locus-tag	class	description
DB29_00001	COG1413	lyase activity
DB29_00004	COG0596	Alpha beta hydrolase
DB29_00007	COG1595	DNA-templated transcription, initiation
DB29_00009	COG1131	(ABC) transporter
DB29_00013	COG2814	Major facilitator Superfamily
DB29_00016	COG1695	Transcriptional regulator
DB29_00017	COG3708	Transcriptional regulator
DB29_00017	COG2207	Transcriptional regulator
DB29_00018	COG0733	neurotransmitter:sodium symporter activity
DB29_00020	COG2151	metal-sulfur cluster biosynthetic enzyme
DB29_00022	COG0697	spore germination
DB29_00024	COG0217	transcriptional regulatory protein
DB29_00026	COG0708	Exodeoxyribonuclease III
DB29_00027	COG3048	D-serine ammonia-lyase activity
DB29_00028	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DB29_00029	COG1082	Xylose isomerase domain protein TIM barrel
DB29_00031	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DB29_00035	COG2329	Antibiotic biosynthesis monooxygenase
DB29_00036	COG0626	cystathionine gamma-synthase activity
DB29_00037	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DB29_00038	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DB29_00041	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DB29_00042	COG1309	transcriptional regulator
DB29_00044	COG0791	NLP P60 protein
DB29_00044	COG1388	LysM domain
DB29_00046	COG2094	Belongs to the DNA glycosylase MPG family
DB29_00047	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DB29_00048	COG1122	ATPase activity
DB29_00051	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DB29_00053	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DB29_00054	COG3584	3D domain protein
DB29_00054	COG3583	domain protein
DB29_00055	COG1388	LysM domain
DB29_00055	COG3584	3D domain protein
DB29_00056	COG2226	methyltransferase
DB29_00057	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DB29_00059	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DB29_00062	COG2153	protein acetylation
DB29_00065	COG1690	Belongs to the RtcB family
DB29_00067	COG1803	Methylglyoxal synthase
DB29_00068	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DB29_00069	COG1694	Mazg nucleotide pyrophosphohydrolase
DB29_00070	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DB29_00071	COG2814	Major facilitator Superfamily
DB29_00072	COG2738	Putative neutral zinc metallopeptidase
DB29_00074	COG4347	Protein of unknown function (DUF1405)
DB29_00076	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DB29_00077	COG0723	plastoquinol--plastocyanin reductase activity
DB29_00079	COG5582	Belongs to the UPF0302 family
DB29_00080	COG0457	Tetratricopeptide repeat
DB29_00081	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DB29_00082	COG0287	Prephenate dehydrogenase
DB29_00083	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DB29_00084	COG0159	tryptophan synthase activity
DB29_00085	COG0133	tryptophan synthase activity
DB29_00086	COG0135	phosphoribosylanthranilate isomerase activity
DB29_00087	COG0134	indole-3-glycerol-phosphate synthase activity
DB29_00088	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DB29_00090	COG4401	Chorismate mutase type I
DB29_00091	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DB29_00092	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DB29_00093	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DB29_00095	COG0105	UTP biosynthetic process
DB29_00096	COG0142	geranyltranstransferase activity
DB29_00098	COG0109	protoheme IX farnesyltransferase activity
DB29_00099	COG2226	methyltransferase
DB29_00100	COG0142	geranyltranstransferase activity
DB29_00102	COG0302	gtp cyclohydrolase
DB29_00103	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DB29_00107	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DB29_00108	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DB29_00109	COG1160	GTP binding
DB29_00111	COG0539	negative regulation of cytoplasmic translation
DB29_00112	COG0204	Acyl-transferase
DB29_00113	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DB29_00114	COG2959	enzyme of heme biosynthesis
DB29_00115	COG3773	Cell wall hydrolase
DB29_00115	COG3409	Peptidoglycan-binding domain 1 protein
DB29_00116	COG0646	methionine synthase
DB29_00116	COG1410	methionine synthase
DB29_00117	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DB29_00117	COG0646	methionine synthase
DB29_00118	COG0626	cystathionine gamma-synthase activity
DB29_00120	COG2339	peptidase activity
DB29_00122	COG0492	ferredoxin-NADP+ reductase activity
DB29_00123	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DB29_00125	COG5002	protein histidine kinase activity
DB29_00126	COG0745	RESPONSE REGULATOR receiver
DB29_00127	COG4862	establishment of competence for transformation
DB29_00128	COG0789	Transcriptional regulator
DB29_00129	COG1408	metallophosphoesterase
DB29_00130	COG1473	amidohydrolase
DB29_00132	COG0438	transferase activity, transferring glycosyl groups
DB29_00133	COG0438	transferase activity, transferring glycosyl groups
DB29_00139	COG1266	CAAX protease self-immunity
DB29_00140	COG0514	ATP-dependent DNA helicase (RecQ)
DB29_00141	COG4955	Helix-turn-helix domain
DB29_00144	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DB29_00146	COG0446	pyridine nucleotide-disulphide oxidoreductase
DB29_00148	COG0861	Integral membrane protein TerC family
DB29_00151	COG1120	ATPase activity
DB29_00152	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DB29_00154	COG5002	protein histidine kinase activity
DB29_00155	COG0745	RESPONSE REGULATOR receiver
DB29_00156	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DB29_00157	COG1333	cytochrome c biogenesis protein
DB29_00158	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DB29_00159	COG1187	pseudouridine synthase activity
DB29_00160	COG0700	Nucleoside recognition
DB29_00161	COG2715	membrane protein required for spore maturation
DB29_00162	COG1686	Belongs to the peptidase S11 family
DB29_00164	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DB29_00167	COG2323	membrane
DB29_00170	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DB29_00171	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DB29_00172	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DB29_00173	COG1012	belongs to the aldehyde dehydrogenase family
DB29_00175	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DB29_00176	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DB29_00177	COG1547	Domain of unknown function (DUF309)
DB29_00178	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DB29_00179	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DB29_00179	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DB29_00180	COG0307	riboflavin synthase, alpha
DB29_00183	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DB29_00184	COG1012	belongs to the aldehyde dehydrogenase family
DB29_00185	COG2084	Dehydrogenase
DB29_00186	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DB29_00187	COG2079	MmgE PrpD family protein
DB29_00188	COG0372	Belongs to the citrate synthase family
DB29_00191	COG0583	DNA-binding transcription factor activity
DB29_00192	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DB29_00194	COG0019	diaminopimelate decarboxylase activity
DB29_00195	COG0697	spore germination
DB29_00198	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DB29_00201	COG2172	sigma factor antagonist activity
DB29_00203	COG1686	Belongs to the peptidase S11 family
DB29_00204	COG0726	polysaccharide deacetylase
DB29_00205	COG1988	membrane-bound metal-dependent
DB29_00208	COG2814	Major facilitator Superfamily
DB29_00210	COG1764	response to oxidative stress
DB29_00212	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DB29_00213	COG4974	Belongs to the 'phage' integrase family
DB29_00215	COG0735	belongs to the Fur family
DB29_00216	COG1300	Membrane
DB29_00217	COG0494	nUDIX hydrolase
DB29_00219	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DB29_00220	COG1968	undecaprenyl-diphosphatase activity
DB29_00221	COG1850	ribulose-bisphosphate carboxylase activity
DB29_00222	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
DB29_00223	COG2190	(PTS) system
DB29_00225	COG1510	regulation of RNA biosynthetic process
DB29_00229	COG0367	asparagine synthase
DB29_00230	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DB29_00231	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DB29_00232	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DB29_00234	COG0527	aspartate kinase activity
DB29_00237	COG0789	Transcriptional regulator
DB29_00238	COG2861	carbohydrate metabolic process
DB29_00242	COG0517	IMP dehydrogenase activity
DB29_00245	COG1728	Protein conserved in bacteria
DB29_00247	COG2195	Cleaves the N-terminal amino acid of tripeptides
DB29_00248	COG0346	lactoylglutathione lyase activity
DB29_00249	COG1376	ErfK ybiS ycfS ynhG family protein
DB29_00250	COG4129	membrane
DB29_00251	COG4191	Histidine kinase
DB29_00253	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DB29_00254	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DB29_00255	COG0114	fumarate hydratase activity
DB29_00256	COG1396	sequence-specific DNA binding
DB29_00257	COG1396	sequence-specific DNA binding
DB29_00259	COG2382	esterase
DB29_00260	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DB29_00261	COG2153	protein acetylation
DB29_00262	COG0011	TIGRFAM Protein of
DB29_00264	COG0351	phosphomethylpyrimidine kinase
DB29_00264	COG0352	thiamine-phosphate diphosphorylase activity
DB29_00265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DB29_00266	COG2022	thiamine diphosphate biosynthetic process
DB29_00268	COG0352	thiamine-phosphate diphosphorylase activity
DB29_00269	COG1027	Aspartate ammonia-lyase
DB29_00270	COG1940	carbohydrate kinase activity
DB29_00274	COG0697	spore germination
DB29_00275	COG0705	Rhomboid family
DB29_00275	COG0457	Tetratricopeptide repeat
DB29_00278	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DB29_00280	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DB29_00281	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DB29_00287	COG0477	Major facilitator Superfamily
DB29_00288	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DB29_00289	COG0704	Plays a role in the regulation of phosphate uptake
DB29_00292	COG4086	secreted protein
DB29_00293	COG2814	Major facilitator Superfamily
DB29_00295	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DB29_00296	COG4709	membrane
DB29_00297	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
DB29_00299	COG0735	belongs to the Fur family
DB29_00300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DB29_00301	COG1121	(ABC) transporter
DB29_00303	COG5002	protein histidine kinase activity
DB29_00305	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DB29_00306	COG0513	Belongs to the DEAD box helicase family
DB29_00308	COG1329	Transcriptional regulator
DB29_00309	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DB29_00310	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DB29_00311	COG2384	SAM-dependent methyltransferase
DB29_00312	COG2010	Cytochrome c
DB29_00313	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DB29_00314	COG0358	DNA primase activity
DB29_00315	COG1671	Belongs to the UPF0178 family
DB29_00317	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DB29_00318	COG0517	IMP dehydrogenase activity
DB29_00319	COG0751	glycine-tRNA ligase activity
DB29_00320	COG0752	glycyl-tRNA synthetase alpha subunit
DB29_00322	COG1381	Involved in DNA repair and RecF pathway recombination
DB29_00324	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DB29_00325	COG0295	cytidine deaminase activity
DB29_00326	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DB29_00327	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DB29_00328	COG1480	7TM receptor with intracellular HD hydrolase
DB29_00329	COG1702	phosphate starvation-inducible protein PhoH
DB29_00333	COG4864	UPF0365 protein
DB29_00334	COG1030	water channel activity
DB29_00335	COG1610	YqeY-like protein
DB29_00336	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DB29_00337	COG1283	sodium-dependent phosphate transmembrane transporter activity
DB29_00339	COG0667	Aldo Keto reductase
DB29_00340	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DB29_00342	COG1301	dicarboxylic acid transport
DB29_00343	COG2226	methyltransferase
DB29_00344	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DB29_00345	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DB29_00346	COG2264	protein methyltransferase activity
DB29_00347	COG0484	heat shock protein binding
DB29_00348	COG0443	Heat shock 70 kDa protein
DB29_00349	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DB29_00350	COG1420	regulation of RNA biosynthetic process
DB29_00351	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DB29_00352	COG0481	GTPase activity
DB29_00354	COG0860	N-Acetylmuramoyl-L-alanine amidase
DB29_00355	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DB29_00356	COG0268	Binds directly to 16S ribosomal RNA
DB29_00357	COG1466	dna polymerase III delta subunit
DB29_00359	COG0658	competence protein
DB29_00359	COG2333	competence protein COMEC
DB29_00360	COG2131	deaminase
DB29_00361	COG1555	photosystem II stabilization
DB29_00361	COG1596	polysaccharide export
DB29_00362	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DB29_00363	COG2226	methyltransferase
DB29_00364	COG2996	Protein conserved in bacteria
DB29_00365	COG0799	negative regulation of ribosome biogenesis
DB29_00366	COG1713	HD superfamily hydrolase involved in NAD metabolism
DB29_00367	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DB29_00368	COG1534	Rna-binding protein
DB29_00369	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DB29_00370	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DB29_00371	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DB29_00380	COG0776	regulation of translation
DB29_00383	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DB29_00384	COG2223	nitrite transmembrane transporter activity
DB29_00385	COG0243	molybdopterin cofactor binding
DB29_00386	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DB29_00387	COG2146	nitrite reductase [NAD(P)H] activity
DB29_00388	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DB29_00389	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DB29_00389	COG1587	Uroporphyrinogen-III synthase
DB29_00390	COG1943	Transposase
DB29_00394	COG1191	sigma factor activity
DB29_00395	COG0385	Bile acid
DB29_00397	COG1288	antiporter activity
DB29_00398	COG0095	Lipoate-protein ligase
DB29_00400	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DB29_00401	COG0366	Alpha amylase catalytic
DB29_00405	COG1309	transcriptional regulator
DB29_00406	COG0601	transmembrane transport
DB29_00407	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DB29_00408	COG0444	Belongs to the ABC transporter superfamily
DB29_00409	COG4608	Belongs to the ABC transporter superfamily
DB29_00410	COG0747	negative chemotaxis
DB29_00413	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DB29_00414	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DB29_00415	COG3285	dna ligase
DB29_00415	COG1793	dna ligase
DB29_00417	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DB29_00418	COG0572	uridine kinase
DB29_00420	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DB29_00421	COG3906	Belongs to the UPF0473 family
DB29_00422	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DB29_00423	COG4472	Bacterial protein of unknown function (DUF965)
DB29_00424	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DB29_00426	COG0628	permease
DB29_00429	COG3881	PFAM PRC-barrel domain
DB29_00430	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DB29_00432	COG0482	sulfurtransferase activity
DB29_00433	COG1104	cysteine desulfurase activity
DB29_00434	COG1959	2 iron, 2 sulfur cluster binding
DB29_00435	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DB29_00437	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DB29_00438	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DB29_00440	COG0460	homoserine dehydrogenase
DB29_00441	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DB29_00442	COG0124	histidyl-tRNA synthetase
DB29_00444	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DB29_00445	COG0673	inositol 2-dehydrogenase activity
DB29_00447	COG1609	Transcriptional regulator
DB29_00448	COG1490	D-aminoacyl-tRNA deacylase activity
DB29_00449	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DB29_00450	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DB29_00451	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DB29_00451	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DB29_00452	COG5416	Lipopolysaccharide assembly protein A domain
DB29_00453	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DB29_00453	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DB29_00454	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DB29_00454	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DB29_00456	COG2244	polysaccharide biosynthetic process
DB29_00460	COG1862	Preprotein translocase
DB29_00461	COG0343	queuine tRNA-ribosyltransferase activity
DB29_00462	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DB29_00464	COG2255	four-way junction helicase activity
