locus-tag class description SB48_HM08orf00002 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) SB48_HM08orf00004 ENOG4105VG0 50S ribosomal protein l34 SB48_HM08orf00005 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) SB48_HM08orf00006 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins SB48_HM08orf00010 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) SB48_HM08orf00012 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) SB48_HM08orf00014 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) SB48_HM08orf00016 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) SB48_HM08orf00019 ENOG4107QJE Chromosome Partitioning Protein SB48_HM08orf00020 ENOG4105FA0 parb-like partition protein SB48_HM08orf00025 ENOG4108ZDA Sporulation protein YyaC SB48_HM08orf00028 ENOG4105D8X mechanosensitive ion channel SB48_HM08orf00029 ENOG4105VDK protein, conserved in bacteria SB48_HM08orf00030 ENOG4105C3G gtp-binding protein SB48_HM08orf00031 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) SB48_HM08orf00032 ENOG4108R6K riboflavin synthase, subunit alpha SB48_HM08orf00034 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) SB48_HM08orf00035 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) SB48_HM08orf00037 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) SB48_HM08orf00038 ENOG4108UUM single-stranded DNA-binding protein SB48_HM08orf00039 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) SB48_HM08orf00042 ENOG4105BZR domain protein SB48_HM08orf00043 ENOG4105K9Q Binds to the 23S rRNA (By similarity) SB48_HM08orf00047 ENOG4105CDU Replicative dna helicase SB48_HM08orf00050 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis SB48_HM08orf00053 ENOG4105CK6 Two component transcriptional regulator (Winged helix family SB48_HM08orf00054 ENOG4105BZU Histidine kinase SB48_HM08orf00057 ENOG4105Q2H domain protein SB48_HM08orf00059 ENOG4105C0H protease SB48_HM08orf00062 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) SB48_HM08orf00068 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family SB48_HM08orf00073 ENOG4108NIW Leucine export protein LeuE SB48_HM08orf00085 ENOG4105D5G Transposase SB48_HM08orf00087 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) SB48_HM08orf00095 ENOG4105CVR type I restriction-modification system SB48_HM08orf00096 ENOG4105EKX Restriction modification system DNA (Specificity SB48_HM08orf00097 ENOG4105DZR Type I site-specific deoxyribonuclease SB48_HM08orf00098 ENOG4105DWT malate dehydrogenase (quinone) SB48_HM08orf00102 ENOG4105E5Q amino acid AbC transporter SB48_HM08orf00104 ENOG4105CDA abc transporter atp-binding protein SB48_HM08orf00109 ENOG4106M28 alanine racemase domain protein SB48_HM08orf00118 ENOG4105CDA abc transporter atp-binding protein SB48_HM08orf00120 ENOG4105E5Q amino acid AbC transporter SB48_HM08orf00122 ENOG4105EAB amino acid AbC transporter SB48_HM08orf00124 ENOG4107QRI Phosphoketolase SB48_HM08orf00125 ENOG4108TZY GntR Family Transcriptional Regulator SB48_HM08orf00134 ENOG4105EYF MMPL domain protein SB48_HM08orf00136 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) SB48_HM08orf00140 ENOG4105BZ1 (ABC) transporter SB48_HM08orf00142 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) SB48_HM08orf00145 ENOG4105C7K acetolactate synthase SB48_HM08orf00150 ENOG4105C0R drug resistance transporter emrb qaca subfamily SB48_HM08orf00156 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) SB48_HM08orf00157 ENOG4105X1N Glycosyl transferase family 8 SB48_HM08orf00160 ENOG4105UQX Mate efflux family protein SB48_HM08orf00165 ENOG4105DKW ABC transporter SB48_HM08orf00168 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) SB48_HM08orf00170 ENOG4108UMI ABC transporter, permease SB48_HM08orf00171 ENOG4105D01 (LipO)protein SB48_HM08orf00172 ENOG4108HRK Histidine kinase SB48_HM08orf00173 ENOG4108NEV two component transcriptional regulator, LytTR family SB48_HM08orf00177 ENOG4105CM2 brancheD-chain amino acid aminotransferase SB48_HM08orf00179 ENOG4105DWK Membrane SB48_HM08orf00190 ENOG4105CAQ asparagine synthetase SB48_HM08orf00192 ENOG4105CMU LysR family (Transcriptional regulator SB48_HM08orf00193 ENOG4105VAW lrga family SB48_HM08orf00194 ENOG41067MG lrgb family SB48_HM08orf00198 ENOG4108Z66 YbaK ebsC protein SB48_HM08orf00203 ENOG4106KNT transcriptional regulator SB48_HM08orf00205 ENOG4105G6Z alkaline phosphatase SB48_HM08orf00207 ENOG4105C9U ATP-dependent DNA helicase RecQ SB48_HM08orf00208 ENOG410667J hydrolase SB48_HM08orf00209 ENOG4108TN2 lmbE family SB48_HM08orf00214 ENOG4105DWF phosphomethylpyrimidine kinase SB48_HM08orf00222 ENOG4108IUW ABC transporter SB48_HM08orf00226 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) SB48_HM08orf00234 ENOG4107JTW chlorite dismutase SB48_HM08orf00237 ENOG4108IJ2 phosphate acetyltransferase SB48_HM08orf00245 ENOG4108VCI transcription factor, rsfa family SB48_HM08orf00247 ENOG4105DCI Phosphohydrolase SB48_HM08orf00249 ENOG41069HH 4-oxalocrotonate tautomerase SB48_HM08orf00251 ENOG4108Z4T Peptidase M50 SB48_HM08orf00253 ENOG4108XFG YwhD family SB48_HM08orf00256 ENOG4105BZ4 penicillin-binding protein SB48_HM08orf00258 ENOG4105CYW agmatinase SB48_HM08orf00261 ENOG4105C75 arginyL-tRNA synthetase SB48_HM08orf00266 ENOG4105DF6 Fe-S oxidoreductase SB48_HM08orf00273 ENOG4105C1G acyl-Coa dehydrogenase SB48_HM08orf00274 ENOG4105C1G acyl-Coa dehydrogenase SB48_HM08orf00276 ENOG4107Z3H Transcriptional regulator, TetR family SB48_HM08orf00279 ENOG4105D5P Methylmalonyl-coA mutase SB48_HM08orf00283 ENOG4105C19 ABC transporter SB48_HM08orf00288 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) SB48_HM08orf00291 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family SB48_HM08orf00293 ENOG4105CZV ABC transporter SB48_HM08orf00296 ENOG410812K response regulator receiver protein SB48_HM08orf00298 ENOG4105D2N Aldolase SB48_HM08orf00301 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) SB48_HM08orf00305 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) SB48_HM08orf00306 ENOG4105CBT Fructose-1,6-bisphosphatase SB48_HM08orf00310 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) SB48_HM08orf00313 ENOG4107104 thymidine kinase SB48_HM08orf00315 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) SB48_HM08orf00316 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) SB48_HM08orf00320 ENOG4108ZXQ stage ii sporulation protein r SB48_HM08orf00323 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) SB48_HM08orf00326 ENOG410815N Probably functions as a manganese efflux pump (By similarity) SB48_HM08orf00329 ENOG4108W2P Methyl-accepting chemotaxis SB48_HM08orf00332 ENOG4108YZG isomerase SB48_HM08orf00337 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) SB48_HM08orf00339 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) SB48_HM08orf00342 ENOG41062M3 atp synthase SB48_HM08orf00343 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) SB48_HM08orf00344 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) SB48_HM08orf00346 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) SB48_HM08orf00347 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) SB48_HM08orf00348 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) SB48_HM08orf00350 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) SB48_HM08orf00352 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) SB48_HM08orf00354 ENOG4106778 Protein of unknown function (DUF1146) SB48_HM08orf00358 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) SB48_HM08orf00362 ENOG4105FRN stage II sporulation protein SB48_HM08orf00364 ENOG4105MT0 Sporulation transcriptional regulator spoiiid SB48_HM08orf00366 ENOG4105DFF Rod shape-determining protein mreb SB48_HM08orf00370 ENOG4105CGA flagellar basal-body rod protein FlgG SB48_HM08orf00373 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) SB48_HM08orf00378 ENOG4105Z8H single-stranded DNA-binding protein SB48_HM08orf00381 ENOG4105C0D helicase SB48_HM08orf00390 ENOG4105C37 (CBS) domain SB48_HM08orf00393 ENOG4105C37 (CBS) domain SB48_HM08orf00398 ENOG4105CPF Cell wall formation (By similarity) SB48_HM08orf00399 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) SB48_HM08orf00403 ENOG4105CG3 alpha amylase, catalytic region SB48_HM08orf00405 ENOG4108VP7 maltodextrose utilization protein MalA SB48_HM08orf00407 ENOG4105EG2 ABC transporter, permease SB48_HM08orf00408 ENOG4105D56 permease protein SB48_HM08orf00412 ENOG4107FKK extracellular solute-binding protein family 1 SB48_HM08orf00413 ENOG4108IUK alpha amylase, catalytic SB48_HM08orf00414 ENOG4105CG3 alpha amylase, catalytic region SB48_HM08orf00417 ENOG4105FKQ transcriptional regulator SB48_HM08orf00418 ENOG4107URF beta-phospho-glucomutase SB48_HM08orf00426 ENOG4105C1J atp-dependent rna helicase SB48_HM08orf00430 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) SB48_HM08orf00431 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein SB48_HM08orf00437 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) SB48_HM08orf00443 ENOG4107MMM Anti-sigma-factor antagonist SB48_HM08orf00444 ENOG4105FUA antagonist SB48_HM08orf00445 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase SB48_HM08orf00448 ENOG4107SGM protein serine threonine phosphatase SB48_HM08orf00449 ENOG4105WN5 stage II sporulation protein SB48_HM08orf00451 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) SB48_HM08orf00453 ENOG41064BQ Phosphatase SB48_HM08orf00460 ENOG410906U SprT-like SB48_HM08orf00465 ENOG4105K8N protein family UPF0079, ATPase SB48_HM08orf00466 ENOG41072GX Peptidase M22 Glycoprotease SB48_HM08orf00468 ENOG410801F ribosomal-protein-alanine acetyltransferase SB48_HM08orf00470 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) SB48_HM08orf00474 ENOG4105C5H ABC transporter SB48_HM08orf00476 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) SB48_HM08orf00480 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) SB48_HM08orf00484 ENOG4108TYN CAAX amino terminal protease family protein SB48_HM08orf00488 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) SB48_HM08orf00490 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) SB48_HM08orf00498 ENOG4105DTQ mandelate racemase muconate lactonizing SB48_HM08orf00501 ENOG4105DAP Nicotinate phosphoribosyltransferase SB48_HM08orf00503 ENOG4107RA1 nh(3)-dependent nad( ) synthetase SB48_HM08orf00506 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) SB48_HM08orf00509 ENOG41067QW Transcriptional regulator SB48_HM08orf00512 ENOG4105EHG Permease protein SB48_HM08orf00513 ENOG4105E0A ABC, transporter SB48_HM08orf00519 ENOG4105CYX Short-chain dehydrogenase reductase Sdr SB48_HM08orf00522 ENOG4107QKS N-acylglucosamine 2-epimerase SB48_HM08orf00523 ENOG4105CUC YeeE YedE family protein SB48_HM08orf00532 ENOG4108Z40 Transcriptional regulator SB48_HM08orf00533 ENOG4108RYK Nad-dependent epimerase dehydratase SB48_HM08orf00536 ENOG4105PY6 Phenolic acid decarboxylase SB48_HM08orf00537 ENOG4105U3E Transcriptional regulator SB48_HM08orf00539 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family SB48_HM08orf00540 ENOG4105CZV ABC transporter SB48_HM08orf00548 ENOG4107QPK )-transporter SB48_HM08orf00552 ENOG4105ERH Fumarylacetoacetate hydrolase SB48_HM08orf00558 ENOG4105D2S major facilitator superfamily SB48_HM08orf00559 ENOG4105G9B Transcriptional regulator SB48_HM08orf00561 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase SB48_HM08orf00566 ENOG4105CHU acetyl-coa acetyltransferase SB48_HM08orf00569 ENOG4105CEY Amp-dependent synthetase and ligase SB48_HM08orf00570 ENOG41082UD thioesterase Superfamily protein SB48_HM08orf00576 ENOG4105ERH Fumarylacetoacetate hydrolase SB48_HM08orf00580 ENOG4108KYE ABC-2 type transporter SB48_HM08orf00583 ENOG4105CJ1 ABC, transporter SB48_HM08orf00585 ENOG4105BZU Histidine kinase SB48_HM08orf00586 ENOG4105WH1 Two component transcriptional regulator luxr family SB48_HM08orf00589 ENOG4105D94 Major Facilitator Superfamily SB48_HM08orf00591 ENOG4105BZ1 (ABC) transporter SB48_HM08orf00595 ENOG4105C7N Xanthine uracil vitamin C permease SB48_HM08orf00598 ENOG4105CID antiterminator SB48_HM08orf00606 ENOG4105CK2 sodium dicarboxylate symporter SB48_HM08orf00616 ENOG4105CI1 PTS System SB48_HM08orf00620 ENOG4105CI1 PTS System SB48_HM08orf00624 ENOG4107ZXU DSBA oxidoreductase SB48_HM08orf00630 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) SB48_HM08orf00633 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit SB48_HM08orf00634 ENOG4105C83 adenylosuccinate lyase SB48_HM08orf00635 ENOG4105C8V SAICAR synthetase SB48_HM08orf00636 ENOG4105VR9 phosphoribosylformylglycinamidine synthase SB48_HM08orf00637 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I SB48_HM08orf00639 ENOG4107QIK phosphoribosylformylglycinamidine synthase SB48_HM08orf00641 ENOG4105CXB phosphoribosylaminoimidazole synthetase SB48_HM08orf00644 ENOG4108V3E phosphoribosylglycinamide formyltransferase SB48_HM08orf00645 ENOG4105DC1 bifunctional purine biosynthesis protein purh SB48_HM08orf00647 ENOG4105C12 Phosphoribosylglycinamide synthetase SB48_HM08orf00652 ENOG4108R5T secreted protein SB48_HM08orf00654 ENOG4105KGF protein, YerC YecD SB48_HM08orf00657 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) SB48_HM08orf00659 ENOG4105C4R Atp-dependent dna helicase SB48_HM08orf00660 ENOG4105C4R Atp-dependent dna helicase SB48_HM08orf00666 ENOG4107QP3 malate synthase g SB48_HM08orf00670 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) SB48_HM08orf00671 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) SB48_HM08orf00673 