locus-tag	class	description
BC6307_00050	COG0456	acetyltransferase
BC6307_00055	COG1304	FMN binding
BC6307_00060	COG2814	Major facilitator Superfamily
BC6307_00065	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BC6307_00070	COG1131	(ABC) transporter
BC6307_00090	COG1595	DNA-templated transcription, initiation
BC6307_00100	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BC6307_00110	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BC6307_00115	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BC6307_00120	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BC6307_00125	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BC6307_00130	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BC6307_00135	COG0047	phosphoribosylformylglycinamidine synthase activity
BC6307_00140	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BC6307_00145	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BC6307_00150	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BC6307_00155	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BC6307_00165	COG0151	Belongs to the GarS family
BC6307_00175	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BC6307_00180	COG1470	cell adhesion involved in biofilm formation
BC6307_00185	COG4496	protein, YerC YecD
BC6307_00190	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
BC6307_00195	COG0210	DNA helicase
BC6307_00200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BC6307_00205	COG4851	CamS sex pheromone cAM373 precursor
BC6307_00210	COG1012	belongs to the aldehyde dehydrogenase family
BC6307_00215	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BC6307_00220	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BC6307_00225	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BC6307_00230	COG0154	amidase activity
BC6307_00240	COG2190	(PTS) system
BC6307_00240	COG1263	PTS System
BC6307_00240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BC6307_00245	COG1585	Membrane protein implicated in regulation of membrane protease activity
BC6307_00250	COG2268	Band 7 protein
BC6307_00255	COG1597	lipid kinase activity
BC6307_00265	COG1902	pentaerythritol trinitrate reductase activity
BC6307_00280	COG1733	regulation of RNA biosynthetic process
BC6307_00285	COG2514	catechol 2,3-dioxygenase activity
BC6307_00315	COG1473	amidohydrolase
BC6307_00325	COG4948	Mandelate Racemase Muconate Lactonizing
BC6307_00330	COG3949	Membrane
BC6307_00335	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BC6307_00340	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BC6307_00345	COG4807	Protein conserved in bacteria
BC6307_00350	COG1595	DNA-templated transcription, initiation
BC6307_00375	COG0167	dihydroorotate dehydrogenase activity
BC6307_00380	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BC6307_00405	COG2258	MOSC domain
BC6307_00410	COG2239	Acts as a magnesium transporter
BC6307_00440	COG1193	negative regulation of DNA recombination
BC6307_00445	COG1272	protein, Hemolysin III
BC6307_00465	COG2723	6-phospho-beta-galactosidase activity
BC6307_00475	COG1175	transmembrane transport
BC6307_00480	COG0395	ABC-type sugar transport system, permease component
BC6307_00485	COG5578	integral membrane protein
BC6307_00490	COG3316	Transposase and inactivated derivatives
BC6307_00510	COG1595	DNA-templated transcription, initiation
BC6307_00525	COG4521	taurine ABC transporter
BC6307_00530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BC6307_00535	COG1116	anion transmembrane transporter activity
BC6307_00540	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BC6307_00555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BC6307_00575	COG0514	ATP-dependent DNA helicase (RecQ)
BC6307_00580	COG0745	RESPONSE REGULATOR receiver
BC6307_00600	COG1785	Belongs to the alkaline phosphatase family
BC6307_00630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC6307_00655	COG0861	Integral membrane protein TerC family
BC6307_00670	COG0346	lactoylglutathione lyase activity
BC6307_00675	COG1027	Aspartate ammonia-lyase
BC6307_00685	COG2076	Multidrug Resistance protein
BC6307_00695	COG1309	transcriptional regulator
BC6307_00745	COG1695	Transcriptional regulator
BC6307_00760	COG2409	Drug exporters of the RND superfamily
BC6307_00770	COG4895	conserved protein (DUF2196)
BC6307_00775	COG3344	reverse transcriptase
BC6307_00795	COG1408	metallophosphoesterase
BC6307_00805	COG0745	RESPONSE REGULATOR receiver
BC6307_00810	COG5002	protein histidine kinase activity
BC6307_00815	COG1136	(ABC) transporter
BC6307_00825	COG0517	IMP dehydrogenase activity
BC6307_00825	COG4175	Glycine betaine
BC6307_00840	COG1737	Transcriptional regulator
BC6307_00845	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BC6307_00850	COG2610	gluconate transmembrane transporter activity
BC6307_00855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BC6307_00860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BC6307_00865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BC6307_00870	COG1120	ATPase activity
BC6307_00875	COG0492	ferredoxin-NADP+ reductase activity
BC6307_00880	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BC6307_00885	COG0390	transport system, permease component
BC6307_00900	COG1183	phosphatidylcholine synthase activity
BC6307_00905	COG1609	Transcriptional regulator
BC6307_00910	COG0166	Belongs to the GPI family
BC6307_00925	COG3173	Aminoglycoside phosphotransferase
BC6307_00930	COG0154	amidase activity
BC6307_00940	COG2368	4-hydroxyphenylacetate
BC6307_00955	COG0084	hydrolase, TatD family'
BC6307_00960	COG1132	(ABC) transporter
BC6307_00965	COG1132	(ABC) transporter
BC6307_00975	COG1115	amino acid carrier protein
BC6307_00980	COG0723	plastoquinol--plastocyanin reductase activity
BC6307_00980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BC6307_00990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BC6307_01000	COG3316	Transposase and inactivated derivatives
BC6307_01010	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BC6307_01020	COG0145	ligase activity
BC6307_01025	COG2124	cytochrome p450
BC6307_01035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BC6307_01045	COG2244	polysaccharide biosynthetic process
BC6307_01055	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
BC6307_01070	COG1077	Cell shape determining protein MreB Mrl
BC6307_01095	COG2814	Major facilitator Superfamily
BC6307_01110	COG1115	amino acid carrier protein
BC6307_01125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC6307_01135	COG1904	glucuronate isomerase
BC6307_01140	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BC6307_01145	COG1917	Cupin 2, conserved barrel domain protein
BC6307_01145	COG2207	Transcriptional regulator
BC6307_01155	COG0673	inositol 2-dehydrogenase activity
BC6307_01170	COG2211	Major facilitator Superfamily
BC6307_01175	COG2211	Major facilitator Superfamily
BC6307_01180	COG1940	carbohydrate kinase activity
BC6307_01190	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_01195	COG1606	tRNA processing
BC6307_01200	COG1070	Carbohydrate kinase
BC6307_01205	COG1691	(AIR) carboxylase
BC6307_01210	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
BC6307_01215	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
BC6307_01220	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BC6307_01225	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BC6307_01235	COG5002	protein histidine kinase activity
BC6307_01240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BC6307_01265	COG1988	membrane-bound metal-dependent
BC6307_01270	COG4840	Belongs to the UPF0435 family
BC6307_01275	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BC6307_01285	COG1295	ribonuclease BN
BC6307_01305	COG2217	Heavy metal translocating P-type atpase
BC6307_01310	COG0477	Major facilitator Superfamily
BC6307_01320	COG2364	Membrane
BC6307_01340	COG0535	radical SAM domain protein
BC6307_01420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BC6307_01425	COG1104	cysteine desulfurase activity
BC6307_01430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_01435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_01435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC6307_01440	COG2814	Major facilitator Superfamily
BC6307_01445	COG1196	nuclear chromosome segregation
BC6307_01495	COG0785	Cytochrome C biogenesis protein
BC6307_01500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BC6307_01505	COG0745	RESPONSE REGULATOR receiver
BC6307_01510	COG3850	Histidine kinase
BC6307_01510	COG5002	protein histidine kinase activity
BC6307_01515	COG0737	Belongs to the 5'-nucleotidase family
BC6307_01530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_01530	COG0425	Belongs to the sulfur carrier protein TusA family
BC6307_01535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_01535	COG0425	Belongs to the sulfur carrier protein TusA family
BC6307_01540	COG2210	Belongs to the sulfur carrier protein TusA family
BC6307_01545	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_01545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC6307_01550	COG0425	Belongs to the sulfur carrier protein TusA family
BC6307_01560	COG0288	reversible hydration of carbon dioxide
BC6307_01585	COG1937	Protein conserved in bacteria
BC6307_01590	COG0425	Belongs to the sulfur carrier protein TusA family
BC6307_01595	COG2210	Belongs to the sulfur carrier protein TusA family
BC6307_01605	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_01610	COG0425	Belongs to the sulfur carrier protein TusA family
BC6307_01610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_01620	COG2210	Belongs to the sulfur carrier protein TusA family
BC6307_01625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_01625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC6307_01630	COG0425	Belongs to the sulfur carrier protein TusA family
BC6307_01640	COG0662	Cupin 2, conserved barrel domain protein
BC6307_01645	COG0446	pyridine nucleotide-disulphide oxidoreductase
BC6307_01660	COG0653	protein targeting
BC6307_01670	COG0515	serine threonine protein kinase
BC6307_01740	COG3773	Cell wall hydrolase
BC6307_01755	COG0697	spore germination
BC6307_01770	COG0402	S-adenosylhomocysteine deaminase activity
BC6307_01790	COG1114	Component of the transport system for branched-chain amino acids
BC6307_01795	COG0659	secondary active sulfate transmembrane transporter activity
BC6307_01815	COG1063	alcohol dehydrogenase
BC6307_01845	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BC6307_01855	COG1307	EDD domain protein, DegV family
BC6307_01870	COG3290	protein histidine kinase activity
BC6307_01870	COG3829	transcription factor binding
BC6307_01880	COG1012	belongs to the aldehyde dehydrogenase family
BC6307_01885	COG0564	pseudouridine synthase activity
BC6307_01890	COG1329	Transcriptional regulator
BC6307_01910	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BC6307_01915	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BC6307_01930	COG0109	protoheme IX farnesyltransferase activity
BC6307_01935	COG1959	2 iron, 2 sulfur cluster binding
BC6307_01940	COG2910	NAD(P)H-binding
BC6307_01950	COG3481	metal-dependent phosphohydrolase, HD sub domain
BC6307_01970	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BC6307_01980	COG1136	(ABC) transporter
BC6307_02000	COG3620	sequence-specific DNA binding
BC6307_02015	COG2072	flavoprotein involved in K transport
BC6307_02020	COG2217	Heavy metal translocating P-type atpase
BC6307_02025	COG3300	MHYT domain
BC6307_02025	COG5001	Diguanylate cyclase
BC6307_02030	COG0697	spore germination
BC6307_02035	COG0814	amino acid
BC6307_02060	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BC6307_02070	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BC6307_02085	COG0640	Transcriptional regulator
BC6307_02090	COG3832	glyoxalase III activity
BC6307_02095	COG3706	GGDEF domain
BC6307_02105	COG2323	membrane
BC6307_02110	COG0038	chloride channel
BC6307_02120	COG4555	ABC transporter
BC6307_02130	COG0656	L-ascorbic acid biosynthetic process
BC6307_02135	COG1131	(ABC) transporter
BC6307_02140	COG0842	Transport permease protein
BC6307_02140	COG1511	domain protein
BC6307_02150	COG1363	Peptidase, m42
BC6307_02180	COG0673	inositol 2-dehydrogenase activity
BC6307_02185	COG0673	inositol 2-dehydrogenase activity
BC6307_02210	COG2233	PERMEase
BC6307_02225	COG0840	transmembrane signaling receptor activity
BC6307_02230	COG0460	homoserine dehydrogenase
BC6307_02235	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BC6307_02240	COG0083	homoserine kinase activity
BC6307_02245	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BC6307_02250	COG0129	dihydroxy-acid dehydratase activity
BC6307_02255	COG0028	Belongs to the TPP enzyme family
BC6307_02260	COG0440	acetolactate synthase activity
BC6307_02265	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BC6307_02270	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BC6307_02280	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BC6307_02285	COG0066	3-isopropylmalate dehydratase activity
BC6307_02290	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BC6307_02295	COG1404	Belongs to the peptidase S8 family
BC6307_02300	COG2208	phosphoserine phosphatase activity
BC6307_02305	COG0596	Alpha beta hydrolase
BC6307_02325	COG0493	'glutamate synthase
BC6307_02325	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BC6307_02335	COG0686	Belongs to the AlaDH PNT family
BC6307_02340	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BC6307_02340	COG2508	Transcriptional regulator
BC6307_02350	COG2409	Drug exporters of the RND superfamily
BC6307_02360	COG2814	Major facilitator Superfamily
BC6307_02370	COG3316	Transposase and inactivated derivatives
BC6307_02375	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BC6307_02385	COG1595	DNA-templated transcription, initiation
BC6307_02390	COG1757	Na H antiporter
BC6307_02395	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BC6307_02410	COG0395	ABC-type sugar transport system, permease component
BC6307_02425	COG0733	neurotransmitter:sodium symporter activity
BC6307_02455	COG5577	PFAM Coat F domain
BC6307_02470	COG0427	acetyl-CoA hydrolase
BC6307_02475	COG1619	proteins homologs of microcin C7 resistance protein MccF
BC6307_02480	COG1834	amidinotransferase
BC6307_02485	COG2205	protein histidine kinase activity
BC6307_02495	COG2329	Antibiotic biosynthesis monooxygenase
BC6307_02505	COG1280	lysine exporter protein (LysE YggA)
BC6307_02550	COG0534	Mate efflux family protein
BC6307_02555	COG1309	transcriptional regulator
BC6307_02560	COG2814	Major facilitator Superfamily
BC6307_02595	COG3279	Response regulator of the LytR AlgR family
BC6307_02600	COG4555	ABC transporter
BC6307_02605	COG1668	transmembrane transport
BC6307_02615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BC6307_02625	COG1960	acyl-CoA dehydrogenase activity
BC6307_02635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BC6307_02640	COG1846	Transcriptional regulator
BC6307_02645	COG2814	Major facilitator Superfamily
BC6307_02650	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BC6307_02690	COG1228	amidohydrolase
BC6307_02695	COG1090	epimerase
BC6307_02705	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_02730	COG1988	membrane-bound metal-dependent
BC6307_02735	COG1194	a g-specific adenine glycosylase
BC6307_02755	COG3557	Belongs to the UPF0374 family
BC6307_02760	COG1132	(ABC) transporter
BC6307_02765	COG4129	membrane
BC6307_02775	COG0069	glutamate synthase activity
BC6307_02775	COG0067	glutamate synthase
BC6307_02775	COG0070	glutamate synthase
BC6307_02795	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BC6307_02800	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BC6307_02805	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BC6307_02810	COG2096	Adenosyltransferase
BC6307_02815	COG0735	belongs to the Fur family
BC6307_02930	COG3382	B3 4 domain protein
BC6307_02945	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BC6307_02950	COG2766	serine protein kinase
BC6307_02955	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BC6307_02965	COG0747	negative chemotaxis
BC6307_02980	COG0601	transmembrane transport
BC6307_02985	COG0444	Belongs to the ABC transporter superfamily
BC6307_02990	COG4608	Belongs to the ABC transporter superfamily
BC6307_02995	COG0697	spore germination
BC6307_03030	COG0372	Belongs to the citrate synthase family
BC6307_03035	COG0583	DNA-binding transcription factor activity
BC6307_03050	COG0708	Exodeoxyribonuclease III
BC6307_03055	COG4607	ABC-type enterochelin transport system periplasmic component
BC6307_03060	COG4667	esterase of the alpha-beta hydrolase superfamily
BC6307_03065	COG1164	Oligoendopeptidase f
BC6307_03070	COG4191	Histidine kinase
BC6307_03075	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BC6307_03080	COG4605	iron ion homeostasis
BC6307_03085	COG4604	ABC transporter, ATP-binding protein
BC6307_03090	COG4607	ABC-type enterochelin transport system periplasmic component
BC6307_03095	COG4536	flavin adenine dinucleotide binding
BC6307_03105	COG0840	transmembrane signaling receptor activity
BC6307_03110	COG1404	Belongs to the peptidase S8 family
BC6307_03115	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BC6307_03135	COG1968	undecaprenyl-diphosphatase activity
