locus-tag	class	description
CG479_000005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CG479_000010	COG0592	DNA-directed DNA polymerase activity
CG479_000015	COG2501	S4 domain
CG479_000020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CG479_000025	COG0187	DNA topoisomerase II activity
CG479_000030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CG479_000065	COG0517	IMP dehydrogenase activity
CG479_000065	COG0516	GMP reductase activity
CG479_000070	COG1686	Belongs to the peptidase S11 family
CG479_000075	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CG479_000080	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CG479_000085	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CG479_000100	COG1428	Deoxynucleoside kinase
CG479_000105	COG1428	Deoxynucleoside kinase
CG479_000110	COG1335	isochorismatase
CG479_000115	COG0590	tRNA wobble adenosine to inosine editing
CG479_000125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CG479_000130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CG479_000135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CG479_000180	COG1982	Orn Lys Arg decarboxylase major
CG479_000185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CG479_000190	COG0470	DNA polymerase III
CG479_000195	COG1774	PSP1 C-terminal conserved region
CG479_000200	COG4467	Involved in initiation control of chromosome replication
CG479_000205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CG479_000215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CG479_000220	COG2002	toxin-antitoxin pair type II binding
CG479_000230	COG0084	hydrolase, TatD family'
CG479_000240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CG479_000250	COG4466	Protein conserved in bacteria
CG479_000260	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CG479_000265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CG479_000270	COG0251	oxidation-reduction process
CG479_000275	COG2088	sporulation resulting in formation of a cellular spore
CG479_000280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CG479_000285	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CG479_000290	COG0193	aminoacyl-tRNA hydrolase activity
CG479_000300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CG479_000305	COG2002	toxin-antitoxin pair type II binding
CG479_000310	COG2244	polysaccharide biosynthetic process
CG479_000315	COG3956	TIGRFAM MazG family protein
CG479_000320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CG479_000340	COG1098	S1 RNA binding domain
CG479_000370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CG479_000375	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CG479_000380	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CG479_000385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CG479_000390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CG479_000395	COG0512	Glutamine amidotransferase of anthranilate synthase
CG479_000400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CG479_000405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CG479_000410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CG479_000415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CG479_000420	COG1396	sequence-specific DNA binding
CG479_000425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CG479_000430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CG479_000465	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG479_000515	COG3880	PFAM UvrB UvrC protein
CG479_000520	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CG479_000525	COG0542	response to heat
CG479_000530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CG479_000540	COG4956	integral membrane protein (PIN domain superfamily)
CG479_000545	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CG479_000550	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CG479_000555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CG479_000560	COG1045	serine acetyltransferase
CG479_000565	COG0215	cysteine-tRNA ligase activity
CG479_000575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CG479_000580	COG3688	RNA-binding protein containing a PIN domain
CG479_000600	COG0250	Participates in transcription elongation, termination and antitermination
CG479_000610	COG0081	regulation of translation
CG479_000615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CG479_000620	COG0222	ribosome binding
CG479_000625	COG2813	Specifically methylates the guanine in position
CG479_000635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CG479_000640	COG1358	cellular component organization or biogenesis
CG479_000645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CG479_000650	COG0049	tRNA binding
CG479_000655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CG479_000660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CG479_000670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CG479_000675	COG0088	Forms part of the polypeptide exit tunnel
CG479_000680	COG0089	rRNA binding
CG479_000685	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CG479_000690	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CG479_000695	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CG479_000700	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CG479_000705	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CG479_000715	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CG479_000720	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CG479_000725	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CG479_000730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CG479_000740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CG479_000745	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CG479_000750	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CG479_000755	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CG479_000760	COG1841	ribosomal large subunit assembly
CG479_000765	COG0200	Binds to the 23S rRNA
CG479_000770	COG0201	protein transport
CG479_000775	COG0563	adenylate kinase activity
CG479_000780	COG0024	Methionine aminopeptidase
CG479_000790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CG479_000800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CG479_000805	COG0202	RNA polymerase activity
CG479_000820	COG1122	ATPase activity
CG479_000825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CG479_000835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CG479_000840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CG479_000850	COG0860	N-Acetylmuramoyl-L-alanine amidase
CG479_000855	COG0489	protein tyrosine kinase activity
CG479_000865	COG2194	sulfuric ester hydrolase activity
CG479_000870	COG0726	polysaccharide deacetylase
CG479_000950	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CG479_000960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CG479_000980	COG1619	proteins homologs of microcin C7 resistance protein MccF
CG479_000990	COG0489	protein tyrosine kinase activity
CG479_000995	COG0019	diaminopimelate decarboxylase activity
CG479_001015	COG1266	CAAX protease self-immunity
CG479_001095	COG3681	Belongs to the UPF0597 family
CG479_001100	COG3681	Belongs to the UPF0597 family
CG479_001125	COG2814	Major facilitator Superfamily
CG479_001135	COG0601	transmembrane transport
CG479_001140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CG479_001145	COG0444	Belongs to the ABC transporter superfamily
CG479_001150	COG4608	Belongs to the ABC transporter superfamily
CG479_001155	COG4166	transmembrane transport
CG479_001175	COG1309	transcriptional regulator
CG479_001185	COG0656	L-ascorbic acid biosynthetic process
CG479_001190	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CG479_001200	COG4149	molybdate abc transporter
CG479_001205	COG0725	ABC transporter, periplasmic molybdate-binding protein
CG479_001210	COG1910	domain protein
CG479_001215	COG0204	Acyl-transferase
CG479_001220	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG479_001225	COG1648	precorrin-2 dehydrogenase activity
CG479_001225	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CG479_001235	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CG479_001235	COG1587	Uroporphyrinogen-III synthase
CG479_001240	COG2146	nitrite reductase [NAD(P)H] activity
CG479_001245	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CG479_001275	COG4585	Histidine kinase
CG479_001280	COG2197	response regulator
CG479_001285	COG1131	(ABC) transporter
CG479_001290	COG1511	domain protein
CG479_001290	COG0842	Transport permease protein
CG479_001295	COG0842	Transport permease protein
CG479_001305	COG0747	negative chemotaxis
CG479_001310	COG0601	transmembrane transport
CG479_001315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CG479_001320	COG0444	Belongs to the ABC transporter superfamily
CG479_001325	COG4608	Belongs to the ABC transporter superfamily
CG479_001330	COG0561	phosphatase activity
CG479_001350	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CG479_001355	COG0179	Fumarylacetoacetate (FAA) hydrolase
CG479_001365	COG2814	Major facilitator Superfamily
CG479_001370	COG1181	Belongs to the D-alanine--D-alanine ligase family
CG479_001375	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CG479_001385	COG0457	Tetratricopeptide repeat
CG479_001385	COG0705	Rhomboid family
CG479_001390	COG0736	holo-[acyl-carrier-protein] synthase activity
CG479_001395	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CG479_001405	COG0864	Transcriptional regulator
CG479_001410	COG2337	Toxic component of a toxin-antitoxin (TA) module
CG479_001415	COG2183	response to ionizing radiation
CG479_001425	COG3091	SprT-like family
CG479_001465	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG479_001515	COG0802	atpase or kinase
CG479_001520	COG1214	PFAM Peptidase M22, glycoprotease
CG479_001525	COG0456	acetyltransferase
CG479_001535	COG0488	(ABC) transporter
CG479_001540	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CG479_001550	COG1266	CAAX protease self-immunity
CG479_001555	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CG479_001560	COG0459	protein refolding
CG479_001565	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CG479_001565	COG0519	Catalyzes the synthesis of GMP from XMP
CG479_001570	COG2252	PERMEase
CG479_001580	COG5002	protein histidine kinase activity
CG479_001650	COG2205	protein histidine kinase activity
CG479_001655	COG0745	RESPONSE REGULATOR receiver
CG479_001675	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CG479_001680	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CG479_001685	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CG479_001690	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CG479_001695	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CG479_001700	COG0047	phosphoribosylformylglycinamidine synthase activity
CG479_001705	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CG479_001710	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CG479_001715	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CG479_001720	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CG479_001725	COG0138	bifunctional purine biosynthesis protein purh
CG479_001730	COG0151	Belongs to the GarS family
CG479_001740	COG0583	DNA-binding transcription factor activity
CG479_001760	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CG479_001765	COG0210	DNA helicase
CG479_001770	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CG479_001775	COG4851	CamS sex pheromone cAM373 precursor
CG479_001785	COG1012	belongs to the aldehyde dehydrogenase family
CG479_001790	COG1335	isochorismatase
CG479_001800	COG2011	ABC-type metal ion transport system permease component
CG479_001820	COG4682	membrane
CG479_001825	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CG479_001830	COG0154	amidase activity
CG479_001835	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CG479_001840	COG1597	lipid kinase activity
CG479_001845	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CG479_001850	COG0546	phosphoglycolate phosphatase activity
CG479_001855	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CG479_001865	COG0531	amino acid
CG479_001870	COG1012	belongs to the aldehyde dehydrogenase family
CG479_001875	COG2076	Multidrug Resistance protein
CG479_001880	COG2309	aminopeptidase activity
CG479_001890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG479_001895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CG479_001900	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CG479_001915	COG0450	alkyl hydroperoxide reductase
CG479_001940	COG0714	Associated with various cellular activities
CG479_001975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG479_001980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG479_001985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG479_001990	COG0492	ferredoxin-NADP+ reductase activity
CG479_002000	COG0166	Belongs to the GPI family
CG479_002030	COG3541	Predicted nucleotidyltransferase
CG479_002035	COG2814	Major facilitator Superfamily
CG479_002040	COG0723	plastoquinol--plastocyanin reductase activity
CG479_002040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CG479_002050	COG0765	amino acid transport
CG479_002055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG479_002060	COG1126	abc transporter atp-binding protein
CG479_002065	COG0840	transmembrane signaling receptor activity
CG479_002075	COG2235	arginine
CG479_002090	COG0549	Belongs to the carbamate kinase family
CG479_002105	COG0366	Alpha amylase catalytic
CG479_002110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG479_002110	COG2190	(PTS) system
CG479_002110	COG1263	PTS System
CG479_002130	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG479_002135	COG4605	iron ion homeostasis
CG479_002140	COG4604	ABC transporter, ATP-binding protein
CG479_002145	COG4607	ABC-type enterochelin transport system periplasmic component
CG479_002150	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CG479_002155	COG0352	thiamine-phosphate diphosphorylase activity
CG479_002160	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CG479_002180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG479_002190	COG1116	anion transmembrane transporter activity
CG479_002225	COG2270	Major facilitator Superfamily
CG479_002250	COG2310	stress, protein
CG479_002255	COG2310	stress, protein
CG479_002260	COG2310	stress, protein
CG479_002265	COG0861	Integral membrane protein TerC family
CG479_002275	COG3853	Toxic anion resistance protein (TelA)
CG479_002285	COG4840	Belongs to the UPF0435 family
CG479_002290	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CG479_002300	COG1295	ribonuclease BN
CG479_002305	COG2217	Heavy metal translocating P-type atpase
CG479_002310	COG0697	spore germination
CG479_002320	COG0681	Belongs to the peptidase S26 family
