locus-tag	class	description
CG476_000005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CG476_000010	COG0592	DNA-directed DNA polymerase activity
CG476_000015	COG2501	S4 domain
CG476_000020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CG476_000025	COG0187	DNA topoisomerase II activity
CG476_000030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CG476_000065	COG0517	IMP dehydrogenase activity
CG476_000065	COG0516	GMP reductase activity
CG476_000070	COG1686	Belongs to the peptidase S11 family
CG476_000075	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CG476_000080	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CG476_000085	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CG476_000100	COG1428	Deoxynucleoside kinase
CG476_000105	COG1428	Deoxynucleoside kinase
CG476_000110	COG1335	isochorismatase
CG476_000115	COG0590	tRNA wobble adenosine to inosine editing
CG476_000125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CG476_000130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CG476_000135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CG476_000180	COG1982	Orn Lys Arg decarboxylase major
CG476_000185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CG476_000190	COG0470	DNA polymerase III
CG476_000195	COG1774	PSP1 C-terminal conserved region
CG476_000200	COG4467	Involved in initiation control of chromosome replication
CG476_000205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CG476_000215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CG476_000220	COG2002	toxin-antitoxin pair type II binding
CG476_000230	COG0084	hydrolase, TatD family'
CG476_000240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CG476_000250	COG4466	Protein conserved in bacteria
CG476_000260	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CG476_000265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CG476_000270	COG0251	oxidation-reduction process
CG476_000275	COG2088	sporulation resulting in formation of a cellular spore
CG476_000280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CG476_000285	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CG476_000290	COG0193	aminoacyl-tRNA hydrolase activity
CG476_000300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CG476_000305	COG2002	toxin-antitoxin pair type II binding
CG476_000310	COG2244	polysaccharide biosynthetic process
CG476_000315	COG3956	TIGRFAM MazG family protein
CG476_000320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CG476_000340	COG1098	S1 RNA binding domain
CG476_000355	COG2208	phosphoserine phosphatase activity
CG476_000370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CG476_000375	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CG476_000380	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CG476_000385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CG476_000395	COG0512	Glutamine amidotransferase of anthranilate synthase
CG476_000400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CG476_000405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CG476_000410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CG476_000415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CG476_000420	COG1396	sequence-specific DNA binding
CG476_000425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CG476_000430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CG476_000465	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG476_000515	COG3880	PFAM UvrB UvrC protein
CG476_000520	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CG476_000525	COG0542	response to heat
CG476_000530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CG476_000540	COG4956	integral membrane protein (PIN domain superfamily)
CG476_000545	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CG476_000550	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CG476_000555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CG476_000560	COG1045	serine acetyltransferase
CG476_000565	COG0215	cysteine-tRNA ligase activity
CG476_000575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CG476_000580	COG3688	RNA-binding protein containing a PIN domain
CG476_000600	COG0250	Participates in transcription elongation, termination and antitermination
CG476_000610	COG0081	regulation of translation
CG476_000615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CG476_000620	COG0222	ribosome binding
CG476_000625	COG2813	Specifically methylates the guanine in position
CG476_000635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CG476_000640	COG1358	cellular component organization or biogenesis
CG476_000645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CG476_000650	COG0049	tRNA binding
CG476_000655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CG476_000660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CG476_000670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CG476_000675	COG0088	Forms part of the polypeptide exit tunnel
CG476_000680	COG0089	rRNA binding
CG476_000685	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CG476_000690	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CG476_000695	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CG476_000700	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CG476_000705	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CG476_000715	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CG476_000720	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CG476_000725	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CG476_000730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CG476_000740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CG476_000745	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CG476_000750	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CG476_000755	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CG476_000760	COG1841	ribosomal large subunit assembly
CG476_000765	COG0200	Binds to the 23S rRNA
CG476_000770	COG0201	protein transport
CG476_000775	COG0563	adenylate kinase activity
CG476_000780	COG0024	Methionine aminopeptidase
CG476_000790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CG476_000800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CG476_000805	COG0202	RNA polymerase activity
CG476_000820	COG1122	ATPase activity
CG476_000825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CG476_000835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CG476_000840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CG476_000850	COG0860	N-Acetylmuramoyl-L-alanine amidase
CG476_000855	COG0489	protein tyrosine kinase activity
CG476_000865	COG2194	sulfuric ester hydrolase activity
CG476_000870	COG0726	polysaccharide deacetylase
CG476_000900	COG4974	Belongs to the 'phage' integrase family
CG476_001055	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CG476_001065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CG476_001105	COG1396	sequence-specific DNA binding
CG476_001110	COG0602	queuosine metabolic process
CG476_001220	COG3681	Belongs to the UPF0597 family
CG476_001225	COG3681	Belongs to the UPF0597 family
CG476_001250	COG2814	Major facilitator Superfamily
CG476_001260	COG0601	transmembrane transport
CG476_001265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CG476_001270	COG0444	Belongs to the ABC transporter superfamily
CG476_001275	COG4608	Belongs to the ABC transporter superfamily
CG476_001280	COG4166	transmembrane transport
CG476_001290	COG2207	Transcriptional regulator
CG476_001300	COG1309	transcriptional regulator
CG476_001310	COG0656	L-ascorbic acid biosynthetic process
CG476_001315	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CG476_001325	COG4149	molybdate abc transporter
CG476_001330	COG0725	ABC transporter, periplasmic molybdate-binding protein
CG476_001335	COG1910	domain protein
CG476_001340	COG0204	Acyl-transferase
CG476_001345	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG476_001350	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CG476_001350	COG1648	precorrin-2 dehydrogenase activity
CG476_001360	COG1587	Uroporphyrinogen-III synthase
CG476_001360	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CG476_001365	COG2146	nitrite reductase [NAD(P)H] activity
CG476_001370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CG476_001400	COG4585	Histidine kinase
CG476_001405	COG2197	response regulator
CG476_001410	COG1131	(ABC) transporter
CG476_001415	COG0842	Transport permease protein
CG476_001415	COG1511	domain protein
CG476_001420	COG0842	Transport permease protein
CG476_001430	COG0747	negative chemotaxis
CG476_001435	COG0601	transmembrane transport
CG476_001440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CG476_001445	COG0444	Belongs to the ABC transporter superfamily
CG476_001450	COG4608	Belongs to the ABC transporter superfamily
CG476_001455	COG0561	phosphatase activity
CG476_001475	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CG476_001480	COG0179	Fumarylacetoacetate (FAA) hydrolase
CG476_001490	COG2814	Major facilitator Superfamily
CG476_001495	COG1181	Belongs to the D-alanine--D-alanine ligase family
CG476_001500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CG476_001510	COG0457	Tetratricopeptide repeat
CG476_001510	COG0705	Rhomboid family
CG476_001515	COG0736	holo-[acyl-carrier-protein] synthase activity
CG476_001520	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CG476_001530	COG0864	Transcriptional regulator
CG476_001535	COG2337	Toxic component of a toxin-antitoxin (TA) module
CG476_001540	COG2183	response to ionizing radiation
CG476_001550	COG3091	SprT-like family
CG476_001590	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG476_001640	COG0802	atpase or kinase
CG476_001645	COG1214	PFAM Peptidase M22, glycoprotease
CG476_001650	COG0456	acetyltransferase
CG476_001660	COG0488	(ABC) transporter
CG476_001665	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CG476_001675	COG1266	CAAX protease self-immunity
CG476_001680	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CG476_001685	COG0459	protein refolding
CG476_001690	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CG476_001690	COG0519	Catalyzes the synthesis of GMP from XMP
CG476_001695	COG2252	PERMEase
CG476_001705	COG5002	protein histidine kinase activity
CG476_001775	COG2205	protein histidine kinase activity
CG476_001780	COG0745	RESPONSE REGULATOR receiver
CG476_001800	COG0697	spore germination
CG476_001825	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CG476_001830	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CG476_001835	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CG476_001840	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CG476_001845	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CG476_001850	COG0047	phosphoribosylformylglycinamidine synthase activity
CG476_001855	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CG476_001860	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CG476_001865	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CG476_001870	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CG476_001875	COG0138	bifunctional purine biosynthesis protein purh
CG476_001880	COG0151	Belongs to the GarS family
CG476_001890	COG0583	DNA-binding transcription factor activity
CG476_001910	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CG476_001915	COG0210	DNA helicase
CG476_001920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CG476_001925	COG4851	CamS sex pheromone cAM373 precursor
CG476_001935	COG1012	belongs to the aldehyde dehydrogenase family
CG476_001940	COG1335	isochorismatase
CG476_001950	COG2011	ABC-type metal ion transport system permease component
CG476_001955	COG1464	Belongs to the NlpA lipoprotein family
CG476_001970	COG4682	membrane
CG476_001975	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CG476_001980	COG0154	amidase activity
CG476_001985	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CG476_001990	COG1597	lipid kinase activity
CG476_001995	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CG476_002000	COG0546	phosphoglycolate phosphatase activity
CG476_002005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CG476_002015	COG0531	amino acid
CG476_002020	COG1012	belongs to the aldehyde dehydrogenase family
CG476_002025	COG2076	Multidrug Resistance protein
CG476_002030	COG2309	aminopeptidase activity
CG476_002045	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG476_002050	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CG476_002055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CG476_002070	COG0450	alkyl hydroperoxide reductase
CG476_002095	COG0714	Associated with various cellular activities
CG476_002130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG476_002135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG476_002140	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG476_002145	COG0492	ferredoxin-NADP+ reductase activity
CG476_002155	COG0166	Belongs to the GPI family
CG476_002160	COG5002	protein histidine kinase activity
CG476_002185	COG3541	Predicted nucleotidyltransferase
CG476_002190	COG2814	Major facilitator Superfamily
CG476_002195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CG476_002195	COG0723	plastoquinol--plastocyanin reductase activity
CG476_002205	COG0765	amino acid transport
CG476_002210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG476_002215	COG1126	abc transporter atp-binding protein
CG476_002220	COG0840	transmembrane signaling receptor activity
CG476_002235	COG2235	arginine
CG476_002250	COG0549	Belongs to the carbamate kinase family
CG476_002265	COG0366	Alpha amylase catalytic
CG476_002270	COG1263	PTS System
CG476_002270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG476_002270	COG2190	(PTS) system
CG476_002290	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG476_002295	COG4605	iron ion homeostasis
CG476_002300	COG4604	ABC transporter, ATP-binding protein
CG476_002305	COG4607	ABC-type enterochelin transport system periplasmic component
CG476_002310	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CG476_002315	COG0352	thiamine-phosphate diphosphorylase activity
CG476_002320	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CG476_002340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG476_002350	COG1116	anion transmembrane transporter activity
CG476_002430	COG2963	transposase activity
CG476_002435	COG2801	Transposase and inactivated derivatives
CG476_002440	COG2270	Major facilitator Superfamily
CG476_002465	COG2310	stress, protein
CG476_002470	COG2310	stress, protein
CG476_002475	COG2310	stress, protein
CG476_002480	COG0861	Integral membrane protein TerC family
CG476_002490	COG3853	Toxic anion resistance protein (TelA)
CG476_002500	COG4840	Belongs to the UPF0435 family
CG476_002505	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CG476_002515	COG1295	ribonuclease BN
CG476_002520	COG2217	Heavy metal translocating P-type atpase
CG476_002525	COG0697	spore germination
CG476_002535	COG0681	Belongs to the peptidase S26 family
