locus-tag class description DB29_00004 ENOG4105F2Z 3-oxoadipate enol-lactonase DB29_00009 ENOG4105DA5 (ABC) transporter DB29_00016 ENOG4105U3E Transcriptional regulator DB29_00017 ENOG41086D8 Transcriptional regulator DB29_00018 ENOG4105C8J )-transporter DB29_00020 ENOG4105VG1 fes assembly suf system protein DB29_00022 ENOG4108RNG Permease of the drug metabolite transporter DB29_00026 ENOG4105CGK Exodeoxyribonuclease III DB29_00027 ENOG4105BZC d-serine deaminase DB29_00028 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase DB29_00029 ENOG4108WBH protein TIM barrel DB29_00031 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) DB29_00035 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) DB29_00036 ENOG4105C28 cystathionine DB29_00038 ENOG4105DEN Luciferase family DB29_00041 ENOG4105DEN Luciferase family DB29_00045 ENOG4108URH decarboxylase DB29_00046 ENOG4108VX5 3-methyladenine DNA glycosylase DB29_00047 ENOG4108W7F transporter, permease DB29_00048 ENOG4108JJB ABC transporter DB29_00050 ENOG4105U0R haloacid dehalogenase-like hydrolase DB29_00051 ENOG4105CM2 brancheD-chain amino acid aminotransferase DB29_00054 ENOG41069ER domain protein DB29_00055 ENOG41069ER domain protein DB29_00057 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) DB29_00059 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase DB29_00062 ENOG41082BV acetyltransferase DB29_00065 ENOG4105E0Y RtcB Protein DB29_00067 ENOG4108Z5K methylglyoxal synthase DB29_00068 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) DB29_00069 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase DB29_00070 ENOG4108JYZ YitT family DB29_00071 ENOG4105C2C drug resistance transporter, Bcr CflA DB29_00075 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit DB29_00076 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) DB29_00080 ENOG41068YB TPR repeat-containing protein DB29_00081 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase DB29_00083 ENOG4105CIH Imidazole acetol-phosphate transaminase DB29_00084 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) DB29_00085 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) DB29_00087 ENOG4105DK0 Indole-3-glycerol phosphate synthase DB29_00088 ENOG4108I0Q anthranilate phosphoribosyltransferase DB29_00090 ENOG4105KHN chorismate mutase DB29_00091 ENOG4105D49 3-dehydroquinate synthase DB29_00092 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase DB29_00093 ENOG4105BZU Histidine kinase DB29_00095 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) DB29_00096 ENOG4105EAH synthase DB29_00098 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) DB29_00099 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DB29_00100 ENOG4105XXQ heptaprenyl diphosphate synthase component I DB29_00101 ENOG4105WP2 Tryptophan RNA-binding attenuator protein DB29_00102 ENOG4105EUJ GTP cyclohydrolase i DB29_00103 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) DB29_00107 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase DB29_00108 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) DB29_00109 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) DB29_00111 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) DB29_00112 ENOG4105F6E Acyl-transferase DB29_00113 ENOG4105CAT Cytidine monophosphate kinase DB29_00114 ENOG4105MSI germination protein ypeb DB29_00115 ENOG4105F0V Cell wall hydrolase DB29_00118 ENOG4105C28 cystathionine DB29_00120 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) DB29_00121 ENOG4105HDK L-asparaginase DB29_00122 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase DB29_00125 ENOG4105BZU Histidine kinase DB29_00126 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DB29_00127 ENOG4108S6Z Negative regulator of genetic competence DB29_00128 ENOG4108XDN Transcriptional regulator DB29_00129 ENOG4107RGJ metallophosphoesterase DB29_00132 ENOG4105W2C Glycosyl transferase DB29_00133 ENOG4105BZF Glycosyl transferase (Group 1 DB29_00136 ENOG41067QW Transcriptional regulator DB29_00139 ENOG4105I7S Abortive infection protein DB29_00140 ENOG4105C9U ATP-dependent DNA helicase RecQ DB29_00141 ENOG4105T7X DB29_00144 ENOG4108JQ1 Dehydrogenase DB29_00146 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase DB29_00148 ENOG4107TS3 membrane protein, TerC DB29_00151 ENOG4105E0A ABC, transporter DB29_00152 ENOG4105EHG Permease protein DB29_00154 ENOG4105BZU Histidine kinase DB29_00155 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DB29_00156 ENOG4105CRE cytochrome C DB29_00157 ENOG4107TWT Cytochrome c biogenesis protein DB29_00158 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DB29_00159 ENOG4105FE9 pseudouridine synthase DB29_00161 ENOG4108JIC nucleoside recognition domain protein DB29_00162 ENOG4105DZ1 carboxypeptidase DB29_00164 ENOG4105CZ3 stage V sporulation protein ad DB29_00165 ENOG41090VF Stage v sporulation protein ac DB29_00167 ENOG4105H67 Protein of unknown function (DUF421) DB29_00171 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DB29_00172 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DB29_00173 ENOG4105C26 Dehydrogenase DB29_00175 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) DB29_00176 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) DB29_00178 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) DB29_00179 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) DB29_00180 ENOG4108R6K riboflavin synthase, subunit alpha DB29_00183 ENOG4108IPT Naphthoate synthase DB29_00185 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DB29_00186 ENOG4105CR4 methylisocitrate lyase DB29_00187 ENOG4105DXD 2-methylcitrate dehydratase DB29_00192 ENOG4107ZE5 PPIases accelerate the folding of proteins DB29_00194 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DB29_00196 ENOG4105G6R Stage v sporulation protein ae DB29_00198 ENOG4105CZ3 stage V sporulation protein ad DB29_00199 ENOG41090VF Stage v sporulation protein ac DB29_00200 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DB29_00201 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) DB29_00202 ENOG41082AN stage II sporulation protein DB29_00203 ENOG4105DZ1 carboxypeptidase DB29_00204 ENOG4108ZJ4 polysaccharide deacetylase DB29_00205 ENOG4107K5X Membrane-bound metal-dependent hydrolase DB29_00210 ENOG4108ZHJ Organic hydroperoxide resistance protein DB29_00212 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) DB29_00213 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DB29_00215 ENOG4105I3K Ferric uptake regulator, Fur family DB29_00216 ENOG4105MZ9 stage II sporulation protein m DB29_00217 ENOG4108YZ4 nudix hydrolase DB29_00219 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DB29_00220 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DB29_00221 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate DB29_00222 ENOG4108U5N UPF0316 protein DB29_00223 ENOG4105C5Y PTS System DB29_00225 ENOG4107HG4 Transcriptional regulator DB29_00229 ENOG4105CAQ asparagine synthetase DB29_00230 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) DB29_00231 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) DB29_00232 ENOG4105II7 pyrroline-5-carboxylate reductase DB29_00234 ENOG4105CFH Aspartokinase DB29_00237 ENOG4105V75 Transcriptional regulator DB29_00238 ENOG4105PXI polysaccharide deacetylase DB29_00245 ENOG4105XVJ Protein of unknown function (DUF327) DB29_00247 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DB29_00248 ENOG4108ZVT methylmalonyl-coA epimerase DB29_00249 ENOG4108VZI ErfK ybiS ycfS ynhG family protein DB29_00250 ENOG4108QEG Membrane DB29_00251 ENOG4105BZU Histidine kinase DB29_00253 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) DB29_00254 ENOG4105E0X reductase DB29_00255 ENOG4105C9Q fumarate hydratase class II DB29_00261 ENOG41082BV acetyltransferase DB29_00264 ENOG4105DWF phosphomethylpyrimidine kinase DB29_00265 ENOG41080HI glycine oxidase DB29_00266 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) DB29_00268 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) DB29_00269 ENOG4108IJ0 Aspartate ammonia-lyase DB29_00270 ENOG4105DKQ ROK family DB29_00275 ENOG4107ZXI Rhomboid family DB29_00277 ENOG4105DFD Na H antiporter DB29_00278 ENOG4105D06 uba thif-type nad fad binding protein DB29_00280 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase DB29_00281 ENOG4105WDJ 50S ribosomal protein L33 DB29_00286 ENOG4107RF6 penicillin-binding protein DB29_00288 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DB29_00289 ENOG4108UTW Plays a role in the regulation of phosphate uptake DB29_00292 ENOG4105PTM secreted protein DB29_00293 ENOG4107RCC Major Facilitator Superfamily DB29_00295 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) DB29_00296 ENOG41063Y9 DB29_00297 ENOG4108U5J '-nucleotidase DB29_00299 ENOG4105N80 Ferric uptake regulator, Fur family DB29_00301 ENOG4105FDK ABC transporter DB29_00303 ENOG4105BZU Histidine kinase DB29_00305 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) DB29_00308 ENOG4108VJ1 Transcriptional regulator (CarD family DB29_00309 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) DB29_00310 ENOG4105EGD dinuclear metal center protein, YbgI family DB29_00313 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DB29_00314 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) DB29_00315 ENOG4108UPT UPF0178 protein DB29_00317 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) DB29_00319 ENOG4105C38 Glycyl-tRNA synthetase beta subunit DB29_00320 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit DB29_00322 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) DB29_00324 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) DB29_00325 ENOG4105KG3 cytidine deaminase DB29_00326 ENOG4107YR5 Diacylglycerol kinase DB29_00327 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) DB29_00328 ENOG4105CTJ Metal Dependent Phosphohydrolase DB29_00329 ENOG4105C9A Phoh family DB29_00331 ENOG41068P3 sporulation protein YqfC DB29_00334 ENOG4105F7J membrane-bound serine protease DB29_00335 ENOG4105KTH gatB Yqey DB29_00336 ENOG4105VCC 30S ribosomal protein S21 DB29_00339 ENOG4105CPC Aldo Keto reductase DB29_00340 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) DB29_00342 ENOG4105CK2 sodium dicarboxylate symporter DB29_00343 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DB29_00344 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DB29_00345 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) DB29_00346 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) DB29_00347 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) DB29_00348 ENOG4105CFG Acts as a chaperone (By similarity) DB29_00349 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ DB29_00350 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) DB29_00351 ENOG4105CSA Coproporphyrinogen iii oxidase DB29_00352 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) DB29_00354 ENOG4108ZRV stage ii sporulation protein p DB29_00355 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) DB29_00356 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) DB29_00357 ENOG4105TQK DNA polymerase iii, delta' subunit DB29_00359 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 DB29_00360 ENOG4108UK2 deaminase DB29_00361 ENOG4105KQC Competence protein DB29_00363 ENOG4105DXX methyltransferase DB29_00364 ENOG4105QNR S1 RNA binding domain protein DB29_00365 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) DB29_00366 ENOG4108WF2 Metal Dependent Phosphohydrolase DB29_00367 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) DB29_00368 ENOG410812S Rna-binding protein DB29_00369 ENOG4105E2X shikimate dehydrogenase DB29_00370 ENOG4105CQW ribosome biogenesis GTPase YqeH DB29_00371 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase DB29_00373 ENOG4105D65 subunit l DB29_00374 ENOG4105GND monovalent cation H antiporter subunit B DB29_00375 ENOG4105MKQ Monovalent cation H antiporter subunit C DB29_00376 ENOG4108JPZ Monovalent cation H antiporter subunit D DB29_00377 ENOG4105SC1 monovalent cation H antiporter subunit E DB29_00378 ENOG4105W4C monovalent cation H antiporter subunit F DB29_00379 ENOG4105KJM monovalent cation h antiporter subunit g DB29_00380 ENOG4105K70 DNA-binding protein DB29_00383 ENOG4105C94 Transporter DB29_00385 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) DB29_00386 ENOG4108IFG nitrite reductase, (NAD(P)H) DB29_00387 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit DB29_00388 ENOG4108IFG nitrite reductase, (NAD(P)H) DB29_00389 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DB29_00390 ENOG4108RS6 transposase DB29_00394 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DB29_00398 ENOG4105DF9 Lipoate-protein, ligase DB29_00401 ENOG4107T9C Alpha amylase catalytic region DB29_00405 ENOG4107Z3H Transcriptional regulator, TetR family DB29_00406 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DB29_00407 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DB29_00409 ENOG4108JQ7 (ABC) transporter DB29_00410 ENOG4105DEF Extracellular solute-binding protein, family 5 DB29_00413 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) DB29_00414 ENOG4105FDF Could be involved in DNA repair (By similarity) DB29_00415 ENOG4105DQE DNA ligase DB29_00417 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) DB29_00418 ENOG4105DBI uridine monophosphokinase DB29_00419 ENOG4108VQJ O-methyltransferase DB29_00420 ENOG4105HHA aminodeoxychorismate lyase DB29_00422 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) DB29_00423 ENOG4105VBH UPF0297 protein DB29_00424 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DB29_00426 ENOG4105C02 permease DB29_00428 ENOG41060CR DB29_00430 ENOG4105C7H Helicase, RecD TraA family DB29_00432 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) DB29_00433 ENOG4105C3J Cysteine desulfurase DB29_00435 ENOG4105D1H recombination factor protein RarA DB29_00436 ENOG4108VCI transcription factor, rsfa family DB29_00437 ENOG4105CUZ uba thif-type nad fad binding protein DB29_00440 ENOG4105D6E homoserine dehydrogenase DB29_00441 ENOG4105C9M aspartyl-trna synthetase DB29_00442 ENOG4105CUT histidyl-tRNA synthetase DB29_00444 ENOG4107QK9 Beta-lactamase DB29_00445 ENOG4105CK5 oxidoreductase DB29_00448 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) DB29_00449 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DB29_00450 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) DB29_00451 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) DB29_00452 ENOG41067VP Protein of unknown function (DUF1049) DB29_00453 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DB29_00454 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DB29_00456 ENOG4105CKP Polysaccharide Biosynthesis Protein DB29_00459 ENOG4105NAP DB29_00460 ENOG4105VIE preprotein translocase, subunit YajC DB29_00461 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) DB29_00462 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) DB29_00463 