locus-tag class description CG477_000005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) CG477_000010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CG477_000015 ENOG410848D S4 domain protein YaaA CG477_000020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) CG477_000030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CG477_000065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CG477_000075 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) CG477_000080 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) CG477_000085 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) CG477_000100 ENOG4105ZMH deoxynucleoside kinase CG477_000110 ENOG4105GTG Isochorismatase CG477_000115 ENOG4108Z6B deaminase CG477_000125 ENOG4105C6E dna polymerase iii CG477_000130 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) CG477_000135 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) CG477_000180 ENOG4105CXN decarboxylase CG477_000185 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) CG477_000190 ENOG4105FA2 dna polymerase iii CG477_000195 ENOG4105MA4 psp1 domain protein CG477_000200 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) CG477_000205 ENOG41060K3 Methyltransferase CG477_000215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) CG477_000220 ENOG4105KRN Transcriptional regulator, abrb family CG477_000225 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) CG477_000230 ENOG4105F8V Hydrolase, tatD family CG477_000235 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) CG477_000240 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) CG477_000245 ENOG4105XFA sporulation peptidase YabG CG477_000250 ENOG4105W42 Veg protein CG477_000260 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) CG477_000265 ENOG4105DFT pur operon repressor CG477_000270 ENOG4105KME endoribonuclease L-psp CG477_000280 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) CG477_000285 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CG477_000290 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) CG477_000300 ENOG4108JA2 transcriptioN-repair coupling factor CG477_000305 ENOG4108M14 stage v sporulation protein t CG477_000315 ENOG4108IY2 MazG family CG477_000320 ENOG41082I2 s4 domain protein CG477_000325 ENOG4105VYY sporulation protein yabp CG477_000340 ENOG41060GV RNA binding s1 domain protein CG477_000365 ENOG4108UGV hypoxanthine phosphoribosyltransferase CG477_000370 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CG477_000375 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) CG477_000380 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) CG477_000385 ENOG4105C6T cysteine synthase CG477_000390 ENOG4105CRQ synthase (Component I) CG477_000395 ENOG4105DDQ anthranilate synthase CG477_000400 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 CG477_000405 ENOG4105EEI dihydropteroate synthase CG477_000410 ENOG4105KRF dihydroneopterin aldolase CG477_000415 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CG477_000425 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CG477_000430 ENOG4105CRK lysyL-tRNA synthetase CG477_000465 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CG477_000515 ENOG4108Z0C Uvrb UvrC protein CG477_000520 ENOG41066A3 ATP guanido phosphotransferase CG477_000530 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CG477_000540 ENOG4105CTP PilT protein domain protein CG477_000545 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) CG477_000550 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) CG477_000555 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) CG477_000560 ENOG4105D7W serine acetyltransferase CG477_000565 ENOG4105C8N cysteinyl-tRNA synthetase CG477_000575 ENOG4105C2N RNA methyltransferase TrmH family group 3 CG477_000580 ENOG4105M0M Tetracycline resistance protein CG477_000585 ENOG4105QIV RNA polymerase CG477_000600 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) CG477_000610 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) CG477_000615 ENOG4108VZM 50s ribosomal protein L10 CG477_000620 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) CG477_000625 ENOG4107Y49 methyltransferase CG477_000635 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CG477_000640 ENOG4105XPM ribosomal protein CG477_000645 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) CG477_000650 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) CG477_000655 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) CG477_000660 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) CG477_000670 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) CG477_000675 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) CG477_000680 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) CG477_000685 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity CG477_000690 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) CG477_000695 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) CG477_000700 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) CG477_000705 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) CG477_000715 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal CG477_000720 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) CG477_000725 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) CG477_000730 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits CG477_000740 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) CG477_000745 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) CG477_000750 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) CG477_000755 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) CG477_000760 ENOG41084HK 50S ribosomal protein L30 CG477_000765 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) CG477_000770 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CG477_000775 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) CG477_000780 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CG477_000790 ENOG41067V7 50S ribosomal protein L36 CG477_000800 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) CG477_000805 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CG477_000815 ENOG4108JJB ABC transporter CG477_000820 ENOG4108JJB ABC transporter CG477_000825 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) CG477_000835 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) CG477_000840 ENOG4108UJD 30S ribosomal protein S9 CG477_000855 ENOG4105D1F ATP-binding protein CG477_000870 ENOG4108NMV polysaccharide deacetylase CG477_000900 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CG477_001055 ENOG4105C8B TIGR00159 family CG477_001065 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) CG477_001105 ENOG4105WT3 Transcriptional regulator CG477_001110 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) CG477_001210 ENOG4105CPF Cell wall formation (By similarity) CG477_001225 ENOG4105CEM UPF0597 protein CG477_001240 ENOG4105D7V transposase CG477_001250 ENOG4105C2C drug resistance transporter, Bcr CflA CG477_001260 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CG477_001265 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CG477_001270 ENOG4105C3U ABC transporter CG477_001275 ENOG4108JQ7 (ABC) transporter CG477_001300 ENOG4105MKU Transcriptional regulator CG477_001315 ENOG4105II7 pyrroline-5-carboxylate reductase CG477_001325 ENOG4105E0C molybdate abc transporter CG477_001330 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CG477_001335 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family CG477_001340 ENOG4105F6E Acyl-transferase CG477_001345 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) CG477_001350 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CG477_001355 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein CG477_001360 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CG477_001365 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit CG477_001370 ENOG4108IFG nitrite reductase, (NAD(P)H) CG477_001400 ENOG4105BZU Histidine kinase CG477_001405 ENOG4105WH1 Two component transcriptional regulator luxr family CG477_001410 ENOG4105CJ1 ABC, transporter CG477_001415 ENOG41090VJ ABC-2 type transporter CG477_001420 ENOG4108KYE ABC-2 type transporter CG477_001430 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein CG477_001440 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CG477_001445 ENOG4105C3U ABC transporter CG477_001450 ENOG4108JQ7 (ABC) transporter CG477_001475 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase CG477_001480 ENOG4105ERH Fumarylacetoacetate hydrolase CG477_001490 ENOG4108SC4 )-transporter CG477_001495 ENOG4105CPF Cell wall formation (By similarity) CG477_001500 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) CG477_001510 ENOG4107ZXI Rhomboid family CG477_001515 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) CG477_001520 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein CG477_001535 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) CG477_001590 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CG477_001640 ENOG4105K8N protein family UPF0079, ATPase CG477_001645 ENOG41072GX Peptidase M22 Glycoprotease CG477_001650 ENOG410801F ribosomal-protein-alanine acetyltransferase CG477_001655 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CG477_001660 ENOG4105C5H ABC transporter CG477_001675 ENOG4108TYN CAAX amino terminal protease family protein CG477_001680 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) CG477_001685 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) CG477_001690 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CG477_001695 ENOG4105C7N Xanthine uracil vitamin C permease CG477_001705 ENOG4105BZU Histidine kinase CG477_001780 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CG477_001800 ENOG4105SX7 Transporter CG477_001825 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CG477_001830 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit CG477_001835 ENOG4105C83 adenylosuccinate lyase CG477_001840 ENOG4105C8V SAICAR synthetase CG477_001845 ENOG4105VR9 phosphoribosylformylglycinamidine synthase CG477_001850 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I CG477_001855 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii CG477_001865 ENOG4105CXB phosphoribosylaminoimidazole synthetase CG477_001870 ENOG4108V3E phosphoribosylglycinamide formyltransferase CG477_001875 ENOG4105DC1 bifunctional purine biosynthesis protein purh CG477_001880 ENOG4105C12 Phosphoribosylglycinamide synthetase CG477_001915 ENOG4105C4R Atp-dependent dna helicase CG477_001920 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) CG477_001935 ENOG4105C26 Dehydrogenase CG477_001940 ENOG4108W2Y isochorismatase CG477_001950 ENOG4108UMI ABC transporter, permease CG477_001955 ENOG4105D01 (LipO)protein CG477_001970 ENOG4107I77 yiaA/B two helix domain CG477_001975 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CG477_001980 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CG477_001985 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CG477_001990 ENOG4105CBD Diacylglycerol kinase CG477_001995 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase CG477_002000 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) CG477_002005 ENOG4108JPW Aminotransferase CG477_002015 ENOG4105CUB amino acid CG477_002020 ENOG4105C26 Dehydrogenase CG477_002025 ENOG4105KPY Small multidrug resistance protein CG477_002045 ENOG4105D9N nucleoside CG477_002050 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CG477_002070 ENOG4105D3R alkyl hydroperoxide reductase CG477_002095 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CG477_002130 ENOG4105EHG Permease protein CG477_002135 ENOG4105DQ5 transport system permease protein CG477_002140 ENOG4108V5C ABC transporter CG477_002145 ENOG4105CAY ferredoxin--nadp reductase CG477_002160 ENOG4105BZU Histidine kinase CG477_002185 ENOG410756H nucleotidyltransferase CG477_002190 ENOG4105D2S major facilitator superfamily CG477_002205 ENOG4105E5Q amino acid AbC transporter CG477_002210 ENOG4105EAB amino acid AbC transporter CG477_002215 ENOG4105CDA abc transporter atp-binding protein CG477_002220 ENOG4105C8Q Methyl-accepting chemotaxis CG477_002235 ENOG4105CEU Arginine dihydrolase CG477_002240 ENOG4105DBV ornithine carbamoyltransferase CG477_002250 ENOG4105C5B carbamate kinase CG477_002255 ENOG4107RU9 Transcriptional regulator, Crp Fnr family CG477_002270 ENOG4105CI1 PTS System CG477_002290 ENOG4105DHS permease protein CG477_002295 ENOG4105CM4 permease protein CG477_002300 ENOG4108IPW