locus-tag	class	description
CG477_000005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CG477_000010	COG0592	DNA-directed DNA polymerase activity
CG477_000015	COG2501	S4 domain
CG477_000020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CG477_000025	COG0187	DNA topoisomerase II activity
CG477_000030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CG477_000065	COG0517	IMP dehydrogenase activity
CG477_000065	COG0516	GMP reductase activity
CG477_000070	COG1686	Belongs to the peptidase S11 family
CG477_000075	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CG477_000080	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CG477_000085	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CG477_000100	COG1428	Deoxynucleoside kinase
CG477_000105	COG1428	Deoxynucleoside kinase
CG477_000110	COG1335	isochorismatase
CG477_000115	COG0590	tRNA wobble adenosine to inosine editing
CG477_000125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CG477_000130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CG477_000135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CG477_000180	COG1982	Orn Lys Arg decarboxylase major
CG477_000185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CG477_000190	COG0470	DNA polymerase III
CG477_000195	COG1774	PSP1 C-terminal conserved region
CG477_000200	COG4467	Involved in initiation control of chromosome replication
CG477_000205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CG477_000215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CG477_000220	COG2002	toxin-antitoxin pair type II binding
CG477_000230	COG0084	hydrolase, TatD family'
CG477_000240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CG477_000250	COG4466	Protein conserved in bacteria
CG477_000260	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CG477_000265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CG477_000270	COG0251	oxidation-reduction process
CG477_000275	COG2088	sporulation resulting in formation of a cellular spore
CG477_000280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CG477_000285	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CG477_000290	COG0193	aminoacyl-tRNA hydrolase activity
CG477_000300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CG477_000305	COG2002	toxin-antitoxin pair type II binding
CG477_000310	COG2244	polysaccharide biosynthetic process
CG477_000315	COG3956	TIGRFAM MazG family protein
CG477_000320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CG477_000340	COG1098	S1 RNA binding domain
CG477_000355	COG2208	phosphoserine phosphatase activity
CG477_000370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CG477_000375	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CG477_000380	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CG477_000385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CG477_000390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CG477_000395	COG0512	Glutamine amidotransferase of anthranilate synthase
CG477_000400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CG477_000405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CG477_000410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CG477_000415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CG477_000420	COG1396	sequence-specific DNA binding
CG477_000425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CG477_000430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CG477_000465	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG477_000515	COG3880	PFAM UvrB UvrC protein
CG477_000520	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CG477_000525	COG0542	response to heat
CG477_000530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CG477_000540	COG4956	integral membrane protein (PIN domain superfamily)
CG477_000545	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CG477_000550	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CG477_000555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CG477_000560	COG1045	serine acetyltransferase
CG477_000565	COG0215	cysteine-tRNA ligase activity
CG477_000575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CG477_000580	COG3688	RNA-binding protein containing a PIN domain
CG477_000600	COG0250	Participates in transcription elongation, termination and antitermination
CG477_000610	COG0081	regulation of translation
CG477_000615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CG477_000620	COG0222	ribosome binding
CG477_000625	COG2813	Specifically methylates the guanine in position
CG477_000635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CG477_000640	COG1358	cellular component organization or biogenesis
CG477_000645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CG477_000650	COG0049	tRNA binding
CG477_000655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CG477_000660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CG477_000670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CG477_000675	COG0088	Forms part of the polypeptide exit tunnel
CG477_000680	COG0089	rRNA binding
CG477_000685	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CG477_000690	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CG477_000695	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CG477_000700	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CG477_000705	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CG477_000715	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CG477_000720	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CG477_000725	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CG477_000730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CG477_000740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CG477_000745	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CG477_000750	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CG477_000755	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CG477_000760	COG1841	ribosomal large subunit assembly
CG477_000765	COG0200	Binds to the 23S rRNA
CG477_000770	COG0201	protein transport
CG477_000775	COG0563	adenylate kinase activity
CG477_000780	COG0024	Methionine aminopeptidase
CG477_000790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CG477_000800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CG477_000805	COG0202	RNA polymerase activity
CG477_000820	COG1122	ATPase activity
CG477_000825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CG477_000835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CG477_000840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CG477_000850	COG0860	N-Acetylmuramoyl-L-alanine amidase
CG477_000855	COG0489	protein tyrosine kinase activity
CG477_000865	COG2194	sulfuric ester hydrolase activity
CG477_000870	COG0726	polysaccharide deacetylase
CG477_000900	COG4974	Belongs to the 'phage' integrase family
CG477_001055	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CG477_001065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CG477_001105	COG1396	sequence-specific DNA binding
CG477_001110	COG0602	queuosine metabolic process
CG477_001220	COG3681	Belongs to the UPF0597 family
CG477_001225	COG3681	Belongs to the UPF0597 family
CG477_001250	COG2814	Major facilitator Superfamily
CG477_001260	COG0601	transmembrane transport
CG477_001265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CG477_001270	COG0444	Belongs to the ABC transporter superfamily
CG477_001275	COG4608	Belongs to the ABC transporter superfamily
CG477_001280	COG4166	transmembrane transport
CG477_001290	COG2207	Transcriptional regulator
CG477_001300	COG1309	transcriptional regulator
CG477_001310	COG0656	L-ascorbic acid biosynthetic process
CG477_001315	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CG477_001325	COG4149	molybdate abc transporter
CG477_001330	COG0725	ABC transporter, periplasmic molybdate-binding protein
CG477_001335	COG1910	domain protein
CG477_001340	COG0204	Acyl-transferase
CG477_001345	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG477_001350	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CG477_001350	COG1648	precorrin-2 dehydrogenase activity
CG477_001360	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CG477_001360	COG1587	Uroporphyrinogen-III synthase
CG477_001365	COG2146	nitrite reductase [NAD(P)H] activity
CG477_001370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CG477_001400	COG4585	Histidine kinase
CG477_001405	COG2197	response regulator
CG477_001410	COG1131	(ABC) transporter
CG477_001415	COG1511	domain protein
CG477_001415	COG0842	Transport permease protein
CG477_001420	COG0842	Transport permease protein
CG477_001430	COG0747	negative chemotaxis
CG477_001435	COG0601	transmembrane transport
CG477_001440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CG477_001445	COG0444	Belongs to the ABC transporter superfamily
CG477_001450	COG4608	Belongs to the ABC transporter superfamily
CG477_001455	COG0561	phosphatase activity
CG477_001475	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CG477_001480	COG0179	Fumarylacetoacetate (FAA) hydrolase
CG477_001490	COG2814	Major facilitator Superfamily
CG477_001495	COG1181	Belongs to the D-alanine--D-alanine ligase family
CG477_001500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CG477_001510	COG0705	Rhomboid family
CG477_001510	COG0457	Tetratricopeptide repeat
CG477_001515	COG0736	holo-[acyl-carrier-protein] synthase activity
CG477_001520	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CG477_001530	COG0864	Transcriptional regulator
CG477_001535	COG2337	Toxic component of a toxin-antitoxin (TA) module
CG477_001540	COG2183	response to ionizing radiation
CG477_001550	COG3091	SprT-like family
CG477_001590	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG477_001640	COG0802	atpase or kinase
CG477_001645	COG1214	PFAM Peptidase M22, glycoprotease
CG477_001650	COG0456	acetyltransferase
CG477_001660	COG0488	(ABC) transporter
CG477_001665	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CG477_001675	COG1266	CAAX protease self-immunity
CG477_001680	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CG477_001685	COG0459	protein refolding
CG477_001690	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CG477_001690	COG0519	Catalyzes the synthesis of GMP from XMP
CG477_001695	COG2252	PERMEase
CG477_001705	COG5002	protein histidine kinase activity
CG477_001775	COG2205	protein histidine kinase activity
CG477_001780	COG0745	RESPONSE REGULATOR receiver
CG477_001800	COG0697	spore germination
CG477_001825	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CG477_001830	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CG477_001835	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CG477_001840	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CG477_001845	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CG477_001850	COG0047	phosphoribosylformylglycinamidine synthase activity
CG477_001855	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CG477_001860	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CG477_001865	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CG477_001870	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CG477_001875	COG0138	bifunctional purine biosynthesis protein purh
CG477_001880	COG0151	Belongs to the GarS family
CG477_001890	COG0583	DNA-binding transcription factor activity
CG477_001910	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CG477_001915	COG0210	DNA helicase
CG477_001920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CG477_001925	COG4851	CamS sex pheromone cAM373 precursor
CG477_001935	COG1012	belongs to the aldehyde dehydrogenase family
CG477_001940	COG1335	isochorismatase
CG477_001950	COG2011	ABC-type metal ion transport system permease component
CG477_001955	COG1464	Belongs to the NlpA lipoprotein family
CG477_001970	COG4682	membrane
CG477_001975	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CG477_001980	COG0154	amidase activity
CG477_001985	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CG477_001990	COG1597	lipid kinase activity
CG477_001995	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CG477_002000	COG0546	phosphoglycolate phosphatase activity
CG477_002005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CG477_002015	COG0531	amino acid
CG477_002020	COG1012	belongs to the aldehyde dehydrogenase family
CG477_002025	COG2076	Multidrug Resistance protein
CG477_002030	COG2309	aminopeptidase activity
CG477_002045	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG477_002050	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CG477_002055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CG477_002070	COG0450	alkyl hydroperoxide reductase
CG477_002095	COG0714	Associated with various cellular activities
CG477_002130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG477_002135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG477_002140	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG477_002145	COG0492	ferredoxin-NADP+ reductase activity
CG477_002155	COG0166	Belongs to the GPI family
CG477_002160	COG5002	protein histidine kinase activity
CG477_002185	COG3541	Predicted nucleotidyltransferase
CG477_002190	COG2814	Major facilitator Superfamily
CG477_002195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CG477_002195	COG0723	plastoquinol--plastocyanin reductase activity
CG477_002205	COG0765	amino acid transport
CG477_002210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG477_002215	COG1126	abc transporter atp-binding protein
CG477_002220	COG0840	transmembrane signaling receptor activity
CG477_002235	COG2235	arginine
CG477_002250	COG0549	Belongs to the carbamate kinase family
CG477_002265	COG0366	Alpha amylase catalytic
CG477_002270	COG2190	(PTS) system
CG477_002270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG477_002270	COG1263	PTS System
CG477_002290	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG477_002295	COG4605	iron ion homeostasis
CG477_002300	COG4604	ABC transporter, ATP-binding protein
CG477_002305	COG4607	ABC-type enterochelin transport system periplasmic component
CG477_002310	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CG477_002315	COG0352	thiamine-phosphate diphosphorylase activity
CG477_002320	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CG477_002340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG477_002350	COG1116	anion transmembrane transporter activity
CG477_002430	COG2963	transposase activity
CG477_002435	COG2801	Transposase and inactivated derivatives
CG477_002440	COG2270	Major facilitator Superfamily
CG477_002465	COG2310	stress, protein
CG477_002470	COG2310	stress, protein
CG477_002475	COG2310	stress, protein
CG477_002480	COG0861	Integral membrane protein TerC family
CG477_002490	COG3853	Toxic anion resistance protein (TelA)
CG477_002500	COG4840	Belongs to the UPF0435 family
CG477_002505	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CG477_002515	COG1295	ribonuclease BN
CG477_002520	COG2217	Heavy metal translocating P-type atpase
CG477_002525	COG0697	spore germination
CG477_002535	COG0681	Belongs to the peptidase S26 family