DB29_00465	COG0632	four-way junction helicase activity
DB29_00469	COG1388	LysM domain
DB29_00470	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DB29_00471	COG0157	Belongs to the NadC ModD family
DB29_00472	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DB29_00473	COG1104	cysteine desulfurase activity
DB29_00475	COG1827	regulation of RNA biosynthetic process
DB29_00476	COG0077	Prephenate dehydratase
DB29_00477	COG4492	Belongs to the UPF0735 family
DB29_00478	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DB29_00479	COG3290	protein histidine kinase activity
DB29_00484	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DB29_00485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DB29_00486	COG0785	Cytochrome C biogenesis protein
DB29_00488	COG4473	ABC transporter
DB29_00489	COG1131	(ABC) transporter
DB29_00490	COG0537	adenosine 5'-monophosphoramidase activity
DB29_00491	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DB29_00493	COG1846	Transcriptional regulator
DB29_00498	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DB29_00500	COG3481	metal-dependent phosphohydrolase, HD sub domain
DB29_00501	COG2205	protein histidine kinase activity
DB29_00501	COG2770	Histidine kinase
DB29_00502	COG0745	RESPONSE REGULATOR receiver
DB29_00505	COG0561	phosphatase activity
DB29_00506	COG3679	Belongs to the UPF0342 family
DB29_00507	COG4399	Belongs to the UPF0754 family
DB29_00510	COG2508	Transcriptional regulator
DB29_00511	COG3842	ATPase activity
DB29_00515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DB29_00516	COG1024	Enoyl-CoA hydratase
DB29_00517	COG0511	ligase activity, forming carbon-carbon bonds
DB29_00518	COG0439	Biotin carboxylase
DB29_00519	COG1960	acyl-CoA dehydrogenase activity
DB29_00520	COG1704	LemA family
DB29_00522	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DB29_00523	COG1132	(ABC) transporter
DB29_00524	COG1132	(ABC) transporter
DB29_00525	COG2719	SpoVR family
DB29_00526	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DB29_00527	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DB29_00528	COG1489	DNA binding
DB29_00529	COG3153	acetyltransferase
DB29_00529	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DB29_00532	COG0584	glycerophosphoryl diester phosphodiesterase
DB29_00533	COG0179	Fumarylacetoacetate (FAA) hydrolase
DB29_00534	COG0436	Aminotransferase
DB29_00537	COG0363	glucosamine-6-phosphate deaminase activity
DB29_00538	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DB29_00540	COG0165	Argininosuccinate lyase
DB29_00541	COG2188	Transcriptional regulator
DB29_00543	COG1028	Short-chain dehydrogenase reductase Sdr
DB29_00550	COG2814	Major facilitator Superfamily
DB29_00554	COG2718	Belongs to the UPF0229 family
DB29_00557	COG2766	serine protein kinase
DB29_00558	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DB29_00562	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DB29_00566	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DB29_00569	COG0783	Belongs to the Dps family
DB29_00570	COG1363	Peptidase, m42
DB29_00572	COG1131	(ABC) transporter
DB29_00573	COG1725	Transcriptional regulator
DB29_00575	COG1131	(ABC) transporter
DB29_00577	COG2207	Transcriptional regulator
DB29_00577	COG1917	Cupin 2, conserved barrel domain protein
DB29_00578	COG1621	beta-fructofuranosidase activity
DB29_00580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DB29_00580	COG1263	PTS System
DB29_00582	COG1012	belongs to the aldehyde dehydrogenase family
DB29_00584	COG1966	Carbon starvation protein
DB29_00586	COG0471	metal ion transport
DB29_00587	COG1405	negative regulation of cell septum assembly
DB29_00587	COG3012	SEC-C Motif Domain Protein
DB29_00589	COG0737	Belongs to the 5'-nucleotidase family
DB29_00591	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DB29_00595	COG0584	glycerophosphoryl diester phosphodiesterase
DB29_00597	COG4894	glucomannan catabolic process
DB29_00598	COG1442	glycosyl transferase family 8
DB29_00601	COG1131	(ABC) transporter
DB29_00602	COG2197	response regulator
DB29_00603	COG4585	Histidine kinase
DB29_00608	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DB29_00609	COG1733	regulation of RNA biosynthetic process
DB29_00613	COG2267	carboxylic ester hydrolase activity
DB29_00628	COG3964	amidohydrolase
DB29_00638	COG1733	regulation of RNA biosynthetic process
DB29_00639	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DB29_00640	COG0789	Transcriptional regulator
DB29_00643	COG2814	Major facilitator Superfamily
DB29_00644	COG1959	2 iron, 2 sulfur cluster binding
DB29_00646	COG0446	pyridine nucleotide-disulphide oxidoreductase
DB29_00648	COG0596	Alpha beta hydrolase
DB29_00650	COG1846	Transcriptional regulator
DB29_00652	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DB29_00653	COG2814	Major facilitator Superfamily
DB29_00654	COG0640	Transcriptional regulator
DB29_00657	COG5434	Belongs to the glycosyl hydrolase 28 family
DB29_00660	COG0735	belongs to the Fur family
DB29_00662	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DB29_00663	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DB29_00664	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DB29_00665	COG4129	membrane
DB29_00666	COG1132	(ABC) transporter
DB29_00667	COG3557	Belongs to the UPF0374 family
DB29_00669	COG1028	Short-chain dehydrogenase reductase Sdr
DB29_00672	COG1028	Short-chain dehydrogenase reductase Sdr
DB29_00674	COG1988	membrane-bound metal-dependent
DB29_00678	COG2137	regulation of response to DNA damage stimulus
DB29_00679	COG1090	epimerase
DB29_00681	COG1619	proteins homologs of microcin C7 resistance protein MccF
DB29_00682	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DB29_00686	COG0445	tRNA wobble uridine modification
DB29_00687	COG0726	polysaccharide deacetylase
DB29_00689	COG1253	flavin adenine dinucleotide binding
DB29_00690	COG0588	phosphoglycerate mutase activity
DB29_00691	COG0535	radical SAM domain protein
DB29_00696	COG1271	oxidase subunit
DB29_00697	COG1294	oxidase, subunit
DB29_00699	COG1164	Oligoendopeptidase f
DB29_00701	COG0753	catalase activity
DB29_00703	COG1012	belongs to the aldehyde dehydrogenase family
DB29_00704	COG3341	Caulimovirus viroplasmin
DB29_00704	COG0328	RNA-DNA hybrid ribonuclease activity
DB29_00707	COG2002	toxin-antitoxin pair type II binding
DB29_00709	COG0733	neurotransmitter:sodium symporter activity
DB29_00711	COG1077	Cell shape determining protein MreB Mrl
DB29_00712	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DB29_00712	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DB29_00712	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DB29_00713	COG1105	Belongs to the carbohydrate kinase PfkB family
DB29_00714	COG1349	DNA-binding transcription factor activity
DB29_00715	COG0488	(ABC) transporter
DB29_00716	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
DB29_00718	COG2188	Transcriptional regulator
DB29_00719	COG0366	Alpha amylase catalytic
DB29_00720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DB29_00720	COG1263	PTS System
DB29_00722	COG1649	PFAM Uncharacterised BCR, COG1649
DB29_00723	COG2244	polysaccharide biosynthetic process
DB29_00724	COG1115	amino acid carrier protein
DB29_00725	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DB29_00726	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DB29_00729	COG1132	(ABC) transporter
DB29_00730	COG1132	(ABC) transporter
DB29_00731	COG3973	AAA domain
DB29_00734	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DB29_00735	COG3639	organic phosphonate transmembrane transporter activity
DB29_00736	COG3639	organic phosphonate transmembrane transporter activity
DB29_00737	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DB29_00744	COG0747	negative chemotaxis
DB29_00745	COG4608	Belongs to the ABC transporter superfamily
DB29_00746	COG0444	Belongs to the ABC transporter superfamily
DB29_00749	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DB29_00750	COG2391	methyltransferase activity
DB29_00752	COG4120	Belongs to the binding-protein-dependent transport system permease family
DB29_00753	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DB29_00756	COG4208	sulfate ABC transporter
DB29_00758	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DB29_00760	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DB29_00761	COG5002	protein histidine kinase activity
DB29_00762	COG0277	FAD linked oxidase domain protein
DB29_00763	COG0385	Bile acid
DB29_00764	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DB29_00766	COG0747	negative chemotaxis
DB29_00768	COG1396	sequence-specific DNA binding
DB29_00771	COG0395	ABC-type sugar transport system, permease component
DB29_00772	COG1175	transmembrane transport
DB29_00782	COG1522	sequence-specific DNA binding
DB29_00783	COG1279	arginine transmembrane transporter activity
DB29_00784	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DB29_00785	COG2318	DinB family
DB29_00786	COG3011	Protein conserved in bacteria
DB29_00805	COG3546	catalase activity
DB29_00806	COG1280	lysine exporter protein (LysE YggA)
DB29_00807	COG1113	amino acid transport
DB29_00808	COG5577	PFAM Coat F domain
DB29_00810	COG2423	ornithine cyclodeaminase activity
DB29_00811	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DB29_00814	COG0010	Belongs to the arginase family
DB29_00816	COG0745	RESPONSE REGULATOR receiver
DB29_00818	COG1686	Belongs to the peptidase S11 family
DB29_00819	COG0640	Transcriptional regulator
DB29_00820	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DB29_00822	COG1131	(ABC) transporter
DB29_00823	COG2205	protein histidine kinase activity
DB29_00824	COG0745	RESPONSE REGULATOR receiver
DB29_00826	COG3764	Sortase (surface protein transpeptidase)
DB29_00828	COG3397	chitin binding
DB29_00829	COG1028	Short-chain dehydrogenase reductase Sdr
DB29_00831	COG3732	PTS system glucitol sorbitol-specific
DB29_00836	COG0246	Mannitol dehydrogenase
DB29_00837	COG2721	sulfolactate sulfo-lyase activity
DB29_00838	COG0673	inositol 2-dehydrogenase activity
DB29_00839	COG5578	integral membrane protein
DB29_00841	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DB29_00844	COG0395	ABC-type sugar transport system, permease component
DB29_00845	COG4209	transmembrane transport
DB29_00846	COG1653	transport
DB29_00848	COG2207	Transcriptional regulator
DB29_00849	COG1917	Cupin 2, conserved barrel domain protein
DB29_00849	COG2169	Transcriptional regulator
DB29_00850	COG5297	Belongs to the glycosyl hydrolase family 6
DB29_00850	COG3250	beta-galactosidase activity
DB29_00853	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DB29_00856	COG0395	ABC-type sugar transport system, permease component
DB29_00857	COG4209	transmembrane transport
DB29_00858	COG2207	Transcriptional regulator
DB29_00858	COG4753	response regulator
DB29_00859	COG2972	Histidine kinase
DB29_00860	COG1501	Belongs to the glycosyl hydrolase 31 family
DB29_00863	COG1940	carbohydrate kinase activity
DB29_00863	COG1846	Transcriptional regulator
DB29_00864	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DB29_00865	COG2721	sulfolactate sulfo-lyase activity
DB29_00867	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DB29_00870	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DB29_00871	COG2207	Transcriptional regulator
DB29_00872	COG0179	Fumarylacetoacetate (FAA) hydrolase
DB29_00873	COG3340	Belongs to the peptidase S51 family
DB29_00876	COG0523	cobalamin synthesis protein
DB29_00877	COG3443	Belongs to the bacterial solute-binding protein 9 family
DB29_00878	COG3443	Belongs to the bacterial solute-binding protein 9 family
DB29_00878	COG0803	Belongs to the bacterial solute-binding protein 9 family
DB29_00879	COG1121	(ABC) transporter
DB29_00880	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DB29_00881	COG1012	belongs to the aldehyde dehydrogenase family
DB29_00882	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DB29_00884	COG1414	Transcriptional regulator
DB29_00886	COG0129	dihydroxy-acid dehydratase activity
DB29_00896	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DB29_00897	COG0716	FMN binding
DB29_00899	COG1597	lipid kinase activity
DB29_00900	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DB29_00901	COG0154	amidase activity
DB29_00902	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DB29_00903	COG2318	DinB family
DB29_00910	COG4851	CamS sex pheromone cAM373 precursor
DB29_00911	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DB29_00912	COG0210	DNA helicase
DB29_00913	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
DB29_00915	COG1120	ATPase activity
DB29_00916	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DB29_00917	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DB29_00922	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DB29_00923	COG4496	protein, YerC YecD
DB29_00924	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DB29_00926	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DB29_00930	COG1510	regulation of RNA biosynthetic process
DB29_00940	COG1131	(ABC) transporter
DB29_00941	COG2197	response regulator
DB29_00942	COG4585	Histidine kinase
DB29_00945	COG1028	Short-chain dehydrogenase reductase Sdr
DB29_00947	COG1063	alcohol dehydrogenase
DB29_00948	COG1028	Short-chain dehydrogenase reductase Sdr
DB29_00949	COG1609	Transcriptional regulator
DB29_00952	COG0151	Belongs to the GarS family
DB29_00953	COG0138	bifunctional purine biosynthesis protein purh
DB29_00954	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DB29_00955	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DB29_00956	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DB29_00957	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DB29_00958	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DB29_00959	COG0047	phosphoribosylformylglycinamidine synthase activity
DB29_00960	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DB29_00961	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DB29_00962	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DB29_00963	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DB29_00964	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DB29_00975	COG4565	transcriptional regulatory protein
DB29_00976	COG3290	protein histidine kinase activity
DB29_00977	COG0025	NhaP-type Na H and K H
DB29_00978	COG1132	(ABC) transporter
DB29_00979	COG1132	(ABC) transporter
DB29_00986	COG1755	Isoprenylcysteine carboxyl methyltransferase
DB29_00987	COG3424	synthase
DB29_00988	COG0789	Transcriptional regulator
DB29_00989	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DB29_00990	COG1904	glucuronate isomerase
DB29_00991	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
DB29_00992	COG1028	Short-chain dehydrogenase reductase Sdr
DB29_00993	COG1349	DNA-binding transcription factor activity
DB29_00994	COG2059	Chromate
DB29_00995	COG2059	Chromate
DB29_00996	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DB29_00997	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DB29_01000	COG3764	Sortase (surface protein transpeptidase)
DB29_01004	COG1510	regulation of RNA biosynthetic process
DB29_01006	COG1454	alcohol dehydrogenase
DB29_01007	COG2186	Transcriptional regulator
DB29_01008	COG1556	Lactate utilization protein
DB29_01009	COG1139	Iron-sulfur cluster binding protein
DB29_01010	COG0247	lactate metabolic process
DB29_01011	COG1620	l-lactate permease
DB29_01013	COG2124	cytochrome p450
DB29_01014	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DB29_01015	COG0326	Molecular chaperone. Has ATPase activity
DB29_01016	COG1335	isochorismatase
DB29_01018	COG1476	TRANSCRIPTIONal
DB29_01019	COG0737	Belongs to the 5'-nucleotidase family
DB29_01021	COG1012	belongs to the aldehyde dehydrogenase family
DB29_01022	COG3829	transcription factor binding
DB29_01022	COG3290	protein histidine kinase activity
DB29_01024	COG1408	metallophosphoesterase
DB29_01028	COG2252	PERMEase
DB29_01034	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
DB29_01035	COG1461	Dihydroxyacetone kinase
DB29_01036	COG2376	Dihydroxyacetone kinase
DB29_01038	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DB29_01041	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DB29_01042	COG0572	uridine kinase
DB29_01043	COG0789	Transcriptional regulator
DB29_01044	COG4221	oxidoreductase activity
DB29_01045	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DB29_01047	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DB29_01048	COG0577	efflux transmembrane transporter activity
DB29_01049	COG1136	(ABC) transporter
DB29_01051	COG2312	Erythromycin esterase
DB29_01059	COG0519	Catalyzes the synthesis of GMP from XMP
DB29_01059	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DB29_01060	COG1305	Transglutaminase-like
DB29_01061	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
DB29_01062	COG0714	Associated with various cellular activities
DB29_01064	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DB29_01067	COG0768	penicillin binding
DB29_01068	COG0778	Nitroreductase
DB29_01070	COG4824	toxin secretion phage lysis holin
DB29_01079	COG0281	malic enzyme
DB29_01080	COG3493	citrate carrier protein
DB29_01081	COG4565	transcriptional regulatory protein
DB29_01082	COG3290	protein histidine kinase activity