BC6307_03140	COG2205	protein histidine kinase activity
BC6307_03150	COG0789	Transcriptional regulator
BC6307_03170	COG0564	pseudouridine synthase activity
BC6307_03185	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BC6307_03200	COG1228	amidohydrolase
BC6307_03215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BC6307_03215	COG3153	acetyltransferase
BC6307_03220	COG1388	LysM domain
BC6307_03220	COG0791	NLP P60 protein
BC6307_03235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BC6307_03240	COG2203	Gaf domain
BC6307_03240	COG4585	Histidine kinase
BC6307_03245	COG2197	response regulator
BC6307_03250	COG0431	NADPH-dependent FMN reductase
BC6307_03265	COG2239	Acts as a magnesium transporter
BC6307_03270	COG0730	response to heat
BC6307_03275	COG2719	SpoVR family
BC6307_03305	COG0640	Transcriptional regulator
BC6307_03310	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BC6307_03315	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BC6307_03320	COG0154	amidase activity
BC6307_03340	COG1794	racemase activity, acting on amino acids and derivatives
BC6307_03345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BC6307_03350	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BC6307_03375	COG1131	(ABC) transporter
BC6307_03390	COG0582	viral genome integration into host DNA
BC6307_03405	COG0534	Mate efflux family protein
BC6307_03410	COG2814	Major facilitator Superfamily
BC6307_03420	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BC6307_03435	COG0521	Mo-molybdopterin cofactor biosynthetic process
BC6307_03440	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BC6307_03455	COG0303	'Molybdopterin
BC6307_03460	COG1763	Mo-molybdopterin cofactor biosynthetic process
BC6307_03465	COG0314	molybdopterin synthase activity
BC6307_03470	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BC6307_03495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BC6307_03500	COG0746	molybdenum cofactor guanylyltransferase activity
BC6307_03505	COG0535	radical SAM domain protein
BC6307_03510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BC6307_03515	COG0489	protein tyrosine kinase activity
BC6307_03525	COG0243	molybdopterin cofactor binding
BC6307_03530	COG0437	4 iron, 4 sulfur cluster binding
BC6307_03545	COG1686	Belongs to the peptidase S11 family
BC6307_03560	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BC6307_03595	COG1078	dGTPase activity
BC6307_03600	COG0586	Pfam SNARE associated Golgi protein
BC6307_03610	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BC6307_03615	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BC6307_03625	COG1301	dicarboxylic acid transport
BC6307_03635	COG1970	mechanosensitive ion channel activity
BC6307_03645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BC6307_03655	COG0393	Putative heavy-metal-binding
BC6307_03660	COG3773	Cell wall hydrolase
BC6307_03675	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BC6307_03685	COG1122	ATPase activity
BC6307_03695	COG0352	thiamine-phosphate diphosphorylase activity
BC6307_03700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BC6307_03705	COG2104	thiamine diphosphate biosynthetic process
BC6307_03710	COG2022	thiamine diphosphate biosynthetic process
BC6307_03715	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BC6307_03720	COG0351	phosphomethylpyrimidine kinase
BC6307_03730	COG4989	oxidoreductase activity
BC6307_03745	COG1607	acyl-coa hydrolase
BC6307_03760	COG1132	(ABC) transporter
BC6307_03765	COG1132	(ABC) transporter
BC6307_03770	COG1253	flavin adenine dinucleotide binding
BC6307_03785	COG3842	ATPase activity
BC6307_03790	COG2508	Transcriptional regulator
BC6307_03805	COG0189	ligase activity
BC6307_03810	COG0189	ligase activity
BC6307_03815	COG0189	ligase activity
BC6307_03820	COG0189	ligase activity
BC6307_03830	COG3679	Belongs to the UPF0342 family
BC6307_03835	COG0561	phosphatase activity
BC6307_03840	COG1131	(ABC) transporter
BC6307_03845	COG0842	Transport permease protein
BC6307_03850	COG4585	Histidine kinase
BC6307_03855	COG2197	response regulator
BC6307_03860	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BC6307_03865	COG4412	M6 family metalloprotease domain protein
BC6307_03865	COG1404	Belongs to the peptidase S8 family
BC6307_03885	COG0681	Belongs to the peptidase S26 family
BC6307_03890	COG1024	Enoyl-CoA hydratase
BC6307_03900	COG0420	3'-5' exonuclease activity
BC6307_03905	COG4717	serine-type aminopeptidase activity
BC6307_03910	COG3481	metal-dependent phosphohydrolase, HD sub domain
BC6307_03920	COG2233	PERMEase
BC6307_03925	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BC6307_03955	COG1846	Transcriptional regulator
BC6307_03975	COG0537	adenosine 5'-monophosphoramidase activity
BC6307_03980	COG1131	(ABC) transporter
BC6307_03985	COG4473	ABC transporter
BC6307_03995	COG1473	amidohydrolase
BC6307_04010	COG4585	Histidine kinase
BC6307_04015	COG2197	response regulator
BC6307_04020	COG2329	Antibiotic biosynthesis monooxygenase
BC6307_04025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BC6307_04035	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BC6307_04055	COG1609	Transcriptional regulator
BC6307_04065	COG1234	tRNA 3'-trailer cleavage
BC6307_04070	COG0095	Lipoate-protein ligase
BC6307_04075	COG0318	PFAM AMP-dependent synthetase and ligase
BC6307_04080	COG1024	Enoyl-CoA hydratase
BC6307_04090	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BC6307_04100	COG1999	signal sequence binding
BC6307_04105	COG0501	Belongs to the peptidase M48B family
BC6307_04120	COG2323	membrane
BC6307_04130	COG0823	Involved in the tonB-independent uptake of proteins
BC6307_04135	COG0398	Pfam SNARE associated Golgi protein
BC6307_04145	COG0183	Belongs to the thiolase family
BC6307_04165	COG0411	ABC transporter
BC6307_04175	COG0559	Belongs to the binding-protein-dependent transport system permease family
BC6307_04185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BC6307_04195	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_04200	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BC6307_04205	COG0318	PFAM AMP-dependent synthetase and ligase
BC6307_04215	COG0706	membrane insertase activity
BC6307_04220	COG2814	Major facilitator Superfamily
BC6307_04225	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BC6307_04230	COG1074	ATP-dependent DNA helicase activity
BC6307_04235	COG0420	3'-5' exonuclease activity
BC6307_04240	COG0419	ATPase involved in DNA repair
BC6307_04245	COG1403	HNH endonuclease
BC6307_04285	COG2311	Membrane
BC6307_04295	COG0179	Fumarylacetoacetate (FAA) hydrolase
BC6307_04300	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BC6307_04310	COG3300	MHYT domain
BC6307_04310	COG5001	Diguanylate cyclase
BC6307_04320	COG0367	asparagine synthase
BC6307_04325	COG0004	ammonium transporteR
BC6307_04335	COG0534	Mate efflux family protein
BC6307_04340	COG2207	Transcriptional regulator
BC6307_04340	COG1917	Cupin 2, conserved barrel domain protein
BC6307_04350	COG2182	Extracellular solute-binding protein
BC6307_04355	COG1175	transmembrane transport
BC6307_04360	COG3833	ABC-type maltose transport systems, permease component
BC6307_04365	COG1874	Beta-galactosidase
BC6307_04365	COG0366	Alpha amylase catalytic
BC6307_04370	COG1609	Transcriptional regulator
BC6307_04375	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_04385	COG1666	GTP binding
BC6307_04390	COG2996	Protein conserved in bacteria
BC6307_04400	COG1307	EDD domain protein, DegV family
BC6307_04405	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BC6307_04420	COG0561	phosphatase activity
BC6307_04425	COG1073	alpha beta
BC6307_04430	COG2151	metal-sulfur cluster biosynthetic enzyme
BC6307_04440	COG0542	response to heat
BC6307_04450	COG2267	carboxylic ester hydrolase activity
BC6307_04460	COG1744	ABC transporter substrate-binding protein PnrA-like
BC6307_04475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BC6307_04480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BC6307_04485	COG5504	Zn-dependent protease
BC6307_04490	COG0444	Belongs to the ABC transporter superfamily
BC6307_04495	COG4608	Belongs to the ABC transporter superfamily
BC6307_04505	COG0601	transmembrane transport
BC6307_04510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BC6307_04525	COG0180	Tryptophanyl-tRNA synthetase
BC6307_04540	COG1473	amidohydrolase
BC6307_04555	COG0601	transmembrane transport
BC6307_04560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BC6307_04565	COG0444	Belongs to the ABC transporter superfamily
BC6307_04570	COG4608	Belongs to the ABC transporter superfamily
BC6307_04585	COG0456	acetyltransferase
BC6307_04605	COG1393	Belongs to the ArsC family
BC6307_04610	COG3344	reverse transcriptase
BC6307_04615	COG0861	Integral membrane protein TerC family
BC6307_04625	COG4862	establishment of competence for transformation
BC6307_04630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BC6307_04640	COG1164	Oligoendopeptidase f
BC6307_04660	COG2346	COG2346, Truncated hemoglobins
BC6307_04665	COG0741	lytic transglycosylase activity
BC6307_04670	COG4116	CYTH
BC6307_04680	COG2357	RelA SpoT domain protein
BC6307_04685	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BC6307_04690	COG0564	pseudouridine synthase activity
BC6307_04695	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BC6307_04700	COG0772	Belongs to the SEDS family
BC6307_04705	COG0475	glutathione-regulated potassium exporter activity
BC6307_04705	COG0589	response to stress
BC6307_04760	COG0438	transferase activity, transferring glycosyl groups
BC6307_04810	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BC6307_04815	COG0463	Glycosyl transferase, family 2
BC6307_04860	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BC6307_04875	COG2323	membrane
BC6307_04915	COG0210	DNA helicase
BC6307_04925	COG2323	membrane
BC6307_04935	COG2153	protein acetylation
BC6307_04940	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BC6307_04945	COG2382	esterase
BC6307_04950	COG1116	anion transmembrane transporter activity
BC6307_04965	COG1999	signal sequence binding
BC6307_04975	COG1418	mRNA catabolic process
BC6307_05020	COG2720	vancomycin resistance protein
BC6307_05030	COG1802	Transcriptional regulator
BC6307_05040	COG0601	transmembrane transport
BC6307_05045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BC6307_05055	COG1124	(ABC) transporter
BC6307_05060	COG1114	Component of the transport system for branched-chain amino acids
BC6307_05070	COG3263	regulation of cellular component size
BC6307_05085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BC6307_05110	COG2188	Transcriptional regulator
BC6307_05115	COG1263	PTS System
BC6307_05115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BC6307_05120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BC6307_05125	COG4844	belongs to the
BC6307_05155	COG2270	Major facilitator Superfamily
BC6307_05170	COG0693	protein deglycase activity
BC6307_05210	COG5002	protein histidine kinase activity
BC6307_05230	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BC6307_05235	COG2146	nitrite reductase [NAD(P)H] activity
BC6307_05240	COG1587	Uroporphyrinogen-III synthase
BC6307_05240	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BC6307_05245	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BC6307_05250	COG1177	transmembrane transport
BC6307_05255	COG1176	ABC-type spermidine putrescine transport system, permease component I
BC6307_05260	COG3842	ATPase activity
BC6307_05265	COG1132	(ABC) transporter
BC6307_05290	COG0789	Transcriptional regulator
BC6307_05300	COG2112	serine threonine protein kinase
BC6307_05305	COG0438	transferase activity, transferring glycosyl groups
BC6307_05310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BC6307_05315	COG4191	Histidine kinase
BC6307_05320	COG2105	PFAM AIG2 family protein
BC6307_05320	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
BC6307_05330	COG1979	alcohol dehydrogenase
BC6307_05335	COG2304	oxidoreductase activity
BC6307_05340	COG4129	membrane
BC6307_05425	COG2814	Major facilitator Superfamily
BC6307_05430	COG1595	DNA-templated transcription, initiation
BC6307_05450	COG4533	DNA binding
BC6307_05460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BC6307_05465	COG0840	transmembrane signaling receptor activity
BC6307_05465	COG5278	phosphoserine phosphatase activity
BC6307_05470	COG3340	Belongs to the peptidase S51 family
BC6307_05475	COG2207	Transcriptional regulator
BC6307_05480	COG0789	Transcriptional regulator
BC6307_05485	COG2365	Tyrosine phosphatase family
BC6307_05490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BC6307_05495	COG0765	amino acid transport
BC6307_05500	COG1126	abc transporter atp-binding protein
BC6307_05515	COG1132	(ABC) transporter
BC6307_05520	COG3316	Transposase and inactivated derivatives
BC6307_05545	COG0697	spore germination
BC6307_05550	COG0628	permease
BC6307_05585	COG5001	Diguanylate cyclase
BC6307_05585	COG3706	GGDEF domain
BC6307_05585	COG2203	Gaf domain
BC6307_05585	COG4251	negative regulation of phosphorylation
BC6307_05600	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BC6307_05605	COG0579	oxidoreductase
BC6307_05620	COG1649	PFAM Uncharacterised BCR, COG1649
BC6307_05625	COG3773	Cell wall hydrolase
BC6307_05640	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BC6307_05660	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BC6307_05665	COG1012	belongs to the aldehyde dehydrogenase family
BC6307_05675	COG1506	peptidase
BC6307_05675	COG4946	Tricorn protease homolog
BC6307_05675	COG0823	Involved in the tonB-independent uptake of proteins
BC6307_05680	COG1609	Transcriptional regulator
BC6307_05685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BC6307_05685	COG1263	PTS System
BC6307_05690	COG1621	beta-fructofuranosidase activity
BC6307_05695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BC6307_05700	COG0702	epimerase
BC6307_05720	COG1396	sequence-specific DNA binding
BC6307_05735	COG0561	phosphatase activity
BC6307_05740	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BC6307_05745	COG0583	DNA-binding transcription factor activity
BC6307_05755	COG1595	DNA-templated transcription, initiation
BC6307_05780	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BC6307_05810	COG1476	TRANSCRIPTIONal
BC6307_05835	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BC6307_05845	COG2851	Citrate transporter
BC6307_05850	COG4565	transcriptional regulatory protein
BC6307_05855	COG3290	protein histidine kinase activity
BC6307_05860	COG5001	Diguanylate cyclase
BC6307_05860	COG3300	MHYT domain
BC6307_05870	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BC6307_05885	COG0450	alkyl hydroperoxide reductase
BC6307_05890	COG3634	alkyl hydroperoxide reductase activity
BC6307_05925	COG5578	integral membrane protein
BC6307_05930	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BC6307_05935	COG3458	cephalosporin-C deacetylase activity
BC6307_05940	COG1737	Transcriptional regulator
BC6307_05950	COG4209	transmembrane transport
BC6307_05955	COG0395	ABC-type sugar transport system, permease component
BC6307_05960	COG1653	transport
BC6307_05975	COG1472	Belongs to the glycosyl hydrolase 3 family
BC6307_05985	COG1940	carbohydrate kinase activity
BC6307_05995	COG4145	pantothenate transmembrane transporter activity
BC6307_06000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BC6307_06005	COG0473	3-isopropylmalate dehydrogenase activity
BC6307_06015	COG1012	belongs to the aldehyde dehydrogenase family
BC6307_06020	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BC6307_06025	COG1522	sequence-specific DNA binding
BC6307_06035	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BC6307_06040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BC6307_06045	COG0745	RESPONSE REGULATOR receiver
BC6307_06050	COG3850	Histidine kinase
BC6307_06050	COG5002	protein histidine kinase activity
BC6307_06055	COG1136	(ABC) transporter
BC6307_06065	COG0745	RESPONSE REGULATOR receiver
BC6307_06070	COG2205	protein histidine kinase activity
BC6307_06075	COG1136	(ABC) transporter
BC6307_06080	COG0577	efflux transmembrane transporter activity
BC6307_06100	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BC6307_06105	COG1126	abc transporter atp-binding protein
BC6307_06110	COG0765	amino acid transport
BC6307_06115	COG0765	amino acid transport
BC6307_06120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BC6307_06125	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BC6307_06140	COG2030	dehydratase
BC6307_06145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BC6307_06160	COG0411	ABC transporter
BC6307_06170	COG0559	Belongs to the binding-protein-dependent transport system permease family
BC6307_06195	COG0446	pyridine nucleotide-disulphide oxidoreductase
BC6307_06220	COG1136	(ABC) transporter
BC6307_06245	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_06250	COG0668	transmembrane transport
BC6307_06260	COG0477	Major facilitator Superfamily
BC6307_06295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BC6307_06300	COG1250	3-hydroxyacyl-CoA dehydrogenase
BC6307_06310	COG4948	Mandelate Racemase Muconate Lactonizing