abc transporter atp-binding protein CG477_002310 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase CG477_002315 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) CG477_002320 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter CG477_002340 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component CG477_002370 ENOG41062JF Transcriptional regulator CG477_002430 ENOG4105IYK transposase CG477_002435 ENOG4105DQ6 Transposase CG477_002440 ENOG4105DEU major facilitator superfamily CG477_002465 ENOG4108N0M stress protein CG477_002470 ENOG4106FN3 tellurium resistance protein CG477_002475 ENOG4106FN3 tellurium resistance protein CG477_002480 ENOG4107TS3 membrane protein, TerC CG477_002485 ENOG4108TTB tellurium resistance protein CG477_002505 ENOG4105KJF protein tyrosine phosphatase CG477_002515 ENOG4107U9T Pfam:Ribonuclease_BN CG477_002520 ENOG4105C59 p-type ATPase CG477_002525 ENOG4108IPJ Membrane CG477_002535 ENOG4105C3F Signal peptidase i CG477_002545 ENOG4107ZTW SNARE associated Golgi CG477_002560 ENOG4105UPD Calcium Proton CG477_002640 ENOG4107Y5K Resolvase CG477_002670 ENOG4105CSV Glutaminase CG477_002680 ENOG4108A04 Beta-lactamase CG477_002685 ENOG4107QQG Dehydrogenase CG477_002690 ENOG4105C3I Nad-dependent epimerase dehydratase CG477_002700 ENOG4105F1A Pyruvate formate-lyase CG477_002705 ENOG4108QBV Monogalactosyldiacylglycerol synthase CG477_002720 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) CG477_002725 ENOG410902V Modulates RecA activity (By similarity) CG477_002750 ENOG41067AE Membrane-bound metal-dependent hydrolase CG477_002755 ENOG4105CEN a g-specific adenine glycosylase CG477_002765 ENOG4106BXE CG477_002780 ENOG4105EVI UPF0374 protein CG477_002785 ENOG4105BZ1 (ABC) transporter CG477_002790 ENOG4107NBY Membrane CG477_002795 ENOG4105CBC glutamate synthase CG477_002800 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase CG477_002805 ENOG4108IUW ABC transporter CG477_002825 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CG477_002830 ENOG4105G5W regulator Fur family CG477_002930 ENOG4105GMB type VI secretion system effector, hcp1 family CG477_002955 ENOG4105CDY transcriptional regulatory protein CG477_002960 ENOG4108JQC penicillin-binding protein 1A CG477_002965 ENOG4107ZQN disulfide bond CG477_002975 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) CG477_002985 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CG477_002995 ENOG4105CYN Serine protein kinase CG477_003005 ENOG4106AKX UPF0229 protein CG477_003020 ENOG410829K Lysine exporter protein (Lyse ygga) CG477_003030 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CG477_003060 ENOG4105C94 Transporter CG477_003075 ENOG4105DZ6 Band 7 protein CG477_003120 ENOG4108MRH transcriptional regulatory protein CG477_003130 ENOG4105C6K Malic enzyme CG477_003145 ENOG4105BZU Histidine kinase CG477_003150 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CG477_003160 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CG477_003165 ENOG4108JB9 formate dehydrogenase CG477_003180 ENOG4105C8Q Methyl-accepting chemotaxis CG477_003190 ENOG4105CUB amino acid CG477_003210 ENOG4105C59 p-type ATPase CG477_003215 ENOG4105DAP Nicotinate phosphoribosyltransferase CG477_003240 ENOG4105C59 p-type ATPase CG477_003260 ENOG41073R8 VanW family CG477_003265 ENOG4108KGH TRANSCRIPTIONal CG477_003275 ENOG4105C37 (CBS) domain CG477_003280 ENOG4108IJ0 Aspartate ammonia-lyase CG477_003285 ENOG4105DAA L-lactate CG477_003305 ENOG4105DUX Transporter CG477_003315 ENOG4105EXW epimerase dehydratase CG477_003330 ENOG4107T89 von Willebrand factor, type A CG477_003335 ENOG4105GMT ATPase associated with various cellular activities aaa_5 CG477_003340 ENOG4105D5Q Arginine ornithine antiporter CG477_003345 ENOG4105CRN Aminoglycoside phosphotransferase CG477_003350 ENOG4105BZG amino acid carrier protein CG477_003360 ENOG4105CDA abc transporter atp-binding protein CG477_003365 ENOG4105CT1 (ABC) transporter CG477_003370 ENOG4105EAD ABC transporter CG477_003375 ENOG4105DRP amino acid AbC transporter CG477_003380 ENOG4108IQI permease CG477_003390 ENOG4105BZU Histidine kinase CG477_003395 ENOG4105E3W Two component transcriptional regulator (Winged helix family CG477_003405 ENOG4105CHH sulfate transporter CG477_003410 ENOG4107YZX Universal stress protein CG477_003420 ENOG4105DEF Extracellular solute-binding protein, family 5 CG477_003430 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CG477_003435 ENOG4108JQ7 (ABC) transporter CG477_003445 ENOG4105CXY transporter CG477_003450 ENOG41067TZ transcriptional regulator, MarR family CG477_003455 ENOG4105C0R drug resistance transporter emrb qaca subfamily CG477_003460 ENOG4105ETE Transcriptional regulator (LacI family CG477_003465 ENOG4108RVA ribokinase CG477_003470 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) CG477_003475 ENOG4105C2J ABC transporter CG477_003480 ENOG4105CNN ABC, transporter CG477_003485 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CG477_003490 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CG477_003550 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CG477_003555 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer CG477_003560 ENOG41069ER domain protein CG477_003565 ENOG4105VZ8 Transcriptional regulator CG477_003570 ENOG4107D63 CG477_003605 ENOG4105C85 amino acid CG477_003610 ENOG4105MA6 gCN5-related N-acetyltransferase CG477_003635 ENOG4105BZ9 Cytochrome C oxidase, subunit I CG477_003640 ENOG4105E2S oxidase) subunit II CG477_003665 ENOG4105E1V na solute symporter CG477_003680 ENOG4108NHD germination protein CG477_003690 ENOG4105CE1 Ferrous iron transport protein b CG477_003695 ENOG4105CE1 Ferrous iron transport protein b CG477_003700 ENOG4105CE1 Ferrous iron transport protein b CG477_003705 ENOG4105CVA phosphate CG477_003710 ENOG4105C8U phosphate abc transporter CG477_003715 ENOG4105E2Z phosphate ABC transporter (Permease CG477_003760 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CG477_003845 ENOG41080XQ Signal transduction protein with cbs domains CG477_003870 ENOG4105ETU transcriptional activator (TenA CG477_003880 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component CG477_003890 ENOG4108VEU Thiamine monophosphate synthase CG477_003895 ENOG41080HI glycine oxidase CG477_003905 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) CG477_003910 ENOG4105D06 uba thif-type nad fad binding protein CG477_003915 ENOG4105DWF phosphomethylpyrimidine kinase CG477_003945 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) CG477_003950 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) CG477_003960 ENOG4108FPN Integrase CG477_003975 ENOG4105E09 nadh pyrophosphatase CG477_003985 ENOG4105G5W regulator Fur family CG477_004010 ENOG4108INS Transcriptional regulator CG477_004020 ENOG4105C7N Xanthine uracil vitamin C permease CG477_004025 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CG477_004030 ENOG4108VZI ErfK ybiS ycfS ynhG family protein CG477_004045 ENOG4105K63 Thioredoxin CG477_004055 ENOG4108RCF TRANSCRIPTIONal CG477_004070 ENOG4108B31 Spore germination protein CG477_004085 ENOG4107Y03 Nitroreductase CG477_004095 ENOG4105ED1 spovr family CG477_004105 ENOG4108KGH TRANSCRIPTIONal CG477_004125 ENOG4107RBB ABC transporter, permease CG477_004130 ENOG4105C19 ABC transporter CG477_004145 ENOG4105WEF catalase CG477_004200 ENOG4107RWR Sodium hydrogen exchanger CG477_004205 ENOG4106KNT transcriptional regulator CG477_004215 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate CG477_004265 ENOG4108YXU transcriptional regulator AsnC family CG477_004280 ENOG4105D5Q Arginine ornithine antiporter CG477_004290 ENOG4105C26 Dehydrogenase CG477_004295 ENOG4105BZ1 (ABC) transporter CG477_004300 ENOG4105BZ1 (ABC) transporter CG477_004315 ENOG4105DRP amino acid AbC transporter CG477_004320 ENOG4105CDA abc transporter atp-binding protein CG477_004335 ENOG410839P CG477_004340 ENOG4106MP8 UPF0754 membrane protein CG477_004345 ENOG4105WZB UPF0342 protein CG477_004350 ENOG4105BZU Histidine kinase CG477_004355 ENOG4105WH1 Two component transcriptional regulator luxr family CG477_004415 ENOG4108VX5 3-methyladenine DNA glycosylase CG477_004430 ENOG4105D4P Coproporphyrinogen iii oxidase CG477_004435 ENOG4105CEY Amp-dependent synthetase and ligase CG477_004485 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein CG477_004490 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein CG477_004505 ENOG4105CGU Enoyl-CoA hydratase CG477_004520 ENOG4105DER m42 family CG477_004535 ENOG4105CJW magnesium transporter CG477_004540 ENOG4105CNI cell division protein FtsW CG477_004665 ENOG4107D63 CG477_004670 ENOG4105VZ8 Transcriptional regulator CG477_004715 ENOG4105CZV ABC transporter CG477_004760 ENOG4105M6F mutator MutT protein CG477_004775 ENOG4105CFI type iii restriction protein res subunit CG477_004785 ENOG4108JUB Transcriptional regulator CG477_004790 ENOG4105DVW rieske (2Fe-2S) CG477_004800 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CG477_004810 ENOG4105E1V na solute symporter CG477_004835 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme CG477_004855 ENOG4105C1B dTDP-glucose 4-6-dehydratase CG477_004865 ENOG4105FAW cDP-glucose 4,6-dehydratase CG477_004870 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase CG477_004895 ENOG4105CID antiterminator CG477_004900 ENOG4105C5Y PTS System CG477_004905 ENOG4105CS2 ec 3.2.1.21 CG477_004915 ENOG4105CMT Dihydroxyacetone kinase CG477_004920 ENOG4105K8R UPF0145 protein CG477_004950 ENOG4107VRP DNA repair exonuclease CG477_004955 ENOG4106D4I domain protein CG477_004960 ENOG4105EQI Metal Dependent Phosphohydrolase CG477_004975 ENOG4107WD8 ABC transporter, permease CG477_004985 ENOG4105BZU Histidine kinase CG477_004990 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CG477_005000 ENOG4108KGH TRANSCRIPTIONal CG477_005015 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator CG477_005025 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CG477_005030 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CG477_005035 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CG477_005065 ENOG4105K59 histidine triad (HIT) protein CG477_005095 ENOG410905X membrane-flanked domain protein CG477_005105 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation CG477_005110 ENOG4105BZ4 penicillin-binding protein CG477_005115 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) CG477_005125 ENOG4105C1Q protoporphyrinogen oxidase CG477_005180 ENOG4106AXD CG477_005185 ENOG4108RQ5 Beta-lactamase domain-containing protein CG477_005190 ENOG4105DF9 Lipoate-protein, ligase CG477_005200 ENOG4105CEY Amp-dependent synthetase and ligase CG477_005205 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) CG477_005220 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CG477_005240 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 CG477_005245 ENOG4105C8Q Methyl-accepting chemotaxis CG477_005265 ENOG4107QP3 malate synthase g CG477_005280 ENOG4105XVF Competence transcription factor CG477_005300 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation CG477_005340 ENOG4105ERH Fumarylacetoacetate hydrolase CG477_005360 ENOG4105CAQ asparagine synthetase CG477_005370 ENOG4105CH6 catalase CG477_005380 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) CG477_005385 ENOG4108VPT UPF0234 protein CG477_005390 ENOG4105QNR S1 RNA binding domain protein CG477_005395 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CG477_005405 ENOG4107AYK membrAne CG477_005420 ENOG4108KP7 hydrolase CG477_005435 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CG477_005460 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CG477_005465 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CG477_005480 ENOG4105C31 Tryptophanyl-tRNA synthetase CG477_005500 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CG477_005505 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CG477_005515 ENOG4108JQ7 (ABC) transporter CG477_005520 ENOG4105UQX Mate efflux family protein CG477_005550 ENOG4108ZCF integral membrane protein CG477_005560 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CG477_005570 ENOG4105DPN Oligoendopeptidase f CG477_005585 ENOG4108Z18 K06886 hemoglobin CG477_005590 ENOG4105MIX Adenylate cyclase CG477_005610 ENOG4105EMS pseudouridine synthase CG477_005620 ENOG4107S1Q Phosphatase CG477_005625 ENOG4105CNI cell division protein FtsW CG477_005670 ENOG4105K64 Glycosyl transferase, family 2 CG477_005690 ENOG4107TVC Glycosyl transferase, family 2 CG477_005710 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) CG477_005725 