locus-tag class description C2H98_00050 ENOG4105CBJ Metal-dependent enzyme C2H98_00060 ENOG4105DC7 peptidase M24 C2H98_00065 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) C2H98_00080 ENOG4105C2F Histidine kinase C2H98_00085 ENOG4105EQD regulatoR C2H98_00105 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component C2H98_00115 ENOG41066F8 ROK family C2H98_00120 ENOG4105CJQ hydrolase, family 31 C2H98_00125 ENOG4105CS2 ec 3.2.1.21 C2H98_00135 ENOG4105G6Z alkaline phosphatase C2H98_00155 ENOG4105CD2 stage iii sporulation protein aa C2H98_00160 ENOG4105KR5 Stage iii sporulation protein C2H98_00165 ENOG4108CQH stage III sporulation protein AC C2H98_00170 ENOG4105KQ4 Stage iii sporulation protein ad C2H98_00180 ENOG410644B Stage III sporulation protein af C2H98_00200 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C2H98_00205 ENOG4108ZSR alkaline shock protein C2H98_00210 ENOG4105M7K Involved in the transcription termination process (By similarity) C2H98_00220 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) C2H98_00225 ENOG4105CTB Polyprenyl synthetase C2H98_00230 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) C2H98_00235 ENOG4105DX0 Hemolysin A C2H98_00240 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) C2H98_00245 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) C2H98_00250 ENOG4105S1Z Stage IV sporulation protein B C2H98_00255 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase C2H98_00260 ENOG4107QQR Sporulation C2H98_00265 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C2H98_00280 ENOG4108NE4 C2H98_00320 ENOG4105VEQ Cold shock protein C2H98_00325 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C2H98_00330 ENOG4108JUB Transcriptional regulator C2H98_00335 ENOG4105CKM Branched-chain carboxylic acid kinase C2H98_00350 ENOG4105CPP Dehydrogenase, E1 component C2H98_00355 ENOG4105C7S Dehydrogenase C2H98_00360 ENOG4108Y6J UPF0403 protein C2H98_00365 ENOG4108HW3 (ABC) transporter C2H98_00370 ENOG4105E5Q amino acid AbC transporter C2H98_00375 ENOG4105CDA abc transporter atp-binding protein C2H98_00380 ENOG4108VZI ErfK ybiS ycfS ynhG family protein C2H98_00385 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) C2H98_00395 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C2H98_00400 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) C2H98_00405 ENOG4107RN3 metallophosphoesterase C2H98_00410 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase C2H98_00415 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) C2H98_00420 ENOG4105II7 pyrroline-5-carboxylate reductase C2H98_00430 ENOG4108IXY short-chain dehydrogenase reductase C2H98_00450 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) C2H98_00495 ENOG4108A65 Transcriptional regulator C2H98_00500 ENOG4107XZQ multidrug resistance protein C2H98_00510 ENOG4108X3M OsmC Ohr family protein C2H98_00540 ENOG41067QW Transcriptional regulator C2H98_00545 ENOG4108RVA ribokinase C2H98_00590 ENOG41073TP transcriptional regulator C2H98_00595 ENOG4105CXK mandelate racemase muconate lactonizing C2H98_00600 ENOG4105CPQ Dehydrogenase C2H98_00605 ENOG4105CHR reductase C2H98_00610 ENOG4105DJB Major Facilitator Superfamily C2H98_00645 ENOG4107TVP HD domain protein C2H98_00650 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) C2H98_00660 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C2H98_00680 ENOG4105CPC Aldo Keto reductase C2H98_00705 ENOG4105MZ9 stage II sporulation protein m C2H98_00710 ENOG4105I3K Ferric uptake regulator, Fur family C2H98_00720 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C2H98_00795 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) C2H98_00815 ENOG4105JVQ RNA Polymerase C2H98_00820 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) C2H98_00825 ENOG4105DZ1 carboxypeptidase C2H98_00830 ENOG41082AN stage II sporulation protein C2H98_00835 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) C2H98_00840 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C2H98_00855 ENOG4105G6R Stage v sporulation protein ae C2H98_00870 ENOG4105PTM secreted protein C2H98_00885 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) C2H98_00890 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) C2H98_00895 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C2H98_00900 ENOG4105DZ1 carboxypeptidase C2H98_00905 ENOG4108JIC nucleoside recognition domain protein C2H98_00915 ENOG4105FE9 pseudouridine synthase C2H98_00920 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C2H98_00925 ENOG4105BZU Histidine kinase C2H98_00945 ENOG4105DR5 peptidase C2H98_00950 ENOG4108SAX Membrane C2H98_00965 ENOG4105C9U ATP-dependent DNA helicase RecQ C2H98_00970 ENOG4105I7S Abortive infection protein C2H98_00985 ENOG4105WEF catalase C2H98_01000 ENOG4107RGJ metallophosphoesterase C2H98_01015 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase C2H98_01025 ENOG4105F0V Cell wall hydrolase C2H98_01030 ENOG4105MSI germination protein ypeb C2H98_01045 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) C2H98_01060 ENOG4105S2F C2H98_01065 ENOG41065D1 C2H98_01070 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) C2H98_01075 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase C2H98_01080 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) C2H98_01085 ENOG4105K70 DNA-binding protein C2H98_01090 ENOG4105XXQ heptaprenyl diphosphate synthase component I C2H98_01095 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) C2H98_01100 ENOG4105EAH synthase C2H98_01105 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) C2H98_01110 ENOG4105BZU Histidine kinase C2H98_01120 ENOG4105D49 3-dehydroquinate synthase C2H98_01125 ENOG4105KHN chorismate mutase C2H98_01130 ENOG4105CIH Imidazole acetol-phosphate transaminase C2H98_01140 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase C2H98_01150 ENOG41068YB TPR repeat-containing protein C2H98_01155 ENOG4108SXZ UPF0302 protein C2H98_01175 ENOG4105EU0 Major facilitator Superfamily C2H98_01185 ENOG4108JYZ YitT family C2H98_01190 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase C2H98_01195 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) C2H98_01200 ENOG4108Z5K methylglyoxal synthase C2H98_01205 ENOG4105FJR Lmbe family C2H98_01210 ENOG4105CPK Glycosyl transferase (Group 1 C2H98_01215 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate C2H98_01225 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) C2H98_01230 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) C2H98_01235 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) C2H98_01250 ENOG4105CHM Aminotransferase C2H98_01255 ENOG4105C5S asparaginyl-tRNA synthetase C2H98_01265 ENOG4105CSM endonuclease III C2H98_01275 ENOG4105BZ4 penicillin-binding protein C2H98_01310 ENOG4107Y70 Heat shock protein C2H98_01315 ENOG4108MXF Alpha Beta Hydrolase C2H98_01320 ENOG4108I5C dEAD DEAH box helicase C2H98_01325 ENOG4107X2U Inherit from COG: Exonuclease-like protein C2H98_01335 ENOG4106F55 Protein of unknown function (DUF1273) C2H98_01340 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) C2H98_01350 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) C2H98_01355 ENOG4105DVT helicase C2H98_01360 ENOG4105CTD carboxy-peptidase C2H98_01370 ENOG410890F Dynamin family C2H98_01375 ENOG4105KHC sulfurtransferase C2H98_01385 ENOG4105DVE abc transporter atp-binding protein C2H98_01415 ENOG41081VK Ribonuclease C2H98_01445 ENOG4108QEG Membrane C2H98_01470 ENOG4105C9U ATP-dependent DNA helicase RecQ C2H98_01475 ENOG4105KST dependent repressor C2H98_01490 ENOG4105CVG Homoserine O-transsuccinylase C2H98_01495 ENOG4105CKU formyltetrahydrofolate synthetase C2H98_01505 ENOG4108V06 Glutathione peroxidase C2H98_01530 ENOG4105C5H ABC transporter C2H98_01545 ENOG4107YX5 Pfam:DUF548 C2H98_01555 ENOG4106FN3 tellurium resistance protein C2H98_01560 ENOG4107TS3 membrane protein, TerC C2H98_01575 ENOG4105DAX Pfam:DUF2983 C2H98_01590 ENOG4108TTB tellurium resistance protein C2H98_01600 ENOG4108N0M stress protein C2H98_01605 ENOG4106FN3 tellurium resistance protein C2H98_01610 ENOG4106E8G C2H98_01615 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) C2H98_01620 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) C2H98_01625 ENOG4105FDP GntR family transcriptional regulator C2H98_01640 ENOG4108UZY PTS System C2H98_01645 ENOG4105ETZ PTS System C2H98_01650 ENOG4105F3R pts system mannose fructose sorbose family iid C2H98_01655 ENOG4108UT2 hemolysin iii C2H98_01660 ENOG4105C7B Threonine dehydratase C2H98_01665 ENOG4108RCR degv family C2H98_01670 ENOG4105BZU Histidine kinase C2H98_01675 ENOG41090WU lipolytic protein G-D-S-L family C2H98_01695 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) C2H98_01700 ENOG4105E0X reductase C2H98_01710 ENOG4105VSD UPF0346 protein C2H98_01730 ENOG4108VXD carboxy-peptidase C2H98_01740 ENOG4105CKI cobalamin synthesis protein C2H98_01755 ENOG4105K4I Scp-like extracellular C2H98_01775 ENOG4107QMU Mate efflux family protein C2H98_01780 ENOG41082YX Transcriptional regulator, arsr family C2H98_01785 ENOG4107R5R arsenical pump membrane protein C2H98_01815 ENOG4105D58 Diguanylate phosphodiesterase C2H98_01820 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) C2H98_01830 ENOG4105DQE DNA ligase C2H98_01835 ENOG4105FDF Could be involved in DNA repair (By similarity) C2H98_01840 ENOG410841Q phosphoesterase PA-phosphatase related protein C2H98_01845 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator C2H98_01860 ENOG4105C6V Glycerol-3-phosphate dehydrogenase C2H98_01865 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) C2H98_01870 ENOG4105VEQ Cold shock protein C2H98_01875 ENOG4105C1J atp-dependent rna helicase C2H98_01880 ENOG4105VEQ Cold shock protein C2H98_01900 ENOG41067MG lrgb family C2H98_01905 ENOG4105VAW lrga family C2H98_01910 ENOG4105CMU LysR family (Transcriptional regulator C2H98_01930 ENOG4108ZJ4 polysaccharide deacetylase C2H98_01950 ENOG4105KWG Pfam:DUF1696 C2H98_01980 ENOG41068WN C2H98_01985 ENOG4105CVJ phosphoglycerate mutase C2H98_01995 ENOG4105D9U N-acetyltransferase C2H98_02010 ENOG41068VA C2H98_02015 ENOG4107T5V SNARE associated Golgi C2H98_02030 ENOG41090T1 Membrane C2H98_02035 ENOG4105E0Y RtcB Protein C2H98_02075 ENOG4105BZG amino acid carrier protein C2H98_02080 ENOG41086D8 Transcriptional regulator C2H98_02090 ENOG4105JAB phenazine biosynthesis protein, phzf family C2H98_02110 ENOG4106BRA Membrane C2H98_02140 ENOG4105DDN Pentapeptide repeat-containing protein C2H98_02155 ENOG4105JVQ RNA Polymerase C2H98_02185 ENOG4108ZMX Domain of unknown function (DU1801) C2H98_02190 ENOG4105CZ9 Domain of unknown function (DU1801) C2H98_02205 ENOG4105VMP Transcriptional regulator C2H98_02210 ENOG4105NX3 Membrane C2H98_02495 ENOG4106YAD MORN repeat variant C2H98_02540 ENOG4105CKI cobalamin synthesis protein C2H98_02545 ENOG4105WDJ 50S ribosomal protein L33 C2H98_02550 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) C2H98_02580 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate C2H98_02615 ENOG4107S1Q Phosphatase C2H98_02625 ENOG4105C8Q Methyl-accepting chemotaxis C2H98_02630 ENOG4105CKI cobalamin synthesis protein C2H98_02635 ENOG4108PJD permease C2H98_02650 ENOG4105DWF phosphomethylpyrimidine kinase C2H98_02675 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) C2H98_02690 ENOG4105E98 transcriptional regulator DeoR family C2H98_02695 ENOG4105DE4 1-phosphofructokinase C2H98_02700 ENOG4105DM4 PTS System C2H98_02710 ENOG4108RPX mosc domain containing protein C2H98_02715 ENOG4105CRQ synthase (Component I) C2H98_02720 ENOG4105DDQ anthranilate synthase C2H98_02725 ENOG4108I0Q anthranilate phosphoribosyltransferase C2H98_02755 ENOG4105BZ1 (ABC) transporter C2H98_02770 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) C2H98_02775 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) C2H98_02810 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) C2H98_02820 ENOG4105DR4 Methyltransferase C2H98_02825 ENOG4105U0R haloacid dehalogenase-like hydrolase C2H98_02830 ENOG4105EW9 transcriptional regulator AsnC family C2H98_02835 ENOG4107AYK membrAne C2H98_02850 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) C2H98_02855 ENOG4105SZ6 Thioredoxin C2H98_02865 ENOG4108X4Q Hydrolase C2H98_02875 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic C2H98_02880 ENOG4105DEN Luciferase family C2H98_02895 ENOG4108T5E Copper resistance protein C2H98_02900 ENOG4105VKD bioY protein C2H98_02925 ENOG4105CZM Major Facilitator C2H98_02930 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin C2H98_02935 ENOG4105DG6 mannose-6-phosphate isomerase C2H98_02950 ENOG4105E98 transcriptional regulator DeoR family C2H98_02955 ENOG410667J hydrolase C2H98_02960 ENOG4105F6E Acyl-transferase C2H98_02965 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) C2H98_02970 ENOG4108ZRV stage ii sporulation protein p C2H98_02985 ENOG41082JN Transcriptional regulator C2H98_02995 ENOG4105N67 Proton-coupled thiamine transporter YuaJ C2H98_03015 ENOG4105C8Q Methyl-accepting chemotaxis C2H98_03020 ENOG4105K4P CoA-binding domain protein C2H98_03025 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C2H98_03055 ENOG4105CVJ phosphoglycerate mutase C2H98_03075 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase C2H98_03110 ENOG4105E98 transcriptional regulator DeoR family C2H98_03115 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) C2H98_03120 ENOG4105EJ9 Membrane C2H98_03125 ENOG4105DUM transcriptional regulator, lysR family C2H98_03135 ENOG4105C5Y PTS System C2H98_03145 ENOG4105ETE Transcriptional regulator (LacI family C2H98_03150 ENOG4105C3M thioredoxin reductase C2H98_03165 ENOG4108PJD permease C2H98_03210 ENOG4105BZU Histidine kinase C2H98_03225 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) C2H98_03230 ENOG4105CH6 catalase C2H98_03235 ENOG4105CD5 CoA-binding domain protein C2H98_03255 ENOG4105D5Q Arginine ornithine antiporter C2H98_03265 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) C2H98_03280 ENOG4105C8Q Methyl-accepting chemotaxis C2H98_03290 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) C2H98_03295 ENOG4105CSV Glutaminase C2H98_03300 ENOG4105BZU Histidine kinase C2H98_03310 ENOG4105DY9 regulatoR C2H98_03315 ENOG4108HRK Histidine kinase C2H98_03320 ENOG4108B1Q Ribonuclease C2H98_03330 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family C2H98_03340 ENOG4105DYS nad(p)h dehydrogenase (quinone) C2H98_03345 ENOG4105KVH Transcriptional regulator C2H98_03375 ENOG4105BZU Histidine kinase C2H98_03385 ENOG4105C1J atp-dependent rna helicase C2H98_03395 ENOG4105J7I hydrolase C2H98_03405 ENOG4105CGK Exodeoxyribonuclease III C2H98_03415 ENOG4108R6K riboflavin synthase, subunit alpha C2H98_03420 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) C2H98_03425 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) C2H98_03440 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C2H98_03455 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family C2H98_03465 ENOG4105C3F Signal peptidase i C2H98_03480 ENOG4108XRC Protein of unknown function (DUF458) C2H98_03485 ENOG4107TS3 membrane protein, TerC C2H98_03490 ENOG4107EXU Short-chain dehydrogenase reductase Sdr C2H98_03495 ENOG4107ZE5 PPIases accelerate the folding of proteins C2H98_03500 ENOG4107XH4 PPIases accelerate the folding of proteins (By similarity) C2H98_03515 ENOG4105BZ8 glutamate synthase C2H98_03520 ENOG4105CBC glutamate synthase C2H98_03525 ENOG4105C5Q Transcriptional regulator C2H98_03530 ENOG4105DPN Oligoendopeptidase f C2H98_03540 ENOG410667J hydrolase C2H98_03550 ENOG4105CM2 brancheD-chain amino acid aminotransferase C2H98_03565 ENOG4105FCD Major Facilitator C2H98_03570 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR C2H98_03575 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) C2H98_03585 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) C2H98_03590 ENOG4107YV9 domain protein C2H98_03595 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding C2H98_03610 ENOG4105XRQ Xanthine dehydrogenase accessory factor C2H98_03625 ENOG41069ER domain protein C2H98_03630 ENOG4105BZU Histidine kinase C2H98_03640 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) C2H98_03645 ENOG4105C9U ATP-dependent DNA helicase RecQ C2H98_03670 ENOG4108QTI )-transporter C2H98_03675 ENOG4105C5H ABC transporter C2H98_03680 ENOG4105DZ1 carboxypeptidase C2H98_03695 ENOG4105F1A Pyruvate formate-lyase C2H98_03705 ENOG4105DAP Nicotinate phosphoribosyltransferase C2H98_03730 ENOG4105WMR Protein CrcB homolog C2H98_03745 ENOG4105C7S Dehydrogenase C2H98_03755 ENOG4105GR3 