locus-tag	class	description
SB48_HM08orf00002	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SB48_HM08orf00004	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SB48_HM08orf00005	COG0594	ribonuclease P activity
SB48_HM08orf00006	COG0706	membrane insertase activity
SB48_HM08orf00007	COG1847	R3H domain protein
SB48_HM08orf00010	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SB48_HM08orf00012	COG0445	tRNA wobble uridine modification
SB48_HM08orf00014	COG0357	Ribosomal RNA small subunit methyltransferase G
SB48_HM08orf00016	COG1475	DNA binding
SB48_HM08orf00019	COG1192	Involved in chromosome partitioning
SB48_HM08orf00020	COG1475	DNA binding
SB48_HM08orf00028	COG0668	transmembrane transport
SB48_HM08orf00029	COG4481	Protein conserved in bacteria
SB48_HM08orf00030	COG0012	GTP binding
SB48_HM08orf00031	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SB48_HM08orf00031	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SB48_HM08orf00032	COG0307	riboflavin synthase, alpha
SB48_HM08orf00035	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SB48_HM08orf00037	COG0360	Binds together with S18 to 16S ribosomal RNA
SB48_HM08orf00039	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SB48_HM08orf00042	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
SB48_HM08orf00043	COG0359	binds to the 23S rRNA
SB48_HM08orf00047	COG0305	Participates in initiation and elongation during chromosome replication
SB48_HM08orf00050	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SB48_HM08orf00053	COG0745	RESPONSE REGULATOR receiver
SB48_HM08orf00054	COG5002	protein histidine kinase activity
SB48_HM08orf00055	COG4863	YycH protein
SB48_HM08orf00056	COG4853	Protein conserved in bacteria
SB48_HM08orf00057	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SB48_HM08orf00059	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SB48_HM08orf00062	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SB48_HM08orf00068	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SB48_HM08orf00073	COG1280	lysine exporter protein (LysE YggA)
SB48_HM08orf00085	COG3328	transposase activity
SB48_HM08orf00087	COG2329	Antibiotic biosynthesis monooxygenase
SB48_HM08orf00095	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SB48_HM08orf00096	COG0732	type I restriction modification DNA specificity domain
SB48_HM08orf00097	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SB48_HM08orf00098	COG0579	oxidoreductase
SB48_HM08orf00102	COG0765	amino acid transport
SB48_HM08orf00104	COG1126	abc transporter atp-binding protein
SB48_HM08orf00109	COG3457	Alanine racemase
SB48_HM08orf00118	COG1126	abc transporter atp-binding protein
SB48_HM08orf00122	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SB48_HM08orf00123	COG1366	Belongs to the anti-sigma-factor antagonist family
SB48_HM08orf00124	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SB48_HM08orf00125	COG2188	Transcriptional regulator
SB48_HM08orf00136	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SB48_HM08orf00140	COG1132	(ABC) transporter
SB48_HM08orf00142	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SB48_HM08orf00145	COG0028	Belongs to the TPP enzyme family
SB48_HM08orf00150	COG2814	Major facilitator Superfamily
SB48_HM08orf00156	COG2195	Cleaves the N-terminal amino acid of tripeptides
SB48_HM08orf00157	COG1442	glycosyl transferase family 8
SB48_HM08orf00160	COG0534	Mate efflux family protein
SB48_HM08orf00165	COG1119	ATPase activity
SB48_HM08orf00168	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SB48_HM08orf00170	COG2011	ABC-type metal ion transport system permease component
SB48_HM08orf00171	COG1464	Belongs to the NlpA lipoprotein family
SB48_HM08orf00172	COG3275	phosphorelay sensor kinase activity
SB48_HM08orf00174	COG1966	Carbon starvation protein
SB48_HM08orf00177	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SB48_HM08orf00179	COG2966	Psort location CytoplasmicMembrane, score
SB48_HM08orf00190	COG0367	asparagine synthase
SB48_HM08orf00192	COG0583	DNA-binding transcription factor activity
SB48_HM08orf00193	COG1380	Effector of murein hydrolase LrgA
SB48_HM08orf00194	COG1346	cytolysis
SB48_HM08orf00198	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SB48_HM08orf00203	COG1737	Transcriptional regulator
SB48_HM08orf00205	COG1785	Belongs to the alkaline phosphatase family
SB48_HM08orf00207	COG0514	ATP-dependent DNA helicase (RecQ)
SB48_HM08orf00208	COG0561	phosphatase activity
SB48_HM08orf00214	COG0351	phosphomethylpyrimidine kinase
SB48_HM08orf00222	COG4555	ABC transporter
SB48_HM08orf00226	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SB48_HM08orf00231	COG2363	Small membrane protein
SB48_HM08orf00237	COG0280	phosphate acetyltransferase
SB48_HM08orf00239	COG0095	Lipoate-protein ligase
SB48_HM08orf00247	COG1078	dGTPase activity
SB48_HM08orf00248	COG3465	dGTPase activity
SB48_HM08orf00251	COG1994	Peptidase M50
SB48_HM08orf00256	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SB48_HM08orf00258	COG0010	Belongs to the arginase family
SB48_HM08orf00261	COG0018	arginyl-trna synthetase
SB48_HM08orf00262	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SB48_HM08orf00266	COG0247	lactate metabolic process
SB48_HM08orf00266	COG2181	nitrate reductase activity
SB48_HM08orf00270	COG0183	Belongs to the thiolase family
SB48_HM08orf00273	COG1960	acyl-CoA dehydrogenase activity
SB48_HM08orf00274	COG1960	acyl-CoA dehydrogenase activity
SB48_HM08orf00276	COG1309	transcriptional regulator
SB48_HM08orf00279	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SB48_HM08orf00279	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SB48_HM08orf00279	COG1703	isobutyryl-CoA mutase activity
SB48_HM08orf00283	COG1136	(ABC) transporter
SB48_HM08orf00287	COG3343	RNA polymerase activity
SB48_HM08orf00288	COG0504	CTP synthase activity
SB48_HM08orf00291	COG1725	Transcriptional regulator
SB48_HM08orf00293	COG1131	(ABC) transporter
SB48_HM08orf00296	COG2204	response regulator
SB48_HM08orf00298	COG0191	fructose-bisphosphate aldolase activity
SB48_HM08orf00301	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SB48_HM08orf00305	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SB48_HM08orf00306	COG1494	fructose-1,6-bisphosphatase
SB48_HM08orf00310	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SB48_HM08orf00313	COG1435	thymidine kinase activity
SB48_HM08orf00315	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SB48_HM08orf00323	COG0009	L-threonylcarbamoyladenylate synthase
SB48_HM08orf00326	COG1971	Probably functions as a manganese efflux pump
SB48_HM08orf00332	COG0698	ribose 5-phosphate isomerase
SB48_HM08orf00337	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SB48_HM08orf00339	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SB48_HM08orf00343	COG0356	it plays a direct role in the translocation of protons across the membrane
SB48_HM08orf00344	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SB48_HM08orf00346	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SB48_HM08orf00347	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SB48_HM08orf00348	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SB48_HM08orf00350	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SB48_HM08orf00352	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SB48_HM08orf00354	COG4836	Membrane
SB48_HM08orf00358	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SB48_HM08orf00360	COG2385	sporulation resulting in formation of a cellular spore
SB48_HM08orf00362	COG0739	heme binding
SB48_HM08orf00364	COG1609	Transcriptional regulator
SB48_HM08orf00366	COG1077	Cell shape determining protein MreB Mrl
SB48_HM08orf00369	COG4786	Flagellar basal body rod
SB48_HM08orf00370	COG4786	Flagellar basal body rod
SB48_HM08orf00373	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SB48_HM08orf00378	COG0629	single-stranded DNA binding
SB48_HM08orf00381	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SB48_HM08orf00390	COG1253	flavin adenine dinucleotide binding
SB48_HM08orf00391	COG0789	Transcriptional regulator
SB48_HM08orf00393	COG1253	flavin adenine dinucleotide binding
SB48_HM08orf00398	COG1181	Belongs to the D-alanine--D-alanine ligase family
SB48_HM08orf00399	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SB48_HM08orf00404	COG1554	hydrolase, family 65, central catalytic
SB48_HM08orf00407	COG3833	ABC-type maltose transport systems, permease component
SB48_HM08orf00408	COG1175	transmembrane transport
SB48_HM08orf00412	COG2182	Extracellular solute-binding protein
SB48_HM08orf00417	COG1609	Transcriptional regulator
SB48_HM08orf00418	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SB48_HM08orf00421	COG1280	lysine exporter protein (LysE YggA)
SB48_HM08orf00426	COG0513	Belongs to the DEAD box helicase family
SB48_HM08orf00429	COG0705	Rhomboid family
SB48_HM08orf00430	COG0736	holo-[acyl-carrier-protein] synthase activity
SB48_HM08orf00431	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
SB48_HM08orf00436	COG0864	Transcriptional regulator
SB48_HM08orf00437	COG2337	Toxic component of a toxin-antitoxin (TA) module
SB48_HM08orf00443	COG1366	Belongs to the anti-sigma-factor antagonist family
SB48_HM08orf00444	COG1366	Belongs to the anti-sigma-factor antagonist family
SB48_HM08orf00445	COG2172	sigma factor antagonist activity
SB48_HM08orf00448	COG2208	phosphoserine phosphatase activity
SB48_HM08orf00449	COG1366	Belongs to the anti-sigma-factor antagonist family
SB48_HM08orf00451	COG2172	sigma factor antagonist activity
SB48_HM08orf00452	COG1191	sigma factor activity
SB48_HM08orf00453	COG2208	phosphoserine phosphatase activity
SB48_HM08orf00457	COG2183	response to ionizing radiation
SB48_HM08orf00460	COG3091	SprT-like family
SB48_HM08orf00465	COG0802	atpase or kinase
SB48_HM08orf00466	COG1214	PFAM Peptidase M22, glycoprotease
SB48_HM08orf00468	COG0456	acetyltransferase
SB48_HM08orf00474	COG0488	(ABC) transporter
SB48_HM08orf00476	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SB48_HM08orf00480	COG0805	protein transport
SB48_HM08orf00484	COG1266	CAAX protease self-immunity
SB48_HM08orf00488	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SB48_HM08orf00490	COG0459	protein refolding
SB48_HM08orf00492	COG2246	polysaccharide biosynthetic process
SB48_HM08orf00493	COG0463	Glycosyl transferase, family 2
SB48_HM08orf00498	COG4948	Mandelate Racemase Muconate Lactonizing
SB48_HM08orf00500	COG1335	isochorismatase
SB48_HM08orf00501	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SB48_HM08orf00503	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SB48_HM08orf00506	COG0519	Catalyzes the synthesis of GMP from XMP
SB48_HM08orf00506	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SB48_HM08orf00509	COG3620	sequence-specific DNA binding
SB48_HM08orf00512	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SB48_HM08orf00513	COG1120	ATPase activity
SB48_HM08orf00519	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_HM08orf00523	COG2391	methyltransferase activity
SB48_HM08orf00524	COG0425	Belongs to the sulfur carrier protein TusA family
SB48_HM08orf00532	COG1959	2 iron, 2 sulfur cluster binding
SB48_HM08orf00533	COG2910	NAD(P)H-binding
SB48_HM08orf00536	COG3479	Phenolic acid decarboxylase
SB48_HM08orf00537	COG1695	Transcriptional regulator
SB48_HM08orf00539	COG1725	Transcriptional regulator
SB48_HM08orf00540	COG1131	(ABC) transporter
SB48_HM08orf00548	COG0471	metal ion transport
SB48_HM08orf00552	COG0179	Fumarylacetoacetate (FAA) hydrolase
SB48_HM08orf00558	COG2814	Major facilitator Superfamily
SB48_HM08orf00559	COG2508	Transcriptional regulator
SB48_HM08orf00561	COG1250	3-hydroxyacyl-CoA dehydrogenase
SB48_HM08orf00566	COG0183	Belongs to the thiolase family
SB48_HM08orf00569	COG0318	PFAM AMP-dependent synthetase and ligase
SB48_HM08orf00570	COG0824	Thioesterase
SB48_HM08orf00576	COG0179	Fumarylacetoacetate (FAA) hydrolase
SB48_HM08orf00580	COG0842	Transport permease protein
SB48_HM08orf00583	COG1131	(ABC) transporter
SB48_HM08orf00585	COG3850	Histidine kinase
SB48_HM08orf00586	COG2197	response regulator
SB48_HM08orf00589	COG2814	Major facilitator Superfamily
SB48_HM08orf00591	COG1132	(ABC) transporter
SB48_HM08orf00595	COG2252	PERMEase
SB48_HM08orf00598	COG3711	transcriptional antiterminator
SB48_HM08orf00606	COG1301	dicarboxylic acid transport
SB48_HM08orf00616	COG1263	PTS System
SB48_HM08orf00616	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB48_HM08orf00620	COG2190	(PTS) system
SB48_HM08orf00620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB48_HM08orf00620	COG1263	PTS System
SB48_HM08orf00624	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SB48_HM08orf00626	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
SB48_HM08orf00630	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SB48_HM08orf00633	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SB48_HM08orf00634	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SB48_HM08orf00636	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SB48_HM08orf00637	COG0047	phosphoribosylformylglycinamidine synthase activity
SB48_HM08orf00639	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SB48_HM08orf00640	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SB48_HM08orf00641	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SB48_HM08orf00644	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SB48_HM08orf00645	COG0138	bifunctional purine biosynthesis protein purh
SB48_HM08orf00647	COG0151	Belongs to the GarS family
SB48_HM08orf00652	COG1470	cell adhesion involved in biofilm formation
SB48_HM08orf00654	COG4496	protein, YerC YecD
SB48_HM08orf00657	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
SB48_HM08orf00659	COG0210	DNA helicase
SB48_HM08orf00660	COG0210	DNA helicase
SB48_HM08orf00664	COG4851	CamS sex pheromone cAM373 precursor
SB48_HM08orf00666	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SB48_HM08orf00668	COG2224	Isocitrate lyase
SB48_HM08orf00670	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SB48_HM08orf00671	COG0154	amidase activity
SB48_HM08orf00673	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SB48_HM08orf00684	COG1597	lipid kinase activity
SB48_HM08orf00690	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SB48_HM08orf00712	COG3716	PTS system mannose fructose sorbose family IID component
SB48_HM08orf00723	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_HM08orf00724	COG2814	Major facilitator Superfamily
SB48_HM08orf00735	COG1064	alcohol dehydrogenase
SB48_HM08orf00739	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SB48_HM08orf00761	COG0326	Molecular chaperone. Has ATPase activity
SB48_HM08orf00768	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SB48_HM08orf00769	COG0765	amino acid transport
SB48_HM08orf00770	COG1126	abc transporter atp-binding protein
SB48_HM08orf00774	COG1764	response to oxidative stress
SB48_HM08orf00777	COG2814	Major facilitator Superfamily
SB48_HM08orf00779	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SB48_HM08orf00782	COG1984	allophanate hydrolase subunit 2
SB48_HM08orf00783	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SB48_HM08orf00788	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SB48_HM08orf00792	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SB48_HM08orf00798	COG2390	Transcriptional regulator
