locus-tag	class	description
CG474_000030	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CG474_000070	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CG474_000075	COG0592	DNA-directed DNA polymerase activity
CG474_000080	COG2501	S4 domain
CG474_000085	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CG474_000090	COG0187	DNA topoisomerase II activity
CG474_000095	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CG474_000130	COG0516	GMP reductase activity
CG474_000130	COG0517	IMP dehydrogenase activity
CG474_000135	COG1686	Belongs to the peptidase S11 family
CG474_000140	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CG474_000145	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CG474_000165	COG1428	Deoxynucleoside kinase
CG474_000170	COG1428	Deoxynucleoside kinase
CG474_000175	COG1335	isochorismatase
CG474_000180	COG0590	tRNA wobble adenosine to inosine editing
CG474_000190	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CG474_000195	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CG474_000200	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CG474_000245	COG1982	Orn Lys Arg decarboxylase major
CG474_000250	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CG474_000255	COG0470	DNA polymerase III
CG474_000260	COG1774	PSP1 C-terminal conserved region
CG474_000265	COG4467	Involved in initiation control of chromosome replication
CG474_000270	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CG474_000280	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CG474_000285	COG2002	toxin-antitoxin pair type II binding
CG474_000295	COG0084	hydrolase, TatD family'
CG474_000305	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CG474_000315	COG4466	Protein conserved in bacteria
CG474_000325	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CG474_000330	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CG474_000335	COG0251	oxidation-reduction process
CG474_000340	COG2088	sporulation resulting in formation of a cellular spore
CG474_000345	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CG474_000350	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CG474_000355	COG0193	aminoacyl-tRNA hydrolase activity
CG474_000365	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CG474_000370	COG2002	toxin-antitoxin pair type II binding
CG474_000375	COG2244	polysaccharide biosynthetic process
CG474_000380	COG3956	TIGRFAM MazG family protein
CG474_000385	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CG474_000405	COG1098	S1 RNA binding domain
CG474_000420	COG2208	phosphoserine phosphatase activity
CG474_000435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CG474_000440	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CG474_000445	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CG474_000450	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CG474_000455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CG474_000460	COG0512	Glutamine amidotransferase of anthranilate synthase
CG474_000465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CG474_000470	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CG474_000475	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CG474_000480	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CG474_000485	COG1396	sequence-specific DNA binding
CG474_000490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CG474_000495	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CG474_000530	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG474_000580	COG3880	PFAM UvrB UvrC protein
CG474_000585	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CG474_000590	COG0542	response to heat
CG474_000595	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CG474_000605	COG4956	integral membrane protein (PIN domain superfamily)
CG474_000610	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CG474_000615	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CG474_000620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CG474_000625	COG1045	serine acetyltransferase
CG474_000630	COG0215	cysteine-tRNA ligase activity
CG474_000640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CG474_000645	COG3688	RNA-binding protein containing a PIN domain
CG474_000665	COG0250	Participates in transcription elongation, termination and antitermination
CG474_000675	COG0081	regulation of translation
CG474_000680	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CG474_000685	COG0222	ribosome binding
CG474_000690	COG2813	Specifically methylates the guanine in position
CG474_000700	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CG474_000705	COG1358	cellular component organization or biogenesis
CG474_000710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CG474_000715	COG0049	tRNA binding
CG474_000720	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CG474_000725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CG474_000735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CG474_000740	COG0088	Forms part of the polypeptide exit tunnel
CG474_000745	COG0089	rRNA binding
CG474_000750	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CG474_000755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CG474_000760	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CG474_000765	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CG474_000770	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CG474_000780	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CG474_000785	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CG474_000790	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CG474_000795	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CG474_000805	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CG474_000810	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CG474_000815	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CG474_000820	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CG474_000825	COG1841	ribosomal large subunit assembly
CG474_000830	COG0200	Binds to the 23S rRNA
CG474_000835	COG0201	protein transport
CG474_000840	COG0563	adenylate kinase activity
CG474_000845	COG0024	Methionine aminopeptidase
CG474_000855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CG474_000865	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CG474_000870	COG0202	RNA polymerase activity
CG474_000885	COG1122	ATPase activity
CG474_000890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CG474_000900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CG474_000905	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CG474_000915	COG0860	N-Acetylmuramoyl-L-alanine amidase
CG474_000920	COG0489	protein tyrosine kinase activity
CG474_000930	COG2194	sulfuric ester hydrolase activity
CG474_000935	COG0726	polysaccharide deacetylase
CG474_001015	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CG474_001025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CG474_001090	COG0457	Tetratricopeptide repeat
CG474_001115	COG1266	CAAX protease self-immunity
CG474_001190	COG3681	Belongs to the UPF0597 family
CG474_001195	COG3681	Belongs to the UPF0597 family
CG474_001220	COG2814	Major facilitator Superfamily
CG474_001230	COG0601	transmembrane transport
CG474_001235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CG474_001240	COG0444	Belongs to the ABC transporter superfamily
CG474_001245	COG4608	Belongs to the ABC transporter superfamily
CG474_001250	COG4166	transmembrane transport
CG474_001270	COG1309	transcriptional regulator
CG474_001280	COG0656	L-ascorbic acid biosynthetic process
CG474_001285	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CG474_001295	COG4149	molybdate abc transporter
CG474_001300	COG0725	ABC transporter, periplasmic molybdate-binding protein
CG474_001305	COG1910	domain protein
CG474_001310	COG0204	Acyl-transferase
CG474_001315	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG474_001320	COG1648	precorrin-2 dehydrogenase activity
CG474_001320	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CG474_001330	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CG474_001330	COG1587	Uroporphyrinogen-III synthase
CG474_001335	COG2146	nitrite reductase [NAD(P)H] activity
CG474_001340	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CG474_001370	COG4585	Histidine kinase
CG474_001375	COG2197	response regulator
CG474_001380	COG1131	(ABC) transporter
CG474_001385	COG0842	Transport permease protein
CG474_001385	COG1511	domain protein
CG474_001390	COG0842	Transport permease protein
CG474_001400	COG0747	negative chemotaxis
CG474_001405	COG0601	transmembrane transport
CG474_001410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CG474_001415	COG0444	Belongs to the ABC transporter superfamily
CG474_001420	COG4608	Belongs to the ABC transporter superfamily
CG474_001425	COG0561	phosphatase activity
CG474_001445	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CG474_001450	COG0179	Fumarylacetoacetate (FAA) hydrolase
CG474_001460	COG2814	Major facilitator Superfamily
CG474_001465	COG1181	Belongs to the D-alanine--D-alanine ligase family
CG474_001470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CG474_001480	COG0457	Tetratricopeptide repeat
CG474_001480	COG0705	Rhomboid family
CG474_001485	COG0736	holo-[acyl-carrier-protein] synthase activity
CG474_001490	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CG474_001500	COG0864	Transcriptional regulator
CG474_001505	COG2337	Toxic component of a toxin-antitoxin (TA) module
CG474_001510	COG2183	response to ionizing radiation
CG474_001520	COG3091	SprT-like family
CG474_001560	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG474_001610	COG0802	atpase or kinase
CG474_001615	COG1214	PFAM Peptidase M22, glycoprotease
CG474_001620	COG0456	acetyltransferase
CG474_001630	COG0488	(ABC) transporter
CG474_001635	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CG474_001645	COG1266	CAAX protease self-immunity
CG474_001650	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CG474_001655	COG0459	protein refolding
CG474_001660	COG0519	Catalyzes the synthesis of GMP from XMP
CG474_001660	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CG474_001665	COG2252	PERMEase
CG474_001675	COG5002	protein histidine kinase activity
CG474_001745	COG2205	protein histidine kinase activity
CG474_001750	COG0745	RESPONSE REGULATOR receiver
CG474_001770	COG0697	spore germination
CG474_001795	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CG474_001800	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CG474_001805	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CG474_001810	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CG474_001815	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CG474_001820	COG0047	phosphoribosylformylglycinamidine synthase activity
CG474_001825	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CG474_001830	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CG474_001835	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CG474_001840	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CG474_001845	COG0138	bifunctional purine biosynthesis protein purh
CG474_001850	COG0151	Belongs to the GarS family
CG474_001860	COG0583	DNA-binding transcription factor activity
CG474_001880	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CG474_001885	COG0210	DNA helicase
CG474_001890	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CG474_001895	COG4851	CamS sex pheromone cAM373 precursor
CG474_001905	COG1012	belongs to the aldehyde dehydrogenase family
CG474_001910	COG1335	isochorismatase
CG474_001920	COG2011	ABC-type metal ion transport system permease component
CG474_001940	COG4682	membrane
CG474_001945	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CG474_001950	COG0154	amidase activity
CG474_001955	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CG474_001960	COG1597	lipid kinase activity
CG474_001965	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CG474_001970	COG0546	phosphoglycolate phosphatase activity
CG474_001975	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CG474_001985	COG0531	amino acid
CG474_001990	COG1012	belongs to the aldehyde dehydrogenase family
CG474_001995	COG2076	Multidrug Resistance protein
CG474_002000	COG2309	aminopeptidase activity
CG474_002010	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG474_002015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CG474_002020	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CG474_002035	COG0450	alkyl hydroperoxide reductase
CG474_002060	COG0714	Associated with various cellular activities
CG474_002095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG474_002100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG474_002105	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG474_002110	COG0492	ferredoxin-NADP+ reductase activity
CG474_002120	COG0166	Belongs to the GPI family
CG474_002125	COG5002	protein histidine kinase activity
CG474_002155	COG2814	Major facilitator Superfamily
CG474_002160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CG474_002160	COG0723	plastoquinol--plastocyanin reductase activity
CG474_002170	COG0765	amino acid transport
CG474_002175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG474_002180	COG1126	abc transporter atp-binding protein
CG474_002185	COG0840	transmembrane signaling receptor activity
CG474_002195	COG2235	arginine
CG474_002210	COG0549	Belongs to the carbamate kinase family
CG474_002225	COG0366	Alpha amylase catalytic
CG474_002230	COG1263	PTS System
CG474_002230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG474_002230	COG2190	(PTS) system
CG474_002250	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG474_002255	COG4605	iron ion homeostasis
CG474_002260	COG4604	ABC transporter, ATP-binding protein
CG474_002265	COG4607	ABC-type enterochelin transport system periplasmic component
CG474_002270	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CG474_002275	COG0352	thiamine-phosphate diphosphorylase activity
CG474_002280	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CG474_002300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG474_002310	COG1116	anion transmembrane transporter activity
CG474_002345	COG2270	Major facilitator Superfamily
CG474_002370	COG2310	stress, protein
CG474_002375	COG2310	stress, protein
CG474_002380	COG2310	stress, protein
CG474_002385	COG0861	Integral membrane protein TerC family
CG474_002395	COG3853	Toxic anion resistance protein (TelA)
CG474_002405	COG4840	Belongs to the UPF0435 family
CG474_002410	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CG474_002420	COG1295	ribonuclease BN
CG474_002425	COG2217	Heavy metal translocating P-type atpase
CG474_002430	COG0697	spore germination
CG474_002440	COG0681	Belongs to the peptidase S26 family
CG474_002450	COG0586	Pfam SNARE associated Golgi protein
