylpyrimidine kinase
C2I06_06950	COG0701	Predicted permease
C2I06_06955	COG0523	cobalamin synthesis protein
C2I06_06960	COG0840	transmembrane signaling receptor activity
C2I06_06970	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2I06_07005	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C2I06_07010	COG1737	Transcriptional regulator
C2I06_07025	COG1609	Transcriptional regulator
C2I06_07035	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C2I06_07040	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C2I06_07045	COG0523	cobalamin synthesis protein
C2I06_07090	COG2849	repeat protein
C2I06_07160	COG3739	integral membrane protein
C2I06_07165	COG3655	Transcriptional regulator
C2I06_07180	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
C2I06_07185	COG5646	InterPro IPR014922
C2I06_07215	COG1595	DNA-templated transcription, initiation
C2I06_07230	COG1357	PFAM Pentapeptide repeats (8 copies)
C2I06_07260	COG2733	membrane
C2I06_07290	COG3708	Transcriptional regulator
C2I06_07290	COG2207	Transcriptional regulator
C2I06_07295	COG1115	amino acid carrier protein
C2I06_07325	COG1690	Belongs to the RtcB family
C2I06_07330	COG4377	Putative membrane peptidase family (DUF2324)
C2I06_07345	COG0586	Pfam SNARE associated Golgi protein
C2I06_07365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I06_07375	COG0406	alpha-ribazole phosphatase activity
C2I06_07380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I06_07425	COG0726	polysaccharide deacetylase
C2I06_07445	COG0583	DNA-binding transcription factor activity
C2I06_07455	COG1346	cytolysis
C2I06_07475	COG1278	Cold shock
C2I06_07480	COG0513	Belongs to the DEAD box helicase family
C2I06_07485	COG1278	Cold shock
C2I06_07490	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C2I06_07495	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2I06_07505	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2I06_07510	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
C2I06_07515	COG0671	phosphoesterase, PA-phosphatase related
C2I06_07520	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C2I06_07525	COG1793	dna ligase
C2I06_07525	COG3285	dna ligase
C2I06_07535	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C2I06_07540	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C2I06_07570	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2I06_07575	COG0640	Transcriptional regulator
C2I06_07580	COG0534	Mate efflux family protein
C2I06_07605	COG2340	Cysteine-rich secretory protein family
C2I06_07620	COG0523	cobalamin synthesis protein
C2I06_07625	COG0793	Belongs to the peptidase S41A family
C2I06_07625	COG3409	Peptidoglycan-binding domain 1 protein
C2I06_07630	COG1876	peptidase activity
C2I06_07650	COG4479	Belongs to the UPF0346 family
C2I06_07660	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2I06_07685	COG2755	lipolytic protein G-D-S-L family
C2I06_07690	COG5002	protein histidine kinase activity
C2I06_07695	COG1307	EDD domain protein, DegV family
C2I06_07700	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2I06_07705	COG1272	protein, Hemolysin III
C2I06_07710	COG3716	PTS system mannose fructose sorbose family IID component
C2I06_07715	COG3715	PTS system
C2I06_07720	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I06_07740	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C2I06_07755	COG2310	stress, protein
C2I06_07760	COG2310	stress, protein
C2I06_07765	COG3853	Toxic anion resistance protein (TelA)
C2I06_07785	COG1358	cellular component organization or biogenesis
C2I06_07800	COG0861	Integral membrane protein TerC family
C2I06_07805	COG2310	stress, protein
C2I06_07815	COG2136	Putative SAM-dependent methyltransferase
C2I06_07815	COG2521	methyltransferase
C2I06_07825	COG1413	lyase activity
C2I06_07830	COG0488	(ABC) transporter
C2I06_07835	COG1418	mRNA catabolic process
C2I06_07855	COG0386	Belongs to the glutathione peroxidase family
C2I06_07865	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C2I06_07870	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C2I06_07885	COG1321	iron dependent repressor
C2I06_07915	COG4129	membrane
C2I06_07930	COG1278	Cold shock
C2I06_07940	COG0328	RNA-DNA hybrid ribonuclease activity
C2I06_07945	COG0328	RNA-DNA hybrid ribonuclease activity
C2I06_07955	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
C2I06_07965	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2I06_07975	COG1131	(ABC) transporter
C2I06_07990	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C2I06_08000	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C2I06_08005	COG1199	ATP-dependent helicase activity
C2I06_08010	COG0116	Belongs to the methyltransferase superfamily
C2I06_08025	COG4474	Belongs to the UPF0398 family
C2I06_08035	COG3359	exonuclease
C2I06_08040	COG1111	helicase
C2I06_08040	COG1205	dead DEAH box helicase
C2I06_08045	COG2267	carboxylic ester hydrolase activity
C2I06_08050	COG0071	Belongs to the small heat shock protein (HSP20) family
C2I06_08080	COG3331	DNA recombination
C2I06_08085	COG4499	WXG100 protein secretion system (Wss), protein YukC
C2I06_08085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2I06_08095	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2I06_08100	COG3935	DnaD domain protein
C2I06_08105	COG0017	Asparaginyl-tRNA synthetase
C2I06_08110	COG0436	Aminotransferase
C2I06_08120	COG1199	ATP-dependent helicase activity
C2I06_08120	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2I06_08125	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C2I06_08130	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C2I06_08145	COG0617	tRNA 3'-terminal CCA addition
C2I06_08150	COG0438	transferase activity, transferring glycosyl groups
C2I06_08155	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2I06_08160	COG1803	Methylglyoxal synthase
C2I06_08165	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C2I06_08170	COG1694	Mazg nucleotide pyrophosphohydrolase
C2I06_08175	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I06_08185	COG2223	nitrite transmembrane transporter activity
C2I06_08190	COG2738	Putative neutral zinc metallopeptidase
C2I06_08200	COG4347	Protein of unknown function (DUF1405)
C2I06_08205	COG5582	Belongs to the UPF0302 family
C2I06_08210	COG0457	Tetratricopeptide repeat
C2I06_08220	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C2I06_08225	COG0287	Prephenate dehydrogenase
C2I06_08230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C2I06_08235	COG4401	Chorismate mutase type I
C2I06_08250	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C2I06_08260	COG0142	geranyltranstransferase activity
C2I06_08265	COG2226	methyltransferase
C2I06_08270	COG0142	geranyltranstransferase activity
C2I06_08275	COG0776	regulation of translation
C2I06_08280	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C2I06_08285	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C2I06_08290	COG1160	GTP binding
C2I06_08315	COG0539	negative regulation of cytoplasmic translation
C2I06_08330	COG2959	enzyme of heme biosynthesis
C2I06_08335	COG3409	Peptidoglycan-binding domain 1 protein
C2I06_08335	COG3773	Cell wall hydrolase
C2I06_08340	COG2339	peptidase activity
C2I06_08345	COG0492	ferredoxin-NADP+ reductase activity
C2I06_08350	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2I06_08355	COG4862	establishment of competence for transformation
C2I06_08360	COG1408	metallophosphoesterase
C2I06_08375	COG3546	catalase activity
C2I06_08390	COG1266	CAAX protease self-immunity
C2I06_08395	COG0514	ATP-dependent DNA helicase (RecQ)
C2I06_08405	COG1141	Ferredoxin
C2I06_08410	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C2I06_08415	COG0739	heme binding
C2I06_08430	COG1595	DNA-templated transcription, initiation
C2I06_08435	COG5002	protein histidine kinase activity
C2I06_08440	COG0745	RESPONSE REGULATOR receiver
C2I06_08450	COG0700	Nucleoside recognition
C2I06_08455	COG2715	membrane protein required for spore maturation
C2I06_08460	COG1686	Belongs to the peptidase S11 family
C2I06_08465	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2I06_08470	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C2I06_08475	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C2I06_08480	COG1547	Domain of unknown function (DUF309)
C2I06_08490	COG4086	secreted protein
C2I06_08500	COG0697	spore germination
C2I06_08525	COG2172	sigma factor antagonist activity
C2I06_08535	COG1686	Belongs to the peptidase S11 family
C2I06_08540	COG0024	Methionine aminopeptidase
C2I06_08545	COG1595	DNA-templated transcription, initiation
C2I06_08565	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C2I06_08595	COG4974	Belongs to the 'phage' integrase family
C2I06_08605	COG0735	belongs to the Fur family
C2I06_08610	COG1300	Membrane
C2I06_08620	COG1379	DNA repair
C2I06_08635	COG0667	Aldo Keto reductase
C2I06_08655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I06_08660	COG0456	acetyltransferase
C2I06_08665	COG0346	lactoylglutathione lyase activity
C2I06_08670	COG1078	dGTPase activity
C2I06_08715	COG1028	Short-chain dehydrogenase reductase Sdr
C2I06_08720	COG1063	alcohol dehydrogenase
C2I06_08725	COG4948	Mandelate Racemase Muconate Lactonizing
C2I06_08730	COG2186	Transcriptional regulator
C2I06_08765	COG0494	nUDIX hydrolase
C2I06_08775	COG1595	DNA-templated transcription, initiation
C2I06_08805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2I06_08810	COG3620	sequence-specific DNA binding
C2I06_08840	COG1764	response to oxidative stress
C2I06_08845	COG1073	alpha beta
C2I06_08850	COG2814	Major facilitator Superfamily
C2I06_08855	COG0640	Transcriptional regulator
C2I06_08900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2I06_08905	COG2814	Major facilitator Superfamily
C2I06_08910	COG1846	Transcriptional regulator
C2I06_08920	COG0300	oxidoreductase activity
C2I06_08930	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2I06_08935	COG1234	tRNA 3'-trailer cleavage
C2I06_08940	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C2I06_08945	COG1408	metallophosphoesterase
C2I06_08955	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C2I06_08960	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2I06_08970	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2I06_08975	COG1376	ErfK ybiS ycfS ynhG family protein
C2I06_08980	COG1126	abc transporter atp-binding protein
C2I06_08985	COG0765	amino acid transport
C2I06_08990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2I06_09000	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2I06_09005	COG0022	dehydrogenase e1 component
C2I06_09010	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2I06_09015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2I06_09020	COG3426	butyrate kinase activity
C2I06_09025	COG3829	transcription factor binding
C2I06_09025	COG3290	protein histidine kinase activity
C2I06_09030	COG0584	glycerophosphoryl diester phosphodiesterase
C2I06_09045	COG0745	RESPONSE REGULATOR receiver
C2I06_09050	COG1575	Belongs to the MenA family. Type 1 subfamily
C2I06_09055	COG0750	zinc metalloprotease
C2I06_09060	COG0497	DNA recombination
C2I06_09065	COG1438	arginine binding
C2I06_09070	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C2I06_09075	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C2I06_09080	COG0142	geranyltranstransferase activity
C2I06_09085	COG1722	exodeoxyribonuclease VII activity
C2I06_09100	COG1302	Protein conserved in bacteria
C2I06_09110	COG0511	ligase activity, forming carbon-carbon bonds
C2I06_09150	COG3854	ATPases associated with a variety of cellular activities
C2I06_09160	COG1785	Belongs to the alkaline phosphatase family
C2I06_09170	COG2723	6-phospho-beta-galactosidase activity
C2I06_09175	COG1501	Belongs to the glycosyl hydrolase 31 family
C2I06_09190	COG0395	ABC-type sugar transport system, permease component
C2I06_09195	COG4209	transmembrane transport
C2I06_09210	COG4753	response regulator
C2I06_09210	COG2207	Transcriptional regulator
C2I06_09215	COG2972	Histidine kinase
C2I06_09235	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C2I06_09240	COG0006	proline dipeptidase activity
C2I06_09250	COG3872	metal-dependent enzyme
C2I06_09260	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2I06_09295	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2I06_09300	COG0095	Lipoate-protein ligase
C2I06_09305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2I06_09310	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2I06_09315	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2I06_09320	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C2I06_09325	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2I06_09360	COG4537	Required for transformation and DNA binding
C2I06_09365	COG1459	type II secretion system
C2I06_09370	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2I06_09405	COG1388	LysM domain
C2I06_09405	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2I06_09495	COG0740	serine-type endopeptidase activity
C2I06_09600	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
C2I06_09615	COG1484	DNA-dependent DNA replication
C2I06_09625	COG3723	Recombinational DNA repair protein, rece pathway
C2I06_09630	COG5377	YqaJ viral recombinase family
C2I06_09655	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2I06_09680	COG2072	flavoprotein involved in K transport
C2I06_09690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I06_09695	COG0011	TIGRFAM Protein of
C2I06_09710	COG1368	sulfuric ester hydrolase activity
C2I06_09715	COG1940	carbohydrate kinase activity
C2I06_09730	COG0457	Tetratricopeptide repeat
C2I06_09730	COG0705	Rhomboid family