SB48_HM08orf00805	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SB48_HM08orf00811	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SB48_HM08orf00813	COG3328	transposase activity
SB48_HM08orf00822	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SB48_HM08orf00823	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SB48_HM08orf00824	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SB48_HM08orf00825	COG1116	anion transmembrane transporter activity
SB48_HM08orf00826	COG0431	NADPH-dependent FMN reductase
SB48_HM08orf00828	COG5583	Uncharacterized small protein (DUF2292)
SB48_HM08orf00830	COG3153	acetyltransferase
SB48_HM08orf00830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SB48_HM08orf00846	COG1012	belongs to the aldehyde dehydrogenase family
SB48_HM08orf00847	COG2814	Major facilitator Superfamily
SB48_HM08orf00849	COG0154	amidase activity
SB48_HM08orf00850	COG2272	Belongs to the type-B carboxylesterase lipase family
SB48_HM08orf00859	COG1388	LysM domain
SB48_HM08orf00859	COG0791	NLP P60 protein
SB48_HM08orf00863	COG1132	(ABC) transporter
SB48_HM08orf00866	COG1132	(ABC) transporter
SB48_HM08orf00870	COG3876	Protein conserved in bacteria
SB48_HM08orf00875	COG1472	Belongs to the glycosyl hydrolase 3 family
SB48_HM08orf00880	COG0697	spore germination
SB48_HM08orf00891	COG1278	Cold shock
SB48_HM08orf00893	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SB48_HM08orf00894	COG5002	protein histidine kinase activity
SB48_HM08orf00907	COG1609	Transcriptional regulator
SB48_HM08orf00908	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SB48_HM08orf00912	COG1276	copper resistance
SB48_HM08orf00912	COG2372	response to copper ion
SB48_HM08orf00913	COG4549	nuclear export factor GLE1
SB48_HM08orf00927	COG1609	Transcriptional regulator
SB48_HM08orf00928	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SB48_HM08orf00929	COG1869	D-ribose catabolic process
SB48_HM08orf00931	COG1129	ABC transporter
SB48_HM08orf00932	COG1172	Belongs to the binding-protein-dependent transport system permease family
SB48_HM08orf00934	COG1879	ABC-type sugar transport system periplasmic component
SB48_HM08orf00936	COG2610	gluconate transmembrane transporter activity
SB48_HM08orf00937	COG1929	Belongs to the glycerate kinase type-1 family
SB48_HM08orf00940	COG3835	regulator
SB48_HM08orf00943	COG1063	alcohol dehydrogenase
SB48_HM08orf00948	COG1328	CTP reductase activity
SB48_HM08orf00955	COG1301	dicarboxylic acid transport
SB48_HM08orf00957	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_HM08orf00959	COG3328	transposase activity
SB48_HM08orf00961	COG0281	malic enzyme
SB48_HM08orf00969	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SB48_HM08orf00969	COG0517	IMP dehydrogenase activity
SB48_HM08orf00970	COG1263	PTS System
SB48_HM08orf00970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB48_HM08orf00975	COG2190	(PTS) system
SB48_HM08orf00977	COG0386	Belongs to the glutathione peroxidase family
SB48_HM08orf00980	COG1280	lysine exporter protein (LysE YggA)
SB48_HM08orf00985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SB48_HM08orf00986	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SB48_HM08orf00987	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SB48_HM08orf00988	COG1126	abc transporter atp-binding protein
SB48_HM08orf00990	COG0765	amino acid transport
SB48_HM08orf00991	COG0765	amino acid transport
SB48_HM08orf00992	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SB48_HM08orf00995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SB48_HM08orf00996	COG0454	-acetyltransferase
SB48_HM08orf00998	COG0431	NADPH-dependent FMN reductase
SB48_HM08orf00999	COG0583	DNA-binding transcription factor activity
SB48_HM08orf01021	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SB48_HM08orf01024	COG1401	restriction endodeoxyribonuclease activity
SB48_HM08orf01026	COG4268	DNA restriction-modification system
SB48_HM08orf01030	COG3588	fructose-bisphosphate aldolase
SB48_HM08orf01032	COG2223	nitrite transmembrane transporter activity
SB48_HM08orf01034	COG2181	nitrate reductase activity
SB48_HM08orf01037	COG1140	nitrate reductase beta subunit
SB48_HM08orf01040	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
SB48_HM08orf01050	COG0833	amino acid
SB48_HM08orf01057	COG3829	transcription factor binding
SB48_HM08orf01060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SB48_HM08orf01062	COG1494	fructose-1,6-bisphosphatase
SB48_HM08orf01064	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SB48_HM08orf01065	COG0698	ribose 5-phosphate isomerase
SB48_HM08orf01067	COG1250	3-hydroxyacyl-CoA dehydrogenase
SB48_HM08orf01071	COG2271	Major facilitator Superfamily
SB48_HM08orf01074	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SB48_HM08orf01076	COG2376	Dihydroxyacetone kinase
SB48_HM08orf01078	COG1349	DNA-binding transcription factor activity
SB48_HM08orf01088	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SB48_HM08orf01091	COG1960	acyl-CoA dehydrogenase activity
SB48_HM08orf01097	COG0439	Biotin carboxylase
SB48_HM08orf01098	COG0511	ligase activity, forming carbon-carbon bonds
SB48_HM08orf01099	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SB48_HM08orf01101	COG1024	Enoyl-CoA hydratase
SB48_HM08orf01102	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SB48_HM08orf01113	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SB48_HM08orf01122	COG2233	PERMEase
SB48_HM08orf01124	COG0730	response to heat
SB48_HM08orf01127	COG1113	amino acid transport
SB48_HM08orf01129	COG0778	Nitroreductase
SB48_HM08orf01137	COG2376	Dihydroxyacetone kinase
SB48_HM08orf01139	COG1461	Dihydroxyacetone kinase
SB48_HM08orf01140	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SB48_HM08orf01147	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SB48_HM08orf01152	COG2357	RelA SpoT domain protein
SB48_HM08orf01159	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SB48_HM08orf01162	COG2814	Major facilitator Superfamily
SB48_HM08orf01168	COG0561	phosphatase activity
SB48_HM08orf01175	COG0371	Dehydrogenase
SB48_HM08orf01176	COG1349	DNA-binding transcription factor activity
SB48_HM08orf01181	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SB48_HM08orf01181	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SB48_HM08orf01181	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SB48_HM08orf01183	COG0025	NhaP-type Na H and K H
SB48_HM08orf01186	COG0166	Belongs to the GPI family
SB48_HM08orf01188	COG1304	FMN binding
SB48_HM08orf01206	COG1518	maintenance of DNA repeat elements
SB48_HM08orf01207	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SB48_HM08orf01209	COG3620	sequence-specific DNA binding
SB48_HM08orf01215	COG0737	Belongs to the 5'-nucleotidase family
SB48_HM08orf01216	COG4086	secreted protein
SB48_HM08orf01225	COG2197	response regulator
SB48_HM08orf01231	COG0860	N-Acetylmuramoyl-L-alanine amidase
SB48_HM08orf01233	COG0288	reversible hydration of carbon dioxide
SB48_HM08orf01234	COG2226	methyltransferase
SB48_HM08orf01237	COG1854	S-ribosylhomocysteine lyase activity
SB48_HM08orf01239	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SB48_HM08orf01240	COG0626	cystathionine gamma-synthase activity
SB48_HM08orf01243	COG1585	Membrane protein implicated in regulation of membrane protease activity
SB48_HM08orf01246	COG2268	Band 7 protein
SB48_HM08orf01250	COG1077	Cell shape determining protein MreB Mrl
SB48_HM08orf01253	COG1607	acyl-coa hydrolase
SB48_HM08orf01254	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SB48_HM08orf01257	COG3189	MarR family transcriptional regulator
SB48_HM08orf01262	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SB48_HM08orf01263	COG1360	Flagellar Motor Protein
SB48_HM08orf01264	COG0693	protein deglycase activity
SB48_HM08orf01266	COG0024	Methionine aminopeptidase
SB48_HM08orf01268	COG4840	Belongs to the UPF0435 family
SB48_HM08orf01269	COG1295	ribonuclease BN
SB48_HM08orf01270	COG0477	Major facilitator Superfamily
SB48_HM08orf01271	COG0387	Pfam Sodium calcium exchanger
SB48_HM08orf01282	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
SB48_HM08orf01283	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SB48_HM08orf01286	COG1846	Transcriptional regulator
SB48_HM08orf01288	COG1132	(ABC) transporter
SB48_HM08orf01290	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SB48_HM08orf01298	COG0840	transmembrane signaling receptor activity
SB48_HM08orf01301	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SB48_HM08orf01303	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SB48_HM08orf01304	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SB48_HM08orf01312	COG0477	Major facilitator Superfamily
SB48_HM08orf01315	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
SB48_HM08orf01321	COG2839	Protein conserved in bacteria
SB48_HM08orf01323	COG1823	symporter activity
SB48_HM08orf01326	COG3655	Transcriptional regulator
SB48_HM08orf01328	COG3739	integral membrane protein
SB48_HM08orf01330	COG5278	phosphoserine phosphatase activity
SB48_HM08orf01330	COG0840	transmembrane signaling receptor activity
SB48_HM08orf01347	COG1511	domain protein
SB48_HM08orf01349	COG1309	transcriptional regulator
SB48_HM08orf01352	COG2132	Multicopper oxidase
SB48_HM08orf01354	COG0252	asparaginase activity
SB48_HM08orf01358	COG3275	phosphorelay sensor kinase activity
SB48_HM08orf01359	COG3279	Response regulator of the LytR AlgR family
SB48_HM08orf01362	COG2223	nitrite transmembrane transporter activity
SB48_HM08orf01364	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SB48_HM08orf01366	COG0670	Belongs to the BI1 family
SB48_HM08orf01368	COG2124	cytochrome p450
SB48_HM08orf01373	COG1366	Belongs to the anti-sigma-factor antagonist family
SB48_HM08orf01374	COG1114	Component of the transport system for branched-chain amino acids
SB48_HM08orf01378	COG0129	dihydroxy-acid dehydratase activity
SB48_HM08orf01382	COG0028	Belongs to the TPP enzyme family
SB48_HM08orf01383	COG0440	acetolactate synthase activity
SB48_HM08orf01386	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SB48_HM08orf01388	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SB48_HM08orf01390	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SB48_HM08orf01393	COG0066	3-isopropylmalate dehydratase activity
SB48_HM08orf01394	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SB48_HM08orf01401	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SB48_HM08orf01403	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SB48_HM08orf01404	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SB48_HM08orf01406	COG0840	transmembrane signaling receptor activity
SB48_HM08orf01411	COG0058	SHG alpha-glucan phosphorylase activity
SB48_HM08orf01415	COG1012	belongs to the aldehyde dehydrogenase family
SB48_HM08orf01415	COG1012	belongs to the aldehyde dehydrogenase family
SB48_HM08orf01421	COG4585	Histidine kinase
SB48_HM08orf01422	COG2197	response regulator
SB48_HM08orf01431	COG1131	(ABC) transporter
SB48_HM08orf01435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SB48_HM08orf01436	COG1136	(ABC) transporter
SB48_HM08orf01436	COG0577	efflux transmembrane transporter activity
SB48_HM08orf01437	COG0577	efflux transmembrane transporter activity
SB48_HM08orf01444	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SB48_HM08orf01444	COG0512	Glutamine amidotransferase of anthranilate synthase
SB48_HM08orf01446	COG0134	indole-3-glycerol-phosphate synthase activity
SB48_HM08orf01447	COG0133	tryptophan synthase activity
SB48_HM08orf01449	COG0159	tryptophan synthase activity
SB48_HM08orf01466	COG1194	a g-specific adenine glycosylase
SB48_HM08orf01468	COG1988	membrane-bound metal-dependent
SB48_HM08orf01471	COG1131	(ABC) transporter
SB48_HM08orf01477	COG0493	'glutamate synthase
SB48_HM08orf01482	COG0067	glutamate synthase
SB48_HM08orf01482	COG0070	glutamate synthase
SB48_HM08orf01482	COG0069	glutamate synthase activity
SB48_HM08orf01483	COG0583	DNA-binding transcription factor activity
SB48_HM08orf01484	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_HM08orf01488	COG3557	Belongs to the UPF0374 family
SB48_HM08orf01489	COG1132	(ABC) transporter
SB48_HM08orf01492	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SB48_HM08orf01493	COG1263	PTS System
SB48_HM08orf01493	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB48_HM08orf01494	COG1737	Transcriptional regulator
SB48_HM08orf01496	COG4129	membrane
SB48_HM08orf01502	COG2814	Major facilitator Superfamily
SB48_HM08orf01504	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SB48_HM08orf01505	COG1116	anion transmembrane transporter activity
SB48_HM08orf01506	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SB48_HM08orf01507	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SB48_HM08orf01510	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SB48_HM08orf01516	COG0735	belongs to the Fur family
SB48_HM08orf01521	COG0583	DNA-binding transcription factor activity
SB48_HM08orf01523	COG0028	Belongs to the TPP enzyme family
SB48_HM08orf01524	COG3527	Alpha-acetolactate decarboxylase
SB48_HM08orf01533	COG2323	membrane
SB48_HM08orf01536	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SB48_HM08orf01544	COG0697	spore germination
SB48_HM08orf01550	COG2271	Major facilitator Superfamily
SB48_HM08orf01562	COG1846	Transcriptional regulator
SB48_HM08orf01563	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SB48_HM08orf01567	COG4555	ABC transporter
SB48_HM08orf01568	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SB48_HM08orf01569	COG3104	oligopeptide transport
SB48_HM08orf01579	COG3850	Histidine kinase
SB48_HM08orf01579	COG5002	protein histidine kinase activity
SB48_HM08orf01580	COG0745	RESPONSE REGULATOR receiver
SB48_HM08orf01590	COG1131	(ABC) transporter
SB48_HM08orf01597	COG0431	NADPH-dependent FMN reductase
SB48_HM08orf01599	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SB48_HM08orf01600	COG1882	Formate acetyltransferase
SB48_HM08orf01612	COG2116	formate transmembrane transporter activity
SB48_HM08orf01614	COG1126	abc transporter atp-binding protein
SB48_HM08orf01615	COG0765	amino acid transport
SB48_HM08orf01617	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SB48_HM08orf01618	COG0596	Alpha beta hydrolase
SB48_HM08orf01619	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
SB48_HM08orf01626	COG2095	MarC family integral membrane protein
SB48_HM08orf01632	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SB48_HM08orf01638	COG2766	serine protein kinase
SB48_HM08orf01640	COG2718	Belongs to the UPF0229 family
SB48_HM08orf01645	COG0306	phosphate transporter
SB48_HM08orf01647	COG1392	Phosphate transport regulator
SB48_HM08orf01655	COG3594	Acyltransferase
SB48_HM08orf01657	COG2719	SpoVR family
SB48_HM08orf01666	COG0598	Magnesium transport protein CorA
SB48_HM08orf01668	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SB48_HM08orf01670	COG0601	transmembrane transport
SB48_HM08orf01671	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SB48_HM08orf01673	COG0444	Belongs to the ABC transporter superfamily
SB48_HM08orf01676	COG4166	transmembrane transport