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase CG477_005750 ENOG4108WVJ 2'-5' rna ligase CG477_005775 ENOG4105CK7 Sodium proline symporter CG477_005835 ENOG4105C7S Dehydrogenase CG477_005840 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 CG477_005850 ENOG4106P55 Transcriptional regulator CG477_005855 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CG477_005860 ENOG4105C26 Dehydrogenase CG477_005875 ENOG4105DTN riboflavin biosynthesis protein ribF CG477_005890 ENOG4105ERH Fumarylacetoacetate hydrolase CG477_005970 ENOG4105EP9 oxidoreductase CG477_006000 ENOG4107JM4 Tetratricopeptide repeat CG477_006005 ENOG4105VTR Integrase CG477_006040 ENOG4105DZ1 carboxypeptidase CG477_006045 ENOG4105VFR signal peptidase CG477_006080 ENOG4105C26 Dehydrogenase CG477_006085 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CG477_006090 ENOG4105F38 ABC transporter, permease CG477_006095 ENOG4105D38 putrescine abc transporter CG477_006100 ENOG4107RUE extracellular solute-binding protein family 1 CG477_006105 ENOG4105YVM Phosphoesterase, PA-phosphatase related CG477_006110 ENOG4107R13 MMPL domain protein CG477_006120 ENOG4108YBP pseudouridine synthase CG477_006130 ENOG4105K4I Scp-like extracellular CG477_006135 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CG477_006140 ENOG4105CQB FAD linked oxidase domain protein CG477_006155 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CG477_006160 ENOG4105BZU Histidine kinase CG477_006165 ENOG4105JXH GntR family transcriptional regulator CG477_006170 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CG477_006175 ENOG4107QR9 Iron-sulfur cluster binding protein CG477_006180 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) CG477_006185 ENOG4106A3R peptidase CG477_006190 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CG477_006210 ENOG4105FQP Beta-lactamase CG477_006240 ENOG4108QTI )-transporter CG477_006245 ENOG4107TS3 membrane protein, TerC CG477_006250 ENOG4105CZN Potassium uptake protein CG477_006255 ENOG410681C small acid-soluble spore protein CG477_006260 ENOG4108Z7G MaoC domain protein dehydratase CG477_006280 ENOG4105CHR reductase CG477_006305 ENOG4105C4Y ABC transporter CG477_006310 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CG477_006315 ENOG4107RCV ABC transporter, permease CG477_006320 ENOG4108KAZ Involved in phosphonate degradation (By similarity) CG477_006325 ENOG4107STF Involved in phosphonate degradation (By similarity) CG477_006330 ENOG4105E98 transcriptional regulator DeoR family CG477_006335 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) CG477_006345 ENOG4105PXI polysaccharide deacetylase CG477_006360 ENOG4105BZU Histidine kinase CG477_006365 ENOG41090MY MarR family Transcriptional regulator CG477_006385 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) CG477_006390 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase CG477_006395 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) CG477_006400 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) CG477_006415 ENOG4108R6G acetyltransferase CG477_006435 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) CG477_006450 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CG477_006455 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family CG477_006460 ENOG4105CZV ABC transporter CG477_006470 ENOG4105CJ1 ABC, transporter CG477_006505 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A CG477_006510 ENOG4105EA8 2-Nitropropane dioxygenase CG477_006515 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD CG477_006525 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein CG477_006530 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) CG477_006545 ENOG4105NQC Flavodoxin CG477_006570 ENOG4105E0M Sulfatase CG477_006595 ENOG4105GPN Uncharacterized conserved protein (DUF2294) CG477_006600 ENOG4108TWJ NADH dehydrogenase subunit 5 CG477_006605 ENOG4105EVH UPF0753 protein CG477_006615 ENOG4107QMU Mate efflux family protein CG477_006645 ENOG4105CZN Potassium uptake protein CG477_006655 ENOG4105KBJ sporulation protein ytfj CG477_006670 ENOG4106AUC UPF0180 protein CG477_006680 ENOG4105C7K acetolactate synthase CG477_006685 ENOG4108ZP8 Acetolactate synthase small subunit CG477_006690 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CG477_006705 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CG477_006710 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CG477_006720 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) CG477_006730 ENOG4105ECC imidazole-glycerol-phosphate dehydratase CG477_006735 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CG477_006740 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase CG477_006745 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) CG477_006750 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase CG477_006755 ENOG41083RF phosphoribosyl-ATP pyrophosphatase CG477_006770 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase CG477_006775 ENOG4105E0M Sulfatase CG477_006800 ENOG4107RIQ Sulfate adenylate transferase CG477_006805 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) CG477_006810 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) CG477_006820 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CG477_006825 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein CG477_006830 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CG477_006835 ENOG4105C8J )-transporter CG477_006855 ENOG4105DFD Na H antiporter CG477_006875 ENOG4105ENE Histidine kinase CG477_006880 ENOG4105WH1 Two component transcriptional regulator luxr family CG477_006920 ENOG4105CID antiterminator CG477_006930 ENOG4105CS2 ec 3.2.1.21 CG477_006950 ENOG4105DM4 PTS System CG477_006955 ENOG4105DG6 mannose-6-phosphate isomerase CG477_006965 ENOG4105DQ6 Transposase CG477_006990 ENOG4105CJ3 phosphate transporter CG477_006995 ENOG4107GRR phosphate transport regulator CG477_007000 ENOG4105BZ4 penicillin-binding protein CG477_007010 ENOG4105BZU Histidine kinase CG477_007015 ENOG4105I3N Conserved Protein CG477_007030 ENOG4105BZU Histidine kinase CG477_007035 ENOG4105D3A purine nucleoside phosphorylase DeoD-type CG477_007060 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CG477_007065 ENOG4105DZ1 carboxypeptidase CG477_007070 ENOG4108JIC nucleoside recognition domain protein CG477_007080 ENOG4105FE9 pseudouridine synthase CG477_007090 ENOG4107TWT Cytochrome c biogenesis protein CG477_007095 ENOG4105CRE cytochrome C CG477_007100 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CG477_007105 ENOG4105BZU Histidine kinase CG477_007115 ENOG4108K5P (LipO)protein CG477_007125 ENOG4108SAX Membrane CG477_007140 ENOG4105C9U ATP-dependent DNA helicase RecQ CG477_007145 ENOG4105I7S Abortive infection protein CG477_007155 ENOG4107RGJ metallophosphoesterase CG477_007160 ENOG4107X2D transcriptional regulator, merr family CG477_007165 ENOG4108S6Z Negative regulator of genetic competence CG477_007185 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase CG477_007190 ENOG4105HDK L-asparaginase CG477_007200 ENOG4105CAT Cytidine monophosphate kinase CG477_007210 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) CG477_007225 ENOG4105S2F CG477_007230 ENOG41065D1 CG477_007235 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) CG477_007240 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase CG477_007260 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) CG477_007270 ENOG4105EUJ GTP cyclohydrolase i CG477_007275 ENOG4105XXQ heptaprenyl diphosphate synthase component I CG477_007280 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CG477_007285 ENOG4105EAH synthase CG477_007295 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CG477_007300 ENOG4105D49 3-dehydroquinate synthase CG477_007305 ENOG4105CIH Imidazole acetol-phosphate transaminase CG477_007310 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase CG477_007315 ENOG41068YB TPR repeat-containing protein CG477_007330 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) CG477_007335 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) CG477_007340 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit CG477_007370 ENOG4108JYZ YitT family CG477_007375 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase CG477_007380 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) CG477_007385 ENOG4108Z5K methylglyoxal synthase CG477_007390 ENOG4105FJR Lmbe family CG477_007395 ENOG4105CPK Glycosyl transferase (Group 1 CG477_007400 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate CG477_007415 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) CG477_007420 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) CG477_007425 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) CG477_007430 ENOG4105DVT helicase CG477_007435 ENOG4105YAC CG477_007455 ENOG4105CSM endonuclease III CG477_007465 ENOG4105BZ4 penicillin-binding protein CG477_007470 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) CG477_007505 ENOG4106F55 Protein of unknown function (DUF1273) CG477_007520 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) CG477_007530 ENOG4105DVT helicase CG477_007535 ENOG4105CTD carboxy-peptidase CG477_007540 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) CG477_007545 ENOG4105C2W permease CG477_007550 ENOG4105DHF Membrane CG477_007555 ENOG410890F Dynamin family CG477_007565 ENOG4108W0I acetyltransferase CG477_007575 ENOG4105KHC sulfurtransferase CG477_007610 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic CG477_007620 ENOG4105KVH Transcriptional regulator CG477_007640 ENOG41081VK Ribonuclease CG477_007690 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CG477_007695 ENOG4107RWR Sodium hydrogen exchanger CG477_007700 ENOG4105CN5 Metallo-Beta-Lactamase CG477_007725 ENOG4105H67 Protein of unknown function (DUF421) CG477_007730 ENOG41080C8 DUF218 domain CG477_007755 ENOG4107R0U MotA TolQ exbB proton channel CG477_007760 ENOG4106VK6 Flagellar motor protein CG477_007765 ENOG4107YTP response regulator receiver protein CG477_007770 ENOG4105CBS Chea signal transduction histidine kinase CG477_007775 ENOG4105DD5 Flagellar motor switch protein CG477_007790 ENOG4105BZU Histidine kinase CG477_007810 ENOG4105E1Q flagellar hook-associated protein CG477_007815 ENOG4105DTJ flagellar hook-associated protein CG477_007835 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) CG477_007840 ENOG4108ZC9 flagellar basal-body rod protein flgc CG477_007845 ENOG41075Z6 flagellar hook-basal body complex protein fliE CG477_007850 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) CG477_007855 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CG477_007885 ENOG4105BZE flagellar hook protein, FlgE CG477_007900 ENOG4107R88 Chemotaxis protein (CheV) CG477_007910 ENOG4105I03 Flagellin CG477_007915 ENOG4105I03 Flagellin CG477_007920 ENOG4105E4C Lytic transglycosylase catalytic CG477_007925 ENOG4105DD5 Flagellar motor switch protein CG477_007930 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CG477_007935 ENOG4105DD5 Flagellar motor switch protein CG477_007945 ENOG4105CN7 Flagellar biosynthetic protein FliP CG477_007950 ENOG4105VS8 Flagellar biosynthetic protein fliq CG477_007960 ENOG4105D00 flagellar biosynthetic protein flhB CG477_007965 ENOG4105D7B Flagellar biosynthesis protein flha CG477_007970 ENOG4105FZW flagellar biosynthesis regulator FlhF CG477_007975 ENOG4105KTQ flagellar basal-body rod protein CG477_007980 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CG477_008040 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr CG477_008075 ENOG4105CAQ asparagine synthetase CG477_008095 ENOG4105DRR Transcriptional regulator, GntR family CG477_008100 ENOG4108UZ3 Transporter CG477_008105 ENOG410751J CG477_008110 ENOG4105DFD Na H antiporter CG477_008120 ENOG4105C9Q fumarate hydratase class II CG477_008145 ENOG4107QJQ Mate efflux family protein CG477_008150 ENOG4105EC3 peptidase S51, dipeptidase E CG477_008155 ENOG4106BRA Membrane CG477_008170 ENOG4105C0D helicase CG477_008185 ENOG4105CU9 asparagine synthetase A CG477_008225 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CG477_008235 ENOG4108J59 Extracellular solute-binding protein, family 5 CG477_008240 ENOG4105EU0 Major facilitator Superfamily CG477_008245 ENOG4105C6T cysteine synthase CG477_008255 ENOG4105C8J )-transporter CG477_008260 ENOG4105X5K response regulator receiver protein CG477_008275 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CG477_008280 ENOG4105CM2 brancheD-chain amino acid aminotransferase CG477_008290 ENOG4105C01 Dihydroxy-acid