CG476_002545	COG0586	Pfam SNARE associated Golgi protein
CG476_002560	COG0387	Pfam Sodium calcium exchanger
CG476_002570	COG0535	radical SAM domain protein
CG476_002590	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CG476_002615	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CG476_002640	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CG476_002670	COG2066	Belongs to the glutaminase family
CG476_002675	COG1263	PTS System
CG476_002675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG476_002680	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG476_002690	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CG476_002690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CG476_002700	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CG476_002705	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CG476_002720	COG0402	S-adenosylhomocysteine deaminase activity
CG476_002725	COG2137	regulation of response to DNA damage stimulus
CG476_002750	COG1988	membrane-bound metal-dependent
CG476_002755	COG1194	a g-specific adenine glycosylase
CG476_002780	COG3557	Belongs to the UPF0374 family
CG476_002785	COG1132	(ABC) transporter
CG476_002790	COG4129	membrane
CG476_002795	COG0069	glutamate synthase activity
CG476_002795	COG0070	glutamate synthase
CG476_002795	COG0067	glutamate synthase
CG476_002800	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CG476_002805	COG4555	ABC transporter
CG476_002825	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CG476_002830	COG0735	belongs to the Fur family
CG476_002930	COG3157	Type VI secretion system effector, Hcp
CG476_002950	COG0457	Tetratricopeptide repeat
CG476_002955	COG0217	transcriptional regulatory protein
CG476_002960	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CG476_002965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CG476_002985	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CG476_002995	COG2766	serine protein kinase
CG476_003020	COG1280	lysine exporter protein (LysE YggA)
CG476_003060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CG476_003070	COG1585	Membrane protein implicated in regulation of membrane protease activity
CG476_003075	COG2268	Band 7 protein
CG476_003105	COG4990	cell redox homeostasis
CG476_003115	COG3290	protein histidine kinase activity
CG476_003120	COG4565	transcriptional regulatory protein
CG476_003125	COG3493	citrate carrier protein
CG476_003130	COG0281	malic enzyme
CG476_003145	COG5002	protein histidine kinase activity
CG476_003150	COG0745	RESPONSE REGULATOR receiver
CG476_003160	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CG476_003165	COG3383	formate dehydrogenase (NAD+) activity
CG476_003170	COG2427	Protein of unknown function (DUF1641)
CG476_003180	COG0840	transmembrane signaling receptor activity
CG476_003190	COG0531	amino acid
CG476_003205	COG0640	Transcriptional regulator
CG476_003210	COG2217	Heavy metal translocating P-type atpase
CG476_003215	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CG476_003225	COG3227	Zinc metalloprotease (Elastase)
CG476_003240	COG2217	Heavy metal translocating P-type atpase
CG476_003260	COG2720	vancomycin resistance protein
CG476_003265	COG1316	TRANSCRIPTIONal
CG476_003275	COG1253	flavin adenine dinucleotide binding
CG476_003280	COG1027	Aspartate ammonia-lyase
CG476_003285	COG1620	l-lactate permease
CG476_003305	COG3104	oligopeptide transport
CG476_003310	COG0156	8-amino-7-oxononanoate synthase activity
CG476_003315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CG476_003330	COG4548	von Willebrand factor, type A
CG476_003335	COG0714	Associated with various cellular activities
CG476_003340	COG0531	amino acid
CG476_003345	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG476_003350	COG1115	amino acid carrier protein
CG476_003360	COG1126	abc transporter atp-binding protein
CG476_003365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG476_003370	COG0765	amino acid transport
CG476_003375	COG0765	amino acid transport
CG476_003380	COG0833	amino acid
CG476_003390	COG5002	protein histidine kinase activity
CG476_003395	COG0745	RESPONSE REGULATOR receiver
CG476_003405	COG0659	secondary active sulfate transmembrane transporter activity
CG476_003410	COG0589	response to stress
CG476_003420	COG0747	negative chemotaxis
CG476_003430	COG0601	transmembrane transport
CG476_003435	COG4608	Belongs to the ABC transporter superfamily
CG476_003445	COG2271	Major facilitator Superfamily
CG476_003450	COG1846	Transcriptional regulator
CG476_003455	COG0477	Major facilitator Superfamily
CG476_003460	COG1609	Transcriptional regulator
CG476_003465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CG476_003470	COG1869	D-ribose catabolic process
CG476_003475	COG1129	ABC transporter
CG476_003480	COG1172	Belongs to the binding-protein-dependent transport system permease family
CG476_003485	COG1879	ABC-type sugar transport system periplasmic component
CG476_003490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CG476_003530	COG3568	Endonuclease Exonuclease Phosphatase
CG476_003555	COG0840	transmembrane signaling receptor activity
CG476_003560	COG3584	3D domain protein
CG476_003560	COG3583	domain protein
CG476_003565	COG1476	TRANSCRIPTIONal
CG476_003595	COG1114	Component of the transport system for branched-chain amino acids
CG476_003605	COG1113	amino acid transport
CG476_003610	COG2153	protein acetylation
CG476_003620	COG0569	domain protein
CG476_003620	COG0475	glutathione-regulated potassium exporter activity
CG476_003635	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CG476_003640	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CG476_003645	COG0833	amino acid
CG476_003650	COG4990	cell redox homeostasis
CG476_003665	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG476_003670	COG0697	spore germination
CG476_003675	COG0531	amino acid
CG476_003690	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CG476_003695	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CG476_003700	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CG476_003700	COG1918	ferrous iron import across plasma membrane
CG476_003705	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CG476_003710	COG0573	inorganic phosphate transmembrane transporter activity
CG476_003720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CG476_003760	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG476_003845	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CG476_003870	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CG476_003875	COG1116	anion transmembrane transporter activity
CG476_003880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG476_003885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CG476_003890	COG0352	thiamine-phosphate diphosphorylase activity
CG476_003895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CG476_003900	COG2104	thiamine diphosphate biosynthetic process
CG476_003905	COG2022	thiamine diphosphate biosynthetic process
CG476_003910	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG476_003915	COG0351	phosphomethylpyrimidine kinase
CG476_003945	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CG476_003950	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CG476_003955	COG2205	protein histidine kinase activity
CG476_003965	COG4974	Belongs to the 'phage' integrase family
CG476_003985	COG0735	belongs to the Fur family
CG476_004010	COG1846	Transcriptional regulator
CG476_004020	COG2252	PERMEase
CG476_004025	COG1028	Short-chain dehydrogenase reductase Sdr
CG476_004030	COG1376	ErfK ybiS ycfS ynhG family protein
CG476_004055	COG1316	TRANSCRIPTIONal
CG476_004085	COG0778	Nitroreductase
CG476_004095	COG2719	SpoVR family
CG476_004105	COG1316	TRANSCRIPTIONal
CG476_004110	COG1283	sodium-dependent phosphate transmembrane transporter activity
CG476_004125	COG0577	efflux transmembrane transporter activity
CG476_004130	COG1136	(ABC) transporter
CG476_004140	COG1114	Component of the transport system for branched-chain amino acids
CG476_004145	COG3546	catalase activity
CG476_004200	COG0475	glutathione-regulated potassium exporter activity
CG476_004205	COG1737	Transcriptional regulator
CG476_004215	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CG476_004220	COG1263	PTS System
CG476_004220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG476_004265	COG1522	sequence-specific DNA binding
CG476_004280	COG0531	amino acid
CG476_004290	COG1012	belongs to the aldehyde dehydrogenase family
CG476_004295	COG1132	(ABC) transporter
CG476_004300	COG1132	(ABC) transporter
CG476_004310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG476_004315	COG0765	amino acid transport
CG476_004320	COG1126	abc transporter atp-binding protein
CG476_004335	COG0189	ligase activity
CG476_004340	COG4399	Belongs to the UPF0754 family
CG476_004345	COG3679	Belongs to the UPF0342 family
CG476_004350	COG4585	Histidine kinase
CG476_004355	COG2197	response regulator
CG476_004415	COG2094	Belongs to the DNA glycosylase MPG family
CG476_004420	COG0561	phosphatase activity
CG476_004430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CG476_004435	COG0318	PFAM AMP-dependent synthetase and ligase
CG476_004460	COG2244	polysaccharide biosynthetic process
CG476_004470	COG0860	N-Acetylmuramoyl-L-alanine amidase
CG476_004490	COG1696	Membrane protein involved in D-alanine export
CG476_004505	COG1024	Enoyl-CoA hydratase
CG476_004520	COG1363	Peptidase, m42
CG476_004535	COG2239	Acts as a magnesium transporter
CG476_004540	COG0772	Belongs to the SEDS family
CG476_004545	COG1115	amino acid carrier protein
CG476_004670	COG1476	TRANSCRIPTIONal
CG476_004715	COG1131	(ABC) transporter
CG476_004760	COG0494	nUDIX hydrolase
CG476_004775	COG1061	Type III restriction enzyme res subunit
CG476_004790	COG4638	Rieske (2fe-2S)
CG476_004795	COG1012	belongs to the aldehyde dehydrogenase family
CG476_004800	COG0473	3-isopropylmalate dehydrogenase activity
CG476_004810	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG476_004820	COG1064	alcohol dehydrogenase
CG476_004835	COG3246	L-lysine catabolic process to acetate
CG476_004870	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CG476_004880	COG4641	Protein conserved in bacteria
CG476_004895	COG3711	transcriptional antiterminator
CG476_004900	COG2190	(PTS) system
CG476_004900	COG1263	PTS System
CG476_004900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG476_004905	COG2723	6-phospho-beta-galactosidase activity
CG476_004915	COG2376	Dihydroxyacetone kinase
CG476_004920	COG0393	Putative heavy-metal-binding
CG476_004950	COG0420	3'-5' exonuclease activity
CG476_004955	COG4717	serine-type aminopeptidase activity
CG476_004960	COG3481	metal-dependent phosphohydrolase, HD sub domain
CG476_004975	COG0577	efflux transmembrane transporter activity
CG476_004980	COG1136	(ABC) transporter
CG476_004985	COG5002	protein histidine kinase activity
CG476_004990	COG0745	RESPONSE REGULATOR receiver
CG476_005000	COG1316	TRANSCRIPTIONal
CG476_005015	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CG476_005020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CG476_005025	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CG476_005030	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CG476_005050	COG1846	Transcriptional regulator
CG476_005055	COG4980	gas vesicle protein
CG476_005065	COG0537	adenosine 5'-monophosphoramidase activity
CG476_005070	COG1131	(ABC) transporter
CG476_005075	COG4473	ABC transporter
CG476_005095	COG3402	PFAM membrane-flanked domain
CG476_005105	COG2329	Antibiotic biosynthesis monooxygenase
CG476_005110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG476_005115	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CG476_005155	COG1309	transcriptional regulator
CG476_005165	COG1216	Glycosyl transferase, family 2
CG476_005165	COG0438	transferase activity, transferring glycosyl groups
CG476_005175	COG1609	Transcriptional regulator
CG476_005185	COG1234	tRNA 3'-trailer cleavage
CG476_005190	COG0095	Lipoate-protein ligase
CG476_005200	COG0318	PFAM AMP-dependent synthetase and ligase
CG476_005215	COG2205	protein histidine kinase activity
CG476_005220	COG0745	RESPONSE REGULATOR receiver
CG476_005240	COG0501	Belongs to the peptidase M48B family
CG476_005245	COG0840	transmembrane signaling receptor activity
CG476_005250	COG0697	spore germination
CG476_005265	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CG476_005270	COG2224	Isocitrate lyase
CG476_005275	COG1278	Cold shock
CG476_005280	COG4903	ComK protein
CG476_005285	COG0398	Pfam SNARE associated Golgi protein
CG476_005295	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CG476_005300	COG1074	ATP-dependent DNA helicase activity
CG476_005340	COG0179	Fumarylacetoacetate (FAA) hydrolase
CG476_005360	COG0367	asparagine synthase
CG476_005370	COG0753	catalase activity
CG476_005380	COG0366	Alpha amylase catalytic
CG476_005380	COG1874	Beta-galactosidase
CG476_005385	COG1666	GTP binding
CG476_005390	COG2996	Protein conserved in bacteria
CG476_005405	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG476_005420	COG0561	phosphatase activity
CG476_005445	COG2267	carboxylic ester hydrolase activity
CG476_005460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CG476_005465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CG476_005470	COG5504	Zn-dependent protease
CG476_005480	COG0180	Tryptophanyl-tRNA synthetase
CG476_005495	COG4166	transmembrane transport
CG476_005500	COG0601	transmembrane transport
CG476_005505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CG476_005510	COG0444	Belongs to the ABC transporter superfamily
CG476_005515	COG4608	Belongs to the ABC transporter superfamily
CG476_005520	COG0534	Mate efflux family protein
CG476_005525	COG4166	transmembrane transport
CG476_005545	COG1393	Belongs to the ArsC family
CG476_005550	COG0861	Integral membrane protein TerC family
CG476_005570	COG1164	Oligoendopeptidase f
CG476_005585	COG2346	COG2346, Truncated hemoglobins
CG476_005590	COG4116	CYTH
CG476_005600	COG2357	RelA SpoT domain protein
CG476_005610	COG0564	pseudouridine synthase activity
CG476_005620	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CG476_005625	COG0772	Belongs to the SEDS family
CG476_005670	COG1216	Glycosyl transferase, family 2
CG476_005690	COG0463	Glycosyl transferase, family 2
CG476_005690	COG0457	Tetratricopeptide repeat
CG476_005710	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CG476_005725	COG1091	dTDP-4-dehydrorhamnose reductase activity
CG476_005750	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CG476_005755	COG2382	esterase
CG476_005770	COG5492	domain, Protein
CG476_005775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG476_005790	COG1620	l-lactate permease
CG476_005795	COG5634	Uncharacterized conserved protein (DUF2278)
CG476_005835	COG0508	dehydrogenase complex catalyzes the overall conversion of
CG476_005840	COG0567	Dehydrogenase, E1 component
CG476_005850	COG0583	DNA-binding transcription factor activity
CG476_005855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CG476_005860	COG1012	belongs to the aldehyde dehydrogenase family