SB48_HM08orf01678	COG0791	NLP P60 protein
SB48_HM08orf01681	COG4608	Belongs to the ABC transporter superfamily
SB48_HM08orf01685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SB48_HM08orf01692	COG0840	transmembrane signaling receptor activity
SB48_HM08orf01698	COG3383	formate dehydrogenase (NAD+) activity
SB48_HM08orf01706	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SB48_HM08orf01714	COG0126	phosphoglycerate kinase activity
SB48_HM08orf01716	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SB48_HM08orf01719	COG0148	phosphopyruvate hydratase activity
SB48_HM08orf01724	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SB48_HM08orf01727	COG1647	Serine aminopeptidase, S33
SB48_HM08orf01728	COG0557	exoribonuclease II activity
SB48_HM08orf01735	COG0463	Glycosyl transferase, family 2
SB48_HM08orf01751	COG1414	Transcriptional regulator
SB48_HM08orf01754	COG0800	Aldolase
SB48_HM08orf01757	COG0246	Mannitol dehydrogenase
SB48_HM08orf01758	COG2721	sulfolactate sulfo-lyase activity
SB48_HM08orf01759	COG1904	glucuronate isomerase
SB48_HM08orf01761	COG2211	Major facilitator Superfamily
SB48_HM08orf01763	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_HM08orf01764	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
SB48_HM08orf01766	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SB48_HM08orf01779	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SB48_HM08orf01784	COG1595	DNA-templated transcription, initiation
SB48_HM08orf01792	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SB48_HM08orf01796	COG0671	phosphoesterase, PA-phosphatase related
SB48_HM08orf01798	COG0753	catalase activity
SB48_HM08orf01800	COG2199	diguanylate cyclase activity
SB48_HM08orf01800	COG2200	EAL domain
SB48_HM08orf01800	COG2202	Pas domain
SB48_HM08orf01804	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SB48_HM08orf01810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SB48_HM08orf01811	COG0772	Belongs to the SEDS family
SB48_HM08orf01813	COG5577	PFAM Coat F domain
SB48_HM08orf01820	COG1024	Enoyl-CoA hydratase
SB48_HM08orf01820	COG1250	3-hydroxyacyl-CoA dehydrogenase
SB48_HM08orf01822	COG0183	Belongs to the thiolase family
SB48_HM08orf01826	COG1960	acyl-CoA dehydrogenase activity
SB48_HM08orf01828	COG1393	Belongs to the ArsC family
SB48_HM08orf01829	COG0509	glycine decarboxylation via glycine cleavage system
SB48_HM08orf01830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SB48_HM08orf01838	COG0396	ATPase activity
SB48_HM08orf01839	COG0719	Fe-S assembly protein
SB48_HM08orf01841	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SB48_HM08orf01842	COG0822	iron-sulfur transferase activity
SB48_HM08orf01844	COG0719	Fe-S assembly protein
SB48_HM08orf01847	COG0737	Belongs to the 5'-nucleotidase family
SB48_HM08orf01848	COG3377	Domain of unknown function (DUF1805)
SB48_HM08orf01852	COG0739	heme binding
SB48_HM08orf01855	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SB48_HM08orf01857	COG4470	Protein conserved in bacteria
SB48_HM08orf01858	COG2445	Protein of unknown function DUF86
SB48_HM08orf01860	COG0647	UMP catabolic process
SB48_HM08orf01862	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SB48_HM08orf01864	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SB48_HM08orf01867	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SB48_HM08orf01869	COG4837	Protein of unknown function (DUF1462)
SB48_HM08orf01872	COG0316	Belongs to the HesB IscA family
SB48_HM08orf01884	COG0492	ferredoxin-NADP+ reductase activity
SB48_HM08orf01887	COG1252	NADH dehydrogenase
SB48_HM08orf01893	COG3584	3D domain protein
SB48_HM08orf01899	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SB48_HM08orf01901	COG0697	spore germination
SB48_HM08orf01903	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SB48_HM08orf01912	COG2050	protein possibly involved in aromatic compounds catabolism
SB48_HM08orf01914	COG2814	Major facilitator Superfamily
SB48_HM08orf01926	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SB48_HM08orf01937	COG0656	L-ascorbic acid biosynthetic process
SB48_HM08orf01943	COG1098	S1 RNA binding domain
SB48_HM08orf01952	COG2155	Conserved Protein
SB48_HM08orf01955	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SB48_HM08orf01963	COG1012	belongs to the aldehyde dehydrogenase family
SB48_HM08orf01972	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
SB48_HM08orf01975	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_HM08orf01985	COG0840	transmembrane signaling receptor activity
SB48_HM08orf01986	COG1609	Transcriptional regulator
SB48_HM08orf01992	COG4214	carbohydrate transport
SB48_HM08orf01994	COG4213	ABC transporter substrate-binding protein
SB48_HM08orf01995	COG1609	Transcriptional regulator
SB48_HM08orf01997	COG2160	L-arabinose isomerase activity
SB48_HM08orf01998	COG0235	Class ii aldolase
SB48_HM08orf02008	COG2190	(PTS) system
SB48_HM08orf02011	COG1525	nuclease
SB48_HM08orf02013	COG1937	Protein conserved in bacteria
SB48_HM08orf02014	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SB48_HM08orf02018	COG0038	chloride channel
SB48_HM08orf02020	COG3328	transposase activity
SB48_HM08orf02030	COG0726	polysaccharide deacetylase
SB48_HM08orf02042	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SB48_HM08orf02048	COG1522	sequence-specific DNA binding
SB48_HM08orf02052	COG2608	mercury ion transmembrane transporter activity
SB48_HM08orf02055	COG2217	Heavy metal translocating P-type atpase
SB48_HM08orf02066	COG1285	pathogenesis
SB48_HM08orf02072	COG1575	Belongs to the MenA family. Type 1 subfamily
SB48_HM08orf02074	COG1169	isochorismate synthase
SB48_HM08orf02076	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SB48_HM08orf02078	COG0596	Alpha beta hydrolase
SB48_HM08orf02079	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SB48_HM08orf02083	COG0318	PFAM AMP-dependent synthetase and ligase
SB48_HM08orf02084	COG4948	Mandelate Racemase Muconate Lactonizing
SB48_HM08orf02088	COG0803	Belongs to the bacterial solute-binding protein 9 family
SB48_HM08orf02093	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SB48_HM08orf02095	COG0783	Belongs to the Dps family
SB48_HM08orf02101	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SB48_HM08orf02102	COG1116	anion transmembrane transporter activity
SB48_HM08orf02103	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SB48_HM08orf02106	COG1070	Carbohydrate kinase
SB48_HM08orf02110	COG0655	NAD(P)H dehydrogenase (quinone) activity
SB48_HM08orf02111	COG1506	peptidase
SB48_HM08orf02115	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SB48_HM08orf02118	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SB48_HM08orf02122	COG0367	asparagine synthase
SB48_HM08orf02128	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SB48_HM08orf02130	COG2267	carboxylic ester hydrolase activity
SB48_HM08orf02138	COG0275	rRNA processing
SB48_HM08orf02144	COG2814	Major facilitator Superfamily
SB48_HM08orf02146	COG0495	leucyl-tRNA aminoacylation
SB48_HM08orf02153	COG2244	polysaccharide biosynthetic process
SB48_HM08orf02155	COG1349	DNA-binding transcription factor activity
SB48_HM08orf02159	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SB48_HM08orf02168	COG0510	thiamine kinase activity
SB48_HM08orf02170	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SB48_HM08orf02176	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SB48_HM08orf02179	COG5584	Small secreted protein
SB48_HM08orf02181	COG1363	Peptidase, m42
SB48_HM08orf02183	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
SB48_HM08orf02187	COG0784	Response regulator, receiver
SB48_HM08orf02187	COG5002	protein histidine kinase activity
SB48_HM08orf02189	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SB48_HM08orf02190	COG2208	phosphoserine phosphatase activity
SB48_HM08orf02193	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SB48_HM08orf02198	COG4848	Belongs to the UPF0354 family
SB48_HM08orf02200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SB48_HM08orf02206	COG1674	ftsk spoiiie
SB48_HM08orf02213	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SB48_HM08orf02218	COG4980	gas vesicle protein
SB48_HM08orf02222	COG1605	Chorismate mutase
SB48_HM08orf02222	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SB48_HM08orf02228	COG0123	including yeast histone deacetylase and acetoin utilization protein
SB48_HM08orf02230	COG0517	IMP dehydrogenase activity
SB48_HM08orf02231	COG0454	-acetyltransferase
SB48_HM08orf02233	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SB48_HM08orf02236	COG4149	molybdate abc transporter
SB48_HM08orf02237	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SB48_HM08orf02239	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SB48_HM08orf02244	COG0303	'Molybdopterin
SB48_HM08orf02246	COG1763	Mo-molybdopterin cofactor biosynthetic process
SB48_HM08orf02248	COG0314	molybdopterin synthase activity
SB48_HM08orf02250	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
SB48_HM08orf02251	COG0315	cyclic pyranopterin monophosphate synthase activity
SB48_HM08orf02252	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SB48_HM08orf02255	COG2427	Protein of unknown function (DUF1641)
SB48_HM08orf02257	COG3383	formate dehydrogenase (NAD+) activity
SB48_HM08orf02259	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SB48_HM08orf02266	COG3829	transcription factor binding
SB48_HM08orf02266	COG3290	protein histidine kinase activity
SB48_HM08orf02269	COG1012	belongs to the aldehyde dehydrogenase family
SB48_HM08orf02270	COG0506	proline dehydrogenase activity
SB48_HM08orf02272	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SB48_HM08orf02276	COG2203	Gaf domain
SB48_HM08orf02276	COG2199	diguanylate cyclase activity
SB48_HM08orf02278	COG1956	GAF domain-containing protein
SB48_HM08orf02279	COG1309	transcriptional regulator
SB48_HM08orf02282	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
SB48_HM08orf02283	COG1104	cysteine desulfurase activity
SB48_HM08orf02284	COG0301	tRNA thio-modification
SB48_HM08orf02286	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SB48_HM08orf02288	COG0616	signal peptide processing
SB48_HM08orf02289	COG1714	RDD family
SB48_HM08orf02293	COG3874	Sporulation protein YtfJ
SB48_HM08orf02296	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SB48_HM08orf02299	COG0827	DNA restriction-modification system
SB48_HM08orf02302	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SB48_HM08orf02307	COG0589	response to stress
SB48_HM08orf02313	COG0006	proline dipeptidase activity
SB48_HM08orf02314	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SB48_HM08orf02318	COG4109	DRTGG domain
SB48_HM08orf02321	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SB48_HM08orf02325	COG0587	DNA-directed DNA polymerase activity
SB48_HM08orf02326	COG0281	malic enzyme
SB48_HM08orf02328	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SB48_HM08orf02329	COG0825	malonyl-CoA metabolic process
SB48_HM08orf02331	COG0205	6-phosphofructokinase activity
SB48_HM08orf02334	COG0628	permease
SB48_HM08orf02335	COG2707	UPF0756 membrane protein
SB48_HM08orf02337	COG0372	Belongs to the citrate synthase family
SB48_HM08orf02338	COG0538	isocitrate dehydrogenase activity
SB48_HM08orf02340	COG0039	L-malate dehydrogenase activity
SB48_HM08orf02343	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SB48_HM08orf02343	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SB48_HM08orf02344	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SB48_HM08orf02347	COG1971	Probably functions as a manganese efflux pump
SB48_HM08orf02349	COG0237	dephospho-CoA kinase activity
SB48_HM08orf02350	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SB48_HM08orf02351	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SB48_HM08orf02352	COG3611	Membrane attachment protein
SB48_HM08orf02354	COG1484	DNA-dependent DNA replication
SB48_HM08orf02360	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SB48_HM08orf02366	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SB48_HM08orf02367	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SB48_HM08orf02369	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SB48_HM08orf02383	COG0431	NADPH-dependent FMN reductase
SB48_HM08orf02392	COG1695	Transcriptional regulator
SB48_HM08orf02394	COG2329	Antibiotic biosynthesis monooxygenase
SB48_HM08orf02403	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SB48_HM08orf02407	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SB48_HM08orf02409	COG0072	phenylalanine-tRNA ligase activity
SB48_HM08orf02409	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SB48_HM08orf02411	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
SB48_HM08orf02414	COG1286	toxin biosynthetic process
SB48_HM08orf02419	COG1796	DNA polymerase
SB48_HM08orf02419	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SB48_HM08orf02421	COG1193	negative regulation of DNA recombination
SB48_HM08orf02423	COG0318	PFAM AMP-dependent synthetase and ligase
SB48_HM08orf02427	COG1309	transcriptional regulator
SB48_HM08orf02428	COG1024	Enoyl-CoA hydratase
SB48_HM08orf02430	COG2086	electron transfer activity
SB48_HM08orf02431	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SB48_HM08orf02434	COG3118	belongs to the thioredoxin family
SB48_HM08orf02435	COG0322	excinuclease ABC activity
SB48_HM08orf02440	COG1719	4-vinyl reductase, 4VR
SB48_HM08orf02445	COG2009	succinate dehydrogenase
SB48_HM08orf02446	COG1053	succinate dehydrogenase
SB48_HM08orf02448	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SB48_HM08orf02449	COG0824	Thioesterase
SB48_HM08orf02450	COG2197	response regulator
SB48_HM08orf02463	COG1846	Transcriptional regulator
SB48_HM08orf02467	COG5577	PFAM Coat F domain
SB48_HM08orf02468	COG1063	alcohol dehydrogenase
SB48_HM08orf02469	COG5577	PFAM Coat F domain
SB48_HM08orf02472	COG5401	PFAM Sporulation and spore germination
SB48_HM08orf02474	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SB48_HM08orf02476	COG0622	Phosphoesterase
SB48_HM08orf02490	COG0457	Tetratricopeptide repeat
SB48_HM08orf02490	COG1477	protein flavinylation
SB48_HM08orf02492	COG0544	peptidyl-prolyl cis-trans isomerase activity
SB48_HM08orf02497	COG0470	DNA polymerase III
SB48_HM08orf02497	COG1067	ATP-dependent peptidase activity
SB48_HM08orf02498	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SB48_HM08orf02500	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SB48_HM08orf02507	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SB48_HM08orf02508	COG0181	hydroxymethylbilane synthase activity
SB48_HM08orf02512	COG0113	porphobilinogen synthase activity
SB48_HM08orf02514	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SB48_HM08orf02518	COG1388	LysM domain
SB48_HM08orf02518	COG1388	LysM domain
SB48_HM08orf02519	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SB48_HM08orf02527	COG0525	valine-tRNA ligase activity
SB48_HM08orf02529	COG0285	dihydrofolate synthase activity
SB48_HM08orf02542	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SB48_HM08orf02545	COG1459	type II secretion system
SB48_HM08orf02553	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SB48_HM08orf02560	COG2003	Belongs to the UPF0758 family
SB48_HM08orf02561	COG1077	Cell shape determining protein MreB Mrl
