locus-tag	class	description
I6J17_00005	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6J17_00020	COG2010	Cytochrome c
I6J17_00025	COG2384	SAM-dependent methyltransferase
I6J17_00030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6J17_00035	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6J17_00045	COG0513	Belongs to the DEAD box helicase family
I6J17_00050	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6J17_00055	COG3883	PFAM NLP P60 protein
I6J17_00055	COG0791	NLP P60 protein
I6J17_00065	COG1121	(ABC) transporter
I6J17_00070	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J17_00075	COG0735	belongs to the Fur family
I6J17_00080	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
I6J17_00085	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6J17_00095	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6J17_00100	COG0477	Major facilitator Superfamily
I6J17_00105	COG0768	penicillin binding
I6J17_00115	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J17_00125	COG0705	Rhomboid family
I6J17_00125	COG0457	Tetratricopeptide repeat
I6J17_00130	COG4483	Protein conserved in bacteria
I6J17_00135	COG1940	carbohydrate kinase activity
I6J17_00145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J17_00160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6J17_00165	COG1459	type II secretion system
I6J17_00170	COG4537	Required for transformation and DNA binding
I6J17_00195	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6J17_00210	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6J17_00215	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6J17_00225	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6J17_00230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J17_00235	COG0095	Lipoate-protein ligase
I6J17_00240	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J17_00255	COG0183	Belongs to the thiolase family
I6J17_00280	COG3872	metal-dependent enzyme
I6J17_00290	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6J17_00295	COG0006	proline dipeptidase activity
I6J17_00300	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6J17_00305	COG3854	ATPases associated with a variety of cellular activities
I6J17_00345	COG0511	ligase activity, forming carbon-carbon bonds
I6J17_00350	COG0439	Biotin carboxylase
I6J17_00355	COG1302	Protein conserved in bacteria
I6J17_00365	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6J17_00370	COG1570	exodeoxyribonuclease VII activity
I6J17_00385	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6J17_00390	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I6J17_00400	COG0497	DNA recombination
I6J17_00405	COG0750	zinc metalloprotease
I6J17_00410	COG0745	RESPONSE REGULATOR receiver
I6J17_00415	COG0584	glycerophosphoryl diester phosphodiesterase
I6J17_00430	COG3829	transcription factor binding
I6J17_00430	COG3290	protein histidine kinase activity
I6J17_00440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J17_00445	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6J17_00450	COG0022	dehydrogenase e1 component
I6J17_00455	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J17_00460	COG1105	Belongs to the carbohydrate kinase PfkB family
I6J17_00470	COG1376	ErfK ybiS ycfS ynhG family protein
I6J17_00485	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6J17_00500	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6J17_00510	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6J17_00515	COG0300	oxidoreductase activity
I6J17_00520	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6J17_00530	COG1388	LysM domain
I6J17_00530	COG3858	chitin binding
I6J17_00535	COG1073	alpha beta
I6J17_00540	COG3853	Toxic anion resistance protein (TelA)
I6J17_00545	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
I6J17_00555	COG0667	Aldo Keto reductase
I6J17_00570	COG1379	DNA repair
I6J17_00575	COG1300	Membrane
I6J17_00580	COG0735	belongs to the Fur family
I6J17_00590	COG4974	Belongs to the 'phage' integrase family
I6J17_00595	COG1686	Belongs to the peptidase S11 family
I6J17_00610	COG1191	sigma factor activity
I6J17_00630	COG0697	spore germination
I6J17_00655	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6J17_00660	COG1686	Belongs to the peptidase S11 family
I6J17_00665	COG2715	membrane protein required for spore maturation
I6J17_00670	COG0700	Nucleoside recognition
I6J17_00675	COG1187	pseudouridine synthase activity
I6J17_00680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J17_00685	COG1333	cytochrome c biogenesis protein
I6J17_00690	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J17_00695	COG0745	RESPONSE REGULATOR receiver
I6J17_00700	COG5002	protein histidine kinase activity
I6J17_00705	COG1196	nuclear chromosome segregation
I6J17_00705	COG0741	lytic transglycosylase activity
I6J17_00705	COG0739	heme binding
I6J17_00710	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I6J17_00715	COG1141	Ferredoxin
I6J17_00730	COG0514	ATP-dependent DNA helicase (RecQ)
I6J17_00735	COG1266	CAAX protease self-immunity
I6J17_00750	COG3546	catalase activity
I6J17_00765	COG1408	metallophosphoesterase
I6J17_00775	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J17_00780	COG0492	ferredoxin-NADP+ reductase activity
I6J17_00785	COG2339	peptidase activity
I6J17_00790	COG3409	Peptidoglycan-binding domain 1 protein
I6J17_00790	COG3773	Cell wall hydrolase
I6J17_00795	COG2959	enzyme of heme biosynthesis
I6J17_00805	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6J17_00810	COG0539	negative regulation of cytoplasmic translation
I6J17_00825	COG1160	GTP binding
I6J17_00845	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6J17_00850	COG0776	regulation of translation
I6J17_00860	COG0142	geranyltranstransferase activity
I6J17_00865	COG2226	methyltransferase
I6J17_00870	COG0142	geranyltranstransferase activity
I6J17_00875	COG0105	UTP biosynthetic process
I6J17_00880	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6J17_00885	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6J17_00890	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6J17_00895	COG4401	Chorismate mutase type I
I6J17_00900	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6J17_00905	COG0287	Prephenate dehydrogenase
I6J17_00910	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6J17_00915	COG0457	Tetratricopeptide repeat
I6J17_00920	COG5582	Belongs to the UPF0302 family
I6J17_00935	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6J17_00945	COG4347	Protein of unknown function (DUF1405)
I6J17_00955	COG2738	Putative neutral zinc metallopeptidase
I6J17_00965	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6J17_00970	COG1694	Mazg nucleotide pyrophosphohydrolase
I6J17_00975	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6J17_00980	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6J17_00985	COG0438	transferase activity, transferring glycosyl groups
I6J17_01005	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6J17_01010	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6J17_01015	COG1199	ATP-dependent helicase activity
I6J17_01015	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6J17_01030	COG0017	Asparaginyl-tRNA synthetase
I6J17_01035	COG3935	DnaD domain protein
I6J17_01040	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6J17_01045	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6J17_01045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J17_01050	COG3331	DNA recombination
I6J17_01075	COG0071	Belongs to the small heat shock protein (HSP20) family
I6J17_01080	COG1205	dead DEAH box helicase
I6J17_01080	COG1111	helicase
I6J17_01085	COG3359	exonuclease
I6J17_01095	COG4474	Belongs to the UPF0398 family
I6J17_01110	COG0116	Belongs to the methyltransferase superfamily
I6J17_01115	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6J17_01125	COG2233	PERMEase
I6J17_01140	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6J17_01145	COG0789	Transcriptional regulator
I6J17_01150	COG0174	glutamine synthetase
I6J17_01155	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6J17_01165	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6J17_01170	COG4224	UPF0291 protein
I6J17_01185	COG3763	UPF0154 protein
I6J17_01190	COG0785	Cytochrome C biogenesis protein
I6J17_01195	COG2201	protein-glutamate methylesterase activity
I6J17_01200	COG4846	Membrane protein involved in cytochrome C biogenesis
I6J17_01210	COG0204	Acyl-transferase
I6J17_01215	COG2027	D-alanyl-D-alanine carboxypeptidase
I6J17_01220	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6J17_01255	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6J17_01260	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6J17_01265	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6J17_01270	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J17_01275	COG0505	Belongs to the CarA family
I6J17_01280	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6J17_01285	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J17_01290	COG0137	argininosuccinate synthase activity
I6J17_01295	COG0165	Argininosuccinate lyase
I6J17_01300	COG0436	Aminotransferase
I6J17_01330	COG0789	Transcriptional regulator
I6J17_01335	COG4990	cell redox homeostasis
I6J17_01345	COG2404	hydrolase activity, acting on ester bonds
I6J17_01350	COG1252	NADH dehydrogenase
I6J17_01360	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6J17_01365	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6J17_01370	COG0701	Predicted permease
I6J17_01380	COG0709	Synthesizes selenophosphate from selenide and ATP
I6J17_01385	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I6J17_01400	COG1028	Short-chain dehydrogenase reductase Sdr
I6J17_01410	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6J17_01440	COG1131	(ABC) transporter
I6J17_01445	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I6J17_01455	COG0783	Belongs to the Dps family
I6J17_01460	COG1914	H( )-stimulated, divalent metal cation uptake system
I6J17_01465	COG0494	nUDIX hydrolase
I6J17_01470	COG1247	-acetyltransferase
I6J17_01490	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6J17_01495	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6J17_01500	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6J17_01505	COG0297	glycogen (starch) synthase activity
I6J17_01515	COG0708	Exodeoxyribonuclease III
I6J17_01520	COG3773	Cell wall hydrolase
I6J17_01525	COG2223	nitrite transmembrane transporter activity
I6J17_01530	COG1028	Short-chain dehydrogenase reductase Sdr
I6J17_01570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J17_01575	COG0798	PFAM Bile acid sodium symporter
I6J17_01580	COG0640	Transcriptional regulator
I6J17_01615	COG0583	DNA-binding transcription factor activity
I6J17_01635	COG0589	response to stress
I6J17_01655	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J17_01655	COG0475	glutathione-regulated potassium exporter activity
I6J17_01660	COG0039	L-malate dehydrogenase activity
I6J17_01675	COG2322	membrane
I6J17_01700	COG0561	phosphatase activity
I6J17_01710	COG0318	PFAM AMP-dependent synthetase and ligase
I6J17_01715	COG0183	Belongs to the thiolase family
I6J17_01730	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6J17_01745	COG3264	Mechanosensitive ion channel
I6J17_01745	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6J17_01750	COG3284	Transcriptional regulator
I6J17_01755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J17_01760	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J17_01765	COG0022	dehydrogenase e1 component
I6J17_01770	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6J17_01775	COG0697	spore germination
I6J17_01780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J17_01805	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J17_01810	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6J17_01815	COG2045	Belongs to the ComB family
I6J17_01830	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J17_01835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J17_01850	COG1309	transcriptional regulator
I6J17_01890	COG2258	MOSC domain