Histidine kinase C2H98_03760 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C2H98_03765 ENOG41069DP small acid-soluble spore protein C2H98_03770 ENOG4105C28 cystathionine C2H98_03775 ENOG4105C28 cystathionine C2H98_03805 ENOG4105C0R drug resistance transporter emrb qaca subfamily C2H98_03825 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase C2H98_03830 ENOG4105FDT acyl-CoA dehydrogenase C2H98_03845 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) C2H98_03850 ENOG4105BZU Histidine kinase C2H98_03855 ENOG4105PNM synthesis protein C2H98_03860 ENOG4105W8X HesB YadR YfhF-family protein C2H98_03865 ENOG4105MI2 C2H98_03880 ENOG4106F1P AAA ATPase, central domain protein C2H98_03885 ENOG41075ZD Small, acid-soluble spore protein N C2H98_03895 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C2H98_03900 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase C2H98_03910 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C2H98_03930 ENOG4108I0Z Aconitate hydratase C2H98_03940 ENOG4107DZX Small, acid-soluble spore protein P C2H98_03960 ENOG4105E2A Dehydrogenase C2H98_03965 ENOG4105PGS Spore coat protein C2H98_03990 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C2H98_03995 ENOG4105KD7 acetyltransferase C2H98_04020 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) C2H98_04025 ENOG4105EEM helicase C2H98_04035 ENOG4105DER m42 family C2H98_04045 ENOG4105EYH Exonuclease C2H98_04050 ENOG4107RFY SbcCD D subunit C2H98_04055 ENOG4105VEQ Cold shock protein C2H98_04090 ENOG4107YTP response regulator receiver protein C2H98_04095 ENOG4107QIV Cytochrome c biogenesis protein C2H98_04105 ENOG4105BZ1 (ABC) transporter C2H98_04110 ENOG4105BZ1 (ABC) transporter C2H98_04125 ENOG4105CV1 Transketolase (EC 2.2.1.1) C2H98_04130 ENOG4105VPS UPF0291 protein C2H98_04135 ENOG4108SVB resolvase C2H98_04145 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) C2H98_04165 ENOG4108XHQ (2Fe-2S)-binding domain protein C2H98_04175 ENOG4105C7W Xanthine dehydrogenase C2H98_04180 ENOG4108YYS metal-dependent hydrolase (By similarity) C2H98_04190 ENOG4108URH decarboxylase C2H98_04235 ENOG4105KNA -acetyltransferase C2H98_04250 ENOG4105C5F glutamine synthetase C2H98_04255 ENOG4105KV4 Transcriptional regulator C2H98_04260 ENOG4105CXI aluminum resistance protein C2H98_04265 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) C2H98_04270 ENOG4106F1P AAA ATPase, central domain protein C2H98_04280 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) C2H98_04290 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) C2H98_04295 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase C2H98_04300 ENOG4108IYU L-aspartate oxidase C2H98_04320 ENOG410870W N-acetyltransferase C2H98_04405 ENOG4108Z6X (sortase) family C2H98_04425 ENOG4108ZRV stage ii sporulation protein p C2H98_04430 ENOG4105BZU Histidine kinase C2H98_04475 ENOG4105EGI Transcriptional regulator C2H98_04510 ENOG4108RZE Tetr family transcriptional regulator C2H98_04515 ENOG41080TC multidrug resistance protein C2H98_04570 ENOG4105GPN Uncharacterized conserved protein (DUF2294) C2H98_04585 ENOG4108TWJ NADH dehydrogenase subunit 5 C2H98_04600 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) C2H98_04605 ENOG4105VMP Transcriptional regulator C2H98_04630 ENOG4108YX9 iron--sulfur cluster insertion protein erpA C2H98_04640 ENOG4107QKR Dehydrogenase C2H98_04650 ENOG4107RUY (E1 component), alpha subunit C2H98_04655 ENOG4108JUA Transcriptional regulator C2H98_04685 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) C2H98_04730 ENOG41061CK Antibiotic biosynthesis monooxygenase C2H98_04735 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) C2H98_04755 ENOG4105KTB nuclear export factor GLE1 C2H98_04760 ENOG4105C75 arginyL-tRNA synthetase C2H98_04770 ENOG41086D8 Transcriptional regulator C2H98_04835 ENOG4105PAD Hydrolase C2H98_04850 ENOG4105BZU Histidine kinase C2H98_04870 ENOG4105EQ0 Major Facilitator superfamily C2H98_04875 ENOG4108IND Tetr family transcriptional regulator C2H98_04880 ENOG4105EWI Short-chain dehydrogenase reductase Sdr C2H98_04890 ENOG4108RWP Major Facilitator Superfamily protein C2H98_04895 ENOG4105WAB arsR family transcriptional regulator C2H98_04925 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C2H98_04940 ENOG4108J2P Alpha beta hydrolase fold C2H98_04945 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) C2H98_04965 ENOG4108XET gCN5-related N-acetyltransferase C2H98_05005 ENOG4108UYN gCN5-related N-acetyltransferase C2H98_05015 ENOG4105CRK lysyL-tRNA synthetase C2H98_05070 ENOG4107TXC Transcriptional regulator C2H98_05085 ENOG4105CDY transcriptional regulatory protein C2H98_05090 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) C2H98_05095 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C2H98_05140 ENOG41060YP C2H98_05175 ENOG41068WN C2H98_05180 ENOG41086D8 Transcriptional regulator C2H98_05190 ENOG4105CHR reductase C2H98_05200 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold C2H98_05230 ENOG4105EP8 Glycosyl Hydrolase Family 88 C2H98_05235 ENOG4108EQA pts system C2H98_05240 ENOG4105F3R pts system mannose fructose sorbose family iid C2H98_05245 ENOG4105ETZ PTS System C2H98_05255 ENOG4105FDP GntR family transcriptional regulator C2H98_05310 ENOG4105NA0 Transcriptional regulator C2H98_05315 ENOG4107RVG penicillin-binding protein C2H98_05320 ENOG4107RF6 penicillin-binding protein C2H98_05330 ENOG4105CHR reductase C2H98_05335 ENOG4105CVK Glutamate decarboxylase C2H98_05345 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) C2H98_05365 ENOG4108ZHR arsR family transcriptional regulator C2H98_05375 ENOG4105CHR reductase C2H98_05395 ENOG4105C0X amino acid C2H98_05430 ENOG4108VKI Cell wall hydrolase C2H98_05465 ENOG4105FTV AraC Family Transcriptional Regulator C2H98_05480 ENOG410645S MarR family Transcriptional regulator C2H98_05485 ENOG4105DCM major facilitator superfamily C2H98_05490 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) C2H98_05500 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C2H98_05505 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C2H98_05520 ENOG4107T5V SNARE associated Golgi C2H98_05525 ENOG4105EU9 C2H98_05560 ENOG4105VCP PTS System C2H98_05565 ENOG4105EMD TRANSCRIPTIONal C2H98_05580 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) C2H98_05585 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) C2H98_05590 ENOG4105X3H Excalibur domain protein C2H98_05620 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) C2H98_05625 ENOG4108IGT Dipeptidase C2H98_05630 ENOG4105MCT stage V sporulation protein S C2H98_05635 ENOG4105D48 metallophosphoesterase C2H98_05640 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) C2H98_05645 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) C2H98_05650 ENOG4105CEV competence damage-inducible protein C2H98_05655 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase C2H98_05670 ENOG4105XZV Protein of unknown function (DUF3243) C2H98_05675 ENOG4108RKS Short-chain dehydrogenase reductase Sdr C2H98_05705 ENOG4105UIB (ABC) transporter C2H98_05710 ENOG4108JQ9 ABC transporter C2H98_05715 ENOG4105DIH basic membrane C2H98_05720 ENOG4105FDP GntR family transcriptional regulator C2H98_05725 ENOG4105CNU cell division protein FtsK C2H98_05740 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit C2H98_05755 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C2H98_05765 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) C2H98_05770 ENOG4108S0H Dipicolinic acid synthetase, b subunit C2H98_05775 ENOG4105E35 Dipicolinate synthase subunit A C2H98_05780 ENOG4105C1V Peptidase, M16 C2H98_05790 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) C2H98_05795 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) C2H98_05800 ENOG4105DTN riboflavin biosynthesis protein ribF C2H98_05805 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) C2H98_05815 ENOG4105W7A Protein of unknown function (DUF503) C2H98_05820 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) C2H98_05825 ENOG4105VHM ribosomal protein C2H98_05830 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination C2H98_05835 ENOG4105CHV Transcription elongation factor NusA C2H98_05840 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) C2H98_05845 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) C2H98_05850 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) C2H98_05855 ENOG4105DZP Membrane-associated zinc metalloprotease C2H98_05860 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) C2H98_05865 ENOG4105KNE Phosphatidate cytidylyltransferase C2H98_05870 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) C2H98_05875 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) C2H98_05890 ENOG4105CE9 30S ribosomal protein S2 C2H98_05905 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C2H98_05910 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) C2H98_05920 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis C2H98_05925 ENOG4105CBS Chea signal transduction histidine kinase C2H98_05930 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) C2H98_05940 ENOG4105FZW flagellar biosynthesis regulator FlhF C2H98_05945 ENOG4105D7B Flagellar biosynthesis protein flha C2H98_05950 ENOG4105D00 flagellar biosynthetic protein flhB C2H98_05955 ENOG4105D19 Role in flagellar biosynthesis (By similarity) C2H98_05960 ENOG4105VS8 Flagellar biosynthetic protein fliq C2H98_05965 ENOG4105CN7 Flagellar biosynthetic protein FliP C2H98_05975 ENOG4107YTP response regulator receiver protein C2H98_05980 ENOG4105DD5 Flagellar motor switch protein C2H98_05985 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C2H98_05995 ENOG41068WV flagellar FlbD family protein C2H98_06000 ENOG4108JQA flagellar C2H98_06010 ENOG410822I Flagellar hook capping protein C2H98_06025 ENOG4106YF4 Flagellar biosynthesis chaperone C2H98_06040 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C2H98_06045 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) C2H98_06050 ENOG4105VQ0 flagellar hook-basal body complex protein fliE C2H98_06055 ENOG4108ZC9 flagellar basal-body rod protein flgc C2H98_06060 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) C2H98_06065 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) C2H98_06070 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) C2H98_06075 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) C2H98_06080 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C2H98_06085 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) C2H98_06090 ENOG4105C79 DNA protecting protein DprA C2H98_06095 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha C2H98_06100 ENOG4105CMV Succinyl-CoA synthetase subunit beta C2H98_06105 ENOG4105D00 flagellar biosynthetic protein flhB C2H98_06120 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) C2H98_06125 ENOG4105C3F Signal peptidase i C2H98_06135 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) C2H98_06140 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) C2H98_06150 ENOG4105VB6 UPF0109 protein C2H98_06155 ENOG4105K5M 30s ribosomal protein S16 C2H98_06165 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) C2H98_06185 ENOG4105C7R Atpase associated with various cellular activities aaa_3 C2H98_06200 ENOG4105CJ1 ABC, transporter C2H98_06215 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) C2H98_06220 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) C2H98_06225 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) C2H98_06230 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) C2H98_06235 ENOG4105CHR reductase C2H98_06240 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase C2H98_06245 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) C2H98_06250 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) C2H98_06255 ENOG4105CB5 ATP-dependent DNA helicase recG C2H98_06260 ENOG4105EJQ L-serine dehydratase C2H98_06270 ENOG4105DP4 dak2 domain fusion protein ylov C2H98_06275 ENOG4108ZAA Alkaline-shock protein C2H98_06280 ENOG4105VB9 50S ribosomal protein l28 C2H98_06290 ENOG4105FJ0 thiamine C2H98_06295 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) C2H98_06300 ENOG4105D9P serine threonine protein kinase C2H98_06305 ENOG4108ZF3 Phosphatase C2H98_06310 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs C2H98_06315 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B C2H98_06320 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) C2H98_06330 ENOG4105CNT hydrolase family 2 C2H98_06345 ENOG4105EG2 ABC transporter, permease C2H98_06365 ENOG4105C25 Primosomal protein n' C2H98_06370 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase C2H98_06380 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) C2H98_06385 ENOG4105KC4 UPF0296 protein C2H98_06390 ENOG4105DSJ YicC domain protein C2H98_06400 ENOG4105F23 Fibronectin-binding protein C2H98_06415 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) C2H98_06425 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain C2H98_06435 ENOG4105CD3 dihydroorotase C2H98_06440 ENOG4105CXT aspartate transcarbamylase C2H98_06450 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) C2H98_06455 ENOG4105C34 Pseudouridine synthase C2H98_06460 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) C2H98_06465 ENOG4105SCY DNAK suppressor C2H98_06470 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) C2H98_06480 ENOG4105DBK s4 domain protein C2H98_06485 ENOG41067XK integral membrane protein C2H98_06490 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) C2H98_06495 ENOG4105DFA alanine racemase domain protein C2H98_06500 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase C2H98_06510 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C2H98_06515 ENOG4105FFI sigma-e processing peptidase spoiiga C2H98_06520 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) C2H98_06525 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) C2H98_06530 ENOG4105K67 small basic protein C2H98_06540 ENOG4108R2U division initiation protein C2H98_06545 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) C2H98_06550 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) C2H98_06555 ENOG4105CNI cell division protein FtsW C2H98_06560 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) C2H98_06565 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) C2H98_06575 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) C2H98_06580 ENOG4105CJN penicillin-binding protein C2H98_06590 ENOG4105CJN penicillin-binding protein C2H98_06605 ENOG4108V6E Cell division protein mraZ C2H98_06610 ENOG41074B2 UPF0747 protein C2H98_06630 ENOG4105EWC Purine nucleoside phosphorylase C2H98_06640 ENOG4105KNH Nucleic acid-binding protein C2H98_06645 ENOG4105CDE UPF0348 protein C2H98_06650 ENOG4105D78 K07001 NTE family protein C2H98_06655 ENOG4105H20 Sporulation integral membrane protein YlbJ C2H98_06660 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) C2H98_06665 ENOG4106H78 methyltransferase C2H98_06695 ENOG4106UY4 Inherit from COG: Scp-like extracellular C2H98_06705 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) C2H98_06710 ENOG4105CNI cell division protein FtsW C2H98_06725 ENOG4108IAB Phoh family C2H98_06750 ENOG4105CI3 gtp-binding protein typa C2H98_06760 ENOG4105ECY inositol monophosphatase C2H98_06770 ENOG4108WQ8 UPF0637 protein C2H98_06780 ENOG4105CXN decarboxylase C2H98_06800 ENOG4105C7S Dehydrogenase C2H98_06805 ENOG4105CPP Dehydrogenase, E1 component C2H98_06830 ENOG4105CN5 Metallo-Beta-Lactamase C2H98_06835 ENOG4107ZYR domain protein C2H98_06840 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C2H98_06845 ENOG4105D8X mechanosensitive ion channel C2H98_06850 ENOG4105CH2 amidohydrolase C2H98_06855 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) C2H98_06870 ENOG4107IN1 Protein of unknown function (DUF1797) C2H98_06885 ENOG4105EPM Diguanylate phosphodiesterase C2H98_06895 ENOG4105BZU Histidine kinase C2H98_06900 ENOG4105UIN C2H98_06910 ENOG4107R88 Chemotaxis protein (CheV) C2H98_06930 ENOG4105CHM Aminotransferase C2H98_06935 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C2H98_06940 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic C2H98_06945 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) C2H98_06950 ENOG4105KRI phosphocarrier protein (HPr C2H98_06980 ENOG4108K88 Membrane C2H98_06995 ENOG41090MY MarR family Transcriptional regulator C2H98_07000 ENOG4105BZU Histidine kinase C2H98_07015 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase C2H98_07025 ENOG4105BZU Histidine kinase C2H98_07030 ENOG4108TGC