CG477_002545	COG0586	Pfam SNARE associated Golgi protein
CG477_002560	COG0387	Pfam Sodium calcium exchanger
CG477_002570	COG0535	radical SAM domain protein
CG477_002590	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CG477_002615	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CG477_002640	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CG477_002670	COG2066	Belongs to the glutaminase family
CG477_002675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG477_002675	COG1263	PTS System
CG477_002680	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG477_002690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CG477_002690	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CG477_002700	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CG477_002705	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CG477_002720	COG0402	S-adenosylhomocysteine deaminase activity
CG477_002725	COG2137	regulation of response to DNA damage stimulus
CG477_002750	COG1988	membrane-bound metal-dependent
CG477_002755	COG1194	a g-specific adenine glycosylase
CG477_002780	COG3557	Belongs to the UPF0374 family
CG477_002785	COG1132	(ABC) transporter
CG477_002790	COG4129	membrane
CG477_002795	COG0067	glutamate synthase
CG477_002795	COG0069	glutamate synthase activity
CG477_002795	COG0070	glutamate synthase
CG477_002800	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CG477_002805	COG4555	ABC transporter
CG477_002825	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CG477_002830	COG0735	belongs to the Fur family
CG477_002930	COG3157	Type VI secretion system effector, Hcp
CG477_002950	COG0457	Tetratricopeptide repeat
CG477_002955	COG0217	transcriptional regulatory protein
CG477_002960	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CG477_002965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CG477_002985	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CG477_002995	COG2766	serine protein kinase
CG477_003020	COG1280	lysine exporter protein (LysE YggA)
CG477_003060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CG477_003070	COG1585	Membrane protein implicated in regulation of membrane protease activity
CG477_003075	COG2268	Band 7 protein
CG477_003105	COG4990	cell redox homeostasis
CG477_003115	COG3290	protein histidine kinase activity
CG477_003120	COG4565	transcriptional regulatory protein
CG477_003125	COG3493	citrate carrier protein
CG477_003130	COG0281	malic enzyme
CG477_003145	COG5002	protein histidine kinase activity
CG477_003150	COG0745	RESPONSE REGULATOR receiver
CG477_003160	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CG477_003165	COG3383	formate dehydrogenase (NAD+) activity
CG477_003170	COG2427	Protein of unknown function (DUF1641)
CG477_003180	COG0840	transmembrane signaling receptor activity
CG477_003190	COG0531	amino acid
CG477_003205	COG0640	Transcriptional regulator
CG477_003210	COG2217	Heavy metal translocating P-type atpase
CG477_003215	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CG477_003225	COG3227	Zinc metalloprotease (Elastase)
CG477_003240	COG2217	Heavy metal translocating P-type atpase
CG477_003260	COG2720	vancomycin resistance protein
CG477_003265	COG1316	TRANSCRIPTIONal
CG477_003275	COG1253	flavin adenine dinucleotide binding
CG477_003280	COG1027	Aspartate ammonia-lyase
CG477_003285	COG1620	l-lactate permease
CG477_003305	COG3104	oligopeptide transport
CG477_003310	COG0156	8-amino-7-oxononanoate synthase activity
CG477_003315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CG477_003330	COG4548	von Willebrand factor, type A
CG477_003335	COG0714	Associated with various cellular activities
CG477_003340	COG0531	amino acid
CG477_003345	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG477_003350	COG1115	amino acid carrier protein
CG477_003360	COG1126	abc transporter atp-binding protein
CG477_003365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG477_003370	COG0765	amino acid transport
CG477_003375	COG0765	amino acid transport
CG477_003380	COG0833	amino acid
CG477_003390	COG5002	protein histidine kinase activity
CG477_003395	COG0745	RESPONSE REGULATOR receiver
CG477_003405	COG0659	secondary active sulfate transmembrane transporter activity
CG477_003410	COG0589	response to stress
CG477_003420	COG0747	negative chemotaxis
CG477_003430	COG0601	transmembrane transport
CG477_003435	COG4608	Belongs to the ABC transporter superfamily
CG477_003445	COG2271	Major facilitator Superfamily
CG477_003450	COG1846	Transcriptional regulator
CG477_003455	COG0477	Major facilitator Superfamily
CG477_003460	COG1609	Transcriptional regulator
CG477_003465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CG477_003470	COG1869	D-ribose catabolic process
CG477_003475	COG1129	ABC transporter
CG477_003480	COG1172	Belongs to the binding-protein-dependent transport system permease family
CG477_003485	COG1879	ABC-type sugar transport system periplasmic component
CG477_003490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CG477_003530	COG3568	Endonuclease Exonuclease Phosphatase
CG477_003555	COG0840	transmembrane signaling receptor activity
CG477_003560	COG3583	domain protein
CG477_003560	COG3584	3D domain protein
CG477_003565	COG1476	TRANSCRIPTIONal
CG477_003595	COG1114	Component of the transport system for branched-chain amino acids
CG477_003605	COG1113	amino acid transport
CG477_003610	COG2153	protein acetylation
CG477_003620	COG0475	glutathione-regulated potassium exporter activity
CG477_003620	COG0569	domain protein
CG477_003635	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CG477_003640	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CG477_003645	COG0833	amino acid
CG477_003650	COG4990	cell redox homeostasis
CG477_003665	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG477_003670	COG0697	spore germination
CG477_003675	COG0531	amino acid
CG477_003690	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CG477_003695	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CG477_003700	COG1918	ferrous iron import across plasma membrane
CG477_003700	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CG477_003705	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CG477_003710	COG0573	inorganic phosphate transmembrane transporter activity
CG477_003715	COG0581	inorganic phosphate transmembrane transporter activity
CG477_003720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CG477_003760	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG477_003845	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CG477_003870	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CG477_003875	COG1116	anion transmembrane transporter activity
CG477_003880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG477_003885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CG477_003890	COG0352	thiamine-phosphate diphosphorylase activity
CG477_003895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CG477_003900	COG2104	thiamine diphosphate biosynthetic process
CG477_003905	COG2022	thiamine diphosphate biosynthetic process
CG477_003910	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG477_003915	COG0351	phosphomethylpyrimidine kinase
CG477_003945	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CG477_003950	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CG477_003955	COG2205	protein histidine kinase activity
CG477_003965	COG4974	Belongs to the 'phage' integrase family
CG477_003985	COG0735	belongs to the Fur family
CG477_004010	COG1846	Transcriptional regulator
CG477_004020	COG2252	PERMEase
CG477_004025	COG1028	Short-chain dehydrogenase reductase Sdr
CG477_004030	COG1376	ErfK ybiS ycfS ynhG family protein
CG477_004055	COG1316	TRANSCRIPTIONal
CG477_004085	COG0778	Nitroreductase
CG477_004095	COG2719	SpoVR family
CG477_004105	COG1316	TRANSCRIPTIONal
CG477_004110	COG1283	sodium-dependent phosphate transmembrane transporter activity
CG477_004125	COG0577	efflux transmembrane transporter activity
CG477_004130	COG1136	(ABC) transporter
CG477_004140	COG1114	Component of the transport system for branched-chain amino acids
CG477_004145	COG3546	catalase activity
CG477_004200	COG0475	glutathione-regulated potassium exporter activity
CG477_004205	COG1737	Transcriptional regulator
CG477_004215	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CG477_004220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG477_004220	COG1263	PTS System
CG477_004265	COG1522	sequence-specific DNA binding
CG477_004280	COG0531	amino acid
CG477_004290	COG1012	belongs to the aldehyde dehydrogenase family
CG477_004295	COG1132	(ABC) transporter
CG477_004300	COG1132	(ABC) transporter
CG477_004310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG477_004315	COG0765	amino acid transport
CG477_004320	COG1126	abc transporter atp-binding protein
CG477_004335	COG0189	ligase activity
CG477_004340	COG4399	Belongs to the UPF0754 family
CG477_004345	COG3679	Belongs to the UPF0342 family
CG477_004350	COG4585	Histidine kinase
CG477_004355	COG2197	response regulator
CG477_004415	COG2094	Belongs to the DNA glycosylase MPG family
CG477_004420	COG0561	phosphatase activity
CG477_004430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CG477_004435	COG0318	PFAM AMP-dependent synthetase and ligase
CG477_004460	COG2244	polysaccharide biosynthetic process
CG477_004470	COG0860	N-Acetylmuramoyl-L-alanine amidase
CG477_004490	COG1696	Membrane protein involved in D-alanine export
CG477_004505	COG1024	Enoyl-CoA hydratase
CG477_004520	COG1363	Peptidase, m42
CG477_004535	COG2239	Acts as a magnesium transporter
CG477_004540	COG0772	Belongs to the SEDS family
CG477_004545	COG1115	amino acid carrier protein
CG477_004670	COG1476	TRANSCRIPTIONal
CG477_004715	COG1131	(ABC) transporter
CG477_004760	COG0494	nUDIX hydrolase
CG477_004775	COG1061	Type III restriction enzyme res subunit
CG477_004790	COG4638	Rieske (2fe-2S)
CG477_004795	COG1012	belongs to the aldehyde dehydrogenase family
CG477_004800	COG0473	3-isopropylmalate dehydrogenase activity
CG477_004810	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG477_004820	COG1064	alcohol dehydrogenase
CG477_004835	COG3246	L-lysine catabolic process to acetate
CG477_004870	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CG477_004880	COG4641	Protein conserved in bacteria
CG477_004895	COG3711	transcriptional antiterminator
CG477_004900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG477_004900	COG2190	(PTS) system
CG477_004900	COG1263	PTS System
CG477_004905	COG2723	6-phospho-beta-galactosidase activity
CG477_004915	COG2376	Dihydroxyacetone kinase
CG477_004920	COG0393	Putative heavy-metal-binding
CG477_004950	COG0420	3'-5' exonuclease activity
CG477_004955	COG4717	serine-type aminopeptidase activity
CG477_004960	COG3481	metal-dependent phosphohydrolase, HD sub domain
CG477_004975	COG0577	efflux transmembrane transporter activity
CG477_004980	COG1136	(ABC) transporter
CG477_004985	COG5002	protein histidine kinase activity
CG477_004990	COG0745	RESPONSE REGULATOR receiver
CG477_005000	COG1316	TRANSCRIPTIONal
CG477_005015	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CG477_005020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CG477_005025	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CG477_005030	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CG477_005050	COG1846	Transcriptional regulator
CG477_005055	COG4980	gas vesicle protein
CG477_005065	COG0537	adenosine 5'-monophosphoramidase activity
CG477_005070	COG1131	(ABC) transporter
CG477_005075	COG4473	ABC transporter
CG477_005095	COG3402	PFAM membrane-flanked domain
CG477_005105	COG2329	Antibiotic biosynthesis monooxygenase
CG477_005110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG477_005115	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CG477_005155	COG1309	transcriptional regulator
CG477_005165	COG0438	transferase activity, transferring glycosyl groups
CG477_005165	COG1216	Glycosyl transferase, family 2
CG477_005175	COG1609	Transcriptional regulator
CG477_005185	COG1234	tRNA 3'-trailer cleavage
CG477_005190	COG0095	Lipoate-protein ligase
CG477_005200	COG0318	PFAM AMP-dependent synthetase and ligase
CG477_005215	COG2205	protein histidine kinase activity
CG477_005220	COG0745	RESPONSE REGULATOR receiver
CG477_005240	COG0501	Belongs to the peptidase M48B family
CG477_005245	COG0840	transmembrane signaling receptor activity
CG477_005250	COG0697	spore germination
CG477_005265	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CG477_005270	COG2224	Isocitrate lyase
CG477_005275	COG1278	Cold shock
CG477_005280	COG4903	ComK protein
CG477_005285	COG0398	Pfam SNARE associated Golgi protein
CG477_005295	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CG477_005300	COG1074	ATP-dependent DNA helicase activity
CG477_005340	COG0179	Fumarylacetoacetate (FAA) hydrolase
CG477_005360	COG0367	asparagine synthase
CG477_005370	COG0753	catalase activity
CG477_005380	COG1874	Beta-galactosidase
CG477_005380	COG0366	Alpha amylase catalytic
CG477_005385	COG1666	GTP binding
CG477_005390	COG2996	Protein conserved in bacteria
CG477_005405	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG477_005420	COG0561	phosphatase activity
CG477_005445	COG2267	carboxylic ester hydrolase activity
CG477_005460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CG477_005465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CG477_005470	COG5504	Zn-dependent protease
CG477_005480	COG0180	Tryptophanyl-tRNA synthetase
CG477_005495	COG4166	transmembrane transport
CG477_005500	COG0601	transmembrane transport
CG477_005505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CG477_005510	COG0444	Belongs to the ABC transporter superfamily
CG477_005515	COG4608	Belongs to the ABC transporter superfamily
CG477_005520	COG0534	Mate efflux family protein
CG477_005525	COG4166	transmembrane transport
CG477_005545	COG1393	Belongs to the ArsC family
CG477_005550	COG0861	Integral membrane protein TerC family
CG477_005570	COG1164	Oligoendopeptidase f
CG477_005585	COG2346	COG2346, Truncated hemoglobins
CG477_005590	COG4116	CYTH
CG477_005600	COG2357	RelA SpoT domain protein
CG477_005610	COG0564	pseudouridine synthase activity
CG477_005620	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CG477_005625	COG0772	Belongs to the SEDS family
CG477_005670	COG1216	Glycosyl transferase, family 2
CG477_005690	COG0463	Glycosyl transferase, family 2
CG477_005690	COG0457	Tetratricopeptide repeat
CG477_005710	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CG477_005725	COG1091	dTDP-4-dehydrorhamnose reductase activity
CG477_005750	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CG477_005755	COG2382	esterase
CG477_005770	COG5492	domain, Protein
CG477_005775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG477_005790	COG1620	l-lactate permease
CG477_005795	COG5634	Uncharacterized conserved protein (DUF2278)
CG477_005835	COG0508	dehydrogenase complex catalyzes the overall conversion of
CG477_005840	COG0567	Dehydrogenase, E1 component
CG477_005850	COG0583	DNA-binding transcription factor activity