I6J17_01900	COG0352	thiamine-phosphate diphosphorylase activity
I6J17_01905	COG0351	phosphomethylpyrimidine kinase
I6J17_01910	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6J17_01915	COG1028	Short-chain dehydrogenase reductase Sdr
I6J17_01925	COG0456	acetyltransferase
I6J17_01935	COG0456	acetyltransferase
I6J17_01950	COG0681	Belongs to the peptidase S26 family
I6J17_01955	COG2070	2-Nitropropane dioxygenase
I6J17_01975	COG0574	Belongs to the PEP-utilizing enzyme family
I6J17_01975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J17_01980	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6J17_01995	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J17_02000	COG0187	DNA topoisomerase II activity
I6J17_02005	COG1832	CoA-binding protein
I6J17_02010	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6J17_02015	COG4841	protein insertion into membrane
I6J17_02025	COG0824	Thioesterase
I6J17_02045	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6J17_02055	COG2309	aminopeptidase activity
I6J17_02080	COG0318	PFAM AMP-dependent synthetase and ligase
I6J17_02085	COG1346	cytolysis
I6J17_02090	COG1380	Effector of murein hydrolase LrgA
I6J17_02100	COG1132	(ABC) transporter
I6J17_02105	COG1132	(ABC) transporter
I6J17_02115	COG0477	Major facilitator Superfamily
I6J17_02125	COG1113	amino acid transport
I6J17_02130	COG0745	RESPONSE REGULATOR receiver
I6J17_02135	COG0642	Histidine kinase
I6J17_02140	COG1136	(ABC) transporter
I6J17_02145	COG0577	efflux transmembrane transporter activity
I6J17_02160	COG3634	alkyl hydroperoxide reductase activity
I6J17_02165	COG0302	gtp cyclohydrolase
I6J17_02170	COG1278	Cold shock
I6J17_02180	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J17_02190	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6J17_02195	COG2807	transmembrane transport
I6J17_02215	COG0569	domain protein
I6J17_02220	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6J17_02225	COG2962	Rard protein
I6J17_02230	COG2391	methyltransferase activity
I6J17_02240	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6J17_02240	COG0140	phosphoribosyl-ATP diphosphatase activity
I6J17_02255	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6J17_02260	COG0131	Imidazoleglycerol-phosphate dehydratase
I6J17_02270	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6J17_02275	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I6J17_02285	COG0598	Magnesium transport protein CorA
I6J17_02290	COG1113	amino acid transport
I6J17_02295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J17_02300	COG1388	LysM domain
I6J17_02300	COG3584	3D domain protein
I6J17_02310	COG0517	IMP dehydrogenase activity
I6J17_02310	COG0516	GMP reductase activity
I6J17_02315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J17_02325	COG2135	peptidase activity
I6J17_02330	COG1054	Belongs to the UPF0176 family
I6J17_02340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6J17_02360	COG1012	belongs to the aldehyde dehydrogenase family
I6J17_02365	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J17_02370	COG0567	Dehydrogenase, E1 component
I6J17_02385	COG5002	protein histidine kinase activity
I6J17_02390	COG0745	RESPONSE REGULATOR receiver
I6J17_02400	COG2814	Major facilitator Superfamily
I6J17_02405	COG1331	Highly conserved protein containing a thioredoxin domain
I6J17_02410	COG1368	sulfuric ester hydrolase activity
I6J17_02415	COG0671	phosphoesterase, PA-phosphatase related
I6J17_02420	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I6J17_02425	COG3285	dna ligase
I6J17_02425	COG1793	dna ligase
I6J17_02440	COG0534	Mate efflux family protein
I6J17_02445	COG2340	Cysteine-rich secretory protein family
I6J17_02450	COG1846	Transcriptional regulator
I6J17_02455	COG3409	Peptidoglycan-binding domain 1 protein
I6J17_02455	COG0793	Belongs to the peptidase S41A family
I6J17_02460	COG1876	peptidase activity
I6J17_02475	COG4479	Belongs to the UPF0346 family
I6J17_02480	COG0840	transmembrane signaling receptor activity
I6J17_02490	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J17_02495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J17_02500	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6J17_02500	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6J17_02510	COG2755	lipolytic protein G-D-S-L family
I6J17_02515	COG1272	protein, Hemolysin III
I6J17_02520	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6J17_02525	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6J17_02540	COG1413	lyase activity
I6J17_02545	COG0488	(ABC) transporter
I6J17_02555	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6J17_02560	COG1321	iron dependent repressor
I6J17_02585	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J17_02590	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I6J17_02595	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6J17_02600	COG0464	growth
I6J17_02610	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6J17_02630	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6J17_02635	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6J17_02645	COG4550	Control of competence regulator ComK, YlbF/YmcA
I6J17_02650	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J17_02655	COG0531	amino acid
I6J17_02660	COG0826	peptidase U32
I6J17_02665	COG0826	peptidase U32
I6J17_02670	COG2359	stage V sporulation protein S
I6J17_02675	COG1692	metallophosphoesterase
I6J17_02680	COG1418	mRNA catabolic process
I6J17_02690	COG1058	Belongs to the CinA family
I6J17_02690	COG1546	Belongs to the CinA family
I6J17_02695	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6J17_02700	COG1426	Protein conserved in bacteria
I6J17_02715	COG0300	oxidoreductase activity
I6J17_02720	COG0612	Peptidase, M16
I6J17_02725	COG0612	Peptidase, M16
I6J17_02730	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6J17_02735	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6J17_02740	COG3845	ABC transporter
I6J17_02745	COG1744	ABC transporter substrate-binding protein PnrA-like
I6J17_02750	COG1674	ftsk spoiiie
I6J17_02750	COG4980	gas vesicle protein
I6J17_02760	COG0740	serine-type endopeptidase activity
I6J17_02765	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6J17_02775	COG0527	aspartate kinase activity
I6J17_02780	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6J17_02785	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6J17_02790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J17_02795	COG1873	PFAM PRC-barrel domain
I6J17_02800	COG0612	Peptidase, M16
I6J17_02805	COG0726	polysaccharide deacetylase
I6J17_02810	COG1185	polyribonucleotide nucleotidyltransferase activity
I6J17_02815	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6J17_02820	COG0196	riboflavin kinase activity
I6J17_02825	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6J17_02830	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6J17_02835	COG1550	Protein conserved in bacteria
I6J17_02845	COG1358	cellular component organization or biogenesis
I6J17_02850	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6J17_02855	COG0195	Participates in both transcription termination and antitermination
I6J17_02860	COG0779	Required for maturation of 30S ribosomal subunits
I6J17_02865	COG2176	DNA-directed DNA polymerase activity
I6J17_02870	COG0442	prolyl-tRNA aminoacylation
I6J17_02875	COG0750	zinc metalloprotease
I6J17_02880	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6J17_02885	COG4589	Belongs to the CDS family
I6J17_02890	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J17_02895	COG0233	cytoplasmic translational termination
I6J17_02900	COG0528	UMP kinase activity
I6J17_02905	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6J17_02910	COG0052	Belongs to the universal ribosomal protein uS2 family
I6J17_02920	COG1191	sigma factor activity
I6J17_02925	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I6J17_02930	COG1776	CheC inhibitor of MCP methylation
I6J17_02935	COG0835	chemotaxis
I6J17_02940	COG2198	Histidine kinase
I6J17_02940	COG0643	Histidine kinase
I6J17_02945	COG2201	protein-glutamate methylesterase activity
I6J17_02950	COG0455	bacterial-type flagellum organization
I6J17_02955	COG1419	protein localization to endoplasmic reticulum
I6J17_02960	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6J17_02965	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6J17_02970	COG1684	flagellar biosynthetic protein fliR
I6J17_02975	COG1987	bacterial-type flagellum assembly
I6J17_02980	COG1338	Plays a role in the flagellum-specific transport system
I6J17_02985	COG3190	flagellar
I6J17_02990	COG2201	protein-glutamate methylesterase activity
I6J17_02995	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6J17_02995	COG1776	CheC inhibitor of MCP methylation
I6J17_03000	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6J17_03005	COG1580	Controls the rotational direction of flagella during chemotaxis
I6J17_03015	COG4786	Flagellar basal body rod
I6J17_03025	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6J17_03040	COG2882	bacterial-type flagellum organization
I6J17_03045	COG1157	protein secretion by the type III secretion system
I6J17_03050	COG1317	bacterial-type flagellum organization
I6J17_03055	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6J17_03060	COG1766	The M ring may be actively involved in energy transduction
I6J17_03065	COG1677	Flagellar hook-basal body complex protein FliE
I6J17_03070	COG1558	bacterial-type flagellum-dependent cell motility
I6J17_03075	COG1815	bacterial-type flagellum-dependent cell motility
I6J17_03080	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I6J17_03090	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6J17_03095	COG4974	Belongs to the 'phage' integrase family
I6J17_03100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J17_03110	COG0758	DNA mediated transformation
I6J17_03115	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6J17_03120	COG0045	succinate-CoA ligase (ADP-forming) activity
I6J17_03125	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6J17_03140	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6J17_03155	COG0336	Belongs to the RNA methyltransferase TrmD family
I6J17_03160	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6J17_03170	COG1837	Belongs to the UPF0109 family
I6J17_03180	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6J17_03185	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I6J17_03190	COG0552	protein localization to endoplasmic reticulum
I6J17_03195	COG1196	nuclear chromosome segregation
I6J17_03200	COG0571	ribonuclease III activity
I6J17_03210	COG1028	Short-chain dehydrogenase reductase Sdr
I6J17_03215	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6J17_03220	COG0416	fatty acid biosynthetic process
I6J17_03225	COG1349	DNA-binding transcription factor activity
I6J17_03230	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6J17_03235	COG1760	l-serine dehydratase
I6J17_03240	COG1760	l-serine dehydratase
I6J17_03245	COG1461	Dihydroxyacetone kinase
I6J17_03250	COG1302	Protein conserved in bacteria
I6J17_03260	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6J17_03270	COG1564	THIamine pyrophosphokinase
I6J17_03275	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6J17_03280	COG1162	GTPase activity
I6J17_03285	COG0515	serine threonine protein kinase
I6J17_03285	COG2815	serine threonine protein kinase
I6J17_03290	COG0631	protein serine/threonine phosphatase activity
I6J17_03295	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6J17_03295	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6J17_03300	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6J17_03305	COG0242	peptide deformylase activity
I6J17_03310	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6J17_03315	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6J17_03320	COG1758	RNA polymerase activity
I6J17_03325	COG0194	GDP metabolic process
I6J17_03330	COG2052	Domain of unknown function (DUF370)
I6J17_03335	COG1561	YicC-like family, N-terminal region