ENOG41061AI Protein of unknown function (DUF2905) DB29_00464 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) DB29_00465 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) DB29_00469 ENOG4106678 morphogenetic protein associated with SpoVID DB29_00470 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) DB29_00471 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase DB29_00476 ENOG4105CQC Prephenate dehydratase DB29_00477 ENOG41090I5 UPF0735 ACT domain-containing protein DB29_00478 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control DB29_00482 ENOG4105C1Q protoporphyrinogen oxidase DB29_00483 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) DB29_00484 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) DB29_00485 ENOG4105BZ4 penicillin-binding protein DB29_00486 ENOG4107QIV Cytochrome c biogenesis protein DB29_00490 ENOG4105K59 histidine triad (HIT) protein DB29_00491 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) DB29_00498 ENOG41085KW ppic-type peptidyL-prolyl cis-trans isomerase DB29_00500 ENOG4105EQI Metal Dependent Phosphohydrolase DB29_00501 ENOG4105F3H Histidine kinase DB29_00507 ENOG4106MP8 UPF0754 membrane protein DB29_00515 ENOG4107QX3 carboxylase DB29_00516 ENOG4105E39 Enoyl-CoA hydratase DB29_00517 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit DB29_00518 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DB29_00519 ENOG4105C1G acyl-Coa dehydrogenase DB29_00520 ENOG4108V0P LemA family DB29_00522 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DB29_00523 ENOG4105BZ1 (ABC) transporter DB29_00524 ENOG4105BZ1 (ABC) transporter DB29_00525 ENOG4105ED1 spovr family DB29_00527 ENOG4105C6V Glycerol-3-phosphate dehydrogenase DB29_00528 ENOG4105PW4 Sugar fermentation stimulation protein homolog DB29_00529 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase DB29_00532 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DB29_00533 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase DB29_00537 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) DB29_00538 ENOG4105CE4 GlcNAc 6-P deacetylase DB29_00539 ENOG4105FDP GntR family transcriptional regulator DB29_00540 ENOG4106IQC argininosuccinate lyase DB29_00541 ENOG4105FDP GntR family transcriptional regulator DB29_00543 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DB29_00550 ENOG4105C0R drug resistance transporter emrb qaca subfamily DB29_00554 ENOG4106AKX UPF0229 protein DB29_00555 ENOG4105E0A ABC, transporter DB29_00557 ENOG4105CYN Serine protein kinase DB29_00558 ENOG4105BZ4 penicillin-binding protein DB29_00562 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) DB29_00566 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DB29_00567 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) DB29_00569 ENOG4108WPJ Ferritin-like domain DB29_00570 ENOG4105DER m42 family DB29_00572 ENOG4105CZV ABC transporter DB29_00573 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DB29_00575 ENOG4105CJ1 ABC, transporter DB29_00577 ENOG4106HBX Transcriptional Regulator AraC Family DB29_00579 ENOG4107QK4 glycoside hydrolase, family 3 domain protein DB29_00580 ENOG4105C5Y PTS System DB29_00582 ENOG4105C26 Dehydrogenase DB29_00584 ENOG4105D22 carbon starvation protein DB29_00586 ENOG4105C8P )-transporter DB29_00587 ENOG41060AI SEC-C motif DB29_00589 ENOG4105CGH 5'-nucleotidase DB29_00591 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) DB29_00595 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DB29_00598 ENOG4105X1N Glycosyl transferase family 8 DB29_00601 ENOG4105CJ1 ABC, transporter DB29_00602 ENOG4105WH1 Two component transcriptional regulator luxr family DB29_00603 ENOG4105BZU Histidine kinase DB29_00608 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) DB29_00609 ENOG4105KVH Transcriptional regulator DB29_00613 ENOG4105E5G Alpha beta hydrolase fold DB29_00628 ENOG41069H0 dihydroorotase EC 3.5.2.3 DB29_00633 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) DB29_00639 ENOG4105FQP Beta-lactamase DB29_00640 ENOG4107TXC Transcriptional regulator DB29_00643 ENOG4105C0R drug resistance transporter emrb qaca subfamily DB29_00644 ENOG41062ES Transcriptional regulator DB29_00646 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase DB29_00648 ENOG4105CIR epoxide hydrolase DB29_00650 ENOG4108INS Transcriptional regulator DB29_00652 ENOG4107SCK Monooxygenase DB29_00653 ENOG4108RWP Major Facilitator Superfamily protein DB29_00654 ENOG4105WAB arsR family transcriptional regulator DB29_00659 ENOG4105TUA UPF0295 protein DB29_00660 ENOG4105G5W regulator Fur family DB29_00662 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase DB29_00663 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DB29_00664 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase DB29_00665 ENOG4107NBY Membrane DB29_00666 ENOG4105BZ1 (ABC) transporter DB29_00669 ENOG4105CAN Short-chain dehydrogenase reductase Sdr DB29_00672 ENOG4105CHR reductase DB29_00674 ENOG41067AE Membrane-bound metal-dependent hydrolase DB29_00678 ENOG410902V Modulates RecA activity (By similarity) DB29_00679 ENOG4105ECP epimerase DB29_00681 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DB29_00682 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DB29_00686 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) DB29_00689 ENOG4105C37 (CBS) domain DB29_00690 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DB29_00699 ENOG4105DPN Oligoendopeptidase f DB29_00701 ENOG4105CH6 catalase DB29_00703 ENOG4105C26 Dehydrogenase DB29_00704 ENOG4108B1Q Ribonuclease DB29_00707 ENOG4105KRN Transcriptional regulator, abrb family DB29_00709 ENOG4105C8J )-transporter DB29_00712 ENOG4105DM4 PTS System DB29_00713 ENOG4105DE4 1-phosphofructokinase DB29_00714 ENOG4105E98 transcriptional regulator DeoR family DB29_00715 ENOG4105C5H ABC transporter DB29_00717 ENOG4108V06 Glutathione peroxidase DB29_00718 ENOG4107414 GntR family transcriptional regulator DB29_00719 ENOG4105CG3 alpha amylase, catalytic region DB29_00720 ENOG4105C5Y PTS System DB29_00721 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DB29_00722 ENOG4105F32 YngK protein DB29_00725 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator DB29_00726 ENOG4105C6V Glycerol-3-phosphate dehydrogenase DB29_00727 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) DB29_00729 ENOG4105BZ1 (ABC) transporter DB29_00730 ENOG4105BZ1 (ABC) transporter DB29_00731 ENOG4105EEM helicase DB29_00734 ENOG4105D5T phosphonate abc transporter DB29_00737 ENOG4105II7 pyrroline-5-carboxylate reductase DB29_00742 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DB29_00743 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DB29_00744 ENOG4105DEF Extracellular solute-binding protein, family 5 DB29_00745 ENOG4108JQ7 (ABC) transporter DB29_00746 ENOG4105C3U ABC transporter DB29_00750 ENOG4105CUC YeeE YedE family protein DB29_00752 ENOG4105C7J ABC transporter, permease DB29_00753 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DB29_00756 ENOG4105ECW sulfate abc transporter DB29_00757 ENOG4108I5D sulfate abc transporter DB29_00758 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein DB29_00760 ENOG4108Z66 YbaK ebsC protein DB29_00761 ENOG4105BZU Histidine kinase DB29_00762 ENOG4105CQB FAD linked oxidase domain protein DB29_00763 ENOG4105C09 Bile acid DB29_00764 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase DB29_00765 ENOG4105DUM transcriptional regulator, lysR family DB29_00766 ENOG4105DEF Extracellular solute-binding protein, family 5 DB29_00768 ENOG4108IMY Transcriptional regulator DB29_00769 ENOG4105KNA -acetyltransferase DB29_00771 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component DB29_00772 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component DB29_00776 ENOG4105DA5 (ABC) transporter DB29_00783 ENOG4108ZUB Lysine exporter protein (Lyse ygga) DB29_00784 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DB29_00786 ENOG4105KIR Thiol-disulfide oxidoreductase dcc DB29_00805 ENOG4105WEF catalase DB29_00812 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) DB29_00814 ENOG4105CYW agmatinase DB29_00816 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DB29_00818 ENOG4105DZ1 carboxypeptidase DB29_00819 ENOG4108ZHR arsR family transcriptional regulator DB29_00820 ENOG4108SQ9 flavin reductase domain protein, FMN-binding DB29_00824 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DB29_00828 ENOG4108M1A Chitin-binding protein DB29_00829 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase DB29_00831 ENOG4105DZY Pts system, glucitol sorbitol-specific DB29_00832 ENOG410787A Pts system, glucitol sorbitol-specific DB29_00834 ENOG4105DKT Transcriptional regulator DB29_00836 ENOG4107QZW Altronate oxidoreductase DB29_00837 ENOG4105CTX dehydratase DB29_00838 ENOG4105DDC Oxidoreductase domain protein DB29_00839 ENOG4105MU9 integral membrane protein DB29_00841 ENOG4105F5H Glycosyl Hydrolase Family 88 DB29_00844 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component DB29_00848 ENOG41075H3 AraC family transcriptional regulator DB29_00849 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) DB29_00850 ENOG4105E08 Glycoside hydrolase, family 9 DB29_00856 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component DB29_00858 ENOG4105EQD regulatoR DB29_00859 ENOG4105C2F Histidine kinase DB29_00860 ENOG4105CJQ hydrolase, family 31 DB29_00863 ENOG4105E2R ROK family DB29_00864 ENOG4105CNG UPF0061 protein DB29_00865 ENOG4105CTX dehydratase DB29_00867 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DB29_00870 ENOG4108ERU trap dicarboxylate transporter subunit DctP DB29_00871 ENOG4105E7U AraC family transcriptional regulator DB29_00872 ENOG4105ERH Fumarylacetoacetate hydrolase DB29_00873 ENOG4105EC3 peptidase S51, dipeptidase E DB29_00876 ENOG4105CKI cobalamin synthesis protein DB29_00877 ENOG4108MEK Metal-binding protein YodA DB29_00878 ENOG4105DSE periplasmic solute binding protein DB29_00879 ENOG4105FDK ABC transporter DB29_00881 ENOG4105C26 Dehydrogenase DB29_00882 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DB29_00884 ENOG4107HP6 Transcriptional regulator DB29_00886 ENOG4105C01 Dihydroxy-acid dehydratase DB29_00889 ENOG4107EXU Short-chain dehydrogenase reductase Sdr DB29_00896 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DB29_00899 ENOG4105CBD Diacylglycerol kinase DB29_00900 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) DB29_00901 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DB29_00902 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) DB29_00907 ENOG4105UIB (ABC) transporter DB29_00908 ENOG4108JQ9 ABC transporter DB29_00909 ENOG4105DIH basic membrane DB29_00911 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) DB29_00912 ENOG4105C4R Atp-dependent dna helicase DB29_00913 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) DB29_00915 ENOG4105E0A ABC, transporter DB29_00916 ENOG4105EHG Permease protein DB29_00917 ENOG4105DQ5 transport system permease protein DB29_00921 ENOG4105CUJ penicillin amidase DB29_00922 ENOG4105CPN adenine deaminase DB29_00923 ENOG4105KGF protein, YerC YecD DB29_00926 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs DB29_00930 ENOG4107HG4 Transcriptional regulator DB29_00940 ENOG4105CJ1 ABC, transporter DB29_00941 ENOG4105WH1 Two component transcriptional regulator luxr family DB29_00942 ENOG4105BZU Histidine kinase DB29_00945 ENOG4105CHR reductase DB29_00947 ENOG4105CPQ Dehydrogenase DB29_00948 ENOG4105CHR reductase DB29_00949 ENOG4105ETE Transcriptional regulator (LacI family DB29_00952 ENOG4105C12 Phosphoribosylglycinamide synthetase DB29_00953 ENOG4105DC1 bifunctional purine biosynthesis protein purh DB29_00954 ENOG4108V3E phosphoribosylglycinamide formyltransferase DB29_00955 ENOG4105CXB phosphoribosylaminoimidazole synthetase DB29_00956 ENOG4105CXB phosphoribosylaminoimidazole synthetase DB29_00958 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii DB29_00960 ENOG4105VR9 phosphoribosylformylglycinamidine synthase DB29_00961 ENOG4105C8V SAICAR synthetase DB29_00962 ENOG4105C83 adenylosuccinate lyase DB29_00963 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit DB29_00964 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) DB29_00975 ENOG4108MRH transcriptional regulatory protein DB29_00976 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism DB29_00977 ENOG4107SUZ Sodium/hydrogen exchanger family DB29_00978 ENOG4105BZ1 (ABC) transporter DB29_00979 ENOG4105BZ1 (ABC) transporter DB29_00987 ENOG41065KQ synthase DB29_00988 ENOG4107TXC Transcriptional regulator DB29_00990 ENOG4105D2H Uronic isomerase DB29_00991 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) DB29_00992 ENOG4105CHR reductase DB29_00993 ENOG4105E98 transcriptional regulator DeoR family DB29_00994 ENOG4105FGV Chromate DB29_00995 ENOG4105CAH Chromate DB29_00996 ENOG4105E63 Pfam:DUF178 DB29_00997 ENOG4108UIH futalosine nucleosidase DB29_01004 ENOG4105TRT Transcriptional regulator DB29_01005 ENOG4105C26 Dehydrogenase DB29_01006 ENOG4108JB8 alcohol dehydrogenase DB29_01007 ENOG4105JXH GntR family transcriptional regulator DB29_01008 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) DB29_01009 ENOG4107QR9 Iron-sulfur cluster binding protein DB29_01010 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DB29_01011 ENOG4105DAA L-lactate DB29_01014 ENOG4105CFC Transporter DB29_01015 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) DB29_01016 ENOG4105GTG Isochorismatase DB29_01018 ENOG4105VZ8 Transcriptional regulator DB29_01019 ENOG4105CGH 5'-nucleotidase DB29_01021 ENOG4105C26 Dehydrogenase DB29_01022 ENOG4108JUB Transcriptional regulator DB29_01028 ENOG4105C7N Xanthine uracil vitamin C permease DB29_01034 ENOG4105VDH Dihydroxyacetone kinase DB29_01035 ENOG4108UTZ Dihydroxyacetone kinase DB29_01036 ENOG4105CMT Dihydroxyacetone kinase DB29_01038 ENOG4105CV1 Transketolase (EC 2.2.1.1) DB29_01041 ENOG4108XBJ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) DB29_01042 ENOG4105DBI uridine monophosphokinase DB29_01043 ENOG4105VUF Transcriptional regulator DB29_01044 ENOG4105EMU Dehydrogenase DB29_01045 ENOG4105DZR Type I site-specific deoxyribonuclease DB29_01047 ENOG4105CVR type I restriction-modification system DB29_01048 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) DB29_01049 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) DB29_01059 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DB29_01062 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DB29_01064 ENOG41088CQ domain protein DB29_01067 ENOG4107RVG penicillin-binding protein DB29_01068 ENOG4107Y03 Nitroreductase DB29_01079 ENOG4105C6K Malic enzyme DB29_01081 ENOG4108MRH transcriptional regulatory protein DB29_01083 ENOG410682Q Phage transcriptional regulator, ArpU DB29_01086 ENOG4105E5Q amino acid AbC transporter DB29_01091 ENOG4105CKK Glycosyl transferase, family 2 DB29_01093 ENOG4105EJV Membrane DB29_01098 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DB29_01100 