locus-tag	class	description
C2H98_00040	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2H98_00050	COG3872	metal-dependent enzyme
C2H98_00060	COG0006	proline dipeptidase activity
C2H98_00065	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C2H98_00080	COG2972	Histidine kinase
C2H98_00085	COG2207	Transcriptional regulator
C2H98_00085	COG4753	response regulator
C2H98_00100	COG4209	transmembrane transport
C2H98_00105	COG0395	ABC-type sugar transport system, permease component
C2H98_00120	COG1501	Belongs to the glycosyl hydrolase 31 family
C2H98_00125	COG2723	6-phospho-beta-galactosidase activity
C2H98_00135	COG1785	Belongs to the alkaline phosphatase family
C2H98_00155	COG3854	ATPases associated with a variety of cellular activities
C2H98_00195	COG0511	ligase activity, forming carbon-carbon bonds
C2H98_00200	COG0439	Biotin carboxylase
C2H98_00205	COG1302	Protein conserved in bacteria
C2H98_00220	COG1722	exodeoxyribonuclease VII activity
C2H98_00225	COG0142	geranyltranstransferase activity
C2H98_00230	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C2H98_00235	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C2H98_00240	COG1438	arginine binding
C2H98_00245	COG0497	DNA recombination
C2H98_00250	COG0750	zinc metalloprotease
C2H98_00255	COG1575	Belongs to the MenA family. Type 1 subfamily
C2H98_00260	COG0745	RESPONSE REGULATOR receiver
C2H98_00265	COG4974	Belongs to the 'phage' integrase family
C2H98_00325	COG0584	glycerophosphoryl diester phosphodiesterase
C2H98_00330	COG3290	protein histidine kinase activity
C2H98_00330	COG3829	transcription factor binding
C2H98_00335	COG3426	butyrate kinase activity
C2H98_00340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2H98_00345	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2H98_00350	COG0022	dehydrogenase e1 component
C2H98_00355	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2H98_00365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H98_00370	COG0765	amino acid transport
C2H98_00375	COG1126	abc transporter atp-binding protein
C2H98_00380	COG1376	ErfK ybiS ycfS ynhG family protein
C2H98_00385	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2H98_00395	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2H98_00400	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C2H98_00405	COG1408	metallophosphoesterase
C2H98_00410	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C2H98_00415	COG1234	tRNA 3'-trailer cleavage
C2H98_00420	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2H98_00430	COG0300	oxidoreductase activity
C2H98_00440	COG1846	Transcriptional regulator
C2H98_00445	COG2814	Major facilitator Superfamily
C2H98_00450	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2H98_00495	COG0640	Transcriptional regulator
C2H98_00500	COG2814	Major facilitator Superfamily
C2H98_00505	COG1073	alpha beta
C2H98_00510	COG1764	response to oxidative stress
C2H98_00540	COG3620	sequence-specific DNA binding
C2H98_00545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H98_00570	COG1595	DNA-templated transcription, initiation
C2H98_00590	COG2186	Transcriptional regulator
C2H98_00595	COG4948	Mandelate Racemase Muconate Lactonizing
C2H98_00600	COG1063	alcohol dehydrogenase
C2H98_00605	COG1028	Short-chain dehydrogenase reductase Sdr
C2H98_00610	COG2271	Major facilitator Superfamily
C2H98_00645	COG1078	dGTPase activity
C2H98_00650	COG0346	lactoylglutathione lyase activity
C2H98_00655	COG0456	acetyltransferase
C2H98_00660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H98_00680	COG0667	Aldo Keto reductase
C2H98_00695	COG1379	DNA repair
C2H98_00705	COG1300	Membrane
C2H98_00710	COG0735	belongs to the Fur family
C2H98_00720	COG4974	Belongs to the 'phage' integrase family
C2H98_00795	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C2H98_00815	COG1595	DNA-templated transcription, initiation
C2H98_00820	COG0024	Methionine aminopeptidase
C2H98_00825	COG1686	Belongs to the peptidase S11 family
C2H98_00835	COG2172	sigma factor antagonist activity
C2H98_00860	COG0697	spore germination
C2H98_00870	COG4086	secreted protein
C2H98_00880	COG1547	Domain of unknown function (DUF309)
C2H98_00885	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C2H98_00890	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C2H98_00895	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2H98_00900	COG1686	Belongs to the peptidase S11 family
C2H98_00905	COG2715	membrane protein required for spore maturation
C2H98_00910	COG0700	Nucleoside recognition
C2H98_00915	COG1187	pseudouridine synthase activity
C2H98_00920	COG0745	RESPONSE REGULATOR receiver
C2H98_00925	COG5002	protein histidine kinase activity
C2H98_00930	COG1595	DNA-templated transcription, initiation
C2H98_00945	COG0739	heme binding
C2H98_00950	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C2H98_00955	COG1141	Ferredoxin
C2H98_00965	COG0514	ATP-dependent DNA helicase (RecQ)
C2H98_00970	COG1266	CAAX protease self-immunity
C2H98_00985	COG3546	catalase activity
C2H98_01000	COG1408	metallophosphoesterase
C2H98_01005	COG4862	establishment of competence for transformation
C2H98_01010	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2H98_01015	COG0492	ferredoxin-NADP+ reductase activity
C2H98_01020	COG2339	peptidase activity
C2H98_01025	COG3409	Peptidoglycan-binding domain 1 protein
C2H98_01025	COG3773	Cell wall hydrolase
C2H98_01030	COG2959	enzyme of heme biosynthesis
C2H98_01045	COG0539	negative regulation of cytoplasmic translation
C2H98_01070	COG1160	GTP binding
C2H98_01075	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C2H98_01080	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C2H98_01085	COG0776	regulation of translation
C2H98_01090	COG0142	geranyltranstransferase activity
C2H98_01095	COG2226	methyltransferase
C2H98_01100	COG0142	geranyltranstransferase activity
C2H98_01110	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C2H98_01120	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C2H98_01125	COG4401	Chorismate mutase type I
C2H98_01130	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C2H98_01135	COG0287	Prephenate dehydrogenase
C2H98_01140	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C2H98_01150	COG0457	Tetratricopeptide repeat
C2H98_01155	COG5582	Belongs to the UPF0302 family
C2H98_01160	COG4347	Protein of unknown function (DUF1405)
C2H98_01170	COG2738	Putative neutral zinc metallopeptidase
C2H98_01175	COG2223	nitrite transmembrane transporter activity
C2H98_01185	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H98_01190	COG1694	Mazg nucleotide pyrophosphohydrolase
C2H98_01195	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C2H98_01200	COG1803	Methylglyoxal synthase
C2H98_01205	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2H98_01210	COG0438	transferase activity, transferring glycosyl groups
C2H98_01215	COG0617	tRNA 3'-terminal CCA addition
C2H98_01230	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C2H98_01235	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C2H98_01250	COG0436	Aminotransferase
C2H98_01255	COG0017	Asparaginyl-tRNA synthetase
C2H98_01260	COG3935	DnaD domain protein
C2H98_01265	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2H98_01275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2H98_01275	COG4499	WXG100 protein secretion system (Wss), protein YukC
C2H98_01280	COG3331	DNA recombination
C2H98_01310	COG0071	Belongs to the small heat shock protein (HSP20) family
C2H98_01315	COG2267	carboxylic ester hydrolase activity
C2H98_01320	COG1111	helicase
C2H98_01320	COG1205	dead DEAH box helicase
C2H98_01325	COG3359	exonuclease
C2H98_01335	COG4474	Belongs to the UPF0398 family
C2H98_01350	COG0116	Belongs to the methyltransferase superfamily
C2H98_01355	COG1199	ATP-dependent helicase activity
C2H98_01360	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C2H98_01370	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C2H98_01385	COG1131	(ABC) transporter
C2H98_01395	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2H98_01405	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
C2H98_01415	COG0328	RNA-DNA hybrid ribonuclease activity
C2H98_01420	COG0328	RNA-DNA hybrid ribonuclease activity
C2H98_01430	COG1278	Cold shock
C2H98_01445	COG4129	membrane
C2H98_01470	COG0551	DNA topoisomerase type I activity
C2H98_01470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2H98_01475	COG1321	iron dependent repressor
C2H98_01490	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C2H98_01495	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C2H98_01505	COG0386	Belongs to the glutathione peroxidase family
C2H98_01525	COG1418	mRNA catabolic process
C2H98_01530	COG0488	(ABC) transporter
C2H98_01535	COG1413	lyase activity
C2H98_01545	COG2521	methyltransferase
C2H98_01545	COG2136	Putative SAM-dependent methyltransferase
C2H98_01555	COG2310	stress, protein
C2H98_01560	COG0861	Integral membrane protein TerC family
C2H98_01575	COG1358	cellular component organization or biogenesis
C2H98_01595	COG3853	Toxic anion resistance protein (TelA)
C2H98_01600	COG2310	stress, protein
C2H98_01605	COG2310	stress, protein
C2H98_01620	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C2H98_01640	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H98_01645	COG3715	PTS system
C2H98_01650	COG3716	PTS system mannose fructose sorbose family IID component
C2H98_01655	COG1272	protein, Hemolysin III
C2H98_01660	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2H98_01665	COG1307	EDD domain protein, DegV family
C2H98_01670	COG5002	protein histidine kinase activity
C2H98_01675	COG2755	lipolytic protein G-D-S-L family
C2H98_01700	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2H98_01710	COG4479	Belongs to the UPF0346 family
C2H98_01730	COG1876	peptidase activity
C2H98_01735	COG0793	Belongs to the peptidase S41A family
C2H98_01735	COG3409	Peptidoglycan-binding domain 1 protein
C2H98_01740	COG0523	cobalamin synthesis protein
C2H98_01755	COG2340	Cysteine-rich secretory protein family
C2H98_01775	COG0534	Mate efflux family protein
C2H98_01780	COG0640	Transcriptional regulator
C2H98_01785	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2H98_01815	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C2H98_01820	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C2H98_01830	COG1793	dna ligase
C2H98_01830	COG3285	dna ligase
C2H98_01835	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C2H98_01840	COG0671	phosphoesterase, PA-phosphatase related
C2H98_01845	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
C2H98_01850	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2H98_01860	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2H98_01865	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C2H98_01870	COG1278	Cold shock
C2H98_01875	COG0513	Belongs to the DEAD box helicase family
C2H98_01880	COG1278	Cold shock
C2H98_01900	COG1346	cytolysis
C2H98_01910	COG0583	DNA-binding transcription factor activity
C2H98_01930	COG0726	polysaccharide deacetylase
C2H98_01980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H98_01985	COG0406	alpha-ribazole phosphatase activity
C2H98_01995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H98_02015	COG0586	Pfam SNARE associated Golgi protein
C2H98_02030	COG4377	Putative membrane peptidase family (DUF2324)
C2H98_02035	COG1690	Belongs to the RtcB family
C2H98_02075	COG1115	amino acid carrier protein
C2H98_02080	COG3708	Transcriptional regulator
C2H98_02080	COG2207	Transcriptional regulator
C2H98_02090	COG0384	phenazine biosynthesis protein PhzF
C2H98_02110	COG2733	membrane
C2H98_02140	COG1357	PFAM Pentapeptide repeats (8 copies)
C2H98_02155	COG1595	DNA-templated transcription, initiation
C2H98_02185	COG5646	InterPro IPR014922
C2H98_02190	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
C2H98_02205	COG3655	Transcriptional regulator
C2H98_02210	COG3739	integral membrane protein
C2H98_02295	COG5444	nuclease activity
C2H98_02405	COG5444	nuclease activity
C2H98_02495	COG2849	repeat protein
C2H98_02540	COG0523	cobalamin synthesis protein
C2H98_02545	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C2H98_02550	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C2H98_02560	COG1609	Transcriptional regulator
C2H98_02570	COG1263	PTS System
C2H98_02570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H98_02575	COG1737	Transcriptional regulator
C2H98_02580	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C2H98_02615	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2H98_02625	COG0840	transmembrane signaling receptor activity
C2H98_02630	COG0523	cobalamin synthesis protein
C2H98_02635	COG0701	Predicted permease
C2H98_02650	COG0351	phosphomethylpyrimidine kinase
C2H98_02665	COG0004	ammonium transporteR
C2H98_02675	COG2176	DNA-directed DNA polymerase activity
C2H98_02690	COG1349	DNA-binding transcription factor activity
C2H98_02695	COG1105	Belongs to the carbohydrate kinase PfkB family
C2H98_02700	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H98_02700	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H98_02700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H98_02705	COG2814	Major facilitator Superfamily
C2H98_02710	COG2258	MOSC domain
C2H98_02715	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2H98_02720	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2H98_02720	COG0512	Glutamine amidotransferase of anthranilate synthase
C2H98_02750	COG0583	DNA-binding transcription factor activity
C2H98_02755	COG1132	(ABC) transporter
C2H98_02760	COG0697	spore germination
C2H98_02765	COG0561	phosphatase activity
C2H98_02770	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C2H98_02775	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C2H98_02785	COG1695	Transcriptional regulator
C2H98_02820	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C2H98_02835	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H98_02850	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C2H98_02855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H98_02865	COG0561	phosphatase activity
C2H98_02875	COG0737	Belongs to the 5'-nucleotidase family
C2H98_02880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H98_02895	COG1276	copper resistance
C2H98_02895	COG2372	response to copper ion
C2H98_02900	COG1268	BioY protein
C2H98_02925	COG2814	Major facilitator Superfamily
C2H98_02930	COG1404	Belongs to the peptidase S8 family
C2H98_02935	COG1482	cell wall glycoprotein biosynthetic process
C2H98_02950	COG1349	DNA-binding transcription factor activity
C2H98_02955	COG0561	phosphatase activity
C2H98_02960	COG0204	Acyl-transferase
C2H98_02965	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2H98_02970	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H98_02985	COG1309	transcriptional regulator
C2H98_02995	COG3859	Proton-coupled thiamine transporter YuaJ
C2H98_03010	COG3858	chitin binding
C2H98_03015	COG0840	transmembrane signaling receptor activity
C2H98_03020	COG1832	CoA-binding protein
C2H98_03025	COG0187	DNA topoisomerase II activity
C2H98_03030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C2H98_03075	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2H98_03080	COG1131	(ABC) transporter
C2H98_03085	COG4473	ABC transporter
C2H98_03090	COG1051	belongs to the nudix hydrolase family
C2H98_03105	COG4977	sequence-specific DNA binding
C2H98_03110	COG1349	DNA-binding transcription factor activity
C2H98_03115	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2H98_03120	COG0730	response to heat
C2H98_03125	COG0583	DNA-binding transcription factor activity
C2H98_03140	COG1621	beta-fructofuranosidase activity
C2H98_03145	COG1609	Transcriptional regulator
C2H98_03150	COG0492	ferredoxin-NADP+ reductase activity
C2H98_03165	COG0701	Predicted permease
C2H98_03170	COG3689	TIGRFAM TIGR03943 family protein
C2H98_03215	COG1280	lysine exporter protein (LysE YggA)
C2H98_03220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H98_03225	COG0326	Molecular chaperone. Has ATPase activity
C2H98_03230	COG0753	catalase activity
C2H98_03235	COG1042	CoA-binding domain protein
C2H98_03235	COG0045	succinate-CoA ligase (ADP-forming) activity
C2H98_03235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H98_03255	COG0531	amino acid
C2H98_03265	COG0024	Methionine aminopeptidase
C2H98_03270	COG1280	lysine exporter protein (LysE YggA)
C2H98_03280	COG0840	transmembrane signaling receptor activity
C2H98_03290	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C2H98_03295	COG2066	Belongs to the glutaminase family
C2H98_03305	COG1966	Carbon starvation protein
C2H98_03310	COG3279	Response regulator of the LytR AlgR family
C2H98_03315	COG3275	phosphorelay sensor kinase activity
C2H98_03320	COG0328	RNA-DNA hybrid ribonuclease activity
C2H98_03320	COG3341	Caulimovirus viroplasmin
C2H98_03330	COG2027	D-alanyl-D-alanine carboxypeptidase
C2H98_03340	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2H98_03345	COG1733	regulation of RNA biosynthetic process
C2H98_03375	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H98_03395	COG0561	phosphatase activity
C2H98_03400	COG0346	lactoylglutathione lyase activity
C2H98_03405	COG0708	Exodeoxyribonuclease III
C2H98_03410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H98_03415	COG0307	riboflavin synthase, alpha
C2H98_03420	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2H98_03420	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2H98_03425	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C2H98_03440	COG4974	Belongs to the 'phage' integrase family
C2H98_03455	COG1725	Transcriptional regulator
C2H98_03465	COG0681	Belongs to the peptidase S26 family
C2H98_03480	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
C2H98_03485	COG0861	Integral membrane protein TerC family
C2H98_03490	COG1028	Short-chain dehydrogenase reductase Sdr
C2H98_03495	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2H98_03500	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2H98_03510	COG1418	mRNA catabolic process
C2H98_03515	COG0493	'glutamate synthase
C2H98_03520	COG0070	glutamate synthase
C2H98_03520	COG0069	glutamate synthase activity
C2H98_03520	COG0067	glutamate synthase
C2H98_03525	COG0583	DNA-binding transcription factor activity
C2H98_03530	COG1164	Oligoendopeptidase f
C2H98_03540	COG0561	phosphatase activity
C2H98_03550	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2H98_03575	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2H98_03580	COG2351	hydroxyisourate hydrolase activity
C2H98_03585	COG3195	allantoin biosynthetic process
C2H98_03585	COG3648	Uricase
C2H98_03590	COG2080	2 iron, 2 sulfur cluster binding
C2H98_03595	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2H98_03600	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C2H98_03610	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C2H98_03625	COG1388	LysM domain
C2H98_03625	COG3584	3D domain protein
C2H98_03630	COG5002	protein histidine kinase activity
C2H98_03640	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2H98_03645	COG0514	ATP-dependent DNA helicase (RecQ)