I6J17_03340	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6J17_03350	COG0385	Bile acid
I6J17_03365	COG0628	permease
I6J17_03370	COG0477	Major facilitator Superfamily
I6J17_03375	COG0477	Major facilitator Superfamily
I6J17_03380	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6J17_03395	COG1803	Methylglyoxal synthase
I6J17_03420	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6J17_03430	COG0167	dihydroorotate dehydrogenase activity
I6J17_03435	COG0543	2 iron, 2 sulfur cluster binding
I6J17_03450	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J17_03455	COG0540	Belongs to the ATCase OTCase family
I6J17_03460	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6J17_03465	COG0564	pseudouridine synthase activity
I6J17_03470	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6J17_03485	COG3599	regulation of cell shape
I6J17_03490	COG2302	S4 RNA-binding domain
I6J17_03495	COG0762	integral membrane protein
I6J17_03500	COG1799	cell septum assembly
I6J17_03505	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6J17_03515	COG3584	3D domain protein
I6J17_03515	COG1388	LysM domain
I6J17_03520	COG1873	PFAM PRC-barrel domain
I6J17_03525	COG1191	sigma factor activity
I6J17_03530	COG1191	sigma factor activity
I6J17_03540	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6J17_03545	COG0849	cell division
I6J17_03550	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6J17_03555	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6J17_03560	COG0772	Belongs to the SEDS family
I6J17_03565	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6J17_03570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J17_03585	COG0768	penicillin binding
I6J17_03590	COG0768	penicillin binding
I6J17_03595	COG4839	cell division protein FtsL
I6J17_03600	COG0275	rRNA processing
I6J17_03605	COG2001	Belongs to the MraZ family
I6J17_03610	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
I6J17_03615	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6J17_03620	COG0454	-acetyltransferase
I6J17_03630	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6J17_03635	COG1399	metal-binding, possibly nucleic acid-binding protein
I6J17_03640	COG1323	Belongs to the UPF0348 family
I6J17_03645	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6J17_03650	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6J17_03655	COG3314	Sporulation integral membrane protein YlbJ
I6J17_03660	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6J17_03665	COG0742	ribosomal rna small subunit methyltransferase
I6J17_03675	COG4471	UPF0298 protein
I6J17_03680	COG3679	Belongs to the UPF0342 family
I6J17_03705	COG2340	Cysteine-rich secretory protein family
I6J17_03715	COG3336	cytochrome c oxidase
I6J17_03720	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6J17_03735	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6J17_03735	COG2010	Cytochrome c
I6J17_03740	COG0109	protoheme IX farnesyltransferase activity
I6J17_03745	COG1612	heme a metabolic process
I6J17_03750	COG0772	Belongs to the SEDS family
I6J17_03755	COG4838	Belongs to the UPF0358 family
I6J17_03760	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6J17_03765	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6J17_03775	COG1217	gtp-binding protein TYPA
I6J17_03785	COG0483	inositol monophosphate 1-phosphatase activity
I6J17_03805	COG1982	Orn Lys Arg decarboxylase major
I6J17_03845	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6J17_03855	COG1473	amidohydrolase
I6J17_03860	COG2171	N-acyltransferase activity
I6J17_03865	COG0583	DNA-binding transcription factor activity
I6J17_03870	COG0517	IMP dehydrogenase activity
I6J17_03875	COG4703	Protein of unknown function (DUF1797)
I6J17_03885	COG1028	Short-chain dehydrogenase reductase Sdr
I6J17_03905	COG2409	Drug exporters of the RND superfamily
I6J17_03905	COG1033	growth of symbiont in host cell
I6J17_03915	COG0835	chemotaxis
I6J17_03915	COG0784	Response regulator, receiver
I6J17_03920	COG0436	Aminotransferase
I6J17_03925	COG2084	Dehydrogenase
I6J17_03940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J17_03950	COG4873	Protein conserved in bacteria
I6J17_03960	COG3949	Membrane
I6J17_03965	COG0542	response to heat
I6J17_03980	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J17_03985	COG5002	protein histidine kinase activity
I6J17_04000	COG0861	Integral membrane protein TerC family
I6J17_04010	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6J17_04015	COG3852	Histidine kinase
I6J17_04020	COG0673	inositol 2-dehydrogenase activity
I6J17_04025	COG0783	Belongs to the Dps family
I6J17_04030	COG0730	response to heat
I6J17_04040	COG1959	2 iron, 2 sulfur cluster binding
I6J17_04050	COG0477	Major facilitator Superfamily
I6J17_04100	COG2323	membrane
I6J17_04135	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6J17_04140	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6J17_04160	COG1522	sequence-specific DNA binding
I6J17_04165	COG2059	Chromate
I6J17_04170	COG2059	Chromate
I6J17_04175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J17_04190	COG3579	cysteine-type endopeptidase activity
I6J17_04200	COG1668	transmembrane transport
I6J17_04205	COG4152	abc transporter atp-binding protein
I6J17_04215	COG1940	carbohydrate kinase activity
I6J17_04235	COG2382	esterase
I6J17_04245	COG2153	protein acetylation
I6J17_04270	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J17_04305	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6J17_04310	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6J17_04315	COG0564	pseudouridine synthase activity
I6J17_04325	COG2357	RelA SpoT domain protein
I6J17_04335	COG4116	CYTH
I6J17_04340	COG0741	lytic transglycosylase activity
I6J17_04345	COG2346	COG2346, Truncated hemoglobins
I6J17_04350	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J17_04360	COG1164	Oligoendopeptidase f
I6J17_04365	COG4469	Competence protein
I6J17_04370	COG4862	establishment of competence for transformation
I6J17_04375	COG1393	Belongs to the ArsC family
I6J17_04380	COG4608	Belongs to the ABC transporter superfamily
I6J17_04385	COG0444	Belongs to the ABC transporter superfamily
I6J17_04390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J17_04395	COG0601	transmembrane transport
I6J17_04400	COG4166	transmembrane transport
I6J17_04415	COG0180	Tryptophanyl-tRNA synthetase
I6J17_04435	COG0601	transmembrane transport
I6J17_04440	COG4608	Belongs to the ABC transporter superfamily
I6J17_04455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J17_04460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J17_04495	COG2151	metal-sulfur cluster biosynthetic enzyme
I6J17_04500	COG0561	phosphatase activity
I6J17_04510	COG1307	EDD domain protein, DegV family
I6J17_04530	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J17_04535	COG2311	Membrane
I6J17_04570	COG1074	ATP-dependent DNA helicase activity
I6J17_04575	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I6J17_04585	COG4903	ComK protein
I6J17_04595	COG0501	Belongs to the peptidase M48B family
I6J17_04605	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6J17_04610	COG0318	PFAM AMP-dependent synthetase and ligase
I6J17_04615	COG0095	Lipoate-protein ligase
I6J17_04630	COG1999	signal sequence binding
I6J17_04640	COG0697	spore germination
I6J17_04645	COG2814	Major facilitator Superfamily
I6J17_04650	COG1511	domain protein
I6J17_04655	COG1309	transcriptional regulator
I6J17_04660	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6J17_04665	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6J17_04670	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6J17_04675	COG2329	Antibiotic biosynthesis monooxygenase
I6J17_04680	COG3069	C4-dicarboxylate transmembrane transporter activity
I6J17_04685	COG1473	amidohydrolase
I6J17_04695	COG4473	ABC transporter
I6J17_04700	COG1131	(ABC) transporter
I6J17_04705	COG0537	adenosine 5'-monophosphoramidase activity
I6J17_04725	COG1846	Transcriptional regulator
I6J17_04740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J17_04750	COG3481	metal-dependent phosphohydrolase, HD sub domain
I6J17_04755	COG4717	serine-type aminopeptidase activity
I6J17_04760	COG0420	3'-5' exonuclease activity
I6J17_04765	COG3689	TIGRFAM TIGR03943 family protein
I6J17_04770	COG0701	Predicted permease
I6J17_04775	COG0861	Integral membrane protein TerC family
I6J17_04785	COG1024	Enoyl-CoA hydratase
I6J17_04790	COG0561	phosphatase activity
I6J17_04800	COG4399	Belongs to the UPF0754 family
I6J17_04810	COG0189	ligase activity
I6J17_04815	COG0189	ligase activity
I6J17_04825	COG2508	Transcriptional regulator
I6J17_04830	COG3842	ATPase activity
I6J17_04870	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J17_04875	COG1481	regulation of sporulation
I6J17_04880	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6J17_04885	COG1660	Displays ATPase and GTPase activities
I6J17_04890	COG1051	belongs to the nudix hydrolase family
I6J17_04895	COG0492	ferredoxin-NADP+ reductase activity
I6J17_04900	COG0457	Tetratricopeptide repeat
I6J17_04905	COG0110	maltose O-acetyltransferase activity
I6J17_04910	COG0546	phosphoglycolate phosphatase activity
I6J17_04920	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I6J17_04930	COG3595	metallopeptidase activity
I6J17_04940	COG1682	transport, permease protein
I6J17_04945	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6J17_04955	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6J17_04995	COG0463	Glycosyl transferase, family 2
I6J17_05005	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6J17_05010	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J17_05015	COG0556	nucleotide-excision repair
I6J17_05040	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6J17_05045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6J17_05050	COG0581	inorganic phosphate transmembrane transporter activity
I6J17_05055	COG0573	inorganic phosphate transmembrane transporter activity
I6J17_05065	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6J17_05070	COG5002	protein histidine kinase activity
I6J17_05075	COG0745	RESPONSE REGULATOR receiver
I6J17_05095	COG4607	ABC-type enterochelin transport system periplasmic component
I6J17_05100	COG4604	ABC transporter, ATP-binding protein
I6J17_05105	COG4605	iron ion homeostasis
I6J17_05110	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J17_05115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J17_05120	COG3409	Peptidoglycan-binding domain 1 protein
I6J17_05120	COG0793	Belongs to the peptidase S41A family
I6J17_05125	COG0460	homoserine dehydrogenase
I6J17_05140	COG0739	heme binding
I6J17_05145	COG2177	Part of the ABC transporter FtsEX involved in
I6J17_05150	COG2884	Cell division ATP-binding protein ftsE
I6J17_05160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6J17_05170	COG0653	protein targeting
I6J17_05190	COG0405	Gamma-glutamyltransferase
I6J17_05205	COG1516	flagellar protein fliS
I6J17_05210	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6J17_05215	COG1334	flagellar protein FlaG
I6J17_05225	COG2094	Belongs to the DNA glycosylase MPG family
I6J17_05275	COG1067	ATP-dependent peptidase activity
I6J17_05280	COG1113	amino acid transport
I6J17_05285	COG2271	Major facilitator Superfamily
I6J17_05295	COG0647	UMP catabolic process
I6J17_05300	COG1285	pathogenesis
I6J17_05305	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I6J17_05330	COG0653	protein targeting
I6J17_05335	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6J17_05345	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6J17_05350	COG4786	Flagellar basal body rod
I6J17_05350	COG1256	bacterial-type flagellum assembly
I6J17_05360	COG2747	anti-sigma28 factor FlgM
I6J17_05370	COG1040	competence protein
I6J17_05375	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I6J17_05380	COG1307	EDD domain protein, DegV family
I6J17_05385	COG0531	amino acid
I6J17_05390	COG2197	response regulator
I6J17_05400	COG1739	Uncharacterized protein family UPF0029
I6J17_05405	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J17_05410	COG0768	penicillin binding