CG474_002465	COG0387	Pfam Sodium calcium exchanger
CG474_002475	COG0535	radical SAM domain protein
CG474_002495	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CG474_002530	COG2066	Belongs to the glutaminase family
CG474_002535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG474_002535	COG1263	PTS System
CG474_002540	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG474_002550	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CG474_002550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CG474_002560	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CG474_002565	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CG474_002580	COG0402	S-adenosylhomocysteine deaminase activity
CG474_002585	COG2137	regulation of response to DNA damage stimulus
CG474_002610	COG1988	membrane-bound metal-dependent
CG474_002615	COG1194	a g-specific adenine glycosylase
CG474_002640	COG3557	Belongs to the UPF0374 family
CG474_002645	COG1132	(ABC) transporter
CG474_002650	COG4129	membrane
CG474_002655	COG0067	glutamate synthase
CG474_002655	COG0069	glutamate synthase activity
CG474_002655	COG0070	glutamate synthase
CG474_002660	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CG474_002665	COG4555	ABC transporter
CG474_002685	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CG474_002690	COG0735	belongs to the Fur family
CG474_002810	COG0457	Tetratricopeptide repeat
CG474_002815	COG0217	transcriptional regulatory protein
CG474_002820	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CG474_002825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CG474_002845	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CG474_002855	COG2766	serine protein kinase
CG474_002880	COG1280	lysine exporter protein (LysE YggA)
CG474_002920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CG474_002930	COG1585	Membrane protein implicated in regulation of membrane protease activity
CG474_002935	COG2268	Band 7 protein
CG474_002975	COG3290	protein histidine kinase activity
CG474_002980	COG4565	transcriptional regulatory protein
CG474_002985	COG3493	citrate carrier protein
CG474_002990	COG0281	malic enzyme
CG474_003005	COG5002	protein histidine kinase activity
CG474_003010	COG0745	RESPONSE REGULATOR receiver
CG474_003020	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CG474_003025	COG3383	formate dehydrogenase (NAD+) activity
CG474_003030	COG2427	Protein of unknown function (DUF1641)
CG474_003040	COG0840	transmembrane signaling receptor activity
CG474_003050	COG0531	amino acid
CG474_003065	COG0640	Transcriptional regulator
CG474_003070	COG2217	Heavy metal translocating P-type atpase
CG474_003075	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CG474_003085	COG3227	Zinc metalloprotease (Elastase)
CG474_003100	COG2217	Heavy metal translocating P-type atpase
CG474_003120	COG2720	vancomycin resistance protein
CG474_003125	COG1316	TRANSCRIPTIONal
CG474_003135	COG1253	flavin adenine dinucleotide binding
CG474_003140	COG1027	Aspartate ammonia-lyase
CG474_003145	COG1620	l-lactate permease
CG474_003165	COG3104	oligopeptide transport
CG474_003170	COG0156	8-amino-7-oxononanoate synthase activity
CG474_003175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CG474_003180	COG4548	von Willebrand factor, type A
CG474_003185	COG0714	Associated with various cellular activities
CG474_003190	COG0531	amino acid
CG474_003195	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG474_003200	COG1115	amino acid carrier protein
CG474_003210	COG1126	abc transporter atp-binding protein
CG474_003215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG474_003220	COG0765	amino acid transport
CG474_003225	COG0765	amino acid transport
CG474_003230	COG0833	amino acid
CG474_003240	COG5002	protein histidine kinase activity
CG474_003245	COG0745	RESPONSE REGULATOR receiver
CG474_003255	COG0659	secondary active sulfate transmembrane transporter activity
CG474_003260	COG0589	response to stress
CG474_003270	COG0747	negative chemotaxis
CG474_003280	COG0601	transmembrane transport
CG474_003285	COG4608	Belongs to the ABC transporter superfamily
CG474_003295	COG2271	Major facilitator Superfamily
CG474_003300	COG1846	Transcriptional regulator
CG474_003305	COG0477	Major facilitator Superfamily
CG474_003310	COG1609	Transcriptional regulator
CG474_003315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CG474_003320	COG1869	D-ribose catabolic process
CG474_003325	COG1129	ABC transporter
CG474_003330	COG1172	Belongs to the binding-protein-dependent transport system permease family
CG474_003335	COG1879	ABC-type sugar transport system periplasmic component
CG474_003340	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CG474_003355	COG3568	Endonuclease Exonuclease Phosphatase
CG474_003380	COG0840	transmembrane signaling receptor activity
CG474_003385	COG3583	domain protein
CG474_003385	COG3584	3D domain protein
CG474_003390	COG1476	TRANSCRIPTIONal
CG474_003420	COG1114	Component of the transport system for branched-chain amino acids
CG474_003430	COG1113	amino acid transport
CG474_003435	COG2153	protein acetylation
CG474_003445	COG0475	glutathione-regulated potassium exporter activity
CG474_003445	COG0569	domain protein
CG474_003460	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CG474_003465	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CG474_003470	COG0833	amino acid
CG474_003475	COG4990	cell redox homeostasis
CG474_003490	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG474_003495	COG0697	spore germination
CG474_003500	COG0531	amino acid
CG474_003515	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CG474_003520	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CG474_003525	COG1918	ferrous iron import across plasma membrane
CG474_003525	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CG474_003530	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CG474_003535	COG0573	inorganic phosphate transmembrane transporter activity
CG474_003540	COG0581	inorganic phosphate transmembrane transporter activity
CG474_003545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CG474_003585	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG474_003660	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CG474_003685	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CG474_003690	COG1116	anion transmembrane transporter activity
CG474_003695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG474_003700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CG474_003705	COG0352	thiamine-phosphate diphosphorylase activity
CG474_003710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CG474_003715	COG2104	thiamine diphosphate biosynthetic process
CG474_003720	COG2022	thiamine diphosphate biosynthetic process
CG474_003725	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG474_003730	COG0351	phosphomethylpyrimidine kinase
CG474_003765	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CG474_003770	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CG474_003775	COG2205	protein histidine kinase activity
CG474_003780	COG2814	Major facilitator Superfamily
CG474_003785	COG1846	Transcriptional regulator
CG474_003795	COG2252	PERMEase
CG474_003800	COG1028	Short-chain dehydrogenase reductase Sdr
CG474_003805	COG1376	ErfK ybiS ycfS ynhG family protein
CG474_003860	COG0778	Nitroreductase
CG474_003870	COG2719	SpoVR family
CG474_003880	COG1316	TRANSCRIPTIONal
CG474_003885	COG1283	sodium-dependent phosphate transmembrane transporter activity
CG474_003900	COG0577	efflux transmembrane transporter activity
CG474_003905	COG1136	(ABC) transporter
CG474_003915	COG1114	Component of the transport system for branched-chain amino acids
CG474_003920	COG3546	catalase activity
CG474_003975	COG0475	glutathione-regulated potassium exporter activity
CG474_003980	COG1737	Transcriptional regulator
CG474_003990	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CG474_003995	COG1263	PTS System
CG474_003995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG474_004010	COG1522	sequence-specific DNA binding
CG474_004025	COG0531	amino acid
CG474_004035	COG1012	belongs to the aldehyde dehydrogenase family
CG474_004040	COG1132	(ABC) transporter
CG474_004045	COG1132	(ABC) transporter
CG474_004055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG474_004060	COG0765	amino acid transport
CG474_004065	COG1126	abc transporter atp-binding protein
CG474_004080	COG0189	ligase activity
CG474_004085	COG4399	Belongs to the UPF0754 family
CG474_004090	COG3679	Belongs to the UPF0342 family
CG474_004095	COG4585	Histidine kinase
CG474_004100	COG2197	response regulator
CG474_004150	COG2094	Belongs to the DNA glycosylase MPG family
CG474_004155	COG0561	phosphatase activity
CG474_004165	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CG474_004195	COG2244	polysaccharide biosynthetic process
CG474_004205	COG0860	N-Acetylmuramoyl-L-alanine amidase
CG474_004225	COG1696	Membrane protein involved in D-alanine export
CG474_004240	COG1024	Enoyl-CoA hydratase
CG474_004255	COG1363	Peptidase, m42
CG474_004270	COG2239	Acts as a magnesium transporter
CG474_004280	COG1115	amino acid carrier protein
CG474_004355	COG1476	TRANSCRIPTIONal
CG474_004490	COG3829	transcription factor binding
CG474_004490	COG3290	protein histidine kinase activity
CG474_004515	COG1061	Type III restriction enzyme res subunit
CG474_004555	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CG474_004565	COG4638	Rieske (2fe-2S)
CG474_004570	COG1012	belongs to the aldehyde dehydrogenase family
CG474_004575	COG0473	3-isopropylmalate dehydrogenase activity
CG474_004585	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG474_004595	COG1064	alcohol dehydrogenase
CG474_004610	COG3246	L-lysine catabolic process to acetate
CG474_004645	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CG474_004655	COG4641	Protein conserved in bacteria
CG474_004670	COG3711	transcriptional antiterminator
CG474_004675	COG1263	PTS System
CG474_004675	COG2190	(PTS) system
CG474_004675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG474_004680	COG2723	6-phospho-beta-galactosidase activity
CG474_004690	COG2376	Dihydroxyacetone kinase
CG474_004695	COG0393	Putative heavy-metal-binding
CG474_004725	COG0420	3'-5' exonuclease activity
CG474_004730	COG4717	serine-type aminopeptidase activity
CG474_004735	COG3481	metal-dependent phosphohydrolase, HD sub domain
CG474_004750	COG0577	efflux transmembrane transporter activity
CG474_004755	COG1136	(ABC) transporter
CG474_004765	COG5002	protein histidine kinase activity
CG474_004770	COG0745	RESPONSE REGULATOR receiver
CG474_004780	COG1316	TRANSCRIPTIONal
CG474_004795	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CG474_004800	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CG474_004805	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CG474_004810	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CG474_004830	COG1846	Transcriptional regulator
CG474_004835	COG4980	gas vesicle protein
CG474_004845	COG0537	adenosine 5'-monophosphoramidase activity
CG474_004850	COG1131	(ABC) transporter
CG474_004855	COG4473	ABC transporter
CG474_004875	COG3402	PFAM membrane-flanked domain
CG474_004885	COG2329	Antibiotic biosynthesis monooxygenase
CG474_004890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG474_004895	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CG474_004935	COG1309	transcriptional regulator
CG474_004945	COG1216	Glycosyl transferase, family 2
CG474_004945	COG0438	transferase activity, transferring glycosyl groups
CG474_004960	COG1609	Transcriptional regulator
CG474_004970	COG1234	tRNA 3'-trailer cleavage
CG474_004975	COG0095	Lipoate-protein ligase
CG474_004985	COG0318	PFAM AMP-dependent synthetase and ligase
CG474_005000	COG2205	protein histidine kinase activity
CG474_005005	COG0745	RESPONSE REGULATOR receiver
CG474_005025	COG0501	Belongs to the peptidase M48B family
CG474_005030	COG0840	transmembrane signaling receptor activity
CG474_005035	COG0697	spore germination
CG474_005050	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CG474_005055	COG2224	Isocitrate lyase
CG474_005060	COG1278	Cold shock
CG474_005070	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CG474_005080	COG1396	sequence-specific DNA binding
CG474_005170	COG1598	PFAM Uncharacterised protein family UPF0150
CG474_005290	COG5632	N-Acetylmuramoyl-L-alanine amidase
CG474_005305	COG3708	Transcriptional regulator
CG474_005305	COG2207	Transcriptional regulator
CG474_005340	COG0398	Pfam SNARE associated Golgi protein
CG474_005350	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CG474_005355	COG1074	ATP-dependent DNA helicase activity
CG474_005395	COG0179	Fumarylacetoacetate (FAA) hydrolase
CG474_005415	COG0367	asparagine synthase
CG474_005425	COG0753	catalase activity
CG474_005435	COG1874	Beta-galactosidase
CG474_005435	COG0366	Alpha amylase catalytic
CG474_005440	COG1666	GTP binding
CG474_005445	COG2996	Protein conserved in bacteria
CG474_005460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG474_005475	COG0561	phosphatase activity
CG474_005500	COG2267	carboxylic ester hydrolase activity
CG474_005515	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CG474_005520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CG474_005525	COG5504	Zn-dependent protease
CG474_005535	COG0180	Tryptophanyl-tRNA synthetase
CG474_005550	COG4166	transmembrane transport
CG474_005555	COG0601	transmembrane transport
CG474_005560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CG474_005565	COG0444	Belongs to the ABC transporter superfamily
CG474_005570	COG4608	Belongs to the ABC transporter superfamily
CG474_005575	COG0534	Mate efflux family protein
CG474_005580	COG4166	transmembrane transport
CG474_005600	COG1393	Belongs to the ArsC family
CG474_005605	COG0861	Integral membrane protein TerC family
CG474_005625	COG1164	Oligoendopeptidase f
CG474_005640	COG2346	COG2346, Truncated hemoglobins
CG474_005645	COG4116	CYTH
CG474_005655	COG2357	RelA SpoT domain protein
CG474_005665	COG0564	pseudouridine synthase activity
CG474_005675	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CG474_005680	COG0772	Belongs to the SEDS family
CG474_005725	COG1216	Glycosyl transferase, family 2
CG474_005745	COG0457	Tetratricopeptide repeat
CG474_005745	COG0463	Glycosyl transferase, family 2
CG474_005765	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CG474_005780	COG1091	dTDP-4-dehydrorhamnose reductase activity
CG474_005805	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CG474_005810	COG2382	esterase
CG474_005825	COG5492	domain, Protein
CG474_005830	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG474_005845	COG1620	l-lactate permease
CG474_005850	COG5634	Uncharacterized conserved protein (DUF2278)
CG474_005890	COG0508	dehydrogenase complex catalyzes the overall conversion of
CG474_005895	COG0567	Dehydrogenase, E1 component