CG479_002330	COG0586	Pfam SNARE associated Golgi protein
CG479_002345	COG0387	Pfam Sodium calcium exchanger
CG479_002355	COG0535	radical SAM domain protein
CG479_002375	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CG479_002400	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CG479_002455	COG2066	Belongs to the glutaminase family
CG479_002460	COG1263	PTS System
CG479_002460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG479_002465	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG479_002475	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CG479_002475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CG479_002485	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CG479_002490	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CG479_002505	COG0402	S-adenosylhomocysteine deaminase activity
CG479_002510	COG2137	regulation of response to DNA damage stimulus
CG479_002535	COG1988	membrane-bound metal-dependent
CG479_002540	COG1194	a g-specific adenine glycosylase
CG479_002565	COG3557	Belongs to the UPF0374 family
CG479_002570	COG1132	(ABC) transporter
CG479_002575	COG4129	membrane
CG479_002580	COG0070	glutamate synthase
CG479_002580	COG0067	glutamate synthase
CG479_002580	COG0069	glutamate synthase activity
CG479_002585	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CG479_002590	COG4555	ABC transporter
CG479_002610	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CG479_002615	COG0735	belongs to the Fur family
CG479_002735	COG0457	Tetratricopeptide repeat
CG479_002740	COG0217	transcriptional regulatory protein
CG479_002745	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CG479_002750	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CG479_002770	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CG479_002780	COG2766	serine protein kinase
CG479_002805	COG1280	lysine exporter protein (LysE YggA)
CG479_002845	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CG479_002855	COG1585	Membrane protein implicated in regulation of membrane protease activity
CG479_002860	COG2268	Band 7 protein
CG479_002890	COG4990	cell redox homeostasis
CG479_002900	COG3290	protein histidine kinase activity
CG479_002905	COG4565	transcriptional regulatory protein
CG479_002910	COG3493	citrate carrier protein
CG479_002915	COG0281	malic enzyme
CG479_002930	COG5002	protein histidine kinase activity
CG479_002935	COG0745	RESPONSE REGULATOR receiver
CG479_002945	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CG479_002950	COG3383	formate dehydrogenase (NAD+) activity
CG479_002955	COG2427	Protein of unknown function (DUF1641)
CG479_002965	COG0840	transmembrane signaling receptor activity
CG479_002975	COG0531	amino acid
CG479_002990	COG0640	Transcriptional regulator
CG479_002995	COG2217	Heavy metal translocating P-type atpase
CG479_003000	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CG479_003010	COG3227	Zinc metalloprotease (Elastase)
CG479_003025	COG2217	Heavy metal translocating P-type atpase
CG479_003045	COG2720	vancomycin resistance protein
CG479_003050	COG1316	TRANSCRIPTIONal
CG479_003060	COG1253	flavin adenine dinucleotide binding
CG479_003065	COG1027	Aspartate ammonia-lyase
CG479_003070	COG1620	l-lactate permease
CG479_003090	COG3104	oligopeptide transport
CG479_003095	COG0156	8-amino-7-oxononanoate synthase activity
CG479_003100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CG479_003105	COG4548	von Willebrand factor, type A
CG479_003110	COG0714	Associated with various cellular activities
CG479_003115	COG0531	amino acid
CG479_003125	COG1115	amino acid carrier protein
CG479_003135	COG1126	abc transporter atp-binding protein
CG479_003140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG479_003145	COG0765	amino acid transport
CG479_003150	COG0765	amino acid transport
CG479_003155	COG0833	amino acid
CG479_003165	COG5002	protein histidine kinase activity
CG479_003170	COG0745	RESPONSE REGULATOR receiver
CG479_003180	COG0659	secondary active sulfate transmembrane transporter activity
CG479_003185	COG0589	response to stress
CG479_003195	COG0747	negative chemotaxis
CG479_003205	COG0601	transmembrane transport
CG479_003210	COG4608	Belongs to the ABC transporter superfamily
CG479_003220	COG2271	Major facilitator Superfamily
CG479_003225	COG1846	Transcriptional regulator
CG479_003230	COG0477	Major facilitator Superfamily
CG479_003235	COG1609	Transcriptional regulator
CG479_003240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CG479_003245	COG1869	D-ribose catabolic process
CG479_003250	COG1129	ABC transporter
CG479_003255	COG1172	Belongs to the binding-protein-dependent transport system permease family
CG479_003260	COG1879	ABC-type sugar transport system periplasmic component
CG479_003265	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CG479_003280	COG3568	Endonuclease Exonuclease Phosphatase
CG479_003305	COG0840	transmembrane signaling receptor activity
CG479_003310	COG3583	domain protein
CG479_003310	COG3584	3D domain protein
CG479_003315	COG1476	TRANSCRIPTIONal
CG479_003345	COG1114	Component of the transport system for branched-chain amino acids
CG479_003355	COG1113	amino acid transport
CG479_003360	COG2153	protein acetylation
CG479_003370	COG0475	glutathione-regulated potassium exporter activity
CG479_003370	COG0569	domain protein
CG479_003385	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CG479_003390	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CG479_003395	COG0833	amino acid
CG479_003400	COG4990	cell redox homeostasis
CG479_003415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG479_003420	COG0697	spore germination
CG479_003425	COG0531	amino acid
CG479_003440	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CG479_003445	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CG479_003450	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CG479_003450	COG1918	ferrous iron import across plasma membrane
CG479_003455	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CG479_003460	COG0573	inorganic phosphate transmembrane transporter activity
CG479_003465	COG0581	inorganic phosphate transmembrane transporter activity
CG479_003470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CG479_003510	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG479_003585	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CG479_003610	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CG479_003615	COG1116	anion transmembrane transporter activity
CG479_003620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG479_003625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CG479_003630	COG0352	thiamine-phosphate diphosphorylase activity
CG479_003635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CG479_003640	COG2104	thiamine diphosphate biosynthetic process
CG479_003645	COG2022	thiamine diphosphate biosynthetic process
CG479_003650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG479_003655	COG0351	phosphomethylpyrimidine kinase
CG479_003685	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CG479_003690	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CG479_003695	COG2205	protein histidine kinase activity
CG479_003700	COG2814	Major facilitator Superfamily
CG479_003705	COG1846	Transcriptional regulator
CG479_003715	COG2252	PERMEase
CG479_003720	COG1028	Short-chain dehydrogenase reductase Sdr
CG479_003725	COG1376	ErfK ybiS ycfS ynhG family protein
CG479_003750	COG1316	TRANSCRIPTIONal
CG479_003780	COG0778	Nitroreductase
CG479_003790	COG2719	SpoVR family
CG479_003800	COG1316	TRANSCRIPTIONal
CG479_003805	COG1283	sodium-dependent phosphate transmembrane transporter activity
CG479_003820	COG0577	efflux transmembrane transporter activity
CG479_003825	COG1136	(ABC) transporter
CG479_003835	COG1114	Component of the transport system for branched-chain amino acids
CG479_003840	COG3546	catalase activity
CG479_003895	COG0475	glutathione-regulated potassium exporter activity
CG479_003900	COG1737	Transcriptional regulator
CG479_003910	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CG479_003915	COG1263	PTS System
CG479_003915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG479_003965	COG1522	sequence-specific DNA binding
CG479_003980	COG0531	amino acid
CG479_003990	COG1012	belongs to the aldehyde dehydrogenase family
CG479_003995	COG1132	(ABC) transporter
CG479_004000	COG1132	(ABC) transporter
CG479_004010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG479_004015	COG0765	amino acid transport
CG479_004020	COG1126	abc transporter atp-binding protein
CG479_004035	COG0189	ligase activity
CG479_004040	COG4399	Belongs to the UPF0754 family
CG479_004045	COG3679	Belongs to the UPF0342 family
CG479_004050	COG4585	Histidine kinase
CG479_004055	COG2197	response regulator
CG479_004090	COG2094	Belongs to the DNA glycosylase MPG family
CG479_004095	COG0561	phosphatase activity
CG479_004105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CG479_004135	COG2244	polysaccharide biosynthetic process
CG479_004145	COG0860	N-Acetylmuramoyl-L-alanine amidase
CG479_004165	COG1696	Membrane protein involved in D-alanine export
CG479_004180	COG1024	Enoyl-CoA hydratase
CG479_004195	COG1363	Peptidase, m42
CG479_004210	COG2239	Acts as a magnesium transporter
CG479_004215	COG0772	Belongs to the SEDS family
CG479_004220	COG1115	amino acid carrier protein
CG479_004330	COG0457	Tetratricopeptide repeat
CG479_004400	COG1061	Type III restriction enzyme res subunit
CG479_004415	COG4638	Rieske (2fe-2S)
CG479_004420	COG1012	belongs to the aldehyde dehydrogenase family
CG479_004425	COG0473	3-isopropylmalate dehydrogenase activity
CG479_004435	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG479_004445	COG1064	alcohol dehydrogenase
CG479_004460	COG3246	L-lysine catabolic process to acetate
CG479_004495	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CG479_004505	COG4641	Protein conserved in bacteria
CG479_004520	COG3711	transcriptional antiterminator
CG479_004525	COG2190	(PTS) system
CG479_004525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG479_004525	COG1263	PTS System
CG479_004530	COG2723	6-phospho-beta-galactosidase activity
CG479_004540	COG2376	Dihydroxyacetone kinase
CG479_004545	COG0393	Putative heavy-metal-binding
CG479_004575	COG0420	3'-5' exonuclease activity
CG479_004580	COG4717	serine-type aminopeptidase activity
CG479_004585	COG3481	metal-dependent phosphohydrolase, HD sub domain
CG479_004600	COG0577	efflux transmembrane transporter activity
CG479_004605	COG1136	(ABC) transporter
CG479_004615	COG5002	protein histidine kinase activity
CG479_004620	COG0745	RESPONSE REGULATOR receiver
CG479_004630	COG1316	TRANSCRIPTIONal
CG479_004645	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CG479_004650	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CG479_004655	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CG479_004660	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CG479_004680	COG1846	Transcriptional regulator
CG479_004685	COG4980	gas vesicle protein
CG479_004695	COG0537	adenosine 5'-monophosphoramidase activity
CG479_004700	COG1131	(ABC) transporter
CG479_004705	COG4473	ABC transporter
CG479_004725	COG3402	PFAM membrane-flanked domain
CG479_004735	COG2329	Antibiotic biosynthesis monooxygenase
CG479_004740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG479_004745	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CG479_004785	COG1309	transcriptional regulator
CG479_004795	COG0438	transferase activity, transferring glycosyl groups
CG479_004795	COG1216	Glycosyl transferase, family 2
CG479_004805	COG1609	Transcriptional regulator
CG479_004815	COG1234	tRNA 3'-trailer cleavage
CG479_004820	COG0095	Lipoate-protein ligase
CG479_004830	COG0318	PFAM AMP-dependent synthetase and ligase
CG479_004845	COG2205	protein histidine kinase activity
CG479_004850	COG0745	RESPONSE REGULATOR receiver
CG479_004870	COG0501	Belongs to the peptidase M48B family
CG479_004875	COG0840	transmembrane signaling receptor activity
CG479_004880	COG0697	spore germination
CG479_004895	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CG479_004900	COG2224	Isocitrate lyase
CG479_004905	COG1278	Cold shock
CG479_004910	COG4903	ComK protein
CG479_004915	COG0398	Pfam SNARE associated Golgi protein
CG479_004925	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CG479_004930	COG1074	ATP-dependent DNA helicase activity
CG479_004970	COG0179	Fumarylacetoacetate (FAA) hydrolase
CG479_004990	COG0367	asparagine synthase
CG479_005000	COG0753	catalase activity
CG479_005010	COG0366	Alpha amylase catalytic
CG479_005010	COG1874	Beta-galactosidase
CG479_005015	COG1666	GTP binding
CG479_005020	COG2996	Protein conserved in bacteria
CG479_005035	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG479_005050	COG0561	phosphatase activity
CG479_005075	COG2267	carboxylic ester hydrolase activity
CG479_005090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CG479_005095	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CG479_005100	COG5504	Zn-dependent protease
CG479_005110	COG0180	Tryptophanyl-tRNA synthetase
CG479_005135	COG0601	transmembrane transport
CG479_005140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CG479_005145	COG0444	Belongs to the ABC transporter superfamily
CG479_005150	COG4608	Belongs to the ABC transporter superfamily
CG479_005155	COG0534	Mate efflux family protein
CG479_005160	COG4166	transmembrane transport
CG479_005180	COG1393	Belongs to the ArsC family
CG479_005185	COG0861	Integral membrane protein TerC family
CG479_005205	COG1164	Oligoendopeptidase f
CG479_005220	COG2346	COG2346, Truncated hemoglobins
CG479_005225	COG4116	CYTH
CG479_005235	COG2357	RelA SpoT domain protein
CG479_005245	COG0564	pseudouridine synthase activity
CG479_005255	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CG479_005260	COG0772	Belongs to the SEDS family
CG479_005305	COG1216	Glycosyl transferase, family 2
CG479_005350	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CG479_005365	COG1091	dTDP-4-dehydrorhamnose reductase activity
CG479_005390	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CG479_005395	COG2382	esterase
CG479_005410	COG5492	domain, Protein
CG479_005415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG479_005430	COG1620	l-lactate permease
CG479_005435	COG5634	Uncharacterized conserved protein (DUF2278)
CG479_005475	COG0508	dehydrogenase complex catalyzes the overall conversion of
CG479_005480	COG0567	Dehydrogenase, E1 component
CG479_005490	COG0583	DNA-binding transcription factor activity
CG479_005495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CG479_005500	COG1012	belongs to the aldehyde dehydrogenase family
CG479_005515	COG0196	riboflavin kinase activity
CG479_005520	COG3162	membrane