BC6307_06315	COG1288	antiporter activity
BC6307_06325	COG1473	amidohydrolase
BC6307_06340	COG0791	NLP P60 protein
BC6307_06340	COG1388	LysM domain
BC6307_06345	COG0745	RESPONSE REGULATOR receiver
BC6307_06350	COG3850	Histidine kinase
BC6307_06350	COG5002	protein histidine kinase activity
BC6307_06360	COG0577	efflux transmembrane transporter activity
BC6307_06365	COG1136	(ABC) transporter
BC6307_06370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BC6307_06380	COG0737	Belongs to the 5'-nucleotidase family
BC6307_06385	COG1191	sigma factor activity
BC6307_06405	COG1584	GPR1 FUN34 yaaH family protein
BC6307_06410	COG1657	PFAM Prenyltransferase squalene oxidase
BC6307_06435	COG2226	methyltransferase
BC6307_06445	COG2267	carboxylic ester hydrolase activity
BC6307_06465	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BC6307_06475	COG1476	TRANSCRIPTIONal
BC6307_06480	COG2207	Transcriptional regulator
BC6307_06515	COG0702	epimerase
BC6307_06530	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BC6307_06545	COG1115	amino acid carrier protein
BC6307_06550	COG1215	transferase activity, transferring glycosyl groups
BC6307_06555	COG1414	Transcriptional regulator
BC6307_06560	COG0531	amino acid
BC6307_06635	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
BC6307_06650	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BC6307_06655	COG0456	acetyltransferase
BC6307_06670	COG0653	protein targeting
BC6307_06680	COG0745	RESPONSE REGULATOR receiver
BC6307_06695	COG2205	protein histidine kinase activity
BC6307_06735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BC6307_06745	COG2814	Major facilitator Superfamily
BC6307_06750	COG0640	Transcriptional regulator
BC6307_06830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BC6307_06850	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_06860	COG4145	pantothenate transmembrane transporter activity
BC6307_06870	COG0726	polysaccharide deacetylase
BC6307_06910	COG2197	response regulator
BC6307_06950	COG2200	EAL domain
BC6307_06960	COG3119	arylsulfatase activity
BC6307_06970	COG2746	aminoglycoside 3-N-acetyltransferase activity
BC6307_06980	COG0493	'glutamate synthase
BC6307_07035	COG2031	fatty acid transporter
BC6307_07045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BC6307_07050	COG1653	transport
BC6307_07055	COG1175	transmembrane transport
BC6307_07060	COG0395	ABC-type sugar transport system, permease component
BC6307_07065	COG1082	Xylose isomerase domain protein TIM barrel
BC6307_07070	COG2814	Major facilitator Superfamily
BC6307_07080	COG2222	sugar isomerase
BC6307_07085	COG0322	excinuclease ABC activity
BC6307_07110	COG1204	response to ionizing radiation
BC6307_07170	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BC6307_07175	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BC6307_07185	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BC6307_07215	COG1401	restriction endodeoxyribonuclease activity
BC6307_07230	COG0494	nUDIX hydrolase
BC6307_07260	COG1401	restriction endodeoxyribonuclease activity
BC6307_07275	COG0583	DNA-binding transcription factor activity
BC6307_07280	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BC6307_07350	COG1192	Involved in chromosome partitioning
BC6307_07375	COG1595	DNA-templated transcription, initiation
BC6307_07390	COG5646	InterPro IPR014922
BC6307_07395	COG2222	sugar isomerase
BC6307_07400	COG1653	transport
BC6307_07405	COG1175	transmembrane transport
BC6307_07410	COG0395	ABC-type sugar transport system, permease component
BC6307_07415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BC6307_07420	COG2188	Transcriptional regulator
BC6307_07425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BC6307_07435	COG1404	Belongs to the peptidase S8 family
BC6307_07440	COG1595	DNA-templated transcription, initiation
BC6307_07455	COG1136	(ABC) transporter
BC6307_07470	COG0110	maltose O-acetyltransferase activity
BC6307_07480	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BC6307_07515	COG0110	maltose O-acetyltransferase activity
BC6307_07540	COG2385	sporulation resulting in formation of a cellular spore
BC6307_07540	COG2247	cell wall binding repeat
BC6307_07560	COG0477	Major facilitator Superfamily
BC6307_07605	COG1280	lysine exporter protein (LysE YggA)
BC6307_07610	COG1378	Sugar-specific transcriptional regulator TrmB
BC6307_07640	COG5504	Zn-dependent protease
BC6307_07665	COG0454	-acetyltransferase
BC6307_07670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BC6307_07710	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BC6307_07715	COG3844	kynureninase activity
BC6307_07720	COG1309	transcriptional regulator
BC6307_07730	COG0494	nUDIX hydrolase
BC6307_07735	COG0494	nUDIX hydrolase
BC6307_07750	COG0500	methyltransferase
BC6307_07750	COG3615	Tellurite resistance protein tehB
BC6307_07755	COG0681	Belongs to the peptidase S26 family
BC6307_07775	COG0154	amidase activity
BC6307_07890	COG0488	(ABC) transporter
BC6307_07895	COG2746	aminoglycoside 3-N-acetyltransferase activity
BC6307_07910	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BC6307_07945	COG1846	Transcriptional regulator
BC6307_07950	COG0456	acetyltransferase
BC6307_07955	COG2808	Putative FMN-binding domain
BC6307_07985	COG0202	RNA polymerase activity
BC6307_08025	COG1595	DNA-templated transcription, initiation
BC6307_08040	COG2226	methyltransferase
BC6307_08060	COG1063	alcohol dehydrogenase
BC6307_08090	COG1164	Oligoendopeptidase f
BC6307_08100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BC6307_08110	COG1595	DNA-templated transcription, initiation
BC6307_08125	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BC6307_08130	COG4978	Transcriptional regulator
BC6307_08130	COG0789	Transcriptional regulator
BC6307_08135	COG2814	Major facilitator Superfamily
BC6307_08190	COG1309	transcriptional regulator
BC6307_08205	COG0753	catalase activity
BC6307_08225	COG2323	membrane
BC6307_08230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BC6307_08245	COG1595	DNA-templated transcription, initiation
BC6307_08260	COG2226	methyltransferase
BC6307_08275	COG2213	PTS system mannitol-specific
BC6307_08275	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BC6307_08280	COG3711	transcriptional antiterminator
BC6307_08330	COG2135	peptidase activity
BC6307_08355	COG0778	Nitroreductase
BC6307_08360	COG0346	lactoylglutathione lyase activity
BC6307_08365	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BC6307_08370	COG0346	lactoylglutathione lyase activity
BC6307_08375	COG0400	carboxylic ester hydrolase activity
BC6307_08380	COG2259	Doxx family
BC6307_08390	COG0662	Cupin 2, conserved barrel domain protein
BC6307_08395	COG0697	spore germination
BC6307_08400	COG1522	sequence-specific DNA binding
BC6307_08420	COG4149	molybdate abc transporter
BC6307_08425	COG1846	Transcriptional regulator
BC6307_08430	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BC6307_08445	COG1714	RDD family
BC6307_08465	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BC6307_08500	COG1595	DNA-templated transcription, initiation
BC6307_08530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BC6307_08540	COG4682	membrane
BC6307_08550	COG0697	spore germination
BC6307_08555	COG1917	Cupin 2, conserved barrel domain protein
BC6307_08555	COG2207	Transcriptional regulator
BC6307_08590	COG1051	belongs to the nudix hydrolase family
BC6307_08640	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BC6307_08660	COG1131	(ABC) transporter
BC6307_08675	COG0714	Associated with various cellular activities
BC6307_08695	COG2364	Membrane
BC6307_08705	COG0114	fumarate hydratase activity
BC6307_08725	COG0435	Glutathione S-transferase
BC6307_08735	COG0300	oxidoreductase activity
BC6307_08740	COG3118	belongs to the thioredoxin family
BC6307_08755	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BC6307_08755	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BC6307_08765	COG1405	negative regulation of cell septum assembly
BC6307_08765	COG3012	SEC-C Motif Domain Protein
BC6307_08770	COG0436	Aminotransferase
BC6307_08775	COG2329	Antibiotic biosynthesis monooxygenase
BC6307_08785	COG1929	Belongs to the glycerate kinase type-1 family
BC6307_08800	COG1271	oxidase subunit
BC6307_08805	COG1294	oxidase, subunit
BC6307_08810	COG4988	ABC transporter
BC6307_08815	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BC6307_08820	COG2764	glyoxalase bleomycin resistance protein dioxygenase
BC6307_08835	COG1309	transcriptional regulator
BC6307_08840	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BC6307_08845	COG1278	Cold shock
BC6307_08850	COG3344	reverse transcriptase
BC6307_08870	COG1131	(ABC) transporter
BC6307_08875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BC6307_08900	COG1363	Peptidase, m42
BC6307_08905	COG1533	DNA photolyase activity
BC6307_08920	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BC6307_08925	COG2224	Isocitrate lyase
BC6307_08940	COG2814	Major facilitator Superfamily
BC6307_08955	COG1388	LysM domain
BC6307_08955	COG3584	3D domain protein
BC6307_08995	COG0668	transmembrane transport
BC6307_09005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BC6307_09020	COG1793	dna ligase
BC6307_09020	COG3285	dna ligase
BC6307_09025	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BC6307_09040	COG1191	sigma factor activity
BC6307_09055	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BC6307_09060	COG2814	Major facilitator Superfamily
BC6307_09080	COG5002	protein histidine kinase activity
BC6307_09085	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BC6307_09100	COG0640	Transcriptional regulator
BC6307_09105	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BC6307_09110	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
BC6307_09115	COG1278	Cold shock
BC6307_09120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BC6307_09125	COG0436	Aminotransferase
BC6307_09130	COG1850	ribulose-bisphosphate carboxylase activity
BC6307_09135	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
BC6307_09140	COG0235	Class ii aldolase
BC6307_09145	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BC6307_09155	COG2861	carbohydrate metabolic process
BC6307_09175	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BC6307_09180	COG3639	organic phosphonate transmembrane transporter activity
BC6307_09185	COG3639	organic phosphonate transmembrane transporter activity
BC6307_09190	COG0737	Belongs to the 5'-nucleotidase family
BC6307_09195	COG1846	Transcriptional regulator
BC6307_09205	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BC6307_09220	COG3949	Membrane
BC6307_09225	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BC6307_09240	COG0720	synthase
BC6307_09250	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BC6307_09260	COG4873	Protein conserved in bacteria
BC6307_09305	COG1725	Transcriptional regulator
BC6307_09310	COG1131	(ABC) transporter
BC6307_09320	COG1131	(ABC) transporter
BC6307_09325	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BC6307_09330	COG1136	(ABC) transporter
BC6307_09335	COG0577	efflux transmembrane transporter activity
BC6307_09340	COG0726	polysaccharide deacetylase
BC6307_09360	COG0714	Associated with various cellular activities
BC6307_09395	COG3546	catalase activity
BC6307_09400	COG1388	LysM domain
BC6307_09400	COG0791	NLP P60 protein
BC6307_09435	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_09450	COG2986	histidine ammonia-lyase
BC6307_09455	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BC6307_09465	COG0010	Belongs to the arginase family
BC6307_09470	COG3859	Proton-coupled thiamine transporter YuaJ
BC6307_09475	COG2084	Dehydrogenase
BC6307_09480	COG4191	Histidine kinase
BC6307_09485	COG0733	neurotransmitter:sodium symporter activity
BC6307_09495	COG0436	Aminotransferase
BC6307_09505	COG5582	Belongs to the UPF0302 family
BC6307_09515	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_09525	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BC6307_09530	COG3594	Acyltransferase
BC6307_09535	COG1607	acyl-coa hydrolase
BC6307_09545	COG1278	Cold shock
BC6307_09550	COG4191	Histidine kinase
BC6307_09555	COG1388	LysM domain
BC6307_09555	COG3584	3D domain protein
BC6307_09565	COG1404	Belongs to the peptidase S8 family
BC6307_09570	COG3620	sequence-specific DNA binding
BC6307_09585	COG0596	Alpha beta hydrolase
BC6307_09590	COG3011	Protein conserved in bacteria
BC6307_09595	COG5522	Integral membrane protein (intg_mem_TP0381)
BC6307_09605	COG1349	DNA-binding transcription factor activity
BC6307_09610	COG1105	Belongs to the carbohydrate kinase PfkB family
BC6307_09615	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BC6307_09615	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BC6307_09615	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BC6307_09625	COG3663	DNA glycosylase
BC6307_09635	COG0346	lactoylglutathione lyase activity
BC6307_09655	COG0714	Associated with various cellular activities
BC6307_09690	COG1842	Phage shock protein A
BC6307_09705	COG2197	response regulator
BC6307_09735	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BC6307_09740	COG0326	Molecular chaperone. Has ATPase activity
BC6307_09755	COG4152	abc transporter atp-binding protein
BC6307_09760	COG2309	aminopeptidase activity
BC6307_09785	COG1388	LysM domain
BC6307_09785	COG3858	chitin binding
BC6307_09800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BC6307_09815	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BC6307_09825	COG0745	RESPONSE REGULATOR receiver
BC6307_09830	COG5002	protein histidine kinase activity
BC6307_09845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BC6307_09855	COG1686	Belongs to the peptidase S11 family
BC6307_09875	COG2190	(PTS) system
BC6307_09880	COG1263	PTS System
BC6307_09880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BC6307_09885	COG0366	Alpha amylase catalytic
BC6307_09895	COG0835	chemotaxis
BC6307_09895	COG0784	Response regulator, receiver
BC6307_09905	COG1408	metallophosphoesterase
BC6307_09910	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_09920	COG2200	EAL domain
BC6307_09935	COG4703	Protein of unknown function (DUF1797)
BC6307_09940	COG5506	Protein of unknown function (DUF1694)
BC6307_09945	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
BC6307_09950	COG0517	IMP dehydrogenase activity
BC6307_09955	COG2814	Major facilitator Superfamily
BC6307_09970	COG0583	DNA-binding transcription factor activity
BC6307_09980	COG2171	N-acyltransferase activity
BC6307_09985	COG1473	amidohydrolase
BC6307_09995	COG0668	transmembrane transport
BC6307_10000	COG1132	(ABC) transporter
BC6307_10005	COG1132	(ABC) transporter
BC6307_10010	COG1199	ATP-dependent helicase activity
BC6307_10010	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BC6307_10030	COG0436	Aminotransferase
BC6307_10035	COG0017	Asparaginyl-tRNA synthetase
BC6307_10040	COG3935	DnaD domain protein
BC6307_10045	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BC6307_10055	COG4499	WXG100 protein secretion system (Wss), protein YukC
BC6307_10055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BC6307_10060	COG3331	DNA recombination
BC6307_10105	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BC6307_10105	COG0392	lysyltransferase activity
BC6307_10110	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BC6307_10115	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BC6307_10120	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BC6307_10125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BC6307_10130	COG0505	Belongs to the CarA family
BC6307_10140	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BC6307_10145	COG0137	argininosuccinate synthase activity
BC6307_10150	COG0165	Argininosuccinate lyase
BC6307_10160	COG1737	Transcriptional regulator
BC6307_10170	COG0363	glucosamine-6-phosphate deaminase activity
BC6307_10175	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BC6307_10180	COG5609	conserved protein (DUF2294)
BC6307_10205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_10210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC6307_10210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_10230	COG1111	helicase
BC6307_10230	COG1205	dead DEAH box helicase
BC6307_10235	COG3359	exonuclease
BC6307_10260	COG0116	Belongs to the methyltransferase superfamily
BC6307_10275	COG1199	ATP-dependent helicase activity
BC6307_10280	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BC6307_10285	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BC6307_10290	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BC6307_10315	COG3424	synthase
BC6307_10320	COG1755	Isoprenylcysteine carboxyl methyltransferase
BC6307_10325	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BC6307_10350	COG5658	integral membrane protein
BC6307_10360	COG1309	transcriptional regulator
BC6307_10365	COG1131	(ABC) transporter
BC6307_10370	COG3559	Exporter of polyketide antibiotics
BC6307_10385	COG0165	Argininosuccinate lyase
BC6307_10400	COG0395	ABC-type sugar transport system, permease component
BC6307_10405	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BC6307_10410	COG3069	C4-dicarboxylate transmembrane transporter activity
BC6307_10420	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_10425	COG3711	transcriptional antiterminator