CG474_005905	COG0583	DNA-binding transcription factor activity
CG474_005910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CG474_005915	COG1012	belongs to the aldehyde dehydrogenase family
CG474_005930	COG0196	riboflavin kinase activity
CG474_005935	COG3162	membrane
CG474_005940	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG474_005945	COG0179	Fumarylacetoacetate (FAA) hydrolase
CG474_005960	COG0457	Tetratricopeptide repeat
CG474_006015	COG0673	inositol 2-dehydrogenase activity
CG474_006045	COG0457	Tetratricopeptide repeat
CG474_006050	COG0582	viral genome integration into host DNA
CG474_006085	COG1686	Belongs to the peptidase S11 family
CG474_006090	COG0681	Belongs to the peptidase S26 family
CG474_006125	COG1012	belongs to the aldehyde dehydrogenase family
CG474_006135	COG1176	ABC-type spermidine putrescine transport system, permease component I
CG474_006140	COG1177	transmembrane transport
CG474_006145	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CG474_006150	COG0671	phosphoesterase, PA-phosphatase related
CG474_006155	COG2409	Drug exporters of the RND superfamily
CG474_006165	COG0564	pseudouridine synthase activity
CG474_006175	COG2340	Cysteine-rich secretory protein family
CG474_006180	COG0247	lactate metabolic process
CG474_006185	COG0277	FAD linked oxidase domain protein
CG474_006190	COG3835	regulator
CG474_006200	COG0745	RESPONSE REGULATOR receiver
CG474_006205	COG5002	protein histidine kinase activity
CG474_006210	COG2186	Transcriptional regulator
CG474_006215	COG0247	lactate metabolic process
CG474_006220	COG1139	Iron-sulfur cluster binding protein
CG474_006225	COG1556	Lactate utilization protein
CG474_006230	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CG474_006235	COG0584	glycerophosphoryl diester phosphodiesterase
CG474_006245	COG2267	carboxylic ester hydrolase activity
CG474_006250	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG474_006260	COG2116	formate transmembrane transporter activity
CG474_006265	COG0861	Integral membrane protein TerC family
CG474_006270	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CG474_006280	COG2030	dehydratase
CG474_006300	COG1028	Short-chain dehydrogenase reductase Sdr
CG474_006305	COG3243	poly(R)-hydroxyalkanoic acid synthase
CG474_006310	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CG474_006325	COG1840	ABC-type Fe3 transport system, periplasmic component
CG474_006330	COG3842	ATPase activity
CG474_006340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CG474_006345	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CG474_006350	COG1349	DNA-binding transcription factor activity
CG474_006355	COG0235	Class ii aldolase
CG474_006365	COG2861	carbohydrate metabolic process
CG474_006375	COG3852	Histidine kinase
CG474_006380	COG1846	Transcriptional regulator
CG474_006400	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CG474_006405	COG0720	synthase
CG474_006415	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CG474_006420	COG4873	Protein conserved in bacteria
CG474_006430	COG0456	acetyltransferase
CG474_006450	COG1780	Probably involved in ribonucleotide reductase function
CG474_006465	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CG474_006470	COG1725	Transcriptional regulator
CG474_006475	COG1131	(ABC) transporter
CG474_006485	COG1131	(ABC) transporter
CG474_006490	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CG474_006505	COG1522	sequence-specific DNA binding
CG474_006520	COG1619	proteins homologs of microcin C7 resistance protein MccF
CG474_006525	COG2070	2-Nitropropane dioxygenase
CG474_006530	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CG474_006540	COG1696	Membrane protein involved in D-alanine export
CG474_006545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CG474_006560	COG0716	FMN binding
CG474_006585	COG1368	sulfuric ester hydrolase activity
CG474_006595	COG3173	Aminoglycoside phosphotransferase
CG474_006610	COG5609	conserved protein (DUF2294)
CG474_006615	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CG474_006620	COG3002	Belongs to the UPF0753 family
CG474_006625	COG0288	reversible hydration of carbon dioxide
CG474_006630	COG0534	Mate efflux family protein
CG474_006645	COG1846	Transcriptional regulator
CG474_006655	COG1301	dicarboxylic acid transport
CG474_006660	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CG474_006670	COG3874	Sporulation protein YtfJ
CG474_006690	COG0028	Belongs to the TPP enzyme family
CG474_006695	COG0440	acetolactate synthase activity
CG474_006700	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CG474_006705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CG474_006715	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CG474_006720	COG0066	3-isopropylmalate dehydratase activity
CG474_006730	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CG474_006740	COG0131	Imidazoleglycerol-phosphate dehydratase
CG474_006745	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CG474_006750	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CG474_006755	COG0107	imidazoleglycerol-phosphate synthase activity
CG474_006760	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CG474_006765	COG0140	phosphoribosyl-ATP diphosphatase activity
CG474_006780	COG1183	phosphatidylcholine synthase activity
CG474_006785	COG1368	sulfuric ester hydrolase activity
CG474_006805	COG0175	sulfate reduction
CG474_006810	COG2046	Belongs to the sulfate adenylyltransferase family
CG474_006815	COG0529	Catalyzes the synthesis of activated sulfate
CG474_006820	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CG474_006840	COG1648	precorrin-2 dehydrogenase activity
CG474_006840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CG474_006845	COG0733	neurotransmitter:sodium symporter activity
CG474_006860	COG3557	Belongs to the UPF0374 family
CG474_006865	COG1757	Na H antiporter
CG474_006880	COG4758	membrane
CG474_006885	COG4585	Histidine kinase
CG474_006890	COG2197	response regulator
CG474_006895	COG1114	Component of the transport system for branched-chain amino acids
CG474_006900	COG1525	nuclease
CG474_006900	COG0737	Belongs to the 5'-nucleotidase family
CG474_006900	COG4085	toxin activity
CG474_006930	COG3711	transcriptional antiterminator
CG474_006930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG474_006935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG474_006935	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG474_006935	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG474_006940	COG1482	cell wall glycoprotein biosynthetic process
CG474_006950	COG2801	Transposase and inactivated derivatives
CG474_006970	COG0730	response to heat
CG474_006975	COG0306	phosphate transporter
CG474_006980	COG1392	Phosphate transport regulator
CG474_006985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG474_006995	COG3852	Histidine kinase
CG474_007000	COG1801	Protein of unknown function DUF72
CG474_007010	COG0582	viral genome integration into host DNA
CG474_007015	COG5002	protein histidine kinase activity
CG474_007020	COG0813	purine-nucleoside phosphorylase activity
CG474_007030	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CG474_007030	COG0392	lysyltransferase activity
CG474_007045	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CG474_007050	COG1686	Belongs to the peptidase S11 family
CG474_007055	COG2715	membrane protein required for spore maturation
CG474_007060	COG0700	Nucleoside recognition
CG474_007065	COG1187	pseudouridine synthase activity
CG474_007075	COG1333	cytochrome c biogenesis protein
CG474_007080	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CG474_007085	COG0745	RESPONSE REGULATOR receiver
CG474_007090	COG5002	protein histidine kinase activity
CG474_007095	COG2096	Adenosyltransferase
CG474_007110	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CG474_007115	COG1141	Ferredoxin
CG474_007125	COG0514	ATP-dependent DNA helicase (RecQ)
CG474_007130	COG1266	CAAX protease self-immunity
CG474_007140	COG1408	metallophosphoesterase
CG474_007155	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CG474_007170	COG0492	ferredoxin-NADP+ reductase activity
CG474_007185	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CG474_007195	COG1304	FMN binding
CG474_007220	COG1160	GTP binding
CG474_007225	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CG474_007245	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CG474_007255	COG0302	gtp cyclohydrolase
CG474_007260	COG0142	geranyltranstransferase activity
CG474_007265	COG2226	methyltransferase
CG474_007270	COG0142	geranyltranstransferase activity
CG474_007275	COG0105	UTP biosynthetic process
CG474_007280	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CG474_007285	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CG474_007290	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CG474_007295	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CG474_007300	COG0457	Tetratricopeptide repeat
CG474_007305	COG5582	Belongs to the UPF0302 family
CG474_007320	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CG474_007330	COG4347	Protein of unknown function (DUF1405)
CG474_007345	COG2738	Putative neutral zinc metallopeptidase
CG474_007355	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG474_007360	COG1694	Mazg nucleotide pyrophosphohydrolase
CG474_007365	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CG474_007370	COG1803	Methylglyoxal synthase
CG474_007375	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CG474_007380	COG0438	transferase activity, transferring glycosyl groups
CG474_007385	COG0617	tRNA 3'-terminal CCA addition
CG474_007400	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CG474_007405	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CG474_007410	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CG474_007415	COG1199	ATP-dependent helicase activity
CG474_007415	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CG474_007435	COG3935	DnaD domain protein
CG474_007440	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CG474_007450	COG4499	WXG100 protein secretion system (Wss), protein YukC
CG474_007450	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG474_007455	COG3331	DNA recombination
CG474_007490	COG4474	Belongs to the UPF0398 family
CG474_007495	COG3599	regulation of cell shape
CG474_007505	COG0116	Belongs to the methyltransferase superfamily
CG474_007515	COG1199	ATP-dependent helicase activity
CG474_007520	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CG474_007530	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CG474_007535	COG2233	PERMEase
CG474_007540	COG2311	Membrane
CG474_007545	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CG474_007555	COG0456	acetyltransferase
CG474_007595	COG3766	membrane
CG474_007600	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CG474_007605	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CG474_007610	COG1733	regulation of RNA biosynthetic process
CG474_007630	COG0328	RNA-DNA hybrid ribonuclease activity
CG474_007660	COG1278	Cold shock
CG474_007670	COG3162	membrane
CG474_007675	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG474_007680	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CG474_007685	COG0475	glutathione-regulated potassium exporter activity
CG474_007690	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CG474_007695	COG2323	membrane
CG474_007700	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CG474_007725	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CG474_007735	COG2201	protein-glutamate methylesterase activity
CG474_007740	COG0643	Histidine kinase
CG474_007740	COG2198	Histidine kinase
CG474_007745	COG1776	CheC inhibitor of MCP methylation
CG474_007745	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG474_007760	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CG474_007770	COG1728	Protein conserved in bacteria
CG474_007780	COG1256	bacterial-type flagellum assembly
CG474_007785	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CG474_007805	COG1815	bacterial-type flagellum-dependent cell motility
CG474_007810	COG1558	bacterial-type flagellum-dependent cell motility
CG474_007815	COG1677	Flagellar hook-basal body complex protein FliE
CG474_007825	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG474_007835	COG1157	protein secretion by the type III secretion system
CG474_007870	COG0835	chemotaxis
CG474_007870	COG0784	Response regulator, receiver
CG474_007880	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CG474_007885	COG0457	Tetratricopeptide repeat
CG474_007885	COG0463	Glycosyl transferase, family 2
CG474_007900	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CG474_007905	COG0741	lytic transglycosylase activity
CG474_007915	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG474_007920	COG1776	CheC inhibitor of MCP methylation
CG474_007920	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG474_007930	COG1338	Plays a role in the flagellum-specific transport system
CG474_007935	COG1987	bacterial-type flagellum assembly
CG474_007945	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CG474_007950	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CG474_007955	COG1419	protein localization to endoplasmic reticulum
CG474_007960	COG4786	Flagellar basal body rod
CG474_007965	COG1136	(ABC) transporter
CG474_007965	COG0577	efflux transmembrane transporter activity
CG474_007995	COG1309	transcriptional regulator
CG474_008015	COG2814	Major facilitator Superfamily
CG474_008025	COG1028	Short-chain dehydrogenase reductase Sdr
CG474_008060	COG0367	asparagine synthase
CG474_008080	COG1802	Transcriptional regulator
CG474_008085	COG0697	spore germination
CG474_008095	COG1757	Na H antiporter
CG474_008100	COG0114	fumarate hydratase activity
CG474_008125	COG0534	Mate efflux family protein
CG474_008130	COG3340	Belongs to the peptidase S51 family
CG474_008135	COG2733	membrane
CG474_008145	COG1280	lysine exporter protein (LysE YggA)
CG474_008150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CG474_008165	COG2502	aspartate--ammonia ligase
CG474_008170	COG1309	transcriptional regulator
CG474_008175	COG0109	protoheme IX farnesyltransferase activity
CG474_008205	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CG474_008215	COG4166	transmembrane transport
CG474_008220	COG2223	nitrite transmembrane transporter activity
CG474_008225	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CG474_008230	COG2244	polysaccharide biosynthetic process
CG474_008235	COG0733	neurotransmitter:sodium symporter activity
CG474_008240	COG5566	PFAM Mor transcription activator
CG474_008250	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CG474_008255	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CG474_008265	COG0129	dihydroxy-acid dehydratase activity