Acyltransferase C2H98_07040 ENOG410681C small acid-soluble spore protein C2H98_07045 ENOG4107TS3 membrane protein, TerC C2H98_07055 ENOG4105CDA abc transporter atp-binding protein C2H98_07060 ENOG4105DRP amino acid AbC transporter C2H98_07065 ENOG4105EZ7 amino acid ABC transporter C2H98_07070 ENOG4107QXX ABC transporter C2H98_07075 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) C2H98_07080 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) C2H98_07095 ENOG4105TRT Transcriptional regulator C2H98_07100 ENOG4108IJ7 Glycine betaine C2H98_07105 ENOG4107SQ8 Glycine betaine C2H98_07115 ENOG4105DZ6 Band 7 protein C2H98_07130 ENOG4108X4Q Hydrolase C2H98_07135 ENOG4105DKW ABC transporter C2H98_07140 ENOG4105KRI phosphocarrier protein (HPr C2H98_07150 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic C2H98_07160 ENOG4105D5T phosphonate abc transporter C2H98_07185 ENOG4105DIK (ABC) transporter C2H98_07190 ENOG4105Z8B NlpC/P60 family C2H98_07195 ENOG4107VFR oxidoreductase C2H98_07205 ENOG4105HDK L-asparaginase C2H98_07215 ENOG4107Y03 Nitroreductase C2H98_07220 ENOG4108Q5U germination protein, ger(x)c family C2H98_07235 ENOG4108HGU Histidine kinase C2H98_07250 ENOG4105C0R drug resistance transporter emrb qaca subfamily C2H98_07260 ENOG4105F04 LysR family Transcriptional regulator C2H98_07275 ENOG4105CNI cell division protein FtsW C2H98_07285 ENOG4105EMN RNA polymerase sigma factor C2H98_07300 ENOG4105DSE periplasmic solute binding protein C2H98_07305 ENOG4105CK5 oxidoreductase C2H98_07310 ENOG4107QP6 Xylose isomerase domain protein TIM barrel C2H98_07330 ENOG4105E35 Dipicolinate synthase subunit A C2H98_07355 ENOG4107FCW Abortive infection protein C2H98_07380 ENOG4105EP8 Glycosyl Hydrolase Family 88 C2H98_07385 ENOG4107VQW regulatoR C2H98_07390 ENOG4105C2F Histidine kinase C2H98_07400 ENOG4105MU9 integral membrane protein C2H98_07405 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) C2H98_07415 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component C2H98_07420 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component C2H98_07425 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) C2H98_07430 ENOG4105CG3 alpha amylase, catalytic region C2H98_07435 ENOG4105ETE Transcriptional regulator (LacI family C2H98_07450 ENOG4105JVQ RNA Polymerase C2H98_07455 ENOG4105C26 Dehydrogenase C2H98_07470 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) C2H98_07480 ENOG4105BZU Histidine kinase C2H98_07515 ENOG4108IUW ABC transporter C2H98_07520 ENOG4105C85 amino acid C2H98_07525 ENOG4105C5T Phosphoribosyl pyrophosphate synthase C2H98_07535 ENOG4108JQ1 Dehydrogenase C2H98_07540 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) C2H98_07545 ENOG4105DAP Nicotinate phosphoribosyltransferase C2H98_07560 ENOG4105C94 Transporter C2H98_07570 ENOG4106R3P AraC family transcriptional regulator C2H98_07575 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) C2H98_07580 ENOG4107S2N Type III effector Hrp-dependent C2H98_07585 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) C2H98_07595 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) C2H98_07600 ENOG4105MU9 integral membrane protein C2H98_07605 ENOG4106Z5D Glycoside Hydrolase Family 43 C2H98_07610 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component C2H98_07625 ENOG4107V0Z fmn reductase C2H98_07650 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C2H98_07655 ENOG4107R6U sodium dicarboxylate symporter C2H98_07660 ENOG4105EUJ GTP cyclohydrolase i C2H98_07665 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) C2H98_07670 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase C2H98_07675 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) C2H98_07680 ENOG4108TYN CAAX amino terminal protease family protein C2H98_07700 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease C2H98_07705 ENOG4105G9B Transcriptional regulator C2H98_07715 ENOG4105CHR reductase C2H98_07725 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C2H98_07735 ENOG4108RQ5 Beta-lactamase domain-containing protein C2H98_07740 ENOG4105CTB Polyprenyl synthetase C2H98_07755 ENOG4107VXM glycerophosphoryl diester phosphodiesterase C2H98_07760 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C2H98_07780 ENOG4108IJ9 (ABC) transporter C2H98_07790 ENOG4108UQV Membrane C2H98_07800 ENOG41090KR LysR family transcriptional Regulator C2H98_07810 ENOG4105DSG hydrolase family 43 C2H98_07820 ENOG4105C01 Dihydroxy-acid dehydratase C2H98_07825 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C2H98_07830 ENOG4107HP6 Transcriptional regulator C2H98_07840 ENOG4105F0V Cell wall hydrolase C2H98_07845 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C2H98_07850 ENOG4105C4C beta-galactosidase C2H98_07855 ENOG4105DRS transport system, permease C2H98_07870 ENOG4105FTV AraC Family Transcriptional Regulator C2H98_07880 ENOG4108HQR Glycine betaine C2H98_07890 ENOG4105G0J serine threonine protein kinase C2H98_07895 ENOG4105F0V Cell wall hydrolase C2H98_07900 ENOG4107S8A protein TIM barrel C2H98_07920 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) C2H98_07930 ENOG4105DRS transport system, permease C2H98_07940 ENOG4105ECQ AraC Family Transcriptional Regulator C2H98_07945 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia C2H98_07955 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C2H98_07960 ENOG4105C2X Arabinose 5-phosphate isomerase C2H98_07990 ENOG4105WYW fructose-bisphosphate aldolase C2H98_08000 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) C2H98_08005 ENOG4105CKI cobalamin synthesis protein C2H98_08030 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) C2H98_08035 ENOG4105DCM major facilitator superfamily C2H98_08040 ENOG4105EA8 2-Nitropropane dioxygenase C2H98_08045 ENOG4108JUA Transcriptional regulator C2H98_08050 ENOG4107V9H nitrite transporter C2H98_08055 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein C2H98_08060 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C2H98_08065 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit C2H98_08070 ENOG4108IFG nitrite reductase, (NAD(P)H) C2H98_08080 ENOG4105CS2 ec 3.2.1.21 C2H98_08095 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) C2H98_08100 ENOG4105DJB Major Facilitator Superfamily C2H98_08105 ENOG4107R37 Glutamate dehydrogenase C2H98_08110 ENOG4105C5Q Transcriptional regulator C2H98_08115 ENOG4105C2F Histidine kinase C2H98_08120 ENOG4105EQD regulatoR C2H98_08125 ENOG4105XN3 extracellular solute-binding protein family 1 C2H98_08130 ENOG4105EDQ levansucrase EC 2.4.1.10 C2H98_08135 ENOG4108HKT sucrose-6-phosphate hydrolase C2H98_08140 ENOG4108HKT sucrose-6-phosphate hydrolase C2H98_08145 ENOG4105D7K pfkb domain protein C2H98_08150 ENOG4108HKT sucrose-6-phosphate hydrolase C2H98_08160 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component C2H98_08170 ENOG4105ETE Transcriptional regulator (LacI family C2H98_08180 ENOG4105GVF (ABC) transporter C2H98_08185 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component C2H98_08190 ENOG4105E2Y ABC, transporter C2H98_08200 ENOG4107RCC Major Facilitator Superfamily C2H98_08240 ENOG4105C2F Histidine kinase C2H98_08245 ENOG4108NEV two component transcriptional regulator, LytTR family C2H98_08250 ENOG4108WS4 fmn reductase C2H98_08255 ENOG4106YBV Methyl-accepting chemotaxis C2H98_08260 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C2H98_08290 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C2H98_08335 ENOG4105WEF catalase C2H98_08370 ENOG41085GJ domain protein C2H98_08375 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase C2H98_08380 ENOG4105XTG Pfam:DUF156 C2H98_08385 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase C2H98_08400 ENOG4108IUM Glycogen debranching enzyme C2H98_08405 ENOG4105CVA phosphate C2H98_08410 ENOG4108IG5 Transcriptional regulator C2H98_08420 ENOG4107TUM Amidinotransferase C2H98_08430 ENOG410756H nucleotidyltransferase C2H98_08435 ENOG41076HS cation diffusion facilitator family transporter C2H98_08440 ENOG4107S6X Glycosyl transferase, family 2 C2H98_08460 ENOG4105FAW cDP-glucose 4,6-dehydratase C2H98_08475 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase C2H98_08485 ENOG4105CG3 alpha amylase, catalytic region C2H98_08500 ENOG4105E98 transcriptional regulator DeoR family C2H98_08505 ENOG4108HWW ABC transporter C2H98_08525 ENOG4105C2F Histidine kinase C2H98_08535 ENOG4105DKG l-rhamnose isomerase C2H98_08540 ENOG4105DET Rhamnulokinase C2H98_08545 ENOG4107XVH Transcriptional regulator C2H98_08570 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) C2H98_08580 ENOG4105DJV ribulose-phosphate 3-epimerase C2H98_08595 ENOG4105DUX Transporter C2H98_08605 ENOG4105E7W lamb ycsf family protein C2H98_08610 ENOG4105FDP GntR family transcriptional regulator C2H98_08615 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) C2H98_08620 ENOG4105CE4 GlcNAc 6-P deacetylase C2H98_08630 ENOG4105K64 Glycosyl transferase, family 2 C2H98_08635 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase C2H98_08640 ENOG4105CMR udp-glucose 4-epimerase C2H98_08645 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) C2H98_08660 ENOG4105CMG Carbohydrate kinase C2H98_08675 ENOG4106KNT transcriptional regulator C2H98_08690 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) C2H98_08695 ENOG4105C6Z Gluconate C2H98_08700 ENOG4108ZJ4 polysaccharide deacetylase C2H98_08715 ENOG4108UZX fmn reductase C2H98_08725 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) C2H98_08730 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase C2H98_08740 ENOG4108ZMI UPF0477 protein C2H98_08750 ENOG4105H67 Protein of unknown function (DUF421) C2H98_08760 ENOG4105ENA helicase C2H98_08780 ENOG4105CZ3 stage V sporulation protein ad C2H98_08785 ENOG41090VF Stage v sporulation protein ac C2H98_08810 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH C2H98_08820 ENOG4105CJW magnesium transporter C2H98_08825 ENOG4107S1Q Phosphatase C2H98_08830 ENOG4105EMS pseudouridine synthase C2H98_08835 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) C2H98_08850 ENOG4105MIX Adenylate cyclase C2H98_08855 ENOG4105E4C Lytic transglycosylase catalytic C2H98_08860 ENOG4108Z18 K06886 hemoglobin C2H98_08865 ENOG4105T58 Dithiol-disulfide isomerase C2H98_08870 ENOG4105DPN Oligoendopeptidase f C2H98_08880 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) C2H98_08885 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis C2H98_08890 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) C2H98_08905 ENOG4108JQ7 (ABC) transporter C2H98_08915 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C2H98_08920 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C2H98_08925 ENOG4108J59 Extracellular solute-binding protein, family 5 C2H98_08930 ENOG4105C31 Tryptophanyl-tRNA synthetase C2H98_08935 ENOG4108KU1 UPF0736 protein C2H98_08945 ENOG4105G5W regulator Fur family C2H98_08950 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) C2H98_08955 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) C2H98_08965 ENOG4107RMD Basic membrane lipoprotein C2H98_08985 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit C2H98_08995 ENOG4105DBV ornithine carbamoyltransferase C2H98_09015 ENOG4105CAS nag kinase C2H98_09020 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) C2H98_09025 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase C2H98_09030 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) C2H98_09035 ENOG4107QR9 Iron-sulfur cluster binding protein C2H98_09040 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) C2H98_09045 ENOG4105JXH GntR family transcriptional regulator C2H98_09050 ENOG4105DAA L-lactate C2H98_09055 ENOG4105CVM Molybdenum cofactor synthesis domain protein C2H98_09060 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C2H98_09065 ENOG4105VG1 fes assembly suf system protein C2H98_09070 ENOG4108MXZ Esterase C2H98_09075 ENOG4108KP7 hydrolase C2H98_09080 ENOG41073B9 C2H98_09090 ENOG4107AYK membrAne C2H98_09095 ENOG4105EPR degv family C2H98_09105 ENOG4105QNR S1 RNA binding domain protein C2H98_09110 ENOG4108VPT UPF0234 protein C2H98_09115 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C2H98_09135 ENOG4105CAQ asparagine synthetase C2H98_09145 ENOG4105VRR gCN5-related N-acetyltransferase C2H98_09160 ENOG4105FTV AraC Family Transcriptional Regulator C2H98_09170 ENOG4105EE0 oxidoreductase C2H98_09175 ENOG4105D9R oxidoreductase C2H98_09180 ENOG4106KNT transcriptional regulator C2H98_09195 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) C2H98_09210 ENOG4105CJ1 ABC, transporter C2H98_09215 ENOG4105C37 (CBS) domain C2H98_09220 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) C2H98_09225 ENOG4105WH1 Two component transcriptional regulator luxr family C2H98_09230 ENOG4105BZU Histidine kinase C2H98_09235 ENOG4105YHS UPF0344 protein C2H98_09240 ENOG4105ERH Fumarylacetoacetate hydrolase C2H98_09280 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation C2H98_09300 ENOG4108RCF TRANSCRIPTIONal C2H98_09305 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein C2H98_09310 ENOG41060YP C2H98_09325 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 C2H98_09330 ENOG4105DF9 Lipoate-protein, ligase C2H98_09335 ENOG4105ECB domain protein C2H98_09345 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) C2H98_09350 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) C2H98_09360 ENOG4105WH1 Two component transcriptional regulator luxr family C2H98_09365 ENOG4105ENE Histidine kinase C2H98_09405 ENOG4105K59 histidine triad (HIT) protein C2H98_09410 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) C2H98_09455 ENOG4106D4I domain protein C2H98_09460 ENOG4107VRP DNA repair exonuclease C2H98_09465 ENOG4105RHA ABC transporter, permease C2H98_09470 ENOG4108IUX (ABC) transporter C2H98_09475 ENOG4105C7N Xanthine uracil vitamin C permease C2H98_09480 ENOG4105D4P Coproporphyrinogen iii oxidase C2H98_09490 ENOG4105YWU small acid-soluble spore protein C2H98_09495 ENOG4105WZB UPF0342 protein C2H98_09510 ENOG410839P C2H98_09515 ENOG410839P C2H98_09545 ENOG4108SA1 esterase C2H98_09565 ENOG410874W AraC family transcriptional regulator C2H98_09570 ENOG4105NIV Esterase C2H98_09575 ENOG4105BZ1 (ABC) transporter C2H98_09580 ENOG4105BZ1 (ABC) transporter C2H98_09600 ENOG4105EC8 Methyl-accepting chemotaxis C2H98_09610 ENOG4105C37 (CBS) domain C2H98_09615 ENOG4105C37 (CBS) domain C2H98_09620 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C2H98_09625 ENOG4105D7N magnesium and cobalt transport protein CorA C2H98_09630 ENOG4108JYZ YitT family C2H98_09640 ENOG4105CJ1 ABC, transporter C2H98_09645 ENOG4108TU7 Inherit from COG: (ABC) transporter C2H98_09665 ENOG4105D7K pfkb domain protein C2H98_09675 ENOG4105CPQ Dehydrogenase C2H98_09680 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C2H98_09690 ENOG4105M4P Tetr family transcriptional regulator C2H98_09705 ENOG4108RYK Nad-dependent epimerase dehydratase C2H98_09710 ENOG4108Z40 Transcriptional regulator C2H98_09725 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) C2H98_09730 ENOG4105KNA -acetyltransferase C2H98_09750 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase C2H98_09765 ENOG4105D29 Helix-turn-helix type 11 domain protein C2H98_09790 ENOG4105RXJ C2H98_09795 ENOG4105KPY Small multidrug resistance protein C2H98_09800 ENOG4105KBX Transcriptional regulator, TetR family C2H98_09805 ENOG4108KSA LysR family transcriptional regulator C2H98_09820 ENOG4105C7N Xanthine uracil vitamin C permease C2H98_09845 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase C2H98_09865 ENOG4108YBP pseudouridine synthase C2H98_09870 ENOG4107BMA Transglycosylase associated protein C2H98_09880 ENOG4105E1F short-chain dehydrogenase reductase C2H98_09885 ENOG4107GRR phosphate transport regulator C2H98_09890 ENOG4105CJ3 phosphate transporter C2H98_09900 ENOG4108JYZ YitT family C2H98_09905 ENOG4105BZU Histidine kinase C2H98_09910 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C2H98_09920 ENOG4107QJZ Glycosyl transferase, family 2 C2H98_09930 ENOG4105BZU Histidine kinase C2H98_09935 ENOG4105II7 pyrroline-5-carboxylate reductase C2H98_09950 ENOG4108IMY Transcriptional regulator C2H98_09960 ENOG4105C22 threonyL-tRNA synthetase C2H98_09965 ENOG4105ECK Fatty Acid Desaturase C2H98_09970 ENOG4108ZGX Histidine kinase C2H98_09975 ENOG4108S01 response regulator C2H98_09985 ENOG4105JQZ Methyltransferase C2H98_09990 ENOG4105DMW Dehydrogenase reductase C2H98_09995 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) C2H98_10005 ENOG4105CNT hydrolase family 2 C2H98_10010 