C2I06_09735	COG2318	DinB family
C2I06_09750	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2I06_09755	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C2I06_09785	COG0704	Plays a role in the regulation of phosphate uptake
C2I06_09790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2I06_09795	COG0581	inorganic phosphate transmembrane transporter activity
C2I06_09800	COG0573	inorganic phosphate transmembrane transporter activity
C2I06_09805	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2I06_09820	COG0477	Major facilitator Superfamily
C2I06_09830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2I06_09835	COG2839	Protein conserved in bacteria
C2I06_09840	COG5521	maltodextrose utilization protein MalA
C2I06_09855	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C2I06_09865	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
C2I06_09870	COG0735	belongs to the Fur family
C2I06_09880	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C2I06_09885	COG0513	Belongs to the DEAD box helicase family
C2I06_09895	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C2I06_09900	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2I06_09905	COG2384	SAM-dependent methyltransferase
C2I06_09915	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2I06_09920	COG0358	DNA primase activity
C2I06_09925	COG1671	Belongs to the UPF0178 family
C2I06_09935	COG0517	IMP dehydrogenase activity
C2I06_09940	COG0751	glycine-tRNA ligase activity
C2I06_09955	COG1381	Involved in DNA repair and RecF pathway recombination
C2I06_09965	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C2I06_09970	COG0295	cytidine deaminase activity
C2I06_09975	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2I06_09985	COG1480	7TM receptor with intracellular HD hydrolase
C2I06_09990	COG1702	phosphate starvation-inducible protein PhoH
C2I06_10010	COG4864	UPF0365 protein
C2I06_10015	COG1030	water channel activity
C2I06_10020	COG1610	YqeY-like protein
C2I06_10025	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C2I06_10030	COG1283	sodium-dependent phosphate transmembrane transporter activity
C2I06_10040	COG1132	(ABC) transporter
C2I06_10045	COG1132	(ABC) transporter
C2I06_10050	COG2207	Transcriptional regulator
C2I06_10050	COG1917	Cupin 2, conserved barrel domain protein
C2I06_10055	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C2I06_10060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2I06_10065	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2I06_10070	COG2264	protein methyltransferase activity
C2I06_10080	COG0443	Heat shock 70 kDa protein
C2I06_10085	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C2I06_10090	COG1420	regulation of RNA biosynthetic process
C2I06_10095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2I06_10100	COG0481	GTPase activity
C2I06_10115	COG0268	Binds directly to 16S ribosomal RNA
C2I06_10120	COG1466	dna polymerase III delta subunit
C2I06_10125	COG0658	competence protein
C2I06_10125	COG2333	competence protein COMEC
C2I06_10130	COG2131	deaminase
C2I06_10135	COG1596	polysaccharide export
C2I06_10135	COG1555	photosystem II stabilization
C2I06_10140	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2I06_10145	COG2226	methyltransferase
C2I06_10150	COG0799	negative regulation of ribosome biogenesis
C2I06_10155	COG1713	HD superfamily hydrolase involved in NAD metabolism
C2I06_10160	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C2I06_10165	COG1534	Rna-binding protein
C2I06_10175	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C2I06_10180	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
C2I06_10190	COG0688	phosphatidylethanolamine metabolic process
C2I06_10195	COG1183	phosphatidylcholine synthase activity
C2I06_10210	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2I06_10230	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2I06_10240	COG1943	Transposase
C2I06_10290	COG5492	domain, Protein
C2I06_10295	COG5492	domain, Protein
C2I06_10300	COG1943	Transposase
C2I06_10325	COG5484	DNA packaging
C2I06_10325	COG3728	DNA packaging
C2I06_10375	COG0572	uridine kinase
C2I06_10380	COG4977	sequence-specific DNA binding
C2I06_10385	COG0673	inositol 2-dehydrogenase activity
C2I06_10395	COG0673	inositol 2-dehydrogenase activity
C2I06_10405	COG0789	Transcriptional regulator
C2I06_10440	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
C2I06_10455	COG0626	cystathionine gamma-synthase activity
C2I06_10460	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2I06_10465	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2I06_10470	COG2226	methyltransferase
C2I06_10485	COG0768	penicillin binding
C2I06_10490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2I06_10495	COG0572	uridine kinase
C2I06_10515	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2I06_10520	COG3906	Belongs to the UPF0473 family
C2I06_10530	COG4472	Bacterial protein of unknown function (DUF965)
C2I06_10540	COG0628	permease
C2I06_10555	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2I06_10570	COG1104	cysteine desulfurase activity
C2I06_10575	COG1959	2 iron, 2 sulfur cluster binding
C2I06_10580	COG2364	Membrane
C2I06_10585	COG1473	amidohydrolase
C2I06_10595	COG4948	Mandelate Racemase Muconate Lactonizing
C2I06_10630	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2I06_10635	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C2I06_10640	COG1131	(ABC) transporter
C2I06_10645	COG1131	(ABC) transporter
C2I06_10650	COG1725	Transcriptional regulator
C2I06_10660	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2I06_10665	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C2I06_10670	COG0124	histidyl-tRNA synthetase
C2I06_10675	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2I06_10675	COG3103	Sh3 type 3 domain protein
C2I06_10675	COG4991	sh3 domain protein
C2I06_10685	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2I06_10690	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2I06_10695	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2I06_10695	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C2I06_10700	COG5416	Lipopolysaccharide assembly protein A domain
C2I06_10705	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2I06_10705	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2I06_10715	COG2244	polysaccharide biosynthetic process
C2I06_10720	COG2323	membrane
C2I06_10730	COG1862	Preprotein translocase
C2I06_10740	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C2I06_10785	COG1827	regulation of RNA biosynthetic process
C2I06_10790	COG0077	Prephenate dehydratase
C2I06_10795	COG4492	Belongs to the UPF0735 family
C2I06_10800	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C2I06_10805	COG3290	protein histidine kinase activity
C2I06_10810	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C2I06_10815	COG2868	ribosomal protein
C2I06_10820	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C2I06_10825	COG1530	ribonuclease E activity
C2I06_10830	COG1994	Peptidase M50
C2I06_10835	COG0739	heme binding
C2I06_10840	COG2894	cell division
C2I06_10845	COG0850	regulation of cytokinetic process
C2I06_10850	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C2I06_10855	COG1792	Involved in formation and maintenance of cell shape
C2I06_10860	COG1077	Cell shape determining protein MreB Mrl
C2I06_10865	COG2003	Belongs to the UPF0758 family
C2I06_10870	COG0424	maF-like protein
C2I06_10900	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C2I06_10920	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2I06_10960	COG3706	GGDEF domain
C2I06_10965	COG0285	dihydrofolate synthase activity
C2I06_10970	COG0525	valine-tRNA ligase activity
C2I06_10980	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2I06_10985	COG1388	LysM domain
C2I06_10985	COG1388	LysM domain
C2I06_10990	COG1649	PFAM Uncharacterised BCR, COG1649
C2I06_10990	COG0726	polysaccharide deacetylase
C2I06_11000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2I06_11010	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2I06_11015	COG0113	porphobilinogen synthase activity
C2I06_11025	COG0181	hydroxymethylbilane synthase activity
C2I06_11030	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2I06_11045	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C2I06_11050	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2I06_11055	COG1067	ATP-dependent peptidase activity
C2I06_11055	COG0470	DNA polymerase III
C2I06_11065	COG0544	peptidyl-prolyl cis-trans isomerase activity
C2I06_11075	COG0066	3-isopropylmalate dehydratase activity
C2I06_11080	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C2I06_11085	COG0473	3-isopropylmalate dehydrogenase activity
C2I06_11090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2I06_11095	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C2I06_11100	COG0440	acetolactate synthase activity
C2I06_11105	COG0028	Belongs to the TPP enzyme family
C2I06_11115	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
C2I06_11130	COG0622	Phosphoesterase
C2I06_11145	COG5401	PFAM Sporulation and spore germination
C2I06_11150	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C2I06_11155	COG1846	Transcriptional regulator
C2I06_11160	COG2197	response regulator
C2I06_11170	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2I06_11175	COG1053	succinate dehydrogenase
C2I06_11180	COG2009	succinate dehydrogenase
C2I06_11185	COG1719	4-vinyl reductase, 4VR
C2I06_11200	COG3118	belongs to the thioredoxin family
C2I06_11205	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C2I06_11210	COG2086	electron transfer activity
C2I06_11215	COG0318	PFAM AMP-dependent synthetase and ligase
C2I06_11220	COG3766	membrane
C2I06_11225	COG1193	negative regulation of DNA recombination
C2I06_11230	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C2I06_11230	COG1796	DNA polymerase
C2I06_11240	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
C2I06_11245	COG1940	carbohydrate kinase activity
C2I06_11255	COG0395	ABC-type sugar transport system, permease component
C2I06_11260	COG1175	transmembrane transport
C2I06_11270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2I06_11270	COG0072	phenylalanine-tRNA ligase activity
C2I06_11275	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C2I06_11280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2I06_11290	COG1070	Carbohydrate kinase
C2I06_11295	COG2115	Belongs to the xylose isomerase family
C2I06_11300	COG1940	carbohydrate kinase activity
C2I06_11305	COG0628	permease
C2I06_11310	COG1363	Peptidase, m42
C2I06_11325	COG3326	Membrane
C2I06_11330	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C2I06_11340	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C2I06_11345	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2I06_11360	COG1484	DNA-dependent DNA replication
C2I06_11365	COG3611	Membrane attachment protein
C2I06_11370	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C2I06_11380	COG1971	Probably functions as a manganese efflux pump
C2I06_11385	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C2I06_11395	COG5002	protein histidine kinase activity
C2I06_11400	COG0745	RESPONSE REGULATOR receiver
C2I06_11410	COG0538	isocitrate dehydrogenase activity
C2I06_11415	COG0372	Belongs to the citrate synthase family
C2I06_11420	COG2707	UPF0756 membrane protein
C2I06_11425	COG0628	permease
C2I06_11460	COG1028	Short-chain dehydrogenase reductase Sdr
C2I06_11475	COG0395	ABC-type sugar transport system, permease component
C2I06_11480	COG4209	transmembrane transport
C2I06_11485	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2I06_11490	COG5578	integral membrane protein
C2I06_11500	COG1175	transmembrane transport
C2I06_11505	COG1653	transport
C2I06_11510	COG2207	Transcriptional regulator
C2I06_11515	COG2972	Histidine kinase
C2I06_11520	COG3030	protein affecting phage T7 exclusion by the F plasmid
C2I06_11535	COG0825	malonyl-CoA metabolic process
C2I06_11540	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C2I06_11545	COG2186	Transcriptional regulator
C2I06_11550	COG0587	DNA-directed DNA polymerase activity
C2I06_11565	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C2I06_11570	COG4109	DRTGG domain
C2I06_11580	COG0006	proline dipeptidase activity
C2I06_11590	COG0589	response to stress
C2I06_11595	COG0165	Argininosuccinate lyase
C2I06_11600	COG0137	argininosuccinate synthase activity
C2I06_11605	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2I06_11610	COG3973	AAA domain
C2I06_11625	COG0827	DNA restriction-modification system
C2I06_11630	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C2I06_11635	COG3874	Sporulation protein YtfJ
C2I06_11645	COG1714	RDD family
C2I06_11650	COG0616	signal peptide processing
C2I06_11655	COG2962	Rard protein
C2I06_11660	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C2I06_11665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2I06_11675	COG0301	tRNA thio-modification
C2I06_11680	COG1104	cysteine desulfurase activity
C2I06_11685	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
C2I06_11690	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C2I06_11695	COG1309	transcriptional regulator
C2I06_11700	COG1956	GAF domain-containing protein
C2I06_11705	COG2203	Gaf domain
C2I06_11705	COG2199	diguanylate cyclase activity
C2I06_11710	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C2I06_11735	COG1605	Chorismate mutase
C2I06_11735	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C2I06_11740	COG0849	cell division
C2I06_11745	COG3118	belongs to the thioredoxin family
C2I06_11750	COG4980	gas vesicle protein
