locus-tag class description BF29_1 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) BF29_100 ENOG4105C02 permease BF29_1000 ENOG4105DCG PHP domain protein BF29_1002 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) BF29_1004 ENOG41090E6 transcriptional regulator MERR family BF29_1006 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BF29_1007 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BF29_1008 ENOG4108RWN rrna methyltransferase BF29_1013 ENOG4105DQ6 Transposase BF29_1017 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BF29_1019 ENOG4108YYH Nadph-dependent fmn reductase BF29_102 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BF29_1021 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BF29_1023 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BF29_1024 ENOG4105VJV 50s ribosomal protein L35 BF29_1025 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BF29_1027 ENOG4105C22 threonyL-tRNA synthetase BF29_1028 ENOG4108TDW sporulation protein YtxC BF29_103 ENOG4105C09 Bile acid BF29_1031 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) BF29_1033 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BF29_1034 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BF29_1036 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BF29_1037 ENOG4105C2M dna polymerase I BF29_1039 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF29_104 ENOG4105F23 Fibronectin-binding protein BF29_1040 ENOG4108HMX isocitrate dehydrogenase (NADP) BF29_1041 ENOG4105BZN citrate synthase BF29_1042 ENOG4108VMM UPF0756 membrane protein BF29_1043 ENOG4108REF Sporulation integral membrane protein ytvi BF29_1045 ENOG4105CTQ phosphohexokinase BF29_1046 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) BF29_1047 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) BF29_1048 ENOG4105C6K Malic enzyme BF29_1049 ENOG4105C0B DNA polymerase III (alpha subunit) BF29_1050 ENOG4105VV2 BF29_1052 ENOG4105SFS phosphoesterase RecJ domain protein BF29_1055 ENOG4105E8R UPF0173 metal-dependent hydrolase BF29_1056 ENOG4105DC7 peptidase M24 BF29_1058 ENOG4107YZX Universal stress protein BF29_106 ENOG4105DSJ YicC domain protein BF29_1060 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BF29_1062 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BF29_1063 ENOG4105KBJ sporulation protein ytfj BF29_1065 ENOG4105VK3 rdd domain containing protein BF29_1066 ENOG4105D07 Signal peptide peptidase, SppA BF29_1067 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BF29_1068 ENOG4105YWU small acid-soluble spore protein BF29_1069 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) BF29_107 ENOG4105KC4 UPF0296 protein BF29_1071 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) BF29_1072 ENOG4105U5Y Transcriptional regulator BF29_1074 ENOG4105BZU Histidine kinase BF29_1075 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BF29_1079 ENOG4105C26 Dehydrogenase BF29_108 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BF29_1080 ENOG4108JUB Transcriptional regulator BF29_1081 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BF29_1082 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BF29_1083 ENOG4108JB9 formate dehydrogenase BF29_1085 ENOG4105D06 uba thif-type nad fad binding protein BF29_1086 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BF29_1087 ENOG41067WU Molybdopterin converting factor (Subunit 1) BF29_1088 ENOG4108ZAF Molybdopterin BF29_1089 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BF29_1090 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF29_1092 ENOG4105EPU Molybdenum cofactor synthesis domain protein BF29_1093 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BF29_1095 ENOG4105E0C molybdate abc transporter BF29_1096 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BF29_1098 ENOG4105F1V Acetoin utilization protein BF29_1099 ENOG4105W87 Cbs domain BF29_110 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BF29_1100 ENOG4105DGU Histone deacetylase BF29_1101 ENOG4105ETE Transcriptional regulator (LacI family BF29_1102 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BF29_1105 ENOG4105DFU Cell wall formation (By similarity) BF29_1108 ENOG4108VDD TRNA binding domain protein BF29_1109 ENOG4108NKM UPF0354 protein BF29_111 ENOG4105C25 Primosomal protein n' BF29_1111 ENOG4108MJI response regulator BF29_1112 ENOG4105BZU Histidine kinase BF29_1113 ENOG4105BZU Histidine kinase BF29_1115 ENOG4105C8F Beta-lactamase domain protein BF29_1117 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BF29_1119 ENOG4108V15 phosphotransferase enzyme family BF29_112 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BF29_1125 ENOG4107QSE Dipeptidase BF29_1126 ENOG4105YW5 deoR family transcriptional regulator BF29_113 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BF29_1131 ENOG4105C8T Leucyl-tRNA synthetase BF29_1132 ENOG410605W Major Facilitator BF29_1137 ENOG4105E8V Alpha Beta Hydrolase Fold protein BF29_1138 ENOG4108Z0R Transferase BF29_1139 ENOG4105CAQ asparagine synthetase BF29_114 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BF29_1140 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BF29_1141 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase BF29_1144 ENOG4105D7V transposase BF29_1146 ENOG4108WS4 fmn reductase BF29_1147 ENOG4105CMG Carbohydrate kinase BF29_1148 ENOG4105D2X ABC transporter substrate-binding protein BF29_115 ENOG4108ZF3 Phosphatase BF29_1150 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BF29_1153 ENOG4108RMU ferritin dps family protein BF29_1154 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) BF29_1156 ENOG4105DSE periplasmic solute binding protein BF29_1158 ENOG4105DTQ mandelate racemase muconate lactonizing BF29_1159 ENOG4105CEY Amp-dependent synthetase and ligase BF29_116 ENOG4105D9P serine threonine protein kinase BF29_1160 ENOG4108IPT Naphthoate synthase BF29_1161 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BF29_1162 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BF29_1163 ENOG4105E4F Isochorismate synthase BF29_1164 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BF29_117 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BF29_118 ENOG4105DJV ribulose-phosphate 3-epimerase BF29_119 ENOG4105FJ0 thiamine BF29_1194 ENOG4105KT7 mgtC SapB transporter BF29_1197 ENOG4105C59 p-type ATPase BF29_1198 ENOG410681U heavy metal transport detoxification protein BF29_12 ENOG4105CXN decarboxylase BF29_120 ENOG4105VB9 50S ribosomal protein l28 BF29_1204 ENOG4106CAD Protein of unknown function (DUF3311) BF29_1205 ENOG4105E1V na solute symporter BF29_1211 ENOG4105BZU Histidine kinase BF29_1212 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF29_1213 ENOG41090UD (LipO)protein BF29_1215 ENOG4107GJV short-chain dehydrogenase reductase BF29_1216 ENOG4107VMI polysaccharide deacetylase BF29_122 ENOG4108ZAA Alkaline-shock protein BF29_1221 ENOG4107R4J Chloride channel BF29_1222 ENOG41085GJ domain protein BF29_1223 ENOG4105XTG Pfam:DUF156 BF29_1224 ENOG4107Y9E nuclease BF29_1225 ENOG4105C5Y PTS System BF29_1228 ENOG4105DQ6 Transposase BF29_123 ENOG4105DP4 dak2 domain fusion protein ylov BF29_1230 ENOG4105D7V transposase BF29_1231 ENOG4105CHR reductase BF29_1235 ENOG4105C26 Dehydrogenase BF29_1239 ENOG4107PBV potassium channel BF29_1241 ENOG4105WG9 Conserved Protein BF29_1245 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BF29_1246 ENOG4105CV8 reductase BF29_125 ENOG4105EJQ L-serine dehydratase BF29_1250 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) BF29_1259 ENOG4105KA0 thioesterase Superfamily protein BF29_126 ENOG4105CB5 ATP-dependent DNA helicase recG BF29_1264 ENOG4105E1K spore germination protein BF29_1266 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BF29_1267 ENOG41069ER domain protein BF29_1269 ENOG4105CEP NADH dehydrogenase BF29_127 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) BF29_1270 ENOG4105CAY ferredoxin--nadp reductase BF29_1272 ENOG4107UVV polysaccharide deacetylase BF29_1274 ENOG4107QJZ Glycosyl transferase, family 2 BF29_1277 ENOG4105D7V transposase BF29_1279 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BF29_128 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) BF29_1282 ENOG4105DQ6 Transposase BF29_1284 ENOG41083MR nifu domain-containing protein BF29_1287 ENOG4108W5N phosphatidylglycerophosphatase a BF29_1288 ENOG4105D4U had-superfamily hydrolase, subfamily iia BF29_129 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BF29_1290 ENOG4105MMD transcriptional regulator BF29_1291 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BF29_1292 ENOG4105FAA peptidase M23 BF29_1293 ENOG4108YTE sporulation protein YunB BF29_1294 ENOG4105KZD Domain of unknown function (DUF1805) BF29_1295 ENOG4107R8B 5'-nucleotidase BF29_1296 ENOG4105DIW FeS assembly protein SUFB BF29_1297 ENOG4108UNV SUF system FeS assembly protein, NifU family BF29_1299 ENOG4105JRK feS assembly protein SufD BF29_13 ENOG4105WBI UPF0223 protein BF29_130 ENOG4105CHR reductase BF29_1300 ENOG4105C3K feS assembly ATPase SufC BF29_1303 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BF29_1304 ENOG41080E8 Transcriptional regulator, Spx MgsR family BF29_1305 ENOG4105C1G acyl-Coa dehydrogenase BF29_1306 ENOG4105CHU acetyl-coa acetyltransferase BF29_131 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BF29_1312 ENOG4105SZ6 Thioredoxin BF29_1319 ENOG4105BZU Histidine kinase BF29_132 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BF29_1320 ENOG4105CH6 catalase BF29_1321 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BF29_1322 ENOG4108ZJ4 polysaccharide deacetylase BF29_1323 ENOG4108QBV Monogalactosyldiacylglycerol synthase BF29_1326 ENOG4105EMN RNA polymerase sigma factor BF29_133 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BF29_1330 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BF29_1332 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) BF29_1333 ENOG4105CHR reductase BF29_1334 ENOG4105CT4 transporter BF29_1335 ENOG4105D2H Uronic isomerase BF29_1336 ENOG4105CTX dehydratase BF29_1337 ENOG4107QZW Altronate oxidoreductase BF29_1339 ENOG4108UHU Aldolase BF29_134 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BF29_1343 ENOG4105C5H ABC transporter BF29_1347 ENOG4105DQ6 Transposase BF29_1357 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BF29_1358 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BF29_1360 ENOG4105XZU Preprotein translocase, subunit SecG BF29_1361 