ENOG4108IEG Formate dehydrogenase Alpha subunit DB29_01101 ENOG4108QTI )-transporter DB29_01102 ENOG41067WU Molybdopterin converting factor (Subunit 1) DB29_01103 ENOG4108ZAF Molybdopterin DB29_01104 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein DB29_01105 ENOG4105CVM Molybdenum cofactor synthesis domain protein DB29_01106 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DB29_01107 ENOG4105EPU Molybdenum cofactor synthesis domain protein DB29_01108 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) DB29_01111 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) DB29_01113 ENOG4108SU4 UPF0309 protein DB29_01114 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC DB29_01118 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) DB29_01119 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) DB29_01120 ENOG4108TYN CAAX amino terminal protease family protein DB29_01122 ENOG4107SCQ Iron-containing alcohol dehydrogenase DB29_01123 ENOG4105D01 (LipO)protein DB29_01124 ENOG4108UMI ABC transporter, permease DB29_01125 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DB29_01127 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DB29_01128 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) DB29_01129 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) DB29_01130 ENOG4105C5H ABC transporter DB29_01132 ENOG410801F ribosomal-protein-alanine acetyltransferase DB29_01133 ENOG41072GX Peptidase M22 Glycoprotease DB29_01134 ENOG4105K8N protein family UPF0079, ATPase DB29_01135 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) DB29_01138 ENOG4105C28 cystathionine DB29_01140 ENOG4107P6T Protein CrcB homolog DB29_01141 ENOG4105KT7 mgtC SapB transporter DB29_01148 ENOG41075D4 Aminoglycoside 6-adenylyltransferase DB29_01149 ENOG4105DM4 PTS System DB29_01151 ENOG4105EMD TRANSCRIPTIONal DB29_01156 ENOG4108UMN azlc family DB29_01157 ENOG4105KMT branched-chain amino acid DB29_01158 ENOG4108ZMX Domain of unknown function (DU1801) DB29_01161 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DB29_01162 ENOG4105E3J oxidoreductase DB29_01166 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DB29_01168 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DB29_01169 ENOG4105F0F Oxalate decarboxylase DB29_01171 ENOG4107R5R arsenical pump membrane protein DB29_01172 ENOG41082YX Transcriptional regulator, arsr family DB29_01173 ENOG4108VJ1 Transcriptional regulator (CarD family DB29_01174 ENOG4105VEQ Cold shock protein DB29_01175 ENOG4105EP9 oxidoreductase DB29_01177 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein DB29_01179 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DB29_01180 ENOG4105EYF MMPL domain protein DB29_01182 ENOG410906U SprT-like DB29_01187 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) DB29_01188 ENOG4105WN5 stage II sporulation protein DB29_01189 ENOG4107SGM protein serine threonine phosphatase DB29_01190 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase DB29_01191 ENOG4105FUA antagonist DB29_01192 ENOG4107MMM Anti-sigma-factor antagonist DB29_01193 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) DB29_01195 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DB29_01196 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein DB29_01200 ENOG4105E0M Sulfatase DB29_01202 ENOG4108VXD carboxy-peptidase DB29_01205 ENOG4105T0Z Conserved Protein DB29_01208 ENOG4107QP6 Xylose isomerase domain protein TIM barrel DB29_01211 ENOG4105KJM monovalent cation h antiporter subunit g DB29_01213 ENOG4105IMY monovalent cation H antiporter subunit E DB29_01214 ENOG4108JPZ Monovalent cation H antiporter subunit D DB29_01215 ENOG4108ZE9 Monovalent cation H antiporter subunit C DB29_01216 ENOG4108PMQ Na H antiporter MnhB subunit-related protein DB29_01217 ENOG4105D65 subunit l DB29_01220 ENOG4105KVH Transcriptional regulator DB29_01221 ENOG4108JQ7 (ABC) transporter DB29_01222 ENOG4107SN7 NLP P60 protein DB29_01223 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DB29_01225 ENOG4105C3U ABC transporter DB29_01226 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DB29_01227 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DB29_01228 ENOG4108ME1 Peptidase M55 D-aminopeptidase DB29_01231 ENOG4105DRP amino acid AbC transporter DB29_01232 ENOG4105EAD ABC transporter DB29_01233 ENOG4105CT1 (ABC) transporter DB29_01235 ENOG4105FR1 rard protein DB29_01236 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) DB29_01237 ENOG4105DCF alanine dehydrogenase DB29_01238 ENOG4108K8K Transcriptional regulator DB29_01239 ENOG4105KHC sulfurtransferase DB29_01240 ENOG4105CUB amino acid DB29_01243 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin DB29_01245 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DB29_01246 ENOG4105D74 hydrolase DB29_01247 ENOG4107TS3 membrane protein, TerC DB29_01249 ENOG4105ETU transcriptional activator (TenA DB29_01250 ENOG4108R3E Dna-3-methyladenine glycosylase i DB29_01253 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin DB29_01254 ENOG4108W76 histidinol phosphate phosphatase hisj family DB29_01255 ENOG4105CIS alcohol dehydrogenase DB29_01256 ENOG4107ZE5 PPIases accelerate the folding of proteins DB29_01258 ENOG4108R1P DB29_01259 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR DB29_01260 ENOG4105BZW Glycerate kinase DB29_01265 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DB29_01266 ENOG4108W0I acetyltransferase DB29_01267 ENOG4105XT2 Transcriptional regulator DB29_01270 ENOG41090MY MarR family Transcriptional regulator DB29_01272 ENOG4105CJW magnesium transporter DB29_01273 ENOG4108S01 response regulator DB29_01274 ENOG4108ZGX Histidine kinase DB29_01275 ENOG4105ECK Fatty Acid Desaturase DB29_01278 ENOG4107T5V SNARE associated Golgi DB29_01279 ENOG4106DF4 Sigma-70, region 4 DB29_01281 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component DB29_01283 ENOG4105EQD regulatoR DB29_01284 ENOG4105C2F Histidine kinase DB29_01288 ENOG4105WH1 Two component transcriptional regulator luxr family DB29_01293 ENOG4108IUE nitrate reductase beta subunit DB29_01296 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DB29_01298 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) DB29_01299 ENOG4105QEK Transcriptional regulator DB29_01332 ENOG4105EC2 ftsk spoIIIe DB29_01336 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component DB29_01337 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component DB29_01339 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) DB29_01340 ENOG4105DKW ABC transporter DB29_01342 ENOG4105CHR reductase DB29_01343 ENOG4105F7F Chaperone DB29_01344 ENOG4105QFC Hsc56 co-chaperone of HscC DB29_01345 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) DB29_01346 ENOG4108626 Racemase DB29_01347 ENOG4106PKC pyridoxal phosphate binding DB29_01348 ENOG41080QX K07048 phosphotriesterase-related protein DB29_01349 ENOG4106M0N transport system permease protein DB29_01350 ENOG4105MUZ Protein of unknown function DUF2620 DB29_01354 ENOG4105ETU transcriptional activator (TenA DB29_01356 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism DB29_01357 ENOG4108V9W transcriptional regulatory protein DB29_01358 ENOG4105D4T Citrate transporter DB29_01363 ENOG4105C6Z Gluconate DB29_01364 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) DB29_01365 ENOG4105G63 Type III effector Hrp-dependent DB29_01366 ENOG4105MVE transcriptional regulator DB29_01367 ENOG4105E1K spore germination protein DB29_01368 ENOG4108Q5U germination protein, ger(x)c family DB29_01373 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) DB29_01374 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) DB29_01375 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs DB29_01377 ENOG4105DCM major facilitator superfamily DB29_01383 ENOG4108X79 transcriptional regulator DB29_01385 ENOG4105F8D glycoside hydrolase family 4 DB29_01386 ENOG4105CK1 PTS System DB29_01387 ENOG4105VCP PTS System DB29_01388 ENOG4105VZJ PTS System DB29_01389 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) DB29_01392 ENOG4108RWP Major Facilitator Superfamily protein DB29_01395 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase DB29_01396 ENOG4105DMW Dehydrogenase reductase DB29_01397 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) DB29_01398 ENOG4105CPQ Dehydrogenase DB29_01399 ENOG4107EFR Flavocytochrome c DB29_01400 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DB29_01401 ENOG4108KAM Transcriptional regulator DB29_01406 ENOG4105CZE histidine utilization repressor DB29_01407 ENOG4105DVE abc transporter atp-binding protein DB29_01409 ENOG4107QHM Sulfite reductase DB29_01410 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DB29_01411 ENOG4108Z73 Siroheme synthase DB29_01412 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein DB29_01413 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DB29_01414 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) DB29_01416 ENOG4107RIQ Sulfate adenylate transferase DB29_01417 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) DB29_01418 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DB29_01419 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter DB29_01420 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit DB29_01423 ENOG4107XBN GntR Family Transcriptional Regulator DB29_01426 ENOG4105E2Y ABC, transporter DB29_01427 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DB29_01429 ENOG4105GVF (ABC) transporter DB29_01430 ENOG4108UZX fmn reductase DB29_01433 ENOG4108RPX mosc domain containing protein DB29_01438 ENOG4105CEY Amp-dependent synthetase and ligase DB29_01443 ENOG4105VSH 4-oxalocrotonate tautomerase DB29_01444 ENOG4105CBP Major Facilitator DB29_01446 ENOG4105HBA AroM protein DB29_01451 ENOG4105G9B Transcriptional regulator DB29_01454 ENOG4105E2R ROK family DB29_01455 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) DB29_01456 ENOG4105CMG Carbohydrate kinase DB29_01457 ENOG4105C93 Xylose Isomerase DB29_01458 ENOG4107HP6 Transcriptional regulator DB29_01459 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) DB29_01461 ENOG4108JQ7 (ABC) transporter DB29_01463 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DB29_01465 ENOG4105DEF Extracellular solute-binding protein, family 5 DB29_01466 ENOG4105CI2 imidazolone-5-propionate hydrolase DB29_01467 ENOG4105CI2 imidazolone-5-propionate hydrolase DB29_01472 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component DB29_01475 ENOG4105DSG hydrolase family 43 DB29_01476 ENOG4105FTV AraC Family Transcriptional Regulator DB29_01478 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DB29_01479 ENOG4108UMI ABC transporter, permease DB29_01481 ENOG4105CH2 amidohydrolase DB29_01483 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DB29_01484 ENOG4105C6Z Gluconate DB29_01485 ENOG4106KNT transcriptional regulator DB29_01488 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase DB29_01489 ENOG4105JXH GntR family transcriptional regulator DB29_01490 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F DB29_01492 ENOG4108IA2 Sodium pantothenate symporter DB29_01500 ENOG4105FF2 Type I DHQase DB29_01503 ENOG4105CS1 NAD(P)H quinone oxidoreductase DB29_01505 ENOG4107VFR oxidoreductase DB29_01508 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DB29_01509 ENOG4105EB3 Histidine kinase DB29_01514 ENOG4105CXK mandelate racemase muconate lactonizing DB29_01516 ENOG4105D7K pfkb domain protein DB29_01519 ENOG4105XJB lipolytic protein G-D-S-L family DB29_01520 ENOG4105JD4 ATPase yjob DB29_01524 ENOG4107QJZ Glycosyl transferase, family 2 DB29_01526 ENOG4107QQG Dehydrogenase DB29_01529 ENOG4105CPK Glycosyl transferase (Group 1 DB29_01532 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) DB29_01536 ENOG4108R96 Methyltransferase, YaeB family DB29_01538 ENOG41089UC methyltransferase, type 11 DB29_01540 ENOG4105CSA Coproporphyrinogen iii oxidase DB29_01541 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E DB29_01547 ENOG4106849 propeptide, pepSY amd peptidase M4 DB29_01549 ENOG41062D9 Histidine kinase DB29_01550 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DB29_01551 ENOG4108SU4 UPF0309 protein DB29_01552 ENOG4105FDP GntR family transcriptional regulator DB29_01554 ENOG41069ER domain protein DB29_01559 ENOG4105EMD TRANSCRIPTIONal DB29_01560 ENOG4105CS2 ec 3.2.1.21 DB29_01561 ENOG4105VCP PTS System DB29_01562 ENOG4105CK1 PTS System DB29_01563 ENOG4105VZJ PTS System DB29_01564 ENOG4105DDN Pentapeptide repeat-containing protein DB29_01568 ENOG4105DJ2 Major Facilitator Superfamily DB29_01570 ENOG41073TP transcriptional regulator DB29_01571 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase DB29_01572 ENOG4105C26 Dehydrogenase DB29_01576 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) DB29_01578 ENOG4106FGC DB29_01586 ENOG4105C8Q Methyl-accepting chemotaxis DB29_01588 ENOG4105D4T Citrate transporter DB29_01591 ENOG4108JUB Transcriptional regulator DB29_01592 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) DB29_01593 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) DB29_01594 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DB29_01598 ENOG4105DM4 PTS System DB29_01599 ENOG4108YRF PTS System DB29_01600 ENOG4105DM4 PTS System DB29_01601 ENOG4105D2N Aldolase DB29_01602 ENOG4105ETD TRANSCRIPTIONal DB29_01603 ENOG4107QZW Altronate oxidoreductase DB29_01604 ENOG4105CTX dehydratase DB29_01605 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DB29_01607 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit DB29_01609 ENOG4105CPQ Dehydrogenase DB29_01610 ENOG4108DMH HTH_ARAC DB29_01611 ENOG4107YY3 extracellular solute-binding protein family 1 DB29_01612 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component DB29_01617 ENOG410900G Protein of unknown function (DUF421) DB29_01618 ENOG4107RUZ Sss sodium solute transporter superfamily DB29_01619 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) DB29_01621 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) DB29_01622 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) DB29_01623 ENOG4107QK6 Thiamine pyrophosphate DB29_01624 ENOG4105EDK PfkB domain protein DB29_01626 ENOG4105C26 Dehydrogenase DB29_01631 ENOG4105KPY Small multidrug resistance protein DB29_01632 ENOG4105KPY Small multidrug resistance protein DB29_01633 ENOG4105DY9 regulatoR DB29_01641 ENOG4108HWW ABC transporter DB29_01642 ENOG4105C2J ABC transporter DB29_01643 ENOG4105DFW ABC transporter DB29_01645 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) DB29_01646 ENOG4108HMQ sugar kinase DB29_01648 ENOG4108MDK Dehydrogenase DB29_01652 ENOG4105MU9 integral membrane protein DB29_01653 ENOG4105DRS transport system, permease DB29_01654 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component DB29_01657 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component DB29_01658 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component DB29_01660 ENOG4105CX8 fg-gap repeat protein DB29_01663 