DB29_01083	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DB29_01084	COG1126	abc transporter atp-binding protein
DB29_01085	COG0765	amino acid transport
DB29_01086	COG0765	amino acid transport
DB29_01091	COG0463	Glycosyl transferase, family 2
DB29_01093	COG4485	Bacterial membrane protein, YfhO
DB29_01098	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DB29_01100	COG3383	formate dehydrogenase (NAD+) activity
DB29_01101	COG2116	formate transmembrane transporter activity
DB29_01102	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DB29_01103	COG0314	molybdopterin synthase activity
DB29_01104	COG1763	Mo-molybdopterin cofactor biosynthetic process
DB29_01105	COG0303	'Molybdopterin
DB29_01106	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DB29_01108	COG0746	molybdenum cofactor guanylyltransferase activity
DB29_01109	COG0315	cyclic pyranopterin monophosphate synthase activity
DB29_01110	COG2368	4-hydroxyphenylacetate
DB29_01111	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DB29_01112	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DB29_01113	COG4821	SIS domain
DB29_01118	COG0459	protein refolding
DB29_01119	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DB29_01120	COG1266	CAAX protease self-immunity
DB29_01122	COG0371	Dehydrogenase
DB29_01123	COG1464	Belongs to the NlpA lipoprotein family
DB29_01124	COG2011	ABC-type metal ion transport system permease component
DB29_01125	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DB29_01127	COG0805	protein transport
DB29_01128	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DB29_01129	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DB29_01130	COG0488	(ABC) transporter
DB29_01131	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DB29_01132	COG0456	acetyltransferase
DB29_01133	COG1214	PFAM Peptidase M22, glycoprotease
DB29_01134	COG0802	atpase or kinase
DB29_01135	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DB29_01138	COG0626	cystathionine gamma-synthase activity
DB29_01139	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DB29_01140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DB29_01141	COG1285	pathogenesis
DB29_01149	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DB29_01149	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DB29_01149	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DB29_01151	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DB29_01151	COG3711	transcriptional antiterminator
DB29_01156	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DB29_01157	COG1687	branched-chain amino acid
DB29_01158	COG5646	InterPro IPR014922
DB29_01166	COG0473	3-isopropylmalate dehydrogenase activity
DB29_01168	COG2514	catechol 2,3-dioxygenase activity
DB29_01169	COG2140	Oxalate decarboxylase
DB29_01171	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DB29_01172	COG0640	Transcriptional regulator
DB29_01173	COG1329	Transcriptional regulator
DB29_01174	COG1278	Cold shock
DB29_01177	COG0662	Cupin 2, conserved barrel domain protein
DB29_01179	COG2226	methyltransferase
DB29_01180	COG2409	Drug exporters of the RND superfamily
DB29_01182	COG3091	SprT-like family
DB29_01184	COG2183	response to ionizing radiation
DB29_01186	COG1191	sigma factor activity
DB29_01187	COG2172	sigma factor antagonist activity
DB29_01188	COG1366	Belongs to the anti-sigma-factor antagonist family
DB29_01189	COG2208	phosphoserine phosphatase activity
DB29_01190	COG2172	sigma factor antagonist activity
DB29_01191	COG1366	Belongs to the anti-sigma-factor antagonist family
DB29_01192	COG1366	Belongs to the anti-sigma-factor antagonist family
DB29_01193	COG2337	Toxic component of a toxin-antitoxin (TA) module
DB29_01194	COG0864	Transcriptional regulator
DB29_01195	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DB29_01196	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DB29_01197	COG0736	holo-[acyl-carrier-protein] synthase activity
DB29_01198	COG0705	Rhomboid family
DB29_01200	COG1368	sulfuric ester hydrolase activity
DB29_01202	COG1876	peptidase activity
DB29_01204	COG5578	integral membrane protein
DB29_01205	COG3214	Protein conserved in bacteria
DB29_01207	COG0673	inositol 2-dehydrogenase activity
DB29_01208	COG1082	Xylose isomerase domain protein TIM barrel
DB29_01211	COG1320	monovalent cation:proton antiporter activity
DB29_01212	COG2212	antiporter activity
DB29_01213	COG1863	multisubunit Na H antiporter MnhE subunit
DB29_01214	COG0651	ATP synthesis coupled electron transport
DB29_01215	COG1006	Multisubunit Na H antiporter MnhC subunit
DB29_01216	COG2111	Na H antiporter
DB29_01217	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DB29_01217	COG2111	Na H antiporter
DB29_01218	COG2205	protein histidine kinase activity
DB29_01220	COG1733	regulation of RNA biosynthetic process
DB29_01221	COG4608	Belongs to the ABC transporter superfamily
DB29_01222	COG0791	NLP P60 protein
DB29_01223	COG1619	proteins homologs of microcin C7 resistance protein MccF
DB29_01224	COG4166	transmembrane transport
DB29_01225	COG0444	Belongs to the ABC transporter superfamily
DB29_01226	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DB29_01227	COG0601	transmembrane transport
DB29_01228	COG2362	D-Aminopeptidase
DB29_01229	COG4191	Histidine kinase
DB29_01230	COG0784	Response regulator, receiver
DB29_01231	COG0765	amino acid transport
DB29_01232	COG0765	amino acid transport
DB29_01233	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DB29_01235	COG2962	Rard protein
DB29_01236	COG2706	6-phosphogluconolactonase activity
DB29_01237	COG0686	Belongs to the AlaDH PNT family
DB29_01238	COG2508	Transcriptional regulator
DB29_01238	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DB29_01240	COG0531	amino acid
DB29_01241	COG1876	peptidase activity
DB29_01243	COG1404	Belongs to the peptidase S8 family
DB29_01245	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DB29_01246	COG0596	Alpha beta hydrolase
DB29_01247	COG0861	Integral membrane protein TerC family
DB29_01249	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DB29_01250	COG2818	Glycosylase
DB29_01253	COG1404	Belongs to the peptidase S8 family
DB29_01254	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DB29_01256	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DB29_01259	COG3835	regulator
DB29_01260	COG1929	Belongs to the glycerate kinase type-1 family
DB29_01265	COG0024	Methionine aminopeptidase
DB29_01266	COG0456	acetyltransferase
DB29_01267	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DB29_01270	COG1846	Transcriptional regulator
DB29_01272	COG2239	Acts as a magnesium transporter
DB29_01273	COG2197	response regulator
DB29_01274	COG4585	Histidine kinase
DB29_01275	COG3239	Fatty acid desaturase
DB29_01276	COG2207	Transcriptional regulator
DB29_01277	COG1486	melibiose metabolic process
DB29_01278	COG0586	Pfam SNARE associated Golgi protein
DB29_01279	COG1191	sigma factor activity
DB29_01281	COG0395	ABC-type sugar transport system, permease component
DB29_01282	COG4209	transmembrane transport
DB29_01283	COG4753	response regulator
DB29_01283	COG2207	Transcriptional regulator
DB29_01284	COG2972	Histidine kinase
DB29_01287	COG2223	nitrite transmembrane transporter activity
DB29_01288	COG2197	response regulator
DB29_01291	COG2181	nitrate reductase activity
DB29_01293	COG1140	nitrate reductase beta subunit
DB29_01294	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DB29_01296	COG2195	Cleaves the N-terminal amino acid of tripeptides
DB29_01297	COG1263	PTS System
DB29_01297	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DB29_01297	COG2190	(PTS) system
DB29_01298	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
DB29_01299	COG1737	Transcriptional regulator
DB29_01304	COG1136	(ABC) transporter
DB29_01331	COG1511	domain protein
DB29_01332	COG1674	ftsk spoiiie
DB29_01333	COG4499	WXG100 protein secretion system (Wss), protein YukC
DB29_01335	COG4842	Belongs to the WXG100 family
DB29_01336	COG0395	ABC-type sugar transport system, permease component
DB29_01337	COG1175	transmembrane transport
DB29_01340	COG1119	ATPase activity
DB29_01341	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DB29_01342	COG1028	Short-chain dehydrogenase reductase Sdr
DB29_01343	COG0443	Heat shock 70 kDa protein
DB29_01344	COG2214	Heat shock protein DnaJ domain protein
DB29_01345	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DB29_01346	COG3457	Alanine racemase
DB29_01347	COG0626	cystathionine gamma-synthase activity
DB29_01348	COG1735	metal-dependent hydrolase with the TIM-barrel fold
DB29_01354	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DB29_01355	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DB29_01356	COG3290	protein histidine kinase activity
DB29_01357	COG4565	transcriptional regulatory protein
DB29_01358	COG2851	Citrate transporter
DB29_01363	COG2610	gluconate transmembrane transporter activity
DB29_01364	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DB29_01365	COG3395	kinase activity
DB29_01366	COG1349	DNA-binding transcription factor activity
DB29_01367	COG0697	spore germination
DB29_01374	COG3844	kynureninase activity
DB29_01375	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DB29_01377	COG2271	Major facilitator Superfamily
DB29_01378	COG5294	Protein conserved in bacteria
DB29_01384	COG3394	polysaccharide catabolic process
DB29_01385	COG1486	melibiose metabolic process
DB29_01386	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DB29_01387	COG1447	Phosphotransferase system cellobiose-specific component IIA
DB29_01388	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DB29_01389	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DB29_01391	COG0798	PFAM Bile acid sodium symporter
DB29_01392	COG2814	Major facilitator Superfamily
DB29_01395	COG0163	prenyltransferase activity
DB29_01396	COG1028	Short-chain dehydrogenase reductase Sdr
DB29_01397	COG1312	Catalyzes the dehydration of D-mannonate
DB29_01398	COG1063	alcohol dehydrogenase
DB29_01399	COG1053	succinate dehydrogenase
DB29_01400	COG0473	3-isopropylmalate dehydrogenase activity
DB29_01401	COG0583	DNA-binding transcription factor activity
DB29_01406	COG2188	Transcriptional regulator
DB29_01407	COG1131	(ABC) transporter
DB29_01409	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DB29_01410	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DB29_01413	COG1587	Uroporphyrinogen-III synthase
DB29_01413	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DB29_01414	COG0529	Catalyzes the synthesis of activated sulfate
DB29_01415	COG0306	phosphate transporter
DB29_01416	COG2046	Belongs to the sulfate adenylyltransferase family
DB29_01417	COG0175	sulfate reduction
DB29_01419	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DB29_01423	COG1802	Transcriptional regulator
DB29_01426	COG1116	anion transmembrane transporter activity
DB29_01427	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DB29_01428	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DB29_01429	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DB29_01430	COG0431	NADPH-dependent FMN reductase
DB29_01431	COG5583	Uncharacterized small protein (DUF2292)
DB29_01433	COG2258	MOSC domain
DB29_01438	COG0318	PFAM AMP-dependent synthetase and ligase
DB29_01443	COG1942	4-Oxalocrotonate Tautomerase
DB29_01444	COG0477	Major facilitator Superfamily
DB29_01446	COG4126	flavin adenine dinucleotide binding
DB29_01451	COG2508	Transcriptional regulator
DB29_01452	COG0673	inositol 2-dehydrogenase activity
DB29_01454	COG1940	carbohydrate kinase activity
DB29_01456	COG1070	Carbohydrate kinase
DB29_01457	COG2115	Belongs to the xylose isomerase family
DB29_01458	COG1414	Transcriptional regulator
DB29_01459	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DB29_01461	COG4608	Belongs to the ABC transporter superfamily
DB29_01462	COG0444	Belongs to the ABC transporter superfamily
DB29_01465	COG0747	negative chemotaxis
DB29_01466	COG1228	amidohydrolase
DB29_01467	COG1228	amidohydrolase
DB29_01472	COG0395	ABC-type sugar transport system, permease component
DB29_01473	COG4209	transmembrane transport
DB29_01475	COG3507	Belongs to the glycosyl hydrolase 43 family
DB29_01476	COG2207	Transcriptional regulator
DB29_01476	COG0662	Cupin 2, conserved barrel domain protein
DB29_01478	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DB29_01479	COG2011	ABC-type metal ion transport system permease component
DB29_01480	COG1464	Belongs to the NlpA lipoprotein family
DB29_01481	COG1473	amidohydrolase
DB29_01483	COG2084	Dehydrogenase
DB29_01484	COG2610	gluconate transmembrane transporter activity
DB29_01485	COG1737	Transcriptional regulator
DB29_01488	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DB29_01489	COG2186	Transcriptional regulator
DB29_01490	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DB29_01492	COG4145	pantothenate transmembrane transporter activity
DB29_01500	COG0710	3-dehydroquinate dehydratase activity
DB29_01503	COG0655	NAD(P)H dehydrogenase (quinone) activity
DB29_01505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DB29_01508	COG0745	RESPONSE REGULATOR receiver
DB29_01509	COG2205	protein histidine kinase activity
DB29_01514	COG4948	Mandelate Racemase Muconate Lactonizing
DB29_01516	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DB29_01519	COG2755	lipolytic protein G-D-S-L family
DB29_01520	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DB29_01529	COG0438	transferase activity, transferring glycosyl groups
DB29_01532	COG0438	transferase activity, transferring glycosyl groups
DB29_01538	COG2226	methyltransferase
DB29_01540	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DB29_01541	COG0535	radical SAM domain protein
DB29_01547	COG3212	peptidase
DB29_01548	COG3212	peptidase
DB29_01549	COG3850	Histidine kinase
DB29_01549	COG5002	protein histidine kinase activity
DB29_01550	COG0745	RESPONSE REGULATOR receiver
DB29_01551	COG4821	SIS domain
DB29_01552	COG2188	Transcriptional regulator
DB29_01554	COG1388	LysM domain
DB29_01554	COG3584	3D domain protein
DB29_01559	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DB29_01559	COG3711	transcriptional antiterminator
DB29_01560	COG2723	6-phospho-beta-galactosidase activity
DB29_01561	COG1447	Phosphotransferase system cellobiose-specific component IIA
DB29_01562	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DB29_01563	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DB29_01564	COG1357	PFAM Pentapeptide repeats (8 copies)
DB29_01568	COG2807	transmembrane transport
DB29_01570	COG2186	Transcriptional regulator
DB29_01571	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DB29_01572	COG1012	belongs to the aldehyde dehydrogenase family
DB29_01576	COG1312	Catalyzes the dehydration of D-mannonate
DB29_01586	COG0840	transmembrane signaling receptor activity
DB29_01588	COG2851	Citrate transporter
DB29_01591	COG3829	transcription factor binding
DB29_01591	COG3290	protein histidine kinase activity
DB29_01592	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DB29_01593	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DB29_01594	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DB29_01597	COG1917	Cupin 2, conserved barrel domain protein
DB29_01598	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DB29_01598	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DB29_01599	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DB29_01600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DB29_01600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DB29_01600	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DB29_01601	COG0191	fructose-bisphosphate aldolase activity
DB29_01602	COG3711	transcriptional antiterminator
DB29_01603	COG0246	Mannitol dehydrogenase
DB29_01604	COG2721	sulfolactate sulfo-lyase activity
DB29_01605	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DB29_01607	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DB29_01609	COG1063	alcohol dehydrogenase
DB29_01611	COG1653	transport
DB29_01612	COG1175	transmembrane transport
DB29_01617	COG2323	membrane
DB29_01618	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DB29_01619	COG0673	inositol 2-dehydrogenase activity
DB29_01620	COG0191	fructose-bisphosphate aldolase activity
DB29_01621	COG0673	inositol 2-dehydrogenase activity
DB29_01622	COG1082	Xylose isomerase domain protein TIM barrel
DB29_01623	COG3962	Belongs to the TPP enzyme family
DB29_01624	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DB29_01625	COG3718	enzyme involved in inositol metabolism
DB29_01626	COG1012	belongs to the aldehyde dehydrogenase family
DB29_01627	COG1349	DNA-binding transcription factor activity
DB29_01628	COG2814	Major facilitator Superfamily
DB29_01630	COG1309	transcriptional regulator
DB29_01631	COG2076	Multidrug Resistance protein
DB29_01632	COG2076	Multidrug Resistance protein
DB29_01633	COG3279	Response regulator of the LytR AlgR family
DB29_01639	COG1131	(ABC) transporter
DB29_01640	COG1486	melibiose metabolic process
DB29_01641	COG4214	carbohydrate transport
DB29_01642	COG1129	ABC transporter
DB29_01643	COG4213	ABC transporter substrate-binding protein
DB29_01645	COG2160	L-arabinose isomerase activity
DB29_01646	COG1069	ribulokinase activity
DB29_01648	COG0371	Dehydrogenase