ENOG4105CT4 transporter C2H98_10015 ENOG41075H3 AraC family transcriptional regulator C2H98_10020 ENOG4105UNS Pfam:DUF419 C2H98_10025 ENOG410631K Membrane C2H98_10030 ENOG4106AXJ AraC family transcriptional regulator C2H98_10035 ENOG4105KAC Antibiotic biosynthesis monooxygenase C2H98_10065 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain C2H98_10070 ENOG4108URH decarboxylase C2H98_10105 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr C2H98_10115 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase C2H98_10165 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) C2H98_10170 ENOG41082W1 Cupin 2, conserved barrel domain protein C2H98_10215 ENOG4108VHC Short-chain dehydrogenase reductase Sdr C2H98_10220 ENOG4105KVH Transcriptional regulator C2H98_10225 ENOG4105DHI Methyltransferase C2H98_10230 ENOG4107QK4 glycoside hydrolase, family 3 domain protein C2H98_10235 ENOG4105C5Y PTS System C2H98_10240 ENOG4105ID8 Transcriptional regulator, ARAC family C2H98_10245 ENOG4105E6M Sulphatase-modifying factor protein C2H98_10265 ENOG4105C4X radical SAM domain protein C2H98_10270 ENOG4105C5Y PTS System C2H98_10275 ENOG4105CS2 ec 3.2.1.21 C2H98_10280 ENOG4108Q3X Transcriptional regulator C2H98_10290 ENOG4105CPC Aldo Keto reductase C2H98_10305 ENOG4105WD1 Membrane C2H98_10335 ENOG4105CYN Serine protein kinase C2H98_10340 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) C2H98_10345 ENOG4108DBC nitroreductase C2H98_10360 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) C2H98_10375 ENOG4105CNH Multidrug resistance protein MdtL C2H98_10380 ENOG4108QTI )-transporter C2H98_10395 ENOG4105E2A Dehydrogenase C2H98_10425 ENOG4107ZTW SNARE associated Golgi C2H98_10430 ENOG4105KVH Transcriptional regulator C2H98_10445 ENOG4105PDP Short chain dehydrogenase C2H98_10460 ENOG4105C6T cysteine synthase C2H98_10475 ENOG4107QNK )-transporter C2H98_10480 ENOG4105EQD regulatoR C2H98_10485 ENOG4105C2F Histidine kinase C2H98_10500 ENOG4107V0Z fmn reductase C2H98_10510 ENOG4108XFG YwhD family C2H98_10520 ENOG4105CUC YeeE YedE family protein C2H98_10525 ENOG4108NGU Transcriptional regulator C2H98_10535 ENOG4105CS1 NAD(P)H quinone oxidoreductase C2H98_10540 ENOG4105FBA Phospholipase Carboxylesterase C2H98_10545 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase C2H98_10550 ENOG4107XWI flavin reductase domain protein, FMN-binding C2H98_10555 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase C2H98_10560 ENOG41090MY MarR family Transcriptional regulator C2H98_10585 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C2H98_10630 ENOG4105CS2 ec 3.2.1.21 C2H98_10640 ENOG4105VUF Transcriptional regulator C2H98_10645 ENOG4108VHC Short-chain dehydrogenase reductase Sdr C2H98_10650 ENOG4108KB1 transcriptional regulator, arac family C2H98_10665 ENOG4105C2C drug resistance transporter, Bcr CflA C2H98_10675 ENOG4105P4J Allophanate hydrolase, subunit 1 C2H98_10680 ENOG4105CS2 ec 3.2.1.21 C2H98_10685 ENOG4105C5Y PTS System C2H98_10690 ENOG4105CID antiterminator C2H98_10695 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C2H98_10720 ENOG4105MU9 integral membrane protein C2H98_10725 ENOG4105CX8 fg-gap repeat protein C2H98_10735 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component C2H98_10745 ENOG4105E0S extracellular solute-binding protein family 1 C2H98_10750 ENOG41075H3 AraC family transcriptional regulator C2H98_10755 ENOG4107TDE lipolytic protein G-D-S-L family C2H98_10760 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) C2H98_10765 ENOG4105F5H Glycosyl Hydrolase Family 88 C2H98_10770 ENOG4105E0A ABC, transporter C2H98_10775 ENOG4108IHU transport system permease protein C2H98_10780 ENOG4105DQ5 transport system permease protein C2H98_10785 ENOG4108MES Periplasmic binding protein C2H98_10795 ENOG4108IPJ Membrane C2H98_10805 ENOG4105RHY Pfam:UPF0157 C2H98_10830 ENOG4105DSE periplasmic solute binding protein C2H98_10830 ENOG4105DSE periplasmic solute binding protein C2H98_10835 ENOG4108MEK Metal-binding protein YodA C2H98_10840 ENOG4105C0R drug resistance transporter emrb qaca subfamily C2H98_10865 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) C2H98_10880 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) C2H98_10935 ENOG4108Z7R Chaperone CsaA C2H98_10945 ENOG4107GJV short-chain dehydrogenase reductase C2H98_10975 ENOG4105EMD TRANSCRIPTIONal C2H98_10980 ENOG4105CS2 ec 3.2.1.21 C2H98_10985 ENOG4105CK1 PTS System C2H98_11000 ENOG4105VCP PTS System C2H98_11020 ENOG4105BZ1 (ABC) transporter C2H98_11035 ENOG4108SWU Histidine kinase C2H98_11040 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C2H98_11230 ENOG4105G5W regulator Fur family C2H98_11235 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C2H98_11245 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase C2H98_11250 ENOG4107NBY Membrane C2H98_11255 ENOG4105BZ1 (ABC) transporter C2H98_11275 ENOG4105CAN Short-chain dehydrogenase reductase Sdr C2H98_11280 ENOG4106BXE C2H98_11285 ENOG4105CEN a g-specific adenine glycosylase C2H98_11290 ENOG41067AE Membrane-bound metal-dependent hydrolase C2H98_11300 ENOG4105XHU Acid-soluble spore protein K C2H98_11310 ENOG410902V Modulates RecA activity (By similarity) C2H98_11320 ENOG4106Z5D Glycoside Hydrolase Family 43 C2H98_11325 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) C2H98_11330 ENOG4108S4H thioesterase Superfamily protein C2H98_11345 ENOG410807C QueT transporter C2H98_11350 ENOG4105JAB phenazine biosynthesis protein, phzf family C2H98_11355 ENOG4105CDW Resistance protein C2H98_11365 ENOG4105FCD Major Facilitator C2H98_11370 ENOG4105DY9 regulatoR C2H98_11375 ENOG4108HRK Histidine kinase C2H98_11385 ENOG410746C Acid-soluble spore protein O C2H98_11390 ENOG4105C6X Major Facilitator C2H98_11395 ENOG4105C8Q Methyl-accepting chemotaxis C2H98_11420 ENOG4105BZ1 (ABC) transporter C2H98_11425 ENOG4105BZ1 (ABC) transporter C2H98_11435 ENOG4105J37 C2H98_11440 ENOG4108AEY RNA polymerase sigma factor C2H98_11445 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C2H98_11450 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C2H98_11455 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) C2H98_11465 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) C2H98_11490 ENOG4105C3S Mate efflux family protein C2H98_11505 ENOG4108WV1 Pfam:DUF477 C2H98_11510 ENOG4105DQX Zinc finger domain C2H98_11515 ENOG4105CNG UPF0061 protein C2H98_11520 ENOG4105BZU Histidine kinase C2H98_11535 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) C2H98_11555 ENOG4105E5Q amino acid AbC transporter C2H98_11565 ENOG4105KVH Transcriptional regulator C2H98_11570 ENOG4105ECR NmrA family C2H98_11580 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) C2H98_11605 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) C2H98_11610 ENOG4108HWW ABC transporter C2H98_11615 ENOG4105C2J ABC transporter C2H98_11620 ENOG4105DFW ABC transporter C2H98_11625 ENOG4105EQD regulatoR C2H98_11640 ENOG4108UTW Plays a role in the regulation of phosphate uptake C2H98_11645 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) C2H98_11650 ENOG4105E2Z phosphate ABC transporter (Permease C2H98_11655 ENOG4105C8U phosphate abc transporter C2H98_11660 ENOG4105CVA phosphate C2H98_11675 ENOG4105E90 ABC transporter C2H98_11680 ENOG4108IJ8 ABC transporter C2H98_11695 ENOG4105IIP Membrane C2H98_11710 ENOG4107RSM transcriptional regulator C2H98_11725 ENOG4108W15 Protein of unknown function (DUF1456) C2H98_11735 ENOG4105BZU Histidine kinase C2H98_11745 ENOG4105CGH 5'-nucleotidase C2H98_11755 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) C2H98_11760 ENOG4105C5H ABC transporter C2H98_11830 ENOG4105D5D udp-galactopyranose mutase C2H98_11835 ENOG41088M2 Glycosyl transferase family 2 C2H98_11845 ENOG4107QK4 glycoside hydrolase, family 3 domain protein C2H98_11860 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C2H98_11875 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C2H98_11880 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) C2H98_11955 ENOG4105UPD Calcium Proton C2H98_11960 ENOG4108ISG Major Facilitator C2H98_11965 ENOG4105C59 p-type ATPase C2H98_11970 ENOG4107U9T Pfam:Ribonuclease_BN C2H98_11980 ENOG4105KJF protein tyrosine phosphatase C2H98_11985 ENOG41068PA UPF0435 protein C2H98_11990 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) C2H98_11995 ENOG4107RKG DJ-1/PfpI family C2H98_12000 ENOG4107414 GntR family transcriptional regulator C2H98_12005 ENOG4108IMY Transcriptional regulator C2H98_12020 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) C2H98_12025 ENOG4105DD7 kinase (PfkB family C2H98_12030 ENOG4105ER2 Ompa motb domain protein C2H98_12035 ENOG4105E14 MotA TolQ exbB proton channel C2H98_12045 ENOG4105C9U ATP-dependent DNA helicase RecQ C2H98_12050 ENOG4107URF beta-phospho-glucomutase C2H98_12065 ENOG410855V Acylphosphatase C2H98_12075 ENOG4106I4J membrane C2H98_12085 ENOG4108S4H thioesterase Superfamily protein C2H98_12110 ENOG4105WH1 Two component transcriptional regulator luxr family C2H98_12140 ENOG4105E1K spore germination protein C2H98_12160 ENOG4105FDU atp-dependent rna helicase C2H98_12170 ENOG4105BZ1 (ABC) transporter C2H98_12175 ENOG4105BZ1 (ABC) transporter C2H98_12185 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C2H98_12195 ENOG4108JQ7 (ABC) transporter C2H98_12200 ENOG4105C3U ABC transporter C2H98_12220 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C2H98_12240 ENOG4105CFH Aspartokinase C2H98_12255 ENOG4108UMN azlc family C2H98_12265 ENOG4105CX6 glutaminyL-tRNA synthetase C2H98_12280 ENOG4105BZ1 (ABC) transporter C2H98_12285 ENOG4105CJA serine threonine protein kinase C2H98_12310 ENOG4105K7K Transcriptional regulator C2H98_12330 ENOG4105DY9 regulatoR C2H98_12340 ENOG41063PX domain protein C2H98_12345 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C2H98_12355 ENOG4105G6Z alkaline phosphatase C2H98_12365 ENOG4106SCS STAS domain C2H98_12370 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase C2H98_12375 ENOG4105KVH Transcriptional regulator C2H98_12390 ENOG4105BZU Histidine kinase C2H98_12400 ENOG4105EQD regulatoR C2H98_12405 ENOG4105C2F Histidine kinase C2H98_12425 ENOG41069ER domain protein C2H98_12430 ENOG4108W0I acetyltransferase C2H98_12445 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) C2H98_12455 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C2H98_12460 ENOG4105CBD Diacylglycerol kinase C2H98_12480 ENOG4105DU6 RNA polymerase C2H98_12490 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) C2H98_12500 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) C2H98_12505 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C2H98_12510 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) C2H98_12515 ENOG4107RBI VanW family C2H98_12520 ENOG4105K56 Transcriptional regulator C2H98_12540 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) C2H98_12545 ENOG4105C4R Atp-dependent dna helicase C2H98_12550 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) C2H98_12555 ENOG4105KGF protein, YerC YecD C2H98_12560 ENOG4108R5T secreted protein C2H98_12575 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C2H98_12580 ENOG4105C12 Phosphoribosylglycinamide synthetase C2H98_12585 ENOG4105DC1 bifunctional purine biosynthesis protein purh C2H98_12590 ENOG4108V3E phosphoribosylglycinamide formyltransferase C2H98_12595 ENOG4105CXB phosphoribosylaminoimidazole synthetase C2H98_12605 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii C2H98_12610 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I C2H98_12615 ENOG4105VR9 phosphoribosylformylglycinamidine synthase C2H98_12620 ENOG4105C8V SAICAR synthetase C2H98_12625 ENOG4105C83 adenylosuccinate lyase C2H98_12630 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit C2H98_12635 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) C2H98_12690 ENOG4105FQP Beta-lactamase C2H98_12715 ENOG4105CID antiterminator C2H98_12720 ENOG4105C7N Xanthine uracil vitamin C permease C2H98_12725 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) C2H98_12735 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) C2H98_12740 ENOG4105HF0 Membrane C2H98_12745 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) C2H98_12760 ENOG4105C7R Atpase associated with various cellular activities aaa_3 C2H98_12765 ENOG4106FN3 tellurium resistance protein C2H98_12770 ENOG4105CID antiterminator C2H98_12775 ENOG4105CS2 ec 3.2.1.21 C2H98_12780 ENOG4105C5Y PTS System C2H98_12790 ENOG4105D2H Uronic isomerase C2H98_12800 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) C2H98_12810 ENOG4108KPW sugar kinase C2H98_12830 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter C2H98_12835 ENOG4107Y7Q pfkb domain protein C2H98_12840 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine C2H98_12845 ENOG4105FDP GntR family transcriptional regulator C2H98_12870 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B C2H98_12875 ENOG4108KAM Transcriptional regulator C2H98_12885 ENOG4105E5W Transporter C2H98_12895 ENOG4105E5J UV damage endonuclease C2H98_12905 ENOG410606W general stress protein C2H98_12920 ENOG4105F6S Spore photoproduct lyase C2H98_12930 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C2H98_12945 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) C2H98_12960 ENOG4105C6K Malic enzyme C2H98_12965 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) C2H98_12970 ENOG4108MRH transcriptional regulatory protein C2H98_12985 ENOG4105C8J )-transporter C2H98_12990 ENOG4105C8Q Methyl-accepting chemotaxis C2H98_13005 ENOG4105QE3 oxidoreductase C2H98_13010 ENOG4105CN5 Metallo-Beta-Lactamase C2H98_13015 ENOG4105D9R oxidoreductase C2H98_13025 ENOG4105F3R pts system mannose fructose sorbose family iid C2H98_13030 ENOG4105ETZ PTS System C2H98_13045 ENOG4108HKT sucrose-6-phosphate hydrolase C2H98_13075 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase C2H98_13085 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) C2H98_13100 ENOG4105C4R Atp-dependent dna helicase C2H98_13135 ENOG4105VEM Conserved domain protein C2H98_13155 ENOG4105VTR Integrase C2H98_13170 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) C2H98_13175 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) C2H98_13180 ENOG4108TYN CAAX amino terminal protease family protein C2H98_13190 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) C2H98_13195 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C2H98_13200 ENOG4105C5H ABC transporter C2H98_13205 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C2H98_13210 ENOG410801F ribosomal-protein-alanine acetyltransferase C2H98_13215 ENOG41072GX Peptidase M22 Glycoprotease C2H98_13220 ENOG4105K8N protein family UPF0079, ATPase C2H98_13315 ENOG41064BQ Phosphatase C2H98_13325 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) C2H98_13330 ENOG4105WN5 stage II sporulation protein C2H98_13335 ENOG4107SGM protein serine threonine phosphatase C2H98_13340 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase C2H98_13345 ENOG4105FUA antagonist C2H98_13350 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) C2H98_13365 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein C2H98_13370 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) C2H98_13380 ENOG4105CKV Membrane C2H98_13385 ENOG410905X membrane-flanked domain protein C2H98_13390 ENOG4105C1J atp-dependent rna helicase C2H98_13400 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) C2H98_13405 ENOG4105CPF Cell wall formation (By similarity) C2H98_13420 ENOG4108WBT adenosyltransferase C2H98_13430 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) C2H98_13435 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) C2H98_13440 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) C2H98_13450 ENOG4107QZB decarboxylase C2H98_13455 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) C2H98_13460 ENOG4105E0A ABC, transporter C2H98_13465 ENOG4105EHG Permease protein C2H98_13470 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) C2H98_13475 ENOG4105PW4 Sugar fermentation stimulation protein homolog C2H98_13485 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) C2H98_13490 ENOG4105CJW magnesium transporter C2H98_13500 ENOG4105HUF DNA protection during starvation protein C2H98_13505 ENOG4107ZYR domain protein C2H98_13515 ENOG4105PXI polysaccharide deacetylase C2H98_13530 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C2H98_13540 ENOG4107RUE extracellular solute-binding protein family 1 C2H98_13545 ENOG4105D38 putrescine abc transporter C2H98_13550 ENOG4105F38 ABC transporter, permease C2H98_13575 