dehydratase CG477_008295 ENOG4105C7B Threonine dehydratase CG477_008325 ENOG4105D06 uba thif-type nad fad binding protein CG477_008330 ENOG4105C6X Major Facilitator CG477_008335 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b CG477_008355 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) CG477_008370 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) CG477_008375 ENOG4105C72 UPF0176 protein CG477_008385 ENOG4106PZP Bacillus haemolytic enterotoxin (HBL) CG477_008395 ENOG4107RHR regulatoR CG477_008400 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) CG477_008425 ENOG4105TRT Transcriptional regulator CG477_008430 ENOG4105C26 Dehydrogenase CG477_008435 ENOG4108JB8 alcohol dehydrogenase CG477_008450 ENOG4105C26 Dehydrogenase CG477_008455 ENOG4108JPW Aminotransferase CG477_008465 ENOG4106F5Q Membrane CG477_008470 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CG477_008475 ENOG4105CKI cobalamin synthesis protein CG477_008505 ENOG4105W8Z 4'-phosphopantetheinyl transferase CG477_008530 ENOG4105D6E homoserine dehydrogenase CG477_008540 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) CG477_008550 ENOG4107VMI polysaccharide deacetylase CG477_008560 ENOG4105KT7 mgtC SapB transporter CG477_008565 ENOG4105VRR gCN5-related N-acetyltransferase CG477_008570 ENOG4105YWU small acid-soluble spore protein CG477_008600 ENOG4105C4K Nad synthetase CG477_008610 ENOG4105EYF MMPL domain protein CG477_008630 ENOG4105C8Q Methyl-accepting chemotaxis CG477_008645 ENOG4108K88 Membrane CG477_008650 ENOG4108WPJ Ferritin-like domain CG477_008670 ENOG4105CKI cobalamin synthesis protein CG477_008680 ENOG4105DSE periplasmic solute binding protein CG477_008695 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CG477_008700 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CG477_008715 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) CG477_008735 ENOG4107T5V SNARE associated Golgi CG477_008750 ENOG4108PJD permease CG477_008760 ENOG4108S4H thioesterase Superfamily protein CG477_008780 ENOG4105CHR reductase CG477_008790 ENOG4105SXS Protein of unknown function (DUF456) CG477_008795 ENOG4105C37 (CBS) domain CG477_008835 ENOG4108ZRV stage ii sporulation protein p CG477_008845 ENOG4108VXD carboxy-peptidase CG477_008895 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CG477_008900 ENOG41087PP glycosyltransferase MGT family CG477_008905 ENOG41087PP glycosyltransferase MGT family CG477_008910 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CG477_008960 ENOG4108MGT Required for secretion of EsxA and EsxB CG477_009015 ENOG4105KBJ sporulation protein ytfj CG477_009040 ENOG4107QNM Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) CG477_009065 ENOG4108V06 Glutathione peroxidase CG477_009100 ENOG41082YX Transcriptional regulator, arsr family CG477_009105 ENOG4105D6J arsenicaL-resistance protein CG477_009110 ENOG4107Z3C Arsenate Reductase CG477_009160 ENOG4105C5H ABC transporter CG477_009170 ENOG4108UUM single-stranded DNA-binding protein CG477_009190 ENOG4107YX5 Pfam:DUF548 CG477_009195 ENOG4105C75 arginyL-tRNA synthetase CG477_009205 ENOG4105C8J )-transporter CG477_009230 ENOG4105D06 uba thif-type nad fad binding protein CG477_009235 ENOG4105E8G Major facilitator Superfamily CG477_009255 ENOG4105CY2 Citrate transporter CG477_009265 ENOG4105KD7 acetyltransferase CG477_009270 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase CG477_009300 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) CG477_009305 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) CG477_009315 ENOG4107RVG penicillin-binding protein CG477_009320 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) CG477_009325 ENOG4105E9Q Acyl-transferase CG477_009330 ENOG4108UT2 hemolysin iii CG477_009340 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CG477_009350 ENOG4108RCR degv family CG477_009360 ENOG4108KF3 Electron transport protein SCO1 SenC CG477_009365 ENOG4107Y70 Heat shock protein CG477_009370 ENOG4105CAQ asparagine synthetase CG477_009385 ENOG4105F0I Aminotransferase CG477_009405 ENOG4107Y70 Heat shock protein CG477_009415 ENOG4106KNT transcriptional regulator CG477_009420 ENOG4105CMG Carbohydrate kinase CG477_009425 ENOG4105C6Z Gluconate CG477_009485 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) CG477_009495 ENOG4105C37 (CBS) domain CG477_009520 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CG477_009535 ENOG4107S4Y M20 DapE family protein YgeY CG477_009545 ENOG4108JUB Transcriptional regulator CG477_009555 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein CG477_009565 ENOG4106E6V UPF0346 protein CG477_009595 ENOG410841Q phosphoesterase PA-phosphatase related protein CG477_009605 ENOG4105SZ6 Thioredoxin CG477_009630 ENOG410682P Hypothetical protein (DUF2513) CG477_009650 ENOG4105JQZ Methyltransferase CG477_009675 ENOG4105H67 Protein of unknown function (DUF421) CG477_009680 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase CG477_009725 ENOG4105BZ4 penicillin-binding protein CG477_009740 ENOG4105DXD 2-methylcitrate dehydratase CG477_009745 ENOG4105CR4 methylisocitrate lyase CG477_009750 ENOG4105C1G acyl-Coa dehydrogenase CG477_009755 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CG477_009760 ENOG4105C26 Dehydrogenase CG477_009770 ENOG4105N14 lysine exporter protein LysE YggA CG477_009790 ENOG4107RFY SbcCD D subunit CG477_009795 ENOG4105EYH Exonuclease CG477_009800 ENOG4105DUX Transporter CG477_009855 ENOG4105DA5 (ABC) transporter CG477_009880 ENOG41090U3 tautomerase CG477_009950 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase CG477_009955 ENOG4105E4F Isochorismate synthase CG477_009960 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase CG477_009965 ENOG4105WQI isochorismatase CG477_009970 ENOG4105CEY Amp-dependent synthetase and ligase CG477_009975 ENOG4105WQT MbtH domain protein CG477_009980 ENOG4105C0R drug resistance transporter emrb qaca subfamily CG477_009995 ENOG4105K70 DNA-binding protein CG477_010015 ENOG4105C22 threonyL-tRNA synthetase CG477_010060 ENOG4105CPC Aldo Keto reductase CG477_010090 ENOG4105BZ1 (ABC) transporter CG477_010095 ENOG4105BZ1 (ABC) transporter CG477_010100 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CG477_010125 ENOG4105F32 YngK protein CG477_010145 ENOG4105RD7 BadF BadG BcrA BcrD CG477_010155 ENOG4105C1J atp-dependent rna helicase CG477_010165 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CG477_010190 ENOG41075D4 Aminoglycoside 6-adenylyltransferase CG477_010195 ENOG4105CIN aminoacyl-histidine dipeptidase CG477_010205 ENOG4105C1G acyl-Coa dehydrogenase CG477_010210 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CG477_010215 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit CG477_010220 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase CG477_010225 ENOG4105E39 Enoyl-CoA hydratase CG477_010230 ENOG4107QX3 carboxylase CG477_010235 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CG477_010245 ENOG4105K64 Glycosyl transferase, family 2 CG477_010250 ENOG4108ZHR arsR family transcriptional regulator CG477_010265 ENOG4105BZU Histidine kinase CG477_010275 ENOG4105T9C HD domain CG477_010295 ENOG4107TXC Transcriptional regulator CG477_010315 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) CG477_010325 ENOG4105CHR reductase CG477_010365 ENOG4108IG5 Transcriptional regulator CG477_010375 ENOG4105CHR reductase CG477_010380 ENOG4105KRN Transcriptional regulator, abrb family CG477_010400 ENOG4108V4B ThiJ pfpI CG477_010405 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CG477_010425 ENOG4107VFR oxidoreductase CG477_010430 ENOG4105PKS Excinuclease abc c subunit domain protein CG477_010440 ENOG4105KWG Pfam:DUF1696 CG477_010445 ENOG4108NRW Phospholipase, patatin family CG477_010465 ENOG4108Z4K mutator MutT protein CG477_010515 ENOG4105FCD Major Facilitator CG477_010565 ENOG4105K64 Glycosyl transferase, family 2 CG477_010580 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CG477_010585 ENOG4108ZUB Lysine exporter protein (Lyse ygga) CG477_010635 ENOG4105C7F AcnD-accessory protein PrpF CG477_010640 ENOG4105BZU Histidine kinase CG477_010645 ENOG410667J hydrolase CG477_010700 ENOG4107JM4 Tetratricopeptide repeat CG477_010710 ENOG4105WKZ CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) CG477_010720 ENOG4105E9M CRISPR-associated protein, Csn1 family CG477_010740 ENOG4105ETU transcriptional activator (TenA CG477_010745 ENOG4107RUZ Sss sodium solute transporter superfamily CG477_010765 ENOG4105MSI germination protein ypeb CG477_010795 ENOG4106IPI cyclase, family CG477_010800 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) CG477_010810 ENOG4105E1F short-chain dehydrogenase reductase CG477_010820 ENOG4107SQ8 Glycine betaine CG477_010825 ENOG4108IJ7 Glycine betaine CG477_010855 ENOG41082BV acetyltransferase CG477_010885 ENOG4105C9U ATP-dependent DNA helicase RecQ CG477_010910 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase CG477_010920 ENOG4108M1A Chitin-binding protein CG477_010930 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein CG477_010970 ENOG4105DTQ mandelate racemase muconate lactonizing CG477_011050 ENOG4105EPR degv family CG477_011100 ENOG4106BHF CG477_011230 ENOG4107BMA Transglycosylase associated protein CG477_011235 ENOG4105D7V transposase CG477_011260 ENOG4105CHM Aminotransferase CG477_011275 ENOG4105EEM helicase CG477_011280 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CG477_011305 ENOG4105C02 permease CG477_011320 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) CG477_011325 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CG477_011330 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein CG477_011335 ENOG4105D7T ABC transporter CG477_011345 ENOG4108AQF aminoglycoside N(3)-acetyltransferase CG477_011350 ENOG4105D7V transposase CG477_011360 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) CG477_011370 ENOG4107VMI polysaccharide deacetylase CG477_011375 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC CG477_011385 ENOG4106ETB IIa component CG477_011390 ENOG4105E0M Sulfatase CG477_011395 ENOG4105C5H ABC transporter CG477_011400 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase CG477_011420 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase CG477_011435 ENOG4105ZHF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) CG477_011465 ENOG4108QCZ crispr-associated cxxc_cxxc protein cst1 CG477_011475 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) CG477_011490 ENOG41068WN CG477_011515 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) CG477_011525 ENOG4105CMR udp-glucose 4-epimerase CG477_011530 ENOG4108XET gCN5-related N-acetyltransferase CG477_011535 ENOG4105CSH Transporter CG477_011550 ENOG4108PCN EamA-like transporter family CG477_011565 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) CG477_011580 ENOG410635A Membrane CG477_011590 ENOG4108IQI permease CG477_011615 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) CG477_011630 ENOG4105E7W lamb ycsf family protein CG477_011640 ENOG4105P4J Allophanate hydrolase, subunit 1 CG477_011645 ENOG4107258 Transcriptional regulator CG477_011655 ENOG4106N3A copper homeostasis protein cutc CG477_011660 ENOG4105FDT acyl-CoA dehydrogenase CG477_011675 ENOG4105DWD nucleoside recognition domain protein CG477_011710 ENOG4108IAJ Nad-dependent epimerase dehydratase CG477_011715 ENOG4107SBE Glycosyl transferase (Group 1 CG477_011735 ENOG4107SBE Glycosyl transferase (Group 1 CG477_011740 ENOG4108KS4 Spore coat protein CG477_011750 ENOG4108JQ1 Dehydrogenase CG477_011755 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) CG477_011895 ENOG4108ISG Major Facilitator CG477_011910 ENOG4107MII Sugar-specific transcriptional regulator TrmB CG477_011915 ENOG4105CZM Major Facilitator CG477_011925 ENOG4105CRW Short chain fatty acid transporter CG477_011960 ENOG4108JJB ABC transporter CG477_011985 ENOG4108Z66 YbaK ebsC protein CG477_012000 ENOG4105CJ1 ABC, transporter CG477_012060 ENOG4105FTQ Dna gyrase CG477_012070 ENOG4105DWT malate dehydrogenase (quinone) CG477_012075 ENOG4108U5N UPF0316 protein CG477_012085 ENOG4105C37 (CBS) domain CG477_012095 ENOG4105XDF Protein of unknown function (DUF1272) CG477_012215 ENOG4105D60 lipoprotein releasing system transmembrane protein CG477_012220 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CG477_012285 ENOG4105H3G oxidoreductase CG477_012305 ENOG4108TN2 lmbE family CG477_012315 ENOG4107R3E Citrate transporter CG477_012330 ENOG4105C98 muts2 protein CG477_012335 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase CG477_012340 ENOG4105DPN Oligoendopeptidase f CG477_012360 ENOG4107VXM glycerophosphoryl diester phosphodiesterase CG477_012365 ENOG4105D9U N-acetyltransferase CG477_012375 ENOG4107SDU Methyl-accepting chemotaxis CG477_012395 ENOG4108M1A Chitin-binding protein CG477_012405 ENOG4105CNG UPF0061 protein CG477_012410 ENOG4105CQB FAD linked oxidase domain protein CG477_012415 ENOG4105KT7 mgtC SapB transporter CG477_012420 ENOG41073R8 VanW family CG477_012430 ENOG4108R1P CG477_012620 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) CG477_012775 ENOG4105VTR Integrase CG477_012800 ENOG4105VEQ Cold shock protein CG477_012810 ENOG410904N short-chain dehydrogenase reductase CG477_012815 ENOG4106IQC argininosuccinate lyase CG477_012830 ENOG4105ESF Peptidoglycan binding domain protein CG477_012845 ENOG4108IA2 Sodium pantothenate symporter CG477_012855 ENOG4105C26 Dehydrogenase CG477_012865 ENOG4105EWU Squalene--hopene cyclase CG477_012875 ENOG4105FR1 rard protein CG477_012925 ENOG4107QJT sodium dicarboxylate symporter CG477_012930 ENOG4105D9R oxidoreductase CG477_012940 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CG477_012950 ENOG4105K4P CoA-binding domain protein CG477_012955 ENOG4105C0H protease CG477_012960 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CG477_012970 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase CG477_012975 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CG477_012980 ENOG4105W8X HesB YadR YfhF-family protein CG477_013015 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CG477_013020 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CG477_013025 ENOG4105VMP Transcriptional regulator CG477_013045 ENOG4108I0Z Aconitate hydratase CG477_013050 ENOG410746C Acid-soluble spore protein O CG477_013085 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CG477_013090 ENOG4105CEY Amp-dependent synthetase and ligase CG477_013195 ENOG4105F9F transposase CG477_013210 ENOG4105UQX Mate efflux family protein CG477_013250 ENOG4107AYK membrAne CG477_013260 ENOG4105BZU Histidine kinase CG477_013265 ENOG4105CK7 Sodium proline symporter CG477_013270 ENOG4108903 Formimidoylglutamase CG477_013275 ENOG4105CI2 imidazolone-5-propionate hydrolase CG477_013280 ENOG4105CGP Urocanate hydratase CG477_013290 ENOG4105U7G Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization (By similarity) CG477_013310 ENOG4107QIV Cytochrome c biogenesis protein CG477_013325 ENOG4107RSM transcriptional regulator CG477_013330 ENOG4105VAW lrga family CG477_013335 ENOG41067MG lrgb family CG477_013370 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CG477_013385 ENOG4105BZ1 (ABC) transporter CG477_013390 ENOG4105BZ1 (ABC) transporter CG477_013430 ENOG4105CGH 5'-nucleotidase CG477_013440 ENOG4108SVB resolvase CG477_013445 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) CG477_013460 ENOG4105K7K Transcriptional regulator CG477_013495 ENOG4105D5G Transposase CG477_013500 ENOG4105D5G Transposase CG477_013505 ENOG4105D5G Transposase CG477_013520 ENOG4105FQP Beta-lactamase CG477_013545 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CG477_013565 ENOG4107TSN permease CG477_013620 ENOG410682Q Phage transcriptional regulator, ArpU CG477_013690 ENOG4108PNI recT protein CG477_013735 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) CG477_013740 ENOG4105C5F glutamine synthetase CG477_013745 ENOG4105KV4 Transcriptional regulator CG477_013750 ENOG4105CXI aluminum resistance protein CG477_013755 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CG477_013760 ENOG4105EN6 Membrane CG477_013765 ENOG4106F1P AAA ATPase, central domain protein CG477_013780 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CG477_013785 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) CG477_013795 ENOG41069ER domain protein CG477_013800 ENOG4105DM4 PTS System CG477_013805 ENOG4105DE4 1-phosphofructokinase CG477_013810 ENOG4105E98 transcriptional regulator DeoR family CG477_013815 ENOG4108SJC Membrane CG477_013840 ENOG4105TMB Formate nitrite transporter CG477_013845 ENOG4105K70 DNA-binding protein CG477_013850 ENOG4105VPX protein, conserved in bacteria CG477_013855 ENOG4105NIV Esterase CG477_013860 ENOG4105E0A ABC, transporter CG477_013880 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) CG477_013885 ENOG4105F9F transposase CG477_013890 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CG477_013900 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase CG477_013940 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) CG477_013945 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) CG477_013960 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CG477_013965 ENOG4105DQU oxidoreductase, subunit beta CG477_013970 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein CG477_013975 ENOG4108IGT Dipeptidase CG477_013980 ENOG4105MCT stage V sporulation protein S CG477_013985 ENOG4105D48 metallophosphoesterase CG477_013990 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) CG477_013995 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) CG477_014000 ENOG4105CEV competence damage-inducible protein CG477_014005 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CG477_014020 ENOG4105XZV Protein of unknown function (DUF3243) CG477_014025 ENOG4108RKS Short-chain dehydrogenase reductase Sdr CG477_014045 ENOG4105UIB (ABC) transporter CG477_014050 ENOG4108JQ9 ABC transporter CG477_014055 ENOG4105DIH basic membrane CG477_014060 ENOG4105FDP GntR family transcriptional regulator CG477_014065 ENOG4105CNU cell division protein FtsK CG477_014080 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit CG477_014115 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CG477_014125 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CG477_014130 ENOG4108S0H Dipicolinic acid synthetase, b subunit CG477_014135 ENOG4105E35 Dipicolinate synthase subunit A CG477_014145 ENOG4105C1V Peptidase, M16 CG477_014155 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) CG477_014165 ENOG4105DTN riboflavin biosynthesis protein ribF CG477_014170 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) CG477_014175 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) CG477_014180 ENOG4105W7A Protein of unknown function (DUF503) CG477_014185 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) CG477_014190 ENOG4105VHM ribosomal protein CG477_014195 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination CG477_014200 ENOG4105CHV Transcription elongation factor NusA CG477_014205 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) CG477_014210 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CG477_014215 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) CG477_014220 ENOG4105DZP Membrane-associated zinc metalloprotease CG477_014230 ENOG4105KNE Phosphatidate cytidylyltransferase CG477_014235 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CG477_014240 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) CG477_014250 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) CG477_014255 ENOG4105CE9 30S ribosomal protein S2 CG477_014265 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) CG477_014270 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) CG477_014275 ENOG4108HE4 integrase family CG477_014280 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) CG477_014285 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CG477_014290 ENOG4105C79 DNA protecting protein DprA CG477_014295 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha CG477_014300 ENOG4105CMV Succinyl-CoA synthetase subunit beta CG477_014305 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CG477_014310 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) CG477_014320 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) CG477_014325 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) CG477_014330 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) CG477_014335 ENOG4105VB6 UPF0109 protein CG477_014340 ENOG4105K5M 30s ribosomal protein S16 CG477_014350 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) CG477_014355 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CG477_014360 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) CG477_014365 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) CG477_014375 ENOG4105CHR reductase CG477_014380 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CG477_014385 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) CG477_014390 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) CG477_014395 ENOG4105CB5 ATP-dependent DNA helicase recG CG477_014400 ENOG4105DP4 dak2 domain fusion protein ylov CG477_014405 ENOG4108ZAA Alkaline-shock protein CG477_014410 ENOG4107JIY 50S ribosomal protein l28 CG477_014420 ENOG4105FJ0 thiamine CG477_014425 ENOG4105DJV ribulose-phosphate 3-epimerase CG477_014430 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CG477_014435 ENOG4105D9P serine threonine protein kinase CG477_014440 ENOG4108ZF3 Phosphatase CG477_014445 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs CG477_014450 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CG477_014455 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) CG477_014460 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CG477_014465 ENOG4105C25 Primosomal protein n' CG477_014470 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase CG477_014490 ENOG4105DSJ YicC domain protein CG477_014500 ENOG4105F23 Fibronectin-binding protein CG477_014520 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) CG477_014525 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) CG477_014530 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) CG477_014535 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) CG477_014540 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain CG477_014550 ENOG4105CD3 dihydroorotase CG477_014555 ENOG4105CXT aspartate transcarbamylase CG477_014565 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) CG477_014575 ENOG4105C34 Pseudouridine synthase CG477_014580 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) CG477_014590 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CG477_014600 ENOG4105DBK s4 domain protein CG477_014605 ENOG41067XK integral membrane protein CG477_014610 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) CG477_014615 ENOG4105DFA alanine racemase domain protein CG477_014620 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CG477_014625 ENOG4105WR5 sporulation protein, YlmC YmxH family CG477_014635 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CG477_014645 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CG477_014650 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CG477_014655 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) CG477_014665 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CG477_014670 ENOG4105CNI cell division protein FtsW CG477_014675 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) CG477_014685 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CG477_014690 ENOG4105CJN penicillin-binding protein CG477_014695 ENOG4105CJN penicillin-binding protein CG477_014700 ENOG41068DC Essential cell division protein (By similarity) CG477_014705 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) CG477_014710 ENOG41074B2 UPF0747 protein CG477_014735 ENOG4105KNH Nucleic acid-binding protein CG477_014770 ENOG410907Z n-acetylmuramoyl-l-alanine amidase CG477_014845 ENOG4105CAR Terminase, large subunit CG477_014935 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) CG477_014965 ENOG4108PNI recT protein CG477_014975 ENOG4108NF7 phage-type endonuclease CG477_015020 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) CG477_015030 ENOG41063PX domain protein CG477_015035 ENOG4105D78 K07001 NTE family protein CG477_015040 ENOG4105H20 Sporulation integral membrane protein YlbJ CG477_015045 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) CG477_015050 ENOG4106H78 methyltransferase CG477_015060 ENOG4105WUC UPF0298 protein CG477_015070 ENOG4107TB6 phosphoglycerate mutase CG477_015085 ENOG4106UY4 Inherit from COG: Scp-like extracellular CG477_015130 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) CG477_015140 ENOG4105CNI cell division protein FtsW CG477_015145 ENOG4105ZPI UPF0358 protein CG477_015155 ENOG4108IAB Phoh family CG477_015175 ENOG4105QA2 CG477_015180 ENOG4105CI3 gtp-binding protein typa CG477_015190 ENOG4105ECY inositol monophosphatase CG477_015205 ENOG4105WBI UPF0223 protein CG477_015210 ENOG4105CXN decarboxylase CG477_015250 ENOG4105C7S Dehydrogenase CG477_015270 