DB29_01649	COG0647	UMP catabolic process
DB29_01650	COG2207	Transcriptional regulator
DB29_01652	COG5578	integral membrane protein
DB29_01653	COG0395	ABC-type sugar transport system, permease component
DB29_01654	COG1175	transmembrane transport
DB29_01657	COG0395	ABC-type sugar transport system, permease component
DB29_01658	COG1175	transmembrane transport
DB29_01660	COG3401	FG-GAP repeat protein
DB29_01663	COG0745	RESPONSE REGULATOR receiver
DB29_01664	COG5002	protein histidine kinase activity
DB29_01666	COG0395	ABC-type sugar transport system, permease component
DB29_01667	COG1175	transmembrane transport
DB29_01668	COG1653	transport
DB29_01669	COG4753	response regulator
DB29_01669	COG2207	Transcriptional regulator
DB29_01670	COG2972	Histidine kinase
DB29_01674	COG0673	inositol 2-dehydrogenase activity
DB29_01675	COG1917	Cupin 2, conserved barrel domain protein
DB29_01675	COG4977	sequence-specific DNA binding
DB29_01676	COG2814	Major facilitator Superfamily
DB29_01677	COG3254	rhamnose metabolic process
DB29_01678	COG3347	Dehydrogenase
DB29_01678	COG1028	Short-chain dehydrogenase reductase Sdr
DB29_01679	COG4806	L-rhamnose isomerase
DB29_01679	COG1070	Carbohydrate kinase
DB29_01686	COG1028	Short-chain dehydrogenase reductase Sdr
DB29_01688	COG0726	polysaccharide deacetylase
DB29_01689	COG0673	inositol 2-dehydrogenase activity
DB29_01692	COG0395	ABC-type sugar transport system, permease component
DB29_01693	COG4209	transmembrane transport
DB29_01694	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DB29_01698	COG0584	glycerophosphoryl diester phosphodiesterase
DB29_01699	COG1653	transport
DB29_01700	COG0395	ABC-type sugar transport system, permease component
DB29_01701	COG1175	transmembrane transport
DB29_01702	COG3842	ATPase activity
DB29_01703	COG0584	glycerophosphoryl diester phosphodiesterase
DB29_01704	COG1017	nitric oxide dioxygenase activity
DB29_01704	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DB29_01705	COG1959	2 iron, 2 sulfur cluster binding
DB29_01708	COG1028	Short-chain dehydrogenase reductase Sdr
DB29_01718	COG0457	Tetratricopeptide repeat
DB29_01719	COG0183	Belongs to the thiolase family
DB29_01720	COG0318	PFAM AMP-dependent synthetase and ligase
DB29_01721	COG0318	PFAM AMP-dependent synthetase and ligase
DB29_01722	COG3842	ATPase activity
DB29_01723	COG0395	ABC-type sugar transport system, permease component
DB29_01724	COG1175	transmembrane transport
DB29_01728	COG1917	Cupin 2, conserved barrel domain protein
DB29_01729	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DB29_01730	COG0456	acetyltransferase
DB29_01732	COG0697	spore germination
DB29_01733	COG1012	belongs to the aldehyde dehydrogenase family
DB29_01734	COG1454	alcohol dehydrogenase
DB29_01735	COG2066	Belongs to the glutaminase family
DB29_01736	COG2610	gluconate transmembrane transporter activity
DB29_01738	COG3829	transcription factor binding
DB29_01738	COG3290	protein histidine kinase activity
DB29_01742	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
DB29_01748	COG0395	ABC-type sugar transport system, permease component
DB29_01749	COG1175	transmembrane transport
DB29_01750	COG1940	carbohydrate kinase activity
DB29_01751	COG2723	6-phospho-beta-galactosidase activity
DB29_01752	COG1609	Transcriptional regulator
DB29_01754	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DB29_01754	COG1263	PTS System
DB29_01755	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DB29_01760	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DB29_01761	COG1737	Transcriptional regulator
DB29_01762	COG1132	(ABC) transporter
DB29_01763	COG0789	Transcriptional regulator
DB29_01764	COG1609	Transcriptional regulator
DB29_01773	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DB29_01773	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DB29_01774	COG0628	permease
DB29_01776	COG1528	Iron-storage protein
DB29_01778	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DB29_01779	COG2267	carboxylic ester hydrolase activity
DB29_01780	COG0569	domain protein
DB29_01781	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DB29_01783	COG1051	belongs to the nudix hydrolase family
DB29_01788	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DB29_01789	COG0697	spore germination
DB29_01791	COG0180	Tryptophanyl-tRNA synthetase
DB29_01792	COG2226	methyltransferase
DB29_01795	COG2072	flavoprotein involved in K transport
DB29_01803	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DB29_01809	COG1136	(ABC) transporter
DB29_01811	COG2814	Major facilitator Superfamily
DB29_01812	COG1309	transcriptional regulator
DB29_01814	COG0745	RESPONSE REGULATOR receiver
DB29_01815	COG1136	(ABC) transporter
DB29_01816	COG1819	glycosyl
DB29_01817	COG1396	sequence-specific DNA binding
DB29_01820	COG2207	Transcriptional regulator
DB29_01820	COG1917	Cupin 2, conserved barrel domain protein
DB29_01821	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DB29_01822	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DB29_01824	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DB29_01825	COG5662	AntiSigma factor
DB29_01826	COG1595	DNA-templated transcription, initiation
DB29_01829	COG0747	negative chemotaxis
DB29_01830	COG2755	lipolytic protein G-D-S-L family
DB29_01831	COG1063	alcohol dehydrogenase
DB29_01838	COG3290	protein histidine kinase activity
DB29_01838	COG3829	transcription factor binding
DB29_01839	COG4948	Mandelate Racemase Muconate Lactonizing
DB29_01841	COG0789	Transcriptional regulator
DB29_01844	COG0789	Transcriptional regulator
DB29_01845	COG2226	methyltransferase
DB29_01849	COG0726	polysaccharide deacetylase
DB29_01857	COG0489	protein tyrosine kinase activity
DB29_01858	COG2190	(PTS) system
DB29_01858	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DB29_01858	COG1263	PTS System
DB29_01859	COG3711	transcriptional antiterminator
DB29_01860	COG0860	N-Acetylmuramoyl-L-alanine amidase
DB29_01864	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
DB29_01869	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DB29_01870	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DB29_01871	COG0101	tRNA pseudouridine synthase activity
DB29_01874	COG1122	ATPase activity
DB29_01875	COG0203	ribosomal protein L17
DB29_01876	COG0202	RNA polymerase activity
DB29_01877	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DB29_01878	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DB29_01879	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DB29_01880	COG0024	Methionine aminopeptidase
DB29_01881	COG0563	adenylate kinase activity
DB29_01882	COG0201	protein transport
DB29_01883	COG0200	Binds to the 23S rRNA
DB29_01884	COG1841	ribosomal large subunit assembly
DB29_01885	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DB29_01886	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DB29_01887	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DB29_01888	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DB29_01889	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DB29_01890	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DB29_01891	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DB29_01892	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DB29_01893	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DB29_01894	COG0255	Belongs to the universal ribosomal protein uL29 family
DB29_01895	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DB29_01896	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DB29_01897	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DB29_01898	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DB29_01899	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DB29_01900	COG0089	rRNA binding
DB29_01901	COG0088	Forms part of the polypeptide exit tunnel
DB29_01902	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DB29_01903	COG0051	transcription antitermination factor activity, RNA binding
DB29_01904	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DB29_01905	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DB29_01906	COG0049	tRNA binding
DB29_01907	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DB29_01908	COG1358	cellular component organization or biogenesis
DB29_01909	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DB29_01910	COG0085	RNA polymerase activity
DB29_01911	COG2813	Specifically methylates the guanine in position
DB29_01912	COG0222	ribosome binding
DB29_01913	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DB29_01914	COG0081	regulation of translation
DB29_01915	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DB29_01916	COG0250	Participates in transcription elongation, termination and antitermination
DB29_01917	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DB29_01919	COG3688	RNA-binding protein containing a PIN domain
DB29_01920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DB29_01922	COG0215	cysteine-tRNA ligase activity
DB29_01923	COG1045	serine acetyltransferase
DB29_01924	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DB29_01925	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DB29_01926	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DB29_01927	COG4956	integral membrane protein (PIN domain superfamily)
DB29_01928	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DB29_01929	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DB29_01930	COG0542	response to heat
DB29_01931	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DB29_01932	COG3880	PFAM UvrB UvrC protein
DB29_01935	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DB29_01936	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DB29_01937	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DB29_01938	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DB29_01939	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DB29_01940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DB29_01941	COG0512	Glutamine amidotransferase of anthranilate synthase
DB29_01942	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DB29_01943	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DB29_01944	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DB29_01945	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DB29_01948	COG0037	tRNA processing
DB29_01949	COG0515	serine threonine protein kinase
DB29_01950	COG2304	oxidoreductase activity
DB29_01951	COG2208	phosphoserine phosphatase activity
DB29_01952	COG2851	Citrate transporter
DB29_01953	COG1098	S1 RNA binding domain
DB29_01958	COG0492	ferredoxin-NADP+ reductase activity
DB29_01959	COG1247	-acetyltransferase
DB29_01960	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DB29_01961	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DB29_01962	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DB29_01963	COG3956	TIGRFAM MazG family protein
DB29_01964	COG2244	polysaccharide biosynthetic process
DB29_01966	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DB29_01968	COG2002	toxin-antitoxin pair type II binding
DB29_01969	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DB29_01971	COG0193	aminoacyl-tRNA hydrolase activity
DB29_01972	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DB29_01973	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DB29_01974	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DB29_01976	COG2088	sporulation resulting in formation of a cellular spore
DB29_01977	COG0251	oxidation-reduction process
DB29_01978	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DB29_01979	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DB29_01981	COG4466	Protein conserved in bacteria
DB29_01983	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DB29_01984	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DB29_01985	COG3583	domain protein
DB29_01985	COG3584	3D domain protein
DB29_01986	COG0084	hydrolase, TatD family'
DB29_01991	COG0488	(ABC) transporter
DB29_01993	COG3866	Pectate lyase
DB29_01995	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DB29_01995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DB29_01998	COG2002	toxin-antitoxin pair type II binding
DB29_01999	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DB29_02000	COG2827	Endonuclease containing a URI domain
DB29_02001	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DB29_02002	COG4467	Involved in initiation control of chromosome replication
DB29_02003	COG1774	PSP1 C-terminal conserved region
DB29_02004	COG0470	DNA polymerase III
DB29_02005	COG3870	Protein conserved in bacteria
DB29_02006	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DB29_02007	COG1982	Orn Lys Arg decarboxylase major
DB29_02010	COG1012	belongs to the aldehyde dehydrogenase family
DB29_02012	COG2204	response regulator
DB29_02018	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DB29_02019	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DB29_02020	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DB29_02022	COG0740	serine-type endopeptidase activity
DB29_02023	COG0590	tRNA wobble adenosine to inosine editing
DB29_02024	COG0747	negative chemotaxis
DB29_02027	COG0444	Belongs to the ABC transporter superfamily
DB29_02028	COG4608	Belongs to the ABC transporter superfamily
DB29_02030	COG0765	amino acid transport
DB29_02031	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DB29_02033	COG1012	belongs to the aldehyde dehydrogenase family
DB29_02037	COG0006	proline dipeptidase activity
DB29_02041	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DB29_02042	COG3829	transcription factor binding
DB29_02043	COG2508	Transcriptional regulator
DB29_02044	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DB29_02045	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DB29_02047	COG0517	IMP dehydrogenase activity
DB29_02047	COG0516	GMP reductase activity
DB29_02051	COG1028	Short-chain dehydrogenase reductase Sdr
DB29_02053	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DB29_02054	COG0187	DNA topoisomerase II activity
DB29_02056	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DB29_02057	COG2501	S4 domain
DB29_02058	COG0592	DNA-directed DNA polymerase activity
DB29_02059	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DB29_02060	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DB29_02061	COG0594	ribonuclease P activity
DB29_02062	COG0706	membrane insertase activity
DB29_02063	COG1847	R3H domain protein
DB29_02065	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DB29_02066	COG0445	tRNA wobble uridine modification
DB29_02067	COG0357	Ribosomal RNA small subunit methyltransferase G
DB29_02068	COG1475	DNA binding
DB29_02069	COG1192	Involved in chromosome partitioning
DB29_02070	COG1475	DNA binding
DB29_02071	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DB29_02073	COG3949	Membrane
DB29_02074	COG4481	Protein conserved in bacteria
DB29_02075	COG0012	GTP binding
DB29_02076	COG0360	Binds together with S18 to 16S ribosomal RNA
DB29_02077	COG0629	single-stranded DNA binding
DB29_02078	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DB29_02080	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
DB29_02081	COG0359	binds to the 23S rRNA
DB29_02082	COG0305	Participates in initiation and elongation during chromosome replication
DB29_02083	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DB29_02084	COG0745	RESPONSE REGULATOR receiver
DB29_02085	COG5002	protein histidine kinase activity
DB29_02087	COG4853	Protein conserved in bacteria
DB29_02088	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DB29_02089	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DB29_02090	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DB29_02096	COG1063	alcohol dehydrogenase
DB29_02097	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DB29_02098	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DB29_02100	COG0235	Class ii aldolase
DB29_02102	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DB29_02102	COG3933	PFAM sigma-54 factor interaction domain-containing protein
DB29_02104	COG3716	PTS system mannose fructose sorbose family IID component
DB29_02108	COG1131	(ABC) transporter
DB29_02115	COG0601	transmembrane transport
DB29_02117	COG0444	Belongs to the ABC transporter superfamily
DB29_02118	COG4608	Belongs to the ABC transporter superfamily
DB29_02122	COG3275	phosphorelay sensor kinase activity
DB29_02123	COG3279	Response regulator of the LytR AlgR family
DB29_02124	COG1966	Carbon starvation protein
DB29_02129	COG1595	DNA-templated transcription, initiation
DB29_02132	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DB29_02133	COG1802	Transcriptional regulator
DB29_02134	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DB29_02137	COG0372	Belongs to the citrate synthase family
DB29_02138	COG0583	DNA-binding transcription factor activity
DB29_02141	COG2186	Transcriptional regulator
DB29_02142	COG2186	Transcriptional regulator
DB29_02143	COG0277	FAD linked oxidase domain protein
DB29_02144	COG0247	lactate metabolic process
DB29_02145	COG0579	oxidoreductase
DB29_02146	COG2508	Transcriptional regulator
DB29_02147	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DB29_02148	COG0402	S-adenosylhomocysteine deaminase activity
DB29_02150	COG2182	Extracellular solute-binding protein