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DB29_01664 ENOG4105GR3 Histidine kinase DB29_01666 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component DB29_01667 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component DB29_01668 ENOG410769Z extracellular solute-binding protein family 1 DB29_01669 ENOG4105EQD regulatoR DB29_01670 ENOG4105C2F Histidine kinase DB29_01675 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) DB29_01677 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) DB29_01679 ENOG4105DKG l-rhamnose isomerase DB29_01682 ENOG4105CYW agmatinase DB29_01686 ENOG4107ZQV short-chain dehydrogenase reductase DB29_01689 ENOG4105CK5 oxidoreductase DB29_01692 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component DB29_01694 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator DB29_01697 ENOG4105EV4 Multidrug resistance protein mdtH DB29_01698 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DB29_01699 ENOG4105BZ7 extracellular solute-binding protein family 1 DB29_01700 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component DB29_01701 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component DB29_01702 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DB29_01703 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DB29_01704 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DB29_01708 ENOG4105EWI Short-chain dehydrogenase reductase Sdr DB29_01720 ENOG4107F3J Amp-dependent synthetase and ligase DB29_01721 ENOG4105CEY Amp-dependent synthetase and ligase DB29_01722 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DB29_01723 ENOG4105DRS transport system, permease DB29_01724 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component DB29_01728 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) DB29_01729 ENOG4108JPW Aminotransferase DB29_01730 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase DB29_01733 ENOG4105C26 Dehydrogenase DB29_01734 ENOG4105C0A alcohol dehydrogenase DB29_01735 ENOG4105CSV Glutaminase DB29_01736 ENOG4105CY2 Citrate transporter DB29_01738 ENOG4108JUB Transcriptional regulator DB29_01742 ENOG4108ZIE 5 nucleotidase deoxy cytosolic type C DB29_01748 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component DB29_01749 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component DB29_01750 ENOG41066F8 ROK family DB29_01751 ENOG4105CS2 ec 3.2.1.21 DB29_01752 ENOG4105ETE Transcriptional regulator (LacI family DB29_01755 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate DB29_01758 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) DB29_01759 ENOG4107S2N Type III effector Hrp-dependent DB29_01760 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) DB29_01761 ENOG4106KNT transcriptional regulator DB29_01762 ENOG4105BZ1 (ABC) transporter DB29_01763 ENOG4107SWG transcriptional regulator MERR family DB29_01764 ENOG4107KJX Transcriptional regulator DB29_01765 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit DB29_01767 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DB29_01773 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) DB29_01774 ENOG4105C02 permease DB29_01776 ENOG41090A1 ferritin DB29_01778 ENOG4105D9N nucleoside DB29_01779 ENOG4105U6C Alpha beta hydrolase fold protein DB29_01781 ENOG4105C94 Transporter DB29_01788 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DB29_01789 ENOG4107Y9U Membrane DB29_01791 ENOG4105C31 Tryptophanyl-tRNA synthetase DB29_01792 ENOG4108D32 Methyltransferase DB29_01795 ENOG4105H3G oxidoreductase DB29_01803 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) DB29_01809 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) DB29_01811 ENOG4107Y80 Major Facilitator superfamily DB29_01812 ENOG4105XEA Tetr family transcriptional regulator DB29_01815 ENOG4105C19 ABC transporter DB29_01816 ENOG41087PP glycosyltransferase MGT family DB29_01817 ENOG4108IMY Transcriptional regulator DB29_01820 ENOG4106AXJ AraC family transcriptional regulator DB29_01821 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) DB29_01822 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) DB29_01824 ENOG4105C8B TIGR00159 family DB29_01826 ENOG4105EMN RNA polymerase sigma factor DB29_01829 ENOG4105DEF Extracellular solute-binding protein, family 5 DB29_01838 ENOG4108JUB Transcriptional regulator DB29_01839 ENOG4105CMJ mandelate racemase muconate lactonizing DB29_01841 ENOG4107SWG transcriptional regulator MERR family DB29_01844 ENOG4107TXC Transcriptional regulator DB29_01845 ENOG4108D32 Methyltransferase DB29_01849 ENOG4108NMV polysaccharide deacetylase DB29_01857 ENOG4105D1F ATP-binding protein DB29_01859 ENOG4105CID antiterminator DB29_01869 ENOG4108UJD 30S ribosomal protein S9 DB29_01870 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) DB29_01871 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DB29_01872 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) DB29_01875 ENOG4108ZT0 50S ribosomal protein l17 DB29_01876 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DB29_01877 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) DB29_01878 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits DB29_01879 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) DB29_01880 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DB29_01881 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) DB29_01882 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DB29_01883 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) DB29_01884 ENOG4105VPB 50S ribosomal protein L30 DB29_01885 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) DB29_01886 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) DB29_01887 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) DB29_01888 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) DB29_01889 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) DB29_01890 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits DB29_01891 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) DB29_01892 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) DB29_01893 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal DB29_01894 ENOG41082SA 50s ribosomal protein l29 DB29_01895 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) DB29_01896 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) DB29_01897 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) DB29_01898 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) DB29_01899 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity DB29_01900 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) DB29_01901 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) DB29_01902 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) DB29_01903 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) DB29_01904 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) DB29_01905 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) DB29_01906 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) DB29_01907 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) DB29_01908 ENOG4105XPM ribosomal protein DB29_01909 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DB29_01910 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DB29_01911 ENOG4107Y49 methyltransferase DB29_01912 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) DB29_01913 ENOG4108VZM 50s ribosomal protein L10 DB29_01914 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) DB29_01915 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) DB29_01916 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) DB29_01917 ENOG410683Z Preprotein translocase SecE subunit DB29_01918 ENOG4105QIV RNA polymerase DB29_01919 ENOG4105M0M Tetracycline resistance protein DB29_01920 ENOG4105C2N RNA methyltransferase TrmH family group 3 DB29_01922 ENOG4105C8N cysteinyl-tRNA synthetase DB29_01923 ENOG4105D7W serine acetyltransferase DB29_01924 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) DB29_01925 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) DB29_01926 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) DB29_01927 ENOG4105CTP PilT protein domain protein DB29_01928 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) DB29_01929 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) DB29_01931 ENOG41066A3 ATP guanido phosphotransferase DB29_01932 ENOG4108Z0C Uvrb UvrC protein DB29_01935 ENOG4105CRK lysyL-tRNA synthetase DB29_01936 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) DB29_01937 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase DB29_01938 ENOG4105KRF dihydroneopterin aldolase DB29_01939 ENOG4105EEI dihydropteroate synthase DB29_01940 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 DB29_01941 ENOG4105DDQ anthranilate synthase DB29_01942 ENOG4105CRQ synthase (Component I) DB29_01943 ENOG4105C6T cysteine synthase DB29_01944 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) DB29_01946 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) DB29_01947 ENOG4108UGV hypoxanthine phosphoribosyltransferase DB29_01948 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) DB29_01952 ENOG4105D4T Citrate transporter DB29_01953 ENOG41060GV RNA binding s1 domain protein DB29_01956 ENOG4105VYY sporulation protein yabp DB29_01959 ENOG4105WCN acetyltransferase DB29_01960 ENOG4105C5I Dehydrogenase DB29_01961 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 DB29_01962 ENOG41082I2 s4 domain protein DB29_01963 ENOG4108IY2 MazG family DB29_01966 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DB29_01968 ENOG4108M14 stage v sporulation protein t DB29_01969 ENOG4108JA2 transcriptioN-repair coupling factor DB29_01971 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) DB29_01972 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) DB29_01973 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DB29_01974 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) DB29_01976 ENOG4105K4W Could be involved in septation (By similarity) DB29_01977 ENOG4105KME endoribonuclease L-psp DB29_01978 ENOG4105DFT pur operon repressor DB29_01979 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) DB29_01981 ENOG4105W42 Veg protein DB29_01982 ENOG4105XFA sporulation peptidase YabG DB29_01983 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) DB29_01984 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) DB29_01985 ENOG41069ER domain protein DB29_01986 ENOG4105F8V Hydrolase, tatD family DB29_01991 ENOG4105C5H ABC transporter DB29_01993 ENOG4108J20 pectate lyase DB29_01995 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) DB29_01998 ENOG4105KRN Transcriptional regulator, abrb family DB29_01999 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) DB29_02000 ENOG4105VC4 domain protein DB29_02001 ENOG41060K3 Methyltransferase DB29_02002 ENOG41063V3 Involved in initiation control of chromosome replication (By similarity) DB29_02003 ENOG4105MA4 psp1 domain protein DB29_02004 ENOG4105FA2 dna polymerase iii DB29_02005 ENOG4105X0R protein from nitrogen regulatory protein P-II DB29_02006 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) DB29_02007 ENOG4105CXN decarboxylase DB29_02010 ENOG4105C26 Dehydrogenase DB29_02012 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DB29_02018 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) DB29_02019 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) DB29_02020 ENOG4105C6E dna polymerase iii DB29_02023 ENOG4108Z6B deaminase DB29_02024 ENOG4105DEF Extracellular solute-binding protein, family 5 DB29_02025 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DB29_02026 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DB29_02027 ENOG4105C3U ABC transporter DB29_02028 ENOG4108JQ7 (ABC) transporter DB29_02030 ENOG4105E5Q amino acid AbC transporter DB29_02031 ENOG4107R0W ABC transporter DB29_02034 ENOG4105D6E homoserine dehydrogenase DB29_02036 ENOG4105C28 cystathionine DB29_02037 ENOG4105ENR peptidase, M24 DB29_02039 ENOG4105DFD Na H antiporter DB29_02040 ENOG4105D82 Glutamate dehydrogenase DB29_02041 ENOG4105C8Y Acetylornithine aminotransferase DB29_02042 ENOG4108JUB Transcriptional regulator DB29_02043 ENOG4105G9B Transcriptional regulator DB29_02044 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase DB29_02045 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) DB29_02047 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DB29_02051 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DB29_02053 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DB29_02054 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DB29_02056 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) DB29_02057 ENOG410848D S4 domain protein YaaA DB29_02058 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DB29_02059 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) DB29_02060 ENOG4105VG0 50S ribosomal protein l34 DB29_02061 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) DB29_02063 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein DB29_02065 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) DB29_02066 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) DB29_02067 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) DB29_02069 ENOG4107QJE Chromosome Partitioning Protein DB29_02070 ENOG4105FA0 parb-like partition protein DB29_02071 ENOG4105C9B Cysteine desulfurase DB29_02072 ENOG4108ZDA Sporulation protein YyaC DB29_02074 ENOG4105VDK protein, conserved in bacteria DB29_02075 ENOG4105C3G gtp-binding protein DB29_02076 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) DB29_02077 ENOG4108UUM single-stranded DNA-binding protein DB29_02078 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) DB29_02080 ENOG4105BZR domain protein DB29_02081 ENOG4105K9Q Binds to the 23S rRNA (By similarity) DB29_02082 ENOG4105CDU Replicative dna helicase DB29_02083 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis DB29_02084 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DB29_02085 ENOG4105BZU Histidine kinase DB29_02088 ENOG4105Q2H domain protein DB29_02089 ENOG4105C0H protease DB29_02090 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) DB29_02096 ENOG4105CPQ Dehydrogenase DB29_02097 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit DB29_02098 ENOG41069H7 transport system small permease component DB29_02099 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DB29_02100 ENOG4105FB2 class II Aldolase DB29_02102 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DB29_02103 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) DB29_02104 ENOG4105F3R pts system mannose fructose sorbose family iid DB29_02106 ENOG4105KPI PTS system sorbose subfamily IIB component DB29_02108 ENOG4105CJ1 ABC, transporter DB29_02117 ENOG4105C3U ABC transporter DB29_02118 ENOG4108JQ7 (ABC) transporter DB29_02122 ENOG4108HRK Histidine kinase DB29_02123 ENOG4105DY9 regulatoR DB29_02129 ENOG4105JVQ RNA Polymerase DB29_02132 ENOG4105DG4 malate L-lactate dehydrogenase DB29_02133 ENOG4107XBN