CG474_008270	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CG474_008275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG474_008280	COG2814	Major facilitator Superfamily
CG474_008285	COG3384	dioxygenase
CG474_008305	COG0402	S-adenosylhomocysteine deaminase activity
CG474_008310	COG4166	transmembrane transport
CG474_008320	COG1914	H( )-stimulated, divalent metal cation uptake system
CG474_008335	COG0083	homoserine kinase activity
CG474_008345	COG2390	Transcriptional regulator
CG474_008350	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CG474_008375	COG1510	regulation of RNA biosynthetic process
CG474_008385	COG1454	alcohol dehydrogenase
CG474_008400	COG1012	belongs to the aldehyde dehydrogenase family
CG474_008415	COG0628	permease
CG474_008420	COG0039	L-malate dehydrogenase activity
CG474_008425	COG0523	cobalamin synthesis protein
CG474_008450	COG1686	Belongs to the peptidase S11 family
CG474_008465	COG0791	NLP P60 protein
CG474_008465	COG1388	LysM domain
CG474_008470	COG0300	oxidoreductase activity
CG474_008480	COG0460	homoserine dehydrogenase
CG474_008490	COG0083	homoserine kinase activity
CG474_008495	COG1316	TRANSCRIPTIONal
CG474_008500	COG0726	polysaccharide deacetylase
CG474_008510	COG1285	pathogenesis
CG474_008515	COG1247	-acetyltransferase
CG474_008550	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CG474_008555	COG0577	efflux transmembrane transporter activity
CG474_008560	COG2409	Drug exporters of the RND superfamily
CG474_008565	COG1404	Belongs to the peptidase S8 family
CG474_008580	COG0840	transmembrane signaling receptor activity
CG474_008600	COG0783	Belongs to the Dps family
CG474_008620	COG0523	cobalamin synthesis protein
CG474_008630	COG0803	Belongs to the bacterial solute-binding protein 9 family
CG474_008645	COG1902	pentaerythritol trinitrate reductase activity
CG474_008650	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CG474_008660	COG4166	transmembrane transport
CG474_008665	COG0346	lactoylglutathione lyase activity
CG474_008675	COG5337	Spore coat protein CotH
CG474_008680	COG1051	belongs to the nudix hydrolase family
CG474_008685	COG0586	Pfam SNARE associated Golgi protein
CG474_008690	COG2244	polysaccharide biosynthetic process
CG474_008700	COG0701	Predicted permease
CG474_008705	COG3689	TIGRFAM TIGR03943 family protein
CG474_008710	COG1607	acyl-coa hydrolase
CG474_008720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CG474_008730	COG1028	Short-chain dehydrogenase reductase Sdr
CG474_008740	COG2839	Protein conserved in bacteria
CG474_008745	COG1253	flavin adenine dinucleotide binding
CG474_008760	COG1114	Component of the transport system for branched-chain amino acids
CG474_008785	COG0860	N-Acetylmuramoyl-L-alanine amidase
CG474_008795	COG1876	peptidase activity
CG474_008845	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CG474_008850	COG1819	glycosyl
CG474_008855	COG1819	glycosyl
CG474_008860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG474_008905	COG4499	WXG100 protein secretion system (Wss), protein YukC
CG474_008945	COG3874	Sporulation protein YtfJ
CG474_008970	COG2226	methyltransferase
CG474_008995	COG0386	Belongs to the glutathione peroxidase family
CG474_009025	COG0640	Transcriptional regulator
CG474_009030	COG0798	PFAM Bile acid sodium symporter
CG474_009035	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CG474_009080	COG1418	mRNA catabolic process
CG474_009085	COG0488	(ABC) transporter
CG474_009095	COG0629	single-stranded DNA binding
CG474_009100	COG1413	lyase activity
CG474_009115	COG2521	methyltransferase
CG474_009115	COG2136	Putative SAM-dependent methyltransferase
CG474_009120	COG0018	arginyl-trna synthetase
CG474_009130	COG0733	neurotransmitter:sodium symporter activity
CG474_009150	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG474_009155	COG0477	Major facilitator Superfamily
CG474_009170	COG1454	alcohol dehydrogenase
CG474_009175	COG2610	gluconate transmembrane transporter activity
CG474_009185	COG0456	acetyltransferase
CG474_009190	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CG474_009200	COG1131	(ABC) transporter
CG474_009205	COG4473	ABC transporter
CG474_009220	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG474_009225	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CG474_009235	COG0768	penicillin binding
CG474_009245	COG0204	Acyl-transferase
CG474_009250	COG1272	protein, Hemolysin III
CG474_009255	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CG474_009260	COG0805	protein transport
CG474_009270	COG1307	EDD domain protein, DegV family
CG474_009280	COG1999	signal sequence binding
CG474_009285	COG0071	Belongs to the small heat shock protein (HSP20) family
CG474_009290	COG0367	asparagine synthase
CG474_009305	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CG474_009325	COG0071	Belongs to the small heat shock protein (HSP20) family
CG474_009335	COG1737	Transcriptional regulator
CG474_009340	COG1070	Carbohydrate kinase
CG474_009350	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CG474_009405	COG1151	hydroxylamine reductase activity
CG474_009415	COG1253	flavin adenine dinucleotide binding
CG474_009420	COG5506	Protein of unknown function (DUF1694)
CG474_009440	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CG474_009445	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CG474_009450	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CG474_009455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CG474_009465	COG3829	transcription factor binding
CG474_009475	COG1509	lysine 2,3-aminomutase activity
CG474_009485	COG4479	Belongs to the UPF0346 family
CG474_009490	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CG474_009520	COG0515	serine threonine protein kinase
CG474_009520	COG1357	PFAM Pentapeptide repeats (8 copies)
CG474_009525	COG0671	phosphoesterase, PA-phosphatase related
CG474_009530	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CG474_009535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG474_009580	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CG474_009590	COG0726	polysaccharide deacetylase
CG474_009595	COG1408	metallophosphoesterase
CG474_009600	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CG474_009605	COG2323	membrane
CG474_009610	COG0671	phosphoesterase, PA-phosphatase related
CG474_009620	COG1280	lysine exporter protein (LysE YggA)
CG474_009625	COG3403	YqcI/YcgG family
CG474_009655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG474_009655	COG4499	WXG100 protein secretion system (Wss), protein YukC
CG474_009665	COG0372	Belongs to the citrate synthase family
CG474_009670	COG2079	MmgE PrpD family protein
CG474_009675	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CG474_009680	COG1960	acyl-CoA dehydrogenase activity
CG474_009685	COG2084	Dehydrogenase
CG474_009690	COG1012	belongs to the aldehyde dehydrogenase family
CG474_009700	COG1280	lysine exporter protein (LysE YggA)
CG474_009720	COG0420	3'-5' exonuclease activity
CG474_009725	COG0419	ATPase involved in DNA repair
CG474_009730	COG3104	oligopeptide transport
CG474_009755	COG1131	(ABC) transporter
CG474_009775	COG1131	(ABC) transporter
CG474_009780	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CG474_009800	COG1942	4-Oxalocrotonate Tautomerase
CG474_009815	COG1028	Short-chain dehydrogenase reductase Sdr
CG474_009820	COG1169	isochorismate synthase
CG474_009825	COG1021	2,3-dihydroxybenzoate-AMP ligase
CG474_009830	COG1535	isochorismatase
CG474_009830	COG3433	isochorismatase activity
CG474_009835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CG474_009840	COG3251	PFAM MbtH domain protein
CG474_009845	COG2814	Major facilitator Superfamily
CG474_009910	COG0776	regulation of translation
CG474_009925	COG2329	Antibiotic biosynthesis monooxygenase
CG474_009965	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CG474_009975	COG0667	Aldo Keto reductase
CG474_009995	COG0010	Belongs to the arginase family
CG474_010005	COG1132	(ABC) transporter
CG474_010010	COG1132	(ABC) transporter
CG474_010040	COG1649	PFAM Uncharacterised BCR, COG1649
CG474_010055	COG2971	BadF BadG BcrA BcrD
CG474_010075	COG0588	phosphoglycerate mutase activity
CG474_010105	COG2195	Cleaves the N-terminal amino acid of tripeptides
CG474_010115	COG1960	acyl-CoA dehydrogenase activity
CG474_010120	COG0439	Biotin carboxylase
CG474_010125	COG0511	ligase activity, forming carbon-carbon bonds
CG474_010130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CG474_010135	COG1024	Enoyl-CoA hydratase
CG474_010140	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CG474_010145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CG474_010155	COG1216	Glycosyl transferase, family 2
CG474_010160	COG0640	Transcriptional regulator
CG474_010175	COG1686	Belongs to the peptidase S11 family
CG474_010180	COG5002	protein histidine kinase activity
CG474_010210	COG0789	Transcriptional regulator
CG474_010235	COG0745	RESPONSE REGULATOR receiver
CG474_010255	COG2002	toxin-antitoxin pair type II binding
CG474_010260	COG3773	Cell wall hydrolase
CG474_010260	COG3409	Peptidoglycan-binding domain 1 protein
CG474_010275	COG0693	protein deglycase activity
CG474_010280	COG0201	protein transport
CG474_010300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CG474_010305	COG0322	excinuclease ABC activity
CG474_010320	COG4667	esterase of the alpha-beta hydrolase superfamily
CG474_010360	COG2223	nitrite transmembrane transporter activity
CG474_010410	COG1216	Glycosyl transferase, family 2
CG474_010425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG474_010430	COG1279	arginine transmembrane transporter activity
CG474_010470	COG1794	racemase activity, acting on amino acids and derivatives
CG474_010480	COG2828	Protein conserved in bacteria
CG474_010485	COG5002	protein histidine kinase activity
CG474_010490	COG0561	phosphatase activity
CG474_010510	COG2124	cytochrome p450
CG474_010555	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CG474_010585	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CG474_010590	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG474_010600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG474_010610	COG2959	enzyme of heme biosynthesis
CG474_010615	COG3409	Peptidoglycan-binding domain 1 protein
CG474_010615	COG3773	Cell wall hydrolase
CG474_010640	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CG474_010645	COG3844	kynureninase activity
CG474_010655	COG1028	Short-chain dehydrogenase reductase Sdr
CG474_010665	COG4176	ABC-type proline glycine betaine transport system permease component
CG474_010670	COG0517	IMP dehydrogenase activity
CG474_010670	COG4175	Glycine betaine
CG474_010700	COG2153	protein acetylation
CG474_010725	COG0514	ATP-dependent DNA helicase (RecQ)
CG474_010745	COG4637	Psort location Cytoplasmic, score
CG474_010750	COG1227	inorganic diphosphatase activity
CG474_010760	COG3397	chitin binding
CG474_010800	COG4166	transmembrane transport
CG474_010810	COG4948	Mandelate Racemase Muconate Lactonizing
CG474_010880	COG1307	EDD domain protein, DegV family
CG474_010950	COG2261	transglycosylase associated protein
CG474_010970	COG2826	transposase and inactivated derivatives, IS30 family
CG474_010985	COG0436	Aminotransferase
CG474_011000	COG3973	AAA domain
CG474_011010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG474_011035	COG0628	permease
CG474_011050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CG474_011055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG474_011060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CG474_011075	COG2746	aminoglycoside 3-N-acetyltransferase activity
CG474_011095	COG0454	-acetyltransferase
CG474_011095	COG0456	acetyltransferase
CG474_011105	COG0726	polysaccharide deacetylase
CG474_011110	COG3037	sugar-specific permease SgaT UlaA
CG474_011120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG474_011125	COG1368	sulfuric ester hydrolase activity
CG474_011130	COG0488	(ABC) transporter
CG474_011135	COG1605	Chorismate mutase
CG474_011135	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CG474_011155	COG0346	lactoylglutathione lyase activity
CG474_011165	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CG474_011170	COG1518	maintenance of DNA repeat elements
CG474_011210	COG2329	Antibiotic biosynthesis monooxygenase
CG474_011225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG474_011250	COG0494	nUDIX hydrolase
CG474_011265	COG0456	acetyltransferase
CG474_011270	COG0477	Major facilitator Superfamily
CG474_011285	COG0697	spore germination
CG474_011290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG474_011300	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CG474_011315	COG0730	response to heat
CG474_011325	COG0833	amino acid
CG474_011345	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CG474_011360	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CG474_011365	COG1984	allophanate hydrolase subunit 2
CG474_011370	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CG474_011375	COG1414	Transcriptional regulator
CG474_011390	COG1960	acyl-CoA dehydrogenase activity
CG474_011420	COG0346	lactoylglutathione lyase activity
CG474_011430	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CG474_011435	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CG474_011440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CG474_011445	COG0438	transferase activity, transferring glycosyl groups
CG474_011460	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG474_011465	COG0438	transferase activity, transferring glycosyl groups
CG474_011470	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG474_011480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CG474_011500	COG4851	CamS sex pheromone cAM373 precursor
CG474_011600	COG0477	Major facilitator Superfamily
CG474_011615	COG1846	Transcriptional regulator
CG474_011620	COG2814	Major facilitator Superfamily
CG474_011630	COG2031	fatty acid transporter
CG474_011660	COG1122	ATPase activity
CG474_011665	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CG474_011685	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CG474_011700	COG1131	(ABC) transporter
CG474_011760	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CG474_011765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG474_011770	COG0579	oxidoreductase
CG474_011775	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CG474_011785	COG1253	flavin adenine dinucleotide binding
CG474_011790	COG0789	Transcriptional regulator
CG474_011795	COG3813	Protein conserved in bacteria
CG474_011810	COG0384	phenazine biosynthesis protein PhzF
CG474_011875	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CG474_011920	COG0577	efflux transmembrane transporter activity
CG474_011920	COG1136	(ABC) transporter
CG474_011990	COG0577	efflux transmembrane transporter activity
CG474_011990	COG1136	(ABC) transporter
CG474_012045	COG2072	flavoprotein involved in K transport