DB29_02151	COG1175	transmembrane transport
DB29_02152	COG3833	ABC-type maltose transport systems, permease component
DB29_02153	COG1609	Transcriptional regulator
DB29_02154	COG2031	fatty acid transporter
DB29_02155	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DB29_02156	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DB29_02158	COG0346	lactoylglutathione lyase activity
DB29_02159	COG0813	purine-nucleoside phosphorylase activity
DB29_02160	COG0523	cobalamin synthesis protein
DB29_02161	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DB29_02162	COG1193	negative regulation of DNA recombination
DB29_02163	COG1307	EDD domain protein, DegV family
DB29_02172	COG2807	transmembrane transport
DB29_02175	COG0745	RESPONSE REGULATOR receiver
DB29_02179	COG2154	pterin-4-alpha-carbinolamine dehydratase
DB29_02180	COG0733	neurotransmitter:sodium symporter activity
DB29_02186	COG1114	Component of the transport system for branched-chain amino acids
DB29_02190	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DB29_02191	COG3290	protein histidine kinase activity
DB29_02192	COG4565	transcriptional regulatory protein
DB29_02193	COG0471	metal ion transport
DB29_02197	COG2972	Histidine kinase
DB29_02197	COG0745	RESPONSE REGULATOR receiver
DB29_02201	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DB29_02201	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DB29_02210	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
DB29_02212	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DB29_02213	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DB29_02214	COG5504	Zn-dependent protease
DB29_02215	COG0789	Transcriptional regulator
DB29_02217	COG1597	lipid kinase activity
DB29_02218	COG2323	membrane
DB29_02219	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DB29_02220	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DB29_02221	COG1132	(ABC) transporter
DB29_02222	COG0753	catalase activity
DB29_02224	COG2814	Major facilitator Superfamily
DB29_02225	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DB29_02226	COG0840	transmembrane signaling receptor activity
DB29_02228	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DB29_02229	COG0561	phosphatase activity
DB29_02231	COG0803	Belongs to the bacterial solute-binding protein 9 family
DB29_02232	COG1121	(ABC) transporter
DB29_02233	COG1321	iron dependent repressor
DB29_02233	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DB29_02234	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DB29_02237	COG2814	Major facilitator Superfamily
DB29_02238	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DB29_02239	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DB29_02239	COG0551	DNA topoisomerase type I activity
DB29_02240	COG1785	Belongs to the alkaline phosphatase family
DB29_02242	COG0024	Methionine aminopeptidase
DB29_02243	COG2268	Band 7 protein
DB29_02246	COG0723	plastoquinol--plastocyanin reductase activity
DB29_02246	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DB29_02247	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DB29_02248	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DB29_02250	COG0513	Belongs to the DEAD box helicase family
DB29_02257	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DB29_02260	COG2986	histidine ammonia-lyase
DB29_02261	COG0351	phosphomethylpyrimidine kinase
DB29_02263	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DB29_02265	COG0004	ammonium transporteR
DB29_02270	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DB29_02271	COG0456	acetyltransferase
DB29_02272	COG2363	Small membrane protein
DB29_02274	COG3773	Cell wall hydrolase
DB29_02276	COG1725	Transcriptional regulator
DB29_02277	COG1131	(ABC) transporter
DB29_02278	COG4152	abc transporter atp-binding protein
DB29_02279	COG1668	transmembrane transport
DB29_02283	COG1024	Enoyl-CoA hydratase
DB29_02284	COG0280	phosphate acetyltransferase
DB29_02285	COG0095	Lipoate-protein ligase
DB29_02287	COG1301	dicarboxylic acid transport
DB29_02288	COG1078	dGTPase activity
DB29_02289	COG3465	dGTPase activity
DB29_02292	COG3764	Sortase (surface protein transpeptidase)
DB29_02297	COG1164	Oligoendopeptidase f
DB29_02299	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DB29_02300	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DB29_02301	COG0010	Belongs to the arginase family
DB29_02304	COG0018	arginyl-trna synthetase
DB29_02305	COG2839	Protein conserved in bacteria
DB29_02306	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DB29_02307	COG0247	lactate metabolic process
DB29_02307	COG2181	nitrate reductase activity
DB29_02308	COG0183	Belongs to the thiolase family
DB29_02309	COG1250	3-hydroxyacyl-CoA dehydrogenase
DB29_02310	COG1960	acyl-CoA dehydrogenase activity
DB29_02312	COG3343	RNA polymerase activity
DB29_02313	COG0504	CTP synthase activity
DB29_02316	COG0191	fructose-bisphosphate aldolase activity
DB29_02317	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DB29_02318	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DB29_02319	COG1494	fructose-1,6-bisphosphatase
DB29_02320	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DB29_02321	COG0254	rRNA binding
DB29_02322	COG1435	thymidine kinase activity
DB29_02324	COG0446	pyridine nucleotide-disulphide oxidoreductase
DB29_02325	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DB29_02329	COG0009	L-threonylcarbamoyladenylate synthase
DB29_02331	COG1971	Probably functions as a manganese efflux pump
DB29_02334	COG0698	ribose 5-phosphate isomerase
DB29_02335	COG4475	Protein of unknown function (DUF436)
DB29_02336	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DB29_02337	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DB29_02338	COG0456	acetyltransferase
DB29_02339	COG1404	Belongs to the peptidase S8 family
DB29_02342	COG0356	it plays a direct role in the translocation of protons across the membrane
DB29_02343	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DB29_02344	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DB29_02345	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DB29_02346	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DB29_02347	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DB29_02348	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DB29_02349	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DB29_02353	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DB29_02354	COG2385	sporulation resulting in formation of a cellular spore
DB29_02355	COG0739	heme binding
DB29_02356	COG2076	Multidrug Resistance protein
DB29_02357	COG2076	Multidrug Resistance protein
DB29_02358	COG1609	Transcriptional regulator
DB29_02359	COG1077	Cell shape determining protein MreB Mrl
DB29_02360	COG4786	Flagellar basal body rod
DB29_02361	COG4786	Flagellar basal body rod
DB29_02366	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DB29_02368	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DB29_02371	COG2318	DinB family
DB29_02373	COG0791	NLP P60 protein
DB29_02373	COG1388	LysM domain
DB29_02374	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DB29_02376	COG2388	GCN5-related N-acetyl-transferase
DB29_02377	COG1316	TRANSCRIPTIONal
DB29_02379	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DB29_02380	COG0772	Belongs to the SEDS family
DB29_02383	COG0590	tRNA wobble adenosine to inosine editing
DB29_02385	COG1316	TRANSCRIPTIONal
DB29_02386	COG3944	biosynthesis protein
DB29_02387	COG0489	protein tyrosine kinase activity
DB29_02388	COG4464	protein tyrosine phosphatase activity
DB29_02411	COG2723	6-phospho-beta-galactosidase activity
DB29_02412	COG3711	transcriptional antiterminator
DB29_02413	COG3711	transcriptional antiterminator
DB29_02416	COG1959	2 iron, 2 sulfur cluster binding
DB29_02417	COG2910	NAD(P)H-binding
DB29_02420	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DB29_02427	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DB29_02429	COG0395	ABC-type sugar transport system, permease component
DB29_02430	COG1175	transmembrane transport
DB29_02432	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DB29_02433	COG1984	allophanate hydrolase subunit 2
DB29_02434	COG1914	H( )-stimulated, divalent metal cation uptake system
DB29_02435	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DB29_02437	COG0778	Nitroreductase
DB29_02438	COG1609	Transcriptional regulator
DB29_02439	COG1621	beta-fructofuranosidase activity
DB29_02440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DB29_02440	COG1263	PTS System
DB29_02442	COG0300	oxidoreductase activity
DB29_02445	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DB29_02451	COG1959	2 iron, 2 sulfur cluster binding
DB29_02452	COG0537	adenosine 5'-monophosphoramidase activity
DB29_02455	COG1116	anion transmembrane transporter activity
DB29_02456	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DB29_02459	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DB29_02461	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DB29_02464	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DB29_02465	COG2080	2 iron, 2 sulfur cluster binding
DB29_02467	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DB29_02468	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DB29_02469	COG2508	Transcriptional regulator
DB29_02471	COG3195	allantoin biosynthetic process
DB29_02471	COG3648	Uricase
DB29_02473	COG1288	antiporter activity
DB29_02474	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DB29_02475	COG0154	amidase activity
DB29_02476	COG3361	conserved protein (COG2071)
DB29_02488	COG0693	protein deglycase activity
DB29_02490	COG1116	anion transmembrane transporter activity
DB29_02491	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DB29_02495	COG5658	integral membrane protein
DB29_02496	COG0640	Transcriptional regulator
DB29_02497	COG0583	DNA-binding transcription factor activity
DB29_02499	COG1115	amino acid carrier protein
DB29_02500	COG1028	Short-chain dehydrogenase reductase Sdr
DB29_02504	COG0697	spore germination
DB29_02505	COG0814	amino acid
DB29_02509	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DB29_02511	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DB29_02512	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DB29_02513	COG2244	polysaccharide biosynthetic process
DB29_02520	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DB29_02523	COG1091	dTDP-4-dehydrorhamnose reductase activity
DB29_02531	COG2249	NAD(P)H dehydrogenase (quinone) activity
DB29_02532	COG1733	regulation of RNA biosynthetic process
DB29_02540	COG1943	Transposase
DB29_02546	COG1486	melibiose metabolic process
DB29_02549	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DB29_02549	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DB29_02550	COG1447	Phosphotransferase system cellobiose-specific component IIA
DB29_02552	COG2971	BadF BadG BcrA BcrD
DB29_02554	COG0583	DNA-binding transcription factor activity
DB29_02556	COG0747	negative chemotaxis
DB29_02557	COG0601	transmembrane transport
DB29_02558	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DB29_02559	COG0444	Belongs to the ABC transporter superfamily
DB29_02560	COG4608	Belongs to the ABC transporter superfamily
DB29_02561	COG1473	amidohydrolase
DB29_02562	COG0471	metal ion transport
DB29_02564	COG1473	amidohydrolase
DB29_02568	COG1840	ABC-type Fe3 transport system, periplasmic component
DB29_02569	COG3842	ATPase activity
DB29_02571	COG2972	Histidine kinase
DB29_02572	COG4753	response regulator
DB29_02572	COG2207	Transcriptional regulator
DB29_02575	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DB29_02576	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DB29_02577	COG2205	protein histidine kinase activity
DB29_02578	COG0745	RESPONSE REGULATOR receiver
DB29_02579	COG1131	(ABC) transporter
DB29_02589	COG1741	Belongs to the pirin family
DB29_02590	COG1733	regulation of RNA biosynthetic process
DB29_02591	COG0402	S-adenosylhomocysteine deaminase activity
DB29_02594	COG3546	catalase activity
DB29_02599	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DB29_02600	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DB29_02602	COG1028	Short-chain dehydrogenase reductase Sdr
DB29_02604	COG0318	PFAM AMP-dependent synthetase and ligase
DB29_02607	COG2814	Major facilitator Superfamily
DB29_02608	COG1063	alcohol dehydrogenase
DB29_02609	COG1028	Short-chain dehydrogenase reductase Sdr
DB29_02610	COG1349	DNA-binding transcription factor activity
DB29_02611	COG0698	ribose 5-phosphate isomerase
DB29_02612	COG2376	Dihydroxyacetone kinase
DB29_02613	COG2376	Dihydroxyacetone kinase
DB29_02614	COG1494	fructose-1,6-bisphosphatase
DB29_02615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DB29_02619	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DB29_02620	COG1609	Transcriptional regulator
DB29_02621	COG4682	membrane
DB29_02632	COG1794	racemase activity, acting on amino acids and derivatives
DB29_02635	COG2207	Transcriptional regulator
DB29_02635	COG4753	response regulator
DB29_02636	COG2972	Histidine kinase
DB29_02637	COG1653	transport
DB29_02639	COG0395	ABC-type sugar transport system, permease component
DB29_02640	COG0445	tRNA wobble uridine modification
DB29_02643	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DB29_02643	COG1263	PTS System
DB29_02644	COG1737	Transcriptional regulator
DB29_02650	COG1349	DNA-binding transcription factor activity
DB29_02652	COG3414	Phosphotransferase system galactitol-specific IIB component
DB29_02653	COG3775	system Galactitol-specific IIC component
DB29_02654	COG1063	alcohol dehydrogenase
DB29_02661	COG3655	Transcriptional regulator
DB29_02662	COG3739	integral membrane protein
DB29_02663	COG3848	Pyruvate phosphate dikinase
DB29_02663	COG0574	Belongs to the PEP-utilizing enzyme family
DB29_02665	COG0583	DNA-binding transcription factor activity
DB29_02666	COG0730	response to heat
DB29_02667	COG2972	Histidine kinase
DB29_02668	COG4753	response regulator
DB29_02668	COG2207	Transcriptional regulator
DB29_02672	COG1175	transmembrane transport
DB29_02673	COG0395	ABC-type sugar transport system, permease component
DB29_02675	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DB29_02679	COG2190	(PTS) system
DB29_02679	COG1263	PTS System
DB29_02679	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DB29_02682	COG0745	RESPONSE REGULATOR receiver
DB29_02682	COG2972	Histidine kinase
DB29_02683	COG3279	Response regulator of the LytR AlgR family
DB29_02687	COG1396	sequence-specific DNA binding
DB29_02692	COG1132	(ABC) transporter
DB29_02697	COG1131	(ABC) transporter
DB29_02700	COG0745	RESPONSE REGULATOR receiver
DB29_02701	COG3850	Histidine kinase
DB29_02701	COG5002	protein histidine kinase activity
DB29_02706	COG0483	inositol monophosphate 1-phosphatase activity
DB29_02714	COG1609	Transcriptional regulator
DB29_02715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DB29_02716	COG1869	D-ribose catabolic process
DB29_02717	COG1129	ABC transporter
DB29_02718	COG1172	Belongs to the binding-protein-dependent transport system permease family
DB29_02719	COG1879	ABC-type sugar transport system periplasmic component
DB29_02722	COG0300	oxidoreductase activity
DB29_02728	COG1376	ErfK ybiS ycfS ynhG family protein
DB29_02729	COG2312	Erythromycin esterase
DB29_02731	COG1028	Short-chain dehydrogenase reductase Sdr
DB29_02734	COG2207	Transcriptional regulator
DB29_02735	COG1131	(ABC) transporter
DB29_02737	COG1378	Sugar-specific transcriptional regulator TrmB
DB29_02738	COG0697	spore germination
DB29_02742	COG1609	Transcriptional regulator
DB29_02743	COG2182	Extracellular solute-binding protein
DB29_02744	COG1175	transmembrane transport
DB29_02745	COG3833	ABC-type maltose transport systems, permease component
DB29_02747	COG1874	Beta-galactosidase
DB29_02750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DB29_02751	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DB29_02752	COG0789	Transcriptional regulator
DB29_02756	COG0693	protein deglycase activity
DB29_02758	COG3037	sugar-specific permease SgaT UlaA
DB29_02761	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DB29_02765	COG0395	ABC-type sugar transport system, permease component
DB29_02766	COG1175	transmembrane transport
DB29_02767	COG1653	transport
DB29_02768	COG1136	(ABC) transporter
DB29_02769	COG0577	efflux transmembrane transporter activity
DB29_02771	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DB29_02772	COG0697	spore germination
DB29_02776	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DB29_02776	COG2207	Transcriptional regulator
DB29_02777	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DB29_02778	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DB29_02779	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DB29_02780	COG2819	hydrolase of the alpha beta superfamily
DB29_02783	COG2602	Beta-lactamase
DB29_02786	COG0840	transmembrane signaling receptor activity
DB29_02787	COG1609	Transcriptional regulator
DB29_02789	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DB29_02790	COG2207	Transcriptional regulator
DB29_02792	COG1609	Transcriptional regulator
DB29_02793	COG0673	inositol 2-dehydrogenase activity
DB29_02796	COG0395	ABC-type sugar transport system, permease component