BC6307_10430	COG1263	PTS System
BC6307_10430	COG2190	(PTS) system
BC6307_10430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BC6307_10445	COG0346	lactoylglutathione lyase activity
BC6307_10450	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BC6307_10460	COG2357	RelA SpoT domain protein
BC6307_10485	COG0328	RNA-DNA hybrid ribonuclease activity
BC6307_10490	COG0328	RNA-DNA hybrid ribonuclease activity
BC6307_10505	COG1278	Cold shock
BC6307_10525	COG4974	Belongs to the 'phage' integrase family
BC6307_10545	COG1937	Protein conserved in bacteria
BC6307_10550	COG2210	Belongs to the sulfur carrier protein TusA family
BC6307_10560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_10565	COG0425	Belongs to the sulfur carrier protein TusA family
BC6307_10565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_10575	COG2210	Belongs to the sulfur carrier protein TusA family
BC6307_10580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC6307_10580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_10585	COG0425	Belongs to the sulfur carrier protein TusA family
BC6307_10600	COG0288	reversible hydration of carbon dioxide
BC6307_10610	COG0726	polysaccharide deacetylase
BC6307_10615	COG1966	Carbon starvation protein
BC6307_10625	COG0517	IMP dehydrogenase activity
BC6307_10635	COG0697	spore germination
BC6307_10690	COG0517	IMP dehydrogenase activity
BC6307_10695	COG0662	Cupin 2, conserved barrel domain protein
BC6307_10705	COG1064	alcohol dehydrogenase
BC6307_10735	COG2226	methyltransferase
BC6307_10755	COG0584	glycerophosphoryl diester phosphodiesterase
BC6307_10770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BC6307_10780	COG2226	methyltransferase
BC6307_10800	COG1307	EDD domain protein, DegV family
BC6307_10810	COG1418	mRNA catabolic process
BC6307_10815	COG0488	(ABC) transporter
BC6307_10820	COG1413	lyase activity
BC6307_10830	COG2136	Putative SAM-dependent methyltransferase
BC6307_10830	COG2521	methyltransferase
BC6307_10850	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BC6307_10855	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BC6307_10865	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BC6307_10875	COG1307	EDD domain protein, DegV family
BC6307_10890	COG1999	signal sequence binding
BC6307_10895	COG2755	lipolytic protein G-D-S-L family
BC6307_10940	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BC6307_10940	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BC6307_10950	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BC6307_10955	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BC6307_10960	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BC6307_10965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BC6307_10970	COG0456	acetyltransferase
BC6307_10975	COG3829	transcription factor binding
BC6307_10980	COG1509	lysine 2,3-aminomutase activity
BC6307_10990	COG4479	Belongs to the UPF0346 family
BC6307_11020	COG0813	purine-nucleoside phosphorylase activity
BC6307_11025	COG1876	peptidase activity
BC6307_11045	COG0400	carboxylic ester hydrolase activity
BC6307_11050	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BC6307_11060	COG3396	Phenylacetate-CoA oxygenase
BC6307_11090	COG1024	Enoyl-CoA hydratase
BC6307_11095	COG1012	belongs to the aldehyde dehydrogenase family
BC6307_11100	COG1250	3-hydroxyacyl-CoA dehydrogenase
BC6307_11105	COG0183	Belongs to the thiolase family
BC6307_11110	COG3327	negative regulation of DNA-templated transcription, initiation
BC6307_11115	COG1943	Transposase
BC6307_11120	COG3344	reverse transcriptase
BC6307_11140	COG4120	Belongs to the binding-protein-dependent transport system permease family
BC6307_11145	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BC6307_11160	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BC6307_11180	COG3185	4-Hydroxyphenylpyruvate dioxygenase
BC6307_11185	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BC6307_11190	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BC6307_11195	COG0179	Fumarylacetoacetate (FAA) hydrolase
BC6307_11205	COG2340	Cysteine-rich secretory protein family
BC6307_11215	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
BC6307_11220	COG0534	Mate efflux family protein
BC6307_11225	COG0861	Integral membrane protein TerC family
BC6307_11230	COG0714	Associated with various cellular activities
BC6307_11235	COG4548	von Willebrand factor, type A
BC6307_11240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BC6307_11260	COG1012	belongs to the aldehyde dehydrogenase family
BC6307_11270	COG3853	Toxic anion resistance protein (TelA)
BC6307_11290	COG3773	Cell wall hydrolase
BC6307_11295	COG2226	methyltransferase
BC6307_11305	COG0488	(ABC) transporter
BC6307_11320	COG1823	symporter activity
BC6307_11330	COG1012	belongs to the aldehyde dehydrogenase family
BC6307_11335	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BC6307_11340	COG0514	ATP-dependent DNA helicase (RecQ)
BC6307_11350	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BC6307_11355	COG2404	hydrolase activity, acting on ester bonds
BC6307_11360	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BC6307_11365	COG2223	nitrite transmembrane transporter activity
BC6307_11375	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BC6307_11400	COG3546	catalase activity
BC6307_11425	COG4589	Belongs to the CDS family
BC6307_11435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BC6307_11445	COG0514	ATP-dependent DNA helicase (RecQ)
BC6307_11450	COG3610	response to peptide
BC6307_11455	COG2966	Psort location CytoplasmicMembrane, score
BC6307_11470	COG0768	penicillin binding
BC6307_11485	COG0542	response to heat
BC6307_11500	COG2323	membrane
BC6307_11510	COG0726	polysaccharide deacetylase
BC6307_11515	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BC6307_11520	COG1733	regulation of RNA biosynthetic process
BC6307_11525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BC6307_11525	COG3153	acetyltransferase
BC6307_11530	COG0456	acetyltransferase
BC6307_11540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BC6307_11570	COG0745	RESPONSE REGULATOR receiver
BC6307_11575	COG3850	Histidine kinase
BC6307_11575	COG5002	protein histidine kinase activity
BC6307_11585	COG3212	peptidase
BC6307_11590	COG1966	Carbon starvation protein
BC6307_11600	COG0003	Pfam Anion-transporting ATPase
BC6307_11605	COG3906	Belongs to the UPF0473 family
BC6307_11630	COG0697	spore germination
BC6307_11640	COG0697	spore germination
BC6307_11645	COG0077	Prephenate dehydratase
BC6307_11650	COG3858	chitin binding
BC6307_11655	COG1404	Belongs to the peptidase S8 family
BC6307_11665	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BC6307_11670	COG3739	integral membrane protein
BC6307_11675	COG3655	Transcriptional regulator
BC6307_11685	COG1247	-acetyltransferase
BC6307_11715	COG0346	lactoylglutathione lyase activity
BC6307_11720	COG2162	N-hydroxyarylamine O-acetyltransferase activity
BC6307_11740	COG3340	Belongs to the peptidase S51 family
BC6307_11775	COG4473	ABC transporter
BC6307_11785	COG1271	oxidase subunit
BC6307_11790	COG1294	oxidase, subunit
BC6307_11795	COG4988	ABC transporter
BC6307_11800	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BC6307_11805	COG1764	response to oxidative stress
BC6307_11835	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BC6307_11835	COG0456	acetyltransferase
BC6307_11890	COG2385	sporulation resulting in formation of a cellular spore
BC6307_11910	COG2207	Transcriptional regulator
BC6307_11910	COG3708	Transcriptional regulator
BC6307_11925	COG1090	epimerase
BC6307_11930	COG0778	Nitroreductase
BC6307_11980	COG0671	phosphoesterase, PA-phosphatase related
BC6307_11985	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BC6307_11990	COG0187	DNA topoisomerase II activity
BC6307_11995	COG1832	CoA-binding protein
BC6307_12000	COG3858	chitin binding
BC6307_12005	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BC6307_12015	COG2843	Capsule synthesis protein
BC6307_12020	COG1051	belongs to the nudix hydrolase family
BC6307_12025	COG4841	protein insertion into membrane
BC6307_12035	COG0824	Thioesterase
BC6307_12055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BC6307_12060	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BC6307_12090	COG1484	DNA-dependent DNA replication
BC6307_12100	COG4846	Membrane protein involved in cytochrome C biogenesis
BC6307_12105	COG2201	protein-glutamate methylesterase activity
BC6307_12110	COG0785	Cytochrome C biogenesis protein
BC6307_12120	COG1132	(ABC) transporter
BC6307_12125	COG1132	(ABC) transporter
BC6307_12130	COG3763	UPF0154 protein
BC6307_12145	COG4224	UPF0291 protein
BC6307_12150	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BC6307_12165	COG0174	glutamine synthetase
BC6307_12170	COG0789	Transcriptional regulator
BC6307_12175	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BC6307_12180	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BC6307_12185	COG2860	membrane
BC6307_12190	COG0464	growth
BC6307_12205	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BC6307_12210	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BC6307_12220	COG4550	Control of competence regulator ComK, YlbF/YmcA
BC6307_12225	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BC6307_12230	COG1013	pyruvate-flavodoxin oxidoreductase activity
BC6307_12235	COG0674	pyruvate-flavodoxin oxidoreductase activity
BC6307_12235	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BC6307_12245	COG2359	stage V sporulation protein S
BC6307_12250	COG1692	metallophosphoesterase
BC6307_12255	COG1418	mRNA catabolic process
BC6307_12260	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BC6307_12265	COG1058	Belongs to the CinA family
BC6307_12265	COG1546	Belongs to the CinA family
BC6307_12270	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BC6307_12275	COG1426	Protein conserved in bacteria
BC6307_12290	COG0300	oxidoreductase activity
BC6307_12295	COG0612	Peptidase, M16
BC6307_12300	COG0612	Peptidase, M16
BC6307_12305	COG2188	Transcriptional regulator
BC6307_12310	COG4980	gas vesicle protein
BC6307_12310	COG1674	ftsk spoiiie
BC6307_12320	COG0740	serine-type endopeptidase activity
BC6307_12325	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BC6307_12330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BC6307_12335	COG0527	aspartate kinase activity
BC6307_12340	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BC6307_12345	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BC6307_12350	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BC6307_12355	COG1873	PFAM PRC-barrel domain
BC6307_12360	COG0612	Peptidase, M16
BC6307_12365	COG0726	polysaccharide deacetylase
BC6307_12370	COG1185	polyribonucleotide nucleotidyltransferase activity
BC6307_12375	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BC6307_12380	COG0196	riboflavin kinase activity
BC6307_12385	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BC6307_12390	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BC6307_12395	COG1550	Protein conserved in bacteria
BC6307_12405	COG1358	cellular component organization or biogenesis
BC6307_12410	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BC6307_12415	COG0195	Participates in both transcription termination and antitermination
BC6307_12420	COG0779	Required for maturation of 30S ribosomal subunits
BC6307_12425	COG2176	DNA-directed DNA polymerase activity
BC6307_12430	COG0750	zinc metalloprotease
BC6307_12435	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BC6307_12440	COG4589	Belongs to the CDS family
BC6307_12445	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BC6307_12465	COG0052	Belongs to the universal ribosomal protein uS2 family
BC6307_12480	COG1191	sigma factor activity
BC6307_12485	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BC6307_12490	COG1776	CheC inhibitor of MCP methylation
BC6307_12495	COG0835	chemotaxis
BC6307_12500	COG0643	Histidine kinase
BC6307_12500	COG2198	Histidine kinase
BC6307_12505	COG2201	protein-glutamate methylesterase activity
BC6307_12510	COG0455	bacterial-type flagellum organization
BC6307_12515	COG1419	protein localization to endoplasmic reticulum
BC6307_12520	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BC6307_12525	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BC6307_12530	COG1684	flagellar biosynthetic protein fliR
BC6307_12535	COG1987	bacterial-type flagellum assembly
BC6307_12540	COG1338	Plays a role in the flagellum-specific transport system
BC6307_12545	COG3190	flagellar
BC6307_12550	COG2201	protein-glutamate methylesterase activity
BC6307_12555	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BC6307_12555	COG1776	CheC inhibitor of MCP methylation
BC6307_12560	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BC6307_12565	COG1580	Controls the rotational direction of flagella during chemotaxis
BC6307_12570	COG1582	Flagellar protein (FlbD)
BC6307_12575	COG4786	Flagellar basal body rod
BC6307_12580	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BC6307_12585	COG3144	bacterial-type flagellum assembly
BC6307_12600	COG1157	protein secretion by the type III secretion system
BC6307_12605	COG1317	bacterial-type flagellum organization
BC6307_12610	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BC6307_12615	COG1766	The M ring may be actively involved in energy transduction
BC6307_12620	COG1677	Flagellar hook-basal body complex protein FliE
BC6307_12625	COG1558	bacterial-type flagellum-dependent cell motility
BC6307_12630	COG1815	bacterial-type flagellum-dependent cell motility
BC6307_12635	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BC6307_12640	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BC6307_12645	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BC6307_12650	COG4974	Belongs to the 'phage' integrase family
BC6307_12655	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BC6307_12660	COG0758	DNA mediated transformation
BC6307_12665	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BC6307_12670	COG0045	succinate-CoA ligase (ADP-forming) activity
BC6307_12675	COG2257	FlhB HrpN YscU SpaS Family
BC6307_12690	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BC6307_12710	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BC6307_12715	COG1837	Belongs to the UPF0109 family
BC6307_12720	COG0228	four-way junction DNA binding
BC6307_12725	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BC6307_12730	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BC6307_12735	COG0552	protein localization to endoplasmic reticulum
BC6307_12740	COG1196	nuclear chromosome segregation
BC6307_12745	COG0571	ribonuclease III activity
BC6307_12750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BC6307_12755	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_12760	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BC6307_12765	COG0416	fatty acid biosynthetic process
BC6307_12775	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BC6307_12780	COG1760	l-serine dehydratase
BC6307_12785	COG1760	l-serine dehydratase
BC6307_12790	COG1461	Dihydroxyacetone kinase
BC6307_12795	COG1302	Protein conserved in bacteria
BC6307_12800	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BC6307_12810	COG1564	THIamine pyrophosphokinase
BC6307_12815	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BC6307_12820	COG1162	GTPase activity
BC6307_12825	COG2815	serine threonine protein kinase
BC6307_12825	COG0515	serine threonine protein kinase
BC6307_12830	COG0631	protein serine/threonine phosphatase activity
BC6307_12835	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BC6307_12840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BC6307_12840	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BC6307_12845	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BC6307_12855	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BC6307_12860	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BC6307_12865	COG1758	RNA polymerase activity
BC6307_12870	COG0194	GDP metabolic process
BC6307_12875	COG2052	Domain of unknown function (DUF370)
BC6307_12880	COG1561	YicC-like family, N-terminal region
BC6307_12885	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BC6307_12895	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BC6307_12900	COG0284	orotidine-5'-phosphate decarboxylase activity
BC6307_12905	COG0167	dihydroorotate dehydrogenase activity
BC6307_12910	COG0543	2 iron, 2 sulfur cluster binding
BC6307_12915	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BC6307_12920	COG0505	Belongs to the CarA family
BC6307_12925	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BC6307_12930	COG0540	Belongs to the ATCase OTCase family
BC6307_12935	COG2233	PERMEase
BC6307_12940	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BC6307_12945	COG0564	pseudouridine synthase activity
BC6307_12955	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BC6307_12960	COG3599	regulation of cell shape
BC6307_12965	COG2302	S4 RNA-binding domain
BC6307_12970	COG0762	integral membrane protein
BC6307_12975	COG1799	cell septum assembly
BC6307_12980	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BC6307_12990	COG1873	PFAM PRC-barrel domain