GntR Family Transcriptional Regulator DB29_02134 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit DB29_02136 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DB29_02137 ENOG4105BZN citrate synthase DB29_02141 ENOG4105JXH GntR family transcriptional regulator DB29_02142 ENOG4105JXH GntR family transcriptional regulator DB29_02143 ENOG4105CQB FAD linked oxidase domain protein DB29_02144 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DB29_02145 ENOG4105D5U fad dependent oxidoreductase DB29_02146 ENOG4105G9B Transcriptional regulator DB29_02147 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin DB29_02148 ENOG4105DZC cytosine deaminase DB29_02150 ENOG4107FKK extracellular solute-binding protein family 1 DB29_02152 ENOG4105EG2 ABC transporter, permease DB29_02153 ENOG4105ETE Transcriptional regulator (LacI family DB29_02154 ENOG4105CRW Short chain fatty acid transporter DB29_02155 ENOG4105D6N CoA-transferase, subunit a DB29_02156 ENOG4108IIH CoA-transferase subunit B DB29_02157 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) DB29_02159 ENOG4105D3A purine nucleoside phosphorylase DeoD-type DB29_02160 ENOG4105CKI cobalamin synthesis protein DB29_02161 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) DB29_02162 ENOG4105C98 muts2 protein DB29_02163 ENOG4108RCR degv family DB29_02172 ENOG4105DJ2 Major Facilitator Superfamily DB29_02175 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DB29_02176 ENOG4105BZU Histidine kinase DB29_02179 ENOG41090A4 Pterin carbinolamine dehydratase DB29_02180 ENOG4105C8J )-transporter DB29_02190 ENOG41081VB Hydrolase DB29_02192 ENOG4108MRH transcriptional regulatory protein DB29_02193 ENOG4105C8P )-transporter DB29_02201 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) DB29_02210 ENOG4105FTQ Dna gyrase DB29_02212 ENOG4105C22 threonyL-tRNA synthetase DB29_02213 ENOG4105RHY Pfam:UPF0157 DB29_02215 ENOG4107TXC Transcriptional regulator DB29_02217 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) DB29_02218 ENOG4108QG2 Membrane DB29_02219 ENOG4107XC4 flavin reductase domain protein, FMN-binding DB29_02220 ENOG4105D4A Cell wall formation (By similarity) DB29_02221 ENOG4105BZ1 (ABC) transporter DB29_02222 ENOG4105CH6 catalase DB29_02225 ENOG4105DAP Nicotinate phosphoribosyltransferase DB29_02226 ENOG4105C8Q Methyl-accepting chemotaxis DB29_02228 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) DB29_02231 ENOG4105DSE periplasmic solute binding protein DB29_02232 ENOG4105DIK (ABC) transporter DB29_02233 ENOG4105CC5 ABC transporter DB29_02234 ENOG4105CC5 ABC transporter DB29_02237 ENOG4105VCH membrane DB29_02238 ENOG4105DR4 Methyltransferase DB29_02239 ENOG4105C9U ATP-dependent DNA helicase RecQ DB29_02240 ENOG4105G6Z alkaline phosphatase DB29_02242 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) DB29_02243 ENOG4105DZ6 Band 7 protein DB29_02247 ENOG4105KVY Required for disulfide bond formation in some proteins (By similarity) DB29_02250 ENOG4105C1J atp-dependent rna helicase DB29_02255 ENOG4105C28 cystathionine DB29_02257 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DB29_02260 ENOG4105C84 Histidine ammonia-lyase DB29_02261 ENOG4105DWF phosphomethylpyrimidine kinase DB29_02262 ENOG4105DWD nucleoside recognition domain protein DB29_02263 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) DB29_02270 ENOG4105CK7 Sodium proline symporter DB29_02274 ENOG4108VKI Cell wall hydrolase DB29_02276 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DB29_02277 ENOG4105CZV ABC transporter DB29_02278 ENOG4108IUX (ABC) transporter DB29_02279 ENOG4105RHA ABC transporter, permease DB29_02281 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DB29_02282 ENOG4107JTW chlorite dismutase DB29_02283 ENOG4105CGU Enoyl-CoA hydratase DB29_02284 ENOG4108IJ2 phosphate acetyltransferase DB29_02285 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) DB29_02287 ENOG4105CK2 sodium dicarboxylate symporter DB29_02288 ENOG4105DCI Phosphohydrolase DB29_02291 ENOG41069HH 4-oxalocrotonate tautomerase DB29_02295 ENOG4108XFG YwhD family DB29_02297 ENOG4105DPN Oligoendopeptidase f DB29_02299 ENOG4105BZ4 penicillin-binding protein DB29_02300 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) DB29_02301 ENOG4105CYW agmatinase DB29_02304 ENOG4105C75 arginyL-tRNA synthetase DB29_02305 ENOG4105SXS Protein of unknown function (DUF456) DB29_02307 ENOG4105DF6 Fe-S oxidoreductase DB29_02309 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DB29_02310 ENOG4105C1G acyl-Coa dehydrogenase DB29_02312 ENOG4108Z1Y Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity) DB29_02313 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) DB29_02316 ENOG4105D2N Aldolase DB29_02317 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DB29_02318 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DB29_02319 ENOG4105CBT Fructose-1,6-bisphosphatase DB29_02320 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) DB29_02321 ENOG41081WG 50s ribosomal protein l31 DB29_02322 ENOG4107104 thymidine kinase DB29_02324 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase DB29_02325 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) DB29_02326 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DB29_02327 ENOG4108ZXQ stage ii sporulation protein r DB29_02329 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DB29_02331 ENOG410815N Probably functions as a manganese efflux pump (By similarity) DB29_02333 ENOG4108W2P Methyl-accepting chemotaxis DB29_02334 ENOG4108YZG isomerase DB29_02335 ENOG4108UIC UPF0340 protein DB29_02336 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) DB29_02337 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) DB29_02338 ENOG4105KD7 acetyltransferase DB29_02339 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin DB29_02342 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) DB29_02344 ENOG41082K9 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) DB29_02345 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) DB29_02346 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) DB29_02347 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) DB29_02348 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) DB29_02349 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) DB29_02353 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DB29_02355 ENOG4105FRN stage II sporulation protein DB29_02356 ENOG410839T multidrug resistance protein DB29_02357 ENOG41080TC multidrug resistance protein DB29_02358 ENOG4105MT0 Sporulation transcriptional regulator spoiiid DB29_02359 ENOG4105DFF Rod shape-determining protein mreb DB29_02361 ENOG4105CGA flagellar basal-body rod protein FlgG DB29_02364 ENOG4108B31 Spore germination protein DB29_02365 ENOG4108Q5U germination protein, ger(x)c family DB29_02368 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) DB29_02371 ENOG4105SF0 DinB family DB29_02374 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DB29_02376 ENOG410830R acetyltransferase DB29_02377 ENOG4108KGH TRANSCRIPTIONal DB29_02379 ENOG4105CMR udp-glucose 4-epimerase DB29_02380 ENOG4105CNI cell division protein FtsW DB29_02383 ENOG4107Y2X deaminase DB29_02385 ENOG4108KGH TRANSCRIPTIONal DB29_02386 ENOG4105HTX biosynthesis protein DB29_02387 ENOG4107YJ4 chain length determinant protein DB29_02388 ENOG4108RB3 Capsular polysaccharide biosynthesis protein DB29_02411 ENOG4105CS2 ec 3.2.1.21 DB29_02412 ENOG4105CID antiterminator DB29_02413 ENOG4105CID antiterminator DB29_02416 ENOG4108Z40 Transcriptional regulator DB29_02417 ENOG4108RYK Nad-dependent epimerase dehydratase DB29_02420 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DB29_02421 ENOG4105CE7 Amidase, hydantoinase carbamoylase family DB29_02424 ENOG4107SJI Dehydrogenase DB29_02425 ENOG4105BZ8 glutamate synthase DB29_02427 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DB29_02429 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component DB29_02430 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component DB29_02432 ENOG4105P4J Allophanate hydrolase, subunit 1 DB29_02434 ENOG4105C5A transporter DB29_02435 ENOG4105E7W lamb ycsf family protein DB29_02437 ENOG4108TVJ Nitroreductase DB29_02440 ENOG4105C5Y PTS System DB29_02445 ENOG4105JSC dimethylmenaquinone methyltransferase DB29_02452 ENOG4107ZUX Histidine triad (HIT) protein DB29_02453 ENOG4105J76 Periplasmic binding protein DB29_02454 ENOG4105S6R Iron-hydroxamate transporter permease subunit DB29_02456 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DB29_02459 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DB29_02461 ENOG4105XRQ Xanthine dehydrogenase accessory factor DB29_02464 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding DB29_02465 ENOG4107YV9 domain protein DB29_02467 ENOG4105C5R Aminotransferase DB29_02469 ENOG4105G9B Transcriptional regulator DB29_02471 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) DB29_02474 ENOG4105CD3 dihydroorotase DB29_02475 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DB29_02476 ENOG4108NA0 Uncharacterized conserved protein (COG2071) DB29_02488 ENOG4108V4B ThiJ pfpI DB29_02490 ENOG4105E2Y ABC, transporter DB29_02491 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DB29_02496 ENOG41082BM Transcriptional regulator, arsr family DB29_02499 ENOG4105BZG amino acid carrier protein DB29_02500 ENOG4105CHR reductase DB29_02509 ENOG4105I03 Flagellin DB29_02511 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DB29_02512 ENOG4105D3Q Sugar transferase DB29_02513 ENOG4105ER6 polysaccharide biosynthesis protein DB29_02520 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) DB29_02521 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase DB29_02522 ENOG4105C1B dTDP-glucose 4-6-dehydratase DB29_02523 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase DB29_02529 ENOG4105ECQ AraC Family Transcriptional Regulator DB29_02531 ENOG4108X0B nad(p)h dehydrogenase (quinone) DB29_02532 ENOG4105KVH Transcriptional regulator DB29_02540 ENOG4108RS6 transposase DB29_02546 ENOG4105F8D glycoside hydrolase family 4 DB29_02549 ENOG4105CK1 PTS System DB29_02550 ENOG4105VCP PTS System DB29_02552 ENOG4105RD7 BadF BadG BcrA BcrD DB29_02554 ENOG4108KAM Transcriptional regulator DB29_02556 ENOG4105DEF Extracellular solute-binding protein, family 5 DB29_02558 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DB29_02559 ENOG4105C3U ABC transporter DB29_02560 ENOG4108JQ7 (ABC) transporter DB29_02562 ENOG4105C8P )-transporter DB29_02564 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B DB29_02568 ENOG4105C4Y ABC transporter DB29_02569 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DB29_02570 ENOG4107RCV ABC transporter, permease DB29_02571 ENOG4105C2F Histidine kinase DB29_02572 ENOG4107VQW regulatoR DB29_02576 ENOG4108RVA ribokinase DB29_02578 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DB29_02589 ENOG4105EUB pirin domain protein DB29_02590 ENOG4105KVH Transcriptional regulator DB29_02591 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) DB29_02593 ENOG41075D4 Aminoglycoside 6-adenylyltransferase DB29_02594 ENOG4105WEF catalase DB29_02599 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit DB29_02600 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ DB29_02601 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DB29_02602 ENOG4105CHR reductase DB29_02604 ENOG4105CEY Amp-dependent synthetase and ligase DB29_02607 ENOG4105IE8 Alpha-ketoglutarate permease DB29_02608 ENOG4105CPQ Dehydrogenase DB29_02609 ENOG4105CHR reductase DB29_02610 ENOG4105E98 transcriptional regulator DeoR family DB29_02611 ENOG4108YZG isomerase DB29_02612 ENOG4105CMT Dihydroxyacetone kinase DB29_02613 ENOG4105CMT Dihydroxyacetone kinase DB29_02614 ENOG4105CBT Fructose-1,6-bisphosphatase DB29_02615 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DB29_02619 ENOG4108RVA ribokinase DB29_02620 ENOG4105ETE Transcriptional regulator (LacI family DB29_02621 ENOG4108Z12 YiaAB two helix domain-containing protein DB29_02635 ENOG4105EQD regulatoR DB29_02636 ENOG4105C2F Histidine kinase DB29_02637 ENOG4108IJG ABC transporter substrate-binding protein DB29_02638 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component DB29_02639 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component DB29_02640 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) DB29_02642 ENOG4105F8D glycoside hydrolase family 4 DB29_02643 ENOG4105CI1 PTS System DB29_02644 ENOG4108Q3X Transcriptional regulator DB29_02650 ENOG4105E98 transcriptional regulator DeoR family DB29_02652 ENOG41090UW PTS System DB29_02653 ENOG4105DT3 PTS system, galactitol-specific IIc component DB29_02654 ENOG4107WTH Galactitol-1-phosphate dehydrogenase DB29_02655 ENOG4105D2N Aldolase DB29_02661 ENOG4105VMP Transcriptional regulator DB29_02662 ENOG4105NX3 Membrane DB29_02663 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) DB29_02665 ENOG4105DUM transcriptional regulator, lysR family DB29_02666 ENOG4105EJ9 Membrane DB29_02667 ENOG4105C2F Histidine kinase DB29_02668 ENOG4105EQD regulatoR DB29_02672 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component DB29_02673 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component DB29_02675 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) DB29_02679 ENOG4105C5Y PTS System DB29_02683 ENOG4108NEV two component transcriptional regulator, LytTR family DB29_02687 ENOG4108IMY Transcriptional regulator DB29_02692 ENOG4105BZ1 (ABC) transporter DB29_02697 ENOG4105CJ1 ABC, transporter DB29_02700 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DB29_02701 ENOG4105BZU Histidine kinase DB29_02706 ENOG4105ECY inositol monophosphatase DB29_02714 ENOG4105ETE Transcriptional regulator (LacI family DB29_02715 ENOG4108RVA ribokinase DB29_02716 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) DB29_02717 ENOG4105C2J ABC transporter DB29_02718 ENOG4105CNN ABC, transporter DB29_02719 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator DB29_02722 ENOG4105E1F short-chain dehydrogenase reductase DB29_02728 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein DB29_02731 ENOG4105CHR reductase DB29_02733 ENOG4106V2I dimethylaminohydrolase DB29_02735 ENOG4105CJ1 ABC, transporter DB29_02737 ENOG4108NGU Transcriptional regulator DB29_02743 ENOG4107FKK extracellular solute-binding protein family 1 DB29_02745 ENOG4105EG2 ABC transporter, permease DB29_02747 ENOG4105C4C beta-galactosidase DB29_02750 ENOG4107S4Y M20 DapE family protein YgeY DB29_02751 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain DB29_02752 ENOG4105W1Y Transcriptional regulator DB29_02756 ENOG4108Z0Z intracellular protease Pfpi family DB29_02758 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC DB29_02760 ENOG4105CTQ phosphohexokinase DB29_02761 ENOG4108XBJ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) DB29_02767 ENOG4107YY3 extracellular solute-binding protein family 1 DB29_02768 ENOG4105C19 ABC transporter DB29_02776 