locus-tag class description BIZ35_00010 ENOG4105DXD 2-methylcitrate dehydratase BIZ35_00015 ENOG4105CR4 methylisocitrate lyase BIZ35_00025 ENOG4105DV0 amidase (EC 3.5.1.4 BIZ35_00035 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BIZ35_00040 ENOG4107Z6I Thiamine biosynthesis protein BIZ35_00050 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BIZ35_00055 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) BIZ35_00060 ENOG4105D6E homoserine dehydrogenase BIZ35_00075 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) BIZ35_00080 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BIZ35_00090 ENOG4108IA2 Sodium pantothenate symporter BIZ35_00130 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BIZ35_00150 ENOG4105CSU acyl-Coa dehydrogenase BIZ35_00155 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BIZ35_00160 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BIZ35_00170 ENOG4107YZX Universal stress protein BIZ35_00195 ENOG4105PGZ NB-ARC domain BIZ35_00225 ENOG4108X4Q Hydrolase BIZ35_00265 ENOG4107V0Z fmn reductase BIZ35_00270 ENOG4107VRP DNA repair exonuclease BIZ35_00275 ENOG4106D4I domain protein BIZ35_00280 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BIZ35_00285 ENOG4105UQX Mate efflux family protein BIZ35_00320 ENOG4105JSC dimethylmenaquinone methyltransferase BIZ35_00330 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BIZ35_00335 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BIZ35_00340 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BIZ35_00355 ENOG4105ETU transcriptional activator (TenA BIZ35_00390 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BIZ35_00395 ENOG4105C85 amino acid BIZ35_00400 ENOG4105C0R drug resistance transporter emrb qaca subfamily BIZ35_00415 ENOG4105EYF MMPL domain protein BIZ35_00425 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BIZ35_00440 ENOG4105FDT acyl-CoA dehydrogenase BIZ35_00450 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BIZ35_00455 ENOG4105CMR udp-glucose 4-epimerase BIZ35_00460 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase BIZ35_00470 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) BIZ35_00490 ENOG4105QNR S1 RNA binding domain protein BIZ35_00495 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BIZ35_00500 ENOG4105DG6 mannose-6-phosphate isomerase BIZ35_00505 ENOG4105CVG Homoserine O-transsuccinylase BIZ35_00510 ENOG4105C0R drug resistance transporter emrb qaca subfamily BIZ35_00515 ENOG4105CE4 GlcNAc 6-P deacetylase BIZ35_00525 ENOG4105FDP GntR family transcriptional regulator BIZ35_00535 ENOG4107SDU Methyl-accepting chemotaxis BIZ35_00540 ENOG4107RVG penicillin-binding protein BIZ35_00545 ENOG4105ESV Glycosyl transferase, family 4 BIZ35_00550 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BIZ35_00560 ENOG4105WH1 Two component transcriptional regulator luxr family BIZ35_00570 ENOG4105CUB amino acid BIZ35_00585 ENOG4105MJ2 Competence protein BIZ35_00605 ENOG4105E1Q flagellar hook-associated protein BIZ35_00610 ENOG4105DTJ flagellar hook-associated protein BIZ35_00615 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) BIZ35_00620 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) BIZ35_00630 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BIZ35_00640 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BIZ35_00645 ENOG4105KT7 mgtC SapB transporter BIZ35_00650 ENOG4105D4U had-superfamily hydrolase, subfamily iia BIZ35_00660 ENOG4105C54 Major Facilitator superfamily BIZ35_00675 ENOG4105C85 amino acid BIZ35_00690 ENOG4105DAN ATP-dependent protease BIZ35_00700 ENOG4108VX5 3-methyladenine DNA glycosylase BIZ35_00715 ENOG41083S7 flagellar protein FlaG BIZ35_00720 ENOG4107RT6 flagellar hook-associated BIZ35_00725 ENOG4105MQ3 flagellar protein FliS BIZ35_00740 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BIZ35_00745 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BIZ35_00750 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BIZ35_00765 ENOG4105CAK Cell division ATP-binding protein ftsE BIZ35_00770 ENOG4105CRP Part of the ABC transporter FtsEX involved in BIZ35_00775 ENOG4105DR5 peptidase BIZ35_00790 ENOG4105D6E homoserine dehydrogenase BIZ35_00795 ENOG4105CN1 protease BIZ35_00810 ENOG4105DHS permease protein BIZ35_00815 ENOG4105CM4 permease protein BIZ35_00820 ENOG4108IPW abc transporter atp-binding protein BIZ35_00840 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BIZ35_00845 ENOG4105BZU Histidine kinase BIZ35_00850 ENOG4105C1Q protoporphyrinogen oxidase BIZ35_00855 ENOG4105CVA phosphate BIZ35_00865 ENOG4105C8U phosphate abc transporter BIZ35_00870 ENOG4105E2Z phosphate ABC transporter (Permease BIZ35_00880 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BIZ35_00890 ENOG410838F Glycosyl transferase family 2 BIZ35_00925 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BIZ35_00930 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BIZ35_00935 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase BIZ35_00955 ENOG4107SJB teichoic acid biosynthesis BIZ35_00960 ENOG4107SJB teichoic acid biosynthesis BIZ35_00970 ENOG4107SJB teichoic acid biosynthesis BIZ35_00975 ENOG4108PY7 BIZ35_00985 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) BIZ35_00995 ENOG4107XGZ Hydrolase BIZ35_01000 ENOG4108S4C acetyltransferase BIZ35_01010 ENOG4105C3M thioredoxin reductase BIZ35_01020 ENOG4108Z4K mutator MutT protein BIZ35_01025 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BIZ35_01030 ENOG4105CHW UPF0052 protein BIZ35_01040 ENOG4105KRI phosphocarrier protein (HPr BIZ35_01045 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BIZ35_01065 ENOG4105C9Q fumarate hydratase class II BIZ35_01070 ENOG4105YWU small acid-soluble spore protein BIZ35_01090 ENOG410839P BIZ35_01110 ENOG4108UH6 UPF0754 membrane protein BIZ35_01125 ENOG4105CGU Enoyl-CoA hydratase BIZ35_01135 ENOG4108ZCF integral membrane protein BIZ35_01140 ENOG4108PJD permease BIZ35_01150 ENOG4107VRP DNA repair exonuclease BIZ35_01155 ENOG4106D4I domain protein BIZ35_01160 ENOG4105EQI Metal Dependent Phosphohydrolase BIZ35_01170 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BIZ35_01205 ENOG4105NBU tryptophan transport protein BIZ35_01210 ENOG4105K59 histidine triad (HIT) protein BIZ35_01235 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BIZ35_01240 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BIZ35_01245 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BIZ35_01250 ENOG4105C1Q protoporphyrinogen oxidase BIZ35_01260 ENOG4105ECB domain protein BIZ35_01265 ENOG4105C5Y PTS System BIZ35_01265 ENOG4105C5Y PTS System BIZ35_01270 ENOG4105E98 transcriptional regulator DeoR family BIZ35_01280 ENOG4108TVT permease BIZ35_01285 ENOG4105C26 Dehydrogenase BIZ35_01290 ENOG4108KF3 Electron transport protein SCO1 SenC BIZ35_01300 ENOG4106AXD BIZ35_01305 ENOG4105DF9 Lipoate-protein, ligase BIZ35_01310 ENOG4105CEY Amp-dependent synthetase and ligase BIZ35_01320 ENOG4108UMN azlc family BIZ35_01330 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BIZ35_01355 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination BIZ35_01360 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BIZ35_01395 ENOG4105DHF Membrane BIZ35_01400 ENOG4105ERH Fumarylacetoacetate hydrolase BIZ35_01420 ENOG4105EPR degv family BIZ35_01425 ENOG41073B9 BIZ35_01430 ENOG4108KP7 hydrolase BIZ35_01435 ENOG4105VG1 fes assembly suf system protein BIZ35_01465 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BIZ35_01470 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BIZ35_01485 ENOG4108JQ7 (ABC) transporter BIZ35_01490 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BIZ35_01500 ENOG4105HJK ABC transporter BIZ35_01515 ENOG4105C31 Tryptophanyl-tRNA synthetase BIZ35_01530 ENOG4108J59 Extracellular solute-binding protein, family 5 BIZ35_01535 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BIZ35_01540 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BIZ35_01550 ENOG4108JQ7 (ABC) transporter BIZ35_01555 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) BIZ35_01575 ENOG4105DPN Oligoendopeptidase f BIZ35_01585 ENOG4105T58 Dithiol-disulfide isomerase BIZ35_01590 ENOG4108Z18 K06886 hemoglobin BIZ35_01595 ENOG4105E4C Lytic transglycosylase catalytic BIZ35_01600 ENOG4105MIX Adenylate cyclase BIZ35_01615 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BIZ35_01620 ENOG4105EMS pseudouridine synthase BIZ35_01625 ENOG4107S1Q Phosphatase BIZ35_01630 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH BIZ35_01660 ENOG41090VF Stage v sporulation protein ac BIZ35_01665 ENOG4105CZ3 stage V sporulation protein ad BIZ35_01690 ENOG4108ZMI UPF0477 protein BIZ35_01710 ENOG4105EVU fructokinase BIZ35_01720 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BIZ35_01725 ENOG4108IUX (ABC) transporter BIZ35_01730 ENOG4105RHA ABC transporter, permease BIZ35_01745 ENOG4105CTZ aminopeptidase c BIZ35_01755 ENOG4105DPN Oligoendopeptidase f BIZ35_01810 ENOG4108Z7F N-acetyltransferase BIZ35_01830 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BIZ35_01835 ENOG4105FGV Chromate BIZ35_01840 ENOG4105CAH Chromate BIZ35_01855 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BIZ35_01860 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BIZ35_01970 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BIZ35_01980 ENOG4107XVH Transcriptional regulator BIZ35_01985 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BIZ35_02015 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BIZ35_02055 ENOG4105HUF DNA protection during starvation protein BIZ35_02065 ENOG4105EE0 oxidoreductase BIZ35_02070 ENOG4105BZU Histidine kinase BIZ35_02075 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) BIZ35_02085 ENOG4107TS3 membrane protein, TerC BIZ35_02090 ENOG410681C small acid-soluble spore protein BIZ35_02095 ENOG4105BZU Histidine kinase BIZ35_02100 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BIZ35_02125 ENOG4108K88 Membrane BIZ35_02150 ENOG4105KRI phosphocarrier protein (HPr BIZ35_02155 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BIZ35_02165 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr BIZ35_02170 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BIZ35_02175 ENOG4105CHM Aminotransferase BIZ35_02180 ENOG4107R88 Chemotaxis protein (CheV) BIZ35_02185 ENOG4105UIN BIZ35_02190 ENOG4105EYF MMPL domain protein BIZ35_02200 ENOG4105BZU Histidine kinase BIZ35_02210 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BIZ35_02220 ENOG4107IN1 Protein of unknown function (DUF1797) BIZ35_02235 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) BIZ35_02240 ENOG4105CH2 amidohydrolase BIZ35_02250 ENOG4105CN5 Metallo-Beta-Lactamase BIZ35_02255 ENOG4106148 UPF0356 protein BIZ35_02290 ENOG4105CXN decarboxylase BIZ35_02295 ENOG4105WBI UPF0223 protein BIZ35_02310 ENOG4105ECY inositol monophosphatase BIZ35_02320 ENOG4105CI3 gtp-binding protein typa BIZ35_02325 ENOG4105QA2 BIZ35_02330 ENOG4108IAB Phoh family BIZ35_02345 ENOG4105CNI cell division protein FtsW BIZ35_02355 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BIZ35_02375 ENOG41064X9 cytochrome C oxidase subunit IV BIZ35_02390 ENOG4106UY4 Inherit from COG: Scp-like extracellular BIZ35_02395 ENOG4108VUY thioesterase Superfamily protein BIZ35_02420 ENOG4105WUC UPF0298 protein BIZ35_02430 ENOG4106H78 methyltransferase BIZ35_02435 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BIZ35_02440 ENOG4105H20 Sporulation integral membrane protein YlbJ BIZ35_02445 ENOG4105D78 K07001 NTE family protein BIZ35_02450 ENOG41063PX domain protein BIZ35_02455 ENOG4105CDE UPF0348 protein BIZ35_02460 ENOG4105KNH Nucleic acid-binding protein BIZ35_02465 ENOG41067VY 50S ribosomal protein L32 BIZ35_02475 ENOG4108YG3 N-acetyltransferase BIZ35_02480 ENOG4107S3C Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BIZ35_02485 ENOG41074B2 UPF0747 protein BIZ35_02490 ENOG4108V6E Cell division protein mraZ BIZ35_02495 