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) SB48_HM08orf00684 ENOG4105CBD Diacylglycerol kinase SB48_HM08orf00690 ENOG4105CK7 Sodium proline symporter SB48_HM08orf00712 ENOG4105F3R pts system mannose fructose sorbose family iid SB48_HM08orf00723 ENOG4105CHR reductase SB48_HM08orf00724 ENOG4107XZQ multidrug resistance protein SB48_HM08orf00739 ENOG4107VFR oxidoreductase SB48_HM08orf00761 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) SB48_HM08orf00768 ENOG4108HW3 (ABC) transporter SB48_HM08orf00769 ENOG4105E5Q amino acid AbC transporter SB48_HM08orf00770 ENOG4105CDA abc transporter atp-binding protein SB48_HM08orf00774 ENOG4108X3M OsmC Ohr family protein SB48_HM08orf00777 ENOG4105CZM Major Facilitator SB48_HM08orf00779 ENOG4105P4J Allophanate hydrolase, subunit 1 SB48_HM08orf00783 ENOG4105E7W lamb ycsf family protein SB48_HM08orf00788 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) SB48_HM08orf00798 ENOG4107RHR regulatoR SB48_HM08orf00805 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) SB48_HM08orf00806 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) SB48_HM08orf00811 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) SB48_HM08orf00822 ENOG4105GVF (ABC) transporter SB48_HM08orf00823 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) SB48_HM08orf00824 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component SB48_HM08orf00825 ENOG4105E2Y ABC, transporter SB48_HM08orf00826 ENOG4108UZX fmn reductase SB48_HM08orf00830 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase SB48_HM08orf00846 ENOG4105C26 Dehydrogenase SB48_HM08orf00847 ENOG4107QNK )-transporter SB48_HM08orf00849 ENOG4105EUF amidase EC 3.5.1.4 SB48_HM08orf00850 ENOG4105EBR Carboxylesterase SB48_HM08orf00859 ENOG4105K4H Nlp p60 protein SB48_HM08orf00863 ENOG4105BZ1 (ABC) transporter SB48_HM08orf00866 ENOG4105BZ1 (ABC) transporter SB48_HM08orf00869 ENOG4105EKQ RNA-directed DNA polymerase SB48_HM08orf00870 ENOG4105EHZ conserved protein UCP016719 SB48_HM08orf00875 ENOG4105D17 glycoside hydrolase, family 3 domain protein SB48_HM08orf00880 ENOG4105QYV Membrane SB48_HM08orf00891 ENOG4105VEQ Cold shock protein SB48_HM08orf00893 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) SB48_HM08orf00894 ENOG4105BZU Histidine kinase SB48_HM08orf00907 ENOG4105ETE Transcriptional regulator (LacI family SB48_HM08orf00908 ENOG4105DJV ribulose-phosphate 3-epimerase SB48_HM08orf00912 ENOG4108T5E Copper resistance protein SB48_HM08orf00913 ENOG4105KTB nuclear export factor GLE1 SB48_HM08orf00927 ENOG4105ETE Transcriptional regulator (LacI family SB48_HM08orf00928 ENOG4108RVA ribokinase SB48_HM08orf00929 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) SB48_HM08orf00931 ENOG4105C2J ABC transporter SB48_HM08orf00932 ENOG4105CNN ABC, transporter SB48_HM08orf00934 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator SB48_HM08orf00936 ENOG4107QQ0 gntp family SB48_HM08orf00937 ENOG4105BZW Glycerate kinase SB48_HM08orf00940 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR SB48_HM08orf00948 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase SB48_HM08orf00957 ENOG4107EXU Short-chain dehydrogenase reductase Sdr SB48_HM08orf00961 ENOG4105C6K Malic enzyme SB48_HM08orf00969 ENOG4105C2X Arabinose 5-phosphate isomerase SB48_HM08orf00970 ENOG4105CI1 PTS System SB48_HM08orf00975 ENOG4105C5Y PTS System SB48_HM08orf00977 ENOG4108V06 Glutathione peroxidase SB48_HM08orf00987 ENOG4105DEN Luciferase family SB48_HM08orf00988 ENOG4105CDA abc transporter atp-binding protein SB48_HM08orf00996 ENOG4108XSB acetyltransferase, (GNAT) family SB48_HM08orf00998 ENOG4108UZX fmn reductase SB48_HM08orf00999 ENOG4108KSA LysR family transcriptional regulator SB48_HM08orf01002 ENOG4105C6T cysteine synthase SB48_HM08orf01021 ENOG4105DZR Type I site-specific deoxyribonuclease SB48_HM08orf01024 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 SB48_HM08orf01026 ENOG4107SQC 5-methylcytosine-specific restriction enzyme subunit McrC SB48_HM08orf01030 ENOG4105WYW fructose-bisphosphate aldolase SB48_HM08orf01037 ENOG4108IUE nitrate reductase beta subunit SB48_HM08orf01050 ENOG4108IQI permease SB48_HM08orf01057 ENOG4108JUB Transcriptional regulator SB48_HM08orf01060 ENOG4105C8Y Acetylornithine aminotransferase SB48_HM08orf01062 ENOG4105CBT Fructose-1,6-bisphosphatase SB48_HM08orf01064 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) SB48_HM08orf01065 ENOG4108YZG isomerase SB48_HM08orf01067 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase SB48_HM08orf01071 ENOG4105DJB Major Facilitator Superfamily SB48_HM08orf01074 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) SB48_HM08orf01076 ENOG4105CMT Dihydroxyacetone kinase SB48_HM08orf01078 ENOG4105E98 transcriptional regulator DeoR family SB48_HM08orf01088 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) SB48_HM08orf01091 ENOG4105C1G acyl-Coa dehydrogenase SB48_HM08orf01097 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase SB48_HM08orf01098 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit SB48_HM08orf01099 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase SB48_HM08orf01101 ENOG4105E39 Enoyl-CoA hydratase SB48_HM08orf01102 ENOG4107QX3 carboxylase SB48_HM08orf01113 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) SB48_HM08orf01124 ENOG410635A Membrane SB48_HM08orf01129 ENOG4108DBC nitroreductase SB48_HM08orf01137 ENOG4105CMT Dihydroxyacetone kinase SB48_HM08orf01139 ENOG4108UTZ Dihydroxyacetone kinase SB48_HM08orf01140 ENOG4105VDH Dihydroxyacetone kinase SB48_HM08orf01147 ENOG4108JPW Aminotransferase SB48_HM08orf01159 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs SB48_HM08orf01162 ENOG4107QNK )-transporter SB48_HM08orf01165 ENOG4105C5Y PTS System SB48_HM08orf01168 ENOG410667J hydrolase SB48_HM08orf01175 ENOG4105DCT glycerol dehydrogenase SB48_HM08orf01176 ENOG4105E98 transcriptional regulator DeoR family SB48_HM08orf01181 ENOG4105DM4 PTS System SB48_HM08orf01183 ENOG4107SUZ Sodium/hydrogen exchanger family SB48_HM08orf01188 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) SB48_HM08orf01201 ENOG4105FB9 CRISPR-associated protein SB48_HM08orf01206 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) SB48_HM08orf01207 ENOG4105KCF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) SB48_HM08orf01209 ENOG41067QW Transcriptional regulator SB48_HM08orf01211 ENOG4105CVJ phosphoglycerate mutase SB48_HM08orf01215 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic SB48_HM08orf01216 ENOG4105PTM secreted protein SB48_HM08orf01231 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase SB48_HM08orf01233 ENOG4108V2W Carbonate dehydratase SB48_HM08orf01234 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) SB48_HM08orf01237 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) SB48_HM08orf01240 ENOG4105C28 cystathionine SB48_HM08orf01246 ENOG4105DZ6 Band 7 protein SB48_HM08orf01253 ENOG4108S4H thioesterase Superfamily protein SB48_HM08orf01257 ENOG4105K78 MarR family Transcriptional regulator SB48_HM08orf01262 ENOG4105E14 MotA TolQ exbB proton channel SB48_HM08orf01263 ENOG4105ER2 Ompa motb domain protein SB48_HM08orf01264 ENOG4107RKG DJ-1/PfpI family SB48_HM08orf01266 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) SB48_HM08orf01268 ENOG41068PA UPF0435 protein SB48_HM08orf01269 ENOG4107U9T Pfam:Ribonuclease_BN SB48_HM08orf01270 ENOG4108ISG Major Facilitator SB48_HM08orf01271 ENOG4105UPD Calcium Proton SB48_HM08orf01283 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) SB48_HM08orf01286 ENOG4105FS7 Transcriptional regulator SB48_HM08orf01288 ENOG4105BZ1 (ABC) transporter SB48_HM08orf01290 ENOG4105D1H recombination factor protein RarA SB48_HM08orf01298 ENOG4105C8Q Methyl-accepting chemotaxis SB48_HM08orf01301 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) SB48_HM08orf01303 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) SB48_HM08orf01312 ENOG4105CSH Transporter SB48_HM08orf01315 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) SB48_HM08orf01321 ENOG4105SXS Protein of unknown function (DUF456) SB48_HM08orf01323 ENOG4107R6U sodium dicarboxylate symporter SB48_HM08orf01326 ENOG4105VMP Transcriptional regulator SB48_HM08orf01328 ENOG4105NX3 Membrane SB48_HM08orf01330 ENOG4105EC8 Methyl-accepting chemotaxis SB48_HM08orf01347 ENOG4105ECB domain protein SB48_HM08orf01352 ENOG4107STQ Multicopper oxidase SB48_HM08orf01354 ENOG4105HDK L-asparaginase SB48_HM08orf01358 ENOG4108HRK Histidine kinase SB48_HM08orf01359 ENOG4105DY9 regulatoR SB48_HM08orf01362 ENOG4105FCD Major Facilitator SB48_HM08orf01366 ENOG4106I4J membrane SB48_HM08orf01368 ENOG4107E6A Cytochrome p-450 SB48_HM08orf01378 ENOG4105C01 Dihydroxy-acid dehydratase SB48_HM08orf01382 ENOG4105C7K acetolactate synthase SB48_HM08orf01383 ENOG4108ZP8 Acetolactate synthase small subunit SB48_HM08orf01386 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase SB48_HM08orf01388 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) SB48_HM08orf01389 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) SB48_HM08orf01390 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) SB48_HM08orf01393 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) SB48_HM08orf01394 ENOG4105C7B Threonine dehydratase SB48_HM08orf01401 ENOG4108JQ1 Dehydrogenase SB48_HM08orf01403 ENOG4105C5R Aminotransferase SB48_HM08orf01404 ENOG4105C5I Dehydrogenase SB48_HM08orf01406 ENOG4105C8Q Methyl-accepting chemotaxis SB48_HM08orf01415 ENOG4105C26 Dehydrogenase SB48_HM08orf01415 ENOG4105C26 Dehydrogenase SB48_HM08orf01421 ENOG4105BZU Histidine kinase SB48_HM08orf01422 ENOG4108Q9V regulatoR SB48_HM08orf01431 ENOG4105CJ1 ABC, transporter SB48_HM08orf01435 ENOG410624X efflux transporter, rnd family, mfp subunit SB48_HM08orf01437 ENOG4107RBB ABC transporter, permease SB48_HM08orf01443 ENOG4105CRQ synthase (Component I) SB48_HM08orf01444 ENOG4105DDQ anthranilate synthase SB48_HM08orf01445 ENOG4108I0Q anthranilate phosphoribosyltransferase SB48_HM08orf01446 ENOG4105DK0 Indole-3-glycerol phosphate synthase SB48_HM08orf01447 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) SB48_HM08orf01449 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) SB48_HM08orf01454 ENOG410902V Modulates RecA activity (By similarity) SB48_HM08orf01466 ENOG4105CEN a g-specific adenine glycosylase SB48_HM08orf01468 ENOG41067AE Membrane-bound metal-dependent hydrolase SB48_HM08orf01470 ENOG4105XHU Acid-soluble spore protein K SB48_HM08orf01471 ENOG4105CJ1 ABC, transporter SB48_HM08orf01477 ENOG4105BZ8 glutamate synthase SB48_HM08orf01482 ENOG4105CBC glutamate synthase SB48_HM08orf01483 ENOG4105C5Q Transcriptional regulator SB48_HM08orf01484 ENOG4105CAN Short-chain dehydrogenase reductase Sdr SB48_HM08orf01488 ENOG4105EVI UPF0374 protein SB48_HM08orf01489 ENOG4105BZ1 (ABC) transporter SB48_HM08orf01492 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate SB48_HM08orf01493 ENOG4105C5Y PTS System SB48_HM08orf01496 ENOG4107NBY Membrane SB48_HM08orf01502 ENOG4107RCC Major Facilitator Superfamily SB48_HM08orf01505 ENOG4105E2Y ABC, transporter SB48_HM08orf01506 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component SB48_HM08orf01507 ENOG4105GVF (ABC) transporter SB48_HM08orf01510 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase SB48_HM08orf01516 ENOG4105G5W regulator Fur family SB48_HM08orf01521 ENOG4107RSM transcriptional regulator SB48_HM08orf01524 ENOG4107FQX Alpha-acetolactate decarboxylase SB48_HM08orf01525 ENOG4105TUA UPF0295 protein SB48_HM08orf01533 ENOG4105H67 Protein of unknown function (DUF421) SB48_HM08orf01536 ENOG4105DEN Luciferase family SB48_HM08orf01550 ENOG4105D2S major facilitator superfamily SB48_HM08orf01562 ENOG41067TZ transcriptional regulator, MarR family SB48_HM08orf01567 ENOG4108IUW ABC transporter SB48_HM08orf01568 ENOG4107VFR oxidoreductase SB48_HM08orf01569 ENOG4105DUX Transporter SB48_HM08orf01570 ENOG4105FDP GntR family transcriptional regulator SB48_HM08orf01579 ENOG41062D9 Histidine kinase SB48_HM08orf01580 ENOG4105CK6 Two component transcriptional regulator (Winged helix family SB48_HM08orf01590 ENOG4105CJ1 ABC, transporter SB48_HM08orf01597 ENOG4107V0Z fmn reductase SB48_HM08orf01599 ENOG4105F1A Pyruvate formate-lyase SB48_HM08orf01600 ENOG4105C6N Formate acetyltransferase SB48_HM08orf01610 ENOG4106NWU SB48_HM08orf01612 ENOG4108QTI )-transporter SB48_HM08orf01614 ENOG4105CDA abc transporter atp-binding protein SB48_HM08orf01615 ENOG4105DRP amino acid AbC transporter SB48_HM08orf01618 ENOG4107WD4 Releases the N-terminal proline from various substrates (By similarity) SB48_HM08orf01626 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein SB48_HM08orf01629 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) SB48_HM08orf01632 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) SB48_HM08orf01638 ENOG4105CYN Serine protein kinase SB48_HM08orf01640 ENOG4106AKX UPF0229 protein SB48_HM08orf01645 ENOG4105CJ3 phosphate transporter SB48_HM08orf01647 ENOG4107GRR phosphate transport regulator SB48_HM08orf01655 ENOG4108TGC Acyltransferase SB48_HM08orf01657 ENOG4105ED1 spovr family SB48_HM08orf01666 ENOG4105D7N magnesium and cobalt transport protein CorA SB48_HM08orf01668 ENOG4108Z86 Glutamine amidotransferase SB48_HM08orf01670 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component SB48_HM08orf01671 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component SB48_HM08orf01673 ENOG4105C3U ABC transporter SB48_HM08orf01678 ENOG4107SN7 NLP P60 protein SB48_HM08orf01681 