CG474_012070	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CG474_012075	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CG474_012090	COG1193	negative regulation of DNA recombination
CG474_012100	COG1164	Oligoendopeptidase f
CG474_012120	COG0584	glycerophosphoryl diester phosphodiesterase
CG474_012125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG474_012155	COG3397	chitin binding
CG474_012165	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CG474_012170	COG0277	FAD linked oxidase domain protein
CG474_012175	COG1285	pathogenesis
CG474_012180	COG2720	vancomycin resistance protein
CG474_012215	COG4824	toxin secretion phage lysis holin
CG474_012325	COG0270	DNA (cytosine-5-)-methyltransferase activity
CG474_012370	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CG474_012390	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CG474_012390	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CG474_012460	COG1484	DNA-dependent DNA replication
CG474_012500	COG0582	viral genome integration into host DNA
CG474_012525	COG1278	Cold shock
CG474_012535	COG1028	Short-chain dehydrogenase reductase Sdr
CG474_012540	COG0165	Argininosuccinate lyase
CG474_012555	COG3409	Peptidoglycan-binding domain 1 protein
CG474_012570	COG4145	pantothenate transmembrane transporter activity
CG474_012575	COG3924	membrane
CG474_012580	COG1012	belongs to the aldehyde dehydrogenase family
CG474_012595	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CG474_012600	COG2962	Rard protein
CG474_012635	COG2226	methyltransferase
CG474_012640	COG4166	transmembrane transport
CG474_012645	COG4166	transmembrane transport
CG474_012650	COG1301	dicarboxylic acid transport
CG474_012655	COG0673	inositol 2-dehydrogenase activity
CG474_012660	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CG474_012665	COG0187	DNA topoisomerase II activity
CG474_012675	COG1832	CoA-binding protein
CG474_012680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CG474_012685	COG0745	RESPONSE REGULATOR receiver
CG474_012700	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CG474_012705	COG4841	protein insertion into membrane
CG474_012710	COG0824	Thioesterase
CG474_012740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG474_012745	COG3655	Transcriptional regulator
CG474_012765	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CG474_012775	COG0726	polysaccharide deacetylase
CG474_012805	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CG474_012810	COG0318	PFAM AMP-dependent synthetase and ligase
CG474_012840	COG0457	Tetratricopeptide repeat
CG474_012920	COG2826	transposase and inactivated derivatives, IS30 family
CG474_012935	COG0534	Mate efflux family protein
CG474_012965	COG3023	N-Acetylmuramoyl-L-alanine amidase
CG474_012975	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG474_012985	COG5002	protein histidine kinase activity
CG474_012990	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG474_012995	COG0010	Belongs to the arginase family
CG474_013000	COG1228	amidohydrolase
CG474_013005	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CG474_013010	COG2986	histidine ammonia-lyase
CG474_013035	COG4846	Membrane protein involved in cytochrome C biogenesis
CG474_013040	COG0785	Cytochrome C biogenesis protein
CG474_013055	COG0583	DNA-binding transcription factor activity
CG474_013060	COG1380	Effector of murein hydrolase LrgA
CG474_013065	COG1346	cytolysis
CG474_013070	COG4187	Peptidase family M20/M25/M40
CG474_013080	COG0833	amino acid
CG474_013090	COG0730	response to heat
CG474_013100	COG3409	Peptidoglycan-binding domain 1 protein
CG474_013100	COG5632	N-Acetylmuramoyl-L-alanine amidase
CG474_013115	COG1132	(ABC) transporter
CG474_013120	COG1132	(ABC) transporter
CG474_013125	COG3763	UPF0154 protein
CG474_013140	COG3639	organic phosphonate transmembrane transporter activity
CG474_013145	COG3639	organic phosphonate transmembrane transporter activity
CG474_013160	COG0737	Belongs to the 5'-nucleotidase family
CG474_013165	COG4224	UPF0291 protein
CG474_013170	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CG474_013175	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CG474_013190	COG1695	Transcriptional regulator
CG474_013230	COG3328	transposase activity
CG474_013235	COG3328	transposase activity
CG474_013245	COG1598	PFAM Uncharacterised protein family UPF0150
CG474_013255	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG474_013280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG474_013300	COG0730	response to heat
CG474_013370	COG0174	glutamine synthetase
CG474_013375	COG0789	Transcriptional regulator
CG474_013380	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CG474_013385	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CG474_013390	COG2860	membrane
CG474_013395	COG0464	growth
CG474_013410	COG1923	regulation of RNA biosynthetic process
CG474_013415	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CG474_013425	COG3584	3D domain protein
CG474_013425	COG1388	LysM domain
CG474_013430	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG474_013430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG474_013430	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG474_013435	COG1105	Belongs to the carbohydrate kinase PfkB family
CG474_013440	COG1349	DNA-binding transcription factor activity
CG474_013445	COG2322	membrane
CG474_013470	COG2116	formate transmembrane transporter activity
CG474_013480	COG1937	Protein conserved in bacteria
CG474_013485	COG2819	hydrolase of the alpha beta superfamily
CG474_013490	COG1120	ATPase activity
CG474_013495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG474_013500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG474_013505	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG474_013510	COG2706	6-phosphogluconolactonase activity
CG474_013515	COG2195	Cleaves the N-terminal amino acid of tripeptides
CG474_013525	COG0346	lactoylglutathione lyase activity
CG474_013540	COG1113	amino acid transport
CG474_013565	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CG474_013570	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CG474_013580	COG4550	Control of competence regulator ComK, YlbF/YmcA
CG474_013585	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CG474_013590	COG1013	pyruvate-flavodoxin oxidoreductase activity
CG474_013595	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CG474_013595	COG0674	pyruvate-flavodoxin oxidoreductase activity
CG474_013605	COG2359	stage V sporulation protein S
CG474_013610	COG1692	metallophosphoesterase
CG474_013615	COG1418	mRNA catabolic process
CG474_013620	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CG474_013625	COG1546	Belongs to the CinA family
CG474_013625	COG1058	Belongs to the CinA family
CG474_013630	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CG474_013635	COG1426	Protein conserved in bacteria
CG474_013655	COG0300	oxidoreductase activity
CG474_013660	COG0612	Peptidase, M16
CG474_013665	COG0612	Peptidase, M16
CG474_013690	COG2188	Transcriptional regulator
CG474_013695	COG1674	ftsk spoiiie
CG474_013710	COG0740	serine-type endopeptidase activity
CG474_013735	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CG474_013755	COG0527	aspartate kinase activity
CG474_013760	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CG474_013765	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CG474_013770	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CG474_013775	COG1873	PFAM PRC-barrel domain
CG474_013780	COG0612	Peptidase, M16
CG474_013785	COG0726	polysaccharide deacetylase
CG474_013790	COG1185	polyribonucleotide nucleotidyltransferase activity
CG474_013800	COG0196	riboflavin kinase activity
CG474_013805	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CG474_013810	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CG474_013815	COG1550	Protein conserved in bacteria
CG474_013820	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CG474_013825	COG1358	cellular component organization or biogenesis
CG474_013830	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CG474_013835	COG0195	Participates in both transcription termination and antitermination
CG474_013840	COG0779	Required for maturation of 30S ribosomal subunits
CG474_013850	COG0442	prolyl-tRNA aminoacylation
CG474_013855	COG0750	zinc metalloprotease
CG474_013865	COG4589	Belongs to the CDS family
CG474_013875	COG0233	cytoplasmic translational termination
CG474_013880	COG0528	UMP kinase activity
CG474_013885	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CG474_013890	COG0052	Belongs to the universal ribosomal protein uS2 family
CG474_013895	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CG474_013900	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CG474_013905	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CG474_013910	COG4974	Belongs to the 'phage' integrase family
CG474_013915	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CG474_013920	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CG474_013925	COG0758	DNA mediated transformation
CG474_013930	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CG474_013935	COG0045	succinate-CoA ligase (ADP-forming) activity
CG474_013940	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CG474_013955	COG0335	large ribosomal subunit rRNA binding
CG474_013965	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CG474_013970	COG1837	Belongs to the UPF0109 family
CG474_013975	COG0228	four-way junction DNA binding
CG474_013980	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CG474_013985	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CG474_013990	COG0552	protein localization to endoplasmic reticulum
CG474_013995	COG1196	nuclear chromosome segregation
CG474_014000	COG0571	ribonuclease III activity
CG474_014010	COG1028	Short-chain dehydrogenase reductase Sdr
CG474_014015	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CG474_014020	COG0416	fatty acid biosynthetic process
CG474_014025	COG2050	protein possibly involved in aromatic compounds catabolism
CG474_014025	COG1349	DNA-binding transcription factor activity
CG474_014030	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CG474_014035	COG1461	Dihydroxyacetone kinase
CG474_014040	COG1302	Protein conserved in bacteria
CG474_014045	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CG474_014055	COG1564	THIamine pyrophosphokinase
CG474_014060	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CG474_014065	COG1162	GTPase activity
CG474_014070	COG2815	serine threonine protein kinase
CG474_014070	COG0515	serine threonine protein kinase
CG474_014075	COG0631	protein serine/threonine phosphatase activity
CG474_014080	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CG474_014085	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CG474_014085	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CG474_014090	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CG474_014095	COG0242	peptide deformylase activity
CG474_014100	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CG474_014110	COG1758	RNA polymerase activity
CG474_014115	COG0194	GDP metabolic process
CG474_014125	COG1561	YicC-like family, N-terminal region
CG474_014130	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CG474_014155	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CG474_014160	COG0284	orotidine-5'-phosphate decarboxylase activity
CG474_014165	COG0167	dihydroorotate dehydrogenase activity
CG474_014170	COG0543	2 iron, 2 sulfur cluster binding
CG474_014175	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CG474_014185	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CG474_014190	COG0540	Belongs to the ATCase OTCase family
CG474_014200	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CG474_014210	COG0564	pseudouridine synthase activity
CG474_014215	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CG474_014225	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CG474_014230	COG3599	regulation of cell shape
CG474_014235	COG2302	S4 RNA-binding domain
CG474_014240	COG0762	integral membrane protein
CG474_014245	COG1799	cell septum assembly
CG474_014250	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CG474_014260	COG1873	PFAM PRC-barrel domain
CG474_014265	COG1191	sigma factor activity
CG474_014270	COG1191	sigma factor activity
CG474_014280	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CG474_014285	COG0849	cell division
CG474_014290	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CG474_014300	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CG474_014305	COG0772	Belongs to the SEDS family
CG474_014310	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CG474_014315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CG474_014320	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CG474_014325	COG0768	penicillin binding
CG474_014335	COG4839	cell division protein FtsL
CG474_014340	COG0275	rRNA processing
CG474_014345	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CG474_014350	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CG474_014370	COG1399	metal-binding, possibly nucleic acid-binding protein
CG474_014375	COG1323	Belongs to the UPF0348 family
CG474_014380	COG3480	Lon protease (S16) C-terminal proteolytic domain
CG474_014385	COG1752	Esterase of the alpha-beta hydrolase superfamily
CG474_014390	COG3314	Sporulation integral membrane protein YlbJ
CG474_014395	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CG474_014400	COG0742	ribosomal rna small subunit methyltransferase
CG474_014410	COG4471	UPF0298 protein
CG474_014415	COG3679	Belongs to the UPF0342 family
CG474_014420	COG0406	alpha-ribazole phosphatase activity
CG474_014435	COG2340	Cysteine-rich secretory protein family
CG474_014445	COG3336	cytochrome c oxidase
CG474_014470	COG0109	protoheme IX farnesyltransferase activity
CG474_014475	COG1612	heme a metabolic process
CG474_014480	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CG474_014490	COG0772	Belongs to the SEDS family
CG474_014495	COG4838	Belongs to the UPF0358 family
CG474_014500	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CG474_014505	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CG474_014515	COG4896	Protein conserved in bacteria
CG474_014540	COG0483	inositol monophosphate 1-phosphatase activity
CG474_014550	COG4493	Belongs to the UPF0637 family
CG474_014555	COG4476	Belongs to the UPF0223 family
CG474_014600	COG0508	dehydrogenase complex catalyzes the overall conversion of
CG474_014610	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CG474_014625	COG0561	phosphatase activity
CG474_014640	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CG474_014645	COG0569	domain protein
CG474_014655	COG1473	amidohydrolase
CG474_014660	COG2171	N-acyltransferase activity
CG474_014665	COG0583	DNA-binding transcription factor activity