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) C2H98_13580 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) C2H98_13585 ENOG4105C0H protease C2H98_13590 ENOG4105BZU Histidine kinase C2H98_13595 ENOG4105EVU fructokinase C2H98_13600 ENOG4105EE0 oxidoreductase C2H98_13610 ENOG4108IPW abc transporter atp-binding protein C2H98_13615 ENOG4105CM4 permease protein C2H98_13620 ENOG4105DHS permease protein C2H98_13635 ENOG4105BZ9 Cytochrome C oxidase, subunit I C2H98_13640 ENOG4105E2S oxidase) subunit II C2H98_13645 ENOG4105BZ4 penicillin-binding protein C2H98_13650 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase C2H98_13660 ENOG4105ETD TRANSCRIPTIONal C2H98_13670 ENOG4105C37 (CBS) domain C2H98_13680 ENOG4106F5Q Membrane C2H98_13685 ENOG4105C01 Dihydroxy-acid dehydratase C2H98_13690 ENOG4107SET aldo keto reductase C2H98_13705 ENOG4105E0A ABC, transporter C2H98_13715 ENOG4108JQ7 (ABC) transporter C2H98_13720 ENOG4107SN7 NLP P60 protein C2H98_13725 ENOG4105DTQ mandelate racemase muconate lactonizing C2H98_13730 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A C2H98_13740 ENOG4105C3U ABC transporter C2H98_13745 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C2H98_13750 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C2H98_13755 ENOG4108ME1 Peptidase M55 D-aminopeptidase C2H98_13770 ENOG4105C1Q protoporphyrinogen oxidase C2H98_13775 ENOG4108Z40 Transcriptional regulator C2H98_13780 ENOG4107EF8 Glycosyl transferase (Group 1 C2H98_13795 ENOG4105QZI O-Antigen Polymerase C2H98_13805 ENOG4107RA4 Glycosyl transferase (Group 1 C2H98_13810 ENOG4105PSV Polysaccharide Biosynthesis Protein C2H98_13815 ENOG4105D3Q Sugar transferase C2H98_13830 ENOG4108JJB ABC transporter C2H98_13845 ENOG4105CEP NADH dehydrogenase C2H98_13885 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein C2H98_13890 ENOG4105E0C molybdate abc transporter C2H98_13900 ENOG4105C72 UPF0176 protein C2H98_13910 ENOG4105CK1 PTS System C2H98_13930 ENOG4105HX0 Transcriptional regulator C2H98_13935 ENOG4105CI1 PTS System C2H98_13940 ENOG4105F8D glycoside hydrolase family 4 C2H98_13945 ENOG41067QW Transcriptional regulator C2H98_13955 ENOG4105CHH sulfate transporter C2H98_13965 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein C2H98_13970 ENOG4105C5S asparaginyl-tRNA synthetase C2H98_13975 ENOG4105EWU Squalene--hopene cyclase C2H98_13985 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) C2H98_14005 ENOG4108PSK reductase C2H98_14030 ENOG4105EQ0 Major Facilitator superfamily C2H98_14035 ENOG4108JGH Tetr family transcriptional regulator C2H98_14050 ENOG4105BZU Histidine kinase C2H98_14055 ENOG4105BZU Histidine kinase C2H98_14060 ENOG4108Z73 Siroheme synthase C2H98_14065 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein C2H98_14070 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C2H98_14075 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) C2H98_14080 ENOG4107RIQ Sulfate adenylate transferase C2H98_14090 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) C2H98_14105 ENOG4105DUM transcriptional regulator, lysR family C2H98_14110 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) C2H98_14115 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) C2H98_14125 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C2H98_14135 ENOG4105EG2 ABC transporter, permease C2H98_14145 ENOG4107FKK extracellular solute-binding protein family 1 C2H98_14185 ENOG4105I4A GCN5-related N-acetyltransferase C2H98_14195 ENOG4108KGH TRANSCRIPTIONal C2H98_14205 ENOG4105EMN RNA polymerase sigma factor C2H98_14230 ENOG4108YM7 Gcn5-related n-acetyltransferase C2H98_14240 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase C2H98_14245 ENOG4105C3M thioredoxin reductase C2H98_14260 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) C2H98_14265 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) C2H98_14270 ENOG4105D29 Helix-turn-helix type 11 domain protein C2H98_14285 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase C2H98_14290 ENOG41075D4 Aminoglycoside 6-adenylyltransferase C2H98_14310 ENOG4105CZN Potassium uptake protein C2H98_14325 ENOG4105E0A ABC, transporter C2H98_14330 ENOG4105TVJ transport system, permease C2H98_14335 ENOG4105DQ5 transport system permease protein C2H98_14350 ENOG4105DJ2 Major Facilitator Superfamily C2H98_14365 ENOG4105CHR reductase C2H98_14370 ENOG4105DJ2 Major Facilitator Superfamily C2H98_14375 ENOG4105F3R pts system mannose fructose sorbose family iid C2H98_14385 ENOG4108EQA pts system C2H98_14390 ENOG4108EQA pts system C2H98_14395 ENOG4105FDP GntR family transcriptional regulator C2H98_14400 ENOG4108X79 transcriptional regulator C2H98_14415 ENOG4105VI0 Pts system, glucitol sorbitol-specific C2H98_14425 ENOG410787A Pts system, glucitol sorbitol-specific C2H98_14430 ENOG4105CPQ Dehydrogenase C2H98_14440 ENOG4105C26 Dehydrogenase C2H98_14450 ENOG4105KVH Transcriptional regulator C2H98_14480 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C2H98_14510 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C2H98_14525 ENOG4108TVJ Nitroreductase C2H98_14535 ENOG4105FS7 Transcriptional regulator C2H98_14560 ENOG41067TZ transcriptional regulator, MarR family C2H98_14600 ENOG4106WTF Glycosyl transferase, family 2 C2H98_14610 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) C2H98_14615 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) C2H98_14620 ENOG4107U5W ybbr family C2H98_14625 ENOG4105C8B TIGR00159 family C2H98_14635 ENOG4105EMN RNA polymerase sigma factor C2H98_14710 ENOG4108NMV polysaccharide deacetylase C2H98_14720 ENOG4105D1F ATP-binding protein C2H98_14755 ENOG41079CX C2H98_14785 ENOG4108UJD 30S ribosomal protein S9 C2H98_14790 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) C2H98_14800 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) C2H98_14805 ENOG4108JJB ABC transporter C2H98_14810 ENOG4108JJB ABC transporter C2H98_14815 ENOG4108ZT0 50S ribosomal protein l17 C2H98_14820 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C2H98_14830 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits C2H98_14835 ENOG41067V7 50S ribosomal protein L36 C2H98_14840 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) C2H98_14845 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) C2H98_14850 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) C2H98_14855 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) C2H98_14860 ENOG4105VPB 50S ribosomal protein L30 C2H98_14865 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) C2H98_14870 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) C2H98_14875 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) C2H98_14880 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) C2H98_14900 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) C2H98_14905 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal C2H98_14910 ENOG41082SA 50s ribosomal protein l29 C2H98_14915 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) C2H98_14920 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) C2H98_14925 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) C2H98_14930 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) C2H98_14935 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity C2H98_14940 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) C2H98_14945 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) C2H98_14950 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) C2H98_14960 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) C2H98_14970 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) C2H98_14975 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) C2H98_14980 ENOG4105XPM ribosomal protein C2H98_14985 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C2H98_14990 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C2H98_14995 ENOG4107Y49 methyltransferase C2H98_15000 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) C2H98_15005 ENOG4108VZM 50s ribosomal protein L10 C2H98_15010 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) C2H98_15020 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) C2H98_15030 ENOG4107FTN 50S ribosomal protein L33 C2H98_15035 ENOG4105QIV RNA polymerase C2H98_15040 ENOG4105M0M Tetracycline resistance protein C2H98_15045 ENOG4105C2N RNA methyltransferase TrmH family group 3 C2H98_15055 ENOG4105C8N cysteinyl-tRNA synthetase C2H98_15060 ENOG4105D7W serine acetyltransferase C2H98_15065 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) C2H98_15070 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) C2H98_15075 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) C2H98_15080 ENOG4105CTP PilT protein domain protein C2H98_15085 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) C2H98_15095 ENOG41066A3 ATP guanido phosphotransferase C2H98_15100 ENOG4108Z0C Uvrb UvrC protein C2H98_15185 ENOG4105CRK lysyL-tRNA synthetase C2H98_15190 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) C2H98_15200 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase C2H98_15205 ENOG4105KRF dihydroneopterin aldolase C2H98_15210 ENOG4105EEI dihydropteroate synthase C2H98_15215 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 C2H98_15220 ENOG4105DDQ anthranilate synthase C2H98_15225 ENOG4105CRQ synthase (Component I) C2H98_15230 ENOG4105C6T cysteine synthase C2H98_15235 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) C2H98_15240 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) C2H98_15245 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) C2H98_15250 ENOG4108UGV hypoxanthine phosphoribosyltransferase C2H98_15255 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) C2H98_15280 ENOG41060GV RNA binding s1 domain protein C2H98_15295 ENOG4105VYY sporulation protein yabp C2H98_15300 ENOG41082I2 s4 domain protein C2H98_15305 ENOG4108IY2 MazG family C2H98_15325 ENOG4108M14 stage v sporulation protein t C2H98_15330 ENOG4108JA2 transcriptioN-repair coupling factor C2H98_15340 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) C2H98_15345 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) C2H98_15350 ENOG4105C5T Phosphoribosyl pyrophosphate synthase C2H98_15355 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) C2H98_15360 ENOG4105K4W Could be involved in septation (By similarity) C2H98_15365 ENOG4105KME endoribonuclease L-psp C2H98_15370 ENOG4105DFT pur operon repressor C2H98_15375 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) C2H98_15385 ENOG4105W42 Veg protein C2H98_15390 ENOG4105XFA sporulation peptidase YabG C2H98_15395 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) C2H98_15400 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) C2H98_15405 ENOG41069ER domain protein C2H98_15410 ENOG4105F8V Hydrolase, tatD family C2H98_15415 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) C2H98_15420 ENOG4105KRN Transcriptional regulator, abrb family C2H98_15425 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) C2H98_15430 ENOG4105VC4 domain protein C2H98_15435 ENOG41060K3 Methyltransferase C2H98_15440 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) C2H98_15445 ENOG4105MA4 psp1 domain protein C2H98_15450 ENOG4105FA2 dna polymerase iii C2H98_15460 ENOG4105X0R protein from nitrogen regulatory protein P-II C2H98_15470 ENOG4105CXN decarboxylase C2H98_15505 ENOG41067KS pro-sigma K processing C2H98_15515 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) C2H98_15520 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) C2H98_15535 ENOG4108Z6B deaminase C2H98_15540 ENOG4105GTG Isochorismatase C2H98_15545 ENOG4105VRS hydrolase family 18 C2H98_15550 ENOG4105D06 uba thif-type nad fad binding protein C2H98_15555 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) C2H98_15570 ENOG4108VEU Thiamine monophosphate synthase C2H98_15580 ENOG4105ZMH deoxynucleoside kinase C2H98_15590 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) C2H98_15595 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) C2H98_15600 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) C2H98_15610 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) C2H98_15645 ENOG4105DHT Metal Dependent Phosphohydrolase C2H98_15650 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C2H98_15655 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C2H98_15665 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) C2H98_15670 ENOG410848D S4 domain protein YaaA C2H98_15675 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) C2H98_15680 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) C2H98_15685 ENOG4105VG0 50S ribosomal protein l34 C2H98_15690 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) C2H98_15695 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins C2H98_15700 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein C2H98_15705 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) C2H98_15720 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) C2H98_15730 ENOG4107QJE Chromosome Partitioning Protein C2H98_15735 ENOG4105FA0 parb-like partition protein C2H98_15740 ENOG4108ZDA Sporulation protein YyaC C2H98_15750 ENOG4105D8X mechanosensitive ion channel C2H98_15755 ENOG4105VDK protein, conserved in bacteria C2H98_15760 ENOG4105C3G gtp-binding protein C2H98_15770 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) C2H98_15775 ENOG4108UUM single-stranded DNA-binding protein C2H98_15780 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) C2H98_15785 ENOG4105BZR domain protein C2H98_15790 ENOG4105K9Q Binds to the 23S rRNA (By similarity) C2H98_15795 ENOG4105CDU Replicative dna helicase C2H98_15805 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) C2H98_15810 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis C2H98_15835 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C2H98_15840 ENOG4105BZU Histidine kinase C2H98_15855 ENOG4105Q2H domain protein C2H98_15860 ENOG4105C0H protease C2H98_15870 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) C2H98_15875 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) C2H98_15880 ENOG4105C4R Atp-dependent dna helicase C2H98_16005 ENOG4105DZR Type I site-specific deoxyribonuclease C2H98_16010 ENOG4105VEM Conserved domain protein C2H98_16050 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C2H98_16055 ENOG4108PCN EamA-like transporter family C2H98_16065 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C2H98_16080 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein C2H98_16085 ENOG4105E0C molybdate abc transporter C2H98_16095 ENOG4108IUE nitrate reductase beta subunit C2H98_16100 ENOG4105R3A Nitrate reductase C2H98_16115 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C2H98_16120 ENOG4105D06 uba thif-type nad fad binding protein C2H98_16125 ENOG4105CVM Molybdenum cofactor synthesis domain protein C2H98_16130 ENOG4108ZAF Molybdopterin C2H98_16140 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b C2H98_16145 ENOG4107V6Q Cyclic nucleotide-binding domain C2H98_16150 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) C2H98_16155 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) C2H98_16185 ENOG4107Y9U Membrane C2H98_16200 ENOG4105EAB amino acid AbC transporter C2H98_16205 ENOG4105E5Q amino acid AbC transporter C2H98_16210 ENOG4105CDA abc transporter atp-binding protein C2H98_16225 ENOG4105D03 DNA-3-methyladenine glycosylase II C2H98_16240 ENOG4105T38 integral membrane protein C2H98_16250 ENOG4105BZU Histidine kinase C2H98_16255 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C2H98_16265 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) C2H98_16270 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein C2H98_16275 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) C2H98_16280 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD C2H98_16285 ENOG4105C1J atp-dependent rna helicase C2H98_16290 ENOG4105C8J )-transporter C2H98_16295 ENOG4105D8G Major Facilitator superfamily C2H98_16300 ENOG4108Y4K DNA-binding transcriptional activator C2H98_16310 ENOG4105E5Q amino acid AbC transporter C2H98_16315 ENOG4105CDA abc transporter atp-binding protein C2H98_16325 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA C2H98_16345 ENOG4105BZU Histidine kinase C2H98_16355 ENOG4105DEN Luciferase family C2H98_16360 ENOG4105DEN Luciferase family C2H98_16365 ENOG4105X5K response regulator receiver protein C2H98_16375 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C2H98_16380 ENOG4108ZUB Lysine exporter protein (Lyse ygga) C2H98_16385 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C2H98_16390 ENOG4108UMI ABC