BC6307_13000	COG1191	sigma factor activity
BC6307_13005	COG1191	sigma factor activity
BC6307_13015	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BC6307_13020	COG0849	cell division
BC6307_13025	COG3856	small basic protein
BC6307_13030	COG3879	Bacterial protein of unknown function (DUF881)
BC6307_13035	COG3879	Bacterial protein of unknown function (DUF881)
BC6307_13040	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BC6307_13045	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BC6307_13050	COG0772	Belongs to the SEDS family
BC6307_13060	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BC6307_13070	COG0768	penicillin binding
BC6307_13080	COG4839	cell division protein FtsL
BC6307_13085	COG0275	rRNA processing
BC6307_13090	COG2001	Belongs to the MraZ family
BC6307_13095	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
BC6307_13105	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BC6307_13110	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BC6307_13115	COG0511	ligase activity, forming carbon-carbon bonds
BC6307_13120	COG0439	Biotin carboxylase
BC6307_13125	COG0454	-acetyltransferase
BC6307_13135	COG1024	Enoyl-CoA hydratase
BC6307_13145	COG1399	metal-binding, possibly nucleic acid-binding protein
BC6307_13150	COG1323	Belongs to the UPF0348 family
BC6307_13155	COG3480	Lon protease (S16) C-terminal proteolytic domain
BC6307_13160	COG1752	Esterase of the alpha-beta hydrolase superfamily
BC6307_13165	COG3314	Sporulation integral membrane protein YlbJ
BC6307_13175	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BC6307_13180	COG0742	ribosomal rna small subunit methyltransferase
BC6307_13200	COG3679	Belongs to the UPF0342 family
BC6307_13230	COG2340	Cysteine-rich secretory protein family
BC6307_13235	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
BC6307_13240	COG2340	Cysteine-rich secretory protein family
BC6307_13260	COG3336	cytochrome c oxidase
BC6307_13285	COG0109	protoheme IX farnesyltransferase activity
BC6307_13290	COG1612	heme a metabolic process
BC6307_13295	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BC6307_13300	COG4838	Belongs to the UPF0358 family
BC6307_13305	COG2066	Belongs to the glutaminase family
BC6307_13310	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BC6307_13315	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BC6307_13325	COG4896	Protein conserved in bacteria
BC6307_13350	COG0483	inositol monophosphate 1-phosphatase activity
BC6307_13360	COG4493	Belongs to the UPF0637 family
BC6307_13365	COG4476	Belongs to the UPF0223 family
BC6307_13375	COG1982	Orn Lys Arg decarboxylase major
BC6307_13385	COG1846	Transcriptional regulator
BC6307_13390	COG0386	Belongs to the glutathione peroxidase family
BC6307_13415	COG0508	dehydrogenase complex catalyzes the overall conversion of
BC6307_13420	COG0022	dehydrogenase e1 component
BC6307_13445	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BC6307_13450	COG0569	domain protein
BC6307_13455	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BC6307_13480	COG0438	transferase activity, transferring glycosyl groups
BC6307_13485	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BC6307_13490	COG1803	Methylglyoxal synthase
BC6307_13495	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BC6307_13500	COG1694	Mazg nucleotide pyrophosphohydrolase
BC6307_13505	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BC6307_13510	COG2738	Putative neutral zinc metallopeptidase
BC6307_13520	COG4347	Protein of unknown function (DUF1405)
BC6307_13530	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BC6307_13545	COG5582	Belongs to the UPF0302 family
BC6307_13550	COG0457	Tetratricopeptide repeat
BC6307_13560	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BC6307_13565	COG0287	Prephenate dehydrogenase
BC6307_13570	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BC6307_13575	COG0159	tryptophan synthase activity
BC6307_13580	COG0133	tryptophan synthase activity
BC6307_13585	COG0135	phosphoribosylanthranilate isomerase activity
BC6307_13590	COG0134	indole-3-glycerol-phosphate synthase activity
BC6307_13595	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BC6307_13600	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BC6307_13605	COG4401	Chorismate mutase type I
BC6307_13610	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BC6307_13615	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BC6307_13620	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BC6307_13625	COG0105	UTP biosynthetic process
BC6307_13630	COG0142	geranyltranstransferase activity
BC6307_13635	COG2226	methyltransferase
BC6307_13640	COG0142	geranyltranstransferase activity
BC6307_13650	COG0302	gtp cyclohydrolase
BC6307_13655	COG0776	regulation of translation
BC6307_13660	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BC6307_13680	COG1160	GTP binding
BC6307_13705	COG1304	FMN binding
BC6307_13710	COG0539	negative regulation of cytoplasmic translation
BC6307_13715	COG0204	Acyl-transferase
BC6307_13735	COG2959	enzyme of heme biosynthesis
BC6307_13740	COG3773	Cell wall hydrolase
BC6307_13740	COG3409	Peptidoglycan-binding domain 1 protein
BC6307_13745	COG2339	peptidase activity
BC6307_13755	COG0492	ferredoxin-NADP+ reductase activity
BC6307_13760	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BC6307_13765	COG4862	establishment of competence for transformation
BC6307_13770	COG1408	metallophosphoesterase
BC6307_13785	COG1388	LysM domain
BC6307_13790	COG1266	CAAX protease self-immunity
BC6307_13795	COG0514	ATP-dependent DNA helicase (RecQ)
BC6307_13800	COG4955	Helix-turn-helix domain
BC6307_13805	COG1141	Ferredoxin
BC6307_13810	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BC6307_13825	COG1595	DNA-templated transcription, initiation
BC6307_13840	COG5002	protein histidine kinase activity
BC6307_13845	COG0745	RESPONSE REGULATOR receiver
BC6307_13850	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BC6307_13855	COG1333	cytochrome c biogenesis protein
BC6307_13860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BC6307_13865	COG1187	pseudouridine synthase activity
BC6307_13870	COG0700	Nucleoside recognition
BC6307_13875	COG2715	membrane protein required for spore maturation
BC6307_13880	COG1686	Belongs to the peptidase S11 family
BC6307_13885	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BC6307_13905	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BC6307_13910	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BC6307_13915	COG1547	Domain of unknown function (DUF309)
BC6307_13925	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BC6307_13930	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BC6307_13930	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BC6307_13935	COG0307	riboflavin synthase, alpha
BC6307_13940	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BC6307_13940	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BC6307_13945	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BC6307_13960	COG0697	spore germination
BC6307_13975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BC6307_14000	COG2172	sigma factor antagonist activity
BC6307_14010	COG1686	Belongs to the peptidase S11 family
BC6307_14030	COG4974	Belongs to the 'phage' integrase family
BC6307_14040	COG0735	belongs to the Fur family
BC6307_14045	COG1300	Membrane
BC6307_14055	COG1379	DNA repair
BC6307_14060	COG0494	nUDIX hydrolase
BC6307_14070	COG0667	Aldo Keto reductase
BC6307_14080	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BC6307_14085	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BC6307_14090	COG0183	Belongs to the thiolase family
BC6307_14095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BC6307_14100	COG1073	alpha beta
BC6307_14120	COG2223	nitrite transmembrane transporter activity
BC6307_14125	COG1882	Formate acetyltransferase
BC6307_14130	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BC6307_14140	COG2076	Multidrug Resistance protein
BC6307_14145	COG2076	Multidrug Resistance protein
BC6307_14175	COG1595	DNA-templated transcription, initiation
BC6307_14205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BC6307_14230	COG0300	oxidoreductase activity
BC6307_14235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC6307_14240	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BC6307_14260	COG1131	(ABC) transporter
BC6307_14275	COG1051	belongs to the nudix hydrolase family
BC6307_14300	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BC6307_14320	COG2824	Alkylphosphonate utilization operon protein PhnA
BC6307_14335	COG3316	Transposase and inactivated derivatives
BC6307_14345	COG1247	-acetyltransferase
BC6307_14355	COG2247	cell wall binding repeat
BC6307_14355	COG2385	sporulation resulting in formation of a cellular spore
BC6307_14360	COG4187	Peptidase family M20/M25/M40
BC6307_14365	COG1902	pentaerythritol trinitrate reductase activity
BC6307_14375	COG0346	lactoylglutathione lyase activity
BC6307_14380	COG0681	Belongs to the peptidase S26 family
BC6307_14400	COG1131	(ABC) transporter
BC6307_14410	COG2197	response regulator
BC6307_14415	COG4585	Histidine kinase
BC6307_14420	COG1234	tRNA 3'-trailer cleavage
BC6307_14430	COG0546	phosphoglycolate phosphatase activity
BC6307_14445	COG1556	Lactate utilization protein
BC6307_14450	COG1139	Iron-sulfur cluster binding protein
BC6307_14455	COG0247	lactate metabolic process
BC6307_14460	COG0277	FAD linked oxidase domain protein
BC6307_14480	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BC6307_14490	COG2195	Cleaves the N-terminal amino acid of tripeptides
BC6307_14495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BC6307_14500	COG0346	lactoylglutathione lyase activity
BC6307_14515	COG1376	ErfK ybiS ycfS ynhG family protein
BC6307_14520	COG4129	membrane
BC6307_14525	COG1164	Oligoendopeptidase f
BC6307_14535	COG1703	isobutyryl-CoA mutase activity
BC6307_14540	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BC6307_14540	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BC6307_14545	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BC6307_14555	COG0508	dehydrogenase complex catalyzes the overall conversion of
BC6307_14560	COG0022	dehydrogenase e1 component
BC6307_14565	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BC6307_14570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BC6307_14585	COG0280	phosphate acetyltransferase
BC6307_14590	COG3829	transcription factor binding
BC6307_14590	COG3290	protein histidine kinase activity
BC6307_14600	COG0584	glycerophosphoryl diester phosphodiesterase
BC6307_14605	COG3093	addiction module antidote protein HigA
BC6307_14610	COG0745	RESPONSE REGULATOR receiver
BC6307_14615	COG0750	zinc metalloprotease
BC6307_14620	COG0497	DNA recombination
BC6307_14630	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BC6307_14635	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BC6307_14655	COG1570	exodeoxyribonuclease VII activity
BC6307_14660	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BC6307_14665	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BC6307_14670	COG1302	Protein conserved in bacteria
BC6307_14675	COG0439	Biotin carboxylase
BC6307_14680	COG0511	ligase activity, forming carbon-carbon bonds
BC6307_14720	COG3854	ATPases associated with a variety of cellular activities
BC6307_14735	COG1131	(ABC) transporter
BC6307_14745	COG0366	Alpha amylase catalytic
BC6307_14755	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BC6307_14760	COG0006	proline dipeptidase activity
BC6307_14765	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BC6307_14780	COG1752	Esterase of the alpha-beta hydrolase superfamily
BC6307_14810	COG2318	DinB family
BC6307_14815	COG0697	spore germination
BC6307_14820	COG0531	amino acid
BC6307_14835	COG1309	transcriptional regulator
BC6307_14850	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BC6307_14855	COG0095	Lipoate-protein ligase
BC6307_14860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_14880	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BC6307_14885	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BC6307_14890	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BC6307_14910	COG3275	phosphorelay sensor kinase activity
BC6307_14920	COG1966	Carbon starvation protein
BC6307_14935	COG1012	belongs to the aldehyde dehydrogenase family
BC6307_14940	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_14950	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_14965	COG1272	protein, Hemolysin III
BC6307_14985	COG0793	Belongs to the peptidase S41A family
BC6307_14990	COG0456	acetyltransferase
BC6307_15030	COG2318	DinB family
BC6307_15035	COG0658	competence protein
BC6307_15035	COG2333	competence protein COMEC
BC6307_15050	COG1376	ErfK ybiS ycfS ynhG family protein
BC6307_15060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BC6307_15065	COG0697	spore germination
BC6307_15070	COG0592	DNA-directed DNA polymerase activity
BC6307_15085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BC6307_15090	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BC6307_15120	COG4970	Tfp pilus assembly protein FimT
BC6307_15125	COG4537	Required for transformation and DNA binding
BC6307_15130	COG1459	type II secretion system
BC6307_15135	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BC6307_15140	COG4191	Histidine kinase
BC6307_15170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC6307_15185	COG0011	TIGRFAM Protein of
BC6307_15200	COG1368	sulfuric ester hydrolase activity
BC6307_15205	COG1940	carbohydrate kinase activity
BC6307_15215	COG0697	spore germination
BC6307_15225	COG0705	Rhomboid family
BC6307_15225	COG0457	Tetratricopeptide repeat
BC6307_15245	COG0039	L-malate dehydrogenase activity
BC6307_15255	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BC6307_15285	COG1172	Belongs to the binding-protein-dependent transport system permease family
BC6307_15290	COG1129	ABC transporter
BC6307_15305	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BC6307_15310	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BC6307_15315	COG0640	Transcriptional regulator
BC6307_15320	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BC6307_15325	COG0659	secondary active sulfate transmembrane transporter activity
BC6307_15330	COG0704	Plays a role in the regulation of phosphate uptake
BC6307_15335	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BC6307_15340	COG0581	inorganic phosphate transmembrane transporter activity
BC6307_15345	COG0573	inorganic phosphate transmembrane transporter activity
BC6307_15350	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BC6307_15360	COG0477	Major facilitator Superfamily
BC6307_15370	COG0205	6-phosphofructokinase activity
BC6307_15380	COG2212	antiporter activity
BC6307_15385	COG1863	multisubunit Na H antiporter MnhE subunit
BC6307_15390	COG0651	ATP synthesis coupled electron transport
BC6307_15395	COG1006	Multisubunit Na H antiporter MnhC subunit
BC6307_15415	COG0582	viral genome integration into host DNA
BC6307_15440	COG2839	Protein conserved in bacteria
BC6307_15445	COG1283	sodium-dependent phosphate transmembrane transporter activity
BC6307_15450	COG5521	maltodextrose utilization protein MalA
BC6307_15460	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BC6307_15465	COG4709	membrane
BC6307_15470	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
BC6307_15475	COG0735	belongs to the Fur family
BC6307_15480	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BC6307_15485	COG1121	(ABC) transporter
BC6307_15490	COG4191	Histidine kinase
BC6307_15500	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BC6307_15515	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BC6307_15520	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BC6307_15525	COG2384	SAM-dependent methyltransferase
BC6307_15530	COG2010	Cytochrome c
BC6307_15535	COG1960	acyl-CoA dehydrogenase activity
BC6307_15545	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BC6307_15550	COG0358	DNA primase activity
BC6307_15560	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BC6307_15565	COG0517	IMP dehydrogenase activity
BC6307_15570	COG0751	glycine-tRNA ligase activity
BC6307_15580	COG1381	Involved in DNA repair and RecF pathway recombination
BC6307_15590	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BC6307_15595	COG0295	cytidine deaminase activity
BC6307_15600	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BC6307_15610	COG1480	7TM receptor with intracellular HD hydrolase
BC6307_15615	COG1702	phosphate starvation-inducible protein PhoH
BC6307_15630	COG0494	nUDIX hydrolase
BC6307_15640	COG4864	UPF0365 protein
BC6307_15645	COG1030	water channel activity
BC6307_15650	COG1610	YqeY-like protein
BC6307_15655	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BC6307_15665	COG1283	sodium-dependent phosphate transmembrane transporter activity
BC6307_15670	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BC6307_15685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BC6307_15690	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BC6307_15695	COG2264	protein methyltransferase activity
BC6307_15700	COG0484	heat shock protein binding