SB48_HM08orf02562	COG1792	Involved in formation and maintenance of cell shape
SB48_HM08orf02568	COG0850	regulation of cytokinetic process
SB48_HM08orf02569	COG2894	cell division
SB48_HM08orf02573	COG1994	Peptidase M50
SB48_HM08orf02575	COG1530	ribonuclease E activity
SB48_HM08orf02578	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SB48_HM08orf02580	COG2868	ribosomal protein
SB48_HM08orf02581	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SB48_HM08orf02582	COG3290	protein histidine kinase activity
SB48_HM08orf02583	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SB48_HM08orf02585	COG4492	Belongs to the UPF0735 family
SB48_HM08orf02586	COG0077	Prephenate dehydratase
SB48_HM08orf02587	COG1827	regulation of RNA biosynthetic process
SB48_HM08orf02589	COG1388	LysM domain
SB48_HM08orf02594	COG0217	transcriptional regulatory protein
SB48_HM08orf02601	COG0632	four-way junction helicase activity
SB48_HM08orf02604	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SB48_HM08orf02606	COG0343	queuine tRNA-ribosyltransferase activity
SB48_HM08orf02608	COG1862	Preprotein translocase
SB48_HM08orf02611	COG2323	membrane
SB48_HM08orf02613	COG2244	polysaccharide biosynthetic process
SB48_HM08orf02619	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SB48_HM08orf02619	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SB48_HM08orf02622	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SB48_HM08orf02622	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SB48_HM08orf02623	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SB48_HM08orf02627	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SB48_HM08orf02628	COG1490	D-aminoacyl-tRNA deacylase activity
SB48_HM08orf02629	COG1846	Transcriptional regulator
SB48_HM08orf02630	COG1566	PFAM secretion protein HlyD family protein
SB48_HM08orf02632	COG2814	Major facilitator Superfamily
SB48_HM08orf02633	COG4991	sh3 domain protein
SB48_HM08orf02633	COG3103	Sh3 type 3 domain protein
SB48_HM08orf02633	COG0860	N-Acetylmuramoyl-L-alanine amidase
SB48_HM08orf02640	COG0124	histidyl-tRNA synthetase
SB48_HM08orf02642	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SB48_HM08orf02644	COG0385	Bile acid
SB48_HM08orf02647	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SB48_HM08orf02651	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SB48_HM08orf02654	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_HM08orf02658	COG1959	2 iron, 2 sulfur cluster binding
SB48_HM08orf02660	COG1104	cysteine desulfurase activity
SB48_HM08orf02661	COG0482	sulfurtransferase activity
SB48_HM08orf02666	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SB48_HM08orf02681	COG0628	permease
SB48_HM08orf02684	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SB48_HM08orf02685	COG4472	Bacterial protein of unknown function (DUF965)
SB48_HM08orf02686	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SB48_HM08orf02687	COG3906	Belongs to the UPF0473 family
SB48_HM08orf02689	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SB48_HM08orf02691	COG0572	uridine kinase
SB48_HM08orf02693	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SB48_HM08orf02703	COG0450	alkyl hydroperoxide reductase
SB48_HM08orf02704	COG3634	alkyl hydroperoxide reductase activity
SB48_HM08orf02709	COG1183	phosphatidylcholine synthase activity
SB48_HM08orf02728	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SB48_HM08orf02731	COG0071	Belongs to the small heat shock protein (HSP20) family
SB48_HM08orf02732	COG2132	Multicopper oxidase
SB48_HM08orf02733	COG3835	regulator
SB48_HM08orf02736	COG0277	FAD linked oxidase domain protein
SB48_HM08orf02737	COG0247	lactate metabolic process
SB48_HM08orf02742	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SB48_HM08orf02743	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SB48_HM08orf02745	COG1534	Rna-binding protein
SB48_HM08orf02746	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SB48_HM08orf02748	COG1713	HD superfamily hydrolase involved in NAD metabolism
SB48_HM08orf02749	COG0799	negative regulation of ribosome biogenesis
SB48_HM08orf02750	COG2226	methyltransferase
SB48_HM08orf02752	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SB48_HM08orf02755	COG1596	polysaccharide export
SB48_HM08orf02755	COG1555	photosystem II stabilization
SB48_HM08orf02757	COG2131	deaminase
SB48_HM08orf02758	COG2333	competence protein COMEC
SB48_HM08orf02758	COG0658	competence protein
SB48_HM08orf02762	COG1466	dna polymerase III delta subunit
SB48_HM08orf02764	COG0268	Binds directly to 16S ribosomal RNA
SB48_HM08orf02767	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
SB48_HM08orf02769	COG0860	N-Acetylmuramoyl-L-alanine amidase
SB48_HM08orf02770	COG0481	GTPase activity
SB48_HM08orf02772	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SB48_HM08orf02774	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SB48_HM08orf02775	COG0443	Heat shock 70 kDa protein
SB48_HM08orf02779	COG2264	protein methyltransferase activity
SB48_HM08orf02780	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SB48_HM08orf02781	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SB48_HM08orf02784	COG1283	sodium-dependent phosphate transmembrane transporter activity
SB48_HM08orf02788	COG1610	YqeY-like protein
SB48_HM08orf02793	COG1702	phosphate starvation-inducible protein PhoH
SB48_HM08orf02797	COG1480	7TM receptor with intracellular HD hydrolase
SB48_HM08orf02798	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SB48_HM08orf02799	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SB48_HM08orf02805	COG1381	Involved in DNA repair and RecF pathway recombination
SB48_HM08orf02807	COG0517	IMP dehydrogenase activity
SB48_HM08orf02813	COG0358	DNA primase activity
SB48_HM08orf02814	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SB48_HM08orf02819	COG2010	Cytochrome c
SB48_HM08orf02820	COG2384	SAM-dependent methyltransferase
SB48_HM08orf02821	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SB48_HM08orf02825	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SB48_HM08orf02831	COG0513	Belongs to the DEAD box helicase family
SB48_HM08orf02834	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SB48_HM08orf02836	COG0791	NLP P60 protein
SB48_HM08orf02836	COG3883	PFAM NLP P60 protein
SB48_HM08orf02841	COG1121	(ABC) transporter
SB48_HM08orf02842	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SB48_HM08orf02844	COG0735	belongs to the Fur family
SB48_HM08orf02847	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
SB48_HM08orf02848	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SB48_HM08orf02850	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SB48_HM08orf02851	COG0477	Major facilitator Superfamily
SB48_HM08orf02856	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SB48_HM08orf02861	COG0457	Tetratricopeptide repeat
SB48_HM08orf02861	COG0705	Rhomboid family
SB48_HM08orf02864	COG4483	Protein conserved in bacteria
SB48_HM08orf02865	COG1940	carbohydrate kinase activity
SB48_HM08orf02868	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SB48_HM08orf02872	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SB48_HM08orf02873	COG1459	type II secretion system
SB48_HM08orf02876	COG4537	Required for transformation and DNA binding
SB48_HM08orf02883	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SB48_HM08orf02887	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SB48_HM08orf02891	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SB48_HM08orf02893	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SB48_HM08orf02894	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SB48_HM08orf02896	COG0095	Lipoate-protein ligase
SB48_HM08orf02899	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SB48_HM08orf02903	COG0492	ferredoxin-NADP+ reductase activity
SB48_HM08orf02905	COG1024	Enoyl-CoA hydratase
SB48_HM08orf02908	COG1012	belongs to the aldehyde dehydrogenase family
SB48_HM08orf02909	COG1250	3-hydroxyacyl-CoA dehydrogenase
SB48_HM08orf02910	COG0183	Belongs to the thiolase family
SB48_HM08orf02911	COG3327	negative regulation of DNA-templated transcription, initiation
SB48_HM08orf02914	COG1752	Esterase of the alpha-beta hydrolase superfamily
SB48_HM08orf02917	COG3872	metal-dependent enzyme
SB48_HM08orf02924	COG0006	proline dipeptidase activity
SB48_HM08orf02925	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SB48_HM08orf02927	COG3854	ATPases associated with a variety of cellular activities
SB48_HM08orf02941	COG0511	ligase activity, forming carbon-carbon bonds
SB48_HM08orf02942	COG0439	Biotin carboxylase
SB48_HM08orf02943	COG1302	Protein conserved in bacteria
SB48_HM08orf02948	COG1570	exodeoxyribonuclease VII activity
SB48_HM08orf02952	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SB48_HM08orf02954	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SB48_HM08orf02957	COG0497	DNA recombination
SB48_HM08orf02958	COG0750	zinc metalloprotease
SB48_HM08orf02960	COG0745	RESPONSE REGULATOR receiver
SB48_HM08orf02962	COG0584	glycerophosphoryl diester phosphodiesterase
SB48_HM08orf02969	COG3829	transcription factor binding
SB48_HM08orf02969	COG3290	protein histidine kinase activity
SB48_HM08orf02971	COG3290	protein histidine kinase activity
SB48_HM08orf02971	COG3829	transcription factor binding
SB48_HM08orf02974	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SB48_HM08orf02975	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SB48_HM08orf02977	COG0022	dehydrogenase e1 component
SB48_HM08orf02979	COG0508	dehydrogenase complex catalyzes the overall conversion of
SB48_HM08orf02983	COG1105	Belongs to the carbohydrate kinase PfkB family
SB48_HM08orf02989	COG1376	ErfK ybiS ycfS ynhG family protein
SB48_HM08orf02993	COG2195	Cleaves the N-terminal amino acid of tripeptides
SB48_HM08orf02996	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SB48_HM08orf02999	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SB48_HM08orf03004	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SB48_HM08orf03009	COG0300	oxidoreductase activity
SB48_HM08orf03011	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SB48_HM08orf03017	COG3858	chitin binding
SB48_HM08orf03017	COG1388	LysM domain
SB48_HM08orf03019	COG1073	alpha beta
SB48_HM08orf03023	COG3853	Toxic anion resistance protein (TelA)
SB48_HM08orf03025	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
SB48_HM08orf03031	COG0667	Aldo Keto reductase
SB48_HM08orf03035	COG1379	DNA repair
SB48_HM08orf03036	COG1300	Membrane
SB48_HM08orf03039	COG0735	belongs to the Fur family
SB48_HM08orf03042	COG4974	Belongs to the 'phage' integrase family
SB48_HM08orf03045	COG1686	Belongs to the peptidase S11 family
SB48_HM08orf03050	COG1191	sigma factor activity
SB48_HM08orf03058	COG0697	spore germination
SB48_HM08orf03068	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SB48_HM08orf03070	COG1686	Belongs to the peptidase S11 family
SB48_HM08orf03071	COG2715	membrane protein required for spore maturation
SB48_HM08orf03073	COG0700	Nucleoside recognition
SB48_HM08orf03075	COG1187	pseudouridine synthase activity
SB48_HM08orf03077	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SB48_HM08orf03079	COG1333	cytochrome c biogenesis protein
SB48_HM08orf03081	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SB48_HM08orf03084	COG0745	RESPONSE REGULATOR receiver
SB48_HM08orf03086	COG5002	protein histidine kinase activity
SB48_HM08orf03089	COG1196	nuclear chromosome segregation
SB48_HM08orf03089	COG0741	lytic transglycosylase activity
SB48_HM08orf03089	COG0739	heme binding
SB48_HM08orf03091	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SB48_HM08orf03094	COG1141	Ferredoxin
SB48_HM08orf03100	COG0514	ATP-dependent DNA helicase (RecQ)
SB48_HM08orf03102	COG1266	CAAX protease self-immunity
SB48_HM08orf03105	COG3546	catalase activity
SB48_HM08orf03109	COG1408	metallophosphoesterase
SB48_HM08orf03113	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SB48_HM08orf03116	COG0492	ferredoxin-NADP+ reductase activity
SB48_HM08orf03117	COG2339	peptidase activity
SB48_HM08orf03121	COG3773	Cell wall hydrolase
SB48_HM08orf03121	COG3409	Peptidoglycan-binding domain 1 protein
SB48_HM08orf03123	COG2959	enzyme of heme biosynthesis
SB48_HM08orf03125	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
SB48_HM08orf03128	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SB48_HM08orf03131	COG0539	negative regulation of cytoplasmic translation
SB48_HM08orf03137	COG1160	GTP binding
SB48_HM08orf03144	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SB48_HM08orf03146	COG0776	regulation of translation
SB48_HM08orf03150	COG0142	geranyltranstransferase activity
SB48_HM08orf03152	COG2226	methyltransferase
SB48_HM08orf03154	COG0142	geranyltranstransferase activity
SB48_HM08orf03156	COG0105	UTP biosynthetic process
SB48_HM08orf03157	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SB48_HM08orf03158	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SB48_HM08orf03160	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SB48_HM08orf03161	COG4401	Chorismate mutase type I
SB48_HM08orf03162	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SB48_HM08orf03164	COG0287	Prephenate dehydrogenase
SB48_HM08orf03166	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SB48_HM08orf03171	COG0457	Tetratricopeptide repeat
SB48_HM08orf03173	COG5582	Belongs to the UPF0302 family
SB48_HM08orf03176	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SB48_HM08orf03180	COG4347	Protein of unknown function (DUF1405)
SB48_HM08orf03183	COG2738	Putative neutral zinc metallopeptidase
SB48_HM08orf03186	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SB48_HM08orf03188	COG1694	Mazg nucleotide pyrophosphohydrolase
SB48_HM08orf03190	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SB48_HM08orf03193	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SB48_HM08orf03194	COG0438	transferase activity, transferring glycosyl groups
SB48_HM08orf03198	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SB48_HM08orf03199	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SB48_HM08orf03202	COG1199	ATP-dependent helicase activity
SB48_HM08orf03202	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SB48_HM08orf03208	COG0017	Asparaginyl-tRNA synthetase
SB48_HM08orf03210	COG3935	DnaD domain protein
SB48_HM08orf03211	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SB48_HM08orf03215	COG4499	WXG100 protein secretion system (Wss), protein YukC
SB48_HM08orf03215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SB48_HM08orf03217	COG3331	DNA recombination
SB48_HM08orf03226	COG0071	Belongs to the small heat shock protein (HSP20) family
SB48_HM08orf03228	COG1111	helicase
SB48_HM08orf03228	COG1205	dead DEAH box helicase
SB48_HM08orf03231	COG3359	exonuclease
SB48_HM08orf03237	COG4474	Belongs to the UPF0398 family
SB48_HM08orf03243	COG0116	Belongs to the methyltransferase superfamily
SB48_HM08orf03244	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SB48_HM08orf03250	COG2233	PERMEase
SB48_HM08orf03257	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SB48_HM08orf03259	COG0789	Transcriptional regulator
SB48_HM08orf03262	COG0174	glutamine synthetase