C2H98_03670	COG2116	formate transmembrane transporter activity
C2H98_03675	COG0488	(ABC) transporter
C2H98_03680	COG1686	Belongs to the peptidase S11 family
C2H98_03685	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C2H98_03685	COG0392	lysyltransferase activity
C2H98_03695	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C2H98_03705	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C2H98_03710	COG1335	isochorismatase
C2H98_03720	COG0706	membrane insertase activity
C2H98_03730	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C2H98_03745	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2H98_03750	COG0567	Dehydrogenase, E1 component
C2H98_03755	COG5002	protein histidine kinase activity
C2H98_03760	COG0745	RESPONSE REGULATOR receiver
C2H98_03770	COG0626	cystathionine gamma-synthase activity
C2H98_03775	COG0626	cystathionine gamma-synthase activity
C2H98_03780	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C2H98_03780	COG0646	methionine synthase
C2H98_03785	COG0646	methionine synthase
C2H98_03785	COG1410	methionine synthase
C2H98_03805	COG0477	Major facilitator Superfamily
C2H98_03810	COG1846	Transcriptional regulator
C2H98_03815	COG5504	Zn-dependent protease
C2H98_03820	COG0456	acetyltransferase
C2H98_03825	COG3153	acetyltransferase
C2H98_03825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2H98_03830	COG1960	acyl-CoA dehydrogenase activity
C2H98_03845	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C2H98_03850	COG3852	Histidine kinase
C2H98_03855	COG2843	Capsule synthesis protein
C2H98_03860	COG4841	protein insertion into membrane
C2H98_03880	COG0464	growth
C2H98_03895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H98_03900	COG1227	inorganic diphosphatase activity
C2H98_03910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H98_03930	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C2H98_03945	COG1486	melibiose metabolic process
C2H98_03950	COG5577	PFAM Coat F domain
C2H98_03960	COG1063	alcohol dehydrogenase
C2H98_03965	COG5577	PFAM Coat F domain
C2H98_03975	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2H98_03990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H98_03995	COG0456	acetyltransferase
C2H98_04010	COG3764	Sortase (surface protein transpeptidase)
C2H98_04020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2H98_04025	COG3973	AAA domain
C2H98_04030	COG1368	sulfuric ester hydrolase activity
C2H98_04035	COG1363	Peptidase, m42
C2H98_04040	COG1876	peptidase activity
C2H98_04045	COG0419	ATPase involved in DNA repair
C2H98_04050	COG0420	3'-5' exonuclease activity
C2H98_04055	COG1278	Cold shock
C2H98_04085	COG4846	Membrane protein involved in cytochrome C biogenesis
C2H98_04090	COG2201	protein-glutamate methylesterase activity
C2H98_04095	COG0785	Cytochrome C biogenesis protein
C2H98_04105	COG1132	(ABC) transporter
C2H98_04110	COG1132	(ABC) transporter
C2H98_04125	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2H98_04130	COG4224	UPF0291 protein
C2H98_04135	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2H98_04145	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2H98_04165	COG2080	2 iron, 2 sulfur cluster binding
C2H98_04175	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2H98_04250	COG0174	glutamine synthetase
C2H98_04255	COG0789	Transcriptional regulator
C2H98_04260	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
C2H98_04265	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2H98_04270	COG0464	growth
C2H98_04280	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C2H98_04290	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C2H98_04295	COG0157	Belongs to the NadC ModD family
C2H98_04300	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2H98_04305	COG1104	cysteine desulfurase activity
C2H98_04340	COG2244	polysaccharide biosynthetic process
C2H98_04405	COG3764	Sortase (surface protein transpeptidase)
C2H98_04425	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H98_04430	COG5002	protein histidine kinase activity
C2H98_04470	COG1028	Short-chain dehydrogenase reductase Sdr
C2H98_04475	COG0583	DNA-binding transcription factor activity
C2H98_04490	COG0412	Dienelactone hydrolase
C2H98_04510	COG1309	transcriptional regulator
C2H98_04515	COG2076	Multidrug Resistance protein
C2H98_04520	COG2076	Multidrug Resistance protein
C2H98_04570	COG5609	conserved protein (DUF2294)
C2H98_04575	COG0288	reversible hydration of carbon dioxide
C2H98_04580	COG3002	Belongs to the UPF0753 family
C2H98_04585	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2H98_04600	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C2H98_04605	COG3655	Transcriptional regulator
C2H98_04630	COG0316	Belongs to the HesB IscA family
C2H98_04635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2H98_04640	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2H98_04645	COG0022	dehydrogenase e1 component
C2H98_04650	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2H98_04670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H98_04685	COG4106	trans-aconitate 2-methyltransferase activity
C2H98_04730	COG2329	Antibiotic biosynthesis monooxygenase
C2H98_04735	COG0592	DNA-directed DNA polymerase activity
C2H98_04745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H98_04755	COG4549	nuclear export factor GLE1
C2H98_04760	COG0018	arginyl-trna synthetase
C2H98_04770	COG2207	Transcriptional regulator
C2H98_04770	COG3708	Transcriptional regulator
C2H98_04795	COG2267	carboxylic ester hydrolase activity
C2H98_04835	COG1011	Hydrolase
C2H98_04850	COG5002	protein histidine kinase activity
C2H98_04870	COG2814	Major facilitator Superfamily
C2H98_04875	COG1309	transcriptional regulator
C2H98_04880	COG1028	Short-chain dehydrogenase reductase Sdr
C2H98_04890	COG2814	Major facilitator Superfamily
C2H98_04895	COG0640	Transcriptional regulator
C2H98_04925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H98_04940	COG0596	Alpha beta hydrolase
C2H98_04945	COG2267	carboxylic ester hydrolase activity
C2H98_04965	COG0456	acetyltransferase
C2H98_04985	COG2318	DinB family
C2H98_05000	COG2814	Major facilitator Superfamily
C2H98_05005	COG0454	-acetyltransferase
C2H98_05015	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C2H98_05070	COG0789	Transcriptional regulator
C2H98_05085	COG0217	transcriptional regulatory protein
C2H98_05090	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2H98_05095	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2H98_05125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H98_05150	COG3546	catalase activity
C2H98_05175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H98_05180	COG3708	Transcriptional regulator
C2H98_05180	COG2207	Transcriptional regulator
C2H98_05190	COG1028	Short-chain dehydrogenase reductase Sdr
C2H98_05200	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C2H98_05230	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C2H98_05235	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H98_05235	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H98_05240	COG3716	PTS system mannose fructose sorbose family IID component
C2H98_05245	COG3715	PTS system
C2H98_05280	COG2169	Transcriptional regulator
C2H98_05285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2H98_05285	COG0723	plastoquinol--plastocyanin reductase activity
C2H98_05315	COG0768	penicillin binding
C2H98_05335	COG0076	glutamate decarboxylase activity
C2H98_05340	COG1794	racemase activity, acting on amino acids and derivatives
C2H98_05345	COG0574	Belongs to the PEP-utilizing enzyme family
C2H98_05345	COG3848	Pyruvate phosphate dikinase
C2H98_05365	COG0640	Transcriptional regulator
C2H98_05375	COG1028	Short-chain dehydrogenase reductase Sdr
C2H98_05380	COG4977	sequence-specific DNA binding
C2H98_05395	COG0531	amino acid
C2H98_05430	COG3773	Cell wall hydrolase
C2H98_05450	COG2207	Transcriptional regulator
C2H98_05455	COG2318	DinB family
C2H98_05465	COG2207	Transcriptional regulator
C2H98_05465	COG0662	Cupin 2, conserved barrel domain protein
C2H98_05470	COG0583	DNA-binding transcription factor activity
C2H98_05475	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2H98_05480	COG1846	Transcriptional regulator
C2H98_05480	COG0456	acetyltransferase
C2H98_05485	COG2271	Major facilitator Superfamily
C2H98_05490	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C2H98_05505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2H98_05520	COG0586	Pfam SNARE associated Golgi protein
C2H98_05525	COG2217	Heavy metal translocating P-type atpase
C2H98_05560	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2H98_05565	COG3711	transcriptional antiterminator
C2H98_05565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H98_05580	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C2H98_05585	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C2H98_05615	COG4550	Control of competence regulator ComK, YlbF/YmcA
C2H98_05620	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2H98_05630	COG2359	stage V sporulation protein S
C2H98_05635	COG1692	metallophosphoesterase
C2H98_05640	COG1418	mRNA catabolic process
C2H98_05645	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C2H98_05650	COG1058	Belongs to the CinA family
C2H98_05650	COG1546	Belongs to the CinA family
C2H98_05655	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2H98_05660	COG1426	Protein conserved in bacteria
C2H98_05675	COG0300	oxidoreductase activity
C2H98_05680	COG0612	Peptidase, M16
C2H98_05685	COG0612	Peptidase, M16
C2H98_05720	COG2188	Transcriptional regulator
C2H98_05725	COG4980	gas vesicle protein
C2H98_05725	COG1674	ftsk spoiiie
C2H98_05740	COG0740	serine-type endopeptidase activity
C2H98_05745	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C2H98_05750	COG1113	amino acid transport
C2H98_05755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2H98_05760	COG0527	aspartate kinase activity
C2H98_05765	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2H98_05770	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2H98_05775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2H98_05780	COG0612	Peptidase, M16
C2H98_05785	COG0726	polysaccharide deacetylase
C2H98_05790	COG1185	polyribonucleotide nucleotidyltransferase activity
C2H98_05795	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C2H98_05800	COG0196	riboflavin kinase activity
C2H98_05805	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C2H98_05815	COG1550	Protein conserved in bacteria
C2H98_05825	COG1358	cellular component organization or biogenesis
C2H98_05830	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C2H98_05835	COG0195	Participates in both transcription termination and antitermination
C2H98_05840	COG0779	Required for maturation of 30S ribosomal subunits
C2H98_05845	COG2176	DNA-directed DNA polymerase activity
C2H98_05850	COG0442	prolyl-tRNA aminoacylation
C2H98_05855	COG0750	zinc metalloprotease
C2H98_05865	COG4589	Belongs to the CDS family
C2H98_05870	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C2H98_05875	COG0233	cytoplasmic translational termination
C2H98_05880	COG0528	UMP kinase activity
C2H98_05905	COG1191	sigma factor activity
C2H98_05910	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C2H98_05915	COG1776	CheC inhibitor of MCP methylation
C2H98_05920	COG0835	chemotaxis
C2H98_05925	COG2198	Histidine kinase
C2H98_05925	COG0643	Histidine kinase
C2H98_05930	COG2201	protein-glutamate methylesterase activity
C2H98_05935	COG0455	bacterial-type flagellum organization
C2H98_05940	COG1419	protein localization to endoplasmic reticulum
C2H98_05945	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2H98_05950	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2H98_05955	COG1684	flagellar biosynthetic protein fliR
C2H98_05960	COG1987	bacterial-type flagellum assembly
C2H98_05965	COG1338	Plays a role in the flagellum-specific transport system
C2H98_05970	COG3190	flagellar
C2H98_05975	COG2201	protein-glutamate methylesterase activity
C2H98_05980	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2H98_05980	COG1776	CheC inhibitor of MCP methylation
C2H98_05985	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2H98_05990	COG1580	Controls the rotational direction of flagella during chemotaxis
C2H98_05995	COG1582	Flagellar protein (FlbD)
C2H98_06000	COG4786	Flagellar basal body rod
C2H98_06010	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C2H98_06025	COG2882	bacterial-type flagellum organization
C2H98_06030	COG1157	protein secretion by the type III secretion system
C2H98_06035	COG1317	bacterial-type flagellum organization
C2H98_06040	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2H98_06045	COG1766	The M ring may be actively involved in energy transduction
C2H98_06050	COG1677	Flagellar hook-basal body complex protein FliE
C2H98_06055	COG1558	bacterial-type flagellum-dependent cell motility
C2H98_06060	COG1815	bacterial-type flagellum-dependent cell motility
C2H98_06065	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C2H98_06070	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C2H98_06080	COG4974	Belongs to the 'phage' integrase family
C2H98_06085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2H98_06090	COG0758	DNA mediated transformation
C2H98_06095	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2H98_06100	COG0045	succinate-CoA ligase (ADP-forming) activity
C2H98_06105	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2H98_06120	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C2H98_06125	COG0681	Belongs to the peptidase S26 family
C2H98_06140	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C2H98_06150	COG1837	Belongs to the UPF0109 family
C2H98_06160	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2H98_06185	COG0714	Associated with various cellular activities
C2H98_06200	COG1131	(ABC) transporter
C2H98_06215	COG0552	protein localization to endoplasmic reticulum
C2H98_06220	COG1196	nuclear chromosome segregation
C2H98_06225	COG0571	ribonuclease III activity
C2H98_06230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2H98_06235	COG1028	Short-chain dehydrogenase reductase Sdr
C2H98_06240	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2H98_06245	COG0416	fatty acid biosynthetic process
C2H98_06250	COG1349	DNA-binding transcription factor activity
C2H98_06255	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2H98_06260	COG1760	l-serine dehydratase
C2H98_06265	COG1760	l-serine dehydratase
C2H98_06270	COG1461	Dihydroxyacetone kinase
C2H98_06275	COG1302	Protein conserved in bacteria
C2H98_06280	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C2H98_06290	COG1564	THIamine pyrophosphokinase
C2H98_06295	COG1162	GTPase activity
C2H98_06300	COG2815	serine threonine protein kinase
C2H98_06300	COG0515	serine threonine protein kinase
C2H98_06305	COG0631	protein serine/threonine phosphatase activity
C2H98_06315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2H98_06315	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2H98_06320	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C2H98_06330	COG3250	beta-galactosidase activity
C2H98_06345	COG3833	ABC-type maltose transport systems, permease component
C2H98_06365	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2H98_06370	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2H98_06380	COG0194	GDP metabolic process
C2H98_06385	COG2052	Domain of unknown function (DUF370)
C2H98_06390	COG1561	YicC-like family, N-terminal region
C2H98_06395	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C2H98_06415	COG0167	dihydroorotate dehydrogenase activity
C2H98_06425	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C2H98_06435	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2H98_06440	COG0540	Belongs to the ATCase OTCase family
C2H98_06450	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C2H98_06455	COG0564	pseudouridine synthase activity
C2H98_06460	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C2H98_06465	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2H98_06470	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C2H98_06475	COG3599	regulation of cell shape
C2H98_06480	COG2302	S4 RNA-binding domain
C2H98_06485	COG0762	integral membrane protein
C2H98_06490	COG1799	cell septum assembly
C2H98_06495	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2H98_06505	COG1191	sigma factor activity
C2H98_06510	COG1191	sigma factor activity
C2H98_06520	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C2H98_06525	COG0849	cell division
C2H98_06530	COG3856	small basic protein
C2H98_06535	COG3879	Bacterial protein of unknown function (DUF881)
C2H98_06540	COG3879	Bacterial protein of unknown function (DUF881)
C2H98_06545	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C2H98_06550	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2H98_06555	COG0772	Belongs to the SEDS family
C2H98_06560	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C2H98_06565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2H98_06575	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2H98_06580	COG0768	penicillin binding
C2H98_06605	COG2001	Belongs to the MraZ family
C2H98_06610	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
C2H98_06630	COG1683	Conserved Protein
C2H98_06640	COG1399	metal-binding, possibly nucleic acid-binding protein
C2H98_06645	COG1323	Belongs to the UPF0348 family
C2H98_06650	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2H98_06655	COG3314	Sporulation integral membrane protein YlbJ
C2H98_06660	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C2H98_06665	COG0742	ribosomal rna small subunit methyltransferase
C2H98_06670	COG4471	UPF0298 protein
C2H98_06675	COG3679	Belongs to the UPF0342 family
C2H98_06695	COG2340	Cysteine-rich secretory protein family
C2H98_06710	COG0772	Belongs to the SEDS family
C2H98_06720	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2H98_06725	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C2H98_06735	COG4896	Protein conserved in bacteria
C2H98_06760	COG0483	inositol monophosphate 1-phosphatase activity
C2H98_06770	COG4493	Belongs to the UPF0637 family
C2H98_06780	COG1982	Orn Lys Arg decarboxylase major
C2H98_06800	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2H98_06805	COG0022	dehydrogenase e1 component
C2H98_06830	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C2H98_06835	COG0569	domain protein
C2H98_06840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H98_06845	COG0668	transmembrane transport
C2H98_06850	COG1473	amidohydrolase
C2H98_06855	COG2171	N-acyltransferase activity
C2H98_06860	COG0583	DNA-binding transcription factor activity
C2H98_06865	COG0517	IMP dehydrogenase activity
C2H98_06870	COG4703	Protein of unknown function (DUF1797)
C2H98_06885	COG2200	EAL domain
C2H98_06890	COG4990	cell redox homeostasis
C2H98_06895	COG3300	MHYT domain
C2H98_06895	COG5001	Diguanylate cyclase
C2H98_06910	COG0835	chemotaxis
C2H98_06910	COG0784	Response regulator, receiver
C2H98_06930	COG0436	Aminotransferase
C2H98_06935	COG2084	Dehydrogenase