BC6307_15705	COG0443	Heat shock 70 kDa protein
BC6307_15710	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BC6307_15715	COG1420	regulation of RNA biosynthetic process
BC6307_15720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BC6307_15740	COG0860	N-Acetylmuramoyl-L-alanine amidase
BC6307_15755	COG1466	dna polymerase III delta subunit
BC6307_15765	COG0658	competence protein
BC6307_15765	COG2333	competence protein COMEC
BC6307_15770	COG2131	deaminase
BC6307_15775	COG1555	photosystem II stabilization
BC6307_15775	COG1596	polysaccharide export
BC6307_15780	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BC6307_15785	COG2226	methyltransferase
BC6307_15790	COG0799	negative regulation of ribosome biogenesis
BC6307_15795	COG1713	HD superfamily hydrolase involved in NAD metabolism
BC6307_15800	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BC6307_15805	COG1534	Rna-binding protein
BC6307_15815	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BC6307_15820	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BC6307_15830	COG0688	phosphatidylethanolamine metabolic process
BC6307_15840	COG1191	sigma factor activity
BC6307_15855	COG1525	nuclease
BC6307_15880	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BC6307_15885	COG1595	DNA-templated transcription, initiation
BC6307_15895	COG0626	cystathionine gamma-synthase activity
BC6307_15900	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BC6307_15905	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BC6307_15910	COG2226	methyltransferase
BC6307_15925	COG0768	penicillin binding
BC6307_15930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BC6307_15935	COG0572	uridine kinase
BC6307_15955	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BC6307_15960	COG3906	Belongs to the UPF0473 family
BC6307_15965	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BC6307_15985	COG0628	permease
BC6307_15990	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BC6307_16010	COG3881	PFAM PRC-barrel domain
BC6307_16015	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BC6307_16020	COG0457	Tetratricopeptide repeat
BC6307_16025	COG0482	sulfurtransferase activity
BC6307_16030	COG1104	cysteine desulfurase activity
BC6307_16035	COG1959	2 iron, 2 sulfur cluster binding
BC6307_16040	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BC6307_16045	COG0018	arginyl-trna synthetase
BC6307_16055	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BC6307_16070	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BC6307_16075	COG0124	histidyl-tRNA synthetase
BC6307_16085	COG3103	Sh3 type 3 domain protein
BC6307_16085	COG0860	N-Acetylmuramoyl-L-alanine amidase
BC6307_16085	COG4991	sh3 domain protein
BC6307_16090	COG1490	D-aminoacyl-tRNA deacylase activity
BC6307_16095	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BC6307_16100	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BC6307_16105	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BC6307_16105	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BC6307_16110	COG5416	Lipopolysaccharide assembly protein A domain
BC6307_16115	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BC6307_16120	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BC6307_16120	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BC6307_16130	COG2244	polysaccharide biosynthetic process
BC6307_16135	COG2323	membrane
BC6307_16145	COG1862	Preprotein translocase
BC6307_16155	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BC6307_16165	COG2255	four-way junction helicase activity
BC6307_16170	COG0632	four-way junction helicase activity
BC6307_16185	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BC6307_16205	COG0157	Belongs to the NadC ModD family
BC6307_16210	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BC6307_16215	COG1104	cysteine desulfurase activity
BC6307_16220	COG1827	regulation of RNA biosynthetic process
BC6307_16240	COG4492	Belongs to the UPF0735 family
BC6307_16250	COG3290	protein histidine kinase activity
BC6307_16260	COG2868	ribosomal protein
BC6307_16265	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BC6307_16270	COG1530	ribonuclease E activity
BC6307_16275	COG1994	Peptidase M50
BC6307_16280	COG0739	heme binding
BC6307_16285	COG2894	cell division
BC6307_16290	COG0850	regulation of cytokinetic process
BC6307_16295	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BC6307_16300	COG1792	Involved in formation and maintenance of cell shape
BC6307_16305	COG1077	Cell shape determining protein MreB Mrl
BC6307_16310	COG2003	Belongs to the UPF0758 family
BC6307_16340	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BC6307_16385	COG3706	GGDEF domain
BC6307_16390	COG0285	dihydrofolate synthase activity
BC6307_16395	COG0525	valine-tRNA ligase activity
BC6307_16410	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BC6307_16415	COG1388	LysM domain
BC6307_16415	COG1388	LysM domain
BC6307_16425	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BC6307_16430	COG0113	porphobilinogen synthase activity
BC6307_16435	COG1587	Uroporphyrinogen-III synthase
BC6307_16440	COG0181	hydroxymethylbilane synthase activity
BC6307_16445	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BC6307_16475	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BC6307_16480	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BC6307_16485	COG0470	DNA polymerase III
BC6307_16485	COG1067	ATP-dependent peptidase activity
BC6307_16490	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BC6307_16495	COG0544	peptidyl-prolyl cis-trans isomerase activity
BC6307_16500	COG1477	protein flavinylation
BC6307_16500	COG0457	Tetratricopeptide repeat
BC6307_16510	COG0622	Phosphoesterase
BC6307_16515	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BC6307_16525	COG5401	PFAM Sporulation and spore germination
BC6307_16535	COG1846	Transcriptional regulator
BC6307_16540	COG2197	response regulator
BC6307_16545	COG0824	Thioesterase
BC6307_16550	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BC6307_16555	COG1053	succinate dehydrogenase
BC6307_16560	COG2009	succinate dehydrogenase
BC6307_16565	COG1719	4-vinyl reductase, 4VR
BC6307_16575	COG0322	excinuclease ABC activity
BC6307_16580	COG3118	belongs to the thioredoxin family
BC6307_16585	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BC6307_16590	COG2086	electron transfer activity
BC6307_16595	COG1024	Enoyl-CoA hydratase
BC6307_16600	COG1309	transcriptional regulator
BC6307_16605	COG0318	PFAM AMP-dependent synthetase and ligase
BC6307_16610	COG3766	membrane
BC6307_16615	COG1193	negative regulation of DNA recombination
BC6307_16620	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BC6307_16620	COG1796	DNA polymerase
BC6307_16625	COG1286	toxin biosynthetic process
BC6307_16630	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BC6307_16635	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BC6307_16650	COG0072	phenylalanine-tRNA ligase activity
BC6307_16650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BC6307_16670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BC6307_16680	COG1363	Peptidase, m42
BC6307_16705	COG0398	Pfam SNARE associated Golgi protein
BC6307_16710	COG3326	Membrane
BC6307_16715	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BC6307_16720	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BC6307_16725	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BC6307_16730	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BC6307_16740	COG3611	Membrane attachment protein
BC6307_16745	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BC6307_16755	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BC6307_16760	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BC6307_16770	COG1971	Probably functions as a manganese efflux pump
BC6307_16775	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BC6307_16780	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BC6307_16780	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BC6307_16785	COG0330	HflC and HflK could
BC6307_16790	COG0330	HflC and HflK could
BC6307_16795	COG5002	protein histidine kinase activity
BC6307_16800	COG0745	RESPONSE REGULATOR receiver
BC6307_16810	COG0039	L-malate dehydrogenase activity
BC6307_16815	COG0538	isocitrate dehydrogenase activity
BC6307_16820	COG0372	Belongs to the citrate synthase family
BC6307_16825	COG2707	UPF0756 membrane protein
BC6307_16830	COG0628	permease
BC6307_16835	COG3030	protein affecting phage T7 exclusion by the F plasmid
BC6307_16845	COG0205	6-phosphofructokinase activity
BC6307_16850	COG0825	malonyl-CoA metabolic process
BC6307_16860	COG1725	Transcriptional regulator
BC6307_16865	COG0281	malic enzyme
BC6307_16870	COG0587	DNA-directed DNA polymerase activity
BC6307_16885	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BC6307_16895	COG4109	DRTGG domain
BC6307_16905	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BC6307_16910	COG0006	proline dipeptidase activity
BC6307_16915	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_16920	COG0589	response to stress
BC6307_16940	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BC6307_16945	COG0827	DNA restriction-modification system
BC6307_16950	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BC6307_16955	COG3874	Sporulation protein YtfJ
BC6307_16965	COG1714	RDD family
BC6307_16970	COG0616	signal peptide processing
BC6307_16975	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BC6307_16980	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BC6307_16990	COG0301	tRNA thio-modification
BC6307_16995	COG1104	cysteine desulfurase activity
BC6307_17000	COG1114	Component of the transport system for branched-chain amino acids
BC6307_17005	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BC6307_17010	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BC6307_17015	COG1309	transcriptional regulator
BC6307_17020	COG1956	GAF domain-containing protein
BC6307_17025	COG0626	cystathionine gamma-synthase activity
BC6307_17030	COG2199	diguanylate cyclase activity
BC6307_17030	COG2203	Gaf domain
BC6307_17040	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BC6307_17045	COG2207	Transcriptional regulator
BC6307_17050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BC6307_17050	COG2190	(PTS) system
BC6307_17050	COG1263	PTS System
BC6307_17070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BC6307_17075	COG0454	-acetyltransferase
BC6307_17080	COG0517	IMP dehydrogenase activity
BC6307_17085	COG0123	including yeast histone deacetylase and acetoin utilization protein
BC6307_17095	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BC6307_17105	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BC6307_17105	COG1605	Chorismate mutase
BC6307_17110	COG4980	gas vesicle protein
BC6307_17125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BC6307_17135	COG1674	ftsk spoiiie
BC6307_17140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BC6307_17145	COG4848	Belongs to the UPF0354 family
BC6307_17150	COG1404	Belongs to the peptidase S8 family
BC6307_17150	COG4412	M6 family metalloprotease domain protein
BC6307_17155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BC6307_17165	COG0840	transmembrane signaling receptor activity
BC6307_17185	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
BC6307_17190	COG1363	Peptidase, m42
BC6307_17195	COG5584	Small secreted protein
BC6307_17200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC6307_17205	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BC6307_17215	COG0510	thiamine kinase activity
BC6307_17220	COG1523	belongs to the glycosyl hydrolase 13 family
BC6307_17230	COG1346	cytolysis
BC6307_17235	COG1380	Effector of murein hydrolase LrgA
BC6307_17245	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BC6307_17255	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BC6307_17260	COG1472	Belongs to the glycosyl hydrolase 3 family
BC6307_17265	COG3876	Protein conserved in bacteria
BC6307_17275	COG3842	ATPase activity
BC6307_17280	COG0395	ABC-type sugar transport system, permease component
BC6307_17285	COG1175	transmembrane transport
BC6307_17295	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BC6307_17310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BC6307_17320	COG1131	(ABC) transporter
BC6307_17325	COG1349	DNA-binding transcription factor activity
BC6307_17330	COG1187	pseudouridine synthase activity
BC6307_17340	COG2244	polysaccharide biosynthetic process
BC6307_17350	COG2081	HI0933 family
BC6307_17365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_17370	COG0495	leucyl-tRNA aminoacylation
BC6307_17380	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_17385	COG2610	gluconate transmembrane transporter activity
BC6307_17400	COG2814	Major facilitator Superfamily
BC6307_17415	COG1242	4 iron, 4 sulfur cluster binding
BC6307_17420	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BC6307_17430	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BC6307_17440	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BC6307_17445	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BC6307_17455	COG2267	carboxylic ester hydrolase activity
BC6307_17460	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BC6307_17470	COG0438	transferase activity, transferring glycosyl groups
BC6307_17475	COG0217	transcriptional regulatory protein
BC6307_17480	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BC6307_17490	COG1506	peptidase
BC6307_17495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BC6307_17500	COG1116	anion transmembrane transporter activity
BC6307_17505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BC6307_17510	COG0494	nUDIX hydrolase
BC6307_17525	COG0783	Belongs to the Dps family
BC6307_17540	COG0701	Predicted permease
BC6307_17545	COG1854	S-ribosylhomocysteine lyase activity
BC6307_17550	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BC6307_17555	COG0288	reversible hydration of carbon dioxide
BC6307_17560	COG0523	cobalamin synthesis protein
BC6307_17575	COG0523	cobalamin synthesis protein
BC6307_17585	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BC6307_17590	COG1321	iron dependent repressor
BC6307_17590	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BC6307_17595	COG1121	(ABC) transporter
BC6307_17600	COG0803	Belongs to the bacterial solute-binding protein 9 family
BC6307_17605	COG0318	PFAM AMP-dependent synthetase and ligase
BC6307_17610	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BC6307_17615	COG0596	Alpha beta hydrolase
BC6307_17620	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BC6307_17625	COG1169	isochorismate synthase
BC6307_17630	COG1575	Belongs to the MenA family. Type 1 subfamily
BC6307_17635	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BC6307_17645	COG0058	SHG alpha-glucan phosphorylase activity
BC6307_17650	COG0297	glycogen (starch) synthase activity
BC6307_17655	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BC6307_17815	COG1285	pathogenesis
BC6307_17865	COG0860	N-Acetylmuramoyl-L-alanine amidase
BC6307_18000	COG5484	DNA packaging
BC6307_18015	COG3677	Transposase
BC6307_18050	COG2201	protein-glutamate methylesterase activity
BC6307_18075	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
BC6307_18090	COG1484	DNA-dependent DNA replication
BC6307_18170	COG1396	sequence-specific DNA binding
BC6307_18200	COG2223	nitrite transmembrane transporter activity
BC6307_18210	COG0243	molybdopterin cofactor binding
BC6307_18215	COG0437	4 iron, 4 sulfur cluster binding
BC6307_18220	COG0723	plastoquinol--plastocyanin reductase activity
BC6307_18235	COG0489	protein tyrosine kinase activity
BC6307_18245	COG1366	Belongs to the anti-sigma-factor antagonist family
BC6307_18260	COG1280	lysine exporter protein (LysE YggA)
BC6307_18275	COG1113	amino acid transport
BC6307_18280	COG1280	lysine exporter protein (LysE YggA)
BC6307_18300	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BC6307_18305	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BC6307_18320	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BC6307_18325	COG0673	inositol 2-dehydrogenase activity
BC6307_18340	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_18355	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BC6307_18375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BC6307_18375	COG2111	Na H antiporter
BC6307_18380	COG2111	Na H antiporter
BC6307_18385	COG1006	Multisubunit Na H antiporter MnhC subunit
BC6307_18390	COG0651	ATP synthesis coupled electron transport
BC6307_18400	COG2212	antiporter activity
BC6307_18405	COG1320	monovalent cation:proton antiporter activity
BC6307_18410	COG1979	alcohol dehydrogenase
BC6307_18415	COG2155	Conserved Protein
BC6307_18420	COG1098	S1 RNA binding domain
BC6307_18425	COG2267	carboxylic ester hydrolase activity
BC6307_18435	COG3316	Transposase and inactivated derivatives
BC6307_18440	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BC6307_18450	COG2032	superoxide dismutase activity
BC6307_18460	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BC6307_18470	COG5018	Exonuclease
BC6307_18475	COG2814	Major facilitator Superfamily
BC6307_18485	COG2050	protein possibly involved in aromatic compounds catabolism