SB48_HM08orf03264	COG0582	viral genome integration into host DNA
SB48_HM08orf03269	COG2176	DNA-directed DNA polymerase activity
SB48_HM08orf03275	COG1396	sequence-specific DNA binding
SB48_HM08orf03284	COG0629	single-stranded DNA binding
SB48_HM08orf03293	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
SB48_HM08orf03294	COG0582	viral genome integration into host DNA
SB48_HM08orf03304	COG0740	serine-type endopeptidase activity
SB48_HM08orf03316	COG5280	Phage tail tape measure protein TP901
SB48_HM08orf03316	COG3953	SLT domain
SB48_HM08orf03327	COG1388	LysM domain
SB48_HM08orf03327	COG0791	NLP P60 protein
SB48_HM08orf03331	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SB48_HM08orf03333	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SB48_HM08orf03334	COG4224	UPF0291 protein
SB48_HM08orf03339	COG3763	UPF0154 protein
SB48_HM08orf03342	COG0785	Cytochrome C biogenesis protein
SB48_HM08orf03343	COG2201	protein-glutamate methylesterase activity
SB48_HM08orf03346	COG4846	Membrane protein involved in cytochrome C biogenesis
SB48_HM08orf03352	COG0204	Acyl-transferase
SB48_HM08orf03355	COG2027	D-alanyl-D-alanine carboxypeptidase
SB48_HM08orf03356	COG1619	proteins homologs of microcin C7 resistance protein MccF
SB48_HM08orf03366	COG3546	catalase activity
SB48_HM08orf03369	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SB48_HM08orf03370	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SB48_HM08orf03371	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SB48_HM08orf03373	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SB48_HM08orf03374	COG0505	Belongs to the CarA family
SB48_HM08orf03375	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SB48_HM08orf03377	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SB48_HM08orf03378	COG0137	argininosuccinate synthase activity
SB48_HM08orf03379	COG0165	Argininosuccinate lyase
SB48_HM08orf03381	COG0436	Aminotransferase
SB48_HM08orf03392	COG0789	Transcriptional regulator
SB48_HM08orf03393	COG4990	cell redox homeostasis
SB48_HM08orf03396	COG2404	hydrolase activity, acting on ester bonds
SB48_HM08orf03399	COG1252	NADH dehydrogenase
SB48_HM08orf03405	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SB48_HM08orf03407	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SB48_HM08orf03408	COG0701	Predicted permease
SB48_HM08orf03412	COG0709	Synthesizes selenophosphate from selenide and ATP
SB48_HM08orf03413	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
SB48_HM08orf03416	COG0277	FAD linked oxidase domain protein
SB48_HM08orf03419	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_HM08orf03421	COG2030	dehydratase
SB48_HM08orf03424	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SB48_HM08orf03435	COG1131	(ABC) transporter
SB48_HM08orf03436	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
SB48_HM08orf03439	COG0783	Belongs to the Dps family
SB48_HM08orf03442	COG1914	H( )-stimulated, divalent metal cation uptake system
SB48_HM08orf03445	COG0494	nUDIX hydrolase
SB48_HM08orf03448	COG1247	-acetyltransferase
SB48_HM08orf03459	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SB48_HM08orf03460	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SB48_HM08orf03462	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SB48_HM08orf03463	COG0297	glycogen (starch) synthase activity
SB48_HM08orf03468	COG0708	Exodeoxyribonuclease III
SB48_HM08orf03469	COG3773	Cell wall hydrolase
SB48_HM08orf03470	COG2223	nitrite transmembrane transporter activity
SB48_HM08orf03471	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_HM08orf03474	COG0039	L-malate dehydrogenase activity
SB48_HM08orf03481	COG2322	membrane
SB48_HM08orf03482	COG0561	phosphatase activity
SB48_HM08orf03485	COG2072	flavoprotein involved in K transport
SB48_HM08orf03487	COG2233	PERMEase
SB48_HM08orf03488	COG2508	Transcriptional regulator
SB48_HM08orf03489	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SB48_HM08orf03491	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SB48_HM08orf03497	COG0318	PFAM AMP-dependent synthetase and ligase
SB48_HM08orf03498	COG0183	Belongs to the thiolase family
SB48_HM08orf03502	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SB48_HM08orf03507	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SB48_HM08orf03515	COG1511	domain protein
SB48_HM08orf03515	COG3264	Mechanosensitive ion channel
SB48_HM08orf03516	COG3284	Transcriptional regulator
SB48_HM08orf03517	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SB48_HM08orf03518	COG0508	dehydrogenase complex catalyzes the overall conversion of
SB48_HM08orf03520	COG0022	dehydrogenase e1 component
SB48_HM08orf03521	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SB48_HM08orf03523	COG0697	spore germination
SB48_HM08orf03525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SB48_HM08orf03528	COG0789	Transcriptional regulator
SB48_HM08orf03530	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SB48_HM08orf03532	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SB48_HM08orf03534	COG2045	Belongs to the ComB family
SB48_HM08orf03535	COG1809	phosphosulfolactate synthase activity
SB48_HM08orf03538	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SB48_HM08orf03539	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SB48_HM08orf03542	COG2814	Major facilitator Superfamily
SB48_HM08orf03543	COG1309	transcriptional regulator
SB48_HM08orf03557	COG2258	MOSC domain
SB48_HM08orf03563	COG0351	phosphomethylpyrimidine kinase
SB48_HM08orf03565	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SB48_HM08orf03567	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_HM08orf03569	COG0456	acetyltransferase
SB48_HM08orf03570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SB48_HM08orf03571	COG0456	acetyltransferase
SB48_HM08orf03584	COG2226	methyltransferase
SB48_HM08orf03591	COG0473	3-isopropylmalate dehydrogenase activity
SB48_HM08orf03594	COG0681	Belongs to the peptidase S26 family
SB48_HM08orf03597	COG2070	2-Nitropropane dioxygenase
SB48_HM08orf03609	COG0574	Belongs to the PEP-utilizing enzyme family
SB48_HM08orf03609	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SB48_HM08orf03610	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SB48_HM08orf03617	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SB48_HM08orf03620	COG0187	DNA topoisomerase II activity
SB48_HM08orf03623	COG1832	CoA-binding protein
SB48_HM08orf03626	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SB48_HM08orf03629	COG4841	protein insertion into membrane
SB48_HM08orf03635	COG0824	Thioesterase
SB48_HM08orf03643	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SB48_HM08orf03645	COG2309	aminopeptidase activity
SB48_HM08orf03654	COG0318	PFAM AMP-dependent synthetase and ligase
SB48_HM08orf03655	COG1346	cytolysis
SB48_HM08orf03657	COG1380	Effector of murein hydrolase LrgA
SB48_HM08orf03660	COG1132	(ABC) transporter
SB48_HM08orf03661	COG1132	(ABC) transporter
SB48_HM08orf03667	COG0477	Major facilitator Superfamily
SB48_HM08orf03675	COG1113	amino acid transport
SB48_HM08orf03678	COG5039	Polysaccharide pyruvyl transferase
SB48_HM08orf03679	COG2814	Major facilitator Superfamily
SB48_HM08orf03680	COG0640	Transcriptional regulator
SB48_HM08orf03683	COG3328	transposase activity
SB48_HM08orf03690	COG0745	RESPONSE REGULATOR receiver
SB48_HM08orf03692	COG0642	Histidine kinase
SB48_HM08orf03693	COG1136	(ABC) transporter
SB48_HM08orf03694	COG0577	efflux transmembrane transporter activity
SB48_HM08orf03700	COG3634	alkyl hydroperoxide reductase activity
SB48_HM08orf03701	COG0302	gtp cyclohydrolase
SB48_HM08orf03703	COG1278	Cold shock
SB48_HM08orf03706	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SB48_HM08orf03709	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SB48_HM08orf03710	COG2807	transmembrane transport
SB48_HM08orf03716	COG0569	domain protein
SB48_HM08orf03717	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SB48_HM08orf03720	COG2962	Rard protein
SB48_HM08orf03724	COG2391	methyltransferase activity
SB48_HM08orf03727	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SB48_HM08orf03727	COG0140	phosphoribosyl-ATP diphosphatase activity
SB48_HM08orf03729	COG0107	imidazoleglycerol-phosphate synthase activity
SB48_HM08orf03732	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SB48_HM08orf03734	COG0131	Imidazoleglycerol-phosphate dehydratase
SB48_HM08orf03736	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SB48_HM08orf03739	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SB48_HM08orf03740	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SB48_HM08orf03742	COG0598	Magnesium transport protein CorA
SB48_HM08orf03745	COG1280	lysine exporter protein (LysE YggA)
SB48_HM08orf03746	COG1113	amino acid transport
SB48_HM08orf03751	COG1388	LysM domain
SB48_HM08orf03751	COG3584	3D domain protein
SB48_HM08orf03752	COG0723	plastoquinol--plastocyanin reductase activity
SB48_HM08orf03752	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SB48_HM08orf03753	COG0517	IMP dehydrogenase activity
SB48_HM08orf03753	COG0516	GMP reductase activity
SB48_HM08orf03754	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SB48_HM08orf03759	COG2135	peptidase activity
SB48_HM08orf03772	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SB48_HM08orf03776	COG0706	membrane insertase activity
SB48_HM08orf03778	COG1012	belongs to the aldehyde dehydrogenase family
SB48_HM08orf03779	COG0508	dehydrogenase complex catalyzes the overall conversion of
SB48_HM08orf03781	COG0567	Dehydrogenase, E1 component
SB48_HM08orf03786	COG5002	protein histidine kinase activity
SB48_HM08orf03787	COG0745	RESPONSE REGULATOR receiver
SB48_HM08orf03791	COG2814	Major facilitator Superfamily
SB48_HM08orf03792	COG1331	Highly conserved protein containing a thioredoxin domain
SB48_HM08orf03799	COG1368	sulfuric ester hydrolase activity
SB48_HM08orf03802	COG0671	phosphoesterase, PA-phosphatase related
SB48_HM08orf03805	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SB48_HM08orf03806	COG3285	dna ligase
SB48_HM08orf03806	COG1793	dna ligase
SB48_HM08orf03808	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SB48_HM08orf03814	COG0534	Mate efflux family protein
SB48_HM08orf03818	COG2340	Cysteine-rich secretory protein family
SB48_HM08orf03822	COG1846	Transcriptional regulator
SB48_HM08orf03824	COG3409	Peptidoglycan-binding domain 1 protein
SB48_HM08orf03824	COG0793	Belongs to the peptidase S41A family
SB48_HM08orf03826	COG1876	peptidase activity
SB48_HM08orf03836	COG4479	Belongs to the UPF0346 family
SB48_HM08orf03840	COG0840	transmembrane signaling receptor activity
SB48_HM08orf03843	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SB48_HM08orf03844	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SB48_HM08orf03846	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SB48_HM08orf03846	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SB48_HM08orf03852	COG2755	lipolytic protein G-D-S-L family
SB48_HM08orf03853	COG1272	protein, Hemolysin III
SB48_HM08orf03854	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SB48_HM08orf03855	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SB48_HM08orf03862	COG1413	lyase activity
SB48_HM08orf03864	COG0488	(ABC) transporter
SB48_HM08orf03865	COG1418	mRNA catabolic process
SB48_HM08orf03869	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SB48_HM08orf03871	COG1321	iron dependent repressor
SB48_HM08orf03880	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SB48_HM08orf03881	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SB48_HM08orf03883	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SB48_HM08orf03885	COG0464	growth
SB48_HM08orf03891	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SB48_HM08orf03902	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SB48_HM08orf03904	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SB48_HM08orf03907	COG4550	Control of competence regulator ComK, YlbF/YmcA
SB48_HM08orf03909	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SB48_HM08orf03924	COG0531	amino acid
SB48_HM08orf03930	COG2359	stage V sporulation protein S
SB48_HM08orf03934	COG1692	metallophosphoesterase
SB48_HM08orf03935	COG1418	mRNA catabolic process
SB48_HM08orf03940	COG1546	Belongs to the CinA family
SB48_HM08orf03940	COG1058	Belongs to the CinA family
SB48_HM08orf03941	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SB48_HM08orf03942	COG1426	Protein conserved in bacteria
SB48_HM08orf03948	COG0300	oxidoreductase activity
SB48_HM08orf03949	COG0612	Peptidase, M16
SB48_HM08orf03950	COG0612	Peptidase, M16
SB48_HM08orf03960	COG1674	ftsk spoiiie
SB48_HM08orf03960	COG4980	gas vesicle protein
SB48_HM08orf03962	COG0740	serine-type endopeptidase activity
SB48_HM08orf03964	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SB48_HM08orf03968	COG0527	aspartate kinase activity
SB48_HM08orf03971	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SB48_HM08orf03974	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SB48_HM08orf03975	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SB48_HM08orf03976	COG1873	PFAM PRC-barrel domain
SB48_HM08orf03979	COG0612	Peptidase, M16
SB48_HM08orf03981	COG0726	polysaccharide deacetylase
SB48_HM08orf03983	COG1185	polyribonucleotide nucleotidyltransferase activity
SB48_HM08orf03984	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SB48_HM08orf03986	COG0196	riboflavin kinase activity
SB48_HM08orf03989	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SB48_HM08orf03991	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SB48_HM08orf03992	COG1550	Protein conserved in bacteria
SB48_HM08orf03997	COG1358	cellular component organization or biogenesis
SB48_HM08orf03999	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SB48_HM08orf04001	COG0195	Participates in both transcription termination and antitermination
SB48_HM08orf04002	COG0779	Required for maturation of 30S ribosomal subunits
SB48_HM08orf04004	COG2176	DNA-directed DNA polymerase activity
SB48_HM08orf04008	COG0442	prolyl-tRNA aminoacylation
SB48_HM08orf04011	COG0750	zinc metalloprotease
SB48_HM08orf04015	COG4589	Belongs to the CDS family
SB48_HM08orf04017	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SB48_HM08orf04023	COG0233	cytoplasmic translational termination
SB48_HM08orf04024	COG0528	UMP kinase activity
SB48_HM08orf04026	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SB48_HM08orf04028	COG0052	Belongs to the universal ribosomal protein uS2 family
SB48_HM08orf04033	COG1191	sigma factor activity
SB48_HM08orf04036	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
SB48_HM08orf04037	COG1776	CheC inhibitor of MCP methylation
SB48_HM08orf04038	COG0835	chemotaxis
SB48_HM08orf04041	COG2198	Histidine kinase
SB48_HM08orf04041	COG0643	Histidine kinase
SB48_HM08orf04042	COG2201	protein-glutamate methylesterase activity
SB48_HM08orf04045	COG0455	bacterial-type flagellum organization
SB48_HM08orf04046	COG1419	protein localization to endoplasmic reticulum
SB48_HM08orf04048	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SB48_HM08orf04049	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SB48_HM08orf04051	COG1684	flagellar biosynthetic protein fliR
SB48_HM08orf04052	COG1987	bacterial-type flagellum assembly
SB48_HM08orf04053	COG1338	Plays a role in the flagellum-specific transport system
SB48_HM08orf04055	COG3190	flagellar
SB48_HM08orf04056	COG2201	protein-glutamate methylesterase activity
SB48_HM08orf04058	COG1776	CheC inhibitor of MCP methylation
SB48_HM08orf04058	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SB48_HM08orf04059	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SB48_HM08orf04061	COG1580	Controls the rotational direction of flagella during chemotaxis
SB48_HM08orf04063	COG4786	Flagellar basal body rod
SB48_HM08orf04068	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
SB48_HM08orf04074	COG2882	bacterial-type flagellum organization
SB48_HM08orf04076	COG1157	protein secretion by the type III secretion system
SB48_HM08orf04077	COG1317	bacterial-type flagellum organization
SB48_HM08orf04079	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SB48_HM08orf04082	COG1766	The M ring may be actively involved in energy transduction
SB48_HM08orf04084	COG1677	Flagellar hook-basal body complex protein FliE
SB48_HM08orf04085	COG1558	bacterial-type flagellum-dependent cell motility
SB48_HM08orf04087	COG1815	bacterial-type flagellum-dependent cell motility
SB48_HM08orf04089	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SB48_HM08orf04093	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SB48_HM08orf04095	COG4974	Belongs to the 'phage' integrase family
SB48_HM08orf04105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SB48_HM08orf04106	COG0758	DNA mediated transformation
SB48_HM08orf04108	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SB48_HM08orf04109	COG0045	succinate-CoA ligase (ADP-forming) activity
SB48_HM08orf04111	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SB48_HM08orf04116	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SB48_HM08orf04124	COG0336	Belongs to the RNA methyltransferase TrmD family
SB48_HM08orf04125	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SB48_HM08orf04128	COG1837	Belongs to the UPF0109 family
SB48_HM08orf04130	COG0228	four-way junction DNA binding
SB48_HM08orf04131	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SB48_HM08orf04137	COG0552	protein localization to endoplasmic reticulum
SB48_HM08orf04138	COG1196	nuclear chromosome segregation
SB48_HM08orf04139	COG0571	ribonuclease III activity
SB48_HM08orf04140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SB48_HM08orf04141	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_HM08orf04143	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SB48_HM08orf04144	COG0416	fatty acid biosynthetic process
SB48_HM08orf04145	COG2050	protein possibly involved in aromatic compounds catabolism
SB48_HM08orf04145	COG1349	DNA-binding transcription factor activity
SB48_HM08orf04147	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SB48_HM08orf04149	COG1760	l-serine dehydratase
SB48_HM08orf04151	COG1760	l-serine dehydratase
SB48_HM08orf04154	COG1461	Dihydroxyacetone kinase
SB48_HM08orf04155	COG1302	Protein conserved in bacteria
SB48_HM08orf04159	COG1564	THIamine pyrophosphokinase
SB48_HM08orf04161	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SB48_HM08orf04164	COG0515	serine threonine protein kinase
SB48_HM08orf04164	COG2815	serine threonine protein kinase
SB48_HM08orf04165	COG0631	protein serine/threonine phosphatase activity
SB48_HM08orf04167	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SB48_HM08orf04167	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SB48_HM08orf04169	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SB48_HM08orf04170	COG0242	peptide deformylase activity
SB48_HM08orf04172	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SB48_HM08orf04174	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SB48_HM08orf04177	COG0194	GDP metabolic process
SB48_HM08orf04178	COG2052	Domain of unknown function (DUF370)
SB48_HM08orf04179	COG1561	YicC-like family, N-terminal region
SB48_HM08orf04182	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SB48_HM08orf04186	COG0385	Bile acid
SB48_HM08orf04191	COG0720	synthase
SB48_HM08orf04210	COG0561	phosphatase activity
SB48_HM08orf04211	COG0628	permease
SB48_HM08orf04213	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SB48_HM08orf04215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SB48_HM08orf04219	COG2076	Multidrug Resistance protein
SB48_HM08orf04221	COG1309	transcriptional regulator
SB48_HM08orf04222	COG0477	Major facilitator Superfamily
SB48_HM08orf04223	COG0477	Major facilitator Superfamily
SB48_HM08orf04224	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SB48_HM08orf04228	COG1803	Methylglyoxal synthase
SB48_HM08orf04232	COG0235	Class ii aldolase
SB48_HM08orf04234	COG4806	L-rhamnose isomerase
SB48_HM08orf04236	COG1070	Carbohydrate kinase
SB48_HM08orf04237	COG2207	Transcriptional regulator
SB48_HM08orf04237	COG1917	Cupin 2, conserved barrel domain protein
SB48_HM08orf04249	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SB48_HM08orf04250	COG0284	orotidine-5'-phosphate decarboxylase activity
SB48_HM08orf04251	COG0167	dihydroorotate dehydrogenase activity
SB48_HM08orf04257	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SB48_HM08orf04259	COG0540	Belongs to the ATCase OTCase family
SB48_HM08orf04265	COG0564	pseudouridine synthase activity
SB48_HM08orf04267	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SB48_HM08orf04273	COG3599	regulation of cell shape
SB48_HM08orf04274	COG2302	S4 RNA-binding domain
SB48_HM08orf04275	COG0762	integral membrane protein
SB48_HM08orf04277	COG1799	cell septum assembly
SB48_HM08orf04278	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SB48_HM08orf04280	COG3584	3D domain protein
SB48_HM08orf04280	COG1388	LysM domain
SB48_HM08orf04281	COG1873	PFAM PRC-barrel domain
SB48_HM08orf04282	COG1191	sigma factor activity
SB48_HM08orf04284	COG1191	sigma factor activity
SB48_HM08orf04289	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SB48_HM08orf04292	COG0849	cell division
SB48_HM08orf04296	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SB48_HM08orf04298	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SB48_HM08orf04299	COG0772	Belongs to the SEDS family
SB48_HM08orf04301	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SB48_HM08orf04302	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SB48_HM08orf04309	COG0768	penicillin binding
SB48_HM08orf04313	COG4839	cell division protein FtsL
SB48_HM08orf04314	COG0275	rRNA processing
SB48_HM08orf04316	COG2001	Belongs to the MraZ family
SB48_HM08orf04322	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
SB48_HM08orf04324	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SB48_HM08orf04326	COG0454	-acetyltransferase
SB48_HM08orf04329	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SB48_HM08orf04330	COG1399	metal-binding, possibly nucleic acid-binding protein
SB48_HM08orf04332	COG1323	Belongs to the UPF0348 family
SB48_HM08orf04338	COG3480	Lon protease (S16) C-terminal proteolytic domain
SB48_HM08orf04339	COG1752	Esterase of the alpha-beta hydrolase superfamily
SB48_HM08orf04341	COG3314	Sporulation integral membrane protein YlbJ
SB48_HM08orf04345	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SB48_HM08orf04346	COG0742	ribosomal rna small subunit methyltransferase
SB48_HM08orf04354	COG3679	Belongs to the UPF0342 family
SB48_HM08orf04364	COG2050	protein possibly involved in aromatic compounds catabolism
SB48_HM08orf04366	COG2340	Cysteine-rich secretory protein family
SB48_HM08orf04370	COG3336	cytochrome c oxidase
SB48_HM08orf04371	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SB48_HM08orf04376	COG2010	Cytochrome c
SB48_HM08orf04376	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SB48_HM08orf04377	COG0109	protoheme IX farnesyltransferase activity
SB48_HM08orf04379	COG1612	heme a metabolic process
SB48_HM08orf04380	COG0772	Belongs to the SEDS family
SB48_HM08orf04381	COG4838	Belongs to the UPF0358 family
SB48_HM08orf04383	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SB48_HM08orf04384	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SB48_HM08orf04392	COG0483	inositol monophosphate 1-phosphatase activity
SB48_HM08orf04397	COG4476	Belongs to the UPF0223 family
SB48_HM08orf04400	COG1982	Orn Lys Arg decarboxylase major
SB48_HM08orf04415	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SB48_HM08orf04422	COG1473	amidohydrolase
SB48_HM08orf04423	COG2171	N-acyltransferase activity
SB48_HM08orf04425	COG0583	DNA-binding transcription factor activity
SB48_HM08orf04427	COG0517	IMP dehydrogenase activity
SB48_HM08orf04429	COG4703	Protein of unknown function (DUF1797)
SB48_HM08orf04436	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_HM08orf04445	COG1033	growth of symbiont in host cell
SB48_HM08orf04445	COG2409	Drug exporters of the RND superfamily
SB48_HM08orf04449	COG0835	chemotaxis
SB48_HM08orf04449	COG0784	Response regulator, receiver
SB48_HM08orf04452	COG0436	Aminotransferase
SB48_HM08orf04457	COG2084	Dehydrogenase
SB48_HM08orf04458	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_HM08orf04463	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SB48_HM08orf04469	COG4873	Protein conserved in bacteria
SB48_HM08orf04474	COG3949	Membrane
SB48_HM08orf04477	COG0542	response to heat
SB48_HM08orf04487	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SB48_HM08orf04493	COG5002	protein histidine kinase activity
SB48_HM08orf04504	COG0861	Integral membrane protein TerC family
SB48_HM08orf04510	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SB48_HM08orf04512	COG3852	Histidine kinase
SB48_HM08orf04514	COG0673	inositol 2-dehydrogenase activity
SB48_HM08orf04519	COG0783	Belongs to the Dps family
SB48_HM08orf04523	COG0730	response to heat
SB48_HM08orf04527	COG1959	2 iron, 2 sulfur cluster binding
SB48_HM08orf04536	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_HM08orf04558	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SB48_HM08orf04559	COG1554	hydrolase, family 65, central catalytic
SB48_HM08orf04563	COG1609	Transcriptional regulator
SB48_HM08orf04575	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SB48_HM08orf04577	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SB48_HM08orf04587	COG1522	sequence-specific DNA binding
SB48_HM08orf04588	COG2059	Chromate
SB48_HM08orf04591	COG2059	Chromate
SB48_HM08orf04592	COG3344	reverse transcriptase
SB48_HM08orf04594	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SB48_HM08orf04612	COG3579	cysteine-type endopeptidase activity
SB48_HM08orf04619	COG1668	transmembrane transport
SB48_HM08orf04620	COG4152	abc transporter atp-binding protein
SB48_HM08orf04623	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_HM08orf04626	COG1940	carbohydrate kinase activity
SB48_HM08orf04647	COG2382	esterase
SB48_HM08orf04649	COG2153	protein acetylation
SB48_HM08orf04665	COG3328	transposase activity
SB48_HM08orf04671	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SB48_HM08orf04687	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SB48_HM08orf04688	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SB48_HM08orf04693	COG0564	pseudouridine synthase activity
SB48_HM08orf04694	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SB48_HM08orf04697	COG2357	RelA SpoT domain protein
SB48_HM08orf04702	COG0741	lytic transglycosylase activity
SB48_HM08orf04709	COG3328	transposase activity
SB48_HM08orf04710	COG3328	transposase activity
SB48_HM08orf04723	COG2346	COG2346, Truncated hemoglobins
SB48_HM08orf04732	COG1164	Oligoendopeptidase f
SB48_HM08orf04733	COG4469	Competence protein
SB48_HM08orf04736	COG4862	establishment of competence for transformation
SB48_HM08orf04740	COG1393	Belongs to the ArsC family
SB48_HM08orf04742	COG4608	Belongs to the ABC transporter superfamily
SB48_HM08orf04743	COG0444	Belongs to the ABC transporter superfamily
SB48_HM08orf04744	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SB48_HM08orf04745	COG0601	transmembrane transport
SB48_HM08orf04746	COG4166	transmembrane transport
SB48_HM08orf04752	COG0180	Tryptophanyl-tRNA synthetase
SB48_HM08orf04756	COG0747	negative chemotaxis
SB48_HM08orf04760	COG0601	transmembrane transport
SB48_HM08orf04761	COG4608	Belongs to the ABC transporter superfamily
SB48_HM08orf04769	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SB48_HM08orf04772	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SB48_HM08orf04786	COG2151	metal-sulfur cluster biosynthetic enzyme
SB48_HM08orf04788	COG0561	phosphatase activity
SB48_HM08orf04797	COG1307	EDD domain protein, DegV family
SB48_HM08orf04799	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_HM08orf04804	COG0179	Fumarylacetoacetate (FAA) hydrolase
SB48_HM08orf04806	COG2311	Membrane
SB48_HM08orf04818	COG1074	ATP-dependent DNA helicase activity
SB48_HM08orf04820	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SB48_HM08orf04831	COG0501	Belongs to the peptidase M48B family
SB48_HM08orf04833	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
SB48_HM08orf04836	COG0318	PFAM AMP-dependent synthetase and ligase
SB48_HM08orf04838	COG0095	Lipoate-protein ligase
SB48_HM08orf04843	COG1999	signal sequence binding
SB48_HM08orf04845	COG1012	belongs to the aldehyde dehydrogenase family
SB48_HM08orf04848	COG0697	spore germination
SB48_HM08orf04850	COG2814	Major facilitator Superfamily
SB48_HM08orf04852	COG3254	rhamnose metabolic process
SB48_HM08orf04854	COG1349	DNA-binding transcription factor activity
SB48_HM08orf04855	COG1263	PTS System
SB48_HM08orf04855	COG2190	(PTS) system
SB48_HM08orf04855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB48_HM08orf04855	COG2190	(PTS) system
SB48_HM08orf04855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB48_HM08orf04855	COG1263	PTS System
SB48_HM08orf04856	COG1511	domain protein
SB48_HM08orf04857	COG1309	transcriptional regulator
SB48_HM08orf04864	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SB48_HM08orf04868	COG2329	Antibiotic biosynthesis monooxygenase
SB48_HM08orf04871	COG3069	C4-dicarboxylate transmembrane transporter activity
SB48_HM08orf04873	COG1473	amidohydrolase
SB48_HM08orf04878	COG4473	ABC transporter
SB48_HM08orf04879	COG1131	(ABC) transporter
SB48_HM08orf04881	COG0537	adenosine 5'-monophosphoramidase activity
SB48_HM08orf04889	COG1846	Transcriptional regulator
SB48_HM08orf04895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SB48_HM08orf04898	COG3481	metal-dependent phosphohydrolase, HD sub domain
SB48_HM08orf04899	COG4717	serine-type aminopeptidase activity
SB48_HM08orf04901	COG0420	3'-5' exonuclease activity
SB48_HM08orf04902	COG3689	TIGRFAM TIGR03943 family protein
SB48_HM08orf04904	COG0701	Predicted permease
SB48_HM08orf04907	COG0861	Integral membrane protein TerC family
SB48_HM08orf04911	COG1024	Enoyl-CoA hydratase
SB48_HM08orf04912	COG0561	phosphatase activity
SB48_HM08orf04916	COG4399	Belongs to the UPF0754 family
SB48_HM08orf04920	COG0189	ligase activity
SB48_HM08orf04921	COG0189	ligase activity
SB48_HM08orf04924	COG2508	Transcriptional regulator
SB48_HM08orf04926	COG3842	ATPase activity
SB48_HM08orf04940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SB48_HM08orf04944	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SB48_HM08orf04947	COG1660	Displays ATPase and GTPase activities