ENOG410874W AraC family transcriptional regulator DB29_02780 ENOG4105NIV Esterase DB29_02783 ENOG4108HWY Beta-lactamase DB29_02786 ENOG4105C8Q Methyl-accepting chemotaxis DB29_02787 ENOG4105ETE Transcriptional regulator (LacI family DB29_02789 ENOG4108V5C ABC transporter DB29_02790 ENOG41075H3 AraC family transcriptional regulator DB29_02796 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component DB29_02797 ENOG4107QP6 Xylose isomerase domain protein TIM barrel DB29_02800 ENOG4105WH1 Two component transcriptional regulator luxr family DB29_02805 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) DB29_02806 ENOG4106SCS STAS domain DB29_02811 ENOG41073R8 VanW family DB29_02813 ENOG4108RAV Conserved protein DB29_02820 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DB29_02829 ENOG4105E2R ROK family DB29_02831 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component DB29_02832 ENOG4105DRS transport system, permease DB29_02833 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) DB29_02834 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) DB29_02836 ENOG4105EBM Alpha Beta Hydrolase Fold protein DB29_02838 ENOG4105DTD Dehydrogenase DB29_02840 ENOG4105C0R drug resistance transporter emrb qaca subfamily DB29_02841 ENOG4108JGH Tetr family transcriptional regulator DB29_02842 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DB29_02843 ENOG4105E2A Dehydrogenase DB29_02845 ENOG4105S6R Iron-hydroxamate transporter permease subunit DB29_02847 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) DB29_02848 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) DB29_02851 ENOG4105E0A ABC, transporter DB29_02852 ENOG4105KFN sortase, SrtB family DB29_02854 ENOG4105C37 (CBS) domain DB29_02857 ENOG4105WEF catalase DB29_02859 ENOG4105E2A Dehydrogenase DB29_02861 ENOG4105EXQ uroporphyrinogen iii synthase hem4 DB29_02864 ENOG4105DVE abc transporter atp-binding protein DB29_02867 ENOG41067SE Tetr family transcriptional regulator DB29_02873 ENOG4105H67 Protein of unknown function (DUF421) DB29_02875 ENOG4108KSA LysR family transcriptional regulator DB29_02876 ENOG4108UZX fmn reductase DB29_02877 ENOG4105CPU Monooxygenase DB29_02879 ENOG4105E2Y ABC, transporter DB29_02880 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) DB29_02881 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein DB29_02882 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DB29_02883 ENOG4107R37 Glutamate dehydrogenase DB29_02884 ENOG4105C5Q Transcriptional regulator DB29_02885 ENOG4105KTU Transcriptional regulator, arsr family DB29_02886 ENOG4105PGM cation diffusion facilitator family transporter DB29_02887 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) DB29_02888 ENOG4105H08 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DB29_02890 ENOG4105CHR reductase DB29_02891 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) DB29_02892 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) DB29_02894 ENOG4105ETE Transcriptional regulator (LacI family DB29_02902 ENOG4105ENE Histidine kinase DB29_02903 ENOG4105WH1 Two component transcriptional regulator luxr family DB29_02904 ENOG4105E0C molybdate abc transporter DB29_02905 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DB29_02906 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) DB29_02908 ENOG4106Z5D Glycoside Hydrolase Family 43 DB29_02913 ENOG4105EY8 ABC transporter DB29_02914 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain DB29_02916 ENOG4105CN9 Peptidase m42 family protein DB29_02923 ENOG4105CG6 trap dicarboxylate transporter dctm subunit DB29_02924 ENOG41080HJ 6-phospho 3-hexuloisomerase DB29_02925 ENOG4105E66 phosphoriboisomerase A DB29_02927 ENOG4108VA3 3-hexulose-6-phosphate synthase DB29_02929 ENOG4105C59 p-type ATPase DB29_02932 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) DB29_02933 ENOG4105DT3 PTS system, galactitol-specific IIc component DB29_02934 ENOG4105CPQ Dehydrogenase DB29_02939 ENOG41090UD (LipO)protein DB29_02940 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DB29_02944 ENOG4108S01 response regulator DB29_02945 ENOG4105BZU Histidine kinase DB29_02948 ENOG4105CGP Urocanate hydratase DB29_02949 ENOG4105CI2 imidazolone-5-propionate hydrolase DB29_02951 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) DB29_02952 ENOG4105DWD nucleoside recognition domain protein DB29_02957 ENOG4107TVP HD domain protein DB29_02968 ENOG4105CUT histidyl-tRNA synthetase DB29_02970 ENOG4107BMA Transglycosylase associated protein DB29_02973 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase DB29_02979 ENOG4105DRS transport system, permease DB29_02981 ENOG4105D0M Protease HtpX homolog DB29_02983 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DB29_02985 ENOG4105E0M Sulfatase DB29_02988 ENOG4105FQP Beta-lactamase DB29_02989 ENOG4105JAB phenazine biosynthesis protein, phzf family DB29_02991 ENOG4107RJ5 oxidoreductase DB29_02992 ENOG4106HBX Transcriptional Regulator AraC Family DB29_02994 ENOG4105CK5 oxidoreductase DB29_02995 ENOG4108IJG ABC transporter substrate-binding protein DB29_02996 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component DB29_02997 ENOG4105DRS transport system, permease DB29_02999 ENOG4105UEI Transcriptional Regulator AraC Family DB29_03001 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) DB29_03002 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF DB29_03003 ENOG4105EP8 Glycosyl Hydrolase Family 88 DB29_03004 ENOG4105D56 permease protein DB29_03005 ENOG4105DRS transport system, permease DB29_03010 ENOG4108M26 parallel beta-helix repeat protein DB29_03012 ENOG4108RZE Tetr family transcriptional regulator DB29_03019 ENOG4105CQ4 Transcriptional regulator DB29_03022 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DB29_03024 ENOG4105DG6 mannose-6-phosphate isomerase DB29_03027 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DB29_03028 ENOG4105DEU major facilitator superfamily DB29_03030 ENOG4105CQB FAD linked oxidase domain protein DB29_03031 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DB29_03035 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 DB29_03036 ENOG4108U05 Transcriptional regulator DB29_03040 ENOG4105KRI phosphocarrier protein (HPr DB29_03043 ENOG410787A Pts system, glucitol sorbitol-specific DB29_03044 ENOG4105DZY Pts system, glucitol sorbitol-specific DB29_03046 ENOG4105DKT Transcriptional regulator DB29_03048 ENOG4105C59 p-type ATPase DB29_03051 ENOG4105C19 ABC transporter DB29_03052 ENOG4105EWM Histidine kinase DB29_03055 ENOG4105EVU fructokinase DB29_03058 ENOG4105JQZ Methyltransferase DB29_03059 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase DB29_03060 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) DB29_03062 ENOG4105E0M Sulfatase DB29_03066 ENOG4105I1K ABC transporter DB29_03071 ENOG4105CPN adenine deaminase DB29_03072 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DB29_03073 ENOG4108I5D sulfate abc transporter DB29_03074 ENOG4105F38 ABC transporter, permease DB29_03075 ENOG4105DU0 nucleoside hydrolase DB29_03080 ENOG4107YZX Universal stress protein DB29_03081 ENOG4105HX0 Transcriptional regulator DB29_03082 ENOG4105DE4 1-phosphofructokinase DB29_03083 ENOG4105DM4 PTS System DB29_03084 ENOG4105DM4 PTS System DB29_03085 ENOG4105D2N Aldolase DB29_03087 ENOG4108W5N phosphatidylglycerophosphatase a DB29_03090 ENOG41069B3 Small, acid-soluble spore protein Tlp DB29_03091 ENOG4107V2S Transcriptional regulator DB29_03092 ENOG4108WS4 fmn reductase DB29_03094 ENOG4107Z3H Transcriptional regulator, TetR family DB29_03095 ENOG4107QWP ABC-2 type transporter DB29_03096 ENOG4105CJ1 ABC, transporter DB29_03101 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B DB29_03102 ENOG4105CFC Transporter DB29_03104 ENOG4108Z4U Ferredoxin DB29_03110 ENOG4105E2K Glycosyl transferase (Group 1 DB29_03113 ENOG4105C6Y Udp-glucose 6-dehydrogenase DB29_03116 ENOG4105ESV Glycosyl transferase, family 4 DB29_03136 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DB29_03138 ENOG4105D03 DNA-3-methyladenine glycosylase II DB29_03139 ENOG4105CIB oxidoreductase Domain protein DB29_03140 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DB29_03141 ENOG410667J hydrolase DB29_03143 ENOG4105D29 Helix-turn-helix type 11 domain protein DB29_03145 ENOG4105UBK short-chain dehydrogenase reductase DB29_03146 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) DB29_03148 ENOG4105WH1 Two component transcriptional regulator luxr family DB29_03149 ENOG4105BZU Histidine kinase DB29_03154 ENOG41062ES Transcriptional regulator DB29_03156 ENOG4108UHU Aldolase DB29_03159 ENOG4105CZV ABC transporter DB29_03160 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DB29_03165 ENOG4108IMY Transcriptional regulator DB29_03167 ENOG4105D17 glycoside hydrolase, family 3 domain protein DB29_03170 ENOG4105DRS transport system, permease DB29_03174 ENOG4105ETE Transcriptional regulator (LacI family DB29_03176 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component DB29_03178 ENOG4108HKT sucrose-6-phosphate hydrolase DB29_03179 ENOG4108HKT sucrose-6-phosphate hydrolase DB29_03180 ENOG41061TZ Short-chain dehydrogenase reductase Sdr DB29_03181 ENOG4105VRS hydrolase family 18 DB29_03184 ENOG4105U6W MutT NUDIX family protein DB29_03185 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DB29_03186 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DB29_03187 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) DB29_03191 ENOG4107SJB teichoic acid biosynthesis DB29_03193 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase DB29_03194 ENOG4107SJB teichoic acid biosynthesis DB29_03195 ENOG4107VDP teichoic acid biosynthesis DB29_03196 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DB29_03198 ENOG4108KGH TRANSCRIPTIONal DB29_03201 ENOG4108JQ7 (ABC) transporter DB29_03202 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DB29_03204 ENOG4108J59 Extracellular solute-binding protein, family 5 DB29_03206 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein DB29_03209 ENOG4105EPR degv family DB29_03216 ENOG4105E1Q flagellar hook-associated protein DB29_03217 ENOG4105DTJ flagellar hook-associated protein DB29_03218 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) DB29_03219 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) DB29_03220 ENOG41083S7 flagellar protein FlaG DB29_03221 ENOG4107RT6 flagellar hook-associated DB29_03222 ENOG4105MQ3 flagellar protein FliS DB29_03225 ENOG4105VEQ Cold shock protein DB29_03226 ENOG4105MS2 ribosomal subunit Interface protein DB29_03227 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving DB29_03228 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) DB29_03230 ENOG4105CAK Cell division ATP-binding protein ftsE DB29_03231 ENOG4105CRP Part of the ABC transporter FtsEX involved in DB29_03232 ENOG4105DR5 peptidase DB29_03233 ENOG4105CN1 protease DB29_03237 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) DB29_03238 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DB29_03239 ENOG4108PY7 DB29_03240 ENOG41086DT Membrane protein of unknown function DB29_03241 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) DB29_03242 ENOG4107UGP Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) DB29_03243 ENOG4105HKU nucleoside recognition domain-containing protein DB29_03244 ENOG4107XGZ Hydrolase DB29_03245 ENOG4108S4C acetyltransferase DB29_03246 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) DB29_03247 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) DB29_03248 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) DB29_03249 ENOG4105ECC imidazole-glycerol-phosphate dehydratase DB29_03250 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) DB29_03251 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase DB29_03252 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) DB29_03253 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase DB29_03255 ENOG4108UZ3 Transporter DB29_03259 ENOG4105C3M thioredoxin reductase DB29_03260 ENOG4108Z4K mutator MutT protein DB29_03261 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) DB29_03262 ENOG4105CHW UPF0052 protein DB29_03263 ENOG4105CIE May be required for sporulation (By similarity) DB29_03264 ENOG4105KRI phosphocarrier protein (HPr DB29_03265 ENOG4105R40 Glycine betaine carnitine choline DB29_03266 ENOG4108HQR Glycine betaine DB29_03267 ENOG4105E90 ABC transporter DB29_03268 ENOG4108IJ8 ABC transporter DB29_03270 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) DB29_03271 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DB29_03272 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DB29_03278 ENOG4105BZA Phosphoglycerate kinase DB29_03279 ENOG4105CP7 Triose-phosphate isomerase DB29_03280 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DB29_03281 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) DB29_03282 ENOG4105DRR Transcriptional regulator, GntR family DB29_03283 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DB29_03284 ENOG4105C26 Dehydrogenase DB29_03285 ENOG4105DTQ mandelate racemase muconate lactonizing DB29_03290 ENOG4105XZU Preprotein translocase, subunit SecG DB29_03291 ENOG4105DEN Luciferase family DB29_03294 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) DB29_03295 ENOG4108VGI doxx family DB29_03296 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) DB29_03300 ENOG4105DWD nucleoside recognition domain protein DB29_03301 ENOG4108JPW Aminotransferase DB29_03302 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold DB29_03304 ENOG4108ZJ4 polysaccharide deacetylase DB29_03306 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) DB29_03309 ENOG4105CHU acetyl-coa acetyltransferase DB29_03310 ENOG4105C1G acyl-Coa dehydrogenase DB29_03311 ENOG41080E8 Transcriptional regulator, Spx MgsR family DB29_03312 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) DB29_03314 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DB29_03315 ENOG4108UMI ABC transporter, permease DB29_03316 ENOG4105D01 (LipO)protein DB29_03318 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) DB29_03321 ENOG4105C3K feS assembly ATPase SufC DB29_03322 ENOG4105JRK feS assembly protein SufD DB29_03324 ENOG4108UNV SUF system FeS assembly protein, NifU family DB29_03325 ENOG4105DIW FeS assembly protein SUFB DB29_03328 ENOG4105CID antiterminator DB29_03329 ENOG4105CS2 ec 3.2.1.21 DB29_03330 ENOG4105CS2 ec 3.2.1.21 DB29_03331 ENOG4105DMQ Methyltransferase DB29_03332 ENOG4105CPC Aldo Keto reductase DB29_03333 ENOG410874W AraC family transcriptional regulator DB29_03343 ENOG4105I3N Conserved Protein DB29_03345 ENOG4107R8B 5'-nucleotidase DB29_03346 ENOG4105KZD Domain of unknown function (DUF1805) DB29_03347 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) DB29_03348 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) DB29_03349 ENOG4108YTE sporulation protein YunB DB29_03350 ENOG4107S6Z Na H antiporter DB29_03351 ENOG4105FAA peptidase M23 DB29_03352 