ENOG4108JQ7 (ABC) transporter SB48_HM08orf01685 ENOG4105BZ4 penicillin-binding protein SB48_HM08orf01692 ENOG4106YBV Methyl-accepting chemotaxis SB48_HM08orf01698 ENOG4108IEG Formate dehydrogenase Alpha subunit SB48_HM08orf01706 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) SB48_HM08orf01714 ENOG4105BZA Phosphoglycerate kinase SB48_HM08orf01716 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) SB48_HM08orf01719 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) SB48_HM08orf01724 ENOG4105XZU Preprotein translocase, subunit SecG SB48_HM08orf01728 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) SB48_HM08orf01732 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) SB48_HM08orf01735 ENOG4105CKK Glycosyl transferase, family 2 SB48_HM08orf01751 ENOG4107HP6 Transcriptional regulator SB48_HM08orf01754 ENOG4108UHU Aldolase SB48_HM08orf01757 ENOG4107QZW Altronate oxidoreductase SB48_HM08orf01758 ENOG4105CTX dehydratase SB48_HM08orf01759 ENOG4105D2H Uronic isomerase SB48_HM08orf01761 ENOG4105CT4 transporter SB48_HM08orf01763 ENOG4105CHR reductase SB48_HM08orf01764 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) SB48_HM08orf01766 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) SB48_HM08orf01784 ENOG4105EMN RNA polymerase sigma factor SB48_HM08orf01792 ENOG4108QBV Monogalactosyldiacylglycerol synthase SB48_HM08orf01796 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase SB48_HM08orf01798 ENOG4105CH6 catalase SB48_HM08orf01800 ENOG4105BZU Histidine kinase SB48_HM08orf01810 ENOG4105SZ6 Thioredoxin SB48_HM08orf01822 ENOG4105CHU acetyl-coa acetyltransferase SB48_HM08orf01826 ENOG4105C1G acyl-Coa dehydrogenase SB48_HM08orf01828 ENOG41080E8 Transcriptional regulator, Spx MgsR family SB48_HM08orf01829 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) SB48_HM08orf01838 ENOG4105C3K feS assembly ATPase SufC SB48_HM08orf01839 ENOG4105JRK feS assembly protein SufD SB48_HM08orf01842 ENOG4108UNV SUF system FeS assembly protein, NifU family SB48_HM08orf01844 ENOG4105DIW FeS assembly protein SUFB SB48_HM08orf01847 ENOG4107R8B 5'-nucleotidase SB48_HM08orf01848 ENOG4105KZD Domain of unknown function (DUF1805) SB48_HM08orf01850 ENOG4108YTE sporulation protein YunB SB48_HM08orf01852 ENOG4105FAA peptidase M23 SB48_HM08orf01855 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) SB48_HM08orf01857 ENOG4105MMD transcriptional regulator SB48_HM08orf01860 ENOG4105D4U had-superfamily hydrolase, subfamily iia SB48_HM08orf01862 ENOG4108W5N phosphatidylglycerophosphatase a SB48_HM08orf01867 ENOG41083MR nifu domain-containing protein SB48_HM08orf01872 ENOG4108YX9 iron--sulfur cluster insertion protein erpA SB48_HM08orf01884 ENOG4105CAY ferredoxin--nadp reductase SB48_HM08orf01887 ENOG4105CEP NADH dehydrogenase SB48_HM08orf01893 ENOG41069ER domain protein SB48_HM08orf01899 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) SB48_HM08orf01901 ENOG4105E1K spore germination protein SB48_HM08orf01912 ENOG4105KA0 thioesterase Superfamily protein SB48_HM08orf01923 ENOG4105Y38 Kinase-associated protein B SB48_HM08orf01926 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) SB48_HM08orf01937 ENOG4105CV8 reductase SB48_HM08orf01952 ENOG4105WG9 Conserved Protein SB48_HM08orf01955 ENOG4107PBV potassium channel SB48_HM08orf01963 ENOG4105C26 Dehydrogenase SB48_HM08orf01975 ENOG4105CHR reductase SB48_HM08orf01985 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer SB48_HM08orf01986 ENOG4105CMD Transcriptional regulator, GntR family SB48_HM08orf01992 ENOG4108HWW ABC transporter SB48_HM08orf01994 ENOG4105DFW ABC transporter SB48_HM08orf01995 ENOG4105CMD Transcriptional regulator, GntR family SB48_HM08orf01997 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) SB48_HM08orf01998 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase SB48_HM08orf02003 ENOG4107QNK )-transporter SB48_HM08orf02008 ENOG4105C5Y PTS System SB48_HM08orf02011 ENOG4107Y9E nuclease SB48_HM08orf02013 ENOG4105XTG Pfam:DUF156 SB48_HM08orf02014 ENOG41085GJ domain protein SB48_HM08orf02018 ENOG4107R4J Chloride channel SB48_HM08orf02030 ENOG4107VMI polysaccharide deacetylase SB48_HM08orf02035 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding SB48_HM08orf02042 ENOG4105E1V na solute symporter SB48_HM08orf02043 ENOG4106CAD Protein of unknown function (DUF3311) SB48_HM08orf02052 ENOG410681U heavy metal transport detoxification protein SB48_HM08orf02055 ENOG4105C59 p-type ATPase SB48_HM08orf02066 ENOG4105KT7 mgtC SapB transporter SB48_HM08orf02072 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase SB48_HM08orf02074 ENOG4105E4F Isochorismate synthase SB48_HM08orf02076 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) SB48_HM08orf02078 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) SB48_HM08orf02079 ENOG4108IPT Naphthoate synthase SB48_HM08orf02083 ENOG4105CEY Amp-dependent synthetase and ligase SB48_HM08orf02084 ENOG4105DTQ mandelate racemase muconate lactonizing SB48_HM08orf02088 ENOG4105DSE periplasmic solute binding protein SB48_HM08orf02093 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) SB48_HM08orf02095 ENOG4108RMU ferritin dps family protein SB48_HM08orf02101 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component SB48_HM08orf02103 ENOG4105D2X ABC transporter substrate-binding protein SB48_HM08orf02106 ENOG4105CMG Carbohydrate kinase SB48_HM08orf02110 ENOG4108WS4 fmn reductase SB48_HM08orf02118 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP SB48_HM08orf02122 ENOG4105CAQ asparagine synthetase SB48_HM08orf02128 ENOG4108Z0R Transferase SB48_HM08orf02130 ENOG4105E8V Alpha Beta Hydrolase Fold protein SB48_HM08orf02138 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) SB48_HM08orf02144 ENOG410605W Major Facilitator SB48_HM08orf02146 ENOG4105C8T Leucyl-tRNA synthetase SB48_HM08orf02155 ENOG4105YW5 deoR family transcriptional regulator SB48_HM08orf02159 ENOG4107QSE Dipeptidase SB48_HM08orf02168 ENOG4108V15 phosphotransferase enzyme family SB48_HM08orf02170 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) SB48_HM08orf02176 ENOG4105C8F Beta-lactamase domain protein SB48_HM08orf02187 ENOG4105BZU Histidine kinase SB48_HM08orf02189 ENOG4105BZU Histidine kinase SB48_HM08orf02190 ENOG4108MJI response regulator SB48_HM08orf02198 ENOG4108NKM UPF0354 protein SB48_HM08orf02200 ENOG4108VDD TRNA binding domain protein SB48_HM08orf02213 ENOG4105DFU Cell wall formation (By similarity) SB48_HM08orf02222 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase SB48_HM08orf02225 ENOG4105ETE Transcriptional regulator (LacI family SB48_HM08orf02228 ENOG4105DGU Histone deacetylase SB48_HM08orf02230 ENOG4105W87 Cbs domain SB48_HM08orf02231 ENOG4105F1V Acetoin utilization protein SB48_HM08orf02235 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein SB48_HM08orf02236 ENOG4105E0C molybdate abc transporter SB48_HM08orf02239 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) SB48_HM08orf02240 ENOG4105EPU Molybdenum cofactor synthesis domain protein SB48_HM08orf02244 ENOG4105CVM Molybdenum cofactor synthesis domain protein SB48_HM08orf02246 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein SB48_HM08orf02248 ENOG4108ZAF Molybdopterin SB48_HM08orf02250 ENOG41067WU Molybdopterin converting factor (Subunit 1) SB48_HM08orf02251 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) SB48_HM08orf02252 ENOG4105D06 uba thif-type nad fad binding protein SB48_HM08orf02257 ENOG4108JB9 formate dehydrogenase SB48_HM08orf02259 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) SB48_HM08orf02266 ENOG4108JUB Transcriptional regulator SB48_HM08orf02269 ENOG4105C26 Dehydrogenase SB48_HM08orf02272 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) SB48_HM08orf02276 ENOG4105BZU Histidine kinase SB48_HM08orf02279 ENOG4105U5Y Transcriptional regulator SB48_HM08orf02282 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) SB48_HM08orf02284 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) SB48_HM08orf02285 ENOG4105YWU small acid-soluble spore protein SB48_HM08orf02286 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) SB48_HM08orf02288 ENOG4105D07 Signal peptide peptidase, SppA SB48_HM08orf02289 ENOG4105VK3 rdd domain containing protein SB48_HM08orf02293 ENOG4105KBJ sporulation protein ytfj SB48_HM08orf02296 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) SB48_HM08orf02302 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) SB48_HM08orf02307 ENOG4107YZX Universal stress protein SB48_HM08orf02313 ENOG4105DC7 peptidase M24 SB48_HM08orf02314 ENOG4105E8R UPF0173 metal-dependent hydrolase SB48_HM08orf02321 ENOG4105SFS phosphoesterase RecJ domain protein SB48_HM08orf02324 ENOG4105VV2 SB48_HM08orf02325 ENOG4105C0B DNA polymerase III (alpha subunit) SB48_HM08orf02326 ENOG4105C6K Malic enzyme SB48_HM08orf02328 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) SB48_HM08orf02329 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) SB48_HM08orf02331 ENOG4105CTQ phosphohexokinase SB48_HM08orf02334 ENOG4108REF Sporulation integral membrane protein ytvi SB48_HM08orf02335 ENOG4108VMM UPF0756 membrane protein SB48_HM08orf02337 ENOG4105BZN citrate synthase SB48_HM08orf02338 ENOG4108HMX isocitrate dehydrogenase (NADP) SB48_HM08orf02340 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) SB48_HM08orf02343 ENOG4105C2M dna polymerase I SB48_HM08orf02344 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) SB48_HM08orf02349 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) SB48_HM08orf02350 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase SB48_HM08orf02351 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) SB48_HM08orf02356 ENOG4108TDW sporulation protein YtxC SB48_HM08orf02360 ENOG4105C22 threonyL-tRNA synthetase SB48_HM08orf02366 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) SB48_HM08orf02367 ENOG4105VJV 50s ribosomal protein L35 SB48_HM08orf02369 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) SB48_HM08orf02372 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) SB48_HM08orf02381 ENOG4107SDU Methyl-accepting chemotaxis SB48_HM08orf02383 ENOG4108YYH Nadph-dependent fmn reductase SB48_HM08orf02387 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) SB48_HM08orf02394 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) SB48_HM08orf02402 ENOG41067MF small acid-soluble spore protein SB48_HM08orf02403 ENOG4108RWN rrna methyltransferase SB48_HM08orf02407 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) SB48_HM08orf02409 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) SB48_HM08orf02411 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) SB48_HM08orf02419 ENOG4105DCG PHP domain protein SB48_HM08orf02421 ENOG4105C98 muts2 protein SB48_HM08orf02423 ENOG4105CEY Amp-dependent synthetase and ligase SB48_HM08orf02427 ENOG4107Z3H Transcriptional regulator, TetR family SB48_HM08orf02428 ENOG41060WC Enoyl-CoA hydratase SB48_HM08orf02430 ENOG4105BZJ Electron transfer flavoprotein SB48_HM08orf02431 ENOG4105C10 Electron transfer flavoprotein SB48_HM08orf02434 ENOG4105K63 Thioredoxin SB48_HM08orf02435 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) SB48_HM08orf02445 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit SB48_HM08orf02448 ENOG4105E33 succinate dehydrogenase SB48_HM08orf02450 ENOG4105PFC Transcriptional regulator SB48_HM08orf02463 ENOG41067TZ transcriptional regulator, MarR family SB48_HM08orf02468 ENOG4105E2A Dehydrogenase SB48_HM08orf02472 ENOG4108XJQ germination protein SB48_HM08orf02474 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) SB48_HM08orf02476 ENOG4105M59 Phosphodiesterase, mj0936 family SB48_HM08orf02488 ENOG4105EKQ RNA-directed DNA polymerase SB48_HM08orf02492 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation SB48_HM08orf02494 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) SB48_HM08orf02497 ENOG4108IUQ atp-dependent protease SB48_HM08orf02498 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) SB48_HM08orf02500 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) SB48_HM08orf02505 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) SB48_HM08orf02508 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) SB48_HM08orf02512 ENOG4105D52 delta-aminolevulinic acid dehydratase SB48_HM08orf02514 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase SB48_HM08orf02518 ENOG41068KH stage VI sporulation protein D SB48_HM08orf02518 ENOG41068KH stage VI sporulation protein D SB48_HM08orf02519 ENOG4106AR7 Spore coat protein SB48_HM08orf02527 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) SB48_HM08orf02529 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase SB48_HM08orf02542 ENOG4107QHF type ii secretion system protein e SB48_HM08orf02544 ENOG4105CZX twitching motility protein SB48_HM08orf02545 ENOG4105D7Q type ii secretion system SB48_HM08orf02553 ENOG4106A3R peptidase SB48_HM08orf02560 ENOG4105W5Q DNA repair protein (RadC SB48_HM08orf02561 ENOG4105DFF Rod shape-determining protein mreb SB48_HM08orf02562 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) SB48_HM08orf02568 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) SB48_HM08orf02569 ENOG4107QMS site-determining protein SB48_HM08orf02575 ENOG4105C03 ribonuclease SB48_HM08orf02578 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) SB48_HM08orf02580 ENOG4105X36 (ribosomal) protein SB48_HM08orf02581 ENOG4105K46 50S ribosomal protein l27 SB48_HM08orf02583 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control SB48_HM08orf02585 ENOG41090I5 UPF0735 