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) BIZ35_02500 ENOG41068DC Essential cell division protein (By similarity) BIZ35_02505 ENOG4105CJN penicillin-binding protein BIZ35_02510 ENOG4105CJN penicillin-binding protein BIZ35_02515 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BIZ35_02525 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BIZ35_02530 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) BIZ35_02535 ENOG4105CNI cell division protein FtsW BIZ35_02540 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BIZ35_02545 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BIZ35_02550 ENOG4105D5G Transposase BIZ35_02555 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BIZ35_02560 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BIZ35_02565 ENOG4108AWX Sporulation factor SpoIIGA BIZ35_02570 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BIZ35_02580 ENOG4105WR5 sporulation protein, YlmC YmxH family BIZ35_02585 ENOG41069ER domain protein BIZ35_02595 ENOG4105DFA alanine racemase domain protein BIZ35_02600 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) BIZ35_02605 ENOG41067XK integral membrane protein BIZ35_02610 ENOG4105DBK s4 domain protein BIZ35_02640 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BIZ35_02645 ENOG4105C34 Pseudouridine synthase BIZ35_02650 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) BIZ35_02655 ENOG4105CXT aspartate transcarbamylase BIZ35_02660 ENOG4105CD3 dihydroorotase BIZ35_02680 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) BIZ35_02685 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) BIZ35_02690 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BIZ35_02705 ENOG4106AXJ AraC family transcriptional regulator BIZ35_02710 ENOG4105DET Rhamnulokinase BIZ35_02715 ENOG4105DKG l-rhamnose isomerase BIZ35_02720 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) BIZ35_02725 ENOG4105C0A alcohol dehydrogenase BIZ35_02730 ENOG4108Z5K methylglyoxal synthase BIZ35_02735 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BIZ35_02740 ENOG4105C0R drug resistance transporter emrb qaca subfamily BIZ35_02745 ENOG4105C0R drug resistance transporter emrb qaca subfamily BIZ35_02750 ENOG4105J7D transcriptional regulator BIZ35_02760 ENOG4105C02 permease BIZ35_02765 ENOG410667J hydrolase BIZ35_02775 ENOG4105CT4 transporter BIZ35_02790 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BIZ35_02795 ENOG4105C09 Bile acid BIZ35_02805 ENOG4105F23 Fibronectin-binding protein BIZ35_02815 ENOG4105DSJ YicC domain protein BIZ35_02820 ENOG4105KC4 UPF0296 protein BIZ35_02825 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BIZ35_02835 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BIZ35_02840 ENOG4105C25 Primosomal protein n' BIZ35_02845 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BIZ35_02850 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BIZ35_02855 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BIZ35_02860 ENOG4108ZF3 Phosphatase BIZ35_02865 ENOG4105D9P serine threonine protein kinase BIZ35_02870 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BIZ35_02875 ENOG4105DJV ribulose-phosphate 3-epimerase BIZ35_02880 ENOG4105FJ0 thiamine BIZ35_02890 ENOG4105VB9 50S ribosomal protein l28 BIZ35_02900 ENOG4108ZAA Alkaline-shock protein BIZ35_02905 ENOG4105DP4 dak2 domain fusion protein ylov BIZ35_02915 ENOG4105EJQ L-serine dehydratase BIZ35_02920 ENOG4105CB5 ATP-dependent DNA helicase recG BIZ35_02925 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) BIZ35_02930 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) BIZ35_02935 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BIZ35_02940 ENOG4105CHR reductase BIZ35_02945 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BIZ35_02950 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BIZ35_02955 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BIZ35_02960 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BIZ35_02975 ENOG4105K5M 30s ribosomal protein S16 BIZ35_02980 ENOG4108BW8 UPF0109 protein BIZ35_02990 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) BIZ35_02995 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) BIZ35_03000 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BIZ35_03010 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BIZ35_03025 ENOG4105D00 flagellar biosynthetic protein flhB BIZ35_03030 ENOG4105CMV Succinyl-CoA synthetase subunit beta BIZ35_03035 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BIZ35_03040 ENOG4105C79 DNA protecting protein DprA BIZ35_03045 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BIZ35_03055 ENOG4108HE4 integrase family BIZ35_03060 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) BIZ35_03065 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) BIZ35_03070 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) BIZ35_03075 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BIZ35_03080 ENOG4108ZC9 flagellar basal-body rod protein flgc BIZ35_03085 ENOG4105VQ0 flagellar hook-basal body complex protein fliE BIZ35_03090 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) BIZ35_03095 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BIZ35_03110 ENOG4106YF4 Flagellar biosynthesis chaperone BIZ35_03125 ENOG410822I Flagellar hook capping protein BIZ35_03135 ENOG4108JQA flagellar BIZ35_03150 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BIZ35_03155 ENOG4105DD5 Flagellar motor switch protein BIZ35_03160 ENOG4107YTP response regulator receiver protein BIZ35_03170 ENOG4105CN7 Flagellar biosynthetic protein FliP BIZ35_03175 ENOG4105VS8 Flagellar biosynthetic protein fliq BIZ35_03180 ENOG4105D19 Role in flagellar biosynthesis (By similarity) BIZ35_03185 ENOG4105D00 flagellar biosynthetic protein flhB BIZ35_03190 ENOG4105D7B Flagellar biosynthesis protein flha BIZ35_03195 ENOG4105FZW flagellar biosynthesis regulator FlhF BIZ35_03205 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) BIZ35_03210 ENOG4105CBS Chea signal transduction histidine kinase BIZ35_03215 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis BIZ35_03225 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) BIZ35_03230 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BIZ35_03240 ENOG4105CE9 30S ribosomal protein S2 BIZ35_03245 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) BIZ35_03250 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BIZ35_03255 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BIZ35_03265 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BIZ35_03270 ENOG4105KNE Phosphatidate cytidylyltransferase BIZ35_03275 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BIZ35_03280 ENOG4105DZP Membrane-associated zinc metalloprotease BIZ35_03285 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BIZ35_03290 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BIZ35_03295 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) BIZ35_03300 ENOG4105CHV Transcription elongation factor NusA BIZ35_03305 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BIZ35_03310 ENOG4105VHM ribosomal protein BIZ35_03315 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BIZ35_03320 ENOG4105W7A Protein of unknown function (DUF503) BIZ35_03325 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) BIZ35_03330 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BIZ35_03335 ENOG4105DTN riboflavin biosynthesis protein ribF BIZ35_03340 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BIZ35_03345 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BIZ35_03355 ENOG4105C1V Peptidase, M16 BIZ35_03365 ENOG4105E35 Dipicolinate synthase subunit A BIZ35_03370 ENOG4108S0H Dipicolinic acid synthetase, b subunit BIZ35_03375 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BIZ35_03390 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BIZ35_03400 ENOG4105CN5 Metallo-Beta-Lactamase BIZ35_03405 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BIZ35_03415 ENOG4105CNU cell division protein FtsK BIZ35_03420 ENOG4105DIH basic membrane BIZ35_03425 ENOG4108JQ9 ABC transporter BIZ35_03430 ENOG4105UIB (ABC) transporter BIZ35_03450 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BIZ35_03455 ENOG4105XZV Protein of unknown function (DUF3243) BIZ35_03470 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BIZ35_03475 ENOG4105CEV competence damage-inducible protein BIZ35_03490 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) BIZ35_03495 ENOG4105D48 metallophosphoesterase BIZ35_03500 ENOG4105MCT stage V sporulation protein S BIZ35_03505 ENOG4105XYU peptidase (U32 family) BIZ35_03510 ENOG4105CFP Peptidase U32 BIZ35_03520 ENOG4108JUB Transcriptional regulator BIZ35_03525 ENOG4105C26 Dehydrogenase BIZ35_03530 ENOG4105C8Y Acetylornithine aminotransferase BIZ35_03535 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BIZ35_03550 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) BIZ35_03555 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) BIZ35_03560 ENOG4105X3H Excalibur domain protein BIZ35_03585 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BIZ35_03600 ENOG4106F1P AAA ATPase, central domain protein BIZ35_03605 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BIZ35_03610 ENOG4105CXI aluminum resistance protein BIZ35_03635 ENOG4105KST dependent repressor BIZ35_03645 ENOG4105CKU formyltetrahydrofolate synthetase BIZ35_03660 ENOG4105C5H ABC transporter BIZ35_03670 ENOG4108Y6J UPF0403 protein BIZ35_03685 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BIZ35_03690 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) BIZ35_03695 ENOG4108UT2 hemolysin iii BIZ35_03700 ENOG41090WU lipolytic protein G-D-S-L family BIZ35_03710 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BIZ35_03715 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BIZ35_03720 ENOG4105E0X reductase BIZ35_03730 ENOG4105C8Q Methyl-accepting chemotaxis BIZ35_03735 ENOG4105VSD UPF0346 protein BIZ35_03755 ENOG4108VXD carboxy-peptidase BIZ35_03770 ENOG4105K4I Scp-like extracellular BIZ35_03775 ENOG4107QMU Mate efflux family protein BIZ35_03785 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) BIZ35_03790 ENOG4105DQE DNA ligase BIZ35_03795 ENOG4105FDF Could be involved in DNA repair (By similarity) BIZ35_03800 ENOG410841Q phosphoesterase PA-phosphatase related protein BIZ35_03820 ENOG4105C7Z Conserved Protein BIZ35_03835 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BIZ35_03840 ENOG4105GR3 Histidine kinase BIZ35_03850 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BIZ35_03855 ENOG4105C7S Dehydrogenase BIZ35_03860 ENOG4105C26 Dehydrogenase BIZ35_03880 ENOG4108JYZ YitT family BIZ35_03885 ENOG4105C9U ATP-dependent DNA helicase RecQ BIZ35_03890 ENOG4105C72 UPF0176 protein BIZ35_03900 ENOG4108RAV Conserved protein BIZ35_03915 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BIZ35_03925 ENOG41069ER domain protein BIZ35_03960 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) BIZ35_03965 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BIZ35_03970 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BIZ35_03975 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BIZ35_03980 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BIZ35_03990 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BIZ35_03995 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BIZ35_04005 ENOG41066VF YeeE YedE family protein BIZ35_04010 ENOG4105FR1 rard protein BIZ35_04040 ENOG4105DJ2 Major Facilitator Superfamily BIZ35_04055 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BIZ35_04070 ENOG4105EUJ GTP cyclohydrolase i BIZ35_04095 ENOG4105C19 ABC transporter BIZ35_04100 ENOG4105EWM Histidine kinase BIZ35_04105 ENOG4105CJZ response regulator BIZ35_04130 ENOG4105WAB arsR family transcriptional regulator BIZ35_04135 ENOG4108RWP Major Facilitator Superfamily protein BIZ35_04150 ENOG4108R1P BIZ35_04165 ENOG41080V3 Major Facilitator superfamily BIZ35_04175 ENOG4105BZ1 (ABC) transporter BIZ35_04180 ENOG4105BZ1 (ABC) transporter BIZ35_04195 ENOG41067MG lrgb family BIZ35_04200 ENOG4105CEY Amp-dependent synthetase and ligase BIZ35_04215 ENOG41076DU acid-soluble spore protein P BIZ35_04225 ENOG4105C88 aminopeptidase BIZ35_04230 ENOG410746C Acid-soluble spore protein O BIZ35_04235 ENOG4108I0Z Aconitate hydratase BIZ35_04245 ENOG41067CD Small, acid-soluble spore protein Tlp BIZ35_04255 ENOG4105MI2 BIZ35_04260 ENOG4105W8X HesB YadR YfhF-family protein BIZ35_04265 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BIZ35_04270 ENOG4105K4P CoA-binding domain protein BIZ35_04275 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BIZ35_04295 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BIZ35_04300 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BIZ35_04325 ENOG4105EA8 2-Nitropropane dioxygenase BIZ35_04345 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BIZ35_04355 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BIZ35_04380 ENOG4108W0I acetyltransferase BIZ35_04410 ENOG4107UWY Methyltransferase BIZ35_04420 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin BIZ35_04425 ENOG4105DWF phosphomethylpyrimidine kinase BIZ35_04435 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase BIZ35_04440 ENOG4105DWF phosphomethylpyrimidine kinase BIZ35_04450 ENOG4108RPX mosc domain containing protein BIZ35_04485 ENOG4105YA8 Transcriptional regulator BIZ35_04490 ENOG4107Y80 Major Facilitator superfamily BIZ35_04495 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BIZ35_04510 ENOG41061P3 phosphosulfolactate synthase BIZ35_04515 ENOG4108N5B 2-phosphosulfolactate phosphatase BIZ35_04520 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BIZ35_04525 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BIZ35_04535 ENOG4107TXC Transcriptional regulator BIZ35_04540 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) BIZ35_04550 ENOG4107RUY (E1 component), alpha subunit BIZ35_04560 ENOG4107QKR Dehydrogenase BIZ35_04570 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BIZ35_04575 ENOG4105EGS Mechanosensitive ion channel BIZ35_04590 ENOG4108CCU Ribonucleotide-diphosphate reductase subunit beta BIZ35_04595 ENOG4108UVJ appr-1-p processing domain protein BIZ35_04600 ENOG41069DP small acid-soluble spore protein BIZ35_04610 ENOG4105CHU acetyl-coa acetyltransferase BIZ35_04615 ENOG4105CEY Amp-dependent synthetase and ligase BIZ35_04625 ENOG4108X4Q Hydrolase BIZ35_04630 ENOG4108SJC Membrane BIZ35_04645 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BIZ35_04650 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BIZ35_04655 ENOG4105EU0 Major facilitator Superfamily BIZ35_04665 ENOG4105CGK Exodeoxyribonuclease III BIZ35_04675 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BIZ35_04685 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BIZ35_04690 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) BIZ35_04715 ENOG4107TCE N-acetyltransferase BIZ35_04720 ENOG4105P8F nudix hydrolase BIZ35_04725 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BIZ35_04730 ENOG4105HUF DNA protection during starvation protein BIZ35_04740 ENOG4108TU7 Inherit from COG: (ABC) transporter BIZ35_04745 ENOG4105CJ1 ABC, transporter BIZ35_04770 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BIZ35_04780 ENOG410900P UPF0336 protein BIZ35_04785 ENOG4105CHR reductase BIZ35_04800 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) BIZ35_04805 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) BIZ35_04820 ENOG4107S21 permease BIZ35_04830 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BIZ35_04860 ENOG4105V75 Transcriptional regulator BIZ35_04865 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BIZ35_04885 ENOG4105CHM Aminotransferase BIZ35_04890 ENOG4105CH7 arginosuccinase BIZ35_04895 ENOG4105CDH Citrulline--aspartate ligase BIZ35_04900 ENOG4105DBV ornithine carbamoyltransferase BIZ35_04905 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BIZ35_04910 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BIZ35_04915 ENOG4105C8Y Acetylornithine aminotransferase BIZ35_04920 ENOG4105CAS nag kinase BIZ35_04925 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BIZ35_04930 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BIZ35_04945 ENOG4105WEF catalase BIZ35_04965 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BIZ35_04970 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family BIZ35_04975 ENOG4105F6E Acyl-transferase BIZ35_04990 ENOG4107YTP response regulator receiver protein BIZ35_04995 ENOG4107QIV Cytochrome c biogenesis protein BIZ35_05000 ENOG4105VXM UPF0154 protein BIZ35_05015 ENOG4105VPS UPF0291 protein BIZ35_05020 ENOG4108SVB resolvase BIZ35_05030 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BIZ35_05035 ENOG4105C5F glutamine synthetase BIZ35_05040 ENOG4105KV4 Transcriptional regulator BIZ35_05045 ENOG410890F Dynamin family BIZ35_05075 ENOG4105CTD carboxy-peptidase BIZ35_05080 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BIZ35_05090 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) BIZ35_05095 ENOG4106F55 Protein of unknown function (DUF1273) BIZ35_05105 ENOG4107X2U Inherit from COG: Exonuclease-like protein BIZ35_05110 ENOG4108I5C dEAD DEAH box helicase BIZ35_05115 ENOG4105VN1 Heat shock protein BIZ35_05140 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) BIZ35_05145 ENOG4105BZ4 penicillin-binding protein BIZ35_05150 ENOG4105CSM endonuclease III BIZ35_05160 ENOG4105C5S asparaginyl-tRNA synthetase BIZ35_05175 ENOG4105DVT helicase BIZ35_05180 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) BIZ35_05185 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) BIZ35_05190 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BIZ35_05205 ENOG4105CPK Glycosyl transferase (Group 1 BIZ35_05210 ENOG4105FJR Lmbe family BIZ35_05215 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BIZ35_05220 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BIZ35_05225 ENOG4108JYZ YitT family BIZ35_05250 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit BIZ35_05255 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BIZ35_05260 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BIZ35_05270 ENOG4108SXZ UPF0302 protein BIZ35_05275 ENOG41068YB TPR repeat-containing protein BIZ35_05285 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BIZ35_05295 ENOG4105CIH Imidazole acetol-phosphate transaminase BIZ35_05300 ENOG4105KHN chorismate mutase BIZ35_05305 ENOG4105D49 3-dehydroquinate synthase BIZ35_05310 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BIZ35_05315 ENOG4105BZU Histidine kinase BIZ35_05320 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BIZ35_05325 ENOG4105EAH synthase BIZ35_05330 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BIZ35_05335 ENOG4105XXQ heptaprenyl diphosphate synthase component I BIZ35_05350 ENOG4105K70 DNA-binding protein BIZ35_05355 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BIZ35_05375 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) BIZ35_05390 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BIZ35_05395 ENOG4105CAT Cytidine monophosphate kinase BIZ35_05405 ENOG4105MSI germination protein ypeb BIZ35_05410 ENOG4105F0V Cell wall hydrolase BIZ35_05420 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BIZ35_05435 ENOG4107RGJ metallophosphoesterase BIZ35_05450 ENOG4105WEF catalase BIZ35_05465 ENOG4105I7S Abortive infection protein BIZ35_05470 ENOG4105C9U ATP-dependent DNA helicase RecQ BIZ35_05485 ENOG4108SAX Membrane BIZ35_05490 ENOG4105E4C Lytic transglycosylase catalytic BIZ35_05495 ENOG4105BZU Histidine kinase BIZ35_05500 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BIZ35_05505 ENOG4105CRE cytochrome C BIZ35_05510 ENOG4107TWT Cytochrome c biogenesis protein BIZ35_05515 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BIZ35_05520 ENOG4105FE9 pseudouridine synthase BIZ35_05530 ENOG4108JIC nucleoside recognition domain protein BIZ35_05535 ENOG4105DZ1 carboxypeptidase BIZ35_05540 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) BIZ35_05545 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) BIZ35_05565 ENOG4105G6R Stage v sporulation protein ae BIZ35_05580 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BIZ35_05590 ENOG41082AN stage II sporulation protein BIZ35_05595 ENOG4105DZ1 carboxypeptidase BIZ35_05600 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BIZ35_05610 ENOG4105I3K Ferric uptake regulator, Fur family BIZ35_05615 ENOG4105MZ9 stage II sporulation protein m BIZ35_05635 ENOG4105CPC Aldo Keto reductase BIZ35_05655 ENOG4105CDW Resistance protein BIZ35_05665 ENOG4105VRS hydrolase family 18 BIZ35_05675 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BIZ35_05680 ENOG4108IXY short-chain dehydrogenase reductase BIZ35_05690 ENOG4105II7 pyrroline-5-carboxylate reductase BIZ35_05695 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BIZ35_05700 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BIZ35_05705 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BIZ35_05715 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BIZ35_05725 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BIZ35_05730 ENOG4108Y6J UPF0403 protein BIZ35_05735 ENOG4105DE4 1-phosphofructokinase BIZ35_05740 ENOG4105C7S Dehydrogenase BIZ35_05745 ENOG4105CPP Dehydrogenase, E1 component BIZ35_05760 ENOG4107RDP Dehydrogenase BIZ35_05765 ENOG4108JUB Transcriptional regulator BIZ35_05770 ENOG4108JUB Transcriptional regulator BIZ35_05780 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BIZ35_05785 ENOG4107QQR Sporulation BIZ35_05795 ENOG4105S1Z Stage IV sporulation protein B BIZ35_05800 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BIZ35_05805 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BIZ35_05810 ENOG4105DX0 Hemolysin A BIZ35_05815 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) BIZ35_05830 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BIZ35_05840 ENOG4105M7K Involved in the transcription termination process (By similarity) BIZ35_05845 ENOG4108ZSR alkaline shock protein BIZ35_05850 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BIZ35_05870 ENOG410644B Stage III sporulation protein af BIZ35_05880 ENOG4105KQ4 Stage iii sporulation protein ad BIZ35_05885 ENOG4108CQH stage III sporulation protein AC BIZ35_05890 ENOG4105KR5 Stage iii sporulation protein BIZ35_05895 ENOG4105CD2 stage iii sporulation protein aa BIZ35_05900 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BIZ35_05905 ENOG4105DC7 peptidase M24 BIZ35_05910 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BIZ35_05920 ENOG4105CBJ Metal-dependent enzyme BIZ35_05935 ENOG4105EA8 2-Nitropropane dioxygenase BIZ35_05940 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein BIZ35_05945 ENOG4105CHU acetyl-coa acetyltransferase BIZ35_05950 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BIZ35_05955 ENOG4105C26 Dehydrogenase BIZ35_05960 ENOG4105CGU Enoyl-CoA hydratase BIZ35_05965 ENOG4105CAY ferredoxin--nadp reductase BIZ35_05975 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BIZ35_05980 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BIZ35_05985 ENOG4105WZW rhodanese family BIZ35_05990 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BIZ35_06000 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) BIZ35_06005 ENOG4105C0D helicase BIZ35_06020 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BIZ35_06045 ENOG4106855 Competence protein BIZ35_06070 ENOG4105C5X domain protein BIZ35_06080 ENOG4105DKQ ROK family BIZ35_06090 ENOG4107ZXI Rhomboid family BIZ35_06095 ENOG4105WDJ 50S ribosomal protein L33 BIZ35_06105 ENOG4107RF6 penicillin-binding protein BIZ35_06115 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BIZ35_06125 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) BIZ35_06130 ENOG4108U5J '-nucleotidase BIZ35_06135 ENOG4105N80 Ferric uptake regulator, Fur family BIZ35_06140 ENOG4105FAV ABC, transporter BIZ35_06145 ENOG4105FDK ABC transporter BIZ35_06160 