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) BF29_1363 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BF29_1365 ENOG4105BZA Phosphoglycerate kinase BF29_1369 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF29_137 ENOG4105K5M 30s ribosomal protein S16 BF29_1375 ENOG4108IEG Formate dehydrogenase Alpha subunit BF29_1378 ENOG4105BZ4 penicillin-binding protein BF29_138 ENOG4108BW8 UPF0109 protein BF29_1381 ENOG4108JQ7 (ABC) transporter BF29_1382 ENOG4107SN7 NLP P60 protein BF29_1384 ENOG4105C3U ABC transporter BF29_1385 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF29_1386 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF29_1388 ENOG4105D7N magnesium and cobalt transport protein CorA BF29_1391 ENOG4105ED1 spovr family BF29_1392 ENOG4108TGC Acyltransferase BF29_1398 ENOG4107GRR phosphate transport regulator BF29_1399 ENOG4105CJ3 phosphate transporter BF29_140 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) BF29_1402 ENOG4106AKX UPF0229 protein BF29_1403 ENOG4105CYN Serine protein kinase BF29_1404 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BF29_1406 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BF29_1407 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein BF29_141 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) BF29_1411 ENOG4105DRP amino acid AbC transporter BF29_1414 ENOG4108QTI )-transporter BF29_1417 ENOG4105C6N Formate acetyltransferase BF29_1418 ENOG4105F1A Pyruvate formate-lyase BF29_1419 ENOG4107V0Z fmn reductase BF29_142 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BF29_1422 ENOG4105CJ1 ABC, transporter BF29_1428 ENOG4105DEN Luciferase family BF29_144 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BF29_1452 ENOG4105TUA UPF0295 protein BF29_1453 ENOG4107FQX Alpha-acetolactate decarboxylase BF29_1455 ENOG4107RSM transcriptional regulator BF29_1456 ENOG4105IJS Transcriptional regulator BF29_1458 ENOG4105G5W regulator Fur family BF29_1462 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BF29_1464 ENOG4107NBY Membrane BF29_1466 ENOG4105C5Y PTS System BF29_1467 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BF29_147 ENOG4105D00 flagellar biosynthetic protein flhB BF29_1470 ENOG4105BZ1 (ABC) transporter BF29_1471 ENOG4105EVI UPF0374 protein BF29_1474 ENOG4105CAN Short-chain dehydrogenase reductase Sdr BF29_1475 ENOG4105C5Q Transcriptional regulator BF29_1476 ENOG4105CBC glutamate synthase BF29_1478 ENOG4105BZ8 glutamate synthase BF29_148 ENOG4105CMV Succinyl-CoA synthetase subunit beta BF29_1480 ENOG4105CEN a g-specific adenine glycosylase BF29_1481 ENOG41067AE Membrane-bound metal-dependent hydrolase BF29_1482 ENOG4105XHU Acid-soluble spore protein K BF29_1487 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) BF29_1489 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BF29_149 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BF29_1490 ENOG4105DK0 Indole-3-glycerol phosphate synthase BF29_1491 ENOG4108I0Q anthranilate phosphoribosyltransferase BF29_1492 ENOG4105DDQ anthranilate synthase BF29_1493 ENOG4105CRQ synthase (Component I) BF29_1494 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BF29_1497 ENOG4105C8Q Methyl-accepting chemotaxis BF29_1498 ENOG4105C5I Dehydrogenase BF29_1499 ENOG4105C5R Aminotransferase BF29_150 ENOG4105C79 DNA protecting protein DprA BF29_1500 ENOG4108JQ1 Dehydrogenase BF29_1503 ENOG4105C7B Threonine dehydratase BF29_1504 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BF29_1505 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BF29_1506 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BF29_1507 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BF29_1508 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BF29_1509 ENOG4108ZP8 Acetolactate synthase small subunit BF29_1510 ENOG4105C7K acetolactate synthase BF29_1511 ENOG4105C01 Dihydroxy-acid dehydratase BF29_1515 ENOG4106I4J membrane BF29_1516 ENOG4107E6A Cytochrome p-450 BF29_1518 ENOG4105FCD Major Facilitator BF29_1519 ENOG4105DY9 regulatoR BF29_1520 ENOG4108HRK Histidine kinase BF29_1521 ENOG4105HDK L-asparaginase BF29_1522 ENOG4107STQ Multicopper oxidase BF29_1524 ENOG4105ECB domain protein BF29_153 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BF29_1531 ENOG4105NX3 Membrane BF29_1532 ENOG4105VMP Transcriptional regulator BF29_1535 ENOG4107R6U sodium dicarboxylate symporter BF29_1536 ENOG4105SXS Protein of unknown function (DUF456) BF29_154 ENOG4108HE4 integrase family BF29_1540 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) BF29_1542 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BF29_1545 ENOG4105BZ1 (ABC) transporter BF29_1547 ENOG4105BZ1 (ABC) transporter BF29_1548 ENOG4105FS7 Transcriptional regulator BF29_1549 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BF29_155 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) BF29_1554 ENOG4105UPD Calcium Proton BF29_1555 ENOG4108ISG Major Facilitator BF29_1556 ENOG4107U9T Pfam:Ribonuclease_BN BF29_1557 ENOG41068PA UPF0435 protein BF29_1558 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BF29_1559 ENOG4107RKG DJ-1/PfpI family BF29_156 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) BF29_1561 ENOG4105ER2 Ompa motb domain protein BF29_1562 ENOG4105E14 MotA TolQ exbB proton channel BF29_1564 ENOG4105K78 MarR family Transcriptional regulator BF29_1568 ENOG4108S4H thioesterase Superfamily protein BF29_157 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) BF29_1570 ENOG4105DZ6 Band 7 protein BF29_1572 ENOG4105C28 cystathionine BF29_1574 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) BF29_1575 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BF29_1576 ENOG4108V2W Carbonate dehydratase BF29_158 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BF29_1584 ENOG4105PTM secreted protein BF29_1585 ENOG4106G6Q Transcriptional regulator BF29_1586 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic BF29_1588 ENOG4105CVJ phosphoglycerate mutase BF29_1589 ENOG41067QW Transcriptional regulator BF29_159 ENOG4108ZC9 flagellar basal-body rod protein flgc BF29_1595 ENOG4105KCF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) BF29_1596 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) BF29_16 ENOG4105ECY inositol monophosphatase BF29_160 ENOG4105VQ0 flagellar hook-basal body complex protein fliE BF29_161 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) BF29_1610 ENOG4105DQ6 Transposase BF29_1613 ENOG4105FB9 CRISPR-associated protein BF29_1619 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) BF29_162 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BF29_1620 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) BF29_1622 ENOG4107SUZ Sodium/hydrogen exchanger family BF29_1623 ENOG4105DM4 PTS System BF29_1624 ENOG4105E98 transcriptional regulator DeoR family BF29_1626 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BF29_1628 ENOG410667J hydrolase BF29_1630 ENOG4105C5Y PTS System BF29_1631 ENOG4107QNK )-transporter BF29_1632 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BF29_1639 ENOG4105CUB amino acid BF29_1640 ENOG4108JPW Aminotransferase BF29_1641 ENOG4105VDH Dihydroxyacetone kinase BF29_1642 ENOG4108UTZ Dihydroxyacetone kinase BF29_1643 ENOG4105CMT Dihydroxyacetone kinase BF29_165 ENOG4106YF4 Flagellar biosynthesis chaperone BF29_1657 ENOG4108DBC nitroreductase BF29_1659 ENOG410635A Membrane BF29_1661 ENOG4105ENA helicase BF29_1662 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BF29_1667 ENOG4105EWC Purine nucleoside phosphorylase BF29_1674 ENOG4105C8Y Acetylornithine aminotransferase BF29_1675 ENOG4108JUB Transcriptional regulator BF29_1676 ENOG4107XZC Restriction modification system DNA (Specificity BF29_1679 ENOG4107SCJ type I restriction enzyme EcoKI subunit R BF29_168 ENOG410822I Flagellar hook capping protein BF29_1680 ENOG4108IQI permease BF29_1681 ENOG4105EJ2 Transcriptional regulator BF29_1685 ENOG4105WYW fructose-bisphosphate aldolase BF29_1693 ENOG4105M6F mutator MutT protein BF29_1694 ENOG4106H3A restriction BF29_1695 ENOG4105DZR Type I site-specific deoxyribonuclease BF29_170 ENOG4108JQA flagellar BF29_1700 ENOG4108V06 Glutathione peroxidase BF29_1701 ENOG4105C5Y PTS System BF29_1710 ENOG4105DQ6 Transposase BF29_1717 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BF29_172 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BF29_1720 ENOG4105BZW Glycerate kinase BF29_1721 ENOG4105D7V transposase BF29_1722 ENOG4105DQ6 Transposase BF29_1726 ENOG4105KTB nuclear export factor GLE1 BF29_1727 ENOG4108T5E Copper resistance protein BF29_173 ENOG4105DD5 Flagellar motor switch protein BF29_1734 ENOG4105BZU Histidine kinase BF29_1735 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BF29_1739 ENOG4105D17 glycoside hydrolase, family 3 domain protein BF29_174 ENOG4107YTP response regulator receiver protein BF29_1741 ENOG4105EHZ conserved protein UCP016719 BF29_1742 ENOG4105BZ1 (ABC) transporter BF29_1743 ENOG4105BZ1 (ABC) transporter BF29_1745 ENOG4105K4H Nlp p60 protein BF29_1752 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BF29_1754 ENOG4108UZX fmn reductase BF29_1755 ENOG4105E2Y ABC, transporter BF29_1756 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BF29_1757 ENOG4105FBW Monooxygenase BF29_1758 ENOG4105GVF (ABC) transporter BF29_176 ENOG4105CN7 Flagellar biosynthetic protein FliP BF29_1760 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BF29_1762 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) BF29_1763 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BF29_1765 ENOG4107RHR regulatoR BF29_1769 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) BF29_177 ENOG4105VS8 Flagellar biosynthetic protein fliq BF29_1772 ENOG4105E7W lamb ycsf family protein BF29_1774 ENOG4105P4J Allophanate hydrolase, subunit 1 BF29_1775 ENOG4105CZM Major Facilitator BF29_1776 ENOG4108X3M OsmC Ohr family protein BF29_1777 ENOG4105CDA abc transporter atp-binding protein BF29_1778 ENOG4105E5Q amino acid AbC transporter BF29_1779 ENOG4108HW3 (ABC) transporter BF29_178 ENOG4105D19 Role in flagellar biosynthesis (By similarity) BF29_1780 ENOG4105CH2 amidohydrolase BF29_1781 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) BF29_1786 ENOG4107VFR oxidoreductase BF29_179 ENOG4105D00 flagellar biosynthetic protein flhB BF29_18 ENOG4105CI3 gtp-binding protein typa BF29_180 ENOG4105D7B Flagellar biosynthesis protein flha BF29_1804 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 BF29_181 ENOG4105FZW flagellar