C2H98_06940	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C2H98_06945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2H98_06965	COG4873	Protein conserved in bacteria
C2H98_06980	COG3949	Membrane
C2H98_06985	COG0542	response to heat
C2H98_06995	COG1846	Transcriptional regulator
C2H98_07000	COG3852	Histidine kinase
C2H98_07010	COG0436	Aminotransferase
C2H98_07015	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2H98_07025	COG5002	protein histidine kinase activity
C2H98_07030	COG3594	Acyltransferase
C2H98_07035	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2H98_07045	COG0861	Integral membrane protein TerC family
C2H98_07055	COG1126	abc transporter atp-binding protein
C2H98_07060	COG0765	amino acid transport
C2H98_07065	COG4597	amino acid ABC transporter
C2H98_07070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H98_07075	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C2H98_07080	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2H98_07095	COG1510	regulation of RNA biosynthetic process
C2H98_07100	COG0517	IMP dehydrogenase activity
C2H98_07100	COG4175	Glycine betaine
C2H98_07105	COG4176	ABC-type proline glycine betaine transport system permease component
C2H98_07110	COG2113	Glycine betaine
C2H98_07115	COG2268	Band 7 protein
C2H98_07120	COG1585	Membrane protein implicated in regulation of membrane protease activity
C2H98_07130	COG0561	phosphatase activity
C2H98_07135	COG1119	ATPase activity
C2H98_07140	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H98_07145	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C2H98_07160	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C2H98_07180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2H98_07185	COG1121	(ABC) transporter
C2H98_07190	COG3883	PFAM NLP P60 protein
C2H98_07190	COG0791	NLP P60 protein
C2H98_07195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2H98_07200	COG4193	domain, Protein
C2H98_07205	COG0252	asparaginase activity
C2H98_07215	COG0778	Nitroreductase
C2H98_07225	COG1252	NADH dehydrogenase
C2H98_07235	COG2205	protein histidine kinase activity
C2H98_07240	COG1113	amino acid transport
C2H98_07250	COG2814	Major facilitator Superfamily
C2H98_07255	COG1063	alcohol dehydrogenase
C2H98_07260	COG0583	DNA-binding transcription factor activity
C2H98_07275	COG0772	Belongs to the SEDS family
C2H98_07285	COG1595	DNA-templated transcription, initiation
C2H98_07300	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2H98_07305	COG0673	inositol 2-dehydrogenase activity
C2H98_07310	COG1082	Xylose isomerase domain protein TIM barrel
C2H98_07315	COG0673	inositol 2-dehydrogenase activity
C2H98_07325	COG2169	Transcriptional regulator
C2H98_07330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2H98_07345	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2H98_07350	COG1404	Belongs to the peptidase S8 family
C2H98_07355	COG1266	CAAX protease self-immunity
C2H98_07385	COG2207	Transcriptional regulator
C2H98_07385	COG4753	response regulator
C2H98_07390	COG2972	Histidine kinase
C2H98_07400	COG5578	integral membrane protein
C2H98_07405	COG3254	rhamnose metabolic process
C2H98_07415	COG0395	ABC-type sugar transport system, permease component
C2H98_07420	COG1175	transmembrane transport
C2H98_07425	COG2017	converts alpha-aldose to the beta-anomer
C2H98_07430	COG0366	Alpha amylase catalytic
C2H98_07450	COG1595	DNA-templated transcription, initiation
C2H98_07455	COG1012	belongs to the aldehyde dehydrogenase family
C2H98_07470	COG1136	(ABC) transporter
C2H98_07480	COG5002	protein histidine kinase activity
C2H98_07480	COG3850	Histidine kinase
C2H98_07515	COG4555	ABC transporter
C2H98_07520	COG1113	amino acid transport
C2H98_07525	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2H98_07535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2H98_07540	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C2H98_07545	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C2H98_07560	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2H98_07570	COG2207	Transcriptional regulator
C2H98_07575	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C2H98_07595	COG3940	Belongs to the glycosyl hydrolase 43 family
C2H98_07600	COG5578	integral membrane protein
C2H98_07605	COG3507	Belongs to the glycosyl hydrolase 43 family
C2H98_07610	COG0395	ABC-type sugar transport system, permease component
C2H98_07625	COG0431	NADPH-dependent FMN reductase
C2H98_07650	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2H98_07660	COG0302	gtp cyclohydrolase
C2H98_07670	COG0720	synthase
C2H98_07680	COG1266	CAAX protease self-immunity
C2H98_07700	COG1953	Uracil, thiamine, allantoin
C2H98_07705	COG2508	Transcriptional regulator
C2H98_07735	COG1234	tRNA 3'-trailer cleavage
C2H98_07740	COG0142	geranyltranstransferase activity
C2H98_07755	COG0584	glycerophosphoryl diester phosphodiesterase
C2H98_07760	COG0584	glycerophosphoryl diester phosphodiesterase
C2H98_07780	COG3842	ATPase activity
C2H98_07790	COG1811	Na channel or pump
C2H98_07800	COG0583	DNA-binding transcription factor activity
C2H98_07810	COG3507	Belongs to the glycosyl hydrolase 43 family
C2H98_07820	COG0129	dihydroxy-acid dehydratase activity
C2H98_07825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2H98_07830	COG1414	Transcriptional regulator
C2H98_07840	COG3773	Cell wall hydrolase
C2H98_07845	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2H98_07850	COG1874	Beta-galactosidase
C2H98_07855	COG0395	ABC-type sugar transport system, permease component
C2H98_07870	COG2207	Transcriptional regulator
C2H98_07870	COG0662	Cupin 2, conserved barrel domain protein
C2H98_07880	COG1732	Glycine betaine
C2H98_07890	COG0515	serine threonine protein kinase
C2H98_07895	COG3773	Cell wall hydrolase
C2H98_07900	COG1082	Xylose isomerase domain protein TIM barrel
C2H98_07920	COG0673	inositol 2-dehydrogenase activity
C2H98_07930	COG0395	ABC-type sugar transport system, permease component
C2H98_07935	COG1175	transmembrane transport
C2H98_07945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H98_07955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2H98_07990	COG3588	fructose-bisphosphate aldolase
C2H98_08000	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C2H98_08005	COG0523	cobalamin synthesis protein
C2H98_08035	COG2271	Major facilitator Superfamily
C2H98_08045	COG3604	Transcriptional regulator
C2H98_08050	COG2116	formate transmembrane transporter activity
C2H98_08060	COG1587	Uroporphyrinogen-III synthase
C2H98_08060	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2H98_08065	COG2146	nitrite reductase [NAD(P)H] activity
C2H98_08070	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2H98_08080	COG2723	6-phospho-beta-galactosidase activity
C2H98_08095	COG0405	Gamma-glutamyltransferase
C2H98_08100	COG2271	Major facilitator Superfamily
C2H98_08105	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2H98_08110	COG0583	DNA-binding transcription factor activity
C2H98_08115	COG2972	Histidine kinase
C2H98_08120	COG4753	response regulator
C2H98_08120	COG2207	Transcriptional regulator
C2H98_08125	COG1653	transport
C2H98_08130	COG1621	beta-fructofuranosidase activity
C2H98_08135	COG1621	beta-fructofuranosidase activity
C2H98_08140	COG1621	beta-fructofuranosidase activity
C2H98_08145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H98_08150	COG1621	beta-fructofuranosidase activity
C2H98_08160	COG0395	ABC-type sugar transport system, permease component
C2H98_08165	COG4209	transmembrane transport
C2H98_08170	COG1609	Transcriptional regulator
C2H98_08175	COG0697	spore germination
C2H98_08180	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2H98_08185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2H98_08190	COG1116	anion transmembrane transporter activity
C2H98_08195	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H98_08200	COG2814	Major facilitator Superfamily
C2H98_08230	COG1175	transmembrane transport
C2H98_08240	COG2972	Histidine kinase
C2H98_08245	COG3279	Response regulator of the LytR AlgR family
C2H98_08250	COG0655	NAD(P)H dehydrogenase (quinone) activity
C2H98_08255	COG0840	transmembrane signaling receptor activity
C2H98_08260	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2H98_08290	COG0745	RESPONSE REGULATOR receiver
C2H98_08295	COG2205	protein histidine kinase activity
C2H98_08330	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2H98_08335	COG3546	catalase activity
C2H98_08340	COG3162	membrane
C2H98_08345	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2H98_08355	COG5577	PFAM Coat F domain
C2H98_08370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2H98_08375	COG2210	Belongs to the sulfur carrier protein TusA family
C2H98_08380	COG1937	Protein conserved in bacteria
C2H98_08385	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2H98_08400	COG1523	belongs to the glycosyl hydrolase 13 family
C2H98_08405	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2H98_08410	COG1309	transcriptional regulator
C2H98_08415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2H98_08420	COG1834	amidinotransferase
C2H98_08430	COG3541	Predicted nucleotidyltransferase
C2H98_08435	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C2H98_08440	COG1216	Glycosyl transferase, family 2
C2H98_08465	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2H98_08475	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C2H98_08480	COG1263	PTS System
C2H98_08480	COG2190	(PTS) system
C2H98_08480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H98_08485	COG0366	Alpha amylase catalytic
C2H98_08490	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H98_08500	COG1349	DNA-binding transcription factor activity
C2H98_08505	COG4214	carbohydrate transport
C2H98_08525	COG2972	Histidine kinase
C2H98_08535	COG4806	L-rhamnose isomerase
C2H98_08540	COG1070	Carbohydrate kinase
C2H98_08555	COG3347	Dehydrogenase
C2H98_08555	COG1028	Short-chain dehydrogenase reductase Sdr
C2H98_08570	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2H98_08580	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2H98_08595	COG3104	oligopeptide transport
C2H98_08600	COG1595	DNA-templated transcription, initiation
C2H98_08605	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C2H98_08615	COG0363	glucosamine-6-phosphate deaminase activity
C2H98_08620	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2H98_08625	COG1609	Transcriptional regulator
C2H98_08630	COG1215	transferase activity, transferring glycosyl groups
C2H98_08635	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
C2H98_08640	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2H98_08645	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C2H98_08650	COG2169	Transcriptional regulator
C2H98_08660	COG1070	Carbohydrate kinase
C2H98_08670	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C2H98_08675	COG1737	Transcriptional regulator
C2H98_08690	COG1136	(ABC) transporter
C2H98_08690	COG0577	efflux transmembrane transporter activity
C2H98_08700	COG0726	polysaccharide deacetylase
C2H98_08715	COG0431	NADPH-dependent FMN reductase
C2H98_08725	COG0602	queuosine metabolic process
C2H98_08730	COG1328	CTP reductase activity
C2H98_08735	COG2382	esterase
C2H98_08740	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C2H98_08745	COG2153	protein acetylation
C2H98_08750	COG2323	membrane
C2H98_08760	COG0210	DNA helicase
C2H98_08780	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2H98_08810	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2H98_08815	COG0475	glutathione-regulated potassium exporter activity
C2H98_08815	COG0569	domain protein
C2H98_08820	COG2239	Acts as a magnesium transporter
C2H98_08825	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2H98_08830	COG0564	pseudouridine synthase activity
C2H98_08835	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C2H98_08840	COG2357	RelA SpoT domain protein
C2H98_08850	COG4116	CYTH
C2H98_08855	COG0741	lytic transglycosylase activity
C2H98_08860	COG2346	COG2346, Truncated hemoglobins
C2H98_08870	COG1164	Oligoendopeptidase f
C2H98_08880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2H98_08885	COG4862	establishment of competence for transformation
C2H98_08890	COG1393	Belongs to the ArsC family
C2H98_08895	COG0456	acetyltransferase
C2H98_08905	COG4608	Belongs to the ABC transporter superfamily
C2H98_08910	COG0444	Belongs to the ABC transporter superfamily
C2H98_08915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2H98_08920	COG0601	transmembrane transport
C2H98_08925	COG4166	transmembrane transport
C2H98_08930	COG0180	Tryptophanyl-tRNA synthetase
C2H98_08940	COG5504	Zn-dependent protease
C2H98_08945	COG0735	belongs to the Fur family
C2H98_08950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2H98_08955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2H98_08965	COG1744	ABC transporter substrate-binding protein PnrA-like
C2H98_08975	COG2267	carboxylic ester hydrolase activity
C2H98_08995	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C2H98_09015	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C2H98_09020	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C2H98_09025	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C2H98_09030	COG1556	Lactate utilization protein
C2H98_09035	COG1139	Iron-sulfur cluster binding protein
C2H98_09040	COG0247	lactate metabolic process
C2H98_09045	COG2186	Transcriptional regulator
C2H98_09050	COG1620	l-lactate permease
C2H98_09055	COG0303	'Molybdopterin
C2H98_09060	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2H98_09065	COG2151	metal-sulfur cluster biosynthetic enzyme
C2H98_09070	COG1073	alpha beta
C2H98_09075	COG0561	phosphatase activity
C2H98_09090	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H98_09095	COG1307	EDD domain protein, DegV family
C2H98_09105	COG2996	Protein conserved in bacteria
C2H98_09110	COG1666	GTP binding
C2H98_09115	COG1028	Short-chain dehydrogenase reductase Sdr
C2H98_09125	COG0697	spore germination
C2H98_09130	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2H98_09135	COG0367	asparagine synthase
C2H98_09145	COG1247	-acetyltransferase
C2H98_09160	COG0662	Cupin 2, conserved barrel domain protein
C2H98_09160	COG2207	Transcriptional regulator
C2H98_09170	COG0673	inositol 2-dehydrogenase activity
C2H98_09175	COG0673	inositol 2-dehydrogenase activity
C2H98_09180	COG1737	Transcriptional regulator
C2H98_09190	COG1131	(ABC) transporter
C2H98_09195	COG2226	methyltransferase
C2H98_09210	COG1131	(ABC) transporter
C2H98_09215	COG1253	flavin adenine dinucleotide binding
C2H98_09220	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H98_09225	COG2197	response regulator
C2H98_09230	COG4585	Histidine kinase
C2H98_09240	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2H98_09285	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C2H98_09295	COG0398	Pfam SNARE associated Golgi protein
C2H98_09300	COG1316	TRANSCRIPTIONal
C2H98_09305	COG0823	Involved in the tonB-independent uptake of proteins
C2H98_09305	COG1506	peptidase
C2H98_09305	COG4946	Tricorn protease homolog
C2H98_09325	COG0501	Belongs to the peptidase M48B family
C2H98_09330	COG0095	Lipoate-protein ligase
C2H98_09335	COG1511	domain protein
C2H98_09340	COG1309	transcriptional regulator
C2H98_09350	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C2H98_09360	COG2197	response regulator
C2H98_09365	COG4585	Histidine kinase
C2H98_09375	COG3069	C4-dicarboxylate transmembrane transporter activity
C2H98_09385	COG1473	amidohydrolase
C2H98_09395	COG4473	ABC transporter
C2H98_09400	COG1131	(ABC) transporter
C2H98_09405	COG0537	adenosine 5'-monophosphoramidase activity
C2H98_09410	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C2H98_09420	COG1846	Transcriptional regulator
C2H98_09455	COG4717	serine-type aminopeptidase activity
C2H98_09460	COG0420	3'-5' exonuclease activity
C2H98_09465	COG1668	transmembrane transport
C2H98_09470	COG4152	abc transporter atp-binding protein
C2H98_09475	COG2252	PERMEase
C2H98_09480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2H98_09485	COG0561	phosphatase activity
C2H98_09505	COG0189	ligase activity
C2H98_09510	COG0189	ligase activity
C2H98_09515	COG0189	ligase activity
C2H98_09520	COG2508	Transcriptional regulator
C2H98_09525	COG3842	ATPase activity
C2H98_09545	COG2819	hydrolase of the alpha beta superfamily
C2H98_09550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H98_09555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H98_09560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H98_09565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H98_09565	COG2207	Transcriptional regulator
C2H98_09570	COG2819	hydrolase of the alpha beta superfamily
C2H98_09575	COG1132	(ABC) transporter
C2H98_09580	COG1132	(ABC) transporter
C2H98_09585	COG2814	Major facilitator Superfamily
C2H98_09600	COG5278	phosphoserine phosphatase activity
C2H98_09600	COG0840	transmembrane signaling receptor activity
C2H98_09605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H98_09610	COG1253	flavin adenine dinucleotide binding
C2H98_09615	COG1253	flavin adenine dinucleotide binding
C2H98_09620	COG0745	RESPONSE REGULATOR receiver
C2H98_09625	COG0598	Magnesium transport protein CorA
C2H98_09630	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H98_09640	COG1131	(ABC) transporter
C2H98_09645	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C2H98_09665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H98_09680	COG1902	pentaerythritol trinitrate reductase activity
C2H98_09690	COG1309	transcriptional regulator
C2H98_09705	COG2910	NAD(P)H-binding
C2H98_09710	COG1959	2 iron, 2 sulfur cluster binding
C2H98_09715	COG0346	lactoylglutathione lyase activity
C2H98_09725	COG0528	UMP kinase activity
C2H98_09750	COG0346	lactoylglutathione lyase activity
C2H98_09765	COG2378	regulation of single-species biofilm formation
C2H98_09795	COG2076	Multidrug Resistance protein
C2H98_09800	COG1309	transcriptional regulator
C2H98_09805	COG0583	DNA-binding transcription factor activity
C2H98_09820	COG2252	PERMEase
C2H98_09845	COG3153	acetyltransferase
C2H98_09845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2H98_09850	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C2H98_09855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H98_09865	COG0564	pseudouridine synthase activity
C2H98_09870	COG2261	transglycosylase associated protein
C2H98_09875	COG0656	L-ascorbic acid biosynthetic process
C2H98_09880	COG1028	Short-chain dehydrogenase reductase Sdr
C2H98_09885	COG1392	Phosphate transport regulator
C2H98_09890	COG0306	phosphate transporter
C2H98_09900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H98_09905	COG5002	protein histidine kinase activity
C2H98_09910	COG0745	RESPONSE REGULATOR receiver
C2H98_09930	COG0745	RESPONSE REGULATOR receiver
C2H98_09930	COG3706	GGDEF domain
C2H98_09935	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2H98_09950	COG1396	sequence-specific DNA binding
C2H98_09960	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2H98_09965	COG3239	Fatty acid desaturase
C2H98_09970	COG4585	Histidine kinase
C2H98_09975	COG2197	response regulator