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) BIZ35_06175 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) BIZ35_06180 ENOG4105EGD dinuclear metal center protein, YbgI family BIZ35_06200 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BIZ35_06205 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BIZ35_06210 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BIZ35_06220 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) BIZ35_06230 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BIZ35_06235 ENOG4107YR5 Diacylglycerol kinase BIZ35_06240 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BIZ35_06245 ENOG4105CTJ Metal Dependent Phosphohydrolase BIZ35_06250 ENOG4105C9A Phoh family BIZ35_06260 ENOG41068P3 sporulation protein YqfC BIZ35_06265 ENOG4105KTH gatB Yqey BIZ35_06270 ENOG4105VCC 30S ribosomal protein S21 BIZ35_06275 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) BIZ35_06285 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BIZ35_06290 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BIZ35_06295 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BIZ35_06300 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BIZ35_06305 ENOG4105CFG Acts as a chaperone (By similarity) BIZ35_06310 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BIZ35_06320 ENOG4105CSA Coproporphyrinogen iii oxidase BIZ35_06325 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BIZ35_06330 ENOG4108ZRV stage ii sporulation protein p BIZ35_06335 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) BIZ35_06340 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) BIZ35_06345 ENOG4105TQK DNA polymerase iii, delta' subunit BIZ35_06350 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BIZ35_06355 ENOG4108UK2 deaminase BIZ35_06360 ENOG4105KQC Competence protein BIZ35_06370 ENOG4105DXX methyltransferase BIZ35_06380 ENOG4108WF2 Metal Dependent Phosphohydrolase BIZ35_06385 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BIZ35_06390 ENOG410812S Rna-binding protein BIZ35_06400 ENOG4105CQW ribosome biogenesis GTPase YqeH BIZ35_06405 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BIZ35_06410 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BIZ35_06415 ENOG4105CQB FAD linked oxidase domain protein BIZ35_06425 ENOG4107STQ Multicopper oxidase BIZ35_06430 ENOG4107Y70 Heat shock protein BIZ35_06435 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BIZ35_06450 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BIZ35_06460 ENOG4107STQ Multicopper oxidase BIZ35_06465 ENOG4107Y70 Heat shock protein BIZ35_06475 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BIZ35_06485 ENOG4108V0P LemA family BIZ35_06495 ENOG4105WMR Protein CrcB homolog BIZ35_06505 ENOG4105PGM cation diffusion facilitator family transporter BIZ35_06520 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BIZ35_06525 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BIZ35_06540 ENOG4105D3R alkyl hydroperoxide reductase BIZ35_06565 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BIZ35_06570 ENOG4105DBI uridine monophosphokinase BIZ35_06575 ENOG4108VQJ O-methyltransferase BIZ35_06580 ENOG4105HHA aminodeoxychorismate lyase BIZ35_06585 ENOG4105VPH UPF0473 protein BIZ35_06590 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) BIZ35_06595 ENOG4105VBH UPF0297 protein BIZ35_06600 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BIZ35_06605 ENOG4105C02 permease BIZ35_06610 ENOG41060CR BIZ35_06635 ENOG4105C7H Helicase, RecD TraA family BIZ35_06645 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BIZ35_06650 ENOG4105C3J Cysteine desulfurase BIZ35_06670 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BIZ35_06675 ENOG4105D1H recombination factor protein RarA BIZ35_06680 ENOG4105CUZ uba thif-type nad fad binding protein BIZ35_06695 ENOG4105C9M aspartyl-trna synthetase BIZ35_06700 ENOG4105CUT histidyl-tRNA synthetase BIZ35_06705 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BIZ35_06710 ENOG4105C0R drug resistance transporter emrb qaca subfamily BIZ35_06715 ENOG4105CW7 secretion protein, HlyD family BIZ35_06720 ENOG410834F Transcriptional regulator BIZ35_06725 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BIZ35_06730 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BIZ35_06735 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BIZ35_06740 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BIZ35_06745 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BIZ35_06755 ENOG4105CKP Polysaccharide Biosynthesis Protein BIZ35_06760 ENOG4108QG2 Membrane BIZ35_06770 ENOG4105VIE preprotein translocase, subunit YajC BIZ35_06775 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BIZ35_06780 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) BIZ35_06785 ENOG41061AI Protein of unknown function (DUF2905) BIZ35_06795 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BIZ35_06805 ENOG4105CDY transcriptional regulatory protein BIZ35_06825 ENOG4105CQC Prephenate dehydratase BIZ35_06830 ENOG41090I5 UPF0735 ACT domain-containing protein BIZ35_06835 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BIZ35_06845 ENOG4105K46 50S ribosomal protein l27 BIZ35_06850 ENOG4105X36 (ribosomal) protein BIZ35_06855 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BIZ35_06860 ENOG4105C03 ribonuclease BIZ35_06875 ENOG4107QMS site-determining protein BIZ35_06880 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) BIZ35_06890 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BIZ35_06895 ENOG4105DFF Rod shape-determining protein mreb BIZ35_06900 ENOG4105W5Q DNA repair protein (RadC BIZ35_06910 ENOG4106A3R peptidase BIZ35_06940 ENOG4105D7Q type ii secretion system BIZ35_06945 ENOG4105CZX twitching motility protein BIZ35_06950 ENOG4107QHF type ii secretion system protein e BIZ35_06985 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BIZ35_06990 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BIZ35_07000 ENOG4106AR7 Spore coat protein BIZ35_07005 ENOG41068KH stage VI sporulation protein D BIZ35_07005 ENOG41068KH stage VI sporulation protein D BIZ35_07010 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BIZ35_07015 ENOG4105D52 delta-aminolevulinic acid dehydratase BIZ35_07030 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BIZ35_07040 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BIZ35_07050 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) BIZ35_07055 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BIZ35_07060 ENOG4108IUQ atp-dependent protease BIZ35_07065 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BIZ35_07070 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BIZ35_07105 ENOG4105M59 Phosphodiesterase, mj0936 family BIZ35_07110 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BIZ35_07115 ENOG4108XJQ germination protein BIZ35_07130 ENOG4105E2A Dehydrogenase BIZ35_07150 ENOG41067TZ transcriptional regulator, MarR family BIZ35_07180 ENOG4105PFC Transcriptional regulator BIZ35_07190 ENOG4105E33 succinate dehydrogenase BIZ35_07200 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BIZ35_07220 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BIZ35_07225 ENOG4105K63 Thioredoxin BIZ35_07230 ENOG4105C10 Electron transfer flavoprotein BIZ35_07235 ENOG4105BZJ Electron transfer flavoprotein BIZ35_07240 ENOG41060WC Enoyl-CoA hydratase BIZ35_07245 ENOG4107Z3H Transcriptional regulator, TetR family BIZ35_07250 ENOG4105CEY Amp-dependent synthetase and ligase BIZ35_07255 ENOG4105C98 muts2 protein BIZ35_07260 ENOG4105DCG PHP domain protein BIZ35_07270 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) BIZ35_07280 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BIZ35_07285 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BIZ35_07290 ENOG4108RWN rrna methyltransferase BIZ35_07295 ENOG41067MF small acid-soluble spore protein BIZ35_07325 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BIZ35_07345 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BIZ35_07355 ENOG4108YYH Nadph-dependent fmn reductase BIZ35_07360 ENOG4107SDU Methyl-accepting chemotaxis BIZ35_07380 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BIZ35_07385 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BIZ35_07390 ENOG4105VJV 50s ribosomal protein L35 BIZ35_07395 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BIZ35_07410 ENOG4105C22 threonyL-tRNA synthetase BIZ35_07415 ENOG4108TDW sporulation protein YtxC BIZ35_07430 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) BIZ35_07435 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BIZ35_07440 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BIZ35_07450 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BIZ35_07455 ENOG4105C2M dna polymerase I BIZ35_07465 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BIZ35_07470 ENOG4108HMX isocitrate dehydrogenase (NADP) BIZ35_07475 ENOG4105BZN citrate synthase BIZ35_07480 ENOG4108VMM UPF0756 membrane protein BIZ35_07485 ENOG4108REF Sporulation integral membrane protein ytvi BIZ35_07495 ENOG4105CTQ phosphohexokinase BIZ35_07500 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) BIZ35_07505 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) BIZ35_07510 ENOG4105C6K Malic enzyme BIZ35_07515 ENOG4105C0B DNA polymerase III (alpha subunit) BIZ35_07520 ENOG4105VV2 BIZ35_07530 ENOG4105SFS phosphoesterase RecJ domain protein BIZ35_07545 ENOG4105E8R UPF0173 metal-dependent hydrolase BIZ35_07550 ENOG4105DC7 peptidase M24 BIZ35_07560 ENOG4107YZX Universal stress protein BIZ35_07570 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BIZ35_07580 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BIZ35_07585 ENOG4105KBJ sporulation protein ytfj BIZ35_07595 ENOG4105VK3 rdd domain containing protein BIZ35_07600 ENOG4105D07 Signal peptide peptidase, SppA BIZ35_07605 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BIZ35_07610 ENOG4105YWU small acid-soluble spore protein BIZ35_07615 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) BIZ35_07625 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) BIZ35_07630 ENOG4105U5Y Transcriptional regulator BIZ35_07640 ENOG4105BZU Histidine kinase BIZ35_07645 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BIZ35_07665 ENOG4105C26 Dehydrogenase BIZ35_07670 ENOG4108JUB Transcriptional regulator BIZ35_07685 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BIZ35_07690 ENOG4105D7V transposase BIZ35_07695 ENOG4108JB9 formate dehydrogenase BIZ35_07705 ENOG4105D06 uba thif-type nad fad binding protein BIZ35_07710 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BIZ35_07715 ENOG41067WU Molybdopterin converting factor (Subunit 1) BIZ35_07720 ENOG4108ZAF Molybdopterin BIZ35_07725 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BIZ35_07730 ENOG4105CVM Molybdenum cofactor synthesis domain protein BIZ35_07740 ENOG4105EPU Molybdenum cofactor synthesis domain protein BIZ35_07745 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BIZ35_07755 ENOG4105E0C molybdate abc transporter BIZ35_07760 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BIZ35_07770 ENOG4105F1V Acetoin utilization protein BIZ35_07775 ENOG4105W87 Cbs domain BIZ35_07780 ENOG4105DGU Histone deacetylase BIZ35_07785 ENOG4105ETE Transcriptional regulator (LacI family BIZ35_07790 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BIZ35_07805 ENOG4105DFU Cell wall formation (By similarity) BIZ35_07820 ENOG4108VDD TRNA binding domain protein BIZ35_07825 ENOG4108NKM UPF0354 protein BIZ35_07835 ENOG4108MJI response regulator BIZ35_07840 ENOG4105BZU Histidine kinase BIZ35_07850 ENOG4105BZU Histidine kinase BIZ35_07890 ENOG4105C8F Beta-lactamase domain protein BIZ35_07895 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BIZ35_07905 ENOG4108V15 phosphotransferase enzyme family BIZ35_07925 ENOG4107QSE Dipeptidase BIZ35_07930 ENOG4105YW5 deoR family transcriptional regulator BIZ35_07955 ENOG4105C8T Leucyl-tRNA synthetase BIZ35_07960 