CG476_005875	COG0196	riboflavin kinase activity
CG476_005880	COG3162	membrane
CG476_005885	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG476_005890	COG0179	Fumarylacetoacetate (FAA) hydrolase
CG476_005905	COG0457	Tetratricopeptide repeat
CG476_005970	COG0673	inositol 2-dehydrogenase activity
CG476_006000	COG0457	Tetratricopeptide repeat
CG476_006005	COG0582	viral genome integration into host DNA
CG476_006055	COG0582	viral genome integration into host DNA
CG476_006080	COG1686	Belongs to the peptidase S11 family
CG476_006085	COG0681	Belongs to the peptidase S26 family
CG476_006120	COG1012	belongs to the aldehyde dehydrogenase family
CG476_006130	COG1176	ABC-type spermidine putrescine transport system, permease component I
CG476_006135	COG1177	transmembrane transport
CG476_006140	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CG476_006145	COG0671	phosphoesterase, PA-phosphatase related
CG476_006150	COG2409	Drug exporters of the RND superfamily
CG476_006160	COG0564	pseudouridine synthase activity
CG476_006170	COG2340	Cysteine-rich secretory protein family
CG476_006175	COG0247	lactate metabolic process
CG476_006180	COG0277	FAD linked oxidase domain protein
CG476_006185	COG3835	regulator
CG476_006195	COG0745	RESPONSE REGULATOR receiver
CG476_006200	COG5002	protein histidine kinase activity
CG476_006205	COG2186	Transcriptional regulator
CG476_006210	COG0247	lactate metabolic process
CG476_006215	COG1139	Iron-sulfur cluster binding protein
CG476_006220	COG1556	Lactate utilization protein
CG476_006225	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CG476_006230	COG0584	glycerophosphoryl diester phosphodiesterase
CG476_006245	COG2267	carboxylic ester hydrolase activity
CG476_006250	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG476_006275	COG2116	formate transmembrane transporter activity
CG476_006280	COG0861	Integral membrane protein TerC family
CG476_006285	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CG476_006295	COG2030	dehydratase
CG476_006315	COG1028	Short-chain dehydrogenase reductase Sdr
CG476_006320	COG3243	poly(R)-hydroxyalkanoic acid synthase
CG476_006325	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CG476_006340	COG1840	ABC-type Fe3 transport system, periplasmic component
CG476_006345	COG3842	ATPase activity
CG476_006355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CG476_006360	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CG476_006365	COG1349	DNA-binding transcription factor activity
CG476_006370	COG0235	Class ii aldolase
CG476_006380	COG2861	carbohydrate metabolic process
CG476_006390	COG3852	Histidine kinase
CG476_006395	COG1846	Transcriptional regulator
CG476_006415	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CG476_006420	COG0720	synthase
CG476_006430	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CG476_006435	COG4873	Protein conserved in bacteria
CG476_006445	COG0456	acetyltransferase
CG476_006465	COG1780	Probably involved in ribonucleotide reductase function
CG476_006480	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CG476_006485	COG1725	Transcriptional regulator
CG476_006490	COG1131	(ABC) transporter
CG476_006500	COG1131	(ABC) transporter
CG476_006505	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CG476_006520	COG1522	sequence-specific DNA binding
CG476_006535	COG1619	proteins homologs of microcin C7 resistance protein MccF
CG476_006540	COG2070	2-Nitropropane dioxygenase
CG476_006545	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CG476_006555	COG1696	Membrane protein involved in D-alanine export
CG476_006560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CG476_006575	COG0716	FMN binding
CG476_006600	COG1368	sulfuric ester hydrolase activity
CG476_006610	COG3173	Aminoglycoside phosphotransferase
CG476_006625	COG5609	conserved protein (DUF2294)
CG476_006630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CG476_006635	COG3002	Belongs to the UPF0753 family
CG476_006640	COG0288	reversible hydration of carbon dioxide
CG476_006645	COG0534	Mate efflux family protein
CG476_006660	COG1846	Transcriptional regulator
CG476_006670	COG1301	dicarboxylic acid transport
CG476_006675	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CG476_006685	COG3874	Sporulation protein YtfJ
CG476_006710	COG0028	Belongs to the TPP enzyme family
CG476_006715	COG0440	acetolactate synthase activity
CG476_006720	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CG476_006725	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CG476_006735	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CG476_006740	COG0066	3-isopropylmalate dehydratase activity
CG476_006750	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CG476_006760	COG0131	Imidazoleglycerol-phosphate dehydratase
CG476_006765	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CG476_006770	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CG476_006775	COG0107	imidazoleglycerol-phosphate synthase activity
CG476_006780	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CG476_006785	COG0140	phosphoribosyl-ATP diphosphatase activity
CG476_006800	COG1183	phosphatidylcholine synthase activity
CG476_006805	COG1368	sulfuric ester hydrolase activity
CG476_006815	COG0019	diaminopimelate decarboxylase activity
CG476_006825	COG0175	sulfate reduction
CG476_006830	COG2046	Belongs to the sulfate adenylyltransferase family
CG476_006835	COG0529	Catalyzes the synthesis of activated sulfate
CG476_006840	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CG476_006860	COG1648	precorrin-2 dehydrogenase activity
CG476_006860	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CG476_006865	COG0733	neurotransmitter:sodium symporter activity
CG476_006880	COG3557	Belongs to the UPF0374 family
CG476_006885	COG1757	Na H antiporter
CG476_006900	COG4758	membrane
CG476_006905	COG4585	Histidine kinase
CG476_006910	COG2197	response regulator
CG476_006915	COG1114	Component of the transport system for branched-chain amino acids
CG476_006920	COG1525	nuclease
CG476_006920	COG0737	Belongs to the 5'-nucleotidase family
CG476_006920	COG4085	toxin activity
CG476_006950	COG3711	transcriptional antiterminator
CG476_006960	COG2723	6-phospho-beta-galactosidase activity
CG476_006975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG476_006975	COG3711	transcriptional antiterminator
CG476_006980	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG476_006980	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG476_006980	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG476_006985	COG1482	cell wall glycoprotein biosynthetic process
CG476_006995	COG2801	Transposase and inactivated derivatives
CG476_007015	COG0730	response to heat
CG476_007020	COG0306	phosphate transporter
CG476_007025	COG1392	Phosphate transport regulator
CG476_007030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG476_007040	COG3852	Histidine kinase
CG476_007045	COG1801	Protein of unknown function DUF72
CG476_007055	COG0582	viral genome integration into host DNA
CG476_007060	COG5002	protein histidine kinase activity
CG476_007065	COG0813	purine-nucleoside phosphorylase activity
CG476_007075	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CG476_007075	COG0392	lysyltransferase activity
CG476_007090	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CG476_007095	COG1686	Belongs to the peptidase S11 family
CG476_007100	COG2715	membrane protein required for spore maturation
CG476_007105	COG0700	Nucleoside recognition
CG476_007110	COG1187	pseudouridine synthase activity
CG476_007120	COG1333	cytochrome c biogenesis protein
CG476_007125	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CG476_007130	COG0745	RESPONSE REGULATOR receiver
CG476_007135	COG5002	protein histidine kinase activity
CG476_007140	COG2096	Adenosyltransferase
CG476_007160	COG1141	Ferredoxin
CG476_007170	COG0514	ATP-dependent DNA helicase (RecQ)
CG476_007175	COG1266	CAAX protease self-immunity
CG476_007185	COG1408	metallophosphoesterase
CG476_007200	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CG476_007215	COG0492	ferredoxin-NADP+ reductase activity
CG476_007230	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CG476_007240	COG1304	FMN binding
CG476_007265	COG1160	GTP binding
CG476_007270	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CG476_007290	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CG476_007300	COG0302	gtp cyclohydrolase
CG476_007305	COG0142	geranyltranstransferase activity
CG476_007310	COG2226	methyltransferase
CG476_007315	COG0142	geranyltranstransferase activity
CG476_007320	COG0105	UTP biosynthetic process
CG476_007325	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CG476_007330	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CG476_007335	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CG476_007340	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CG476_007345	COG0457	Tetratricopeptide repeat
CG476_007350	COG5582	Belongs to the UPF0302 family
CG476_007365	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CG476_007375	COG4347	Protein of unknown function (DUF1405)
CG476_007390	COG2738	Putative neutral zinc metallopeptidase
CG476_007400	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG476_007405	COG1694	Mazg nucleotide pyrophosphohydrolase
CG476_007410	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CG476_007415	COG1803	Methylglyoxal synthase
CG476_007420	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CG476_007425	COG0438	transferase activity, transferring glycosyl groups
CG476_007430	COG0617	tRNA 3'-terminal CCA addition
CG476_007445	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CG476_007450	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CG476_007455	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CG476_007460	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CG476_007460	COG1199	ATP-dependent helicase activity
CG476_007480	COG3935	DnaD domain protein
CG476_007485	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CG476_007495	COG4499	WXG100 protein secretion system (Wss), protein YukC
CG476_007495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG476_007500	COG3331	DNA recombination
CG476_007535	COG4474	Belongs to the UPF0398 family
CG476_007540	COG3599	regulation of cell shape
CG476_007550	COG0116	Belongs to the methyltransferase superfamily
CG476_007560	COG1199	ATP-dependent helicase activity
CG476_007565	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CG476_007570	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CG476_007575	COG2233	PERMEase
CG476_007580	COG2311	Membrane
CG476_007585	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CG476_007595	COG0456	acetyltransferase
CG476_007635	COG3766	membrane
CG476_007640	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CG476_007645	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CG476_007650	COG1733	regulation of RNA biosynthetic process
CG476_007670	COG0328	RNA-DNA hybrid ribonuclease activity
CG476_007700	COG1278	Cold shock
CG476_007710	COG3162	membrane
CG476_007715	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG476_007720	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CG476_007725	COG0475	glutathione-regulated potassium exporter activity
CG476_007755	COG2323	membrane
CG476_007760	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CG476_007785	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CG476_007795	COG2201	protein-glutamate methylesterase activity
CG476_007800	COG0643	Histidine kinase
CG476_007800	COG2198	Histidine kinase
CG476_007805	COG1776	CheC inhibitor of MCP methylation
CG476_007805	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG476_007820	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CG476_007840	COG1256	bacterial-type flagellum assembly
CG476_007845	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CG476_007850	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CG476_007865	COG1815	bacterial-type flagellum-dependent cell motility
CG476_007870	COG1558	bacterial-type flagellum-dependent cell motility
CG476_007875	COG1677	Flagellar hook-basal body complex protein FliE
CG476_007885	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG476_007895	COG1157	protein secretion by the type III secretion system
CG476_007930	COG0784	Response regulator, receiver
CG476_007930	COG0835	chemotaxis
CG476_007940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CG476_007945	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CG476_007950	COG0741	lytic transglycosylase activity
CG476_007960	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG476_007965	COG1776	CheC inhibitor of MCP methylation
CG476_007965	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG476_007975	COG1338	Plays a role in the flagellum-specific transport system
CG476_007980	COG1987	bacterial-type flagellum assembly
CG476_007990	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CG476_007995	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CG476_008000	COG1419	protein localization to endoplasmic reticulum
CG476_008005	COG4786	Flagellar basal body rod
CG476_008010	COG1136	(ABC) transporter
CG476_008010	COG0577	efflux transmembrane transporter activity
CG476_008060	COG2814	Major facilitator Superfamily
CG476_008070	COG1028	Short-chain dehydrogenase reductase Sdr
CG476_008105	COG0367	asparagine synthase
CG476_008125	COG1802	Transcriptional regulator
CG476_008130	COG0697	spore germination
CG476_008140	COG1757	Na H antiporter
CG476_008150	COG0114	fumarate hydratase activity
CG476_008175	COG0534	Mate efflux family protein
CG476_008180	COG3340	Belongs to the peptidase S51 family
CG476_008185	COG2733	membrane
CG476_008195	COG1280	lysine exporter protein (LysE YggA)
CG476_008200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CG476_008215	COG2502	aspartate--ammonia ligase
CG476_008225	COG0109	protoheme IX farnesyltransferase activity
CG476_008255	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CG476_008265	COG4166	transmembrane transport
CG476_008270	COG2223	nitrite transmembrane transporter activity
CG476_008275	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CG476_008280	COG2244	polysaccharide biosynthetic process
CG476_008285	COG0733	neurotransmitter:sodium symporter activity
CG476_008290	COG5566	PFAM Mor transcription activator
CG476_008305	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CG476_008310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CG476_008325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CG476_008355	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG476_008360	COG2814	Major facilitator Superfamily
CG476_008365	COG3384	dioxygenase
CG476_008385	COG0402	S-adenosylhomocysteine deaminase activity
CG476_008390	COG4166	transmembrane transport
CG476_008400	COG1914	H( )-stimulated, divalent metal cation uptake system
CG476_008415	COG0083	homoserine kinase activity
CG476_008425	COG2390	Transcriptional regulator