CG477_005855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CG477_005860	COG1012	belongs to the aldehyde dehydrogenase family
CG477_005875	COG0196	riboflavin kinase activity
CG477_005880	COG3162	membrane
CG477_005885	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG477_005890	COG0179	Fumarylacetoacetate (FAA) hydrolase
CG477_005905	COG0457	Tetratricopeptide repeat
CG477_005970	COG0673	inositol 2-dehydrogenase activity
CG477_006000	COG0457	Tetratricopeptide repeat
CG477_006005	COG0582	viral genome integration into host DNA
CG477_006040	COG1686	Belongs to the peptidase S11 family
CG477_006045	COG0681	Belongs to the peptidase S26 family
CG477_006080	COG1012	belongs to the aldehyde dehydrogenase family
CG477_006090	COG1176	ABC-type spermidine putrescine transport system, permease component I
CG477_006095	COG1177	transmembrane transport
CG477_006100	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CG477_006105	COG0671	phosphoesterase, PA-phosphatase related
CG477_006110	COG2409	Drug exporters of the RND superfamily
CG477_006120	COG0564	pseudouridine synthase activity
CG477_006130	COG2340	Cysteine-rich secretory protein family
CG477_006135	COG0247	lactate metabolic process
CG477_006140	COG0277	FAD linked oxidase domain protein
CG477_006145	COG3835	regulator
CG477_006155	COG0745	RESPONSE REGULATOR receiver
CG477_006160	COG5002	protein histidine kinase activity
CG477_006165	COG2186	Transcriptional regulator
CG477_006170	COG0247	lactate metabolic process
CG477_006175	COG1139	Iron-sulfur cluster binding protein
CG477_006180	COG1556	Lactate utilization protein
CG477_006185	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CG477_006190	COG0584	glycerophosphoryl diester phosphodiesterase
CG477_006205	COG2267	carboxylic ester hydrolase activity
CG477_006210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG477_006240	COG2116	formate transmembrane transporter activity
CG477_006245	COG0861	Integral membrane protein TerC family
CG477_006250	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CG477_006260	COG2030	dehydratase
CG477_006280	COG1028	Short-chain dehydrogenase reductase Sdr
CG477_006285	COG3243	poly(R)-hydroxyalkanoic acid synthase
CG477_006290	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CG477_006305	COG1840	ABC-type Fe3 transport system, periplasmic component
CG477_006310	COG3842	ATPase activity
CG477_006320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CG477_006325	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CG477_006330	COG1349	DNA-binding transcription factor activity
CG477_006335	COG0235	Class ii aldolase
CG477_006345	COG2861	carbohydrate metabolic process
CG477_006360	COG3852	Histidine kinase
CG477_006365	COG1846	Transcriptional regulator
CG477_006385	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CG477_006390	COG0720	synthase
CG477_006400	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CG477_006405	COG4873	Protein conserved in bacteria
CG477_006415	COG0456	acetyltransferase
CG477_006435	COG1780	Probably involved in ribonucleotide reductase function
CG477_006450	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CG477_006455	COG1725	Transcriptional regulator
CG477_006460	COG1131	(ABC) transporter
CG477_006470	COG1131	(ABC) transporter
CG477_006475	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CG477_006490	COG1522	sequence-specific DNA binding
CG477_006505	COG1619	proteins homologs of microcin C7 resistance protein MccF
CG477_006510	COG2070	2-Nitropropane dioxygenase
CG477_006515	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CG477_006525	COG1696	Membrane protein involved in D-alanine export
CG477_006530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CG477_006545	COG0716	FMN binding
CG477_006570	COG1368	sulfuric ester hydrolase activity
CG477_006580	COG3173	Aminoglycoside phosphotransferase
CG477_006595	COG5609	conserved protein (DUF2294)
CG477_006600	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CG477_006605	COG3002	Belongs to the UPF0753 family
CG477_006610	COG0288	reversible hydration of carbon dioxide
CG477_006615	COG0534	Mate efflux family protein
CG477_006630	COG1846	Transcriptional regulator
CG477_006640	COG1301	dicarboxylic acid transport
CG477_006645	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CG477_006655	COG3874	Sporulation protein YtfJ
CG477_006680	COG0028	Belongs to the TPP enzyme family
CG477_006685	COG0440	acetolactate synthase activity
CG477_006690	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CG477_006695	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CG477_006705	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CG477_006710	COG0066	3-isopropylmalate dehydratase activity
CG477_006720	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CG477_006730	COG0131	Imidazoleglycerol-phosphate dehydratase
CG477_006735	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CG477_006740	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CG477_006745	COG0107	imidazoleglycerol-phosphate synthase activity
CG477_006750	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CG477_006755	COG0140	phosphoribosyl-ATP diphosphatase activity
CG477_006770	COG1183	phosphatidylcholine synthase activity
CG477_006775	COG1368	sulfuric ester hydrolase activity
CG477_006795	COG0175	sulfate reduction
CG477_006800	COG2046	Belongs to the sulfate adenylyltransferase family
CG477_006805	COG0529	Catalyzes the synthesis of activated sulfate
CG477_006810	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CG477_006830	COG1648	precorrin-2 dehydrogenase activity
CG477_006830	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CG477_006835	COG0733	neurotransmitter:sodium symporter activity
CG477_006850	COG3557	Belongs to the UPF0374 family
CG477_006855	COG1757	Na H antiporter
CG477_006870	COG4758	membrane
CG477_006875	COG4585	Histidine kinase
CG477_006880	COG2197	response regulator
CG477_006885	COG1114	Component of the transport system for branched-chain amino acids
CG477_006890	COG4085	toxin activity
CG477_006890	COG0737	Belongs to the 5'-nucleotidase family
CG477_006890	COG1525	nuclease
CG477_006920	COG3711	transcriptional antiterminator
CG477_006930	COG2723	6-phospho-beta-galactosidase activity
CG477_006945	COG3711	transcriptional antiterminator
CG477_006945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG477_006950	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG477_006950	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG477_006950	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG477_006955	COG1482	cell wall glycoprotein biosynthetic process
CG477_006965	COG2801	Transposase and inactivated derivatives
CG477_006985	COG0730	response to heat
CG477_006990	COG0306	phosphate transporter
CG477_006995	COG1392	Phosphate transport regulator
CG477_007000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG477_007010	COG3852	Histidine kinase
CG477_007015	COG1801	Protein of unknown function DUF72
CG477_007025	COG0582	viral genome integration into host DNA
CG477_007030	COG5002	protein histidine kinase activity
CG477_007035	COG0813	purine-nucleoside phosphorylase activity
CG477_007045	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CG477_007045	COG0392	lysyltransferase activity
CG477_007060	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CG477_007065	COG1686	Belongs to the peptidase S11 family
CG477_007070	COG2715	membrane protein required for spore maturation
CG477_007075	COG0700	Nucleoside recognition
CG477_007080	COG1187	pseudouridine synthase activity
CG477_007090	COG1333	cytochrome c biogenesis protein
CG477_007095	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CG477_007100	COG0745	RESPONSE REGULATOR receiver
CG477_007105	COG5002	protein histidine kinase activity
CG477_007125	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CG477_007130	COG1141	Ferredoxin
CG477_007140	COG0514	ATP-dependent DNA helicase (RecQ)
CG477_007145	COG1266	CAAX protease self-immunity
CG477_007155	COG1408	metallophosphoesterase
CG477_007170	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CG477_007185	COG0492	ferredoxin-NADP+ reductase activity
CG477_007200	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CG477_007210	COG1304	FMN binding
CG477_007235	COG1160	GTP binding
CG477_007240	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CG477_007260	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CG477_007270	COG0302	gtp cyclohydrolase
CG477_007275	COG0142	geranyltranstransferase activity
CG477_007280	COG2226	methyltransferase
CG477_007285	COG0142	geranyltranstransferase activity
CG477_007290	COG0105	UTP biosynthetic process
CG477_007295	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CG477_007300	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CG477_007305	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CG477_007310	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CG477_007315	COG0457	Tetratricopeptide repeat
CG477_007320	COG5582	Belongs to the UPF0302 family
CG477_007335	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CG477_007345	COG4347	Protein of unknown function (DUF1405)
CG477_007360	COG2738	Putative neutral zinc metallopeptidase
CG477_007370	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG477_007375	COG1694	Mazg nucleotide pyrophosphohydrolase
CG477_007380	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CG477_007385	COG1803	Methylglyoxal synthase
CG477_007390	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CG477_007395	COG0438	transferase activity, transferring glycosyl groups
CG477_007400	COG0617	tRNA 3'-terminal CCA addition
CG477_007415	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CG477_007420	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CG477_007425	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CG477_007430	COG1199	ATP-dependent helicase activity
CG477_007430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CG477_007450	COG3935	DnaD domain protein
CG477_007455	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CG477_007465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG477_007465	COG4499	WXG100 protein secretion system (Wss), protein YukC
CG477_007470	COG3331	DNA recombination
CG477_007505	COG4474	Belongs to the UPF0398 family
CG477_007510	COG3599	regulation of cell shape
CG477_007520	COG0116	Belongs to the methyltransferase superfamily
CG477_007530	COG1199	ATP-dependent helicase activity
CG477_007535	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CG477_007540	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CG477_007545	COG2233	PERMEase
CG477_007550	COG2311	Membrane
CG477_007555	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CG477_007565	COG0456	acetyltransferase
CG477_007605	COG3766	membrane
CG477_007610	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CG477_007615	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CG477_007620	COG1733	regulation of RNA biosynthetic process
CG477_007640	COG0328	RNA-DNA hybrid ribonuclease activity
CG477_007670	COG1278	Cold shock
CG477_007680	COG3162	membrane
CG477_007685	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG477_007690	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CG477_007695	COG0475	glutathione-regulated potassium exporter activity
CG477_007700	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CG477_007725	COG2323	membrane
CG477_007730	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CG477_007755	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CG477_007765	COG2201	protein-glutamate methylesterase activity
CG477_007770	COG2198	Histidine kinase
CG477_007770	COG0643	Histidine kinase
CG477_007775	COG1776	CheC inhibitor of MCP methylation
CG477_007775	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG477_007790	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CG477_007810	COG1256	bacterial-type flagellum assembly
CG477_007815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CG477_007820	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CG477_007835	COG1815	bacterial-type flagellum-dependent cell motility
CG477_007840	COG1558	bacterial-type flagellum-dependent cell motility
CG477_007845	COG1677	Flagellar hook-basal body complex protein FliE
CG477_007855	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG477_007865	COG1157	protein secretion by the type III secretion system
CG477_007900	COG0784	Response regulator, receiver
CG477_007900	COG0835	chemotaxis
CG477_007910	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CG477_007915	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CG477_007920	COG0741	lytic transglycosylase activity
CG477_007930	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG477_007935	COG1776	CheC inhibitor of MCP methylation
CG477_007935	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CG477_007945	COG1338	Plays a role in the flagellum-specific transport system
CG477_007950	COG1987	bacterial-type flagellum assembly
CG477_007960	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CG477_007965	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CG477_007970	COG1419	protein localization to endoplasmic reticulum
CG477_007975	COG4786	Flagellar basal body rod
CG477_007980	COG1136	(ABC) transporter
CG477_007980	COG0577	efflux transmembrane transporter activity
CG477_008030	COG2814	Major facilitator Superfamily
CG477_008040	COG1028	Short-chain dehydrogenase reductase Sdr
CG477_008075	COG0367	asparagine synthase
CG477_008095	COG1802	Transcriptional regulator
CG477_008100	COG0697	spore germination
CG477_008110	COG1757	Na H antiporter
CG477_008120	COG0114	fumarate hydratase activity
CG477_008145	COG0534	Mate efflux family protein
CG477_008150	COG3340	Belongs to the peptidase S51 family
CG477_008155	COG2733	membrane
CG477_008165	COG1280	lysine exporter protein (LysE YggA)
CG477_008170	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CG477_008185	COG2502	aspartate--ammonia ligase
CG477_008195	COG0109	protoheme IX farnesyltransferase activity
CG477_008225	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CG477_008235	COG4166	transmembrane transport
CG477_008240	COG2223	nitrite transmembrane transporter activity
CG477_008245	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CG477_008250	COG2244	polysaccharide biosynthetic process
CG477_008255	COG0733	neurotransmitter:sodium symporter activity
CG477_008260	COG5566	PFAM Mor transcription activator
CG477_008275	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CG477_008280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CG477_008290	COG0129	dihydroxy-acid dehydratase activity
CG477_008295	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CG477_008325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG477_008330	COG2814	Major facilitator Superfamily
CG477_008335	COG3384	dioxygenase
CG477_008355	COG0402	S-adenosylhomocysteine deaminase activity
CG477_008360	COG4166	transmembrane transport
CG477_008370	COG1914	H( )-stimulated, divalent metal cation uptake system
CG477_008385	COG0083	homoserine kinase activity
CG477_008395	COG2390	Transcriptional regulator