ENOG410605W Major Facilitator BIZ35_07970 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) BIZ35_07985 ENOG4105E8V Alpha Beta Hydrolase Fold protein BIZ35_07990 ENOG4108Z0R Transferase BIZ35_07995 ENOG4105CAQ asparagine synthetase BIZ35_08000 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BIZ35_08020 ENOG4108WS4 fmn reductase BIZ35_08025 ENOG4105CMG Carbohydrate kinase BIZ35_08030 ENOG4105D2X ABC transporter substrate-binding protein BIZ35_08040 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BIZ35_08055 ENOG4108RMU ferritin dps family protein BIZ35_08060 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) BIZ35_08065 ENOG4105DSE periplasmic solute binding protein BIZ35_08075 ENOG4105DTQ mandelate racemase muconate lactonizing BIZ35_08080 ENOG4105CEY Amp-dependent synthetase and ligase BIZ35_08085 ENOG4108IPT Naphthoate synthase BIZ35_08090 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BIZ35_08095 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BIZ35_08100 ENOG4105E4F Isochorismate synthase BIZ35_08105 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BIZ35_08250 ENOG4105KT7 mgtC SapB transporter BIZ35_08265 ENOG4105C59 p-type ATPase BIZ35_08270 ENOG410681U heavy metal transport detoxification protein BIZ35_08310 ENOG4106CAD Protein of unknown function (DUF3311) BIZ35_08315 ENOG4105E1V na solute symporter BIZ35_08325 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding BIZ35_08340 ENOG4105BZU Histidine kinase BIZ35_08345 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BIZ35_08350 ENOG41090UD (LipO)protein BIZ35_08355 ENOG4107GJV short-chain dehydrogenase reductase BIZ35_08365 ENOG4107VMI polysaccharide deacetylase BIZ35_08385 ENOG4107R4J Chloride channel BIZ35_08395 ENOG4105VFE sira family BIZ35_08400 ENOG4105XTG Pfam:DUF156 BIZ35_08410 ENOG4107Y9E nuclease BIZ35_08415 ENOG4105C5Y PTS System BIZ35_08435 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) BIZ35_08440 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) BIZ35_08460 ENOG4105DRS transport system, permease BIZ35_08475 ENOG4105CMD Transcriptional regulator, GntR family BIZ35_08480 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) BIZ35_08485 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) BIZ35_08490 ENOG4106Z5D Glycoside Hydrolase Family 43 BIZ35_08495 ENOG4105D5G Transposase BIZ35_08500 ENOG4106Z5D Glycoside Hydrolase Family 43 BIZ35_08505 ENOG4105C8Q Methyl-accepting chemotaxis BIZ35_08520 ENOG4105CHR reductase BIZ35_08540 ENOG4105C26 Dehydrogenase BIZ35_08560 ENOG4107PBV potassium channel BIZ35_08570 ENOG4105WG9 Conserved Protein BIZ35_08595 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BIZ35_08600 ENOG4105CV8 reductase BIZ35_08620 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) BIZ35_08625 ENOG4105Y38 Kinase-associated protein B BIZ35_08635 ENOG4105KA0 thioesterase Superfamily protein BIZ35_08660 ENOG4105E1K spore germination protein BIZ35_08670 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BIZ35_08675 ENOG41069ER domain protein BIZ35_08690 ENOG4105CEP NADH dehydrogenase BIZ35_08695 ENOG4105CAY ferredoxin--nadp reductase BIZ35_08720 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BIZ35_08730 ENOG41083MR nifu domain-containing protein BIZ35_08745 ENOG4108W5N phosphatidylglycerophosphatase a BIZ35_08750 ENOG4105D4U had-superfamily hydrolase, subfamily iia BIZ35_08760 ENOG4105MMD transcriptional regulator BIZ35_08765 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BIZ35_08770 ENOG4105FAA peptidase M23 BIZ35_08775 ENOG4108YTE sporulation protein YunB BIZ35_08780 ENOG4105KZD Domain of unknown function (DUF1805) BIZ35_08785 ENOG4107R8B 5'-nucleotidase BIZ35_08790 ENOG4105DIW FeS assembly protein SUFB BIZ35_08795 ENOG4108UNV SUF system FeS assembly protein, NifU family BIZ35_08805 ENOG4105JRK feS assembly protein SufD BIZ35_08810 ENOG4105C3K feS assembly ATPase SufC BIZ35_08830 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BIZ35_08835 ENOG41080E8 Transcriptional regulator, Spx MgsR family BIZ35_08840 ENOG4105C1G acyl-Coa dehydrogenase BIZ35_08845 ENOG4105CHU acetyl-coa acetyltransferase BIZ35_08870 ENOG4105SZ6 Thioredoxin BIZ35_08890 ENOG4105BZU Histidine kinase BIZ35_08895 ENOG4105CH6 catalase BIZ35_08900 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BIZ35_08910 ENOG4108QBV Monogalactosyldiacylglycerol synthase BIZ35_08930 ENOG4105EMN RNA polymerase sigma factor BIZ35_08950 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BIZ35_08960 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) BIZ35_08965 ENOG4105CHR reductase BIZ35_08970 ENOG4105CT4 transporter BIZ35_08975 ENOG4105D2H Uronic isomerase BIZ35_08980 ENOG4105CTX dehydratase BIZ35_08985 ENOG4107QZW Altronate oxidoreductase BIZ35_08995 ENOG4108UHU Aldolase BIZ35_09000 ENOG4107HP6 Transcriptional regulator BIZ35_09020 ENOG4105C5H ABC transporter BIZ35_09085 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BIZ35_09090 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BIZ35_09100 ENOG4105XZU Preprotein translocase, subunit SecG BIZ35_09105 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) BIZ35_09110 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BIZ35_09120 ENOG4105BZA Phosphoglycerate kinase BIZ35_09140 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BIZ35_09160 ENOG4108IEG Formate dehydrogenase Alpha subunit BIZ35_09200 ENOG4105BZ4 penicillin-binding protein BIZ35_09210 ENOG4108JQ7 (ABC) transporter BIZ35_09215 ENOG4107SN7 NLP P60 protein BIZ35_09225 ENOG4105C3U ABC transporter BIZ35_09230 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BIZ35_09235 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BIZ35_09240 ENOG4108Z86 Glutamine amidotransferase BIZ35_09250 ENOG4105D7N magnesium and cobalt transport protein CorA BIZ35_09265 ENOG4105ED1 spovr family BIZ35_09270 ENOG4108TGC Acyltransferase BIZ35_09295 ENOG4107GRR phosphate transport regulator BIZ35_09300 ENOG4105CJ3 phosphate transporter BIZ35_09315 ENOG4106AKX UPF0229 protein BIZ35_09320 ENOG4105CYN Serine protein kinase BIZ35_09330 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BIZ35_09340 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BIZ35_09345 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein BIZ35_09365 ENOG4107WD4 Releases the N-terminal proline from various substrates (By similarity) BIZ35_09375 ENOG4105DRP amino acid AbC transporter BIZ35_09380 ENOG4105CDA abc transporter atp-binding protein BIZ35_09385 ENOG4108QTI )-transporter BIZ35_09390 ENOG4106NWU BIZ35_09410 ENOG4105C6N Formate acetyltransferase BIZ35_09415 ENOG4105F1A Pyruvate formate-lyase BIZ35_09420 ENOG4107V0Z fmn reductase BIZ35_09435 ENOG4105CJ1 ABC, transporter BIZ35_09460 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BIZ35_09465 ENOG41062D9 Histidine kinase BIZ35_09515 ENOG4105ID8 Transcriptional regulator, ARAC family BIZ35_09520 ENOG4105C4C beta-galactosidase BIZ35_09540 ENOG4105D2S major facilitator superfamily BIZ35_09575 ENOG4105DEN Luciferase family BIZ35_09690 ENOG4105TUA UPF0295 protein BIZ35_09695 ENOG4107FQX Alpha-acetolactate decarboxylase BIZ35_09705 ENOG4107RSM transcriptional regulator BIZ35_09710 ENOG4105IJS Transcriptional regulator BIZ35_09715 ENOG4105C5B carbamate kinase BIZ35_09725 ENOG4105DBV ornithine carbamoyltransferase BIZ35_09735 ENOG4105G5W regulator Fur family BIZ35_09750 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BIZ35_09755 ENOG4105GVF (ABC) transporter BIZ35_09760 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BIZ35_09765 ENOG4105E2Y ABC, transporter BIZ35_09775 ENOG4107RCC Major Facilitator Superfamily BIZ35_09790 ENOG4107NBY Membrane BIZ35_09800 ENOG4105C5Y PTS System BIZ35_09805 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BIZ35_09815 ENOG4105BZ1 (ABC) transporter BIZ35_09820 ENOG4105EVI UPF0374 protein BIZ35_09835 ENOG4105CAN Short-chain dehydrogenase reductase Sdr BIZ35_09840 ENOG4105C5Q Transcriptional regulator BIZ35_09845 ENOG4105CBC glutamate synthase BIZ35_09850 ENOG4105BZ8 glutamate synthase BIZ35_09870 ENOG4105C2J ABC transporter BIZ35_09875 ENOG4105CEN a g-specific adenine glycosylase BIZ35_09880 ENOG41067AE Membrane-bound metal-dependent hydrolase BIZ35_09885 ENOG4105XHU Acid-soluble spore protein K BIZ35_09895 ENOG410902V Modulates RecA activity (By similarity) BIZ35_09905 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) BIZ35_09910 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BIZ35_09915 ENOG4105DK0 Indole-3-glycerol phosphate synthase BIZ35_09920 ENOG4108I0Q anthranilate phosphoribosyltransferase BIZ35_09925 ENOG4105DDQ anthranilate synthase BIZ35_09930 ENOG4105CRQ synthase (Component I) BIZ35_09940 ENOG4107RBB ABC transporter, permease BIZ35_09950 ENOG410624X efflux transporter, rnd family, mfp subunit BIZ35_09970 ENOG4105CJ1 ABC, transporter BIZ35_10010 ENOG4108Q9V regulatoR BIZ35_10015 ENOG4105BZU Histidine kinase BIZ35_10025 ENOG4105C26 Dehydrogenase BIZ35_10025 ENOG4105C26 Dehydrogenase BIZ35_10040 ENOG4105C8Q Methyl-accepting chemotaxis BIZ35_10045 ENOG4105C5I Dehydrogenase BIZ35_10050 ENOG4105C5R Aminotransferase BIZ35_10055 ENOG4108JQ1 Dehydrogenase BIZ35_10070 ENOG4105C7B Threonine dehydratase BIZ35_10075 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BIZ35_10080 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BIZ35_10085 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BIZ35_10090 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BIZ35_10095 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BIZ35_10100 ENOG4108ZP8 Acetolactate synthase small subunit BIZ35_10105 ENOG4105C7K acetolactate synthase BIZ35_10110 ENOG4105C01 Dihydroxy-acid dehydratase BIZ35_10150 ENOG4105D7V transposase BIZ35_10160 ENOG4106I4J membrane BIZ35_10170 ENOG4105FCD Major Facilitator BIZ35_10175 ENOG4105DY9 regulatoR BIZ35_10180 ENOG4108HRK Histidine kinase BIZ35_10185 ENOG4105HDK L-asparaginase BIZ35_10190 ENOG4107STQ Multicopper oxidase BIZ35_10200 ENOG4105ECB domain protein BIZ35_10235 ENOG4105EC8 Methyl-accepting chemotaxis BIZ35_10240 ENOG4105NX3 Membrane BIZ35_10245 ENOG4105VMP Transcriptional regulator BIZ35_10260 ENOG4107R6U sodium dicarboxylate symporter BIZ35_10265 ENOG4105SXS Protein of unknown function (DUF456) BIZ35_10285 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) BIZ35_10295 ENOG4105D7V transposase BIZ35_10315 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BIZ35_10320 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BIZ35_10325 ENOG4105C8Q Methyl-accepting chemotaxis BIZ35_10345 ENOG4105D1H recombination factor protein RarA BIZ35_10350 ENOG4105BZ1 (ABC) transporter BIZ35_10355 ENOG4105FS7 Transcriptional regulator BIZ35_10380 ENOG4105D6J arsenicaL-resistance protein BIZ35_10420 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BIZ35_10440 ENOG4106F1P AAA ATPase, central domain protein BIZ35_10505 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BIZ35_10535 ENOG4105UPD Calcium Proton BIZ35_10540 ENOG4108ISG Major Facilitator BIZ35_10545 ENOG4107U9T Pfam:Ribonuclease_BN BIZ35_10550 ENOG41068PA UPF0435 protein BIZ35_10555 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BIZ35_10560 ENOG4107RKG DJ-1/PfpI family BIZ35_10565 ENOG4105ER2 Ompa motb domain protein BIZ35_10570 ENOG4105E14 MotA TolQ exbB proton channel BIZ35_10580 ENOG4105K78 MarR family Transcriptional regulator BIZ35_10595 ENOG4108S4H thioesterase Superfamily protein BIZ35_10605 ENOG4105DZ6 Band 7 protein BIZ35_10615 ENOG4105C28 cystathionine BIZ35_10625 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) BIZ35_10630 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BIZ35_10635 ENOG4108V2W Carbonate dehydratase BIZ35_10645 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BIZ35_10680 ENOG4105PTM secreted protein BIZ35_10685 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic BIZ35_10695 ENOG4105CVJ phosphoglycerate mutase BIZ35_10700 ENOG41067QW Transcriptional regulator