CG476_008430	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CG476_008455	COG1510	regulation of RNA biosynthetic process
CG476_008465	COG1454	alcohol dehydrogenase
CG476_008480	COG1012	belongs to the aldehyde dehydrogenase family
CG476_008495	COG0628	permease
CG476_008500	COG0039	L-malate dehydrogenase activity
CG476_008505	COG0523	cobalamin synthesis protein
CG476_008530	COG1686	Belongs to the peptidase S11 family
CG476_008545	COG0791	NLP P60 protein
CG476_008545	COG1388	LysM domain
CG476_008550	COG0300	oxidoreductase activity
CG476_008560	COG0460	homoserine dehydrogenase
CG476_008570	COG0083	homoserine kinase activity
CG476_008575	COG1316	TRANSCRIPTIONal
CG476_008580	COG0726	polysaccharide deacetylase
CG476_008590	COG1285	pathogenesis
CG476_008595	COG1247	-acetyltransferase
CG476_008610	COG1752	Esterase of the alpha-beta hydrolase superfamily
CG476_008630	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CG476_008635	COG0577	efflux transmembrane transporter activity
CG476_008640	COG2409	Drug exporters of the RND superfamily
CG476_008645	COG1404	Belongs to the peptidase S8 family
CG476_008660	COG0840	transmembrane signaling receptor activity
CG476_008675	COG3949	Membrane
CG476_008680	COG0783	Belongs to the Dps family
CG476_008700	COG0523	cobalamin synthesis protein
CG476_008710	COG0803	Belongs to the bacterial solute-binding protein 9 family
CG476_008725	COG1902	pentaerythritol trinitrate reductase activity
CG476_008730	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CG476_008740	COG4166	transmembrane transport
CG476_008745	COG0346	lactoylglutathione lyase activity
CG476_008755	COG5337	Spore coat protein CotH
CG476_008760	COG1051	belongs to the nudix hydrolase family
CG476_008765	COG0586	Pfam SNARE associated Golgi protein
CG476_008770	COG2244	polysaccharide biosynthetic process
CG476_008780	COG0701	Predicted permease
CG476_008785	COG3689	TIGRFAM TIGR03943 family protein
CG476_008790	COG1607	acyl-coa hydrolase
CG476_008800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CG476_008810	COG1028	Short-chain dehydrogenase reductase Sdr
CG476_008820	COG2839	Protein conserved in bacteria
CG476_008825	COG1253	flavin adenine dinucleotide binding
CG476_008865	COG0860	N-Acetylmuramoyl-L-alanine amidase
CG476_008875	COG1876	peptidase activity
CG476_008925	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CG476_008930	COG1819	glycosyl
CG476_008935	COG1819	glycosyl
CG476_008940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG476_008990	COG4499	WXG100 protein secretion system (Wss), protein YukC
CG476_009045	COG3874	Sporulation protein YtfJ
CG476_009070	COG2226	methyltransferase
CG476_009095	COG0386	Belongs to the glutathione peroxidase family
CG476_009130	COG0640	Transcriptional regulator
CG476_009135	COG0798	PFAM Bile acid sodium symporter
CG476_009140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CG476_009185	COG1418	mRNA catabolic process
CG476_009190	COG0488	(ABC) transporter
CG476_009200	COG0629	single-stranded DNA binding
CG476_009205	COG1413	lyase activity
CG476_009220	COG2136	Putative SAM-dependent methyltransferase
CG476_009220	COG2521	methyltransferase
CG476_009225	COG0018	arginyl-trna synthetase
CG476_009235	COG0733	neurotransmitter:sodium symporter activity
CG476_009260	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG476_009265	COG0477	Major facilitator Superfamily
CG476_009285	COG2610	gluconate transmembrane transporter activity
CG476_009295	COG0456	acetyltransferase
CG476_009300	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CG476_009310	COG1131	(ABC) transporter
CG476_009315	COG4473	ABC transporter
CG476_009330	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG476_009335	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CG476_009345	COG0768	penicillin binding
CG476_009355	COG0204	Acyl-transferase
CG476_009360	COG1272	protein, Hemolysin III
CG476_009365	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CG476_009370	COG0805	protein transport
CG476_009380	COG1307	EDD domain protein, DegV family
CG476_009390	COG1999	signal sequence binding
CG476_009395	COG0071	Belongs to the small heat shock protein (HSP20) family
CG476_009400	COG0367	asparagine synthase
CG476_009415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CG476_009435	COG0071	Belongs to the small heat shock protein (HSP20) family
CG476_009445	COG1737	Transcriptional regulator
CG476_009450	COG1070	Carbohydrate kinase
CG476_009460	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CG476_009515	COG1151	hydroxylamine reductase activity
CG476_009525	COG1253	flavin adenine dinucleotide binding
CG476_009530	COG5506	Protein of unknown function (DUF1694)
CG476_009550	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CG476_009555	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CG476_009560	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CG476_009565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CG476_009575	COG3829	transcription factor binding
CG476_009585	COG1509	lysine 2,3-aminomutase activity
CG476_009595	COG4479	Belongs to the UPF0346 family
CG476_009620	COG1357	PFAM Pentapeptide repeats (8 copies)
CG476_009620	COG0515	serine threonine protein kinase
CG476_009625	COG0671	phosphoesterase, PA-phosphatase related
CG476_009630	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CG476_009635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG476_009680	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CG476_009690	COG0726	polysaccharide deacetylase
CG476_009695	COG1408	metallophosphoesterase
CG476_009700	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CG476_009705	COG2323	membrane
CG476_009710	COG0671	phosphoesterase, PA-phosphatase related
CG476_009720	COG1280	lysine exporter protein (LysE YggA)
CG476_009725	COG3403	YqcI/YcgG family
CG476_009755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG476_009755	COG4499	WXG100 protein secretion system (Wss), protein YukC
CG476_009765	COG0372	Belongs to the citrate synthase family
CG476_009770	COG2079	MmgE PrpD family protein
CG476_009775	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CG476_009780	COG1960	acyl-CoA dehydrogenase activity
CG476_009785	COG2084	Dehydrogenase
CG476_009790	COG1012	belongs to the aldehyde dehydrogenase family
CG476_009800	COG1280	lysine exporter protein (LysE YggA)
CG476_009820	COG0420	3'-5' exonuclease activity
CG476_009825	COG0419	ATPase involved in DNA repair
CG476_009830	COG3104	oligopeptide transport
CG476_009860	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CG476_009865	COG1131	(ABC) transporter
CG476_009885	COG1131	(ABC) transporter
CG476_009890	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CG476_009910	COG1942	4-Oxalocrotonate Tautomerase
CG476_009945	COG0457	Tetratricopeptide repeat
CG476_009980	COG1028	Short-chain dehydrogenase reductase Sdr
CG476_009985	COG1169	isochorismate synthase
CG476_009990	COG1021	2,3-dihydroxybenzoate-AMP ligase
CG476_009995	COG3433	isochorismatase activity
CG476_009995	COG1535	isochorismatase
CG476_010000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CG476_010005	COG3251	PFAM MbtH domain protein
CG476_010010	COG2814	Major facilitator Superfamily
CG476_010025	COG0776	regulation of translation
CG476_010040	COG2329	Antibiotic biosynthesis monooxygenase
CG476_010045	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CG476_010080	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CG476_010090	COG0667	Aldo Keto reductase
CG476_010110	COG0010	Belongs to the arginase family
CG476_010120	COG1132	(ABC) transporter
CG476_010125	COG1132	(ABC) transporter
CG476_010130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CG476_010155	COG1649	PFAM Uncharacterised BCR, COG1649
CG476_010175	COG2971	BadF BadG BcrA BcrD
CG476_010195	COG0588	phosphoglycerate mutase activity
CG476_010225	COG2195	Cleaves the N-terminal amino acid of tripeptides
CG476_010235	COG1960	acyl-CoA dehydrogenase activity
CG476_010240	COG0439	Biotin carboxylase
CG476_010245	COG0511	ligase activity, forming carbon-carbon bonds
CG476_010250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CG476_010255	COG1024	Enoyl-CoA hydratase
CG476_010260	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CG476_010265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CG476_010275	COG1216	Glycosyl transferase, family 2
CG476_010280	COG0640	Transcriptional regulator
CG476_010290	COG1686	Belongs to the peptidase S11 family
CG476_010295	COG5002	protein histidine kinase activity
CG476_010325	COG0789	Transcriptional regulator
CG476_010345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CG476_010355	COG1028	Short-chain dehydrogenase reductase Sdr
CG476_010375	COG0475	glutathione-regulated potassium exporter activity
CG476_010395	COG1309	transcriptional regulator
CG476_010405	COG1028	Short-chain dehydrogenase reductase Sdr
CG476_010410	COG2002	toxin-antitoxin pair type II binding
CG476_010415	COG3773	Cell wall hydrolase
CG476_010415	COG3409	Peptidoglycan-binding domain 1 protein
CG476_010430	COG0693	protein deglycase activity
CG476_010435	COG0201	protein transport
CG476_010455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CG476_010460	COG0322	excinuclease ABC activity
CG476_010475	COG4667	esterase of the alpha-beta hydrolase superfamily
CG476_010495	COG1051	belongs to the nudix hydrolase family
CG476_010545	COG2223	nitrite transmembrane transporter activity
CG476_010595	COG1216	Glycosyl transferase, family 2
CG476_010610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG476_010615	COG1279	arginine transmembrane transporter activity
CG476_010655	COG1794	racemase activity, acting on amino acids and derivatives
CG476_010665	COG2828	Protein conserved in bacteria
CG476_010670	COG5002	protein histidine kinase activity
CG476_010675	COG0561	phosphatase activity
CG476_010695	COG2124	cytochrome p450
CG476_010730	COG0457	Tetratricopeptide repeat
CG476_010740	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CG476_010770	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CG476_010775	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG476_010785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG476_010795	COG2959	enzyme of heme biosynthesis
CG476_010800	COG3409	Peptidoglycan-binding domain 1 protein
CG476_010800	COG3773	Cell wall hydrolase
CG476_010825	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CG476_010830	COG3844	kynureninase activity
CG476_010840	COG1028	Short-chain dehydrogenase reductase Sdr
CG476_010850	COG4176	ABC-type proline glycine betaine transport system permease component
CG476_010855	COG4175	Glycine betaine
CG476_010855	COG0517	IMP dehydrogenase activity
CG476_010885	COG2153	protein acetylation
CG476_010915	COG0514	ATP-dependent DNA helicase (RecQ)
CG476_010935	COG4637	Psort location Cytoplasmic, score
CG476_010940	COG1227	inorganic diphosphatase activity
CG476_010950	COG3397	chitin binding
CG476_010990	COG4166	transmembrane transport
CG476_011000	COG4948	Mandelate Racemase Muconate Lactonizing
CG476_011080	COG1307	EDD domain protein, DegV family
CG476_011130	COG5444	nuclease activity
CG476_011240	COG5444	nuclease activity
CG476_011260	COG2261	transglycosylase associated protein
CG476_011265	COG0675	Transposase, IS605 OrfB family
CG476_011290	COG0436	Aminotransferase
CG476_011305	COG3973	AAA domain
CG476_011310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG476_011335	COG0628	permease
CG476_011350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CG476_011355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG476_011360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CG476_011375	COG2746	aminoglycoside 3-N-acetyltransferase activity
CG476_011390	COG0456	acetyltransferase
CG476_011390	COG0454	-acetyltransferase
CG476_011400	COG0726	polysaccharide deacetylase
CG476_011405	COG3037	sugar-specific permease SgaT UlaA
CG476_011415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG476_011420	COG1368	sulfuric ester hydrolase activity
CG476_011425	COG0488	(ABC) transporter
CG476_011430	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CG476_011430	COG1605	Chorismate mutase
CG476_011450	COG0346	lactoylglutathione lyase activity
CG476_011460	COG3547	Transposase (IS116 IS110 IS902 family)
CG476_011465	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CG476_011505	COG2329	Antibiotic biosynthesis monooxygenase
CG476_011520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG476_011545	COG0494	nUDIX hydrolase
CG476_011560	COG0456	acetyltransferase
CG476_011565	COG0477	Major facilitator Superfamily
CG476_011580	COG0697	spore germination
CG476_011585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG476_011595	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CG476_011610	COG0730	response to heat
CG476_011620	COG0833	amino acid
CG476_011645	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CG476_011660	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CG476_011665	COG1984	allophanate hydrolase subunit 2
CG476_011670	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CG476_011675	COG1414	Transcriptional regulator
CG476_011690	COG1960	acyl-CoA dehydrogenase activity
CG476_011720	COG0346	lactoylglutathione lyase activity
CG476_011730	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CG476_011735	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CG476_011740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CG476_011745	COG0438	transferase activity, transferring glycosyl groups
CG476_011760	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG476_011765	COG0438	transferase activity, transferring glycosyl groups
CG476_011770	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG476_011780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CG476_011800	COG4851	CamS sex pheromone cAM373 precursor
CG476_011920	COG0477	Major facilitator Superfamily
CG476_011935	COG1846	Transcriptional regulator
CG476_011940	COG2814	Major facilitator Superfamily
CG476_011950	COG2031	fatty acid transporter
CG476_011985	COG1122	ATPase activity
CG476_012010	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CG476_012025	COG1131	(ABC) transporter
CG476_012085	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CG476_012090	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG476_012095	COG0579	oxidoreductase
CG476_012100	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CG476_012110	COG1253	flavin adenine dinucleotide binding
CG476_012115	COG0789	Transcriptional regulator
CG476_012120	COG3813	Protein conserved in bacteria
CG476_012200	COG0582	viral genome integration into host DNA
CG476_012240	COG4591	ABC-type transport system involved in lipoprotein release permease component
CG476_012245	COG0577	efflux transmembrane transporter activity
CG476_012245	COG1136	(ABC) transporter
CG476_012310	COG2072	flavoprotein involved in K transport
CG476_012335	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CG476_012340	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CG476_012355	COG1193	negative regulation of DNA recombination