C2H98_09985	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C2H98_09990	COG1028	Short-chain dehydrogenase reductase Sdr
C2H98_09995	COG1312	Catalyzes the dehydration of D-mannonate
C2H98_10005	COG3250	beta-galactosidase activity
C2H98_10010	COG2211	Major facilitator Superfamily
C2H98_10015	COG2207	Transcriptional regulator
C2H98_10020	COG2315	Protein conserved in bacteria
C2H98_10025	COG0697	spore germination
C2H98_10030	COG1917	Cupin 2, conserved barrel domain protein
C2H98_10030	COG2207	Transcriptional regulator
C2H98_10035	COG2329	Antibiotic biosynthesis monooxygenase
C2H98_10060	COG1335	isochorismatase
C2H98_10065	COG1694	Mazg nucleotide pyrophosphohydrolase
C2H98_10105	COG1028	Short-chain dehydrogenase reductase Sdr
C2H98_10110	COG1733	regulation of RNA biosynthetic process
C2H98_10115	COG0346	lactoylglutathione lyase activity
C2H98_10170	COG0662	Cupin 2, conserved barrel domain protein
C2H98_10180	COG0583	DNA-binding transcription factor activity
C2H98_10215	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
C2H98_10220	COG1733	regulation of RNA biosynthetic process
C2H98_10225	COG0500	methyltransferase
C2H98_10235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H98_10235	COG1263	PTS System
C2H98_10240	COG4977	sequence-specific DNA binding
C2H98_10240	COG1917	Cupin 2, conserved barrel domain protein
C2H98_10245	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C2H98_10265	COG0641	radical SAM
C2H98_10270	COG2190	(PTS) system
C2H98_10270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H98_10270	COG1263	PTS System
C2H98_10275	COG2723	6-phospho-beta-galactosidase activity
C2H98_10280	COG1737	Transcriptional regulator
C2H98_10290	COG0667	Aldo Keto reductase
C2H98_10305	COG2832	Protein of unknown function (DUF454)
C2H98_10335	COG2766	serine protein kinase
C2H98_10340	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2H98_10345	COG0778	Nitroreductase
C2H98_10360	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C2H98_10365	COG3382	B3 4 domain protein
C2H98_10380	COG2116	formate transmembrane transporter activity
C2H98_10395	COG1063	alcohol dehydrogenase
C2H98_10410	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C2H98_10425	COG0586	Pfam SNARE associated Golgi protein
C2H98_10430	COG1733	regulation of RNA biosynthetic process
C2H98_10440	COG0789	Transcriptional regulator
C2H98_10445	COG4221	oxidoreductase activity
C2H98_10460	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2H98_10465	COG0741	lytic transglycosylase activity
C2H98_10475	COG2814	Major facilitator Superfamily
C2H98_10475	COG0477	Major facilitator Superfamily
C2H98_10480	COG2207	Transcriptional regulator
C2H98_10480	COG4753	response regulator
C2H98_10485	COG2972	Histidine kinase
C2H98_10500	COG0431	NADPH-dependent FMN reductase
C2H98_10505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H98_10520	COG2391	methyltransferase activity
C2H98_10525	COG1378	Sugar-specific transcriptional regulator TrmB
C2H98_10535	COG0655	NAD(P)H dehydrogenase (quinone) activity
C2H98_10540	COG0400	carboxylic ester hydrolase activity
C2H98_10545	COG0346	lactoylglutathione lyase activity
C2H98_10550	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2H98_10555	COG0346	lactoylglutathione lyase activity
C2H98_10560	COG1846	Transcriptional regulator
C2H98_10580	COG2205	protein histidine kinase activity
C2H98_10585	COG0745	RESPONSE REGULATOR receiver
C2H98_10630	COG2723	6-phospho-beta-galactosidase activity
C2H98_10640	COG0789	Transcriptional regulator
C2H98_10645	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
C2H98_10665	COG2814	Major facilitator Superfamily
C2H98_10670	COG1984	allophanate hydrolase subunit 2
C2H98_10675	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C2H98_10680	COG2723	6-phospho-beta-galactosidase activity
C2H98_10685	COG1263	PTS System
C2H98_10685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H98_10685	COG2190	(PTS) system
C2H98_10690	COG3711	transcriptional antiterminator
C2H98_10695	COG1902	pentaerythritol trinitrate reductase activity
C2H98_10700	COG0577	efflux transmembrane transporter activity
C2H98_10705	COG1136	(ABC) transporter
C2H98_10710	COG2205	protein histidine kinase activity
C2H98_10715	COG0745	RESPONSE REGULATOR receiver
C2H98_10720	COG5578	integral membrane protein
C2H98_10725	COG3401	FG-GAP repeat protein
C2H98_10735	COG0395	ABC-type sugar transport system, permease component
C2H98_10740	COG4209	transmembrane transport
C2H98_10745	COG1653	transport
C2H98_10750	COG2207	Transcriptional regulator
C2H98_10755	COG2755	lipolytic protein G-D-S-L family
C2H98_10760	COG4977	sequence-specific DNA binding
C2H98_10765	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C2H98_10775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H98_10780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H98_10785	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H98_10795	COG0697	spore germination
C2H98_10800	COG0789	Transcriptional regulator
C2H98_10805	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C2H98_10805	COG0456	acetyltransferase
C2H98_10830	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2H98_10830	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2H98_10835	COG3443	Belongs to the bacterial solute-binding protein 9 family
C2H98_10840	COG0477	Major facilitator Superfamily
C2H98_10855	COG1846	Transcriptional regulator
C2H98_10865	COG1304	FMN binding
C2H98_10915	COG0604	alcohol dehydrogenase
C2H98_10915	COG1028	Short-chain dehydrogenase reductase Sdr
C2H98_10915	COG3321	synthase
C2H98_10935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2H98_10940	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C2H98_10945	COG4221	oxidoreductase activity
C2H98_10975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H98_10975	COG3711	transcriptional antiterminator
C2H98_10980	COG2723	6-phospho-beta-galactosidase activity
C2H98_10985	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H98_11000	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2H98_11010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H98_11020	COG1132	(ABC) transporter
C2H98_11035	COG5002	protein histidine kinase activity
C2H98_11035	COG0642	Histidine kinase
C2H98_11040	COG0745	RESPONSE REGULATOR receiver
C2H98_11045	COG0398	Pfam SNARE associated Golgi protein
C2H98_11065	COG1401	restriction endodeoxyribonuclease activity
C2H98_11230	COG0735	belongs to the Fur family
C2H98_11235	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2H98_11245	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2H98_11250	COG4129	membrane
C2H98_11255	COG1132	(ABC) transporter
C2H98_11275	COG1028	Short-chain dehydrogenase reductase Sdr
C2H98_11285	COG1194	a g-specific adenine glycosylase
C2H98_11290	COG1988	membrane-bound metal-dependent
C2H98_11310	COG2137	regulation of response to DNA damage stimulus
C2H98_11320	COG3507	Belongs to the glycosyl hydrolase 43 family
C2H98_11325	COG2706	6-phosphogluconolactonase activity
C2H98_11330	COG1607	acyl-coa hydrolase
C2H98_11345	COG4708	membrane
C2H98_11350	COG0384	phenazine biosynthesis protein PhzF
C2H98_11355	COG3853	Toxic anion resistance protein (TelA)
C2H98_11360	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
C2H98_11365	COG2223	nitrite transmembrane transporter activity
C2H98_11370	COG3279	Response regulator of the LytR AlgR family
C2H98_11375	COG3275	phosphorelay sensor kinase activity
C2H98_11395	COG0840	transmembrane signaling receptor activity
C2H98_11420	COG1132	(ABC) transporter
C2H98_11425	COG1132	(ABC) transporter
C2H98_11440	COG1595	DNA-templated transcription, initiation
C2H98_11445	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2H98_11450	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2H98_11455	COG1780	Probably involved in ribonucleotide reductase function
C2H98_11465	COG3534	alpha-L-arabinofuranosidase
C2H98_11490	COG0534	Mate efflux family protein
C2H98_11500	COG4260	virion core protein, lumpy skin disease virus
C2H98_11505	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C2H98_11510	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2H98_11515	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C2H98_11535	COG0322	excinuclease ABC activity
C2H98_11540	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2H98_11555	COG0765	amino acid transport
C2H98_11565	COG1733	regulation of RNA biosynthetic process
C2H98_11570	COG0702	epimerase
C2H98_11580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2H98_11600	COG2211	Major facilitator Superfamily
C2H98_11605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2H98_11610	COG4214	carbohydrate transport
C2H98_11615	COG1129	ABC transporter
C2H98_11620	COG4213	ABC transporter substrate-binding protein
C2H98_11625	COG4753	response regulator
C2H98_11625	COG2207	Transcriptional regulator
C2H98_11640	COG0704	Plays a role in the regulation of phosphate uptake
C2H98_11650	COG0581	inorganic phosphate transmembrane transporter activity
C2H98_11655	COG0573	inorganic phosphate transmembrane transporter activity
C2H98_11660	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2H98_11675	COG1174	glycine betaine transport
C2H98_11680	COG1125	glycine betaine transport
C2H98_11680	COG0517	IMP dehydrogenase activity
C2H98_11710	COG0583	DNA-binding transcription factor activity
C2H98_11725	COG4807	Protein conserved in bacteria
C2H98_11735	COG4191	Histidine kinase
C2H98_11745	COG0737	Belongs to the 5'-nucleotidase family
C2H98_11755	COG3940	Belongs to the glycosyl hydrolase 43 family
C2H98_11760	COG0488	(ABC) transporter
C2H98_11770	COG1511	domain protein
C2H98_11775	COG1674	ftsk spoiiie
C2H98_11775	COG0433	COG0433 Predicted ATPase
C2H98_11780	COG4499	WXG100 protein secretion system (Wss), protein YukC
C2H98_11785	COG5417	Belongs to the EsaB family
C2H98_11790	COG4842	Belongs to the WXG100 family
C2H98_11825	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2H98_11830	COG0562	UDP-galactopyranose mutase
C2H98_11835	COG0463	Glycosyl transferase, family 2
C2H98_11860	COG2204	response regulator
C2H98_11875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2H98_11890	COG1959	2 iron, 2 sulfur cluster binding
C2H98_11900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H98_11905	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C2H98_11925	COG1309	transcriptional regulator
C2H98_11940	COG0535	radical SAM domain protein
C2H98_11950	COG2364	Membrane
C2H98_11955	COG0387	Pfam Sodium calcium exchanger
C2H98_11960	COG0477	Major facilitator Superfamily
C2H98_11965	COG2217	Heavy metal translocating P-type atpase
C2H98_11970	COG1295	ribonuclease BN
C2H98_11980	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2H98_11985	COG4840	Belongs to the UPF0435 family
C2H98_11990	COG0024	Methionine aminopeptidase
C2H98_11995	COG0693	protein deglycase activity
C2H98_12000	COG2188	Transcriptional regulator
C2H98_12005	COG1396	sequence-specific DNA binding
C2H98_12015	COG1396	sequence-specific DNA binding
C2H98_12020	COG2313	pseudouridylate synthase activity
C2H98_12025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H98_12025	COG1522	sequence-specific DNA binding
C2H98_12030	COG1360	Flagellar Motor Protein
C2H98_12035	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2H98_12045	COG0551	DNA topoisomerase type I activity
C2H98_12045	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2H98_12050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2H98_12055	COG2309	aminopeptidase activity
C2H98_12065	COG1254	Belongs to the acylphosphatase family
C2H98_12070	COG1970	mechanosensitive ion channel activity
C2H98_12075	COG0670	Belongs to the BI1 family
C2H98_12085	COG1607	acyl-coa hydrolase
C2H98_12090	COG0598	Magnesium transport protein CorA
C2H98_12105	COG2244	polysaccharide biosynthetic process
C2H98_12110	COG2197	response regulator
C2H98_12140	COG0697	spore germination
C2H98_12145	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2H98_12160	COG0513	Belongs to the DEAD box helicase family
C2H98_12165	COG2357	RelA SpoT domain protein
C2H98_12170	COG1132	(ABC) transporter
C2H98_12175	COG1132	(ABC) transporter
C2H98_12185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2H98_12190	COG0601	transmembrane transport
C2H98_12195	COG4608	Belongs to the ABC transporter superfamily
C2H98_12200	COG0444	Belongs to the ABC transporter superfamily
C2H98_12205	COG1473	amidohydrolase
C2H98_12210	COG1473	amidohydrolase
C2H98_12215	COG2205	protein histidine kinase activity
C2H98_12220	COG0745	RESPONSE REGULATOR receiver
C2H98_12240	COG0527	aspartate kinase activity
C2H98_12245	COG2814	Major facilitator Superfamily
C2H98_12255	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C2H98_12265	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2H98_12280	COG1132	(ABC) transporter
C2H98_12285	COG0515	serine threonine protein kinase
C2H98_12310	COG1695	Transcriptional regulator
C2H98_12330	COG3279	Response regulator of the LytR AlgR family
C2H98_12340	COG3480	Lon protease (S16) C-terminal proteolytic domain
C2H98_12345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H98_12350	COG1794	racemase activity, acting on amino acids and derivatives
C2H98_12355	COG1785	Belongs to the alkaline phosphatase family
C2H98_12365	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H98_12370	COG2514	catechol 2,3-dioxygenase activity
C2H98_12375	COG1733	regulation of RNA biosynthetic process
C2H98_12380	COG0166	Belongs to the GPI family
C2H98_12400	COG2207	Transcriptional regulator
C2H98_12400	COG4753	response regulator
C2H98_12405	COG2972	Histidine kinase
C2H98_12425	COG3584	3D domain protein
C2H98_12425	COG1388	LysM domain
C2H98_12430	COG0456	acetyltransferase
C2H98_12440	COG2205	protein histidine kinase activity
C2H98_12445	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
C2H98_12450	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2H98_12460	COG1597	lipid kinase activity
C2H98_12480	COG1595	DNA-templated transcription, initiation
C2H98_12500	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2H98_12510	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2H98_12515	COG2720	vancomycin resistance protein
C2H98_12520	COG1846	Transcriptional regulator
C2H98_12525	COG1764	response to oxidative stress
C2H98_12530	COG5506	Protein of unknown function (DUF1694)
C2H98_12535	COG4851	CamS sex pheromone cAM373 precursor
C2H98_12540	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C2H98_12545	COG0210	DNA helicase
C2H98_12550	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
C2H98_12555	COG4496	protein, YerC YecD
C2H98_12560	COG1470	cell adhesion involved in biofilm formation
C2H98_12575	COG1028	Short-chain dehydrogenase reductase Sdr
C2H98_12580	COG0151	Belongs to the GarS family
C2H98_12585	COG0138	bifunctional purine biosynthesis protein purh
C2H98_12590	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2H98_12595	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C2H98_12600	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C2H98_12610	COG0047	phosphoribosylformylglycinamidine synthase activity
C2H98_12615	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2H98_12620	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C2H98_12625	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2H98_12630	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2H98_12635	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2H98_12645	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
C2H98_12690	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2H98_12710	COG1263	PTS System
C2H98_12710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H98_12710	COG2190	(PTS) system
C2H98_12715	COG3711	transcriptional antiterminator
C2H98_12720	COG2252	PERMEase
C2H98_12725	COG0574	Belongs to the PEP-utilizing enzyme family
C2H98_12725	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2H98_12730	COG0517	IMP dehydrogenase activity
C2H98_12735	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C2H98_12740	COG0730	response to heat
C2H98_12745	COG0519	Catalyzes the synthesis of GMP from XMP
C2H98_12745	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2H98_12750	COG1305	Transglutaminase-like
C2H98_12755	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
C2H98_12760	COG0714	Associated with various cellular activities
C2H98_12765	COG2310	stress, protein
C2H98_12770	COG3711	transcriptional antiterminator
C2H98_12775	COG2723	6-phospho-beta-galactosidase activity
C2H98_12780	COG1263	PTS System
C2H98_12780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H98_12780	COG2190	(PTS) system
C2H98_12790	COG1904	glucuronate isomerase
C2H98_12800	COG1312	Catalyzes the dehydration of D-mannonate
C2H98_12830	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C2H98_12835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H98_12840	COG2222	sugar isomerase
C2H98_12845	COG2188	Transcriptional regulator
C2H98_12850	COG0702	epimerase
C2H98_12865	COG1288	antiporter activity
C2H98_12870	COG1473	amidohydrolase
C2H98_12875	COG0583	DNA-binding transcription factor activity
C2H98_12885	COG2211	Major facilitator Superfamily
C2H98_12895	COG4294	response to UV
C2H98_12900	COG4294	response to UV
C2H98_12905	COG3871	stress protein (general stress protein 26)
C2H98_12910	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2H98_12920	COG1533	DNA photolyase activity
C2H98_12930	COG3842	ATPase activity
C2H98_12945	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C2H98_12960	COG0281	malic enzyme
C2H98_12970	COG4565	transcriptional regulatory protein
C2H98_12975	COG3290	protein histidine kinase activity
C2H98_12985	COG0733	neurotransmitter:sodium symporter activity
C2H98_12990	COG0840	transmembrane signaling receptor activity
C2H98_13005	COG0277	FAD linked oxidase domain protein
C2H98_13010	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C2H98_13015	COG0673	inositol 2-dehydrogenase activity
C2H98_13025	COG3716	PTS system mannose fructose sorbose family IID component
C2H98_13030	COG3715	PTS system
C2H98_13075	COG0346	lactoylglutathione lyase activity
C2H98_13085	COG0556	nucleotide-excision repair
C2H98_13100	COG0210	DNA helicase
C2H98_13135	COG4443	Transcriptional Coactivator p15 (PC4)
C2H98_13155	COG0582	viral genome integration into host DNA
C2H98_13165	COG0582	viral genome integration into host DNA
C2H98_13170	COG0459	protein refolding
C2H98_13175	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C2H98_13180	COG1266	CAAX protease self-immunity
C2H98_13190	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C2H98_13195	COG0315	cyclic pyranopterin monophosphate synthase activity
C2H98_13200	COG0488	(ABC) transporter
C2H98_13210	COG0456	acetyltransferase
C2H98_13215	COG1214	PFAM Peptidase M22, glycoprotease
C2H98_13220	COG0802	atpase or kinase
C2H98_13300	COG3091	SprT-like family
C2H98_13310	COG2183	response to ionizing radiation
C2H98_13315	COG2208	phosphoserine phosphatase activity
C2H98_13320	COG1191	sigma factor activity
C2H98_13325	COG2172	sigma factor antagonist activity
C2H98_13330	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H98_13335	COG2208	phosphoserine phosphatase activity