DB29_02797	COG1082	Xylose isomerase domain protein TIM barrel
DB29_02800	COG2197	response regulator
DB29_02806	COG1366	Belongs to the anti-sigma-factor antagonist family
DB29_02811	COG2720	vancomycin resistance protein
DB29_02813	COG2135	peptidase activity
DB29_02819	COG0542	response to heat
DB29_02820	COG0860	N-Acetylmuramoyl-L-alanine amidase
DB29_02828	COG2311	Membrane
DB29_02829	COG1940	carbohydrate kinase activity
DB29_02831	COG1175	transmembrane transport
DB29_02832	COG0395	ABC-type sugar transport system, permease component
DB29_02833	COG0673	inositol 2-dehydrogenase activity
DB29_02834	COG0673	inositol 2-dehydrogenase activity
DB29_02836	COG0596	Alpha beta hydrolase
DB29_02838	COG1028	Short-chain dehydrogenase reductase Sdr
DB29_02840	COG0477	Major facilitator Superfamily
DB29_02841	COG1309	transcriptional regulator
DB29_02842	COG2226	methyltransferase
DB29_02843	COG1063	alcohol dehydrogenase
DB29_02846	COG2329	Antibiotic biosynthesis monooxygenase
DB29_02847	COG5386	Cell surface protein
DB29_02848	COG5386	Cell surface protein
DB29_02851	COG1120	ATPase activity
DB29_02852	COG4509	Sortase family
DB29_02854	COG1253	flavin adenine dinucleotide binding
DB29_02855	COG2113	Glycine betaine
DB29_02857	COG3546	catalase activity
DB29_02858	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DB29_02859	COG1063	alcohol dehydrogenase
DB29_02861	COG1587	Uroporphyrinogen-III synthase
DB29_02864	COG1131	(ABC) transporter
DB29_02867	COG1309	transcriptional regulator
DB29_02869	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DB29_02873	COG2323	membrane
DB29_02875	COG0583	DNA-binding transcription factor activity
DB29_02876	COG0431	NADPH-dependent FMN reductase
DB29_02879	COG1116	anion transmembrane transporter activity
DB29_02880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DB29_02881	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DB29_02882	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DB29_02883	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DB29_02884	COG0583	DNA-binding transcription factor activity
DB29_02885	COG0640	Transcriptional regulator
DB29_02887	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DB29_02888	COG2032	superoxide dismutase activity
DB29_02890	COG1028	Short-chain dehydrogenase reductase Sdr
DB29_02892	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DB29_02894	COG1609	Transcriptional regulator
DB29_02902	COG4585	Histidine kinase
DB29_02903	COG2197	response regulator
DB29_02904	COG4149	molybdate abc transporter
DB29_02905	COG0725	ABC transporter, periplasmic molybdate-binding protein
DB29_02906	COG3534	alpha-L-arabinofuranosidase
DB29_02908	COG3507	Belongs to the glycosyl hydrolase 43 family
DB29_02909	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DB29_02912	COG1682	transport, permease protein
DB29_02913	COG1134	teichoic acid transport
DB29_02914	COG1694	Mazg nucleotide pyrophosphohydrolase
DB29_02920	COG1609	Transcriptional regulator
DB29_02923	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DB29_02924	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DB29_02925	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DB29_02927	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DB29_02929	COG2217	Heavy metal translocating P-type atpase
DB29_02932	COG3414	Phosphotransferase system galactitol-specific IIB component
DB29_02933	COG3775	system Galactitol-specific IIC component
DB29_02934	COG1063	alcohol dehydrogenase
DB29_02936	COG1063	alcohol dehydrogenase
DB29_02939	COG1388	LysM domain
DB29_02940	COG1619	proteins homologs of microcin C7 resistance protein MccF
DB29_02941	COG1263	PTS System
DB29_02941	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DB29_02942	COG3711	transcriptional antiterminator
DB29_02944	COG2197	response regulator
DB29_02945	COG4585	Histidine kinase
DB29_02948	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DB29_02949	COG1228	amidohydrolase
DB29_02951	COG0402	S-adenosylhomocysteine deaminase activity
DB29_02956	COG0457	Tetratricopeptide repeat
DB29_02957	COG1078	dGTPase activity
DB29_02967	COG1418	mRNA catabolic process
DB29_02968	COG0124	histidyl-tRNA synthetase
DB29_02970	COG2261	transglycosylase associated protein
DB29_02973	COG0456	acetyltransferase
DB29_02977	COG1653	transport
DB29_02979	COG0395	ABC-type sugar transport system, permease component
DB29_02981	COG0501	Belongs to the peptidase M48B family
DB29_02982	COG5504	Zn-dependent protease
DB29_02983	COG2247	cell wall binding repeat
DB29_02983	COG0860	N-Acetylmuramoyl-L-alanine amidase
DB29_02985	COG1368	sulfuric ester hydrolase activity
DB29_02988	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DB29_02989	COG0384	phenazine biosynthesis protein PhzF
DB29_02991	COG0673	inositol 2-dehydrogenase activity
DB29_02992	COG2207	Transcriptional regulator
DB29_02992	COG1917	Cupin 2, conserved barrel domain protein
DB29_02994	COG0673	inositol 2-dehydrogenase activity
DB29_02995	COG1653	transport
DB29_02996	COG1175	transmembrane transport
DB29_02997	COG0395	ABC-type sugar transport system, permease component
DB29_02999	COG2207	Transcriptional regulator
DB29_02999	COG3708	Transcriptional regulator
DB29_03001	COG0673	inositol 2-dehydrogenase activity
DB29_03002	COG4977	sequence-specific DNA binding
DB29_03003	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DB29_03004	COG1175	transmembrane transport
DB29_03005	COG0395	ABC-type sugar transport system, permease component
DB29_03010	COG3420	alginic acid biosynthetic process
DB29_03012	COG1309	transcriptional regulator
DB29_03019	COG1609	Transcriptional regulator
DB29_03022	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DB29_03024	COG1482	cell wall glycoprotein biosynthetic process
DB29_03027	COG1968	undecaprenyl-diphosphatase activity
DB29_03028	COG2270	Major facilitator Superfamily
DB29_03029	COG3835	regulator
DB29_03030	COG0277	FAD linked oxidase domain protein
DB29_03031	COG0247	lactate metabolic process
DB29_03032	COG1116	anion transmembrane transporter activity
DB29_03035	COG0456	acetyltransferase
DB29_03036	COG1846	Transcriptional regulator
DB29_03040	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DB29_03043	COG3730	PTS system glucitol sorbitol-specific
DB29_03044	COG3732	PTS system glucitol sorbitol-specific
DB29_03048	COG2217	Heavy metal translocating P-type atpase
DB29_03050	COG0577	efflux transmembrane transporter activity
DB29_03051	COG1136	(ABC) transporter
DB29_03052	COG5002	protein histidine kinase activity
DB29_03053	COG0745	RESPONSE REGULATOR receiver
DB29_03055	COG1940	carbohydrate kinase activity
DB29_03056	COG4187	Peptidase family M20/M25/M40
DB29_03057	COG2814	Major facilitator Superfamily
DB29_03058	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DB29_03059	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DB29_03060	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DB29_03062	COG1368	sulfuric ester hydrolase activity
DB29_03063	COG0516	GMP reductase activity
DB29_03071	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DB29_03074	COG1176	ABC-type spermidine putrescine transport system, permease component I
DB29_03080	COG0589	response to stress
DB29_03082	COG1105	Belongs to the carbohydrate kinase PfkB family
DB29_03083	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DB29_03083	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DB29_03083	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DB29_03084	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DB29_03084	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DB29_03084	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DB29_03087	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DB29_03091	COG0583	DNA-binding transcription factor activity
DB29_03092	COG0655	NAD(P)H dehydrogenase (quinone) activity
DB29_03094	COG1309	transcriptional regulator
DB29_03095	COG0842	Transport permease protein
DB29_03096	COG1131	(ABC) transporter
DB29_03101	COG1473	amidohydrolase
DB29_03102	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DB29_03110	COG0438	transferase activity, transferring glycosyl groups
DB29_03113	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DB29_03115	COG1215	transferase activity, transferring glycosyl groups
DB29_03116	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DB29_03136	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DB29_03137	COG2169	Transcriptional regulator
DB29_03138	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DB29_03139	COG0673	inositol 2-dehydrogenase activity
DB29_03140	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DB29_03141	COG0561	phosphatase activity
DB29_03142	COG2318	DinB family
DB29_03143	COG2378	regulation of single-species biofilm formation
DB29_03145	COG1028	Short-chain dehydrogenase reductase Sdr
DB29_03146	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DB29_03148	COG2197	response regulator
DB29_03149	COG2203	Gaf domain
DB29_03149	COG4585	Histidine kinase
DB29_03152	COG2112	serine threonine protein kinase
DB29_03154	COG1959	2 iron, 2 sulfur cluster binding
DB29_03156	COG0800	Aldolase
DB29_03159	COG1131	(ABC) transporter
DB29_03160	COG1725	Transcriptional regulator
DB29_03165	COG1396	sequence-specific DNA binding
DB29_03167	COG1472	Belongs to the glycosyl hydrolase 3 family
DB29_03169	COG1175	transmembrane transport
DB29_03170	COG0395	ABC-type sugar transport system, permease component
DB29_03171	COG3842	ATPase activity
DB29_03174	COG1609	Transcriptional regulator
DB29_03175	COG4209	transmembrane transport
DB29_03176	COG0395	ABC-type sugar transport system, permease component
DB29_03178	COG1621	beta-fructofuranosidase activity
DB29_03180	COG1028	Short-chain dehydrogenase reductase Sdr
DB29_03181	COG1388	LysM domain
DB29_03181	COG3858	chitin binding
DB29_03183	COG1335	isochorismatase
DB29_03184	COG4112	unkown
DB29_03185	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DB29_03186	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DB29_03187	COG1780	Probably involved in ribonucleotide reductase function
DB29_03189	COG1215	transferase activity, transferring glycosyl groups
DB29_03190	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DB29_03191	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DB29_03193	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DB29_03194	COG0463	Glycosyl transferase, family 2
DB29_03194	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DB29_03195	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DB29_03195	COG1215	transferase activity, transferring glycosyl groups
DB29_03196	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DB29_03197	COG4193	domain, Protein
DB29_03198	COG1316	TRANSCRIPTIONal
DB29_03201	COG4608	Belongs to the ABC transporter superfamily
DB29_03202	COG0601	transmembrane transport
DB29_03204	COG4166	transmembrane transport
DB29_03205	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DB29_03206	COG1739	Uncharacterized protein family UPF0029
DB29_03209	COG1307	EDD domain protein, DegV family
DB29_03211	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DB29_03214	COG2747	anti-sigma28 factor FlgM
DB29_03216	COG1256	bacterial-type flagellum assembly
DB29_03216	COG4786	Flagellar basal body rod
DB29_03217	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DB29_03218	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
DB29_03219	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DB29_03220	COG1334	flagellar protein FlaG
DB29_03221	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DB29_03222	COG1516	flagellar protein fliS
DB29_03225	COG1278	Cold shock
DB29_03226	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DB29_03227	COG0653	protein targeting
DB29_03228	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DB29_03229	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DB29_03230	COG2884	Cell division ATP-binding protein ftsE
DB29_03231	COG2177	Part of the ABC transporter FtsEX involved in
DB29_03232	COG0739	heme binding
DB29_03233	COG0793	Belongs to the peptidase S41A family
DB29_03233	COG3409	Peptidoglycan-binding domain 1 protein
DB29_03237	COG0556	nucleotide-excision repair
DB29_03238	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DB29_03239	COG3595	metallopeptidase activity
DB29_03240	COG1950	PFAM Membrane protein of
DB29_03241	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DB29_03242	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DB29_03243	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DB29_03244	COG0546	phosphoglycolate phosphatase activity
DB29_03245	COG0110	maltose O-acetyltransferase activity
DB29_03246	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DB29_03247	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DB29_03249	COG0131	Imidazoleglycerol-phosphate dehydratase
DB29_03250	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DB29_03251	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DB29_03252	COG0107	imidazoleglycerol-phosphate synthase activity
DB29_03253	COG0140	phosphoribosyl-ATP diphosphatase activity
DB29_03253	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DB29_03255	COG0697	spore germination
DB29_03256	COG2124	cytochrome p450
DB29_03259	COG0492	ferredoxin-NADP+ reductase activity
DB29_03260	COG1051	belongs to the nudix hydrolase family
DB29_03261	COG1660	Displays ATPase and GTPase activities
DB29_03262	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DB29_03263	COG1481	regulation of sporulation
DB29_03264	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DB29_03265	COG1174	glycine betaine transport
DB29_03266	COG1732	Glycine betaine
DB29_03267	COG1174	glycine betaine transport
DB29_03268	COG0517	IMP dehydrogenase activity
DB29_03268	COG1125	glycine betaine transport
DB29_03270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DB29_03271	COG0740	serine-type endopeptidase activity
DB29_03272	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DB29_03278	COG0126	phosphoglycerate kinase activity
DB29_03279	COG0149	triose-phosphate isomerase activity
DB29_03280	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DB29_03281	COG0148	phosphopyruvate hydratase activity
DB29_03282	COG1802	Transcriptional regulator
DB29_03283	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DB29_03284	COG1012	belongs to the aldehyde dehydrogenase family
DB29_03285	COG4948	Mandelate Racemase Muconate Lactonizing
DB29_03290	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DB29_03291	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DB29_03293	COG1647	Serine aminopeptidase, S33
DB29_03294	COG0557	exoribonuclease II activity
DB29_03295	COG2259	Doxx family
DB29_03296	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DB29_03302	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DB29_03304	COG0726	polysaccharide deacetylase
DB29_03306	COG4533	DNA binding
DB29_03308	COG1024	Enoyl-CoA hydratase
DB29_03308	COG1250	3-hydroxyacyl-CoA dehydrogenase
DB29_03309	COG0183	Belongs to the thiolase family
DB29_03310	COG1960	acyl-CoA dehydrogenase activity
DB29_03311	COG1393	Belongs to the ArsC family
DB29_03312	COG0509	glycine decarboxylation via glycine cleavage system
DB29_03314	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DB29_03315	COG2011	ABC-type metal ion transport system permease component
DB29_03316	COG1464	Belongs to the NlpA lipoprotein family
DB29_03318	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DB29_03319	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DB29_03321	COG0396	ATPase activity
DB29_03322	COG0719	Fe-S assembly protein
DB29_03323	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DB29_03324	COG0822	iron-sulfur transferase activity
DB29_03325	COG0719	Fe-S assembly protein
DB29_03326	COG2224	Isocitrate lyase
DB29_03328	COG3711	transcriptional antiterminator
DB29_03329	COG2723	6-phospho-beta-galactosidase activity
DB29_03330	COG2723	6-phospho-beta-galactosidase activity
DB29_03331	COG2226	methyltransferase
DB29_03332	COG0667	Aldo Keto reductase
DB29_03333	COG2207	Transcriptional regulator
DB29_03333	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DB29_03343	COG1801	Protein of unknown function DUF72
DB29_03344	COG0730	response to heat
DB29_03345	COG0737	Belongs to the 5'-nucleotidase family
DB29_03346	COG3377	Domain of unknown function (DUF1805)
DB29_03347	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DB29_03350	COG1757	Na H antiporter
DB29_03351	COG0739	heme binding
DB29_03352	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DB29_03354	COG4470	Protein conserved in bacteria
DB29_03356	COG2445	Protein of unknown function DUF86
DB29_03357	COG0647	UMP catabolic process
DB29_03358	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DB29_03359	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DB29_03360	COG0460	homoserine dehydrogenase
DB29_03361	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DB29_03362	COG0083	homoserine kinase activity
DB29_03363	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DB29_03364	COG4837	Protein of unknown function (DUF1462)
DB29_03365	COG1252	NADH dehydrogenase
DB29_03366	COG4844	belongs to the
DB29_03368	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DB29_03369	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DB29_03371	COG0316	Belongs to the HesB IscA family