C2I06_11755	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
C2I06_11760	COG2309	aminopeptidase activity
C2I06_11765	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2I06_11770	COG1674	ftsk spoiiie
C2I06_11775	COG4848	Belongs to the UPF0354 family
C2I06_11780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2I06_11785	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
C2I06_11790	COG1363	Peptidase, m42
C2I06_11795	COG5584	Small secreted protein
C2I06_11800	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C2I06_11810	COG0510	thiamine kinase activity
C2I06_11815	COG1523	belongs to the glycosyl hydrolase 13 family
C2I06_11825	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C2I06_11835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2I06_11845	COG1349	DNA-binding transcription factor activity
C2I06_11850	COG1187	pseudouridine synthase activity
C2I06_11855	COG2244	polysaccharide biosynthetic process
C2I06_11860	COG2081	HI0933 family
C2I06_11870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2I06_11875	COG0495	leucyl-tRNA aminoacylation
C2I06_11885	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
C2I06_11890	COG0154	amidase activity
C2I06_11895	COG0406	alpha-ribazole phosphatase activity
C2I06_11900	COG2814	Major facilitator Superfamily
C2I06_11915	COG1242	4 iron, 4 sulfur cluster binding
C2I06_11920	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C2I06_11930	COG2267	carboxylic ester hydrolase activity
C2I06_11935	COG4990	cell redox homeostasis
C2I06_11940	COG0367	asparagine synthase
C2I06_11945	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C2I06_11955	COG1506	peptidase
C2I06_11960	COG0494	nUDIX hydrolase
C2I06_11975	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2I06_11985	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C2I06_11990	COG0288	reversible hydration of carbon dioxide
C2I06_12010	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C2I06_12015	COG0596	Alpha beta hydrolase
C2I06_12025	COG1169	isochorismate synthase
C2I06_12030	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2I06_12035	COG0058	SHG alpha-glucan phosphorylase activity
C2I06_12040	COG0297	glycogen (starch) synthase activity
C2I06_12045	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2I06_12185	COG1285	pathogenesis
C2I06_12205	COG5002	protein histidine kinase activity
C2I06_12225	COG0604	alcohol dehydrogenase
C2I06_12230	COG1028	Short-chain dehydrogenase reductase Sdr
C2I06_12235	COG0778	Nitroreductase
C2I06_12245	COG3729	General stress protein
C2I06_12265	COG2059	Chromate
C2I06_12270	COG2059	Chromate
C2I06_12280	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2I06_12280	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2I06_12290	COG1309	transcriptional regulator
C2I06_12295	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2I06_12305	COG1943	Transposase
C2I06_12315	COG1979	alcohol dehydrogenase
C2I06_12320	COG2155	Conserved Protein
C2I06_12325	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2I06_12330	COG1098	S1 RNA binding domain
C2I06_12335	COG0436	Aminotransferase
C2I06_12340	COG1522	sequence-specific DNA binding
C2I06_12350	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2I06_12355	COG2011	ABC-type metal ion transport system permease component
C2I06_12360	COG1464	Belongs to the NlpA lipoprotein family
C2I06_12370	COG1914	H( )-stimulated, divalent metal cation uptake system
C2I06_12375	COG2032	superoxide dismutase activity
C2I06_12385	COG5018	Exonuclease
C2I06_12395	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2I06_12395	COG2111	Na H antiporter
C2I06_12400	COG2111	Na H antiporter
C2I06_12405	COG1006	Multisubunit Na H antiporter MnhC subunit
C2I06_12410	COG0651	ATP synthesis coupled electron transport
C2I06_12415	COG1863	multisubunit Na H antiporter MnhE subunit
C2I06_12420	COG2212	antiporter activity
C2I06_12425	COG1320	monovalent cation:proton antiporter activity
C2I06_12445	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2I06_12475	COG1028	Short-chain dehydrogenase reductase Sdr
C2I06_12485	COG3243	poly(R)-hydroxyalkanoic acid synthase
C2I06_12490	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2I06_12495	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
C2I06_12500	COG3584	3D domain protein
C2I06_12505	COG0492	ferredoxin-NADP+ reductase activity
C2I06_12535	COG1476	TRANSCRIPTIONal
C2I06_12590	COG0316	Belongs to the HesB IscA family
C2I06_12600	COG4844	belongs to the
C2I06_12605	COG1252	NADH dehydrogenase
C2I06_12610	COG4837	Protein of unknown function (DUF1462)
C2I06_12615	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C2I06_12620	COG0083	homoserine kinase activity
C2I06_12625	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2I06_12630	COG0460	homoserine dehydrogenase
C2I06_12635	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2I06_12640	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2I06_12645	COG0647	UMP catabolic process
C2I06_12650	COG2445	Protein of unknown function DUF86
C2I06_12655	COG2199	diguanylate cyclase activity
C2I06_12655	COG2200	EAL domain
C2I06_12655	COG3287	FIST C domain
C2I06_12660	COG4470	Protein conserved in bacteria
C2I06_12665	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C2I06_12680	COG3377	Domain of unknown function (DUF1805)
C2I06_12685	COG0737	Belongs to the 5'-nucleotidase family
C2I06_12690	COG1801	Protein of unknown function DUF72
C2I06_12695	COG1028	Short-chain dehydrogenase reductase Sdr
C2I06_12700	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
C2I06_12715	COG1414	Transcriptional regulator
C2I06_12720	COG0561	phosphatase activity
C2I06_12725	COG0110	maltose O-acetyltransferase activity
C2I06_12730	COG0346	lactoylglutathione lyase activity
C2I06_12740	COG1940	carbohydrate kinase activity
C2I06_12745	COG0719	Fe-S assembly protein
C2I06_12750	COG0822	iron-sulfur transferase activity
C2I06_12755	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2I06_12760	COG0719	Fe-S assembly protein
C2I06_12765	COG0396	ATPase activity
C2I06_12770	COG1464	Belongs to the NlpA lipoprotein family
C2I06_12775	COG2011	ABC-type metal ion transport system permease component
C2I06_12780	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2I06_12790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2I06_12795	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C2I06_12800	COG0509	glycine decarboxylation via glycine cleavage system
C2I06_12805	COG1393	Belongs to the ArsC family
C2I06_12810	COG1960	acyl-CoA dehydrogenase activity
C2I06_12815	COG1024	Enoyl-CoA hydratase
C2I06_12815	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2I06_12830	COG5577	PFAM Coat F domain
C2I06_12840	COG0772	Belongs to the SEDS family
C2I06_12845	COG0840	transmembrane signaling receptor activity
C2I06_12850	COG1126	abc transporter atp-binding protein
C2I06_12855	COG0765	amino acid transport
C2I06_12860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2I06_12875	COG1132	(ABC) transporter
C2I06_12880	COG1132	(ABC) transporter
C2I06_12885	COG3118	belongs to the thioredoxin family
C2I06_12890	COG0544	peptidyl-prolyl cis-trans isomerase activity
C2I06_12910	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2I06_12930	COG1968	undecaprenyl-diphosphatase activity
C2I06_12935	COG0628	permease
C2I06_12940	COG1033	growth of symbiont in host cell
C2I06_12940	COG2409	Drug exporters of the RND superfamily
C2I06_12945	COG1846	Transcriptional regulator
C2I06_12950	COG2050	protein possibly involved in aromatic compounds catabolism
C2I06_12960	COG0366	Alpha amylase catalytic
C2I06_12965	COG1609	Transcriptional regulator
C2I06_12970	COG1733	regulation of RNA biosynthetic process
C2I06_12975	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
C2I06_12980	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C2I06_12990	COG3764	Sortase (surface protein transpeptidase)
C2I06_12995	COG1283	sodium-dependent phosphate transmembrane transporter activity
C2I06_13005	COG0488	(ABC) transporter
C2I06_13010	COG1609	Transcriptional regulator
C2I06_13015	COG0673	inositol 2-dehydrogenase activity
C2I06_13020	COG1874	Beta-galactosidase
C2I06_13025	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C2I06_13030	COG0395	ABC-type sugar transport system, permease component
C2I06_13035	COG1175	transmembrane transport
C2I06_13040	COG1653	transport
C2I06_13045	COG4753	response regulator
C2I06_13045	COG2207	Transcriptional regulator
C2I06_13050	COG2972	Histidine kinase
C2I06_13055	COG5578	integral membrane protein
C2I06_13065	COG5577	PFAM Coat F domain
C2I06_13070	COG1366	Belongs to the anti-sigma-factor antagonist family
C2I06_13085	COG1012	belongs to the aldehyde dehydrogenase family
C2I06_13090	COG0710	3-dehydroquinate dehydratase activity
C2I06_13095	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2I06_13100	COG0753	catalase activity
C2I06_13110	COG0656	L-ascorbic acid biosynthetic process
C2I06_13115	COG0395	ABC-type sugar transport system, permease component
C2I06_13120	COG1175	transmembrane transport
C2I06_13125	COG1653	transport
C2I06_13130	COG1486	melibiose metabolic process
C2I06_13135	COG2207	Transcriptional regulator
C2I06_13145	COG2217	Heavy metal translocating P-type atpase
C2I06_13150	COG2608	mercury ion transmembrane transporter activity
C2I06_13160	COG1802	Transcriptional regulator
C2I06_13175	COG0789	Transcriptional regulator
C2I06_13180	COG2188	Transcriptional regulator
C2I06_13185	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C2I06_13200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I06_13225	COG0765	amino acid transport
C2I06_13230	COG1126	abc transporter atp-binding protein
C2I06_13245	COG0395	ABC-type sugar transport system, permease component
C2I06_13250	COG1175	transmembrane transport
C2I06_13255	COG1653	transport
C2I06_13265	COG1012	belongs to the aldehyde dehydrogenase family
C2I06_13275	COG1063	alcohol dehydrogenase
C2I06_13280	COG3775	system Galactitol-specific IIC component
C2I06_13295	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I06_13295	COG3711	transcriptional antiterminator
C2I06_13305	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C2I06_13310	COG0557	exoribonuclease II activity
C2I06_13315	COG1647	Serine aminopeptidase, S33
C2I06_13320	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2I06_13335	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C2I06_13375	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I06_13385	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C2I06_13390	COG1660	Displays ATPase and GTPase activities
C2I06_13395	COG1051	belongs to the nudix hydrolase family
C2I06_13410	COG0492	ferredoxin-NADP+ reductase activity
C2I06_13420	COG0457	Tetratricopeptide repeat
C2I06_13425	COG0140	phosphoribosyl-ATP diphosphatase activity
C2I06_13425	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C2I06_13430	COG0107	imidazoleglycerol-phosphate synthase activity
C2I06_13435	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C2I06_13440	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C2I06_13445	COG0131	Imidazoleglycerol-phosphate dehydratase
C2I06_13450	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C2I06_13455	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C2I06_13460	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C2I06_13465	COG0110	maltose O-acetyltransferase activity
C2I06_13470	COG0546	phosphoglycolate phosphatase activity
C2I06_13485	COG1950	PFAM Membrane protein of
C2I06_13490	COG3595	metallopeptidase activity
C2I06_13495	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C2I06_13500	COG0556	nucleotide-excision repair
C2I06_13505	COG4897	Protein conserved in bacteria
C2I06_13510	COG1366	Belongs to the anti-sigma-factor antagonist family
C2I06_13525	COG1012	belongs to the aldehyde dehydrogenase family
C2I06_13525	COG1454	alcohol dehydrogenase
C2I06_13540	COG1595	DNA-templated transcription, initiation
C2I06_13550	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C2I06_13565	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C2I06_13570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2I06_13575	COG2508	Transcriptional regulator
C2I06_13580	COG2233	PERMEase
C2I06_13585	COG0281	malic enzyme
C2I06_13610	COG1053	succinate dehydrogenase
C2I06_13615	COG2030	dehydratase
C2I06_13620	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2I06_13625	COG4988	ABC transporter
C2I06_13630	COG1294	oxidase, subunit
C2I06_13635	COG1271	oxidase subunit
C2I06_13640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2I06_13645	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2I06_13650	COG0205	6-phosphofructokinase activity
C2I06_13655	COG0698	ribose 5-phosphate isomerase
C2I06_13665	COG1063	alcohol dehydrogenase
C2I06_13670	COG3775	system Galactitol-specific IIC component
C2I06_13675	COG3414	Phosphotransferase system galactitol-specific IIB component
C2I06_13680	COG3414	Phosphotransferase system galactitol-specific IIB component
C2I06_13695	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2I06_13700	COG0205	6-phosphofructokinase activity
C2I06_13705	COG0698	ribose 5-phosphate isomerase
C2I06_13715	COG0656	L-ascorbic acid biosynthetic process
C2I06_13720	COG2814	Major facilitator Superfamily
C2I06_13725	COG1733	regulation of RNA biosynthetic process
C2I06_13730	COG3409	Peptidoglycan-binding domain 1 protein
C2I06_13730	COG0793	Belongs to the peptidase S41A family
C2I06_13735	COG3546	catalase activity
C2I06_13740	COG2217	Heavy metal translocating P-type atpase
C2I06_13745	COG0640	Transcriptional regulator
C2I06_13755	COG2177	Part of the ABC transporter FtsEX involved in