C2H98_13340	COG2172	sigma factor antagonist activity
C2H98_13345	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H98_13350	COG2337	Toxic component of a toxin-antitoxin (TA) module
C2H98_13355	COG0864	Transcriptional regulator
C2H98_13365	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C2H98_13370	COG0736	holo-[acyl-carrier-protein] synthase activity
C2H98_13375	COG0705	Rhomboid family
C2H98_13380	COG3428	Bacterial PH domain
C2H98_13385	COG3402	PFAM membrane-flanked domain
C2H98_13390	COG0513	Belongs to the DEAD box helicase family
C2H98_13400	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2H98_13420	COG2096	Adenosyltransferase
C2H98_13430	COG0588	phosphoglycerate mutase activity
C2H98_13435	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C2H98_13440	COG1492	cobalamin metabolic process
C2H98_13450	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C2H98_13455	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C2H98_13460	COG1120	ATPase activity
C2H98_13465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H98_13470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H98_13475	COG1489	DNA binding
C2H98_13485	COG0402	S-adenosylhomocysteine deaminase activity
C2H98_13490	COG2239	Acts as a magnesium transporter
C2H98_13495	COG0772	Belongs to the SEDS family
C2H98_13500	COG0783	Belongs to the Dps family
C2H98_13505	COG0569	domain protein
C2H98_13510	COG0668	transmembrane transport
C2H98_13515	COG2861	carbohydrate metabolic process
C2H98_13530	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2H98_13540	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C2H98_13545	COG1177	transmembrane transport
C2H98_13550	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2H98_13575	COG0242	peptide deformylase activity
C2H98_13580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2H98_13585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2H98_13590	COG5002	protein histidine kinase activity
C2H98_13590	COG3850	Histidine kinase
C2H98_13595	COG1940	carbohydrate kinase activity
C2H98_13600	COG0673	inositol 2-dehydrogenase activity
C2H98_13605	COG4607	ABC-type enterochelin transport system periplasmic component
C2H98_13610	COG4604	ABC transporter, ATP-binding protein
C2H98_13615	COG4605	iron ion homeostasis
C2H98_13620	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H98_13635	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2H98_13640	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2H98_13645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2H98_13650	COG0246	Mannitol dehydrogenase
C2H98_13655	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H98_13660	COG3711	transcriptional antiterminator
C2H98_13670	COG1253	flavin adenine dinucleotide binding
C2H98_13680	COG0628	permease
C2H98_13685	COG0129	dihydroxy-acid dehydratase activity
C2H98_13690	COG0667	Aldo Keto reductase
C2H98_13705	COG1120	ATPase activity
C2H98_13715	COG4608	Belongs to the ABC transporter superfamily
C2H98_13720	COG0791	NLP P60 protein
C2H98_13725	COG4948	Mandelate Racemase Muconate Lactonizing
C2H98_13730	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2H98_13735	COG4166	transmembrane transport
C2H98_13740	COG0444	Belongs to the ABC transporter superfamily
C2H98_13745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2H98_13750	COG0601	transmembrane transport
C2H98_13755	COG2362	D-Aminopeptidase
C2H98_13775	COG1959	2 iron, 2 sulfur cluster binding
C2H98_13780	COG0438	transferase activity, transferring glycosyl groups
C2H98_13785	COG1215	transferase activity, transferring glycosyl groups
C2H98_13790	COG3206	protein involved in exopolysaccharide biosynthesis
C2H98_13795	COG3307	-O-antigen
C2H98_13805	COG0438	transferase activity, transferring glycosyl groups
C2H98_13805	COG0297	glycogen (starch) synthase activity
C2H98_13810	COG2244	polysaccharide biosynthetic process
C2H98_13830	COG1122	ATPase activity
C2H98_13845	COG1252	NADH dehydrogenase
C2H98_13885	COG0725	ABC transporter, periplasmic molybdate-binding protein
C2H98_13890	COG4149	molybdate abc transporter
C2H98_13910	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H98_13935	COG1263	PTS System
C2H98_13935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H98_13935	COG2190	(PTS) system
C2H98_13945	COG3620	sequence-specific DNA binding
C2H98_13955	COG0659	secondary active sulfate transmembrane transporter activity
C2H98_13965	COG3386	PFAM SMP-30 Gluconolaconase
C2H98_13970	COG0017	Asparaginyl-tRNA synthetase
C2H98_13975	COG1657	PFAM Prenyltransferase squalene oxidase
C2H98_13990	COG2404	hydrolase activity, acting on ester bonds
C2H98_14005	COG1028	Short-chain dehydrogenase reductase Sdr
C2H98_14030	COG2814	Major facilitator Superfamily
C2H98_14035	COG1309	transcriptional regulator
C2H98_14050	COG5002	protein histidine kinase activity
C2H98_14075	COG0529	Catalyzes the synthesis of activated sulfate
C2H98_14080	COG2046	Belongs to the sulfate adenylyltransferase family
C2H98_14085	COG0306	phosphate transporter
C2H98_14090	COG0175	sulfate reduction
C2H98_14105	COG0583	DNA-binding transcription factor activity
C2H98_14110	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2H98_14115	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2H98_14125	COG1028	Short-chain dehydrogenase reductase Sdr
C2H98_14130	COG1874	Beta-galactosidase
C2H98_14135	COG3833	ABC-type maltose transport systems, permease component
C2H98_14140	COG1175	transmembrane transport
C2H98_14145	COG2182	Extracellular solute-binding protein
C2H98_14150	COG1609	Transcriptional regulator
C2H98_14160	COG1011	Hydrolase
C2H98_14185	COG0454	-acetyltransferase
C2H98_14195	COG1316	TRANSCRIPTIONal
C2H98_14205	COG1595	DNA-templated transcription, initiation
C2H98_14230	COG0456	acetyltransferase
C2H98_14240	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C2H98_14245	COG0492	ferredoxin-NADP+ reductase activity
C2H98_14250	COG1595	DNA-templated transcription, initiation
C2H98_14260	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2H98_14265	COG0519	Catalyzes the synthesis of GMP from XMP
C2H98_14270	COG2378	regulation of single-species biofilm formation
C2H98_14275	COG1114	Component of the transport system for branched-chain amino acids
C2H98_14285	COG2210	Belongs to the sulfur carrier protein TusA family
C2H98_14300	COG0730	response to heat
C2H98_14310	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2H98_14325	COG1120	ATPase activity
C2H98_14330	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H98_14335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H98_14340	COG4607	ABC-type enterochelin transport system periplasmic component
C2H98_14350	COG2807	transmembrane transport
C2H98_14365	COG1028	Short-chain dehydrogenase reductase Sdr
C2H98_14370	COG2807	transmembrane transport
C2H98_14375	COG3716	PTS system mannose fructose sorbose family IID component
C2H98_14385	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H98_14385	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H98_14390	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H98_14390	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H98_14405	COG0656	L-ascorbic acid biosynthetic process
C2H98_14425	COG3730	PTS system glucitol sorbitol-specific
C2H98_14430	COG1063	alcohol dehydrogenase
C2H98_14440	COG1012	belongs to the aldehyde dehydrogenase family
C2H98_14450	COG1733	regulation of RNA biosynthetic process
C2H98_14475	COG0642	Histidine kinase
C2H98_14480	COG0745	RESPONSE REGULATOR receiver
C2H98_14505	COG2205	protein histidine kinase activity
C2H98_14510	COG0745	RESPONSE REGULATOR receiver
C2H98_14525	COG0778	Nitroreductase
C2H98_14535	COG1846	Transcriptional regulator
C2H98_14560	COG1846	Transcriptional regulator
C2H98_14600	COG0463	Glycosyl transferase, family 2
C2H98_14610	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2H98_14615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2H98_14620	COG4856	YbbR-like protein
C2H98_14625	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C2H98_14630	COG5662	AntiSigma factor
C2H98_14635	COG1595	DNA-templated transcription, initiation
C2H98_14710	COG0726	polysaccharide deacetylase
C2H98_14720	COG0489	protein tyrosine kinase activity
C2H98_14725	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H98_14790	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C2H98_14800	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C2H98_14805	COG1122	ATPase activity
C2H98_14810	COG1122	ATPase activity
C2H98_14815	COG0203	ribosomal protein L17
C2H98_14820	COG0202	RNA polymerase activity
C2H98_14830	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C2H98_14835	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2H98_14840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C2H98_14845	COG0563	adenylate kinase activity
C2H98_14850	COG0201	protein transport
C2H98_14860	COG1841	ribosomal large subunit assembly
C2H98_14865	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C2H98_14870	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C2H98_14875	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C2H98_14900	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C2H98_14905	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C2H98_14910	COG0255	Belongs to the universal ribosomal protein uL29 family
C2H98_14915	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C2H98_14920	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C2H98_14925	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C2H98_14930	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C2H98_14935	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C2H98_14945	COG0088	Forms part of the polypeptide exit tunnel
C2H98_14950	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C2H98_14955	COG0051	transcription antitermination factor activity, RNA binding
C2H98_14960	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2H98_14970	COG0049	tRNA binding
C2H98_14975	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C2H98_14980	COG1358	cellular component organization or biogenesis
C2H98_14985	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C2H98_14995	COG2813	Specifically methylates the guanine in position
C2H98_15000	COG0222	ribosome binding
C2H98_15010	COG0081	regulation of translation
C2H98_15020	COG0250	Participates in transcription elongation, termination and antitermination
C2H98_15025	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2H98_15030	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C2H98_15040	COG3688	RNA-binding protein containing a PIN domain
C2H98_15045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2H98_15055	COG0215	cysteine-tRNA ligase activity
C2H98_15060	COG1045	serine acetyltransferase
C2H98_15065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2H98_15070	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C2H98_15075	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C2H98_15080	COG4956	integral membrane protein (PIN domain superfamily)
C2H98_15085	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C2H98_15090	COG0542	response to heat
C2H98_15095	COG3869	Catalyzes the specific phosphorylation of arginine residues in
C2H98_15100	COG3880	PFAM UvrB UvrC protein
C2H98_15185	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C2H98_15190	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2H98_15195	COG1396	sequence-specific DNA binding
C2H98_15200	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C2H98_15205	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2H98_15210	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2H98_15215	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2H98_15220	COG0512	Glutamine amidotransferase of anthranilate synthase
C2H98_15225	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2H98_15230	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2H98_15235	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C2H98_15240	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C2H98_15245	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2H98_15255	COG0037	tRNA processing
C2H98_15260	COG0515	serine threonine protein kinase
C2H98_15265	COG2304	oxidoreductase activity
C2H98_15270	COG2208	phosphoserine phosphatase activity
C2H98_15280	COG1098	S1 RNA binding domain
C2H98_15285	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C2H98_15300	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C2H98_15305	COG3956	TIGRFAM MazG family protein
C2H98_15310	COG2244	polysaccharide biosynthetic process
C2H98_15320	COG2188	Transcriptional regulator
C2H98_15325	COG2002	toxin-antitoxin pair type II binding
C2H98_15330	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2H98_15340	COG0193	aminoacyl-tRNA hydrolase activity
C2H98_15345	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C2H98_15350	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2H98_15355	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2H98_15360	COG2088	sporulation resulting in formation of a cellular spore
C2H98_15365	COG0251	oxidation-reduction process
C2H98_15370	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2H98_15375	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C2H98_15385	COG4466	Protein conserved in bacteria
C2H98_15395	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C2H98_15405	COG3584	3D domain protein
C2H98_15405	COG3583	domain protein
C2H98_15410	COG0084	hydrolase, TatD family'
C2H98_15420	COG2002	toxin-antitoxin pair type II binding
C2H98_15425	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C2H98_15430	COG2827	Endonuclease containing a URI domain
C2H98_15435	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C2H98_15440	COG4467	Involved in initiation control of chromosome replication
C2H98_15445	COG1774	PSP1 C-terminal conserved region
C2H98_15450	COG0470	DNA polymerase III
C2H98_15460	COG3870	Protein conserved in bacteria
C2H98_15470	COG1982	Orn Lys Arg decarboxylase major
C2H98_15515	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C2H98_15520	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C2H98_15535	COG0590	tRNA wobble adenosine to inosine editing
C2H98_15540	COG1335	isochorismatase
C2H98_15545	COG3858	chitin binding
C2H98_15545	COG1388	LysM domain
C2H98_15550	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2H98_15555	COG2022	thiamine diphosphate biosynthetic process
C2H98_15560	COG2104	thiamine diphosphate biosynthetic process
C2H98_15570	COG0352	thiamine-phosphate diphosphorylase activity
C2H98_15575	COG1428	Deoxynucleoside kinase
C2H98_15580	COG1428	Deoxynucleoside kinase
C2H98_15590	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C2H98_15595	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C2H98_15610	COG0516	GMP reductase activity
C2H98_15610	COG0517	IMP dehydrogenase activity
C2H98_15645	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2H98_15650	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C2H98_15655	COG0187	DNA topoisomerase II activity
C2H98_15665	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C2H98_15670	COG2501	S4 domain
C2H98_15675	COG0592	DNA-directed DNA polymerase activity
C2H98_15685	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C2H98_15690	COG0594	ribonuclease P activity
C2H98_15700	COG1847	R3H domain protein
C2H98_15720	COG1475	DNA binding
C2H98_15730	COG1192	Involved in chromosome partitioning
C2H98_15735	COG1475	DNA binding
C2H98_15750	COG0668	transmembrane transport
C2H98_15755	COG4481	Protein conserved in bacteria
C2H98_15760	COG0012	GTP binding
C2H98_15765	COG0438	transferase activity, transferring glycosyl groups
C2H98_15770	COG0360	Binds together with S18 to 16S ribosomal RNA
C2H98_15780	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C2H98_15785	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
C2H98_15790	COG0359	binds to the 23S rRNA
C2H98_15795	COG0305	Participates in initiation and elongation during chromosome replication
C2H98_15805	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2H98_15835	COG0745	RESPONSE REGULATOR receiver
C2H98_15840	COG5002	protein histidine kinase activity
C2H98_15845	COG4863	YycH protein
C2H98_15850	COG4853	Protein conserved in bacteria
C2H98_15855	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C2H98_15860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2H98_15870	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C2H98_15875	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C2H98_15880	COG0210	DNA helicase
C2H98_16005	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C2H98_16010	COG4443	Transcriptional Coactivator p15 (PC4)
C2H98_16050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H98_16055	COG0697	spore germination
C2H98_16065	COG1028	Short-chain dehydrogenase reductase Sdr
C2H98_16080	COG0725	ABC transporter, periplasmic molybdate-binding protein
C2H98_16085	COG4149	molybdate abc transporter
C2H98_16090	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C2H98_16095	COG1140	nitrate reductase beta subunit
C2H98_16100	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C2H98_16105	COG2181	nitrate reductase activity
C2H98_16115	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2H98_16120	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2H98_16125	COG0303	'Molybdopterin
C2H98_16130	COG0314	molybdopterin synthase activity
C2H98_16140	COG1763	Mo-molybdopterin cofactor biosynthetic process
C2H98_16145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2H98_16150	COG0746	molybdenum cofactor guanylyltransferase activity
C2H98_16155	COG0109	protoheme IX farnesyltransferase activity
C2H98_16160	COG2223	nitrite transmembrane transporter activity
C2H98_16185	COG0697	spore germination
C2H98_16190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H98_16200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H98_16205	COG0765	amino acid transport
C2H98_16210	COG1126	abc transporter atp-binding protein
C2H98_16220	COG2169	Transcriptional regulator
C2H98_16225	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C2H98_16235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H98_16240	COG0697	spore germination
C2H98_16250	COG5002	protein histidine kinase activity
C2H98_16255	COG0745	RESPONSE REGULATOR receiver
C2H98_16265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H98_16270	COG1696	Membrane protein involved in D-alanine export
C2H98_16275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2H98_16280	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
C2H98_16290	COG0733	neurotransmitter:sodium symporter activity
C2H98_16295	COG2814	Major facilitator Superfamily
C2H98_16300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2H98_16310	COG0765	amino acid transport
C2H98_16315	COG1126	abc transporter atp-binding protein
C2H98_16325	COG2824	Alkylphosphonate utilization operon protein PhnA
C2H98_16345	COG5002	protein histidine kinase activity
C2H98_16355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H98_16360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H98_16365	COG5566	PFAM Mor transcription activator