DB29_03372	COG0765	amino acid transport
DB29_03373	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DB29_03376	COG3711	transcriptional antiterminator
DB29_03377	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DB29_03378	COG0246	Mannitol dehydrogenase
DB29_03379	COG0492	ferredoxin-NADP+ reductase activity
DB29_03380	COG1252	NADH dehydrogenase
DB29_03382	COG3584	3D domain protein
DB29_03383	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
DB29_03384	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DB29_03386	COG1943	Transposase
DB29_03387	COG2056	Na+-H+ antiporter family
DB29_03388	COG0776	regulation of translation
DB29_03389	COG1295	ribonuclease BN
DB29_03390	COG1854	S-ribosylhomocysteine lyase activity
DB29_03391	COG1522	sequence-specific DNA binding
DB29_03392	COG0436	Aminotransferase
DB29_03393	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DB29_03395	COG1098	S1 RNA binding domain
DB29_03396	COG2155	Conserved Protein
DB29_03398	COG1979	alcohol dehydrogenase
DB29_03399	COG1181	Belongs to the D-alanine--D-alanine ligase family
DB29_03400	COG0166	Belongs to the GPI family
DB29_03403	COG1227	inorganic diphosphatase activity
DB29_03404	COG0109	protoheme IX farnesyltransferase activity
DB29_03405	COG4846	Membrane protein involved in cytochrome C biogenesis
DB29_03409	COG1823	symporter activity
DB29_03410	COG0671	phosphoesterase, PA-phosphatase related
DB29_03411	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DB29_03412	COG4605	iron ion homeostasis
DB29_03413	COG4604	ABC transporter, ATP-binding protein
DB29_03415	COG1943	Transposase
DB29_03417	COG1428	Deoxynucleoside kinase
DB29_03418	COG1428	Deoxynucleoside kinase
DB29_03419	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DB29_03422	COG2814	Major facilitator Superfamily
DB29_03423	COG0494	nUDIX hydrolase
DB29_03424	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DB29_03425	COG1116	anion transmembrane transporter activity
DB29_03426	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DB29_03427	COG1506	peptidase
DB29_03429	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DB29_03430	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DB29_03431	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DB29_03432	COG2267	carboxylic ester hydrolase activity
DB29_03433	COG0288	reversible hydration of carbon dioxide
DB29_03434	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DB29_03436	COG2814	Major facilitator Superfamily
DB29_03437	COG0039	L-malate dehydrogenase activity
DB29_03438	COG0495	leucyl-tRNA aminoacylation
DB29_03443	COG2081	HI0933 family
DB29_03444	COG1473	amidohydrolase
DB29_03445	COG0432	Pfam Uncharacterised protein family UPF0047
DB29_03446	COG3386	PFAM SMP-30 Gluconolaconase
DB29_03447	COG2244	polysaccharide biosynthetic process
DB29_03448	COG0772	Belongs to the SEDS family
DB29_03449	COG0772	Belongs to the SEDS family
DB29_03450	COG1187	pseudouridine synthase activity
DB29_03451	COG0346	lactoylglutathione lyase activity
DB29_03452	COG0300	oxidoreductase activity
DB29_03453	COG0789	Transcriptional regulator
DB29_03454	COG2207	Transcriptional regulator
DB29_03454	COG3708	Transcriptional regulator
DB29_03455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DB29_03457	COG1380	Effector of murein hydrolase LrgA
DB29_03458	COG1346	cytolysis
DB29_03461	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DB29_03462	COG0022	dehydrogenase e1 component
DB29_03463	COG0508	dehydrogenase complex catalyzes the overall conversion of
DB29_03467	COG0788	formyltetrahydrofolate deformylase activity
DB29_03469	COG0510	thiamine kinase activity
DB29_03471	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DB29_03473	COG1363	Peptidase, m42
DB29_03474	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
DB29_03478	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DB29_03479	COG4848	Belongs to the UPF0354 family
DB29_03480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DB29_03481	COG1674	ftsk spoiiie
DB29_03482	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DB29_03483	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
DB29_03484	COG4980	gas vesicle protein
DB29_03485	COG1605	Chorismate mutase
DB29_03485	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DB29_03487	COG0123	including yeast histone deacetylase and acetoin utilization protein
DB29_03488	COG0517	IMP dehydrogenase activity
DB29_03489	COG0454	-acetyltransferase
DB29_03490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DB29_03491	COG4499	WXG100 protein secretion system (Wss), protein YukC
DB29_03491	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DB29_03492	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DB29_03493	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DB29_03494	COG1956	GAF domain-containing protein
DB29_03496	COG1309	transcriptional regulator
DB29_03497	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DB29_03498	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
DB29_03499	COG1104	cysteine desulfurase activity
DB29_03500	COG0301	tRNA thio-modification
DB29_03502	COG0616	signal peptide processing
DB29_03503	COG1714	RDD family
DB29_03505	COG3874	Sporulation protein YtfJ
DB29_03506	COG2814	Major facilitator Superfamily
DB29_03507	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DB29_03508	COG0827	DNA restriction-modification system
DB29_03509	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DB29_03510	COG3481	metal-dependent phosphohydrolase, HD sub domain
DB29_03512	COG0137	argininosuccinate synthase activity
DB29_03513	COG0165	Argininosuccinate lyase
DB29_03516	COG1028	Short-chain dehydrogenase reductase Sdr
DB29_03518	COG0006	proline dipeptidase activity
DB29_03519	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DB29_03521	COG4109	DRTGG domain
DB29_03523	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DB29_03526	COG0587	DNA-directed DNA polymerase activity
DB29_03527	COG0281	malic enzyme
DB29_03528	COG2186	Transcriptional regulator
DB29_03529	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DB29_03530	COG0825	malonyl-CoA metabolic process
DB29_03531	COG0205	6-phosphofructokinase activity
DB29_03533	COG3030	protein affecting phage T7 exclusion by the F plasmid
DB29_03534	COG2707	UPF0756 membrane protein
DB29_03535	COG0372	Belongs to the citrate synthase family
DB29_03536	COG0538	isocitrate dehydrogenase activity
DB29_03537	COG0039	L-malate dehydrogenase activity
DB29_03538	COG1522	sequence-specific DNA binding
DB29_03539	COG0745	RESPONSE REGULATOR receiver
DB29_03540	COG5002	protein histidine kinase activity
DB29_03541	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DB29_03541	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DB29_03542	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DB29_03543	COG1971	Probably functions as a manganese efflux pump
DB29_03544	COG0237	dephospho-CoA kinase activity
DB29_03545	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DB29_03546	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DB29_03548	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DB29_03549	COG3611	Membrane attachment protein
DB29_03550	COG1484	DNA-dependent DNA replication
DB29_03551	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DB29_03553	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DB29_03556	COG2027	D-alanyl-D-alanine carboxypeptidase
DB29_03559	COG1136	(ABC) transporter
DB29_03560	COG0577	efflux transmembrane transporter activity
DB29_03561	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DB29_03562	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DB29_03563	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DB29_03564	COG3162	membrane
DB29_03565	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DB29_03567	COG1363	Peptidase, m42
DB29_03571	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DB29_03572	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DB29_03573	COG0072	phenylalanine-tRNA ligase activity
DB29_03574	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DB29_03575	COG1286	toxin biosynthetic process
DB29_03576	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DB29_03576	COG1796	DNA polymerase
DB29_03577	COG1193	negative regulation of DNA recombination
DB29_03578	COG3766	membrane
DB29_03579	COG0318	PFAM AMP-dependent synthetase and ligase
DB29_03580	COG1309	transcriptional regulator
DB29_03581	COG1024	Enoyl-CoA hydratase
DB29_03582	COG2086	electron transfer activity
DB29_03583	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DB29_03584	COG3118	belongs to the thioredoxin family
DB29_03585	COG0322	excinuclease ABC activity
DB29_03587	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DB29_03588	COG2009	succinate dehydrogenase
DB29_03589	COG1053	succinate dehydrogenase
DB29_03590	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DB29_03591	COG0824	Thioesterase
DB29_03592	COG2197	response regulator
DB29_03593	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DB29_03594	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DB29_03595	COG1846	Transcriptional regulator
DB29_03596	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DB29_03599	COG5401	PFAM Sporulation and spore germination
DB29_03600	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DB29_03601	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DB29_03602	COG0622	Phosphoesterase
DB29_03603	COG2132	Multicopper oxidase
DB29_03606	COG0129	dihydroxy-acid dehydratase activity
DB29_03608	COG0028	Belongs to the TPP enzyme family
DB29_03609	COG0440	acetolactate synthase activity
DB29_03610	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DB29_03611	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DB29_03612	COG0473	3-isopropylmalate dehydrogenase activity
DB29_03613	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DB29_03614	COG0066	3-isopropylmalate dehydratase activity
DB29_03615	COG1477	protein flavinylation
DB29_03615	COG0457	Tetratricopeptide repeat
DB29_03616	COG0544	peptidyl-prolyl cis-trans isomerase activity
DB29_03617	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DB29_03618	COG0470	DNA polymerase III
DB29_03618	COG1067	ATP-dependent peptidase activity
DB29_03619	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DB29_03620	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DB29_03621	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DB29_03622	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DB29_03623	COG0181	hydroxymethylbilane synthase activity
DB29_03625	COG0113	porphobilinogen synthase activity
DB29_03626	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DB29_03627	COG1388	LysM domain
DB29_03627	COG1388	LysM domain
DB29_03632	COG0525	valine-tRNA ligase activity
DB29_03633	COG0285	dihydrofolate synthase activity
DB29_03634	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DB29_03636	COG1506	peptidase
DB29_03636	COG4946	Tricorn protease homolog
DB29_03636	COG0823	Involved in the tonB-independent uptake of proteins
DB29_03637	COG0424	maF-like protein
DB29_03638	COG2003	Belongs to the UPF0758 family
DB29_03639	COG1077	Cell shape determining protein MreB Mrl
DB29_03640	COG1792	Involved in formation and maintenance of cell shape
DB29_03641	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DB29_03642	COG0850	regulation of cytokinetic process
DB29_03643	COG2894	cell division
DB29_03644	COG0693	protein deglycase activity
DB29_03645	COG0315	cyclic pyranopterin monophosphate synthase activity
DB29_03646	COG1268	BioY protein
DB29_03647	COG0667	Aldo Keto reductase
DB29_03648	COG0739	heme binding
DB29_03649	COG1994	Peptidase M50
DB29_03650	COG1530	ribonuclease E activity
DB29_03651	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DB29_03652	COG2868	ribosomal protein
DB29_03653	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DB29_03654	COG2002	toxin-antitoxin pair type II binding
DB29_03655	COG1228	amidohydrolase
DB29_03657	COG1573	uracil-dna glycosylase
DB29_03658	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DB29_03659	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DB29_03661	COG2318	DinB family
DB29_03663	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DB29_03664	COG0573	inorganic phosphate transmembrane transporter activity
DB29_03665	COG0581	inorganic phosphate transmembrane transporter activity
DB29_03666	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DB29_03667	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DB29_03671	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DB29_03673	COG2198	Histidine kinase
DB29_03673	COG0643	Histidine kinase
DB29_03674	COG0835	chemotaxis
DB29_03675	COG0367	asparagine synthase
DB29_03681	COG1834	amidinotransferase
DB29_03682	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DB29_03684	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DB29_03684	COG0425	Belongs to the sulfur carrier protein TusA family
DB29_03686	COG1073	alpha beta
DB29_03687	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DB29_03690	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DB29_03695	COG0561	phosphatase activity
DB29_03696	COG3336	cytochrome c oxidase
DB29_03697	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DB29_03698	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DB29_03699	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DB29_03700	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DB29_03701	COG0505	Belongs to the CarA family
DB29_03702	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DB29_03703	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DB29_03704	COG2267	carboxylic ester hydrolase activity
DB29_03707	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DB29_03710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DB29_03711	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DB29_03714	COG0617	tRNA 3'-terminal CCA addition
DB29_03716	COG3409	Peptidoglycan-binding domain 1 protein
DB29_03716	COG3773	Cell wall hydrolase
DB29_03717	COG2340	Cysteine-rich secretory protein family
DB29_03718	COG1072	(Pantothenic acid kinase))
DB29_03719	COG2357	RelA SpoT domain protein
DB29_03720	COG5504	Zn-dependent protease
DB29_03723	COG0180	Tryptophanyl-tRNA synthetase
DB29_03726	COG1418	mRNA catabolic process
DB29_03727	COG1272	protein, Hemolysin III
DB29_03730	COG0456	acetyltransferase
DB29_03732	COG1393	Belongs to the ArsC family
DB29_03737	COG2346	COG2346, Truncated hemoglobins
DB29_03739	COG0741	lytic transglycosylase activity
DB29_03740	COG4116	CYTH
DB29_03742	COG2357	RelA SpoT domain protein
DB29_03743	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DB29_03744	COG0564	pseudouridine synthase activity
DB29_03747	COG2226	methyltransferase
DB29_03756	COG0210	DNA helicase
DB29_03757	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DB29_03759	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DB29_03760	COG4537	Required for transformation and DNA binding
DB29_03767	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DB29_03770	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DB29_03771	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DB29_03772	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DB29_03773	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DB29_03774	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DB29_03775	COG0095	Lipoate-protein ligase
DB29_03776	COG3973	AAA domain
DB29_03777	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DB29_03778	COG1533	DNA photolyase activity
DB29_03779	COG1321	iron dependent repressor
DB29_03780	COG1752	Esterase of the alpha-beta hydrolase superfamily
DB29_03783	COG0006	proline dipeptidase activity
DB29_03784	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DB29_03785	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DB29_03789	COG3854	ATPases associated with a variety of cellular activities
DB29_03798	COG0511	ligase activity, forming carbon-carbon bonds
DB29_03799	COG0439	Biotin carboxylase
DB29_03800	COG1302	Protein conserved in bacteria
DB29_03801	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DB29_03802	COG1570	exodeoxyribonuclease VII activity
DB29_03803	COG1722	exodeoxyribonuclease VII activity
DB29_03804	COG0142	geranyltranstransferase activity
DB29_03805	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DB29_03806	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DB29_03808	COG1438	arginine binding
DB29_03809	COG0497	DNA recombination
DB29_03810	COG0750	zinc metalloprotease
DB29_03811	COG0745	RESPONSE REGULATOR receiver
DB29_03815	COG3829	transcription factor binding
DB29_03815	COG3290	protein histidine kinase activity
DB29_03817	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DB29_03818	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DB29_03819	COG0022	dehydrogenase e1 component
DB29_03820	COG0508	dehydrogenase complex catalyzes the overall conversion of
DB29_03823	COG0561	phosphatase activity
DB29_03825	COG1937	Protein conserved in bacteria
DB29_03826	COG2608	mercury ion transmembrane transporter activity
DB29_03828	COG1902	pentaerythritol trinitrate reductase activity
DB29_03830	COG0702	epimerase
DB29_03834	COG0668	transmembrane transport