CG477_008400	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CG477_008425	COG1510	regulation of RNA biosynthetic process
CG477_008435	COG1454	alcohol dehydrogenase
CG477_008450	COG1012	belongs to the aldehyde dehydrogenase family
CG477_008465	COG0628	permease
CG477_008470	COG0039	L-malate dehydrogenase activity
CG477_008475	COG0523	cobalamin synthesis protein
CG477_008500	COG1686	Belongs to the peptidase S11 family
CG477_008515	COG0791	NLP P60 protein
CG477_008515	COG1388	LysM domain
CG477_008520	COG0300	oxidoreductase activity
CG477_008530	COG0460	homoserine dehydrogenase
CG477_008540	COG0083	homoserine kinase activity
CG477_008545	COG1316	TRANSCRIPTIONal
CG477_008550	COG0726	polysaccharide deacetylase
CG477_008560	COG1285	pathogenesis
CG477_008565	COG1247	-acetyltransferase
CG477_008580	COG1752	Esterase of the alpha-beta hydrolase superfamily
CG477_008600	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CG477_008605	COG0577	efflux transmembrane transporter activity
CG477_008610	COG2409	Drug exporters of the RND superfamily
CG477_008615	COG1404	Belongs to the peptidase S8 family
CG477_008630	COG0840	transmembrane signaling receptor activity
CG477_008645	COG3949	Membrane
CG477_008650	COG0783	Belongs to the Dps family
CG477_008670	COG0523	cobalamin synthesis protein
CG477_008680	COG0803	Belongs to the bacterial solute-binding protein 9 family
CG477_008695	COG1902	pentaerythritol trinitrate reductase activity
CG477_008700	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CG477_008710	COG4166	transmembrane transport
CG477_008715	COG0346	lactoylglutathione lyase activity
CG477_008725	COG5337	Spore coat protein CotH
CG477_008730	COG1051	belongs to the nudix hydrolase family
CG477_008735	COG0586	Pfam SNARE associated Golgi protein
CG477_008740	COG2244	polysaccharide biosynthetic process
CG477_008750	COG0701	Predicted permease
CG477_008755	COG3689	TIGRFAM TIGR03943 family protein
CG477_008760	COG1607	acyl-coa hydrolase
CG477_008770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CG477_008780	COG1028	Short-chain dehydrogenase reductase Sdr
CG477_008790	COG2839	Protein conserved in bacteria
CG477_008795	COG1253	flavin adenine dinucleotide binding
CG477_008810	COG1114	Component of the transport system for branched-chain amino acids
CG477_008835	COG0860	N-Acetylmuramoyl-L-alanine amidase
CG477_008845	COG1876	peptidase activity
CG477_008895	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CG477_008900	COG1819	glycosyl
CG477_008905	COG1819	glycosyl
CG477_008910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG477_008960	COG4499	WXG100 protein secretion system (Wss), protein YukC
CG477_009015	COG3874	Sporulation protein YtfJ
CG477_009040	COG2226	methyltransferase
CG477_009065	COG0386	Belongs to the glutathione peroxidase family
CG477_009100	COG0640	Transcriptional regulator
CG477_009105	COG0798	PFAM Bile acid sodium symporter
CG477_009110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CG477_009155	COG1418	mRNA catabolic process
CG477_009160	COG0488	(ABC) transporter
CG477_009170	COG0629	single-stranded DNA binding
CG477_009175	COG1413	lyase activity
CG477_009190	COG2521	methyltransferase
CG477_009190	COG2136	Putative SAM-dependent methyltransferase
CG477_009195	COG0018	arginyl-trna synthetase
CG477_009205	COG0733	neurotransmitter:sodium symporter activity
CG477_009230	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG477_009235	COG0477	Major facilitator Superfamily
CG477_009255	COG2610	gluconate transmembrane transporter activity
CG477_009265	COG0456	acetyltransferase
CG477_009270	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CG477_009280	COG1131	(ABC) transporter
CG477_009285	COG4473	ABC transporter
CG477_009300	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG477_009305	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CG477_009315	COG0768	penicillin binding
CG477_009325	COG0204	Acyl-transferase
CG477_009330	COG1272	protein, Hemolysin III
CG477_009335	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CG477_009340	COG0805	protein transport
CG477_009350	COG1307	EDD domain protein, DegV family
CG477_009360	COG1999	signal sequence binding
CG477_009365	COG0071	Belongs to the small heat shock protein (HSP20) family
CG477_009370	COG0367	asparagine synthase
CG477_009385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CG477_009405	COG0071	Belongs to the small heat shock protein (HSP20) family
CG477_009415	COG1737	Transcriptional regulator
CG477_009420	COG1070	Carbohydrate kinase
CG477_009430	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CG477_009485	COG1151	hydroxylamine reductase activity
CG477_009495	COG1253	flavin adenine dinucleotide binding
CG477_009500	COG5506	Protein of unknown function (DUF1694)
CG477_009520	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CG477_009525	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CG477_009530	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CG477_009535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CG477_009545	COG3829	transcription factor binding
CG477_009555	COG1509	lysine 2,3-aminomutase activity
CG477_009565	COG4479	Belongs to the UPF0346 family
CG477_009590	COG1357	PFAM Pentapeptide repeats (8 copies)
CG477_009590	COG0515	serine threonine protein kinase
CG477_009595	COG0671	phosphoesterase, PA-phosphatase related
CG477_009600	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CG477_009605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG477_009650	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CG477_009660	COG0726	polysaccharide deacetylase
CG477_009665	COG1408	metallophosphoesterase
CG477_009670	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CG477_009675	COG2323	membrane
CG477_009680	COG0671	phosphoesterase, PA-phosphatase related
CG477_009690	COG1280	lysine exporter protein (LysE YggA)
CG477_009695	COG3403	YqcI/YcgG family
CG477_009725	COG4499	WXG100 protein secretion system (Wss), protein YukC
CG477_009725	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG477_009735	COG0372	Belongs to the citrate synthase family
CG477_009740	COG2079	MmgE PrpD family protein
CG477_009745	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CG477_009750	COG1960	acyl-CoA dehydrogenase activity
CG477_009755	COG2084	Dehydrogenase
CG477_009760	COG1012	belongs to the aldehyde dehydrogenase family
CG477_009770	COG1280	lysine exporter protein (LysE YggA)
CG477_009790	COG0420	3'-5' exonuclease activity
CG477_009795	COG0419	ATPase involved in DNA repair
CG477_009800	COG3104	oligopeptide transport
CG477_009830	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CG477_009835	COG1131	(ABC) transporter
CG477_009855	COG1131	(ABC) transporter
CG477_009860	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CG477_009880	COG1942	4-Oxalocrotonate Tautomerase
CG477_009915	COG0457	Tetratricopeptide repeat
CG477_009950	COG1028	Short-chain dehydrogenase reductase Sdr
CG477_009955	COG1169	isochorismate synthase
CG477_009960	COG1021	2,3-dihydroxybenzoate-AMP ligase
CG477_009965	COG3433	isochorismatase activity
CG477_009965	COG1535	isochorismatase
CG477_009970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CG477_009975	COG3251	PFAM MbtH domain protein
CG477_009980	COG2814	Major facilitator Superfamily
CG477_009995	COG0776	regulation of translation
CG477_010010	COG2329	Antibiotic biosynthesis monooxygenase
CG477_010015	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CG477_010050	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CG477_010060	COG0667	Aldo Keto reductase
CG477_010080	COG0010	Belongs to the arginase family
CG477_010090	COG1132	(ABC) transporter
CG477_010095	COG1132	(ABC) transporter
CG477_010100	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CG477_010125	COG1649	PFAM Uncharacterised BCR, COG1649
CG477_010145	COG2971	BadF BadG BcrA BcrD
CG477_010165	COG0588	phosphoglycerate mutase activity
CG477_010195	COG2195	Cleaves the N-terminal amino acid of tripeptides
CG477_010205	COG1960	acyl-CoA dehydrogenase activity
CG477_010210	COG0439	Biotin carboxylase
CG477_010215	COG0511	ligase activity, forming carbon-carbon bonds
CG477_010220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CG477_010225	COG1024	Enoyl-CoA hydratase
CG477_010230	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CG477_010235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CG477_010245	COG1216	Glycosyl transferase, family 2
CG477_010250	COG0640	Transcriptional regulator
CG477_010260	COG1686	Belongs to the peptidase S11 family
CG477_010265	COG5002	protein histidine kinase activity
CG477_010295	COG0789	Transcriptional regulator
CG477_010315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CG477_010325	COG1028	Short-chain dehydrogenase reductase Sdr
CG477_010345	COG0475	glutathione-regulated potassium exporter activity
CG477_010365	COG1309	transcriptional regulator
CG477_010375	COG1028	Short-chain dehydrogenase reductase Sdr
CG477_010380	COG2002	toxin-antitoxin pair type II binding
CG477_010385	COG3773	Cell wall hydrolase
CG477_010385	COG3409	Peptidoglycan-binding domain 1 protein
CG477_010400	COG0693	protein deglycase activity
CG477_010405	COG0201	protein transport
CG477_010425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CG477_010430	COG0322	excinuclease ABC activity
CG477_010445	COG4667	esterase of the alpha-beta hydrolase superfamily
CG477_010465	COG1051	belongs to the nudix hydrolase family
CG477_010515	COG2223	nitrite transmembrane transporter activity
CG477_010565	COG1216	Glycosyl transferase, family 2
CG477_010580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG477_010585	COG1279	arginine transmembrane transporter activity
CG477_010625	COG1794	racemase activity, acting on amino acids and derivatives
CG477_010635	COG2828	Protein conserved in bacteria
CG477_010640	COG5002	protein histidine kinase activity
CG477_010645	COG0561	phosphatase activity
CG477_010665	COG2124	cytochrome p450
CG477_010700	COG0457	Tetratricopeptide repeat
CG477_010710	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CG477_010740	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CG477_010745	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG477_010755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG477_010765	COG2959	enzyme of heme biosynthesis
CG477_010770	COG3773	Cell wall hydrolase
CG477_010770	COG3409	Peptidoglycan-binding domain 1 protein
CG477_010795	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CG477_010800	COG3844	kynureninase activity
CG477_010810	COG1028	Short-chain dehydrogenase reductase Sdr
CG477_010820	COG4176	ABC-type proline glycine betaine transport system permease component
CG477_010825	COG0517	IMP dehydrogenase activity
CG477_010825	COG4175	Glycine betaine
CG477_010855	COG2153	protein acetylation
CG477_010885	COG0514	ATP-dependent DNA helicase (RecQ)
CG477_010905	COG4637	Psort location Cytoplasmic, score
CG477_010910	COG1227	inorganic diphosphatase activity
CG477_010920	COG3397	chitin binding
CG477_010960	COG4166	transmembrane transport
CG477_010970	COG4948	Mandelate Racemase Muconate Lactonizing
CG477_011050	COG1307	EDD domain protein, DegV family
CG477_011100	COG5444	nuclease activity
CG477_011210	COG5444	nuclease activity
CG477_011230	COG2261	transglycosylase associated protein
CG477_011235	COG0675	Transposase, IS605 OrfB family
CG477_011260	COG0436	Aminotransferase
CG477_011275	COG3973	AAA domain
CG477_011280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG477_011305	COG0628	permease
CG477_011320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CG477_011325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG477_011330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CG477_011345	COG2746	aminoglycoside 3-N-acetyltransferase activity
CG477_011360	COG0454	-acetyltransferase
CG477_011360	COG0456	acetyltransferase
CG477_011370	COG0726	polysaccharide deacetylase
CG477_011375	COG3037	sugar-specific permease SgaT UlaA
CG477_011385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG477_011390	COG1368	sulfuric ester hydrolase activity
CG477_011395	COG0488	(ABC) transporter
CG477_011400	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CG477_011400	COG1605	Chorismate mutase
CG477_011420	COG0346	lactoylglutathione lyase activity
CG477_011430	COG3547	Transposase (IS116 IS110 IS902 family)
CG477_011435	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CG477_011475	COG2329	Antibiotic biosynthesis monooxygenase
CG477_011490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG477_011515	COG0494	nUDIX hydrolase
CG477_011530	COG0456	acetyltransferase
CG477_011535	COG0477	Major facilitator Superfamily
CG477_011550	COG0697	spore germination
CG477_011555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG477_011565	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CG477_011580	COG0730	response to heat
CG477_011590	COG0833	amino acid
CG477_011615	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CG477_011630	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CG477_011635	COG1984	allophanate hydrolase subunit 2
CG477_011640	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CG477_011645	COG1414	Transcriptional regulator
CG477_011660	COG1960	acyl-CoA dehydrogenase activity
CG477_011690	COG0346	lactoylglutathione lyase activity
CG477_011700	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CG477_011705	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CG477_011710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CG477_011715	COG0438	transferase activity, transferring glycosyl groups
CG477_011730	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG477_011735	COG0438	transferase activity, transferring glycosyl groups
CG477_011740	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG477_011750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CG477_011770	COG4851	CamS sex pheromone cAM373 precursor
CG477_011895	COG0477	Major facilitator Superfamily
CG477_011910	COG1846	Transcriptional regulator
CG477_011915	COG2814	Major facilitator Superfamily
CG477_011925	COG2031	fatty acid transporter
CG477_011960	COG1122	ATPase activity
CG477_011985	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CG477_012000	COG1131	(ABC) transporter
CG477_012060	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CG477_012065	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG477_012070	COG0579	oxidoreductase
CG477_012075	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CG477_012085	COG1253	flavin adenine dinucleotide binding
CG477_012090	COG0789	Transcriptional regulator
CG477_012095	COG3813	Protein conserved in bacteria
CG477_012175	COG0582	viral genome integration into host DNA
CG477_012215	COG4591	ABC-type transport system involved in lipoprotein release permease component
CG477_012220	COG0577	efflux transmembrane transporter activity
CG477_012220	COG1136	(ABC) transporter
CG477_012285	COG2072	flavoprotein involved in K transport
CG477_012310	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CG477_012315	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CG477_012330	COG1193	negative regulation of DNA recombination