CG479_005525	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG479_005530	COG0179	Fumarylacetoacetate (FAA) hydrolase
CG479_005545	COG0457	Tetratricopeptide repeat
CG479_005630	COG0457	Tetratricopeptide repeat
CG479_005635	COG0582	viral genome integration into host DNA
CG479_005670	COG1686	Belongs to the peptidase S11 family
CG479_005675	COG0681	Belongs to the peptidase S26 family
CG479_005710	COG1012	belongs to the aldehyde dehydrogenase family
CG479_005720	COG1176	ABC-type spermidine putrescine transport system, permease component I
CG479_005725	COG1177	transmembrane transport
CG479_005730	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CG479_005735	COG0671	phosphoesterase, PA-phosphatase related
CG479_005740	COG2409	Drug exporters of the RND superfamily
CG479_005750	COG0564	pseudouridine synthase activity
CG479_005760	COG2340	Cysteine-rich secretory protein family
CG479_005765	COG0247	lactate metabolic process
CG479_005770	COG0277	FAD linked oxidase domain protein
CG479_005775	COG3835	regulator
CG479_005785	COG0745	RESPONSE REGULATOR receiver
CG479_005790	COG5002	protein histidine kinase activity
CG479_005795	COG2186	Transcriptional regulator
CG479_005800	COG0247	lactate metabolic process
CG479_005805	COG1139	Iron-sulfur cluster binding protein
CG479_005810	COG1556	Lactate utilization protein
CG479_005815	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CG479_005820	COG0584	glycerophosphoryl diester phosphodiesterase
CG479_005830	COG2267	carboxylic ester hydrolase activity
CG479_005835	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG479_005855	COG2116	formate transmembrane transporter activity
CG479_005860	COG0861	Integral membrane protein TerC family
CG479_005865	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CG479_005875	COG2030	dehydratase
CG479_005895	COG1028	Short-chain dehydrogenase reductase Sdr
CG479_005900	COG3243	poly(R)-hydroxyalkanoic acid synthase
CG479_005905	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CG479_005920	COG1840	ABC-type Fe3 transport system, periplasmic component
CG479_005925	COG3842	ATPase activity
CG479_005935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CG479_005940	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CG479_005945	COG1349	DNA-binding transcription factor activity
CG479_005950	COG0235	Class ii aldolase
CG479_005960	COG2861	carbohydrate metabolic process
CG479_005975	COG3852	Histidine kinase
CG479_005980	COG1846	Transcriptional regulator
CG479_006000	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CG479_006005	COG0720	synthase
CG479_006015	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CG479_006020	COG4873	Protein conserved in bacteria
CG479_006030	COG0456	acetyltransferase
CG479_006050	COG1780	Probably involved in ribonucleotide reductase function
CG479_006065	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CG479_006070	COG1725	Transcriptional regulator
CG479_006075	COG1131	(ABC) transporter
CG479_006085	COG1131	(ABC) transporter
CG479_006090	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CG479_006105	COG1522	sequence-specific DNA binding
CG479_006120	COG1619	proteins homologs of microcin C7 resistance protein MccF
CG479_006125	COG2070	2-Nitropropane dioxygenase
CG479_006130	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CG479_006140	COG1696	Membrane protein involved in D-alanine export
CG479_006145	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CG479_006160	COG0716	FMN binding
CG479_006185	COG1368	sulfuric ester hydrolase activity
CG479_006195	COG3173	Aminoglycoside phosphotransferase
CG479_006210	COG5609	conserved protein (DUF2294)
CG479_006215	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CG479_006220	COG3002	Belongs to the UPF0753 family
CG479_006225	COG0288	reversible hydration of carbon dioxide
CG479_006230	COG0534	Mate efflux family protein
CG479_006245	COG1846	Transcriptional regulator
CG479_006255	COG1301	dicarboxylic acid transport
CG479_006260	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CG479_006270	COG3874	Sporulation protein YtfJ
CG479_006290	COG0028	Belongs to the TPP enzyme family
CG479_006295	COG0440	acetolactate synthase activity
CG479_006300	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CG479_006305	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CG479_006315	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CG479_006320	COG0066	3-isopropylmalate dehydratase activity
CG479_006330	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CG479_006340	COG0131	Imidazoleglycerol-phosphate dehydratase
CG479_006345	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CG479_006350	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CG479_006355	COG0107	imidazoleglycerol-phosphate synthase activity
CG479_006360	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CG479_006365	COG0140	phosphoribosyl-ATP diphosphatase activity
CG479_006380	COG1183	phosphatidylcholine synthase activity
CG479_006385	COG1368	sulfuric ester hydrolase activity
CG479_006395	COG0019	diaminopimelate decarboxylase activity
CG479_006405	COG0175	sulfate reduction
CG479_006410	COG2046	Belongs to the sulfate adenylyltransferase family
CG479_006415	COG0529	Catalyzes the synthesis of activated sulfate
CG479_006420	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CG479_006440	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CG479_006440	COG1648	precorrin-2 dehydrogenase activity
CG479_006445	COG0733	neurotransmitter:sodium symporter activity
CG479_006460	COG3557	Belongs to the UPF0374 family
CG479_006465	COG1757	Na H antiporter
CG479_006480	COG4758	membrane
CG479_006485	COG4585	Histidine kinase
CG479_006490	COG2197	response regulator
CG479_006495	COG1114	Component of the transport system for branched-chain amino acids
CG479_006500	COG1525	nuclease
CG479_006500	COG4085	toxin activity
CG479_006500	COG0737	Belongs to the 5'-nucleotidase family
CG479_006530	COG3711	transcriptional antiterminator
CG479_006530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG479_006535	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG479_006535	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG479_006535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG479_006540	COG1482	cell wall glycoprotein biosynthetic process
CG479_006550	COG2801	Transposase and inactivated derivatives
CG479_006570	COG0730	response to heat
CG479_006575	COG0306	phosphate transporter
CG479_006580	COG1392	Phosphate transport regulator
CG479_006585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG479_006595	COG3852	Histidine kinase
CG479_006600	COG1801	Protein of unknown function DUF72
CG479_006610	COG0582	viral genome integration into host DNA
CG479_006615	COG5002	protein histidine kinase activity
CG479_006620	COG0813	purine-nucleoside phosphorylase activity
CG479_006630	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CG479_006630	COG0392	lysyltransferase activity
CG479_006645	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CG479_006650	COG1686	Belongs to the peptidase S11 family
CG479_006655	COG2715	membrane protein required for spore maturation
CG479_006660	COG0700	Nucleoside recognition
CG479_006665	COG1187	pseudouridine synthase activity
CG479_006675	COG1333	cytochrome c biogenesis protein
CG479_006680	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CG479_006685	COG0745	RESPONSE REGULATOR receiver
CG479_006690	COG5002	protein histidine kinase activity
CG479_006695	COG2096	Adenosyltransferase
CG479_006710	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CG479_006715	COG1141	Ferredoxin
CG479_006725	COG0514	ATP-dependent DNA helicase (RecQ)
CG479_006730	COG1266	CAAX protease self-immunity
CG479_006740	COG1408	metallophosphoesterase
CG479_006755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CG479_006770	COG0492	ferredoxin-NADP+ reductase activity
CG479_006785	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CG479_006795	COG1304	FMN binding
CG479_006820	COG1160	GTP binding
CG479_006825	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CG479_006845	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CG479_006855	COG0302	gtp cyclohydrolase
CG479_006860	COG0142	geranyltranstransferase activity
CG479_006865	COG2226	methyltransferase
CG479_006870	COG0142	geranyltranstransferase activity
CG479_006875	COG0105	UTP biosynthetic process
CG479_006880	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CG479_006885	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CG479_006890	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CG479_006895	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CG479_006900	COG0457	Tetratricopeptide repeat
CG479_006905	COG5582	Belongs to the UPF0302 family
CG479_006920	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CG479_006930	COG4347	Protein of unknown function (DUF1405)
CG479_006945	COG2738	Putative neutral zinc metallopeptidase
CG479_006955	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG479_006960	COG1694	Mazg nucleotide pyrophosphohydrolase
CG479_006965	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CG479_006970	COG1803	Methylglyoxal synthase
CG479_006975	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CG479_006980	COG0438	transferase activity, transferring glycosyl groups
CG479_006985	COG0617	tRNA 3'-terminal CCA addition
CG479_007000	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CG479_007005	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CG479_007010	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CG479_007015	COG1199	ATP-dependent helicase activity
CG479_007015	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CG479_007035	COG3935	DnaD domain protein
CG479_007040	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CG479_007050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG479_007050	COG4499	WXG100 protein secretion system (Wss), protein YukC
CG479_007055	COG3331	DNA recombination
CG479_007090	COG4474	Belongs to the UPF0398 family
CG479_007095	COG3599	regulation of cell shape
CG479_007105	COG0116	Belongs to the methyltransferase superfamily
CG479_007110	COG4974	Belongs to the 'phage' integrase family
CG479_007195	COG1199	ATP-dependent helicase activity
CG479_007200	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CG479_007205	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CG479_007210	COG2233	PERMEase
CG479_007215	COG2311	Membrane
CG479_007220	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CG479_007230	COG0456	acetyltransferase
CG479_007270	COG3766	membrane
CG479_007275	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CG479_007280	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CG479_007285	COG1733	regulation of RNA biosynthetic process
CG479_007305	COG0328	RNA-DNA hybrid ribonuclease activity
CG479_007335	COG1278	Cold shock
CG479_007345	COG3162	membrane
CG479_007350	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG479_007355	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CG479_007360	COG0475	glutathione-regulated potassium exporter activity
CG479_007365	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CG479_007370	COG2323	membrane
CG479_007375	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CG479_007400	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CG479_007410	COG2201	protein-glutamate methylesterase activity
CG479_007415	COG2198	Histidine kinase
CG479_007415	COG0643	Histidine kinase
CG479_007420	COG1776	CheC inhibitor of MCP methylation
CG479_007420	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG479_007435	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CG479_007445	COG1728	Protein conserved in bacteria
CG479_007455	COG1256	bacterial-type flagellum assembly
CG479_007460	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CG479_007480	COG1815	bacterial-type flagellum-dependent cell motility
CG479_007485	COG1558	bacterial-type flagellum-dependent cell motility
CG479_007490	COG1677	Flagellar hook-basal body complex protein FliE
CG479_007500	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG479_007510	COG1157	protein secretion by the type III secretion system
CG479_007545	COG0784	Response regulator, receiver
CG479_007545	COG0835	chemotaxis
CG479_007555	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CG479_007560	COG0463	Glycosyl transferase, family 2
CG479_007560	COG0457	Tetratricopeptide repeat
CG479_007575	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CG479_007580	COG0741	lytic transglycosylase activity
CG479_007590	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG479_007595	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG479_007595	COG1776	CheC inhibitor of MCP methylation
CG479_007605	COG1338	Plays a role in the flagellum-specific transport system
CG479_007610	COG1987	bacterial-type flagellum assembly
CG479_007620	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CG479_007625	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CG479_007630	COG1419	protein localization to endoplasmic reticulum
CG479_007635	COG4786	Flagellar basal body rod
CG479_007640	COG1136	(ABC) transporter
CG479_007640	COG0577	efflux transmembrane transporter activity
CG479_007670	COG1309	transcriptional regulator
CG479_007690	COG2814	Major facilitator Superfamily
CG479_007700	COG1028	Short-chain dehydrogenase reductase Sdr
CG479_007735	COG0367	asparagine synthase
CG479_007755	COG1802	Transcriptional regulator
CG479_007760	COG0697	spore germination
CG479_007770	COG1757	Na H antiporter
CG479_007775	COG0114	fumarate hydratase activity
CG479_007800	COG0534	Mate efflux family protein
CG479_007805	COG3340	Belongs to the peptidase S51 family
CG479_007810	COG2733	membrane
CG479_007820	COG1280	lysine exporter protein (LysE YggA)
CG479_007825	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CG479_007840	COG2502	aspartate--ammonia ligase
CG479_007845	COG1309	transcriptional regulator
CG479_007850	COG0109	protoheme IX farnesyltransferase activity
CG479_007880	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CG479_007890	COG4166	transmembrane transport
CG479_007895	COG2223	nitrite transmembrane transporter activity
CG479_007900	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CG479_007905	COG2244	polysaccharide biosynthetic process
CG479_007910	COG0733	neurotransmitter:sodium symporter activity
CG479_007915	COG5566	PFAM Mor transcription activator
CG479_007925	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CG479_007930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CG479_007940	COG0129	dihydroxy-acid dehydratase activity
CG479_007945	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CG479_007975	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG479_007980	COG2814	Major facilitator Superfamily
CG479_007985	COG3384	dioxygenase