DB29_03837	COG2171	N-acyltransferase activity
DB29_03838	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DB29_03839	COG1473	amidohydrolase
DB29_03841	COG0668	transmembrane transport
DB29_03842	COG0450	alkyl hydroperoxide reductase
DB29_03843	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DB29_03844	COG0569	domain protein
DB29_03845	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DB29_03847	COG0242	peptide deformylase activity
DB29_03851	COG0022	dehydrogenase e1 component
DB29_03852	COG0508	dehydrogenase complex catalyzes the overall conversion of
DB29_03854	COG0444	Belongs to the ABC transporter superfamily
DB29_03855	COG4608	Belongs to the ABC transporter superfamily
DB29_03857	COG0601	transmembrane transport
DB29_03858	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DB29_03860	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DB29_03865	COG1982	Orn Lys Arg decarboxylase major
DB29_03867	COG4493	Belongs to the UPF0637 family
DB29_03868	COG0483	inositol monophosphate 1-phosphatase activity
DB29_03873	COG4896	Protein conserved in bacteria
DB29_03874	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DB29_03875	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DB29_03876	COG4838	Belongs to the UPF0358 family
DB29_03877	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DB29_03878	COG1612	heme a metabolic process
DB29_03886	COG2340	Cysteine-rich secretory protein family
DB29_03893	COG4471	UPF0298 protein
DB29_03895	COG0742	ribosomal rna small subunit methyltransferase
DB29_03896	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DB29_03897	COG3314	Sporulation integral membrane protein YlbJ
DB29_03898	COG1752	Esterase of the alpha-beta hydrolase superfamily
DB29_03899	COG3480	Lon protease (S16) C-terminal proteolytic domain
DB29_03900	COG1323	Belongs to the UPF0348 family
DB29_03901	COG1399	metal-binding, possibly nucleic acid-binding protein
DB29_03903	COG0454	-acetyltransferase
DB29_03904	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DB29_03906	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
DB29_03907	COG2001	Belongs to the MraZ family
DB29_03908	COG0275	rRNA processing
DB29_03909	COG4839	cell division protein FtsL
DB29_03911	COG0768	penicillin binding
DB29_03912	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DB29_03913	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DB29_03914	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DB29_03915	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DB29_03917	COG0772	Belongs to the SEDS family
DB29_03918	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DB29_03919	COG0849	cell division
DB29_03920	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DB29_03922	COG1191	sigma factor activity
DB29_03923	COG1191	sigma factor activity
DB29_03924	COG1873	PFAM PRC-barrel domain
DB29_03926	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DB29_03927	COG1799	cell septum assembly
DB29_03928	COG0762	integral membrane protein
DB29_03929	COG2302	S4 RNA-binding domain
DB29_03930	COG3599	regulation of cell shape
DB29_03931	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DB29_03932	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DB29_03933	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DB29_03934	COG0564	pseudouridine synthase activity
DB29_03935	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DB29_03936	COG2233	PERMEase
DB29_03937	COG0540	Belongs to the ATCase OTCase family
DB29_03938	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DB29_03939	COG0505	Belongs to the CarA family
DB29_03940	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DB29_03941	COG0543	2 iron, 2 sulfur cluster binding
DB29_03942	COG0167	dihydroorotate dehydrogenase activity
DB29_03943	COG0284	orotidine-5'-phosphate decarboxylase activity
DB29_03944	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DB29_03947	COG4485	Bacterial membrane protein, YfhO
DB29_03949	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DB29_03951	COG2052	Domain of unknown function (DUF370)
DB29_03952	COG0194	GDP metabolic process
DB29_03953	COG1758	RNA polymerase activity
DB29_03954	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DB29_03955	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DB29_03956	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DB29_03957	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DB29_03957	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DB29_03958	COG0631	protein serine/threonine phosphatase activity
DB29_03959	COG0515	serine threonine protein kinase
DB29_03959	COG2815	serine threonine protein kinase
DB29_03960	COG1162	GTPase activity
DB29_03961	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DB29_03963	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DB29_03964	COG1302	Protein conserved in bacteria
DB29_03965	COG1461	Dihydroxyacetone kinase
DB29_03966	COG1307	EDD domain protein, DegV family
DB29_03967	COG1760	l-serine dehydratase
DB29_03968	COG1760	l-serine dehydratase
DB29_03969	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DB29_03970	COG1349	DNA-binding transcription factor activity
DB29_03971	COG0416	fatty acid biosynthetic process
DB29_03972	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DB29_03973	COG1028	Short-chain dehydrogenase reductase Sdr
DB29_03974	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DB29_03975	COG0571	ribonuclease III activity
DB29_03977	COG1196	nuclear chromosome segregation
DB29_03978	COG1196	nuclear chromosome segregation
DB29_03979	COG0552	protein localization to endoplasmic reticulum
DB29_03980	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DB29_03981	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DB29_03982	COG0228	four-way junction DNA binding
DB29_03983	COG1837	Belongs to the UPF0109 family
DB29_03985	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DB29_03986	COG0336	Belongs to the RNA methyltransferase TrmD family
DB29_03987	COG0018	arginyl-trna synthetase
DB29_03988	COG0335	large ribosomal subunit rRNA binding
DB29_03993	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DB29_03996	COG0045	succinate-CoA ligase (ADP-forming) activity
DB29_03997	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DB29_03998	COG0758	DNA mediated transformation
DB29_03999	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DB29_04000	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DB29_04001	COG4974	Belongs to the 'phage' integrase family
DB29_04002	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DB29_04003	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DB29_04004	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DB29_04005	COG1815	bacterial-type flagellum-dependent cell motility
DB29_04006	COG1558	bacterial-type flagellum-dependent cell motility
DB29_04007	COG1677	Flagellar hook-basal body complex protein FliE
DB29_04008	COG1766	The M ring may be actively involved in energy transduction
DB29_04009	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DB29_04010	COG1317	bacterial-type flagellum organization
DB29_04011	COG1157	protein secretion by the type III secretion system
DB29_04015	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DB29_04016	COG4786	Flagellar basal body rod
DB29_04019	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DB29_04020	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DB29_04020	COG1776	CheC inhibitor of MCP methylation
DB29_04021	COG2201	protein-glutamate methylesterase activity
DB29_04022	COG3190	flagellar
DB29_04023	COG1338	Plays a role in the flagellum-specific transport system
DB29_04024	COG1987	bacterial-type flagellum assembly
DB29_04025	COG1684	flagellar biosynthetic protein fliR
DB29_04026	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DB29_04027	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DB29_04028	COG1419	protein localization to endoplasmic reticulum
DB29_04030	COG2201	protein-glutamate methylesterase activity
DB29_04032	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DB29_04033	COG1191	sigma factor activity
DB29_04035	COG0052	Belongs to the universal ribosomal protein uS2 family
DB29_04036	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DB29_04037	COG0528	UMP kinase activity
DB29_04038	COG0233	cytoplasmic translational termination
DB29_04039	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DB29_04040	COG4589	Belongs to the CDS family
DB29_04041	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DB29_04042	COG0750	zinc metalloprotease
DB29_04043	COG0442	prolyl-tRNA aminoacylation
DB29_04044	COG2176	DNA-directed DNA polymerase activity
DB29_04045	COG0779	Required for maturation of 30S ribosomal subunits
DB29_04046	COG0195	Participates in both transcription termination and antitermination
DB29_04047	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DB29_04048	COG1358	cellular component organization or biogenesis
DB29_04049	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DB29_04051	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DB29_04052	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DB29_04053	COG0196	riboflavin kinase activity
DB29_04055	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DB29_04056	COG1185	polyribonucleotide nucleotidyltransferase activity
DB29_04057	COG0726	polysaccharide deacetylase
DB29_04058	COG0612	Peptidase, M16
DB29_04060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DB29_04061	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DB29_04062	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DB29_04063	COG0527	aspartate kinase activity
DB29_04064	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DB29_04065	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DB29_04066	COG0740	serine-type endopeptidase activity
DB29_04068	COG1674	ftsk spoiiie
DB29_04069	COG2188	Transcriptional regulator
DB29_04070	COG0612	Peptidase, M16
DB29_04071	COG0612	Peptidase, M16
DB29_04072	COG0300	oxidoreductase activity
DB29_04075	COG1426	Protein conserved in bacteria
DB29_04076	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DB29_04077	COG1546	Belongs to the CinA family
DB29_04077	COG1058	Belongs to the CinA family
DB29_04078	COG0513	Belongs to the DEAD box helicase family
DB29_04079	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DB29_04084	COG1418	mRNA catabolic process
DB29_04085	COG1692	metallophosphoesterase
DB29_04086	COG2359	stage V sporulation protein S
DB29_04088	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DB29_04089	COG4550	Control of competence regulator ComK, YlbF/YmcA
DB29_04091	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DB29_04092	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DB29_04093	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DB29_04095	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DB29_04096	COG1923	regulation of RNA biosynthetic process
DB29_04099	COG0464	growth
DB29_04100	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DB29_04101	COG0174	glutamine synthetase
DB29_04104	COG0277	FAD linked oxidase domain protein
DB29_04105	COG0247	lactate metabolic process
DB29_04106	COG0277	FAD linked oxidase domain protein
DB29_04107	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DB29_04108	COG0179	Fumarylacetoacetate (FAA) hydrolase
DB29_04109	COG1414	Transcriptional regulator
DB29_04112	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DB29_04113	COG2814	Major facilitator Superfamily
DB29_04114	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DB29_04116	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DB29_04118	COG4224	UPF0291 protein
DB29_04119	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DB29_04121	COG3763	UPF0154 protein
DB29_04122	COG1132	(ABC) transporter
DB29_04123	COG1132	(ABC) transporter
DB29_04127	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DB29_04134	COG0464	growth
DB29_04135	COG0824	Thioesterase
DB29_04136	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DB29_04140	COG2200	EAL domain
DB29_04145	COG0835	chemotaxis
DB29_04145	COG0784	Response regulator, receiver
DB29_04147	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DB29_04151	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DB29_04153	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DB29_04155	COG1254	Belongs to the acylphosphatase family
DB29_04156	COG1115	amino acid carrier protein
DB29_04157	COG2309	aminopeptidase activity
DB29_04158	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DB29_04159	COG0720	synthase
DB29_04160	COG0602	queuosine metabolic process
DB29_04161	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DB29_04162	COG2197	response regulator
DB29_04163	COG4585	Histidine kinase
DB29_04167	COG1131	(ABC) transporter
DB29_04169	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DB29_04169	COG0551	DNA topoisomerase type I activity
DB29_04170	COG1764	response to oxidative stress
DB29_04175	COG0567	Dehydrogenase, E1 component
DB29_04176	COG0508	dehydrogenase complex catalyzes the overall conversion of
DB29_04178	COG0488	(ABC) transporter
DB29_04179	COG0656	L-ascorbic acid biosynthetic process
DB29_04180	COG0514	ATP-dependent DNA helicase (RecQ)
DB29_04185	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DB29_04186	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DB29_04187	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DB29_04188	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DB29_04190	COG4876	unkown
DB29_04192	COG1960	acyl-CoA dehydrogenase activity
DB29_04193	COG3069	C4-dicarboxylate transmembrane transporter activity
DB29_04195	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DB29_04198	COG1396	sequence-specific DNA binding
DB29_04210	COG0629	single-stranded DNA binding
DB29_04212	COG3331	DNA recombination
DB29_04217	COG1595	DNA-templated transcription, initiation
DB29_04218	COG0758	DNA mediated transformation
DB29_04221	COG3728	DNA packaging
DB29_04221	COG5484	DNA packaging
DB29_04265	COG0438	transferase activity, transferring glycosyl groups
DB29_04268	COG0561	phosphatase activity
DB29_04269	COG1263	PTS System
DB29_04269	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DB29_04270	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DB29_04278	COG1263	PTS System
DB29_04278	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DB29_04279	COG3394	polysaccharide catabolic process
DB29_04280	COG1486	melibiose metabolic process
DB29_04281	COG2188	Transcriptional regulator
DB29_04285	COG0860	N-Acetylmuramoyl-L-alanine amidase
DB29_04285	COG2247	cell wall binding repeat
DB29_04290	COG0438	transferase activity, transferring glycosyl groups
DB29_04293	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DB29_04294	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DB29_04295	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DB29_04297	COG1199	ATP-dependent helicase activity
DB29_04297	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DB29_04298	COG0402	S-adenosylhomocysteine deaminase activity
DB29_04302	COG0017	Asparaginyl-tRNA synthetase
DB29_04303	COG3935	DnaD domain protein
DB29_04304	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DB29_04305	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DB29_04307	COG1943	Transposase
DB29_04308	COG4499	WXG100 protein secretion system (Wss), protein YukC
DB29_04308	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DB29_04309	COG3331	DNA recombination
DB29_04312	COG0789	Transcriptional regulator
DB29_04315	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DB29_04316	COG0693	protein deglycase activity
DB29_04317	COG1234	tRNA 3'-trailer cleavage
DB29_04322	COG1413	lyase activity
DB29_04324	COG3402	PFAM membrane-flanked domain
DB29_04325	COG3428	Bacterial PH domain
DB29_04330	COG0067	glutamate synthase
DB29_04330	COG0070	glutamate synthase
DB29_04330	COG0069	glutamate synthase activity
DB29_04331	COG0493	'glutamate synthase
DB29_04340	COG0561	phosphatase activity
DB29_04342	COG0346	lactoylglutathione lyase activity
DB29_04343	COG0400	carboxylic ester hydrolase activity
DB29_04346	COG0814	amino acid
DB29_04347	COG0697	spore germination
DB29_04349	COG1111	helicase
DB29_04349	COG1205	dead DEAH box helicase
DB29_04350	COG3359	exonuclease
DB29_04352	COG4474	Belongs to the UPF0398 family
DB29_04353	COG3599	regulation of cell shape
DB29_04354	COG0328	RNA-DNA hybrid ribonuclease activity
DB29_04360	COG1070	Carbohydrate kinase
DB29_04366	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DB29_04368	COG1028	Short-chain dehydrogenase reductase Sdr
DB29_04369	COG0517	IMP dehydrogenase activity
DB29_04369	COG1125	glycine betaine transport
DB29_04371	COG1832	CoA-binding protein
DB29_04372	COG0187	DNA topoisomerase II activity
DB29_04373	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DB29_04376	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DB29_04377	COG0628	permease
DB29_04378	COG1360	Flagellar Motor Protein
DB29_04379	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DB29_04380	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DB29_04383	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
DB29_0P0003	COG3883	PFAM NLP P60 protein
DB29_0P0003	COG0791	NLP P60 protein
DB29_0P0020	COG2003	Belongs to the UPF0758 family