CG477_012335	COG2162	N-hydroxyarylamine O-acetyltransferase activity
CG477_012340	COG1164	Oligoendopeptidase f
CG477_012360	COG0584	glycerophosphoryl diester phosphodiesterase
CG477_012365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG477_012395	COG3397	chitin binding
CG477_012405	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CG477_012410	COG0277	FAD linked oxidase domain protein
CG477_012415	COG1285	pathogenesis
CG477_012420	COG2720	vancomycin resistance protein
CG477_012620	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CG477_012725	COG1484	DNA-dependent DNA replication
CG477_012775	COG0582	viral genome integration into host DNA
CG477_012800	COG1278	Cold shock
CG477_012810	COG1028	Short-chain dehydrogenase reductase Sdr
CG477_012815	COG0165	Argininosuccinate lyase
CG477_012830	COG3409	Peptidoglycan-binding domain 1 protein
CG477_012845	COG4145	pantothenate transmembrane transporter activity
CG477_012855	COG1012	belongs to the aldehyde dehydrogenase family
CG477_012865	COG1657	PFAM Prenyltransferase squalene oxidase
CG477_012870	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
CG477_012875	COG2962	Rard protein
CG477_012910	COG2226	methyltransferase
CG477_012915	COG4166	transmembrane transport
CG477_012920	COG4166	transmembrane transport
CG477_012925	COG1301	dicarboxylic acid transport
CG477_012930	COG0673	inositol 2-dehydrogenase activity
CG477_012935	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CG477_012940	COG0187	DNA topoisomerase II activity
CG477_012950	COG1832	CoA-binding protein
CG477_012955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CG477_012960	COG0745	RESPONSE REGULATOR receiver
CG477_012975	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CG477_012980	COG4841	protein insertion into membrane
CG477_012990	COG0824	Thioesterase
CG477_013020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG477_013025	COG3655	Transcriptional regulator
CG477_013045	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CG477_013055	COG0726	polysaccharide deacetylase
CG477_013085	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CG477_013090	COG0318	PFAM AMP-dependent synthetase and ligase
CG477_013120	COG0457	Tetratricopeptide repeat
CG477_013195	COG2826	transposase and inactivated derivatives, IS30 family
CG477_013210	COG0534	Mate efflux family protein
CG477_013240	COG3023	N-Acetylmuramoyl-L-alanine amidase
CG477_013250	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG477_013260	COG5002	protein histidine kinase activity
CG477_013265	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CG477_013270	COG0010	Belongs to the arginase family
CG477_013275	COG1228	amidohydrolase
CG477_013280	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CG477_013285	COG2986	histidine ammonia-lyase
CG477_013305	COG4846	Membrane protein involved in cytochrome C biogenesis
CG477_013310	COG0785	Cytochrome C biogenesis protein
CG477_013325	COG0583	DNA-binding transcription factor activity
CG477_013330	COG1380	Effector of murein hydrolase LrgA
CG477_013335	COG1346	cytolysis
CG477_013340	COG4187	Peptidase family M20/M25/M40
CG477_013350	COG0833	amino acid
CG477_013360	COG0730	response to heat
CG477_013370	COG3409	Peptidoglycan-binding domain 1 protein
CG477_013370	COG5632	N-Acetylmuramoyl-L-alanine amidase
CG477_013385	COG1132	(ABC) transporter
CG477_013390	COG1132	(ABC) transporter
CG477_013395	COG3763	UPF0154 protein
CG477_013410	COG3639	organic phosphonate transmembrane transporter activity
CG477_013415	COG3639	organic phosphonate transmembrane transporter activity
CG477_013430	COG0737	Belongs to the 5'-nucleotidase family
CG477_013435	COG4224	UPF0291 protein
CG477_013440	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CG477_013445	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CG477_013460	COG1695	Transcriptional regulator
CG477_013495	COG3328	transposase activity
CG477_013500	COG3328	transposase activity
CG477_013505	COG3328	transposase activity
CG477_013520	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CG477_013545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CG477_013565	COG0730	response to heat
CG477_013620	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CG477_013690	COG3723	Recombinational DNA repair protein, rece pathway
CG477_013735	COG0582	viral genome integration into host DNA
CG477_013740	COG0174	glutamine synthetase
CG477_013745	COG0789	Transcriptional regulator
CG477_013750	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CG477_013755	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CG477_013760	COG2860	membrane
CG477_013765	COG0464	growth
CG477_013780	COG1923	regulation of RNA biosynthetic process
CG477_013785	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CG477_013795	COG1388	LysM domain
CG477_013795	COG3584	3D domain protein
CG477_013800	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG477_013800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG477_013800	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CG477_013805	COG1105	Belongs to the carbohydrate kinase PfkB family
CG477_013810	COG1349	DNA-binding transcription factor activity
CG477_013815	COG2322	membrane
CG477_013840	COG2116	formate transmembrane transporter activity
CG477_013850	COG1937	Protein conserved in bacteria
CG477_013855	COG2819	hydrolase of the alpha beta superfamily
CG477_013860	COG1120	ATPase activity
CG477_013865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG477_013870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG477_013875	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG477_013880	COG2706	6-phosphogluconolactonase activity
CG477_013885	COG2826	transposase and inactivated derivatives, IS30 family
CG477_013890	COG2195	Cleaves the N-terminal amino acid of tripeptides
CG477_013900	COG0346	lactoylglutathione lyase activity
CG477_013915	COG1113	amino acid transport
CG477_013940	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CG477_013945	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CG477_013955	COG4550	Control of competence regulator ComK, YlbF/YmcA
CG477_013960	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CG477_013965	COG1013	pyruvate-flavodoxin oxidoreductase activity
CG477_013970	COG0674	pyruvate-flavodoxin oxidoreductase activity
CG477_013970	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CG477_013980	COG2359	stage V sporulation protein S
CG477_013985	COG1692	metallophosphoesterase
CG477_013990	COG1418	mRNA catabolic process
CG477_013995	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CG477_014000	COG1546	Belongs to the CinA family
CG477_014000	COG1058	Belongs to the CinA family
CG477_014005	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CG477_014010	COG1426	Protein conserved in bacteria
CG477_014025	COG0300	oxidoreductase activity
CG477_014030	COG0612	Peptidase, M16
CG477_014035	COG0612	Peptidase, M16
CG477_014060	COG2188	Transcriptional regulator
CG477_014080	COG0740	serine-type endopeptidase activity
CG477_014105	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CG477_014120	COG0527	aspartate kinase activity
CG477_014125	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CG477_014130	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CG477_014135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CG477_014140	COG1873	PFAM PRC-barrel domain
CG477_014145	COG0612	Peptidase, M16
CG477_014150	COG0726	polysaccharide deacetylase
CG477_014155	COG1185	polyribonucleotide nucleotidyltransferase activity
CG477_014165	COG0196	riboflavin kinase activity
CG477_014170	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CG477_014175	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CG477_014180	COG1550	Protein conserved in bacteria
CG477_014185	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CG477_014190	COG1358	cellular component organization or biogenesis
CG477_014195	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CG477_014200	COG0195	Participates in both transcription termination and antitermination
CG477_014205	COG0779	Required for maturation of 30S ribosomal subunits
CG477_014215	COG0442	prolyl-tRNA aminoacylation
CG477_014220	COG0750	zinc metalloprotease
CG477_014230	COG4589	Belongs to the CDS family
CG477_014240	COG0233	cytoplasmic translational termination
CG477_014245	COG0528	UMP kinase activity
CG477_014250	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CG477_014255	COG0052	Belongs to the universal ribosomal protein uS2 family
CG477_014260	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CG477_014265	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CG477_014270	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CG477_014275	COG4974	Belongs to the 'phage' integrase family
CG477_014280	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CG477_014285	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CG477_014290	COG0758	DNA mediated transformation
CG477_014295	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CG477_014300	COG0045	succinate-CoA ligase (ADP-forming) activity
CG477_014305	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CG477_014320	COG0335	large ribosomal subunit rRNA binding
CG477_014330	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CG477_014335	COG1837	Belongs to the UPF0109 family
CG477_014340	COG0228	four-way junction DNA binding
CG477_014345	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CG477_014350	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CG477_014355	COG0552	protein localization to endoplasmic reticulum
CG477_014360	COG1196	nuclear chromosome segregation
CG477_014365	COG0571	ribonuclease III activity
CG477_014375	COG1028	Short-chain dehydrogenase reductase Sdr
CG477_014380	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CG477_014385	COG0416	fatty acid biosynthetic process
CG477_014390	COG2050	protein possibly involved in aromatic compounds catabolism
CG477_014390	COG1349	DNA-binding transcription factor activity
CG477_014395	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CG477_014400	COG1461	Dihydroxyacetone kinase
CG477_014405	COG1302	Protein conserved in bacteria
CG477_014410	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CG477_014420	COG1564	THIamine pyrophosphokinase
CG477_014425	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CG477_014430	COG1162	GTPase activity
CG477_014435	COG2815	serine threonine protein kinase
CG477_014435	COG0515	serine threonine protein kinase
CG477_014440	COG0631	protein serine/threonine phosphatase activity
CG477_014445	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CG477_014450	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CG477_014450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CG477_014455	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CG477_014460	COG0242	peptide deformylase activity
CG477_014465	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CG477_014470	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CG477_014475	COG1758	RNA polymerase activity
CG477_014480	COG0194	GDP metabolic process
CG477_014490	COG1561	YicC-like family, N-terminal region
CG477_014495	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CG477_014520	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CG477_014525	COG0284	orotidine-5'-phosphate decarboxylase activity
CG477_014530	COG0167	dihydroorotate dehydrogenase activity
CG477_014535	COG0543	2 iron, 2 sulfur cluster binding
CG477_014540	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CG477_014550	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CG477_014555	COG0540	Belongs to the ATCase OTCase family
CG477_014565	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CG477_014575	COG0564	pseudouridine synthase activity
CG477_014580	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CG477_014590	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CG477_014595	COG3599	regulation of cell shape
CG477_014600	COG2302	S4 RNA-binding domain
CG477_014605	COG0762	integral membrane protein
CG477_014610	COG1799	cell septum assembly
CG477_014615	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CG477_014625	COG1873	PFAM PRC-barrel domain
CG477_014630	COG1191	sigma factor activity
CG477_014635	COG1191	sigma factor activity
CG477_014645	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CG477_014650	COG0849	cell division
CG477_014655	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CG477_014665	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CG477_014670	COG0772	Belongs to the SEDS family
CG477_014675	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CG477_014680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CG477_014685	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CG477_014690	COG0768	penicillin binding
CG477_014700	COG4839	cell division protein FtsL
CG477_014705	COG0275	rRNA processing
CG477_014710	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CG477_014715	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CG477_014735	COG1399	metal-binding, possibly nucleic acid-binding protein
CG477_014845	COG4626	Terminase
CG477_014845	COG1802	Transcriptional regulator
CG477_014935	COG0756	dUTP diphosphatase activity
CG477_014965	COG3723	Recombinational DNA repair protein, rece pathway
CG477_014975	COG5377	YqaJ viral recombinase family
CG477_015020	COG0582	viral genome integration into host DNA
CG477_015025	COG1323	Belongs to the UPF0348 family
CG477_015030	COG3480	Lon protease (S16) C-terminal proteolytic domain
CG477_015035	COG1752	Esterase of the alpha-beta hydrolase superfamily
CG477_015040	COG3314	Sporulation integral membrane protein YlbJ
CG477_015045	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CG477_015050	COG0742	ribosomal rna small subunit methyltransferase
CG477_015060	COG4471	UPF0298 protein
CG477_015065	COG3679	Belongs to the UPF0342 family
CG477_015070	COG0406	alpha-ribazole phosphatase activity
CG477_015085	COG2340	Cysteine-rich secretory protein family
CG477_015095	COG3336	cytochrome c oxidase
CG477_015120	COG0109	protoheme IX farnesyltransferase activity
CG477_015125	COG1612	heme a metabolic process
CG477_015130	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CG477_015140	COG0772	Belongs to the SEDS family
CG477_015145	COG4838	Belongs to the UPF0358 family
CG477_015150	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CG477_015155	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CG477_015165	COG4896	Protein conserved in bacteria
CG477_015190	COG0483	inositol monophosphate 1-phosphatase activity
CG477_015200	COG4493	Belongs to the UPF0637 family
CG477_015205	COG4476	Belongs to the UPF0223 family
CG477_015210	COG1982	Orn Lys Arg decarboxylase major
CG477_015250	COG0508	dehydrogenase complex catalyzes the overall conversion of
CG477_015260	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CG477_015275	COG0561	phosphatase activity
CG477_015290	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CG477_015295	COG0569	domain protein
CG477_015305	COG1473	amidohydrolase