CG479_008005	COG0402	S-adenosylhomocysteine deaminase activity
CG479_008010	COG4166	transmembrane transport
CG479_008020	COG1914	H( )-stimulated, divalent metal cation uptake system
CG479_008035	COG0083	homoserine kinase activity
CG479_008045	COG2390	Transcriptional regulator
CG479_008050	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CG479_008075	COG1510	regulation of RNA biosynthetic process
CG479_008085	COG1454	alcohol dehydrogenase
CG479_008115	COG0628	permease
CG479_008120	COG0039	L-malate dehydrogenase activity
CG479_008125	COG0523	cobalamin synthesis protein
CG479_008150	COG1686	Belongs to the peptidase S11 family
CG479_008165	COG1388	LysM domain
CG479_008165	COG0791	NLP P60 protein
CG479_008170	COG0300	oxidoreductase activity
CG479_008180	COG0460	homoserine dehydrogenase
CG479_008190	COG0083	homoserine kinase activity
CG479_008195	COG1316	TRANSCRIPTIONal
CG479_008200	COG0726	polysaccharide deacetylase
CG479_008210	COG1285	pathogenesis
CG479_008215	COG1247	-acetyltransferase
CG479_008250	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CG479_008255	COG0577	efflux transmembrane transporter activity
CG479_008260	COG2409	Drug exporters of the RND superfamily
CG479_008265	COG1404	Belongs to the peptidase S8 family
CG479_008280	COG0840	transmembrane signaling receptor activity
CG479_008295	COG3949	Membrane
CG479_008300	COG0783	Belongs to the Dps family
CG479_008320	COG0523	cobalamin synthesis protein
CG479_008330	COG0803	Belongs to the bacterial solute-binding protein 9 family
CG479_008345	COG1902	pentaerythritol trinitrate reductase activity
CG479_008350	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CG479_008360	COG4166	transmembrane transport
CG479_008365	COG0346	lactoylglutathione lyase activity
CG479_008375	COG5337	Spore coat protein CotH
CG479_008380	COG1051	belongs to the nudix hydrolase family
CG479_008385	COG0586	Pfam SNARE associated Golgi protein
CG479_008390	COG2244	polysaccharide biosynthetic process
CG479_008400	COG0701	Predicted permease
CG479_008405	COG3689	TIGRFAM TIGR03943 family protein
CG479_008410	COG1607	acyl-coa hydrolase
CG479_008420	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CG479_008430	COG1028	Short-chain dehydrogenase reductase Sdr
CG479_008440	COG2839	Protein conserved in bacteria
CG479_008445	COG1253	flavin adenine dinucleotide binding
CG479_008460	COG1114	Component of the transport system for branched-chain amino acids
CG479_008480	COG0860	N-Acetylmuramoyl-L-alanine amidase
CG479_008490	COG1876	peptidase activity
CG479_008520	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CG479_008525	COG1819	glycosyl
CG479_008530	COG1819	glycosyl
CG479_008535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG479_008580	COG4499	WXG100 protein secretion system (Wss), protein YukC
CG479_008640	COG3874	Sporulation protein YtfJ
CG479_008665	COG2226	methyltransferase
CG479_008690	COG0386	Belongs to the glutathione peroxidase family
CG479_008720	COG0640	Transcriptional regulator
CG479_008725	COG0798	PFAM Bile acid sodium symporter
CG479_008730	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CG479_008775	COG1418	mRNA catabolic process
CG479_008780	COG0488	(ABC) transporter
CG479_008790	COG0629	single-stranded DNA binding
CG479_008795	COG1413	lyase activity
CG479_008810	COG2521	methyltransferase
CG479_008810	COG2136	Putative SAM-dependent methyltransferase
CG479_008815	COG0018	arginyl-trna synthetase
CG479_008825	COG0733	neurotransmitter:sodium symporter activity
CG479_008845	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG479_008850	COG0477	Major facilitator Superfamily
CG479_008865	COG1454	alcohol dehydrogenase
CG479_008870	COG2610	gluconate transmembrane transporter activity
CG479_008880	COG0456	acetyltransferase
CG479_008885	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CG479_008895	COG1131	(ABC) transporter
CG479_008900	COG4473	ABC transporter
CG479_008915	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG479_008920	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CG479_008930	COG0768	penicillin binding
CG479_008940	COG0204	Acyl-transferase
CG479_008950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CG479_008955	COG0805	protein transport
CG479_008965	COG1307	EDD domain protein, DegV family
CG479_008975	COG1999	signal sequence binding
CG479_008980	COG0071	Belongs to the small heat shock protein (HSP20) family
CG479_008985	COG0367	asparagine synthase
CG479_009000	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CG479_009025	COG0071	Belongs to the small heat shock protein (HSP20) family
CG479_009035	COG1737	Transcriptional regulator
CG479_009040	COG1070	Carbohydrate kinase
CG479_009050	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CG479_009105	COG1151	hydroxylamine reductase activity
CG479_009115	COG1253	flavin adenine dinucleotide binding
CG479_009120	COG5506	Protein of unknown function (DUF1694)
CG479_009140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CG479_009145	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CG479_009150	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CG479_009155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CG479_009165	COG3829	transcription factor binding
CG479_009175	COG1509	lysine 2,3-aminomutase activity
CG479_009185	COG4479	Belongs to the UPF0346 family
CG479_009190	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CG479_009220	COG1357	PFAM Pentapeptide repeats (8 copies)
CG479_009220	COG0515	serine threonine protein kinase
CG479_009225	COG0671	phosphoesterase, PA-phosphatase related
CG479_009230	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CG479_009235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG479_009280	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CG479_009290	COG0726	polysaccharide deacetylase
CG479_009295	COG1408	metallophosphoesterase
CG479_009300	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CG479_009305	COG2323	membrane
CG479_009310	COG0671	phosphoesterase, PA-phosphatase related
CG479_009320	COG1280	lysine exporter protein (LysE YggA)
CG479_009325	COG3403	YqcI/YcgG family
CG479_009355	COG4499	WXG100 protein secretion system (Wss), protein YukC
CG479_009355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG479_009365	COG0372	Belongs to the citrate synthase family
CG479_009370	COG2079	MmgE PrpD family protein
CG479_009375	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CG479_009380	COG1960	acyl-CoA dehydrogenase activity
CG479_009385	COG2084	Dehydrogenase
CG479_009390	COG1012	belongs to the aldehyde dehydrogenase family
CG479_009400	COG1280	lysine exporter protein (LysE YggA)
CG479_009420	COG0420	3'-5' exonuclease activity
CG479_009425	COG0419	ATPase involved in DNA repair
CG479_009430	COG3104	oligopeptide transport
CG479_009455	COG1131	(ABC) transporter
CG479_009475	COG1131	(ABC) transporter
CG479_009480	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CG479_009500	COG1942	4-Oxalocrotonate Tautomerase
CG479_009515	COG1028	Short-chain dehydrogenase reductase Sdr
CG479_009520	COG1169	isochorismate synthase
CG479_009525	COG1021	2,3-dihydroxybenzoate-AMP ligase
CG479_009530	COG1535	isochorismatase
CG479_009530	COG3433	isochorismatase activity
CG479_009535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CG479_009540	COG3251	PFAM MbtH domain protein
CG479_009545	COG2814	Major facilitator Superfamily
CG479_009560	COG0776	regulation of translation
CG479_009575	COG2329	Antibiotic biosynthesis monooxygenase
CG479_009580	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CG479_009615	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CG479_009625	COG0667	Aldo Keto reductase
CG479_009645	COG0010	Belongs to the arginase family
CG479_009655	COG1132	(ABC) transporter
CG479_009660	COG1132	(ABC) transporter
CG479_009690	COG1649	PFAM Uncharacterised BCR, COG1649
CG479_009705	COG2971	BadF BadG BcrA BcrD
CG479_009725	COG0588	phosphoglycerate mutase activity
CG479_009755	COG2195	Cleaves the N-terminal amino acid of tripeptides
CG479_009765	COG1960	acyl-CoA dehydrogenase activity
CG479_009770	COG0439	Biotin carboxylase
CG479_009775	COG0511	ligase activity, forming carbon-carbon bonds
CG479_009780	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CG479_009785	COG1024	Enoyl-CoA hydratase
CG479_009790	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CG479_009795	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CG479_009805	COG1216	Glycosyl transferase, family 2
CG479_009810	COG0640	Transcriptional regulator
CG479_009825	COG1686	Belongs to the peptidase S11 family
CG479_009830	COG5002	protein histidine kinase activity
CG479_009865	COG0789	Transcriptional regulator
CG479_009890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CG479_009900	COG1028	Short-chain dehydrogenase reductase Sdr
CG479_009920	COG0475	glutathione-regulated potassium exporter activity
CG479_009925	COG0475	glutathione-regulated potassium exporter activity
CG479_009945	COG1309	transcriptional regulator
CG479_009965	COG2002	toxin-antitoxin pair type II binding
CG479_009970	COG3409	Peptidoglycan-binding domain 1 protein
CG479_009970	COG3773	Cell wall hydrolase
CG479_009985	COG0693	protein deglycase activity
CG479_009990	COG0201	protein transport
CG479_010010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CG479_010015	COG0322	excinuclease ABC activity
CG479_010025	COG4667	esterase of the alpha-beta hydrolase superfamily
CG479_010065	COG2223	nitrite transmembrane transporter activity
CG479_010115	COG1216	Glycosyl transferase, family 2
CG479_010130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG479_010135	COG1279	arginine transmembrane transporter activity
CG479_010175	COG1794	racemase activity, acting on amino acids and derivatives
CG479_010185	COG2828	Protein conserved in bacteria
CG479_010190	COG5002	protein histidine kinase activity
CG479_010195	COG0561	phosphatase activity
CG479_010215	COG2124	cytochrome p450
CG479_010250	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CG479_010255	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG479_010265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG479_010275	COG2959	enzyme of heme biosynthesis
CG479_010280	COG3773	Cell wall hydrolase
CG479_010280	COG3409	Peptidoglycan-binding domain 1 protein
CG479_010305	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CG479_010310	COG3844	kynureninase activity
CG479_010320	COG1028	Short-chain dehydrogenase reductase Sdr
CG479_010330	COG4176	ABC-type proline glycine betaine transport system permease component
CG479_010335	COG4175	Glycine betaine
CG479_010335	COG0517	IMP dehydrogenase activity
CG479_010365	COG2153	protein acetylation
CG479_010395	COG0514	ATP-dependent DNA helicase (RecQ)
CG479_010415	COG4637	Psort location Cytoplasmic, score
CG479_010420	COG1227	inorganic diphosphatase activity
CG479_010430	COG3397	chitin binding
CG479_010470	COG4166	transmembrane transport
CG479_010480	COG4948	Mandelate Racemase Muconate Lactonizing
CG479_010510	COG1131	(ABC) transporter
CG479_010515	COG1994	Peptidase M50
CG479_010550	COG1307	EDD domain protein, DegV family
CG479_010615	COG5444	nuclease activity
CG479_010730	COG2261	transglycosylase associated protein
CG479_010760	COG0436	Aminotransferase
CG479_010775	COG3973	AAA domain
CG479_010785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG479_010810	COG0628	permease
CG479_010825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CG479_010830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG479_010835	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CG479_010850	COG2746	aminoglycoside 3-N-acetyltransferase activity
CG479_010870	COG0454	-acetyltransferase
CG479_010870	COG0456	acetyltransferase
CG479_010880	COG0726	polysaccharide deacetylase
CG479_010885	COG3037	sugar-specific permease SgaT UlaA
CG479_010895	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG479_010900	COG1368	sulfuric ester hydrolase activity
CG479_010905	COG0488	(ABC) transporter
CG479_010910	COG1605	Chorismate mutase
CG479_010910	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CG479_010930	COG0346	lactoylglutathione lyase activity
CG479_010940	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CG479_010980	COG2329	Antibiotic biosynthesis monooxygenase
CG479_010995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG479_011020	COG0494	nUDIX hydrolase
CG479_011035	COG0456	acetyltransferase
CG479_011055	COG0697	spore germination
CG479_011060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG479_011070	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CG479_011085	COG0730	response to heat
CG479_011095	COG0833	amino acid
CG479_011120	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CG479_011135	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CG479_011140	COG1984	allophanate hydrolase subunit 2
CG479_011145	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CG479_011150	COG1414	Transcriptional regulator
CG479_011165	COG1960	acyl-CoA dehydrogenase activity
CG479_011195	COG0346	lactoylglutathione lyase activity
CG479_011205	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CG479_011210	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CG479_011215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CG479_011220	COG0438	transferase activity, transferring glycosyl groups
CG479_011235	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG479_011240	COG0438	transferase activity, transferring glycosyl groups
CG479_011245	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG479_011255	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CG479_011275	COG4851	CamS sex pheromone cAM373 precursor
CG479_011345	COG0477	Major facilitator Superfamily
CG479_011360	COG1846	Transcriptional regulator
CG479_011365	COG2814	Major facilitator Superfamily
CG479_011375	COG2031	fatty acid transporter
CG479_011405	COG1122	ATPase activity
CG479_011430	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CG479_011445	COG1131	(ABC) transporter
CG479_011505	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CG479_011510	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG479_011515	COG0579	oxidoreductase
CG479_011520	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CG479_011530	COG1253	flavin adenine dinucleotide binding
CG479_011535	COG0789	Transcriptional regulator
CG479_011540	COG3813	Protein conserved in bacteria
CG479_011555	COG0384	phenazine biosynthesis protein PhzF
CG479_011620	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CG479_011660	COG1136	(ABC) transporter
CG479_011660	COG0577	efflux transmembrane transporter activity
CG479_011725	COG4591	ABC-type transport system involved in lipoprotein release permease component
CG479_011730	COG0577	efflux transmembrane transporter activity
CG479_011730	COG1136	(ABC) transporter