C2H98_16375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H98_16380	COG1279	arginine transmembrane transporter activity
C2H98_16385	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2H98_16395	COG1464	Belongs to the NlpA lipoprotein family
C2H98_16400	COG0579	oxidoreductase
C2H98_16405	COG3507	Belongs to the glycosyl hydrolase 43 family
C2H98_16410	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H98_16415	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H98_16425	COG2723	6-phospho-beta-galactosidase activity
C2H98_16430	COG3711	transcriptional antiterminator
C2H98_16430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H98_16435	COG4166	transmembrane transport
C2H98_16455	COG3634	alkyl hydroperoxide reductase activity
C2H98_16460	COG0450	alkyl hydroperoxide reductase
C2H98_16465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2H98_16475	COG4555	ABC transporter
C2H98_16495	COG1397	ADP-ribosylglycohydrolase
C2H98_16500	COG1994	Peptidase M50
C2H98_16505	COG5039	Polysaccharide pyruvyl transferase
C2H98_16515	COG1175	transmembrane transport
C2H98_16520	COG0395	ABC-type sugar transport system, permease component
C2H98_16530	COG3459	Glycosyltransferase 36 associated
C2H98_16535	COG1609	Transcriptional regulator
C2H98_16540	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C2H98_16545	COG3142	Participates in the control of copper homeostasis
C2H98_16550	COG0124	histidyl-tRNA synthetase
C2H98_16555	COG0582	viral genome integration into host DNA
C2H98_16570	COG2111	Na H antiporter
C2H98_16580	COG0651	ATP synthesis coupled electron transport
C2H98_16585	COG1863	multisubunit Na H antiporter MnhE subunit
C2H98_16590	COG2212	antiporter activity
C2H98_16595	COG1320	monovalent cation:proton antiporter activity
C2H98_16600	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2H98_16605	COG4989	oxidoreductase activity
C2H98_16610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2H98_16620	COG4166	transmembrane transport
C2H98_16625	COG0601	transmembrane transport
C2H98_16630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2H98_16635	COG0444	Belongs to the ABC transporter superfamily
C2H98_16640	COG4608	Belongs to the ABC transporter superfamily
C2H98_16650	COG2205	protein histidine kinase activity
C2H98_16650	COG2198	Histidine kinase
C2H98_16650	COG0784	Response regulator, receiver
C2H98_16655	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C2H98_16660	COG2208	phosphoserine phosphatase activity
C2H98_16695	COG2072	flavoprotein involved in K transport
C2H98_16725	COG2814	Major facilitator Superfamily
C2H98_16740	COG2755	lipolytic protein G-D-S-L family
C2H98_16745	COG2755	lipolytic protein G-D-S-L family
C2H98_16745	COG0657	acetylesterase activity
C2H98_16750	COG1904	glucuronate isomerase
C2H98_16755	COG2721	sulfolactate sulfo-lyase activity
C2H98_16760	COG1609	Transcriptional regulator
C2H98_16785	COG0559	Belongs to the binding-protein-dependent transport system permease family
C2H98_16795	COG0411	ABC transporter
C2H98_16805	COG3695	enzyme binding
C2H98_16810	COG0039	L-malate dehydrogenase activity
C2H98_16815	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C2H98_16820	COG4721	ABC-type cobalt transport system, permease component
C2H98_16825	COG1122	ATPase activity
C2H98_16835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H98_16835	COG1263	PTS System
C2H98_16840	COG2182	Extracellular solute-binding protein
C2H98_16845	COG1175	transmembrane transport
C2H98_16850	COG3833	ABC-type maltose transport systems, permease component
C2H98_16860	COG1554	hydrolase, family 65, central catalytic
C2H98_16865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2H98_16880	COG1609	Transcriptional regulator
C2H98_16895	COG1609	Transcriptional regulator
C2H98_16905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H98_16915	COG0534	Mate efflux family protein
C2H98_16920	COG0477	Major facilitator Superfamily
C2H98_16930	COG2508	Transcriptional regulator
C2H98_16980	COG0446	pyridine nucleotide-disulphide oxidoreductase
C2H98_16990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H98_16990	COG3711	transcriptional antiterminator
C2H98_16995	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H98_17000	COG2723	6-phospho-beta-galactosidase activity
C2H98_17005	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H98_17010	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2H98_17015	COG0385	Bile acid
C2H98_17025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2H98_17030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2H98_17045	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H98_17050	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H98_17055	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2H98_17060	COG1486	melibiose metabolic process
C2H98_17070	COG2508	Transcriptional regulator
C2H98_17070	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C2H98_17075	COG0686	Belongs to the AlaDH PNT family
C2H98_17080	COG1131	(ABC) transporter
C2H98_17095	COG2966	Psort location CytoplasmicMembrane, score
C2H98_17100	COG3610	response to peptide
C2H98_17105	COG1486	melibiose metabolic process
C2H98_17110	COG0492	ferredoxin-NADP+ reductase activity
C2H98_17115	COG2226	methyltransferase
C2H98_17120	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2H98_17125	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2H98_17130	COG4988	ABC transporter
C2H98_17135	COG1294	oxidase, subunit
C2H98_17140	COG1271	oxidase subunit
C2H98_17150	COG0561	phosphatase activity
C2H98_17165	COG1131	(ABC) transporter
C2H98_17185	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2H98_17190	COG0351	phosphomethylpyrimidine kinase
C2H98_17195	COG0314	molybdopterin synthase activity
C2H98_17205	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2H98_17225	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C2H98_17240	COG2363	Small membrane protein
C2H98_17255	COG0280	phosphate acetyltransferase
C2H98_17270	COG0477	Major facilitator Superfamily
C2H98_17275	COG4844	belongs to the
C2H98_17280	COG1078	dGTPase activity
C2H98_17285	COG3465	dGTPase activity
C2H98_17290	COG1942	4-Oxalocrotonate Tautomerase
C2H98_17295	COG1994	Peptidase M50
C2H98_17305	COG1193	negative regulation of DNA recombination
C2H98_17320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2H98_17325	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C2H98_17335	COG0791	NLP P60 protein
C2H98_17335	COG1388	LysM domain
C2H98_17335	COG3103	Sh3 type 3 domain protein
C2H98_17340	COG4506	Protein conserved in bacteria
C2H98_17345	COG0018	arginyl-trna synthetase
C2H98_17385	COG1668	transmembrane transport
C2H98_17390	COG4555	ABC transporter
C2H98_17395	COG3279	Response regulator of the LytR AlgR family
C2H98_17405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2H98_17415	COG3343	RNA polymerase activity
C2H98_17425	COG0504	CTP synthase activity
C2H98_17430	COG4821	SIS domain
C2H98_17435	COG2204	response regulator
C2H98_17440	COG0191	fructose-bisphosphate aldolase activity
C2H98_17450	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C2H98_17460	COG1435	thymidine kinase activity
C2H98_17470	COG1253	flavin adenine dinucleotide binding
C2H98_17475	COG1253	flavin adenine dinucleotide binding
C2H98_17480	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H98_17485	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C2H98_17500	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2H98_17505	COG1121	(ABC) transporter
C2H98_17510	COG1321	iron dependent repressor
C2H98_17510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2H98_17515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2H98_17520	COG0506	proline dehydrogenase activity
C2H98_17525	COG1012	belongs to the aldehyde dehydrogenase family
C2H98_17540	COG0009	L-threonylcarbamoyladenylate synthase
C2H98_17545	COG1971	Probably functions as a manganese efflux pump
C2H98_17555	COG0840	transmembrane signaling receptor activity
C2H98_17565	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C2H98_17570	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C2H98_17575	COG1404	Belongs to the peptidase S8 family
C2H98_17585	COG0356	it plays a direct role in the translocation of protons across the membrane
C2H98_17590	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C2H98_17595	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C2H98_17600	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C2H98_17610	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C2H98_17615	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C2H98_17620	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C2H98_17625	COG4836	Membrane
C2H98_17635	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2H98_17640	COG2385	sporulation resulting in formation of a cellular spore
C2H98_17650	COG0739	heme binding
C2H98_17655	COG1609	Transcriptional regulator
C2H98_17660	COG1077	Cell shape determining protein MreB Mrl
C2H98_17665	COG4786	Flagellar basal body rod
C2H98_17670	COG4786	Flagellar basal body rod
C2H98_17700	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2H98_17705	COG4715	Zinc finger, swim domain protein
C2H98_17715	COG1388	LysM domain
C2H98_17715	COG0791	NLP P60 protein
C2H98_17725	COG3011	Protein conserved in bacteria
C2H98_17730	COG0768	penicillin binding
C2H98_17735	COG2719	SpoVR family
C2H98_17745	COG1595	DNA-templated transcription, initiation
C2H98_17750	COG0460	homoserine dehydrogenase
C2H98_17770	COG1388	LysM domain
C2H98_17770	COG0791	NLP P60 protein
C2H98_17775	COG0697	spore germination
C2H98_17780	COG1028	Short-chain dehydrogenase reductase Sdr
C2H98_17785	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2H98_17810	COG1131	(ABC) transporter
C2H98_17815	COG0842	Transport permease protein
C2H98_17820	COG4585	Histidine kinase
C2H98_17825	COG2197	response regulator
C2H98_17835	COG1408	metallophosphoesterase
C2H98_17865	COG0025	NhaP-type Na H and K H
C2H98_17870	COG4191	Histidine kinase
C2H98_17875	COG1388	LysM domain
C2H98_17880	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2H98_17890	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C2H98_17900	COG0701	Predicted permease
C2H98_17905	COG1609	Transcriptional regulator
C2H98_17910	COG3458	cephalosporin-C deacetylase activity
C2H98_17920	COG2723	6-phospho-beta-galactosidase activity
C2H98_17925	COG1940	carbohydrate kinase activity
C2H98_17930	COG0667	Aldo Keto reductase
C2H98_17940	COG1309	transcriptional regulator
C2H98_17945	COG0596	Alpha beta hydrolase
C2H98_17950	COG2814	Major facilitator Superfamily
C2H98_17960	COG0673	inositol 2-dehydrogenase activity
C2H98_17970	COG2814	Major facilitator Superfamily
C2H98_17975	COG1566	PFAM secretion protein HlyD family protein
C2H98_17980	COG1846	Transcriptional regulator
C2H98_17985	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C2H98_17985	COG2199	diguanylate cyclase activity
C2H98_18000	COG1742	UPF0060 membrane protein
C2H98_18010	COG3706	GGDEF domain
C2H98_18015	COG2002	toxin-antitoxin pair type II binding
C2H98_18030	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H98_18035	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2H98_18040	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H98_18050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H98_18050	COG3711	transcriptional antiterminator
C2H98_18055	COG2190	(PTS) system
C2H98_18060	COG3711	transcriptional antiterminator
C2H98_18065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H98_18065	COG1263	PTS System
C2H98_18065	COG2190	(PTS) system
C2H98_18070	COG3119	arylsulfatase activity
C2H98_18095	COG1132	(ABC) transporter
C2H98_18100	COG1846	Transcriptional regulator
C2H98_18105	COG0789	Transcriptional regulator
C2H98_18105	COG4978	Transcriptional regulator
C2H98_18110	COG2814	Major facilitator Superfamily
C2H98_18125	COG1486	melibiose metabolic process
C2H98_18130	COG4209	transmembrane transport
C2H98_18135	COG0395	ABC-type sugar transport system, permease component
C2H98_18145	COG5578	integral membrane protein
C2H98_18155	COG0668	transmembrane transport
C2H98_18160	COG3944	biosynthesis protein
C2H98_18165	COG0489	protein tyrosine kinase activity
C2H98_18170	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C2H98_18175	COG1215	transferase activity, transferring glycosyl groups
C2H98_18180	COG0438	transferase activity, transferring glycosyl groups
C2H98_18190	COG0438	transferase activity, transferring glycosyl groups
C2H98_18195	COG0438	transferase activity, transferring glycosyl groups
C2H98_18230	COG0438	transferase activity, transferring glycosyl groups
C2H98_18250	COG1132	(ABC) transporter
C2H98_18255	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C2H98_18255	COG0662	Cupin 2, conserved barrel domain protein
C2H98_18265	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C2H98_18275	COG1396	sequence-specific DNA binding
C2H98_18285	COG3944	biosynthesis protein
C2H98_18290	COG0489	protein tyrosine kinase activity
C2H98_18295	COG4464	protein tyrosine phosphatase activity
C2H98_18300	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C2H98_18305	COG0463	Glycosyl transferase, family 2
C2H98_18310	COG0438	transferase activity, transferring glycosyl groups
C2H98_18320	COG1215	transferase activity, transferring glycosyl groups
C2H98_18345	COG1091	dTDP-4-dehydrorhamnose reductase activity
C2H98_18365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H98_18380	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2H98_18415	COG1609	Transcriptional regulator
C2H98_18420	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2H98_18425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H98_18430	COG1263	PTS System
C2H98_18430	COG2190	(PTS) system
C2H98_18430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H98_18460	COG0402	S-adenosylhomocysteine deaminase activity
C2H98_18490	COG0281	malic enzyme
C2H98_18495	COG0679	Auxin Efflux Carrier
C2H98_18505	COG2814	Major facilitator Superfamily
C2H98_18515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2H98_18520	COG0543	2 iron, 2 sulfur cluster binding
C2H98_18550	COG3764	Sortase (surface protein transpeptidase)
C2H98_18565	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2H98_18580	COG1609	Transcriptional regulator
C2H98_18590	COG4821	SIS domain
C2H98_18595	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2H98_18605	COG1940	carbohydrate kinase activity
C2H98_18615	COG3716	PTS system mannose fructose sorbose family IID component
C2H98_18630	COG1263	PTS System
C2H98_18630	COG2190	(PTS) system
C2H98_18630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H98_18645	COG2081	HI0933 family
C2H98_18665	COG1737	Transcriptional regulator
C2H98_18670	COG3420	alginic acid biosynthetic process
C2H98_18680	COG1694	Mazg nucleotide pyrophosphohydrolase
C2H98_18685	COG1609	Transcriptional regulator
C2H98_18695	COG0561	phosphatase activity
C2H98_18700	COG3711	transcriptional antiterminator
C2H98_18705	COG2190	(PTS) system
C2H98_18705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H98_18705	COG1263	PTS System
C2H98_18715	COG1309	transcriptional regulator
C2H98_18720	COG2814	Major facilitator Superfamily
C2H98_18725	COG4974	Belongs to the 'phage' integrase family
C2H98_18745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H98_18750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H98_18760	COG0745	RESPONSE REGULATOR receiver
C2H98_18780	COG1522	sequence-specific DNA binding
C2H98_18795	COG1414	Transcriptional regulator
C2H98_18800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H98_18805	COG0800	Aldolase
C2H98_18810	COG4948	Mandelate Racemase Muconate Lactonizing
C2H98_18815	COG2271	Major facilitator Superfamily
C2H98_18835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2H98_18845	COG0402	S-adenosylhomocysteine deaminase activity
C2H98_18850	COG0402	S-adenosylhomocysteine deaminase activity
C2H98_18855	COG1141	Ferredoxin
C2H98_18865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H98_18870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H98_18890	COG1402	creatininase
C2H98_18900	COG4821	SIS domain
C2H98_18915	COG1940	carbohydrate kinase activity
C2H98_18915	COG1846	Transcriptional regulator
C2H98_18930	COG3715	PTS system
C2H98_18935	COG3716	PTS system mannose fructose sorbose family IID component
C2H98_18940	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2H98_18950	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C2H98_18955	COG0745	RESPONSE REGULATOR receiver
C2H98_18960	COG2205	protein histidine kinase activity
C2H98_18965	COG1131	(ABC) transporter
C2H98_19005	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C2H98_19025	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H98_19025	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H98_19030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2H98_19040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2H98_19045	COG0800	Aldolase
C2H98_19050	COG2972	Histidine kinase
C2H98_19055	COG3279	Response regulator of the LytR AlgR family
C2H98_19065	COG4209	transmembrane transport
C2H98_19070	COG0395	ABC-type sugar transport system, permease component
C2H98_19085	COG0765	amino acid transport
C2H98_19090	COG1126	abc transporter atp-binding protein
C2H98_19100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H98_19105	COG2222	sugar isomerase
C2H98_19110	COG2188	Transcriptional regulator
C2H98_19115	COG1012	belongs to the aldehyde dehydrogenase family
C2H98_19125	COG0840	transmembrane signaling receptor activity
C2H98_19135	COG0165	Argininosuccinate lyase
C2H98_19145	COG1175	transmembrane transport
C2H98_19150	COG0395	ABC-type sugar transport system, permease component
C2H98_19155	COG2814	Major facilitator Superfamily
C2H98_19165	COG1846	Transcriptional regulator
C2H98_19170	COG3291	Pkd domain containing protein
C2H98_19170	COG4412	M6 family metalloprotease domain protein
C2H98_19185	COG4895	conserved protein (DUF2196)
C2H98_19200	COG0371	Dehydrogenase
C2H98_19205	COG0436	Aminotransferase
C2H98_19210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H98_19225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H98_19230	COG0765	amino acid transport
C2H98_19235	COG1126	abc transporter atp-binding protein
C2H98_19245	COG2079	MmgE PrpD family protein
C2H98_19250	COG0745	RESPONSE REGULATOR receiver
C2H98_19250	COG2972	Histidine kinase
C2H98_19255	COG3279	Response regulator of the LytR AlgR family
C2H98_19290	COG2160	L-arabinose isomerase activity
C2H98_19305	COG1609	Transcriptional regulator
C2H98_19320	COG0346	lactoylglutathione lyase activity
C2H98_19325	COG2720	vancomycin resistance protein
C2H98_19350	COG1940	carbohydrate kinase activity
C2H98_19360	COG1175	transmembrane transport
C2H98_19365	COG0395	ABC-type sugar transport system, permease component
C2H98_19395	COG2368	4-hydroxyphenylacetate
C2H98_19400	COG2188	Transcriptional regulator
C2H98_19405	COG2723	6-phospho-beta-galactosidase activity
C2H98_19410	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H98_19420	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2H98_19435	COG2153	protein acetylation
C2H98_19465	COG2340	Cysteine-rich secretory protein family