CG474_014670	COG0517	IMP dehydrogenase activity
CG474_014680	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CG474_014690	COG4703	Protein of unknown function (DUF1797)
CG474_014705	COG2200	EAL domain
CG474_014710	COG1028	Short-chain dehydrogenase reductase Sdr
CG474_014715	COG1408	metallophosphoesterase
CG474_014725	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CG474_014745	COG0726	polysaccharide deacetylase
CG474_014765	COG2814	Major facilitator Superfamily
CG474_014770	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CG474_014780	COG3209	COG3209 Rhs family protein
CG474_014790	COG2205	protein histidine kinase activity
CG474_014800	COG0436	Aminotransferase
CG474_014805	COG1609	Transcriptional regulator
CG474_014840	COG0183	Belongs to the thiolase family
CG474_014870	COG1695	Transcriptional regulator
CG474_014875	COG1028	Short-chain dehydrogenase reductase Sdr
CG474_014885	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CG474_014890	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CG474_014895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CG474_014900	COG0436	Aminotransferase
CG474_014905	COG1850	ribulose-bisphosphate carboxylase activity
CG474_014910	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
CG474_014915	COG0235	Class ii aldolase
CG474_014920	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CG474_014935	COG2084	Dehydrogenase
CG474_014950	COG0778	Nitroreductase
CG474_014975	COG1263	PTS System
CG474_014975	COG2190	(PTS) system
CG474_014975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG474_014980	COG3711	transcriptional antiterminator
CG474_014995	COG0363	glucosamine-6-phosphate deaminase activity
CG474_015010	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CG474_015015	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CG474_015025	COG1547	Domain of unknown function (DUF309)
CG474_015035	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CG474_015040	COG4086	secreted protein
CG474_015045	COG0561	phosphatase activity
CG474_015050	COG0697	spore germination
CG474_015065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CG474_015090	COG0733	neurotransmitter:sodium symporter activity
CG474_015100	COG2172	sigma factor antagonist activity
CG474_015110	COG1686	Belongs to the peptidase S11 family
CG474_015120	COG1725	Transcriptional regulator
CG474_015125	COG1131	(ABC) transporter
CG474_015145	COG1846	Transcriptional regulator
CG474_015160	COG0598	Magnesium transport protein CorA
CG474_015185	COG4974	Belongs to the 'phage' integrase family
CG474_015195	COG0735	belongs to the Fur family
CG474_015200	COG1300	Membrane
CG474_015220	COG0667	Aldo Keto reductase
CG474_015225	COG0656	L-ascorbic acid biosynthetic process
CG474_015230	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CG474_015230	COG0456	acetyltransferase
CG474_015240	COG0737	Belongs to the 5'-nucleotidase family
CG474_015240	COG4085	toxin activity
CG474_015240	COG1525	nuclease
CG474_015250	COG0596	Alpha beta hydrolase
CG474_015255	COG2056	Na+-H+ antiporter family
CG474_015260	COG1609	Transcriptional regulator
CG474_015265	COG0456	acetyltransferase
CG474_015270	COG1073	alpha beta
CG474_015285	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CG474_015285	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CG474_015290	COG0307	riboflavin synthase, alpha
CG474_015295	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CG474_015295	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CG474_015310	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CG474_015315	COG4106	trans-aconitate 2-methyltransferase activity
CG474_015320	COG0596	Alpha beta hydrolase
CG474_015325	COG0156	8-amino-7-oxononanoate synthase activity
CG474_015335	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CG474_015350	COG0737	Belongs to the 5'-nucleotidase family
CG474_015375	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CG474_015385	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CG474_015395	COG0300	oxidoreductase activity
CG474_015400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG474_015405	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CG474_015410	COG1760	l-serine dehydratase
CG474_015415	COG1760	l-serine dehydratase
CG474_015425	COG1234	tRNA 3'-trailer cleavage
CG474_015445	COG2195	Cleaves the N-terminal amino acid of tripeptides
CG474_015450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG474_015465	COG1376	ErfK ybiS ycfS ynhG family protein
CG474_015470	COG4129	membrane
CG474_015475	COG1126	abc transporter atp-binding protein
CG474_015480	COG0765	amino acid transport
CG474_015485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG474_015500	COG2816	NAD+ diphosphatase activity
CG474_015505	COG0772	Belongs to the SEDS family
CG474_015515	COG0508	dehydrogenase complex catalyzes the overall conversion of
CG474_015520	COG0022	dehydrogenase e1 component
CG474_015525	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CG474_015530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CG474_015535	COG3426	butyrate kinase activity
CG474_015540	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CG474_015545	COG0280	phosphate acetyltransferase
CG474_015555	COG3290	protein histidine kinase activity
CG474_015555	COG3829	transcription factor binding
CG474_015565	COG0584	glycerophosphoryl diester phosphodiesterase
CG474_015570	COG3093	addiction module antidote protein HigA
CG474_015575	COG0745	RESPONSE REGULATOR receiver
CG474_015585	COG0750	zinc metalloprotease
CG474_015590	COG0497	DNA recombination
CG474_015600	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CG474_015605	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CG474_015615	COG1722	exodeoxyribonuclease VII activity
CG474_015620	COG1570	exodeoxyribonuclease VII activity
CG474_015625	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CG474_015630	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CG474_015635	COG1302	Protein conserved in bacteria
CG474_015640	COG0439	Biotin carboxylase
CG474_015645	COG0511	ligase activity, forming carbon-carbon bonds
CG474_015690	COG3854	ATPases associated with a variety of cellular activities
CG474_015710	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CG474_015715	COG0006	proline dipeptidase activity
CG474_015720	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CG474_015730	COG3872	metal-dependent enzyme
CG474_015740	COG1321	iron dependent repressor
CG474_015755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CG474_015765	COG1609	Transcriptional regulator
CG474_015775	COG2076	Multidrug Resistance protein
CG474_015780	COG2076	Multidrug Resistance protein
CG474_015805	COG1131	(ABC) transporter
CG474_015810	COG1725	Transcriptional regulator
CG474_015825	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CG474_015830	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CG474_015835	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CG474_015840	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CG474_015870	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CG474_015895	COG1459	type II secretion system
CG474_015920	COG4824	toxin secretion phage lysis holin
CG474_016000	COG3728	DNA packaging
CG474_016010	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CG474_016130	COG1396	sequence-specific DNA binding
CG474_016145	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CG474_016180	COG1078	dGTPase activity
CG474_016195	COG1410	methionine synthase
CG474_016195	COG0646	methionine synthase
CG474_016200	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CG474_016200	COG0646	methionine synthase
CG474_016205	COG0626	cystathionine gamma-synthase activity
CG474_016210	COG0626	cystathionine gamma-synthase activity
CG474_016230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG474_016240	COG1940	carbohydrate kinase activity
CG474_016245	COG4483	Protein conserved in bacteria
CG474_016250	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CG474_016255	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CG474_016260	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CG474_016265	COG0704	Plays a role in the regulation of phosphate uptake
CG474_016270	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CG474_016275	COG0581	inorganic phosphate transmembrane transporter activity
CG474_016280	COG0573	inorganic phosphate transmembrane transporter activity
CG474_016285	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CG474_016295	COG0477	Major facilitator Superfamily
CG474_016300	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CG474_016320	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CG474_016325	COG0735	belongs to the Fur family
CG474_016330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CG474_016335	COG1121	(ABC) transporter
CG474_016340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG474_016350	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CG474_016365	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CG474_016370	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CG474_016375	COG2384	SAM-dependent methyltransferase
CG474_016385	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CG474_016390	COG0358	DNA primase activity
CG474_016395	COG1671	Belongs to the UPF0178 family
CG474_016400	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CG474_016405	COG0517	IMP dehydrogenase activity
CG474_016410	COG1381	Involved in DNA repair and RecF pathway recombination
CG474_016420	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CG474_016430	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CG474_016435	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CG474_016440	COG1480	7TM receptor with intracellular HD hydrolase
CG474_016445	COG1702	phosphate starvation-inducible protein PhoH
CG474_016460	COG1610	YqeY-like protein
CG474_016465	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CG474_016470	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CG474_016475	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CG474_016480	COG2264	protein methyltransferase activity
CG474_016485	COG0484	heat shock protein binding
CG474_016490	COG0443	Heat shock 70 kDa protein
CG474_016495	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CG474_016500	COG1420	regulation of RNA biosynthetic process
CG474_016505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CG474_016510	COG1733	regulation of RNA biosynthetic process
CG474_016515	COG0693	protein deglycase activity
CG474_016520	COG0481	GTPase activity
CG474_016530	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CG474_016535	COG0268	Binds directly to 16S ribosomal RNA
CG474_016540	COG1466	dna polymerase III delta subunit
CG474_016550	COG0658	competence protein
CG474_016550	COG2333	competence protein COMEC
CG474_016555	COG2131	deaminase
CG474_016560	COG1555	photosystem II stabilization
CG474_016560	COG1596	polysaccharide export
CG474_016565	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CG474_016570	COG2226	methyltransferase
CG474_016575	COG0799	negative regulation of ribosome biogenesis
CG474_016580	COG1713	HD superfamily hydrolase involved in NAD metabolism
CG474_016585	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CG474_016590	COG1534	Rna-binding protein
CG474_016595	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CG474_016600	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CG474_016605	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CG474_016615	COG0688	phosphatidylethanolamine metabolic process
CG474_016620	COG1191	sigma factor activity
CG474_016630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CG474_016635	COG2357	RelA SpoT domain protein
CG474_016640	COG1785	Belongs to the alkaline phosphatase family
CG474_016645	COG0456	acetyltransferase
CG474_016650	COG2267	carboxylic ester hydrolase activity
CG474_016675	COG3186	Phenylalanine-4-hydroxylase
CG474_016680	COG2154	pterin-4-alpha-carbinolamine dehydratase
CG474_016685	COG2514	catechol 2,3-dioxygenase activity
CG474_016690	COG2259	Doxx family
CG474_016710	COG1609	Transcriptional regulator
CG474_016720	COG0626	cystathionine gamma-synthase activity
CG474_016725	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CG474_016730	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CG474_016735	COG2226	methyltransferase
CG474_016755	COG0768	penicillin binding
CG474_016765	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CG474_016770	COG0572	uridine kinase
CG474_016790	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CG474_016800	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CG474_016805	COG4472	Bacterial protein of unknown function (DUF965)
CG474_016810	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CG474_016815	COG0628	permease
CG474_016835	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CG474_016845	COG0482	sulfurtransferase activity
CG474_016850	COG1104	cysteine desulfurase activity
CG474_016855	COG1959	2 iron, 2 sulfur cluster binding
CG474_016860	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CG474_016880	COG2207	Transcriptional regulator
CG474_016890	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CG474_016895	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CG474_016900	COG0124	histidyl-tRNA synthetase
CG474_016920	COG1490	D-aminoacyl-tRNA deacylase activity
CG474_016925	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CG474_016930	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CG474_016935	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CG474_016935	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CG474_016940	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CG474_016945	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CG474_016945	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CG474_016955	COG2244	polysaccharide biosynthetic process
CG474_016980	COG1862	Preprotein translocase
CG474_016985	COG0343	queuine tRNA-ribosyltransferase activity
CG474_016990	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CG474_017000	COG2255	four-way junction helicase activity
CG474_017005	COG0632	four-way junction helicase activity
CG474_017010	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CG474_017030	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CG474_017035	COG0157	Belongs to the NadC ModD family
CG474_017040	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CG474_017045	COG1104	cysteine desulfurase activity
CG474_017050	COG1827	regulation of RNA biosynthetic process
CG474_017055	COG2258	MOSC domain
CG474_017060	COG0077	Prephenate dehydratase
CG474_017065	COG0577	efflux transmembrane transporter activity
CG474_017070	COG0577	efflux transmembrane transporter activity
CG474_017075	COG1136	(ABC) transporter
CG474_017080	COG5002	protein histidine kinase activity
CG474_017085	COG0745	RESPONSE REGULATOR receiver