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CG477_015275 ENOG4108X4Q Hydrolase CG477_015285 ENOG4106EHS UPF0356 protein CG477_015290 ENOG4105CN5 Metallo-Beta-Lactamase CG477_015295 ENOG4107ZYR domain protein CG477_015305 ENOG4105CH2 amidohydrolase CG477_015310 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) CG477_015330 ENOG4108XRC Protein of unknown function (DUF458) CG477_015350 ENOG4107IN1 Protein of unknown function (DUF1797) CG477_015365 ENOG4105EPM Diguanylate phosphodiesterase CG477_015370 ENOG4105K6S Short-chain dehydrogenase reductase Sdr CG477_015385 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) CG477_015395 ENOG4105UIN CG477_015430 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) CG477_015450 ENOG4108HGU Histidine kinase CG477_015460 ENOG4105CHM Aminotransferase CG477_015465 ENOG4105FKQ transcriptional regulator CG477_015470 ENOG4105EG2 ABC transporter, permease CG477_015480 ENOG4107FKK extracellular solute-binding protein family 1 CG477_015495 ENOG4105CG3 alpha amylase, catalytic region CG477_015530 ENOG4105CHU acetyl-coa acetyltransferase CG477_015560 ENOG4105K7K Transcriptional regulator CG477_015565 ENOG4105DTD Dehydrogenase CG477_015580 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) CG477_015585 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase CG477_015595 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate CG477_015600 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) CG477_015610 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) CG477_015625 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CG477_015655 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) CG477_015670 ENOG4105CID antiterminator CG477_015680 ENOG4105FDP GntR family transcriptional regulator CG477_015685 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) CG477_015690 ENOG4105CE4 GlcNAc 6-P deacetylase CG477_015700 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) CG477_015705 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) CG477_015725 ENOG4107ZE5 PPIases accelerate the folding of proteins CG477_015730 ENOG4105PTM secreted protein CG477_015735 ENOG4105DQF Hydrolase CG477_015745 ENOG4105G6R Stage v sporulation protein ae CG477_015755 ENOG4105CZ3 stage V sporulation protein ad CG477_015760 ENOG41090VF Stage v sporulation protein ac CG477_015780 ENOG4105C8J )-transporter CG477_015785 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CG477_015790 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) CG477_015795 ENOG41082AN stage II sporulation protein CG477_015800 ENOG4105DZ1 carboxypeptidase CG477_015810 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family CG477_015815 ENOG4105DVE abc transporter atp-binding protein CG477_015855 ENOG4105D7N magnesium and cobalt transport protein CorA CG477_015885 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CG477_015895 ENOG4105I3K Ferric uptake regulator, Fur family CG477_015900 ENOG4105MZ9 stage II sporulation protein m CG477_015920 ENOG4105CPC Aldo Keto reductase CG477_015930 ENOG4105RHY Pfam:UPF0157 CG477_015950 ENOG4107SKW Inherit from COG: Alpha beta hydrolase CG477_015960 ENOG4105ETE Transcriptional regulator (LacI family CG477_015965 ENOG4108YM7 Gcn5-related n-acetyltransferase CG477_015985 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CG477_015990 ENOG4108R6K riboflavin synthase, subunit alpha CG477_015995 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CG477_016010 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) CG477_016015 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CG477_016020 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) CG477_016025 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CG477_016035 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CG477_016045 ENOG4105DFD Na H antiporter CG477_016050 ENOG4105CGH 5'-nucleotidase CG477_016075 ENOG4107RRU Involved in both the arginine and lysine biosynthetic pathways (By similarity) CG477_016085 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase CG477_016095 ENOG4108IXY short-chain dehydrogenase reductase CG477_016100 ENOG41069FQ Metallo-beta-lactamase superfamily CG477_016105 ENOG4105II7 pyrroline-5-carboxylate reductase CG477_016110 ENOG4105EJQ L-serine dehydratase CG477_016125 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) CG477_016145 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CG477_016150 ENOG4105D9U N-acetyltransferase CG477_016165 ENOG4108VZI ErfK ybiS ycfS ynhG family protein CG477_016170 ENOG4108QEG Membrane CG477_016175 ENOG4105CDA abc transporter atp-binding protein CG477_016180 ENOG4105E5Q amino acid AbC transporter CG477_016185 ENOG4108HW3 (ABC) transporter CG477_016195 ENOG4105G7B Protein of unknown function (DUF2992) CG477_016200 ENOG4105E09 nadh pyrophosphatase CG477_016215 ENOG4105C7S Dehydrogenase CG477_016220 ENOG4105CPP Dehydrogenase, E1 component CG477_016235 ENOG4105CKM Branched-chain carboxylic acid kinase CG477_016240 ENOG4107RDP Dehydrogenase CG477_016255 ENOG4108JUB Transcriptional regulator CG477_016260 ENOG4106CCJ Protein of unknown function (DUF2627) CG477_016265 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CG477_016275 ENOG4107QQR Sporulation CG477_016280 ENOG4105S1Z Stage IV sporulation protein B CG477_016285 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CG477_016295 ENOG4105DX0 Hemolysin A CG477_016300 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) CG477_016315 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CG477_016320 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) CG477_016325 ENOG4105M7K Involved in the transcription termination process (By similarity) CG477_016330 ENOG4108ZSR alkaline shock protein CG477_016335 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CG477_016360 ENOG410644B Stage III sporulation protein af CG477_016370 ENOG4105KQ4 Stage iii sporulation protein ad CG477_016375 ENOG4108CQH stage III sporulation protein AC CG477_016380 ENOG4105KR5 Stage iii sporulation protein CG477_016385 ENOG4105CD2 stage iii sporulation protein aa CG477_016405 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) CG477_016410 ENOG4105DC7 peptidase M24 CG477_016415 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) CG477_016425 ENOG4105CBJ Metal-dependent enzyme CG477_016445 ENOG41082GG biotin lipoate A B protein ligase CG477_016450 ENOG4105WZW rhodanese family CG477_016475 ENOG41080TC multidrug resistance protein CG477_016500 ENOG4105DVE abc transporter atp-binding protein CG477_016505 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family CG477_016520 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CG477_016525 ENOG4108JEM The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CG477_016530 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) CG477_016535 ENOG4105C0D helicase CG477_016565 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) CG477_016615 ENOG4105XSJ toxin secretion phage lysis holin CG477_016700 ENOG41061CV Terminase small subunit CG477_016710 ENOG410682Q Phage transcriptional regulator, ArpU CG477_016775 ENOG4106CVF DNA replication protein CG477_016790 ENOG4108PNI recT protein CG477_016795 ENOG4108NF7 phage-type endonuclease CG477_016820 ENOG4108IMY Transcriptional regulator CG477_016830 ENOG4108C33 Resolvase CG477_016870 ENOG4107TVP HD domain protein CG477_016885 ENOG4105C3R Methionine synthase CG477_016895 ENOG4105C28 cystathionine CG477_016900 ENOG4105C28 cystathionine CG477_016920 ENOG4105C5X domain protein CG477_016930 ENOG4105DKQ ROK family CG477_016940 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase CG477_016945 ENOG4105WDJ 50S ribosomal protein L33 CG477_016955 ENOG4108UTW Plays a role in the regulation of phosphate uptake CG477_016960 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CG477_016965 ENOG4105E2Z phosphate ABC transporter (Permease CG477_016970 ENOG4105C8U phosphate abc transporter CG477_016980 ENOG4107RF6 penicillin-binding protein CG477_016990 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CG477_017010 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) CG477_017015 ENOG4105N80 Ferric uptake regulator, Fur family CG477_017025 ENOG4105FDK ABC transporter CG477_017030 ENOG4108JYZ YitT family CG477_017040 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) CG477_017055 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) CG477_017060 ENOG4105EGD dinuclear metal center protein, YbgI family CG477_017075 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CG477_017080 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CG477_017085 ENOG4107XJU UPF0178 protein CG477_017090 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) CG477_017100 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) CG477_017110 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) CG477_017120 ENOG4107YR5 Diacylglycerol kinase CG477_017125 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) CG477_017130 ENOG4105CTJ Metal Dependent Phosphohydrolase CG477_017135 ENOG4105C9A Phoh family CG477_017145 ENOG41068P3 sporulation protein YqfC CG477_017150 ENOG4105KTH gatB Yqey CG477_017155 ENOG41084BG 30S ribosomal protein S21 CG477_017160 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CG477_017165 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CG477_017170 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) CG477_017175 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) CG477_017180 ENOG4105CFG Acts as a chaperone (By similarity) CG477_017185 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ CG477_017190 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) CG477_017195 ENOG4105CSA Coproporphyrinogen iii oxidase CG477_017200 ENOG4105KVH Transcriptional regulator CG477_017205 ENOG4108Z0Z intracellular protease Pfpi family CG477_017210 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) CG477_017225 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) CG477_017230 ENOG4105TQK DNA polymerase iii, delta' subunit CG477_017240 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 CG477_017245 ENOG4108UK2 deaminase CG477_017250 ENOG4105KQC Competence protein CG477_017260 ENOG4105DXX methyltransferase CG477_017270 ENOG4108WF2 Metal Dependent Phosphohydrolase CG477_017275 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) CG477_017280 ENOG410812S Rna-binding protein CG477_017285 ENOG4105E2X shikimate dehydrogenase CG477_017290 ENOG4105CQW ribosome biogenesis GTPase YqeH CG477_017295 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase CG477_017305 ENOG4105DJ4 phosphatidylserine decarboxylase CG477_017310 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CG477_017320 ENOG4105WDJ 50S ribosomal protein L33 CG477_017330 ENOG4105G6Z alkaline phosphatase CG477_017335 ENOG4105KEG ribosomal-protein-alanine acetyltransferase CG477_017340 ENOG4108MUZ hydrolase CG477_017365 ENOG4105MIR Phenylalanine 4-monooxygenase CG477_017370 ENOG4105KZX Pterin carbinolamine dehydratase CG477_017375 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase CG477_017405 ENOG4105C28 cystathionine CG477_017415 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) CG477_017420 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) CG477_017435 ENOG4107XRG penicillin-binding protein CG477_017445 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) CG477_017455 ENOG4105CFP Peptidase U32 CG477_017460 ENOG4105XYU peptidase (U32 family) CG477_017465 ENOG4108VQJ O-methyltransferase CG477_017470 ENOG4105HHA aminodeoxychorismate lyase CG477_017480 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) CG477_017485 ENOG4105VBH UPF0297 protein CG477_017490 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CG477_017495 ENOG4105C02 permease CG477_017510 ENOG41060CR CG477_017515 ENOG4105C7H Helicase, RecD TraA family CG477_017525 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) CG477_017530 ENOG4105C3J Cysteine desulfurase CG477_017540 ENOG4105D1H recombination factor protein RarA CG477_017560 ENOG41075H3 AraC family transcriptional regulator CG477_017565 ENOG4108VCI transcription factor, rsfa family CG477_017570 ENOG4105CUZ uba thif-type nad fad binding protein CG477_017575 ENOG4105C9M aspartyl-trna synthetase CG477_017580 ENOG4105CUT histidyl-tRNA synthetase CG477_017600 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) CG477_017605 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CG477_017610 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) CG477_017615 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CG477_017620 