CG476_012360	COG2162	N-hydroxyarylamine O-acetyltransferase activity
CG476_012365	COG1164	Oligoendopeptidase f
CG476_012385	COG0584	glycerophosphoryl diester phosphodiesterase
CG476_012390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG476_012420	COG3397	chitin binding
CG476_012430	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CG476_012435	COG0277	FAD linked oxidase domain protein
CG476_012440	COG1285	pathogenesis
CG476_012445	COG2720	vancomycin resistance protein
CG476_012645	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CG476_012750	COG1484	DNA-dependent DNA replication
CG476_012800	COG0582	viral genome integration into host DNA
CG476_012825	COG1278	Cold shock
CG476_012835	COG1028	Short-chain dehydrogenase reductase Sdr
CG476_012840	COG0165	Argininosuccinate lyase
CG476_012855	COG3409	Peptidoglycan-binding domain 1 protein
CG476_012870	COG4145	pantothenate transmembrane transporter activity
CG476_012875	COG3924	membrane
CG476_012880	COG1012	belongs to the aldehyde dehydrogenase family
CG476_012890	COG1657	PFAM Prenyltransferase squalene oxidase
CG476_012895	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CG476_012900	COG2962	Rard protein
CG476_012935	COG2226	methyltransferase
CG476_012940	COG4166	transmembrane transport
CG476_012945	COG4166	transmembrane transport
CG476_012950	COG1301	dicarboxylic acid transport
CG476_012955	COG0673	inositol 2-dehydrogenase activity
CG476_012960	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CG476_012965	COG0187	DNA topoisomerase II activity
CG476_012975	COG1832	CoA-binding protein
CG476_012980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CG476_012985	COG0745	RESPONSE REGULATOR receiver
CG476_013000	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CG476_013005	COG4841	protein insertion into membrane
CG476_013015	COG0824	Thioesterase
CG476_013045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG476_013050	COG3655	Transcriptional regulator
CG476_013070	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CG476_013080	COG0726	polysaccharide deacetylase
CG476_013110	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CG476_013115	COG0318	PFAM AMP-dependent synthetase and ligase
CG476_013145	COG0457	Tetratricopeptide repeat
CG476_013220	COG2826	transposase and inactivated derivatives, IS30 family
CG476_013235	COG0534	Mate efflux family protein
CG476_013265	COG3023	N-Acetylmuramoyl-L-alanine amidase
CG476_013275	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG476_013285	COG5002	protein histidine kinase activity
CG476_013290	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG476_013295	COG0010	Belongs to the arginase family
CG476_013300	COG1228	amidohydrolase
CG476_013305	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CG476_013310	COG2986	histidine ammonia-lyase
CG476_013330	COG4846	Membrane protein involved in cytochrome C biogenesis
CG476_013335	COG0785	Cytochrome C biogenesis protein
CG476_013350	COG0583	DNA-binding transcription factor activity
CG476_013355	COG1380	Effector of murein hydrolase LrgA
CG476_013360	COG1346	cytolysis
CG476_013365	COG4187	Peptidase family M20/M25/M40
CG476_013375	COG0833	amino acid
CG476_013385	COG0730	response to heat
CG476_013395	COG5632	N-Acetylmuramoyl-L-alanine amidase
CG476_013395	COG3409	Peptidoglycan-binding domain 1 protein
CG476_013410	COG1132	(ABC) transporter
CG476_013415	COG1132	(ABC) transporter
CG476_013420	COG3763	UPF0154 protein
CG476_013435	COG3639	organic phosphonate transmembrane transporter activity
CG476_013440	COG3639	organic phosphonate transmembrane transporter activity
CG476_013455	COG0737	Belongs to the 5'-nucleotidase family
CG476_013460	COG4224	UPF0291 protein
CG476_013465	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CG476_013470	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CG476_013485	COG1695	Transcriptional regulator
CG476_013520	COG3328	transposase activity
CG476_013525	COG3328	transposase activity
CG476_013530	COG3328	transposase activity
CG476_013545	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG476_013570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG476_013590	COG0730	response to heat
CG476_013645	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CG476_013715	COG3723	Recombinational DNA repair protein, rece pathway
CG476_013760	COG0582	viral genome integration into host DNA
CG476_013765	COG0174	glutamine synthetase
CG476_013770	COG0789	Transcriptional regulator
CG476_013775	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CG476_013780	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CG476_013785	COG2860	membrane
CG476_013790	COG0464	growth
CG476_013805	COG1923	regulation of RNA biosynthetic process
CG476_013810	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CG476_013820	COG1388	LysM domain
CG476_013820	COG3584	3D domain protein
CG476_013825	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG476_013825	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG476_013825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG476_013830	COG1105	Belongs to the carbohydrate kinase PfkB family
CG476_013835	COG1349	DNA-binding transcription factor activity
CG476_013840	COG2322	membrane
CG476_013865	COG2116	formate transmembrane transporter activity
CG476_013875	COG1937	Protein conserved in bacteria
CG476_013880	COG2819	hydrolase of the alpha beta superfamily
CG476_013885	COG1120	ATPase activity
CG476_013890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG476_013895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG476_013900	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG476_013905	COG2706	6-phosphogluconolactonase activity
CG476_013910	COG2826	transposase and inactivated derivatives, IS30 family
CG476_013915	COG2195	Cleaves the N-terminal amino acid of tripeptides
CG476_013925	COG0346	lactoylglutathione lyase activity
CG476_013940	COG1113	amino acid transport
CG476_013965	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CG476_013970	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CG476_013980	COG4550	Control of competence regulator ComK, YlbF/YmcA
CG476_013985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CG476_013990	COG1013	pyruvate-flavodoxin oxidoreductase activity
CG476_013995	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CG476_013995	COG0674	pyruvate-flavodoxin oxidoreductase activity
CG476_014005	COG2359	stage V sporulation protein S
CG476_014010	COG1692	metallophosphoesterase
CG476_014015	COG1418	mRNA catabolic process
CG476_014020	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CG476_014025	COG1058	Belongs to the CinA family
CG476_014025	COG1546	Belongs to the CinA family
CG476_014030	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CG476_014035	COG1426	Protein conserved in bacteria
CG476_014050	COG0300	oxidoreductase activity
CG476_014055	COG0612	Peptidase, M16
CG476_014060	COG0612	Peptidase, M16
CG476_014085	COG2188	Transcriptional regulator
CG476_014105	COG0740	serine-type endopeptidase activity
CG476_014130	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CG476_014145	COG0527	aspartate kinase activity
CG476_014150	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CG476_014155	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CG476_014160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CG476_014165	COG1873	PFAM PRC-barrel domain
CG476_014170	COG0612	Peptidase, M16
CG476_014175	COG0726	polysaccharide deacetylase
CG476_014180	COG1185	polyribonucleotide nucleotidyltransferase activity
CG476_014190	COG0196	riboflavin kinase activity
CG476_014195	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CG476_014200	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CG476_014205	COG1550	Protein conserved in bacteria
CG476_014210	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CG476_014215	COG1358	cellular component organization or biogenesis
CG476_014220	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CG476_014225	COG0195	Participates in both transcription termination and antitermination
CG476_014230	COG0779	Required for maturation of 30S ribosomal subunits
CG476_014240	COG0442	prolyl-tRNA aminoacylation
CG476_014245	COG0750	zinc metalloprotease
CG476_014255	COG4589	Belongs to the CDS family
CG476_014265	COG0233	cytoplasmic translational termination
CG476_014270	COG0528	UMP kinase activity
CG476_014275	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CG476_014280	COG0052	Belongs to the universal ribosomal protein uS2 family
CG476_014285	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CG476_014290	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CG476_014295	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CG476_014300	COG4974	Belongs to the 'phage' integrase family
CG476_014305	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CG476_014310	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CG476_014315	COG0758	DNA mediated transformation
CG476_014320	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CG476_014325	COG0045	succinate-CoA ligase (ADP-forming) activity
CG476_014330	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CG476_014345	COG0335	large ribosomal subunit rRNA binding
CG476_014355	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CG476_014360	COG1837	Belongs to the UPF0109 family
CG476_014365	COG0228	four-way junction DNA binding
CG476_014370	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CG476_014375	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CG476_014380	COG0552	protein localization to endoplasmic reticulum
CG476_014385	COG1196	nuclear chromosome segregation
CG476_014390	COG0571	ribonuclease III activity
CG476_014400	COG1028	Short-chain dehydrogenase reductase Sdr
CG476_014405	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CG476_014410	COG0416	fatty acid biosynthetic process
CG476_014415	COG2050	protein possibly involved in aromatic compounds catabolism
CG476_014415	COG1349	DNA-binding transcription factor activity
CG476_014420	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CG476_014425	COG1461	Dihydroxyacetone kinase
CG476_014430	COG1302	Protein conserved in bacteria
CG476_014435	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CG476_014445	COG1564	THIamine pyrophosphokinase
CG476_014450	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CG476_014455	COG1162	GTPase activity
CG476_014460	COG0515	serine threonine protein kinase
CG476_014460	COG2815	serine threonine protein kinase
CG476_014465	COG0631	protein serine/threonine phosphatase activity
CG476_014470	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CG476_014475	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CG476_014475	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CG476_014480	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CG476_014485	COG0242	peptide deformylase activity
CG476_014490	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CG476_014495	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CG476_014500	COG1758	RNA polymerase activity
CG476_014505	COG0194	GDP metabolic process
CG476_014515	COG1561	YicC-like family, N-terminal region
CG476_014520	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CG476_014545	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CG476_014550	COG0284	orotidine-5'-phosphate decarboxylase activity
CG476_014555	COG0167	dihydroorotate dehydrogenase activity
CG476_014560	COG0543	2 iron, 2 sulfur cluster binding
CG476_014565	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CG476_014575	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CG476_014580	COG0540	Belongs to the ATCase OTCase family
CG476_014590	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CG476_014600	COG0564	pseudouridine synthase activity
CG476_014605	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CG476_014615	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CG476_014620	COG3599	regulation of cell shape
CG476_014625	COG2302	S4 RNA-binding domain
CG476_014630	COG0762	integral membrane protein
CG476_014635	COG1799	cell septum assembly
CG476_014640	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CG476_014650	COG1873	PFAM PRC-barrel domain
CG476_014655	COG1191	sigma factor activity
CG476_014660	COG1191	sigma factor activity
CG476_014670	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CG476_014675	COG0849	cell division
CG476_014680	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CG476_014690	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CG476_014695	COG0772	Belongs to the SEDS family
CG476_014700	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CG476_014705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CG476_014710	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CG476_014715	COG0768	penicillin binding
CG476_014725	COG4839	cell division protein FtsL
CG476_014730	COG0275	rRNA processing
CG476_014735	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CG476_014740	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CG476_014760	COG1399	metal-binding, possibly nucleic acid-binding protein
CG476_014870	COG4626	Terminase
CG476_014870	COG1802	Transcriptional regulator
CG476_014960	COG0756	dUTP diphosphatase activity
CG476_014990	COG3723	Recombinational DNA repair protein, rece pathway
CG476_015000	COG5377	YqaJ viral recombinase family
CG476_015045	COG0582	viral genome integration into host DNA
CG476_015050	COG1323	Belongs to the UPF0348 family
CG476_015055	COG3480	Lon protease (S16) C-terminal proteolytic domain
CG476_015060	COG1752	Esterase of the alpha-beta hydrolase superfamily
CG476_015065	COG3314	Sporulation integral membrane protein YlbJ
CG476_015070	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CG476_015075	COG0742	ribosomal rna small subunit methyltransferase
CG476_015085	COG4471	UPF0298 protein
CG476_015090	COG3679	Belongs to the UPF0342 family
CG476_015095	COG0406	alpha-ribazole phosphatase activity
CG476_015110	COG2340	Cysteine-rich secretory protein family
CG476_015120	COG3336	cytochrome c oxidase
CG476_015145	COG0109	protoheme IX farnesyltransferase activity
CG476_015150	COG1612	heme a metabolic process
CG476_015155	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CG476_015165	COG0772	Belongs to the SEDS family
CG476_015170	COG4838	Belongs to the UPF0358 family
CG476_015175	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CG476_015180	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CG476_015190	COG4896	Protein conserved in bacteria
CG476_015215	COG0483	inositol monophosphate 1-phosphatase activity
CG476_015225	COG4493	Belongs to the UPF0637 family
CG476_015230	COG4476	Belongs to the UPF0223 family
CG476_015235	COG1982	Orn Lys Arg decarboxylase major
CG476_015275	COG0508	dehydrogenase complex catalyzes the overall conversion of
CG476_015285	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CG476_015300	COG0561	phosphatase activity
CG476_015315	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CG476_015320	COG0569	domain protein