biosynthesis regulator FlhF BF29_1827 ENOG4105NI8 Cytosine-specific methyltransferase BF29_183 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) BF29_1833 ENOG4105CK7 Sodium proline symporter BF29_1834 ENOG4105CBD Diacylglycerol kinase BF29_1838 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BF29_1839 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BF29_184 ENOG4105CBS Chea signal transduction histidine kinase BF29_1840 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BF29_1842 ENOG4107QP3 malate synthase g BF29_1845 ENOG4105C4R Atp-dependent dna helicase BF29_1846 ENOG4105EKQ RNA-directed DNA polymerase BF29_1847 ENOG4105C4R Atp-dependent dna helicase BF29_1848 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) BF29_1849 ENOG4105KGF protein, YerC YecD BF29_185 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis BF29_1850 ENOG4108R5T secreted protein BF29_1853 ENOG4105C12 Phosphoribosylglycinamide synthetase BF29_1855 ENOG4105DC1 bifunctional purine biosynthesis protein purh BF29_1856 ENOG4108V3E phosphoribosylglycinamide formyltransferase BF29_1857 ENOG4105CXB phosphoribosylaminoimidazole synthetase BF29_1859 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii BF29_1860 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I BF29_1861 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BF29_1863 ENOG4105C83 adenylosuccinate lyase BF29_1864 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BF29_1865 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BF29_1868 ENOG4107ZXU DSBA oxidoreductase BF29_187 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) BF29_1875 ENOG4105D7V transposase BF29_1877 ENOG4105DQ6 Transposase BF29_188 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF29_1880 ENOG4105CK2 sodium dicarboxylate symporter BF29_1882 ENOG4105CID antiterminator BF29_1883 ENOG4105C7N Xanthine uracil vitamin C permease BF29_1885 ENOG4105BZ1 (ABC) transporter BF29_1886 ENOG4105D94 Major Facilitator Superfamily BF29_1890 ENOG4107QPK )-transporter BF29_1899 ENOG4105D5G Transposase BF29_19 ENOG4105QA2 BF29_190 ENOG4105CE9 30S ribosomal protein S2 BF29_1901 ENOG4105CZV ABC transporter BF29_1902 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BF29_1903 ENOG4105U3E Transcriptional regulator BF29_1904 ENOG4105PY6 Phenolic acid decarboxylase BF29_1905 ENOG4108RYK Nad-dependent epimerase dehydratase BF29_1906 ENOG4108Z40 Transcriptional regulator BF29_1908 ENOG4105Y2Z radical SAM domain protein BF29_191 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) BF29_1910 ENOG4108Z15 abc transporter atp-binding protein BF29_1911 ENOG4106KKU BF29_1915 ENOG4107V6Q Cyclic nucleotide-binding domain BF29_1917 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF29_1918 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BF29_192 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BF29_1923 ENOG4105CUC YeeE YedE family protein BF29_1924 ENOG4107QKS N-acylglucosamine 2-epimerase BF29_1929 ENOG4105E0A ABC, transporter BF29_193 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BF29_1930 ENOG4105EHG Permease protein BF29_194 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BF29_1940 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BF29_1942 ENOG4107RA1 nh(3)-dependent nad( ) synthetase BF29_1943 ENOG4105DAP Nicotinate phosphoribosyltransferase BF29_1945 ENOG4105DTQ mandelate racemase muconate lactonizing BF29_1949 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BF29_195 ENOG4105KNE Phosphatidate cytidylyltransferase BF29_1950 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BF29_1951 ENOG4108TYN CAAX amino terminal protease family protein BF29_1954 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BF29_1955 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) BF29_1957 ENOG4105C5H ABC transporter BF29_1958 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BF29_1959 ENOG410801F ribosomal-protein-alanine acetyltransferase BF29_196 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BF29_1960 ENOG41072GX Peptidase M22 Glycoprotease BF29_1961 ENOG4105K8N protein family UPF0079, ATPase BF29_197 ENOG4105DZP Membrane-associated zinc metalloprotease BF29_198 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BF29_1982 ENOG410906U SprT-like BF29_1984 ENOG41064BQ Phosphatase BF29_1986 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BF29_1987 ENOG4105WN5 stage II sporulation protein BF29_1988 ENOG4107SGM protein serine threonine phosphatase BF29_1989 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase BF29_199 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BF29_1990 ENOG4105FUA antagonist BF29_1991 ENOG4107MMM Anti-sigma-factor antagonist BF29_1992 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BF29_1994 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BF29_1995 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BF29_1996 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) BF29_1998 ENOG4105D7V transposase BF29_2 ENOG4105CH2 amidohydrolase BF29_20 ENOG4108IAB Phoh family BF29_200 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) BF29_2000 ENOG4105C1J atp-dependent rna helicase BF29_2002 ENOG4107URF beta-phospho-glucomutase BF29_2003 ENOG4105FKQ transcriptional regulator BF29_2004 ENOG4105CG3 alpha amylase, catalytic region BF29_2005 ENOG4108IUK alpha amylase, catalytic BF29_2006 ENOG4107FKK extracellular solute-binding protein family 1 BF29_2007 ENOG4105D56 permease protein BF29_2008 ENOG4105EG2 ABC transporter, permease BF29_201 ENOG4105CHV Transcription elongation factor NusA BF29_2011 ENOG4105CG3 alpha amylase, catalytic region BF29_2012 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BF29_2013 ENOG4105CPF Cell wall formation (By similarity) BF29_2017 ENOG4105C37 (CBS) domain BF29_2019 ENOG4105C37 (CBS) domain BF29_202 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BF29_2023 ENOG4105C0D helicase BF29_2026 ENOG4105Z8H single-stranded DNA-binding protein BF29_2028 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) BF29_2029 ENOG4105CGA flagellar basal-body rod protein FlgG BF29_203 ENOG4105VHM ribosomal protein BF29_2031 ENOG4105DFF Rod shape-determining protein mreb BF29_2032 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BF29_2033 ENOG4105FRN stage II sporulation protein BF29_2035 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BF29_2038 ENOG4106778 Protein of unknown function (DUF1146) BF29_2039 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) BF29_204 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BF29_2040 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BF29_2041 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BF29_2042 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BF29_2043 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BF29_2045 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BF29_2046 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BF29_2047 ENOG41062M3 atp synthase BF29_2048 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BF29_2049 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BF29_205 ENOG4105W7A Protein of unknown function (DUF503) BF29_2051 ENOG4108UIC UPF0340 protein BF29_2052 ENOG4108YZG isomerase BF29_2053 ENOG4105C8Q Methyl-accepting chemotaxis BF29_206 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) BF29_2065 ENOG410815N Probably functions as a manganese efflux pump (By similarity) BF29_2066 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BF29_2067 ENOG4108ZXQ stage ii sporulation protein r BF29_2068 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BF29_2069 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BF29_207 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BF29_2071 ENOG4107104 thymidine kinase BF29_2072 ENOG41082DI 50s ribosomal protein l31 BF29_2073 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BF29_2075 ENOG4105CBT Fructose-1,6-bisphosphatase BF29_2076 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BF29_2077 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BF29_2078 ENOG4105D2N Aldolase BF29_2079 ENOG410812K response regulator receiver protein BF29_208 ENOG4105DTN riboflavin biosynthesis protein ribF BF29_2084 ENOG4105DQ6 Transposase BF29_2085 ENOG4105CZV ABC transporter BF29_2086 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BF29_2087 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BF29_209 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BF29_2092 ENOG4107Z3H Transcriptional regulator, TetR family BF29_2093 ENOG4105C1G acyl-Coa dehydrogenase BF29_2094 ENOG4105C1G acyl-Coa dehydrogenase BF29_2096 ENOG4105DF6 Fe-S oxidoreductase BF29_2098 ENOG4105C75 arginyL-tRNA synthetase BF29_210 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BF29_2100 ENOG4105CYW agmatinase BF29_2101 ENOG4105BZ4 penicillin-binding protein BF29_2102 ENOG4108XFG YwhD family BF29_2103 ENOG4108Z4T Peptidase M50 BF29_2104 ENOG41069HH 4-oxalocrotonate tautomerase BF29_2106 ENOG4105DCI Phosphohydrolase BF29_2107 ENOG4108VCI transcription factor, rsfa family BF29_2110 ENOG4108IJ2 phosphate acetyltransferase BF29_2111 ENOG4107JTW chlorite dismutase BF29_2113 ENOG4105D7V transposase BF29_2115 ENOG4105DQ6 Transposase BF29_2119 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BF29_212 ENOG4105C1V Peptidase, M16 BF29_2124 ENOG4108K88 Membrane BF29_2125 ENOG4105DTQ mandelate racemase muconate lactonizing BF29_2129 ENOG4105DWF phosphomethylpyrimidine kinase BF29_2131 ENOG4108TN2 lmbE family BF29_2132 ENOG410667J hydrolase BF29_2133 ENOG4105C9U ATP-dependent DNA helicase RecQ BF29_2134 ENOG4105G6Z alkaline phosphatase BF29_2135 ENOG4106KNT transcriptional regulator BF29_2138 ENOG41062D9 Histidine kinase BF29_214 ENOG4105E35 Dipicolinate synthase subunit A BF29_2142 ENOG4108Z66 YbaK ebsC protein BF29_2144 ENOG41067MG lrgb family BF29_2145 ENOG4105VAW lrga family BF29_2146 ENOG4105CMU LysR family (Transcriptional regulator BF29_2147 ENOG4105CAQ asparagine synthetase BF29_2149 ENOG4105DQ6 Transposase BF29_215 ENOG4108S0H Dipicolinic acid synthetase, b subunit BF29_2158 ENOG4105GIG BF29_216 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BF29_2163 ENOG4105DWK Membrane BF29_2164 ENOG4105CM2 brancheD-chain amino acid aminotransferase BF29_2166 ENOG4105D01 (LipO)protein BF29_2167 ENOG4108UMI ABC transporter, permease BF29_2168 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF29_2169 ENOG4105DKW ABC transporter BF29_2172 