transporter, permease C2H98_16395 ENOG4105D01 (LipO)protein C2H98_16400 ENOG4105DWT malate dehydrogenase (quinone) C2H98_16405 ENOG4105DSG hydrolase family 43 C2H98_16410 ENOG4105VZJ PTS System C2H98_16415 ENOG4105CK1 PTS System C2H98_16425 ENOG4105CS2 ec 3.2.1.21 C2H98_16430 ENOG4105EMD TRANSCRIPTIONal C2H98_16455 ENOG4108JU3 Alkyl hydroperoxide reductase C2H98_16465 ENOG4107RZC phospholipase d C2H98_16475 ENOG4108IUW ABC transporter C2H98_16495 ENOG41065RQ ADP-ribosylation crystallin J1 C2H98_16515 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component C2H98_16520 ENOG4105DRS transport system, permease C2H98_16525 ENOG4107QK4 glycoside hydrolase, family 3 domain protein C2H98_16530 ENOG4107T40 Inherit from COG: Glycosyltransferase 36 C2H98_16535 ENOG4105ETE Transcriptional regulator (LacI family C2H98_16540 ENOG4108SEA Esterase C2H98_16545 ENOG4106N3A copper homeostasis protein cutc C2H98_16550 ENOG4105CUT histidyl-tRNA synthetase C2H98_16565 ENOG4105D65 subunit l C2H98_16570 ENOG4105HC0 Na H antiporter C2H98_16575 ENOG4105MKQ Monovalent cation H antiporter subunit C C2H98_16580 ENOG4108JPZ Monovalent cation H antiporter subunit D C2H98_16585 ENOG4105SC1 monovalent cation H antiporter subunit E C2H98_16595 ENOG4105KJM monovalent cation h antiporter subunit g C2H98_16600 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) C2H98_16605 ENOG4107QM2 Aldo Keto reductase C2H98_16625 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C2H98_16630 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C2H98_16640 ENOG4108JQ7 (ABC) transporter C2H98_16650 ENOG4105BZU Histidine kinase C2H98_16655 ENOG4105BZU Histidine kinase C2H98_16660 ENOG4108MJI response regulator C2H98_16690 ENOG4105CH6 catalase C2H98_16695 ENOG4105E1J oxidoreductase C2H98_16725 ENOG4107QNK )-transporter C2H98_16740 ENOG4107TDE lipolytic protein G-D-S-L family C2H98_16750 ENOG4105D2H Uronic isomerase C2H98_16755 ENOG4105CTX dehydratase C2H98_16760 ENOG4107KJX Transcriptional regulator C2H98_16770 ENOG4105CAY ferredoxin--nadp reductase C2H98_16780 ENOG4105CP9 extracellular ligand-binding receptor C2H98_16785 ENOG4105C32 Amino acid ABC transporter (Permease) C2H98_16790 ENOG4105CF8 branched-chain amino acid ABC transporter, permease C2H98_16795 ENOG4105C0Z ABC transporter C2H98_16800 ENOG4108IV0 ABC, transporter C2H98_16805 ENOG41080UX Methyltransferase C2H98_16810 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) C2H98_16815 ENOG4105ETU transcriptional activator (TenA C2H98_16820 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein C2H98_16825 ENOG4108JJB ABC transporter C2H98_16835 ENOG4105C5Y PTS System C2H98_16840 ENOG4107FKK extracellular solute-binding protein family 1 C2H98_16845 ENOG4105D56 permease protein C2H98_16850 ENOG4105EG2 ABC transporter, permease C2H98_16865 ENOG4107URF beta-phospho-glucomutase C2H98_16880 ENOG4105FKQ transcriptional regulator C2H98_16905 ENOG4105D7K pfkb domain protein C2H98_16915 ENOG4105UQX Mate efflux family protein C2H98_16920 ENOG41079KZ Major Facilitator Superfamily C2H98_16930 ENOG4105G9B Transcriptional regulator C2H98_16980 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase C2H98_16990 ENOG4105EMD TRANSCRIPTIONal C2H98_16995 ENOG4105CK1 PTS System C2H98_17000 ENOG4105CS2 ec 3.2.1.21 C2H98_17005 ENOG4105VZJ PTS System C2H98_17010 ENOG4105VCP PTS System C2H98_17025 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component C2H98_17030 ENOG4105D2X ABC transporter substrate-binding protein C2H98_17040 ENOG4108X79 transcriptional regulator C2H98_17045 ENOG4105VZJ PTS System C2H98_17050 ENOG4105CK1 PTS System C2H98_17055 ENOG4105VCP PTS System C2H98_17060 ENOG4105F8D glycoside hydrolase family 4 C2H98_17070 ENOG4108K8K Transcriptional regulator C2H98_17075 ENOG4105DCF alanine dehydrogenase C2H98_17080 ENOG4105CJ1 ABC, transporter C2H98_17095 ENOG4105DWK Membrane C2H98_17100 ENOG4107XM3 UPF0442 protein C2H98_17105 ENOG4105F8D glycoside hydrolase family 4 C2H98_17120 ENOG4108Z66 YbaK ebsC protein C2H98_17125 ENOG4108JJ8 (ABC) transporter C2H98_17130 ENOG4108JJ9 ABC, transporter C2H98_17135 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii C2H98_17140 ENOG4105C4M (Ubiquinol oxidase) subunit I C2H98_17150 ENOG4105J7I hydrolase C2H98_17165 ENOG4105CJ1 ABC, transporter C2H98_17180 ENOG4108TN2 lmbE family C2H98_17190 ENOG4105DWF phosphomethylpyrimidine kinase C2H98_17195 ENOG4108ZAF Molybdopterin C2H98_17205 ENOG4105D06 uba thif-type nad fad binding protein C2H98_17225 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) C2H98_17250 ENOG4107JTW chlorite dismutase C2H98_17255 ENOG4108IJ2 phosphate acetyltransferase C2H98_17260 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) C2H98_17265 ENOG4108VCI transcription factor, rsfa family C2H98_17270 ENOG4105C0R drug resistance transporter emrb qaca subfamily C2H98_17280 ENOG4105DCI Phosphohydrolase C2H98_17290 ENOG41069HH 4-oxalocrotonate tautomerase C2H98_17295 ENOG4108Z4T Peptidase M50 C2H98_17300 ENOG4108XFG YwhD family C2H98_17305 ENOG4105C98 muts2 protein C2H98_17320 ENOG4105BZ4 penicillin-binding protein C2H98_17325 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) C2H98_17335 ENOG4105K4H Nlp p60 protein C2H98_17340 ENOG410684U Domain of unknown function (DUF1934) C2H98_17345 ENOG4105C75 arginyL-tRNA synthetase C2H98_17370 ENOG4105DA5 (ABC) transporter C2H98_17385 ENOG4108SDH ABC, transporter C2H98_17390 ENOG4108IUW ABC transporter C2H98_17395 ENOG4107Y7X LytTR C2H98_17425 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) C2H98_17435 ENOG410812K response regulator receiver protein C2H98_17440 ENOG4105D2N Aldolase C2H98_17445 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) C2H98_17450 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) C2H98_17455 ENOG4105VFB Binds the 23S rRNA (By similarity) C2H98_17460 ENOG4107104 thymidine kinase C2H98_17470 ENOG4105C37 (CBS) domain C2H98_17475 ENOG4105C37 (CBS) domain C2H98_17480 ENOG4106SCS STAS domain C2H98_17485 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) C2H98_17490 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) C2H98_17495 ENOG4108ZXQ stage ii sporulation protein r C2H98_17500 ENOG4105DSE periplasmic solute binding protein C2H98_17505 ENOG4105DIK (ABC) transporter C2H98_17510 ENOG4105CC5 ABC transporter C2H98_17515 ENOG4105CC5 ABC transporter C2H98_17525 ENOG4105C26 Dehydrogenase C2H98_17540 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C2H98_17545 ENOG410815N Probably functions as a manganese efflux pump (By similarity) C2H98_17555 ENOG4105C8Q Methyl-accepting chemotaxis C2H98_17560 ENOG4108UIC UPF0340 protein C2H98_17565 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) C2H98_17570 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) C2H98_17575 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin C2H98_17580 ENOG41062M3 atp synthase C2H98_17585 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) C2H98_17590 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) C2H98_17600 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) C2H98_17605 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) C2H98_17610 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) C2H98_17615 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) C2H98_17620 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) C2H98_17625 ENOG4106778 Protein of unknown function (DUF1146) C2H98_17635 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) C2H98_17650 ENOG4105FRN stage II sporulation protein C2H98_17655 ENOG4105MT0 Sporulation transcriptional regulator spoiiid C2H98_17660 ENOG4105DFF Rod shape-determining protein mreb C2H98_17670 ENOG4105CGA flagellar basal-body rod protein FlgG C2H98_17700 ENOG4105C0D helicase C2H98_17705 ENOG4105KBK Zinc finger, swim domain protein C2H98_17715 ENOG4105K4H Nlp p60 protein C2H98_17725 ENOG4105KIR Thiol-disulfide oxidoreductase dcc C2H98_17730 ENOG4107RVG penicillin-binding protein C2H98_17735 ENOG4105ED1 spovr family C2H98_17740 ENOG4105J37 C2H98_17745 ENOG4105EMN RNA polymerase sigma factor C2H98_17765 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) C2H98_17770 ENOG4105K4H Nlp p60 protein C2H98_17780 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C2H98_17785 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) C2H98_17790 ENOG4105C31 Tryptophanyl-tRNA synthetase C2H98_17810 ENOG4108M15 ABC transporter C2H98_17815 ENOG4105KCT ABC transporter C2H98_17820 ENOG4105BZU Histidine kinase C2H98_17855 ENOG4108Z7F N-acetyltransferase C2H98_17865 ENOG4107SUZ Sodium/hydrogen exchanger family C2H98_17870 ENOG4105BZU Histidine kinase C2H98_17875 ENOG41090UD (LipO)protein C2H98_17880 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase C2H98_17890 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) C2H98_17895 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) C2H98_17900 ENOG4107S21 permease C2H98_17905 ENOG4105CMD Transcriptional regulator, GntR family C2H98_17910 ENOG4105I82 acetyl xylan esterase C2H98_17920 ENOG4105CS2 ec 3.2.1.21 C2H98_17925 ENOG41066F8 ROK family C2H98_17930 ENOG4105CPC Aldo Keto reductase C2H98_17940 ENOG4105YA8 Transcriptional regulator C2H98_17945 ENOG4108WC5 Alpha Beta Hydrolase Fold protein C2H98_17960 ENOG4105CK5 oxidoreductase C2H98_17970 ENOG4105C0R drug resistance transporter emrb qaca subfamily C2H98_17975 ENOG4105CW7 secretion protein, HlyD family C2H98_17980 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes C2H98_17985 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase C2H98_18000 ENOG4105KK4 UPF0060 membrane protein C2H98_18010 ENOG4105BZU Histidine kinase C2H98_18015 ENOG4105KRN Transcriptional regulator, abrb family C2H98_18030 ENOG4105CK1 PTS System C2H98_18035 ENOG4105VCP PTS System C2H98_18040 ENOG4105VZJ PTS System C2H98_18050 ENOG4105EMD TRANSCRIPTIONal C2H98_18055 ENOG4105C5Y PTS System C2H98_18070 ENOG4105CBG Sulfatase C2H98_18095 ENOG4105BZ1 (ABC) transporter C2H98_18100 ENOG4105K56 Transcriptional regulator C2H98_18135 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component C2H98_18145 ENOG4105MU9 integral membrane protein C2H98_18155 ENOG4105D64 Mechanosensitive ion channel C2H98_18160 ENOG4105HTX biosynthesis protein C2H98_18165 ENOG4107YJ4 chain length determinant protein C2H98_18170 ENOG4105D3Q Sugar transferase C2H98_18175 ENOG4108SHN Glycosyl transferase, family 2 C2H98_18180 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) C2H98_18190 ENOG4105JNK Glycosyl transferase (Group 1 C2H98_18195 ENOG4105JNK Glycosyl transferase (Group 1 C2H98_18200 ENOG4105C0K Gdp-mannose 4,6-dehydratase C2H98_18225 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) C2H98_18230 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) C2H98_18250 ENOG4105BZ1 (ABC) transporter C2H98_18255 ENOG4105CJT Mannose-1-phosphate guanylyltransferase C2H98_18265 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) C2H98_18275 ENOG4108IMY Transcriptional regulator C2H98_18285 ENOG4105HTX biosynthesis protein C2H98_18290 ENOG4107YJ4 chain length determinant protein C2H98_18295 ENOG4108RB3 Capsular polysaccharide biosynthesis protein C2H98_18300 ENOG4105D3Q Sugar transferase C2H98_18340 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase C2H98_18345 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase C2H98_18365 ENOG4106ETB IIa component C2H98_18380 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) C2H98_18415 ENOG4105ETE Transcriptional regulator (LacI family C2H98_18420 ENOG4105DJV ribulose-phosphate 3-epimerase C2H98_18425 ENOG4108RVA ribokinase C2H98_18430 ENOG4105CI1 PTS System C2H98_18460 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) C2H98_18490 ENOG4105C6K Malic enzyme C2H98_18495 ENOG4107TT2 Auxin Efflux Carrier C2H98_18505 ENOG4107RGD Major Facilitator superfamily C2H98_18515 ENOG4105CE7 Amidase, hydantoinase carbamoylase family C2H98_18520 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) C2H98_18525 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) C2H98_18565 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) C2H98_18580 ENOG4105ETE Transcriptional regulator (LacI family C2H98_18590 ENOG4108SU4 UPF0309 protein C2H98_18595 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) C2H98_18600 ENOG4105FDP GntR family transcriptional regulator C2H98_18605 ENOG4105DKQ ROK family C2H98_18615 ENOG4105F3R pts system mannose fructose sorbose family iid C2H98_18630 ENOG4105C5Y PTS System C2H98_18645 ENOG4105CBX hi0933 family C2H98_18665 ENOG4106KNT transcriptional regulator C2H98_18670 ENOG4108M26 parallel beta-helix repeat protein C2H98_18680 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain C2H98_18695 ENOG4105TRI Hydrolase C2H98_18700 ENOG4105CID antiterminator C2H98_18705 ENOG4105C5Y PTS System C2H98_18715 ENOG4108XFH Transcriptional regulator C2H98_18725 ENOG4108HE4 integrase family C2H98_18745 ENOG4105DQ5 transport system permease protein C2H98_18750 ENOG4108U1V ABC transporter, permease C2H98_18760 ENOG4105XJC Two component transcriptional regulator (Winged helix family C2H98_18795 ENOG4105J4Q Transcriptional regulator C2H98_18800 ENOG4105D7K pfkb domain protein C2H98_18805 ENOG4108UHU Aldolase C2H98_18810 ENOG4105CXK mandelate racemase muconate lactonizing C2H98_18815 ENOG4105DJB Major Facilitator Superfamily C2H98_18830 ENOG4105D4A Cell wall formation (By similarity) C2H98_18835 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component C2H98_18845 ENOG4105DZC cytosine deaminase C2H98_18850 ENOG4105DZC cytosine deaminase C2H98_18865 ENOG4106ETB IIa component C2H98_18870 ENOG4106ETB IIa component C2H98_18880 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC C2H98_18890 ENOG4107W9I Creatinine amidohydrolase C2H98_18900 ENOG4108SU4 UPF0309 protein C2H98_18915 ENOG4105E2R ROK family C2H98_18925 ENOG4105KPI PTS system sorbose subfamily IIB component C2H98_18930 ENOG4105ETZ PTS System C2H98_18935 ENOG4105F3R pts system mannose fructose sorbose family iid C2H98_18940 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) C2H98_18950 ENOG4105NAE bifunctional deaminase-reductase domain protein C2H98_18955 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C2H98_18985 ENOG4105BZU Histidine kinase C2H98_19025 ENOG4108EQA pts system C2H98_19030 ENOG4105C5I Dehydrogenase C2H98_19040 ENOG4108JQ1 Dehydrogenase C2H98_19045 ENOG4108RTU Aldolase C2H98_19050 ENOG4105C2F Histidine kinase C2H98_19055 ENOG4108NEV two component transcriptional regulator, LytTR family C2H98_19070 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component C2H98_19085 ENOG4105E5Q amino acid AbC transporter C2H98_19090 ENOG4105CDA abc transporter atp-binding protein C2H98_19095 ENOG4107TRE AP endonuclease, family 2 C2H98_19100 ENOG4108KPW sugar kinase C2H98_19105 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine C2H98_19110 ENOG4105FDP GntR family transcriptional regulator C2H98_19115 ENOG4105C26 Dehydrogenase C2H98_19125 ENOG4105C8Q Methyl-accepting chemotaxis C2H98_19135 ENOG4106IQC argininosuccinate lyase C2H98_19145 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component C2H98_19150 ENOG4105DRS transport system, permease C2H98_19155 ENOG4105DXB Major Facilitator superfamily C2H98_19165 ENOG41061AU MarR family Transcriptional regulator C2H98_19170 ENOG4107G87 m6 family metalloprotease domain protein C2H98_19200 ENOG4107SCQ Iron-containing alcohol dehydrogenase C2H98_19210 ENOG4105EAB amino acid AbC transporter C2H98_19215 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase C2H98_19220 ENOG4108XSB acetyltransferase, (GNAT) family C2H98_19225 ENOG4105EAB amino acid AbC transporter C2H98_19230 ENOG4108HW4 amino acid AbC transporter C2H98_19240 ENOG4105CH2 amidohydrolase C2H98_19245 ENOG4108PGP mmge prpd family protein C2H98_19255 ENOG4108NEV two component transcriptional regulator, LytTR family C2H98_19290 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) C2H98_19305 ENOG4105CMD Transcriptional regulator, GntR family C2H98_19325 ENOG41073R8 VanW family C2H98_19350 ENOG4105E2R ROK family C2H98_19360 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component C2H98_19365 ENOG4105DRS transport system, permease C2H98_19375 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) C2H98_19400 ENOG4108TZY GntR Family Transcriptional Regulator C2H98_19405 ENOG4105CS2 ec 3.2.1.21 C2H98_19410 ENOG4105CK1 PTS System C2H98_19420 ENOG4105VCP PTS System C2H98_19435 ENOG4107YB6 acetyltransferase, (GNAT) family C2H98_19465 ENOG4105K4I Scp-like extracellular C2H98_19470 ENOG4108KGH TRANSCRIPTIONal C2H98_19480 