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) DB29_03353 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) DB29_03354 ENOG4105MMD transcriptional regulator DB29_03357 ENOG4105D4U had-superfamily hydrolase, subfamily iia DB29_03358 ENOG4108W5N phosphatidylglycerophosphatase a DB29_03360 ENOG4105D6E homoserine dehydrogenase DB29_03361 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) DB29_03362 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) DB29_03363 ENOG41083MR nifu domain-containing protein DB29_03366 ENOG4105ZKE UPF0349 protein DB29_03368 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) DB29_03369 ENOG4105DVY radical SAM domain protein DB29_03371 ENOG4108YX9 iron--sulfur cluster insertion protein erpA DB29_03372 ENOG4105E5Q amino acid AbC transporter DB29_03373 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein DB29_03376 ENOG4105ETD TRANSCRIPTIONal DB29_03377 ENOG4105JF0 Phosphoenolpyruvate-dependent sugar phosphotransferase system, eiia 2 DB29_03378 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase DB29_03379 ENOG4105CAY ferredoxin--nadp reductase DB29_03380 ENOG4105CEP NADH dehydrogenase DB29_03382 ENOG41069ER domain protein DB29_03384 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) DB29_03386 ENOG4108RS6 transposase DB29_03388 ENOG4105K70 DNA-binding protein DB29_03389 ENOG4107U9T Pfam:Ribonuclease_BN DB29_03390 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) DB29_03391 ENOG4108ZB6 transcriptional regulator AsnC family DB29_03392 ENOG4105CHM Aminotransferase DB29_03393 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase DB29_03396 ENOG4105WG9 Conserved Protein DB29_03398 ENOG4107QW4 alcohol dehydrogenase DB29_03399 ENOG4105CPF Cell wall formation (By similarity) DB29_03400 ENOG4107QYV phosphohexose isomerase DB29_03403 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase DB29_03404 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) DB29_03406 ENOG4107PKG Protein of unknown function (DUF1516) DB29_03410 ENOG410841Q phosphoesterase PA-phosphatase related protein DB29_03411 ENOG4105DHS permease protein DB29_03412 ENOG4105CM4 permease protein DB29_03413 ENOG4108IPW abc transporter atp-binding protein DB29_03415 ENOG4108RS6 transposase DB29_03417 ENOG4105ZMH deoxynucleoside kinase DB29_03419 ENOG4105C87 Aminotransferase class I and II DB29_03424 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component DB29_03426 ENOG4105D2X ABC transporter substrate-binding protein DB29_03429 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase DB29_03430 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP DB29_03431 ENOG4108Z0R Transferase DB29_03432 ENOG4105E8V Alpha Beta Hydrolase Fold protein DB29_03433 ENOG4108V2W Carbonate dehydratase DB29_03436 ENOG410605W Major Facilitator DB29_03437 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DB29_03438 ENOG4105C8T Leucyl-tRNA synthetase DB29_03443 ENOG4105CBX hi0933 family DB29_03445 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme DB29_03446 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein DB29_03448 ENOG4105CNI cell division protein FtsW DB29_03449 ENOG4105CNI cell division protein FtsW DB29_03451 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) DB29_03452 ENOG4108IXY short-chain dehydrogenase reductase DB29_03453 ENOG4105VUF Transcriptional regulator DB29_03454 ENOG41086D8 Transcriptional regulator DB29_03455 ENOG4105C6T cysteine synthase DB29_03458 ENOG41067MG lrgb family DB29_03461 ENOG4107RUY (E1 component), alpha subunit DB29_03463 ENOG4107QKR Dehydrogenase DB29_03466 ENOG4107EXU Short-chain dehydrogenase reductase Sdr DB29_03467 ENOG4105CIY formyltetrahydrofolate deformylase DB29_03469 ENOG4108V15 phosphotransferase enzyme family DB29_03471 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) DB29_03475 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ DB29_03480 ENOG4108VDD TRNA binding domain protein DB29_03482 ENOG4105DFU Cell wall formation (By similarity) DB29_03485 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase DB29_03486 ENOG4105ETE Transcriptional regulator (LacI family DB29_03487 ENOG4105DGU Histone deacetylase DB29_03488 ENOG4105W87 Cbs domain DB29_03489 ENOG4105F1V Acetoin utilization protein DB29_03491 ENOG4105BZ4 penicillin-binding protein DB29_03492 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DB29_03493 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) DB29_03496 ENOG4105U5Y Transcriptional regulator DB29_03497 ENOG4108W76 histidinol phosphate phosphatase hisj family DB29_03498 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) DB29_03500 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) DB29_03502 ENOG4105D07 Signal peptide peptidase, SppA DB29_03503 ENOG4105VK3 rdd domain containing protein DB29_03505 ENOG4105KBJ sporulation protein ytfj DB29_03506 ENOG4105CZM Major Facilitator DB29_03507 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) DB29_03509 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) DB29_03510 ENOG4105EQI Metal Dependent Phosphohydrolase DB29_03512 ENOG4105CDH Citrulline--aspartate ligase DB29_03513 ENOG4105CH7 arginosuccinase DB29_03518 ENOG4105DC7 peptidase M24 DB29_03519 ENOG4105E8R UPF0173 metal-dependent hydrolase DB29_03523 ENOG4105SFS phosphoesterase RecJ domain protein DB29_03525 ENOG4105VV2 DB29_03526 ENOG4105C0B DNA polymerase III (alpha subunit) DB29_03527 ENOG4105C6K Malic enzyme DB29_03528 ENOG4107YCY Transcriptional regulator DB29_03529 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) DB29_03530 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) DB29_03531 ENOG4105CTQ phosphohexokinase DB29_03532 ENOG4105CA9 Pyruvate kinase DB29_03533 ENOG4105FS0 cytoplasmic membrane protein DB29_03535 ENOG4105BZN citrate synthase DB29_03536 ENOG4108HMX isocitrate dehydrogenase (NADP) DB29_03537 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DB29_03538 ENOG4105FKN transcriptional regulator, AsnC family DB29_03539 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DB29_03540 ENOG4105BZU Histidine kinase DB29_03541 ENOG4105C2M dna polymerase I DB29_03542 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) DB29_03544 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) DB29_03545 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DB29_03546 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) DB29_03548 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) DB29_03551 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) DB29_03553 ENOG4105C22 threonyL-tRNA synthetase DB29_03556 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family DB29_03559 ENOG4105C19 ABC transporter DB29_03560 ENOG4107RBB ABC transporter, permease DB29_03561 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) DB29_03562 ENOG4105VJV 50s ribosomal protein L35 DB29_03563 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) DB29_03567 ENOG4105CN9 Peptidase m42 family protein DB29_03571 ENOG4108RWN rrna methyltransferase DB29_03573 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) DB29_03574 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) DB29_03576 ENOG4105DCG PHP domain protein DB29_03577 ENOG4105C98 muts2 protein DB29_03579 ENOG4105CEY Amp-dependent synthetase and ligase DB29_03580 ENOG4107Z3H Transcriptional regulator, TetR family DB29_03581 ENOG41060WC Enoyl-CoA hydratase DB29_03582 ENOG4105BZJ Electron transfer flavoprotein DB29_03583 ENOG4105C10 Electron transfer flavoprotein DB29_03584 ENOG4105K63 Thioredoxin DB29_03585 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) DB29_03588 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit DB29_03590 ENOG4105E33 succinate dehydrogenase DB29_03592 ENOG4105PFC Transcriptional regulator DB29_03593 ENOG4105KRI phosphocarrier protein (HPr DB29_03594 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) DB29_03595 ENOG41067TZ transcriptional regulator, MarR family DB29_03596 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) DB29_03597 ENOG4108Z4U Ferredoxin DB29_03598 ENOG4105C72 UPF0176 protein DB29_03599 ENOG4108XJQ germination protein DB29_03600 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) DB29_03601 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) DB29_03602 ENOG4105M59 Phosphodiesterase, mj0936 family DB29_03603 ENOG4107STQ Multicopper oxidase DB29_03606 ENOG4105C01 Dihydroxy-acid dehydratase DB29_03608 ENOG4105C7K acetolactate synthase DB29_03609 ENOG4108ZP8 Acetolactate synthase small subunit DB29_03610 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase DB29_03611 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) DB29_03612 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DB29_03613 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DB29_03614 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DB29_03616 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation DB29_03617 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) DB29_03618 ENOG4108IUQ atp-dependent protease DB29_03619 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) DB29_03620 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) DB29_03621 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) DB29_03623 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) DB29_03625 ENOG4105D52 delta-aminolevulinic acid dehydratase DB29_03626 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase DB29_03627 ENOG41068KH stage VI sporulation protein D DB29_03627 ENOG41068KH stage VI sporulation protein D DB29_03632 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) DB29_03633 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase DB29_03634 ENOG4106A3R peptidase DB29_03636 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein DB29_03638 ENOG4105W5Q DNA repair protein (RadC DB29_03639 ENOG4105DFF Rod shape-determining protein mreb DB29_03640 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) DB29_03641 ENOG4105YHC Rod shape-determining protein MreD DB29_03643 ENOG4107QMS site-determining protein DB29_03644 ENOG4107RKG DJ-1/PfpI family DB29_03646 ENOG4107ZYJ bioY protein DB29_03647 ENOG4105CPC Aldo Keto reductase DB29_03650 ENOG4105C03 ribonuclease DB29_03651 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) DB29_03652 ENOG4105X36 (ribosomal) protein DB29_03653 ENOG4105K46 50S ribosomal protein l27 DB29_03654 ENOG4105KRN Transcriptional regulator, abrb family DB29_03655 ENOG4105CI2 imidazolone-5-propionate hydrolase DB29_03657 ENOG4108UN4 phage SPO1 DNA polymerase-related protein DB29_03658 ENOG4107VFR oxidoreductase DB29_03663 ENOG4105CVA phosphate DB29_03664 ENOG4105C8U phosphate abc transporter DB29_03665 ENOG4105E2Z phosphate ABC transporter (Permease DB29_03666 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DB29_03667 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DB29_03671 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination DB29_03672 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation DB29_03673 ENOG4105CBS Chea signal transduction histidine kinase DB29_03674 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis DB29_03675 ENOG4105CAQ asparagine synthetase DB29_03681 ENOG4107TUM Amidinotransferase DB29_03682 ENOG4108HNZ carboxyl transferase DB29_03684 ENOG4105VFE sira family DB29_03686 ENOG4108MXZ Esterase DB29_03687 ENOG4107AYK membrAne DB29_03690 ENOG4105C0D helicase DB29_03695 ENOG4108KP7 hydrolase DB29_03697 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase DB29_03699 ENOG4105CAS nag kinase DB29_03700 ENOG4105C8Y Acetylornithine aminotransferase DB29_03701 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain DB29_03702 ENOG4108K60 carbamoyl-phosphate synthetase ammonia chain DB29_03703 ENOG4105DBV ornithine carbamoyltransferase DB29_03707 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) DB29_03710 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DB29_03711 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DB29_03714 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate DB29_03716 ENOG4105F0V Cell wall hydrolase DB29_03717 ENOG4105K4I Scp-like extracellular DB29_03718 ENOG4105CS9 pantothenic acid kinase DB29_03723 ENOG4105C31 Tryptophanyl-tRNA synthetase DB29_03727 ENOG4108UT2 hemolysin iii DB29_03736 ENOG4106H6A DB29_03737 ENOG4108Z18 K06886 hemoglobin DB29_03739 ENOG4105E4C Lytic transglycosylase catalytic DB29_03740 ENOG4105MIX Adenylate cyclase DB29_03743 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DB29_03744 ENOG4105EMS pseudouridine synthase DB29_03747 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) DB29_03756 ENOG4105ENA helicase DB29_03759 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) DB29_03760 ENOG4106855 Competence protein DB29_03767 ENOG4105C5X domain protein DB29_03770 ENOG4105C0D helicase DB29_03771 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) DB29_03772 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor DB29_03773 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor DB29_03774 ENOG4105WZW rhodanese family DB29_03775 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) DB29_03776 ENOG4105EEM helicase DB29_03777 ENOG4105F0I Aminotransferase DB29_03778 ENOG4105F6S Spore photoproduct lyase DB29_03779 ENOG41080S5 HTH_DTXR DB29_03783 ENOG4105DC7 peptidase M24 DB29_03784 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) DB29_03785 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) DB29_03789 ENOG4105CD2 stage iii sporulation protein aa DB29_03790 ENOG4105KR5 Stage iii sporulation protein DB29_03791 ENOG4108CQH stage III sporulation protein AC DB29_03792 ENOG4105KQ4 Stage iii sporulation protein ad DB29_03794 ENOG410644B Stage III sporulation protein af DB29_03799 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DB29_03800 ENOG4108ZSR alkaline shock protein DB29_03801 ENOG4105M7K Involved in the transcription termination process (By similarity) DB29_03802 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) DB29_03804 ENOG4105CTB Polyprenyl synthetase DB29_03805 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) DB29_03806 ENOG4105DX0 Hemolysin A DB29_03808 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) DB29_03809 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) DB29_03810 ENOG4105S1Z Stage IV sporulation protein B DB29_03811 ENOG4107QQR Sporulation DB29_03814 ENOG4106CCJ Protein of unknown function (DUF2627) DB29_03815 ENOG4108JUB Transcriptional regulator DB29_03816 ENOG4107RDP Dehydrogenase DB29_03819 ENOG4105CPP Dehydrogenase, E1 component DB29_03820 ENOG4105C7S Dehydrogenase DB29_03823 ENOG4108X4Q Hydrolase DB29_03825 ENOG4105VPX protein, conserved in bacteria DB29_03826 ENOG410681U heavy metal transport detoxification protein DB29_03828 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DB29_03834 ENOG4105D64 Mechanosensitive ion channel DB29_03837 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) DB29_03838 ENOG4105C8Y Acetylornithine aminotransferase DB29_03839 ENOG4105CH2 amidohydrolase DB29_03841 ENOG4105D8X