BIZ35_10705 ENOG4105D5G Transposase BIZ35_10725 ENOG41063ZP CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) BIZ35_10730 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) BIZ35_10790 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) BIZ35_10795 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) BIZ35_10805 ENOG4107SUZ Sodium/hydrogen exchanger family BIZ35_10810 ENOG4105D7V transposase BIZ35_10815 ENOG4105DM4 PTS System BIZ35_10820 ENOG4105E98 transcriptional regulator DeoR family BIZ35_10830 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BIZ35_10840 ENOG410667J hydrolase BIZ35_10850 ENOG4105C5Y PTS System BIZ35_10855 ENOG4107QNK )-transporter BIZ35_10860 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BIZ35_10885 ENOG4108JPW Aminotransferase BIZ35_10890 ENOG4108FN7 Aldo keto reductase BIZ35_10895 ENOG4105VDH Dihydroxyacetone kinase BIZ35_10900 ENOG4108UTZ Dihydroxyacetone kinase BIZ35_10905 ENOG4105CMT Dihydroxyacetone kinase BIZ35_10915 ENOG4108DBC nitroreductase BIZ35_10925 ENOG410635A Membrane BIZ35_10940 ENOG4105D7V transposase BIZ35_10955 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BIZ35_10975 ENOG4107QX3 carboxylase BIZ35_10980 ENOG4105E39 Enoyl-CoA hydratase BIZ35_10990 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BIZ35_10995 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BIZ35_11000 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BIZ35_11005 ENOG4105C1G acyl-Coa dehydrogenase BIZ35_11010 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BIZ35_11030 ENOG4105E98 transcriptional regulator DeoR family BIZ35_11040 ENOG4105CMT Dihydroxyacetone kinase BIZ35_11050 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BIZ35_11060 ENOG4105DJB Major Facilitator Superfamily BIZ35_11065 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BIZ35_11080 ENOG4108YZG isomerase BIZ35_11085 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BIZ35_11090 ENOG4105CBT Fructose-1,6-bisphosphatase BIZ35_11095 ENOG4105C8Y Acetylornithine aminotransferase BIZ35_11100 ENOG4108JUB Transcriptional regulator BIZ35_11105 ENOG4108IQI permease BIZ35_11150 ENOG4108IUE nitrate reductase beta subunit BIZ35_11170 ENOG4105WYW fructose-bisphosphate aldolase BIZ35_11175 ENOG4105EWU Squalene--hopene cyclase BIZ35_11180 ENOG4105E98 transcriptional regulator DeoR family BIZ35_11220 ENOG4105DZR Type I site-specific deoxyribonuclease BIZ35_11250 ENOG4108V06 Glutathione peroxidase BIZ35_11255 ENOG4105C5Y PTS System BIZ35_11300 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BIZ35_11315 ENOG4105BZW Glycerate kinase BIZ35_11320 ENOG4105D7V transposase BIZ35_11325 ENOG4105D7V transposase BIZ35_11330 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BIZ35_11335 ENOG4105CNN ABC, transporter BIZ35_11340 ENOG4105C2J ABC transporter BIZ35_11345 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) BIZ35_11350 ENOG4108RVA ribokinase BIZ35_11355 ENOG4105ETE Transcriptional regulator (LacI family BIZ35_11390 ENOG4105KTB nuclear export factor GLE1 BIZ35_11395 ENOG4108T5E Copper resistance protein BIZ35_11405 ENOG4105DJV ribulose-phosphate 3-epimerase BIZ35_11410 ENOG4105ETE Transcriptional regulator (LacI family BIZ35_11425 ENOG4105BZU Histidine kinase BIZ35_11430 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BIZ35_11445 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) BIZ35_11450 ENOG4107S2N Type III effector Hrp-dependent BIZ35_11455 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BIZ35_11465 ENOG4105C6Z Gluconate BIZ35_11470 ENOG4107WBR Protein of unknown function DUF111 BIZ35_11475 ENOG4105C8M UPF0272 protein BIZ35_11480 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase BIZ35_11515 ENOG4105QYV Membrane BIZ35_11520 ENOG4105D17 glycoside hydrolase, family 3 domain protein BIZ35_11530 ENOG4105EHZ conserved protein UCP016719 BIZ35_11545 ENOG4105BZ1 (ABC) transporter BIZ35_11550 ENOG4105BZ1 (ABC) transporter BIZ35_11565 ENOG4107TRN Xylose isomerase domain protein TIM barrel BIZ35_11570 ENOG4105F0H myo-inositol catabolism protein BIZ35_11575 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) BIZ35_11580 ENOG4107QNK )-transporter BIZ35_11585 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BIZ35_11590 ENOG4105CIB oxidoreductase Domain protein BIZ35_11595 ENOG4107QP6 Xylose isomerase domain protein TIM barrel BIZ35_11600 ENOG4105CIB oxidoreductase Domain protein BIZ35_11605 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BIZ35_11610 ENOG4107QNK )-transporter BIZ35_11620 ENOG4105D2N Aldolase BIZ35_11625 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) BIZ35_11630 ENOG4105D7K pfkb domain protein BIZ35_11635 ENOG4105DH8 myo-inositol catabolism BIZ35_11640 ENOG4105C26 Dehydrogenase BIZ35_11645 ENOG4105K4H Nlp p60 protein BIZ35_11665 ENOG4105EBR Carboxylesterase BIZ35_11670 ENOG4105EUF amidase EC 3.5.1.4 BIZ35_11680 ENOG4105C26 Dehydrogenase BIZ35_11705 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BIZ35_11715 ENOG4108UZX fmn reductase BIZ35_11720 ENOG4105E2Y ABC, transporter BIZ35_11725 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BIZ35_11730 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BIZ35_11735 ENOG4105GVF (ABC) transporter BIZ35_11760 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BIZ35_11770 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) BIZ35_11775 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BIZ35_11785 ENOG4107RHR regulatoR BIZ35_11805 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) BIZ35_11820 ENOG4105E7W lamb ycsf family protein BIZ35_11830 ENOG4105P4J Allophanate hydrolase, subunit 1 BIZ35_11835 ENOG4105CZM Major Facilitator BIZ35_11840 ENOG4108X3M OsmC Ohr family protein BIZ35_11845 ENOG4105CDA abc transporter atp-binding protein BIZ35_11850 ENOG4105E5Q amino acid AbC transporter BIZ35_11855 ENOG4108HW3 (ABC) transporter BIZ35_11865 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) BIZ35_11885 ENOG4108UHU Aldolase BIZ35_11900 ENOG4108IQ3 PTS system BIZ35_11905 ENOG4105F3R pts system mannose fructose sorbose family iid BIZ35_11915 ENOG4107SCQ Iron-containing alcohol dehydrogenase BIZ35_11925 ENOG4105C5I Dehydrogenase BIZ35_11940 ENOG4106KNT transcriptional regulator BIZ35_11945 ENOG4108K4B hydrolase BIZ35_11960 ENOG4107VFR oxidoreductase BIZ35_12010 ENOG4107XZQ multidrug resistance protein BIZ35_12015 ENOG4105CHR reductase BIZ35_12060 ENOG4105F3R pts system mannose fructose sorbose family iid BIZ35_12155 ENOG4105CK7 Sodium proline symporter BIZ35_12165 ENOG4105CBD Diacylglycerol kinase BIZ35_12190 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BIZ35_12195 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BIZ35_12200 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BIZ35_12210 ENOG4107QP3 malate synthase g BIZ35_12225 ENOG4105C4R Atp-dependent dna helicase BIZ35_12230 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) BIZ35_12235 ENOG4105KGF protein, YerC YecD BIZ35_12240 ENOG4108R5T secreted protein BIZ35_12255 ENOG4105C12 Phosphoribosylglycinamide synthetase BIZ35_12260 ENOG4105DC1 bifunctional purine biosynthesis protein purh BIZ35_12265 ENOG4108V3E phosphoribosylglycinamide formyltransferase BIZ35_12270 ENOG4105CXB phosphoribosylaminoimidazole synthetase BIZ35_12280 ENOG4107QIK phosphoribosylformylglycinamidine synthase BIZ35_12285 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I BIZ35_12290 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BIZ35_12300 ENOG4105C83 adenylosuccinate lyase BIZ35_12305 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BIZ35_12310 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BIZ35_12325 ENOG4107ZXU DSBA oxidoreductase BIZ35_12345 ENOG4105CK2 sodium dicarboxylate symporter BIZ35_12355 ENOG4105CID antiterminator BIZ35_12360 ENOG4105C7N Xanthine uracil vitamin C permease BIZ35_12370 ENOG4105BZ1 (ABC) transporter BIZ35_12375 ENOG4105D94 Major Facilitator Superfamily BIZ35_12380 ENOG4105WH1 Two component transcriptional regulator luxr family BIZ35_12385 ENOG4105BZU Histidine kinase BIZ35_12390 ENOG4105CJ1 ABC, transporter BIZ35_12400 ENOG4108KYE ABC-2 type transporter BIZ35_12420 ENOG4107QPK )-transporter BIZ35_12445 ENOG4105CZV ABC transporter BIZ35_12450 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BIZ35_12455 ENOG4105U3E Transcriptional regulator BIZ35_12460 ENOG4105PY6 Phenolic acid decarboxylase BIZ35_12465 ENOG4108RYK Nad-dependent epimerase dehydratase BIZ35_12470 ENOG4108Z40 Transcriptional regulator BIZ35_12495 ENOG4105CUC YeeE YedE family protein BIZ35_12500 ENOG4107QKS N-acylglucosamine 2-epimerase BIZ35_12525 ENOG4105E0A ABC, transporter BIZ35_12530 ENOG4105EHG Permease protein BIZ35_12550 ENOG41067QW Transcriptional regulator BIZ35_12565 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BIZ35_12570 ENOG4107RA1 nh(3)-dependent nad( ) synthetase BIZ35_12575 ENOG4105DAP Nicotinate phosphoribosyltransferase BIZ35_12590 ENOG4105DTQ mandelate racemase muconate lactonizing BIZ35_12610 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BIZ35_12615 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BIZ35_12620 ENOG4108TYN CAAX amino terminal protease family protein BIZ35_12630 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BIZ35_12635 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) BIZ35_12640 ENOG4105C5H ABC transporter BIZ35_12650 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BIZ35_12655 ENOG410801F ribosomal-protein-alanine acetyltransferase BIZ35_12660 ENOG41072GX Peptidase M22 Glycoprotease BIZ35_12665 ENOG4105K8N protein family UPF0079, ATPase BIZ35_12750 ENOG410906U SprT-like BIZ35_12765 ENOG41064BQ Phosphatase BIZ35_12775 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BIZ35_12780 ENOG4105WN5 stage II sporulation protein BIZ35_12785 ENOG4107SGM protein serine threonine phosphatase BIZ35_12790 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase BIZ35_12795 ENOG4105FUA antagonist BIZ35_12800 ENOG4107MMM Anti-sigma-factor antagonist BIZ35_12810 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BIZ35_12825 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BIZ35_12830 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) BIZ35_12845 ENOG4105C1J atp-dependent rna helicase BIZ35_12870 ENOG4107URF beta-phospho-glucomutase BIZ35_12875 ENOG4105FKQ transcriptional regulator BIZ35_12880 ENOG4105CG3 alpha amylase, catalytic region BIZ35_12885 ENOG4108IUK alpha amylase, catalytic BIZ35_12890 ENOG4107FKK extracellular solute-binding protein family 1 BIZ35_12895 ENOG4105D56 permease protein BIZ35_12900 ENOG4105EG2 ABC transporter, permease BIZ35_12915 ENOG4105CG3 alpha amylase, catalytic region BIZ35_12920 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BIZ35_12925 ENOG4105CPF Cell wall formation (By similarity) BIZ35_12940 ENOG4105C37 (CBS) domain BIZ35_12950 ENOG4105C37 (CBS) domain BIZ35_12960 ENOG4105C0D helicase BIZ35_12975 ENOG4105Z8H single-stranded DNA-binding protein BIZ35_12980 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) BIZ35_12985 ENOG4105CGA flagellar basal-body rod protein FlgG BIZ35_12995 ENOG4105DFF Rod shape-determining protein mreb BIZ35_13000 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BIZ35_13005 ENOG4105FRN stage II sporulation protein BIZ35_13020 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BIZ35_13030 ENOG4106778 Protein of unknown function (DUF1146) BIZ35_13035 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) BIZ35_13040 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BIZ35_13045 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BIZ35_13050 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BIZ35_13055 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BIZ35_13065 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BIZ35_13070 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BIZ35_13075 ENOG41062M3 atp synthase BIZ35_13080 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BIZ35_13085 