I6J17_05420	COG0791	NLP P60 protein
I6J17_05420	COG1388	LysM domain
I6J17_05425	COG2188	Transcriptional regulator
I6J17_05435	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6J17_05440	COG0477	Major facilitator Superfamily
I6J17_05450	COG1482	cell wall glycoprotein biosynthetic process
I6J17_05455	COG0346	lactoylglutathione lyase activity
I6J17_05460	COG2996	Protein conserved in bacteria
I6J17_05480	COG1609	Transcriptional regulator
I6J17_05485	COG2017	converts alpha-aldose to the beta-anomer
I6J17_05490	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I6J17_05495	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6J17_05510	COG1960	acyl-CoA dehydrogenase activity
I6J17_05525	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I6J17_05540	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6J17_05545	COG1090	epimerase
I6J17_05555	COG2226	methyltransferase
I6J17_05565	COG0798	PFAM Bile acid sodium symporter
I6J17_05615	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J17_05625	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6J17_05630	COG0436	Aminotransferase
I6J17_05635	COG0789	Transcriptional regulator
I6J17_05640	COG0534	Mate efflux family protein
I6J17_05645	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J17_05655	COG4717	serine-type aminopeptidase activity
I6J17_05660	COG0420	3'-5' exonuclease activity
I6J17_05675	COG0431	NADPH-dependent FMN reductase
I6J17_05700	COG0561	phosphatase activity
I6J17_05710	COG0535	radical SAM domain protein
I6J17_05725	COG0589	response to stress
I6J17_05730	COG2244	polysaccharide biosynthetic process
I6J17_05735	COG2746	aminoglycoside 3-N-acetyltransferase activity
I6J17_05740	COG1028	Short-chain dehydrogenase reductase Sdr
I6J17_05780	COG1268	BioY protein
I6J17_05785	COG0024	Methionine aminopeptidase
I6J17_05790	COG0791	NLP P60 protein
I6J17_05790	COG1388	LysM domain
I6J17_05805	COG1454	alcohol dehydrogenase
I6J17_05805	COG1012	belongs to the aldehyde dehydrogenase family
I6J17_05820	COG4145	pantothenate transmembrane transporter activity
I6J17_05830	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6J17_05835	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6J17_05845	COG0010	Belongs to the arginase family
I6J17_05850	COG0460	homoserine dehydrogenase
I6J17_05855	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6J17_05860	COG0083	homoserine kinase activity
I6J17_05865	COG1116	anion transmembrane transporter activity
I6J17_05870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J17_05875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J17_05885	COG0154	amidase activity
I6J17_05895	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6J17_05900	COG2079	MmgE PrpD family protein
I6J17_05915	COG3716	PTS system mannose fructose sorbose family IID component
I6J17_05920	COG3715	PTS system
I6J17_05930	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J17_05930	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J17_05935	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6J17_05935	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I6J17_05945	COG2706	6-phosphogluconolactonase activity
I6J17_05950	COG0011	TIGRFAM Protein of
I6J17_05965	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J17_05975	COG1388	LysM domain
I6J17_05975	COG3584	3D domain protein
I6J17_05990	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6J17_05995	COG1609	Transcriptional regulator
I6J17_06005	COG1554	hydrolase, family 65, central catalytic
I6J17_06010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J17_06015	COG2801	Transposase and inactivated derivatives
I6J17_06020	COG1316	TRANSCRIPTIONal
I6J17_06025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J17_06035	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6J17_06045	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6J17_06070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J17_06075	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6J17_06080	COG0604	alcohol dehydrogenase
I6J17_06095	COG2207	Transcriptional regulator
I6J17_06100	COG1653	transport
I6J17_06120	COG0626	cystathionine gamma-synthase activity
I6J17_06125	COG0626	cystathionine gamma-synthase activity
I6J17_06135	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6J17_06140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J17_06140	COG3711	transcriptional antiterminator
I6J17_06150	COG2723	6-phospho-beta-galactosidase activity
I6J17_06155	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6J17_06155	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6J17_06180	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6J17_06230	COG2186	Transcriptional regulator
I6J17_06235	COG1620	l-lactate permease
I6J17_06255	COG1363	Peptidase, m42
I6J17_06260	COG0737	Belongs to the 5'-nucleotidase family
I6J17_06265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J17_06315	COG0584	glycerophosphoryl diester phosphodiesterase
I6J17_06350	COG4720	Psort location CytoplasmicMembrane, score
I6J17_06365	COG2116	formate transmembrane transporter activity
I6J17_06380	COG1131	(ABC) transporter
I6J17_06400	COG1104	cysteine desulfurase activity
I6J17_06405	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6J17_06410	COG0157	Belongs to the NadC ModD family
I6J17_06420	COG0371	Dehydrogenase
I6J17_06435	COG0606	chelatase, subunit chli
I6J17_06440	COG2272	Belongs to the type-B carboxylesterase lipase family
I6J17_06445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J17_06455	COG4297	protein containing double-stranded beta helix domain
I6J17_06470	COG0110	maltose O-acetyltransferase activity
I6J17_06475	COG1510	regulation of RNA biosynthetic process
I6J17_06480	COG0517	IMP dehydrogenase activity
I6J17_06480	COG1125	glycine betaine transport
I6J17_06485	COG1174	glycine betaine transport
I6J17_06490	COG1732	Glycine betaine
I6J17_06495	COG1174	glycine betaine transport
I6J17_06510	COG1609	Transcriptional regulator
I6J17_06515	COG2814	Major facilitator Superfamily
I6J17_06540	COG2814	Major facilitator Superfamily
I6J17_06555	COG2211	Major facilitator Superfamily
I6J17_06555	COG2190	(PTS) system
I6J17_06585	COG2130	NADP-dependent
I6J17_06590	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J17_06605	COG4989	oxidoreductase activity
I6J17_06615	COG1316	TRANSCRIPTIONal
I6J17_06625	COG0531	amino acid
I6J17_06685	COG0658	competence protein
I6J17_06685	COG2333	competence protein COMEC
I6J17_06695	COG2315	Protein conserved in bacteria
I6J17_06720	COG5263	repeat protein
I6J17_06720	COG0366	Alpha amylase catalytic
I6J17_06740	COG5504	Zn-dependent protease
I6J17_06755	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6J17_06760	COG4193	domain, Protein
I6J17_06775	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6J17_06780	COG1063	alcohol dehydrogenase
I6J17_06785	COG1070	Carbohydrate kinase
I6J17_06850	COG1442	glycosyl transferase family 8
I6J17_06850	COG1216	Glycosyl transferase, family 2
I6J17_06855	COG1442	glycosyl transferase family 8
I6J17_06855	COG1216	Glycosyl transferase, family 2
I6J17_06870	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J17_06875	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6J17_06880	COG4464	protein tyrosine phosphatase activity
I6J17_06885	COG0489	protein tyrosine kinase activity
I6J17_06890	COG3944	biosynthesis protein
I6J17_06915	COG0646	methionine synthase
I6J17_06915	COG1410	methionine synthase
I6J17_06920	COG0646	methionine synthase
I6J17_06920	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6J17_06935	COG0586	Pfam SNARE associated Golgi protein
I6J17_06940	COG0586	Pfam SNARE associated Golgi protein
I6J17_06950	COG1733	regulation of RNA biosynthetic process
I6J17_06965	COG0765	amino acid transport
I6J17_06970	COG0765	amino acid transport
I6J17_06975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J17_06990	COG0628	permease
I6J17_06995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6J17_07005	COG0531	amino acid
I6J17_07010	COG0423	glycine-tRNA ligase activity
I6J17_07025	COG1902	pentaerythritol trinitrate reductase activity
I6J17_07050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J17_07055	COG1301	dicarboxylic acid transport
I6J17_07060	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6J17_07065	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6J17_07070	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6J17_07075	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I6J17_07120	COG3973	AAA domain
I6J17_07125	COG0463	Glycosyl transferase, family 2
I6J17_07130	COG2851	Citrate transporter
I6J17_07135	COG4565	transcriptional regulatory protein
I6J17_07140	COG3290	protein histidine kinase activity
I6J17_07145	COG0004	ammonium transporteR
I6J17_07150	COG1979	alcohol dehydrogenase
I6J17_07155	COG0531	amino acid
I6J17_07160	COG0247	lactate metabolic process
I6J17_07165	COG1139	Iron-sulfur cluster binding protein
I6J17_07170	COG1556	Lactate utilization protein
I6J17_07175	COG0531	amino acid
I6J17_07190	COG1177	transmembrane transport
I6J17_07195	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6J17_07200	COG3842	ATPase activity
I6J17_07210	COG0833	amino acid
I6J17_07215	COG3104	oligopeptide transport
I6J17_07220	COG1113	amino acid transport
I6J17_07230	COG0667	Aldo Keto reductase
I6J17_07235	COG5577	PFAM Coat F domain
I6J17_07240	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6J17_07245	COG1609	Transcriptional regulator
I6J17_07260	COG2848	UPF0210 protein
I6J17_07280	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6J17_07295	COG0702	epimerase
I6J17_07310	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6J17_07315	COG1216	Glycosyl transferase, family 2
I6J17_07315	COG1442	glycosyl transferase family 8
I6J17_07340	COG0697	spore germination
I6J17_07355	COG0318	PFAM AMP-dependent synthetase and ligase
I6J17_07370	COG0371	Dehydrogenase
I6J17_07380	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6J17_07400	COG0175	sulfate reduction
I6J17_07410	COG5434	Belongs to the glycosyl hydrolase 28 family
I6J17_07425	COG1012	belongs to the aldehyde dehydrogenase family
I6J17_07440	COG3226	Transcriptional regulator
I6J17_07520	COG1309	transcriptional regulator
I6J17_07530	COG1028	Short-chain dehydrogenase reductase Sdr
I6J17_07535	COG1960	acyl-CoA dehydrogenase activity
I6J17_07540	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J17_07545	COG0217	transcriptional regulatory protein
I6J17_07565	COG1120	ATPase activity
I6J17_07570	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J17_07575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J17_07580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J17_07590	COG2076	Multidrug Resistance protein
I6J17_07595	COG2076	Multidrug Resistance protein
I6J17_07610	COG1215	transferase activity, transferring glycosyl groups
I6J17_07615	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6J17_07620	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J17_07630	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J17_07640	COG2217	Heavy metal translocating P-type atpase
I6J17_07645	COG2217	Heavy metal translocating P-type atpase
I6J17_07650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J17_07655	COG0322	excinuclease ABC activity
I6J17_07660	COG0716	FMN binding
I6J17_07665	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I6J17_07675	COG1070	Carbohydrate kinase
I6J17_07685	COG2188	Transcriptional regulator
I6J17_07690	COG0366	Alpha amylase catalytic
I6J17_07695	COG1263	PTS System
I6J17_07695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J17_07700	COG2190	(PTS) system
I6J17_07705	COG1174	glycine betaine transport
I6J17_07710	COG0517	IMP dehydrogenase activity
I6J17_07710	COG1125	glycine betaine transport
I6J17_07730	COG0183	Belongs to the thiolase family
I6J17_07735	COG3425	synthase
I6J17_07780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J17_07795	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J17_07805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J17_07810	COG4856	YbbR-like protein