CG477_015310	COG2171	N-acyltransferase activity
CG477_015315	COG0583	DNA-binding transcription factor activity
CG477_015320	COG0517	IMP dehydrogenase activity
CG477_015330	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
CG477_015350	COG4703	Protein of unknown function (DUF1797)
CG477_015365	COG2200	EAL domain
CG477_015370	COG1028	Short-chain dehydrogenase reductase Sdr
CG477_015375	COG1408	metallophosphoesterase
CG477_015385	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CG477_015425	COG2814	Major facilitator Superfamily
CG477_015430	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CG477_015440	COG3209	COG3209 Rhs family protein
CG477_015450	COG2205	protein histidine kinase activity
CG477_015460	COG0436	Aminotransferase
CG477_015465	COG1609	Transcriptional regulator
CG477_015470	COG3833	ABC-type maltose transport systems, permease component
CG477_015475	COG1175	transmembrane transport
CG477_015480	COG2182	Extracellular solute-binding protein
CG477_015495	COG0366	Alpha amylase catalytic
CG477_015500	COG3842	ATPase activity
CG477_015530	COG0183	Belongs to the thiolase family
CG477_015560	COG1695	Transcriptional regulator
CG477_015565	COG1028	Short-chain dehydrogenase reductase Sdr
CG477_015575	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CG477_015580	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CG477_015585	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CG477_015590	COG0436	Aminotransferase
CG477_015595	COG1850	ribulose-bisphosphate carboxylase activity
CG477_015600	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
CG477_015605	COG0235	Class ii aldolase
CG477_015610	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CG477_015625	COG2084	Dehydrogenase
CG477_015640	COG0778	Nitroreductase
CG477_015665	COG1263	PTS System
CG477_015665	COG2190	(PTS) system
CG477_015665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CG477_015670	COG3711	transcriptional antiterminator
CG477_015685	COG0363	glucosamine-6-phosphate deaminase activity
CG477_015700	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CG477_015705	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CG477_015715	COG1547	Domain of unknown function (DUF309)
CG477_015725	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CG477_015730	COG4086	secreted protein
CG477_015735	COG0561	phosphatase activity
CG477_015740	COG0697	spore germination
CG477_015755	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CG477_015780	COG0733	neurotransmitter:sodium symporter activity
CG477_015790	COG2172	sigma factor antagonist activity
CG477_015800	COG1686	Belongs to the peptidase S11 family
CG477_015810	COG1725	Transcriptional regulator
CG477_015815	COG1131	(ABC) transporter
CG477_015840	COG1846	Transcriptional regulator
CG477_015855	COG0598	Magnesium transport protein CorA
CG477_015885	COG4974	Belongs to the 'phage' integrase family
CG477_015895	COG0735	belongs to the Fur family
CG477_015900	COG1300	Membrane
CG477_015920	COG0667	Aldo Keto reductase
CG477_015925	COG0656	L-ascorbic acid biosynthetic process
CG477_015930	COG0456	acetyltransferase
CG477_015930	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CG477_015940	COG4085	toxin activity
CG477_015940	COG0737	Belongs to the 5'-nucleotidase family
CG477_015940	COG1525	nuclease
CG477_015950	COG0596	Alpha beta hydrolase
CG477_015955	COG2056	Na+-H+ antiporter family
CG477_015960	COG1609	Transcriptional regulator
CG477_015965	COG0456	acetyltransferase
CG477_015970	COG1073	alpha beta
CG477_015985	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CG477_015985	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CG477_015990	COG0307	riboflavin synthase, alpha
CG477_015995	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CG477_015995	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CG477_016010	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CG477_016015	COG4106	trans-aconitate 2-methyltransferase activity
CG477_016020	COG0596	Alpha beta hydrolase
CG477_016025	COG0156	8-amino-7-oxononanoate synthase activity
CG477_016035	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CG477_016050	COG0737	Belongs to the 5'-nucleotidase family
CG477_016075	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CG477_016085	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CG477_016095	COG0300	oxidoreductase activity
CG477_016100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG477_016105	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CG477_016110	COG1760	l-serine dehydratase
CG477_016115	COG1760	l-serine dehydratase
CG477_016125	COG1234	tRNA 3'-trailer cleavage
CG477_016145	COG2195	Cleaves the N-terminal amino acid of tripeptides
CG477_016150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CG477_016165	COG1376	ErfK ybiS ycfS ynhG family protein
CG477_016170	COG4129	membrane
CG477_016175	COG1126	abc transporter atp-binding protein
CG477_016180	COG0765	amino acid transport
CG477_016185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CG477_016200	COG2816	NAD+ diphosphatase activity
CG477_016205	COG0772	Belongs to the SEDS family
CG477_016215	COG0508	dehydrogenase complex catalyzes the overall conversion of
CG477_016220	COG0022	dehydrogenase e1 component
CG477_016225	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CG477_016230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CG477_016235	COG3426	butyrate kinase activity
CG477_016240	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CG477_016245	COG0280	phosphate acetyltransferase
CG477_016255	COG3290	protein histidine kinase activity
CG477_016255	COG3829	transcription factor binding
CG477_016265	COG0584	glycerophosphoryl diester phosphodiesterase
CG477_016270	COG3093	addiction module antidote protein HigA
CG477_016275	COG0745	RESPONSE REGULATOR receiver
CG477_016280	COG0750	zinc metalloprotease
CG477_016285	COG0497	DNA recombination
CG477_016295	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CG477_016300	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CG477_016310	COG1722	exodeoxyribonuclease VII activity
CG477_016315	COG1570	exodeoxyribonuclease VII activity
CG477_016320	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CG477_016325	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CG477_016330	COG1302	Protein conserved in bacteria
CG477_016335	COG0439	Biotin carboxylase
CG477_016340	COG0511	ligase activity, forming carbon-carbon bonds
CG477_016385	COG3854	ATPases associated with a variety of cellular activities
CG477_016405	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CG477_016410	COG0006	proline dipeptidase activity
CG477_016415	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CG477_016425	COG3872	metal-dependent enzyme
CG477_016435	COG1321	iron dependent repressor
CG477_016450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CG477_016460	COG1609	Transcriptional regulator
CG477_016470	COG2076	Multidrug Resistance protein
CG477_016475	COG2076	Multidrug Resistance protein
CG477_016500	COG1131	(ABC) transporter
CG477_016505	COG1725	Transcriptional regulator
CG477_016520	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CG477_016525	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CG477_016530	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CG477_016535	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CG477_016565	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CG477_016590	COG1459	type II secretion system
CG477_016615	COG4824	toxin secretion phage lysis holin
CG477_016700	COG3728	DNA packaging
CG477_016710	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CG477_016775	COG1484	DNA-dependent DNA replication
CG477_016790	COG3723	Recombinational DNA repair protein, rece pathway
CG477_016795	COG5377	YqaJ viral recombinase family
CG477_016820	COG1396	sequence-specific DNA binding
CG477_016835	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CG477_016870	COG1078	dGTPase activity
CG477_016885	COG1410	methionine synthase
CG477_016885	COG0646	methionine synthase
CG477_016890	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CG477_016890	COG0646	methionine synthase
CG477_016895	COG0626	cystathionine gamma-synthase activity
CG477_016900	COG0626	cystathionine gamma-synthase activity
CG477_016920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG477_016930	COG1940	carbohydrate kinase activity
CG477_016935	COG4483	Protein conserved in bacteria
CG477_016940	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CG477_016945	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CG477_016950	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CG477_016955	COG0704	Plays a role in the regulation of phosphate uptake
CG477_016960	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CG477_016965	COG0581	inorganic phosphate transmembrane transporter activity
CG477_016970	COG0573	inorganic phosphate transmembrane transporter activity
CG477_016975	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CG477_016985	COG0477	Major facilitator Superfamily
CG477_016990	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CG477_017010	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CG477_017015	COG0735	belongs to the Fur family
CG477_017020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CG477_017025	COG1121	(ABC) transporter
CG477_017030	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG477_017040	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CG477_017055	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CG477_017060	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CG477_017065	COG2384	SAM-dependent methyltransferase
CG477_017075	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CG477_017080	COG0358	DNA primase activity
CG477_017085	COG1671	Belongs to the UPF0178 family
CG477_017090	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CG477_017095	COG0517	IMP dehydrogenase activity
CG477_017100	COG1381	Involved in DNA repair and RecF pathway recombination
CG477_017110	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CG477_017120	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CG477_017125	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CG477_017130	COG1480	7TM receptor with intracellular HD hydrolase
CG477_017135	COG1702	phosphate starvation-inducible protein PhoH
CG477_017150	COG1610	YqeY-like protein
CG477_017155	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CG477_017160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CG477_017165	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CG477_017170	COG2264	protein methyltransferase activity
CG477_017175	COG0484	heat shock protein binding
CG477_017180	COG0443	Heat shock 70 kDa protein
CG477_017185	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CG477_017190	COG1420	regulation of RNA biosynthetic process
CG477_017195	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CG477_017200	COG1733	regulation of RNA biosynthetic process
CG477_017205	COG0693	protein deglycase activity
CG477_017210	COG0481	GTPase activity
CG477_017225	COG0268	Binds directly to 16S ribosomal RNA
CG477_017230	COG1466	dna polymerase III delta subunit
CG477_017240	COG2333	competence protein COMEC
CG477_017240	COG0658	competence protein
CG477_017245	COG2131	deaminase
CG477_017250	COG1596	polysaccharide export
CG477_017250	COG1555	photosystem II stabilization
CG477_017255	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CG477_017260	COG2226	methyltransferase
CG477_017265	COG0799	negative regulation of ribosome biogenesis
CG477_017270	COG1713	HD superfamily hydrolase involved in NAD metabolism
CG477_017275	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CG477_017280	COG1534	Rna-binding protein
CG477_017285	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CG477_017290	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CG477_017295	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CG477_017305	COG0688	phosphatidylethanolamine metabolic process
CG477_017310	COG1191	sigma factor activity
CG477_017320	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CG477_017325	COG2357	RelA SpoT domain protein
CG477_017330	COG1785	Belongs to the alkaline phosphatase family
CG477_017335	COG0456	acetyltransferase
CG477_017340	COG2267	carboxylic ester hydrolase activity
CG477_017365	COG3186	Phenylalanine-4-hydroxylase
CG477_017370	COG2154	pterin-4-alpha-carbinolamine dehydratase
CG477_017375	COG2514	catechol 2,3-dioxygenase activity
CG477_017380	COG2259	Doxx family
CG477_017395	COG1609	Transcriptional regulator
CG477_017405	COG0626	cystathionine gamma-synthase activity
CG477_017410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CG477_017415	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CG477_017420	COG2226	methyltransferase
CG477_017435	COG0768	penicillin binding
CG477_017445	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CG477_017450	COG0572	uridine kinase
CG477_017470	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CG477_017480	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CG477_017485	COG4472	Bacterial protein of unknown function (DUF965)
CG477_017490	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CG477_017495	COG0628	permease
CG477_017515	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CG477_017525	COG0482	sulfurtransferase activity
CG477_017530	COG1104	cysteine desulfurase activity
CG477_017535	COG1959	2 iron, 2 sulfur cluster binding
CG477_017540	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CG477_017560	COG2207	Transcriptional regulator
CG477_017570	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CG477_017575	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CG477_017580	COG0124	histidyl-tRNA synthetase
CG477_017600	COG1490	D-aminoacyl-tRNA deacylase activity
CG477_017605	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CG477_017610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CG477_017615	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CG477_017615	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CG477_017620	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CG477_017625	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CG477_017625	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CG477_017635	COG2244	polysaccharide biosynthetic process
CG477_017660	COG1862	Preprotein translocase
CG477_017665	COG0343	queuine tRNA-ribosyltransferase activity
CG477_017670	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CG477_017680	COG2255	four-way junction helicase activity
CG477_017685	COG0632	four-way junction helicase activity
CG477_017690	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CG477_017710	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CG477_017715	COG0157	Belongs to the NadC ModD family
CG477_017720	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CG477_017725	COG1104	cysteine desulfurase activity
CG477_017730	COG1827	regulation of RNA biosynthetic process
CG477_017735	COG2258	MOSC domain
CG477_017740	COG0077	Prephenate dehydratase
CG477_017745	COG0577	efflux transmembrane transporter activity