mechanosensitive ion channel DB29_03842 ENOG4105D3R alkyl hydroperoxide reductase DB29_03843 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DB29_03844 ENOG4107ZYR domain protein DB29_03845 ENOG4105CN5 Metallo-Beta-Lactamase DB29_03847 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DB29_03851 ENOG4105CPP Dehydrogenase, E1 component DB29_03852 ENOG4105C7S Dehydrogenase DB29_03854 ENOG4105C3U ABC transporter DB29_03855 ENOG4108JQ7 (ABC) transporter DB29_03858 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DB29_03860 ENOG4105C94 Transporter DB29_03865 ENOG4105CXN decarboxylase DB29_03867 ENOG4108WQ8 UPF0637 protein DB29_03868 ENOG4105ECY inositol monophosphatase DB29_03870 ENOG4105CI3 gtp-binding protein typa DB29_03872 ENOG4105QA2 DB29_03874 ENOG4108IAB Phoh family DB29_03877 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) DB29_03878 ENOG4107VFP cytochrome oxidase assembly DB29_03879 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) DB29_03880 ENOG4105BZ9 Cytochrome C oxidase, subunit I DB29_03881 ENOG4107QS1 Cytochrome C Oxidase, Subunit III DB29_03882 ENOG41064X9 cytochrome C oxidase subunit IV DB29_03883 ENOG4108SJC Membrane DB29_03886 ENOG4106UY4 Inherit from COG: Scp-like extracellular DB29_03893 ENOG4105WUC UPF0298 protein DB29_03895 ENOG4106H78 methyltransferase DB29_03896 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) DB29_03897 ENOG4105H20 Sporulation integral membrane protein YlbJ DB29_03898 ENOG4105D78 K07001 NTE family protein DB29_03899 ENOG41063PX domain protein DB29_03900 ENOG4105CDE UPF0348 protein DB29_03901 ENOG4105KNH Nucleic acid-binding protein DB29_03903 ENOG4108YG3 N-acetyltransferase DB29_03904 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) DB29_03906 ENOG41074B2 UPF0747 protein DB29_03907 ENOG4108V6E Cell division protein mraZ DB29_03908 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) DB29_03910 ENOG4105CJN penicillin-binding protein DB29_03911 ENOG4105CJN penicillin-binding protein DB29_03912 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) DB29_03913 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) DB29_03914 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) DB29_03915 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) DB29_03917 ENOG4105CNI cell division protein FtsW DB29_03918 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) DB29_03919 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) DB29_03920 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) DB29_03921 ENOG4108AWX Sporulation factor SpoIIGA DB29_03922 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DB29_03924 ENOG4105WR5 sporulation protein, YlmC YmxH family DB29_03925 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase DB29_03926 ENOG4105DFA alanine racemase domain protein DB29_03928 ENOG41067XK integral membrane protein DB29_03929 ENOG4105DBK s4 domain protein DB29_03933 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) DB29_03934 ENOG4105C34 Pseudouridine synthase DB29_03935 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) DB29_03937 ENOG4105CXT aspartate transcarbamylase DB29_03938 ENOG4105CD3 dihydroorotase DB29_03939 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain DB29_03940 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain DB29_03941 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) DB29_03942 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) DB29_03943 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) DB29_03944 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) DB29_03947 ENOG4105EJV Membrane DB29_03948 ENOG4105F23 Fibronectin-binding protein DB29_03951 ENOG4105KC4 UPF0296 protein DB29_03952 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) DB29_03954 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase DB29_03955 ENOG4105C25 Primosomal protein n' DB29_03956 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) DB29_03957 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B DB29_03958 ENOG4108ZF3 Phosphatase DB29_03959 ENOG4105D9P serine threonine protein kinase DB29_03960 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) DB29_03961 ENOG4105DJV ribulose-phosphate 3-epimerase DB29_03963 ENOG4105VB9 50S ribosomal protein l28 DB29_03964 ENOG4108ZAA Alkaline-shock protein DB29_03965 ENOG4105DP4 dak2 domain fusion protein ylov DB29_03966 ENOG4105EPR degv family DB29_03968 ENOG4105EJQ L-serine dehydratase DB29_03969 ENOG4105CB5 ATP-dependent DNA helicase recG DB29_03970 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) DB29_03971 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) DB29_03972 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DB29_03973 ENOG4105CHR reductase DB29_03974 ENOG410854A Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) DB29_03975 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) DB29_03977 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) DB29_03978 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) DB29_03979 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) DB29_03980 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) DB29_03982 ENOG4105K5M 30s ribosomal protein S16 DB29_03983 ENOG4105VB6 UPF0109 protein DB29_03985 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) DB29_03986 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) DB29_03987 ENOG4105C75 arginyL-tRNA synthetase DB29_03988 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) DB29_03991 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) DB29_03993 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DB29_03996 ENOG4105CMV Succinyl-CoA synthetase subunit beta DB29_03997 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha DB29_03998 ENOG4105C79 DNA protecting protein DprA DB29_03999 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DB29_04000 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) DB29_04001 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DB29_04002 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) DB29_04003 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) DB29_04004 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) DB29_04005 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) DB29_04006 ENOG4108ZC9 flagellar basal-body rod protein flgc DB29_04007 ENOG4105VQ0 flagellar hook-basal body complex protein fliE DB29_04008 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) DB29_04009 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DB29_04015 ENOG410822I Flagellar hook capping protein DB29_04016 ENOG4108JQA flagellar DB29_04019 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DB29_04020 ENOG4105DD5 Flagellar motor switch protein DB29_04021 ENOG4107YTP response regulator receiver protein DB29_04023 ENOG4105CN7 Flagellar biosynthetic protein FliP DB29_04024 ENOG4105VS8 Flagellar biosynthetic protein fliq DB29_04025 ENOG4105D19 Role in flagellar biosynthesis (By similarity) DB29_04026 ENOG4105D00 flagellar biosynthetic protein flhB DB29_04027 ENOG4105D7B Flagellar biosynthesis protein flha DB29_04028 ENOG4105FZW flagellar biosynthesis regulator FlhF DB29_04030 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) DB29_04032 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) DB29_04033 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DB29_04035 ENOG4105CE9 30S ribosomal protein S2 DB29_04036 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) DB29_04037 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) DB29_04038 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) DB29_04039 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) DB29_04040 ENOG4105KNE Phosphatidate cytidylyltransferase DB29_04041 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) DB29_04042 ENOG4105DZP Membrane-associated zinc metalloprotease DB29_04043 ENOG4107QP0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) DB29_04044 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DB29_04045 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) DB29_04046 ENOG4105CHV Transcription elongation factor NusA DB29_04047 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination DB29_04048 ENOG4105VHM ribosomal protein DB29_04049 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) DB29_04051 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) DB29_04052 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) DB29_04053 ENOG4105DTN riboflavin biosynthesis protein ribF DB29_04055 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) DB29_04056 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) DB29_04058 ENOG4105C1V Peptidase, M16 DB29_04060 ENOG4105E35 Dipicolinate synthase subunit A DB29_04061 ENOG4108S0H Dipicolinic acid synthetase, b subunit DB29_04062 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DB29_04064 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DB29_04066 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit DB29_04068 ENOG4105CNU cell division protein FtsK DB29_04069 ENOG4105FDP GntR family transcriptional regulator DB29_04072 ENOG4108RKS Short-chain dehydrogenase reductase Sdr DB29_04073 ENOG4105XZV Protein of unknown function (DUF3243) DB29_04076 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase DB29_04077 ENOG4105CEV competence damage-inducible protein DB29_04078 ENOG4105C1J atp-dependent rna helicase DB29_04079 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) DB29_04084 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) DB29_04085 ENOG4105D48 metallophosphoesterase DB29_04086 ENOG4105MCT stage V sporulation protein S DB29_04088 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DB29_04091 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) DB29_04092 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) DB29_04093 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) DB29_04095 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) DB29_04096 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) DB29_04099 ENOG4106F1P AAA ATPase, central domain protein DB29_04100 ENOG4105CXI aluminum resistance protein DB29_04101 ENOG4105C5F glutamine synthetase DB29_04104 ENOG4105CQB FAD linked oxidase domain protein DB29_04105 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DB29_04106 ENOG4105CQB FAD linked oxidase domain protein DB29_04107 ENOG4105C82 Malate synthase DB29_04108 ENOG4105ERH Fumarylacetoacetate hydrolase DB29_04109 ENOG4107HP6 Transcriptional regulator DB29_04112 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DB29_04114 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) DB29_04116 ENOG4108SVB resolvase DB29_04118 ENOG4105VPS UPF0291 protein DB29_04119 ENOG4105CV1 Transketolase (EC 2.2.1.1) DB29_04121 ENOG4105VXM UPF0154 protein DB29_04122 ENOG4105BZ1 (ABC) transporter DB29_04123 ENOG4105BZ1 (ABC) transporter DB29_04127 ENOG4108I0Z Aconitate hydratase DB29_04134 ENOG4106F1P AAA ATPase, central domain protein DB29_04136 ENOG4107RA1 nh(3)-dependent nad( ) synthetase DB29_04140 ENOG4105EPM Diguanylate phosphodiesterase DB29_04145 ENOG4107R88 Chemotaxis protein (CheV) DB29_04147 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) DB29_04151 ENOG4105BZ9 Cytochrome C oxidase, subunit I DB29_04153 ENOG41060D1 Quinol oxidase DB29_04155 ENOG41084AG Acylphosphatase DB29_04156 ENOG4105BZG amino acid carrier protein DB29_04158 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) DB29_04159 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase DB29_04160 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) DB29_04161 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) DB29_04162 ENOG4105WH1 Two component transcriptional regulator luxr family DB29_04163 ENOG4108ZGX Histidine kinase DB29_04167 ENOG4105CJ1 ABC, transporter DB29_04169 ENOG4105C9U ATP-dependent DNA helicase RecQ DB29_04170 ENOG4108X3M OsmC Ohr family protein DB29_04173 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) DB29_04175 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 DB29_04176 ENOG4105C7S Dehydrogenase DB29_04178 ENOG4105C5H ABC transporter DB29_04180 ENOG4105C9U ATP-dependent DNA helicase RecQ DB29_04186 ENOG4107YEI lmbE family DB29_04190 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) DB29_04192 ENOG4105FDT acyl-CoA dehydrogenase DB29_04195 ENOG4108C33 Resolvase DB29_04198 ENOG4108IMY Transcriptional regulator DB29_04210 ENOG4108UUM single-stranded DNA-binding protein DB29_04218 ENOG4105C79 DNA protecting protein DprA DB29_04221 ENOG4108TFU terminase (Small subunit) DB29_04265 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) DB29_04269 ENOG4105CI1 PTS System DB29_04279 ENOG410901P UPF0249 protein DB29_04280 ENOG4105F8D glycoside hydrolase family 4 DB29_04281 ENOG4105FDP GntR family transcriptional regulator DB29_04285 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DB29_04289 ENOG4105FJR Lmbe family DB29_04290 ENOG4105CPK Glycosyl transferase (Group 1 DB29_04291 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate DB29_04293 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) DB29_04294 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) DB29_04295 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) DB29_04297 ENOG4105DVT helicase DB29_04298 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) DB29_04300 ENOG4105YAC DB29_04302 ENOG4105C5S asparaginyl-tRNA synthetase DB29_04304 ENOG4105CSM endonuclease III DB29_04305 ENOG410890F Dynamin family DB29_04307 ENOG4108RS6 transposase DB29_04308 ENOG4105BZ4 penicillin-binding protein DB29_04315 ENOG4105C7B Threonine dehydratase DB29_04316 ENOG4108Z0Z intracellular protease Pfpi family DB29_04317 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) DB29_04319 ENOG4108Y6J UPF0403 protein DB29_04324 ENOG410905X membrane-flanked domain protein DB29_04325 ENOG4105CKV Membrane DB29_04331 ENOG4105BZ8 glutamate synthase DB29_04335 ENOG4105Y38 Kinase-associated protein B DB29_04336 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DB29_04340 ENOG410667J hydrolase DB29_04343 ENOG4105FBA Phospholipase Carboxylesterase DB29_04349 ENOG4108I5C dEAD DEAH box helicase DB29_04350 ENOG4107X2U Inherit from COG: Exonuclease-like protein DB29_04353 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) DB29_04354 ENOG41081VK Ribonuclease DB29_04356 ENOG4108B31 Spore germination protein DB29_04360 ENOG4105CMG Carbohydrate kinase DB29_04366 ENOG4105CTD carboxy-peptidase DB29_04368 ENOG4105K6S Short-chain dehydrogenase reductase Sdr DB29_04369 ENOG4108IJ8 ABC transporter DB29_04371 ENOG4105K4P CoA-binding domain protein DB29_04372 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DB29_04376 ENOG4105SCY DNAK suppressor DB29_04377 ENOG4108REF Sporulation integral membrane protein ytvi DB29_04378 ENOG4105ER2 Ompa motb domain protein DB29_04379 ENOG4105E14 MotA TolQ exbB proton channel DB29_04380 ENOG4108JYZ YitT family DB29_04383 ENOG4105CZ9 Domain of unknown function (DU1801) DB29_0P0020 ENOG4105W5Q DNA repair protein (RadC