ENOG4105UQX Mate efflux family protein BF29_2173 ENOG4105X1N Glycosyl transferase family 8 BF29_2175 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BF29_2177 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF29_218 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BF29_2180 ENOG4105C7K acetolactate synthase BF29_2185 ENOG4108IJ9 (ABC) transporter BF29_219 ENOG4105CN5 Metallo-Beta-Lactamase BF29_2190 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BF29_2195 ENOG4105BZ1 (ABC) transporter BF29_2197 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) BF29_2207 ENOG4106M28 alanine racemase domain protein BF29_2209 ENOG4105CDA abc transporter atp-binding protein BF29_221 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BF29_2211 ENOG4105E5Q amino acid AbC transporter BF29_2216 ENOG4105DWT malate dehydrogenase (quinone) BF29_2219 ENOG4106QJ6 Integrase catalytic subunit BF29_223 ENOG4105CNU cell division protein FtsK BF29_2234 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) BF29_2235 ENOG4105C0H protease BF29_2236 ENOG4105Q2H domain protein BF29_2239 ENOG4105BZU Histidine kinase BF29_224 ENOG4105DIH basic membrane BF29_2240 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF29_2244 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BF29_2245 ENOG4105CDU Replicative dna helicase BF29_2246 ENOG4105K9Q Binds to the 23S rRNA (By similarity) BF29_2247 ENOG4105BZR domain protein BF29_2249 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BF29_225 ENOG4108JQ9 ABC transporter BF29_2250 ENOG4108UUM single-stranded DNA-binding protein BF29_2251 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) BF29_2252 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) BF29_2253 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BF29_2254 ENOG4108R6K riboflavin synthase, subunit alpha BF29_2255 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BF29_2256 ENOG4105C3G gtp-binding protein BF29_2257 ENOG4105VDK protein, conserved in bacteria BF29_2258 ENOG4105D8X mechanosensitive ion channel BF29_2259 ENOG4108ZDA Sporulation protein YyaC BF29_226 ENOG4105UIB (ABC) transporter BF29_2260 ENOG4108UQV Membrane BF29_2261 ENOG4105FA0 parb-like partition protein BF29_2262 ENOG4107QJE Chromosome Partitioning Protein BF29_2264 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) BF29_2265 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) BF29_2266 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BF29_2267 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BF29_2269 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BF29_2270 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) BF29_2271 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BF29_2272 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BF29_2275 ENOG410848D S4 domain protein YaaA BF29_2278 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BF29_2279 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BF29_2280 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BF29_2289 ENOG4105CXN decarboxylase BF29_2290 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BF29_2291 ENOG4105X0R protein from nitrogen regulatory protein P-II BF29_2292 ENOG4105XVJ Protein of unknown function (DUF327) BF29_2293 ENOG4105FA2 dna polymerase iii BF29_2294 ENOG4105MA4 psp1 domain protein BF29_2295 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) BF29_2296 ENOG41060K3 Methyltransferase BF29_2297 ENOG4105VC4 domain protein BF29_2298 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BF29_2299 ENOG4105KRN Transcriptional regulator, abrb family BF29_23 ENOG4105CNI cell division protein FtsW BF29_230 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BF29_2301 ENOG4105F8V Hydrolase, tatD family BF29_2302 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BF29_2303 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BF29_2304 ENOG4105XFA sporulation peptidase YabG BF29_2305 ENOG4105W42 Veg protein BF29_2307 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) BF29_2308 ENOG4105DFT pur operon repressor BF29_2309 ENOG4105KME endoribonuclease L-psp BF29_231 ENOG4105XZV Protein of unknown function (DUF3243) BF29_2312 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BF29_2313 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BF29_2314 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BF29_2315 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BF29_2317 ENOG4108JA2 transcriptioN-repair coupling factor BF29_2318 ENOG4108M14 stage v sporulation protein t BF29_2320 ENOG4108IY2 MazG family BF29_2321 ENOG41082I2 s4 domain protein BF29_2322 ENOG4105VYY sporulation protein yabp BF29_2325 ENOG41060GV RNA binding s1 domain protein BF29_2330 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BF29_2331 ENOG4108UGV hypoxanthine phosphoribosyltransferase BF29_2332 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BF29_2333 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) BF29_2334 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) BF29_2335 ENOG4105C6T cysteine synthase BF29_2336 ENOG4105EEI dihydropteroate synthase BF29_2337 ENOG4105KRF dihydroneopterin aldolase BF29_2338 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BF29_234 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BF29_235 ENOG4105CEV competence damage-inducible protein BF29_2360 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BF29_2362 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) BF29_2363 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) BF29_2364 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) BF29_2367 ENOG4105ZMH deoxynucleoside kinase BF29_2369 ENOG4105VRS hydrolase family 18 BF29_237 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) BF29_2371 ENOG4108Z6B deaminase BF29_2372 ENOG4105C6E dna polymerase iii BF29_2373 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) BF29_2374 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BF29_238 ENOG4105D48 metallophosphoesterase BF29_2385 ENOG4108Z0C Uvrb UvrC protein BF29_2386 ENOG41066A3 ATP guanido phosphotransferase BF29_2388 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BF29_2389 ENOG4105CTP PilT protein domain protein BF29_239 ENOG4105MCT stage V sporulation protein S BF29_2390 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BF29_2391 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) BF29_2392 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BF29_2393 ENOG4105D7W serine acetyltransferase BF29_2394 ENOG4105C8N cysteinyl-tRNA synthetase BF29_2396 ENOG4105C2N RNA methyltransferase TrmH family group 3 BF29_2397 ENOG4105M0M Tetracycline resistance protein BF29_2399 ENOG4105QIV RNA polymerase BF29_240 ENOG4105XYU peptidase (U32 family) BF29_2400 ENOG410683Z Preprotein translocase SecE subunit BF29_2401 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BF29_2402 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) BF29_2404 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) BF29_2405 ENOG4108VZM 50s ribosomal protein L10 BF29_2407 ENOG4107Y49 methyltransferase BF29_2408 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BF29_2409 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BF29_241 ENOG4105CFP Peptidase U32 BF29_2410 ENOG4105XPM ribosomal protein BF29_2411 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) BF29_2412 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BF29_2413 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BF29_2415 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) BF29_2416 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BF29_2417 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BF29_2418 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BF29_2419 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BF29_242 ENOG4105CUB amino acid BF29_2420 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BF29_2421 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) BF29_2422 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BF29_2423 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) BF29_2424 ENOG41082SA 50s ribosomal protein l29 BF29_2425 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BF29_2426 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) BF29_2428 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits BF29_243 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BF29_2430 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) BF29_2431 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BF29_2432 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) BF29_2433 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BF29_2434 ENOG4105VPB 50S ribosomal protein L30 BF29_2435 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BF29_2436 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BF29_2437 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BF29_2438 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) BF29_2439 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits BF29_2440 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BF29_2441 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BF29_2442 ENOG4108ZT0 50S ribosomal protein l17 BF29_2443 ENOG4108JJB ABC transporter BF29_2444 ENOG4108JJB ABC transporter BF29_2445 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BF29_2447 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BF29_2448 ENOG4108UJD 30S ribosomal protein S9 BF29_2451 ENOG4107RIQ Sulfate adenylate transferase BF29_2452 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BF29_2453 ENOG4108IQI permease BF29_2456 ENOG4105D1F ATP-binding protein BF29_246 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) BF29_2462 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein BF29_2467 ENOG4108NMV polysaccharide deacetylase BF29_2469 ENOG4105C4M (Ubiquinol oxidase) subunit I BF29_247 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) BF29_2470 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BF29_2471 ENOG4108JJ9 ABC, transporter BF29_2472 ENOG4108JJ8 (ABC) transporter BF29_248 ENOG4105X3H Excalibur domain protein BF29_2487 ENOG4107T65 Integrase BF29_2488 ENOG4107Y9E nuclease BF29_2493 ENOG4105WXW Antirepressor BF29_25 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BF29_2501 ENOG4108NF7 phage-type endonuclease BF29_2502 ENOG4108PNI recT protein BF29_252 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BF29_2522 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) BF29_2524 