C2H98_19470	COG1316	TRANSCRIPTIONal
C2H98_19480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H98_19500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H98_19510	COG3279	Response regulator of the LytR AlgR family
C2H98_19515	COG2199	diguanylate cyclase activity
C2H98_19515	COG2200	EAL domain
C2H98_19520	COG2197	response regulator
C2H98_19525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H98_19530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H98_19535	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H98_19540	COG3250	beta-galactosidase activity
C2H98_19555	COG1609	Transcriptional regulator
C2H98_19575	COG1175	transmembrane transport
C2H98_19580	COG0395	ABC-type sugar transport system, permease component
C2H98_19590	COG3345	alpha-galactosidase
C2H98_19610	COG1988	membrane-bound metal-dependent
C2H98_19620	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C2H98_19625	COG3842	ATPase activity
C2H98_19630	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2H98_19635	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2H98_19655	COG2610	gluconate transmembrane transporter activity
C2H98_19660	COG1929	Belongs to the glycerate kinase type-1 family
C2H98_19665	COG3835	regulator
C2H98_19685	COG1263	PTS System
C2H98_19685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H98_19695	COG4753	response regulator
C2H98_19695	COG2207	Transcriptional regulator
C2H98_19700	COG1840	ABC-type Fe3 transport system, periplasmic component
C2H98_19705	COG3842	ATPase activity
C2H98_19710	COG1178	ABC-type Fe3 transport system permease component
C2H98_19715	COG1525	nuclease
C2H98_19720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H98_19720	COG2190	(PTS) system
C2H98_19720	COG1263	PTS System
C2H98_19725	COG4948	Mandelate Racemase Muconate Lactonizing
C2H98_19730	COG2188	Transcriptional regulator
C2H98_19740	COG4209	transmembrane transport
C2H98_19745	COG0395	ABC-type sugar transport system, permease component
C2H98_19750	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C2H98_19765	COG2972	Histidine kinase
C2H98_19770	COG4753	response regulator
C2H98_19770	COG2207	Transcriptional regulator
C2H98_19775	COG0778	Nitroreductase
C2H98_19780	COG1309	transcriptional regulator
C2H98_19785	COG0477	Major facilitator Superfamily
C2H98_19790	COG1028	Short-chain dehydrogenase reductase Sdr
C2H98_19795	COG2207	Transcriptional regulator
C2H98_19805	COG0395	ABC-type sugar transport system, permease component
C2H98_19820	COG2972	Histidine kinase
C2H98_19825	COG2207	Transcriptional regulator
C2H98_19825	COG4753	response regulator
C2H98_19845	COG0383	alpha-mannosidase activity
C2H98_19850	COG2814	Major facilitator Superfamily
C2H98_19855	COG1028	Short-chain dehydrogenase reductase Sdr
C2H98_19860	COG2124	cytochrome p450
C2H98_19895	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H98_19900	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H98_19900	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C2H98_19900	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H98_19905	COG0191	fructose-bisphosphate aldolase activity
C2H98_19915	COG1695	Transcriptional regulator
C2H98_19930	COG0840	transmembrane signaling receptor activity
C2H98_19930	COG5278	phosphoserine phosphatase activity
C2H98_19940	COG2188	Transcriptional regulator
C2H98_19945	COG2723	6-phospho-beta-galactosidase activity
C2H98_19950	COG1164	Oligoendopeptidase f
C2H98_19980	COG0561	phosphatase activity
C2H98_19990	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C2H98_20000	COG1115	amino acid carrier protein
C2H98_20005	COG0778	Nitroreductase
C2H98_20010	COG1053	succinate dehydrogenase
C2H98_20015	COG0656	L-ascorbic acid biosynthetic process
C2H98_20020	COG0300	oxidoreductase activity
C2H98_20025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H98_20025	COG1263	PTS System
C2H98_20030	COG1486	melibiose metabolic process
C2H98_20035	COG1737	Transcriptional regulator
C2H98_20060	COG4191	Histidine kinase
C2H98_20065	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C2H98_20075	COG0577	efflux transmembrane transporter activity
C2H98_20080	COG1136	(ABC) transporter
C2H98_20085	COG0642	Histidine kinase
C2H98_20090	COG0745	RESPONSE REGULATOR receiver
C2H98_20095	COG0840	transmembrane signaling receptor activity
C2H98_20100	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2H98_20110	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2H98_20115	COG2011	ABC-type metal ion transport system permease component
C2H98_20130	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2H98_20135	COG3339	Conserved Protein
C2H98_20150	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
C2H98_20155	COG0531	amino acid
C2H98_20170	COG0205	6-phosphofructokinase activity
C2H98_20175	COG2188	Transcriptional regulator
C2H98_20180	COG1737	Transcriptional regulator
C2H98_20185	COG0363	glucosamine-6-phosphate deaminase activity
C2H98_20190	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2H98_20195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2H98_20200	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2H98_20200	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C2H98_20215	COG3715	PTS system
C2H98_20220	COG3716	PTS system mannose fructose sorbose family IID component
C2H98_20230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2H98_20235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H98_20240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2H98_20245	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
C2H98_20250	COG2084	Dehydrogenase
C2H98_20255	COG0371	Dehydrogenase
C2H98_20260	COG1660	Displays ATPase and GTPase activities
C2H98_20265	COG0604	alcohol dehydrogenase
C2H98_20285	COG1012	belongs to the aldehyde dehydrogenase family
C2H98_20300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2H98_20305	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2H98_20310	COG1335	isochorismatase
C2H98_20315	COG2814	Major facilitator Superfamily
C2H98_20320	COG0840	transmembrane signaling receptor activity
C2H98_20325	COG4297	protein containing double-stranded beta helix domain
C2H98_20330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2H98_20335	COG0629	single-stranded DNA binding
C2H98_20345	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
C2H98_20350	COG0366	Alpha amylase catalytic
C2H98_20355	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2H98_20360	COG0346	lactoylglutathione lyase activity
C2H98_20370	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C2H98_20375	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C2H98_20385	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2H98_20390	COG4193	domain, Protein
C2H98_20395	COG1682	transport, permease protein
C2H98_20400	COG1134	teichoic acid transport
C2H98_20405	COG1442	glycosyl transferase family 8
C2H98_20405	COG1216	Glycosyl transferase, family 2
C2H98_20410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2H98_20415	COG2247	cell wall binding repeat
C2H98_20415	COG2385	sporulation resulting in formation of a cellular spore
C2H98_20420	COG1316	TRANSCRIPTIONal
C2H98_20425	COG1739	Uncharacterized protein family UPF0029
C2H98_20430	COG4585	Histidine kinase
C2H98_20435	COG2197	response regulator
C2H98_20440	COG1307	EDD domain protein, DegV family
C2H98_20455	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C2H98_20460	COG1040	competence protein
C2H98_20480	COG1516	flagellar protein fliS
C2H98_20490	COG1728	Protein conserved in bacteria
C2H98_20505	COG1256	bacterial-type flagellum assembly
C2H98_20505	COG4786	Flagellar basal body rod
C2H98_20510	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2H98_20515	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
C2H98_20520	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C2H98_20535	COG1086	Polysaccharide biosynthesis protein
C2H98_20555	COG1442	glycosyl transferase family 8
C2H98_20570	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
C2H98_20580	COG1028	Short-chain dehydrogenase reductase Sdr
C2H98_20595	COG2089	acid synthase
C2H98_20600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2H98_20605	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2H98_20615	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C2H98_20620	COG1516	flagellar protein fliS
C2H98_20630	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2H98_20640	COG1522	sequence-specific DNA binding
C2H98_20650	COG0601	transmembrane transport
C2H98_20665	COG0444	Belongs to the ABC transporter superfamily
C2H98_20670	COG4608	Belongs to the ABC transporter superfamily
C2H98_20675	COG0405	Gamma-glutamyltransferase
C2H98_20680	COG2059	Chromate
C2H98_20685	COG2059	Chromate
C2H98_20690	COG1802	Transcriptional regulator
C2H98_20705	COG3842	ATPase activity
C2H98_20710	COG1176	ABC-type spermidine putrescine transport system, permease component I
C2H98_20715	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C2H98_20740	COG0653	protein targeting
C2H98_20755	COG0463	Glycosyl transferase, family 2
C2H98_20775	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H98_20780	COG2884	Cell division ATP-binding protein ftsE
C2H98_20785	COG2177	Part of the ABC transporter FtsEX involved in
C2H98_20790	COG0739	heme binding
C2H98_20795	COG0640	Transcriptional regulator
C2H98_20800	COG2217	Heavy metal translocating P-type atpase
C2H98_20805	COG3546	catalase activity
C2H98_20810	COG3409	Peptidoglycan-binding domain 1 protein
C2H98_20810	COG0793	Belongs to the peptidase S41A family
C2H98_20815	COG1733	regulation of RNA biosynthetic process
C2H98_20820	COG2814	Major facilitator Superfamily
C2H98_20825	COG0656	L-ascorbic acid biosynthetic process
C2H98_20835	COG0698	ribose 5-phosphate isomerase
C2H98_20840	COG0205	6-phosphofructokinase activity
C2H98_20845	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2H98_20860	COG3414	Phosphotransferase system galactitol-specific IIB component
C2H98_20865	COG3414	Phosphotransferase system galactitol-specific IIB component
C2H98_20870	COG3775	system Galactitol-specific IIC component
C2H98_20875	COG1063	alcohol dehydrogenase
C2H98_20885	COG0698	ribose 5-phosphate isomerase
C2H98_20890	COG0205	6-phosphofructokinase activity
C2H98_20895	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2H98_20900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2H98_20905	COG1271	oxidase subunit
C2H98_20910	COG1294	oxidase, subunit
C2H98_20915	COG4988	ABC transporter
C2H98_20920	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2H98_20925	COG2030	dehydratase
C2H98_20930	COG1053	succinate dehydrogenase
C2H98_20955	COG0281	malic enzyme
C2H98_20960	COG2233	PERMEase
C2H98_20965	COG2508	Transcriptional regulator
C2H98_20970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2H98_20975	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C2H98_20990	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C2H98_21000	COG1595	DNA-templated transcription, initiation
C2H98_21015	COG1012	belongs to the aldehyde dehydrogenase family
C2H98_21015	COG1454	alcohol dehydrogenase
C2H98_21030	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H98_21035	COG4897	Protein conserved in bacteria
C2H98_21040	COG0556	nucleotide-excision repair
C2H98_21045	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C2H98_21050	COG3595	metallopeptidase activity
C2H98_21055	COG1950	PFAM Membrane protein of
C2H98_21070	COG0546	phosphoglycolate phosphatase activity
C2H98_21075	COG0110	maltose O-acetyltransferase activity
C2H98_21080	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C2H98_21085	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C2H98_21090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C2H98_21095	COG0131	Imidazoleglycerol-phosphate dehydratase
C2H98_21100	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C2H98_21105	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C2H98_21110	COG0107	imidazoleglycerol-phosphate synthase activity
C2H98_21115	COG0140	phosphoribosyl-ATP diphosphatase activity
C2H98_21115	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C2H98_21120	COG0457	Tetratricopeptide repeat
C2H98_21130	COG0492	ferredoxin-NADP+ reductase activity
C2H98_21145	COG1051	belongs to the nudix hydrolase family
C2H98_21150	COG1660	Displays ATPase and GTPase activities
C2H98_21155	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C2H98_21165	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H98_21205	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C2H98_21220	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2H98_21225	COG1647	Serine aminopeptidase, S33
C2H98_21230	COG0557	exoribonuclease II activity
C2H98_21235	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C2H98_21245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H98_21245	COG3711	transcriptional antiterminator
C2H98_21260	COG3775	system Galactitol-specific IIC component
C2H98_21265	COG1063	alcohol dehydrogenase
C2H98_21275	COG1012	belongs to the aldehyde dehydrogenase family
C2H98_21285	COG1653	transport
C2H98_21290	COG1175	transmembrane transport
C2H98_21295	COG0395	ABC-type sugar transport system, permease component
C2H98_21310	COG1126	abc transporter atp-binding protein
C2H98_21315	COG0765	amino acid transport
C2H98_21340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H98_21355	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C2H98_21360	COG2188	Transcriptional regulator
C2H98_21365	COG0789	Transcriptional regulator
C2H98_21380	COG1802	Transcriptional regulator
C2H98_21390	COG2608	mercury ion transmembrane transporter activity
C2H98_21395	COG2217	Heavy metal translocating P-type atpase
C2H98_21405	COG2207	Transcriptional regulator
C2H98_21410	COG1486	melibiose metabolic process
C2H98_21415	COG1653	transport
C2H98_21420	COG1175	transmembrane transport
C2H98_21425	COG0395	ABC-type sugar transport system, permease component
C2H98_21430	COG0656	L-ascorbic acid biosynthetic process
C2H98_21435	COG0753	catalase activity
C2H98_21440	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2H98_21445	COG0710	3-dehydroquinate dehydratase activity
C2H98_21450	COG1012	belongs to the aldehyde dehydrogenase family
C2H98_21510	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H98_21515	COG5577	PFAM Coat F domain
C2H98_21525	COG5578	integral membrane protein
C2H98_21530	COG2972	Histidine kinase
C2H98_21535	COG4753	response regulator
C2H98_21535	COG2207	Transcriptional regulator
C2H98_21540	COG1653	transport
C2H98_21545	COG1175	transmembrane transport
C2H98_21550	COG0395	ABC-type sugar transport system, permease component
C2H98_21555	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C2H98_21560	COG1874	Beta-galactosidase
C2H98_21570	COG1609	Transcriptional regulator
C2H98_21575	COG0488	(ABC) transporter
C2H98_21585	COG1283	sodium-dependent phosphate transmembrane transporter activity
C2H98_21590	COG3764	Sortase (surface protein transpeptidase)
C2H98_21600	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C2H98_21605	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
C2H98_21610	COG1733	regulation of RNA biosynthetic process
C2H98_21615	COG1609	Transcriptional regulator
C2H98_21620	COG0366	Alpha amylase catalytic
C2H98_21630	COG2050	protein possibly involved in aromatic compounds catabolism
C2H98_21635	COG1846	Transcriptional regulator
C2H98_21640	COG1033	growth of symbiont in host cell
C2H98_21640	COG2409	Drug exporters of the RND superfamily
C2H98_21645	COG0628	permease
C2H98_21650	COG1968	undecaprenyl-diphosphatase activity
C2H98_21670	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2H98_21685	COG0544	peptidyl-prolyl cis-trans isomerase activity
C2H98_21690	COG3118	belongs to the thioredoxin family
C2H98_21695	COG1132	(ABC) transporter
C2H98_21700	COG1132	(ABC) transporter
C2H98_21720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H98_21725	COG0765	amino acid transport
C2H98_21730	COG1126	abc transporter atp-binding protein
C2H98_21740	COG0840	transmembrane signaling receptor activity
C2H98_21745	COG0772	Belongs to the SEDS family
C2H98_21755	COG5577	PFAM Coat F domain
C2H98_21770	COG1024	Enoyl-CoA hydratase
C2H98_21770	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2H98_21775	COG1960	acyl-CoA dehydrogenase activity
C2H98_21780	COG1393	Belongs to the ArsC family
C2H98_21785	COG0509	glycine decarboxylation via glycine cleavage system
C2H98_21790	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C2H98_21795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H98_21805	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2H98_21810	COG2011	ABC-type metal ion transport system permease component
C2H98_21815	COG1464	Belongs to the NlpA lipoprotein family
C2H98_21820	COG0396	ATPase activity
C2H98_21825	COG0719	Fe-S assembly protein
C2H98_21830	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2H98_21835	COG0822	iron-sulfur transferase activity
C2H98_21840	COG0719	Fe-S assembly protein
C2H98_21845	COG1940	carbohydrate kinase activity
C2H98_21855	COG0346	lactoylglutathione lyase activity
C2H98_21860	COG0110	maltose O-acetyltransferase activity
C2H98_21865	COG0561	phosphatase activity
C2H98_21870	COG1414	Transcriptional regulator
C2H98_21885	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
C2H98_21890	COG1028	Short-chain dehydrogenase reductase Sdr
C2H98_21895	COG1801	Protein of unknown function DUF72
C2H98_21900	COG0737	Belongs to the 5'-nucleotidase family
C2H98_21905	COG3377	Domain of unknown function (DUF1805)
C2H98_21915	COG0739	heme binding
C2H98_21920	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C2H98_21925	COG4470	Protein conserved in bacteria
C2H98_21930	COG3287	FIST C domain
C2H98_21930	COG2199	diguanylate cyclase activity
C2H98_21930	COG2200	EAL domain
C2H98_21935	COG2445	Protein of unknown function DUF86
C2H98_21940	COG0647	UMP catabolic process
C2H98_21945	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2H98_21950	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2H98_21955	COG0460	homoserine dehydrogenase
C2H98_21960	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2H98_21965	COG0083	homoserine kinase activity
C2H98_21970	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C2H98_21975	COG4837	Protein of unknown function (DUF1462)
C2H98_21980	COG1252	NADH dehydrogenase
C2H98_21985	COG4844	belongs to the
C2H98_21995	COG0316	Belongs to the HesB IscA family
C2H98_22000	COG0492	ferredoxin-NADP+ reductase activity
C2H98_22005	COG3584	3D domain protein
C2H98_22010	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
C2H98_22015	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2H98_22020	COG3243	poly(R)-hydroxyalkanoic acid synthase
C2H98_22030	COG1028	Short-chain dehydrogenase reductase Sdr
C2H98_22060	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2H98_22080	COG1320	monovalent cation:proton antiporter activity
C2H98_22085	COG2212	antiporter activity
C2H98_22090	COG1863	multisubunit Na H antiporter MnhE subunit
C2H98_22095	COG0651	ATP synthesis coupled electron transport
C2H98_22100	COG1006	Multisubunit Na H antiporter MnhC subunit
C2H98_22105	COG2111	Na H antiporter