ACT domain-containing protein SB48_HM08orf02586 ENOG4105CQC Prephenate dehydratase SB48_HM08orf02589 ENOG4106678 morphogenetic protein associated with SpoVID SB48_HM08orf02594 ENOG4105CDY transcriptional regulatory protein SB48_HM08orf02601 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) SB48_HM08orf02603 ENOG41061AI Protein of unknown function (DUF2905) SB48_HM08orf02604 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) SB48_HM08orf02606 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) SB48_HM08orf02608 ENOG4105VIE preprotein translocase, subunit YajC SB48_HM08orf02611 ENOG4108QG2 Membrane SB48_HM08orf02613 ENOG4105CKP Polysaccharide Biosynthesis Protein SB48_HM08orf02619 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) SB48_HM08orf02622 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) SB48_HM08orf02623 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) SB48_HM08orf02627 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) SB48_HM08orf02628 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) SB48_HM08orf02629 ENOG410834F Transcriptional regulator SB48_HM08orf02630 ENOG4105CW7 secretion protein, HlyD family SB48_HM08orf02632 ENOG4105C0R drug resistance transporter emrb qaca subfamily SB48_HM08orf02633 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase SB48_HM08orf02640 ENOG4105CUT histidyl-tRNA synthetase SB48_HM08orf02642 ENOG4105C9M aspartyl-trna synthetase SB48_HM08orf02647 ENOG4105CUZ uba thif-type nad fad binding protein SB48_HM08orf02651 ENOG4105D1H recombination factor protein RarA SB48_HM08orf02654 ENOG41061TZ Short-chain dehydrogenase reductase Sdr SB48_HM08orf02660 ENOG4105C3J Cysteine desulfurase SB48_HM08orf02661 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) SB48_HM08orf02666 ENOG4105C7H Helicase, RecD TraA family SB48_HM08orf02677 ENOG41060CR SB48_HM08orf02681 ENOG4105C02 permease SB48_HM08orf02684 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) SB48_HM08orf02685 ENOG4105VBH UPF0297 protein SB48_HM08orf02686 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) SB48_HM08orf02687 ENOG4105VPH UPF0473 protein SB48_HM08orf02689 ENOG4105HHA aminodeoxychorismate lyase SB48_HM08orf02690 ENOG4108VQJ O-methyltransferase SB48_HM08orf02691 ENOG4105DBI uridine monophosphokinase SB48_HM08orf02693 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) SB48_HM08orf02703 ENOG4105D3R alkyl hydroperoxide reductase SB48_HM08orf02704 ENOG4108JU3 Alkyl hydroperoxide reductase SB48_HM08orf02707 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) SB48_HM08orf02709 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase SB48_HM08orf02713 ENOG4105PGM cation diffusion facilitator family transporter SB48_HM08orf02728 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen SB48_HM08orf02731 ENOG4107Y70 Heat shock protein SB48_HM08orf02732 ENOG4107STQ Multicopper oxidase SB48_HM08orf02736 ENOG4105CQB FAD linked oxidase domain protein SB48_HM08orf02737 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) SB48_HM08orf02742 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase SB48_HM08orf02743 ENOG4105CQW ribosome biogenesis GTPase YqeH SB48_HM08orf02745 ENOG410812S Rna-binding protein SB48_HM08orf02746 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) SB48_HM08orf02748 ENOG4108WF2 Metal Dependent Phosphohydrolase SB48_HM08orf02750 ENOG4105DXX methyltransferase SB48_HM08orf02755 ENOG4105KQC Competence protein SB48_HM08orf02757 ENOG4108UK2 deaminase SB48_HM08orf02758 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 SB48_HM08orf02762 ENOG4105TQK DNA polymerase iii, delta' subunit SB48_HM08orf02764 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) SB48_HM08orf02767 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) SB48_HM08orf02769 ENOG4108ZRV stage ii sporulation protein p SB48_HM08orf02770 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) SB48_HM08orf02772 ENOG4105CSA Coproporphyrinogen iii oxidase SB48_HM08orf02774 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ SB48_HM08orf02775 ENOG4105CFG Acts as a chaperone (By similarity) SB48_HM08orf02777 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) SB48_HM08orf02779 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) SB48_HM08orf02780 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) SB48_HM08orf02781 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) SB48_HM08orf02786 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) SB48_HM08orf02787 ENOG4105VCC 30S ribosomal protein S21 SB48_HM08orf02788 ENOG4105KTH gatB Yqey SB48_HM08orf02791 ENOG41068P3 sporulation protein YqfC SB48_HM08orf02793 ENOG4105C9A Phoh family SB48_HM08orf02797 ENOG4105CTJ Metal Dependent Phosphohydrolase SB48_HM08orf02798 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) SB48_HM08orf02799 ENOG4107YR5 Diacylglycerol kinase SB48_HM08orf02802 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) SB48_HM08orf02805 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) SB48_HM08orf02808 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) SB48_HM08orf02813 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) SB48_HM08orf02814 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) SB48_HM08orf02821 ENOG4105EGD dinuclear metal center protein, YbgI family SB48_HM08orf02825 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) SB48_HM08orf02834 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) SB48_HM08orf02841 ENOG4105FDK ABC transporter SB48_HM08orf02842 ENOG4105FAV ABC, transporter SB48_HM08orf02844 ENOG4105N80 Ferric uptake regulator, Fur family SB48_HM08orf02847 ENOG4108U5J '-nucleotidase SB48_HM08orf02848 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) SB48_HM08orf02850 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) SB48_HM08orf02854 ENOG4107RF6 penicillin-binding protein SB48_HM08orf02856 ENOG4105WDJ 50S ribosomal protein L33 SB48_HM08orf02861 ENOG4107ZXI Rhomboid family SB48_HM08orf02865 ENOG4105DKQ ROK family SB48_HM08orf02868 ENOG4105C5X domain protein SB48_HM08orf02876 ENOG4106855 Competence protein SB48_HM08orf02883 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) SB48_HM08orf02887 ENOG4105C0D helicase SB48_HM08orf02891 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) SB48_HM08orf02893 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor SB48_HM08orf02894 ENOG4105WZW rhodanese family SB48_HM08orf02896 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) SB48_HM08orf02899 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) SB48_HM08orf02903 ENOG4105CAY ferredoxin--nadp reductase SB48_HM08orf02905 ENOG4105CGU Enoyl-CoA hydratase SB48_HM08orf02908 ENOG4105C26 Dehydrogenase SB48_HM08orf02909 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase SB48_HM08orf02910 ENOG4105CHU acetyl-coa acetyltransferase SB48_HM08orf02911 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein SB48_HM08orf02913 ENOG4105EA8 2-Nitropropane dioxygenase SB48_HM08orf02917 ENOG4105CBJ Metal-dependent enzyme SB48_HM08orf02924 ENOG4105DC7 peptidase M24 SB48_HM08orf02925 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) SB48_HM08orf02927 ENOG4105CD2 stage iii sporulation protein aa SB48_HM08orf02928 ENOG4105KR5 Stage iii sporulation protein SB48_HM08orf02929 ENOG4108CQH stage III sporulation protein AC SB48_HM08orf02931 ENOG4105KQ4 Stage iii sporulation protein ad SB48_HM08orf02934 ENOG410644B Stage III sporulation protein af SB48_HM08orf02942 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase SB48_HM08orf02943 ENOG4108ZSR alkaline shock protein SB48_HM08orf02944 ENOG4105M7K Involved in the transcription termination process (By similarity) SB48_HM08orf02948 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) SB48_HM08orf02952 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) SB48_HM08orf02954 ENOG4105DX0 Hemolysin A SB48_HM08orf02956 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) SB48_HM08orf02957 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) SB48_HM08orf02958 ENOG4105S1Z Stage IV sporulation protein B SB48_HM08orf02960 ENOG4107QQR Sporulation SB48_HM08orf02962 ENOG4108QXE glycerophosphoryl diester phosphodiesterase SB48_HM08orf02969 ENOG4108JUB Transcriptional regulator SB48_HM08orf02971 ENOG4108JUB Transcriptional regulator SB48_HM08orf02973 ENOG4107RDP Dehydrogenase SB48_HM08orf02977 ENOG4105CPP Dehydrogenase, E1 component SB48_HM08orf02979 ENOG4105C7S Dehydrogenase SB48_HM08orf02983 ENOG4105DE4 1-phosphofructokinase SB48_HM08orf02986 ENOG4108Y6J UPF0403 protein SB48_HM08orf02989 ENOG4108VZI ErfK ybiS ycfS ynhG family protein SB48_HM08orf02993 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) SB48_HM08orf02996 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) SB48_HM08orf02999 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase SB48_HM08orf03002 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) SB48_HM08orf03004 ENOG4105II7 pyrroline-5-carboxylate reductase SB48_HM08orf03009 ENOG4108IXY short-chain dehydrogenase reductase SB48_HM08orf03011 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) SB48_HM08orf03017 ENOG4105VRS hydrolase family 18 SB48_HM08orf03023 ENOG4105CDW Resistance protein SB48_HM08orf03031 ENOG4105CPC Aldo Keto reductase SB48_HM08orf03036 ENOG4105MZ9 stage II sporulation protein m SB48_HM08orf03039 ENOG4105I3K Ferric uptake regulator, Fur family SB48_HM08orf03042 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) SB48_HM08orf03045 ENOG4105DZ1 carboxypeptidase SB48_HM08orf03047 ENOG41082AN stage II sporulation protein SB48_HM08orf03050 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) SB48_HM08orf03056 ENOG4105G6R Stage v sporulation protein ae SB48_HM08orf03065 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) SB48_HM08orf03068 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) SB48_HM08orf03070 ENOG4105DZ1 carboxypeptidase SB48_HM08orf03071 ENOG4108JIC nucleoside recognition domain protein SB48_HM08orf03075 ENOG4105FE9 pseudouridine synthase SB48_HM08orf03077 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen SB48_HM08orf03079 ENOG4107TWT Cytochrome c biogenesis protein SB48_HM08orf03081 ENOG4105CRE cytochrome C SB48_HM08orf03084 ENOG4105CK6 Two component transcriptional regulator (Winged helix family SB48_HM08orf03086 ENOG4105BZU Histidine kinase SB48_HM08orf03089 ENOG4105E4C Lytic transglycosylase catalytic SB48_HM08orf03091 ENOG4108SAX Membrane SB48_HM08orf03100 ENOG4105C9U ATP-dependent DNA helicase RecQ SB48_HM08orf03102 ENOG4105I7S Abortive infection protein SB48_HM08orf03105 ENOG4105WEF catalase SB48_HM08orf03109 ENOG4107RGJ metallophosphoesterase SB48_HM08orf03116 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase SB48_HM08orf03121 ENOG4105F0V Cell wall hydrolase SB48_HM08orf03123 ENOG4105MSI germination protein ypeb SB48_HM08orf03128 ENOG4105CAT Cytidine monophosphate kinase SB48_HM08orf03131 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) SB48_HM08orf03137 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) SB48_HM08orf03144 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) SB48_HM08orf03146 ENOG4105K70 DNA-binding protein SB48_HM08orf03150 ENOG4105XXQ heptaprenyl diphosphate synthase component I SB48_HM08orf03152 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) SB48_HM08orf03154 ENOG4105EAH synthase SB48_HM08orf03156 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) SB48_HM08orf03157 ENOG4105BZU Histidine kinase SB48_HM08orf03158 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase SB48_HM08orf03160 ENOG4105D49 3-dehydroquinate synthase SB48_HM08orf03161 ENOG4105KHN chorismate mutase SB48_HM08orf03162 ENOG4105CIH Imidazole acetol-phosphate transaminase SB48_HM08orf03166 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase SB48_HM08orf03171 ENOG41068YB TPR repeat-containing protein SB48_HM08orf03173 ENOG4108SXZ UPF0302 protein SB48_HM08orf03175 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) SB48_HM08orf03176 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) SB48_HM08orf03178 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit SB48_HM08orf03186 ENOG4108JYZ YitT family SB48_HM08orf03188 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase SB48_HM08orf03190 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) SB48_HM08orf03193 ENOG4105FJR Lmbe family SB48_HM08orf03194 ENOG4105CPK Glycosyl transferase (Group 1 SB48_HM08orf03197 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) SB48_HM08orf03198 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) SB48_HM08orf03199 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) SB48_HM08orf03202 ENOG4105DVT helicase SB48_HM08orf03208 ENOG4105C5S asparaginyl-tRNA synthetase SB48_HM08orf03209 ENOG4105EKQ RNA-directed DNA polymerase SB48_HM08orf03211 ENOG4105CSM endonuclease III SB48_HM08orf03215 ENOG4105BZ4 penicillin-binding protein SB48_HM08orf03217 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) SB48_HM08orf03226 ENOG4105VN1 Heat shock protein SB48_HM08orf03228 ENOG4108I5C dEAD DEAH box helicase SB48_HM08orf03231 ENOG4107X2U Inherit from COG: Exonuclease-like protein SB48_HM08orf03237 ENOG4106F55 Protein of unknown function (DUF1273) SB48_HM08orf03238 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) SB48_HM08orf03243 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) SB48_HM08orf03244 ENOG4105CTD carboxy-peptidase SB48_HM08orf03250 ENOG4105C2W permease SB48_HM08orf03257 ENOG410890F Dynamin family SB48_HM08orf03259 ENOG4105KV4 Transcriptional regulator