I6J17_07815	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I6J17_07835	COG5662	AntiSigma factor
I6J17_07865	COG0658	competence protein
I6J17_07865	COG2333	competence protein COMEC
I6J17_08015	COG5484	DNA packaging
I6J17_08025	COG3677	Transposase
I6J17_08030	COG0175	sulfate reduction
I6J17_08115	COG3723	Recombinational DNA repair protein, rece pathway
I6J17_08120	COG5377	YqaJ viral recombinase family
I6J17_08160	COG3617	BRO family, N-terminal domain
I6J17_08185	COG1525	nuclease
I6J17_08255	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6J17_08260	COG4988	ABC transporter
I6J17_08265	COG1294	oxidase, subunit
I6J17_08270	COG1271	oxidase subunit
I6J17_08280	COG0726	polysaccharide deacetylase
I6J17_08305	COG0662	Cupin 2, conserved barrel domain protein
I6J17_08320	COG2194	sulfuric ester hydrolase activity
I6J17_08330	COG0489	protein tyrosine kinase activity
I6J17_08335	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6J17_08345	COG0833	amino acid
I6J17_08350	COG0529	Catalyzes the synthesis of activated sulfate
I6J17_08355	COG2046	Belongs to the sulfate adenylyltransferase family
I6J17_08365	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6J17_08370	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6J17_08380	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6J17_08385	COG1122	ATPase activity
I6J17_08390	COG1122	ATPase activity
I6J17_08395	COG0203	ribosomal protein L17
I6J17_08400	COG0202	RNA polymerase activity
I6J17_08405	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6J17_08410	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6J17_08415	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6J17_08420	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6J17_08425	COG0563	adenylate kinase activity
I6J17_08430	COG0201	protein transport
I6J17_08435	COG0200	Binds to the 23S rRNA
I6J17_08445	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6J17_08450	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6J17_08455	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6J17_08460	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6J17_08465	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6J17_08470	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6J17_08480	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6J17_08490	COG0255	Belongs to the universal ribosomal protein uL29 family
I6J17_08495	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6J17_08500	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6J17_08510	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6J17_08515	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6J17_08535	COG0051	transcription antitermination factor activity, RNA binding
I6J17_08540	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6J17_08545	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6J17_08550	COG0049	tRNA binding
I6J17_08555	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6J17_08560	COG1358	cellular component organization or biogenesis
I6J17_08570	COG0085	RNA polymerase activity
I6J17_08575	COG2813	Specifically methylates the guanine in position
I6J17_08585	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6J17_08590	COG0081	regulation of translation
I6J17_08595	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6J17_08600	COG0250	Participates in transcription elongation, termination and antitermination
I6J17_08605	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6J17_08610	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J17_08630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J17_08640	COG0215	cysteine-tRNA ligase activity
I6J17_08645	COG1045	serine acetyltransferase
I6J17_08650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J17_08655	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6J17_08665	COG4956	integral membrane protein (PIN domain superfamily)
I6J17_08670	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6J17_08675	COG0542	response to heat
I6J17_08680	COG3869	Catalyzes the specific phosphorylation of arginine residues in
I6J17_08685	COG3880	PFAM UvrB UvrC protein
I6J17_08730	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6J17_08735	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6J17_08740	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6J17_08750	COG0590	tRNA wobble adenosine to inosine editing
I6J17_08765	COG1428	Deoxynucleoside kinase
I6J17_08770	COG1428	Deoxynucleoside kinase
I6J17_08780	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6J17_08785	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I6J17_08800	COG0517	IMP dehydrogenase activity
I6J17_08800	COG0516	GMP reductase activity
I6J17_08880	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6J17_08885	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6J17_08890	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6J17_08895	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J17_08900	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6J17_08905	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I6J17_08910	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J17_08915	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6J17_08920	COG0037	tRNA processing
I6J17_08925	COG0515	serine threonine protein kinase
I6J17_08930	COG2304	oxidoreductase activity
I6J17_08935	COG2208	phosphoserine phosphatase activity
I6J17_08945	COG1098	S1 RNA binding domain
I6J17_08965	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6J17_08970	COG3956	TIGRFAM MazG family protein
I6J17_08975	COG2244	polysaccharide biosynthetic process
I6J17_08980	COG2002	toxin-antitoxin pair type II binding
I6J17_08985	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6J17_09000	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6J17_09005	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6J17_09010	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6J17_09020	COG0251	oxidation-reduction process
I6J17_09025	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6J17_09030	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6J17_09040	COG4466	Protein conserved in bacteria
I6J17_09060	COG0084	hydrolase, TatD family'
I6J17_09070	COG2002	toxin-antitoxin pair type II binding
I6J17_09075	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6J17_09080	COG2827	Endonuclease containing a URI domain
I6J17_09085	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6J17_09090	COG4467	Involved in initiation control of chromosome replication
I6J17_09095	COG1774	PSP1 C-terminal conserved region
I6J17_09100	COG0470	DNA polymerase III
I6J17_09105	COG1728	Protein conserved in bacteria
I6J17_09110	COG3870	Protein conserved in bacteria
I6J17_09120	COG1982	Orn Lys Arg decarboxylase major
I6J17_09155	COG3437	response regulator, receiver
I6J17_09160	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J17_09165	COG0187	DNA topoisomerase II activity
I6J17_09175	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6J17_09180	COG2501	S4 domain
I6J17_09190	COG0592	DNA-directed DNA polymerase activity
I6J17_09195	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6J17_09200	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6J17_09205	COG0594	ribonuclease P activity
I6J17_09210	COG0706	membrane insertase activity
I6J17_09215	COG1847	R3H domain protein
I6J17_09220	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6J17_09225	COG0445	tRNA wobble uridine modification
I6J17_09230	COG0357	Ribosomal RNA small subunit methyltransferase G
I6J17_09235	COG1475	DNA binding
I6J17_09245	COG1192	Involved in chromosome partitioning
I6J17_09250	COG1475	DNA binding
I6J17_09255	COG1811	Na channel or pump
I6J17_09265	COG0668	transmembrane transport
I6J17_09270	COG4481	Protein conserved in bacteria
I6J17_09275	COG0012	GTP binding
I6J17_09280	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J17_09280	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J17_09285	COG0307	riboflavin synthase, alpha
I6J17_09290	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J17_09290	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J17_09295	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6J17_09300	COG0360	Binds together with S18 to 16S ribosomal RNA
I6J17_09310	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6J17_09320	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I6J17_09325	COG0359	binds to the 23S rRNA
I6J17_09330	COG0305	Participates in initiation and elongation during chromosome replication
I6J17_09335	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6J17_09350	COG0745	RESPONSE REGULATOR receiver
I6J17_09355	COG5002	protein histidine kinase activity
I6J17_09360	COG4863	YycH protein
I6J17_09365	COG4853	Protein conserved in bacteria
I6J17_09370	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6J17_09375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J17_09380	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6J17_09460	COG0579	oxidoreductase
I6J17_09495	COG1126	abc transporter atp-binding protein
I6J17_09530	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J17_09550	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6J17_09560	COG1132	(ABC) transporter
I6J17_09580	COG0584	glycerophosphoryl diester phosphodiesterase
I6J17_09600	COG3842	ATPase activity
I6J17_09620	COG0028	Belongs to the TPP enzyme family
I6J17_09630	COG2814	Major facilitator Superfamily
I6J17_09645	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6J17_09650	COG1442	glycosyl transferase family 8
I6J17_09655	COG0534	Mate efflux family protein
I6J17_09670	COG1119	ATPase activity
I6J17_09675	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6J17_09680	COG2011	ABC-type metal ion transport system permease component
I6J17_09685	COG1464	Belongs to the NlpA lipoprotein family
I6J17_09690	COG1966	Carbon starvation protein
I6J17_09695	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J17_09700	COG2966	Psort location CytoplasmicMembrane, score
I6J17_09775	COG0367	asparagine synthase
I6J17_09780	COG0583	DNA-binding transcription factor activity
I6J17_09785	COG1380	Effector of murein hydrolase LrgA
I6J17_09790	COG1346	cytolysis
I6J17_09800	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6J17_09815	COG5002	protein histidine kinase activity
I6J17_09815	COG3850	Histidine kinase
I6J17_09830	COG1737	Transcriptional regulator
I6J17_09835	COG1785	Belongs to the alkaline phosphatase family
I6J17_09840	COG0514	ATP-dependent DNA helicase (RecQ)
I6J17_09845	COG0561	phosphatase activity
I6J17_09860	COG0351	phosphomethylpyrimidine kinase
I6J17_09870	COG1473	amidohydrolase
I6J17_09880	COG4948	Mandelate Racemase Muconate Lactonizing
I6J17_09885	COG3949	Membrane
I6J17_09910	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6J17_09920	COG2363	Small membrane protein
I6J17_09950	COG3253	May function as heme-dependent peroxidase
I6J17_09955	COG0280	phosphate acetyltransferase
I6J17_09965	COG0095	Lipoate-protein ligase
I6J17_09975	COG1078	dGTPase activity
I6J17_09980	COG3465	dGTPase activity
I6J17_09990	COG1994	Peptidase M50
I6J17_10000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J17_10005	COG0010	Belongs to the arginase family
I6J17_10015	COG0018	arginyl-trna synthetase
I6J17_10020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J17_10025	COG0247	lactate metabolic process
I6J17_10025	COG2181	nitrate reductase activity
I6J17_10030	COG0183	Belongs to the thiolase family
I6J17_10035	COG1960	acyl-CoA dehydrogenase activity
I6J17_10040	COG1960	acyl-CoA dehydrogenase activity
I6J17_10045	COG1309	transcriptional regulator
I6J17_10060	COG3343	RNA polymerase activity
I6J17_10065	COG0504	CTP synthase activity
I6J17_10070	COG1725	Transcriptional regulator
I6J17_10075	COG1131	(ABC) transporter
I6J17_10100	COG2204	response regulator
I6J17_10105	COG0191	fructose-bisphosphate aldolase activity
I6J17_10110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J17_10115	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6J17_10120	COG1494	fructose-1,6-bisphosphatase
I6J17_10125	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6J17_10130	COG0254	rRNA binding