C2H98_22110	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2H98_22110	COG2111	Na H antiporter
C2H98_22120	COG5018	Exonuclease
C2H98_22130	COG2032	superoxide dismutase activity
C2H98_22135	COG1914	H( )-stimulated, divalent metal cation uptake system
C2H98_22145	COG1464	Belongs to the NlpA lipoprotein family
C2H98_22150	COG2011	ABC-type metal ion transport system permease component
C2H98_22155	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2H98_22165	COG1522	sequence-specific DNA binding
C2H98_22170	COG0436	Aminotransferase
C2H98_22175	COG1098	S1 RNA binding domain
C2H98_22180	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2H98_22185	COG2155	Conserved Protein
C2H98_22190	COG1979	alcohol dehydrogenase
C2H98_22205	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2H98_22210	COG1309	transcriptional regulator
C2H98_22215	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2H98_22215	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2H98_22220	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2H98_22220	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2H98_22230	COG2059	Chromate
C2H98_22235	COG2059	Chromate
C2H98_22255	COG3729	General stress protein
C2H98_22265	COG0778	Nitroreductase
C2H98_22270	COG1028	Short-chain dehydrogenase reductase Sdr
C2H98_22275	COG0604	alcohol dehydrogenase
C2H98_22290	COG5002	protein histidine kinase activity
C2H98_22310	COG1285	pathogenesis
C2H98_22450	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2H98_22455	COG0297	glycogen (starch) synthase activity
C2H98_22460	COG0058	SHG alpha-glucan phosphorylase activity
C2H98_22465	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2H98_22470	COG1169	isochorismate synthase
C2H98_22480	COG0596	Alpha beta hydrolase
C2H98_22485	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C2H98_22505	COG0288	reversible hydration of carbon dioxide
C2H98_22510	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C2H98_22520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2H98_22535	COG0494	nUDIX hydrolase
C2H98_22540	COG1506	peptidase
C2H98_22550	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C2H98_22555	COG0367	asparagine synthase
C2H98_22560	COG4990	cell redox homeostasis
C2H98_22565	COG2267	carboxylic ester hydrolase activity
C2H98_22575	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C2H98_22580	COG1242	4 iron, 4 sulfur cluster binding
C2H98_22595	COG2814	Major facilitator Superfamily
C2H98_22600	COG0406	alpha-ribazole phosphatase activity
C2H98_22605	COG0154	amidase activity
C2H98_22610	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
C2H98_22620	COG0495	leucyl-tRNA aminoacylation
C2H98_22625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2H98_22635	COG2081	HI0933 family
C2H98_22640	COG2244	polysaccharide biosynthetic process
C2H98_22645	COG1187	pseudouridine synthase activity
C2H98_22650	COG1349	DNA-binding transcription factor activity
C2H98_22660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2H98_22670	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C2H98_22680	COG1523	belongs to the glycosyl hydrolase 13 family
C2H98_22685	COG0510	thiamine kinase activity
C2H98_22695	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C2H98_22700	COG5584	Small secreted protein
C2H98_22705	COG1363	Peptidase, m42
C2H98_22710	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
C2H98_22715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H98_22720	COG4848	Belongs to the UPF0354 family
C2H98_22725	COG1674	ftsk spoiiie
C2H98_22730	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2H98_22735	COG2309	aminopeptidase activity
C2H98_22740	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
C2H98_22745	COG4980	gas vesicle protein
C2H98_22750	COG3118	belongs to the thioredoxin family
C2H98_22755	COG0849	cell division
C2H98_22760	COG1605	Chorismate mutase
C2H98_22760	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C2H98_22785	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C2H98_22790	COG2203	Gaf domain
C2H98_22790	COG2199	diguanylate cyclase activity
C2H98_22795	COG1956	GAF domain-containing protein
C2H98_22800	COG1309	transcriptional regulator
C2H98_22805	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C2H98_22810	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
C2H98_22815	COG1104	cysteine desulfurase activity
C2H98_22820	COG0301	tRNA thio-modification
C2H98_22830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2H98_22835	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C2H98_22840	COG2962	Rard protein
C2H98_22845	COG0616	signal peptide processing
C2H98_22850	COG1714	RDD family
C2H98_22860	COG3874	Sporulation protein YtfJ
C2H98_22865	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C2H98_22870	COG0827	DNA restriction-modification system
C2H98_22885	COG3973	AAA domain
C2H98_22890	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2H98_22895	COG0137	argininosuccinate synthase activity
C2H98_22900	COG0165	Argininosuccinate lyase
C2H98_22905	COG0589	response to stress
C2H98_22915	COG0006	proline dipeptidase activity
C2H98_22925	COG4109	DRTGG domain
C2H98_22930	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C2H98_22945	COG0587	DNA-directed DNA polymerase activity
C2H98_22950	COG2186	Transcriptional regulator
C2H98_22955	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C2H98_22960	COG0825	malonyl-CoA metabolic process
C2H98_22975	COG3030	protein affecting phage T7 exclusion by the F plasmid
C2H98_22980	COG2972	Histidine kinase
C2H98_22985	COG2207	Transcriptional regulator
C2H98_22990	COG1653	transport
C2H98_22995	COG1175	transmembrane transport
C2H98_23005	COG5578	integral membrane protein
C2H98_23010	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2H98_23015	COG4209	transmembrane transport
C2H98_23020	COG0395	ABC-type sugar transport system, permease component
C2H98_23035	COG1028	Short-chain dehydrogenase reductase Sdr
C2H98_23080	COG0628	permease
C2H98_23085	COG2707	UPF0756 membrane protein
C2H98_23090	COG0372	Belongs to the citrate synthase family
C2H98_23095	COG0538	isocitrate dehydrogenase activity
C2H98_23100	COG0039	L-malate dehydrogenase activity
C2H98_23105	COG0745	RESPONSE REGULATOR receiver
C2H98_23110	COG5002	protein histidine kinase activity
C2H98_23115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2H98_23115	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2H98_23120	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C2H98_23125	COG1971	Probably functions as a manganese efflux pump
C2H98_23135	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C2H98_23140	COG3611	Membrane attachment protein
C2H98_23145	COG1484	DNA-dependent DNA replication
C2H98_23160	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2H98_23165	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C2H98_23175	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C2H98_23180	COG3326	Membrane
C2H98_23195	COG1363	Peptidase, m42
C2H98_23200	COG0628	permease
C2H98_23205	COG1940	carbohydrate kinase activity
C2H98_23210	COG2115	Belongs to the xylose isomerase family
C2H98_23215	COG1070	Carbohydrate kinase
C2H98_23225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2H98_23230	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C2H98_23235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2H98_23235	COG0072	phenylalanine-tRNA ligase activity
C2H98_23245	COG1175	transmembrane transport
C2H98_23250	COG0395	ABC-type sugar transport system, permease component
C2H98_23260	COG1940	carbohydrate kinase activity
C2H98_23265	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
C2H98_23275	COG1796	DNA polymerase
C2H98_23275	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C2H98_23285	COG3766	membrane
C2H98_23290	COG0318	PFAM AMP-dependent synthetase and ligase
C2H98_23295	COG2086	electron transfer activity
C2H98_23300	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C2H98_23305	COG3118	belongs to the thioredoxin family
C2H98_23320	COG1719	4-vinyl reductase, 4VR
C2H98_23325	COG2009	succinate dehydrogenase
C2H98_23330	COG1053	succinate dehydrogenase
C2H98_23335	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2H98_23345	COG2197	response regulator
C2H98_23350	COG1846	Transcriptional regulator
C2H98_23355	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C2H98_23360	COG5401	PFAM Sporulation and spore germination
C2H98_23375	COG0622	Phosphoesterase
C2H98_23530	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2H98_23530	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2H98_23555	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C2H98_23565	COG1780	Probably involved in ribonucleotide reductase function
C2H98_23570	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2H98_23575	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2H98_23590	COG0756	dUTP diphosphatase activity
C2H98_23600	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
C2H98_23615	COG0270	DNA (cytosine-5-)-methyltransferase activity
C2H98_23760	COG1388	LysM domain
C2H98_23760	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2H98_23815	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
C2H98_23825	COG0028	Belongs to the TPP enzyme family
C2H98_23830	COG0440	acetolactate synthase activity
C2H98_23835	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C2H98_23840	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2H98_23845	COG0473	3-isopropylmalate dehydrogenase activity
C2H98_23850	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C2H98_23855	COG0066	3-isopropylmalate dehydratase activity
C2H98_23865	COG0544	peptidyl-prolyl cis-trans isomerase activity
C2H98_23875	COG1067	ATP-dependent peptidase activity
C2H98_23875	COG0470	DNA polymerase III
C2H98_23880	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2H98_23885	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C2H98_23900	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2H98_23905	COG0181	hydroxymethylbilane synthase activity
C2H98_23915	COG0113	porphobilinogen synthase activity
C2H98_23920	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2H98_23925	COG1116	anion transmembrane transporter activity
C2H98_23930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2H98_23940	COG1649	PFAM Uncharacterised BCR, COG1649
C2H98_23940	COG0726	polysaccharide deacetylase
C2H98_23945	COG1388	LysM domain
C2H98_23945	COG1388	LysM domain
C2H98_23950	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2H98_23955	COG0525	valine-tRNA ligase activity
C2H98_23960	COG0285	dihydrofolate synthase activity
C2H98_23965	COG3706	GGDEF domain
C2H98_24005	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2H98_24025	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C2H98_24055	COG0424	maF-like protein
C2H98_24060	COG2003	Belongs to the UPF0758 family
C2H98_24065	COG1077	Cell shape determining protein MreB Mrl
C2H98_24070	COG1792	Involved in formation and maintenance of cell shape
C2H98_24075	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C2H98_24080	COG0850	regulation of cytokinetic process
C2H98_24085	COG2894	cell division
C2H98_24090	COG0739	heme binding
C2H98_24095	COG1994	Peptidase M50
C2H98_24100	COG1530	ribonuclease E activity
C2H98_24105	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C2H98_24110	COG2868	ribosomal protein
C2H98_24115	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C2H98_24120	COG3290	protein histidine kinase activity
C2H98_24125	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C2H98_24130	COG4492	Belongs to the UPF0735 family
C2H98_24135	COG0077	Prephenate dehydratase
C2H98_24140	COG1827	regulation of RNA biosynthetic process
C2H98_24185	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C2H98_24195	COG1862	Preprotein translocase
C2H98_24205	COG2323	membrane
C2H98_24210	COG2244	polysaccharide biosynthetic process
C2H98_24220	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2H98_24220	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2H98_24225	COG5416	Lipopolysaccharide assembly protein A domain
C2H98_24230	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C2H98_24230	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2H98_24235	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2H98_24240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2H98_24250	COG4991	sh3 domain protein
C2H98_24250	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H98_24250	COG3103	Sh3 type 3 domain protein
C2H98_24255	COG0124	histidyl-tRNA synthetase
C2H98_24260	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C2H98_24265	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2H98_24275	COG1725	Transcriptional regulator
C2H98_24280	COG1131	(ABC) transporter
C2H98_24285	COG1131	(ABC) transporter
C2H98_24290	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C2H98_24295	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2H98_24310	COG3833	ABC-type maltose transport systems, permease component
C2H98_24325	COG4948	Mandelate Racemase Muconate Lactonizing
C2H98_24335	COG1473	amidohydrolase
C2H98_24340	COG2364	Membrane
C2H98_24345	COG1959	2 iron, 2 sulfur cluster binding
C2H98_24350	COG1104	cysteine desulfurase activity
C2H98_24365	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2H98_24380	COG0628	permease
C2H98_24390	COG4472	Bacterial protein of unknown function (DUF965)
C2H98_24400	COG3906	Belongs to the UPF0473 family
C2H98_24405	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2H98_24425	COG0572	uridine kinase
C2H98_24430	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2H98_24435	COG0768	penicillin binding
C2H98_24450	COG2226	methyltransferase
C2H98_24455	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2H98_24460	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2H98_24465	COG0626	cystathionine gamma-synthase activity
C2H98_24475	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2H98_24480	COG0572	uridine kinase
C2H98_24485	COG4977	sequence-specific DNA binding
C2H98_24490	COG0673	inositol 2-dehydrogenase activity
C2H98_24500	COG0673	inositol 2-dehydrogenase activity
C2H98_24545	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
C2H98_24560	COG2350	Protein conserved in bacteria
C2H98_24580	COG3677	Transposase
C2H98_24625	COG1876	peptidase activity
C2H98_24630	COG3409	Peptidoglycan-binding domain 1 protein
C2H98_24630	COG3773	Cell wall hydrolase
C2H98_24700	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2H98_24720	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H98_24735	COG1183	phosphatidylcholine synthase activity
C2H98_24740	COG0688	phosphatidylethanolamine metabolic process
C2H98_24750	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
C2H98_24755	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C2H98_24765	COG1534	Rna-binding protein
C2H98_24770	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C2H98_24775	COG1713	HD superfamily hydrolase involved in NAD metabolism
C2H98_24780	COG0799	negative regulation of ribosome biogenesis
C2H98_24785	COG2226	methyltransferase
C2H98_24790	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2H98_24795	COG1596	polysaccharide export
C2H98_24795	COG1555	photosystem II stabilization
C2H98_24800	COG2131	deaminase
C2H98_24805	COG0658	competence protein
C2H98_24805	COG2333	competence protein COMEC
C2H98_24810	COG1466	dna polymerase III delta subunit
C2H98_24815	COG0268	Binds directly to 16S ribosomal RNA
C2H98_24830	COG0481	GTPase activity
C2H98_24835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2H98_24840	COG1420	regulation of RNA biosynthetic process
C2H98_24845	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C2H98_24850	COG0443	Heat shock 70 kDa protein
C2H98_24860	COG2264	protein methyltransferase activity
C2H98_24865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2H98_24870	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2H98_24875	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C2H98_24880	COG1917	Cupin 2, conserved barrel domain protein
C2H98_24880	COG2207	Transcriptional regulator
C2H98_24885	COG1132	(ABC) transporter
C2H98_24890	COG1132	(ABC) transporter
C2H98_24895	COG1283	sodium-dependent phosphate transmembrane transporter activity
C2H98_24900	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C2H98_24905	COG1610	YqeY-like protein
C2H98_24910	COG1030	water channel activity
C2H98_24915	COG4864	UPF0365 protein
C2H98_24935	COG1702	phosphate starvation-inducible protein PhoH
C2H98_24940	COG1480	7TM receptor with intracellular HD hydrolase
C2H98_24950	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2H98_24955	COG0295	cytidine deaminase activity
C2H98_24960	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C2H98_24970	COG1381	Involved in DNA repair and RecF pathway recombination
C2H98_24985	COG0751	glycine-tRNA ligase activity
C2H98_24990	COG0517	IMP dehydrogenase activity
C2H98_25000	COG1671	Belongs to the UPF0178 family
C2H98_25005	COG0358	DNA primase activity
C2H98_25010	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2H98_25020	COG2384	SAM-dependent methyltransferase
C2H98_25025	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2H98_25030	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C2H98_25040	COG0513	Belongs to the DEAD box helicase family
C2H98_25045	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C2H98_25055	COG0735	belongs to the Fur family
C2H98_25060	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
C2H98_25070	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C2H98_25085	COG5521	maltodextrose utilization protein MalA
C2H98_25090	COG2839	Protein conserved in bacteria
C2H98_25095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2H98_25105	COG0477	Major facilitator Superfamily
C2H98_25120	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2H98_25125	COG0573	inorganic phosphate transmembrane transporter activity
C2H98_25130	COG0581	inorganic phosphate transmembrane transporter activity
C2H98_25135	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2H98_25140	COG0704	Plays a role in the regulation of phosphate uptake
C2H98_25170	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C2H98_25175	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2H98_25190	COG2318	DinB family
C2H98_25195	COG0457	Tetratricopeptide repeat
C2H98_25195	COG0705	Rhomboid family
C2H98_25210	COG1940	carbohydrate kinase activity
C2H98_25215	COG1368	sulfuric ester hydrolase activity
C2H98_25230	COG0011	TIGRFAM Protein of
C2H98_25235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H98_25245	COG2072	flavoprotein involved in K transport
C2H98_25260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2H98_25265	COG1459	type II secretion system
C2H98_25270	COG4537	Required for transformation and DNA binding
C2H98_25305	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2H98_25310	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C2H98_25315	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2H98_25320	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2H98_25325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2H98_25330	COG0095	Lipoate-protein ligase