C2I06_13760	COG2884	Cell division ATP-binding protein ftsE
C2I06_13765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I06_13785	COG0463	Glycosyl transferase, family 2
C2I06_13795	COG0653	protein targeting
C2I06_13820	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C2I06_13825	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2I06_13830	COG3842	ATPase activity
C2I06_13845	COG1802	Transcriptional regulator
C2I06_13850	COG2059	Chromate
C2I06_13855	COG2059	Chromate
C2I06_13860	COG0405	Gamma-glutamyltransferase
C2I06_13875	COG1522	sequence-specific DNA binding
C2I06_13885	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2I06_13895	COG1516	flagellar protein fliS
C2I06_13900	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C2I06_13910	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2I06_13915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2I06_13920	COG2089	acid synthase
C2I06_13930	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
C2I06_13950	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C2I06_13955	COG1215	transferase activity, transferring glycosyl groups
C2I06_13975	COG1086	Polysaccharide biosynthesis protein
C2I06_13990	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C2I06_13995	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
C2I06_14000	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2I06_14005	COG4786	Flagellar basal body rod
C2I06_14005	COG1256	bacterial-type flagellum assembly
C2I06_14020	COG1728	Protein conserved in bacteria
C2I06_14030	COG1516	flagellar protein fliS
C2I06_14050	COG1040	competence protein
C2I06_14055	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C2I06_14065	COG1307	EDD domain protein, DegV family
C2I06_14070	COG2197	response regulator
C2I06_14075	COG4585	Histidine kinase
C2I06_14080	COG1739	Uncharacterized protein family UPF0029
C2I06_14085	COG1316	TRANSCRIPTIONal
C2I06_14090	COG2247	cell wall binding repeat
C2I06_14090	COG2385	sporulation resulting in formation of a cellular spore
C2I06_14095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2I06_14100	COG1216	Glycosyl transferase, family 2
C2I06_14100	COG1442	glycosyl transferase family 8
C2I06_14105	COG1134	teichoic acid transport
C2I06_14110	COG1682	transport, permease protein
C2I06_14115	COG4193	domain, Protein
C2I06_14120	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2I06_14130	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C2I06_14135	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C2I06_14145	COG0346	lactoylglutathione lyase activity
C2I06_14150	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2I06_14155	COG0366	Alpha amylase catalytic
C2I06_14160	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
C2I06_14170	COG0629	single-stranded DNA binding
C2I06_14175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2I06_14185	COG0840	transmembrane signaling receptor activity
C2I06_14190	COG2814	Major facilitator Superfamily
C2I06_14195	COG1335	isochorismatase
C2I06_14200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2I06_14205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2I06_14220	COG1012	belongs to the aldehyde dehydrogenase family
C2I06_14240	COG0604	alcohol dehydrogenase
C2I06_14245	COG1660	Displays ATPase and GTPase activities
C2I06_14250	COG0371	Dehydrogenase
C2I06_14255	COG2084	Dehydrogenase
C2I06_14260	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
C2I06_14265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2I06_14270	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
C2I06_14285	COG3339	Conserved Protein
C2I06_14290	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2I06_14305	COG2011	ABC-type metal ion transport system permease component
C2I06_14310	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2I06_14320	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2I06_14325	COG0840	transmembrane signaling receptor activity
C2I06_14330	COG0745	RESPONSE REGULATOR receiver
C2I06_14335	COG0642	Histidine kinase
C2I06_14340	COG1136	(ABC) transporter
C2I06_14345	COG0577	efflux transmembrane transporter activity
C2I06_14355	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C2I06_14360	COG4191	Histidine kinase
C2I06_14385	COG1737	Transcriptional regulator
C2I06_14390	COG1486	melibiose metabolic process
C2I06_14395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I06_14395	COG1263	PTS System
C2I06_14400	COG0300	oxidoreductase activity
C2I06_14405	COG0656	L-ascorbic acid biosynthetic process
C2I06_14410	COG1053	succinate dehydrogenase
C2I06_14415	COG0778	Nitroreductase
C2I06_14420	COG1115	amino acid carrier protein
C2I06_14430	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C2I06_14440	COG0561	phosphatase activity
C2I06_14470	COG1164	Oligoendopeptidase f
C2I06_14475	COG2723	6-phospho-beta-galactosidase activity
C2I06_14480	COG2188	Transcriptional regulator
C2I06_14490	COG0840	transmembrane signaling receptor activity
C2I06_14490	COG5278	phosphoserine phosphatase activity
C2I06_14505	COG1695	Transcriptional regulator
C2I06_14520	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2I06_14520	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2I06_14525	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2I06_14560	COG2124	cytochrome p450
C2I06_14565	COG1028	Short-chain dehydrogenase reductase Sdr
C2I06_14570	COG2814	Major facilitator Superfamily
C2I06_14575	COG0383	alpha-mannosidase activity
C2I06_14595	COG4753	response regulator
C2I06_14595	COG2207	Transcriptional regulator
C2I06_14600	COG2972	Histidine kinase
C2I06_14615	COG0395	ABC-type sugar transport system, permease component
C2I06_14625	COG2207	Transcriptional regulator
C2I06_14635	COG0477	Major facilitator Superfamily
C2I06_14640	COG1309	transcriptional regulator
C2I06_14645	COG0778	Nitroreductase
C2I06_14650	COG2207	Transcriptional regulator
C2I06_14650	COG4753	response regulator
C2I06_14655	COG2972	Histidine kinase
C2I06_14670	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C2I06_14675	COG0395	ABC-type sugar transport system, permease component
C2I06_14680	COG4209	transmembrane transport
C2I06_14690	COG2188	Transcriptional regulator
C2I06_14695	COG4948	Mandelate Racemase Muconate Lactonizing
C2I06_14700	COG1263	PTS System
C2I06_14700	COG2190	(PTS) system
C2I06_14700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I06_14705	COG1525	nuclease
C2I06_14710	COG1178	ABC-type Fe3 transport system permease component
C2I06_14715	COG3842	ATPase activity
C2I06_14720	COG1840	ABC-type Fe3 transport system, periplasmic component
C2I06_14725	COG2207	Transcriptional regulator
C2I06_14725	COG4753	response regulator
C2I06_14735	COG1263	PTS System
C2I06_14735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I06_14750	COG3835	regulator
C2I06_14755	COG1929	Belongs to the glycerate kinase type-1 family
C2I06_14760	COG2610	gluconate transmembrane transporter activity
C2I06_14780	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2I06_14785	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2I06_14790	COG3842	ATPase activity
C2I06_14795	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C2I06_14805	COG1988	membrane-bound metal-dependent
C2I06_14825	COG3345	alpha-galactosidase
C2I06_14835	COG0395	ABC-type sugar transport system, permease component
C2I06_14840	COG1175	transmembrane transport
C2I06_14875	COG3250	beta-galactosidase activity
C2I06_14880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2I06_14885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I06_14890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I06_14895	COG2197	response regulator
C2I06_14900	COG2200	EAL domain
C2I06_14900	COG2199	diguanylate cyclase activity
C2I06_14905	COG3279	Response regulator of the LytR AlgR family
C2I06_14915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I06_14940	COG0191	fructose-bisphosphate aldolase activity
C2I06_14960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I06_14965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2I06_14975	COG1316	TRANSCRIPTIONal
C2I06_14980	COG2340	Cysteine-rich secretory protein family
C2I06_15010	COG2153	protein acetylation
C2I06_15025	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2I06_15035	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2I06_15045	COG2188	Transcriptional regulator
C2I06_15050	COG2368	4-hydroxyphenylacetate
C2I06_15080	COG0395	ABC-type sugar transport system, permease component
C2I06_15085	COG1175	transmembrane transport
C2I06_15095	COG1940	carbohydrate kinase activity
C2I06_15120	COG2720	vancomycin resistance protein
C2I06_15125	COG0346	lactoylglutathione lyase activity
C2I06_15140	COG1609	Transcriptional regulator
C2I06_15155	COG2160	L-arabinose isomerase activity
C2I06_15185	COG2079	MmgE PrpD family protein
C2I06_15195	COG1126	abc transporter atp-binding protein
C2I06_15200	COG0765	amino acid transport
C2I06_15205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2I06_15215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2I06_15220	COG0436	Aminotransferase
C2I06_15225	COG0371	Dehydrogenase
C2I06_15240	COG4895	conserved protein (DUF2196)
C2I06_15255	COG4412	M6 family metalloprotease domain protein
C2I06_15255	COG3291	Pkd domain containing protein
C2I06_15260	COG1846	Transcriptional regulator
C2I06_15270	COG2814	Major facilitator Superfamily
C2I06_15275	COG0395	ABC-type sugar transport system, permease component
C2I06_15280	COG1175	transmembrane transport
C2I06_15290	COG0165	Argininosuccinate lyase
C2I06_15300	COG0840	transmembrane signaling receptor activity
C2I06_15310	COG1012	belongs to the aldehyde dehydrogenase family
C2I06_15315	COG2188	Transcriptional regulator
C2I06_15320	COG2222	sugar isomerase
C2I06_15325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2I06_15335	COG1126	abc transporter atp-binding protein
C2I06_15340	COG0765	amino acid transport
C2I06_15355	COG0395	ABC-type sugar transport system, permease component
C2I06_15360	COG4209	transmembrane transport
C2I06_15370	COG3279	Response regulator of the LytR AlgR family
C2I06_15375	COG2972	Histidine kinase
C2I06_15380	COG0800	Aldolase
C2I06_15385	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2I06_15395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2I06_15400	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I06_15400	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I06_15420	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C2I06_15460	COG1131	(ABC) transporter
C2I06_15465	COG2205	protein histidine kinase activity
C2I06_15470	COG0745	RESPONSE REGULATOR receiver
C2I06_15475	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C2I06_15485	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2I06_15490	COG3716	PTS system mannose fructose sorbose family IID component
C2I06_15495	COG3715	PTS system
C2I06_15505	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I06_15505	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I06_15510	COG1846	Transcriptional regulator
C2I06_15510	COG1940	carbohydrate kinase activity
C2I06_15525	COG4821	SIS domain
C2I06_15535	COG1402	creatininase
C2I06_15555	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I06_15560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I06_15570	COG1141	Ferredoxin
C2I06_15575	COG0402	S-adenosylhomocysteine deaminase activity
C2I06_15580	COG0402	S-adenosylhomocysteine deaminase activity
C2I06_15595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2I06_15615	COG2271	Major facilitator Superfamily
C2I06_15620	COG4948	Mandelate Racemase Muconate Lactonizing
C2I06_15625	COG0800	Aldolase
C2I06_15630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2I06_15635	COG1414	Transcriptional regulator
C2I06_15650	COG1522	sequence-specific DNA binding
C2I06_15655	COG1263	PTS System
C2I06_15655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I06_15655	COG2190	(PTS) system
C2I06_15660	COG3711	transcriptional antiterminator
C2I06_15670	COG1609	Transcriptional regulator
C2I06_15675	COG1694	Mazg nucleotide pyrophosphohydrolase
C2I06_15680	COG3420	alginic acid biosynthetic process
C2I06_15685	COG1737	Transcriptional regulator
C2I06_15705	COG2081	HI0933 family
C2I06_15715	COG1522	sequence-specific DNA binding
C2I06_15730	COG3716	PTS system mannose fructose sorbose family IID component
C2I06_15735	COG3716	PTS system mannose fructose sorbose family IID component
C2I06_15745	COG1940	carbohydrate kinase activity
C2I06_15760	COG4821	SIS domain
C2I06_15770	COG1609	Transcriptional regulator
C2I06_15785	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2I06_15800	COG3764	Sortase (surface protein transpeptidase)
C2I06_15830	COG0543	2 iron, 2 sulfur cluster binding
C2I06_15835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2I06_15845	COG2814	Major facilitator Superfamily
C2I06_15855	COG0679	Auxin Efflux Carrier
C2I06_15860	COG0281	malic enzyme
C2I06_15890	COG0402	S-adenosylhomocysteine deaminase activity
C2I06_15900	COG1263	PTS System
C2I06_15900	COG2190	(PTS) system
C2I06_15900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I06_15905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2I06_15910	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2I06_15915	COG1609	Transcriptional regulator
C2I06_15935	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2I06_15950	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I06_15965	COG1216	Glycosyl transferase, family 2
C2I06_15990	COG1216	Glycosyl transferase, family 2
C2I06_16010	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2I06_16015	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C2I06_16020	COG4464	protein tyrosine phosphatase activity