ENOG4105DQ6 Transposase BF29_2525 ENOG4107KNS BF29_254 ENOG4106F1P AAA ATPase, central domain protein BF29_255 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BF29_256 ENOG4105CXI aluminum resistance protein BF29_2562 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BF29_2563 ENOG4107T65 Integrase BF29_2564 ENOG4107Y9E nuclease BF29_2569 ENOG4105WXW Antirepressor BF29_2577 ENOG4108NF7 phage-type endonuclease BF29_2578 ENOG4108PNI recT protein BF29_2599 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) BF29_2601 ENOG4105DQ6 Transposase BF29_2602 ENOG4107KNS BF29_261 ENOG4105KST dependent repressor BF29_262 ENOG4105CKU formyltetrahydrofolate synthetase BF29_2638 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BF29_264 ENOG4105C5H ABC transporter BF29_2641 ENOG4105EMN RNA polymerase sigma factor BF29_2643 ENOG4105EMN RNA polymerase sigma factor BF29_2645 ENOG4105DQ6 Transposase BF29_2648 ENOG4105C8B TIGR00159 family BF29_2649 ENOG4107U5W ybbr family BF29_2650 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BF29_2652 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BF29_2655 ENOG4105DEN Luciferase family BF29_266 ENOG4108Y6J UPF0403 protein BF29_2665 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase BF29_2666 ENOG4105CHU acetyl-coa acetyltransferase BF29_2670 ENOG4108IJ8 ABC transporter BF29_2671 ENOG4105E90 ABC transporter BF29_2672 ENOG4105C5Y PTS System BF29_2673 ENOG4105C5Y PTS System BF29_2674 ENOG4105CG3 alpha amylase, catalytic region BF29_2675 ENOG4107414 GntR family transcriptional regulator BF29_2676 ENOG4105C6Z Gluconate BF29_2677 ENOG4105CMG Carbohydrate kinase BF29_268 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BF29_2680 ENOG4105NQC Flavodoxin BF29_2681 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BF29_2682 ENOG4105IJJ transcriptional regulator, crp fnr family BF29_2683 ENOG4105C59 p-type ATPase BF29_2687 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF29_2689 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF29_269 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) BF29_2690 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BF29_2691 ENOG4107R8N Glycosyl transferase, family 2 BF29_2694 ENOG41080TC multidrug resistance protein BF29_2697 ENOG4105EHG Permease protein BF29_2698 ENOG4105DQ5 transport system permease protein BF29_270 ENOG4108UT2 hemolysin iii BF29_2700 ENOG4105E0A ABC, transporter BF29_2701 ENOG4105CAY ferredoxin--nadp reductase BF29_2704 ENOG4105CDY transcriptional regulatory protein BF29_2706 ENOG4105C1G acyl-Coa dehydrogenase BF29_2707 ENOG4105CHR reductase BF29_271 ENOG41090WU lipolytic protein G-D-S-L family BF29_2711 ENOG41067SE Tetr family transcriptional regulator BF29_2725 ENOG4105IIP Membrane BF29_2726 ENOG4105W1N transcriptional regulator BF29_2728 ENOG4105D7V transposase BF29_2729 ENOG4105C26 Dehydrogenase BF29_273 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BF29_2735 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) BF29_2736 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BF29_2737 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BF29_2738 ENOG4108Z73 Siroheme synthase BF29_2739 ENOG4108UIN ybak prolyl-trna synthetase associated region BF29_274 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BF29_2740 ENOG4105DCT glycerol dehydrogenase BF29_2743 ENOG4105CEY Amp-dependent synthetase and ligase BF29_2749 ENOG4105PGM cation diffusion facilitator family transporter BF29_275 ENOG4105E0X reductase BF29_2751 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BF29_2753 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BF29_2758 ENOG4105D7V transposase BF29_2759 ENOG4105C87 Aminotransferase class I and II BF29_2762 ENOG4105VUC UPF0237 protein BF29_2763 ENOG4105CAG UPF0210 protein BF29_2767 ENOG4108M60 Transcriptional regulator BF29_2768 ENOG41080HJ 6-phospho 3-hexuloisomerase BF29_277 ENOG4105C8Q Methyl-accepting chemotaxis BF29_2770 ENOG4107SET aldo keto reductase BF29_2772 ENOG4105C85 amino acid BF29_2776 ENOG4105DUX Transporter BF29_2777 ENOG4108IQI permease BF29_278 ENOG4105VSD UPF0346 protein BF29_2780 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF29_2781 ENOG4105F38 ABC transporter, permease BF29_2782 ENOG4105D38 putrescine abc transporter BF29_2783 ENOG4107RUE extracellular solute-binding protein family 1 BF29_2785 ENOG4105CUB amino acid BF29_2786 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) BF29_2788 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BF29_2789 ENOG4105D5Q Arginine ornithine antiporter BF29_2790 ENOG4107QW4 alcohol dehydrogenase BF29_2791 ENOG4105BZU Histidine kinase BF29_2792 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BF29_2793 ENOG4108MRH transcriptional regulatory protein BF29_2794 ENOG4105D4T Citrate transporter BF29_2796 ENOG4105EEM helicase BF29_2799 ENOG4105D7V transposase BF29_2804 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BF29_2806 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BF29_2807 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BF29_2808 ENOG4107QJT sodium dicarboxylate symporter BF29_2809 ENOG4105IJJ transcriptional regulator, crp fnr family BF29_281 ENOG4108VXD carboxy-peptidase BF29_2811 ENOG4105DQ6 Transposase BF29_2813 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BF29_2815 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BF29_2818 ENOG4105CPI Metal Dependent Phosphohydrolase BF29_2819 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BF29_2821 ENOG4105C0X amino acid BF29_2822 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF29_2823 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BF29_2824 ENOG4106F5Q Membrane BF29_2827 ENOG4105CT1 (ABC) transporter BF29_2828 ENOG4105EAD ABC transporter BF29_2829 ENOG4105DRP amino acid AbC transporter BF29_2833 ENOG4107ZTW SNARE associated Golgi BF29_2834 ENOG4107T5V SNARE associated Golgi BF29_2835 ENOG4108RCF TRANSCRIPTIONal BF29_2846 ENOG4105HTX biosynthesis protein BF29_2847 ENOG4107YJ4 chain length determinant protein BF29_2848 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BF29_2849 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BF29_285 ENOG4105K4I Scp-like extracellular BF29_2850 ENOG4105D3Q Sugar transferase BF29_286 ENOG4107QMU Mate efflux family protein BF29_2870 ENOG4105CMG Carbohydrate kinase BF29_2872 ENOG4105E2A Dehydrogenase BF29_2873 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BF29_288 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) BF29_2881 ENOG4105D7V transposase BF29_2884 ENOG4108N67 choline binding protein BF29_2888 ENOG4105EA8 2-Nitropropane dioxygenase BF29_289 ENOG4105DQE DNA ligase BF29_2890 ENOG4105UNS Pfam:DUF419 BF29_2892 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BF29_2895 ENOG4105FB9 CRISPR-associated protein BF29_29 ENOG41064X9 cytochrome C oxidase subunit IV BF29_290 ENOG4105FDF Could be involved in DNA repair (By similarity) BF29_2904 ENOG4107QTZ amino acid BF29_2906 ENOG4108KGH TRANSCRIPTIONal BF29_2909 ENOG4107QM2 Aldo Keto reductase BF29_291 ENOG410841Q phosphoesterase PA-phosphatase related protein BF29_2912 ENOG410846T CoA-transferase family III BF29_2913 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BF29_2915 ENOG4105D7V transposase BF29_2919 ENOG4107RBJ symporter BF29_2929 ENOG4105CZM Major Facilitator BF29_2930 ENOG4105CQ4 Transcriptional regulator BF29_2932 ENOG4105C4C beta-galactosidase BF29_2934 ENOG4105R40 Glycine betaine carnitine choline BF29_2935 ENOG4108HQR Glycine betaine BF29_2936 ENOG4105E90 ABC transporter BF29_2937 ENOG4108IJ8 ABC transporter BF29_2938 ENOG4107HG4 Transcriptional regulator BF29_2939 ENOG4108UW5 maltose o-acetyltransferase BF29_294 ENOG4105C7Z Conserved Protein BF29_2943 ENOG4105Q95 Cupin 2, conserved barrel domain protein BF29_2945 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BF29_2946 ENOG4105EBR Carboxylesterase BF29_2947 ENOG4105C0P Mg chelatase subunit ChlI BF29_2950 ENOG4107SCQ Iron-containing alcohol dehydrogenase BF29_2952 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BF29_2953 ENOG4108IYU L-aspartate oxidase BF29_2958 ENOG4108M15 ABC transporter BF29_2965 ENOG4108V7D UPF0397 protein BF29_297 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF29_2971 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BF29_298 ENOG4105GR3 Histidine kinase BF29_2981 ENOG4108HW3 (ABC) transporter BF29_2982 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic BF29_2983 ENOG4105CN9 Peptidase m42 family protein BF29_2987 ENOG4105DAA L-lactate BF29_2988 ENOG4105JXH GntR family transcriptional regulator BF29_2992 ENOG4108KGH TRANSCRIPTIONal BF29_3000 ENOG4105VCP PTS System BF29_3004 ENOG4105CK1 PTS System BF29_3005 ENOG4105CS2 ec 3.2.1.21 BF29_3007 ENOG4105EMD TRANSCRIPTIONal BF29_3008 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BF29_3009 ENOG4105C2X Arabinose 5-phosphate isomerase BF29_301 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BF29_3010 ENOG4105C28 cystathionine BF29_3011 ENOG4105C28 cystathionine BF29_3015 ENOG4107T3P ABC, transporter BF29_3016 ENOG41075H3 AraC family transcriptional regulator BF29_302 ENOG4105C7S Dehydrogenase BF29_3026 ENOG41060D1 Quinol oxidase BF29_3028 ENOG4105BZ9 Cytochrome C oxidase, subunit I BF29_3029 ENOG4105E2S oxidase) subunit II BF29_303 ENOG4105C26 Dehydrogenase BF29_3030 ENOG4107YBY Hydrolase BF29_3031 ENOG4108KGH TRANSCRIPTIONal BF29_3032 ENOG4107URF beta-phospho-glucomutase BF29_3035 ENOG4107KJX Transcriptional regulator BF29_3036 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) BF29_3038 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF29_3039 ENOG41069ER domain protein BF29_3040 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BF29_3044 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BF29_3046 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BF29_3047 ENOG4108EQA pts system BF29_3049 ENOG4105ETZ PTS System BF29_3050 ENOG4105F3R pts system mannose fructose sorbose family iid BF29_3053 ENOG4105DXD 2-methylcitrate dehydratase BF29_3054 ENOG4105CR4 methylisocitrate lyase BF29_3056 ENOG4105DV0 amidase (EC 3.5.1.4 BF29_3058 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BF29_3059 ENOG4107Z6I Thiamine biosynthesis protein BF29_3061 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BF29_3062 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) BF29_3063 ENOG4105D6E homoserine dehydrogenase BF29_3066 