CG476_015330	COG1473	amidohydrolase
CG476_015335	COG2171	N-acyltransferase activity
CG476_015340	COG0583	DNA-binding transcription factor activity
CG476_015345	COG0517	IMP dehydrogenase activity
CG476_015355	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CG476_015375	COG4703	Protein of unknown function (DUF1797)
CG476_015390	COG2200	EAL domain
CG476_015395	COG1028	Short-chain dehydrogenase reductase Sdr
CG476_015400	COG1408	metallophosphoesterase
CG476_015410	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CG476_015450	COG2814	Major facilitator Superfamily
CG476_015455	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CG476_015465	COG3209	COG3209 Rhs family protein
CG476_015475	COG2205	protein histidine kinase activity
CG476_015485	COG0436	Aminotransferase
CG476_015490	COG1609	Transcriptional regulator
CG476_015495	COG3833	ABC-type maltose transport systems, permease component
CG476_015500	COG1175	transmembrane transport
CG476_015505	COG2182	Extracellular solute-binding protein
CG476_015520	COG0366	Alpha amylase catalytic
CG476_015525	COG3842	ATPase activity
CG476_015555	COG0183	Belongs to the thiolase family
CG476_015585	COG1695	Transcriptional regulator
CG476_015590	COG1028	Short-chain dehydrogenase reductase Sdr
CG476_015600	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CG476_015605	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CG476_015610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CG476_015615	COG0436	Aminotransferase
CG476_015620	COG1850	ribulose-bisphosphate carboxylase activity
CG476_015625	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
CG476_015630	COG0235	Class ii aldolase
CG476_015635	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CG476_015650	COG2084	Dehydrogenase
CG476_015665	COG0778	Nitroreductase
CG476_015690	COG1263	PTS System
CG476_015690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG476_015690	COG2190	(PTS) system
CG476_015695	COG3711	transcriptional antiterminator
CG476_015710	COG0363	glucosamine-6-phosphate deaminase activity
CG476_015725	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CG476_015730	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CG476_015740	COG1547	Domain of unknown function (DUF309)
CG476_015750	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CG476_015755	COG4086	secreted protein
CG476_015760	COG0561	phosphatase activity
CG476_015765	COG0697	spore germination
CG476_015780	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CG476_015805	COG0733	neurotransmitter:sodium symporter activity
CG476_015815	COG2172	sigma factor antagonist activity
CG476_015825	COG1686	Belongs to the peptidase S11 family
CG476_015835	COG1725	Transcriptional regulator
CG476_015840	COG1131	(ABC) transporter
CG476_015865	COG1846	Transcriptional regulator
CG476_015880	COG0598	Magnesium transport protein CorA
CG476_015910	COG4974	Belongs to the 'phage' integrase family
CG476_015920	COG0735	belongs to the Fur family
CG476_015925	COG1300	Membrane
CG476_015945	COG0667	Aldo Keto reductase
CG476_015950	COG0656	L-ascorbic acid biosynthetic process
CG476_015955	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CG476_015955	COG0456	acetyltransferase
CG476_015965	COG0737	Belongs to the 5'-nucleotidase family
CG476_015965	COG1525	nuclease
CG476_015965	COG4085	toxin activity
CG476_015975	COG0596	Alpha beta hydrolase
CG476_015980	COG2056	Na+-H+ antiporter family
CG476_015985	COG1609	Transcriptional regulator
CG476_015990	COG0456	acetyltransferase
CG476_015995	COG1073	alpha beta
CG476_016010	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CG476_016010	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CG476_016015	COG0307	riboflavin synthase, alpha
CG476_016020	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CG476_016020	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CG476_016035	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CG476_016040	COG4106	trans-aconitate 2-methyltransferase activity
CG476_016045	COG0596	Alpha beta hydrolase
CG476_016050	COG0156	8-amino-7-oxononanoate synthase activity
CG476_016060	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CG476_016075	COG0737	Belongs to the 5'-nucleotidase family
CG476_016100	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CG476_016110	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CG476_016120	COG0300	oxidoreductase activity
CG476_016125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG476_016130	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CG476_016135	COG1760	l-serine dehydratase
CG476_016140	COG1760	l-serine dehydratase
CG476_016150	COG1234	tRNA 3'-trailer cleavage
CG476_016170	COG2195	Cleaves the N-terminal amino acid of tripeptides
CG476_016175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG476_016190	COG1376	ErfK ybiS ycfS ynhG family protein
CG476_016195	COG4129	membrane
CG476_016200	COG1126	abc transporter atp-binding protein
CG476_016205	COG0765	amino acid transport
CG476_016210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG476_016225	COG2816	NAD+ diphosphatase activity
CG476_016230	COG0772	Belongs to the SEDS family
CG476_016240	COG0508	dehydrogenase complex catalyzes the overall conversion of
CG476_016245	COG0022	dehydrogenase e1 component
CG476_016250	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CG476_016255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CG476_016260	COG3426	butyrate kinase activity
CG476_016265	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CG476_016270	COG0280	phosphate acetyltransferase
CG476_016280	COG3829	transcription factor binding
CG476_016280	COG3290	protein histidine kinase activity
CG476_016290	COG0584	glycerophosphoryl diester phosphodiesterase
CG476_016295	COG3093	addiction module antidote protein HigA
CG476_016300	COG0745	RESPONSE REGULATOR receiver
CG476_016305	COG0750	zinc metalloprotease
CG476_016310	COG0497	DNA recombination
CG476_016320	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CG476_016325	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CG476_016335	COG1722	exodeoxyribonuclease VII activity
CG476_016340	COG1570	exodeoxyribonuclease VII activity
CG476_016345	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CG476_016350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CG476_016355	COG1302	Protein conserved in bacteria
CG476_016360	COG0439	Biotin carboxylase
CG476_016365	COG0511	ligase activity, forming carbon-carbon bonds
CG476_016410	COG3854	ATPases associated with a variety of cellular activities
CG476_016430	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CG476_016435	COG0006	proline dipeptidase activity
CG476_016440	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CG476_016450	COG3872	metal-dependent enzyme
CG476_016460	COG1321	iron dependent repressor
CG476_016475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CG476_016485	COG1609	Transcriptional regulator
CG476_016495	COG2076	Multidrug Resistance protein
CG476_016500	COG2076	Multidrug Resistance protein
CG476_016525	COG1131	(ABC) transporter
CG476_016530	COG1725	Transcriptional regulator
CG476_016545	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CG476_016550	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CG476_016555	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CG476_016560	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CG476_016590	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CG476_016615	COG1459	type II secretion system
CG476_016640	COG4824	toxin secretion phage lysis holin
CG476_016725	COG3728	DNA packaging
CG476_016735	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CG476_016800	COG1484	DNA-dependent DNA replication
CG476_016815	COG3723	Recombinational DNA repair protein, rece pathway
CG476_016820	COG5377	YqaJ viral recombinase family
CG476_016845	COG1396	sequence-specific DNA binding
CG476_016860	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CG476_016895	COG1078	dGTPase activity
CG476_016910	COG1410	methionine synthase
CG476_016910	COG0646	methionine synthase
CG476_016915	COG0646	methionine synthase
CG476_016915	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CG476_016920	COG0626	cystathionine gamma-synthase activity
CG476_016925	COG0626	cystathionine gamma-synthase activity
CG476_016945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG476_016955	COG1940	carbohydrate kinase activity
CG476_016960	COG4483	Protein conserved in bacteria
CG476_016965	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CG476_016970	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CG476_016980	COG0704	Plays a role in the regulation of phosphate uptake
CG476_016985	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CG476_016990	COG0581	inorganic phosphate transmembrane transporter activity
CG476_016995	COG0573	inorganic phosphate transmembrane transporter activity
CG476_017000	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CG476_017010	COG0477	Major facilitator Superfamily
CG476_017015	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CG476_017035	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CG476_017040	COG0735	belongs to the Fur family
CG476_017045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CG476_017050	COG1121	(ABC) transporter
CG476_017055	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG476_017065	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CG476_017080	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CG476_017085	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CG476_017090	COG2384	SAM-dependent methyltransferase
CG476_017100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CG476_017105	COG0358	DNA primase activity
CG476_017110	COG1671	Belongs to the UPF0178 family
CG476_017115	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CG476_017120	COG0517	IMP dehydrogenase activity
CG476_017125	COG1381	Involved in DNA repair and RecF pathway recombination
CG476_017135	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CG476_017145	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CG476_017150	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CG476_017155	COG1480	7TM receptor with intracellular HD hydrolase
CG476_017160	COG1702	phosphate starvation-inducible protein PhoH
CG476_017175	COG1610	YqeY-like protein
CG476_017180	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CG476_017185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CG476_017190	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CG476_017195	COG2264	protein methyltransferase activity
CG476_017200	COG0484	heat shock protein binding
CG476_017205	COG0443	Heat shock 70 kDa protein
CG476_017210	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CG476_017215	COG1420	regulation of RNA biosynthetic process
CG476_017220	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CG476_017225	COG1733	regulation of RNA biosynthetic process
CG476_017230	COG0693	protein deglycase activity
CG476_017235	COG0481	GTPase activity
CG476_017250	COG0268	Binds directly to 16S ribosomal RNA
CG476_017255	COG1466	dna polymerase III delta subunit
CG476_017265	COG2333	competence protein COMEC
CG476_017265	COG0658	competence protein
CG476_017270	COG2131	deaminase
CG476_017275	COG1555	photosystem II stabilization
CG476_017275	COG1596	polysaccharide export
CG476_017280	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CG476_017285	COG2226	methyltransferase
CG476_017290	COG0799	negative regulation of ribosome biogenesis
CG476_017295	COG1713	HD superfamily hydrolase involved in NAD metabolism
CG476_017300	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CG476_017305	COG1534	Rna-binding protein
CG476_017310	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CG476_017315	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CG476_017320	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CG476_017330	COG0688	phosphatidylethanolamine metabolic process
CG476_017335	COG1191	sigma factor activity
CG476_017345	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CG476_017350	COG2357	RelA SpoT domain protein
CG476_017355	COG1785	Belongs to the alkaline phosphatase family
CG476_017360	COG0456	acetyltransferase
CG476_017365	COG2267	carboxylic ester hydrolase activity
CG476_017390	COG3186	Phenylalanine-4-hydroxylase
CG476_017395	COG2154	pterin-4-alpha-carbinolamine dehydratase
CG476_017400	COG2514	catechol 2,3-dioxygenase activity
CG476_017405	COG2259	Doxx family
CG476_017420	COG1609	Transcriptional regulator
CG476_017430	COG0626	cystathionine gamma-synthase activity
CG476_017435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CG476_017440	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CG476_017445	COG2226	methyltransferase
CG476_017460	COG0768	penicillin binding
CG476_017470	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CG476_017475	COG0572	uridine kinase
CG476_017495	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CG476_017505	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CG476_017510	COG4472	Bacterial protein of unknown function (DUF965)
CG476_017515	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CG476_017520	COG0628	permease
CG476_017540	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CG476_017550	COG0482	sulfurtransferase activity
CG476_017555	COG1104	cysteine desulfurase activity
CG476_017560	COG1959	2 iron, 2 sulfur cluster binding
CG476_017565	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CG476_017585	COG2207	Transcriptional regulator
CG476_017595	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CG476_017600	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CG476_017605	COG0124	histidyl-tRNA synthetase
CG476_017625	COG1490	D-aminoacyl-tRNA deacylase activity
CG476_017630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CG476_017635	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CG476_017640	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CG476_017640	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CG476_017645	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CG476_017650	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CG476_017650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CG476_017660	COG2244	polysaccharide biosynthetic process
CG476_017685	COG1862	Preprotein translocase
CG476_017690	COG0343	queuine tRNA-ribosyltransferase activity
CG476_017695	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CG476_017705	COG2255	four-way junction helicase activity
CG476_017710	COG0632	four-way junction helicase activity
CG476_017715	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CG476_017735	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CG476_017740	COG0157	Belongs to the NadC ModD family
CG476_017745	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CG476_017750	COG1104	cysteine desulfurase activity
CG476_017755	COG1827	regulation of RNA biosynthetic process
CG476_017760	COG2258	MOSC domain
CG476_017765	COG0077	Prephenate dehydratase
CG476_017770	COG0577	efflux transmembrane transporter activity