CG479_011775	COG2076	Multidrug Resistance protein
CG479_011790	COG2072	flavoprotein involved in K transport
CG479_011820	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CG479_011825	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CG479_011840	COG1193	negative regulation of DNA recombination
CG479_011845	COG2162	N-hydroxyarylamine O-acetyltransferase activity
CG479_011850	COG1164	Oligoendopeptidase f
CG479_011870	COG0584	glycerophosphoryl diester phosphodiesterase
CG479_011875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG479_011905	COG3397	chitin binding
CG479_011915	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CG479_011920	COG0277	FAD linked oxidase domain protein
CG479_011925	COG1285	pathogenesis
CG479_011930	COG2720	vancomycin resistance protein
CG479_011950	COG1278	Cold shock
CG479_011960	COG1028	Short-chain dehydrogenase reductase Sdr
CG479_011965	COG0165	Argininosuccinate lyase
CG479_011980	COG4145	pantothenate transmembrane transporter activity
CG479_011985	COG3924	membrane
CG479_011990	COG1012	belongs to the aldehyde dehydrogenase family
CG479_012000	COG1657	PFAM Prenyltransferase squalene oxidase
CG479_012005	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CG479_012010	COG2962	Rard protein
CG479_012045	COG2226	methyltransferase
CG479_012050	COG4166	transmembrane transport
CG479_012055	COG4166	transmembrane transport
CG479_012060	COG1301	dicarboxylic acid transport
CG479_012065	COG0673	inositol 2-dehydrogenase activity
CG479_012070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CG479_012075	COG0187	DNA topoisomerase II activity
CG479_012085	COG1832	CoA-binding protein
CG479_012090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CG479_012095	COG0745	RESPONSE REGULATOR receiver
CG479_012110	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CG479_012115	COG4841	protein insertion into membrane
CG479_012120	COG0824	Thioesterase
CG479_012150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG479_012155	COG3655	Transcriptional regulator
CG479_012175	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CG479_012185	COG0726	polysaccharide deacetylase
CG479_012215	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CG479_012220	COG0318	PFAM AMP-dependent synthetase and ligase
CG479_012250	COG0457	Tetratricopeptide repeat
CG479_012325	COG2826	transposase and inactivated derivatives, IS30 family
CG479_012340	COG0534	Mate efflux family protein
CG479_012370	COG3023	N-Acetylmuramoyl-L-alanine amidase
CG479_012380	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG479_012390	COG5002	protein histidine kinase activity
CG479_012395	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG479_012400	COG0010	Belongs to the arginase family
CG479_012405	COG1228	amidohydrolase
CG479_012410	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CG479_012415	COG2986	histidine ammonia-lyase
CG479_012435	COG4846	Membrane protein involved in cytochrome C biogenesis
CG479_012440	COG0785	Cytochrome C biogenesis protein
CG479_012455	COG0583	DNA-binding transcription factor activity
CG479_012460	COG1380	Effector of murein hydrolase LrgA
CG479_012465	COG1346	cytolysis
CG479_012470	COG4187	Peptidase family M20/M25/M40
CG479_012480	COG0833	amino acid
CG479_012490	COG0730	response to heat
CG479_012500	COG5632	N-Acetylmuramoyl-L-alanine amidase
CG479_012500	COG3409	Peptidoglycan-binding domain 1 protein
CG479_012515	COG1132	(ABC) transporter
CG479_012520	COG1132	(ABC) transporter
CG479_012525	COG3763	UPF0154 protein
CG479_012540	COG3639	organic phosphonate transmembrane transporter activity
CG479_012545	COG3639	organic phosphonate transmembrane transporter activity
CG479_012560	COG0737	Belongs to the 5'-nucleotidase family
CG479_012565	COG4224	UPF0291 protein
CG479_012570	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CG479_012575	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CG479_012590	COG1695	Transcriptional regulator
CG479_012630	COG3328	transposase activity
CG479_012635	COG3328	transposase activity
CG479_012640	COG3328	transposase activity
CG479_012655	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG479_012670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CG479_012680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG479_012700	COG0730	response to heat
CG479_012755	COG0174	glutamine synthetase
CG479_012760	COG0789	Transcriptional regulator
CG479_012765	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CG479_012770	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CG479_012775	COG2860	membrane
CG479_012780	COG0464	growth
CG479_012795	COG1923	regulation of RNA biosynthetic process
CG479_012800	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CG479_012810	COG3584	3D domain protein
CG479_012810	COG1388	LysM domain
CG479_012815	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG479_012815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG479_012815	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG479_012820	COG1105	Belongs to the carbohydrate kinase PfkB family
CG479_012825	COG1349	DNA-binding transcription factor activity
CG479_012830	COG2322	membrane
CG479_012855	COG2116	formate transmembrane transporter activity
CG479_012865	COG1937	Protein conserved in bacteria
CG479_012870	COG2819	hydrolase of the alpha beta superfamily
CG479_012875	COG1120	ATPase activity
CG479_012880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG479_012885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG479_012890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG479_012895	COG2706	6-phosphogluconolactonase activity
CG479_012900	COG2195	Cleaves the N-terminal amino acid of tripeptides
CG479_012910	COG0346	lactoylglutathione lyase activity
CG479_012925	COG1113	amino acid transport
CG479_012950	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CG479_012955	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CG479_012965	COG4550	Control of competence regulator ComK, YlbF/YmcA
CG479_012970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CG479_012975	COG1013	pyruvate-flavodoxin oxidoreductase activity
CG479_012980	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CG479_012980	COG0674	pyruvate-flavodoxin oxidoreductase activity
CG479_012990	COG2359	stage V sporulation protein S
CG479_012995	COG1692	metallophosphoesterase
CG479_013000	COG1418	mRNA catabolic process
CG479_013005	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CG479_013010	COG1058	Belongs to the CinA family
CG479_013010	COG1546	Belongs to the CinA family
CG479_013015	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CG479_013020	COG1426	Protein conserved in bacteria
CG479_013035	COG0300	oxidoreductase activity
CG479_013040	COG0612	Peptidase, M16
CG479_013045	COG0612	Peptidase, M16
CG479_013070	COG2188	Transcriptional regulator
CG479_013075	COG1674	ftsk spoiiie
CG479_013090	COG0740	serine-type endopeptidase activity
CG479_013095	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CG479_013110	COG0527	aspartate kinase activity
CG479_013115	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CG479_013120	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CG479_013125	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CG479_013130	COG1873	PFAM PRC-barrel domain
CG479_013135	COG0612	Peptidase, M16
CG479_013140	COG0726	polysaccharide deacetylase
CG479_013145	COG1185	polyribonucleotide nucleotidyltransferase activity
CG479_013155	COG0196	riboflavin kinase activity
CG479_013160	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CG479_013165	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CG479_013170	COG1550	Protein conserved in bacteria
CG479_013175	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CG479_013180	COG1358	cellular component organization or biogenesis
CG479_013185	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CG479_013190	COG0195	Participates in both transcription termination and antitermination
CG479_013195	COG0779	Required for maturation of 30S ribosomal subunits
CG479_013205	COG0442	prolyl-tRNA aminoacylation
CG479_013210	COG0750	zinc metalloprotease
CG479_013220	COG4589	Belongs to the CDS family
CG479_013230	COG0233	cytoplasmic translational termination
CG479_013235	COG0528	UMP kinase activity
CG479_013240	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CG479_013245	COG0052	Belongs to the universal ribosomal protein uS2 family
CG479_013250	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CG479_013255	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CG479_013260	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CG479_013265	COG4974	Belongs to the 'phage' integrase family
CG479_013270	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CG479_013275	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CG479_013280	COG0758	DNA mediated transformation
CG479_013285	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CG479_013290	COG0045	succinate-CoA ligase (ADP-forming) activity
CG479_013295	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CG479_013310	COG0335	large ribosomal subunit rRNA binding
CG479_013320	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CG479_013325	COG1837	Belongs to the UPF0109 family
CG479_013330	COG0228	four-way junction DNA binding
CG479_013335	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CG479_013340	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CG479_013345	COG0552	protein localization to endoplasmic reticulum
CG479_013350	COG1196	nuclear chromosome segregation
CG479_013355	COG0571	ribonuclease III activity
CG479_013365	COG1028	Short-chain dehydrogenase reductase Sdr
CG479_013370	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CG479_013375	COG0416	fatty acid biosynthetic process
CG479_013380	COG2050	protein possibly involved in aromatic compounds catabolism
CG479_013380	COG1349	DNA-binding transcription factor activity
CG479_013385	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CG479_013390	COG1461	Dihydroxyacetone kinase
CG479_013395	COG1302	Protein conserved in bacteria
CG479_013400	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CG479_013410	COG1564	THIamine pyrophosphokinase
CG479_013415	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CG479_013420	COG1162	GTPase activity
CG479_013425	COG0515	serine threonine protein kinase
CG479_013425	COG2815	serine threonine protein kinase
CG479_013430	COG0631	protein serine/threonine phosphatase activity
CG479_013435	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CG479_013440	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CG479_013440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CG479_013445	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CG479_013450	COG0242	peptide deformylase activity
CG479_013455	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CG479_013465	COG1758	RNA polymerase activity
CG479_013470	COG0194	GDP metabolic process
CG479_013480	COG1561	YicC-like family, N-terminal region
CG479_013485	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CG479_013510	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CG479_013515	COG0284	orotidine-5'-phosphate decarboxylase activity
CG479_013520	COG0167	dihydroorotate dehydrogenase activity
CG479_013525	COG0543	2 iron, 2 sulfur cluster binding
CG479_013530	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CG479_013540	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CG479_013545	COG0540	Belongs to the ATCase OTCase family
CG479_013555	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CG479_013565	COG0564	pseudouridine synthase activity
CG479_013570	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CG479_013580	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CG479_013585	COG3599	regulation of cell shape
CG479_013590	COG2302	S4 RNA-binding domain
CG479_013595	COG0762	integral membrane protein
CG479_013600	COG1799	cell septum assembly
CG479_013605	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CG479_013615	COG1873	PFAM PRC-barrel domain
CG479_013620	COG1191	sigma factor activity
CG479_013625	COG1191	sigma factor activity
CG479_013635	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CG479_013640	COG0849	cell division
CG479_013645	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CG479_013655	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CG479_013660	COG0772	Belongs to the SEDS family
CG479_013665	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CG479_013670	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CG479_013675	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CG479_013680	COG0768	penicillin binding
CG479_013690	COG4839	cell division protein FtsL
CG479_013695	COG0275	rRNA processing
CG479_013700	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CG479_013705	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CG479_013725	COG1399	metal-binding, possibly nucleic acid-binding protein
CG479_013835	COG4626	Terminase
CG479_013835	COG1802	Transcriptional regulator
CG479_013925	COG0756	dUTP diphosphatase activity
CG479_013955	COG3723	Recombinational DNA repair protein, rece pathway
CG479_013965	COG5377	YqaJ viral recombinase family
CG479_014010	COG0582	viral genome integration into host DNA
CG479_014015	COG1323	Belongs to the UPF0348 family
CG479_014020	COG3480	Lon protease (S16) C-terminal proteolytic domain
CG479_014025	COG1752	Esterase of the alpha-beta hydrolase superfamily
CG479_014030	COG3314	Sporulation integral membrane protein YlbJ
CG479_014035	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CG479_014040	COG0742	ribosomal rna small subunit methyltransferase
CG479_014050	COG4471	UPF0298 protein
CG479_014055	COG3679	Belongs to the UPF0342 family
CG479_014060	COG0406	alpha-ribazole phosphatase activity
CG479_014075	COG2340	Cysteine-rich secretory protein family
CG479_014085	COG3336	cytochrome c oxidase
CG479_014110	COG0109	protoheme IX farnesyltransferase activity
CG479_014115	COG1612	heme a metabolic process
CG479_014120	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CG479_014130	COG0772	Belongs to the SEDS family
CG479_014135	COG4838	Belongs to the UPF0358 family
CG479_014140	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CG479_014145	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CG479_014155	COG4896	Protein conserved in bacteria
CG479_014180	COG0483	inositol monophosphate 1-phosphatase activity
CG479_014190	COG4493	Belongs to the UPF0637 family
CG479_014195	COG4476	Belongs to the UPF0223 family
CG479_014200	COG1982	Orn Lys Arg decarboxylase major
CG479_014240	COG0508	dehydrogenase complex catalyzes the overall conversion of
CG479_014250	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CG479_014265	COG0561	phosphatase activity