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) BF29_3067 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BF29_3069 ENOG4108IA2 Sodium pantothenate symporter BF29_307 ENOG4108JYZ YitT family BF29_3073 ENOG4108EKI Dehydrogenase BF29_3077 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BF29_308 ENOG4105C9U ATP-dependent DNA helicase RecQ BF29_3083 ENOG4108QY0 Membrane BF29_3085 ENOG4105CZ3 stage V sporulation protein ad BF29_3087 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BF29_3088 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BF29_309 ENOG4105C72 UPF0176 protein BF29_3090 ENOG4107YZX Universal stress protein BF29_3095 ENOG4108X4Q Hydrolase BF29_310 ENOG4108RAV Conserved protein BF29_3100 ENOG4107V0Z fmn reductase BF29_3103 ENOG4107VRP DNA repair exonuclease BF29_3104 ENOG4106D4I domain protein BF29_3106 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BF29_3111 ENOG4105CHM Aminotransferase BF29_3112 ENOG4105JSC dimethylmenaquinone methyltransferase BF29_3114 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BF29_3124 ENOG4105D6J arsenicaL-resistance protein BF29_3126 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BF29_3128 ENOG4105ECP epimerase BF29_3129 ENOG4105ETU transcriptional activator (TenA BF29_313 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BF29_3132 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BF29_3135 ENOG4105FDT acyl-CoA dehydrogenase BF29_3137 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BF29_3138 ENOG4105CMR udp-glucose 4-epimerase BF29_3139 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase BF29_3140 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) BF29_3147 ENOG4105QNR S1 RNA binding domain protein BF29_3148 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BF29_3149 ENOG4105DG6 mannose-6-phosphate isomerase BF29_3150 ENOG4105CVG Homoserine O-transsuccinylase BF29_3151 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF29_3153 ENOG4105CE4 GlcNAc 6-P deacetylase BF29_3155 ENOG4105FDP GntR family transcriptional regulator BF29_3157 ENOG4107SDU Methyl-accepting chemotaxis BF29_3158 ENOG4107RVG penicillin-binding protein BF29_3159 ENOG4105ESV Glycosyl transferase, family 4 BF29_316 ENOG41069ER domain protein BF29_3160 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BF29_3162 ENOG4105WH1 Two component transcriptional regulator luxr family BF29_3163 ENOG4105CUB amino acid BF29_3166 ENOG4105MJ2 Competence protein BF29_3170 ENOG4105E1Q flagellar hook-associated protein BF29_3171 ENOG4105DTJ flagellar hook-associated protein BF29_3172 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) BF29_3173 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) BF29_3175 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BF29_3176 ENOG4105KT7 mgtC SapB transporter BF29_3177 ENOG4105D4U had-superfamily hydrolase, subfamily iia BF29_3179 ENOG4105C54 Major Facilitator superfamily BF29_3181 ENOG4105C85 amino acid BF29_3182 ENOG4105DAN ATP-dependent protease BF29_3192 ENOG4105D7V transposase BF29_3193 ENOG4108VX5 3-methyladenine DNA glycosylase BF29_3195 ENOG41083S7 flagellar protein FlaG BF29_3196 ENOG4107RT6 flagellar hook-associated BF29_3197 ENOG4105MQ3 flagellar protein FliS BF29_32 ENOG4106UY4 Inherit from COG: Scp-like extracellular BF29_3200 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BF29_3202 ENOG4105D7V transposase BF29_3204 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BF29_3205 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BF29_3208 ENOG4105CAK Cell division ATP-binding protein ftsE BF29_3209 ENOG4105CRP Part of the ABC transporter FtsEX involved in BF29_321 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) BF29_3210 ENOG4105DR5 peptidase BF29_3213 ENOG4105D6E homoserine dehydrogenase BF29_3214 ENOG4105CN1 protease BF29_3216 ENOG4105DHS permease protein BF29_3217 ENOG4105CM4 permease protein BF29_3218 ENOG4108IPW abc transporter atp-binding protein BF29_322 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BF29_3223 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF29_3225 ENOG4105BZU Histidine kinase BF29_3226 ENOG4105C1Q protoporphyrinogen oxidase BF29_3227 ENOG4105CVA phosphate BF29_3228 ENOG4105C8U phosphate abc transporter BF29_3229 ENOG4105E2Z phosphate ABC transporter (Permease BF29_3230 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BF29_3231 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BF29_3236 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BF29_3237 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF29_3238 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase BF29_324 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BF29_325 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BF29_3250 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase BF29_3251 ENOG4107RZX Teichoic acid biosynthesis protein BF29_3252 ENOG4107SJB teichoic acid biosynthesis BF29_3255 ENOG4108PY7 BF29_3257 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) BF29_3259 ENOG4107XGZ Hydrolase BF29_3260 ENOG4108S4C acetyltransferase BF29_3262 ENOG4105C3M thioredoxin reductase BF29_3263 ENOG4108Z4K mutator MutT protein BF29_3264 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BF29_3265 ENOG4105CHW UPF0052 protein BF29_3267 ENOG4105KRI phosphocarrier protein (HPr BF29_3268 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BF29_327 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BF29_3273 ENOG4105C9Q fumarate hydratase class II BF29_3274 ENOG4105YWU small acid-soluble spore protein BF29_3278 ENOG410839P BF29_328 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BF29_3282 ENOG4108UH6 UPF0754 membrane protein BF29_3285 ENOG4105CGU Enoyl-CoA hydratase BF29_3287 ENOG4108ZCF integral membrane protein BF29_3288 ENOG4108PJD permease BF29_3290 ENOG4107VRP DNA repair exonuclease BF29_3291 ENOG4106D4I domain protein BF29_3292 ENOG4105EQI Metal Dependent Phosphohydrolase BF29_3294 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF29_330 ENOG41066VF YeeE YedE family protein BF29_3300 ENOG4105NBU tryptophan transport protein BF29_3301 ENOG4105K59 histidine triad (HIT) protein BF29_3307 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BF29_3308 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BF29_3309 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BF29_331 ENOG4105FR1 rard protein BF29_3310 ENOG4105C1Q protoporphyrinogen oxidase BF29_3312 ENOG4105ECB domain protein BF29_3314 ENOG4108TVT permease BF29_3317 ENOG4108KF3 Electron transport protein SCO1 SenC BF29_3319 ENOG4106AXD BF29_3320 ENOG4105DF9 Lipoate-protein, ligase BF29_3321 ENOG4105CEY Amp-dependent synthetase and ligase BF29_3322 ENOG4108UMN azlc family BF29_3324 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BF29_3326 ENOG4105XVF Competence transcription factor BF29_3328 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination BF29_3329 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BF29_3335 ENOG4105DHF Membrane BF29_3336 ENOG4105ERH Fumarylacetoacetate hydrolase BF29_3339 ENOG4105EPR degv family BF29_3340 ENOG41073B9 BF29_3341 ENOG4108KP7 hydrolase BF29_3342 ENOG4105VG1 fes assembly suf system protein BF29_3349 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF29_3350 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BF29_3353 ENOG4108JQ7 (ABC) transporter BF29_3354 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF29_3358 ENOG4105C31 Tryptophanyl-tRNA synthetase BF29_3361 ENOG4108J59 Extracellular solute-binding protein, family 5 BF29_3362 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF29_3363 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF29_3365 ENOG4108JQ7 (ABC) transporter BF29_3366 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) BF29_3367 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis BF29_3369 ENOG4105DPN Oligoendopeptidase f BF29_337 ENOG4105DJ2 Major Facilitator Superfamily BF29_3371 ENOG4105T58 Dithiol-disulfide isomerase BF29_3372 ENOG4108Z18 K06886 hemoglobin BF29_3373 ENOG4105E4C Lytic transglycosylase catalytic BF29_3374 ENOG4105MIX Adenylate cyclase BF29_3375 ENOG4106EFP UPF0738 protein BF29_3377 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BF29_3378 ENOG4105EMS pseudouridine synthase BF29_3379 ENOG4107S1Q Phosphatase BF29_3380 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH BF29_3387 ENOG41090VF Stage v sporulation protein ac BF29_3388 ENOG4105CZ3 stage V sporulation protein ad BF29_3394 ENOG4108ZMI UPF0477 protein BF29_340 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BF29_3401 ENOG4105EVU fructokinase BF29_3402 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BF29_3403 ENOG4108IUX (ABC) transporter BF29_3404 ENOG4105RHA ABC transporter, permease BF29_3405 ENOG4105CTZ aminopeptidase c BF29_3406 ENOG4105DPN Oligoendopeptidase f BF29_3408 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BF29_3409 ENOG4105FGV Chromate BF29_3410 ENOG4105CAH Chromate BF29_3414 ENOG4107XVH Transcriptional regulator BF29_3415 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BF29_3417 ENOG4106PAW secretion accessory protein EsaA YueB BF29_3423 ENOG4105DQ6 Transposase BF29_3424 ENOG4108QY0 Membrane BF29_3428 ENOG4105CZ3 stage V sporulation protein ad BF29_343 ENOG4105EUJ GTP cyclohydrolase i BF29_3433 ENOG4105CSH Transporter BF29_3438 ENOG4105HUF DNA protection during starvation protein BF29_3439 ENOG4105EE0 oxidoreductase BF29_3440 ENOG4105BZU Histidine kinase BF29_3441 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) BF29_3443 ENOG4107TS3 membrane protein, TerC BF29_3444 ENOG410681C small acid-soluble spore protein BF29_3447 ENOG4105BZU Histidine kinase BF29_3448 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BF29_3452 ENOG4108K88 Membrane BF29_3456 ENOG4105KRI phosphocarrier protein (HPr BF29_3457 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BF29_3458 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr BF29_3459 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF29_3460 ENOG4105CHM Aminotransferase BF29_3461 ENOG4107R88 Chemotaxis protein (CheV) BF29_3462 ENOG4105UIN BF29_3463 ENOG4105EYF MMPL domain protein BF29_3467 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BF29_3468 ENOG4107SCA Formamidase (EC 3.5.1.49) BF29_3469 ENOG4107IN1 Protein of unknown function (DUF1797) BF29_348 ENOG4105C19 ABC transporter BF29_349 ENOG4105EWM Histidine kinase BF29_350 ENOG4105CJZ response regulator BF29_352 ENOG4108R1P BF29_353 ENOG41080V3 