C2I06_16025	COG0489	protein tyrosine kinase activity
C2I06_16030	COG3944	biosynthesis protein
C2I06_16040	COG1396	sequence-specific DNA binding
C2I06_16050	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C2I06_16060	COG0662	Cupin 2, conserved barrel domain protein
C2I06_16060	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C2I06_16065	COG1132	(ABC) transporter
C2I06_16085	COG0438	transferase activity, transferring glycosyl groups
C2I06_16095	COG5039	Polysaccharide pyruvyl transferase
C2I06_16115	COG0438	transferase activity, transferring glycosyl groups
C2I06_16130	COG0438	transferase activity, transferring glycosyl groups
C2I06_16135	COG0438	transferase activity, transferring glycosyl groups
C2I06_16145	COG0438	transferase activity, transferring glycosyl groups
C2I06_16150	COG1215	transferase activity, transferring glycosyl groups
C2I06_16155	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C2I06_16160	COG0489	protein tyrosine kinase activity
C2I06_16165	COG3944	biosynthesis protein
C2I06_16170	COG0668	transmembrane transport
C2I06_16180	COG5578	integral membrane protein
C2I06_16190	COG0395	ABC-type sugar transport system, permease component
C2I06_16195	COG4209	transmembrane transport
C2I06_16200	COG1486	melibiose metabolic process
C2I06_16215	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C2I06_16215	COG2755	lipolytic protein G-D-S-L family
C2I06_16220	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C2I06_16220	COG2755	lipolytic protein G-D-S-L family
C2I06_16230	COG5002	protein histidine kinase activity
C2I06_16235	COG0745	RESPONSE REGULATOR receiver
C2I06_16240	COG2814	Major facilitator Superfamily
C2I06_16245	COG4978	Transcriptional regulator
C2I06_16245	COG0789	Transcriptional regulator
C2I06_16250	COG1846	Transcriptional regulator
C2I06_16255	COG1132	(ABC) transporter
C2I06_16280	COG3119	arylsulfatase activity
C2I06_16285	COG2190	(PTS) system
C2I06_16285	COG1263	PTS System
C2I06_16285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I06_16290	COG3711	transcriptional antiterminator
C2I06_16295	COG2190	(PTS) system
C2I06_16300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I06_16300	COG3711	transcriptional antiterminator
C2I06_16310	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2I06_16315	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2I06_16320	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2I06_16335	COG2002	toxin-antitoxin pair type II binding
C2I06_16340	COG3706	GGDEF domain
C2I06_16345	COG1742	UPF0060 membrane protein
C2I06_16365	COG1846	Transcriptional regulator
C2I06_16370	COG1566	PFAM secretion protein HlyD family protein
C2I06_16375	COG2814	Major facilitator Superfamily
C2I06_16385	COG0673	inositol 2-dehydrogenase activity
C2I06_16395	COG2814	Major facilitator Superfamily
C2I06_16400	COG0596	Alpha beta hydrolase
C2I06_16405	COG1309	transcriptional regulator
C2I06_16415	COG0667	Aldo Keto reductase
C2I06_16420	COG1940	carbohydrate kinase activity
C2I06_16425	COG2723	6-phospho-beta-galactosidase activity
C2I06_16430	COG3458	cephalosporin-C deacetylase activity
C2I06_16435	COG1609	Transcriptional regulator
C2I06_16440	COG0701	Predicted permease
C2I06_16460	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2I06_16465	COG1388	LysM domain
C2I06_16470	COG4191	Histidine kinase
C2I06_16475	COG0025	NhaP-type Na H and K H
C2I06_16505	COG1408	metallophosphoesterase
C2I06_16515	COG2197	response regulator
C2I06_16520	COG4585	Histidine kinase
C2I06_16525	COG0842	Transport permease protein
C2I06_16530	COG1131	(ABC) transporter
C2I06_16555	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2I06_16560	COG1028	Short-chain dehydrogenase reductase Sdr
C2I06_16565	COG0697	spore germination
C2I06_16570	COG1388	LysM domain
C2I06_16570	COG0791	NLP P60 protein
C2I06_16580	COG5522	Integral membrane protein (intg_mem_TP0381)
C2I06_16590	COG0460	homoserine dehydrogenase
C2I06_16605	COG2719	SpoVR family
C2I06_16610	COG0768	penicillin binding
C2I06_16615	COG3011	Protein conserved in bacteria
C2I06_16625	COG0791	NLP P60 protein
C2I06_16625	COG1388	LysM domain
C2I06_16635	COG4715	Zinc finger, swim domain protein
C2I06_16640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2I06_16670	COG4786	Flagellar basal body rod
C2I06_16675	COG4786	Flagellar basal body rod
C2I06_16680	COG1077	Cell shape determining protein MreB Mrl
C2I06_16685	COG1609	Transcriptional regulator
C2I06_16690	COG0739	heme binding
C2I06_16700	COG2385	sporulation resulting in formation of a cellular spore
C2I06_16705	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2I06_16715	COG4836	Membrane
C2I06_16720	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C2I06_16725	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C2I06_16730	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C2I06_16740	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C2I06_16745	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C2I06_16750	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C2I06_16755	COG0356	it plays a direct role in the translocation of protons across the membrane
C2I06_16765	COG1404	Belongs to the peptidase S8 family
C2I06_16770	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C2I06_16775	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C2I06_16785	COG0840	transmembrane signaling receptor activity
C2I06_16795	COG1971	Probably functions as a manganese efflux pump
C2I06_16800	COG0009	L-threonylcarbamoyladenylate synthase
C2I06_16815	COG1012	belongs to the aldehyde dehydrogenase family
C2I06_16820	COG0506	proline dehydrogenase activity
C2I06_16825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2I06_16830	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2I06_16830	COG1321	iron dependent repressor
C2I06_16835	COG1121	(ABC) transporter
C2I06_16840	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2I06_16855	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C2I06_16860	COG1366	Belongs to the anti-sigma-factor antagonist family
C2I06_16865	COG1253	flavin adenine dinucleotide binding
C2I06_16870	COG1253	flavin adenine dinucleotide binding
C2I06_16880	COG1435	thymidine kinase activity
C2I06_16890	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C2I06_16900	COG0191	fructose-bisphosphate aldolase activity
C2I06_16905	COG2204	response regulator
C2I06_16910	COG4821	SIS domain
C2I06_16915	COG0504	CTP synthase activity
C2I06_16920	COG3343	RNA polymerase activity
C2I06_16930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2I06_16940	COG3279	Response regulator of the LytR AlgR family
C2I06_16945	COG4555	ABC transporter
C2I06_16950	COG1668	transmembrane transport
C2I06_16990	COG0018	arginyl-trna synthetase
C2I06_16995	COG4506	Protein conserved in bacteria
C2I06_17000	COG0791	NLP P60 protein
C2I06_17000	COG3103	Sh3 type 3 domain protein
C2I06_17000	COG1388	LysM domain
C2I06_17005	COG0010	Belongs to the arginase family
C2I06_17010	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C2I06_17015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2I06_17030	COG1193	negative regulation of DNA recombination
C2I06_17040	COG1994	Peptidase M50
C2I06_17045	COG1942	4-Oxalocrotonate Tautomerase
C2I06_17050	COG3465	dGTPase activity
C2I06_17055	COG1078	dGTPase activity
C2I06_17060	COG4844	belongs to the
C2I06_17065	COG0477	Major facilitator Superfamily
C2I06_17080	COG0280	phosphate acetyltransferase
C2I06_17095	COG2363	Small membrane protein
C2I06_17110	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C2I06_17125	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2I06_17135	COG0314	molybdopterin synthase activity
C2I06_17140	COG0351	phosphomethylpyrimidine kinase
C2I06_17145	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2I06_17165	COG0561	phosphatase activity
C2I06_17170	COG1271	oxidase subunit
C2I06_17175	COG1294	oxidase, subunit
C2I06_17180	COG4988	ABC transporter
C2I06_17185	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2I06_17190	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2I06_17195	COG2226	methyltransferase
C2I06_17200	COG0492	ferredoxin-NADP+ reductase activity
C2I06_17205	COG1486	melibiose metabolic process
C2I06_17210	COG3610	response to peptide
C2I06_17215	COG2966	Psort location CytoplasmicMembrane, score
C2I06_17230	COG1131	(ABC) transporter
C2I06_17235	COG0686	Belongs to the AlaDH PNT family
C2I06_17240	COG2508	Transcriptional regulator
C2I06_17240	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C2I06_17250	COG1486	melibiose metabolic process
C2I06_17255	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2I06_17260	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2I06_17265	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2I06_17280	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2I06_17285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2I06_17295	COG0385	Bile acid
C2I06_17300	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2I06_17305	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2I06_17310	COG2723	6-phospho-beta-galactosidase activity
C2I06_17315	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2I06_17320	COG3711	transcriptional antiterminator
C2I06_17320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I06_17330	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2I06_17380	COG2508	Transcriptional regulator
C2I06_17390	COG0477	Major facilitator Superfamily
C2I06_17395	COG0534	Mate efflux family protein
C2I06_17405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2I06_17415	COG1609	Transcriptional regulator
C2I06_17430	COG1609	Transcriptional regulator
C2I06_17440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2I06_17445	COG1554	hydrolase, family 65, central catalytic
C2I06_17455	COG3833	ABC-type maltose transport systems, permease component
C2I06_17460	COG1175	transmembrane transport
C2I06_17465	COG2182	Extracellular solute-binding protein
C2I06_17470	COG1263	PTS System
C2I06_17470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I06_17475	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C2I06_17480	COG1122	ATPase activity
C2I06_17485	COG4721	ABC-type cobalt transport system, permease component
C2I06_17490	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C2I06_17495	COG0039	L-malate dehydrogenase activity
C2I06_17500	COG3695	enzyme binding
C2I06_17510	COG0411	ABC transporter
C2I06_17520	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2I06_17550	COG4176	ABC-type proline glycine betaine transport system permease component
C2I06_17560	COG3507	Belongs to the glycosyl hydrolase 43 family
C2I06_17575	COG1073	alpha beta
C2I06_17585	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C2I06_17590	COG1653	transport
C2I06_17600	COG4209	transmembrane transport
C2I06_17605	COG0395	ABC-type sugar transport system, permease component
C2I06_17610	COG2207	Transcriptional regulator
C2I06_17615	COG1609	Transcriptional regulator
C2I06_17620	COG2721	sulfolactate sulfo-lyase activity
C2I06_17625	COG1904	glucuronate isomerase
C2I06_17630	COG2755	lipolytic protein G-D-S-L family
C2I06_17630	COG0657	acetylesterase activity
C2I06_17635	COG2755	lipolytic protein G-D-S-L family
C2I06_17650	COG2814	Major facilitator Superfamily
C2I06_17680	COG2072	flavoprotein involved in K transport
C2I06_17715	COG2208	phosphoserine phosphatase activity
C2I06_17720	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C2I06_17725	COG0784	Response regulator, receiver
C2I06_17725	COG2198	Histidine kinase
C2I06_17725	COG2205	protein histidine kinase activity
C2I06_17735	COG4608	Belongs to the ABC transporter superfamily
C2I06_17740	COG0444	Belongs to the ABC transporter superfamily
C2I06_17745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2I06_17750	COG0601	transmembrane transport
C2I06_17755	COG4166	transmembrane transport
C2I06_17765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2I06_17770	COG4989	oxidoreductase activity
C2I06_17775	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2I06_17780	COG1320	monovalent cation:proton antiporter activity
C2I06_17785	COG2212	antiporter activity
C2I06_17790	COG1863	multisubunit Na H antiporter MnhE subunit
C2I06_17795	COG0651	ATP synthesis coupled electron transport
C2I06_17805	COG2111	Na H antiporter
C2I06_17820	COG0582	viral genome integration into host DNA
C2I06_17825	COG0124	histidyl-tRNA synthetase
C2I06_17830	COG3142	Participates in the control of copper homeostasis
C2I06_17835	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C2I06_17840	COG1609	Transcriptional regulator
C2I06_17845	COG3459	Glycosyltransferase 36 associated
C2I06_17855	COG0395	ABC-type sugar transport system, permease component
C2I06_17860	COG1175	transmembrane transport
C2I06_17870	COG5039	Polysaccharide pyruvyl transferase
C2I06_17875	COG1994	Peptidase M50
C2I06_17880	COG1397	ADP-ribosylglycohydrolase
C2I06_17900	COG4555	ABC transporter
C2I06_17910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2I06_17915	COG0450	alkyl hydroperoxide reductase
C2I06_17920	COG3634	alkyl hydroperoxide reductase activity
C2I06_17940	COG4166	transmembrane transport
C2I06_17945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I06_17945	COG3711	transcriptional antiterminator
C2I06_17950	COG2723	6-phospho-beta-galactosidase activity
C2I06_17960	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2I06_17965	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2I06_17970	COG3507	Belongs to the glycosyl hydrolase 43 family
C2I06_17975	COG0579	oxidoreductase
C2I06_17980	COG1464	Belongs to the NlpA lipoprotein family