CG479_014280	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CG479_014285	COG0569	domain protein
CG479_014295	COG1473	amidohydrolase
CG479_014300	COG2171	N-acyltransferase activity
CG479_014305	COG0583	DNA-binding transcription factor activity
CG479_014310	COG0517	IMP dehydrogenase activity
CG479_014320	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CG479_014335	COG4703	Protein of unknown function (DUF1797)
CG479_014350	COG2200	EAL domain
CG479_014355	COG1028	Short-chain dehydrogenase reductase Sdr
CG479_014360	COG1408	metallophosphoesterase
CG479_014370	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CG479_014390	COG0726	polysaccharide deacetylase
CG479_014410	COG2814	Major facilitator Superfamily
CG479_014415	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CG479_014425	COG3209	COG3209 Rhs family protein
CG479_014435	COG2205	protein histidine kinase activity
CG479_014445	COG0436	Aminotransferase
CG479_014450	COG1609	Transcriptional regulator
CG479_014455	COG3833	ABC-type maltose transport systems, permease component
CG479_014460	COG1175	transmembrane transport
CG479_014465	COG2182	Extracellular solute-binding protein
CG479_014485	COG0366	Alpha amylase catalytic
CG479_014490	COG3842	ATPase activity
CG479_014520	COG0183	Belongs to the thiolase family
CG479_014550	COG1695	Transcriptional regulator
CG479_014555	COG1028	Short-chain dehydrogenase reductase Sdr
CG479_014565	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CG479_014570	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CG479_014575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CG479_014580	COG0436	Aminotransferase
CG479_014585	COG1850	ribulose-bisphosphate carboxylase activity
CG479_014590	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
CG479_014595	COG0235	Class ii aldolase
CG479_014600	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CG479_014615	COG2084	Dehydrogenase
CG479_014630	COG0778	Nitroreductase
CG479_014655	COG2190	(PTS) system
CG479_014655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG479_014655	COG1263	PTS System
CG479_014660	COG3711	transcriptional antiterminator
CG479_014675	COG0363	glucosamine-6-phosphate deaminase activity
CG479_014690	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CG479_014695	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CG479_014705	COG1547	Domain of unknown function (DUF309)
CG479_014715	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CG479_014720	COG4086	secreted protein
CG479_014725	COG0561	phosphatase activity
CG479_014730	COG0697	spore germination
CG479_014745	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CG479_014770	COG0733	neurotransmitter:sodium symporter activity
CG479_014780	COG2172	sigma factor antagonist activity
CG479_014790	COG1686	Belongs to the peptidase S11 family
CG479_014800	COG1725	Transcriptional regulator
CG479_014805	COG1131	(ABC) transporter
CG479_014830	COG1846	Transcriptional regulator
CG479_014845	COG0598	Magnesium transport protein CorA
CG479_014875	COG4974	Belongs to the 'phage' integrase family
CG479_014885	COG0735	belongs to the Fur family
CG479_014890	COG1300	Membrane
CG479_014910	COG0667	Aldo Keto reductase
CG479_014915	COG0656	L-ascorbic acid biosynthetic process
CG479_014920	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CG479_014920	COG0456	acetyltransferase
CG479_014930	COG1525	nuclease
CG479_014930	COG4085	toxin activity
CG479_014930	COG0737	Belongs to the 5'-nucleotidase family
CG479_014940	COG0596	Alpha beta hydrolase
CG479_014945	COG2056	Na+-H+ antiporter family
CG479_014950	COG1609	Transcriptional regulator
CG479_014955	COG0456	acetyltransferase
CG479_014960	COG1073	alpha beta
CG479_014975	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CG479_014975	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CG479_014980	COG0307	riboflavin synthase, alpha
CG479_014985	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CG479_014985	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CG479_015000	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CG479_015005	COG4106	trans-aconitate 2-methyltransferase activity
CG479_015010	COG0596	Alpha beta hydrolase
CG479_015015	COG0156	8-amino-7-oxononanoate synthase activity
CG479_015025	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CG479_015040	COG0737	Belongs to the 5'-nucleotidase family
CG479_015065	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CG479_015075	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CG479_015085	COG0300	oxidoreductase activity
CG479_015090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG479_015095	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CG479_015100	COG1760	l-serine dehydratase
CG479_015105	COG1760	l-serine dehydratase
CG479_015115	COG1234	tRNA 3'-trailer cleavage
CG479_015140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG479_015155	COG1376	ErfK ybiS ycfS ynhG family protein
CG479_015160	COG4129	membrane
CG479_015165	COG1126	abc transporter atp-binding protein
CG479_015170	COG0765	amino acid transport
CG479_015175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG479_015190	COG2816	NAD+ diphosphatase activity
CG479_015195	COG0772	Belongs to the SEDS family
CG479_015205	COG0508	dehydrogenase complex catalyzes the overall conversion of
CG479_015210	COG0022	dehydrogenase e1 component
CG479_015215	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CG479_015220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CG479_015225	COG3426	butyrate kinase activity
CG479_015230	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CG479_015235	COG0280	phosphate acetyltransferase
CG479_015245	COG3290	protein histidine kinase activity
CG479_015245	COG3829	transcription factor binding
CG479_015255	COG0584	glycerophosphoryl diester phosphodiesterase
CG479_015260	COG3093	addiction module antidote protein HigA
CG479_015265	COG0745	RESPONSE REGULATOR receiver
CG479_015270	COG0750	zinc metalloprotease
CG479_015275	COG0497	DNA recombination
CG479_015285	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CG479_015290	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CG479_015300	COG1722	exodeoxyribonuclease VII activity
CG479_015305	COG1570	exodeoxyribonuclease VII activity
CG479_015310	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CG479_015315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CG479_015320	COG1302	Protein conserved in bacteria
CG479_015325	COG0439	Biotin carboxylase
CG479_015330	COG0511	ligase activity, forming carbon-carbon bonds
CG479_015375	COG3854	ATPases associated with a variety of cellular activities
CG479_015395	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CG479_015400	COG0006	proline dipeptidase activity
CG479_015405	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CG479_015415	COG3872	metal-dependent enzyme
CG479_015425	COG1321	iron dependent repressor
CG479_015440	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CG479_015450	COG1609	Transcriptional regulator
CG479_015460	COG2076	Multidrug Resistance protein
CG479_015465	COG2076	Multidrug Resistance protein
CG479_015490	COG1131	(ABC) transporter
CG479_015495	COG1725	Transcriptional regulator
CG479_015510	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CG479_015515	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CG479_015520	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CG479_015525	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CG479_015555	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CG479_015580	COG1459	type II secretion system
CG479_015605	COG4824	toxin secretion phage lysis holin
CG479_015690	COG3728	DNA packaging
CG479_015700	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CG479_015765	COG1484	DNA-dependent DNA replication
CG479_015780	COG3723	Recombinational DNA repair protein, rece pathway
CG479_015785	COG5377	YqaJ viral recombinase family
CG479_015810	COG1396	sequence-specific DNA binding
CG479_015825	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CG479_015860	COG1078	dGTPase activity
CG479_015875	COG1410	methionine synthase
CG479_015875	COG0646	methionine synthase
CG479_015880	COG0646	methionine synthase
CG479_015880	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CG479_015885	COG0626	cystathionine gamma-synthase activity
CG479_015890	COG0626	cystathionine gamma-synthase activity
CG479_015910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG479_015920	COG1940	carbohydrate kinase activity
CG479_015925	COG4483	Protein conserved in bacteria
CG479_015930	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CG479_015935	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CG479_015940	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CG479_015945	COG0704	Plays a role in the regulation of phosphate uptake
CG479_015950	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CG479_015955	COG0581	inorganic phosphate transmembrane transporter activity
CG479_015960	COG0573	inorganic phosphate transmembrane transporter activity
CG479_015965	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CG479_015975	COG0477	Major facilitator Superfamily
CG479_015980	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CG479_016000	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CG479_016005	COG0735	belongs to the Fur family
CG479_016010	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CG479_016015	COG1121	(ABC) transporter
CG479_016020	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG479_016030	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CG479_016045	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CG479_016050	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CG479_016055	COG2384	SAM-dependent methyltransferase
CG479_016065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CG479_016070	COG0358	DNA primase activity
CG479_016075	COG1671	Belongs to the UPF0178 family
CG479_016080	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CG479_016085	COG0517	IMP dehydrogenase activity
CG479_016090	COG1381	Involved in DNA repair and RecF pathway recombination
CG479_016100	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CG479_016110	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CG479_016115	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CG479_016120	COG1480	7TM receptor with intracellular HD hydrolase
CG479_016125	COG1702	phosphate starvation-inducible protein PhoH
CG479_016140	COG1610	YqeY-like protein
CG479_016145	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CG479_016150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CG479_016155	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CG479_016160	COG2264	protein methyltransferase activity
CG479_016165	COG0484	heat shock protein binding
CG479_016170	COG0443	Heat shock 70 kDa protein
CG479_016175	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CG479_016180	COG1420	regulation of RNA biosynthetic process
CG479_016185	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CG479_016190	COG1733	regulation of RNA biosynthetic process
CG479_016195	COG0693	protein deglycase activity
CG479_016200	COG0481	GTPase activity
CG479_016210	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CG479_016215	COG0268	Binds directly to 16S ribosomal RNA
CG479_016220	COG1466	dna polymerase III delta subunit
CG479_016230	COG2333	competence protein COMEC
CG479_016230	COG0658	competence protein
CG479_016235	COG2131	deaminase
CG479_016240	COG1555	photosystem II stabilization
CG479_016240	COG1596	polysaccharide export
CG479_016245	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CG479_016250	COG2226	methyltransferase
CG479_016255	COG0799	negative regulation of ribosome biogenesis
CG479_016260	COG1713	HD superfamily hydrolase involved in NAD metabolism
CG479_016265	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CG479_016270	COG1534	Rna-binding protein
CG479_016275	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CG479_016280	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CG479_016285	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CG479_016295	COG0688	phosphatidylethanolamine metabolic process
CG479_016300	COG1191	sigma factor activity
CG479_016310	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CG479_016315	COG2357	RelA SpoT domain protein
CG479_016320	COG1785	Belongs to the alkaline phosphatase family
CG479_016325	COG0456	acetyltransferase
CG479_016330	COG2267	carboxylic ester hydrolase activity
CG479_016355	COG3186	Phenylalanine-4-hydroxylase
CG479_016360	COG2154	pterin-4-alpha-carbinolamine dehydratase
CG479_016365	COG2514	catechol 2,3-dioxygenase activity
CG479_016370	COG2259	Doxx family
CG479_016390	COG1609	Transcriptional regulator
CG479_016400	COG0626	cystathionine gamma-synthase activity
CG479_016405	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CG479_016410	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CG479_016415	COG2226	methyltransferase
CG479_016430	COG0768	penicillin binding
CG479_016440	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CG479_016445	COG0572	uridine kinase
CG479_016465	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CG479_016475	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CG479_016480	COG4472	Bacterial protein of unknown function (DUF965)
CG479_016485	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CG479_016490	COG0628	permease
CG479_016510	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CG479_016520	COG0482	sulfurtransferase activity
CG479_016525	COG1104	cysteine desulfurase activity
CG479_016530	COG1959	2 iron, 2 sulfur cluster binding
CG479_016535	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CG479_016555	COG2207	Transcriptional regulator
CG479_016565	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CG479_016575	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CG479_016580	COG0124	histidyl-tRNA synthetase
CG479_016600	COG1490	D-aminoacyl-tRNA deacylase activity
CG479_016605	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CG479_016610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CG479_016615	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CG479_016615	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CG479_016620	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CG479_016625	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CG479_016625	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CG479_016635	COG2244	polysaccharide biosynthetic process
CG479_016660	COG1862	Preprotein translocase
CG479_016665	COG0343	queuine tRNA-ribosyltransferase activity
CG479_016670	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CG479_016680	COG2255	four-way junction helicase activity
CG479_016685	COG0632	four-way junction helicase activity