Major Facilitator superfamily BF29_355 ENOG4105BZ1 (ABC) transporter BF29_356 ENOG4105BZ1 (ABC) transporter BF29_358 ENOG4105VAW lrga family BF29_359 ENOG41067MG lrgb family BF29_360 ENOG4105CEY Amp-dependent synthetase and ligase BF29_363 ENOG41076DU acid-soluble spore protein P BF29_365 ENOG4105C88 aminopeptidase BF29_366 ENOG410746C Acid-soluble spore protein O BF29_367 ENOG4108I0Z Aconitate hydratase BF29_370 ENOG41067CD Small, acid-soluble spore protein Tlp BF29_372 ENOG4105MI2 BF29_373 ENOG4105W8X HesB YadR YfhF-family protein BF29_374 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BF29_375 ENOG4105K4P CoA-binding domain protein BF29_376 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BF29_38 ENOG4105WUC UPF0298 protein BF29_380 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BF29_381 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BF29_385 ENOG4105EA8 2-Nitropropane dioxygenase BF29_389 ENOG4108W0I acetyltransferase BF29_394 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase BF29_395 ENOG4105DWF phosphomethylpyrimidine kinase BF29_398 ENOG4108RPX mosc domain containing protein BF29_4 ENOG4105CN5 Metallo-Beta-Lactamase BF29_40 ENOG4106H78 methyltransferase BF29_407 ENOG4105YA8 Transcriptional regulator BF29_41 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BF29_411 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BF29_414 ENOG41061P3 phosphosulfolactate synthase BF29_415 ENOG4108N5B 2-phosphosulfolactate phosphatase BF29_416 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BF29_417 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BF29_42 ENOG4105H20 Sporulation integral membrane protein YlbJ BF29_422 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) BF29_424 ENOG4107RUY (E1 component), alpha subunit BF29_426 ENOG4107QKR Dehydrogenase BF29_428 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BF29_429 ENOG4105EGS Mechanosensitive ion channel BF29_43 ENOG4105D78 K07001 NTE family protein BF29_431 ENOG4108CCU Ribonucleotide-diphosphate reductase subunit beta BF29_432 ENOG4108UVJ appr-1-p processing domain protein BF29_433 ENOG41069DP small acid-soluble spore protein BF29_435 ENOG4105CHU acetyl-coa acetyltransferase BF29_436 ENOG4105CEY Amp-dependent synthetase and ligase BF29_438 ENOG4108X4Q Hydrolase BF29_443 ENOG4108SJC Membrane BF29_446 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF29_447 ENOG4105CKD glutathione-regulated potassium-efflux system protein BF29_45 ENOG41063PX domain protein BF29_455 ENOG4105DUM transcriptional regulator, lysR family BF29_456 ENOG4105DQ6 Transposase BF29_46 ENOG4105CDE UPF0348 protein BF29_466 ENOG41082YX Transcriptional regulator, arsr family BF29_467 ENOG4105D6J arsenicaL-resistance protein BF29_468 ENOG4108UXE Protein tyrosine phosphatase BF29_47 ENOG4105KNH Nucleic acid-binding protein BF29_475 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BF29_477 ENOG4105EU0 Major facilitator Superfamily BF29_478 ENOG4105CGK Exodeoxyribonuclease III BF29_479 ENOG4106KE4 Dehydrogenase BF29_48 ENOG41067VY 50S ribosomal protein L32 BF29_480 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BF29_482 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BF29_483 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) BF29_487 ENOG4107TCE N-acetyltransferase BF29_488 ENOG4105P8F nudix hydrolase BF29_489 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BF29_490 ENOG4108RMU ferritin dps family protein BF29_492 ENOG4108TU7 Inherit from COG: (ABC) transporter BF29_493 ENOG4105CJ1 ABC, transporter BF29_499 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BF29_5 ENOG4106148 UPF0356 protein BF29_50 ENOG4108YG3 N-acetyltransferase BF29_501 ENOG4105CHR reductase BF29_504 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) BF29_505 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) BF29_508 ENOG4107S21 permease BF29_510 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BF29_516 ENOG4105V75 Transcriptional regulator BF29_517 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BF29_52 ENOG41074B2 UPF0747 protein BF29_522 ENOG4105CHM Aminotransferase BF29_523 ENOG4105CH7 arginosuccinase BF29_524 ENOG4105CDH Citrulline--aspartate ligase BF29_525 ENOG4105DBV ornithine carbamoyltransferase BF29_526 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BF29_527 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BF29_528 ENOG4105C8Y Acetylornithine aminotransferase BF29_529 ENOG4105CAS nag kinase BF29_53 ENOG4108V6E Cell division protein mraZ BF29_530 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BF29_531 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BF29_538 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BF29_539 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family BF29_54 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) BF29_540 ENOG4105F6E Acyl-transferase BF29_543 ENOG4107YTP response regulator receiver protein BF29_544 ENOG4107QIV Cytochrome c biogenesis protein BF29_545 ENOG4105VXM UPF0154 protein BF29_548 ENOG4105VPS UPF0291 protein BF29_549 ENOG4108SVB resolvase BF29_55 ENOG41068DC Essential cell division protein (By similarity) BF29_551 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BF29_552 ENOG4105C5F glutamine synthetase BF29_553 ENOG4105KV4 Transcriptional regulator BF29_554 ENOG410890F Dynamin family BF29_557 ENOG4105C2W permease BF29_558 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) BF29_559 ENOG4105CTD carboxy-peptidase BF29_56 ENOG4105CJN penicillin-binding protein BF29_560 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BF29_561 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) BF29_562 ENOG4106F55 Protein of unknown function (DUF1273) BF29_564 ENOG4107X2U Inherit from COG: Exonuclease-like protein BF29_565 ENOG4108I5C dEAD DEAH box helicase BF29_566 ENOG4105VN1 Heat shock protein BF29_57 ENOG4105CJN penicillin-binding protein BF29_572 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) BF29_573 ENOG4105BZ4 penicillin-binding protein BF29_574 ENOG4105CSM endonuclease III BF29_576 ENOG4105C5S asparaginyl-tRNA synthetase BF29_579 ENOG4105DVT helicase BF29_58 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BF29_580 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) BF29_581 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) BF29_582 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BF29_585 ENOG4105CPK Glycosyl transferase (Group 1 BF29_586 ENOG4105FJR Lmbe family BF29_587 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BF29_588 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BF29_589 ENOG4108JYZ YitT family BF29_594 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit BF29_595 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BF29_596 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BF29_598 ENOG4108SXZ UPF0302 protein BF29_599 ENOG41068YB TPR repeat-containing protein BF29_60 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BF29_600 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BF29_602 ENOG4105CIH Imidazole acetol-phosphate transaminase BF29_603 ENOG4105KHN chorismate mutase BF29_604 ENOG4105D49 3-dehydroquinate synthase BF29_605 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BF29_606 ENOG4105BZU Histidine kinase BF29_607 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BF29_608 ENOG4105EAH synthase BF29_609 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BF29_61 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) BF29_610 ENOG4105XXQ heptaprenyl diphosphate synthase component I BF29_612 ENOG4105K70 DNA-binding protein BF29_613 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BF29_617 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) BF29_62 ENOG4105CNI cell division protein FtsW BF29_620 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BF29_621 ENOG4105CAT Cytidine monophosphate kinase BF29_623 ENOG4105MSI germination protein ypeb BF29_624 ENOG4105F0V Cell wall hydrolase BF29_626 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BF29_629 ENOG4107RGJ metallophosphoesterase BF29_63 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BF29_632 ENOG4105WEF catalase BF29_635 ENOG4105I7S Abortive infection protein BF29_636 ENOG4105C9U ATP-dependent DNA helicase RecQ BF29_64 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BF29_640 ENOG4108SAX Membrane BF29_641 ENOG4105E4C Lytic transglycosylase catalytic BF29_642 ENOG4105BZU Histidine kinase BF29_643 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF29_644 ENOG4105CRE cytochrome C BF29_645 ENOG4107TWT Cytochrome c biogenesis protein BF29_646 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BF29_647 ENOG4105FE9 pseudouridine synthase BF29_649 ENOG4108JIC nucleoside recognition domain protein BF29_65 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BF29_650 ENOG4105DZ1 carboxypeptidase BF29_651 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) BF29_652 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) BF29_657 ENOG4105G6R Stage v sporulation protein ae BF29_66 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BF29_660 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF29_662 ENOG41082AN stage II sporulation protein BF29_663 ENOG4105DZ1 carboxypeptidase BF29_665 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF29_667 ENOG4105I3K Ferric uptake regulator, Fur family BF29_668 ENOG4105MZ9 stage II sporulation protein m BF29_67 ENOG4108AWX Sporulation factor SpoIIGA BF29_672 ENOG4105CPC Aldo Keto reductase BF29_675 ENOG4105CDW Resistance protein BF29_677 ENOG4105VRS hydrolase family 18 BF29_679 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF29_68 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF29_680 ENOG4108IXY short-chain dehydrogenase reductase BF29_681 ENOG4105II7 pyrroline-5-carboxylate reductase BF29_682 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BF29_683 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BF29_684 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF29_686 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BF29_688 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BF29_689 ENOG4108Y6J UPF0403 protein BF29_690 ENOG4105DE4 1-phosphofructokinase BF29_691 ENOG4105C7S Dehydrogenase BF29_692 ENOG4105CPP Dehydrogenase, E1 component BF29_695 ENOG4107RDP Dehydrogenase BF29_696 ENOG4108JUB Transcriptional regulator BF29_699 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BF29_70 