ENOG4105DEN Luciferase family C2H98_19500 ENOG4108W8B Beta-lactamase domain protein C2H98_19510 ENOG4105DY9 regulatoR C2H98_19515 ENOG4108KMM Diguanylate cyclase C2H98_19520 ENOG4105WH1 Two component transcriptional regulator luxr family C2H98_19525 ENOG4105EHG Permease protein C2H98_19530 ENOG4105DQ5 transport system permease protein C2H98_19540 ENOG4105CNT hydrolase family 2 C2H98_19555 ENOG4105CQ4 Transcriptional regulator C2H98_19575 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component C2H98_19580 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component C2H98_19590 ENOG4105EX0 alpha-galactosidase C2H98_19610 ENOG41067AE Membrane-bound metal-dependent hydrolase C2H98_19620 ENOG4105CPN adenine deaminase C2H98_19625 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C2H98_19630 ENOG4105F38 ABC transporter, permease C2H98_19635 ENOG4105F38 ABC transporter, permease C2H98_19655 ENOG4107QQ0 gntp family C2H98_19660 ENOG4105BZW Glycerate kinase C2H98_19665 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR C2H98_19670 ENOG4106XGU C2H98_19685 ENOG4105C5Y PTS System C2H98_19695 ENOG4107VQW regulatoR C2H98_19700 ENOG4105C4Y ABC transporter C2H98_19705 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C2H98_19715 ENOG4107Y9E nuclease C2H98_19720 ENOG4105C5Y PTS System C2H98_19725 ENOG4105CXK mandelate racemase muconate lactonizing C2H98_19730 ENOG4105FDP GntR family transcriptional regulator C2H98_19745 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component C2H98_19750 ENOG4105EK5 Glycoside hydrolase family 8 C2H98_19765 ENOG4105C2F Histidine kinase C2H98_19770 ENOG4105EQD regulatoR C2H98_19775 ENOG4108RCM Nitroreductase C2H98_19780 ENOG4105J7D transcriptional regulator C2H98_19785 ENOG4105C0R drug resistance transporter emrb qaca subfamily C2H98_19790 ENOG4105CHR reductase C2H98_19795 ENOG4105CF7 AraC family transcriptional regulator C2H98_19800 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component C2H98_19805 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component C2H98_19820 ENOG4105C2F Histidine kinase C2H98_19825 ENOG4105EQD regulatoR C2H98_19845 ENOG4105C8I hydrolase, family 38 C2H98_19850 ENOG4105EQ0 Major Facilitator superfamily C2H98_19855 ENOG4107JEE Short-chain dehydrogenase reductase Sdr C2H98_19860 ENOG4107E6A Cytochrome p-450 C2H98_19880 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) C2H98_19895 ENOG4108YRF PTS System C2H98_19900 ENOG4105DM4 PTS System C2H98_19905 ENOG4105D2N Aldolase C2H98_19910 ENOG4105D2N Aldolase C2H98_19915 ENOG4105K7K Transcriptional regulator C2H98_19930 ENOG4105EC8 Methyl-accepting chemotaxis C2H98_19940 ENOG4108S3Y transcriptional regulator C2H98_19945 ENOG4105CS2 ec 3.2.1.21 C2H98_19950 ENOG4105DPN Oligoendopeptidase f C2H98_19980 ENOG4108K4B hydrolase C2H98_19990 ENOG4105C6Y Udp-glucose 6-dehydrogenase C2H98_20005 ENOG4108TVJ Nitroreductase C2H98_20025 ENOG4105CI1 PTS System C2H98_20030 ENOG4105F8D glycoside hydrolase family 4 C2H98_20035 ENOG4108Q3X Transcriptional regulator C2H98_20060 ENOG4105BZU Histidine kinase C2H98_20065 ENOG4105C87 Aminotransferase class I and II C2H98_20080 ENOG4105C19 ABC transporter C2H98_20085 ENOG4105EWM Histidine kinase C2H98_20090 ENOG4105CJZ response regulator C2H98_20095 ENOG4105FKZ Methyl-accepting chemotaxis C2H98_20100 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) C2H98_20110 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C2H98_20115 ENOG4108UMI ABC transporter, permease C2H98_20120 ENOG4105D01 (LipO)protein C2H98_20130 ENOG4105D9N nucleoside C2H98_20150 ENOG4105FTQ Dna gyrase C2H98_20155 ENOG4105CUB amino acid C2H98_20160 ENOG4108KPW sugar kinase C2H98_20165 ENOG4105ETE Transcriptional regulator (LacI family C2H98_20170 ENOG4105CTQ phosphohexokinase C2H98_20175 ENOG4105FDP GntR family transcriptional regulator C2H98_20180 ENOG4105QEK Transcriptional regulator C2H98_20185 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) C2H98_20190 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C2H98_20195 ENOG4107YBY Hydrolase C2H98_20200 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C2H98_20215 ENOG4105ETZ PTS System C2H98_20220 ENOG4105F3R pts system mannose fructose sorbose family iid C2H98_20230 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) C2H98_20235 ENOG4108KPW sugar kinase C2H98_20240 ENOG4105DS0 Transcriptional regulator, Crp Fnr family C2H98_20245 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) C2H98_20250 ENOG4106KE4 Dehydrogenase C2H98_20255 ENOG4107SCQ Iron-containing alcohol dehydrogenase C2H98_20260 ENOG4105I1F Resistance protein C2H98_20285 ENOG4105C26 Dehydrogenase C2H98_20300 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component C2H98_20310 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) C2H98_20315 ENOG4105C0R drug resistance transporter emrb qaca subfamily C2H98_20320 ENOG4105C8Q Methyl-accepting chemotaxis C2H98_20325 ENOG4105Q95 Cupin 2, conserved barrel domain protein C2H98_20335 ENOG4105Z8H single-stranded DNA-binding protein C2H98_20345 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family C2H98_20350 ENOG4107T9C Alpha amylase catalytic region C2H98_20355 ENOG4105CMR udp-glucose 4-epimerase C2H98_20360 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase C2H98_20370 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase C2H98_20375 ENOG4107SJB teichoic acid biosynthesis C2H98_20380 ENOG4108KGH TRANSCRIPTIONal C2H98_20385 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase C2H98_20400 ENOG4105EY8 ABC transporter C2H98_20410 ENOG4105ESV Glycosyl transferase, family 4 C2H98_20415 ENOG4105JFG SpoIID LytB domain protein C2H98_20420 ENOG4108KGH TRANSCRIPTIONal C2H98_20425 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein C2H98_20430 ENOG4105BZU Histidine kinase C2H98_20435 ENOG4105WH1 Two component transcriptional regulator luxr family C2H98_20460 ENOG41081UC Inherit from COG: Competence protein C2H98_20480 ENOG4105MQ3 flagellar protein FliS C2H98_20490 ENOG4105XVJ Protein of unknown function (DUF327) C2H98_20505 ENOG4105E1Q flagellar hook-associated protein C2H98_20510 ENOG4105DTJ flagellar hook-associated protein C2H98_20515 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) C2H98_20520 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) C2H98_20535 ENOG4105C5E polysaccharide biosynthesis protein C2H98_20555 ENOG4105X1N Glycosyl transferase family 8 C2H98_20570 ENOG4107TY6 Acylneuraminate cytidylyltransferase C2H98_20580 ENOG4105CHR reductase C2H98_20595 ENOG4105D2T synthase C2H98_20600 ENOG4105C1B dTDP-glucose 4-6-dehydratase C2H98_20605 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C2H98_20615 ENOG4107RT6 flagellar hook-associated C2H98_20620 ENOG4105MQ3 flagellar protein FliS C2H98_20630 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) C2H98_20650 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C2H98_20655 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C2H98_20665 ENOG4105C3U ABC transporter C2H98_20670 ENOG4108JQ7 (ABC) transporter C2H98_20675 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) C2H98_20680 ENOG4105CAH Chromate C2H98_20685 ENOG4105FGV Chromate C2H98_20690 ENOG4107XBN GntR Family Transcriptional Regulator C2H98_20705 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C2H98_20710 ENOG4105F38 ABC transporter, permease C2H98_20715 ENOG4108I5D sulfate abc transporter C2H98_20740 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving C2H98_20780 ENOG4105CAK Cell division ATP-binding protein ftsE C2H98_20785 ENOG4105CRP Part of the ABC transporter FtsEX involved in C2H98_20790 ENOG4105DR5 peptidase C2H98_20795 ENOG4105KTU Transcriptional regulator, arsr family C2H98_20800 ENOG4105C59 p-type ATPase C2H98_20810 ENOG4105CN1 protease C2H98_20815 ENOG4105KVH Transcriptional regulator C2H98_20820 ENOG4105F27 Major Facilitator C2H98_20825 ENOG4105CV8 reductase C2H98_20835 ENOG4108YZG isomerase C2H98_20840 ENOG4105CTQ phosphohexokinase C2H98_20845 ENOG4105CV1 Transketolase (EC 2.2.1.1) C2H98_20860 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) C2H98_20865 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) C2H98_20870 ENOG4105DT3 PTS system, galactitol-specific IIc component C2H98_20875 ENOG4105CPQ Dehydrogenase C2H98_20885 ENOG4108YZG isomerase C2H98_20890 ENOG4105CTQ phosphohexokinase C2H98_20895 ENOG4105CV1 Transketolase (EC 2.2.1.1) C2H98_20915 ENOG4108JJ9 ABC, transporter C2H98_20920 ENOG4108JJ8 (ABC) transporter C2H98_20925 ENOG4108ZMQ domain protein C2H98_20930 ENOG4107EFR Flavocytochrome c C2H98_20940 ENOG4105DUN Mediates zinc uptake. May also transport other divalent cations (By similarity) C2H98_20950 ENOG4105E66 phosphoriboisomerase A C2H98_20955 ENOG4105C6K Malic enzyme C2H98_20965 ENOG4105G9B Transcriptional regulator C2H98_20970 ENOG4105CE7 Amidase, hydantoinase carbamoylase family C2H98_20975 ENOG4105C5R Aminotransferase C2H98_20980 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) C2H98_20995 ENOG4108P49 AntiSigma factor C2H98_21000 ENOG4105JVQ RNA Polymerase C2H98_21005 ENOG4105EYF MMPL domain protein C2H98_21015 ENOG4108EKI Dehydrogenase C2H98_21040 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) C2H98_21045 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) C2H98_21050 ENOG4108PY7 C2H98_21055 ENOG41086DT Membrane protein of unknown function C2H98_21060 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) C2H98_21070 ENOG4107XGZ Hydrolase C2H98_21075 ENOG4108S4C acetyltransferase C2H98_21080 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) C2H98_21085 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) C2H98_21090 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) C2H98_21095 ENOG4105ECC imidazole-glycerol-phosphate dehydratase C2H98_21100 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) C2H98_21105 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase C2H98_21110 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) C2H98_21115 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase C2H98_21130 ENOG4105C3M thioredoxin reductase C2H98_21145 ENOG4108Z4K mutator MutT protein C2H98_21150 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) C2H98_21155 ENOG4105CHW UPF0052 protein C2H98_21165 ENOG4105KRI phosphocarrier protein (HPr C2H98_21170 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) C2H98_21205 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) C2H98_21220 ENOG4105XZU Preprotein translocase, subunit SecG C2H98_21230 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) C2H98_21235 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) C2H98_21245 ENOG4105EMD TRANSCRIPTIONal C2H98_21250 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein C2H98_21260 ENOG4105DT3 PTS system, galactitol-specific IIc component C2H98_21265 ENOG4105CPQ Dehydrogenase C2H98_21275 ENOG4105C26 Dehydrogenase C2H98_21285 ENOG4108JE9 extracellular solute-binding protein family 1 C2H98_21295 ENOG4105DRS transport system, permease C2H98_21310 ENOG4105CDA abc transporter atp-binding protein C2H98_21315 ENOG4105DRP amino acid AbC transporter C2H98_21320 ENOG4105EAB amino acid AbC transporter C2H98_21335 ENOG4107XGZ Hydrolase C2H98_21355 ENOG4107ZXU DSBA oxidoreductase C2H98_21360 ENOG4108TZY GntR Family Transcriptional Regulator C2H98_21365 ENOG4107TXC Transcriptional regulator C2H98_21370 ENOG4105C0R drug resistance transporter emrb qaca subfamily C2H98_21380 ENOG4105DRR Transcriptional regulator, GntR family C2H98_21390 ENOG410681U heavy metal transport detoxification protein C2H98_21395 ENOG4105C59 p-type ATPase C2H98_21405 ENOG41075H3 AraC family transcriptional regulator C2H98_21415 ENOG4107YY3 extracellular solute-binding protein family 1 C2H98_21420 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component C2H98_21425 ENOG4105DRS transport system, permease C2H98_21440 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) C2H98_21445 ENOG4105FF2 Type I DHQase C2H98_21450 ENOG4105C26 Dehydrogenase C2H98_21510 ENOG4107MMM Anti-sigma-factor antagonist C2H98_21530 ENOG4105C2F Histidine kinase C2H98_21535 ENOG4105EQD regulatoR C2H98_21540 ENOG410769Z extracellular solute-binding protein family 1 C2H98_21545 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component C2H98_21550 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component C2H98_21555 ENOG4105F5H Glycosyl Hydrolase Family 88 C2H98_21570 ENOG4105ETE Transcriptional regulator (LacI family C2H98_21575 ENOG4105C5H ABC transporter C2H98_21600 ENOG41080HJ 6-phospho 3-hexuloisomerase C2H98_21605 ENOG4108VA3 3-hexulose-6-phosphate synthase C2H98_21610 ENOG4105KVH Transcriptional regulator C2H98_21615 ENOG4105FKQ transcriptional regulator C2H98_21630 ENOG4105KA0 thioesterase Superfamily protein C2H98_21635 ENOG41067TZ transcriptional regulator, MarR family C2H98_21640 ENOG4105EYF MMPL domain protein C2H98_21645 ENOG4106F5Q Membrane C2H98_21650 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) C2H98_21670 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C2H98_21675 ENOG4105C28 cystathionine C2H98_21685 ENOG4108007 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation C2H98_21690 ENOG4105K63 Thioredoxin C2H98_21695 ENOG4105BZ1 (ABC) transporter C2H98_21700 ENOG4105BZ1 (ABC) transporter C2H98_21725 ENOG4105DRP amino acid AbC transporter C2H98_21730 ENOG4105CDA abc transporter atp-binding protein C2H98_21740 ENOG4105C8Q Methyl-accepting chemotaxis C2H98_21775 ENOG4105C1G acyl-Coa dehydrogenase C2H98_21780 ENOG41080E8 Transcriptional regulator, Spx MgsR family C2H98_21785 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) C2H98_21805 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C2H98_21810 ENOG4108UMI ABC transporter, permease C2H98_21815 ENOG4105D01 (LipO)protein C2H98_21820 ENOG4105C3K feS assembly ATPase SufC C2H98_21825 ENOG4105JRK feS assembly protein SufD C2H98_21830 ENOG4105C9B Cysteine desulfurase C2H98_21835 ENOG4108UNV SUF system FeS assembly protein, NifU family C2H98_21840 ENOG4105DIW FeS assembly protein SUFB C2H98_21845 ENOG4105DKQ ROK family C2H98_21855 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase C2H98_21860 ENOG4108UW5 maltose o-acetyltransferase C2H98_21865 ENOG4108HCJ Hydrolase C2H98_21870 ENOG4105J4Q Transcriptional regulator C2H98_21885 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) C2H98_21890 ENOG4105CHR reductase C2H98_21895 ENOG4105I3N Conserved Protein C2H98_21900 ENOG4107R8B 5'-nucleotidase C2H98_21905 ENOG4105KZD Domain of unknown function (DUF1805) C2H98_21910 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase C2H98_21915 ENOG4105FAA peptidase M23 C2H98_21920 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) C2H98_21925 ENOG4105MMD transcriptional regulator C2H98_21930 ENOG4105BZU Histidine kinase C2H98_21940 ENOG4105D4U had-superfamily hydrolase, subfamily iia C2H98_21945 ENOG4108W5N phosphatidylglycerophosphatase a C2H98_21955 ENOG4105D6E homoserine dehydrogenase C2H98_21960 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) C2H98_21965 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) C2H98_21970 ENOG41083MR nifu domain-containing protein C2H98_21985 ENOG4105ZKE UPF0349 protein C2H98_21995 ENOG4108YX9 iron--sulfur cluster insertion protein erpA C2H98_22000 ENOG4105CAY ferredoxin--nadp reductase C2H98_22005 ENOG41069ER domain protein C2H98_22015 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) C2H98_22030 ENOG4105CHR reductase C2H98_22060 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) C2H98_22080 ENOG4105KJM monovalent cation h antiporter subunit g C2H98_22090 ENOG4105SC1 monovalent cation H antiporter subunit E C2H98_22095 ENOG4108JPZ Monovalent cation H antiporter subunit D C2H98_22100 ENOG4108ZE9 Monovalent cation H antiporter subunit C C2H98_22105 ENOG4105HC0 Na H antiporter C2H98_22110 ENOG4105D65 subunit l C2H98_22130 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C2H98_22135 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) C2H98_22145 ENOG4105D01 (LipO)protein C2H98_22150 ENOG4108UMI ABC transporter, permease C2H98_22155 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C2H98_22165 ENOG4108ZB6 transcriptional regulator AsnC family C2H98_22170 ENOG4105CHM Aminotransferase C2H98_22180 ENOG4105C8Y Acetylornithine aminotransferase C2H98_22185 ENOG4105WG9 Conserved Protein C2H98_22190 ENOG4107QW4 alcohol dehydrogenase C2H98_22205 ENOG4107PBV potassium channel C2H98_22210 ENOG41067SE Tetr family transcriptional regulator C2H98_22215 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) C2H98_22220 