CG474_017095	COG3290	protein histidine kinase activity
CG474_017100	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CG474_017105	COG2868	ribosomal protein
CG474_017115	COG1530	ribonuclease E activity
CG474_017120	COG1994	Peptidase M50
CG474_017125	COG0739	heme binding
CG474_017130	COG2894	cell division
CG474_017145	COG1792	Involved in formation and maintenance of cell shape
CG474_017150	COG1077	Cell shape determining protein MreB Mrl
CG474_017170	COG0424	maF-like protein
CG474_017180	COG0285	dihydrofolate synthase activity
CG474_017205	COG1388	LysM domain
CG474_017205	COG1388	LysM domain
CG474_017210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CG474_017215	COG0113	porphobilinogen synthase activity
CG474_017220	COG1587	Uroporphyrinogen-III synthase
CG474_017225	COG0181	hydroxymethylbilane synthase activity
CG474_017230	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CG474_017235	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CG474_017240	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CG474_017250	COG0470	DNA polymerase III
CG474_017250	COG1067	ATP-dependent peptidase activity
CG474_017255	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CG474_017260	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG474_017285	COG4221	oxidoreductase activity
CG474_017285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CG474_017285	COG3321	synthase
CG474_017285	COG1028	Short-chain dehydrogenase reductase Sdr
CG474_017300	COG1033	growth of symbiont in host cell
CG474_017300	COG2409	Drug exporters of the RND superfamily
CG474_017315	COG1309	transcriptional regulator
CG474_017335	COG0622	Phosphoesterase
CG474_017345	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CG474_017350	COG5401	PFAM Sporulation and spore germination
CG474_017360	COG2197	response regulator
CG474_017400	COG2197	response regulator
CG474_017410	COG1959	2 iron, 2 sulfur cluster binding
CG474_017415	COG1668	transmembrane transport
CG474_017420	COG4152	abc transporter atp-binding protein
CG474_017425	COG1360	Flagellar Motor Protein
CG474_017430	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CG474_017440	COG1876	peptidase activity
CG474_017450	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CG474_017455	COG1053	succinate dehydrogenase
CG474_017460	COG2009	succinate dehydrogenase
CG474_017465	COG1719	4-vinyl reductase, 4VR
CG474_017480	COG3118	belongs to the thioredoxin family
CG474_017485	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CG474_017490	COG2086	electron transfer activity
CG474_017495	COG1024	Enoyl-CoA hydratase
CG474_017500	COG1309	transcriptional regulator
CG474_017505	COG0318	PFAM AMP-dependent synthetase and ligase
CG474_017515	COG2318	DinB family
CG474_017535	COG1131	(ABC) transporter
CG474_017540	COG2205	protein histidine kinase activity
CG474_017545	COG0745	RESPONSE REGULATOR receiver
CG474_017555	COG4895	conserved protein (DUF2196)
CG474_017560	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CG474_017565	COG1114	Component of the transport system for branched-chain amino acids
CG474_017570	COG1187	pseudouridine synthase activity
CG474_017580	COG1193	negative regulation of DNA recombination
CG474_017585	COG1796	DNA polymerase
CG474_017585	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CG474_017590	COG1286	toxin biosynthetic process
CG474_017595	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CG474_017620	COG0017	Asparaginyl-tRNA synthetase
CG474_017625	COG0072	phenylalanine-tRNA ligase activity
CG474_017625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CG474_017630	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CG474_017635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CG474_017645	COG1418	mRNA catabolic process
CG474_017660	COG2814	Major facilitator Superfamily
CG474_017665	COG1566	PFAM secretion protein HlyD family protein
CG474_017670	COG1309	transcriptional regulator
CG474_017675	COG1363	Peptidase, m42
CG474_017685	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CG474_017690	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CG474_017695	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CG474_017700	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CG474_017710	COG1484	DNA-dependent DNA replication
CG474_017720	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CG474_017725	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CG474_017735	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CG474_017745	COG1971	Probably functions as a manganese efflux pump
CG474_017755	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CG474_017755	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CG474_017760	COG5002	protein histidine kinase activity
CG474_017765	COG0745	RESPONSE REGULATOR receiver
CG474_017775	COG0039	L-malate dehydrogenase activity
CG474_017780	COG0538	isocitrate dehydrogenase activity
CG474_017785	COG0372	Belongs to the citrate synthase family
CG474_017790	COG2707	UPF0756 membrane protein
CG474_017795	COG0628	permease
CG474_017800	COG3030	protein affecting phage T7 exclusion by the F plasmid
CG474_017810	COG0205	6-phosphofructokinase activity
CG474_017815	COG0825	malonyl-CoA metabolic process
CG474_017820	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CG474_017825	COG1725	Transcriptional regulator
CG474_017830	COG0281	malic enzyme
CG474_017835	COG0587	DNA-directed DNA polymerase activity
CG474_017850	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CG474_017860	COG4109	DRTGG domain
CG474_017865	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CG474_017870	COG0006	proline dipeptidase activity
CG474_017895	COG1028	Short-chain dehydrogenase reductase Sdr
CG474_017900	COG0589	response to stress
CG474_017925	COG0165	Argininosuccinate lyase
CG474_017930	COG0137	argininosuccinate synthase activity
CG474_017940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG474_017950	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CG474_017955	COG0827	DNA restriction-modification system
CG474_017960	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CG474_017965	COG3874	Sporulation protein YtfJ
CG474_017975	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CG474_017980	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CG474_017985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CG474_017995	COG0301	tRNA thio-modification
CG474_018000	COG1104	cysteine desulfurase activity
CG474_018005	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CG474_018010	COG0583	DNA-binding transcription factor activity
CG474_018015	COG0697	spore germination
CG474_018020	COG1309	transcriptional regulator
CG474_018025	COG1956	GAF domain-containing protein
CG474_018030	COG0626	cystathionine gamma-synthase activity
CG474_018040	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CG474_018060	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CG474_018070	COG1595	DNA-templated transcription, initiation
CG474_018080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CG474_018085	COG0454	-acetyltransferase
CG474_018090	COG0517	IMP dehydrogenase activity
CG474_018095	COG0123	including yeast histone deacetylase and acetoin utilization protein
CG474_018100	COG1970	mechanosensitive ion channel activity
CG474_018110	COG1609	Transcriptional regulator
CG474_018120	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CG474_018120	COG1605	Chorismate mutase
CG474_018125	COG3118	belongs to the thioredoxin family
CG474_018135	COG2309	aminopeptidase activity
CG474_018150	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CG474_018160	COG1674	ftsk spoiiie
CG474_018170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CG474_018175	COG4848	Belongs to the UPF0354 family
CG474_018180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG474_018185	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CG474_018195	COG0675	Transposase, IS605 OrfB family
CG474_018205	COG1363	Peptidase, m42
CG474_018215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG474_018220	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CG474_018230	COG0510	thiamine kinase activity
CG474_018235	COG1523	belongs to the glycosyl hydrolase 13 family
CG474_018245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CG474_018250	COG1349	DNA-binding transcription factor activity
CG474_018255	COG1187	pseudouridine synthase activity
CG474_018260	COG2244	polysaccharide biosynthetic process
CG474_018265	COG2081	HI0933 family
CG474_018270	COG2814	Major facilitator Superfamily
CG474_018280	COG3832	glyoxalase III activity
CG474_018300	COG0463	Glycosyl transferase, family 2
CG474_018360	COG1329	Transcriptional regulator
CG474_018370	COG2223	nitrite transmembrane transporter activity
CG474_018380	COG0314	molybdopterin synthase activity
CG474_018385	COG1763	Mo-molybdopterin cofactor biosynthetic process
CG474_018390	COG0303	'Molybdopterin
CG474_018395	COG0315	cyclic pyranopterin monophosphate synthase activity
CG474_018400	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG474_018405	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CG474_018410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CG474_018415	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CG474_018420	COG1140	nitrate reductase beta subunit
CG474_018425	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CG474_018430	COG2181	nitrate reductase activity
CG474_018445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CG474_018455	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CG474_018490	COG0495	leucyl-tRNA aminoacylation
CG474_018495	COG2814	Major facilitator Superfamily
CG474_018505	COG1136	(ABC) transporter
CG474_018510	COG0346	lactoylglutathione lyase activity
CG474_018525	COG1242	4 iron, 4 sulfur cluster binding
CG474_018530	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CG474_018535	COG1121	(ABC) transporter
CG474_018545	COG1794	racemase activity, acting on amino acids and derivatives
CG474_018555	COG2378	regulation of single-species biofilm formation
CG474_018565	COG2267	carboxylic ester hydrolase activity
CG474_018570	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CG474_018580	COG0746	molybdenum cofactor guanylyltransferase activity
CG474_018605	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CG474_018615	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CG474_018660	COG5632	N-Acetylmuramoyl-L-alanine amidase
CG474_018660	COG3409	Peptidoglycan-binding domain 1 protein
CG474_018670	COG1368	sulfuric ester hydrolase activity
CG474_018685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CG474_018690	COG1116	anion transmembrane transporter activity
CG474_018695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG474_018710	COG0494	nUDIX hydrolase
CG474_018720	COG1854	S-ribosylhomocysteine lyase activity
CG474_018725	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CG474_018730	COG0288	reversible hydration of carbon dioxide
CG474_018735	COG1271	oxidase subunit
CG474_018740	COG1294	oxidase, subunit
CG474_018770	COG1842	Phage shock protein A
CG474_018815	COG1597	lipid kinase activity
CG474_018820	COG0586	Pfam SNARE associated Golgi protein
CG474_018825	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CG474_018830	COG1136	(ABC) transporter
CG474_018840	COG0745	RESPONSE REGULATOR receiver
CG474_018845	COG2205	protein histidine kinase activity
CG474_018850	COG0577	efflux transmembrane transporter activity
CG474_018855	COG1136	(ABC) transporter
CG474_018875	COG4948	Mandelate Racemase Muconate Lactonizing
CG474_018880	COG0318	PFAM AMP-dependent synthetase and ligase
CG474_018885	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CG474_018890	COG0596	Alpha beta hydrolase
CG474_018895	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CG474_018900	COG1169	isochorismate synthase
CG474_018905	COG1575	Belongs to the MenA family. Type 1 subfamily
CG474_018910	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CG474_018915	COG1278	Cold shock
CG474_018935	COG0058	SHG alpha-glucan phosphorylase activity
CG474_018940	COG0297	glycogen (starch) synthase activity
CG474_018945	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CG474_018950	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CG474_018955	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CG474_018960	COG0039	L-malate dehydrogenase activity
CG474_019055	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG474_019090	COG1285	pathogenesis
CG474_019095	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CG474_019105	COG0166	Belongs to the GPI family
CG474_019115	COG2155	Conserved Protein
CG474_019120	COG1098	S1 RNA binding domain
CG474_019125	COG0436	Aminotransferase
CG474_019130	COG1522	sequence-specific DNA binding
CG474_019135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CG474_019140	COG2267	carboxylic ester hydrolase activity
CG474_019150	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CG474_019155	COG2032	superoxide dismutase activity
CG474_019165	COG5018	Exonuclease
CG474_019170	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CG474_019175	COG0423	glycine-tRNA ligase activity
CG474_019190	COG2050	protein possibly involved in aromatic compounds catabolism
CG474_019200	COG1268	BioY protein
CG474_019205	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CG474_019210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CG474_019220	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CG474_019230	COG3584	3D domain protein
CG474_019250	COG1252	NADH dehydrogenase
CG474_019255	COG0492	ferredoxin-NADP+ reductase activity
CG474_019270	COG1683	Conserved Protein
CG474_019280	COG0316	Belongs to the HesB IscA family
CG474_019285	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CG474_019290	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG474_019300	COG1252	NADH dehydrogenase
CG474_019305	COG2824	Alkylphosphonate utilization operon protein PhnA
CG474_019315	COG3655	Transcriptional regulator
CG474_019330	COG4837	Protein of unknown function (DUF1462)
CG474_019335	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CG474_019340	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG474_019345	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CG474_019350	COG0647	UMP catabolic process
CG474_019360	COG2445	Protein of unknown function DUF86
CG474_019365	COG1494	fructose-1,6-bisphosphatase
CG474_019375	COG4470	Protein conserved in bacteria
CG474_019385	COG0789	Transcriptional regulator
CG474_019390	COG4377	Putative membrane peptidase family (DUF2324)
CG474_019405	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CG474_019410	COG0739	heme binding
CG474_019420	COG3377	Domain of unknown function (DUF1805)
CG474_019425	COG0737	Belongs to the 5'-nucleotidase family
CG474_019445	COG0719	Fe-S assembly protein
CG474_019450	COG0822	iron-sulfur transferase activity