BC6307_18510	COG1595	DNA-templated transcription, initiation
BC6307_18520	COG4555	ABC transporter
BC6307_18525	COG0772	Belongs to the SEDS family
BC6307_18530	COG0772	Belongs to the SEDS family
BC6307_18540	COG1268	BioY protein
BC6307_18545	COG2056	Na+-H+ antiporter family
BC6307_18560	COG0697	spore germination
BC6307_18565	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BC6307_18575	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BC6307_18580	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BC6307_18585	COG3584	3D domain protein
BC6307_18600	COG1252	NADH dehydrogenase
BC6307_18615	COG0316	Belongs to the HesB IscA family
BC6307_18620	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BC6307_18625	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BC6307_18635	COG1252	NADH dehydrogenase
BC6307_18640	COG4837	Protein of unknown function (DUF1462)
BC6307_18645	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BC6307_18650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BC6307_18655	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BC6307_18660	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BC6307_18665	COG0647	UMP catabolic process
BC6307_18670	COG2445	Protein of unknown function DUF86
BC6307_18685	COG4470	Protein conserved in bacteria
BC6307_18700	COG0527	aspartate kinase activity
BC6307_18710	COG0739	heme binding
BC6307_18720	COG0733	neurotransmitter:sodium symporter activity
BC6307_18725	COG1757	Na H antiporter
BC6307_18740	COG3377	Domain of unknown function (DUF1805)
BC6307_18745	COG0737	Belongs to the 5'-nucleotidase family
BC6307_18750	COG0730	response to heat
BC6307_18755	COG1801	Protein of unknown function DUF72
BC6307_18770	COG0719	Fe-S assembly protein
BC6307_18775	COG0822	iron-sulfur transferase activity
BC6307_18780	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BC6307_18785	COG0719	Fe-S assembly protein
BC6307_18790	COG0396	ATPase activity
BC6307_18795	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BC6307_18800	COG1464	Belongs to the NlpA lipoprotein family
BC6307_18805	COG2011	ABC-type metal ion transport system permease component
BC6307_18810	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BC6307_18820	COG2814	Major facilitator Superfamily
BC6307_18825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BC6307_18830	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BC6307_18850	COG0509	glycine decarboxylation via glycine cleavage system
BC6307_18855	COG1393	Belongs to the ArsC family
BC6307_18860	COG1960	acyl-CoA dehydrogenase activity
BC6307_18865	COG0183	Belongs to the thiolase family
BC6307_18870	COG1250	3-hydroxyacyl-CoA dehydrogenase
BC6307_18870	COG1024	Enoyl-CoA hydratase
BC6307_18890	COG5577	PFAM Coat F domain
BC6307_18905	COG1120	ATPase activity
BC6307_18910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BC6307_18915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BC6307_18920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BC6307_18925	COG0584	glycerophosphoryl diester phosphodiesterase
BC6307_18930	COG0737	Belongs to the 5'-nucleotidase family
BC6307_18940	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_18945	COG0750	zinc metalloprotease
BC6307_18965	COG1595	DNA-templated transcription, initiation
BC6307_18970	COG0425	Belongs to the sulfur carrier protein TusA family
BC6307_18970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_18980	COG2210	Belongs to the sulfur carrier protein TusA family
BC6307_18985	COG0425	Belongs to the sulfur carrier protein TusA family
BC6307_18990	COG1937	Protein conserved in bacteria
BC6307_18995	COG0726	polysaccharide deacetylase
BC6307_19000	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BC6307_19005	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BC6307_19015	COG1063	alcohol dehydrogenase
BC6307_19030	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BC6307_19030	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BC6307_19060	COG3344	reverse transcriptase
BC6307_19140	COG1131	(ABC) transporter
BC6307_19195	COG0210	DNA helicase
BC6307_19200	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BC6307_19210	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BC6307_19215	COG0557	exoribonuclease II activity
BC6307_19220	COG1647	Serine aminopeptidase, S33
BC6307_19230	COG1396	sequence-specific DNA binding
BC6307_19240	COG0681	Belongs to the peptidase S26 family
BC6307_19265	COG5002	protein histidine kinase activity
BC6307_19270	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BC6307_19280	COG0148	phosphopyruvate hydratase activity
BC6307_19290	COG0149	triose-phosphate isomerase activity
BC6307_19300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BC6307_19315	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BC6307_19445	COG0740	serine-type endopeptidase activity
BC6307_19455	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BC6307_19460	COG1481	regulation of sporulation
BC6307_19465	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BC6307_19470	COG1660	Displays ATPase and GTPase activities
BC6307_19475	COG1051	belongs to the nudix hydrolase family
BC6307_19480	COG0492	ferredoxin-NADP+ reductase activity
BC6307_19485	COG0457	Tetratricopeptide repeat
BC6307_19490	COG0140	phosphoribosyl-ATP diphosphatase activity
BC6307_19490	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BC6307_19495	COG0107	imidazoleglycerol-phosphate synthase activity
BC6307_19500	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BC6307_19505	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BC6307_19510	COG0131	Imidazoleglycerol-phosphate dehydratase
BC6307_19515	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BC6307_19525	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BC6307_19530	COG0110	maltose O-acetyltransferase activity
BC6307_19540	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BC6307_19550	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BC6307_19555	COG1950	PFAM Membrane protein of
BC6307_19560	COG1983	PspC domain protein
BC6307_19565	COG3595	metallopeptidase activity
BC6307_19580	COG0840	transmembrane signaling receptor activity
BC6307_19585	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BC6307_19590	COG0556	nucleotide-excision repair
BC6307_19605	COG1595	DNA-templated transcription, initiation
BC6307_19610	COG4897	Protein conserved in bacteria
BC6307_19620	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BC6307_19635	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BC6307_19640	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BC6307_19645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BC6307_19650	COG3409	Peptidoglycan-binding domain 1 protein
BC6307_19650	COG0793	Belongs to the peptidase S41A family
BC6307_19655	COG0739	heme binding
BC6307_19660	COG2177	Part of the ABC transporter FtsEX involved in
BC6307_19665	COG2884	Cell division ATP-binding protein ftsE
BC6307_19675	COG1404	Belongs to the peptidase S8 family
BC6307_19685	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BC6307_19695	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BC6307_19700	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BC6307_19705	COG0653	protein targeting
BC6307_19715	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BC6307_19735	COG1516	flagellar protein fliS
BC6307_19740	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BC6307_19755	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BC6307_19765	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BC6307_19775	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BC6307_19780	COG4786	Flagellar basal body rod
BC6307_19780	COG1256	bacterial-type flagellum assembly
BC6307_19800	COG1040	competence protein
BC6307_19805	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BC6307_19810	COG1307	EDD domain protein, DegV family
BC6307_19830	COG2197	response regulator
BC6307_19835	COG4585	Histidine kinase
BC6307_19840	COG1739	Uncharacterized protein family UPF0029
BC6307_19845	COG1316	TRANSCRIPTIONal
BC6307_19850	COG0438	transferase activity, transferring glycosyl groups
BC6307_19855	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BC6307_19860	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BC6307_19880	COG4464	protein tyrosine phosphatase activity
BC6307_19885	COG3764	Sortase (surface protein transpeptidase)
BC6307_19900	COG4715	Zinc finger, swim domain protein
BC6307_19905	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BC6307_19920	COG0629	single-stranded DNA binding
BC6307_19930	COG3764	Sortase (surface protein transpeptidase)
BC6307_19950	COG1227	inorganic diphosphatase activity
BC6307_19955	COG1215	transferase activity, transferring glycosyl groups
BC6307_19965	COG4193	domain, Protein
BC6307_19970	COG0463	Glycosyl transferase, family 2
BC6307_19985	COG2247	cell wall binding repeat
BC6307_19985	COG0860	N-Acetylmuramoyl-L-alanine amidase
BC6307_19990	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BC6307_19990	COG2755	lipolytic protein G-D-S-L family
BC6307_20005	COG1215	transferase activity, transferring glycosyl groups
BC6307_20010	COG0438	transferase activity, transferring glycosyl groups
BC6307_20015	COG1653	transport
BC6307_20020	COG0395	ABC-type sugar transport system, permease component
BC6307_20025	COG1175	transmembrane transport
BC6307_20035	COG1316	TRANSCRIPTIONal
BC6307_20040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BC6307_20075	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BC6307_20085	COG1464	Belongs to the NlpA lipoprotein family
BC6307_20090	COG0371	Dehydrogenase
BC6307_20095	COG2031	fatty acid transporter
BC6307_20100	COG2962	Rard protein
BC6307_20125	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BC6307_20155	COG2972	Histidine kinase
BC6307_20200	COG1404	Belongs to the peptidase S8 family
BC6307_20205	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BC6307_20210	COG0673	inositol 2-dehydrogenase activity
BC6307_20225	COG1653	transport
BC6307_20230	COG4753	response regulator
BC6307_20230	COG2207	Transcriptional regulator
BC6307_20245	COG0395	ABC-type sugar transport system, permease component
BC6307_20250	COG1175	transmembrane transport
BC6307_20255	COG1653	transport
BC6307_20420	COG1505	serine-type exopeptidase activity
BC6307_20435	COG4213	ABC transporter substrate-binding protein
BC6307_20440	COG2207	Transcriptional regulator
BC6307_20440	COG4753	response regulator
BC6307_20445	COG2972	Histidine kinase
BC6307_20455	COG4214	carbohydrate transport
BC6307_20465	COG4213	ABC transporter substrate-binding protein
BC6307_20520	COG2706	6-phosphogluconolactonase activity
BC6307_20525	COG1301	dicarboxylic acid transport
BC6307_20575	COG0561	phosphatase activity
BC6307_20590	COG1063	alcohol dehydrogenase
BC6307_20595	COG1172	Belongs to the binding-protein-dependent transport system permease family
BC6307_20600	COG1129	ABC transporter
BC6307_20605	COG1879	ABC-type sugar transport system periplasmic component
BC6307_20625	COG1473	amidohydrolase
BC6307_20645	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BC6307_20655	COG1028	Short-chain dehydrogenase reductase Sdr
BC6307_20660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BC6307_20720	COG1131	(ABC) transporter
BC6307_20735	COG1757	Na H antiporter
BC6307_20790	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BC6307_20795	COG1072	(Pantothenic acid kinase))
BC6307_20805	COG2801	Transposase and inactivated derivatives
BC6307_20815	COG5583	Uncharacterized small protein (DUF2292)
BC6307_20820	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BC6307_20830	COG3973	AAA domain
BC6307_20840	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BC6307_20865	COG0561	phosphatase activity
BC6307_20945	COG0457	Tetratricopeptide repeat
BC6307_20945	COG0463	Glycosyl transferase, family 2
BC6307_20975	COG2814	Major facilitator Superfamily
BC6307_21005	COG5002	protein histidine kinase activity
BC6307_21010	COG0745	RESPONSE REGULATOR receiver
BC6307_21015	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BC6307_21020	COG1131	(ABC) transporter
BC6307_21030	COG1505	serine-type exopeptidase activity
BC6307_21100	COG1078	dGTPase activity
BC6307_21105	COG2252	PERMEase
BC6307_21115	COG0606	chelatase, subunit chli
BC6307_21135	COG0471	metal ion transport
BC6307_21135	COG3273	potassium ion transport
BC6307_21140	COG5001	Diguanylate cyclase
BC6307_21140	COG3300	MHYT domain
BC6307_21145	COG0492	ferredoxin-NADP+ reductase activity
BC6307_21150	COG0492	ferredoxin-NADP+ reductase activity
BC6307_21165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BC6307_21170	COG0785	Cytochrome C biogenesis protein
BC6307_21180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_21200	COG0425	Belongs to the sulfur carrier protein TusA family
BC6307_21205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_21205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC6307_21220	COG0425	Belongs to the sulfur carrier protein TusA family
BC6307_21220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_21240	COG1937	Protein conserved in bacteria
BC6307_21250	COG0730	response to heat
BC6307_21255	COG0425	Belongs to the sulfur carrier protein TusA family
BC6307_21260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_21260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC6307_21270	COG2210	Belongs to the sulfur carrier protein TusA family
BC6307_21275	COG0425	Belongs to the sulfur carrier protein TusA family
BC6307_21275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_21280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC6307_21305	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BC6307_21315	COG5444	nuclease activity
BC6307_21350	COG2801	Transposase and inactivated derivatives
BC6307_21360	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BC6307_21365	COG0728	peptidoglycan biosynthetic process
BC6307_21375	COG0438	transferase activity, transferring glycosyl groups
BC6307_21405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BC6307_21405	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BC6307_21425	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BC6307_21435	COG1086	Polysaccharide biosynthesis protein
BC6307_21440	COG0489	protein tyrosine kinase activity
BC6307_21445	COG3944	biosynthesis protein
BC6307_21490	COG4786	Flagellar basal body rod
BC6307_21505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BC6307_21510	COG0765	amino acid transport
BC6307_21515	COG1126	abc transporter atp-binding protein
BC6307_21535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BC6307_21540	COG2323	membrane
BC6307_21550	COG2197	response regulator
BC6307_21555	COG4585	Histidine kinase
BC6307_21560	COG3239	Fatty acid desaturase
BC6307_21570	COG1511	domain protein
BC6307_21575	COG1309	transcriptional regulator
BC6307_21580	COG0702	epimerase
BC6307_21585	COG1393	Belongs to the ArsC family
BC6307_21610	COG2226	methyltransferase
BC6307_21615	COG1476	TRANSCRIPTIONal
BC6307_21625	COG2723	6-phospho-beta-galactosidase activity
BC6307_21635	COG1077	Cell shape determining protein MreB Mrl
BC6307_21640	COG1609	Transcriptional regulator
BC6307_21655	COG0604	alcohol dehydrogenase
BC6307_21735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BC6307_21745	COG0456	acetyltransferase
BC6307_21765	COG2153	protein acetylation
BC6307_21775	COG5002	protein histidine kinase activity
BC6307_21775	COG2176	DNA-directed DNA polymerase activity
BC6307_21790	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BC6307_21810	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BC6307_21815	COG2059	Chromate
BC6307_21820	COG2059	Chromate
BC6307_21830	COG0405	Gamma-glutamyltransferase
BC6307_21835	COG3852	Histidine kinase
BC6307_21840	COG3852	Histidine kinase
BC6307_21845	COG0739	heme binding
BC6307_21865	COG2385	sporulation resulting in formation of a cellular spore
BC6307_21870	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BC6307_21880	COG4836	Membrane
BC6307_21885	COG1007	ATP synthesis coupled electron transport
BC6307_21895	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BC6307_21900	COG0713	ATP synthesis coupled electron transport
BC6307_21905	COG0839	Belongs to the complex I subunit 6 family
BC6307_21910	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BC6307_21915	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BC6307_21925	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BC6307_21930	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BC6307_21940	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BC6307_21945	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BC6307_21950	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BC6307_21955	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BC6307_21960	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BC6307_21965	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BC6307_21970	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BC6307_21975	COG0356	it plays a direct role in the translocation of protons across the membrane
BC6307_21990	COG1404	Belongs to the peptidase S8 family
BC6307_22000	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BC6307_22015	COG1595	DNA-templated transcription, initiation