I6J17_10135	COG1435	thymidine kinase activity
I6J17_10145	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6J17_10160	COG0009	L-threonylcarbamoyladenylate synthase
I6J17_10165	COG1971	Probably functions as a manganese efflux pump
I6J17_10195	COG0840	transmembrane signaling receptor activity
I6J17_10200	COG0698	ribose 5-phosphate isomerase
I6J17_10205	COG4475	Protein of unknown function (DUF436)
I6J17_10215	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6J17_10220	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6J17_10230	COG0356	it plays a direct role in the translocation of protons across the membrane
I6J17_10235	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J17_10245	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J17_10250	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6J17_10255	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6J17_10260	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6J17_10265	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6J17_10270	COG4836	Membrane
I6J17_10280	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6J17_10285	COG2385	sporulation resulting in formation of a cellular spore
I6J17_10290	COG0739	heme binding
I6J17_10295	COG1609	Transcriptional regulator
I6J17_10300	COG1077	Cell shape determining protein MreB Mrl
I6J17_10305	COG4786	Flagellar basal body rod
I6J17_10310	COG4786	Flagellar basal body rod
I6J17_10315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6J17_10325	COG0629	single-stranded DNA binding
I6J17_10340	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6J17_10360	COG1253	flavin adenine dinucleotide binding
I6J17_10365	COG0789	Transcriptional regulator
I6J17_10370	COG1253	flavin adenine dinucleotide binding
I6J17_10380	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6J17_10385	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6J17_10395	COG1554	hydrolase, family 65, central catalytic
I6J17_10400	COG5521	maltodextrose utilization protein MalA
I6J17_10405	COG3833	ABC-type maltose transport systems, permease component
I6J17_10410	COG1175	transmembrane transport
I6J17_10415	COG2182	Extracellular solute-binding protein
I6J17_10425	COG0366	Alpha amylase catalytic
I6J17_10430	COG1609	Transcriptional regulator
I6J17_10435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J17_10440	COG1280	lysine exporter protein (LysE YggA)
I6J17_10445	COG0513	Belongs to the DEAD box helicase family
I6J17_10460	COG0705	Rhomboid family
I6J17_10465	COG0736	holo-[acyl-carrier-protein] synthase activity
I6J17_10470	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6J17_10475	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6J17_10480	COG0864	Transcriptional regulator
I6J17_10485	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6J17_10490	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J17_10495	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J17_10500	COG2172	sigma factor antagonist activity
I6J17_10505	COG2208	phosphoserine phosphatase activity
I6J17_10510	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J17_10515	COG2172	sigma factor antagonist activity
I6J17_10520	COG1191	sigma factor activity
I6J17_10525	COG2208	phosphoserine phosphatase activity
I6J17_10530	COG2183	response to ionizing radiation
I6J17_10540	COG3091	SprT-like family
I6J17_10625	COG0802	atpase or kinase
I6J17_10630	COG1214	PFAM Peptidase M22, glycoprotease
I6J17_10635	COG0456	acetyltransferase
I6J17_10640	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6J17_10645	COG0488	(ABC) transporter
I6J17_10650	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I6J17_10655	COG0805	protein transport
I6J17_10670	COG1266	CAAX protease self-immunity
I6J17_10675	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6J17_10680	COG0459	protein refolding
I6J17_10685	COG2246	polysaccharide biosynthetic process
I6J17_10690	COG0463	Glycosyl transferase, family 2
I6J17_10700	COG4948	Mandelate Racemase Muconate Lactonizing
I6J17_10705	COG1335	isochorismatase
I6J17_10710	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6J17_10715	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6J17_10720	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6J17_10720	COG0519	Catalyzes the synthesis of GMP from XMP
I6J17_10735	COG3620	sequence-specific DNA binding
I6J17_10765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J17_10770	COG1120	ATPase activity
I6J17_10790	COG1028	Short-chain dehydrogenase reductase Sdr
I6J17_10800	COG2391	methyltransferase activity
I6J17_10805	COG0425	Belongs to the sulfur carrier protein TusA family
I6J17_10825	COG1279	arginine transmembrane transporter activity
I6J17_10830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J17_10840	COG0425	Belongs to the sulfur carrier protein TusA family
I6J17_10845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J17_10865	COG1131	(ABC) transporter
I6J17_10870	COG1994	Peptidase M50
I6J17_10875	COG0535	radical SAM domain protein
I6J17_10885	COG1959	2 iron, 2 sulfur cluster binding
I6J17_10890	COG2910	NAD(P)H-binding
I6J17_10895	COG3479	Phenolic acid decarboxylase
I6J17_10900	COG1695	Transcriptional regulator
I6J17_10905	COG1725	Transcriptional regulator
I6J17_10910	COG1131	(ABC) transporter
I6J17_10920	COG3328	transposase activity
I6J17_10955	COG0471	metal ion transport
I6J17_10995	COG2814	Major facilitator Superfamily
I6J17_11000	COG1132	(ABC) transporter
I6J17_11010	COG2252	PERMEase
I6J17_11015	COG3711	transcriptional antiterminator
I6J17_11025	COG1301	dicarboxylic acid transport
I6J17_11070	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J17_11075	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
I6J17_11085	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6J17_11090	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6J17_11095	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6J17_11105	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J17_11110	COG0047	phosphoribosylformylglycinamidine synthase activity
I6J17_11115	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J17_11120	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6J17_11125	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6J17_11130	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6J17_11135	COG0138	bifunctional purine biosynthesis protein purh
I6J17_11140	COG0151	Belongs to the GarS family
I6J17_11155	COG1470	cell adhesion involved in biofilm formation
I6J17_11160	COG4496	protein, YerC YecD
I6J17_11165	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
I6J17_11170	COG0210	DNA helicase
I6J17_11175	COG3344	reverse transcriptase
I6J17_11180	COG0210	DNA helicase
I6J17_11190	COG4851	CamS sex pheromone cAM373 precursor
I6J17_11195	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6J17_11200	COG2224	Isocitrate lyase
I6J17_11205	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J17_11210	COG0154	amidase activity
I6J17_11215	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J17_11235	COG1597	lipid kinase activity
I6J17_11240	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J17_11270	COG2963	transposase activity
I6J17_11400	COG1401	restriction endodeoxyribonuclease activity
I6J17_11470	COG1064	alcohol dehydrogenase
I6J17_11480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J17_11505	COG0326	Molecular chaperone. Has ATPase activity
I6J17_11510	COG1473	amidohydrolase
I6J17_11515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J17_11520	COG0765	amino acid transport
I6J17_11525	COG1126	abc transporter atp-binding protein
I6J17_11530	COG1764	response to oxidative stress
I6J17_11535	COG2814	Major facilitator Superfamily
I6J17_11540	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6J17_11545	COG1984	allophanate hydrolase subunit 2
I6J17_11550	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6J17_11565	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I6J17_11575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6J17_11585	COG2390	Transcriptional regulator
I6J17_11595	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6J17_11600	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6J17_11610	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6J17_11620	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J17_11625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J17_11630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J17_11640	COG0431	NADPH-dependent FMN reductase
I6J17_11645	COG5583	Uncharacterized small protein (DUF2292)
I6J17_11650	COG3153	acetyltransferase
I6J17_11650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J17_11685	COG1388	LysM domain
I6J17_11685	COG0791	NLP P60 protein
I6J17_11700	COG1132	(ABC) transporter
I6J17_11705	COG1132	(ABC) transporter
I6J17_11710	COG3876	Protein conserved in bacteria
I6J17_11720	COG1472	Belongs to the glycosyl hydrolase 3 family
I6J17_11735	COG1278	Cold shock
I6J17_11740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J17_11765	COG1276	copper resistance
I6J17_11765	COG2372	response to copper ion
I6J17_11770	COG4549	nuclear export factor GLE1
I6J17_11790	COG1929	Belongs to the glycerate kinase type-1 family
I6J17_11805	COG1328	CTP reductase activity
I6J17_11820	COG1301	dicarboxylic acid transport
I6J17_11855	COG0582	viral genome integration into host DNA
I6J17_11860	COG3403	YqcI/YcgG family
I6J17_11875	COG2190	(PTS) system
I6J17_11880	COG0386	Belongs to the glutathione peroxidase family
I6J17_11885	COG1280	lysine exporter protein (LysE YggA)
I6J17_11910	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6J17_11915	COG1715	Restriction endonuclease
I6J17_11920	COG0494	nUDIX hydrolase
I6J17_11950	COG3588	fructose-bisphosphate aldolase
I6J17_11975	COG0833	amino acid
I6J17_11980	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I6J17_12000	COG3829	transcription factor binding
I6J17_12005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J17_12040	COG1683	Conserved Protein
I6J17_12080	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6J17_12085	COG0210	DNA helicase
I6J17_12090	COG2233	PERMEase
I6J17_12095	COG0730	response to heat
I6J17_12100	COG1113	amino acid transport
I6J17_12105	COG0778	Nitroreductase
I6J17_12175	COG2376	Dihydroxyacetone kinase
I6J17_12180	COG1461	Dihydroxyacetone kinase
I6J17_12185	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6J17_12190	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6J17_12195	COG0531	amino acid
I6J17_12200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J17_12225	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6J17_12230	COG2814	Major facilitator Superfamily
I6J17_12245	COG0561	phosphatase activity
I6J17_12255	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
I6J17_12260	COG0371	Dehydrogenase
I6J17_12265	COG1349	DNA-binding transcription factor activity
I6J17_12270	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J17_12270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J17_12270	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J17_12275	COG0025	NhaP-type Na H and K H
I6J17_12280	COG0166	Belongs to the GPI family
I6J17_12285	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I6J17_12290	COG1304	FMN binding
I6J17_12385	COG1518	maintenance of DNA repeat elements
I6J17_12390	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I6J17_12400	COG3620	sequence-specific DNA binding
I6J17_12415	COG0737	Belongs to the 5'-nucleotidase family
I6J17_12420	COG1737	Transcriptional regulator
I6J17_12430	COG4086	secreted protein
I6J17_12450	COG2197	response regulator
I6J17_12465	COG0288	reversible hydration of carbon dioxide
I6J17_12470	COG2226	methyltransferase
I6J17_12475	COG1854	S-ribosylhomocysteine lyase activity
I6J17_12480	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J17_12485	COG0626	cystathionine gamma-synthase activity
I6J17_12490	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6J17_12495	COG2268	Band 7 protein
I6J17_12500	COG1077	Cell shape determining protein MreB Mrl
I6J17_12505	COG1607	acyl-coa hydrolase