CG477_017750	COG0577	efflux transmembrane transporter activity
CG477_017755	COG1136	(ABC) transporter
CG477_017760	COG5002	protein histidine kinase activity
CG477_017765	COG0745	RESPONSE REGULATOR receiver
CG477_017775	COG3290	protein histidine kinase activity
CG477_017780	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CG477_017785	COG2868	ribosomal protein
CG477_017795	COG1530	ribonuclease E activity
CG477_017800	COG1994	Peptidase M50
CG477_017805	COG0739	heme binding
CG477_017810	COG2894	cell division
CG477_017815	COG0850	regulation of cytokinetic process
CG477_017825	COG1792	Involved in formation and maintenance of cell shape
CG477_017830	COG1077	Cell shape determining protein MreB Mrl
CG477_017850	COG0424	maF-like protein
CG477_017860	COG0285	dihydrofolate synthase activity
CG477_017885	COG1388	LysM domain
CG477_017885	COG1388	LysM domain
CG477_017890	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CG477_017895	COG0113	porphobilinogen synthase activity
CG477_017900	COG1587	Uroporphyrinogen-III synthase
CG477_017905	COG0181	hydroxymethylbilane synthase activity
CG477_017910	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CG477_017915	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CG477_017920	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CG477_017930	COG0470	DNA polymerase III
CG477_017930	COG1067	ATP-dependent peptidase activity
CG477_017935	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CG477_017940	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG477_017965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CG477_017965	COG1028	Short-chain dehydrogenase reductase Sdr
CG477_017965	COG3321	synthase
CG477_017965	COG4221	oxidoreductase activity
CG477_017980	COG1033	growth of symbiont in host cell
CG477_017980	COG2409	Drug exporters of the RND superfamily
CG477_017990	COG1309	transcriptional regulator
CG477_018050	COG0622	Phosphoesterase
CG477_018060	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CG477_018065	COG5401	PFAM Sporulation and spore germination
CG477_018075	COG2197	response regulator
CG477_018085	COG1959	2 iron, 2 sulfur cluster binding
CG477_018090	COG1668	transmembrane transport
CG477_018095	COG4152	abc transporter atp-binding protein
CG477_018100	COG1360	Flagellar Motor Protein
CG477_018105	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CG477_018115	COG1876	peptidase activity
CG477_018125	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CG477_018130	COG1053	succinate dehydrogenase
CG477_018135	COG2009	succinate dehydrogenase
CG477_018140	COG1719	4-vinyl reductase, 4VR
CG477_018155	COG3118	belongs to the thioredoxin family
CG477_018160	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CG477_018165	COG2086	electron transfer activity
CG477_018170	COG1024	Enoyl-CoA hydratase
CG477_018175	COG1309	transcriptional regulator
CG477_018180	COG0318	PFAM AMP-dependent synthetase and ligase
CG477_018190	COG2318	DinB family
CG477_018210	COG1131	(ABC) transporter
CG477_018215	COG2205	protein histidine kinase activity
CG477_018220	COG0745	RESPONSE REGULATOR receiver
CG477_018230	COG4895	conserved protein (DUF2196)
CG477_018235	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CG477_018240	COG1114	Component of the transport system for branched-chain amino acids
CG477_018245	COG1187	pseudouridine synthase activity
CG477_018255	COG1193	negative regulation of DNA recombination
CG477_018260	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CG477_018260	COG1796	DNA polymerase
CG477_018265	COG1286	toxin biosynthetic process
CG477_018270	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CG477_018295	COG0017	Asparaginyl-tRNA synthetase
CG477_018300	COG0072	phenylalanine-tRNA ligase activity
CG477_018300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CG477_018305	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CG477_018310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CG477_018320	COG1418	mRNA catabolic process
CG477_018335	COG2814	Major facilitator Superfamily
CG477_018340	COG1566	PFAM secretion protein HlyD family protein
CG477_018345	COG1309	transcriptional regulator
CG477_018350	COG1363	Peptidase, m42
CG477_018360	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CG477_018365	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CG477_018370	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CG477_018375	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CG477_018385	COG1484	DNA-dependent DNA replication
CG477_018390	COG3611	Membrane attachment protein
CG477_018395	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CG477_018400	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CG477_018410	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CG477_018420	COG1971	Probably functions as a manganese efflux pump
CG477_018430	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CG477_018430	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CG477_018435	COG5002	protein histidine kinase activity
CG477_018440	COG0745	RESPONSE REGULATOR receiver
CG477_018450	COG0039	L-malate dehydrogenase activity
CG477_018455	COG0538	isocitrate dehydrogenase activity
CG477_018460	COG0372	Belongs to the citrate synthase family
CG477_018465	COG2707	UPF0756 membrane protein
CG477_018470	COG0628	permease
CG477_018475	COG3030	protein affecting phage T7 exclusion by the F plasmid
CG477_018485	COG0205	6-phosphofructokinase activity
CG477_018490	COG0825	malonyl-CoA metabolic process
CG477_018495	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CG477_018500	COG1725	Transcriptional regulator
CG477_018505	COG0281	malic enzyme
CG477_018510	COG0587	DNA-directed DNA polymerase activity
CG477_018525	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CG477_018535	COG4109	DRTGG domain
CG477_018540	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CG477_018545	COG0006	proline dipeptidase activity
CG477_018570	COG1028	Short-chain dehydrogenase reductase Sdr
CG477_018575	COG0589	response to stress
CG477_018600	COG0165	Argininosuccinate lyase
CG477_018605	COG0137	argininosuccinate synthase activity
CG477_018615	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG477_018625	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CG477_018630	COG0827	DNA restriction-modification system
CG477_018635	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CG477_018640	COG3874	Sporulation protein YtfJ
CG477_018650	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CG477_018655	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CG477_018660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CG477_018670	COG0301	tRNA thio-modification
CG477_018675	COG1104	cysteine desulfurase activity
CG477_018680	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CG477_018685	COG0583	DNA-binding transcription factor activity
CG477_018690	COG0697	spore germination
CG477_018695	COG1309	transcriptional regulator
CG477_018700	COG1956	GAF domain-containing protein
CG477_018705	COG0626	cystathionine gamma-synthase activity
CG477_018715	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CG477_018740	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CG477_018750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CG477_018755	COG0454	-acetyltransferase
CG477_018760	COG0517	IMP dehydrogenase activity
CG477_018765	COG0123	including yeast histone deacetylase and acetoin utilization protein
CG477_018770	COG1970	mechanosensitive ion channel activity
CG477_018780	COG1609	Transcriptional regulator
CG477_018790	COG1605	Chorismate mutase
CG477_018790	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CG477_018795	COG3118	belongs to the thioredoxin family
CG477_018805	COG2309	aminopeptidase activity
CG477_018820	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CG477_018830	COG1674	ftsk spoiiie
CG477_018840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CG477_018845	COG4848	Belongs to the UPF0354 family
CG477_018850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG477_018855	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CG477_018875	COG1363	Peptidase, m42
CG477_018885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CG477_018890	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CG477_018900	COG0510	thiamine kinase activity
CG477_018905	COG1523	belongs to the glycosyl hydrolase 13 family
CG477_018915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CG477_018920	COG1349	DNA-binding transcription factor activity
CG477_018925	COG1187	pseudouridine synthase activity
CG477_018930	COG2244	polysaccharide biosynthetic process
CG477_018935	COG2081	HI0933 family
CG477_018940	COG2814	Major facilitator Superfamily
CG477_018950	COG3832	glyoxalase III activity
CG477_018970	COG1329	Transcriptional regulator
CG477_018980	COG2223	nitrite transmembrane transporter activity
CG477_018990	COG0314	molybdopterin synthase activity
CG477_018995	COG1763	Mo-molybdopterin cofactor biosynthetic process
CG477_019000	COG0303	'Molybdopterin
CG477_019005	COG0315	cyclic pyranopterin monophosphate synthase activity
CG477_019010	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CG477_019015	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CG477_019020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CG477_019025	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CG477_019030	COG1140	nitrate reductase beta subunit
CG477_019035	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CG477_019040	COG2181	nitrate reductase activity
CG477_019055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CG477_019065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CG477_019100	COG0495	leucyl-tRNA aminoacylation
CG477_019105	COG2814	Major facilitator Superfamily
CG477_019115	COG1136	(ABC) transporter
CG477_019120	COG0346	lactoylglutathione lyase activity
CG477_019135	COG1242	4 iron, 4 sulfur cluster binding
CG477_019140	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CG477_019145	COG1121	(ABC) transporter
CG477_019155	COG1794	racemase activity, acting on amino acids and derivatives
CG477_019165	COG2378	regulation of single-species biofilm formation
CG477_019175	COG2267	carboxylic ester hydrolase activity
CG477_019180	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CG477_019190	COG0746	molybdenum cofactor guanylyltransferase activity
CG477_019215	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CG477_019225	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CG477_019275	COG0800	Aldolase
CG477_019280	COG2610	gluconate transmembrane transporter activity
CG477_019285	COG1312	Catalyzes the dehydration of D-mannonate
CG477_019295	COG1414	Transcriptional regulator
CG477_019300	COG5632	N-Acetylmuramoyl-L-alanine amidase
CG477_019300	COG3409	Peptidoglycan-binding domain 1 protein
CG477_019310	COG1368	sulfuric ester hydrolase activity
CG477_019325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CG477_019330	COG1116	anion transmembrane transporter activity
CG477_019335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CG477_019350	COG0494	nUDIX hydrolase
CG477_019360	COG1854	S-ribosylhomocysteine lyase activity
CG477_019365	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CG477_019370	COG0288	reversible hydration of carbon dioxide
CG477_019375	COG1271	oxidase subunit
CG477_019380	COG1294	oxidase, subunit
CG477_019410	COG1842	Phage shock protein A
CG477_019455	COG1597	lipid kinase activity
CG477_019460	COG1136	(ABC) transporter
CG477_019470	COG0745	RESPONSE REGULATOR receiver
CG477_019475	COG2205	protein histidine kinase activity
CG477_019480	COG0577	efflux transmembrane transporter activity
CG477_019485	COG1136	(ABC) transporter
CG477_019505	COG4948	Mandelate Racemase Muconate Lactonizing
CG477_019510	COG0318	PFAM AMP-dependent synthetase and ligase
CG477_019515	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CG477_019520	COG0596	Alpha beta hydrolase
CG477_019525	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CG477_019530	COG1169	isochorismate synthase
CG477_019535	COG1575	Belongs to the MenA family. Type 1 subfamily
CG477_019540	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CG477_019545	COG1278	Cold shock
CG477_019565	COG0058	SHG alpha-glucan phosphorylase activity
CG477_019570	COG0297	glycogen (starch) synthase activity
CG477_019575	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CG477_019580	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CG477_019585	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CG477_019590	COG0039	L-malate dehydrogenase activity
CG477_019685	COG0544	peptidyl-prolyl cis-trans isomerase activity
CG477_019720	COG1285	pathogenesis
CG477_019725	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CG477_019735	COG0166	Belongs to the GPI family
CG477_019745	COG2155	Conserved Protein
CG477_019750	COG1098	S1 RNA binding domain
CG477_019755	COG0436	Aminotransferase
CG477_019760	COG1522	sequence-specific DNA binding
CG477_019765	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CG477_019770	COG2267	carboxylic ester hydrolase activity
CG477_019780	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CG477_019785	COG2032	superoxide dismutase activity
CG477_019795	COG5018	Exonuclease
CG477_019800	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CG477_019805	COG0423	glycine-tRNA ligase activity
CG477_019825	COG2050	protein possibly involved in aromatic compounds catabolism
CG477_019835	COG1268	BioY protein
CG477_019840	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CG477_019845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CG477_019855	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CG477_019865	COG3584	3D domain protein
CG477_019885	COG1252	NADH dehydrogenase
CG477_019890	COG0492	ferredoxin-NADP+ reductase activity
CG477_019905	COG1683	Conserved Protein
CG477_019940	COG1131	(ABC) transporter
CG477_019965	COG0316	Belongs to the HesB IscA family
CG477_019970	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CG477_019975	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG477_019985	COG1252	NADH dehydrogenase
CG477_019990	COG2824	Alkylphosphonate utilization operon protein PhnA
CG477_020000	COG3655	Transcriptional regulator
CG477_020015	COG4837	Protein of unknown function (DUF1462)
CG477_020020	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CG477_020025	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CG477_020030	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CG477_020035	COG0647	UMP catabolic process
CG477_020045	COG2445	Protein of unknown function DUF86
CG477_020050	COG1494	fructose-1,6-bisphosphatase
CG477_020060	COG4470	Protein conserved in bacteria
CG477_020070	COG0789	Transcriptional regulator
CG477_020075	COG4377	Putative membrane peptidase family (DUF2324)
CG477_020090	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CG477_020095	COG0739	heme binding
CG477_020105	COG3377	Domain of unknown function (DUF1805)
CG477_020110	COG0737	Belongs to the 5'-nucleotidase family
CG477_020130	COG0719	Fe-S assembly protein
CG477_020135	COG0822	iron-sulfur transferase activity