CG479_016690	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CG479_016710	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CG479_016715	COG0157	Belongs to the NadC ModD family
CG479_016720	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CG479_016725	COG1104	cysteine desulfurase activity
CG479_016730	COG1827	regulation of RNA biosynthetic process
CG479_016735	COG2258	MOSC domain
CG479_016740	COG0077	Prephenate dehydratase
CG479_016745	COG0577	efflux transmembrane transporter activity
CG479_016750	COG0577	efflux transmembrane transporter activity
CG479_016755	COG1136	(ABC) transporter
CG479_016760	COG5002	protein histidine kinase activity
CG479_016765	COG0745	RESPONSE REGULATOR receiver
CG479_016775	COG3290	protein histidine kinase activity
CG479_016780	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CG479_016785	COG2868	ribosomal protein
CG479_016795	COG1530	ribonuclease E activity
CG479_016800	COG1994	Peptidase M50
CG479_016805	COG0739	heme binding
CG479_016810	COG2894	cell division
CG479_016815	COG0850	regulation of cytokinetic process
CG479_016825	COG1792	Involved in formation and maintenance of cell shape
CG479_016830	COG1077	Cell shape determining protein MreB Mrl
CG479_016850	COG0424	maF-like protein
CG479_016860	COG0285	dihydrofolate synthase activity
CG479_016885	COG1388	LysM domain
CG479_016885	COG1388	LysM domain
CG479_016890	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CG479_016895	COG0113	porphobilinogen synthase activity
CG479_016900	COG1587	Uroporphyrinogen-III synthase
CG479_016905	COG0181	hydroxymethylbilane synthase activity
CG479_016910	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CG479_016915	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CG479_016920	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CG479_016930	COG1067	ATP-dependent peptidase activity
CG479_016930	COG0470	DNA polymerase III
CG479_016935	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CG479_016940	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG479_016980	COG2409	Drug exporters of the RND superfamily
CG479_016980	COG1033	growth of symbiont in host cell
CG479_016990	COG1309	transcriptional regulator
CG479_017010	COG0622	Phosphoesterase
CG479_017020	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CG479_017025	COG5401	PFAM Sporulation and spore germination
CG479_017035	COG2197	response regulator
CG479_017045	COG1959	2 iron, 2 sulfur cluster binding
CG479_017050	COG1668	transmembrane transport
CG479_017055	COG4152	abc transporter atp-binding protein
CG479_017060	COG1360	Flagellar Motor Protein
CG479_017065	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CG479_017075	COG1876	peptidase activity
CG479_017085	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CG479_017090	COG1053	succinate dehydrogenase
CG479_017095	COG2009	succinate dehydrogenase
CG479_017100	COG1719	4-vinyl reductase, 4VR
CG479_017115	COG3118	belongs to the thioredoxin family
CG479_017120	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CG479_017125	COG2086	electron transfer activity
CG479_017130	COG1024	Enoyl-CoA hydratase
CG479_017135	COG1309	transcriptional regulator
CG479_017140	COG0318	PFAM AMP-dependent synthetase and ligase
CG479_017150	COG2318	DinB family
CG479_017170	COG1131	(ABC) transporter
CG479_017175	COG2205	protein histidine kinase activity
CG479_017180	COG0745	RESPONSE REGULATOR receiver
CG479_017190	COG4895	conserved protein (DUF2196)
CG479_017195	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CG479_017200	COG1114	Component of the transport system for branched-chain amino acids
CG479_017205	COG1187	pseudouridine synthase activity
CG479_017215	COG1193	negative regulation of DNA recombination
CG479_017220	COG1796	DNA polymerase
CG479_017220	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CG479_017225	COG1286	toxin biosynthetic process
CG479_017230	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CG479_017255	COG0017	Asparaginyl-tRNA synthetase
CG479_017260	COG0072	phenylalanine-tRNA ligase activity
CG479_017260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CG479_017265	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CG479_017270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CG479_017280	COG1418	mRNA catabolic process
CG479_017295	COG2814	Major facilitator Superfamily
CG479_017300	COG1566	PFAM secretion protein HlyD family protein
CG479_017305	COG1309	transcriptional regulator
CG479_017310	COG1363	Peptidase, m42
CG479_017320	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CG479_017325	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CG479_017330	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CG479_017335	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CG479_017345	COG1484	DNA-dependent DNA replication
CG479_017350	COG3611	Membrane attachment protein
CG479_017355	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CG479_017360	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CG479_017370	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CG479_017380	COG1971	Probably functions as a manganese efflux pump
CG479_017390	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CG479_017390	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CG479_017395	COG5002	protein histidine kinase activity
CG479_017400	COG0745	RESPONSE REGULATOR receiver
CG479_017410	COG0039	L-malate dehydrogenase activity
CG479_017415	COG0538	isocitrate dehydrogenase activity
CG479_017420	COG0372	Belongs to the citrate synthase family
CG479_017425	COG2707	UPF0756 membrane protein
CG479_017430	COG0628	permease
CG479_017435	COG3030	protein affecting phage T7 exclusion by the F plasmid
CG479_017445	COG0205	6-phosphofructokinase activity
CG479_017450	COG0825	malonyl-CoA metabolic process
CG479_017455	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CG479_017460	COG1725	Transcriptional regulator
CG479_017465	COG0281	malic enzyme
CG479_017470	COG0587	DNA-directed DNA polymerase activity
CG479_017485	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CG479_017495	COG4109	DRTGG domain
CG479_017500	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CG479_017505	COG0006	proline dipeptidase activity
CG479_017530	COG1028	Short-chain dehydrogenase reductase Sdr
CG479_017535	COG0589	response to stress
CG479_017560	COG0165	Argininosuccinate lyase
CG479_017565	COG0137	argininosuccinate synthase activity
CG479_017575	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG479_017585	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CG479_017590	COG0827	DNA restriction-modification system
CG479_017595	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CG479_017600	COG3874	Sporulation protein YtfJ
CG479_017610	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CG479_017615	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CG479_017620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CG479_017630	COG0301	tRNA thio-modification
CG479_017635	COG1104	cysteine desulfurase activity
CG479_017640	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CG479_017645	COG0583	DNA-binding transcription factor activity
CG479_017650	COG0697	spore germination
CG479_017655	COG1309	transcriptional regulator
CG479_017660	COG1956	GAF domain-containing protein
CG479_017665	COG0626	cystathionine gamma-synthase activity
CG479_017675	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CG479_017695	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CG479_017705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CG479_017710	COG0454	-acetyltransferase
CG479_017715	COG0517	IMP dehydrogenase activity
CG479_017720	COG0123	including yeast histone deacetylase and acetoin utilization protein
CG479_017725	COG1970	mechanosensitive ion channel activity
CG479_017735	COG1609	Transcriptional regulator
CG479_017745	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CG479_017745	COG1605	Chorismate mutase
CG479_017750	COG3118	belongs to the thioredoxin family
CG479_017760	COG2309	aminopeptidase activity
CG479_017775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CG479_017785	COG1674	ftsk spoiiie
CG479_017795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CG479_017800	COG4848	Belongs to the UPF0354 family
CG479_017805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG479_017810	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CG479_017820	COG0675	Transposase, IS605 OrfB family
CG479_017830	COG1363	Peptidase, m42
CG479_017840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG479_017845	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CG479_017855	COG0510	thiamine kinase activity
CG479_017860	COG1523	belongs to the glycosyl hydrolase 13 family
CG479_017870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CG479_017875	COG1349	DNA-binding transcription factor activity
CG479_017880	COG1187	pseudouridine synthase activity
CG479_017885	COG2244	polysaccharide biosynthetic process
CG479_017890	COG2081	HI0933 family
CG479_017905	COG3832	glyoxalase III activity
CG479_017925	COG0463	Glycosyl transferase, family 2
CG479_017980	COG1329	Transcriptional regulator
CG479_017990	COG2223	nitrite transmembrane transporter activity
CG479_018000	COG0314	molybdopterin synthase activity
CG479_018005	COG1763	Mo-molybdopterin cofactor biosynthetic process
CG479_018010	COG0303	'Molybdopterin
CG479_018015	COG0315	cyclic pyranopterin monophosphate synthase activity
CG479_018020	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG479_018025	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CG479_018030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CG479_018035	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CG479_018040	COG1140	nitrate reductase beta subunit
CG479_018045	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CG479_018050	COG2181	nitrate reductase activity
CG479_018065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CG479_018075	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CG479_018110	COG0495	leucyl-tRNA aminoacylation
CG479_018115	COG2814	Major facilitator Superfamily
CG479_018125	COG1136	(ABC) transporter
CG479_018130	COG0346	lactoylglutathione lyase activity
CG479_018145	COG1242	4 iron, 4 sulfur cluster binding
CG479_018150	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CG479_018155	COG1121	(ABC) transporter
CG479_018165	COG1794	racemase activity, acting on amino acids and derivatives
CG479_018175	COG2378	regulation of single-species biofilm formation
CG479_018185	COG2267	carboxylic ester hydrolase activity
CG479_018190	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CG479_018200	COG0746	molybdenum cofactor guanylyltransferase activity
CG479_018225	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CG479_018235	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CG479_018280	COG3409	Peptidoglycan-binding domain 1 protein
CG479_018280	COG5632	N-Acetylmuramoyl-L-alanine amidase
CG479_018290	COG1368	sulfuric ester hydrolase activity
CG479_018305	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CG479_018310	COG1116	anion transmembrane transporter activity
CG479_018315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG479_018330	COG0494	nUDIX hydrolase
CG479_018340	COG1854	S-ribosylhomocysteine lyase activity
CG479_018345	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CG479_018350	COG0288	reversible hydration of carbon dioxide
CG479_018355	COG1271	oxidase subunit
CG479_018360	COG1294	oxidase, subunit
CG479_018390	COG1842	Phage shock protein A
CG479_018435	COG1597	lipid kinase activity
CG479_018440	COG1136	(ABC) transporter
CG479_018450	COG0745	RESPONSE REGULATOR receiver
CG479_018455	COG2205	protein histidine kinase activity
CG479_018460	COG0577	efflux transmembrane transporter activity
CG479_018465	COG1136	(ABC) transporter
CG479_018485	COG4948	Mandelate Racemase Muconate Lactonizing
CG479_018490	COG0318	PFAM AMP-dependent synthetase and ligase
CG479_018495	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CG479_018500	COG0596	Alpha beta hydrolase
CG479_018505	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CG479_018510	COG1169	isochorismate synthase
CG479_018515	COG1575	Belongs to the MenA family. Type 1 subfamily
CG479_018520	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CG479_018525	COG1278	Cold shock
CG479_018545	COG0058	SHG alpha-glucan phosphorylase activity
CG479_018550	COG0297	glycogen (starch) synthase activity
CG479_018555	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CG479_018560	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CG479_018565	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CG479_018570	COG0039	L-malate dehydrogenase activity
CG479_018665	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG479_018700	COG1285	pathogenesis
CG479_018705	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CG479_018715	COG0166	Belongs to the GPI family
CG479_018725	COG2155	Conserved Protein
CG479_018730	COG1098	S1 RNA binding domain
CG479_018735	COG0436	Aminotransferase
CG479_018740	COG1522	sequence-specific DNA binding
CG479_018745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CG479_018750	COG2267	carboxylic ester hydrolase activity
CG479_018760	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CG479_018765	COG2032	superoxide dismutase activity
CG479_018775	COG5018	Exonuclease
CG479_018780	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CG479_018785	COG0423	glycine-tRNA ligase activity
CG479_018800	COG2050	protein possibly involved in aromatic compounds catabolism
CG479_018810	COG1268	BioY protein
CG479_018815	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CG479_018820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CG479_018830	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CG479_018840	COG3584	3D domain protein
CG479_018860	COG1252	NADH dehydrogenase
CG479_018865	COG0492	ferredoxin-NADP+ reductase activity
CG479_018880	COG1683	Conserved Protein
CG479_018890	COG0316	Belongs to the HesB IscA family
CG479_018895	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CG479_018900	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG479_018910	COG1252	NADH dehydrogenase
CG479_018915	COG2824	Alkylphosphonate utilization operon protein PhnA
CG479_018925	COG3655	Transcriptional regulator
CG479_018940	COG4837	Protein of unknown function (DUF1462)
CG479_018945	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CG479_018950	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG479_018955	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CG479_018960	COG0647	UMP catabolic process
CG479_018970	COG2445	Protein of unknown function DUF86
CG479_018985	COG4470	Protein conserved in bacteria
CG479_018995	COG0789	Transcriptional regulator
CG479_019000	COG4377	Putative membrane peptidase family (DUF2324)