SB48_HM08orf03262 ENOG4105C5F glutamine synthetase SB48_HM08orf03264 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) SB48_HM08orf03267 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) SB48_HM08orf03269 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) SB48_HM08orf03284 ENOG4108UUM single-stranded DNA-binding protein SB48_HM08orf03293 ENOG410682Q Phage transcriptional regulator, ArpU SB48_HM08orf03304 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) SB48_HM08orf03316 ENOG4108FKH Transglycosylase SLT domain SB48_HM08orf03331 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) SB48_HM08orf03333 ENOG4108SVB resolvase SB48_HM08orf03334 ENOG4105VPS UPF0291 protein SB48_HM08orf03339 ENOG4105VXM UPF0154 protein SB48_HM08orf03342 ENOG4107QIV Cytochrome c biogenesis protein SB48_HM08orf03343 ENOG4107YTP response regulator receiver protein SB48_HM08orf03352 ENOG4105F6E Acyl-transferase SB48_HM08orf03355 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family SB48_HM08orf03356 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A SB48_HM08orf03366 ENOG4105WEF catalase SB48_HM08orf03369 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase SB48_HM08orf03370 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) SB48_HM08orf03371 ENOG4105CAS nag kinase SB48_HM08orf03373 ENOG4105C8Y Acetylornithine aminotransferase SB48_HM08orf03374 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain SB48_HM08orf03375 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain SB48_HM08orf03377 ENOG4105DBV ornithine carbamoyltransferase SB48_HM08orf03378 ENOG4105CDH Citrulline--aspartate ligase SB48_HM08orf03379 ENOG4105CH7 arginosuccinase SB48_HM08orf03381 ENOG4105CHM Aminotransferase SB48_HM08orf03389 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) SB48_HM08orf03392 ENOG4105V75 Transcriptional regulator SB48_HM08orf03405 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) SB48_HM08orf03408 ENOG4107S21 permease SB48_HM08orf03412 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) SB48_HM08orf03413 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) SB48_HM08orf03416 ENOG4105CQB FAD linked oxidase domain protein SB48_HM08orf03419 ENOG4105CHR reductase SB48_HM08orf03421 ENOG410900P UPF0336 protein SB48_HM08orf03424 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) SB48_HM08orf03435 ENOG4105CJ1 ABC, transporter SB48_HM08orf03436 ENOG4108TU7 Inherit from COG: (ABC) transporter SB48_HM08orf03439 ENOG4105HUF DNA protection during starvation protein SB48_HM08orf03442 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) SB48_HM08orf03445 ENOG4105P8F nudix hydrolase SB48_HM08orf03448 ENOG4107TCE N-acetyltransferase SB48_HM08orf03459 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) SB48_HM08orf03460 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) SB48_HM08orf03463 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) SB48_HM08orf03468 ENOG4105CGK Exodeoxyribonuclease III SB48_HM08orf03470 ENOG4105EU0 Major facilitator Superfamily SB48_HM08orf03471 ENOG41061TZ Short-chain dehydrogenase reductase Sdr SB48_HM08orf03474 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) SB48_HM08orf03481 ENOG4108SJC Membrane SB48_HM08orf03482 ENOG4108X4Q Hydrolase SB48_HM08orf03485 ENOG4105E1J oxidoreductase SB48_HM08orf03488 ENOG4105G9B Transcriptional regulator SB48_HM08orf03491 ENOG4105C5R Aminotransferase SB48_HM08orf03492 ENOG4105EKQ RNA-directed DNA polymerase SB48_HM08orf03497 ENOG4105CEY Amp-dependent synthetase and ligase SB48_HM08orf03498 ENOG4105CHU acetyl-coa acetyltransferase SB48_HM08orf03501 ENOG41069DP small acid-soluble spore protein SB48_HM08orf03502 ENOG4108UVJ appr-1-p processing domain protein SB48_HM08orf03507 ENOG4108CCU Ribonucleotide-diphosphate reductase subunit beta SB48_HM08orf03515 ENOG4105EGS Mechanosensitive ion channel SB48_HM08orf03516 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family SB48_HM08orf03518 ENOG4107QKR Dehydrogenase SB48_HM08orf03521 ENOG4107RUY (E1 component), alpha subunit SB48_HM08orf03525 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) SB48_HM08orf03528 ENOG4107TXC Transcriptional regulator SB48_HM08orf03530 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) SB48_HM08orf03532 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) SB48_HM08orf03534 ENOG4108N5B 2-phosphosulfolactate phosphatase SB48_HM08orf03535 ENOG41061P3 phosphosulfolactate synthase SB48_HM08orf03539 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component SB48_HM08orf03542 ENOG4107Y80 Major Facilitator superfamily SB48_HM08orf03543 ENOG4105YA8 Transcriptional regulator SB48_HM08orf03557 ENOG4108RPX mosc domain containing protein SB48_HM08orf03563 ENOG4105DWF phosphomethylpyrimidine kinase SB48_HM08orf03565 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase SB48_HM08orf03571 ENOG4108W0I acetyltransferase SB48_HM08orf03584 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) SB48_HM08orf03591 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) SB48_HM08orf03597 ENOG4105EA8 2-Nitropropane dioxygenase SB48_HM08orf03609 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) SB48_HM08orf03610 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) SB48_HM08orf03620 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) SB48_HM08orf03623 ENOG4105K4P CoA-binding domain protein SB48_HM08orf03626 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) SB48_HM08orf03629 ENOG4105W8X HesB YadR YfhF-family protein SB48_HM08orf03632 ENOG4105MI2 SB48_HM08orf03636 ENOG41067CD Small, acid-soluble spore protein Tlp SB48_HM08orf03643 ENOG4108I0Z Aconitate hydratase SB48_HM08orf03644 ENOG410746C Acid-soluble spore protein O SB48_HM08orf03645 ENOG4105C88 aminopeptidase SB48_HM08orf03648 ENOG41076DU acid-soluble spore protein P SB48_HM08orf03654 ENOG4105CEY Amp-dependent synthetase and ligase SB48_HM08orf03655 ENOG41067MG lrgb family SB48_HM08orf03660 ENOG4105BZ1 (ABC) transporter SB48_HM08orf03661 ENOG4105BZ1 (ABC) transporter SB48_HM08orf03667 ENOG41080V3 Major Facilitator superfamily SB48_HM08orf03673 ENOG4108R1P SB48_HM08orf03679 ENOG4108RWP Major Facilitator Superfamily protein SB48_HM08orf03680 ENOG4105WAB arsR family transcriptional regulator SB48_HM08orf03683 ENOG4105D5G Transposase SB48_HM08orf03690 ENOG4105CJZ response regulator SB48_HM08orf03692 ENOG4105EWM Histidine kinase SB48_HM08orf03693 ENOG4105C19 ABC transporter SB48_HM08orf03701 ENOG4105EUJ GTP cyclohydrolase i SB48_HM08orf03706 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) SB48_HM08orf03710 ENOG4105DJ2 Major Facilitator Superfamily SB48_HM08orf03720 ENOG4105FR1 rard protein SB48_HM08orf03724 ENOG41066VF YeeE YedE family protein SB48_HM08orf03727 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase SB48_HM08orf03729 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) SB48_HM08orf03732 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) SB48_HM08orf03734 ENOG4105ECC imidazole-glycerol-phosphate dehydratase SB48_HM08orf03736 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) SB48_HM08orf03739 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) SB48_HM08orf03740 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) SB48_HM08orf03751 ENOG41069ER domain protein SB48_HM08orf03753 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) SB48_HM08orf03759 ENOG4108RAV Conserved protein SB48_HM08orf03765 ENOG4105C72 UPF0176 protein SB48_HM08orf03767 ENOG4105C9U ATP-dependent DNA helicase RecQ SB48_HM08orf03772 ENOG4108JYZ YitT family SB48_HM08orf03778 ENOG4105C26 Dehydrogenase SB48_HM08orf03779 ENOG4105C7S Dehydrogenase SB48_HM08orf03781 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 SB48_HM08orf03786 ENOG4105GR3 Histidine kinase SB48_HM08orf03787 ENOG4105CK6 Two component transcriptional regulator (Winged helix family SB48_HM08orf03792 ENOG4105C7Z Conserved Protein SB48_HM08orf03802 ENOG410841Q phosphoesterase PA-phosphatase related protein SB48_HM08orf03805 ENOG4105FDF Could be involved in DNA repair (By similarity) SB48_HM08orf03806 ENOG4105DQE DNA ligase SB48_HM08orf03808 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) SB48_HM08orf03814 ENOG4107QMU Mate efflux family protein SB48_HM08orf03818 ENOG4105K4I Scp-like extracellular SB48_HM08orf03826 ENOG4108VXD carboxy-peptidase SB48_HM08orf03836 ENOG4105VSD UPF0346 protein SB48_HM08orf03840 ENOG4105C8Q Methyl-accepting chemotaxis SB48_HM08orf03843 ENOG4105E0X reductase SB48_HM08orf03844 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) SB48_HM08orf03846 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B SB48_HM08orf03852 ENOG41090WU lipolytic protein G-D-S-L family SB48_HM08orf03853 ENOG4108UT2 hemolysin iii SB48_HM08orf03854 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) SB48_HM08orf03855 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) SB48_HM08orf03860 ENOG4108Y6J UPF0403 protein SB48_HM08orf03864 ENOG4105C5H ABC transporter SB48_HM08orf03869 ENOG4105CKU formyltetrahydrofolate synthetase SB48_HM08orf03871 ENOG4105KST dependent repressor SB48_HM08orf03881 ENOG4105CXI aluminum resistance protein SB48_HM08orf03883 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) SB48_HM08orf03885 ENOG4106F1P AAA ATPase, central domain protein SB48_HM08orf03891 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) SB48_HM08orf03899 ENOG4105X3H Excalibur domain protein SB48_HM08orf03902 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) SB48_HM08orf03904 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) SB48_HM08orf03909 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) SB48_HM08orf03915 ENOG4105C8Y Acetylornithine aminotransferase SB48_HM08orf03916 ENOG4105C26 Dehydrogenase SB48_HM08orf03922 ENOG4108JUB Transcriptional regulator SB48_HM08orf03924 ENOG4105CUB amino acid SB48_HM08orf03927 ENOG4105CFP Peptidase U32 SB48_HM08orf03928 ENOG4105XYU peptidase (U32 family) SB48_HM08orf03930 ENOG4105MCT stage V sporulation protein S SB48_HM08orf03934 ENOG4105D48 metallophosphoesterase SB48_HM08orf03935 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) SB48_HM08orf03940 ENOG4105CEV competence damage-inducible protein SB48_HM08orf03941 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase SB48_HM08orf03945 ENOG4105XZV Protein of unknown function (DUF3243) SB48_HM08orf03948 ENOG4108RKS Short-chain dehydrogenase reductase Sdr SB48_HM08orf03954 ENOG4105UIB (ABC) transporter SB48_HM08orf03956 ENOG4108JQ9 ABC transporter SB48_HM08orf03958 ENOG4105DIH basic membrane SB48_HM08orf03960 ENOG4105CNU cell division protein FtsK SB48_HM08orf03962 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit SB48_HM08orf03964 ENOG4105CN5 Metallo-Beta-Lactamase SB48_HM08orf03967 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) SB48_HM08orf03971 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) SB48_HM08orf03974 ENOG4108S0H Dipicolinic acid synthetase, b subunit SB48_HM08orf03975 ENOG4105E35 Dipicolinate synthase subunit A SB48_HM08orf03979 ENOG4105C1V Peptidase, M16 SB48_HM08orf03983 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) SB48_HM08orf03984 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) SB48_HM08orf03986 ENOG4105DTN riboflavin biosynthesis protein ribF SB48_HM08orf03989 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) SB48_HM08orf03991 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) SB48_HM08orf03992 ENOG4105W7A Protein of unknown function (DUF503) SB48_HM08orf03996 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) SB48_HM08orf03997 ENOG4105VHM ribosomal protein SB48_HM08orf03999 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination SB48_HM08orf04001 ENOG4105CHV Transcription elongation factor NusA SB48_HM08orf04002 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) SB48_HM08orf04004 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) SB48_HM08orf04008 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) SB48_HM08orf04011 ENOG4105DZP Membrane-associated zinc metalloprotease SB48_HM08orf04013 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) SB48_HM08orf04015 ENOG4105KNE Phosphatidate cytidylyltransferase SB48_HM08orf04017 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) SB48_HM08orf04023 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) SB48_HM08orf04024 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) SB48_HM08orf04026 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) SB48_HM08orf04028 ENOG4105CE9 30S ribosomal protein S2 SB48_HM08orf04033 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) SB48_HM08orf04036 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) SB48_HM08orf04038 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis SB48_HM08orf04041 ENOG4105CBS Chea signal transduction histidine kinase SB48_HM08orf04042 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) SB48_HM08orf04046 ENOG4105FZW flagellar biosynthesis regulator FlhF SB48_HM08orf04048 ENOG4105D7B Flagellar biosynthesis protein flha SB48_HM08orf04049 ENOG4105D00 flagellar biosynthetic protein flhB SB48_HM08orf04051 ENOG4105D19 Role in flagellar biosynthesis (By similarity) SB48_HM08orf04052 ENOG4105VS8 Flagellar biosynthetic protein fliq SB48_HM08orf04053 ENOG4105CN7 Flagellar biosynthetic protein FliP SB48_HM08orf04056 ENOG4107YTP response regulator receiver protein SB48_HM08orf04058 ENOG4105DD5 Flagellar motor switch protein SB48_HM08orf04059 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) SB48_HM08orf04063 ENOG4108JQA flagellar SB48_HM08orf04068 