SB48_HM08orf04948	COG1051	belongs to the nudix hydrolase family
SB48_HM08orf04954	COG0492	ferredoxin-NADP+ reductase activity
SB48_HM08orf04957	COG0457	Tetratricopeptide repeat
SB48_HM08orf04959	COG0110	maltose O-acetyltransferase activity
SB48_HM08orf04961	COG0546	phosphoglycolate phosphatase activity
SB48_HM08orf04966	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SB48_HM08orf04968	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SB48_HM08orf04972	COG3595	metallopeptidase activity
SB48_HM08orf04976	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SB48_HM08orf04976	COG0463	Glycosyl transferase, family 2
SB48_HM08orf04978	COG1682	transport, permease protein
SB48_HM08orf04980	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SB48_HM08orf04986	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SB48_HM08orf04990	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SB48_HM08orf04992	COG0556	nucleotide-excision repair
SB48_HM08orf05011	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SB48_HM08orf05013	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SB48_HM08orf05016	COG0581	inorganic phosphate transmembrane transporter activity
SB48_HM08orf05017	COG0573	inorganic phosphate transmembrane transporter activity
SB48_HM08orf05025	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SB48_HM08orf05034	COG5002	protein histidine kinase activity
SB48_HM08orf05035	COG0745	RESPONSE REGULATOR receiver
SB48_HM08orf05042	COG4607	ABC-type enterochelin transport system periplasmic component
SB48_HM08orf05043	COG4604	ABC transporter, ATP-binding protein
SB48_HM08orf05044	COG4605	iron ion homeostasis
SB48_HM08orf05045	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SB48_HM08orf05050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SB48_HM08orf05051	COG3328	transposase activity
SB48_HM08orf05054	COG3409	Peptidoglycan-binding domain 1 protein
SB48_HM08orf05054	COG0793	Belongs to the peptidase S41A family
SB48_HM08orf05056	COG0460	homoserine dehydrogenase
SB48_HM08orf05062	COG0739	heme binding
SB48_HM08orf05063	COG2177	Part of the ABC transporter FtsEX involved in
SB48_HM08orf05065	COG2884	Cell division ATP-binding protein ftsE
SB48_HM08orf05068	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SB48_HM08orf05070	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SB48_HM08orf05071	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SB48_HM08orf05074	COG0653	protein targeting
SB48_HM08orf05085	COG1516	flagellar protein fliS
SB48_HM08orf05086	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
SB48_HM08orf05088	COG1334	flagellar protein FlaG
SB48_HM08orf05096	COG2094	Belongs to the DNA glycosylase MPG family
SB48_HM08orf05102	COG1067	ATP-dependent peptidase activity
SB48_HM08orf05106	COG1113	amino acid transport
SB48_HM08orf05111	COG1113	amino acid transport
SB48_HM08orf05112	COG2271	Major facilitator Superfamily
SB48_HM08orf05115	COG0647	UMP catabolic process
SB48_HM08orf05116	COG1285	pathogenesis
SB48_HM08orf05118	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
SB48_HM08orf05122	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
SB48_HM08orf05125	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SB48_HM08orf05127	COG4786	Flagellar basal body rod
SB48_HM08orf05127	COG1256	bacterial-type flagellum assembly
SB48_HM08orf05131	COG2747	anti-sigma28 factor FlgM
SB48_HM08orf05134	COG1040	competence protein
SB48_HM08orf05138	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SB48_HM08orf05141	COG1307	EDD domain protein, DegV family
SB48_HM08orf05143	COG0531	amino acid
SB48_HM08orf05148	COG2197	response regulator
SB48_HM08orf05150	COG1739	Uncharacterized protein family UPF0029
SB48_HM08orf05153	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SB48_HM08orf05157	COG0768	penicillin binding
SB48_HM08orf05161	COG0791	NLP P60 protein
SB48_HM08orf05161	COG1388	LysM domain
SB48_HM08orf05166	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SB48_HM08orf05168	COG0477	Major facilitator Superfamily
SB48_HM08orf05175	COG1482	cell wall glycoprotein biosynthetic process
SB48_HM08orf05184	COG0346	lactoylglutathione lyase activity
SB48_HM08orf05185	COG2996	Protein conserved in bacteria
SB48_HM08orf05195	COG1609	Transcriptional regulator
SB48_HM08orf05200	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SB48_HM08orf05202	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SB48_HM08orf05208	COG1960	acyl-CoA dehydrogenase activity
SB48_HM08orf05210	COG1960	acyl-CoA dehydrogenase activity
SB48_HM08orf05213	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SB48_HM08orf05215	COG1033	growth of symbiont in host cell
SB48_HM08orf05215	COG2409	Drug exporters of the RND superfamily
SB48_HM08orf05219	COG2814	Major facilitator Superfamily
SB48_HM08orf05220	COG1113	amino acid transport
SB48_HM08orf05221	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SB48_HM08orf05242	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SB48_HM08orf05249	COG2226	methyltransferase
SB48_HM08orf05252	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SB48_HM08orf05254	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SB48_HM08orf05257	COG0436	Aminotransferase
SB48_HM08orf05258	COG0789	Transcriptional regulator
SB48_HM08orf05263	COG1664	Polymer-forming cytoskeletal
SB48_HM08orf05268	COG0534	Mate efflux family protein
SB48_HM08orf05269	COG1250	3-hydroxyacyl-CoA dehydrogenase
SB48_HM08orf05270	COG4717	serine-type aminopeptidase activity
SB48_HM08orf05271	COG0420	3'-5' exonuclease activity
SB48_HM08orf05273	COG0431	NADPH-dependent FMN reductase
SB48_HM08orf05277	COG0656	L-ascorbic acid biosynthetic process
SB48_HM08orf05282	COG0656	L-ascorbic acid biosynthetic process
SB48_HM08orf05293	COG0561	phosphatase activity
SB48_HM08orf05296	COG1609	Transcriptional regulator
SB48_HM08orf05303	COG1063	alcohol dehydrogenase
SB48_HM08orf05306	COG0457	Tetratricopeptide repeat
SB48_HM08orf05309	COG0535	radical SAM domain protein
SB48_HM08orf05316	COG0589	response to stress
SB48_HM08orf05317	COG2244	polysaccharide biosynthetic process
SB48_HM08orf05318	COG2746	aminoglycoside 3-N-acetyltransferase activity
SB48_HM08orf05319	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_HM08orf05321	COG1960	acyl-CoA dehydrogenase activity
SB48_HM08orf05322	COG0318	PFAM AMP-dependent synthetase and ligase
SB48_HM08orf05328	COG1268	BioY protein
SB48_HM08orf05332	COG0024	Methionine aminopeptidase
SB48_HM08orf05334	COG0791	NLP P60 protein
SB48_HM08orf05334	COG1388	LysM domain
SB48_HM08orf05344	COG1012	belongs to the aldehyde dehydrogenase family
SB48_HM08orf05344	COG1454	alcohol dehydrogenase
SB48_HM08orf05351	COG4145	pantothenate transmembrane transporter activity
SB48_HM08orf05358	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SB48_HM08orf05360	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SB48_HM08orf05365	COG0010	Belongs to the arginase family
SB48_HM08orf05367	COG0460	homoserine dehydrogenase
SB48_HM08orf05368	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SB48_HM08orf05369	COG0083	homoserine kinase activity
SB48_HM08orf05371	COG1116	anion transmembrane transporter activity
SB48_HM08orf05373	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SB48_HM08orf05375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SB48_HM08orf05377	COG0154	amidase activity
SB48_HM08orf05380	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SB48_HM08orf05381	COG2079	MmgE PrpD family protein
SB48_HM08orf05390	COG3716	PTS system mannose fructose sorbose family IID component
SB48_HM08orf05391	COG3715	PTS system
SB48_HM08orf05393	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB48_HM08orf05393	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
SB48_HM08orf05396	COG3933	PFAM sigma-54 factor interaction domain-containing protein
SB48_HM08orf05396	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
SB48_HM08orf05402	COG2706	6-phosphogluconolactonase activity
SB48_HM08orf05406	COG0011	TIGRFAM Protein of
SB48_HM08orf05411	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SB48_HM08orf05413	COG1388	LysM domain
SB48_HM08orf05413	COG3584	3D domain protein
SB48_HM08orf05417	COG0039	L-malate dehydrogenase activity
SB48_HM08orf05421	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SB48_HM08orf05423	COG3328	transposase activity
SB48_HM08orf05425	COG0577	efflux transmembrane transporter activity
SB48_HM08orf05425	COG1136	(ABC) transporter
SB48_HM08orf05426	COG1316	TRANSCRIPTIONal
SB48_HM08orf05427	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SB48_HM08orf05430	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SB48_HM08orf05432	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SB48_HM08orf05435	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_HM08orf05450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SB48_HM08orf05451	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SB48_HM08orf05452	COG0604	alcohol dehydrogenase
SB48_HM08orf05459	COG2207	Transcriptional regulator
SB48_HM08orf05460	COG1653	transport
SB48_HM08orf05469	COG0626	cystathionine gamma-synthase activity
SB48_HM08orf05470	COG0626	cystathionine gamma-synthase activity
SB48_HM08orf05474	COG1131	(ABC) transporter
SB48_HM08orf05477	COG2877	3-deoxy-8-phosphooctulonate synthase activity
SB48_HM08orf05480	COG3711	transcriptional antiterminator
SB48_HM08orf05480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SB48_HM08orf05481	COG2723	6-phospho-beta-galactosidase activity
SB48_HM08orf05482	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SB48_HM08orf05482	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SB48_HM08orf05488	COG1447	Phosphotransferase system cellobiose-specific component IIA
SB48_HM08orf05520	COG2186	Transcriptional regulator
SB48_HM08orf05521	COG1620	l-lactate permease
SB48_HM08orf05523	COG0531	amino acid
SB48_HM08orf05528	COG2972	Histidine kinase
SB48_HM08orf05540	COG1363	Peptidase, m42
SB48_HM08orf05546	COG1309	transcriptional regulator
SB48_HM08orf05548	COG0318	PFAM AMP-dependent synthetase and ligase
SB48_HM08orf05555	COG1501	Belongs to the glycosyl hydrolase 31 family
SB48_HM08orf05558	COG3829	transcription factor binding
SB48_HM08orf05558	COG3290	protein histidine kinase activity
SB48_HM08orf05563	COG1012	belongs to the aldehyde dehydrogenase family
SB48_HM08orf05565	COG2610	gluconate transmembrane transporter activity
SB48_HM08orf05567	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_HM08orf05580	COG2116	formate transmembrane transporter activity
SB48_HM08orf05584	COG1104	cysteine desulfurase activity
SB48_HM08orf05585	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SB48_HM08orf05586	COG0157	Belongs to the NadC ModD family
SB48_HM08orf05589	COG2115	Belongs to the xylose isomerase family
SB48_HM08orf05591	COG1070	Carbohydrate kinase
SB48_HM08orf05592	COG2814	Major facilitator Superfamily
SB48_HM08orf05594	COG0371	Dehydrogenase
SB48_HM08orf05602	COG0606	chelatase, subunit chli
SB48_HM08orf05605	COG2272	Belongs to the type-B carboxylesterase lipase family
SB48_HM08orf05609	COG3425	synthase
SB48_HM08orf05611	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SB48_HM08orf05615	COG4297	protein containing double-stranded beta helix domain
SB48_HM08orf05624	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_HM08orf05626	COG0110	maltose O-acetyltransferase activity
SB48_HM08orf05628	COG1510	regulation of RNA biosynthetic process
SB48_HM08orf05630	COG0517	IMP dehydrogenase activity
SB48_HM08orf05630	COG1125	glycine betaine transport
SB48_HM08orf05632	COG1174	glycine betaine transport
SB48_HM08orf05633	COG1732	Glycine betaine
SB48_HM08orf05634	COG1174	glycine betaine transport
SB48_HM08orf05638	COG1609	Transcriptional regulator
SB48_HM08orf05640	COG2814	Major facilitator Superfamily
SB48_HM08orf05642	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SB48_HM08orf05648	COG1113	amino acid transport
SB48_HM08orf05651	COG2190	(PTS) system
SB48_HM08orf05651	COG2211	Major facilitator Superfamily
SB48_HM08orf05652	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SB48_HM08orf05655	COG1447	Phosphotransferase system cellobiose-specific component IIA
SB48_HM08orf05657	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SB48_HM08orf05659	COG3711	transcriptional antiterminator
SB48_HM08orf05659	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SB48_HM08orf05663	COG2130	NADP-dependent
SB48_HM08orf05667	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SB48_HM08orf05677	COG4989	oxidoreductase activity
SB48_HM08orf05680	COG1316	TRANSCRIPTIONal
SB48_HM08orf05682	COG0531	amino acid
SB48_HM08orf05686	COG3867	Arabinogalactan endo-beta-1,4-galactanase
SB48_HM08orf05688	COG0658	competence protein
SB48_HM08orf05688	COG2333	competence protein COMEC
SB48_HM08orf05695	COG2315	Protein conserved in bacteria
SB48_HM08orf05697	COG0145	ligase activity
SB48_HM08orf05699	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SB48_HM08orf05707	COG0235	Class ii aldolase
SB48_HM08orf05709	COG1105	Belongs to the carbohydrate kinase PfkB family
SB48_HM08orf05712	COG3775	system Galactitol-specific IIC component
SB48_HM08orf05713	COG3414	Phosphotransferase system galactitol-specific IIB component
SB48_HM08orf05718	COG3716	PTS system mannose fructose sorbose family IID component
SB48_HM08orf05719	COG3715	PTS system
SB48_HM08orf05720	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
SB48_HM08orf05720	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB48_HM08orf05722	COG3933	PFAM sigma-54 factor interaction domain-containing protein
SB48_HM08orf05722	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
SB48_HM08orf05724	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SB48_HM08orf05726	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
SB48_HM08orf05728	COG1396	sequence-specific DNA binding
SB48_HM08orf05731	COG2188	Transcriptional regulator
SB48_HM08orf05733	COG0363	glucosamine-6-phosphate deaminase activity
SB48_HM08orf05737	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB48_HM08orf05738	COG3715	PTS system
SB48_HM08orf05739	COG3716	PTS system mannose fructose sorbose family IID component
SB48_HM08orf05754	COG2226	methyltransferase
SB48_HM08orf05755	COG5504	Zn-dependent protease
SB48_HM08orf05762	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SB48_HM08orf05767	COG4193	domain, Protein
SB48_HM08orf05780	COG1063	alcohol dehydrogenase
SB48_HM08orf05784	COG1940	carbohydrate kinase activity
SB48_HM08orf05787	COG1070	Carbohydrate kinase
SB48_HM08orf05796	COG1070	Carbohydrate kinase
SB48_HM08orf05798	COG2115	Belongs to the xylose isomerase family
SB48_HM08orf05801	COG1501	Belongs to the glycosyl hydrolase 31 family
SB48_HM08orf05808	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SB48_HM08orf05809	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SB48_HM08orf05809	COG0662	Cupin 2, conserved barrel domain protein
SB48_HM08orf05816	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SB48_HM08orf05817	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SB48_HM08orf05818	COG4464	protein tyrosine phosphatase activity
SB48_HM08orf05819	COG0489	protein tyrosine kinase activity
SB48_HM08orf05820	COG3944	biosynthesis protein
SB48_HM08orf05834	COG1410	methionine synthase