C2I06_17990	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2I06_17995	COG1279	arginine transmembrane transporter activity
C2I06_18000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I06_18010	COG5566	PFAM Mor transcription activator
C2I06_18015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2I06_18020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2I06_18030	COG5002	protein histidine kinase activity
C2I06_18050	COG2824	Alkylphosphonate utilization operon protein PhnA
C2I06_18060	COG1126	abc transporter atp-binding protein
C2I06_18065	COG0765	amino acid transport
C2I06_18075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2I06_18080	COG2814	Major facilitator Superfamily
C2I06_18085	COG0733	neurotransmitter:sodium symporter activity
C2I06_18095	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
C2I06_18100	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2I06_18105	COG1696	Membrane protein involved in D-alanine export
C2I06_18110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2I06_18120	COG0745	RESPONSE REGULATOR receiver
C2I06_18125	COG5002	protein histidine kinase activity
C2I06_18135	COG0697	spore germination
C2I06_18140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I06_18150	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C2I06_18155	COG2169	Transcriptional regulator
C2I06_18165	COG1126	abc transporter atp-binding protein
C2I06_18170	COG0765	amino acid transport
C2I06_18175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2I06_18185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I06_18190	COG0697	spore germination
C2I06_18215	COG2223	nitrite transmembrane transporter activity
C2I06_18220	COG0109	protoheme IX farnesyltransferase activity
C2I06_18225	COG0746	molybdenum cofactor guanylyltransferase activity
C2I06_18230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2I06_18235	COG1763	Mo-molybdopterin cofactor biosynthetic process
C2I06_18245	COG0314	molybdopterin synthase activity
C2I06_18250	COG0303	'Molybdopterin
C2I06_18255	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2I06_18260	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2I06_18270	COG2181	nitrate reductase activity
C2I06_18275	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C2I06_18280	COG1140	nitrate reductase beta subunit
C2I06_18285	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C2I06_18290	COG4149	molybdate abc transporter
C2I06_18295	COG0725	ABC transporter, periplasmic molybdate-binding protein
C2I06_18310	COG1028	Short-chain dehydrogenase reductase Sdr
C2I06_18330	COG1595	DNA-templated transcription, initiation
C2I06_18360	COG0577	efflux transmembrane transporter activity
C2I06_18365	COG1136	(ABC) transporter
C2I06_18370	COG2329	Antibiotic biosynthesis monooxygenase
C2I06_18435	COG4841	protein insertion into membrane
C2I06_18445	COG1846	Transcriptional regulator
C2I06_18450	COG2723	6-phospho-beta-galactosidase activity
C2I06_18455	COG2190	(PTS) system
C2I06_18455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I06_18455	COG1263	PTS System
C2I06_18460	COG2190	(PTS) system
C2I06_18460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I06_18460	COG1263	PTS System
C2I06_18465	COG3711	transcriptional antiterminator
C2I06_18485	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2I06_18505	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C2I06_18515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2I06_18520	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C2I06_18525	COG4853	Protein conserved in bacteria
C2I06_18530	COG4863	YycH protein
C2I06_18535	COG5002	protein histidine kinase activity
C2I06_18540	COG0745	RESPONSE REGULATOR receiver
C2I06_18570	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2I06_18580	COG0305	Participates in initiation and elongation during chromosome replication
C2I06_18585	COG0359	binds to the 23S rRNA
C2I06_18590	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
C2I06_18595	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C2I06_18605	COG0360	Binds together with S18 to 16S ribosomal RNA
C2I06_18610	COG0438	transferase activity, transferring glycosyl groups
C2I06_18615	COG0012	GTP binding
C2I06_18620	COG4481	Protein conserved in bacteria
C2I06_18625	COG0668	transmembrane transport
C2I06_18640	COG1475	DNA binding
C2I06_18645	COG1192	Involved in chromosome partitioning
C2I06_18655	COG1475	DNA binding
C2I06_18675	COG1847	R3H domain protein
C2I06_18685	COG0594	ribonuclease P activity
C2I06_18690	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C2I06_18700	COG0592	DNA-directed DNA polymerase activity
C2I06_18705	COG2501	S4 domain
C2I06_18710	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C2I06_18720	COG0187	DNA topoisomerase II activity
C2I06_18725	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C2I06_18730	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2I06_18765	COG0516	GMP reductase activity
C2I06_18765	COG0517	IMP dehydrogenase activity
C2I06_18780	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C2I06_18785	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C2I06_18795	COG1428	Deoxynucleoside kinase
C2I06_18800	COG1428	Deoxynucleoside kinase
C2I06_18805	COG0352	thiamine-phosphate diphosphorylase activity
C2I06_18815	COG2104	thiamine diphosphate biosynthetic process
C2I06_18820	COG2022	thiamine diphosphate biosynthetic process
C2I06_18825	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2I06_18830	COG3858	chitin binding
C2I06_18830	COG1388	LysM domain
C2I06_18835	COG1335	isochorismatase
C2I06_18840	COG0590	tRNA wobble adenosine to inosine editing
C2I06_18850	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C2I06_18855	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C2I06_18860	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C2I06_18900	COG1943	Transposase
C2I06_18910	COG1982	Orn Lys Arg decarboxylase major
C2I06_18920	COG3870	Protein conserved in bacteria
C2I06_18925	COG1728	Protein conserved in bacteria
C2I06_18930	COG0470	DNA polymerase III
C2I06_18935	COG1774	PSP1 C-terminal conserved region
C2I06_18940	COG4467	Involved in initiation control of chromosome replication
C2I06_18945	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C2I06_18950	COG2827	Endonuclease containing a URI domain
C2I06_18955	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C2I06_18960	COG2002	toxin-antitoxin pair type II binding
C2I06_18970	COG0084	hydrolase, TatD family'
C2I06_18975	COG3583	domain protein
C2I06_18975	COG3584	3D domain protein
C2I06_18985	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C2I06_18995	COG4466	Protein conserved in bacteria
C2I06_19005	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C2I06_19010	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2I06_19015	COG0251	oxidation-reduction process
C2I06_19020	COG2088	sporulation resulting in formation of a cellular spore
C2I06_19025	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2I06_19030	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2I06_19035	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C2I06_19040	COG0193	aminoacyl-tRNA hydrolase activity
C2I06_19050	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2I06_19055	COG2002	toxin-antitoxin pair type II binding
C2I06_19060	COG2188	Transcriptional regulator
C2I06_19070	COG2244	polysaccharide biosynthetic process
C2I06_19075	COG3956	TIGRFAM MazG family protein
C2I06_19080	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C2I06_19095	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C2I06_19100	COG1098	S1 RNA binding domain
C2I06_19110	COG2208	phosphoserine phosphatase activity
C2I06_19115	COG2304	oxidoreductase activity
C2I06_19120	COG0515	serine threonine protein kinase
C2I06_19125	COG0037	tRNA processing
C2I06_19135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2I06_19140	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C2I06_19145	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C2I06_19150	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2I06_19155	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2I06_19160	COG0512	Glutamine amidotransferase of anthranilate synthase
C2I06_19165	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2I06_19170	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2I06_19175	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2I06_19180	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C2I06_19185	COG1396	sequence-specific DNA binding
C2I06_19190	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2I06_19195	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C2I06_19280	COG3880	PFAM UvrB UvrC protein
C2I06_19285	COG3869	Catalyzes the specific phosphorylation of arginine residues in
C2I06_19290	COG0542	response to heat
C2I06_19295	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C2I06_19300	COG4956	integral membrane protein (PIN domain superfamily)
C2I06_19305	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C2I06_19310	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C2I06_19315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2I06_19320	COG1045	serine acetyltransferase
C2I06_19325	COG0215	cysteine-tRNA ligase activity
C2I06_19335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2I06_19340	COG3688	RNA-binding protein containing a PIN domain
C2I06_19350	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C2I06_19355	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2I06_19360	COG0250	Participates in transcription elongation, termination and antitermination
C2I06_19370	COG0081	regulation of translation
C2I06_19380	COG0222	ribosome binding
C2I06_19385	COG2813	Specifically methylates the guanine in position
C2I06_19395	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C2I06_19400	COG1358	cellular component organization or biogenesis
C2I06_19405	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C2I06_19410	COG0049	tRNA binding
C2I06_19420	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2I06_19425	COG0051	transcription antitermination factor activity, RNA binding
C2I06_19430	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C2I06_19435	COG0088	Forms part of the polypeptide exit tunnel
C2I06_19445	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C2I06_19450	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C2I06_19455	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C2I06_19460	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C2I06_19465	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C2I06_19470	COG0255	Belongs to the universal ribosomal protein uL29 family
C2I06_19475	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C2I06_19480	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C2I06_19505	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C2I06_19510	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C2I06_19515	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C2I06_19520	COG1841	ribosomal large subunit assembly
C2I06_19530	COG0201	protein transport
C2I06_19535	COG0563	adenylate kinase activity
C2I06_19540	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C2I06_19545	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2I06_19550	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C2I06_19560	COG0202	RNA polymerase activity
C2I06_19565	COG0203	ribosomal protein L17
C2I06_19570	COG1122	ATPase activity
C2I06_19575	COG1122	ATPase activity
C2I06_19580	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C2I06_19590	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C2I06_19610	COG2723	6-phospho-beta-galactosidase activity
C2I06_19615	COG2190	(PTS) system
C2I06_19615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I06_19615	COG1263	PTS System
C2I06_19625	COG2190	(PTS) system
C2I06_19675	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2I06_19680	COG0489	protein tyrosine kinase activity
C2I06_19690	COG0726	polysaccharide deacetylase
C2I06_19765	COG1595	DNA-templated transcription, initiation
C2I06_19770	COG5662	AntiSigma factor
C2I06_19775	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C2I06_19780	COG4856	YbbR-like protein
C2I06_19785	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2I06_19790	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2I06_19810	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C2I06_19820	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C2I06_19870	COG0463	Glycosyl transferase, family 2
C2I06_19910	COG1846	Transcriptional regulator
C2I06_19935	COG1846	Transcriptional regulator
C2I06_19945	COG0778	Nitroreductase
C2I06_19960	COG0745	RESPONSE REGULATOR receiver
C2I06_19965	COG0642	Histidine kinase
C2I06_19985	COG1733	regulation of RNA biosynthetic process
C2I06_19995	COG1028	Short-chain dehydrogenase reductase Sdr
C2I06_20010	COG2807	transmembrane transport
C2I06_20020	COG4607	ABC-type enterochelin transport system periplasmic component
C2I06_20025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I06_20030	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I06_20035	COG1120	ATPase activity
C2I06_20050	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2I06_20060	COG0730	response to heat
C2I06_20075	COG2210	Belongs to the sulfur carrier protein TusA family
C2I06_20085	COG1114	Component of the transport system for branched-chain amino acids
C2I06_20090	COG2378	regulation of single-species biofilm formation
C2I06_20095	COG0519	Catalyzes the synthesis of GMP from XMP
C2I06_20100	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2I06_20110	COG1595	DNA-templated transcription, initiation