CG474_019455	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CG474_019460	COG0719	Fe-S assembly protein
CG474_019465	COG0396	ATPase activity
CG474_019470	COG1464	Belongs to the NlpA lipoprotein family
CG474_019475	COG2011	ABC-type metal ion transport system permease component
CG474_019490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG474_019495	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CG474_019500	COG0509	glycine decarboxylation via glycine cleavage system
CG474_019505	COG1393	Belongs to the ArsC family
CG474_019550	COG1960	acyl-CoA dehydrogenase activity
CG474_019555	COG0183	Belongs to the thiolase family
CG474_019560	COG1024	Enoyl-CoA hydratase
CG474_019560	COG1250	3-hydroxyacyl-CoA dehydrogenase
CG474_019570	COG1686	Belongs to the peptidase S11 family
CG474_019595	COG0011	TIGRFAM Protein of
CG474_019600	COG0840	transmembrane signaling receptor activity
CG474_019620	COG0531	amino acid
CG474_019625	COG0706	membrane insertase activity
CG474_019635	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG474_019645	COG5002	protein histidine kinase activity
CG474_019650	COG0745	RESPONSE REGULATOR receiver
CG474_019665	COG1131	(ABC) transporter
CG474_019675	COG0586	Pfam SNARE associated Golgi protein
CG474_019685	COG1376	ErfK ybiS ycfS ynhG family protein
CG474_019695	COG5002	protein histidine kinase activity
CG474_019705	COG0840	transmembrane signaling receptor activity
CG474_019710	COG2151	metal-sulfur cluster biosynthetic enzyme
CG474_019715	COG3227	Zinc metalloprotease (Elastase)
CG474_019720	COG1741	Belongs to the pirin family
CG474_019735	COG0783	Belongs to the Dps family
CG474_019740	COG1611	Belongs to the LOG family
CG474_019765	COG0803	Belongs to the bacterial solute-binding protein 9 family
CG474_019770	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CG474_019775	COG1121	(ABC) transporter
CG474_019800	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG474_019805	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG474_019810	COG1115	amino acid carrier protein
CG474_019815	COG2910	NAD(P)H-binding
CG474_019830	COG1252	NADH dehydrogenase
CG474_019845	COG1595	DNA-templated transcription, initiation
CG474_019855	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CG474_019870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CG474_019875	COG4977	sequence-specific DNA binding
CG474_019875	COG1917	Cupin 2, conserved barrel domain protein
CG474_019885	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CG474_019905	COG0697	spore germination
CG474_019920	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CG474_019925	COG0557	exoribonuclease II activity
CG474_019930	COG1647	Serine aminopeptidase, S33
CG474_019935	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CG474_019940	COG1346	cytolysis
CG474_019950	COG0148	phosphopyruvate hydratase activity
CG474_019955	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CG474_019960	COG0149	triose-phosphate isomerase activity
CG474_019965	COG0126	phosphoglycerate kinase activity
CG474_019970	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CG474_019985	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CG474_020010	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CG474_020025	COG2323	membrane
CG474_020035	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG474_020040	COG1481	regulation of sporulation
CG474_020045	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CG474_020050	COG1660	Displays ATPase and GTPase activities
CG474_020055	COG1051	belongs to the nudix hydrolase family
CG474_020065	COG0492	ferredoxin-NADP+ reductase activity
CG474_020070	COG0457	Tetratricopeptide repeat
CG474_020075	COG0110	maltose O-acetyltransferase activity
CG474_020085	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CG474_020090	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CG474_020095	COG1950	PFAM Membrane protein of
CG474_020105	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CG474_020120	COG0789	Transcriptional regulator
CG474_020140	COG0583	DNA-binding transcription factor activity
CG474_020155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CG474_020160	COG3409	Peptidoglycan-binding domain 1 protein
CG474_020160	COG0793	Belongs to the peptidase S41A family
CG474_020165	COG2177	Part of the ABC transporter FtsEX involved in
CG474_020170	COG2884	Cell division ATP-binding protein ftsE
CG474_020205	COG1278	Cold shock
CG474_020210	COG1040	competence protein
CG474_020215	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CG474_020220	COG0791	NLP P60 protein
CG474_020220	COG1388	LysM domain
CG474_020225	COG1733	regulation of RNA biosynthetic process
CG474_020230	COG1307	EDD domain protein, DegV family
CG474_020235	COG1739	Uncharacterized protein family UPF0029
CG474_020240	COG1316	TRANSCRIPTIONal
CG474_020260	COG0457	Tetratricopeptide repeat
CG474_020290	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CG474_020300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CG474_020310	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CG474_020310	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CG474_020325	COG1486	melibiose metabolic process
CG474_020330	COG1447	Phosphotransferase system cellobiose-specific component IIA
CG474_020345	COG1447	Phosphotransferase system cellobiose-specific component IIA
CG474_020350	COG1301	dicarboxylic acid transport
CG474_020355	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CG474_020365	COG1271	oxidase subunit
CG474_020370	COG1294	oxidase, subunit
CG474_020375	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CG474_020385	COG2389	metal-binding protein
CG474_020395	COG1368	sulfuric ester hydrolase activity
CG474_020405	COG1388	LysM domain
CG474_020405	COG0791	NLP P60 protein
CG474_020410	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG474_020420	COG1215	transferase activity, transferring glycosyl groups
CG474_020430	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CG474_020435	COG3584	3D domain protein
CG474_020435	COG1388	LysM domain
CG474_020450	COG4715	Zinc finger, swim domain protein
CG474_020495	COG0577	efflux transmembrane transporter activity
CG474_020500	COG1136	(ABC) transporter
CG474_020535	COG5002	protein histidine kinase activity
CG474_020535	COG3850	Histidine kinase
CG474_020540	COG0745	RESPONSE REGULATOR receiver
CG474_020545	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CG474_020555	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CG474_020560	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CG474_020565	COG1134	teichoic acid transport
CG474_020570	COG1682	transport, permease protein
CG474_020575	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CG474_020585	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CG474_020590	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CG474_020595	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CG474_020605	COG1609	Transcriptional regulator
CG474_020615	COG0739	heme binding
CG474_020630	COG3279	Response regulator of the LytR AlgR family
CG474_020635	COG2385	sporulation resulting in formation of a cellular spore
CG474_020650	COG4836	Membrane
CG474_020655	COG1007	ATP synthesis coupled electron transport
CG474_020660	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG474_020670	COG0713	ATP synthesis coupled electron transport
CG474_020675	COG0839	Belongs to the complex I subunit 6 family
CG474_020685	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CG474_020690	COG0649	NAD binding
CG474_020695	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG474_020700	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG474_020705	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG474_020710	COG5001	Diguanylate cyclase
CG474_020710	COG3300	MHYT domain
CG474_020715	COG5001	Diguanylate cyclase
CG474_020715	COG3300	MHYT domain
CG474_020730	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CG474_020735	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CG474_020740	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CG474_020745	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CG474_020750	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CG474_020755	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CG474_020760	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CG474_020785	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CG474_020790	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CG474_020800	COG0698	ribose 5-phosphate isomerase
CG474_020820	COG2190	(PTS) system
CG474_020825	COG2259	Doxx family
CG474_020830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CG474_020845	COG0009	L-threonylcarbamoyladenylate synthase
CG474_020860	COG2890	protein-(glutamine-N5) methyltransferase activity
CG474_020865	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CG474_020870	COG1435	thymidine kinase activity
CG474_020880	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CG474_020885	COG1494	fructose-1,6-bisphosphatase
CG474_020905	COG4821	SIS domain
CG474_020910	COG0504	CTP synthase activity
CG474_020925	COG1960	acyl-CoA dehydrogenase activity
CG474_020930	COG1960	acyl-CoA dehydrogenase activity
CG474_020935	COG1250	3-hydroxyacyl-CoA dehydrogenase
CG474_020940	COG0183	Belongs to the thiolase family
CG474_020945	COG0247	lactate metabolic process
CG474_020945	COG2181	nitrate reductase activity
CG474_020950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CG474_020965	COG2197	response regulator
CG474_020970	COG4585	Histidine kinase
CG474_020975	COG0842	Transport permease protein
CG474_020980	COG1131	(ABC) transporter
CG474_020985	COG0024	Methionine aminopeptidase
CG474_020990	COG2234	aminopeptidase activity
CG474_021005	COG4506	Protein conserved in bacteria
CG474_021010	COG1619	proteins homologs of microcin C7 resistance protein MccF
CG474_021030	COG0010	Belongs to the arginase family
CG474_021035	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CG474_021040	COG2814	Major facilitator Superfamily
CG474_021045	COG0789	Transcriptional regulator
CG474_021050	COG0584	glycerophosphoryl diester phosphodiesterase
CG474_021055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG474_021060	COG2801	Transposase and inactivated derivatives
CG474_021065	COG1404	Belongs to the peptidase S8 family
CG474_021085	COG1994	Peptidase M50
CG474_021095	COG1078	dGTPase activity
CG474_021100	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG474_021105	COG1120	ATPase activity
CG474_021110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG474_021115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG474_021120	COG4844	belongs to the
CG474_021135	COG0280	phosphate acetyltransferase
CG474_021150	COG3773	Cell wall hydrolase
CG474_021160	COG2363	Small membrane protein
CG474_021170	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CG474_021175	COG2233	PERMEase
CG474_021180	COG0561	phosphatase activity
CG474_021185	COG2814	Major facilitator Superfamily
CG474_021190	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CG474_021195	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CG474_021200	COG1131	(ABC) transporter
CG474_021205	COG2755	lipolytic protein G-D-S-L family
CG474_021210	COG0460	homoserine dehydrogenase
CG474_021215	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CG474_021230	COG0351	phosphomethylpyrimidine kinase
CG474_021240	COG1966	Carbon starvation protein
CG474_021245	COG3279	Response regulator of the LytR AlgR family
CG474_021255	COG0477	Major facilitator Superfamily
CG474_021265	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CG474_021270	COG0438	transferase activity, transferring glycosyl groups
CG474_021285	COG0840	transmembrane signaling receptor activity
CG474_021310	COG1607	acyl-coa hydrolase
CG474_021315	COG1216	Glycosyl transferase, family 2
CG474_021330	COG0463	Glycosyl transferase, family 2
CG474_021345	COG0463	Glycosyl transferase, family 2
CG474_021350	COG0488	(ABC) transporter
CG474_021355	COG1309	transcriptional regulator
CG474_021360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CG474_021365	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CG474_021365	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CG474_021370	COG0628	permease
CG474_021375	COG1346	cytolysis
CG474_021385	COG3279	Response regulator of the LytR AlgR family
CG474_021390	COG3275	phosphorelay sensor kinase activity
CG474_021395	COG2814	Major facilitator Superfamily
CG474_021400	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
CG474_021405	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CG474_021415	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CG474_021420	COG3711	transcriptional antiterminator
CG474_021420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG474_021510	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CG474_021520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CG474_021525	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CG474_021530	COG4853	Protein conserved in bacteria
CG474_021540	COG5002	protein histidine kinase activity
CG474_021545	COG0745	RESPONSE REGULATOR receiver
CG474_021570	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CG474_021575	COG0305	Participates in initiation and elongation during chromosome replication
CG474_021580	COG0359	binds to the 23S rRNA
CG474_021585	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CG474_021590	COG4241	membrane
CG474_021595	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CG474_021600	COG0629	single-stranded DNA binding
CG474_021605	COG0360	Binds together with S18 to 16S ribosomal RNA
CG474_021610	COG0012	GTP binding
CG474_021615	COG4481	Protein conserved in bacteria
CG474_021620	COG0668	transmembrane transport
CG474_021635	COG1192	Involved in chromosome partitioning
CG474_021640	COG1475	DNA binding
CG474_021645	COG0357	Ribosomal RNA small subunit methyltransferase G
CG474_021650	COG0445	tRNA wobble uridine modification
CG474_021655	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CG474_021660	COG1847	R3H domain protein
CG474_021665	COG0706	membrane insertase activity
CG474_021670	COG0594	ribonuclease P activity
CG474_021800	COG1476	TRANSCRIPTIONal
CG474_021805	COG2197	response regulator
CG474_021815	COG1073	alpha beta
CG474_021850	COG0457	Tetratricopeptide repeat
CG474_021885	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CG474_021890	COG3209	COG3209 Rhs family protein
CG474_021905	COG2003	Belongs to the UPF0758 family
CG474_022075	COG0791	NLP P60 protein
CG474_022075	COG0741	lytic transglycosylase activity
CG474_022120	COG0583	DNA-binding transcription factor activity
CG474_022140	COG1028	Short-chain dehydrogenase reductase Sdr
CG474_022235	COG1192	Involved in chromosome partitioning
CG474_022275	COG0457	Tetratricopeptide repeat
CG474_022285	COG4166	transmembrane transport
CG474_022320	COG4974	Belongs to the 'phage' integrase family