ENOG41076HS cation diffusion facilitator family transporter CG477_017625 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CG477_017635 ENOG4105CKP Polysaccharide Biosynthesis Protein CG477_017650 ENOG4107EXU Short-chain dehydrogenase reductase Sdr CG477_017660 ENOG4105VIE preprotein translocase, subunit YajC CG477_017665 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) CG477_017670 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) CG477_017675 ENOG41061AI Protein of unknown function (DUF2905) CG477_017680 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) CG477_017685 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) CG477_017690 ENOG4108HUF Transporter CG477_017710 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) CG477_017715 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase CG477_017720 ENOG4108IYU L-aspartate oxidase CG477_017735 ENOG4108RPX mosc domain containing protein CG477_017740 ENOG4105CQC Prephenate dehydratase CG477_017760 ENOG4105EWM Histidine kinase CG477_017780 ENOG4105K46 50S ribosomal protein l27 CG477_017785 ENOG4105X36 (ribosomal) protein CG477_017795 ENOG4105C03 ribonuclease CG477_017810 ENOG4107QMS site-determining protein CG477_017815 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) CG477_017825 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) CG477_017830 ENOG4105DFF Rod shape-determining protein mreb CG477_017850 ENOG4108Z03 MAF-like protein CG477_017860 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CG477_017885 ENOG41068KH stage VI sporulation protein D CG477_017885 ENOG41068KH stage VI sporulation protein D CG477_017890 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase CG477_017895 ENOG4105D52 delta-aminolevulinic acid dehydratase CG477_017905 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) CG477_017915 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) CG477_017920 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) CG477_017930 ENOG4108IUQ atp-dependent protease CG477_017935 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) CG477_017940 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CG477_017955 ENOG4105W8Z 4'-phosphopantetheinyl transferase CG477_017960 ENOG4108JA1 polyketide synthase CG477_017965 ENOG4105C0W non-ribosomal peptide synthetase CG477_017980 ENOG4105EYF MMPL domain protein CG477_017990 ENOG4105KBX Transcriptional regulator, TetR family CG477_018050 ENOG4105M59 Phosphodiesterase, mj0936 family CG477_018060 ENOG4108FK2 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) CG477_018065 ENOG4108XJQ germination protein CG477_018075 ENOG4105PFC Transcriptional regulator CG477_018085 ENOG4108Z40 Transcriptional regulator CG477_018090 ENOG4105RHA ABC transporter, permease CG477_018095 ENOG4108IUX (ABC) transporter CG477_018100 ENOG4105ER2 Ompa motb domain protein CG477_018105 ENOG4105E14 MotA TolQ exbB proton channel CG477_018115 ENOG4108VXD carboxy-peptidase CG477_018125 ENOG4105E33 succinate dehydrogenase CG477_018135 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit CG477_018155 ENOG4105K63 Thioredoxin CG477_018160 ENOG4105C10 Electron transfer flavoprotein CG477_018165 ENOG4105BZJ Electron transfer flavoprotein CG477_018170 ENOG41060WC Enoyl-CoA hydratase CG477_018175 ENOG4107Z3H Transcriptional regulator, TetR family CG477_018180 ENOG4105CEY Amp-dependent synthetase and ligase CG477_018220 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CG477_018235 ENOG4105DR4 Methyltransferase CG477_018245 ENOG4105FE9 pseudouridine synthase CG477_018255 ENOG4105C98 muts2 protein CG477_018260 ENOG4105DCG PHP domain protein CG477_018270 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) CG477_018275 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CG477_018295 ENOG4105C5S asparaginyl-tRNA synthetase CG477_018300 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) CG477_018305 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) CG477_018310 ENOG4108RWN rrna methyltransferase CG477_018335 ENOG4105C0R drug resistance transporter emrb qaca subfamily CG477_018340 ENOG4105CW7 secretion protein, HlyD family CG477_018345 ENOG4108JGH Tetr family transcriptional regulator CG477_018350 ENOG4105CN9 Peptidase m42 family protein CG477_018360 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) CG477_018365 ENOG4105VJV 50s ribosomal protein L35 CG477_018370 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) CG477_018375 ENOG4105C22 threonyL-tRNA synthetase CG477_018380 ENOG4108TDW sporulation protein YtxC CG477_018395 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) CG477_018400 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) CG477_018410 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CG477_018430 ENOG4105C2M dna polymerase I CG477_018435 ENOG4105BZU Histidine kinase CG477_018440 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CG477_018450 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CG477_018455 ENOG4108HMX isocitrate dehydrogenase (NADP) CG477_018460 ENOG4105BZN citrate synthase CG477_018465 ENOG4108VMM UPF0756 membrane protein CG477_018470 ENOG4108REF Sporulation integral membrane protein ytvi CG477_018475 ENOG4105FS0 cytoplasmic membrane protein CG477_018485 ENOG4105CTQ phosphohexokinase CG477_018490 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) CG477_018495 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) CG477_018500 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family CG477_018505 ENOG4105C6K Malic enzyme CG477_018510 ENOG4105C0B DNA polymerase III (alpha subunit) CG477_018515 ENOG4105VV2 CG477_018525 ENOG4105SFS phosphoesterase RecJ domain protein CG477_018540 ENOG4105E8R UPF0173 metal-dependent hydrolase CG477_018545 ENOG4105DC7 peptidase M24 CG477_018575 ENOG4107YZX Universal stress protein CG477_018600 ENOG4105CH7 arginosuccinase CG477_018605 ENOG4105CDH Citrulline--aspartate ligase CG477_018615 ENOG4108JYZ YitT family CG477_018625 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) CG477_018635 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) CG477_018640 ENOG4105KBJ sporulation protein ytfj CG477_018655 ENOG4105EFZ amidohydrolase CG477_018660 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CG477_018670 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) CG477_018680 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) CG477_018685 ENOG4105RQF LysR family Transcriptional regulator CG477_018695 ENOG4105U5Y Transcriptional regulator CG477_018705 ENOG4105C28 cystathionine CG477_018715 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) CG477_018740 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CG477_018755 ENOG4105F1V Acetoin utilization protein CG477_018760 ENOG4105W87 Cbs domain CG477_018765 ENOG4105DGU Histone deacetylase CG477_018770 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) CG477_018780 ENOG4105ETE Transcriptional regulator (LacI family CG477_018790 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase CG477_018805 ENOG4105C88 aminopeptidase CG477_018820 ENOG4105DFU Cell wall formation (By similarity) CG477_018840 ENOG4108VDD TRNA binding domain protein CG477_018845 ENOG4108NKM UPF0354 protein CG477_018885 ENOG4105C8F Beta-lactamase domain protein CG477_018890 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) CG477_018900 ENOG4108V15 phosphotransferase enzyme family CG477_018905 ENOG4108IUM Glycogen debranching enzyme CG477_018915 ENOG4107QSE Dipeptidase CG477_018920 ENOG4105YW5 deoR family transcriptional regulator CG477_018935 ENOG4105CBX hi0933 family CG477_018970 ENOG4108VJ1 Transcriptional regulator (CarD family CG477_018990 ENOG4108ZAF Molybdopterin CG477_018995 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein CG477_019000 ENOG4105CVM Molybdenum cofactor synthesis domain protein CG477_019005 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CG477_019010 ENOG4105D06 uba thif-type nad fad binding protein CG477_019015 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CG477_019020 ENOG4107V6Q Cyclic nucleotide-binding domain CG477_019030 ENOG4108IUE nitrate reductase beta subunit CG477_019035 ENOG4105R3A Nitrate reductase CG477_019055 ENOG41085GJ domain protein CG477_019065 ENOG4105DWV Homoserine O-trans-acetylase CG477_019100 ENOG4105C8T Leucyl-tRNA synthetase CG477_019105 ENOG410605W Major Facilitator CG477_019115 ENOG4105C19 ABC transporter CG477_019120 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily CG477_019135 ENOG4105N5T Radical SAM Protein CG477_019145 ENOG4105FDK ABC transporter CG477_019165 ENOG4105D29 Helix-turn-helix type 11 domain protein CG477_019175 ENOG4105E8V Alpha Beta Hydrolase Fold protein CG477_019180 ENOG4108Z0R Transferase CG477_019190 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) CG477_019195 ENOG4105EPU Molybdenum cofactor synthesis domain protein CG477_019215 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP CG477_019225 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase CG477_019275 ENOG4108UHU Aldolase CG477_019280 ENOG4107EFN gluconate transport system permease 3 CG477_019285 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) CG477_019290 ENOG4105DEI Mannitol dehydrogenase CG477_019295 ENOG4107HP6 Transcriptional regulator CG477_019300 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CG477_019310 ENOG4107T7U Sulfatase CG477_019325 ENOG4105D2X ABC transporter substrate-binding protein CG477_019335 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component CG477_019365 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) CG477_019370 ENOG4108V2W Carbonate dehydratase CG477_019375 ENOG4105C4M (Ubiquinol oxidase) subunit I CG477_019380 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CG477_019410 ENOG41087YS Phage shock protein A CG477_019450 ENOG4108UGV hypoxanthine phosphoribosyltransferase CG477_019455 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) CG477_019460 ENOG4105C19 ABC transporter CG477_019505 ENOG4105DTQ mandelate racemase muconate lactonizing CG477_019515 ENOG4108IPT Naphthoate synthase CG477_019520 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) CG477_019525 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) CG477_019530 ENOG4105E4F Isochorismate synthase CG477_019535 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CG477_019545 ENOG4105VEQ Cold shock protein CG477_019570 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) CG477_019580 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) CG477_019590 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CG477_019685 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CG477_019720 ENOG4105KT7 mgtC SapB transporter CG477_019725 ENOG4107PBV potassium channel CG477_019735 ENOG4107QYV phosphohexose isomerase CG477_019745 ENOG4105WG9 Conserved Protein CG477_019755 ENOG4105CHM Aminotransferase CG477_019760 ENOG4108ZB6 transcriptional regulator AsnC family CG477_019765 ENOG4105C5I Dehydrogenase CG477_019770 ENOG4108MUZ hydrolase CG477_019780 ENOG4105C87 Aminotransferase class I and II CG477_019785 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CG477_019790 ENOG4105Y38 Kinase-associated protein B CG477_019800 ENOG4107R3E Citrate transporter CG477_019805 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) CG477_019825 ENOG4105KA0 thioesterase Superfamily protein CG477_019840 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CG477_019855 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) CG477_019865 ENOG41069ER domain protein CG477_019885 ENOG4105CEP NADH dehydrogenase CG477_019905 ENOG4105EWC Purine nucleoside phosphorylase CG477_019940 ENOG4108M15 ABC transporter CG477_019965 ENOG4108YX9 iron--sulfur cluster insertion protein erpA CG477_019970 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) CG477_019990 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA CG477_020000 ENOG4105VMP Transcriptional regulator CG477_020020 ENOG41083MR nifu domain-containing protein CG477_020030 ENOG4108W5N phosphatidylglycerophosphatase a CG477_020035 ENOG4105D4U had-superfamily hydrolase, subfamily iia CG477_020050 ENOG4105CBT Fructose-1,6-bisphosphatase CG477_020060 ENOG4105MMD transcriptional regulator CG477_020070 ENOG4107TXC Transcriptional regulator CG477_020075 ENOG41090T1 Membrane CG477_020090 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) CG477_020095 ENOG4105FAA peptidase M23 CG477_020100 ENOG4108YTE sporulation protein YunB CG477_020105 ENOG4105KZD Domain of unknown function (DUF1805) CG477_020110 ENOG4107R8B 5'-nucleotidase CG477_020130 ENOG4105DIW FeS