C2I06_20115	COG0492	ferredoxin-NADP+ reductase activity
C2I06_20120	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2I06_20130	COG0456	acetyltransferase
C2I06_20155	COG1595	DNA-templated transcription, initiation
C2I06_20165	COG1316	TRANSCRIPTIONal
C2I06_20175	COG0454	-acetyltransferase
C2I06_20200	COG1011	Hydrolase
C2I06_20210	COG1609	Transcriptional regulator
C2I06_20215	COG2182	Extracellular solute-binding protein
C2I06_20220	COG1175	transmembrane transport
C2I06_20225	COG3833	ABC-type maltose transport systems, permease component
C2I06_20230	COG1874	Beta-galactosidase
C2I06_20235	COG1028	Short-chain dehydrogenase reductase Sdr
C2I06_20245	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2I06_20250	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2I06_20255	COG0583	DNA-binding transcription factor activity
C2I06_20270	COG0175	sulfate reduction
C2I06_20280	COG2046	Belongs to the sulfate adenylyltransferase family
C2I06_20285	COG0529	Catalyzes the synthesis of activated sulfate
C2I06_20310	COG5002	protein histidine kinase activity
C2I06_20325	COG1309	transcriptional regulator
C2I06_20330	COG2814	Major facilitator Superfamily
C2I06_20355	COG1028	Short-chain dehydrogenase reductase Sdr
C2I06_20370	COG2404	hydrolase activity, acting on ester bonds
C2I06_20385	COG1657	PFAM Prenyltransferase squalene oxidase
C2I06_20390	COG0017	Asparaginyl-tRNA synthetase
C2I06_20395	COG3386	PFAM SMP-30 Gluconolaconase
C2I06_20405	COG0659	secondary active sulfate transmembrane transporter activity
C2I06_20415	COG3620	sequence-specific DNA binding
C2I06_20425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I06_20425	COG2190	(PTS) system
C2I06_20425	COG1263	PTS System
C2I06_20450	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2I06_20470	COG4149	molybdate abc transporter
C2I06_20475	COG0725	ABC transporter, periplasmic molybdate-binding protein
C2I06_20480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2I06_20515	COG1252	NADH dehydrogenase
C2I06_20530	COG1122	ATPase activity
C2I06_20550	COG2244	polysaccharide biosynthetic process
C2I06_20555	COG0297	glycogen (starch) synthase activity
C2I06_20555	COG0438	transferase activity, transferring glycosyl groups
C2I06_20560	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2I06_20565	COG3307	-O-antigen
C2I06_20570	COG3206	protein involved in exopolysaccharide biosynthesis
C2I06_20575	COG1215	transferase activity, transferring glycosyl groups
C2I06_20580	COG0438	transferase activity, transferring glycosyl groups
C2I06_20585	COG1959	2 iron, 2 sulfur cluster binding
C2I06_20605	COG2362	D-Aminopeptidase
C2I06_20610	COG0601	transmembrane transport
C2I06_20615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2I06_20620	COG0444	Belongs to the ABC transporter superfamily
C2I06_20625	COG4166	transmembrane transport
C2I06_20630	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2I06_20635	COG4948	Mandelate Racemase Muconate Lactonizing
C2I06_20640	COG0791	NLP P60 protein
C2I06_20645	COG4608	Belongs to the ABC transporter superfamily
C2I06_20655	COG1120	ATPase activity
C2I06_20670	COG0667	Aldo Keto reductase
C2I06_20675	COG0129	dihydroxy-acid dehydratase activity
C2I06_20680	COG0628	permease
C2I06_20685	COG0789	Transcriptional regulator
C2I06_20690	COG1253	flavin adenine dinucleotide binding
C2I06_20700	COG3711	transcriptional antiterminator
C2I06_20705	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I06_20710	COG0246	Mannitol dehydrogenase
C2I06_20715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2I06_20720	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2I06_20725	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2I06_20740	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I06_20745	COG4605	iron ion homeostasis
C2I06_20750	COG4604	ABC transporter, ATP-binding protein
C2I06_20755	COG4607	ABC-type enterochelin transport system periplasmic component
C2I06_20760	COG0673	inositol 2-dehydrogenase activity
C2I06_20765	COG1940	carbohydrate kinase activity
C2I06_20770	COG5002	protein histidine kinase activity
C2I06_20770	COG3850	Histidine kinase
C2I06_20775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2I06_20780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2I06_20785	COG0242	peptide deformylase activity
C2I06_20810	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2I06_20815	COG1177	transmembrane transport
C2I06_20820	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2I06_20830	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2I06_20845	COG2861	carbohydrate metabolic process
C2I06_20850	COG0668	transmembrane transport
C2I06_20855	COG0569	domain protein
C2I06_20860	COG0783	Belongs to the Dps family
C2I06_20865	COG0772	Belongs to the SEDS family
C2I06_20870	COG2239	Acts as a magnesium transporter
C2I06_20875	COG0402	S-adenosylhomocysteine deaminase activity
C2I06_20885	COG1489	DNA binding
C2I06_20890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2I06_20895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I06_20900	COG1120	ATPase activity
C2I06_20905	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C2I06_20910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C2I06_20920	COG1492	cobalamin metabolic process
C2I06_20925	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C2I06_20930	COG0588	phosphoglycerate mutase activity
C2I06_20940	COG2096	Adenosyltransferase
C2I06_20960	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2I06_20970	COG0513	Belongs to the DEAD box helicase family
C2I06_20975	COG3402	PFAM membrane-flanked domain
C2I06_20980	COG3428	Bacterial PH domain
C2I06_20985	COG0705	Rhomboid family
C2I06_20990	COG0736	holo-[acyl-carrier-protein] synthase activity
C2I06_20995	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C2I06_21005	COG0864	Transcriptional regulator
C2I06_21010	COG2337	Toxic component of a toxin-antitoxin (TA) module
C2I06_21015	COG1366	Belongs to the anti-sigma-factor antagonist family
C2I06_21020	COG2172	sigma factor antagonist activity
C2I06_21025	COG2208	phosphoserine phosphatase activity
C2I06_21030	COG1366	Belongs to the anti-sigma-factor antagonist family
C2I06_21035	COG2172	sigma factor antagonist activity
C2I06_21040	COG1191	sigma factor activity
C2I06_21045	COG2208	phosphoserine phosphatase activity
C2I06_21050	COG2183	response to ionizing radiation
C2I06_21060	COG3091	SprT-like family
C2I06_21140	COG0802	atpase or kinase
C2I06_21145	COG1214	PFAM Peptidase M22, glycoprotease
C2I06_21150	COG0456	acetyltransferase
C2I06_21160	COG0488	(ABC) transporter
C2I06_21165	COG0315	cyclic pyranopterin monophosphate synthase activity
C2I06_21170	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C2I06_21180	COG1266	CAAX protease self-immunity
C2I06_21185	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C2I06_21190	COG0459	protein refolding
C2I06_21200	COG1396	sequence-specific DNA binding
C2I06_21270	COG0346	lactoylglutathione lyase activity
C2I06_21315	COG3715	PTS system
C2I06_21320	COG3716	PTS system mannose fructose sorbose family IID component
C2I06_21325	COG0673	inositol 2-dehydrogenase activity
C2I06_21330	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C2I06_21335	COG0277	FAD linked oxidase domain protein
C2I06_21355	COG0733	neurotransmitter:sodium symporter activity
C2I06_21365	COG3290	protein histidine kinase activity
C2I06_21370	COG4565	transcriptional regulatory protein
C2I06_21380	COG0281	malic enzyme
C2I06_21395	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C2I06_21410	COG3842	ATPase activity
C2I06_21420	COG1533	DNA photolyase activity
C2I06_21430	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2I06_21435	COG3871	stress protein (general stress protein 26)
C2I06_21440	COG4294	response to UV
C2I06_21445	COG4294	response to UV
C2I06_21455	COG2211	Major facilitator Superfamily
C2I06_21465	COG0583	DNA-binding transcription factor activity
C2I06_21470	COG1473	amidohydrolase
C2I06_21475	COG1288	antiporter activity
C2I06_21485	COG0702	epimerase
C2I06_21490	COG2188	Transcriptional regulator
C2I06_21495	COG2222	sugar isomerase
C2I06_21500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2I06_21505	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2I06_21535	COG1312	Catalyzes the dehydration of D-mannonate
C2I06_21545	COG1904	glucuronate isomerase
C2I06_21555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I06_21555	COG1263	PTS System
C2I06_21555	COG2190	(PTS) system
C2I06_21560	COG2723	6-phospho-beta-galactosidase activity
C2I06_21565	COG3711	transcriptional antiterminator
C2I06_21570	COG2310	stress, protein
C2I06_21575	COG0714	Associated with various cellular activities
C2I06_21580	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
C2I06_21585	COG1305	Transglutaminase-like
C2I06_21590	COG0519	Catalyzes the synthesis of GMP from XMP
C2I06_21590	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2I06_21595	COG0730	response to heat
C2I06_21600	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C2I06_21605	COG0517	IMP dehydrogenase activity
C2I06_21610	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2I06_21610	COG0574	Belongs to the PEP-utilizing enzyme family
C2I06_21615	COG2252	PERMEase
C2I06_21620	COG3711	transcriptional antiterminator
C2I06_21625	COG2190	(PTS) system
C2I06_21625	COG1263	PTS System
C2I06_21625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I06_21645	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2I06_21690	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
C2I06_21700	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2I06_21705	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2I06_21710	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2I06_21715	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C2I06_21720	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2I06_21725	COG0047	phosphoribosylformylglycinamidine synthase activity
C2I06_21735	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C2I06_21745	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2I06_21750	COG0138	bifunctional purine biosynthesis protein purh
C2I06_21755	COG0151	Belongs to the GarS family
C2I06_21760	COG1028	Short-chain dehydrogenase reductase Sdr
C2I06_21775	COG1470	cell adhesion involved in biofilm formation
C2I06_21780	COG4496	protein, YerC YecD
C2I06_21785	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
C2I06_21790	COG0210	DNA helicase
C2I06_21795	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C2I06_21800	COG4851	CamS sex pheromone cAM373 precursor
C2I06_21805	COG5506	Protein of unknown function (DUF1694)
C2I06_21810	COG1764	response to oxidative stress
C2I06_21815	COG1846	Transcriptional regulator
C2I06_21820	COG2720	vancomycin resistance protein
C2I06_21825	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2I06_21835	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2I06_21855	COG1595	DNA-templated transcription, initiation
C2I06_21875	COG1597	lipid kinase activity
C2I06_21885	COG0583	DNA-binding transcription factor activity
C2I06_21890	COG2814	Major facilitator Superfamily
C2I06_21895	COG0604	alcohol dehydrogenase
C2I06_21910	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2I06_21915	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
C2I06_21920	COG2205	protein histidine kinase activity
C2I06_21930	COG0456	acetyltransferase
C2I06_21935	COG1388	LysM domain
C2I06_21935	COG3584	3D domain protein
C2I06_21955	COG2972	Histidine kinase
C2I06_21980	COG0166	Belongs to the GPI family
C2I06_21985	COG1733	regulation of RNA biosynthetic process
C2I06_21990	COG2514	catechol 2,3-dioxygenase activity
C2I06_21995	COG1366	Belongs to the anti-sigma-factor antagonist family
C2I06_22005	COG1785	Belongs to the alkaline phosphatase family
C2I06_22010	COG1794	racemase activity, acting on amino acids and derivatives
C2I06_22015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I06_22020	COG3480	Lon protease (S16) C-terminal proteolytic domain
C2I06_22030	COG3279	Response regulator of the LytR AlgR family
C2I06_22050	COG1695	Transcriptional regulator
C2I06_22075	COG0515	serine threonine protein kinase
C2I06_22080	COG1132	(ABC) transporter
C2I06_22095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2I06_22105	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C2I06_22115	COG2814	Major facilitator Superfamily
C2I06_22120	COG0527	aspartate kinase activity
C2I06_22130	COG0765	amino acid transport
C2I06_22135	COG1126	abc transporter atp-binding protein
C2I06_22145	COG1473	amidohydrolase
C2I06_22150	COG1473	amidohydrolase
C2I06_22155	COG0444	Belongs to the ABC transporter superfamily
C2I06_22160	COG4608	Belongs to the ABC transporter superfamily
C2I06_22165	COG0601	transmembrane transport
C2I06_22170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2I06_22180	COG1132	(ABC) transporter
C2I06_22185	COG1132	(ABC) transporter
C2I06_22190	COG2357	RelA SpoT domain protein
C2I06_22195	COG0513	Belongs to the DEAD box helicase family
C2I06_22210	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2I06_22215	COG0697	spore germination
C2I06_22245	COG2197	response regulator
C2I06_22250	COG2244	polysaccharide biosynthetic process
C2I06_22265	COG0598	Magnesium transport protein CorA
C2I06_22270	COG1607	acyl-coa hydrolase
C2I06_22280	COG0670	Belongs to the BI1 family
C2I06_22285	COG1970	mechanosensitive ion channel activity
C2I06_22290	COG1254	Belongs to the acylphosphatase family
C2I06_22300	COG2309	aminopeptidase activity
C2I06_22305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2I06_22310	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2I06_22310	COG0551	DNA topoisomerase type I activity