I6J17_12510	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6J17_12520	COG3189	MarR family transcriptional regulator
I6J17_12535	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6J17_12540	COG1360	Flagellar Motor Protein
I6J17_12550	COG0693	protein deglycase activity
I6J17_12555	COG0024	Methionine aminopeptidase
I6J17_12560	COG4840	Belongs to the UPF0435 family
I6J17_12565	COG1295	ribonuclease BN
I6J17_12570	COG0477	Major facilitator Superfamily
I6J17_12575	COG0387	Pfam Sodium calcium exchanger
I6J17_12595	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6J17_12600	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6J17_12605	COG1846	Transcriptional regulator
I6J17_12630	COG1279	arginine transmembrane transporter activity
I6J17_12635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6J17_12640	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
I6J17_12660	COG2839	Protein conserved in bacteria
I6J17_12665	COG1823	symporter activity
I6J17_12680	COG3655	Transcriptional regulator
I6J17_12720	COG2132	Multicopper oxidase
I6J17_12725	COG0252	asparaginase activity
I6J17_12730	COG3275	phosphorelay sensor kinase activity
I6J17_12735	COG3279	Response regulator of the LytR AlgR family
I6J17_12740	COG2223	nitrite transmembrane transporter activity
I6J17_12745	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6J17_12750	COG0670	Belongs to the BI1 family
I6J17_12755	COG2124	cytochrome p450
I6J17_12765	COG1366	Belongs to the anti-sigma-factor antagonist family
I6J17_12770	COG1114	Component of the transport system for branched-chain amino acids
I6J17_12775	COG0129	dihydroxy-acid dehydratase activity
I6J17_12780	COG0028	Belongs to the TPP enzyme family
I6J17_12785	COG0440	acetolactate synthase activity
I6J17_12790	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6J17_12795	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J17_12805	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6J17_12810	COG0066	3-isopropylmalate dehydratase activity
I6J17_12815	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J17_12830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J17_12835	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6J17_12840	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6J17_12845	COG0840	transmembrane signaling receptor activity
I6J17_12850	COG0058	SHG alpha-glucan phosphorylase activity
I6J17_12865	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J17_12865	COG0512	Glutamine amidotransferase of anthranilate synthase
I6J17_12870	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J17_12875	COG0134	indole-3-glycerol-phosphate synthase activity
I6J17_12880	COG0133	tryptophan synthase activity
I6J17_12890	COG0159	tryptophan synthase activity
I6J17_12905	COG2137	regulation of response to DNA damage stimulus
I6J17_12920	COG1988	membrane-bound metal-dependent
I6J17_12925	COG1194	a g-specific adenine glycosylase
I6J17_12930	COG0493	'glutamate synthase
I6J17_12935	COG0070	glutamate synthase
I6J17_12935	COG0067	glutamate synthase
I6J17_12935	COG0069	glutamate synthase activity
I6J17_12940	COG0583	DNA-binding transcription factor activity
I6J17_12945	COG1028	Short-chain dehydrogenase reductase Sdr
I6J17_12960	COG3557	Belongs to the UPF0374 family
I6J17_12965	COG1132	(ABC) transporter
I6J17_13010	COG0579	oxidoreductase
I6J17_13040	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6J17_13045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J17_13045	COG1263	PTS System
I6J17_13050	COG1737	Transcriptional regulator
I6J17_13055	COG4129	membrane
I6J17_13065	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6J17_13080	COG0735	belongs to the Fur family
I6J17_13085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J17_13090	COG0583	DNA-binding transcription factor activity
I6J17_13095	COG0028	Belongs to the TPP enzyme family
I6J17_13100	COG3527	Alpha-acetolactate decarboxylase
I6J17_13210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J17_13235	COG1131	(ABC) transporter
I6J17_13250	COG0431	NADPH-dependent FMN reductase
I6J17_13255	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6J17_13260	COG1882	Formate acetyltransferase
I6J17_13270	COG2116	formate transmembrane transporter activity
I6J17_13280	COG0765	amino acid transport
I6J17_13285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J17_13290	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
I6J17_13300	COG2095	MarC family integral membrane protein
I6J17_13315	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6J17_13325	COG2766	serine protein kinase
I6J17_13330	COG2718	Belongs to the UPF0229 family
I6J17_13345	COG0306	phosphate transporter
I6J17_13350	COG1392	Phosphate transport regulator
I6J17_13375	COG3594	Acyltransferase
I6J17_13380	COG2719	SpoVR family
I6J17_13390	COG0598	Magnesium transport protein CorA
I6J17_13395	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6J17_13400	COG0601	transmembrane transport
I6J17_13405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J17_13410	COG0444	Belongs to the ABC transporter superfamily
I6J17_13415	COG4166	transmembrane transport
I6J17_13420	COG0791	NLP P60 protein
I6J17_13425	COG4608	Belongs to the ABC transporter superfamily
I6J17_13440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J17_13455	COG3383	formate dehydrogenase (NAD+) activity
I6J17_13475	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6J17_13495	COG0126	phosphoglycerate kinase activity
I6J17_13505	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6J17_13510	COG0148	phosphopyruvate hydratase activity
I6J17_13515	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6J17_13525	COG0557	exoribonuclease II activity
I6J17_13530	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6J17_13595	COG0488	(ABC) transporter
I6J17_13620	COG0800	Aldolase
I6J17_13630	COG0246	Mannitol dehydrogenase
I6J17_13635	COG2721	sulfolactate sulfo-lyase activity
I6J17_13640	COG1904	glucuronate isomerase
I6J17_13645	COG2211	Major facilitator Superfamily
I6J17_13650	COG1028	Short-chain dehydrogenase reductase Sdr
I6J17_13655	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
I6J17_13665	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6J17_13680	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6J17_13685	COG1595	DNA-templated transcription, initiation
I6J17_13700	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6J17_13710	COG0671	phosphoesterase, PA-phosphatase related
I6J17_13715	COG0753	catalase activity
I6J17_13725	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J17_13750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J17_13755	COG0772	Belongs to the SEDS family
I6J17_13760	COG5577	PFAM Coat F domain
I6J17_13775	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J17_13775	COG1024	Enoyl-CoA hydratase
I6J17_13780	COG0183	Belongs to the thiolase family
I6J17_13785	COG1960	acyl-CoA dehydrogenase activity
I6J17_13790	COG1393	Belongs to the ArsC family
I6J17_13795	COG0509	glycine decarboxylation via glycine cleavage system
I6J17_13800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J17_13810	COG0396	ATPase activity
I6J17_13815	COG0719	Fe-S assembly protein
I6J17_13820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6J17_13825	COG0822	iron-sulfur transferase activity
I6J17_13830	COG0719	Fe-S assembly protein
I6J17_13835	COG0737	Belongs to the 5'-nucleotidase family
I6J17_13840	COG3377	Domain of unknown function (DUF1805)
I6J17_13850	COG0739	heme binding
I6J17_13855	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6J17_13860	COG4470	Protein conserved in bacteria
I6J17_13865	COG2445	Protein of unknown function DUF86
I6J17_13870	COG0647	UMP catabolic process
I6J17_13875	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6J17_13880	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6J17_13885	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6J17_13900	COG4837	Protein of unknown function (DUF1462)
I6J17_13905	COG0316	Belongs to the HesB IscA family
I6J17_13945	COG0726	polysaccharide deacetylase
I6J17_13960	COG0492	ferredoxin-NADP+ reductase activity
I6J17_13965	COG1252	NADH dehydrogenase
I6J17_13975	COG3584	3D domain protein
I6J17_13980	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6J17_13990	COG0697	spore germination
I6J17_14000	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6J17_14010	COG2050	protein possibly involved in aromatic compounds catabolism
I6J17_14015	COG2814	Major facilitator Superfamily
I6J17_14065	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6J17_14085	COG0656	L-ascorbic acid biosynthetic process
I6J17_14090	COG1902	pentaerythritol trinitrate reductase activity
I6J17_14100	COG1098	S1 RNA binding domain
I6J17_14110	COG2155	Conserved Protein
I6J17_14120	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J17_14140	COG1012	belongs to the aldehyde dehydrogenase family
I6J17_14155	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
I6J17_14160	COG1028	Short-chain dehydrogenase reductase Sdr
I6J17_14185	COG2190	(PTS) system
I6J17_14190	COG1525	nuclease
I6J17_14195	COG1937	Protein conserved in bacteria
I6J17_14200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J17_14210	COG0038	chloride channel
I6J17_14240	COG0726	polysaccharide deacetylase
I6J17_14255	COG1388	LysM domain
I6J17_14260	COG0745	RESPONSE REGULATOR receiver
I6J17_14265	COG5002	protein histidine kinase activity
I6J17_14295	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J17_14315	COG1522	sequence-specific DNA binding
I6J17_14325	COG2608	mercury ion transmembrane transporter activity
I6J17_14330	COG2217	Heavy metal translocating P-type atpase
I6J17_14345	COG1285	pathogenesis
I6J17_14490	COG1575	Belongs to the MenA family. Type 1 subfamily
I6J17_14495	COG1169	isochorismate synthase
I6J17_14500	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6J17_14505	COG0596	Alpha beta hydrolase
I6J17_14510	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6J17_14515	COG0318	PFAM AMP-dependent synthetase and ligase
I6J17_14520	COG4948	Mandelate Racemase Muconate Lactonizing
I6J17_14530	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6J17_14540	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6J17_14545	COG0783	Belongs to the Dps family
I6J17_14560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J17_14565	COG1116	anion transmembrane transporter activity
I6J17_14570	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J17_14580	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6J17_14585	COG1506	peptidase
I6J17_14610	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6J17_14615	COG0367	asparagine synthase
I6J17_14620	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6J17_14625	COG2267	carboxylic ester hydrolase activity
I6J17_14635	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6J17_14645	COG2814	Major facilitator Superfamily
I6J17_14650	COG0495	leucyl-tRNA aminoacylation
I6J17_14665	COG2244	polysaccharide biosynthetic process
I6J17_14670	COG1349	DNA-binding transcription factor activity
I6J17_14675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J17_14705	COG0510	thiamine kinase activity
I6J17_14715	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6J17_14720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J17_14725	COG5584	Small secreted protein
I6J17_14730	COG0784	Response regulator, receiver
I6J17_14730	COG5002	protein histidine kinase activity
I6J17_14735	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6J17_14740	COG2208	phosphoserine phosphatase activity
I6J17_14745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J17_14750	COG4848	Belongs to the UPF0354 family
I6J17_14755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J17_14765	COG1674	ftsk spoiiie
I6J17_14770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J17_14780	COG4980	gas vesicle protein
I6J17_14785	COG1605	Chorismate mutase
I6J17_14785	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I6J17_14795	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6J17_14800	COG0517	IMP dehydrogenase activity
I6J17_14805	COG0454	-acetyltransferase