CG477_020140	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CG477_020145	COG0719	Fe-S assembly protein
CG477_020150	COG0396	ATPase activity
CG477_020155	COG1464	Belongs to the NlpA lipoprotein family
CG477_020160	COG2011	ABC-type metal ion transport system permease component
CG477_020175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CG477_020180	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CG477_020190	COG0509	glycine decarboxylation via glycine cleavage system
CG477_020195	COG1393	Belongs to the ArsC family
CG477_020235	COG1960	acyl-CoA dehydrogenase activity
CG477_020240	COG0183	Belongs to the thiolase family
CG477_020245	COG1024	Enoyl-CoA hydratase
CG477_020245	COG1250	3-hydroxyacyl-CoA dehydrogenase
CG477_020255	COG1686	Belongs to the peptidase S11 family
CG477_020280	COG0011	TIGRFAM Protein of
CG477_020285	COG0840	transmembrane signaling receptor activity
CG477_020305	COG0531	amino acid
CG477_020310	COG0706	membrane insertase activity
CG477_020320	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CG477_020330	COG0586	Pfam SNARE associated Golgi protein
CG477_020340	COG1376	ErfK ybiS ycfS ynhG family protein
CG477_020345	COG0745	RESPONSE REGULATOR receiver
CG477_020350	COG5002	protein histidine kinase activity
CG477_020355	COG0840	transmembrane signaling receptor activity
CG477_020360	COG0840	transmembrane signaling receptor activity
CG477_020365	COG2151	metal-sulfur cluster biosynthetic enzyme
CG477_020370	COG3227	Zinc metalloprotease (Elastase)
CG477_020375	COG1741	Belongs to the pirin family
CG477_020390	COG0783	Belongs to the Dps family
CG477_020395	COG1611	Belongs to the LOG family
CG477_020420	COG0803	Belongs to the bacterial solute-binding protein 9 family
CG477_020425	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CG477_020430	COG1121	(ABC) transporter
CG477_020450	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG477_020455	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG477_020460	COG1115	amino acid carrier protein
CG477_020465	COG2910	NAD(P)H-binding
CG477_020480	COG1252	NADH dehydrogenase
CG477_020495	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CG477_020510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CG477_020515	COG4977	sequence-specific DNA binding
CG477_020515	COG1917	Cupin 2, conserved barrel domain protein
CG477_020520	COG3223	Belongs to the PsiE family
CG477_020525	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CG477_020545	COG0697	spore germination
CG477_020560	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CG477_020565	COG0557	exoribonuclease II activity
CG477_020570	COG1647	Serine aminopeptidase, S33
CG477_020575	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CG477_020580	COG1346	cytolysis
CG477_020590	COG0148	phosphopyruvate hydratase activity
CG477_020595	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CG477_020600	COG0149	triose-phosphate isomerase activity
CG477_020605	COG0126	phosphoglycerate kinase activity
CG477_020610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CG477_020625	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CG477_020675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CG477_020690	COG2323	membrane
CG477_020700	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG477_020705	COG1481	regulation of sporulation
CG477_020710	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CG477_020715	COG1660	Displays ATPase and GTPase activities
CG477_020720	COG1051	belongs to the nudix hydrolase family
CG477_020730	COG0492	ferredoxin-NADP+ reductase activity
CG477_020735	COG0457	Tetratricopeptide repeat
CG477_020740	COG0110	maltose O-acetyltransferase activity
CG477_020750	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CG477_020755	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CG477_020760	COG1950	PFAM Membrane protein of
CG477_020770	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CG477_020785	COG0789	Transcriptional regulator
CG477_020805	COG0583	DNA-binding transcription factor activity
CG477_020820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CG477_020825	COG3409	Peptidoglycan-binding domain 1 protein
CG477_020825	COG0793	Belongs to the peptidase S41A family
CG477_020830	COG2177	Part of the ABC transporter FtsEX involved in
CG477_020835	COG2884	Cell division ATP-binding protein ftsE
CG477_020870	COG1278	Cold shock
CG477_020875	COG1040	competence protein
CG477_020880	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CG477_020885	COG1388	LysM domain
CG477_020885	COG0791	NLP P60 protein
CG477_020890	COG1733	regulation of RNA biosynthetic process
CG477_020895	COG1307	EDD domain protein, DegV family
CG477_020900	COG1739	Uncharacterized protein family UPF0029
CG477_020905	COG1316	TRANSCRIPTIONal
CG477_020915	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CG477_020925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CG477_020935	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CG477_020935	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CG477_020950	COG1486	melibiose metabolic process
CG477_020955	COG1447	Phosphotransferase system cellobiose-specific component IIA
CG477_020970	COG1447	Phosphotransferase system cellobiose-specific component IIA
CG477_020975	COG1301	dicarboxylic acid transport
CG477_020980	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CG477_020990	COG1271	oxidase subunit
CG477_020995	COG1294	oxidase, subunit
CG477_021000	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CG477_021005	COG1620	l-lactate permease
CG477_021010	COG2389	metal-binding protein
CG477_021020	COG1368	sulfuric ester hydrolase activity
CG477_021030	COG0791	NLP P60 protein
CG477_021030	COG1388	LysM domain
CG477_021035	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CG477_021045	COG1215	transferase activity, transferring glycosyl groups
CG477_021055	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CG477_021060	COG3584	3D domain protein
CG477_021060	COG1388	LysM domain
CG477_021075	COG4715	Zinc finger, swim domain protein
CG477_021080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CG477_021120	COG0577	efflux transmembrane transporter activity
CG477_021125	COG1136	(ABC) transporter
CG477_021160	COG3850	Histidine kinase
CG477_021160	COG5002	protein histidine kinase activity
CG477_021165	COG0745	RESPONSE REGULATOR receiver
CG477_021175	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CG477_021185	COG1215	transferase activity, transferring glycosyl groups
CG477_021185	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CG477_021190	COG1134	teichoic acid transport
CG477_021195	COG1682	transport, permease protein
CG477_021200	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CG477_021205	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CG477_021205	COG0463	Glycosyl transferase, family 2
CG477_021210	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CG477_021215	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CG477_021230	COG1609	Transcriptional regulator
CG477_021240	COG0739	heme binding
CG477_021255	COG3279	Response regulator of the LytR AlgR family
CG477_021260	COG2385	sporulation resulting in formation of a cellular spore
CG477_021275	COG4836	Membrane
CG477_021280	COG1007	ATP synthesis coupled electron transport
CG477_021285	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG477_021290	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CG477_021295	COG0713	ATP synthesis coupled electron transport
CG477_021300	COG0839	Belongs to the complex I subunit 6 family
CG477_021310	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CG477_021315	COG0649	NAD binding
CG477_021320	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG477_021325	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG477_021330	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CG477_021335	COG5001	Diguanylate cyclase
CG477_021335	COG3300	MHYT domain
CG477_021340	COG5001	Diguanylate cyclase
CG477_021340	COG3300	MHYT domain
CG477_021355	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CG477_021360	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CG477_021370	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CG477_021375	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CG477_021380	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CG477_021385	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CG477_021390	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CG477_021415	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CG477_021420	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CG477_021430	COG0698	ribose 5-phosphate isomerase
CG477_021450	COG2190	(PTS) system
CG477_021455	COG2259	Doxx family
CG477_021460	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CG477_021475	COG0009	L-threonylcarbamoyladenylate synthase
CG477_021490	COG2890	protein-(glutamine-N5) methyltransferase activity
CG477_021495	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CG477_021500	COG1435	thymidine kinase activity
CG477_021510	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CG477_021515	COG1494	fructose-1,6-bisphosphatase
CG477_021535	COG4821	SIS domain
CG477_021540	COG0504	CTP synthase activity
CG477_021555	COG1960	acyl-CoA dehydrogenase activity
CG477_021560	COG1960	acyl-CoA dehydrogenase activity
CG477_021565	COG1250	3-hydroxyacyl-CoA dehydrogenase
CG477_021570	COG0183	Belongs to the thiolase family
CG477_021575	COG2181	nitrate reductase activity
CG477_021575	COG0247	lactate metabolic process
CG477_021580	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CG477_021595	COG2197	response regulator
CG477_021600	COG4585	Histidine kinase
CG477_021605	COG0842	Transport permease protein
CG477_021610	COG1131	(ABC) transporter
CG477_021615	COG0024	Methionine aminopeptidase
CG477_021620	COG2234	aminopeptidase activity
CG477_021635	COG4506	Protein conserved in bacteria
CG477_021640	COG1619	proteins homologs of microcin C7 resistance protein MccF
CG477_021655	COG0010	Belongs to the arginase family
CG477_021660	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CG477_021665	COG2814	Major facilitator Superfamily
CG477_021670	COG0789	Transcriptional regulator
CG477_021675	COG0584	glycerophosphoryl diester phosphodiesterase
CG477_021680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CG477_021690	COG1994	Peptidase M50
CG477_021700	COG1078	dGTPase activity
CG477_021705	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CG477_021710	COG1120	ATPase activity
CG477_021715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG477_021720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CG477_021725	COG4844	belongs to the
CG477_021740	COG0280	phosphate acetyltransferase
CG477_021755	COG3773	Cell wall hydrolase
CG477_021765	COG2363	Small membrane protein
CG477_021775	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CG477_021780	COG2233	PERMEase
CG477_021785	COG0561	phosphatase activity
CG477_021790	COG2814	Major facilitator Superfamily
CG477_021795	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CG477_021800	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CG477_021805	COG1131	(ABC) transporter
CG477_021810	COG2755	lipolytic protein G-D-S-L family
CG477_021815	COG0460	homoserine dehydrogenase
CG477_021820	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CG477_021835	COG0351	phosphomethylpyrimidine kinase
CG477_021845	COG1966	Carbon starvation protein
CG477_021850	COG3279	Response regulator of the LytR AlgR family
CG477_021855	COG0477	Major facilitator Superfamily
CG477_021865	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CG477_021870	COG0438	transferase activity, transferring glycosyl groups
CG477_021885	COG0840	transmembrane signaling receptor activity
CG477_021900	COG1607	acyl-coa hydrolase
CG477_021905	COG1216	Glycosyl transferase, family 2
CG477_021920	COG0463	Glycosyl transferase, family 2
CG477_021935	COG0463	Glycosyl transferase, family 2
CG477_021940	COG0488	(ABC) transporter
CG477_021945	COG1309	transcriptional regulator
CG477_021950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CG477_021955	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CG477_021955	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CG477_021960	COG0628	permease
CG477_021965	COG1346	cytolysis
CG477_021975	COG3279	Response regulator of the LytR AlgR family
CG477_021980	COG3275	phosphorelay sensor kinase activity
CG477_021985	COG2814	Major facilitator Superfamily
CG477_021990	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
CG477_021995	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CG477_022005	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CG477_022010	COG3711	transcriptional antiterminator
CG477_022010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CG477_022065	COG0582	viral genome integration into host DNA
CG477_022080	COG1132	(ABC) transporter
CG477_022090	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CG477_022100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CG477_022105	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CG477_022110	COG4853	Protein conserved in bacteria
CG477_022120	COG5002	protein histidine kinase activity
CG477_022125	COG0745	RESPONSE REGULATOR receiver
CG477_022150	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CG477_022155	COG0305	Participates in initiation and elongation during chromosome replication
CG477_022160	COG0359	binds to the 23S rRNA
CG477_022165	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CG477_022170	COG4241	membrane
CG477_022175	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CG477_022180	COG0629	single-stranded DNA binding
CG477_022185	COG0360	Binds together with S18 to 16S ribosomal RNA
CG477_022190	COG0012	GTP binding
CG477_022195	COG4481	Protein conserved in bacteria
CG477_022200	COG0668	transmembrane transport
CG477_022210	COG1475	DNA binding
CG477_022215	COG1192	Involved in chromosome partitioning
CG477_022220	COG1475	DNA binding
CG477_022225	COG0357	Ribosomal RNA small subunit methyltransferase G
CG477_022230	COG0445	tRNA wobble uridine modification
CG477_022235	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CG477_022240	COG1847	R3H domain protein
CG477_022245	COG0706	membrane insertase activity
CG477_022250	COG0594	ribonuclease P activity
CG477_022270	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CG477_022275	COG3209	COG3209 Rhs family protein
CG477_022290	COG2003	Belongs to the UPF0758 family
CG477_022470	COG1476	TRANSCRIPTIONal
CG477_022475	COG2197	response regulator
CG477_022485	COG1073	alpha beta
CG477_022520	COG0457	Tetratricopeptide repeat
CG477_022650	COG0791	NLP P60 protein
CG477_022650	COG0741	lytic transglycosylase activity
CG477_022800	COG1192	Involved in chromosome partitioning
CG477_022840	COG0457	Tetratricopeptide repeat
CG477_022850	COG4166	transmembrane transport
CG477_022885	COG4974	Belongs to the 'phage' integrase family
CG477_022965	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CG477_022980	COG0583	DNA-binding transcription factor activity
CG477_023000	COG1028	Short-chain dehydrogenase reductase Sdr