ENOG410822I Flagellar hook capping protein SB48_HM08orf04074 ENOG4106YF4 Flagellar biosynthesis chaperone SB48_HM08orf04079 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) SB48_HM08orf04082 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) SB48_HM08orf04084 ENOG4105VQ0 flagellar hook-basal body complex protein fliE SB48_HM08orf04085 ENOG4108ZC9 flagellar basal-body rod protein flgc SB48_HM08orf04087 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) SB48_HM08orf04089 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) SB48_HM08orf04091 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) SB48_HM08orf04093 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) SB48_HM08orf04095 ENOG4108HE4 integrase family SB48_HM08orf04105 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) SB48_HM08orf04106 ENOG4105C79 DNA protecting protein DprA SB48_HM08orf04108 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha SB48_HM08orf04109 ENOG4105CMV Succinyl-CoA synthetase subunit beta SB48_HM08orf04111 ENOG4105D00 flagellar biosynthetic protein flhB SB48_HM08orf04116 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) SB48_HM08orf04121 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) SB48_HM08orf04124 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) SB48_HM08orf04125 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) SB48_HM08orf04128 ENOG4108BW8 UPF0109 protein SB48_HM08orf04130 ENOG4105K5M 30s ribosomal protein S16 SB48_HM08orf04137 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) SB48_HM08orf04138 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) SB48_HM08orf04139 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) SB48_HM08orf04140 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) SB48_HM08orf04141 ENOG4105CHR reductase SB48_HM08orf04143 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase SB48_HM08orf04144 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) SB48_HM08orf04145 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) SB48_HM08orf04147 ENOG4105CB5 ATP-dependent DNA helicase recG SB48_HM08orf04149 ENOG4105EJQ L-serine dehydratase SB48_HM08orf04154 ENOG4105DP4 dak2 domain fusion protein ylov SB48_HM08orf04155 ENOG4108ZAA Alkaline-shock protein SB48_HM08orf04159 ENOG4105FJ0 thiamine SB48_HM08orf04161 ENOG4105DJV ribulose-phosphate 3-epimerase SB48_HM08orf04163 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) SB48_HM08orf04164 ENOG4105D9P serine threonine protein kinase SB48_HM08orf04165 ENOG4108ZF3 Phosphatase SB48_HM08orf04167 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B SB48_HM08orf04169 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) SB48_HM08orf04170 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) SB48_HM08orf04172 ENOG4105C25 Primosomal protein n' SB48_HM08orf04174 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase SB48_HM08orf04177 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) SB48_HM08orf04178 ENOG4105KC4 UPF0296 protein SB48_HM08orf04179 ENOG4105DSJ YicC domain protein SB48_HM08orf04183 ENOG4105F23 Fibronectin-binding protein SB48_HM08orf04186 ENOG4105C09 Bile acid SB48_HM08orf04190 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) SB48_HM08orf04195 ENOG4105CT4 transporter SB48_HM08orf04210 ENOG410667J hydrolase SB48_HM08orf04211 ENOG4105C02 permease SB48_HM08orf04213 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component SB48_HM08orf04215 ENOG4108HW3 (ABC) transporter SB48_HM08orf04219 ENOG4105KPY Small multidrug resistance protein SB48_HM08orf04221 ENOG4105J7D transcriptional regulator SB48_HM08orf04222 ENOG4105C0R drug resistance transporter emrb qaca subfamily SB48_HM08orf04223 ENOG4105C0R drug resistance transporter emrb qaca subfamily SB48_HM08orf04224 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase SB48_HM08orf04228 ENOG4108Z5K methylglyoxal synthase SB48_HM08orf04232 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) SB48_HM08orf04234 ENOG4105DKG l-rhamnose isomerase SB48_HM08orf04236 ENOG4105DET Rhamnulokinase SB48_HM08orf04237 ENOG4105W4W Transcriptional regulator SB48_HM08orf04249 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) SB48_HM08orf04250 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) SB48_HM08orf04251 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) SB48_HM08orf04257 ENOG4105CD3 dihydroorotase SB48_HM08orf04259 ENOG4105CXT aspartate transcarbamylase SB48_HM08orf04261 ENOG4105EKQ RNA-directed DNA polymerase SB48_HM08orf04262 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) SB48_HM08orf04265 ENOG4105C34 Pseudouridine synthase SB48_HM08orf04267 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) SB48_HM08orf04274 ENOG4105DBK s4 domain protein SB48_HM08orf04275 ENOG41067XK integral membrane protein SB48_HM08orf04277 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) SB48_HM08orf04278 ENOG4105DFA alanine racemase domain protein SB48_HM08orf04279 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase SB48_HM08orf04280 ENOG41069ER domain protein SB48_HM08orf04281 ENOG4105WR5 sporulation protein, YlmC YmxH family SB48_HM08orf04284 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) SB48_HM08orf04287 ENOG4108AWX Sporulation factor SpoIIGA SB48_HM08orf04289 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) SB48_HM08orf04292 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) SB48_HM08orf04296 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) SB48_HM08orf04298 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) SB48_HM08orf04299 ENOG4105CNI cell division protein FtsW SB48_HM08orf04301 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) SB48_HM08orf04302 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) SB48_HM08orf04306 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) SB48_HM08orf04309 ENOG4105CJN penicillin-binding protein SB48_HM08orf04310 ENOG4105CJN penicillin-binding protein SB48_HM08orf04313 ENOG41068DC Essential cell division protein (By similarity) SB48_HM08orf04314 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) SB48_HM08orf04316 ENOG4108V6E Cell division protein mraZ SB48_HM08orf04322 ENOG41074B2 UPF0747 protein SB48_HM08orf04324 ENOG4107S3C Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) SB48_HM08orf04326 ENOG4108YG3 N-acetyltransferase SB48_HM08orf04329 ENOG41067VY 50S ribosomal protein L32 SB48_HM08orf04330 ENOG4105KNH Nucleic acid-binding protein SB48_HM08orf04332 ENOG4105CDE UPF0348 protein SB48_HM08orf04338 ENOG41063PX domain protein SB48_HM08orf04339 ENOG4105D78 K07001 NTE family protein SB48_HM08orf04341 ENOG4105H20 Sporulation integral membrane protein YlbJ SB48_HM08orf04345 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) SB48_HM08orf04346 ENOG4106H78 methyltransferase SB48_HM08orf04352 ENOG4105WUC UPF0298 protein SB48_HM08orf04364 ENOG4108VUY thioesterase Superfamily protein SB48_HM08orf04366 ENOG4106UY4 Inherit from COG: Scp-like extracellular SB48_HM08orf04371 ENOG41064X9 cytochrome C oxidase subunit IV SB48_HM08orf04377 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) SB48_HM08orf04380 ENOG4105CNI cell division protein FtsW SB48_HM08orf04384 ENOG4108IAB Phoh family SB48_HM08orf04387 ENOG4105QA2 SB48_HM08orf04390 ENOG4105CI3 gtp-binding protein typa SB48_HM08orf04392 ENOG4105ECY inositol monophosphatase SB48_HM08orf04397 ENOG4105WBI UPF0223 protein SB48_HM08orf04400 ENOG4105CXN decarboxylase SB48_HM08orf04414 ENOG4106148 UPF0356 protein SB48_HM08orf04415 ENOG4105CN5 Metallo-Beta-Lactamase SB48_HM08orf04422 ENOG4105CH2 amidohydrolase SB48_HM08orf04423 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) SB48_HM08orf04429 ENOG4107IN1 Protein of unknown function (DUF1797) SB48_HM08orf04436 ENOG4105K6S Short-chain dehydrogenase reductase Sdr SB48_HM08orf04445 ENOG4105EYF MMPL domain protein SB48_HM08orf04447 ENOG4105UIN SB48_HM08orf04449 ENOG4107R88 Chemotaxis protein (CheV) SB48_HM08orf04452 ENOG4105CHM Aminotransferase SB48_HM08orf04457 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase SB48_HM08orf04458 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr SB48_HM08orf04462 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) SB48_HM08orf04463 ENOG4105KRI phosphocarrier protein (HPr SB48_HM08orf04474 ENOG4108K88 Membrane SB48_HM08orf04487 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) SB48_HM08orf04493 ENOG4105BZU Histidine kinase SB48_HM08orf04500 ENOG410681C small acid-soluble spore protein SB48_HM08orf04504 ENOG4107TS3 membrane protein, TerC SB48_HM08orf04508 ENOG4105EKQ RNA-directed DNA polymerase SB48_HM08orf04510 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) SB48_HM08orf04512 ENOG4105BZU Histidine kinase SB48_HM08orf04514 ENOG4105EE0 oxidoreductase SB48_HM08orf04519 ENOG4105HUF DNA protection during starvation protein SB48_HM08orf04536 ENOG4105CYX Short-chain dehydrogenase reductase Sdr SB48_HM08orf04558 ENOG4107URF beta-phospho-glucomutase SB48_HM08orf04563 ENOG4107KJX Transcriptional regulator SB48_HM08orf04577 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) SB48_HM08orf04582 ENOG4107XVH Transcriptional regulator SB48_HM08orf04588 ENOG4105CAH Chromate SB48_HM08orf04591 ENOG4105FGV Chromate SB48_HM08orf04592 ENOG4105EKQ RNA-directed DNA polymerase SB48_HM08orf04594 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) SB48_HM08orf04600 ENOG4107QMH DNA methylase SB48_HM08orf04609 ENOG4105DPN Oligoendopeptidase f SB48_HM08orf04612 ENOG4105CTZ aminopeptidase c SB48_HM08orf04619 ENOG4105RHA ABC transporter, permease SB48_HM08orf04620 ENOG4108IUX (ABC) transporter SB48_HM08orf04623 ENOG41061TZ Short-chain dehydrogenase reductase Sdr SB48_HM08orf04626 ENOG4105EVU fructokinase SB48_HM08orf04648 ENOG4108ZMI UPF0477 protein SB48_HM08orf04671 ENOG4105CZ3 stage V sporulation protein ad SB48_HM08orf04673 ENOG41090VF Stage v sporulation protein ac SB48_HM08orf04687 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH SB48_HM08orf04688 ENOG4107S1Q Phosphatase SB48_HM08orf04693 ENOG4105EMS pseudouridine synthase SB48_HM08orf04694 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) SB48_HM08orf04702 ENOG4105E4C Lytic transglycosylase catalytic SB48_HM08orf04723 ENOG4108Z18 K06886 hemoglobin SB48_HM08orf04724 ENOG4105T58 Dithiol-disulfide isomerase SB48_HM08orf04732 ENOG4105DPN Oligoendopeptidase f SB48_HM08orf04736 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis SB48_HM08orf04740 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) SB48_HM08orf04742 ENOG4108JQ7 (ABC) transporter SB48_HM08orf04744 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component SB48_HM08orf04745 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component SB48_HM08orf04746 ENOG4108J59 Extracellular solute-binding protein, family 5 SB48_HM08orf04752 ENOG4105C31 Tryptophanyl-tRNA synthetase SB48_HM08orf04756 ENOG4105HJK ABC transporter SB48_HM08orf04760 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component SB48_HM08orf04761 ENOG4108JQ7 (ABC) transporter SB48_HM08orf04769 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) SB48_HM08orf04772 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) SB48_HM08orf04786 ENOG4105VG1 fes assembly suf system protein SB48_HM08orf04788 ENOG4108KP7 hydrolase SB48_HM08orf04792 ENOG41073B9 SB48_HM08orf04797 ENOG4105EPR degv family SB48_HM08orf04804 ENOG4105ERH Fumarylacetoacetate hydrolase SB48_HM08orf04806 ENOG4105DHF Membrane SB48_HM08orf04818 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation SB48_HM08orf04820 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination SB48_HM08orf04831 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 SB48_HM08orf04833 ENOG4108UMN azlc family SB48_HM08orf04836 ENOG4105CEY Amp-dependent synthetase and ligase SB48_HM08orf04838 ENOG4105DF9 Lipoate-protein, ligase SB48_HM08orf04839 ENOG4106AXD SB48_HM08orf04843 ENOG4108KF3 Electron transport protein SCO1 SenC SB48_HM08orf04845 ENOG4105C26 Dehydrogenase SB48_HM08orf04848 ENOG4108TVT permease SB48_HM08orf04852 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) SB48_HM08orf04854 ENOG4105E98 transcriptional regulator DeoR family SB48_HM08orf04855 ENOG4105C5Y PTS System SB48_HM08orf04855 ENOG4105C5Y PTS System SB48_HM08orf04856 ENOG4105ECB domain protein SB48_HM08orf04861 ENOG4105C1Q protoporphyrinogen oxidase SB48_HM08orf04863 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) SB48_HM08orf04864 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) SB48_HM08orf04868 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation SB48_HM08orf04881 ENOG4105K59 histidine triad (HIT) protein SB48_HM08orf04883 ENOG4105NBU tryptophan transport protein SB48_HM08orf04895 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) SB48_HM08orf04898 ENOG4105EQI Metal Dependent Phosphohydrolase SB48_HM08orf04899 ENOG4106D4I domain protein SB48_HM08orf04901 ENOG4107VRP DNA repair exonuclease SB48_HM08orf04904 ENOG4108PJD permease SB48_HM08orf04907 ENOG4108ZCF integral membrane protein SB48_HM08orf04911 ENOG4105CGU Enoyl-CoA hydratase SB48_HM08orf04916 ENOG4108UH6 UPF0754 membrane protein SB48_HM08orf04921 ENOG410839P SB48_HM08orf04928 ENOG4105YWU small acid-soluble spore protein SB48_HM08orf04929 ENOG4105C9Q fumarate hydratase class II SB48_HM08orf04938 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) SB48_HM08orf04940 ENOG4105KRI phosphocarrier protein (HPr SB48_HM08orf04944 ENOG4105CHW UPF0052 protein SB48_HM08orf04947 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) SB48_HM08orf04948 ENOG4108Z4K mutator