BC6307_22025	COG0698	ribose 5-phosphate isomerase
BC6307_22030	COG0840	transmembrane signaling receptor activity
BC6307_22030	COG5278	phosphoserine phosphatase activity
BC6307_22035	COG0840	transmembrane signaling receptor activity
BC6307_22045	COG1971	Probably functions as a manganese efflux pump
BC6307_22050	COG0009	L-threonylcarbamoyladenylate synthase
BC6307_22065	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BC6307_22080	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BC6307_22100	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BC6307_22110	COG0697	spore germination
BC6307_22115	COG1435	thymidine kinase activity
BC6307_22130	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BC6307_22135	COG1494	fructose-1,6-bisphosphatase
BC6307_22140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BC6307_22145	COG0191	fructose-bisphosphate aldolase activity
BC6307_22150	COG2204	response regulator
BC6307_22155	COG4821	SIS domain
BC6307_22160	COG0504	CTP synthase activity
BC6307_22165	COG3343	RNA polymerase activity
BC6307_22170	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BC6307_22170	COG1703	isobutyryl-CoA mutase activity
BC6307_22170	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BC6307_22175	COG3226	Transcriptional regulator
BC6307_22180	COG1960	acyl-CoA dehydrogenase activity
BC6307_22185	COG1960	acyl-CoA dehydrogenase activity
BC6307_22190	COG1250	3-hydroxyacyl-CoA dehydrogenase
BC6307_22200	COG0183	Belongs to the thiolase family
BC6307_22205	COG2181	nitrate reductase activity
BC6307_22205	COG0247	lactate metabolic process
BC6307_22210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BC6307_22225	COG1595	DNA-templated transcription, initiation
BC6307_22245	COG0675	Transposase, IS605 OrfB family
BC6307_22250	COG0010	Belongs to the arginase family
BC6307_22255	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BC6307_22260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BC6307_22270	COG1994	Peptidase M50
BC6307_22280	COG0456	acetyltransferase
BC6307_22285	COG4325	translation initiation factor activity
BC6307_22290	COG3465	dGTPase activity
BC6307_22295	COG1078	dGTPase activity
BC6307_22315	COG0095	Lipoate-protein ligase
BC6307_22320	COG0280	phosphate acetyltransferase
BC6307_22335	COG2363	Small membrane protein
BC6307_22340	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BC6307_22350	COG1984	allophanate hydrolase subunit 2
BC6307_22365	COG2322	membrane
BC6307_22390	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BC6307_22395	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BC6307_22415	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BC6307_22425	COG0501	Belongs to the peptidase M48B family
BC6307_22440	COG0778	Nitroreductase
BC6307_22450	COG2031	fatty acid transporter
BC6307_22455	COG0561	phosphatase activity
BC6307_22500	COG0551	DNA topoisomerase type I activity
BC6307_22500	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BC6307_22505	COG0488	(ABC) transporter
BC6307_22530	COG1595	DNA-templated transcription, initiation
BC6307_22550	COG3842	ATPase activity
BC6307_22560	COG1840	ABC-type Fe3 transport system, periplasmic component
BC6307_22565	COG1794	racemase activity, acting on amino acids and derivatives
BC6307_22575	COG0367	asparagine synthase
BC6307_22580	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BC6307_22585	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BC6307_22590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BC6307_22605	COG4187	Peptidase family M20/M25/M40
BC6307_22625	COG1744	ABC transporter substrate-binding protein PnrA-like
BC6307_22630	COG1959	2 iron, 2 sulfur cluster binding
BC6307_22640	COG2814	Major facilitator Superfamily
BC6307_22655	COG1187	pseudouridine synthase activity
BC6307_22660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BC6307_22675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BC6307_22685	COG4608	Belongs to the ABC transporter superfamily
BC6307_22690	COG0444	Belongs to the ABC transporter superfamily
BC6307_22705	COG0747	negative chemotaxis
BC6307_22720	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BC6307_22725	COG0561	phosphatase activity
BC6307_22730	COG0798	PFAM Bile acid sodium symporter
BC6307_22745	COG1279	arginine transmembrane transporter activity
BC6307_22760	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BC6307_22780	COG4191	Histidine kinase
BC6307_22785	COG1966	Carbon starvation protein
BC6307_22815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BC6307_22820	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BC6307_22830	COG4863	YycH protein
BC6307_22835	COG5002	protein histidine kinase activity
BC6307_22840	COG0745	RESPONSE REGULATOR receiver
BC6307_22845	COG1196	nuclear chromosome segregation
BC6307_22845	COG0741	lytic transglycosylase activity
BC6307_22845	COG0739	heme binding
BC6307_22875	COG0305	Participates in initiation and elongation during chromosome replication
BC6307_22880	COG0359	binds to the 23S rRNA
BC6307_22885	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BC6307_22895	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BC6307_22905	COG0360	Binds together with S18 to 16S ribosomal RNA
BC6307_22910	COG0012	GTP binding
BC6307_22915	COG4481	Protein conserved in bacteria
BC6307_22920	COG3949	Membrane
BC6307_22935	COG1475	DNA binding
BC6307_22940	COG1192	Involved in chromosome partitioning
BC6307_22945	COG1475	DNA binding
BC6307_22950	COG0357	Ribosomal RNA small subunit methyltransferase G
BC6307_22955	COG0445	tRNA wobble uridine modification
BC6307_22960	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BC6307_22965	COG1847	R3H domain protein
BC6307_22980	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BC6307_22985	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BC6307_22990	COG0592	DNA-directed DNA polymerase activity
BC6307_22995	COG2501	S4 domain
BC6307_23000	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BC6307_23010	COG0187	DNA topoisomerase II activity
BC6307_23015	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BC6307_23020	COG2199	diguanylate cyclase activity
BC6307_23020	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BC6307_23060	COG0516	GMP reductase activity
BC6307_23060	COG0517	IMP dehydrogenase activity
BC6307_23070	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BC6307_23075	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BC6307_23080	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BC6307_23090	COG1428	Deoxynucleoside kinase
BC6307_23095	COG1428	Deoxynucleoside kinase
BC6307_23100	COG1335	isochorismatase
BC6307_23105	COG0590	tRNA wobble adenosine to inosine editing
BC6307_23115	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BC6307_23120	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BC6307_23170	COG1982	Orn Lys Arg decarboxylase major
BC6307_23175	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BC6307_23180	COG3870	Protein conserved in bacteria
BC6307_23185	COG1728	Protein conserved in bacteria
BC6307_23190	COG0470	DNA polymerase III
BC6307_23195	COG1774	PSP1 C-terminal conserved region
BC6307_23200	COG4467	Involved in initiation control of chromosome replication
BC6307_23205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BC6307_23210	COG2827	Endonuclease containing a URI domain
BC6307_23215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BC6307_23220	COG2002	toxin-antitoxin pair type II binding
BC6307_23230	COG0084	hydrolase, TatD family'
BC6307_23235	COG3583	domain protein
BC6307_23235	COG3584	3D domain protein
BC6307_23240	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BC6307_23245	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BC6307_23255	COG4466	Protein conserved in bacteria
BC6307_23265	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BC6307_23270	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BC6307_23275	COG0251	oxidation-reduction process
BC6307_23285	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BC6307_23290	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BC6307_23295	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BC6307_23300	COG0193	aminoacyl-tRNA hydrolase activity
BC6307_23310	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BC6307_23315	COG2002	toxin-antitoxin pair type II binding
BC6307_23320	COG2244	polysaccharide biosynthetic process
BC6307_23325	COG3956	TIGRFAM MazG family protein
BC6307_23330	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BC6307_23350	COG1098	S1 RNA binding domain
BC6307_23365	COG2208	phosphoserine phosphatase activity
BC6307_23370	COG2304	oxidoreductase activity
BC6307_23375	COG0515	serine threonine protein kinase
BC6307_23390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BC6307_23395	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BC6307_23400	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BC6307_23405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BC6307_23410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BC6307_23415	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BC6307_23420	COG0512	Glutamine amidotransferase of anthranilate synthase
BC6307_23425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BC6307_23430	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BC6307_23435	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BC6307_23440	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BC6307_23445	COG1396	sequence-specific DNA binding
BC6307_23450	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BC6307_23540	COG3880	PFAM UvrB UvrC protein
BC6307_23545	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BC6307_23550	COG0542	response to heat
BC6307_23555	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BC6307_23565	COG4956	integral membrane protein (PIN domain superfamily)
BC6307_23570	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BC6307_23575	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BC6307_23580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BC6307_23585	COG1045	serine acetyltransferase
BC6307_23590	COG0215	cysteine-tRNA ligase activity
BC6307_23600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BC6307_23605	COG3688	RNA-binding protein containing a PIN domain
BC6307_23615	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BC6307_23620	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BC6307_23625	COG0250	Participates in transcription elongation, termination and antitermination
BC6307_23635	COG0081	regulation of translation
BC6307_23640	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BC6307_23650	COG2813	Specifically methylates the guanine in position
BC6307_23655	COG0085	RNA polymerase activity
BC6307_23665	COG1358	cellular component organization or biogenesis
BC6307_23670	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BC6307_23680	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BC6307_23685	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BC6307_23690	COG0051	transcription antitermination factor activity, RNA binding
BC6307_23695	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BC6307_23700	COG0088	Forms part of the polypeptide exit tunnel
BC6307_23705	COG0089	rRNA binding
BC6307_23710	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BC6307_23715	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BC6307_23720	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BC6307_23725	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BC6307_23730	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BC6307_23735	COG0255	Belongs to the universal ribosomal protein uL29 family
BC6307_23740	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BC6307_23745	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BC6307_23750	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BC6307_23755	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BC6307_23760	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BC6307_23765	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BC6307_23770	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BC6307_23775	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BC6307_23780	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BC6307_23785	COG1841	ribosomal large subunit assembly
BC6307_23790	COG0200	Binds to the 23S rRNA
BC6307_23795	COG0201	protein transport
BC6307_23800	COG0563	adenylate kinase activity
BC6307_23805	COG0024	Methionine aminopeptidase
BC6307_23810	COG2163	COG2163 Ribosomal protein L14E L6E L27E
BC6307_23815	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BC6307_23820	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BC6307_23825	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BC6307_23830	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BC6307_23835	COG0202	RNA polymerase activity
BC6307_23840	COG0203	ribosomal protein L17
BC6307_23845	COG1122	ATPase activity
BC6307_23850	COG1122	ATPase activity
BC6307_23855	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BC6307_23860	COG0101	tRNA pseudouridine synthase activity
BC6307_23865	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BC6307_23870	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BC6307_23875	COG1216	Glycosyl transferase, family 2
BC6307_23880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BC6307_23885	COG0655	NAD(P)H dehydrogenase (quinone) activity
BC6307_23900	COG0860	N-Acetylmuramoyl-L-alanine amidase
BC6307_23905	COG0489	protein tyrosine kinase activity
BC6307_23915	COG2194	sulfuric ester hydrolase activity
BC6307_23920	COG0726	polysaccharide deacetylase
BC6307_23990	COG1595	DNA-templated transcription, initiation
BC6307_23995	COG5662	AntiSigma factor
BC6307_24000	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BC6307_24005	COG4856	YbbR-like protein
BC6307_24010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BC6307_24015	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BC6307_24020	COG0402	S-adenosylhomocysteine deaminase activity
BC6307_24035	COG0318	PFAM AMP-dependent synthetase and ligase
BC6307_24045	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BC6307_24050	COG0432	Pfam Uncharacterised protein family UPF0047
BC6307_24055	COG2002	toxin-antitoxin pair type II binding
BC6307_24065	COG1733	regulation of RNA biosynthetic process
BC6307_24070	COG2514	catechol 2,3-dioxygenase activity
BC6307_24080	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BC6307_24085	COG3973	AAA domain
BC6307_24100	COG1937	Protein conserved in bacteria
BC6307_24105	COG2608	mercury ion transmembrane transporter activity
BC6307_24110	COG2217	Heavy metal translocating P-type atpase
BC6307_24120	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BC6307_24135	COG1181	Belongs to the D-alanine--D-alanine ligase family
BC6307_24140	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BC6307_24145	COG0513	Belongs to the DEAD box helicase family
BC6307_24150	COG4294	response to UV
BC6307_24155	COG3402	PFAM membrane-flanked domain
BC6307_24160	COG3428	Bacterial PH domain
BC6307_24165	COG0705	Rhomboid family
BC6307_24170	COG0736	holo-[acyl-carrier-protein] synthase activity
BC6307_24175	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BC6307_24180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BC6307_24185	COG0864	Transcriptional regulator
BC6307_24190	COG2337	Toxic component of a toxin-antitoxin (TA) module
BC6307_24195	COG1366	Belongs to the anti-sigma-factor antagonist family
BC6307_24200	COG1366	Belongs to the anti-sigma-factor antagonist family
BC6307_24205	COG2172	sigma factor antagonist activity
BC6307_24210	COG2208	phosphoserine phosphatase activity
BC6307_24215	COG1366	Belongs to the anti-sigma-factor antagonist family
BC6307_24220	COG2172	sigma factor antagonist activity
BC6307_24225	COG1191	sigma factor activity
BC6307_24230	COG2208	phosphoserine phosphatase activity
BC6307_24235	COG2183	response to ionizing radiation
BC6307_24240	COG3091	SprT-like family
BC6307_24330	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BC6307_24335	COG0802	atpase or kinase
BC6307_24340	COG1214	PFAM Peptidase M22, glycoprotease
BC6307_24345	COG0456	acetyltransferase
BC6307_24350	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BC6307_24355	COG0488	(ABC) transporter
BC6307_24360	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BC6307_24365	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BC6307_24370	COG0805	protein transport
BC6307_24380	COG1266	CAAX protease self-immunity
BC6307_24385	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BC6307_24390	COG0459	protein refolding
BC6307_24405	COG0789	Transcriptional regulator
BC6307_24420	COG1842	Phage shock protein A
BC6307_24425	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BC6307_24430	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
BC6307_24435	COG4260	virion core protein, lumpy skin disease virus
BC6307_24440	COG1136	(ABC) transporter
BC6307_24445	COG0577	efflux transmembrane transporter activity
BC6307_24485	COG2304	oxidoreductase activity
BC6307_24535	COG0714	Associated with various cellular activities
BC6307_24540	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
BC6307_24545	COG1305	Transglutaminase-like
BC6307_24555	COG2252	PERMEase