ENOG4105WR5 sporulation protein, YlmC YmxH family BF29_700 ENOG4107QQR Sporulation BF29_701 ENOG4105S1Z Stage IV sporulation protein B BF29_702 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BF29_703 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BF29_704 ENOG4105DX0 Hemolysin A BF29_705 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) BF29_708 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BF29_709 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BF29_71 ENOG41069ER domain protein BF29_710 ENOG4105M7K Involved in the transcription termination process (By similarity) BF29_711 ENOG4108ZSR alkaline shock protein BF29_712 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BF29_716 ENOG410644B Stage III sporulation protein af BF29_718 ENOG4105KQ4 Stage iii sporulation protein ad BF29_719 ENOG4108CQH stage III sporulation protein AC BF29_72 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BF29_720 ENOG4105KR5 Stage iii sporulation protein BF29_721 ENOG4105CD2 stage iii sporulation protein aa BF29_722 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BF29_723 ENOG4105DC7 peptidase M24 BF29_724 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BF29_726 ENOG4105CBJ Metal-dependent enzyme BF29_73 ENOG4105DFA alanine racemase domain protein BF29_731 ENOG4105CHU acetyl-coa acetyltransferase BF29_732 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF29_733 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BF29_734 ENOG4105WZW rhodanese family BF29_735 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BF29_737 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) BF29_738 ENOG4105C0D helicase BF29_74 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) BF29_741 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BF29_746 ENOG4106855 Competence protein BF29_75 ENOG41067XK integral membrane protein BF29_751 ENOG4105C5X domain protein BF29_753 ENOG4105DKQ ROK family BF29_755 ENOG4107ZXI Rhomboid family BF29_757 ENOG4105WDJ 50S ribosomal protein L33 BF29_759 ENOG4107RF6 penicillin-binding protein BF29_76 ENOG4105DBK s4 domain protein BF29_761 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF29_763 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) BF29_764 ENOG4108U5J '-nucleotidase BF29_765 ENOG4105N80 Ferric uptake regulator, Fur family BF29_766 ENOG4105FAV ABC, transporter BF29_767 ENOG4105FDK ABC transporter BF29_770 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) BF29_773 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) BF29_774 ENOG4105EGD dinuclear metal center protein, YbgI family BF29_778 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF29_779 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BF29_780 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BF29_783 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) BF29_785 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BF29_786 ENOG4107YR5 Diacylglycerol kinase BF29_787 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BF29_790 ENOG4105C9A Phoh family BF29_792 ENOG41068P3 sporulation protein YqfC BF29_793 ENOG4105KTH gatB Yqey BF29_794 ENOG4105VCC 30S ribosomal protein S21 BF29_795 ENOG410855V Acylphosphatase BF29_797 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BF29_798 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BF29_799 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BF29_80 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BF29_800 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BF29_801 ENOG4105CFG Acts as a chaperone (By similarity) BF29_802 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BF29_804 ENOG4105CSA Coproporphyrinogen iii oxidase BF29_805 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BF29_806 ENOG4108ZRV stage ii sporulation protein p BF29_807 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) BF29_808 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) BF29_809 ENOG4105TQK DNA polymerase iii, delta' subunit BF29_81 ENOG4105C34 Pseudouridine synthase BF29_811 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BF29_812 ENOG4108UK2 deaminase BF29_813 ENOG4105KQC Competence protein BF29_815 ENOG4105DXX methyltransferase BF29_817 ENOG4108WF2 Metal Dependent Phosphohydrolase BF29_818 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BF29_819 ENOG410812S Rna-binding protein BF29_82 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) BF29_821 ENOG4105CQW ribosome biogenesis GTPase YqeH BF29_822 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BF29_823 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BF29_824 ENOG4105CQB FAD linked oxidase domain protein BF29_826 ENOG4107STQ Multicopper oxidase BF29_827 ENOG4107Y70 Heat shock protein BF29_829 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BF29_83 ENOG4105CXT aspartate transcarbamylase BF29_831 ENOG4108V0P LemA family BF29_835 ENOG4105PGM cation diffusion facilitator family transporter BF29_837 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BF29_838 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF29_839 ENOG4108JU3 Alkyl hydroperoxide reductase BF29_84 ENOG4105CD3 dihydroorotase BF29_840 ENOG4105D3R alkyl hydroperoxide reductase BF29_843 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BF29_846 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BF29_847 ENOG4105DBI uridine monophosphokinase BF29_848 ENOG4108VQJ O-methyltransferase BF29_849 ENOG4105HHA aminodeoxychorismate lyase BF29_850 ENOG4105VPH UPF0473 protein BF29_851 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) BF29_852 ENOG4105VBH UPF0297 protein BF29_853 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF29_854 ENOG4105C02 permease BF29_856 ENOG41060CR BF29_858 ENOG4105C7H Helicase, RecD TraA family BF29_860 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BF29_861 ENOG4105C3J Cysteine desulfurase BF29_866 ENOG41087NI Sulfite exporter TauE/SafE BF29_867 ENOG4105VFE sira family BF29_868 ENOG4107TPS domain protein BF29_869 ENOG4108ZCA Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BF29_870 ENOG4105VFE sira family BF29_871 ENOG41085GJ domain protein BF29_872 ENOG4105XTG Pfam:DUF156 BF29_876 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BF29_877 ENOG4105K63 Thioredoxin BF29_878 ENOG4107QIV Cytochrome c biogenesis protein BF29_88 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) BF29_881 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BF29_886 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BF29_888 ENOG4105D1H recombination factor protein RarA BF29_889 ENOG4105CUZ uba thif-type nad fad binding protein BF29_892 ENOG4105C9M aspartyl-trna synthetase BF29_893 ENOG4105CUT histidyl-tRNA synthetase BF29_895 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BF29_896 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF29_897 ENOG4105CW7 secretion protein, HlyD family BF29_898 ENOG410834F Transcriptional regulator BF29_899 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BF29_90 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BF29_900 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BF29_901 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BF29_902 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BF29_903 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BF29_905 ENOG4105CKP Polysaccharide Biosynthesis Protein BF29_906 ENOG4108QG2 Membrane BF29_908 ENOG4105VIE preprotein translocase, subunit YajC BF29_909 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BF29_910 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) BF29_911 ENOG41061AI Protein of unknown function (DUF2905) BF29_913 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BF29_914 ENOG4105CDY transcriptional regulatory protein BF29_918 ENOG4105CQC Prephenate dehydratase BF29_919 ENOG41090I5 UPF0735 ACT domain-containing protein BF29_920 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BF29_922 ENOG4105K46 50S ribosomal protein l27 BF29_923 ENOG4105X36 (ribosomal) protein BF29_924 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BF29_925 ENOG4105C03 ribonuclease BF29_928 ENOG4107QMS site-determining protein BF29_929 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) BF29_931 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BF29_932 ENOG4105DFF Rod shape-determining protein mreb BF29_935 ENOG4105W5Q DNA repair protein (RadC BF29_937 ENOG4106A3R peptidase BF29_94 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) BF29_942 ENOG4105D7Q type ii secretion system BF29_943 ENOG4105CZX twitching motility protein BF29_944 ENOG4107QHF type ii secretion system protein e BF29_95 ENOG4108Z5K methylglyoxal synthase BF29_952 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BF29_953 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BF29_955 ENOG4106AR7 Spore coat protein BF29_956 ENOG41068KH stage VI sporulation protein D BF29_956 ENOG41068KH stage VI sporulation protein D BF29_957 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BF29_958 ENOG4105D52 delta-aminolevulinic acid dehydratase BF29_960 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BF29_962 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BF29_964 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) BF29_965 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BF29_966 ENOG4108IUQ atp-dependent protease BF29_967 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BF29_968 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BF29_97 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BF29_973 ENOG4105M59 Phosphodiesterase, mj0936 family BF29_974 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BF29_975 ENOG4108XJQ germination protein BF29_978 ENOG41067TZ transcriptional regulator, MarR family BF29_98 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF29_981 ENOG4105DQ6 Transposase BF29_985 ENOG4105PFC Transcriptional regulator BF29_987 ENOG4105E33 succinate dehydrogenase BF29_989 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BF29_99 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF29_992 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BF29_993 ENOG4105K63 Thioredoxin BF29_994 ENOG4105C10 Electron transfer flavoprotein BF29_995 ENOG4105BZJ Electron transfer flavoprotein BF29_996 ENOG41060WC Enoyl-CoA hydratase BF29_997 ENOG4107Z3H Transcriptional regulator, TetR family BF29_998 ENOG4105CEY Amp-dependent synthetase and ligase BF29_999 ENOG4105C98 muts2 protein