SB48_HM08orf05834	COG0646	methionine synthase
SB48_HM08orf05835	COG0646	methionine synthase
SB48_HM08orf05835	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SB48_HM08orf05842	COG1316	TRANSCRIPTIONal
SB48_HM08orf05845	COG0586	Pfam SNARE associated Golgi protein
SB48_HM08orf05846	COG0586	Pfam SNARE associated Golgi protein
SB48_HM08orf05852	COG1733	regulation of RNA biosynthetic process
SB48_HM08orf05857	COG0765	amino acid transport
SB48_HM08orf05858	COG0765	amino acid transport
SB48_HM08orf05860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SB48_HM08orf05867	COG0628	permease
SB48_HM08orf05872	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SB48_HM08orf05877	COG0531	amino acid
SB48_HM08orf05882	COG0423	glycine-tRNA ligase activity
SB48_HM08orf05895	COG1902	pentaerythritol trinitrate reductase activity
SB48_HM08orf05909	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SB48_HM08orf05910	COG1301	dicarboxylic acid transport
SB48_HM08orf05913	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SB48_HM08orf05914	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SB48_HM08orf05915	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SB48_HM08orf05917	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
SB48_HM08orf05921	COG3973	AAA domain
SB48_HM08orf05923	COG0463	Glycosyl transferase, family 2
SB48_HM08orf05925	COG2851	Citrate transporter
SB48_HM08orf05927	COG4565	transcriptional regulatory protein
SB48_HM08orf05929	COG3290	protein histidine kinase activity
SB48_HM08orf05932	COG0004	ammonium transporteR
SB48_HM08orf05935	COG1979	alcohol dehydrogenase
SB48_HM08orf05938	COG0531	amino acid
SB48_HM08orf05944	COG1953	Uracil, thiamine, allantoin
SB48_HM08orf05947	COG1454	alcohol dehydrogenase
SB48_HM08orf05949	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SB48_HM08orf05952	COG0247	lactate metabolic process
SB48_HM08orf05953	COG1139	Iron-sulfur cluster binding protein
SB48_HM08orf05957	COG1556	Lactate utilization protein
SB48_HM08orf05958	COG0531	amino acid
SB48_HM08orf05960	COG3328	transposase activity
SB48_HM08orf05967	COG3328	transposase activity
SB48_HM08orf05977	COG3328	transposase activity
SB48_HM08orf05980	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SB48_HM08orf05982	COG1176	ABC-type spermidine putrescine transport system, permease component I
SB48_HM08orf05983	COG3842	ATPase activity
SB48_HM08orf05986	COG0833	amino acid
SB48_HM08orf05987	COG3104	oligopeptide transport
SB48_HM08orf05989	COG1113	amino acid transport
SB48_HM08orf05993	COG0667	Aldo Keto reductase
SB48_HM08orf05995	COG5577	PFAM Coat F domain
SB48_HM08orf06000	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SB48_HM08orf06004	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SB48_HM08orf06007	COG1609	Transcriptional regulator
SB48_HM08orf06011	COG2848	UPF0210 protein
SB48_HM08orf06014	COG3830	Belongs to the UPF0237 family
SB48_HM08orf06020	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SB48_HM08orf06026	COG0246	Mannitol dehydrogenase
SB48_HM08orf06028	COG3711	transcriptional antiterminator
SB48_HM08orf06029	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SB48_HM08orf06029	COG2213	PTS system mannitol-specific
SB48_HM08orf06034	COG0702	epimerase
SB48_HM08orf06047	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SB48_HM08orf06055	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SB48_HM08orf06061	COG0697	spore germination
SB48_HM08orf06067	COG0745	RESPONSE REGULATOR receiver
SB48_HM08orf06067	COG3706	GGDEF domain
SB48_HM08orf06072	COG0318	PFAM AMP-dependent synthetase and ligase
SB48_HM08orf06074	COG0371	Dehydrogenase
SB48_HM08orf06077	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SB48_HM08orf06087	COG0175	sulfate reduction
SB48_HM08orf06088	COG5434	Belongs to the glycosyl hydrolase 28 family
SB48_HM08orf06099	COG1012	belongs to the aldehyde dehydrogenase family
SB48_HM08orf06106	COG1309	transcriptional regulator
SB48_HM08orf06109	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_HM08orf06113	COG1366	Belongs to the anti-sigma-factor antagonist family
SB48_HM08orf06114	COG0217	transcriptional regulatory protein
SB48_HM08orf06126	COG1120	ATPase activity
SB48_HM08orf06129	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SB48_HM08orf06130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SB48_HM08orf06131	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SB48_HM08orf06134	COG2076	Multidrug Resistance protein
SB48_HM08orf06135	COG2076	Multidrug Resistance protein
SB48_HM08orf06148	COG0463	Glycosyl transferase, family 2
SB48_HM08orf06150	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SB48_HM08orf06152	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SB48_HM08orf06154	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SB48_HM08orf06157	COG3328	transposase activity
SB48_HM08orf06159	COG2217	Heavy metal translocating P-type atpase
SB48_HM08orf06162	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SB48_HM08orf06164	COG5002	protein histidine kinase activity
SB48_HM08orf06169	COG0716	FMN binding
SB48_HM08orf06172	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SB48_HM08orf06179	COG1070	Carbohydrate kinase
SB48_HM08orf06185	COG2188	Transcriptional regulator
SB48_HM08orf06187	COG0366	Alpha amylase catalytic
SB48_HM08orf06189	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SB48_HM08orf06189	COG1263	PTS System
SB48_HM08orf06190	COG2190	(PTS) system
SB48_HM08orf06193	COG1174	glycine betaine transport
SB48_HM08orf06194	COG1125	glycine betaine transport
SB48_HM08orf06194	COG0517	IMP dehydrogenase activity
SB48_HM08orf06197	COG3328	transposase activity
SB48_HM08orf06207	COG0183	Belongs to the thiolase family
SB48_HM08orf06216	COG0477	Major facilitator Superfamily
SB48_HM08orf06216	COG2814	Major facilitator Superfamily
SB48_HM08orf06225	COG0519	Catalyzes the synthesis of GMP from XMP
SB48_HM08orf06231	COG2814	Major facilitator Superfamily
SB48_HM08orf06234	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SB48_HM08orf06253	COG0840	transmembrane signaling receptor activity
SB48_HM08orf06256	COG1695	Transcriptional regulator
SB48_HM08orf06260	COG0840	transmembrane signaling receptor activity
SB48_HM08orf06261	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SB48_HM08orf06263	COG0583	DNA-binding transcription factor activity
SB48_HM08orf06264	COG2814	Major facilitator Superfamily
SB48_HM08orf06287	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SB48_HM08orf06292	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SB48_HM08orf06294	COG4856	YbbR-like protein
SB48_HM08orf06295	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SB48_HM08orf06296	COG5662	AntiSigma factor
SB48_HM08orf06297	COG1595	DNA-templated transcription, initiation
SB48_HM08orf06302	COG3942	CHAP domain
SB48_HM08orf06302	COG1388	LysM domain
SB48_HM08orf06344	COG0305	Participates in initiation and elongation during chromosome replication
SB48_HM08orf06345	COG3935	DnaD domain protein
SB48_HM08orf06347	COG3723	Recombinational DNA repair protein, rece pathway
SB48_HM08orf06348	COG5377	YqaJ viral recombinase family
SB48_HM08orf06364	COG1525	nuclease
SB48_HM08orf06367	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SB48_HM08orf06372	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SB48_HM08orf06372	COG2010	Cytochrome c
SB48_HM08orf06373	COG0109	protoheme IX farnesyltransferase activity
SB48_HM08orf06377	COG1028	Short-chain dehydrogenase reductase Sdr
SB48_HM08orf06379	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SB48_HM08orf06381	COG4988	ABC transporter
SB48_HM08orf06384	COG1294	oxidase, subunit
SB48_HM08orf06385	COG1271	oxidase subunit
SB48_HM08orf06388	COG0726	polysaccharide deacetylase
SB48_HM08orf06393	COG2194	sulfuric ester hydrolase activity
SB48_HM08orf06397	COG0489	protein tyrosine kinase activity
SB48_HM08orf06398	COG0860	N-Acetylmuramoyl-L-alanine amidase
SB48_HM08orf06400	COG0833	amino acid
SB48_HM08orf06402	COG0529	Catalyzes the synthesis of activated sulfate
SB48_HM08orf06403	COG2046	Belongs to the sulfate adenylyltransferase family
SB48_HM08orf06410	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SB48_HM08orf06412	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SB48_HM08orf06416	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SB48_HM08orf06417	COG1122	ATPase activity
SB48_HM08orf06418	COG1122	ATPase activity
SB48_HM08orf06421	COG0203	ribosomal protein L17
SB48_HM08orf06422	COG0202	RNA polymerase activity
SB48_HM08orf06423	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SB48_HM08orf06425	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SB48_HM08orf06426	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SB48_HM08orf06429	COG0563	adenylate kinase activity
SB48_HM08orf06431	COG0201	protein transport
SB48_HM08orf06432	COG0200	Binds to the 23S rRNA
SB48_HM08orf06435	COG1841	ribosomal large subunit assembly
SB48_HM08orf06436	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SB48_HM08orf06438	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SB48_HM08orf06440	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SB48_HM08orf06441	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SB48_HM08orf06443	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SB48_HM08orf06445	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SB48_HM08orf06446	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SB48_HM08orf06447	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SB48_HM08orf06448	COG0255	Belongs to the universal ribosomal protein uL29 family
SB48_HM08orf06449	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SB48_HM08orf06450	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SB48_HM08orf06451	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SB48_HM08orf06452	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SB48_HM08orf06453	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SB48_HM08orf06455	COG0089	rRNA binding
SB48_HM08orf06457	COG0088	Forms part of the polypeptide exit tunnel
SB48_HM08orf06460	COG0051	transcription antitermination factor activity, RNA binding
SB48_HM08orf06463	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SB48_HM08orf06464	COG0049	tRNA binding
SB48_HM08orf06465	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SB48_HM08orf06467	COG1358	cellular component organization or biogenesis
SB48_HM08orf06475	COG2813	Specifically methylates the guanine in position
SB48_HM08orf06478	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SB48_HM08orf06481	COG0081	regulation of translation
SB48_HM08orf06482	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SB48_HM08orf06483	COG0250	Participates in transcription elongation, termination and antitermination
SB48_HM08orf06484	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SB48_HM08orf06485	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SB48_HM08orf06488	COG3688	RNA-binding protein containing a PIN domain
SB48_HM08orf06489	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SB48_HM08orf06491	COG0215	cysteine-tRNA ligase activity
SB48_HM08orf06492	COG1045	serine acetyltransferase
SB48_HM08orf06495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SB48_HM08orf06501	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SB48_HM08orf06503	COG4956	integral membrane protein (PIN domain superfamily)
SB48_HM08orf06506	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SB48_HM08orf06507	COG0542	response to heat
SB48_HM08orf06508	COG3869	Catalyzes the specific phosphorylation of arginine residues in
SB48_HM08orf06510	COG3880	PFAM UvrB UvrC protein
SB48_HM08orf06524	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SB48_HM08orf06528	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SB48_HM08orf06530	COG0590	tRNA wobble adenosine to inosine editing
SB48_HM08orf06534	COG3328	transposase activity
SB48_HM08orf06540	COG3858	chitin binding
SB48_HM08orf06540	COG1388	LysM domain
SB48_HM08orf06542	COG1428	Deoxynucleoside kinase
SB48_HM08orf06543	COG1428	Deoxynucleoside kinase
SB48_HM08orf06546	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SB48_HM08orf06548	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SB48_HM08orf06556	COG0516	GMP reductase activity
SB48_HM08orf06556	COG0517	IMP dehydrogenase activity
SB48_HM08orf06569	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SB48_HM08orf06570	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SB48_HM08orf06571	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SB48_HM08orf06573	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SB48_HM08orf06575	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SB48_HM08orf06576	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SB48_HM08orf06578	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SB48_HM08orf06580	COG0037	tRNA processing
SB48_HM08orf06583	COG0515	serine threonine protein kinase
SB48_HM08orf06584	COG2304	oxidoreductase activity
SB48_HM08orf06586	COG2208	phosphoserine phosphatase activity
SB48_HM08orf06592	COG1098	S1 RNA binding domain
SB48_HM08orf06597	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SB48_HM08orf06599	COG3956	TIGRFAM MazG family protein
SB48_HM08orf06602	COG2244	polysaccharide biosynthetic process
SB48_HM08orf06604	COG2002	toxin-antitoxin pair type II binding
SB48_HM08orf06608	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SB48_HM08orf06612	COG0193	aminoacyl-tRNA hydrolase activity
SB48_HM08orf06616	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SB48_HM08orf06618	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SB48_HM08orf06619	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SB48_HM08orf06621	COG0577	efflux transmembrane transporter activity
SB48_HM08orf06621	COG1136	(ABC) transporter
SB48_HM08orf06628	COG0251	oxidation-reduction process
SB48_HM08orf06630	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SB48_HM08orf06632	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SB48_HM08orf06635	COG4466	Protein conserved in bacteria
SB48_HM08orf06639	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SB48_HM08orf06643	COG0084	hydrolase, TatD family'
SB48_HM08orf06649	COG2002	toxin-antitoxin pair type II binding
SB48_HM08orf06652	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SB48_HM08orf06653	COG2827	Endonuclease containing a URI domain
SB48_HM08orf06654	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SB48_HM08orf06656	COG4467	Involved in initiation control of chromosome replication
SB48_HM08orf06657	COG1774	PSP1 C-terminal conserved region
SB48_HM08orf06659	COG0470	DNA polymerase III
SB48_HM08orf06660	COG1728	Protein conserved in bacteria
SB48_HM08orf06662	COG3870	Protein conserved in bacteria
SB48_HM08orf06666	COG1982	Orn Lys Arg decarboxylase major
SB48_HM08orf06667	COG3328	transposase activity
SB48_HM08orf06668	COG3328	transposase activity
SB48_HM08orf06669	COG3437	response regulator, receiver
SB48_HM08orf06671	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SB48_HM08orf06673	COG0187	DNA topoisomerase II activity
SB48_HM08orf06678	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SB48_HM08orf06680	COG2501	S4 domain
SB48_HM08orf06682	COG0592	DNA-directed DNA polymerase activity