assembly protein SUFB CG477_020135 ENOG4108UNV SUF system FeS assembly protein, NifU family CG477_020140 ENOG4105C9B Cysteine desulfurase CG477_020145 ENOG4105JRK feS assembly protein SufD CG477_020150 ENOG4105C3K feS assembly ATPase SufC CG477_020155 ENOG4105D01 (LipO)protein CG477_020160 ENOG4108UMI ABC transporter, permease CG477_020190 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) CG477_020195 ENOG41080E8 Transcriptional regulator, Spx MgsR family CG477_020235 ENOG4105C1G acyl-Coa dehydrogenase CG477_020240 ENOG4105CHU acetyl-coa acetyltransferase CG477_020255 ENOG4105DZ1 carboxypeptidase CG477_020285 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer CG477_020305 ENOG4107R7I amino acid CG477_020310 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CG477_020320 ENOG4107AYK membrAne CG477_020330 ENOG4107ZTW SNARE associated Golgi CG477_020340 ENOG4108PXI ErfK YbiS YcfS YnhG CG477_020345 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CG477_020350 ENOG4105BZU Histidine kinase CG477_020355 ENOG4105C8Q Methyl-accepting chemotaxis CG477_020360 ENOG4105C8Q Methyl-accepting chemotaxis CG477_020365 ENOG4105VG1 fes assembly suf system protein CG477_020370 ENOG4105D4Y metalloprotease CG477_020390 ENOG4108RMU ferritin dps family protein CG477_020395 ENOG4108URH decarboxylase CG477_020420 ENOG4105DSE periplasmic solute binding protein CG477_020425 ENOG4105CC5 ABC transporter CG477_020430 ENOG4105DIK (ABC) transporter CG477_020450 ENOG4105D9N nucleoside CG477_020455 ENOG4105D9N nucleoside CG477_020465 ENOG4108RYK Nad-dependent epimerase dehydratase CG477_020495 ENOG4105WMR Protein CrcB homolog CG477_020510 ENOG4108Z7R Chaperone CsaA CG477_020515 ENOG4105E7U AraC family transcriptional regulator CG477_020520 ENOG4108VY7 phosphate-starvation-inducible protein PsiE CG477_020540 ENOG4108Q5U germination protein, ger(x)c family CG477_020545 ENOG4105E1K spore germination protein CG477_020560 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) CG477_020565 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CG477_020575 ENOG4105XZU Preprotein translocase, subunit SecG CG477_020580 ENOG41067MG lrgb family CG477_020590 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) CG477_020595 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CG477_020600 ENOG4105CP7 Triose-phosphate isomerase CG477_020605 ENOG4105BZA Phosphoglycerate kinase CG477_020625 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CG477_020670 ENOG41090VF Stage v sporulation protein ac CG477_020675 ENOG4105CZ3 stage V sporulation protein ad CG477_020690 ENOG4108QY0 Membrane CG477_020695 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CG477_020700 ENOG4105KRI phosphocarrier protein (HPr CG477_020705 ENOG4105CIE May be required for sporulation (By similarity) CG477_020710 ENOG4105CHW UPF0052 protein CG477_020715 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) CG477_020720 ENOG4108Z4K mutator MutT protein CG477_020730 ENOG4105C3M thioredoxin reductase CG477_020740 ENOG4108S4C acetyltransferase CG477_020750 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) CG477_020755 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) CG477_020760 ENOG41086DT Membrane protein of unknown function CG477_020770 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CG477_020785 ENOG4107SWG transcriptional regulator MERR family CG477_020805 ENOG4105DUM transcriptional regulator, lysR family CG477_020825 ENOG4105CN1 protease CG477_020830 ENOG4105CRP Part of the ABC transporter FtsEX involved in CG477_020835 ENOG4105CAK Cell division ATP-binding protein ftsE CG477_020870 ENOG4105VEQ Cold shock protein CG477_020875 ENOG41081UC Inherit from COG: Competence protein CG477_020890 ENOG4105KVH Transcriptional regulator CG477_020900 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CG477_020905 ENOG4108KGH TRANSCRIPTIONal CG477_020915 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CG477_020925 ENOG4105ESV Glycosyl transferase, family 4 CG477_020935 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CG477_020950 ENOG4105F8D glycoside hydrolase family 4 CG477_020955 ENOG4105VCP PTS System CG477_020970 ENOG4105VCP PTS System CG477_021000 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) CG477_021005 ENOG4105DAA L-lactate CG477_021010 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) CG477_021020 ENOG4105E0M Sulfatase CG477_021045 ENOG4107R8N Glycosyl transferase, family 2 CG477_021055 ENOG4105C94 Transporter CG477_021060 ENOG41069ER domain protein CG477_021075 ENOG4105KBK Zinc finger, swim domain protein CG477_021080 ENOG4105C0D helicase CG477_021120 ENOG4107RBB ABC transporter, permease CG477_021125 ENOG4105C19 ABC transporter CG477_021145 ENOG4105CXY transporter CG477_021160 ENOG41062D9 Histidine kinase CG477_021165 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CG477_021175 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) CG477_021185 ENOG4107VDP teichoic acid biosynthesis CG477_021190 ENOG4105EY8 ABC transporter CG477_021200 ENOG4107SJB teichoic acid biosynthesis CG477_021205 ENOG4107SJB teichoic acid biosynthesis CG477_021210 ENOG4107RZX Teichoic acid biosynthesis protein CG477_021215 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase CG477_021230 ENOG4105MT0 Sporulation transcriptional regulator spoiiid CG477_021240 ENOG4105FRN stage II sporulation protein CG477_021255 ENOG4105DY9 regulatoR CG477_021275 ENOG4106778 Protein of unknown function (DUF1146) CG477_021280 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CG477_021285 ENOG4105C8S subunit m CG477_021290 ENOG4105D65 subunit l CG477_021295 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CG477_021310 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) CG477_021315 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CG477_021320 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CG477_021325 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CG477_021330 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CG477_021335 ENOG4105BZU Histidine kinase CG477_021340 ENOG4105BZU Histidine kinase CG477_021355 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) CG477_021360 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) CG477_021370 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) CG477_021375 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) CG477_021380 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CG477_021385 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) CG477_021390 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CG477_021400 ENOG41062M3 atp synthase CG477_021415 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) CG477_021420 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) CG477_021430 ENOG4108YZG isomerase CG477_021455 ENOG4108VGI doxx family CG477_021460 ENOG4107XC4 flavin reductase domain protein, FMN-binding CG477_021475 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CG477_021485 ENOG4108ZXQ stage ii sporulation protein r CG477_021490 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CG477_021495 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) CG477_021500 ENOG4107104 thymidine kinase CG477_021510 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) CG477_021515 ENOG4105CBT Fructose-1,6-bisphosphatase CG477_021520 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CG477_021540 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) CG477_021555 ENOG4105C1G acyl-Coa dehydrogenase CG477_021560 ENOG4105C1G acyl-Coa dehydrogenase CG477_021565 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CG477_021575 ENOG4105DF6 Fe-S oxidoreductase CG477_021600 ENOG4105BZU Histidine kinase CG477_021605 ENOG4105KCT ABC transporter CG477_021610 ENOG4108M15 ABC transporter CG477_021615 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) CG477_021620 ENOG4105IIU Aminopeptidase CG477_021635 ENOG410684U Domain of unknown function (DUF1934) CG477_021655 ENOG4105CYW agmatinase CG477_021660 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) CG477_021665 ENOG4105DXB Major Facilitator superfamily CG477_021670 ENOG4107SWG transcriptional regulator MERR family CG477_021675 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CG477_021680 ENOG4105BZ4 penicillin-binding protein CG477_021685 ENOG4108XFG YwhD family CG477_021690 ENOG4108Z4T Peptidase M50 CG477_021695 ENOG41069HH 4-oxalocrotonate tautomerase CG477_021700 ENOG4105DCI Phosphohydrolase CG477_021705 ENOG4108MES Periplasmic binding protein CG477_021710 ENOG4105E0A ABC, transporter CG477_021715 ENOG4105EHG Permease protein CG477_021720 ENOG4105DQ5 transport system permease protein CG477_021730 ENOG4108VCI transcription factor, rsfa family CG477_021735 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) CG477_021740 ENOG4108IJ2 phosphate acetyltransferase CG477_021745 ENOG4107JTW chlorite dismutase CG477_021755 ENOG4108VKI Cell wall hydrolase CG477_021765 ENOG4105M08 Membrane CG477_021775 ENOG4107SVH Potassium channel protein CG477_021785 ENOG410667J hydrolase CG477_021790 ENOG4105VCH membrane CG477_021795 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) CG477_021800 ENOG4108TU7 Inherit from COG: (ABC) transporter CG477_021805 ENOG4105CJ1 ABC, transporter CG477_021810 ENOG41090WU lipolytic protein G-D-S-L family CG477_021815 ENOG4105D6E homoserine dehydrogenase CG477_021820 ENOG4105CVG Homoserine O-transsuccinylase CG477_021830 ENOG4105K8R UPF0145 protein CG477_021835 ENOG4105DWF phosphomethylpyrimidine kinase CG477_021845 ENOG4105D22 carbon starvation protein CG477_021850 ENOG4105DY9 regulatoR CG477_021855 ENOG41079KZ Major Facilitator Superfamily CG477_021870 ENOG4105CG5 Glycosyl transferase (Group 1 CG477_021880 ENOG4105EN6 Membrane CG477_021885 ENOG4106YBV Methyl-accepting chemotaxis CG477_021900 ENOG4108S4H thioesterase Superfamily protein CG477_021905 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) CG477_021920 ENOG4105K64 Glycosyl transferase, family 2 CG477_021935 ENOG4105CKK Glycosyl transferase, family 2 CG477_021940 ENOG4105C5H ABC transporter CG477_021945 ENOG41067SE Tetr family transcriptional regulator CG477_021955 ENOG4105E0X reductase CG477_021960 ENOG4106F5Q Membrane CG477_021965 ENOG41067MG lrgb family CG477_021975 ENOG4105DY9 regulatoR CG477_021980 ENOG4108HRK Histidine kinase CG477_021985 ENOG4107RGD Major Facilitator superfamily CG477_021995 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CG477_022005 ENOG4105CMR udp-glucose 4-epimerase CG477_022080 ENOG4105BZ1 (ABC) transporter CG477_022090 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) CG477_022100 ENOG4105C0H protease CG477_022105 ENOG4105Q2H domain protein CG477_022120 ENOG4105BZU Histidine kinase CG477_022125 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CG477_022150 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis CG477_022155 ENOG4105CDU Replicative dna helicase CG477_022160 ENOG41082B8 Binds to the 23S rRNA (By similarity) CG477_022165 ENOG4105BZR domain protein CG477_022170 ENOG4108XMW Membrane CG477_022175 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) CG477_022180 ENOG4108UUM single-stranded DNA-binding protein CG477_022185 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) CG477_022190 ENOG4105C3G gtp-binding protein CG477_022195 ENOG4105VDK protein, conserved in bacteria CG477_022200 ENOG4105D8X mechanosensitive ion channel CG477_022205 ENOG4108ZDA Sporulation protein YyaC CG477_022210 ENOG4105FA0 parb-like partition protein CG477_022215 ENOG4107QJE Chromosome Partitioning Protein CG477_022220 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) CG477_022225 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) CG477_022230 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) CG477_022235 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) CG477_022245 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CG477_022250 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) CG477_022270 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CG477_022290 ENOG4105W5Q DNA repair protein (RadC CG477_022470 ENOG4106A7E Transcriptional regulator CG477_022475 ENOG4108VB1 regulatoR CG477_022650 ENOG4105K4H Nlp p60 protein CG477_022800 ENOG4107QJE Chromosome Partitioning Protein CG477_022850 ENOG4108J59 Extracellular solute-binding protein, family 5 CG477_022885 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CG477_022965 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CG477_022980 ENOG4105DUM transcriptional regulator, lysR family CG477_023000 ENOG4105CHR reductase