MutT protein SB48_HM08orf04954 ENOG4105C3M thioredoxin reductase SB48_HM08orf04959 ENOG4108S4C acetyltransferase SB48_HM08orf04961 ENOG4107XGZ Hydrolase SB48_HM08orf04968 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) SB48_HM08orf04972 ENOG4108PY7 SB48_HM08orf04976 ENOG4107SJB teichoic acid biosynthesis SB48_HM08orf04980 ENOG4107SJB teichoic acid biosynthesis SB48_HM08orf04986 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase SB48_HM08orf04990 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) SB48_HM08orf04992 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) SB48_HM08orf05008 ENOG410838F Glycosyl transferase family 2 SB48_HM08orf05011 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) SB48_HM08orf05013 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) SB48_HM08orf05016 ENOG4105E2Z phosphate ABC transporter (Permease SB48_HM08orf05017 ENOG4105C8U phosphate abc transporter SB48_HM08orf05025 ENOG4105CVA phosphate SB48_HM08orf05028 ENOG4105C1Q protoporphyrinogen oxidase SB48_HM08orf05034 ENOG4105BZU Histidine kinase SB48_HM08orf05035 ENOG4105DPZ Two component transcriptional regulator (Winged helix family SB48_HM08orf05043 ENOG4108IPW abc transporter atp-binding protein SB48_HM08orf05044 ENOG4105CM4 permease protein SB48_HM08orf05045 ENOG4105DHS permease protein SB48_HM08orf05054 ENOG4105CN1 protease SB48_HM08orf05056 ENOG4105D6E homoserine dehydrogenase SB48_HM08orf05062 ENOG4105DR5 peptidase SB48_HM08orf05063 ENOG4105CRP Part of the ABC transporter FtsEX involved in SB48_HM08orf05065 ENOG4105CAK Cell division ATP-binding protein ftsE SB48_HM08orf05070 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) SB48_HM08orf05071 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) SB48_HM08orf05074 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving SB48_HM08orf05079 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) SB48_HM08orf05085 ENOG4105MQ3 flagellar protein FliS SB48_HM08orf05086 ENOG4107RT6 flagellar hook-associated SB48_HM08orf05088 ENOG41083S7 flagellar protein FlaG SB48_HM08orf05096 ENOG4108VX5 3-methyladenine DNA glycosylase SB48_HM08orf05102 ENOG4105DAN ATP-dependent protease SB48_HM08orf05106 ENOG4105C85 amino acid SB48_HM08orf05111 ENOG4105C85 amino acid SB48_HM08orf05112 ENOG4105C54 Major Facilitator superfamily SB48_HM08orf05115 ENOG4105D4U had-superfamily hydrolase, subfamily iia SB48_HM08orf05116 ENOG4105KT7 mgtC SapB transporter SB48_HM08orf05118 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator SB48_HM08orf05120 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving SB48_HM08orf05122 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) SB48_HM08orf05123 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) SB48_HM08orf05125 ENOG4105DTJ flagellar hook-associated protein SB48_HM08orf05127 ENOG4105E1Q flagellar hook-associated protein SB48_HM08orf05134 ENOG4105MJ2 Competence protein SB48_HM08orf05143 ENOG4105CUB amino acid SB48_HM08orf05148 ENOG4105WH1 Two component transcriptional regulator luxr family SB48_HM08orf05150 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein SB48_HM08orf05153 ENOG4105ESV Glycosyl transferase, family 4 SB48_HM08orf05157 ENOG4107RVG penicillin-binding protein SB48_HM08orf05158 ENOG4107SDU Methyl-accepting chemotaxis SB48_HM08orf05163 ENOG4105FDP GntR family transcriptional regulator SB48_HM08orf05166 ENOG4105CE4 GlcNAc 6-P deacetylase SB48_HM08orf05168 ENOG4105C0R drug resistance transporter emrb qaca subfamily SB48_HM08orf05172 ENOG4105CVG Homoserine O-transsuccinylase SB48_HM08orf05175 ENOG4105DG6 mannose-6-phosphate isomerase SB48_HM08orf05184 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase SB48_HM08orf05185 ENOG4105QNR S1 RNA binding domain protein SB48_HM08orf05196 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) SB48_HM08orf05200 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase SB48_HM08orf05202 ENOG4105CMR udp-glucose 4-epimerase SB48_HM08orf05203 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) SB48_HM08orf05208 ENOG4105FDT acyl-CoA dehydrogenase SB48_HM08orf05210 ENOG4105FDT acyl-CoA dehydrogenase SB48_HM08orf05213 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family SB48_HM08orf05215 ENOG4105EYF MMPL domain protein SB48_HM08orf05219 ENOG4105C0R drug resistance transporter emrb qaca subfamily SB48_HM08orf05220 ENOG4105C85 amino acid SB48_HM08orf05221 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) SB48_HM08orf05242 ENOG4105ETU transcriptional activator (TenA SB48_HM08orf05249 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) SB48_HM08orf05250 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) SB48_HM08orf05252 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) SB48_HM08orf05254 ENOG4105JSC dimethylmenaquinone methyltransferase SB48_HM08orf05257 ENOG4105CHM Aminotransferase SB48_HM08orf05268 ENOG4105UQX Mate efflux family protein SB48_HM08orf05269 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase SB48_HM08orf05270 ENOG4106D4I domain protein SB48_HM08orf05271 ENOG4107VRP DNA repair exonuclease SB48_HM08orf05273 ENOG4107V0Z fmn reductase SB48_HM08orf05282 ENOG4105CV8 reductase SB48_HM08orf05293 ENOG4108X4Q Hydrolase SB48_HM08orf05303 ENOG4105CPQ Dehydrogenase SB48_HM08orf05306 ENOG4105PGZ NB-ARC domain SB48_HM08orf05316 ENOG4107YZX Universal stress protein SB48_HM08orf05318 ENOG4108AQF aminoglycoside N(3)-acetyltransferase SB48_HM08orf05319 ENOG4105CYX Short-chain dehydrogenase reductase Sdr SB48_HM08orf05321 ENOG4105CSU acyl-Coa dehydrogenase SB48_HM08orf05322 ENOG4105CEY Amp-dependent synthetase and ligase SB48_HM08orf05332 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) SB48_HM08orf05344 ENOG4108EKI Dehydrogenase SB48_HM08orf05351 ENOG4108IA2 Sodium pantothenate symporter SB48_HM08orf05358 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase SB48_HM08orf05360 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) SB48_HM08orf05367 ENOG4105D6E homoserine dehydrogenase SB48_HM08orf05368 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) SB48_HM08orf05369 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) SB48_HM08orf05373 ENOG4107Z6I Thiamine biosynthesis protein SB48_HM08orf05375 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component SB48_HM08orf05377 ENOG4105DV0 amidase (EC 3.5.1.4 SB48_HM08orf05380 ENOG4105CR4 methylisocitrate lyase SB48_HM08orf05381 ENOG4105DXD 2-methylcitrate dehydratase SB48_HM08orf05390 ENOG4105F3R pts system mannose fructose sorbose family iid SB48_HM08orf05391 ENOG4105ETZ PTS System SB48_HM08orf05393 ENOG4108EQA pts system SB48_HM08orf05396 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family SB48_HM08orf05402 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) SB48_HM08orf05411 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) SB48_HM08orf05413 ENOG41069ER domain protein SB48_HM08orf05417 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) SB48_HM08orf05421 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) SB48_HM08orf05425 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) SB48_HM08orf05426 ENOG4108KGH TRANSCRIPTIONal SB48_HM08orf05427 ENOG4107YBY Hydrolase SB48_HM08orf05429 ENOG4105E2S oxidase) subunit II SB48_HM08orf05430 ENOG4105BZ9 Cytochrome C oxidase, subunit I SB48_HM08orf05432 ENOG41060D1 Quinol oxidase SB48_HM08orf05435 ENOG4107EXU Short-chain dehydrogenase reductase Sdr SB48_HM08orf05459 ENOG41075H3 AraC family transcriptional regulator SB48_HM08orf05460 ENOG4107T3P ABC, transporter SB48_HM08orf05469 ENOG4105C28 cystathionine SB48_HM08orf05470 ENOG4105C28 cystathionine SB48_HM08orf05474 ENOG4105CJ1 ABC, transporter SB48_HM08orf05476 ENOG4105C2X Arabinose 5-phosphate isomerase SB48_HM08orf05477 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase SB48_HM08orf05480 ENOG4105EMD TRANSCRIPTIONal SB48_HM08orf05481 ENOG4105CS2 ec 3.2.1.21 SB48_HM08orf05482 ENOG4105CK1 PTS System SB48_HM08orf05488 ENOG4105VCP PTS System SB48_HM08orf05509 ENOG4108KGH TRANSCRIPTIONal SB48_HM08orf05520 ENOG4105JXH GntR family transcriptional regulator SB48_HM08orf05521 ENOG4105DAA L-lactate SB48_HM08orf05523 ENOG4105CUB amino acid SB48_HM08orf05527 ENOG4106YYS transcriptional regulatory protein SB48_HM08orf05528 ENOG4105C2F Histidine kinase SB48_HM08orf05540 ENOG4105CN9 Peptidase m42 family protein SB48_HM08orf05546 ENOG41067SE Tetr family transcriptional regulator SB48_HM08orf05548 ENOG4105CEY Amp-dependent synthetase and ligase SB48_HM08orf05555 ENOG4105CJQ hydrolase, family 31 SB48_HM08orf05558 ENOG4108JUB Transcriptional regulator SB48_HM08orf05559 ENOG4105C0A alcohol dehydrogenase SB48_HM08orf05563 ENOG4105C26 Dehydrogenase SB48_HM08orf05565 ENOG4105CY2 Citrate transporter SB48_HM08orf05567 ENOG4105DTD Dehydrogenase SB48_HM08orf05580 ENOG4105TMB Formate nitrite transporter SB48_HM08orf05585 ENOG4108IYU L-aspartate oxidase SB48_HM08orf05586 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase SB48_HM08orf05589 ENOG4105C93 Xylose Isomerase SB48_HM08orf05591 ENOG4105CMG Carbohydrate kinase SB48_HM08orf05592 ENOG4105C54 Major Facilitator superfamily SB48_HM08orf05594 ENOG4107SCQ Iron-containing alcohol dehydrogenase SB48_HM08orf05602 ENOG4105C0P Mg chelatase subunit ChlI SB48_HM08orf05605 ENOG4105EBR Carboxylesterase SB48_HM08orf05609 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase SB48_HM08orf05610 ENOG4105EKQ RNA-directed DNA polymerase SB48_HM08orf05611 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) SB48_HM08orf05615 ENOG4105Q95 Cupin 2, conserved barrel domain protein SB48_HM08orf05624 ENOG4107JEE Short-chain dehydrogenase reductase Sdr SB48_HM08orf05626 ENOG4108UW5 maltose o-acetyltransferase SB48_HM08orf05628 ENOG4107HG4 Transcriptional regulator SB48_HM08orf05630 ENOG4108IJ8 ABC transporter SB48_HM08orf05632 ENOG4105E90 ABC transporter SB48_HM08orf05633 ENOG4108HQR Glycine betaine SB48_HM08orf05634 ENOG4105R40 Glycine betaine carnitine choline SB48_HM08orf05635 ENOG4105C4C beta-galactosidase SB48_HM08orf05638 ENOG4105CQ4 Transcriptional regulator SB48_HM08orf05640 ENOG4105CZM Major Facilitator SB48_HM08orf05642 ENOG4105EXW epimerase dehydratase SB48_HM08orf05643 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) SB48_HM08orf05648 ENOG4105C85 amino acid SB48_HM08orf05651 ENOG4107RBJ symporter SB48_HM08orf05652 ENOG4105CK1 PTS System SB48_HM08orf05655 ENOG4105VCP PTS System SB48_HM08orf05657 ENOG4105VZJ PTS System SB48_HM08orf05659 ENOG4105EMD TRANSCRIPTIONal SB48_HM08orf05663 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein SB48_HM08orf05667 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F SB48_HM08orf05677 ENOG4107QM2 Aldo Keto reductase SB48_HM08orf05680 ENOG4108KGH TRANSCRIPTIONal SB48_HM08orf05682 ENOG4107QTZ amino acid SB48_HM08orf05688 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 SB48_HM08orf05695 ENOG4105UNS Pfam:DUF419 SB48_HM08orf05696 ENOG4105EA8 2-Nitropropane dioxygenase SB48_HM08orf05697 ENOG4107RID 5-oxoprolinase (ATP-hydrolyzing) SB48_HM08orf05699 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin SB48_HM08orf05707 ENOG4105FB2 class II Aldolase SB48_HM08orf05709 ENOG4105DE4 1-phosphofructokinase SB48_HM08orf05712 ENOG4105DT3 PTS system, galactitol-specific IIc component SB48_HM08orf05713 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) SB48_HM08orf05718 ENOG4105F3R pts system mannose fructose sorbose family iid SB48_HM08orf05719 ENOG4105ETZ PTS System SB48_HM08orf05720 ENOG4108EQA pts system SB48_HM08orf05722 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family SB48_HM08orf05724 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin SB48_HM08orf05726 ENOG4107U7N hydantoinase B oxoprolinase SB48_HM08orf05728 ENOG4108IMY Transcriptional regulator SB48_HM08orf05731 ENOG4105FDP GntR family transcriptional regulator SB48_HM08orf05733 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) SB48_HM08orf05737 ENOG4108UZY PTS System SB48_HM08orf05738 ENOG4105ETZ PTS System SB48_HM08orf05739 ENOG4105F3R pts system mannose fructose sorbose family iid SB48_HM08orf05762 ENOG4105EDW glycosyl transferase, family 39 SB48_HM08orf05780 ENOG4105E2A Dehydrogenase SB48_HM08orf05787 ENOG4105CMG Carbohydrate kinase SB48_HM08orf05796 ENOG4105CMG Carbohydrate kinase SB48_HM08orf05798 ENOG4105C93 Xylose Isomerase SB48_HM08orf05801 ENOG4105CJQ hydrolase, family 31 SB48_HM08orf05808 ENOG4105C6Y Udp-glucose 6-dehydrogenase SB48_HM08orf05809 ENOG4105CJT Mannose-1-phosphate guanylyltransferase SB48_HM08orf05816 ENOG4105D3Q Sugar transferase SB48_HM08orf05817 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase SB48_HM08orf05818 ENOG4108RB3 Capsular polysaccharide biosynthesis protein SB48_HM08orf05819 ENOG4107YJ4 chain length determinant protein SB48_HM08orf05820 ENOG4105HTX biosynthesis protein SB48_HM08orf05842 ENOG4108RCF TRANSCRIPTIONal SB48_HM08orf05845 ENOG4107T5V SNARE associated Golgi SB48_HM08orf05846 ENOG4107ZTW SNARE associated Golgi SB48_HM08orf05852 ENOG4105KVH Transcriptional regulator SB48_HM08orf05857 ENOG4105DRP amino acid AbC transporter SB48_HM08orf05858 ENOG4105EAD ABC transporter SB48_HM08orf05860 ENOG4105CT1 (ABC) transporter SB48_HM08orf05867 ENOG4106F5Q Membrane SB48_HM08orf05872 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) SB48_HM08orf05874 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) SB48_HM08orf05877 ENOG4105C0X amino acid SB48_HM08orf05882 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) SB48_HM08orf05885 ENOG4105CPI Metal Dependent Phosphohydrolase SB48_HM08orf05895 