C2I06_22320	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2I06_22325	COG1360	Flagellar Motor Protein
C2I06_22330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2I06_22330	COG1522	sequence-specific DNA binding
C2I06_22335	COG2313	pseudouridylate synthase activity
C2I06_22340	COG1396	sequence-specific DNA binding
C2I06_22355	COG1396	sequence-specific DNA binding
C2I06_22360	COG2188	Transcriptional regulator
C2I06_22365	COG0693	protein deglycase activity
C2I06_22370	COG0024	Methionine aminopeptidase
C2I06_22375	COG4840	Belongs to the UPF0435 family
C2I06_22380	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2I06_22390	COG1295	ribonuclease BN
C2I06_22395	COG2217	Heavy metal translocating P-type atpase
C2I06_22400	COG0477	Major facilitator Superfamily
C2I06_22405	COG0387	Pfam Sodium calcium exchanger
C2I06_22410	COG2364	Membrane
C2I06_22420	COG0535	radical SAM domain protein
C2I06_22435	COG1309	transcriptional regulator
C2I06_22455	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C2I06_22460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I06_22470	COG1959	2 iron, 2 sulfur cluster binding
C2I06_22485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2I06_22490	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2I06_22540	COG2204	response regulator
C2I06_22565	COG0463	Glycosyl transferase, family 2
C2I06_22570	COG0562	UDP-galactopyranose mutase
C2I06_22610	COG4842	Belongs to the WXG100 family
C2I06_22615	COG5417	Belongs to the EsaB family
C2I06_22620	COG4499	WXG100 protein secretion system (Wss), protein YukC
C2I06_22625	COG0433	COG0433 Predicted ATPase
C2I06_22625	COG1674	ftsk spoiiie
C2I06_22630	COG1511	domain protein
C2I06_22640	COG0488	(ABC) transporter
C2I06_22645	COG3940	Belongs to the glycosyl hydrolase 43 family
C2I06_22655	COG0737	Belongs to the 5'-nucleotidase family
C2I06_22665	COG4191	Histidine kinase
C2I06_22675	COG4807	Protein conserved in bacteria
C2I06_22685	COG0583	DNA-binding transcription factor activity
C2I06_22715	COG1125	glycine betaine transport
C2I06_22715	COG0517	IMP dehydrogenase activity
C2I06_22720	COG1174	glycine betaine transport
C2I06_22735	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2I06_22740	COG0573	inorganic phosphate transmembrane transporter activity
C2I06_22745	COG0581	inorganic phosphate transmembrane transporter activity
C2I06_22755	COG0704	Plays a role in the regulation of phosphate uptake
C2I06_22770	COG4753	response regulator
C2I06_22770	COG2207	Transcriptional regulator
C2I06_22775	COG4213	ABC transporter substrate-binding protein
C2I06_22780	COG1129	ABC transporter
C2I06_22785	COG4214	carbohydrate transport
C2I06_22790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2I06_22795	COG2211	Major facilitator Superfamily
C2I06_22815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2I06_22825	COG0702	epimerase
C2I06_22830	COG1733	regulation of RNA biosynthetic process
C2I06_22840	COG0765	amino acid transport
C2I06_22855	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2I06_22860	COG0322	excinuclease ABC activity
C2I06_22880	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C2I06_22885	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2I06_22890	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C2I06_22895	COG4260	virion core protein, lumpy skin disease virus
C2I06_22905	COG0534	Mate efflux family protein
C2I06_22930	COG3534	alpha-L-arabinofuranosidase
C2I06_22940	COG1780	Probably involved in ribonucleotide reductase function
C2I06_22945	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2I06_22950	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2I06_22955	COG1595	DNA-templated transcription, initiation
C2I06_22970	COG1132	(ABC) transporter
C2I06_22975	COG1132	(ABC) transporter
C2I06_23000	COG0840	transmembrane signaling receptor activity
C2I06_23020	COG3275	phosphorelay sensor kinase activity
C2I06_23025	COG3279	Response regulator of the LytR AlgR family
C2I06_23030	COG2223	nitrite transmembrane transporter activity
C2I06_23040	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
C2I06_23045	COG3853	Toxic anion resistance protein (TelA)
C2I06_23050	COG0384	phenazine biosynthesis protein PhzF
C2I06_23055	COG4708	membrane
C2I06_23065	COG1136	(ABC) transporter
C2I06_23070	COG0577	efflux transmembrane transporter activity
C2I06_23070	COG1136	(ABC) transporter
C2I06_23075	COG0745	RESPONSE REGULATOR receiver
C2I06_23080	COG5002	protein histidine kinase activity
C2I06_23080	COG3850	Histidine kinase
C2I06_23085	COG1607	acyl-coa hydrolase
C2I06_23100	COG0683	leucine binding
C2I06_23105	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2I06_23125	COG2706	6-phosphogluconolactonase activity
C2I06_23130	COG3507	Belongs to the glycosyl hydrolase 43 family
C2I06_23140	COG2137	regulation of response to DNA damage stimulus
C2I06_23160	COG1988	membrane-bound metal-dependent
C2I06_23165	COG1194	a g-specific adenine glycosylase
C2I06_23175	COG1028	Short-chain dehydrogenase reductase Sdr
C2I06_23195	COG1132	(ABC) transporter
C2I06_23200	COG4129	membrane
C2I06_23205	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2I06_23215	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2I06_23220	COG0735	belongs to the Fur family
C2I06_23330	COG0398	Pfam SNARE associated Golgi protein
C2I06_23335	COG0745	RESPONSE REGULATOR receiver
C2I06_23340	COG0642	Histidine kinase
C2I06_23340	COG5002	protein histidine kinase activity
C2I06_23360	COG1132	(ABC) transporter
C2I06_23370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I06_23395	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2I06_23410	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2I06_23415	COG2723	6-phospho-beta-galactosidase activity
C2I06_23420	COG3711	transcriptional antiterminator
C2I06_23420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I06_23465	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C2I06_23480	COG1304	FMN binding
C2I06_23490	COG1846	Transcriptional regulator
C2I06_23505	COG0477	Major facilitator Superfamily
C2I06_23510	COG3443	Belongs to the bacterial solute-binding protein 9 family
C2I06_23515	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2I06_23515	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2I06_23540	COG0456	acetyltransferase
C2I06_23540	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C2I06_23545	COG0789	Transcriptional regulator
C2I06_23550	COG0697	spore germination
C2I06_23560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2I06_23565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I06_23570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I06_23580	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C2I06_23585	COG4977	sequence-specific DNA binding
C2I06_23590	COG2755	lipolytic protein G-D-S-L family
C2I06_23595	COG2207	Transcriptional regulator
C2I06_23600	COG1653	transport
C2I06_23605	COG4209	transmembrane transport
C2I06_23610	COG0395	ABC-type sugar transport system, permease component
C2I06_23625	COG5578	integral membrane protein
C2I06_23630	COG0745	RESPONSE REGULATOR receiver
C2I06_23635	COG2205	protein histidine kinase activity
C2I06_23640	COG1136	(ABC) transporter
C2I06_23650	COG1902	pentaerythritol trinitrate reductase activity
C2I06_23655	COG3711	transcriptional antiterminator
C2I06_23660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I06_23660	COG1263	PTS System
C2I06_23660	COG2190	(PTS) system
C2I06_23665	COG2723	6-phospho-beta-galactosidase activity
C2I06_23670	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C2I06_23675	COG1984	allophanate hydrolase subunit 2
C2I06_23680	COG2814	Major facilitator Superfamily
C2I06_23700	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
C2I06_23735	COG2723	6-phospho-beta-galactosidase activity
C2I06_23785	COG0745	RESPONSE REGULATOR receiver
C2I06_23810	COG1846	Transcriptional regulator
C2I06_23815	COG0346	lactoylglutathione lyase activity
C2I06_23820	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2I06_23825	COG0346	lactoylglutathione lyase activity
C2I06_23830	COG0400	carboxylic ester hydrolase activity
C2I06_23835	COG0655	NAD(P)H dehydrogenase (quinone) activity
C2I06_23845	COG1378	Sugar-specific transcriptional regulator TrmB
C2I06_23850	COG2391	methyltransferase activity
C2I06_23865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2I06_23870	COG0431	NADPH-dependent FMN reductase
C2I06_23885	COG2972	Histidine kinase
C2I06_23890	COG2207	Transcriptional regulator
C2I06_23890	COG4753	response regulator
C2I06_23895	COG2814	Major facilitator Superfamily
C2I06_23895	COG0477	Major facilitator Superfamily
C2I06_23905	COG0741	lytic transglycosylase activity
C2I06_23910	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2I06_23925	COG4221	oxidoreductase activity
C2I06_23930	COG0789	Transcriptional regulator
C2I06_23940	COG1733	regulation of RNA biosynthetic process
C2I06_23955	COG0586	Pfam SNARE associated Golgi protein
C2I06_23970	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C2I06_23985	COG1063	alcohol dehydrogenase
C2I06_24000	COG2116	formate transmembrane transporter activity
C2I06_24015	COG3382	B3 4 domain protein
C2I06_24020	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C2I06_24035	COG0778	Nitroreductase
C2I06_24040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2I06_24045	COG2766	serine protein kinase
C2I06_24070	COG2832	Protein of unknown function (DUF454)
C2I06_24085	COG0667	Aldo Keto reductase
C2I06_24095	COG1737	Transcriptional regulator
C2I06_24100	COG2723	6-phospho-beta-galactosidase activity
C2I06_24105	COG1263	PTS System
C2I06_24105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I06_24105	COG2190	(PTS) system
C2I06_24110	COG0641	radical SAM
C2I06_24130	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2I06_24135	COG1917	Cupin 2, conserved barrel domain protein
C2I06_24135	COG4977	sequence-specific DNA binding
C2I06_24150	COG0500	methyltransferase
C2I06_24155	COG1733	regulation of RNA biosynthetic process
C2I06_24195	COG0583	DNA-binding transcription factor activity
C2I06_24205	COG0662	Cupin 2, conserved barrel domain protein
C2I06_24255	COG1733	regulation of RNA biosynthetic process
C2I06_24260	COG1028	Short-chain dehydrogenase reductase Sdr
C2I06_24285	COG2329	Antibiotic biosynthesis monooxygenase
C2I06_24290	COG2207	Transcriptional regulator
C2I06_24290	COG1917	Cupin 2, conserved barrel domain protein
C2I06_24295	COG0697	spore germination
C2I06_24300	COG2315	Protein conserved in bacteria
C2I06_24305	COG2207	Transcriptional regulator
C2I06_24310	COG2211	Major facilitator Superfamily
C2I06_24315	COG3250	beta-galactosidase activity
C2I06_24325	COG1312	Catalyzes the dehydration of D-mannonate
C2I06_24330	COG1028	Short-chain dehydrogenase reductase Sdr
C2I06_24335	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C2I06_24345	COG2197	response regulator
C2I06_24350	COG4585	Histidine kinase
C2I06_24355	COG3239	Fatty acid desaturase
C2I06_24365	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2I06_24375	COG1396	sequence-specific DNA binding
C2I06_24390	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2I06_24395	COG0745	RESPONSE REGULATOR receiver
C2I06_24395	COG3706	GGDEF domain
C2I06_24415	COG0745	RESPONSE REGULATOR receiver
C2I06_24420	COG5002	protein histidine kinase activity
C2I06_24425	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I06_24435	COG0306	phosphate transporter
C2I06_24440	COG1392	Phosphate transport regulator
C2I06_24445	COG1028	Short-chain dehydrogenase reductase Sdr
C2I06_24450	COG0656	L-ascorbic acid biosynthetic process
C2I06_24455	COG2261	transglycosylase associated protein
C2I06_24460	COG0564	pseudouridine synthase activity
C2I06_24470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2I06_24480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2I06_24480	COG3153	acetyltransferase
C2I06_24500	COG2252	PERMEase
C2I06_24515	COG0583	DNA-binding transcription factor activity
C2I06_24520	COG1309	transcriptional regulator
C2I06_24525	COG2076	Multidrug Resistance protein
C2I06_24555	COG2378	regulation of single-species biofilm formation
C2I06_24600	COG1694	Mazg nucleotide pyrophosphohydrolase
C2I06_24605	COG0789	Transcriptional regulator
C2I06_24605	COG4978	Transcriptional regulator
C2I06_24610	COG1811	Na channel or pump
C2I06_24615	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C2I06_24620	COG1131	(ABC) transporter
C2I06_24630	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I06_24635	COG0598	Magnesium transport protein CorA
C2I06_24640	COG0745	RESPONSE REGULATOR receiver
C2I06_24645	COG1253	flavin adenine dinucleotide binding
C2I06_24650	COG1253	flavin adenine dinucleotide binding
C2I06_24655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I06_24660	COG0840	transmembrane signaling receptor activity
C2I06_24660	COG5278	phosphoserine phosphatase activity
C2I06_24675	COG2814	Major facilitator Superfamily
C2I06_24680	COG1132	(ABC) transporter
C2I06_24685	COG1132	(ABC) transporter
C2I06_24690	COG2819	hydrolase of the alpha beta superfamily
C2I06_24695	COG2207	Transcriptional regulator
C2I06_24695	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2I06_24700	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2I06_24705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I06_24710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I06_24715	COG2819	hydrolase of the alpha beta superfamily
C2I06_24735	COG3842	ATPase activity
C2I06_24740	COG2508	Transcriptional regulator
C2I06_24745	COG0189	ligase activity
C2I06_24750	COG0189	ligase activity