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BIZ35_13095 ENOG4108UIC UPF0340 protein BIZ35_13100 ENOG4108YZG isomerase BIZ35_13105 ENOG4105C8Q Methyl-accepting chemotaxis BIZ35_13115 ENOG410815N Probably functions as a manganese efflux pump (By similarity) BIZ35_13120 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BIZ35_13125 ENOG4108ZXQ stage ii sporulation protein r BIZ35_13130 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BIZ35_13135 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BIZ35_13145 ENOG4107104 thymidine kinase BIZ35_13150 ENOG41082DI 50s ribosomal protein l31 BIZ35_13155 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BIZ35_13160 ENOG4105CBT Fructose-1,6-bisphosphatase BIZ35_13165 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BIZ35_13170 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BIZ35_13175 ENOG4105D2N Aldolase BIZ35_13180 ENOG410812K response regulator receiver protein BIZ35_13195 ENOG4105CZV ABC transporter BIZ35_13200 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BIZ35_13205 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BIZ35_13220 ENOG4105C19 ABC transporter BIZ35_13235 ENOG4107Z3H Transcriptional regulator, TetR family BIZ35_13240 ENOG4105C1G acyl-Coa dehydrogenase BIZ35_13245 ENOG4105C1G acyl-Coa dehydrogenase BIZ35_13255 ENOG4105DF6 Fe-S oxidoreductase BIZ35_13265 ENOG4105C75 arginyL-tRNA synthetase BIZ35_13275 ENOG4105CYW agmatinase BIZ35_13280 ENOG4105BZ4 penicillin-binding protein BIZ35_13285 ENOG4108XFG YwhD family BIZ35_13290 ENOG4108Z4T Peptidase M50 BIZ35_13295 ENOG41069HH 4-oxalocrotonate tautomerase BIZ35_13305 ENOG4105DCI Phosphohydrolase BIZ35_13315 ENOG4108VCI transcription factor, rsfa family BIZ35_13325 ENOG4108IJ2 phosphate acetyltransferase BIZ35_13330 ENOG4107JTW chlorite dismutase BIZ35_13355 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BIZ35_13390 ENOG4108IUW ABC transporter BIZ35_13405 ENOG4108JJB ABC transporter BIZ35_13420 ENOG4105DWF phosphomethylpyrimidine kinase BIZ35_13430 ENOG4108TN2 lmbE family BIZ35_13435 ENOG410667J hydrolase BIZ35_13440 ENOG4105C9U ATP-dependent DNA helicase RecQ BIZ35_13445 ENOG4105G6Z alkaline phosphatase BIZ35_13450 ENOG4106KNT transcriptional regulator BIZ35_13460 ENOG4108Z66 YbaK ebsC protein BIZ35_13465 ENOG41067MG lrgb family BIZ35_13470 ENOG4105VAW lrga family BIZ35_13475 ENOG4105CMU LysR family (Transcriptional regulator BIZ35_13480 ENOG4105CAQ asparagine synthetase BIZ35_13505 ENOG4105DWK Membrane BIZ35_13510 ENOG4105CM2 brancheD-chain amino acid aminotransferase BIZ35_13520 ENOG4108NEV two component transcriptional regulator, LytTR family BIZ35_13525 ENOG4108HRK Histidine kinase BIZ35_13535 ENOG4105D01 (LipO)protein BIZ35_13540 ENOG4108UMI ABC transporter, permease BIZ35_13545 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BIZ35_13550 ENOG4105DKW ABC transporter BIZ35_13565 ENOG4105UQX Mate efflux family protein BIZ35_13570 ENOG4105X1N Glycosyl transferase family 8 BIZ35_13575 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BIZ35_13580 ENOG4105C0R drug resistance transporter emrb qaca subfamily BIZ35_13595 ENOG4105C7K acetolactate synthase BIZ35_13615 ENOG4108IJ9 (ABC) transporter BIZ35_13635 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BIZ35_13675 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) BIZ35_13680 ENOG4105EYF MMPL domain protein BIZ35_13695 ENOG4108TZY GntR Family Transcriptional Regulator BIZ35_13700 ENOG4107QRI Phosphoketolase BIZ35_13730 ENOG4106M28 alanine racemase domain protein BIZ35_13740 ENOG4105CDA abc transporter atp-binding protein BIZ35_13750 ENOG4105E5Q amino acid AbC transporter BIZ35_13755 ENOG4105DWT malate dehydrogenase (quinone) BIZ35_13760 ENOG4105DZR Type I site-specific deoxyribonuclease BIZ35_13765 ENOG4105EKX Restriction modification system DNA (Specificity BIZ35_13770 ENOG4105CVR type I restriction-modification system BIZ35_13780 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) BIZ35_13785 ENOG4105C0H protease BIZ35_13790 ENOG4105Q2H domain protein BIZ35_13805 ENOG4105BZU Histidine kinase BIZ35_13810 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BIZ35_13825 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BIZ35_13830 ENOG4105CDU Replicative dna helicase BIZ35_13835 ENOG4105K9Q Binds to the 23S rRNA (By similarity) BIZ35_13840 ENOG4105BZR domain protein BIZ35_13850 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BIZ35_13855 ENOG4108UUM single-stranded DNA-binding protein BIZ35_13860 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) BIZ35_13865 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) BIZ35_13870 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BIZ35_13875 ENOG4108R6K riboflavin synthase, subunit alpha BIZ35_13880 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BIZ35_13885 ENOG4105C3G gtp-binding protein BIZ35_13890 ENOG4105VDK protein, conserved in bacteria BIZ35_13895 ENOG4105D8X mechanosensitive ion channel BIZ35_13900 ENOG4108ZDA Sporulation protein YyaC BIZ35_13910 ENOG4105FA0 parb-like partition protein BIZ35_13915 ENOG4107QJE Chromosome Partitioning Protein BIZ35_13920 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) BIZ35_13925 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) BIZ35_13930 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BIZ35_13935 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BIZ35_13945 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BIZ35_13950 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) BIZ35_13955 ENOG4105VG0 50S ribosomal protein l34 BIZ35_13965 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BIZ35_13970 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BIZ35_13975 ENOG410848D S4 domain protein YaaA BIZ35_13980 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BIZ35_13990 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BIZ35_13995 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BIZ35_14000 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BIZ35_14035 ENOG4105CXN decarboxylase BIZ35_14040 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BIZ35_14045 ENOG4105X0R protein from nitrogen regulatory protein P-II BIZ35_14050 ENOG4105XVJ Protein of unknown function (DUF327) BIZ35_14055 ENOG4105FA2 dna polymerase iii BIZ35_14060 ENOG4105MA4 psp1 domain protein BIZ35_14065 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) BIZ35_14070 ENOG41060K3 Methyltransferase BIZ35_14075 ENOG4105VC4 domain protein BIZ35_14080 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BIZ35_14085 ENOG4105KRN Transcriptional regulator, abrb family BIZ35_14095 ENOG4105F8V Hydrolase, tatD family BIZ35_14100 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BIZ35_14105 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BIZ35_14110 ENOG4105XFA sporulation peptidase YabG BIZ35_14120 ENOG4105W42 Veg protein BIZ35_14130 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) BIZ35_14135 ENOG4105DFT pur operon repressor BIZ35_14140 ENOG4105KME endoribonuclease L-psp BIZ35_14180 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BIZ35_14185 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BIZ35_14190 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BIZ35_14195 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BIZ35_14205 ENOG4108JA2 transcriptioN-repair coupling factor BIZ35_14210 ENOG4108M14 stage v sporulation protein t BIZ35_14220 ENOG4108IY2 MazG family BIZ35_14225 ENOG41082I2 s4 domain protein BIZ35_14230 ENOG4105VYY sporulation protein yabp BIZ35_14245 ENOG41060GV RNA binding s1 domain protein BIZ35_14270 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BIZ35_14275 ENOG4108UGV hypoxanthine phosphoribosyltransferase BIZ35_14280 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BIZ35_14285 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) BIZ35_14290 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) BIZ35_14295 ENOG4105C6T cysteine synthase BIZ35_14300 ENOG4105EEI dihydropteroate synthase BIZ35_14305 ENOG4105KRF dihydroneopterin aldolase BIZ35_14310 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BIZ35_14390 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BIZ35_14400 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) BIZ35_14405 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) BIZ35_14415 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) BIZ35_14430 ENOG4105ZMH deoxynucleoside kinase BIZ35_14450 ENOG4108Z6B deaminase BIZ35_14460 ENOG4105C6E dna polymerase iii BIZ35_14465 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) BIZ35_14470 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BIZ35_14490 ENOG4105D7V transposase BIZ35_14525 ENOG4108Z0C Uvrb UvrC protein BIZ35_14530 ENOG41066A3 ATP guanido phosphotransferase BIZ35_14540 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BIZ35_14545 ENOG4105CTP PilT protein domain protein BIZ35_14550 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BIZ35_14555 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) BIZ35_14560 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BIZ35_14565 ENOG4105D7W serine acetyltransferase BIZ35_14570 ENOG4105C8N cysteinyl-tRNA synthetase BIZ35_14580 ENOG4105C2N RNA methyltransferase TrmH family group 3 BIZ35_14585 ENOG4105M0M Tetracycline resistance protein BIZ35_14590 ENOG4105QIV RNA polymerase BIZ35_14600 ENOG410683Z Preprotein translocase SecE subunit BIZ35_14605 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BIZ35_14610 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) BIZ35_14615 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) BIZ35_14620 ENOG4108VZM 50s ribosomal protein L10 BIZ35_14630 ENOG4107Y49 methyltransferase BIZ35_14635 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BIZ35_14640 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BIZ35_14645 ENOG4105XPM ribosomal protein BIZ35_14650 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) BIZ35_14655 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BIZ35_14660 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BIZ35_14680 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) BIZ35_14685 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BIZ35_14690 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BIZ35_14695 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BIZ35_14700 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BIZ35_14705 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BIZ35_14710 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) BIZ35_14715 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BIZ35_14720 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) BIZ35_14725 ENOG41082SA 50s ribosomal protein l29 BIZ35_14730 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BIZ35_14735 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) BIZ35_14740 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) BIZ35_14755 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) BIZ35_14760 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BIZ35_14765 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) BIZ35_14770 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BIZ35_14775 ENOG4105VPB 50S ribosomal protein L30 BIZ35_14780 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BIZ35_14785 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BIZ35_14790 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BIZ35_14795 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) BIZ35_14805 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits BIZ35_14810 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BIZ35_14815 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BIZ35_14820 ENOG4108ZT0 50S ribosomal protein l17 BIZ35_14825 ENOG4108JJB ABC transporter BIZ35_14830 ENOG4108JJB ABC transporter BIZ35_14835 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BIZ35_14845 