CG476_017775	COG0577	efflux transmembrane transporter activity
CG476_017780	COG1136	(ABC) transporter
CG476_017785	COG5002	protein histidine kinase activity
CG476_017790	COG0745	RESPONSE REGULATOR receiver
CG476_017800	COG3290	protein histidine kinase activity
CG476_017805	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CG476_017810	COG2868	ribosomal protein
CG476_017820	COG1530	ribonuclease E activity
CG476_017825	COG1994	Peptidase M50
CG476_017830	COG0739	heme binding
CG476_017835	COG2894	cell division
CG476_017840	COG0850	regulation of cytokinetic process
CG476_017850	COG1792	Involved in formation and maintenance of cell shape
CG476_017855	COG1077	Cell shape determining protein MreB Mrl
CG476_017875	COG0424	maF-like protein
CG476_017885	COG0285	dihydrofolate synthase activity
CG476_017910	COG1388	LysM domain
CG476_017910	COG1388	LysM domain
CG476_017915	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CG476_017920	COG0113	porphobilinogen synthase activity
CG476_017925	COG1587	Uroporphyrinogen-III synthase
CG476_017930	COG0181	hydroxymethylbilane synthase activity
CG476_017935	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CG476_017940	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CG476_017945	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CG476_017955	COG0470	DNA polymerase III
CG476_017955	COG1067	ATP-dependent peptidase activity
CG476_017960	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CG476_017965	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG476_017990	COG4221	oxidoreductase activity
CG476_017990	COG3321	synthase
CG476_017990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CG476_017990	COG1028	Short-chain dehydrogenase reductase Sdr
CG476_018005	COG2409	Drug exporters of the RND superfamily
CG476_018005	COG1033	growth of symbiont in host cell
CG476_018015	COG1309	transcriptional regulator
CG476_018075	COG0622	Phosphoesterase
CG476_018085	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CG476_018090	COG5401	PFAM Sporulation and spore germination
CG476_018100	COG2197	response regulator
CG476_018110	COG1959	2 iron, 2 sulfur cluster binding
CG476_018115	COG1668	transmembrane transport
CG476_018120	COG4152	abc transporter atp-binding protein
CG476_018125	COG1360	Flagellar Motor Protein
CG476_018130	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CG476_018140	COG1876	peptidase activity
CG476_018150	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CG476_018155	COG1053	succinate dehydrogenase
CG476_018160	COG2009	succinate dehydrogenase
CG476_018165	COG1719	4-vinyl reductase, 4VR
CG476_018180	COG3118	belongs to the thioredoxin family
CG476_018185	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CG476_018190	COG2086	electron transfer activity
CG476_018195	COG1024	Enoyl-CoA hydratase
CG476_018200	COG1309	transcriptional regulator
CG476_018205	COG0318	PFAM AMP-dependent synthetase and ligase
CG476_018215	COG2318	DinB family
CG476_018235	COG1131	(ABC) transporter
CG476_018240	COG2205	protein histidine kinase activity
CG476_018245	COG0745	RESPONSE REGULATOR receiver
CG476_018255	COG4895	conserved protein (DUF2196)
CG476_018260	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CG476_018265	COG1114	Component of the transport system for branched-chain amino acids
CG476_018270	COG1187	pseudouridine synthase activity
CG476_018280	COG1193	negative regulation of DNA recombination
CG476_018285	COG1796	DNA polymerase
CG476_018285	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CG476_018290	COG1286	toxin biosynthetic process
CG476_018295	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CG476_018320	COG0017	Asparaginyl-tRNA synthetase
CG476_018325	COG0072	phenylalanine-tRNA ligase activity
CG476_018325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CG476_018330	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CG476_018335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CG476_018345	COG1418	mRNA catabolic process
CG476_018360	COG2814	Major facilitator Superfamily
CG476_018365	COG1566	PFAM secretion protein HlyD family protein
CG476_018370	COG1309	transcriptional regulator
CG476_018375	COG1363	Peptidase, m42
CG476_018385	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CG476_018390	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CG476_018395	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CG476_018400	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CG476_018410	COG1484	DNA-dependent DNA replication
CG476_018415	COG3611	Membrane attachment protein
CG476_018420	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CG476_018425	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CG476_018435	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CG476_018445	COG1971	Probably functions as a manganese efflux pump
CG476_018455	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CG476_018455	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CG476_018460	COG5002	protein histidine kinase activity
CG476_018465	COG0745	RESPONSE REGULATOR receiver
CG476_018475	COG0039	L-malate dehydrogenase activity
CG476_018480	COG0538	isocitrate dehydrogenase activity
CG476_018485	COG0372	Belongs to the citrate synthase family
CG476_018490	COG2707	UPF0756 membrane protein
CG476_018495	COG0628	permease
CG476_018500	COG3030	protein affecting phage T7 exclusion by the F plasmid
CG476_018510	COG0205	6-phosphofructokinase activity
CG476_018515	COG0825	malonyl-CoA metabolic process
CG476_018520	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CG476_018525	COG1725	Transcriptional regulator
CG476_018530	COG0281	malic enzyme
CG476_018535	COG0587	DNA-directed DNA polymerase activity
CG476_018550	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CG476_018560	COG4109	DRTGG domain
CG476_018565	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CG476_018570	COG0006	proline dipeptidase activity
CG476_018595	COG1028	Short-chain dehydrogenase reductase Sdr
CG476_018600	COG0589	response to stress
CG476_018625	COG0165	Argininosuccinate lyase
CG476_018630	COG0137	argininosuccinate synthase activity
CG476_018640	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG476_018650	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CG476_018655	COG0827	DNA restriction-modification system
CG476_018660	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CG476_018665	COG3874	Sporulation protein YtfJ
CG476_018675	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CG476_018680	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CG476_018685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CG476_018695	COG0301	tRNA thio-modification
CG476_018700	COG1104	cysteine desulfurase activity
CG476_018705	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CG476_018710	COG0583	DNA-binding transcription factor activity
CG476_018715	COG0697	spore germination
CG476_018720	COG1309	transcriptional regulator
CG476_018725	COG1956	GAF domain-containing protein
CG476_018730	COG0626	cystathionine gamma-synthase activity
CG476_018740	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CG476_018765	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CG476_018775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CG476_018780	COG0454	-acetyltransferase
CG476_018785	COG0517	IMP dehydrogenase activity
CG476_018790	COG0123	including yeast histone deacetylase and acetoin utilization protein
CG476_018795	COG1970	mechanosensitive ion channel activity
CG476_018805	COG1609	Transcriptional regulator
CG476_018815	COG1605	Chorismate mutase
CG476_018815	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CG476_018820	COG3118	belongs to the thioredoxin family
CG476_018830	COG2309	aminopeptidase activity
CG476_018845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CG476_018855	COG1674	ftsk spoiiie
CG476_018865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CG476_018870	COG4848	Belongs to the UPF0354 family
CG476_018875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG476_018880	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CG476_018900	COG1363	Peptidase, m42
CG476_018910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG476_018915	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CG476_018925	COG0510	thiamine kinase activity
CG476_018930	COG1523	belongs to the glycosyl hydrolase 13 family
CG476_018940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CG476_018945	COG1349	DNA-binding transcription factor activity
CG476_018950	COG1187	pseudouridine synthase activity
CG476_018955	COG2244	polysaccharide biosynthetic process
CG476_018960	COG2081	HI0933 family
CG476_018965	COG2814	Major facilitator Superfamily
CG476_018975	COG3832	glyoxalase III activity
CG476_018995	COG1329	Transcriptional regulator
CG476_019005	COG2223	nitrite transmembrane transporter activity
CG476_019015	COG0314	molybdopterin synthase activity
CG476_019020	COG1763	Mo-molybdopterin cofactor biosynthetic process
CG476_019025	COG0303	'Molybdopterin
CG476_019030	COG0315	cyclic pyranopterin monophosphate synthase activity
CG476_019035	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG476_019040	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CG476_019045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CG476_019050	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CG476_019055	COG1140	nitrate reductase beta subunit
CG476_019060	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CG476_019065	COG2181	nitrate reductase activity
CG476_019080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CG476_019090	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CG476_019125	COG0495	leucyl-tRNA aminoacylation
CG476_019130	COG2814	Major facilitator Superfamily
CG476_019140	COG1136	(ABC) transporter
CG476_019145	COG0346	lactoylglutathione lyase activity
CG476_019160	COG1242	4 iron, 4 sulfur cluster binding
CG476_019165	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CG476_019170	COG1121	(ABC) transporter
CG476_019180	COG1794	racemase activity, acting on amino acids and derivatives
CG476_019190	COG2378	regulation of single-species biofilm formation
CG476_019200	COG2267	carboxylic ester hydrolase activity
CG476_019215	COG0746	molybdenum cofactor guanylyltransferase activity
CG476_019240	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CG476_019250	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CG476_019300	COG0800	Aldolase
CG476_019305	COG2610	gluconate transmembrane transporter activity
CG476_019310	COG1312	Catalyzes the dehydration of D-mannonate
CG476_019320	COG1414	Transcriptional regulator
CG476_019325	COG3409	Peptidoglycan-binding domain 1 protein
CG476_019325	COG5632	N-Acetylmuramoyl-L-alanine amidase
CG476_019335	COG1368	sulfuric ester hydrolase activity
CG476_019350	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CG476_019355	COG1116	anion transmembrane transporter activity
CG476_019360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG476_019375	COG0494	nUDIX hydrolase
CG476_019385	COG1854	S-ribosylhomocysteine lyase activity
CG476_019390	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CG476_019395	COG0288	reversible hydration of carbon dioxide
CG476_019400	COG1271	oxidase subunit
CG476_019405	COG1294	oxidase, subunit
CG476_019435	COG1842	Phage shock protein A
CG476_019480	COG1597	lipid kinase activity
CG476_019485	COG1136	(ABC) transporter
CG476_019495	COG0745	RESPONSE REGULATOR receiver
CG476_019500	COG2205	protein histidine kinase activity
CG476_019505	COG0577	efflux transmembrane transporter activity
CG476_019510	COG1136	(ABC) transporter
CG476_019530	COG4948	Mandelate Racemase Muconate Lactonizing
CG476_019535	COG0318	PFAM AMP-dependent synthetase and ligase
CG476_019540	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CG476_019545	COG0596	Alpha beta hydrolase
CG476_019550	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CG476_019555	COG1169	isochorismate synthase
CG476_019560	COG1575	Belongs to the MenA family. Type 1 subfamily
CG476_019565	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CG476_019570	COG1278	Cold shock
CG476_019590	COG0058	SHG alpha-glucan phosphorylase activity
CG476_019595	COG0297	glycogen (starch) synthase activity
CG476_019600	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CG476_019605	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CG476_019610	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CG476_019615	COG0039	L-malate dehydrogenase activity
CG476_019710	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG476_019745	COG1285	pathogenesis
CG476_019750	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CG476_019760	COG0166	Belongs to the GPI family
CG476_019770	COG2155	Conserved Protein
CG476_019775	COG1098	S1 RNA binding domain
CG476_019780	COG0436	Aminotransferase
CG476_019785	COG1522	sequence-specific DNA binding
CG476_019790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CG476_019795	COG2267	carboxylic ester hydrolase activity
CG476_019805	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CG476_019810	COG2032	superoxide dismutase activity
CG476_019820	COG5018	Exonuclease
CG476_019825	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CG476_019830	COG0423	glycine-tRNA ligase activity
CG476_019850	COG2050	protein possibly involved in aromatic compounds catabolism
CG476_019860	COG1268	BioY protein
CG476_019865	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CG476_019870	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CG476_019880	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CG476_019890	COG3584	3D domain protein
CG476_019910	COG1252	NADH dehydrogenase
CG476_019915	COG0492	ferredoxin-NADP+ reductase activity
CG476_019930	COG1683	Conserved Protein
CG476_019965	COG1131	(ABC) transporter
CG476_019990	COG0316	Belongs to the HesB IscA family
CG476_019995	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CG476_020000	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG476_020010	COG1252	NADH dehydrogenase
CG476_020015	COG2824	Alkylphosphonate utilization operon protein PhnA
CG476_020025	COG3655	Transcriptional regulator
CG476_020040	COG4837	Protein of unknown function (DUF1462)
CG476_020045	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CG476_020050	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG476_020055	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CG476_020060	COG0647	UMP catabolic process
CG476_020070	COG2445	Protein of unknown function DUF86
CG476_020075	COG1494	fructose-1,6-bisphosphatase
CG476_020085	COG4470	Protein conserved in bacteria
CG476_020095	COG0789	Transcriptional regulator
CG476_020100	COG4377	Putative membrane peptidase family (DUF2324)
CG476_020115	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CG476_020120	COG0739	heme binding
CG476_020130	COG3377	Domain of unknown function (DUF1805)
CG476_020135	COG0737	Belongs to the 5'-nucleotidase family
CG476_020155	COG0719	Fe-S assembly protein
CG476_020160	COG0822	iron-sulfur transferase activity