I6J17_14810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J17_14820	COG4149	molybdate abc transporter
I6J17_14825	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6J17_14830	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6J17_14845	COG0303	'Molybdopterin
I6J17_14850	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6J17_14855	COG0314	molybdopterin synthase activity
I6J17_14860	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6J17_14865	COG0315	cyclic pyranopterin monophosphate synthase activity
I6J17_14870	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6J17_14875	COG2427	Protein of unknown function (DUF1641)
I6J17_14880	COG3383	formate dehydrogenase (NAD+) activity
I6J17_14885	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6J17_14900	COG3829	transcription factor binding
I6J17_14900	COG3290	protein histidine kinase activity
I6J17_14905	COG1012	belongs to the aldehyde dehydrogenase family
I6J17_14910	COG0506	proline dehydrogenase activity
I6J17_14925	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6J17_14930	COG2199	diguanylate cyclase activity
I6J17_14930	COG2203	Gaf domain
I6J17_14935	COG1956	GAF domain-containing protein
I6J17_14940	COG1309	transcriptional regulator
I6J17_14945	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I6J17_14950	COG1104	cysteine desulfurase activity
I6J17_14955	COG0301	tRNA thio-modification
I6J17_14965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J17_14970	COG0616	signal peptide processing
I6J17_14975	COG1714	RDD family
I6J17_14985	COG3874	Sporulation protein YtfJ
I6J17_14990	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6J17_14995	COG0827	DNA restriction-modification system
I6J17_15000	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6J17_15010	COG0589	response to stress
I6J17_15020	COG0006	proline dipeptidase activity
I6J17_15025	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6J17_15030	COG4109	DRTGG domain
I6J17_15040	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6J17_15055	COG0587	DNA-directed DNA polymerase activity
I6J17_15060	COG0281	malic enzyme
I6J17_15065	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6J17_15070	COG0825	malonyl-CoA metabolic process
I6J17_15075	COG0205	6-phosphofructokinase activity
I6J17_15085	COG0628	permease
I6J17_15090	COG2707	UPF0756 membrane protein
I6J17_15095	COG0372	Belongs to the citrate synthase family
I6J17_15100	COG0538	isocitrate dehydrogenase activity
I6J17_15105	COG0039	L-malate dehydrogenase activity
I6J17_15115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J17_15115	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J17_15120	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J17_15125	COG1971	Probably functions as a manganese efflux pump
I6J17_15130	COG0237	dephospho-CoA kinase activity
I6J17_15135	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6J17_15145	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6J17_15150	COG3611	Membrane attachment protein
I6J17_15155	COG1484	DNA-dependent DNA replication
I6J17_15165	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6J17_15175	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6J17_15185	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6J17_15200	COG1363	Peptidase, m42
I6J17_15205	COG0431	NADPH-dependent FMN reductase
I6J17_15225	COG1695	Transcriptional regulator
I6J17_15260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J17_15265	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6J17_15270	COG0072	phenylalanine-tRNA ligase activity
I6J17_15270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J17_15290	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I6J17_15295	COG1286	toxin biosynthetic process
I6J17_15300	COG1796	DNA polymerase
I6J17_15300	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6J17_15305	COG1193	negative regulation of DNA recombination
I6J17_15310	COG0318	PFAM AMP-dependent synthetase and ligase
I6J17_15315	COG1309	transcriptional regulator
I6J17_15320	COG1024	Enoyl-CoA hydratase
I6J17_15325	COG2086	electron transfer activity
I6J17_15330	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6J17_15335	COG3118	belongs to the thioredoxin family
I6J17_15340	COG0322	excinuclease ABC activity
I6J17_15350	COG1719	4-vinyl reductase, 4VR
I6J17_15355	COG2009	succinate dehydrogenase
I6J17_15360	COG1053	succinate dehydrogenase
I6J17_15365	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J17_15370	COG0824	Thioesterase
I6J17_15380	COG2197	response regulator
I6J17_15410	COG1846	Transcriptional regulator
I6J17_15420	COG5401	PFAM Sporulation and spore germination
I6J17_15425	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6J17_15430	COG0622	Phosphoesterase
I6J17_15450	COG0457	Tetratricopeptide repeat
I6J17_15450	COG1477	protein flavinylation
I6J17_15455	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6J17_15465	COG1067	ATP-dependent peptidase activity
I6J17_15465	COG0470	DNA polymerase III
I6J17_15470	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6J17_15475	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6J17_15490	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6J17_15495	COG0181	hydroxymethylbilane synthase activity
I6J17_15505	COG0113	porphobilinogen synthase activity
I6J17_15510	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6J17_15515	COG1388	LysM domain
I6J17_15515	COG1388	LysM domain
I6J17_15520	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6J17_15530	COG0525	valine-tRNA ligase activity
I6J17_15535	COG0285	dihydrofolate synthase activity
I6J17_15580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6J17_15590	COG1459	type II secretion system
I6J17_15615	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6J17_15625	COG2003	Belongs to the UPF0758 family
I6J17_15635	COG2003	Belongs to the UPF0758 family
I6J17_15640	COG1077	Cell shape determining protein MreB Mrl
I6J17_15645	COG1792	Involved in formation and maintenance of cell shape
I6J17_15655	COG0850	regulation of cytokinetic process
I6J17_15660	COG2894	cell division
I6J17_15670	COG1994	Peptidase M50
I6J17_15675	COG1530	ribonuclease E activity
I6J17_15680	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6J17_15685	COG2868	ribosomal protein
I6J17_15690	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6J17_15695	COG3290	protein histidine kinase activity
I6J17_15700	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6J17_15705	COG4492	Belongs to the UPF0735 family
I6J17_15710	COG0077	Prephenate dehydratase
I6J17_15715	COG1827	regulation of RNA biosynthetic process
I6J17_15720	COG1388	LysM domain
I6J17_15730	COG0217	transcriptional regulatory protein
I6J17_15735	COG0632	four-way junction helicase activity
I6J17_15750	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6J17_15755	COG0343	queuine tRNA-ribosyltransferase activity
I6J17_15760	COG1862	Preprotein translocase
I6J17_15770	COG2323	membrane
I6J17_15775	COG2244	polysaccharide biosynthetic process
I6J17_15785	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J17_15785	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J17_15790	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6J17_15790	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6J17_15795	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6J17_15800	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J17_15805	COG1490	D-aminoacyl-tRNA deacylase activity
I6J17_15810	COG1846	Transcriptional regulator
I6J17_15815	COG1566	PFAM secretion protein HlyD family protein
I6J17_15820	COG2814	Major facilitator Superfamily
I6J17_15825	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6J17_15825	COG3103	Sh3 type 3 domain protein
I6J17_15825	COG4991	sh3 domain protein
I6J17_15835	COG0124	histidyl-tRNA synthetase
I6J17_15840	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6J17_15850	COG0385	Bile acid
I6J17_15855	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6J17_15860	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6J17_15870	COG1028	Short-chain dehydrogenase reductase Sdr
I6J17_15895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J17_15910	COG0785	Cytochrome C biogenesis protein
I6J17_15920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J17_15940	COG1937	Protein conserved in bacteria
I6J17_15945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J17_15950	COG0425	Belongs to the sulfur carrier protein TusA family
I6J17_15950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J17_15955	COG2210	Belongs to the sulfur carrier protein TusA family
I6J17_15960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J17_15960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J17_15965	COG0425	Belongs to the sulfur carrier protein TusA family
I6J17_15970	COG0730	response to heat
I6J17_15975	COG0697	spore germination
I6J17_15990	COG1959	2 iron, 2 sulfur cluster binding
I6J17_15995	COG1104	cysteine desulfurase activity
I6J17_16000	COG0482	sulfurtransferase activity
I6J17_16005	COG0457	Tetratricopeptide repeat
I6J17_16005	COG1477	protein flavinylation
I6J17_16010	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J17_16035	COG0628	permease
I6J17_16040	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6J17_16045	COG4472	Bacterial protein of unknown function (DUF965)
I6J17_16050	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6J17_16055	COG3906	Belongs to the UPF0473 family
I6J17_16060	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6J17_16065	COG4122	O-methyltransferase activity
I6J17_16070	COG0572	uridine kinase
I6J17_16075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6J17_16090	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6J17_16105	COG0450	alkyl hydroperoxide reductase
I6J17_16110	COG3634	alkyl hydroperoxide reductase activity
I6J17_16120	COG1183	phosphatidylcholine synthase activity
I6J17_16170	COG1704	LemA family
I6J17_16180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J17_16190	COG0071	Belongs to the small heat shock protein (HSP20) family
I6J17_16195	COG2132	Multicopper oxidase
I6J17_16200	COG3835	regulator
I6J17_16205	COG0277	FAD linked oxidase domain protein
I6J17_16210	COG0247	lactate metabolic process
I6J17_16215	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I6J17_16220	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6J17_16230	COG1534	Rna-binding protein
I6J17_16235	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6J17_16240	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6J17_16245	COG0799	negative regulation of ribosome biogenesis
I6J17_16250	COG2226	methyltransferase
I6J17_16255	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6J17_16260	COG1596	polysaccharide export
I6J17_16260	COG1555	photosystem II stabilization
I6J17_16265	COG2131	deaminase
I6J17_16270	COG0658	competence protein
I6J17_16270	COG2333	competence protein COMEC
I6J17_16280	COG1466	dna polymerase III delta subunit
I6J17_16285	COG0268	Binds directly to 16S ribosomal RNA
I6J17_16290	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6J17_16295	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6J17_16300	COG0481	GTPase activity
I6J17_16305	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J17_16315	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6J17_16320	COG0443	Heat shock 70 kDa protein
I6J17_16330	COG2264	protein methyltransferase activity
I6J17_16335	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6J17_16340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6J17_16345	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6J17_16350	COG1254	Belongs to the acylphosphatase family
I6J17_16360	COG1610	YqeY-like protein
I6J17_16375	COG1702	phosphate starvation-inducible protein PhoH
I6J17_16385	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6J17_16390	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6J17_16395	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6J17_16405	COG1381	Involved in DNA repair and RecF pathway recombination
I6J17_16415	COG0517	IMP dehydrogenase activity
I6J17_16425	COG0358	DNA primase activity