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BIZ35_14850 ENOG4108UJD 30S ribosomal protein S9 BIZ35_14855 ENOG4105CH6 catalase BIZ35_14870 ENOG4107RIQ Sulfate adenylate transferase BIZ35_14875 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BIZ35_14880 ENOG4108IQI permease BIZ35_14895 ENOG4105D1F ATP-binding protein BIZ35_14915 ENOG4105D7V transposase BIZ35_14940 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein BIZ35_14950 ENOG4108NMV polysaccharide deacetylase BIZ35_14960 ENOG4105C4M (Ubiquinol oxidase) subunit I BIZ35_14965 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BIZ35_14970 ENOG4108JJ9 ABC, transporter BIZ35_14975 ENOG4108JJ8 (ABC) transporter BIZ35_15045 ENOG4107T65 Integrase BIZ35_15050 ENOG4107Y9E nuclease BIZ35_15065 ENOG41067QW Transcriptional regulator BIZ35_15110 ENOG4108NF7 phage-type endonuclease BIZ35_15115 ENOG4108PNI recT protein BIZ35_15180 ENOG4108ZXC Two component transcriptional regulator, luxr family BIZ35_15310 ENOG41068JE domain protein BIZ35_15335 ENOG4105EMN RNA polymerase sigma factor BIZ35_15345 ENOG4105C8B TIGR00159 family BIZ35_15350 ENOG4107U5W ybbr family BIZ35_15355 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BIZ35_15360 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BIZ35_15385 ENOG4105F27 Major Facilitator BIZ35_15405 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BIZ35_15410 ENOG4106YBV Methyl-accepting chemotaxis BIZ35_15435 ENOG4105C8Q Methyl-accepting chemotaxis BIZ35_15440 ENOG41080V3 Major Facilitator superfamily BIZ35_15495 ENOG4105DEN Luciferase family BIZ35_15515 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BIZ35_15540 ENOG4106K7D Major facilitator family transporter BIZ35_15575 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase BIZ35_15580 ENOG4105CHU acetyl-coa acetyltransferase BIZ35_15605 ENOG4108IJ8 ABC transporter BIZ35_15610 ENOG4105E90 ABC transporter BIZ35_15615 ENOG4105C5Y PTS System BIZ35_15620 ENOG4105C5Y PTS System BIZ35_15625 ENOG4105CG3 alpha amylase, catalytic region BIZ35_15630 ENOG4107414 GntR family transcriptional regulator BIZ35_15635 ENOG4105C6Z Gluconate BIZ35_15640 ENOG4105CMG Carbohydrate kinase BIZ35_15655 ENOG4105NQC Flavodoxin BIZ35_15665 ENOG4105IJJ transcriptional regulator, crp fnr family BIZ35_15675 ENOG410681U heavy metal transport detoxification protein BIZ35_15680 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BIZ35_15690 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BIZ35_15695 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BIZ35_15700 ENOG4105CKK Glycosyl transferase, family 2 BIZ35_15725 ENOG4108UZ3 Transporter BIZ35_15730 ENOG41080TC multidrug resistance protein BIZ35_15745 ENOG4105EHG Permease protein BIZ35_15750 ENOG4105DQ5 transport system permease protein BIZ35_15765 ENOG4105E0A ABC, transporter BIZ35_15770 ENOG4105CAY ferredoxin--nadp reductase BIZ35_15795 ENOG4105CDY transcriptional regulatory protein BIZ35_15805 ENOG4105C1G acyl-Coa dehydrogenase BIZ35_15810 ENOG4105CHR reductase BIZ35_15820 ENOG41067SE Tetr family transcriptional regulator BIZ35_15835 ENOG4105C26 Dehydrogenase BIZ35_15840 ENOG4106PMH Extracellular solute-binding protein family 3 BIZ35_15845 ENOG4105E5Q amino acid AbC transporter BIZ35_15860 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) BIZ35_15865 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BIZ35_15870 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BIZ35_15875 ENOG4108Z73 Siroheme synthase BIZ35_15880 ENOG4108UIN ybak prolyl-trna synthetase associated region BIZ35_15885 ENOG4105DCT glycerol dehydrogenase BIZ35_15890 ENOG4105CEY Amp-dependent synthetase and ligase BIZ35_15895 ENOG4105BZU Histidine kinase BIZ35_15920 ENOG4105PGM cation diffusion facilitator family transporter BIZ35_15925 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BIZ35_15940 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BIZ35_15985 ENOG4105CTS PTS system mannitol-specific BIZ35_15990 ENOG4105ETD TRANSCRIPTIONal BIZ35_15995 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase BIZ35_16000 ENOG4105C87 Aminotransferase class I and II BIZ35_16015 ENOG4105VUC UPF0237 protein BIZ35_16020 ENOG4105CAG UPF0210 protein BIZ35_16025 ENOG4108M60 Transcriptional regulator BIZ35_16040 ENOG4105D7K pfkb domain protein BIZ35_16055 ENOG41080HJ 6-phospho 3-hexuloisomerase BIZ35_16075 ENOG4105CPC Aldo Keto reductase BIZ35_16085 ENOG4105C85 amino acid BIZ35_16090 ENOG4105DUX Transporter BIZ35_16095 ENOG4108IQI permease BIZ35_16115 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BIZ35_16120 ENOG4105F38 ABC transporter, permease BIZ35_16125 ENOG4108EG7 Binding-protein-dependent transport systems, inner membrane component BIZ35_16130 ENOG4107RUE extracellular solute-binding protein family 1 BIZ35_16145 ENOG4105CUB amino acid BIZ35_16150 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) BIZ35_16160 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BIZ35_16170 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BIZ35_16175 ENOG4105C0A alcohol dehydrogenase BIZ35_16180 ENOG4105CE7 Amidase, hydantoinase carbamoylase family BIZ35_16185 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease BIZ35_16190 ENOG4105BZ8 glutamate synthase BIZ35_16195 ENOG4107SJI Dehydrogenase BIZ35_16210 ENOG4105D5Q Arginine ornithine antiporter BIZ35_16215 ENOG4107QW4 alcohol dehydrogenase BIZ35_16220 ENOG4105BZU Histidine kinase BIZ35_16225 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BIZ35_16230 ENOG4108MRH transcriptional regulatory protein BIZ35_16235 ENOG4105D4T Citrate transporter BIZ35_16245 ENOG4105EEM helicase BIZ35_16275 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BIZ35_16285 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BIZ35_16295 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BIZ35_16300 ENOG4105CK2 sodium dicarboxylate symporter BIZ35_16305 ENOG4105IJJ transcriptional regulator, crp fnr family BIZ35_16325 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BIZ35_16335 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BIZ35_16350 ENOG4105CPI Metal Dependent Phosphohydrolase BIZ35_16355 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BIZ35_16360 ENOG4105C0X amino acid BIZ35_16365 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BIZ35_16370 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BIZ35_16380 ENOG4106F5Q Membrane BIZ35_16395 ENOG4105CT1 (ABC) transporter BIZ35_16400 ENOG4105EAD ABC transporter BIZ35_16405 ENOG4105DRP amino acid AbC transporter BIZ35_16435 ENOG4107ZTW SNARE associated Golgi BIZ35_16440 ENOG4107T5V SNARE associated Golgi BIZ35_16445 ENOG4108RCF TRANSCRIPTIONal BIZ35_16495 ENOG4105HTX biosynthesis protein BIZ35_16500 ENOG4107YJ4 chain length determinant protein BIZ35_16505 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BIZ35_16510 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BIZ35_16525 ENOG4105D3Q Sugar transferase BIZ35_16560 ENOG4105CJT Mannose-1-phosphate guanylyltransferase BIZ35_16565 ENOG4105C6Y Udp-glucose 6-dehydrogenase BIZ35_16595 ENOG4105CMG Carbohydrate kinase BIZ35_16610 ENOG4105D7V transposase BIZ35_16680 ENOG4105F3R pts system mannose fructose sorbose family iid BIZ35_16685 ENOG4105ETZ PTS System BIZ35_16690 ENOG4108UZY PTS System BIZ35_16695 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BIZ35_16700 ENOG4105FDP GntR family transcriptional regulator BIZ35_16705 ENOG4108IMY Transcriptional regulator BIZ35_16715 ENOG4107U7N hydantoinase B oxoprolinase BIZ35_16720 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin BIZ35_16725 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BIZ35_16735 ENOG4108EQA pts system BIZ35_16740 ENOG4105ETZ PTS System BIZ35_16745 ENOG4105F3R pts system mannose fructose sorbose family iid BIZ35_16765 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) BIZ35_16770 ENOG4105DT3 PTS system, galactitol-specific IIc component BIZ35_16780 ENOG4105DE4 1-phosphofructokinase BIZ35_16785 ENOG4105CR5 Class II aldolase adducin family protein BIZ35_16790 ENOG4108JUA Transcriptional regulator BIZ35_16805 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin BIZ35_16815 ENOG4107RID 5-oxoprolinase (ATP-hydrolyzing) BIZ35_16820 ENOG4105EA8 2-Nitropropane dioxygenase BIZ35_16825 ENOG4105UNS Pfam:DUF419 BIZ35_16835 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BIZ35_16860 ENOG4107QTZ amino acid BIZ35_16870 ENOG4108KGH TRANSCRIPTIONal BIZ35_16880 ENOG4107QM2 Aldo Keto reductase BIZ35_16905 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F BIZ35_16910 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BIZ35_16925 ENOG4105EMD TRANSCRIPTIONal BIZ35_16930 ENOG4105VZJ PTS System BIZ35_16935 ENOG4105VCP PTS System BIZ35_16945 ENOG4105CK1 PTS System BIZ35_16955 ENOG4105D7V transposase BIZ35_16965 ENOG4105CZM Major Facilitator BIZ35_16975 ENOG4105CQ4 Transcriptional regulator BIZ35_16980 ENOG4105C4C beta-galactosidase BIZ35_16990 ENOG4105R40 Glycine betaine carnitine choline BIZ35_16995 ENOG4108HQR Glycine betaine BIZ35_17000 ENOG4105E90 ABC transporter BIZ35_17005 ENOG4108IJ8 ABC transporter BIZ35_17010 ENOG4107HG4 Transcriptional regulator BIZ35_17015 ENOG4108UW5 maltose o-acetyltransferase BIZ35_17025 ENOG4105D7V transposase BIZ35_17030 ENOG4107JEE Short-chain dehydrogenase reductase Sdr BIZ35_17045 ENOG4105Q95 Cupin 2, conserved barrel domain protein BIZ35_17055 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BIZ35_17070 ENOG4105C0P Mg chelatase subunit ChlI BIZ35_17080 ENOG4107SCQ Iron-containing alcohol dehydrogenase BIZ35_17085 ENOG4105C54 Major Facilitator superfamily BIZ35_17090 ENOG4105CMG Carbohydrate kinase BIZ35_17095 ENOG4105C93 Xylose Isomerase BIZ35_17110 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BIZ35_17115 ENOG4108IYU L-aspartate oxidase BIZ35_17130 ENOG4105TMB Formate nitrite transporter BIZ35_17150 ENOG4108V7D UPF0397 protein BIZ35_17160 ENOG4105DTD Dehydrogenase BIZ35_17165 ENOG4105CY2 Citrate transporter BIZ35_17170 ENOG4105C26 Dehydrogenase BIZ35_17175 ENOG4105C0A alcohol dehydrogenase BIZ35_17180 ENOG4108JUB Transcriptional regulator BIZ35_17200 ENOG4105C1G acyl-Coa dehydrogenase BIZ35_17235 ENOG4105EKQ RNA-directed DNA polymerase BIZ35_17240 ENOG4108HW3 (ABC) transporter BIZ35_17245 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic BIZ35_17250 ENOG4105CN9 Peptidase m42 family protein BIZ35_17295 ENOG4105C2F Histidine kinase BIZ35_17300 ENOG4106YYS transcriptional regulatory protein BIZ35_17315 ENOG4105CUB amino acid BIZ35_17325 ENOG4105DAA L-lactate BIZ35_17330 ENOG4105JXH GntR family transcriptional regulator BIZ35_17360 ENOG4108KGH TRANSCRIPTIONal BIZ35_17375 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BIZ35_17405 ENOG4105VCP PTS System BIZ35_17420 ENOG4105CK1 PTS System BIZ35_17425 ENOG4105CS2 ec 3.2.1.21 BIZ35_17430 ENOG4105EMD TRANSCRIPTIONal BIZ35_17435 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BIZ35_17440 ENOG4105C2X Arabinose 5-phosphate isomerase BIZ35_17445 ENOG4105CJ1 ABC, transporter BIZ35_17455 ENOG4105C28 cystathionine BIZ35_17460 ENOG4105C28 cystathionine BIZ35_17480 ENOG4107T3P ABC, transporter BIZ35_17485 ENOG41075H3 AraC family transcriptional regulator BIZ35_17530 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BIZ35_17535 ENOG41060D1 Quinol oxidase BIZ35_17545 ENOG4105BZ9 Cytochrome C oxidase, subunit I BIZ35_17550 ENOG4105E2S oxidase) subunit II BIZ35_17555 ENOG4107YBY Hydrolase BIZ35_17560 ENOG4108KGH TRANSCRIPTIONal BIZ35_17575 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) BIZ35_17580 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BIZ35_17585 ENOG41069ER domain protein BIZ35_17595 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BIZ35_17610 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BIZ35_17625 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BIZ35_17630 ENOG4108EQA pts system BIZ35_17640 ENOG4105ETZ PTS System BIZ35_17645 ENOG4105F3R pts system mannose fructose sorbose family iid