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase SB48_HM08orf05900 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) SB48_HM08orf05909 ENOG4105IJJ transcriptional regulator, crp fnr family SB48_HM08orf05910 ENOG4107QJT sodium dicarboxylate symporter SB48_HM08orf05913 ENOG4105C6V Glycerol-3-phosphate dehydrogenase SB48_HM08orf05914 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) SB48_HM08orf05917 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator SB48_HM08orf05921 ENOG4105EEM helicase SB48_HM08orf05925 ENOG4105D4T Citrate transporter SB48_HM08orf05927 ENOG4108MRH transcriptional regulatory protein SB48_HM08orf05929 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism SB48_HM08orf05932 ENOG4105BZU Histidine kinase SB48_HM08orf05935 ENOG4107QW4 alcohol dehydrogenase SB48_HM08orf05938 ENOG4105D5Q Arginine ornithine antiporter SB48_HM08orf05942 ENOG4107SJI Dehydrogenase SB48_HM08orf05943 ENOG4105BZ8 glutamate synthase SB48_HM08orf05944 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease SB48_HM08orf05946 ENOG4105CE7 Amidase, hydantoinase carbamoylase family SB48_HM08orf05947 ENOG4105C0A alcohol dehydrogenase SB48_HM08orf05949 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) SB48_HM08orf05952 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) SB48_HM08orf05957 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) SB48_HM08orf05958 ENOG4105CUB amino acid SB48_HM08orf05980 ENOG4107RUE extracellular solute-binding protein family 1 SB48_HM08orf05981 ENOG4108EG7 Binding-protein-dependent transport systems, inner membrane component SB48_HM08orf05982 ENOG4105F38 ABC transporter, permease SB48_HM08orf05983 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) SB48_HM08orf05986 ENOG4108IQI permease SB48_HM08orf05987 ENOG4105DUX Transporter SB48_HM08orf05989 ENOG4105C85 amino acid SB48_HM08orf05993 ENOG4105CPC Aldo Keto reductase SB48_HM08orf06000 ENOG41080HJ 6-phospho 3-hexuloisomerase SB48_HM08orf06004 ENOG4105D7K pfkb domain protein SB48_HM08orf06007 ENOG4108M60 Transcriptional regulator SB48_HM08orf06011 ENOG4105CAG UPF0210 protein SB48_HM08orf06014 ENOG4105VUC UPF0237 protein SB48_HM08orf06020 ENOG4105C87 Aminotransferase class I and II SB48_HM08orf06026 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase SB48_HM08orf06028 ENOG4105ETD TRANSCRIPTIONal SB48_HM08orf06029 ENOG4105CTS PTS system mannitol-specific SB48_HM08orf06047 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) SB48_HM08orf06055 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) SB48_HM08orf06067 ENOG4105BZU Histidine kinase SB48_HM08orf06072 ENOG4105CEY Amp-dependent synthetase and ligase SB48_HM08orf06074 ENOG4105DCT glycerol dehydrogenase SB48_HM08orf06077 ENOG4108UIN ybak prolyl-trna synthetase associated region SB48_HM08orf06079 ENOG4108Z73 Siroheme synthase SB48_HM08orf06084 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein SB48_HM08orf06085 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) SB48_HM08orf06087 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) SB48_HM08orf06099 ENOG4105C26 Dehydrogenase SB48_HM08orf06106 ENOG41067SE Tetr family transcriptional regulator SB48_HM08orf06109 ENOG4105CHR reductase SB48_HM08orf06111 ENOG4105C1G acyl-Coa dehydrogenase SB48_HM08orf06114 ENOG4105CDY transcriptional regulatory protein SB48_HM08orf06124 ENOG4105CAY ferredoxin--nadp reductase SB48_HM08orf06126 ENOG4105E0A ABC, transporter SB48_HM08orf06130 ENOG4105DQ5 transport system permease protein SB48_HM08orf06131 ENOG4105EHG Permease protein SB48_HM08orf06135 ENOG41080TC multidrug resistance protein SB48_HM08orf06136 ENOG4108UZ3 Transporter SB48_HM08orf06148 ENOG4105CKK Glycosyl transferase, family 2 SB48_HM08orf06150 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) SB48_HM08orf06152 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) SB48_HM08orf06154 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) SB48_HM08orf06162 ENOG4105IJJ transcriptional regulator, crp fnr family SB48_HM08orf06164 ENOG4105BZU Histidine kinase SB48_HM08orf06169 ENOG4105NQC Flavodoxin SB48_HM08orf06179 ENOG4105CMG Carbohydrate kinase SB48_HM08orf06183 ENOG4105C6Z Gluconate SB48_HM08orf06185 ENOG4107414 GntR family transcriptional regulator SB48_HM08orf06187 ENOG4105CG3 alpha amylase, catalytic region SB48_HM08orf06189 ENOG4105C5Y PTS System SB48_HM08orf06190 ENOG4105C5Y PTS System SB48_HM08orf06193 ENOG4105E90 ABC transporter SB48_HM08orf06194 ENOG4108IJ8 ABC transporter SB48_HM08orf06207 ENOG4105CHU acetyl-coa acetyltransferase SB48_HM08orf06216 ENOG4106K7D Major facilitator family transporter SB48_HM08orf06225 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) SB48_HM08orf06234 ENOG4105DEN Luciferase family SB48_HM08orf06253 ENOG4105C8Q Methyl-accepting chemotaxis SB48_HM08orf06260 ENOG4106YBV Methyl-accepting chemotaxis SB48_HM08orf06261 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) SB48_HM08orf06263 ENOG4106P55 Transcriptional regulator SB48_HM08orf06264 ENOG4105F27 Major Facilitator SB48_HM08orf06287 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) SB48_HM08orf06292 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) SB48_HM08orf06294 ENOG4107U5W ybbr family SB48_HM08orf06295 ENOG4105C8B TIGR00159 family SB48_HM08orf06297 ENOG4105EMN RNA polymerase sigma factor SB48_HM08orf06302 ENOG41068JE domain protein SB48_HM08orf06344 ENOG4105CDU Replicative dna helicase SB48_HM08orf06345 ENOG4105PNS DnaD domain protein SB48_HM08orf06347 ENOG4108PNI recT protein SB48_HM08orf06348 ENOG4108NF7 phage-type endonuclease SB48_HM08orf06364 ENOG4107Y9E nuclease SB48_HM08orf06365 ENOG4107T65 Integrase SB48_HM08orf06367 ENOG41064X9 cytochrome C oxidase subunit IV SB48_HM08orf06373 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) SB48_HM08orf06377 ENOG4105CHR reductase SB48_HM08orf06379 ENOG4108JJ8 (ABC) transporter SB48_HM08orf06381 ENOG4108JJ9 ABC, transporter SB48_HM08orf06384 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii SB48_HM08orf06385 ENOG4105C4M (Ubiquinol oxidase) subunit I SB48_HM08orf06388 ENOG4108NMV polysaccharide deacetylase SB48_HM08orf06397 ENOG4105D1F ATP-binding protein SB48_HM08orf06400 ENOG4108IQI permease SB48_HM08orf06402 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) SB48_HM08orf06403 ENOG4107RIQ Sulfate adenylate transferase SB48_HM08orf06410 ENOG4108UJD 30S ribosomal protein S9 SB48_HM08orf06412 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) SB48_HM08orf06416 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) SB48_HM08orf06417 ENOG4108JJB ABC transporter SB48_HM08orf06418 ENOG4108JJB ABC transporter SB48_HM08orf06421 ENOG4108ZT0 50S ribosomal protein l17 SB48_HM08orf06422 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) SB48_HM08orf06423 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) SB48_HM08orf06425 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits SB48_HM08orf06426 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) SB48_HM08orf06429 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) SB48_HM08orf06431 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) SB48_HM08orf06432 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) SB48_HM08orf06435 ENOG4105VPB 50S ribosomal protein L30 SB48_HM08orf06436 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) SB48_HM08orf06438 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) SB48_HM08orf06440 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) SB48_HM08orf06441 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) SB48_HM08orf06445 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) SB48_HM08orf06446 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) SB48_HM08orf06447 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal SB48_HM08orf06448 ENOG41082SA 50s ribosomal protein l29 SB48_HM08orf06449 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) SB48_HM08orf06450 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) SB48_HM08orf06451 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) SB48_HM08orf06452 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) SB48_HM08orf06453 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity SB48_HM08orf06455 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) SB48_HM08orf06457 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) SB48_HM08orf06459 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) SB48_HM08orf06460 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) SB48_HM08orf06463 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) SB48_HM08orf06464 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) SB48_HM08orf06465 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) SB48_HM08orf06467 ENOG4105XPM ribosomal protein SB48_HM08orf06470 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) SB48_HM08orf06475 ENOG4107Y49 methyltransferase SB48_HM08orf06476 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) SB48_HM08orf06478 ENOG4108VZM 50s ribosomal protein L10 SB48_HM08orf06481 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) SB48_HM08orf06482 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) SB48_HM08orf06483 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) SB48_HM08orf06484 ENOG410683Z Preprotein translocase SecE subunit SB48_HM08orf06487 ENOG4105QIV RNA polymerase SB48_HM08orf06488 ENOG4105M0M Tetracycline resistance protein SB48_HM08orf06489 ENOG4105C2N RNA methyltransferase TrmH family group 3 SB48_HM08orf06491 ENOG4105C8N cysteinyl-tRNA synthetase SB48_HM08orf06492 ENOG4105D7W serine acetyltransferase SB48_HM08orf06495 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) SB48_HM08orf06501 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) SB48_HM08orf06502 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) SB48_HM08orf06503 ENOG4105CTP PilT protein domain protein SB48_HM08orf06506 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) SB48_HM08orf06508 ENOG41066A3 ATP guanido phosphotransferase SB48_HM08orf06510 ENOG4108Z0C Uvrb UvrC protein SB48_HM08orf06524 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) SB48_HM08orf06526 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) SB48_HM08orf06528 ENOG4105C6E dna polymerase iii SB48_HM08orf06530 ENOG4108Z6B deaminase SB48_HM08orf06540 ENOG4105VRS hydrolase family 18 SB48_HM08orf06543 ENOG4105ZMH deoxynucleoside kinase SB48_HM08orf06546 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) SB48_HM08orf06548 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) SB48_HM08orf06550 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) SB48_HM08orf06556 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) SB48_HM08orf06569 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase SB48_HM08orf06570 ENOG4105KRF dihydroneopterin aldolase SB48_HM08orf06571 ENOG4105EEI dihydropteroate synthase SB48_HM08orf06573 ENOG4105C6T cysteine synthase SB48_HM08orf06575 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) SB48_HM08orf06576 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) SB48_HM08orf06578 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) SB48_HM08orf06579 ENOG4108UGV hypoxanthine phosphoribosyltransferase SB48_HM08orf06580 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) SB48_HM08orf06592 ENOG41060GV RNA binding s1 domain protein SB48_HM08orf06595 ENOG4105VYY sporulation protein yabp SB48_HM08orf06597 ENOG41082I2 s4 domain protein SB48_HM08orf06599 ENOG4108IY2 MazG family SB48_HM08orf06604 ENOG4108M14 stage v sporulation protein t SB48_HM08orf06608 ENOG4108JA2 transcriptioN-repair coupling factor SB48_HM08orf06612 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) SB48_HM08orf06616 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) SB48_HM08orf06618 ENOG4105C5T Phosphoribosyl pyrophosphate synthase SB48_HM08orf06619 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) SB48_HM08orf06621 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) SB48_HM08orf06628 ENOG4105KME endoribonuclease L-psp SB48_HM08orf06630 ENOG4105DFT pur operon repressor SB48_HM08orf06632 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) SB48_HM08orf06635 ENOG4105W42 Veg protein SB48_HM08orf06637 ENOG4105XFA sporulation peptidase YabG SB48_HM08orf06639 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) SB48_HM08orf06641 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) SB48_HM08orf06643 ENOG4105F8V Hydrolase, tatD family SB48_HM08orf06649 ENOG4105KRN Transcriptional regulator, abrb family SB48_HM08orf06652 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) SB48_HM08orf06653 ENOG4105VC4 domain protein SB48_HM08orf06654 ENOG41060K3 Methyltransferase SB48_HM08orf06656 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) SB48_HM08orf06657 ENOG4105MA4 psp1 domain protein SB48_HM08orf06659 ENOG4105FA2 dna polymerase iii SB48_HM08orf06660 ENOG4105XVJ Protein of unknown function (DUF327) SB48_HM08orf06662 ENOG4105X0R protein from nitrogen regulatory protein P-II SB48_HM08orf06665 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) SB48_HM08orf06666 ENOG4105CXN decarboxylase SB48_HM08orf06669 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase SB48_HM08orf06671 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) SB48_HM08orf06673 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) SB48_HM08orf06678 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) SB48_HM08orf06680 ENOG410848D S4 domain protein YaaA SB48_HM08orf06682 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)