CG479_019015	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CG479_019020	COG0739	heme binding
CG479_019030	COG3377	Domain of unknown function (DUF1805)
CG479_019035	COG0737	Belongs to the 5'-nucleotidase family
CG479_019055	COG0719	Fe-S assembly protein
CG479_019060	COG0822	iron-sulfur transferase activity
CG479_019065	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CG479_019070	COG0719	Fe-S assembly protein
CG479_019075	COG0396	ATPase activity
CG479_019080	COG1464	Belongs to the NlpA lipoprotein family
CG479_019085	COG2011	ABC-type metal ion transport system permease component
CG479_019100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG479_019105	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CG479_019110	COG0509	glycine decarboxylation via glycine cleavage system
CG479_019115	COG1393	Belongs to the ArsC family
CG479_019155	COG1960	acyl-CoA dehydrogenase activity
CG479_019160	COG0183	Belongs to the thiolase family
CG479_019165	COG1250	3-hydroxyacyl-CoA dehydrogenase
CG479_019165	COG1024	Enoyl-CoA hydratase
CG479_019175	COG1686	Belongs to the peptidase S11 family
CG479_019200	COG0011	TIGRFAM Protein of
CG479_019205	COG0840	transmembrane signaling receptor activity
CG479_019225	COG0531	amino acid
CG479_019230	COG0706	membrane insertase activity
CG479_019240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG479_019250	COG0586	Pfam SNARE associated Golgi protein
CG479_019260	COG1376	ErfK ybiS ycfS ynhG family protein
CG479_019265	COG0745	RESPONSE REGULATOR receiver
CG479_019270	COG5002	protein histidine kinase activity
CG479_019275	COG0840	transmembrane signaling receptor activity
CG479_019280	COG0840	transmembrane signaling receptor activity
CG479_019285	COG2151	metal-sulfur cluster biosynthetic enzyme
CG479_019290	COG3227	Zinc metalloprotease (Elastase)
CG479_019295	COG1741	Belongs to the pirin family
CG479_019310	COG0783	Belongs to the Dps family
CG479_019315	COG1611	Belongs to the LOG family
CG479_019350	COG0803	Belongs to the bacterial solute-binding protein 9 family
CG479_019355	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CG479_019360	COG1121	(ABC) transporter
CG479_019380	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG479_019385	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG479_019390	COG1115	amino acid carrier protein
CG479_019395	COG2910	NAD(P)H-binding
CG479_019410	COG1252	NADH dehydrogenase
CG479_019425	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CG479_019440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CG479_019445	COG4977	sequence-specific DNA binding
CG479_019445	COG1917	Cupin 2, conserved barrel domain protein
CG479_019455	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CG479_019475	COG0697	spore germination
CG479_019485	COG1063	alcohol dehydrogenase
CG479_019495	COG2124	cytochrome p450
CG479_019505	COG2124	cytochrome p450
CG479_019510	COG1309	transcriptional regulator
CG479_019540	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CG479_019545	COG0557	exoribonuclease II activity
CG479_019550	COG1647	Serine aminopeptidase, S33
CG479_019555	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CG479_019560	COG1346	cytolysis
CG479_019570	COG0148	phosphopyruvate hydratase activity
CG479_019575	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CG479_019580	COG0149	triose-phosphate isomerase activity
CG479_019585	COG0126	phosphoglycerate kinase activity
CG479_019590	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CG479_019605	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CG479_019630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CG479_019645	COG2323	membrane
CG479_019655	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG479_019660	COG1481	regulation of sporulation
CG479_019665	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CG479_019670	COG1660	Displays ATPase and GTPase activities
CG479_019675	COG1051	belongs to the nudix hydrolase family
CG479_019685	COG0492	ferredoxin-NADP+ reductase activity
CG479_019690	COG0457	Tetratricopeptide repeat
CG479_019695	COG0110	maltose O-acetyltransferase activity
CG479_019705	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CG479_019710	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CG479_019715	COG1950	PFAM Membrane protein of
CG479_019725	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CG479_019740	COG0789	Transcriptional regulator
CG479_019760	COG0583	DNA-binding transcription factor activity
CG479_019775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CG479_019780	COG0793	Belongs to the peptidase S41A family
CG479_019780	COG3409	Peptidoglycan-binding domain 1 protein
CG479_019785	COG2177	Part of the ABC transporter FtsEX involved in
CG479_019790	COG2884	Cell division ATP-binding protein ftsE
CG479_019825	COG1278	Cold shock
CG479_019830	COG1040	competence protein
CG479_019835	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CG479_019840	COG0791	NLP P60 protein
CG479_019840	COG1388	LysM domain
CG479_019845	COG1733	regulation of RNA biosynthetic process
CG479_019850	COG1307	EDD domain protein, DegV family
CG479_019855	COG1739	Uncharacterized protein family UPF0029
CG479_019860	COG1316	TRANSCRIPTIONal
CG479_019880	COG0457	Tetratricopeptide repeat
CG479_019910	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CG479_019920	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CG479_019930	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CG479_019930	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CG479_019945	COG1486	melibiose metabolic process
CG479_019950	COG1447	Phosphotransferase system cellobiose-specific component IIA
CG479_019965	COG1447	Phosphotransferase system cellobiose-specific component IIA
CG479_019970	COG1301	dicarboxylic acid transport
CG479_019975	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CG479_019985	COG1271	oxidase subunit
CG479_019990	COG1294	oxidase, subunit
CG479_019995	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CG479_020000	COG1620	l-lactate permease
CG479_020005	COG2389	metal-binding protein
CG479_020015	COG1368	sulfuric ester hydrolase activity
CG479_020025	COG0791	NLP P60 protein
CG479_020025	COG1388	LysM domain
CG479_020030	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG479_020040	COG1215	transferase activity, transferring glycosyl groups
CG479_020050	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CG479_020055	COG1388	LysM domain
CG479_020055	COG3584	3D domain protein
CG479_020070	COG4715	Zinc finger, swim domain protein
CG479_020075	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CG479_020115	COG0577	efflux transmembrane transporter activity
CG479_020120	COG1136	(ABC) transporter
CG479_020155	COG3850	Histidine kinase
CG479_020155	COG5002	protein histidine kinase activity
CG479_020160	COG0745	RESPONSE REGULATOR receiver
CG479_020175	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CG479_020185	COG1609	Transcriptional regulator
CG479_020195	COG0739	heme binding
CG479_020210	COG3279	Response regulator of the LytR AlgR family
CG479_020215	COG2385	sporulation resulting in formation of a cellular spore
CG479_020230	COG4836	Membrane
CG479_020235	COG1007	ATP synthesis coupled electron transport
CG479_020240	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG479_020245	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CG479_020250	COG0713	ATP synthesis coupled electron transport
CG479_020255	COG0839	Belongs to the complex I subunit 6 family
CG479_020265	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CG479_020270	COG0649	NAD binding
CG479_020275	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG479_020280	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG479_020285	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG479_020290	COG5001	Diguanylate cyclase
CG479_020290	COG3300	MHYT domain
CG479_020295	COG3300	MHYT domain
CG479_020295	COG5001	Diguanylate cyclase
CG479_020310	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CG479_020315	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CG479_020320	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CG479_020325	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CG479_020330	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CG479_020335	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CG479_020340	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CG479_020365	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CG479_020370	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CG479_020380	COG0698	ribose 5-phosphate isomerase
CG479_020400	COG2190	(PTS) system
CG479_020405	COG2259	Doxx family
CG479_020410	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CG479_020425	COG0009	L-threonylcarbamoyladenylate synthase
CG479_020440	COG2890	protein-(glutamine-N5) methyltransferase activity
CG479_020445	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CG479_020450	COG1435	thymidine kinase activity
CG479_020460	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CG479_020465	COG1494	fructose-1,6-bisphosphatase
CG479_020485	COG4821	SIS domain
CG479_020490	COG0504	CTP synthase activity
CG479_020505	COG1960	acyl-CoA dehydrogenase activity
CG479_020510	COG1960	acyl-CoA dehydrogenase activity
CG479_020515	COG1250	3-hydroxyacyl-CoA dehydrogenase
CG479_020520	COG0183	Belongs to the thiolase family
CG479_020525	COG2181	nitrate reductase activity
CG479_020525	COG0247	lactate metabolic process
CG479_020530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CG479_020545	COG2197	response regulator
CG479_020550	COG4585	Histidine kinase
CG479_020555	COG0842	Transport permease protein
CG479_020560	COG1131	(ABC) transporter
CG479_020565	COG0024	Methionine aminopeptidase
CG479_020570	COG2234	aminopeptidase activity
CG479_020585	COG4506	Protein conserved in bacteria
CG479_020590	COG1619	proteins homologs of microcin C7 resistance protein MccF
CG479_020610	COG0010	Belongs to the arginase family
CG479_020615	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CG479_020620	COG2814	Major facilitator Superfamily
CG479_020625	COG0789	Transcriptional regulator
CG479_020630	COG0584	glycerophosphoryl diester phosphodiesterase
CG479_020635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG479_020640	COG2801	Transposase and inactivated derivatives
CG479_020645	COG1404	Belongs to the peptidase S8 family
CG479_020665	COG1994	Peptidase M50
CG479_020675	COG1078	dGTPase activity
CG479_020680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG479_020685	COG1120	ATPase activity
CG479_020690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG479_020695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG479_020700	COG4844	belongs to the
CG479_020715	COG0280	phosphate acetyltransferase
CG479_020730	COG3773	Cell wall hydrolase
CG479_020740	COG2363	Small membrane protein
CG479_020750	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CG479_020755	COG2233	PERMEase
CG479_020760	COG0561	phosphatase activity
CG479_020765	COG2814	Major facilitator Superfamily
CG479_020770	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CG479_020775	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CG479_020780	COG1131	(ABC) transporter
CG479_020785	COG2755	lipolytic protein G-D-S-L family
CG479_020790	COG0460	homoserine dehydrogenase
CG479_020795	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CG479_020810	COG0351	phosphomethylpyrimidine kinase
CG479_020820	COG1966	Carbon starvation protein
CG479_020825	COG3279	Response regulator of the LytR AlgR family
CG479_020835	COG0477	Major facilitator Superfamily
CG479_020845	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CG479_020850	COG0438	transferase activity, transferring glycosyl groups
CG479_020865	COG0840	transmembrane signaling receptor activity
CG479_020890	COG1607	acyl-coa hydrolase
CG479_020895	COG1216	Glycosyl transferase, family 2
CG479_020910	COG0463	Glycosyl transferase, family 2
CG479_020925	COG0463	Glycosyl transferase, family 2
CG479_020930	COG0488	(ABC) transporter
CG479_020935	COG1309	transcriptional regulator
CG479_020940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CG479_020945	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CG479_020945	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CG479_020950	COG0628	permease
CG479_020955	COG1346	cytolysis
CG479_020965	COG3279	Response regulator of the LytR AlgR family
CG479_020970	COG3275	phosphorelay sensor kinase activity
CG479_020975	COG2814	Major facilitator Superfamily
CG479_020980	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
CG479_020985	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CG479_021000	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CG479_021005	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG479_021005	COG3711	transcriptional antiterminator
CG479_021105	COG0457	Tetratricopeptide repeat
CG479_021155	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CG479_021160	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CG479_021170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CG479_021175	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CG479_021180	COG4853	Protein conserved in bacteria
CG479_021190	COG5002	protein histidine kinase activity
CG479_021195	COG0745	RESPONSE REGULATOR receiver
CG479_021220	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CG479_021225	COG0305	Participates in initiation and elongation during chromosome replication
CG479_021230	COG0359	binds to the 23S rRNA
CG479_021235	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CG479_021240	COG4241	membrane
CG479_021245	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CG479_021250	COG0629	single-stranded DNA binding
CG479_021255	COG0360	Binds together with S18 to 16S ribosomal RNA
CG479_021260	COG0012	GTP binding
CG479_021265	COG4481	Protein conserved in bacteria
CG479_021270	COG0668	transmembrane transport
CG479_021280	COG1475	DNA binding
CG479_021285	COG1192	Involved in chromosome partitioning
CG479_021290	COG1475	DNA binding
CG479_021295	COG0357	Ribosomal RNA small subunit methyltransferase G
CG479_021300	COG0445	tRNA wobble uridine modification
CG479_021305	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CG479_021310	COG1847	R3H domain protein
CG479_021315	COG0706	membrane insertase activity
CG479_021320	COG0594	ribonuclease P activity
CG479_021370	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CG479_021425	COG1028	Short-chain dehydrogenase reductase Sdr
CG479_021445	COG0583	DNA-binding transcription factor activity
CG479_021470	COG4974	Belongs to the 'phage' integrase family
CG479_021505	COG4166	transmembrane transport
CG479_021515	COG0457	Tetratricopeptide repeat
CG479_021555	COG1192	Involved in chromosome partitioning
CG479_021705	COG0741	lytic transglycosylase activity
CG479_021705	COG0791	NLP P60 protein