CG476_020165	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CG476_020170	COG0719	Fe-S assembly protein
CG476_020175	COG0396	ATPase activity
CG476_020180	COG1464	Belongs to the NlpA lipoprotein family
CG476_020185	COG2011	ABC-type metal ion transport system permease component
CG476_020200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG476_020205	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CG476_020215	COG0509	glycine decarboxylation via glycine cleavage system
CG476_020220	COG1393	Belongs to the ArsC family
CG476_020260	COG1960	acyl-CoA dehydrogenase activity
CG476_020265	COG0183	Belongs to the thiolase family
CG476_020270	COG1024	Enoyl-CoA hydratase
CG476_020270	COG1250	3-hydroxyacyl-CoA dehydrogenase
CG476_020280	COG1686	Belongs to the peptidase S11 family
CG476_020305	COG0011	TIGRFAM Protein of
CG476_020310	COG0840	transmembrane signaling receptor activity
CG476_020330	COG0531	amino acid
CG476_020335	COG0706	membrane insertase activity
CG476_020345	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG476_020355	COG0586	Pfam SNARE associated Golgi protein
CG476_020365	COG1376	ErfK ybiS ycfS ynhG family protein
CG476_020370	COG0745	RESPONSE REGULATOR receiver
CG476_020375	COG5002	protein histidine kinase activity
CG476_020380	COG0840	transmembrane signaling receptor activity
CG476_020385	COG0840	transmembrane signaling receptor activity
CG476_020390	COG2151	metal-sulfur cluster biosynthetic enzyme
CG476_020395	COG3227	Zinc metalloprotease (Elastase)
CG476_020400	COG1741	Belongs to the pirin family
CG476_020415	COG0783	Belongs to the Dps family
CG476_020420	COG1611	Belongs to the LOG family
CG476_020440	COG0803	Belongs to the bacterial solute-binding protein 9 family
CG476_020445	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CG476_020450	COG1121	(ABC) transporter
CG476_020470	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG476_020475	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG476_020480	COG1115	amino acid carrier protein
CG476_020485	COG2910	NAD(P)H-binding
CG476_020500	COG1252	NADH dehydrogenase
CG476_020515	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CG476_020530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CG476_020535	COG1917	Cupin 2, conserved barrel domain protein
CG476_020535	COG4977	sequence-specific DNA binding
CG476_020540	COG3223	Belongs to the PsiE family
CG476_020545	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CG476_020565	COG0697	spore germination
CG476_020580	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CG476_020585	COG0557	exoribonuclease II activity
CG476_020590	COG1647	Serine aminopeptidase, S33
CG476_020595	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CG476_020600	COG1346	cytolysis
CG476_020610	COG0148	phosphopyruvate hydratase activity
CG476_020615	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CG476_020620	COG0149	triose-phosphate isomerase activity
CG476_020625	COG0126	phosphoglycerate kinase activity
CG476_020630	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CG476_020645	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CG476_020695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CG476_020710	COG2323	membrane
CG476_020720	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG476_020725	COG1481	regulation of sporulation
CG476_020730	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CG476_020735	COG1660	Displays ATPase and GTPase activities
CG476_020740	COG1051	belongs to the nudix hydrolase family
CG476_020750	COG0492	ferredoxin-NADP+ reductase activity
CG476_020755	COG0457	Tetratricopeptide repeat
CG476_020760	COG0110	maltose O-acetyltransferase activity
CG476_020770	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CG476_020775	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CG476_020780	COG1950	PFAM Membrane protein of
CG476_020790	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CG476_020805	COG0789	Transcriptional regulator
CG476_020825	COG0583	DNA-binding transcription factor activity
CG476_020840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CG476_020845	COG0793	Belongs to the peptidase S41A family
CG476_020845	COG3409	Peptidoglycan-binding domain 1 protein
CG476_020850	COG2177	Part of the ABC transporter FtsEX involved in
CG476_020855	COG2884	Cell division ATP-binding protein ftsE
CG476_020890	COG1278	Cold shock
CG476_020895	COG1040	competence protein
CG476_020900	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CG476_020905	COG0791	NLP P60 protein
CG476_020905	COG1388	LysM domain
CG476_020910	COG1733	regulation of RNA biosynthetic process
CG476_020915	COG1307	EDD domain protein, DegV family
CG476_020920	COG1739	Uncharacterized protein family UPF0029
CG476_020925	COG1316	TRANSCRIPTIONal
CG476_020935	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CG476_020945	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CG476_020955	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CG476_020955	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CG476_020970	COG1486	melibiose metabolic process
CG476_020975	COG1447	Phosphotransferase system cellobiose-specific component IIA
CG476_020990	COG1447	Phosphotransferase system cellobiose-specific component IIA
CG476_020995	COG1301	dicarboxylic acid transport
CG476_021000	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CG476_021010	COG1271	oxidase subunit
CG476_021015	COG1294	oxidase, subunit
CG476_021020	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CG476_021025	COG1620	l-lactate permease
CG476_021030	COG2389	metal-binding protein
CG476_021040	COG1368	sulfuric ester hydrolase activity
CG476_021050	COG0791	NLP P60 protein
CG476_021050	COG1388	LysM domain
CG476_021055	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG476_021065	COG1215	transferase activity, transferring glycosyl groups
CG476_021075	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CG476_021080	COG1388	LysM domain
CG476_021080	COG3584	3D domain protein
CG476_021095	COG4715	Zinc finger, swim domain protein
CG476_021100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CG476_021140	COG0577	efflux transmembrane transporter activity
CG476_021145	COG1136	(ABC) transporter
CG476_021180	COG3850	Histidine kinase
CG476_021180	COG5002	protein histidine kinase activity
CG476_021185	COG0745	RESPONSE REGULATOR receiver
CG476_021195	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CG476_021205	COG1215	transferase activity, transferring glycosyl groups
CG476_021205	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CG476_021210	COG1134	teichoic acid transport
CG476_021215	COG1682	transport, permease protein
CG476_021220	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CG476_021225	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CG476_021225	COG0463	Glycosyl transferase, family 2
CG476_021230	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CG476_021235	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CG476_021250	COG1609	Transcriptional regulator
CG476_021260	COG0739	heme binding
CG476_021280	COG2385	sporulation resulting in formation of a cellular spore
CG476_021295	COG4836	Membrane
CG476_021300	COG1007	ATP synthesis coupled electron transport
CG476_021305	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG476_021310	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CG476_021315	COG0713	ATP synthesis coupled electron transport
CG476_021320	COG0839	Belongs to the complex I subunit 6 family
CG476_021330	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CG476_021335	COG0649	NAD binding
CG476_021340	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG476_021345	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG476_021350	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG476_021355	COG3300	MHYT domain
CG476_021355	COG5001	Diguanylate cyclase
CG476_021360	COG5001	Diguanylate cyclase
CG476_021360	COG3300	MHYT domain
CG476_021375	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CG476_021380	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CG476_021390	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CG476_021395	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CG476_021400	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CG476_021405	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CG476_021410	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CG476_021435	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CG476_021440	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CG476_021450	COG0698	ribose 5-phosphate isomerase
CG476_021470	COG2190	(PTS) system
CG476_021475	COG2259	Doxx family
CG476_021480	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CG476_021495	COG0009	L-threonylcarbamoyladenylate synthase
CG476_021510	COG2890	protein-(glutamine-N5) methyltransferase activity
CG476_021515	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CG476_021520	COG1435	thymidine kinase activity
CG476_021530	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CG476_021535	COG1494	fructose-1,6-bisphosphatase
CG476_021555	COG4821	SIS domain
CG476_021560	COG0504	CTP synthase activity
CG476_021575	COG1960	acyl-CoA dehydrogenase activity
CG476_021580	COG1960	acyl-CoA dehydrogenase activity
CG476_021585	COG1250	3-hydroxyacyl-CoA dehydrogenase
CG476_021590	COG0183	Belongs to the thiolase family
CG476_021595	COG0247	lactate metabolic process
CG476_021595	COG2181	nitrate reductase activity
CG476_021600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CG476_021615	COG2197	response regulator
CG476_021620	COG4585	Histidine kinase
CG476_021625	COG0842	Transport permease protein
CG476_021630	COG1131	(ABC) transporter
CG476_021635	COG0024	Methionine aminopeptidase
CG476_021640	COG2234	aminopeptidase activity
CG476_021655	COG4506	Protein conserved in bacteria
CG476_021660	COG1619	proteins homologs of microcin C7 resistance protein MccF
CG476_021675	COG0010	Belongs to the arginase family
CG476_021680	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CG476_021685	COG2814	Major facilitator Superfamily
CG476_021690	COG0789	Transcriptional regulator
CG476_021695	COG0584	glycerophosphoryl diester phosphodiesterase
CG476_021700	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG476_021710	COG1994	Peptidase M50
CG476_021720	COG1078	dGTPase activity
CG476_021725	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG476_021730	COG1120	ATPase activity
CG476_021735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG476_021740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG476_021745	COG4844	belongs to the
CG476_021760	COG0280	phosphate acetyltransferase
CG476_021775	COG3773	Cell wall hydrolase
CG476_021785	COG2363	Small membrane protein
CG476_021795	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CG476_021800	COG2233	PERMEase
CG476_021805	COG0561	phosphatase activity
CG476_021810	COG2814	Major facilitator Superfamily
CG476_021815	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CG476_021820	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CG476_021825	COG1131	(ABC) transporter
CG476_021830	COG2755	lipolytic protein G-D-S-L family
CG476_021835	COG0460	homoserine dehydrogenase
CG476_021840	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CG476_021855	COG0351	phosphomethylpyrimidine kinase
CG476_021865	COG1966	Carbon starvation protein
CG476_021870	COG3279	Response regulator of the LytR AlgR family
CG476_021875	COG0477	Major facilitator Superfamily
CG476_021885	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CG476_021890	COG0438	transferase activity, transferring glycosyl groups
CG476_021905	COG0840	transmembrane signaling receptor activity
CG476_021920	COG1607	acyl-coa hydrolase
CG476_021925	COG1216	Glycosyl transferase, family 2
CG476_021940	COG0463	Glycosyl transferase, family 2
CG476_021955	COG0463	Glycosyl transferase, family 2
CG476_021960	COG0488	(ABC) transporter
CG476_021965	COG1309	transcriptional regulator
CG476_021970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CG476_021975	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CG476_021975	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CG476_021980	COG0628	permease
CG476_021985	COG1346	cytolysis
CG476_021995	COG3279	Response regulator of the LytR AlgR family
CG476_022000	COG3275	phosphorelay sensor kinase activity
CG476_022005	COG2814	Major facilitator Superfamily
CG476_022010	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
CG476_022015	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CG476_022025	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CG476_022030	COG3711	transcriptional antiterminator
CG476_022030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG476_022085	COG0582	viral genome integration into host DNA
CG476_022100	COG1132	(ABC) transporter
CG476_022110	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CG476_022120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CG476_022125	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CG476_022130	COG4853	Protein conserved in bacteria
CG476_022140	COG5002	protein histidine kinase activity
CG476_022145	COG0745	RESPONSE REGULATOR receiver
CG476_022170	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CG476_022175	COG0305	Participates in initiation and elongation during chromosome replication
CG476_022180	COG0359	binds to the 23S rRNA
CG476_022185	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CG476_022190	COG4241	membrane
CG476_022195	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CG476_022200	COG0629	single-stranded DNA binding
CG476_022205	COG0360	Binds together with S18 to 16S ribosomal RNA
CG476_022210	COG0012	GTP binding
CG476_022215	COG4481	Protein conserved in bacteria
CG476_022220	COG0668	transmembrane transport
CG476_022230	COG1475	DNA binding
CG476_022235	COG1192	Involved in chromosome partitioning
CG476_022240	COG1475	DNA binding
CG476_022245	COG0357	Ribosomal RNA small subunit methyltransferase G
CG476_022250	COG0445	tRNA wobble uridine modification
CG476_022255	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CG476_022260	COG1847	R3H domain protein
CG476_022265	COG0706	membrane insertase activity
CG476_022270	COG0594	ribonuclease P activity
CG476_022395	COG2003	Belongs to the UPF0758 family
CG476_022410	COG3209	COG3209 Rhs family protein
CG476_022415	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CG476_022450	COG0457	Tetratricopeptide repeat
CG476_022485	COG1073	alpha beta
CG476_022495	COG2197	response regulator
CG476_022500	COG1476	TRANSCRIPTIONal
CG476_022680	COG1028	Short-chain dehydrogenase reductase Sdr
CG476_022700	COG0583	DNA-binding transcription factor activity
CG476_022715	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CG476_022795	COG4974	Belongs to the 'phage' integrase family
CG476_022830	COG4166	transmembrane transport
CG476_022840	COG0457	Tetratricopeptide repeat
CG476_022880	COG1192	Involved in chromosome partitioning
CG476_023030	COG0741	lytic transglycosylase activity
CG476_023030	COG0791	NLP P60 protein