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) C2H98_22225 ENOG4108UX3 '-nucleotidase C2H98_22230 ENOG4105FGV Chromate C2H98_22235 ENOG4105CAH Chromate C2H98_22250 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase C2H98_22255 ENOG4105QVS general stress protein C2H98_22265 ENOG4108DBC nitroreductase C2H98_22270 ENOG41061TZ Short-chain dehydrogenase reductase Sdr C2H98_22275 ENOG4105CIS alcohol dehydrogenase C2H98_22280 ENOG41067CD Small, acid-soluble spore protein Tlp C2H98_22290 ENOG4105BZU Histidine kinase C2H98_22310 ENOG4105KT7 mgtC SapB transporter C2H98_22445 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) C2H98_22455 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) C2H98_22470 ENOG4105E4F Isochorismate synthase C2H98_22475 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) C2H98_22480 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) C2H98_22485 ENOG4108IPT Naphthoate synthase C2H98_22505 ENOG4108V2W Carbonate dehydratase C2H98_22510 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) C2H98_22520 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) C2H98_22550 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP C2H98_22555 ENOG4105CAQ asparagine synthetase C2H98_22565 ENOG4105E8V Alpha Beta Hydrolase Fold protein C2H98_22580 ENOG4105N5T Radical SAM Protein C2H98_22595 ENOG410605W Major Facilitator C2H98_22600 ENOG4107TB6 phosphoglycerate mutase C2H98_22605 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C2H98_22610 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) C2H98_22620 ENOG4105C8T Leucyl-tRNA synthetase C2H98_22625 ENOG41085GJ domain protein C2H98_22635 ENOG4105CBX hi0933 family C2H98_22650 ENOG4105YW5 deoR family transcriptional regulator C2H98_22655 ENOG4105E09 nadh pyrophosphatase C2H98_22660 ENOG4107QSE Dipeptidase C2H98_22670 ENOG4107F58 2'-5' rna ligase C2H98_22680 ENOG4108IUM Glycogen debranching enzyme C2H98_22685 ENOG4108V15 phosphotransferase enzyme family C2H98_22695 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) C2H98_22720 ENOG4108NKM UPF0354 protein C2H98_22730 ENOG4105DFU Cell wall formation (By similarity) C2H98_22735 ENOG4105C88 aminopeptidase C2H98_22755 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) C2H98_22760 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase C2H98_22765 ENOG4105ETE Transcriptional regulator (LacI family C2H98_22785 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) C2H98_22790 ENOG4105BZU Histidine kinase C2H98_22800 ENOG4105U5Y Transcriptional regulator C2H98_22805 ENOG4108W76 histidinol phosphate phosphatase hisj family C2H98_22810 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) C2H98_22820 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) C2H98_22830 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C2H98_22835 ENOG4105EFZ amidohydrolase C2H98_22840 ENOG4105FR1 rard protein C2H98_22845 ENOG4105D07 Signal peptide peptidase, SppA C2H98_22850 ENOG4105VK3 rdd domain containing protein C2H98_22860 ENOG4105KBJ sporulation protein ytfj C2H98_22865 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) C2H98_22875 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) C2H98_22885 ENOG4105EEM helicase C2H98_22890 ENOG4105EPU Molybdenum cofactor synthesis domain protein C2H98_22895 ENOG4105CDH Citrulline--aspartate ligase C2H98_22900 ENOG4105CH7 arginosuccinase C2H98_22905 ENOG4107YZX Universal stress protein C2H98_22915 ENOG4105DC7 peptidase M24 C2H98_22930 ENOG4105SFS phosphoesterase RecJ domain protein C2H98_22940 ENOG4105VV2 C2H98_22945 ENOG4105C0B DNA polymerase III (alpha subunit) C2H98_22950 ENOG4107YCY Transcriptional regulator C2H98_22960 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) C2H98_22970 ENOG4105CA9 Pyruvate kinase C2H98_22975 ENOG4105FS0 cytoplasmic membrane protein C2H98_22980 ENOG4105C2F Histidine kinase C2H98_22985 ENOG41075H3 AraC family transcriptional regulator C2H98_22990 ENOG4105XN3 extracellular solute-binding protein family 1 C2H98_22995 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component C2H98_23000 ENOG4105I1K ABC transporter C2H98_23005 ENOG4105MU9 integral membrane protein C2H98_23010 ENOG4107QNR UPF0135 protein C2H98_23020 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component C2H98_23035 ENOG4105DMW Dehydrogenase reductase C2H98_23080 ENOG4108REF Sporulation integral membrane protein ytvi C2H98_23085 ENOG4108VMM UPF0756 membrane protein C2H98_23090 ENOG4105BZN citrate synthase C2H98_23095 ENOG4108HMX isocitrate dehydrogenase (NADP) C2H98_23100 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) C2H98_23105 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C2H98_23110 ENOG4105BZU Histidine kinase C2H98_23115 ENOG4105C2M dna polymerase I C2H98_23120 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) C2H98_23135 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) C2H98_23155 ENOG4108TDW sporulation protein YtxC C2H98_23160 ENOG4105C22 threonyL-tRNA synthetase C2H98_23165 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) C2H98_23175 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) C2H98_23180 ENOG410696E Membrane C2H98_23195 ENOG4105CN9 Peptidase m42 family protein C2H98_23200 ENOG4105C02 permease C2H98_23205 ENOG4105E2R ROK family C2H98_23210 ENOG4105C93 Xylose Isomerase C2H98_23215 ENOG4105CMG Carbohydrate kinase C2H98_23220 ENOG41067MF small acid-soluble spore protein C2H98_23225 ENOG4108RWN rrna methyltransferase C2H98_23230 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) C2H98_23235 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) C2H98_23250 ENOG4105DRS transport system, permease C2H98_23255 ENOG4105ETE Transcriptional regulator (LacI family C2H98_23260 ENOG41066F8 ROK family C2H98_23265 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) C2H98_23275 ENOG4105DCG PHP domain protein C2H98_23290 ENOG4105CEY Amp-dependent synthetase and ligase C2H98_23295 ENOG4105BZJ Electron transfer flavoprotein C2H98_23300 ENOG4105C10 Electron transfer flavoprotein C2H98_23305 ENOG4105K63 Thioredoxin C2H98_23325 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit C2H98_23335 ENOG4105E33 succinate dehydrogenase C2H98_23345 ENOG4105PFC Transcriptional regulator C2H98_23350 ENOG41067TZ transcriptional regulator, MarR family C2H98_23355 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) C2H98_23360 ENOG4108XJQ germination protein C2H98_23370 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) C2H98_23375 ENOG4105M59 Phosphodiesterase, mj0936 family C2H98_23530 ENOG4105C2M dna polymerase I C2H98_23555 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) C2H98_23565 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) C2H98_23570 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C2H98_23575 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C2H98_23590 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) C2H98_23600 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) C2H98_23615 ENOG4105DVF Cytosine-specific methyltransferase C2H98_23760 ENOG4107X35 defense response to bacterium C2H98_23815 ENOG4107KM7 Heat induced stress protein YflT C2H98_23825 ENOG4105C7K acetolactate synthase C2H98_23830 ENOG4108ZP8 Acetolactate synthase small subunit C2H98_23835 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase C2H98_23840 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) C2H98_23845 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) C2H98_23850 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C2H98_23855 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C2H98_23865 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation C2H98_23870 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) C2H98_23875 ENOG4108IUQ atp-dependent protease C2H98_23880 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) C2H98_23885 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) C2H98_23895 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) C2H98_23905 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) C2H98_23915 ENOG4105D52 delta-aminolevulinic acid dehydratase C2H98_23920 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase C2H98_23925 ENOG4105E2Y ABC, transporter C2H98_23930 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component C2H98_23940 ENOG4107BJW polysaccharide deacetylase C2H98_23945 ENOG41068KH stage VI sporulation protein D C2H98_23945 ENOG41068KH stage VI sporulation protein D C2H98_23950 ENOG4106AR7 Spore coat protein C2H98_23955 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) C2H98_23960 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase C2H98_23965 ENOG4105BZU Histidine kinase C2H98_24005 ENOG4107QHF type ii secretion system protein e C2H98_24010 ENOG4105CZX twitching motility protein C2H98_24025 ENOG4106A3R peptidase C2H98_24055 ENOG4108Z03 MAF-like protein C2H98_24060 ENOG4105W5Q DNA repair protein (RadC C2H98_24065 ENOG4105DFF Rod shape-determining protein mreb C2H98_24070 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) C2H98_24075 ENOG4105YHC Rod shape-determining protein MreD C2H98_24080 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) C2H98_24085 ENOG4107QMS site-determining protein C2H98_24100 ENOG4105C03 ribonuclease C2H98_24105 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) C2H98_24110 ENOG4105X36 (ribosomal) protein C2H98_24115 ENOG4105K46 50S ribosomal protein l27 C2H98_24125 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control C2H98_24130 ENOG41090I5 UPF0735 ACT domain-containing protein C2H98_24135 ENOG4105CQC Prephenate dehydratase C2H98_24180 ENOG41061AI Protein of unknown function (DUF2905) C2H98_24185 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) C2H98_24195 ENOG4105VIE preprotein translocase, subunit YajC C2H98_24200 ENOG4105NAP C2H98_24205 ENOG4108QG2 Membrane C2H98_24210 ENOG4105CKP Polysaccharide Biosynthesis Protein C2H98_24220 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C2H98_24225 ENOG41067VP Protein of unknown function (DUF1049) C2H98_24230 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) C2H98_24235 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) C2H98_24240 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) C2H98_24250 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C2H98_24255 ENOG4105CUT histidyl-tRNA synthetase C2H98_24260 ENOG4105C9M aspartyl-trna synthetase C2H98_24265 ENOG4105CUZ uba thif-type nad fad binding protein C2H98_24275 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family C2H98_24280 ENOG4105CZV ABC transporter C2H98_24285 ENOG4105CJ1 ABC, transporter C2H98_24290 ENOG4108TU7 Inherit from COG: (ABC) transporter C2H98_24295 ENOG4105D1H recombination factor protein RarA C2H98_24310 ENOG4105EG2 ABC transporter, permease C2H98_24320 ENOG4107VQW regulatoR C2H98_24325 ENOG4105DTQ mandelate racemase muconate lactonizing C2H98_24350 ENOG4105C3J Cysteine desulfurase C2H98_24355 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) C2H98_24365 ENOG4105C7H Helicase, RecD TraA family C2H98_24370 ENOG41060CR C2H98_24380 ENOG4105C02 permease C2H98_24385 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) C2H98_24390 ENOG4105VBH UPF0297 protein C2H98_24400 ENOG4105VPH UPF0473 protein C2H98_24405 ENOG4105HHA aminodeoxychorismate lyase C2H98_24410 ENOG4108VQJ O-methyltransferase C2H98_24415 ENOG4105XYU peptidase (U32 family) C2H98_24420 ENOG4105CFP Peptidase U32 C2H98_24425 ENOG4105DBI uridine monophosphokinase C2H98_24430 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) C2H98_24435 ENOG4107XRG penicillin-binding protein C2H98_24450 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) C2H98_24455 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) C2H98_24465 ENOG4105C28 cystathionine C2H98_24475 ENOG4107Y5K Resolvase C2H98_24480 ENOG4105DBI uridine monophosphokinase C2H98_24485 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) C2H98_24500 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) C2H98_24545 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 C2H98_24560 ENOG41068K0 YCII-related domain C2H98_24630 ENOG4105F0V Cell wall hydrolase C2H98_24670 ENOG41060YP C2H98_24700 ENOG4107Y5K Resolvase C2H98_24720 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C2H98_24735 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase C2H98_24740 ENOG4105DJ4 phosphatidylserine decarboxylase C2H98_24750 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase C2H98_24755 ENOG4105CQW ribosome biogenesis GTPase YqeH C2H98_24765 ENOG410812S Rna-binding protein C2H98_24770 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) C2H98_24775 ENOG4108WF2 Metal Dependent Phosphohydrolase C2H98_24780 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) C2H98_24785 ENOG4105DXX methyltransferase C2H98_24795 ENOG4105KQC Competence protein C2H98_24800 ENOG4108UK2 deaminase C2H98_24805 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 C2H98_24810 ENOG4105TQK DNA polymerase iii, delta' subunit C2H98_24815 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) C2H98_24820 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) C2H98_24830 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) C2H98_24835 ENOG4105CSA Coproporphyrinogen iii oxidase C2H98_24840 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) C2H98_24845 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ C2H98_24850 ENOG4105CFG Acts as a chaperone (By similarity) C2H98_24855 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) C2H98_24860 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) C2H98_24865 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) C2H98_24870 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) C2H98_24875 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) C2H98_24880 ENOG4106HBX Transcriptional Regulator AraC Family C2H98_24885 ENOG4105BZ1 (ABC) transporter C2H98_24890 ENOG4105BZ1 (ABC) transporter C2H98_24905 ENOG4105KTH gatB Yqey C2H98_24910 ENOG4105F7J membrane-bound serine protease C2H98_24915 ENOG4105DI5 UPF0365 protein C2H98_24925 ENOG41068P3 sporulation protein YqfC C2H98_24935 ENOG4105C9A Phoh family C2H98_24940 ENOG4105CTJ Metal Dependent Phosphohydrolase C2H98_24945 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) C2H98_24950 ENOG4107YR5 Diacylglycerol kinase C2H98_24955 ENOG4105KG3 cytidine deaminase C2H98_24960 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) C2H98_24970 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) C2H98_24980 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit C2H98_24985 ENOG4105C38 Glycyl-tRNA synthetase beta subunit C2H98_24995 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) C2H98_25000 ENOG4108UPT UPF0178 protein C2H98_25005 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) C2H98_25010 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C2H98_25025 ENOG4105EGD dinuclear metal center protein, YbgI family C2H98_25030 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) C2H98_25045 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) C2H98_25055 ENOG4105N80 Ferric uptake regulator, Fur family C2H98_25060 ENOG4108U5J '-nucleotidase C2H98_25070 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) C2H98_25080 ENOG4105C8Q Methyl-accepting chemotaxis C2H98_25090 ENOG4105SXS Protein of unknown function (DUF456) C2H98_25095 ENOG4107V6Q Cyclic nucleotide-binding domain C2H98_25110 ENOG4107RF6 penicillin-binding protein C2H98_25115 ENOG4107RF6 penicillin-binding protein C2H98_25120 ENOG4105CVA phosphate C2H98_25125 ENOG4105C8U phosphate abc transporter C2H98_25130 ENOG4105E2Z phosphate ABC transporter (Permease C2H98_25135 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) C2H98_25140 ENOG4108UTW Plays a role in the regulation of phosphate uptake C2H98_25170 ENOG4105WDJ 50S ribosomal protein L33 C2H98_25175 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase C2H98_25195 ENOG4107ZXI Rhomboid family C2H98_25210 ENOG4105DKQ ROK family C2H98_25215 ENOG4105E0M Sulfatase C2H98_25235 ENOG4105C5X domain protein C2H98_25245 ENOG4105H3G oxidoreductase C2H98_25250 ENOG4105PGM cation diffusion facilitator family transporter C2H98_25270 ENOG4106855 Competence protein C2H98_25305 ENOG4105C0D helicase C2H98_25310 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) C2H98_25315 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor C2H98_25320 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor C2H98_25325 ENOG4105WZW rhodanese family C2H98_25330 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity)